[Adrenomedullin in pregnancy].
In this study, we used the animal model of preeclampsia. The blood pressure in animals receiving L-NAME at 25 mg/day were significantly higher compared to that of rats receiving saline solution only. In addition, L-NAME treated rats showed a high fetal mortality as compared with intact rats. Also, we demonstrated infusion of AM reverse the hypertension and decrease in pup mortality induced by L-NAME during pregnancy. We showed that the AM mRNA levels predominantly exists in a high level in the placenta, uterus and ovary as compared with other tissues. These evidences suggest that AM may have a possible important role during pregnancy. In conclusion, the present study suggest that L-NAME-induced elevated blood pressure and increased fetal mortality can be reversed by low dose of AM. Thus AM may play an important role in the regulation of blood pressure, the blood supply to the utero-placental unit and fetal development.
Makino
Ikuko
I
Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Shibata
Kazuhiko
K
Makino
Yasuo
Y
Kawarabayashi
Tatsuhiko
T
D053607:Adrenomedullin; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D021041:Placental Circulation / Q000187:drug effects; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides; D012333:RNA, Messenger; D053607:Adrenomedullin