Seronegative Lambert-Eaton myasthenic syndrome: study of 110 Japanese patients.
The authors characterized the clinical and immunologic features of 110 patients with Lambert-Eaton myasthenic syndrome (LEMS). Anti-P/Q-type voltage-gated calcium channels (VGCC) antibodies were detected in 85% of the patients (seropositive) but not in the rest (seronegative). Except for the indication that small cell lung carcinoma is less common in seronegative patients, no significant differences were found in the clinical characteristics of patients who had or did not have anti-P/Q-type VGCC antibodies. The results of passive transfer experiments suggest that seronegative LEMS is also an autoantibody-mediated disorder.
Nakao
Y K
YK
First Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Japan.
Motomura
M
M
Fukudome
T
T
Fukuda
T
T
Shiraishi
H
H
Yoshimura
T
T
Tsujihata
M
M
Eguchi
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D020865:Calcium Channels, P-Type / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000494:pharmacology; D007564:Japan; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009460:Neurologic Examination; D009435:Synaptic Transmission / Q000502:physiology
D020865:Calcium Channels, P-Type; D007074:Immunoglobulin G