Enhancement of combinatorial chemistry by microwave-assisted organic synthesis.
It was in the 1980 s that the first papers in which the use of either combinatorial methods or microwave heating in organic chemistry were published. Unlike combinatorial chemistry, which quite readily became an accepted method, particularly in the pharmaceutical industry, it is only now that microwave heating is truly gaining acceptance. Our aim in this review is to attempt to rationalize this slow acceptance and to show the benefits to be gained by employing microwave heating in tandem with combinatorial chemistry. We will also give a number of examples of successful applications.
Lidström
Pelle
P
Personal Chemistry Ltd, Lincoln House, The Paddocks, 347 Cherry Hinton Road, Cambridge, CB1 8DH, UK. pelle.lidstrom@personalchemistry.com
Westman
Jacob
J
Lewis
Anthony
A
D002625:Chemistry, Organic / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis
D007202:Indicators and Reagents; D009930:Organic Chemicals