Efficacy of sequential chemotherapy including methotrexate and doxorubicin in an infant with partially resected choroid plexus carcinoma.
This report refers to a 3-month-old male, with a residual choroid plexus carcinoma following partial resection, who was successfully treated with sequential chemotherapy without any postoperative radiation therapy. Along with carboplatin, we also used doxorubicin and methotrexate, hypothesizing that, given the patient's age, the blood-brain barrier should not hamper drug delivery to the tumor. According to this hypothesis, the treatment achieved complete remission of the disease, which lasts 27 months after the diagnosis. This result deserves further studies to assess the possible curative role of chemotherapy in very young patients suffering from choroid plexus carcinoma.
Fiorillo
Amedeo
A
Department of Pediatrics, University Federico II, Via S. Pansini 5, I-80131 Naples, Italy. afiorill@unina.it
Maggi
Giuseppe
G
Cirillo
Sossio
S
Migliorati
Roberta
R
Buffardi
Floriana
F
Alfieri
Elvira
E
Sabbatino
M Simona
MS
D'Amico
Alessandra
A
DelBasso DeCaro
M Laura
ML
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage* / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D016545:Choroid Plexus Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin; D016190:Carboplatin; D008727:Methotrexate