Control of facial muscle development by MyoR and capsulin.
Members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors control the formation of all skeletal muscles in vertebrates, but little is known of the molecules or mechanisms that confer unique identities to different types of skeletal muscles. MyoR and capsulin are related bHLH transcription factors expressed in specific facial muscle precursors. We show that specific facial muscles are missing in mice lacking both MyoR and capsulin, reflecting the absence of MyoD family gene expression and ablation of the corresponding myogenic lineages. These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles.
Lu
Jian-Rong
JR
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.
Bassel-Duby
Rhonda
R
Hawkins
April
A
Chang
Priscilla
P
Valdez
Renee
R
Wu
Hai
H
Gan
Lin
L
Shelton
John M
JM
Richardson
James A
JA
Olson
Eric N
EN
D000818:Animals; D017209:Apoptosis; D051792:Basic Helix-Loop-Helix Proteins; D001934:Branchial Region / Q000196:embryology / Q000378:metabolism; D019070:Cell Lineage; D002972:Cleft Palate / Q000196:embryology; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins; D005152:Facial Muscles / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018390:Gene Targeting; D006257:Head; D018257:Helix-Loop-Helix Motifs; D006548:Hernia, Diaphragmatic / Q000196:embryology; D006720:Homozygote; D020287:In Situ Nick-End Labeling; D008297:Male; D008410:Masticatory Muscles / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D051379:Mice; D032342:Muscle Cells / Q000166:cytology / Q000502:physiology; D024510:Muscle Development; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000196:embryology; D009154:Mutation; D017570:MyoD Protein / Q000235:genetics / Q000378:metabolism; D051787:Myogenic Regulatory Factor 5; D010641:Phenotype; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D009124:Muscle Proteins; D017570:MyoD Protein; D051787:Myogenic Regulatory Factor 5; D015534:Trans-Activators; D014157:Transcription Factors; C497418:Myf5 protein, mouse; C498449:Ostn protein, mouse; C112923:Tcf21 protein, mouse