Nosocomial transmission of Saccharomyces cerevisiae in bone marrow transplant patients.
Saccharomyces cerevisiae is an unusual cause of clinical infection. We describe three bone marrow transplant patients on a haematology unit who developed possible invasive disease with the organism. Two patients died and both these patients appeared to have a related strain of S. cerevisiae. Screening for S. cerevisiae from throat and stool samples revealed four further patients who were carriers. Genotyping of the invasive and carriage strains demonstrated an indistinguishable strain from patients who had been on the unit at the same time, suggesting cross-infection.
Olver
W J
WJ
Department of Microbiology, City Hospital, Nottingham, UK. Will.Olver@nottingham.ac.uk
James
S A
SA
Lennard
A
A
Galloway
A
A
Roberts
I N
IN
Boswell
T C
TC
Russell
N H
NH
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002353:Carrier State / Q000635:transmission*; D003428:Cross Infection / Q000188:drug therapy / Q000209:etiology* / Q000635:transmission*; D004271:DNA, Fungal / Q000032:analysis; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005243:Feces / Q000382:microbiology; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D005838:Genotype; D006801:Humans; D016867:Immunocompromised Host; D017053:Infection Control; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D008403:Mass Screening; D009102:Multiple Organ Failure / Q000382:microbiology; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology* / Q000635:transmission*; D010614:Pharynx / Q000382:microbiology; D012441:Saccharomyces cerevisiae / Q000235:genetics
D000935:Antifungal Agents; D004271:DNA, Fungal; D000666:Amphotericin B; D005437:Flucytosine