title: Metalloproteinase in myocardial adaptation and maladaptation.
abstract: Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metalloproteinases, membrane type matrix metalloproteinases, and disintegrin metalloproteinase play a significant role in these processes. The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy.
authors.affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Tyagi
authors.forename: Brian D
authors.initials: BD
authors.lastname: Hoit
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000201:enzymology; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D008666:Metalloendopeptidases