title: [The effect of acute urinary retention on serum prostate specific antigen concentration].
abstract: OBJECTIVE
  To study the effect of acute urinary retention on the serum prostate-specific antigen (PSA) concentration.
  
  
  METHODS
  Blood samples from 34 benign prostatic hyperplasia (BPH) patients with acute urinary retention were drawn immediately before suprapubic cystomy and 48 hours after relief of urinary retention. Serum PSA concentrations were measured with radioimmunoassay.
  
  
  RESULTS
  The mean serum PSA levels of BPH patients with acute urinary retention was (24.6 +/- 16.1) micrograms/L (range from 2.6 micrograms/L to 45.8 micrograms/L). Forty-eight hours after relief of urinary retention, the mean serum PSA levels declined to (9.4 +/- 6.3) micrograms/L (range from 1.7 micrograms/L to 16.6 micrograms/L). The difference was significant (P < 0.01).
  
  
  CONCLUSIONS
  Acute urinary retention could dramatically increase the serum PSA value of patients with BPH. After relief of the urinary retention, the patients had a great than 50% decreased of PSA values.
authors.affiliation: Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Hua
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Wu
authors.forename: Yuan-Geng
authors.initials: YG
authors.lastname: Sui
authors.forename: Shuang-Guan
authors.initials: SG
authors.lastname: Cheng
authors.forename: Zhen-Quan
authors.initials: ZQ
authors.lastname: Xu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*; D016055:Urinary Retention / Q000097:blood*
chemical_list: D017430:Prostate-Specific Antigen