[99mTc-Pingyangmycin imaging in the diagnosis of primary lung cancer].
OBJECTIVE
To evaluate the clinical value of (99m)Tc-Pingyangmycin (PYM) imaging for the diagnosis of primary lung cancer.


METHODS
Radionuclide (99m)Tc-Pingyangmycin (PYM) imaging was performed in 56 patients with pulmonary lesions.


RESULTS
The uptake ratio and retention index (RI) were different in malignant and benign lesions. With the delayed ratio regarded as the threshold for lung cancer, the overall accuracy, sensitivity and specificity of (99m)Tc-PYM in the diagnosis of lung cancer were 82.1%, 82.7% and 80%, respectively. If RI was regarded as the threshold, the overall accuracy, sensitivity and specificity were 94.6%, 93% and 100%, respectively. There was no significant difference among different histological types of the lung carcinoma.


CONCLUSIONS
(99m)Tc-PYM, as a good imaging agent, is useful in differentiating malignant lung lesions from benign ones.
Zhang
Liangze
L
Department Theracic Surgical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Zhang
Rugang
R
Zhang
Dechao
D
Li
Jiaxiu
J
D000328:Adult; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000737:chemistry; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
D001761:Bleomycin; D013667:Technetium; C021771:zhengguangmycin