title: [Teicoplanin in the prophylaxis of surgical infections and bacterial endocarditis].
abstract: Antibiotic prophylaxis has become a standard of care in all surgical categories, since its impact in reducing the incidence of post-operative infections has now been well established. Antibiotic prophylaxis should target expected pathogens. Glycopeptide-based regimens have been considered a choice for surgical procedures, since Gram-positive bacteria are the pathogens most commonly isolated from wound infections. In orthopedics, cardiac, vascular and other clean surgical procedures, staphylococci (S. aureus and coagulase-negative staphylococci) are responsible for 70-90% of post-surgical infections. The isolation of methicillin-resistant strains has also risen to alarmingly high rates. This article focuses on the results of clinical trials on the efficacy of teicoplanin as prophylaxis in clean surgical procedures.
authors.affiliation: Fundación del Centro de Estudios Infectológicos (FUNCEI), French 3037, 1425 Buenos Aires, Argentina.
authors.forename: Francisco
authors.initials: F
authors.lastname: Nacinovich
authors.forename: Daniel
authors.initials: D
authors.lastname: Stamboulian
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D013504:Cardiovascular Surgical Procedures; D004697:Endocarditis, Bacterial / Q000517:prevention & control*; D006801:Humans; D019637:Orthopedic Procedures; D013530:Surgical Wound Infection / Q000517:prevention & control*; D017334:Teicoplanin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin