title: Venous claudication in a child with thrombophilia.
abstract: Deep venous thrombosis (DVT) rarely occurs in active children. Its presence usually suggests an inherited or acquired hypercoagulable state. Occasionally mechanical obstruction may be the inciting factor in this process. Initial management usually consists of sequential heparin and warfarin anticoagulation. We present the management of DVT in an adolescent girl with elevated levels of C-reactive protein and lupus anticoagulant. Venous claudication and severe lower-extremity swelling on ambulation complicated her course. After more than 2 weeks of conservative therapy with anticoagulation thrombolytic therapy was instituted. This was terminated early because of mild hematuria. However, follow-up duplex scan at 2 years has shown complete resolution of the iliofemoral thrombosis. Spontaneous DVT in children differ from that in adults in that an underlying etiology can usually be uncovered. These differences are explored.
authors.affiliation: Department of Surgery, Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA.
authors.forename: Irwin M
authors.initials: IM
authors.lastname: Best
authors.forename: Harvey L
authors.initials: HL
authors.lastname: Bumpers
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D015912:Thrombolytic Therapy; D019851:Thrombophilia / Q000097:blood / Q000150:complications*; D020246:Venous Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D016682:Lupus Coagulation Inhibitor; D014859:Warfarin; D006493:Heparin; D002097:C-Reactive Protein