Results of interval debulking surgery in advanced stage ovarian cancer: an exposed-non-exposed study.
BACKGROUND
To study the results of interval debulking surgery (IDS) in patients treated for 'unresectable' advanced stage ovarian cancer compared with primary debulking surgery (PDS) followed by chemotherapy.


METHODS
An exposed-non-exposed study including a group of 34 patients who underwent an IDS and were matched to an historic control group of 34 patients treated with PDS.


RESULTS
Optimal cytoreductive surgery was achieved in 94% (32 out of 34) of patients in both groups. The rates of post-operative morbidity, blood transfusion and median length of hospitalisation were significantly reduced in the study (IDS) group, but survival did not differ in both groups.


CONCLUSIONS
IDS in patients with advanced stage ovarian cancer offers the same chance of survival as PDS, but it is better tolerated.
Morice
P
P
Department of Surgery, Institut Gustave Roussy, Villejuif, France. morice@igr.fr
Brehier-Ollive
D
D
Rey
A
A
Atallah
D
D
Lhommé
C
C
Pautier
P
P
Pomel
C
C
Camatte
S
S
Duvillard
P
P
Castaigne
D
D
D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D005260:Female; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D011183:Postoperative Complications; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
D000970:Antineoplastic Agents