Genetics (molecular biology) and Meniere's disease.
COCH is not the FMD gene detected in our linkage study; furthermore, COCH and FMD are not allelic. The indications are that FMD is heterogenetic. The linkage analysis points to the possibility of one FMD mutation in one of the neighboring candidate genes on chromosome 14, and, with anticipation, possibly a triple repeat amplification. Recently, the myotonic dystrophy type 2 locus has been shown to contain an expanded tetranucleotide repeat [46], so the search for a similar repeat on 14q is indicated.
Morrison
Andrew W
AW
Royal London Hospital, London, UK. a.morrison@which.net
Johnson
Keith J
KJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D016009:Chi-Square Distribution; D002648:Child; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D004569:Electroencephalography; D005260:Female; D005784:Gene Amplification; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics; D009154:Mutation; D010375:Pedigree; D012306:Risk; D011795:Surveys and Questionnaires; D018911:Trinucleotide Repeats
D006680:HLA Antigens