title: Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
abstract: OBJECTIVE
  To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A full-thickness section of canaliculus was obtained during surgical repair.
  
  
  METHODS
  Histopathologic changes in the specimen.
  
  
  RESULTS
  The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen.
  
  
  CONCLUSIONS
  Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
authors.affiliation: Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
authors.forename: Madhu R
authors.initials: MR
authors.lastname: Agarwal
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
authors.forename: Michael A
authors.initials: MA
authors.lastname: Burnstine
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy; D003608:Dacryocystorhinostomy; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007765:Lacrimal Apparatus / Q000187:drug effects* / Q000473:pathology* / Q000601:surgery; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced* / Q000473:pathology; D008679:Metaplasia
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil