Hydrogen bond-stabilized helix formation of a m-phenylene ethynylene oligomer.
[reaction: see text] Incorporation of a single hydrogen bonded beta-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.
Cary
Jennifer M
JM
Department of Chemistry and Materials Science, The University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Moore
Jeffrey S
JS
D000480:Alkynes / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D018716:Molecular Mimicry; D011108:Polymers / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D000480:Alkynes; D004987:Ethers; D011108:Polymers; D012997:Solvents; C436384:phenyleneethynylene