Sequence of the HLA-B*1573 allele.
We report here the sequence of an HLA B*15 allele, B*1573. Initially, a cord blood unit from the Umbilical Cord Bank of Barcelona was typed by sequence-specific oligonucleotide hybridization and revealed an unusual hybridization pattern. After the cloning, the sequence-based typing assigned two different alleles: B*07021, and a second allele identical to B*1558 in exons 2 and 3, except for a single nucleotide substitution in exon 3, which changed codon 140 from Phe to Leu (TTX-->TTA).
Morante
M P
MP
Department Immunology, Hospital Sant Pau, Barcelona, Spain.
Vidal
S
S
Mosquera
A M
AM
Querol
S
S
García
J
J
Rodríguez-Sánchez
J L
JL
D000483:Alleles; D001483:Base Sequence; D005091:Exons; D005312:Fetal Blood / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D059910:HLA-B15 Antigen; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen