[Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene].
OBJECTIVE
To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene.


METHODS
Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls.


RESULTS
Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017).


CONCLUSIONS
The results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.
Cao
Liping
L
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. coolliping@yahoo.com.cn
Li
Tao
T
Xu
Ke
K
Liu
Xiehe
X
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006556:Heroin Dependence / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D004247:DNA; D002394:Catechol O-Methyltransferase; D004262:DNA Restriction Enzymes