Redox signaling through NADPH oxidases: involvement in vascular proliferation and coagulation.
Reactive oxygen species (ROS) have been shown to play important functions as signaling molecules in the vasculature. Several NADPH oxidase isoforms have been identified in endothelial and smooth muscle cells, which are largely responsible for basal and stimulated ROS production in these cells. Moreover, evidence increases that activation of these enzymes contributes to stimulation of signaling cascades modulating essential functions in the vasculature such as endothelial and smooth muscle cell proliferation as well as thrombosis.
Görlach
Agnes
A
Klinik für Kinderkardiologie und angeborene Herzfehler, Deutsches Herzzentrum München des Freistaates Bayern, Klinik an der Technischen Universität München, München, Germany. goerlach@dhm.mhn.de
Kietzmann
Thomas
T
Hess
John
J
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001808:Blood Vessels / Q000166:cytology*; D002455:Cell Division; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010586:Phagocytes / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D017382:Reactive Oxygen Species; D019255:NADPH Oxidases