IS6110 fingerprinting of sensitive and resistant strains (1991-1992) of Mycobacterium tuberculosis in Colombia.
The standardized method to study the polymorphism of IS 6110 was used to characterize 53 isolates of Mycobacterium tuberculosis obtained during 1991-1992 from 14 regions in Colombia. In Valle region cluster rate was 25% (4/16). The mean number of IS6110 band was 10 +/- 3. Similarity between strains was of 60% in 81% of strains and this tended to be correlated with geographic origin. For the first time M. tuberculosis without IS6110 bands in restriction fragment length polymorphism analysis was found in Colombia. Additional studies are necessaries in order to best characterize the situation in relation to human immunodeficiency virus epidemic and recent changes in tuberculosis control program.
Gómez-Marin
Jorge Enrique
JE
Centro de Investigaciones Biomedicas, Facultad de Medicina, Universidad del Quindio, Colombia. jegomezmarin@hotmail.com
Leon Franco
Clara Inés
CI
Inirida Guerrero
Martha
M
Rigouts
Leen
L
Portaels
Françoise
F
D016000:Cluster Analysis; D003105:Colombia; D016172:DNA Fingerprinting; D004251:DNA Transposable Elements / Q000235:genetics*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D004251:DNA Transposable Elements