title: [Perturbations of activities of daily living in Alzheimer's disease. A study of 172 patients with the using a questionnaire completed by caregivers].
abstract: Functional decline was studied retrospectively in 172 patients with Alzheimer's disease, AD, using a questionnaire completed by the caregiver. Ninety-nine of these patients had a second assessment after a follow-up of 22.1 +/- 13.8 months. The questionnaire included French versions of the Physical Self-Maintenance Activities, ADL, and of the Instrumental Activities of Daily Living, IADL (Lawton and Brody, 1969). A third part assessing social activities, SADL, was derived from Katz and Lyerly (1963). The earliest and most frequent perturbations in early AD involved SADL, mainly a reduction in social and leisure activities, appearing in subjects with a MMSE score > 26. The earliest decline in IADL involved the ability for handling finances, odd jobs-sewing, and shopping, which were more frequently perturbed than ability to use telephone, traveling or handling medication. The most interesting results of our study were as follows. Functional decline did not allow to distinguish patients with early AD (MMSE score > or = 24) from those with mild dementia (MMSE score 20-23). Mild perturbations of ADL, mainly dressing and walking, were observed in early AD. There was a good correlation, but no parallelism, between functional decline and cognitive decline. Disturbances in ADL and SADL significantly differed only between patients with severe dementia (MMSE < 10) and those of the three other groups. Apathy appeared to be a stronger predictor of functional decline than the score on the MMSE in the early stages of AD. There was a great variability among the patients regarding the type of functional decline as well as the rate of decline. Functional decline is very useful for detecting early AD. However, its specificity seems to be low and the diagnosis should be supported by cognitive assessment.
authors.affiliation: Service de Neurologie, Pavillon Paul Castaigne, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris. chderou@noos.fr
authors.forename: C
authors.initials: C
authors.lastname: Derouesné
authors.forename: S
authors.initials: S
authors.lastname: Thibault
authors.forename: P
authors.initials: P
authors.lastname: Lozeron
authors.forename: V
authors.initials: V
authors.lastname: Baudouin-Madec
authors.forename: A
authors.initials: A
authors.lastname: Piquard
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000544:Alzheimer Disease / Q000523:psychology*; D017028:Caregivers; D003704:Dementia / Q000523:psychology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012727:Sex Characteristics; D012919:Social Behavior; D011795:Surveys and Questionnaires