title: CSF markers related to pathogenetic mechanisms in Alzheimer's disease.
abstract: Serum amyloid P component (SAP) and complement C1q are found highly co-localized with extracellular fibrillar amyloidbeta (Abeta) deposits in Alzheimer's disease (AD) brain. Conflicting data were reported earlier about the cerebrospinal fluid (CSF) levels of SAP and C1q in AD compared to controls. The objective of the present study was to compare the levels of Abeta(1-42), tau, C1q and SAP in CSF of a well characterized group of AD patients and controls, and to assess the association with dementia severity. Significantly decreased CSF levels of Abeta(1-42) were observed in the AD group (480 +/- 104 ng/L) as compared to controls (1,040 +/- 213 ng/L), whereas tau levels were significantly higher in patients with AD (618 +/- 292 ng/L) than in controls (277 +/- 136 ng/L). Combining the results of Abeta(1-42) and tau measurements resulted in a clear separation between the AD group and the controls. No significant differences in CSF levels of SAP and C1q were observed between the well characterized AD patients and non demented control group. Furthermore, we could not demonstrate a correlation between SAP and C1q CSF levels and the severity of the disease, expressed in Mini-Mental State Examination (MMSE) scores. Therefore, in our opinion these factors can be excluded from the list of potentially interesting biomarkers for AD diagnosis and progression.
authors.affiliation: Department of Clinical Chemistry, Research Institute Neurosciences, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Mulder
authors.forename: S N M
authors.initials: SN
authors.lastname: Schoonenboom
authors.forename: L-O
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Ph
authors.initials: P
authors.lastname: Scheltens
authors.forename: G J
authors.initials: GJ
authors.lastname: van Kamp
authors.forename: R
authors.initials: R
authors.lastname: Veerhuis
authors.forename: C E
authors.initials: CE
authors.lastname: Hack
authors.forename: M
authors.initials: M
authors.lastname: Blomberg
authors.forename: R B H
authors.initials: RB
authors.lastname: Schutgens
authors.forename: P
authors.initials: P
authors.lastname: Eikelenboom
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000209:etiology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers; D015922:Complement C1q / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D000683:Serum Amyloid P-Component / Q000134:cerebrospinal fluid; D012720:Severity of Illness Index; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D000683:Serum Amyloid P-Component; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D015922:Complement C1q