title: Impaired renal function in progressive multiple sclerosis.
abstract: The authors analyzed renal function in 25 patients with progressive MS. The mean glomerular filtration rate (GFR) was 92 mL/min/1.73 m(2), compared to the predicted GFR of 110 (p < 0.001). Nine of the 25 (36%) patients had abnormally low GFR (<90). The mean serum creatinine for patients with MS was lower than predicted normal values and poorly estimated GFR using standard equations. These data document impaired renal function in patients with progressive MS and have implications for treatment of these patients with potentially nephrotoxic drugs.
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore 21201, USA. pcala001@Umaryland.edu
authors.forename: P A
authors.initials: PA
authors.lastname: Calabresi
authors.forename: H
authors.initials: H
authors.lastname: Austin
authors.forename: M K
authors.initials: MK
authors.lastname: Racke
authors.forename: A
authors.initials: A
authors.lastname: Goodman
authors.forename: P
authors.initials: P
authors.lastname: Choyke
authors.forename: H
authors.initials: H
authors.lastname: Maloni
authors.forename: H F
authors.initials: HF
authors.lastname: McFarland
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000503:physiopathology*; D017595:Renal Plasma Flow / Q000502:physiology; D012189:Retrospective Studies
chemical_list: D003404:Creatinine