[Linkage analysis of susceptibility genes for familial schizophrenia on chromosome 1 in Chinese population].
OBJECTIVE
To explore the molecular genetic relationship between chromosome 1 and susceptibility genes for familial schizophrenia in Chinese population.


METHODS
A genome scanning was conducted in 32 multiplex pedigrees from Chinese population by using 29 microsatellite markers on chromosome 1.


RESULTS
Multipoint parametric analysis detected a maximum heterogenicity Lod of 1.70 at 262.52 cM under a recessive model; multipoint non-parametric analysis detected a maximum non-parameter linkage (NPL) of 1.71 (P=0.046) at 262.52 cM, then 1.37 (P=0.086) at 149.70 cM, corresponding to marker D1S206 and D1S425 respectively.


CONCLUSIONS
These results give further supports to the presence of susceptibility genes on chromosome 1q for familial schizophrenia.
Cai
Guiqing
G
Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou, Guangdong, 510080 P. R. China. caiguiqing@163.com
Wu
Xinyao
X
Li
Tao
T
Collier
David A
DA
Liu
Xiehe
X
Feng
Bingjian
B
Deng
Hong
H
Tong
Dayue
D
Li
Jianjin
J
Ou
Jinghua
J
D000328:Adult; D002681:China; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D008957:Models, Genetic; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*