Tetanus immunity among pregnant women attending antenatal care in Dar es Salaam, Tanzania.
This study was conducted to investigate immunity to tetanus among pregnant women with verbal histories or documentation of having been vaccinated under the current five-dose tetanus toxoid (TT) schedule. It examined sera from 176 pregnant women attending antenatal care at Muhimbili Medical Centre in Dar es Salaam, Tanzania. Tetanus antitoxin level of 0.1 IU/ml was considered protective. Our findings show that 94.9% of women had tetanus antitoxin > or = 0.1 IU/ml. Multivariate analysis revealed that time after last vaccination, TT doses received and TT vaccination status explained 7.5%, 5.7% and 2.3% of variations in tetanus antitoxin levels respectively. Pregnant women with non-protective levels of tetanus antitoxin (5.1%) pose great risks of neonatal tetanus to their newborns and are also susceptible to maternal tetanus. Proper keeping of TT vaccination records is vitally important to avoid hyper-immunisation.
Aboud
S
S
Department of Microbiology and Immunology, Muhimbili University College of Health Sciences, P.O. Box 65007, Dar es Salaam, Tanzania. saboud@muchs.ac.tz
Lyamuya
E F
EF
Kristoffersen
E K
EK
Matre
R
R
D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D010298:Parity; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011295:Prenatal Care; D013636:Tanzania; D013742:Tetanus / Q000517:prevention & control* / Q000635:transmission; D013743:Tetanus Antitoxin / Q000097:blood; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination
D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid