Catheter-based transendocardial gene delivery for therapeutic myocardial angiogenesis.
Currently it is unknown which is the most effective and safest delivery strategy for therapeutic myocardial angiogenesis. The enhancing effect of direct intramyocardial injection of angiogenic factors using either open-chest or catheter-based approaches on collateral function has been reported to occur in experimental models and among patients. This report reviews the rationale and current experience of using a catheter-based approach as a promising platform for proangiogenic intramyocardial gene delivery strategy.
Kornowski
Ran
R
Director, Myocardial Revascularization and Angiogenesis, Cardiovascular Research Institute, Washington Hospital Center, 110 Irving St, NW, Suite 4B-1, Washington, DC 20010, USA.
Fuchs
Shmuel
S