A case of systemic lupus erythematosus that manifested in the course of schizophrenia.
A case of schizophrenia is presented in which SLE was diagnosed after 14-year duration. Antibodies to single and double-stranded DNAs, but not to histone. were detected. This case suggests that similar immunological abnormalities as SLE are associated with the pathogenesis of a group of schizophrenia and that class-switch of anti-dsDNA antibodies are important in the pathogenesis of SLE.
Funauchi
Masunori
M
Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan. funauchi@med.kindai.ac.jp
Yamagata
Toshiaki
T
Nozaki
Yuji
Y
Sugiyama
Masafumi
M
Ikoma
Shin-ya
SY
Kinoshita
Koji
K
Kanamaru
Akihisa
A
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D012559:Schizophrenia / Q000276:immunology / Q000503:physiopathology*
D000974:Antibodies, Antinuclear