title: Quality of life in multiple sclerosis patients in Spain.
abstract: OBJECTIVE
  The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain.
  
  
  METHODS
  The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores.
  
  
  RESULTS
  Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach's alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores.
  
  
  CONCLUSIONS
  The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.
authors.affiliation: Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA. chchang@northwestern.edu
authors.forename: C H
authors.initials: CH
authors.lastname: Chang
authors.forename: D
authors.initials: D
authors.lastname: Cella
authors.forename: O
authors.initials: O
authors.lastname: Fernández
authors.forename: G
authors.initials: G
authors.lastname: Luque
authors.forename: P
authors.initials: P
authors.lastname: de Castro
authors.forename: C
authors.initials: C
authors.lastname: de Andrés
authors.forename: B
authors.initials: B
authors.lastname: Casanova
authors.forename: M A
authors.initials: MA
authors.lastname: Hernández
authors.forename: J M
authors.initials: JM
authors.lastname: Prieto
authors.forename: V E
authors.initials: VE
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: de Ramón
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000523:psychology*; D011237:Predictive Value of Tests; D011594:Psychometrics; D011788:Quality of Life; D012044:Regression Analysis; D013030:Spain