title: Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa.
abstract: From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).
authors.affiliation: Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
authors.forename: Jeong Suk
authors.initials: JS
authors.lastname: Ko
authors.forename: Mun-Chual
authors.initials: MC
authors.lastname: Rho
authors.forename: Mi Yeon
authors.initials: MY
authors.lastname: Chung
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Song
authors.forename: Jong Seong
authors.initials: JS
authors.lastname: Kang
authors.forename: Koanhoi
authors.initials: K
authors.lastname: Kim
authors.forename: Hyun Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D051048:Diacylglycerol O-Acyltransferase; D032086:Evodia; D005638:Fruit / Q000737:chemistry; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C472153:1-methyl-2-(4,7-tridecadienyl)-4(1H)-quinolone; C472154:1-methyl-2-(6,9-pentadecadienyl)-4(1H)-quinolone; C472152:1-methyl-2-tetradecyl-4(1H)-quinolone; D000470:Alkaloids; D010936:Plant Extracts; D015363:Quinolones; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase