title: Transient abnormal myelopoiesis in Noonan syndrome.
abstract: An infant affected by Noonan syndrome and presenting with abnormal hemopoiesis is described. Cytogenetic analysis, molecular studies, and in vitro culture assays ruled out myelodysplasia or other hematologic malignancies but were consistent with transient abnormal myelopoiesis. At present, 3 years and 10 months after diagnosis, the patient shows a normal hematologic picture. Supportive treatment in such patients, unless refractory cytopenias or overt leukemia develops, is emphasized.
authors.affiliation: Department of Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, Italy. cnr@pediatria.unito.it
authors.forename: Ferraris
authors.initials: F
authors.lastname: Silvio
authors.forename: Lanza
authors.initials: L
authors.lastname: Carlo
authors.forename: Barisone
authors.initials: B
authors.lastname: Elena
authors.forename: Bertorello
authors.initials: B
authors.lastname: Nicoletta
authors.forename: Farinasso
authors.initials: F
authors.lastname: Daniela
authors.forename: Miniero
authors.initials: M
authors.lastname: Roberto
mesh_terms: D006402:Hematologic Diseases / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009196:Myeloproliferative Disorders / Q000209:etiology*; D009634:Noonan Syndrome / Q000175:diagnosis*