title: Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity.
abstract: Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.
authors.affiliation: Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK. alexander.buerkle@uni-konstanz.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Bürkle
authors.forename: Sascha
authors.initials: S
authors.lastname: Beneke
authors.forename: Christine
authors.initials: C
authors.lastname: Brabeck
authors.forename: Alan
authors.initials: A
authors.lastname: Leake
authors.forename: Ralph
authors.initials: R
authors.lastname: Meyer
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Muiras
authors.forename: Ragen
authors.initials: R
authors.lastname: Pfeiffer
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D008136:Longevity / Q000235:genetics*; D008322:Mammals / Q000502:physiology*; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology*
chemical_list: D011065:Poly(ADP-ribose) Polymerases