title: Making the connection: retinal axon guidance in the zebrafish.
abstract: Genetic screens in zebrafish have identified a large number of mutations that affect neural connectivity in the developing visual system. These mutants define genes essential for accurate retinal axon guidance in the eye and brain and the characterization of these mutants is helping to define the cellular and molecular mechanisms that guide axons in the vertebrate embryo. The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain.
authors.affiliation: Department of Biology, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: James
authors.initials: J
authors.lastname: Culverwell
authors.forename: Rolf O
authors.initials: RO
authors.lastname: Karlstrom
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics; D009154:Mutation; D016548:Prosencephalon / Q000196:embryology; D012160:Retina / Q000196:embryology* / Q000254:growth & development; D015027:Zebrafish / Q000196:embryology*