Anti-herpes simplex virus effect of a seed extract from the tropical plant Licania tomentosa (Benth.) Fritsch (Chrysobalanaceae).
Incubation of acyclovir-resistant herpes simplex virus type 1 (ACVr-HSV1), during infection of the HEp-2 cell culture, with an extract prepared from the seeds of Licania tomentosa (Benth.) Fritsch (Chrysobalanaceae) species impaired the productive replication of this virus in a concentration-dependent manner. The extract was able to inhibit extracellular virus (virucidal effect) and also interfered with a very early event of cell infection, at a non-cytotoxic concentration.
Miranda
M M F S
MM
Departamento de Virologia Prof. Paulo de Góes Instituto de Microbiologia, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Rio de Janeiro, Brasil. mmfsm@micro.ufrj.br
Gonçalves
J L S
JL
Romanos
M T V
MT
Silva
F P
FP
Pinto
L
L
Silva
M H
MH
Ejzemberg
R
R
Granja
L F Z
LF
Wigg
M D
MD
D000998:Antiviral Agents / Q000494:pharmacology*; D001938:Brazil; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D019685:Rosales; D012639:Seeds / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D010936:Plant Extracts