Vanadate inhibition of protein tyrosine phosphatases mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages.
Torres
Martine
M
Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, University of Southern California, Los Angeles California 90027, USA. mtorres@chla.usc.edu
Forman
Henry Jay
HJ
D000818:Animals; D002460:Cell Line; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014638:Vanadates / Q000494:pharmacology*
D017382:Reactive Oxygen Species; D014638:Vanadates; D006861:Hydrogen Peroxide; D020928:Mitogen-Activated Protein Kinases; D017027:Protein Tyrosine Phosphatases