title: Pharmacotechnical characterization and effectiveness testing of a proposed emulsion for the treatment of dry skin.
abstract: One of the most important objectives of the Pharmaceutical Industry is the development of new excipients as well as the optimization of other more traditional ones. Also, the investigation of new active substances able to prevent, palliate or treat the cutaneous dehydration is another of the most important of their objectives. Both tendencies are implanted in this experimental work: we propose an emulsion formulated with the base--Neo PCL' (25%), NMF (Lactil', 5%) and a peculiar active--Honey of Rosemary (15%). The working scheme is as follows: 1) Pharmacotechnical Characterization--organoleptic characteristics, Photomicrograph Study, Type of Emulsion, pH, Rheology; 2) Stability Study by means of accelerated tests based on temperature and centrifugation; 3) Effectiveness Study by applying of non-invasive assessment techniques. An emulsified dermopharmaceutical form is obtained (O/W) with a satisfactory organoleptic characteristics and eudermic pH (5.2), attributable to the acid character of Honey. From the rheological study, a very good results are obtained: viscosity (T = 408.8.D0.549), structural recuperation (30%) and thixotropy (AD1/AD2 = 1.36). On the other hand, from the effectiveness results (corneometric--P.I.120 = 43.2%- and sebumetric--E.I. = 33-144 mg/cm2-), a high level of moisturizing is deduced, which is attributable to the synergic action of both Lactil' and Honey. Finally, the proposed emulsion would serve as a treatment for all type of dry skin.
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Alcalá University, Madrid, Spain.
authors.forename: M M
authors.initials: MM
authors.lastname: Jiménez
authors.forename: M J
authors.initials: MJ
authors.lastname: Fresno Contreras
authors.forename: E
authors.initials: E
authors.lastname: Sellés
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D003681:Dehydration / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004339:Drug Compounding; D004355:Drug Stability; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D009823:Ointment Bases; D012212:Rheology; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D004655:Emulsions; D009823:Ointment Bases