Repetitive transcranial magnetic stimulation for Tourette syndrome.
In a single-blinded, placebo-controlled, crossover repetitive transcranial magnetic stimulation (rTMS) trial, 16 patients with Gilles de la Tourette syndrome (GTS) received in random sequence 1 Hz motor, premotor, and sham rTMS, which each consisted of two 20-minute rTMS sessions applied on 2 consecutive days. In the 12 patients who completed the trial, there was no significant improvement of symptoms after any of the rTMS conditions as assessed with the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey.
Münchau
A
A
Sobell Department of Neurophysiology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, UK.
Bloem
B R
BR
Thilo
K V
KV
Trimble
M R
MR
Rothwell
J C
JC
Robertson
M M
MM
D001007:Anxiety / Q000523:psychology; D018592:Cross-Over Studies; D003863:Depression / Q000523:psychology; D004574:Electromagnetic Fields; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D016037:Single-Blind Method; D005879:Tourette Syndrome / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome