[Adhesion molecules in patients with chronic renal failure treated with haemodialysis].
Patients with chronic haemodialysis present with a number of symptoms resulting from immunoincompetence observed in this group. Many of these alterations may be the effect of an interaction of blood with a dialyzer membrane. When blood cells and plasma proteins contact artificial surface of the dialyzer, neutropenia, creation of platelet-leukocyte aggregates and leukocyte degranulation occur. These processes are reflected by changing expressions of adhesion molecules' membrane-bound receptors and levels of their circulating forms. Since the intensity of the above mentioned reactions depends on the type of the dialyzer membrane that is used. Adhesins' receptors may serve as markers of haemodialysis-related bioincompatibility. Meanwhile, further investigation on soluble adhesion molecules should evaluate their usefulness in assessing haemodialysis influence on patients' immunity.
Musiał
Kinga
K
Zwolińska
Danuta
D
D001672:Biocompatible Materials / Q000009:adverse effects; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D015550:Cell Degranulation / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy*; D007958:Leukocyte Count / Q000379:methods; D008567:Membranes, Artificial; D009503:Neutropenia / Q000139:chemically induced; D009504:Neutrophils / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation
D001672:Biocompatible Materials; D015815:Cell Adhesion Molecules; D008567:Membranes, Artificial