Parameters of coagulant and fibrinolytic capacity and activity in postmenopausal women: within-subject variability.
We have analyzed the within-subject variability of a battery of parameters of coagulant and fibrinolytic capacity and activity in postmenopausal women. We observed large differences in within-subject variability among the tests and have demonstrated how such data can be used to estimate the number of times a parameter must be measured to produce a statistically adequate sample.
Horne
McDonald K
MK
Department of Laboratory Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. mhorne@mail.cc.nih.gov
McCloskey
Donna Jo
DJ
Cullinane
Ann M
AM
Merryman
Paula K
PK
Rick
Margaret E
ME
Hortin
Glen L
GL
Waclawiw
Myron A
MA
Cannon
Richard O
RO
D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis; D005165:Factor V; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood; D008137:Longitudinal Studies; D017698:Postmenopause / Q000097:blood*; D015203:Reproducibility of Results
D015415:Biomarkers; D001779:Blood Coagulation Factors; C095381:factor V Leiden; D005165:Factor V