A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.
Wu
Xu
X
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Ding
Sheng
S
Ding
Qiang
Q
Gray
Nathanael S
NS
Schultz
Peter G
PG
D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D008648:Mesoderm / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008809:Mice, Inbred C3H; D009025:Morpholines / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D010012:Osteogenesis / Q000187:drug effects*; D011687:Purines / Q000494:pharmacology*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology
D009025:Morpholines; D011687:Purines; D000469:Alkaline Phosphatase; C470893:purmorphamine