Surface expression of P-selectin on platelets is related with clinical worsening in acute ischemic stroke.
Platelet activation has a critical role in arterial disorders. In this study, we showed that the upregulation of P-selectin expression on platelets was related with clinical worsening in acute ischemic stroke. We serially (within 24 hr, at 72 hr, and 7 days) measured the expression of P-selectin on platelets in patients with acute ischemic stroke (n=45) and investigated the correlation between their extents and clinical severity of ischemic stroke. A significant relationship between the P-selectin expressions and National Institute of Health Stroke Scale (NIHSS) was observed at 72 hr and 7 days after ischemic stroke onset. Patients with clinical deterioration showed significantly increased expression of P-selectin on platelets as compared to those without deterioration. These results suggest that the P-selectin expression on platelets may contribute to the aggravation of clinical course in acute ischemic stroke. Thus, adequate manipulation of activated platelets is an important therapeutic strategy in acute ischemic stroke.
Cha
Jae-Kwan
JK
Department of Neurology, College of Medicine, Dong-A University, Busan, Korea. nrcjk@unitel.co.kr
Jeong
Min-Ho
MH
Kim
Eun-Kyung
EK
Lim
Yeong-Jin
YJ
Ha
Byung-Ryp
BR
Kim
Sang-Ho
SH
Kim
Jae Woo
JW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000473:pathology; D001792:Blood Platelets / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000096:biosynthesis* / Q000097:blood; D015398:Signal Transduction; D020521:Stroke / Q000378:metabolism; D013997:Time Factors; D015854:Up-Regulation
D015815:Cell Adhesion Molecules; D019007:P-Selectin