title: [Effects of olprinone hydrochloride on intraocular pressure and ocular blood flow in patients after cardiac surgery under cardiopulmonary bypass].
abstract: BACKGROUND
  We evaluated the effect of olprinone hydrochloride on intraocular pressure (IOP) and ocular blood flow in patients after cardiac surgery under cardiopulmonary bypass (CPB).
  
  
  METHODS
  Nine patients after cardiac surgery under CPB were investigated. We measured IOP of the left eye using tonometer (Tonopen XL, BIO RAD, Osaka), and mean blood flow velocity in the left ophthalmic artery (Vm) and calculated the pulsatility index in the left ophthalmic artery (PI) using 2 MHz Doppler ultrasound system (Multidop P, DWL, Germany). After baseline measurement, the olprinone hydrochloride loading dosage was increased from 0.15 to 0.3 microgram.kg-1.min-1 every 60 minutes. The intraocular pressure and ocular blood flow were measured at each point.
  
  
  RESULTS
  IOP and PI decreased significantly, and Vm increased significantly at the infusion rate of 0.3 microgram.kg-1.min-1 from baseline. There was a significant linear correlations between IOP and Vm.
  
  
  CONCLUSIONS
  We demonstrated that olprinone hydrochloride led to a decrease in IOP and an increase in ocular blood flow in patients after cardiac surgery under CPB.
authors.affiliation: Division of Anesthesia, Miyazaki Prefectural Nobeoka Hospital, Nobeoka 882-0835.
authors.forename: Koji
authors.initials: K
authors.lastname: Goto
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shingu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayano
authors.forename: Shigenori
authors.initials: S
authors.lastname: Yoshitake
authors.forename: Takayuki
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D005123:Eye / Q000098:blood supply*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011728:Pyridones / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D007093:Imidazoles; D011728:Pyridones; C059498:olprinone