title: A novel chiral ferrocenyl phosphine ligand from sugar: applications in Rh-catalyzed asymmetric hydrogenation reactions.
abstract: [structure: see text] A new chiral ferrocenyl diphosphine ligand 3 was synthesized from readily available D-mannitol. Rh-complex with this ligand showed high enantioselectivity and reactivity in the asymmetric hydrogenation of dehydroamino acid derivatives and itaconic acid derivatives. Up to over 99% ee and 10 000 TON were achieved with this catalytic system.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
authors.forename: Duan
authors.initials: D
authors.lastname: Liu
authors.forename: Wenge
authors.initials: W
authors.lastname: Li
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D008353:Mannitol / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D008024:Ligands; D010720:Phosphines; D008353:Mannitol; D012238:Rhodium