Human herpesvirus-7 infection of the CNS with acute myelitis in an adult bone marrow recipient.
The beta-herpesviruses, human herpesviruses-6 and -7 (HHV-6 and HHV-7), are closely related and have very similar biological behaviour. While HHV-6 is associated with encephalitis in immunosuppressed adults, HHV-7 is not recognised as a cause of neurological disease in such patients. This report describes the identification of a reactivated HHV-7 infection in the cerebrospinal fluid of an adult who presented with an acute myelitis 11 months after unrelated donor bone marrow transplant.
Ward
K N
KN
Department of Virology, Royal Free and University College Medical School, Windeyer Institute of Medical Sciences, London, UK.
White
R P
RP
Mackinnon
S
S
Hanna
M
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002555:Cerebrospinal Fluid / Q000821:virology; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D016199:Herpesvirus 7, Human / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D017710:Lymphocyte Transfusion; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000628:therapy; D009187:Myelitis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D020336:Paraparesis, Spastic / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D019349:Roseolovirus Infections / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects; D001750:Urinary Bladder, Neurogenic / Q000209:etiology; D014775:Virus Activation
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D008775:Methylprednisolone