title: Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines.
abstract: Mice selectively bred for high (FAST) or low (SLOW) locomotor stimulant response to ethanol have been found to differ in response to drugs with gamma-aminobutyric acid (GABA)-ergic actions. Reverse selection produced lines that are similar in sensitivity to ethanol stimulation (r-FAST and r-SLOW) and provided a unique model for testing hypotheses about shared genetic influence on sensitivity to ethanol and GABAergic drugs. FAST mice were more stimulated than SLOW mice by all drugs tested: ethanol, methanol, n-propanol, t-butanol, pentobarbital, diazepam, and allopregnanolone. In contrast, r-FAST and r-SLOW mice differed in sensitivity to only a few isolated drug doses. Locomotor responses of each reverse-selected line were significantly different from the responses of their respective forward-selected line for all drugs. Results support an effect of selection for ethanol sensitivity on allosteric modulation of the GABA-A receptor.
authors.affiliation: Portland Alcohol Research Center, Portland, Oregon, USA.
authors.forename: Abraham A
authors.initials: AA
authors.lastname: Palmer
authors.forename: Carrie S
authors.initials: CS
authors.lastname: McKinnon
authors.forename: Hadley C
authors.initials: HC
authors.lastname: Bergstrom
authors.forename: Tamara J
authors.initials: TJ
authors.lastname: Phillips
mesh_terms: D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D018682:GABA Agents / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018079:Receptors, GABA / Q000235:genetics / Q000502:physiology*; D012641:Selection, Genetic
chemical_list: D000438:Alcohols; D002492:Central Nervous System Depressants; D018682:GABA Agents; D018079:Receptors, GABA; D000431:Ethanol