title: [Retrospective epidemiological study on the durability of the treatment of HIV infection or AIDS in Spain].
abstract: OBJECTIVE
  To know the durability of consecutive regimens of antiretroviral treatment is important to design a long-term therapy, but there is not much information about this subject.
  
  
  METHODS
  Retrospective epidemiological study of a sample of 401 patients who began antiretroviral treatment between January 1997 and April 2000 at ten Spanish hospitals. The duration of each consecutive antiretroviral regimen was calculated and the reasons for modification and discontinuation were described.
  
  
  RESULTS
  In the 3 years and 3 months covered by the study, 48.6% of the patients received more than one regimen of therapy. Seventy five of the initial prescribed combinations included protease inhibitors. Median duration of consecutive lines of therapy was decreasing: 560, 360, 330 and 202 days for the first, second, third and fourth regimens, respectively. The main reason to modification was intolerance or toxicity (46.2, 49.1 and 47.1% for the first, second and third modification). A fifth of changes was originated by difficulties to follow the therapy. Virological failure was the reason for modification in 21.8, 24.5 and 26.5% of first, second and third changes.
  
  
  CONCLUSIONS
  Duration of consecutive antiretroviral regimens progressively decreases. Intolerance or drug toxicity were the main reasons conditioning the change of treatment.
authors.affiliation: Hospital la Paz. Madrid. España.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Arribas López
authors.forename: Susana
authors.initials: S
authors.lastname: Sanz Baena
authors.forename: Susana
authors.initials: S
authors.lastname: Hernández Albujar
authors.forename: Alicia
authors.initials: A
authors.lastname: Lorenzo Hernández
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Montes Ramiréz
authors.forename: Rosario
authors.initials: R
authors.lastname: Palacios Muñoz
authors.forename: Manuel
authors.initials: M
authors.lastname: Márquez Solero
authors.forename: Jesús
authors.initials: J
authors.lastname: Santos González
authors.forename: Antonio
authors.initials: A
authors.lastname: Ocampo Hermida
authors.forename: Celia
authors.initials: C
authors.lastname: Miralles Alvarez
authors.forename: José
authors.initials: J
authors.lastname: López Aldeguer
authors.forename: Miguel
authors.initials: M
authors.lastname: Salavert Lletí
authors.forename: Pablo
authors.initials: P
authors.lastname: Tordera Higón
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Santamaría Jáuregui
authors.forename: Ramón M
authors.initials: RM
authors.lastname: Teira Cobo
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno Guillén
authors.forename: Ana
authors.initials: A
authors.lastname: Moreno Zamora
authors.forename: José M
authors.initials: JM
authors.lastname: Gatell Artigas
authors.forename: José
authors.initials: J
authors.lastname: Mallotas Masferrer
authors.forename: Pilar
authors.initials: P
authors.lastname: Callau Cabrera
authors.forename: Miguel Torralba
authors.initials: MT
authors.lastname: Gonzáles de Suso
authors.forename: Asunción
authors.initials: A
authors.lastname: Costa Cerdá
authors.forename: Concepción
authors.initials: C
authors.lastname: Cepeda Gonzáles
authors.forename: Federico
authors.initials: F
authors.lastname: Pulido Ortega
authors.forename: Emilia
authors.initials: E
authors.lastname: Condes Moreno
authors.forename: Carlos
authors.initials: C
authors.lastname: Barros Aguado
authors.forename: Juan
authors.initials: J
authors.lastname: del Llano Señarís
authors.forename: Alicia
authors.initials: A
authors.lastname: Coduras
authors.forename: Juan
authors.initials: J
authors.lastname: Olivia
authors.forename: Angel
authors.initials: A
authors.lastname: Burgos Ramírez
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Beatriz
authors.initials: B
authors.lastname: Díaz
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents