title: Gender impact on first trimester markers in Down syndrome screening.
abstract: The influence of fetal gender on the level in the first trimester of the serological markers alpha-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (betahCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free betahCG, being 16% higher for female than for male fetuses.
authors.affiliation: Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark. sol@ssi.dk
authors.forename: Severin Olesen
authors.initials: SO
authors.lastname: Larsen
authors.forename: Karen R
authors.initials: KR
authors.lastname: Wøjdemann
authors.forename: Anne-Cathrine
authors.initials: AC
authors.lastname: Shalmi
authors.forename: Karin
authors.initials: K
authors.lastname: Sundberg
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.forename: Ann
authors.initials: A
authors.lastname: Tabor
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003718:Denmark / Q000453:epidemiology; D004314:Down Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D009333:Neck / Q000000981:diagnostic imaging / Q000196:embryology; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D012727:Sex Characteristics; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D011266:Pregnancy-Associated Plasma Protein-A