Effect of different strains of yeast on stereocontrolled reduction of 5-acetylisoxazolines.
The stereocontrolled reduction of 3-aryl-5-acetylisoxazolines (1) to the corresponding alcohols (2 and 3) in the presence of four different yeast strains, recognized as Baker's yeast (commercial), Candida krusei (ATCC 14243), Pichia farinosa (NRRL Y110) and Sacchromyces sp. (soil isolate) have been attempted. The C. krusei was found to be diastereoselective for the (R)-1 while the Sacchromyces sp. led to complete reduction to yield the RS- and SS-alcohol in 1:1 ratio at 10 g/L scale.
Tripathi
M K
MK
Fermentation Technology Division, Central Drug Research Institute, P.O. Box-173, Lucknow 226 001, India.
Jinwal
U K
UK
Roy
U
U
Patra
A
A
Roy
P K
PK
Batra
S
S
Bhaduri
A P
AP
D001711:Biotransformation; D010080:Oxazoles / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D013045:Species Specificity; D013237:Stereoisomerism; D015003:Yeasts / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D010080:Oxazoles