Thrombotic thrombocytopenic purpura associated with ticlopidine.
Thrombotic thrombocytopenic purpura is a syndrome characterized by hemolytic anemia, thrombocytopenia, neurological symptoms, fever and renal dysfunction. Although the syndrome is usually associated with various infections, vasculitis and pregnancy, rarely can it be associated with certain neoplasms and drugs such as ticlopidine. A 63-year-old woman, who had undergone coronary angioplasty and had been started on ticlopidine, was admitted to our clinic with a history of vomiting, fatigue, hematuria and deterioration in her cognitive abilities. Thrombotic thrombocytopenic purpura was diagnosed on the basis of neurological changes, an increase in LDH, urea, creatinine, indirect bilirubin levels, anemia and peripheral smear findings. Treatment was initiated with daily plasmapheresis and complete clinical and laboratory recovery developed. The patient was discharged after 14 days.
Türken
Orhan
O
Department of Hematology and Oncology, GATA Haydarpaşa Training Hospital, Istanbul, Turkey.
Oztürk
Ahmet
A
Orhan
Bülent
B
Kandemir
Gökhan
G
Yaylaci
Mustafa
M
D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000175:diagnosis*; D013988:Ticlopidine / Q000009:adverse effects*; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine