A revised picture of the E2F transcriptional network and RB function.
New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and retinoblastoma action explain all of the functions of these proteins in vivo?
Stevaux
Olivier
O
Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Charlestown, MA 02129, USA.
Dyson
Nicholas J
NJ
D000818:Animals; D017209:Apoptosis; D001665:Binding Sites; D018797:Cell Cycle Proteins; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D018507:Gene Expression Regulation, Developmental; D008938:Mitosis; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D016160:Retinoblastoma Protein / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D014157:Transcription Factors