"Emerging Alzheimer's disease therapies: focusing on the future".
The Center for Neurodegenerative Disease Research (CNDR) organized a 1 day symposium entitled "Emerging Alzheimer's disease Therapies: Focusing On The Future" on November 7th, 2001 at the University of Pennsylvania in Philadelphia, PA. The agenda (Fig. 1) focused on novel therapies for Alzheimer's disease (AD) designed to prevent/eliminate Abeta deposits in the brains of AD patients. While fibrillar Abeta deposits known as senile plaques (SPs) and intraneuronal tau fibrils known as neurofibrillary tangles (NFTs) are diagnostic of AD, >50% of patients with familial or sporadic AD as well as elderly Down's syndrome patients with AD harbor a third type of brain amyloid known as Lewy bodies formed by intraneuronal alpha-synuclein fibrils. Thus, AD is a "triple brain amyloidosis" since three different proteins (tau, alpha-synuclein) or peptide fragments (Abeta) of a larger Abeta precursor protein (APP) fibrillize and aggregate into pathological deposits of amyloid within (NFTs, LBs) and outside (SPs) neurons in AD brains. The symposium is summarized here followed by reviews from symposium speakers who describe potential anti-Abeta therapies some of which are in clinical trials.
Trojanowski
John Q
JQ
Department of Pathology and Laboratory Medicine, The Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA. trojanow@mail.med.upenn.edu
D000368:Aged; D000544:Alzheimer Disease / Q000628:therapy*; D000682:Amyloid / Q000187:drug effects / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D000686:Amyloidosis / Q000628:therapy*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000187:drug effects; D004967:Estrogens / Q000097:blood / Q000494:pharmacology; D005260:Female; D005544:Forecasting; D005853:Geriatrics / Q000639:trends; D020249:Hormone Replacement Therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008024:Ligands; D008297:Male; D051379:Mice; D013739:Testosterone / Q000097:blood / Q000494:pharmacology
D000682:Amyloid; D004967:Estrogens; D008024:Ligands; D013739:Testosterone; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse