title: [Development of severe lactic acidosis during radio frequency ablation conducted for the treatment of hepatocellular carcinomata in a patient with liver cirrhosis].
abstract: A 60-year-old male with liver cirrhosis (Child-Pugh class B) underwent laparotomic radio frequency ablation for the treatment of a solitary hepatocellular carcinoma (-4.5 cm in diameter). Severe lactic acidosis (base excess < -12 mEq.l-1, lactate > 150 mg.dl-1) developed during the intraoperative period, when neither his hemodynamics nor arterial oxygenation was significantly impaired. The blood loss was small (-200 g), and the serum hemoglobin level was maintained -10 g.dl-1 during the procedure. There was no evidence for impairment of either peripheral perfusion or renal function. In addition, there was no evidence for development of either splanchnic ischemia or diabetic ketoacidosis. Thus, the acidosis appeared to be caused by significant impairment of liver function possibly resulting from the ablation (total ablation time = -60 min). The core temperature increased rapidly (-1.5 degrees C/60 hr) immediately after the ablation was started, suggesting that a large amount of heat was produced in the ablated area and/or that the vicinity of the ablated area was richly supplied by blood flow. As a result, intact liver cells in the vicinity of the tumor probably suffered from thermal injuries. In conclusion, depending on preoperative liver function, ablated area, and/or blood flow in the vicinity of ablated area, the ablation may become significantly invasive.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka 812-8582.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shiokawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Akata
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshino
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kandabashi
authors.forename: Shosuke
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology*; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged