Biosensors for DNA sequence detection.
DNA biosensors are being developed as alternatives to conventional DNA microarrays. These devices couple signal transduction directly to sequence recognition. Some of the most sensitive and functional technologies use fibre optics or electrochemical sensors in combination with DNA hybridization. In a shift from sequence recognition by hybridization, two emerging single-molecule techniques read sequence composition using zero-mode waveguides or electrical impedance in nanoscale pores.
Vercoutere
Wenonah
W
National Space Grant Foundation, Bone/Signaling Laboratory, NASA Ames Research Center, Mail-Stop 236-7, Moffett Field, CA 94035, USA. wvercoutere@mail.arc.nasa.gov
Akeson
Mark
M
D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D005336:Fiber Optic Technology; D008832:Microchemistry / Q000379:methods; D008958:Models, Molecular; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods
D004247:DNA