Neurosecretory and non-neurosecretory parvocellular neurones of the hypothalamic paraventricular nucleus express distinct electrophysiological properties.
Parvocellular neurones of the hypothalamic paraventricular nucleus (PVN) comprise neurosecretory and non-neurosecretory subpopulations. We labelled neurosecretory neurones with intravenous injection of the retrograde tracer, fluoro-gold, and recorded from fluoro-gold-positive and negative PVN parvocellular neurones in hypothalamic slices. Non-neurosecretory parvocellular neurones generated a low-threshold spike (LTS) and robust T-type Ca2+ current, whereas neurosecretory neurones showed no LTS and a small T-current. LTS neurones were located in non-neurosecretory regions of the PVN, and non-LTS neurones were located in neurosecretory regions of the PVN. These findings indicate that neurosecretory and non-neurosecretory subtypes of parvocellular PVN neurones express distinct membrane electrical properties.
Luther
J A
JA
Neuroscience Program, Molecular and Cellular Biology Program, and Neurobiology Division of the Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118-5698, USA.
Daftary
S S
SS
Boudaba
C
C
Gould
G C
GC
Halmos
K Cs
KC
Tasker
J G
JG
D000200:Action Potentials; D000818:Animals; D020747:Calcium Channels, T-Type / Q000502:physiology; D020644:Midline Thalamic Nuclei / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D051381:Rats
D020747:Calcium Channels, T-Type