Efferent control of different visceral pelvic organs by spinal and supraspinal centres.
A growing number of patients with pelvic organ dysfunction and failing response to standard treatment concepts are referred to special neuro-urology services. New therapeutic options are available, such as unilateral and bilateral sacral nerve stimulation, and the use of different neurotoxins for the overactive bladder. However, a lack of knowledge and understanding in central innervation and modulation of pelvic organ function prevents a striking progress in this clinical area. A concept of efferent innervation of pelvic organs based on experimental animal studies, using the retrograde, transneuronal and self-amplifying tracer Pseudorabiesvirus, is discussed in a clinical context.
Zermann
Dirk-Henrik
DH
dh.zermann@med.uni-jena.de
D000818:Animals; D004525:Efferent Pathways / Q000502:physiology*; D011558:Herpesvirus 1, Suid; D006801:Humans; D008297:Male; D011467:Prostate / Q000294:innervation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000502:physiology; D001743:Urinary Bladder / Q000294:innervation*; D014563:Urodynamics / Q000502:physiology