Hepatic regeneration from hematopoietic stem cells.
In recent years, numerous investigators have reported novel cellular fates of multipotent stem or progenitor cells. In this review, we discuss the unexpected observations that hematopoietic stem cells can contribute to the hepatocyte lineage in humans and in rodent models of liver disease and regeneration. A key unresolved issue regarding hepatic regeneration from hematopoietic stem cells is whether the mechanism occurs through transdetermination, cell fusion, or other processes. A better understanding of the various stem or progenitor cells of the hepatic lineage may facilitate cellular transplantation approaches for the correction of hepatic function in patients with end-stage liver disease.
Austin
Timothy W
TW
StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304, USA.
Lagasse
Eric
E
D000818:Animals; D002454:Cell Differentiation; D002459:Cell Fusion; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology* / Q000637:transplantation; D006801:Humans; D008107:Liver Diseases / Q000628:therapy; D008115:Liver Regeneration; D051379:Mice; D051381:Rats