title: [Myxedema coma as a rare differential diagnosis of severe consciousness disturbance].
abstract: Myxedema coma is a rare and life-threatening complication of untreated hypothyroidism. Therefore, it must be part of the differential diagnosis in comatose patients. We report one patient who presented with CO(2) narcosis,hypothermia, bradycardia,hyporeflexia, tetraparesis, ascitis, pleural effusions, and heart insufficiency. Examination of the CSF, cranial CT, MRI, and MR angiography were normal. In suspicion of myxedema coma,the patient was treated with high dose L-thyroxine and hydrocortisone for preventing secondary adrenal insufficiency. A fast clinical recovery, decreased T4 (7.2 ng/l) and T3 (0.93 ng/l), and increased TSH (20.19 mU/l) together with the following anamnesis of radio iodine therapy and insufficient thyroxine intake confirmed the diagnosis. In conclusion, treatment of the myxedema coma must be started as soon as the laboratory results are confirmatory, since its course depends on the time of initiation of treatment.
authors.affiliation: Neurologische Klinik, Universität Heidelberg. Rainer_Kollmar@med.uni-heidelberg.de
authors.forename: R
authors.initials: R
authors.lastname: Kollmar
authors.forename: P D
authors.initials: PD
authors.lastname: Schellinger
authors.forename: J
authors.initials: J
authors.lastname: Bardutzky
authors.forename: F
authors.initials: F
authors.lastname: Meisel
authors.forename: M
authors.initials: M
authors.lastname: Schwaninger
mesh_terms: D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000188:drug therapy; D000368:Aged; D003128:Coma / Q000209:etiology*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D008297:Male; D009230:Myxedema / Q000175:diagnosis* / Q000188:drug therapy; D009460:Neurologic Examination; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D013974:Thyroxine; D006854:Hydrocortisone