title: Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature.
abstract: Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.
authors.affiliation: Institute of Virology, Charité School of Medicine, Humboldt University, D-10098 Berlin, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Klempa
authors.forename: Heiko A
authors.initials: HA
authors.lastname: Schmidt
authors.forename: Rainer
authors.initials: R
authors.lastname: Ulrich
authors.forename: Stefan
authors.initials: S
authors.lastname: Kaluz
authors.forename: Milan
authors.initials: M
authors.lastname: Labuda
authors.forename: Helga
authors.initials: H
authors.lastname: Meisel
authors.forename: Brian
authors.initials: B
authors.lastname: Hjelle
authors.forename: Detlev H
authors.initials: DH
authors.lastname: Krüger
mesh_terms: D000818:Animals; D001483:Base Sequence; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae / Q000821:virology*; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics; D011995:Recombination, Genetic