Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1.
Migraine is the most common type of chronic episodic headache. To find novel susceptibility genes for familial migraine with and without aura, a genomewide screen was performed in a large family from northern Sweden. Evidence of linkage was obtained on chromosome 6p12.2-p21.1, with a maximum two-point lod score of 5.41 for marker D6S452. The patients with migraine shared a common haplotype of 10 Mb between markers D6S1650 and D6S1960.
Carlsson
A
A
Umeå Centre for Molecular Medicine, University of Umeå, Sweden.
Forsgren
L
L
Nylander
P-O
PO
Hellman
U
U
Forsman-Semb
K
K
Holmgren
G
G
Holmberg
D
D
Holmberg
M
M
D000328:Adult; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics* / Q000503:physiopathology; D020326:Migraine without Aura / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D013548:Sweden
D005819:Genetic Markers; D004247:DNA