title: Efficacy of liposome-encapsulated ciprofloxacin compared with ciprofloxacin and ceftriaxone in a rat model of pneumococcal pneumonia.
abstract: Encapsulation of ciprofloxacin in sterically stabilized liposomes results in a prolonged circulation time and improved pharmacokinetics. Liposome-encapsulated ciprofloxacin was compared with conventional ciprofloxacin and ceftriaxone in a rat model of pneumococcal pneumonia. Male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumoniae and then treated with intravenous ceftriaxone (100 mg/kg), ciprofloxacin (40 or 80 mg/kg) or liposomal ciprofloxacin (40 or 80 mg/kg) administered once or twice daily for 3 days. White blood counts, development of bacteraemia and mortality were measured for 10 days. Antibiotic concentrations in serum, lung lavage fluid and white blood cells recovered from lung lavage fluid were determined. Liposomal ciprofloxacin concentrations were significantly higher in serum and lavage fluid compared with conventional ciprofloxacin, resulting in greater area under the serum concentration-time curve and maximum serum concentration. Despite these higher concentrations, survival rates were similar between groups treated with equivalent doses of liposomal ciprofloxacin versus ciprofloxacin. When antibiotics were given once daily, ceftriaxone was more effective than either form of ciprofloxacin.
authors.affiliation: Infectious Diseases Section, Omaha, NE 68105, USA.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Ellbogen
authors.forename: Keith M
authors.initials: KM
authors.lastname: Olsen
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Gentry-Nielsen
authors.forename: Laurel C
authors.initials: LC
authors.lastname: Preheim
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000382:microbiology; D002443:Ceftriaxone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007958:Leukocyte Count; D008081:Liposomes; D008297:Male; D009504:Neutrophils / Q000473:pathology; D011018:Pneumonia, Pneumococcal / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate
chemical_list: D008081:Liposomes; D002939:Ciprofloxacin; D002443:Ceftriaxone