Tumor-derived exosomes: a new source of tumor rejection antigens.
Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines.
André
F
F
Unite d'immunologie, Immunology Unit, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805 Villejuif Cedex, France. uimmunoc@igr.fr
Schartz
N E C
NE
Chaput
N
N
Flament
C
C
Raposo
G
G
Amigorena
S
S
Angevin
E
E
Zitvogel
L
L
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D006801:Humans; D051379:Mice
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines