Synthesis and antifungal activity of 2,5-disubstituted-6-arylamino-4,7-benzimidazolediones.
2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Among them, 6-arylamino-5-chloro-2-(2-pyridyl)-4,7-benzimidazolediones exhibited potent antifungal activity against Candida species and Aspergillus niger.
-Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr
Song
Eun Ha
EH
Shim
Ju-Yeon
JY
You
Hea-Jung
HJ
Choi
Ko Un
KU
Choi
Ik Hwa
IH
Lee
Eun Young
EY
Chae
Mi Jin
MJ
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D001562:Benzimidazoles