C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.
The aim of the present study was to investigate the relationship between C-reactive protein (CRP) and insulin resistance in non-obese Japanese type 2 diabetic patients. A total of 135 non-obese Japanese type 2 diabetic patients (96 men and 39 women, aged 36 to 83 years, with a body mass index [BMI] of 16.2 to 26.8 kg/m2) were studied. BMI, glycosylated hemoglobin (HbA(1c)), fasting concentrations of plasma glucose, serum lipids (triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol, and total cholesterol), CRP, and fibrinogen were measured. LDL cholesterol was calculated using the Friedewald formula. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Univariate regression analysis showed that CRP value was positively correlated to age (r = 0.218, P =.012), BMI (r = 0.239, P =.006), HOMA-IR (r = 0.397, P <.0001), triglycerides (r= 0.310, P <.005), LDL cholesterol (r= 0.179, P =.038), and fibrinogen (r = 0.371, P <.0001) levels and inversely correlated to HDL cholesterol (r = 0.174, P =.044) level in our diabetic patients. Multiple regression analysis showed that CRP was independently predicted by HOMA-IR (P<.0001, F = 11.6) and fibrinogen (P<.0001, F = 34.2), which explained 23.5% of the variability of CRP in our non-obese Japanese type 2 diabetic patients. These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients.
Taniguchi
Ataru
A
Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan.
Nagasaka
Shoichiro
S
Fukushima
Mitsuo
M
Sakai
Masahiko
M
Okumura
Takahide
T
Yoshii
Satoru
S
Watanabe
Toshiki
T
Ogura
Masahito
M
Yamadori
Noriko
N
Nin
Kazuko
K
Kuroe
Akira
A
Yamada
Yuichiro
Y
Seino
Yutaka
Y
Nakai
Yoshikatsu
Y
D044466:Asian People; D002097:C-Reactive Protein; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013851:Thinness
D008055:Lipids; D005340:Fibrinogen; D002097:C-Reactive Protein