title: [Soluble vascular adhesion-1 molecule in Sneddon syndrome: clinical and prognostic value].
abstract: Clinical significance of a soluble vascular adhesion-1 molecule (pVCAM-1) in Sneddon's syndrome (SS) was studied in 48 SS patients by examination of serum pVCAM-1 level using enzyme immunoassay (R&D, USA). High serum concentration of pVCAM-1 registered in 62.6% of SS patients was associated with extracerebral thromboses, not with severity of cerebral vessel damage. Lethal outcomes for 2 years of follow-up occurred more frequently in patients with a high basal level of pVCAM-1 than in patients with normal level. Thus, development of the pathological process in SS is associated with elevated concentration of serum pVCAM-1 and may serve an additional laboratory indicator of developing extrabrain thrombotic disorders and marker of unfavourable prognosis.
authors.forename: L A
authors.initials: LA
authors.lastname: Kalashnikova
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Samsonov
authors.forename: L A
authors.initials: LA
authors.lastname: Dobrynina
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: M K
authors.initials: MK
authors.lastname: Amirov
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018860:Sneddon Syndrome / Q000097:blood* / Q000150:complications / Q000401:mortality; D018709:Statistics, Nonparametric; D013927:Thrombosis / Q000097:blood / Q000209:etiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1