title: S100A8 and S100A9 calcium-binding proteins: localization within normal and cyclosporin A-induced overgrowth gingiva.
abstract: S100A8 and S100A9, also called myeloid related protein (MRP) 8 and 14, are calcium-binding proteins highly expressed in neutrophils, in which they play a key role in the inflammatory progression. In this study, we looked at the expression of S100A8/A9 within gingiva from normal and Cyclosporin A (CsA)-induced overgrowth gingiva. In gingiva from the CsA group, several positive S100A8/A9 cells were seen within the connective tissue, whereas in normal gingiva very few positive S100A8/A9 cells were detected. These cells correspond either to activated macrophages or to neutrophils, reflecting the well-known gingival inflammatory status associated with the CsA-treated group. In addition, in both the normal and drug-treated group, the gingival epithelia appeared S100A8/A9 immunopositive. More specifically, S100A8/A9 appeared in the majority within the spino-cellular layer and located extracellularly within the desmosomes. In addition, S100A8/A9 also appeared sporadically intracellularly, located within the cytoplasm and the nuclei, reflecting S100A8/A9 translocations.
authors.affiliation: Laboratory of Histopathology, Free University of Brussels, Head and Neck Center, Department of Stomatology and Maxillo-Facial Surgery, Erasme Hospital, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Echelard
authors.forename: D
authors.initials: D
authors.lastname: Hoyaux
authors.forename: M
authors.initials: M
authors.lastname: Hermans
authors.forename: P
authors.initials: P
authors.lastname: Daelemans
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.forename: P
authors.initials: P
authors.lastname: Philippart
authors.forename: R
authors.initials: R
authors.lastname: Pochet
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D040501:Calgranulin A / Q000378:metabolism*; D040502:Calgranulin B / Q000378:metabolism*; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005881:Gingiva / Q000378:metabolism; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014018:Tissue Distribution
chemical_list: D002135:Calcium-Binding Proteins; D040501:Calgranulin A; D040502:Calgranulin B; D007166:Immunosuppressive Agents; D016572:Cyclosporine