Application of fungi as biocatalysts for the reduction of diethyl 1-oxoalkylphosphonates in anhydrous hexane.
Five different species of microorganisms, namely, Rhodotorula rubra, Rhodotorula glutinis, Cladosporium sp., Verticillium sp., and baker's yeast, turned out to be useful biocatalysts for enantioselective reduction of a variety of diethyl 1-oxoalkylphosphonates. To suppress substrate decomposition, bioreductions were carried out under anhydrous conditions, using lyophilized cells immobilized on Celite R 630. The influence of reaction conditions such as biotransformation time and chemical additives on the yield of the reaction is discussed.
Brzezińska-Rodak
Małorzata
M
Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wrocław, Poland.
Zymańczyk-Duda
Ewa
E
Kafarski
Paweał
P
Lejczak
Barbara
B
D001711:Biotransformation; D005612:Freeze Drying; D005658:Fungi / Q000378:metabolism*; D006586:Hexanes; D006865:Hydrogenation; D007659:Ketones / Q000378:metabolism; D063065:Organophosphonates / Q000378:metabolism*; D010084:Oxidation-Reduction; D012997:Solvents
D006586:Hexanes; D007659:Ketones; D063065:Organophosphonates; D012997:Solvents