MR-pathologic correlation of lung specimens.
The aim of this study was to assess the feasibility of a new MR-pathologic correlation method utilizing a high-resolution MR technique with a 3-inch surface coil and elimination of susceptibility by replacing air in the pulmonary alveoli of lung specimens with water. Inflated cadaver lung specimens of various lung disorders were imaged using a conventional spin echo (SE) sequence in a clinical 1.5 T MR scanner. The MR images were correlated with pathologic specimens. In six out of seven specimens, MR revealed detailed images corresponding to pathological changes. MR may provide a non-invasive and non-destructive method for examining lung specimens and for image-pathologic correlation.
Hatabu
Hiroto
H
Department of Radiology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. hhatabu@caregroup.harvard.edu
Uematsu
Hidemasa
H
Hasegawa
Ichiro
I
Itoh
Harumi
H
D002102:Cadaver; D005240:Feasibility Studies; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*