Correlation between clinical syndromes and neuropsychological tasks in unmedicated patients with recent onset schizophrenia.
The aim of this study is to circumscribe the cognitive deficits according to schizophrenic syndromes in a population of sub-acute untreated patients. We have studied the cross-sectional correlation between cognitive deficits and schizophrenic symptoms, in a group of 24 untreated patients (including 17 neuroleptic-naive patients) with recent onset of the disease. A task of alertness, a working memory (WM) test (including two levels of difficulty) and an abbreviated version of the Wisconsin Card Sorting Test (WCST) were selected. WM deficits and poor performance on the WCST were highly correlated with disorganized symptoms, modestly with the positive syndrome and not with the negative syndrome. Thus, disorganized symptoms, more than any other, appear to be related to the impairment of executive function and WM in recent onset unmedicated patients with schizophrenia.
Daban
Claire
C
E0117 INSERM Paris V, Service Hospitalo-Universitaire, Hôpital Sainte-Anne, 7 rue Cabanis, 75014, Paris, France. daban@chsa.broca.inserm.fr
Amado
Isabelle
I
Baylé
Franck
F
Gut
Anne
A
Willard
Dominique
D
Bourdel
Marie-Chantal
MC
Loo
Henri
H
Olié
Jean-Pierre
JP
Millet
Bruno
B
Krebs
Marie-Odile
MO
Poirier
Marie-France
MF
D000208:Acute Disease; D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D012562:Schizophrenia, Disorganized / Q000150:complications*