title: Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease.
abstract: OBJECTIVE
  In this study we aimed to determine the levels of Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) in patients with inflammatory bowel disease (IBD) to investigate their contribution to tissue injury in inflammatory bowel disease.
  
  
  METHODS
  Forty-seven GSH-Px patients (35 with ulcerative colitis and 12 with Crohn's disease) and 30 healthy controls were included in the study. Their plasma and MDA levels were compared using nonparametric statistical methods.
  
  
  RESULTS
  Plasma GSH-Px levels of the patients group were significantly higher than the control group (p < 0.001). There was no significant difference between patients and controls in view of plasma levels of MDA.
  
  
  CONCLUSIONS
  High levels of GSH-Px, which is response against oxidative stress, indicates the increase of free radicals in IBD, while normal plasma MDA levels suggest the clearance of free radicals without leading to lipid peroxidation. Our result reveals that there is an existing antioxidant capacity despite oxidative stress in patients with IBD.
authors.affiliation: Department of Gastroenterology, Gülhane Medical Academy and Medical Faculty, 06018 Etlik, Ankara, Turkey. ahmettuzun@yahoo.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tüzün
authors.forename: Ahmet
authors.initials: A
authors.lastname: Erdil
authors.forename: Volkan
authors.initials: V
authors.lastname: Inal
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aydin
authors.forename: Sait
authors.initials: S
authors.lastname: Bağci
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yeşilova
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sayal
authors.forename: Necmettin
authors.initials: N
authors.lastname: Karaeren
authors.forename: Kemal
authors.initials: K
authors.lastname: Dağalp
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000097:blood* / Q000201:enzymology; D003424:Crohn Disease / Q000097:blood* / Q000201:enzymology; D003627:Data Interpretation, Statistical; D005260:Female; D005609:Free Radicals / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D005609:Free Radicals; D008315:Malondialdehyde; D005979:Glutathione Peroxidase