Marked thrombocytosis following relapse of acute myeloblastic leukemia associated with development of translocation (2;14) (p13;q32).
Thrombocytosis is a rare finding in acute myeloblastic leukemia (AML). Here, we describe a patient with AML who relapsed with marked thrombocytosis. The patient was initially diagnosed as having AML (M4) with a low platelet count. The patient was started on combination chemotherapy including high-dose etoposide and achieved complete remission. However, the patient relapsed six months later with an extremely high platelet count (72.5 x 10(4)/microl). Cytogenetic analysis at relapse revealed the development of t(2;14)(p13;q32). Despite the repeated combination chemotherapy, the patient died with progressive disease. This case suggests that the additional chromosomal aberration t(2;14)(p13;q32) may be related to abnormal thrombocytosis in AML.
Tasaka
Taizo
T
First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan.
Nagai
Masami
M
Matsuhashi
Yoshiko
Y
Uehara
Eisuke
E
Kakazu
Naoki
N
Abe
Tatsuo
T
Tamura
Takahiro
T
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002889:Chromosomes, Human, Pair 2; D020732:Cytogenetic Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D010976:Platelet Count; D012008:Recurrence; D013922:Thrombocytosis / Q000209:etiology / Q000235:genetics*; D014178:Translocation, Genetic