The biotransformation of the diterpene 2beta-hydroxy-ent-13-epi-manoyl oxide by Gibberella fujikuroi.
Incubation of the diterpene 2beta-hydroxy-ent-13-epi-manoyl oxide with Gibberella fujikuroi afforded in good yield 2beta,6beta-dihydroxy-ent-13-epi-manoyl oxide, 2beta,12beta-dihydroxy-ent-13-epi-manoyl oxide and 2beta,20-dihydroxy-ent-13-epi-manoyl oxide, confirming that although ent-13-epi-manoyl oxide is a final metabolite of a biosynthetic branch in this fungus, more polar derivatives of this compound can be transformed by this micro-organism.
Fraga
Braulio M
BM
Instituto de Productos Naturales y Agrobiología, CSIC, P.O. Box 195, 38206-La Laguna, Tenerife, Canary Islands, Spain. bmfraga@ipna.csic.es
González
Pedro
P
Hernández
Melchor G
MG
Suárez
Sergio
S
D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D005874:Gibberella / Q000145:classification / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism
C473547:2-hydroxy-ent-13-epi-manoyl oxide; D004224:Diterpenes; D013729:Terpenes; C423905:ent-13-epi-manoyl oxide