beta-Homolysine oligomers: a new class of Trojan carriers.
We describe the design, synthesis and cell-membrane translocation properties of a series of beta-peptides with the general sequence fluorescein-Adoa-(beta-homolysine)(n)-NH(2), n=5-8 and Adoa=8-amino-3,6-dioxaoctanoic acid. These beta-peptides are able to cross the cytoplasmic membrane and accumulate in the nucleus of mammalian cells.
García-Echeverría
C
C
Oncology Research, Novartis Pharma Inc., CH-4002 Basel, Switzerland. c.garcía-echeverría@pharma.novartis.com
Ruetz
Stephan
S
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D015195:Drug Design; D019793:Fluorescein / Q000138:chemical synthesis; D016650:Fluorescein-5-isothiocyanate; D019044:Image Cytometry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D019810:Sodium Azide / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D009842:Oligopeptides; D014665:Vasodilator Agents; D019810:Sodium Azide; D016650:Fluorescein-5-isothiocyanate; D019793:Fluorescein