title: Ketene dithioacetals in the aza-Diels-Alder reaction with N-arylimines: a versatile approach to tetrahydroquinolines, 2,3-dihydro-4-quinolones, and 4-quinolones.
abstract: [reaction: see text] The first successful use of ketene dithioacetals as dienophiles in the aza-Diels-Alder reaction with N-arylimines is described. Among the ketene dithioacetals tested, 1,4-benzodithiafulvenes are most effective in assembling the tetrahydroquinoline core. Subsequent chemical manipulations provide a concise and divergent approach to the synthesis of 2,3-tetrahydroquinolines, 2,3-dihydro-4-quinolones, and 4-quinolones.
authors.affiliation: Deltagen Research Laboratories, 4570 Executive Drive, Suite 400, San Diego, California, USA.
authors.forename: Dai
authors.initials: D
authors.lastname: Cheng
authors.forename: Jinglan
authors.initials: J
authors.lastname: Zhou
authors.forename: Eddine
authors.initials: E
authors.lastname: Saiah
authors.forename: Graham
authors.initials: G
authors.lastname: Beaton