[The introduction of preoperative staging laparoscopy and molecular diagnosis of peritoneal lavages for the treatment of advanced gastric cancer].
In this study, intra-peritoneal chemotherapy was performed for advanced gastric cancer with serosal invasion. We assessed the efficacy of the chemotherapy using quantitative genetic diagnosis with peritoneal lavages collected before and after chemotherapy at staging laparoscopy and/or gastrectomy. Cases in which genetic diagnosis of peritoneal lavages showed negative results, or changed from positive to negative after chemotherapy, had a good prognosis. On the other hand, cases in which genetic diagnosis showed positive results after chemotherapy had worse prognosis. Intra-peritoneal chemotherapy may be indicated for patients with a positive genetic diagnosis only and cases becoming negative as a result of this therapy may have a better prognosis.
Fujiwara
Yoshiyuki
Y
Dept. of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University.
Takiguchi
Shuji
S
Mori
Takuji
T
Yasuda
Takushi
T
Yano
Masahiko
M
Monden
Morito
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D010535:Laparoscopy; D008558:Melphalan / Q000008:administration & dosage; D009367:Neoplasm Staging / Q000379:methods*; D010533:Peritoneal Lavage; D011379:Prognosis; D012673:Semustine / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
D012673:Semustine; D003520:Cyclophosphamide; D002945:Cisplatin; D008558:Melphalan