Global government applications of analogues, SARs and QSARs to predict aquatic toxicity, chemical or physical properties, environmental fate parameters and health effects of organic chemicals.
Faced with the need to predict physical and chemical properties, environmental fate, ecological effects and health effects of organic chemicals in the absence of experimental data, several Government organizations have been applying analogues, Structure Activity Relationships (SARs) and Quantitative Structure Activity Relationships (QSARs) to develop those predictions. To establish some benchmarks for monitoring future increases in applications of analogues, SARs and QSARs by global Government organizations, this paper describes the current applications of analogues, SARs and QSARs by Australian, Canadian, Danish, European, German, Japanese, Netherlands, and United States Government organizations to predict physical and chemical properties, environmental fate, ecological effects and health effects of organic chemicals.
Walker
J D
JD
TSCA Interagency Testing Committee (ITC), U.S. Environmental Protection Agency (7401M), 1200 Pennsylvania Avenue, NW Washington, DC 20460, USA. walker.johnd@epa.gov
Carlsen
L
L
Hulzebos
E
E
Simon-Hettich
B
B
D000818:Animals; D001315:Australia; D002170:Canada; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003718:Denmark; D064420:Drug-Related Side Effects and Adverse Reactions; D004784:Environmental Monitoring; D005060:Europe; D005858:Germany; D006076:Government; D007564:Japan; D009426:Netherlands; D021281:Quantitative Structure-Activity Relationship; D013329:Structure-Activity Relationship; D014481:United States; D014873:Water Pollutants
D014873:Water Pollutants