title: Thyroid hormones levels in infants during and after cardiopulmonary bypass with ultrafiltration.
abstract: OBJECTIVE
  The aim of this study was to find out if infants after cardiopulmonary bypass develop non-thyroidal illness and if illness severity after cardiopulmonary bypass depends on hormone concentration in ultrafiltrate.
  
  
  METHODS
  Thyroid hormone status was assessed in 20 infants with congenital heart defects undergoing cardiac surgery (age range 7 days-11 months). Blood samples were collected preoperatively, during cardiopulmonary bypass, after cardiopulmonary bypass, and also postoperatively in 1, 2, 3, and 8 day after cardiac surgery. Plasma thyrotropin, thyroxine, free thyroxine, triiodothyronine, free triiodothyronine and reverse triiodothyronine were measured in blood samples and also in ultrafiltrate.
  
  
  RESULTS
  All patients had reduction in serum thyrotropin, thyroxine, free thyroxine, triiodothyronine, free triiodothyronine, and elevation of reverse triiodothyronine after cardiac surgery. In all patients we performed ultrafiltration. Patients were divided in to two groups. (with and without prolonged recovery). In the group of patients with prolonged recovery we noticed significantly higher amount of triiodothyronine per kilogram body weight. One of these patients died. The average level of total thyroxine decreased from the level 126 nmol/l before bypass to the minimal level 73 nmol/l after bypass, free thyroxine from the level 18 pmol/l before bypass to the minimal level 12 pmol/l after bypass. The average level of total triiodothyronine decreased from the level 1.54 nmol/l before bypass to the minimal level 0.42 nmol/l after bypass, free triiodothyronine from the level 6.12 pmol/l before bypass to the minimal level 3.21 pmol/l after bypass. The average level of TSH decreased from the level 4.31 mU/l before bypass to the level 0.64 mU/l after bypass. The average level of reverse-triiodothyronine increase from the level 0.83 nmol/l before bypass to the maximal level 1.94 nmol/l after bypass.
  
  
  CONCLUSIONS
  We conclude that non-thyroidal illness occurs in all infants after cardiopulmonary bypass. The amount of free triiodothyronine that is filtrated during cardiopulmonary bypass may influence postoperative recovery.
authors.affiliation: Department of Pediatric Cardiac Surgery, K. Marcinkowski University School of Medicine, ul. Fredry 10, 61-701 Poznan, Poland. rbart@mp.pl
authors.forename: R
authors.initials: R
authors.lastname: Bartkowski
authors.forename: M
authors.initials: M
authors.lastname: Wojtalik
authors.forename: E
authors.initials: E
authors.lastname: Korman
authors.forename: G
authors.initials: G
authors.lastname: Sharma
authors.forename: J
authors.initials: J
authors.lastname: Henschke
authors.forename: W
authors.initials: W
authors.lastname: Mrówczyński
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003422:Critical Care; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007432:Intraoperative Period; D011184:Postoperative Period; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014462:Ultrafiltration / Q000009:adverse effects*
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine