[Study on the male contraceptive based on epididymis].
More and more study on the epididymal function and sperm maturation has shown that epididymis will be one of the best target organs of male contraception, although at present there is not a male contraceptive medicine based on epididymis for clinical practice. The promoting research aspects in epididymal contraception in animal included affecting directly epididymis (such as Sulpasalazine), interfering energy metabolism and sperm mobility (such as Chlorinated Glycerol), altering the internal environment of epididymis (such as copper particles and TW19). The epididymal specific proteins could bring out some new target antigens for immunological contraception, to produce contraceptive vaccine. Some special genes, which expressed distinctively in epididymis such as SC342, bin1, have been cloned and studied on their function. These works would be helpful not only for clinical diagnosis and treatment of epididymitis and male infertility, but also for male contraceptive research and progress.
Cui
Yu-Gui
YG
Key Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Tong
Jian-Sun
JS
Wang
Xing-Hai
XH
D003267:Contraception; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D004822:Epididymis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D013079:Sperm Maturation / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects
D003272:Contraceptive Agents, Male