title: [Antibiotics resistance of Streptococcus pneumoniae. Results from the Brittany registry for 1999].
abstract: Throughout 1999, clinical microbiology laboratories of 13 hospitals in Brittany have recovered Streptococcus pneumoniae isolates in 832 patients, 312 (37.5%) female and 518 (62.2%) male. Two hundred fifty five of them (30.6%) were children. One hundred eighty eight isolates were recovered from blood cultures (22.6%), 16 from CSF (1.9%), 449 from lungs (54%), and 88 from ear exsudates (10.6%).A 5 microgram oxacillin-disk test was used to detect isolates with reduced susceptibility to penicillin G. Determination of MICs of penicillin G, amoxicillin and cefotaxime were then performed by agar dilution method on 402 strains previously categorized resistant or intermediate. Five hundred forty six isolates were PSDP, 33.5% of them were resistant to penicillin G, 2.2% to amoxicillin and 0.2% to cefotaxime. As expected, a decreased susceptibility to beta-lactamins was frequently associated with resistance to macrolides, cotrimoxazole and tetracycline. Among PSDP, the most prevalent serotypes were 23 (23.7%), 14 (23.5%) and 19 (19.1%). In Brittany, the constant rise of PSDP (1993-1994: 28.5%; 1997: 56.4%; 1999: 65.6 %) could be perhaps explain by analysis of social and demographic data.
authors.affiliation: Laboratoire de bactériologie-virologie-hygiène, CHU de Pontchaillou, 2, rue Henri Le Guilloux, 35033, Rennes, France. desborde@sunaimed.med.univ-rennes1.fr
authors.forename: L
authors.initials: L
authors.lastname: Desbordes
authors.forename: P Y
authors.initials: PY
authors.lastname: Donnio
authors.forename: J
authors.initials: J
authors.lastname: Vaucel
authors.forename: M L
authors.initials: ML
authors.lastname: Abalain
authors.forename: M
authors.initials: M
authors.lastname: Anguill
authors.forename: J P
authors.initials: JP
authors.lastname: Aubry
authors.forename: M J
authors.initials: MJ
authors.lastname: Dufour
authors.forename: J Y
authors.initials: JY
authors.lastname: Esvant
authors.forename: E
authors.initials: E
authors.lastname: Gardien
authors.forename: F
authors.initials: F
authors.lastname: Geffroy
authors.forename: C
authors.initials: C
authors.lastname: Heurtin
authors.forename: S
authors.initials: S
authors.lastname: Jaubert
authors.forename: A
authors.initials: A
authors.lastname: Gougeon
authors.forename: J L
authors.initials: JL
authors.lastname: Laborie
authors.forename: A
authors.initials: A
authors.lastname: Legac
authors.forename: G
authors.initials: G
authors.lastname: Lelay
authors.forename: J
authors.initials: J
authors.lastname: Minet
authors.forename: M
authors.initials: M
authors.lastname: Perrin
authors.forename: P
authors.initials: P
authors.lastname: Pouedras
authors.forename: H
authors.initials: H
authors.lastname: Sénéchal
authors.forename: H
authors.initials: H
authors.lastname: Sylvestre
authors.forename: D
authors.initials: D
authors.lastname: Tandé
authors.forename: J F
authors.initials: JF
authors.lastname: Ygout
authors.forename: J L
authors.initials: JL
authors.lastname: Avril
mesh_terms: D000328:Adult; D002648:Child; D004352:Drug Resistance, Microbial / Q000502:physiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology*; D012042:Registries; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D010400:Penicillin G