3,3-difluoro-1-iodocyclopropenes: a simple synthesis and their reactions.
The [1 + 2] cycloaddition reaction of 1-iodoalkynes with difluorocarbene, generated from the decomposition of FSO(2)CF(2)COOSiMe(3) in diglyme in the presence of 10 mol % NaF at 120 degrees C, gives 3,3-difluoro-1-iodocyclopropenes in good yields. These new iodides can be trifluoromethylated and functionalized via the Heck reaction. The unusual hydrolytic reactions of the iodides under acidic conditions was also investigated.
Xu
Wei
W
Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, 200032 Shanghai, China.
Chen
Qing-Yun
QY