Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors.
Brohm
Dirk
D
Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Metzger
Susanne
S
Bhargava
Ajay
A
Müller
Oliver
O
Lieb
Folker
F
Waldmann
Herbert
H
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000201:enzymology; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
D001688:Biological Products; D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone