[Effect of hepatic arterial infusion chemotherapy for liver metastasis from gastric cancer].
We performed hepatic arterial infusion (HAI) chemotherapy for 4 patients with advanced gastric cancer who had undergone curative resection except for liver metastasis. The main antineoplastic drugs were 5-fluorouracil (5-FU), mitomycin C (MMC) and cisplatin (CDDP). A catheter was inserted into the hepatic artery by interventional radiological techniques in 3 patients and operatively in 1 patient. The response rate for 4 patients was 75% (CR2, PR1, PD1). The adverse events were Grade 3/4 nausea and/or vomiting in 2 cases. The HAI chemotherapy was effective and useful for patients with advanced gastric cancer who had no unresectable lesions except for liver metastasis.
Shizawa
Ryoichi
R
Dept. of Surgery, Yokosuka Kyousai Hospital.
Nagahori
Yutaka
Y
Kumamoto
Nobufumi
N
Yamamoto
Harumi
H
Takeda
Kazunaga
K
Hamaguchi
Youhei
Y
Fukushima
Tadao
T
Yamamoto
Masayoshi
M
Mogaki
Masatoshi
M
Fukasawa
Shingo
S
Eguchi
Kazuya
K
Kawahara
Masaki
M
Nagahori
Kaoru
K
Hosoi
Hideo
H
Ohara
Takeshi
T
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil