The dual role of IL-10.
Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this "antigen-loading" phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of "loaded" APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.
Mocellin
Simone
S
Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, I-35128 Padua, Italy.
Panelli
Monica C
MC
Wang
Ena
E
Nagorsen
Dirk
D
Marincola
Francesco M
FM
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology
D016753:Interleukin-10