title: Measuring cardiac output during dobutamine infusion after off-pump coronary artery bypass: comparison of transesophageal echo-Doppler and thermodilution.
abstract: OBJECTIVE
  To compare transesophageal echo-Doppler with thermodilution method for measuring cardiac output during dobutamine infusion after off-pump coronary artery bypass.
  
  
  METHODS
  Using transesophageal echo-Doppler and thermodilution methods, we measured cardiac output in 30 patients after off-pump coronary artery bypass, immediately before and 5, 15, and 30 min after the introduction of continuous dobutamine infusion (3 microg/kg/min). Paired t-test and Bland-Altman analysis were used to compare the results obtained by two methods in this prospective study.
  
  
  RESULTS
  Significant increase in cardiac output during dobutamine infusion was detected by both thermodilution (from 3.9 +/- 1.0 to 4.6 +/- 1.1 L/min; p < 0.001) and transesophageal echo-Doppler (from 3.8 +/- 1.2 to 4.8 +/- 1.4 L/min; p < 0.001). Initial measurement results of thermodilution and transesophageal echo-Doppler techniques showed clinically acceptable agreement, with a mean difference of only + 0.09 L/min (95% confidence interval (CI), 0.42 to + 0.61). Subsequently repeated measurements after 5, 15, and 30 min showed almost the same agreement between the methods. The highest mean difference between the initial and repeated measurements was found at 5 min after the introduction of dobutamine infusion (-0.29 L/min, 95% CI, -1.06 to + 0.48).
  
  
  CONCLUSIONS
  Transesophageal echo-Doppler and thermodilution can be interchangeable as methods for measuring cardiac output after off-pump coronary artery bypass.
authors.affiliation: Department of Anesthesiology and Intensive Therapy, Dubrava University Hospital, Zagreb, Croatia. kka@kbd.hr
authors.forename: Ino
authors.initials: I
authors.lastname: Husedzinović
authors.forename: Stjepan
authors.initials: S
authors.lastname: Barisin
authors.forename: Dinko
authors.initials: D
authors.lastname: Tonković
authors.forename: Sinisa
authors.initials: S
authors.lastname: Sostarić
mesh_terms: D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000601:surgery*; D017523:Croatia; D004280:Dobutamine / Q000008:administration & dosage*; D017548:Echocardiography, Transesophageal; D005260:Female; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013815:Thermodilution
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine