[Changes of blood vessel active substances in acute pulmonary embolism induced by echinococus granulous cyst in rabbits].
OBJECTIVE
To investigate the role of blood vessel active substances, such as endothelin-1 (ET-1), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-K-PGF(1alpha)) in a rabbit model of acute pulmonary embolism induced by echinococus granulous cyst.


METHODS
Catheters were placed into the femoral artery and the femoral vein. Saline, fresh clear cyst fluid or sand containing cyst fluid in a volume of 2 ml/kg were infused through the femoral vein catheter. Changes of ET-1, TXB(2) and 6-K-PGF(1alpha) were measured; PaO(2), PaCO(2), pH, MAP, heart rate, and respiration rate were recorded; and radionuclide lung perfusion scan and the change of heart and lung pathology were studied.


RESULTS
The changes of the studied parameters were not remarkable in the saline treated animals (P > 0.05). TXB(2) and 6-K-PGF(1alpha) were elevated in the cyst fluid treated animals (P < 0.05). PaO(2), PaCO(2), and MAP declined in the clear cyst fluid group (P < 0.05), but their changes were more significant in animals treated with sand containing cyst fluid. Radionuclide lung perfusion scan showed radioactivity defect or attenuation. Histological examination of the lungs revealed diffuse alveolar damage.


CONCLUSIONS
Sand containing cyst fluid caused a more severe disease in this rabbit model of acute pulmonary embolism, suggesting that it played an important role in the induction of lung damage.
Tuersun
Kelibiena
K
Department of Respiratory Medicine, Xinjiang Medical University, Urumqi 830054, China.
Huang
Yifen
Y
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D004443:Echinococcosis / Q000150:complications*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D011655:Pulmonary Embolism / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011817:Rabbits; D011877:Radionuclide Imaging; D013929:Thromboxane B2 / Q000097:blood*
D019332:Endothelin-1; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha