A novel chiral ferrocenyl phosphine ligand from sugar: applications in Rh-catalyzed asymmetric hydrogenation reactions.
[structure: see text] A new chiral ferrocenyl diphosphine ligand 3 was synthesized from readily available D-mannitol. Rh-complex with this ligand showed high enantioselectivity and reactivity in the asymmetric hydrogenation of dehydroamino acid derivatives and itaconic acid derivatives. Up to over 99% ee and 10 000 TON were achieved with this catalytic system.
Liu
Duan
D
Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
Li
Wenge
W
Zhang
Xumu
X
D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D008353:Mannitol / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D008024:Ligands; D010720:Phosphines; D008353:Mannitol; D012238:Rhodium