title: Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
abstract: Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB(1) receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
authors.affiliation: DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy. appendin@pharm.unito.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Alessia
authors.initials: A
authors.lastname: Ligresti
authors.forename: Alberto
authors.initials: A
authors.lastname: Minassi
authors.forename: Nives
authors.initials: N
authors.lastname: Daddario
authors.forename: Tiziana
authors.initials: T
authors.lastname: Bisogno
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure; D063385:Cannabinoid Receptor Modulators; D002462:Cell Membrane / Q000737:chemistry; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D005989:Glycerides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011869:Radioligand Assay; D051381:Rats; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated; D005989:Glycerides; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; C424442:noladin ether