Steroid receptors in various glial cell lines expression and functional studies.
In glial cell lines from the central (CG4, C6) and peripheral (MSC80, CR3a1, and CR1b4) nervous systems, glucocorticoid receptor (GR) messenger RNA was clearly detected and was consistent with significant GR binding and transcriptional activity. Mineralocorticosteroid receptor mRNA was less abundant, with no corresponding binding and lack of transcriptional activity. Other steroid receptors were not significantly detected.
Cadepond
Francoise
F
INSERM U488, 80 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre, France. cadepond@kb.inserm.fr
Massaad
Charbel
C
Trousson
Amalia
A
Grenier
Julien
J
Groyer
Ghislaine
G
Baulieu
Etienne
E
Schumacher
Michael
M
D000818:Animals; D002460:Cell Line; D009457:Neuroglia; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology*; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid