Nonnatural substrates for polyketide synthases and their associated modifying enzymes.
Polyketides are a large class of structurally diverse, biologically active natural products. Recent experiments add evidence that many of the enzymes involved in the biosynthesis of these natural products are intrinsically tolerant of nonnatural substrates. In addition, an increasing understanding of structure-function relationships in various enzyme-substrate systems is aiding efforts to begin engineering these proteins for even greater synthetic utility.
Pohl
Nicola L
NL
Department of Chemistry and the Plant Sciences Institute, 2756 Gilman Hall, Iowa State University, Ames, IA 50011-3111, USA. npohl@iastate.edu
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism*; D015202:Protein Engineering; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D009097:Multienzyme Complexes