title: Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches.
abstract: The formation of lymph nodes (LN) and Peyer's patches (PP) can be distinguished by the requirement of RANK for LN but not IL-7R(alpha), which is essential for PP development. However, lymphotoxin-alphabeta (LT(alpha)beta) signaling is required for both organs. The cellular basis underlying this dichotomy was revealed by the finding that the fetal IL-7R(alpha)(+) population responded equally well to IL-7 and RANKL to express LT(alpha)beta. IL-7R(alpha)(+) cells harvested from TRAF6(-/-) embryos expressed LTalphabeta in response to IL-7 but not RANKL, demonstrating that the RANK-TRAF6 signaling pathway regulates LT(alpha)beta expression in LN but not in PP. Soluble IL-7 administered to TRAF6(-/-) embryos was sufficient to restore LN genesis indicating the functional similarities of the IL-7R(alpha)(+) inducer cells for LN and PP genesis.
authors.affiliation: Division of Immunogenetics, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan. hyoshida@virus.kyoto-u.ac.jp
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Yoshida
authors.forename: Asuka
authors.initials: A
authors.lastname: Naito
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Inoue
authors.forename: Mizuho
authors.initials: M
authors.lastname: Satoh
authors.forename: Sybil M
authors.initials: SM
authors.lastname: Santee-Cooper
authors.forename: Carl F
authors.initials: CF
authors.lastname: Ware
authors.forename: Atsushi
authors.initials: A
authors.lastname: Togawa
authors.forename: Satomi
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nishikawa
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D005260:Female; D008198:Lymph Nodes / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000096:biosynthesis / Q000276:immunology*; D053308:Lymphotoxin-beta; D008565:Membrane Proteins / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010581:Peyer's Patches / Q000276:immunology*; D020395:Receptors, Interleukin-7 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: C505887:Ltb protein, mouse; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta; D008565:Membrane Proteins; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain