[The role of polychemotherapy in the management of malignant bone tumors].
Osteosarcoma,chondrosarcoma and Ewing tumors are the most common primary malignant bone tumors. Due to early hematogenous dissemination, surgery alone is able to cure less than 20% of patients with osteosarcoma. In Ewing-tumors less than 10% of patients will be cured with local treatment alone. By the use of aggressive polychemotherapy, given both pre- and post-surgery, cure rates of more than 50% for Ewing-tumors and about 70% for osteosarcoma could be achieved.Thus,chemotherapy is an indispensable part of the multimodal treatment of these tumor types. Chondrosarcomas are usually more highly differentiated and therefore show a lower rate of metastasis. The use of chemotherapy is not established in these tumors.
Reichardt
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P
Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Universitätsklinikum Charité, Campus Virchow-Klinikum, Humboldt-Universität zu Berlin. peter.reichardt@charite.de
Dörken
B
B
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002813:Chondrosarcoma / Q000188:drug therapy* / Q000601:surgery*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000601:surgery*; D013997:Time Factors