[Co-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma cell].
OBJECTIVE
To study the expression of immunoglobulin light chain kappa and lambda (Igkappa and Iglambda) in gastric carcinoma cell and their co-expression.


METHODS
Igkappa and Iglambda of 22 human gastric carcinoma specimens embedded in paraffin were monitored through immunohistochemical method-LSAB method.


RESULTS
Among 22 gastric carcinoma specimens, both Igkappa and Iglambda were positive in 17 (77.3%), only Igkappa was positive in 2 (9.1%), only Iglambda was positive in 1 (4.5%), both Igkappa and Iglambda negative in 2 (9.1%). The expression of Igkappa and Iglambda in human gastric carcinoma cell showed significant close correlation (chi(2) = 5.49, P < 0.05).


CONCLUSIONS
Co-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma cell is common, which suggests that the activation mechanism of immunoglobulin gene in gastric carcinoma cell may be different from that in B-lymphocytes. Study on co-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma is promising.
Yang
Shaobo
S
Department of Gastroenterology, South Building, General Hospital of PLA, Beijing 100853, China.
Wang
Mengwei
M
You
Weidi
W
D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis* / Q000235:genetics; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis* / Q000235:genetics; D007150:Immunohistochemistry; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism*
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains