[Effect of therapy with lisinopril on the state of cerebral blood flow in women with hypertension in peri- and postmenopause].
Blood flow in extra and intracranial arteries was assessed by doppler ultrasound in 26 hypertensive women without history of stroke. Studies were performed before treatment, after acute test with lisinopril and in 1 month of therapy with lisinopril. Baseline investigation revealed changes of velocity characteristics of blood flow and resistance indexes indicative of impaired cerebral hemodynamics both at extra- and intracranial level. After treatment with lisinopril signs of improvement of blood flow in extra- and intracranial arteries were found. Most important finding was normalization of ability of extracranial arteries to spasm and dilation presumably associated with restoration of hemodynamic reserve of cerebral vessels.
Zonis
B Ya
BY
Kharakhashian
A V
AV
Volkova
N I
NI
Il'iasov
B B
BB
Sokolov
O Yu
OY
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D002979:Climacteric / Q000502:physiology*; D004453:Echoencephalography; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017706:Lisinopril / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D018608:Ultrasonography, Doppler
D000806:Angiotensin-Converting Enzyme Inhibitors; D017706:Lisinopril