title: Identification of differentially expressed genes in human salivary gland tumors by DNA microarrays.
abstract: Differentially expressed genes among different benign and malignant salivary gland tumors were identified by use of cDNA microarrays containing 19,000 human expressed sequence tags. Tumors were classified by using a subset of 486 genes. Benign Warthin's tumor and pleomorphic adenoma showed very distinctive gene expression patterns. One hundred and thirty-three genes differentiated the single malignant clear cell carcinoma from non-tumor salivary glands (P < 0.01), whereas only 16 genes separated it from the highly related benign pleomorphic adenoma (P < 0.01). Fifty-seven cDNAs were associated with mucoepidermoid carcinoma (P < 0.01). The identified genes might help to disclose the molecular mechanisms and processes underlying malignant salivary gland tumors.
authors.affiliation: Laboratorio di Genomica Funzionale, Sezione di Istologia ed Embriologia, Dipartimento di Morfologia ed Embriologia, Università degli Studi di Ferrara, 44100 Ferrara, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Francioso
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
authors.forename: Lara
authors.initials: L
authors.lastname: Tosi
authors.forename: Luca
authors.initials: L
authors.lastname: Scapoli
authors.forename: Furio
authors.initials: F
authors.lastname: Pezzetti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Passerella
authors.forename: Rita
authors.initials: R
authors.lastname: Evangelisti
authors.forename: Antonio
authors.initials: A
authors.lastname: Pastore
authors.forename: Stefano
authors.initials: S
authors.lastname: Pelucchi
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fioroni
authors.forename: Paolo
authors.initials: P
authors.lastname: Carinci
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia
mesh_terms: D018076:DNA, Complementary / Q000378:metabolism; D020224:Expressed Sequence Tags; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D012313:RNA