[Angiotensin-converting enzyme gene polymorphism in patients with primary disturbances of cardiac conduction].
Increased frequencies of angiotensin-converting enzyme (ACE) D-allele and ID-genotype among patients with idiopathic atrioventricular blocks and I allele and II genotype among patients with idiopathic intraventricular blocks allow to consider these genotypes risk factors of corresponding disturbances of cardiac conduction. Decreased frequency of ACE I allele and II genotype among patients with idiopathic atrioventricular blocks is indicative of a possible protective role of II genotype against development of this type of cardiac conduction defect. Low frequency of D allele and genotype D prevents derangements of conduction in His-Purkinje system.
Nikulina
S Iu
SIu
Shul'man
V A
VA
Vorotnikova
Iu V
IuV
Puzyrev
V P
VP
Kosiankova
T V
TV
D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D015870:Gene Expression; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics* / Q000378:metabolism*
D012083:Renin