title: [Selection for disease resistance in domestic ruminants and swine by indicator traits as well as marker and causal genes--a review. Part 1: Short introduction to immunogenetics of MHC and non-MHC genes and special immunogenetics of cattle and swine].
abstract: The introduction deals with immunogenetic investigations on the field of life-stock. The main chapter is outlined as a tabular overview of current opportunities of the application of indicator traits as well as marker and causal genes in breeding for disease resistance in cattle, sheep, goats and swine. In the discussion of the second part, emphasis was layed on diseases of small ruminants in central and western Europe. Indicator traits are discussed with respect of their advantages and disadvantages. The rigorous selection of specific traits is connected with an increase of the number of homozygotes. In contrary, pathogens do undergo mutations, thus escaping the host's immune system. Out of this point of view it is advisable, to set on selection very cautiously. The role of technologies of modern immunogenetics is pointed out in respect of constructing disease resistant animals.
authors.affiliation: II. Medizinischen Universitätsklinik für Klauentiere der Veterinärmedizinischen Universität Wien.
authors.forename: W
authors.initials: W
authors.lastname: Sipos
authors.forename: F
authors.initials: F
authors.lastname: Schmoll
authors.forename: K
authors.initials: K
authors.lastname: Wimmers
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility / Q000662:veterinary; D005260:Female; D015511:Goat Diseases / Q000235:genetics / Q000276:immunology; D006041:Goats; D007113:Immunity, Innate / Q000235:genetics; D007125:Immunogenetics; D008297:Male; D012641:Selection, Genetic; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000235:genetics / Q000276:immunology