title: A three-dimensional computational analysis of fluid-structure interaction in the aortic valve.
abstract: Numerical analysis of the aortic valve has mainly been focused on the closing behaviour during the diastolic phase rather than the kinematic opening and closing behaviour during the systolic phase of the cardiac cycle. Moreover, the fluid-structure interaction in the aortic valve system is most frequently ignored in numerical modelling. The effect of this interaction on the valve's behaviour during systolic functioning is investigated. The large differences in material properties of fluid and structure and the finite motion of the leaflets complicate blood-valve interaction modelling. This has impeded numerical analyses of valves operating under physiological conditions. A numerical method, known as the Lagrange multiplier based fictitious domain method, is used to describe the large leaflet motion within the computational fluid domain. This method is applied to a three-dimensional finite element model of a stented aortic valve. The model provides both the mechanical behaviour of the valve and the blood flow through it. Results show that during systole the leaflets of the stented valve appear to be moving with the fluid in an essentially kinematical process governed by the fluid motion.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Building W-hoog-4.117, PO Box 513, 5600 MB Eindhoven, The Netherlands. j.d.hart@tue.nl
authors.forename: J
authors.initials: J
authors.lastname: De Hart
authors.forename: G W M
authors.initials: GW
authors.lastname: Peters
authors.forename: P J G
authors.initials: PJ
authors.lastname: Schreurs
authors.forename: F P T
authors.initials: FP
authors.lastname: Baaijens
mesh_terms: D001021:Aortic Valve / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001809:Blood Viscosity; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D017276:Friction; D018056:Hemorheology / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D013599:Systole / Q000502:physiology