Modeling force development in the sarcomere in consideration of electromechanical coupling.
Models of the cellular force development simulate the contractive behavior of the sarcomere. In conjunction with electrophysiological models they can contribute to a better comprehension of physiology and pathologies. Aim of this study is to examine the coupling of cellular electrophysiological processes and force development. For that a graphical user interface was developed to simplify the parameterization and calculation of the models as well as to present the results graphically. A feedback mechanism is introduced to pay attention to close connections between force development and intracellular processes. On basis of various tests with different boundary conditions, new force models are developed, parameterized, validated and compared with models in literature. In future studies the results will be tested in multiple cell organization.
Glänzel
K
K
Institut für Biomedizinische Technik, Universität Karlsruhe (TH), Germany. kerstin.glaenzel@ibt.uni-karlsruhe.de
Sachse
F B
FB
Seemann
G
G
Riedel
C
C
Dössel
O
O
D000199:Actins / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D003196:Computer Graphics; D003198:Computer Simulation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D009218:Myosins / Q000502:physiology; D012518:Sarcomeres / Q000502:physiology*; D014335:Tropomyosin / Q000502:physiology; D014336:Troponin / Q000502:physiology
D000199:Actins; D015220:Calcium Channels; D014335:Tropomyosin; D014336:Troponin; D000255:Adenosine Triphosphate; D009218:Myosins