title: [Chemoradiotherapy using platinum analogs/5-FU for advanced esophageal cancer].
abstract: We evaluated the efficacy of concurrent chemoradiotherapy (CRT) using cisplatin/nedaplatin and 5-FU for advanced esophageal cancer. Thirteen patients with locally advanced esophageal cancer (T4 cases) and 3 with recurrence of esophageal cancer were treated with radiotherapy (40-70 Gy) and 5-FU combined with cisplatin/nedaplatin concurrently. T4 patients who obtained down-staging by CRT also underwent esophagectomy. A complete response was obtained in one case, partial response in 8 cases, and no change in 7 cases. The overall response rate was 56.3%. A pathological complete response was obtained in one case in which curative resection was performed after CRT. Bone marrow suppression was observed in 68.8% and grade 3 and 4 bone marrow suppression was observed in 43.8%. Concurrent CRT using cisplatin/nedaplatin and 5-FU for advanced esophageal cancer has a high response rate and patients obtaining down-staging by CRT as a neoadjuvant therapy have a chance for long survival after curative resection in locally advanced cases.
authors.affiliation: Second Dept. of Surgery, School of Medicine, Hirosaki University.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Shibata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakai
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsuya
authors.forename: Kyougo
authors.initials: K
authors.lastname: Yamada
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morita
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; C053989:nedaplatin; D002945:Cisplatin; D005472:Fluorouracil