Generation and use of an equivalent of difluoroacetamide or difluoroacetate anions.
Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.
Blond
Gaëlle
G
Laboratoire SERCOF (UMR CNRS 5622) Université Claude Bernard-Lyon 1 Bât. Chevreul 43, Bd du 11 novembre 1918, 69622 Villeurbanne, France.
Billard
Thierry
T
Langlois
Bernard R
BR
D000577:Amides / Q000138:chemical synthesis; D017611:Fluorine Compounds / Q000138:chemical synthesis / Q000737:chemistry; D005463:Fluoroacetates / Q000138:chemical synthesis*
D000577:Amides; D017611:Fluorine Compounds; D005463:Fluoroacetates; C027495:difluoroacetic acid