Endogenous pro-inflammatory cytokines in children and adolescents during chemotherapy-induced neutropenia.
Monocyte-derived pro-inflammatory cytokines such as GM-CSF, IL-12, and IP-10 might protect patients with chemotherapy-induced neutropenia against infections. In settings with abundant neutrophils, G-CSF has been described as a suppressor of IL-12, but also as an inducer of GM-CSF. In 25 pediatric patients with chemotherapy-induced neutropenia the authors measured plasma levels of these four cytokines. GM-CSF was detectable in only a minority of patients (6/25). It was, however, positively correlated with high plasma levels of IL-12 and IP-10. G-CSF levels, however, were in no way correlated with the levels of any of these three cytokines.
Banning
U
U
University of Leipzig Medical Center, Department of Pediatrics, Leipzig, Germany. banu@medizin.uni-leipzig.de
Mauz-Körholz
C
C
Muhammad
Q
Q
Kösser
A
A
Müller
A E
AE
Tunn
U
U
Rieske
K
K
Bönig
H
H
Körholz
D
D
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D054357:Chemokine CXCL10 / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood*; D018664:Interleukin-12 / Q000097:blood; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D009503:Neutropenia / Q000139:chemically induced*
D000970:Antineoplastic Agents; D054357:Chemokine CXCL10; D016207:Cytokines; D018836:Inflammation Mediators; D016179:Granulocyte Colony-Stimulating Factor; D018664:Interleukin-12; D016178:Granulocyte-Macrophage Colony-Stimulating Factor