title: The orbitofrontal cortex in methamphetamine addiction: involvement in fear.
abstract: We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction.
authors.affiliation: Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA. rgoldstein@bnl.gov
authors.forename: Rita Z
authors.initials: RZ
authors.lastname: Goldstein
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.forename: Linda
authors.initials: L
authors.lastname: Chang
authors.forename: Gene-Jack
authors.initials: GJ
authors.lastname: Wang
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Fowler
authors.forename: Richard A
authors.initials: RA
authors.lastname: Depue
authors.forename: Ruben C
authors.initials: RC
authors.lastname: Gur
mesh_terms: D000328:Adult; D000367:Age Factors; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D016728:Self-Injurious Behavior / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D008694:Methamphetamine; D005947:Glucose