title: PACAP activated adenylate cyclase in human sweat glands. An ultracytochemical study.
abstract: The ultracytochemical localization of adenylate cyclase (AC) was studied after stimulation with pituitary adenylate cyclase activating peptide (PACAP) in human sweat glands. PACAP stimulated AC in both eccrine and apocrine glands. In the secretory cells, enzymatic activity was associated with membranes involved in the secretory mechanism. In both glands, the cells of the excretory duct and myoepithelial cells presented AC activity. These localizations of enzymatic activity suggest a role for PACAP in regulating glandular secretion.
authors.affiliation: Sezione di Anatomia, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita di Perugia, C.P. 81, Succ. 3,06122 Perugia, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Rambotti
authors.forename: S
authors.initials: S
authors.lastname: Simonetti
authors.forename: A
authors.initials: A
authors.lastname: Spreca
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000328:Adult; D001050:Apocrine Glands / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D004439:Eccrine Glands / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009479:Neuropeptides / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D013545:Sweat Glands / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure
chemical_list: C495401:ADCYAP1 protein, human; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D000262:Adenylyl Cyclases