title: Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease.
abstract: Endolymphatic hydrops is the pathologic feature associated with Meniere's disease. The development of endolymphatic hydrops appears to arise from multifactorial inheritance with alteration of endolymphatic homeostasis. Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity.
authors.affiliation: Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA. papar001@tc.umn.edu
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Djalilian
mesh_terms: D000818:Animals; D015551:Autoimmunity; D004710:Endolymph / Q000502:physiology; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000209:etiology; D004712:Endolymphatic Sac / Q000502:physiology; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D008575:Meniere Disease / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D009154:Mutation; D013701:Temporal Bone / Q000473:pathology; D014667:Vasopressins / Q000502:physiology; D014777:Virus Diseases / Q000150:complications
chemical_list: D014667:Vasopressins