DNA methylation in cancer and ageing.
Epigenetic gene silencing through DNA methylation is now clearly thought to be one of the important steps in the mechanism underlying tumourigenesis. The methylation of several genes increases with age in normal tissues such as the colon. Methylation related to cancer and ageing may lead to new biomarkers and therapeutic concepts for cancer.
Yuasa
Yasuhito
Y
Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. yuasa.monc@tmd.ac.jp
D000375:Aging / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*