New and efficient synthesis of azabicyclo[4.4.0]alkane amino acids by Rh-catalyzed cyclohydrocarbonylation.
[reaction: see text] Highly efficient syntheses of azabicyclo[4.4.0]alkane amino acids were achieved by Rh-catalyzed cyclohydrocarbonylation of dipeptides bearing a terminal olefin moiety and a heteroatom nucleophile.
Mizutani
Nobuhiro
N
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Chiou
Wen-Hua
WH
Ojima
Iwao
I
D000596:Amino Acids / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry; D018716:Molecular Mimicry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary; D012238:Rhodium / Q000737:chemistry
D000596:Amino Acids; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004151:Dipeptides; D010456:Peptides, Cyclic; D012238:Rhodium