title: IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains.
abstract: IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr) is a high quality integrated information system specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) of human and other vertebrates. IMGT provides a common access to expertly annotated data on the genome, proteome, genetics and structure of the IG and TR, based on the IMGT Scientific chart and IMGT-ONTOLOGY. The IMGT unique numbering defined for the IG and TR variable regions and domains of all jawed vertebrates has allowed a redefinition of the limits of the framework (FR-IMGT) and complementarity determining regions (CDR-IMGT), leading, for the first time, to a standardized description of mutations, allelic polymorphisms, 2D representations (Colliers de Perles) and 3D structures, whatever the antigen receptor, the chain type, or the species. The IMGT numbering has been extended to the V-like domain and is, therefore, highly valuable for comparative analysis and evolution studies of proteins belonging to the IG superfamily.
authors.affiliation: IMGT, Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Université Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France. lefranc@ligm.igh.cnrs.fr
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Lefranc
authors.forename: Christelle
authors.initials: C
authors.lastname: Pommié
authors.forename: Manuel
authors.initials: M
authors.lastname: Ruiz
authors.forename: Véronique
authors.initials: V
authors.lastname: Giudicelli
authors.forename: Elodie
authors.initials: E
authors.lastname: Foulquier
authors.forename: Lisa
authors.initials: L
authors.lastname: Truong
authors.forename: Valérie
authors.initials: V
authors.lastname: Thouvenin-Contet
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefranc
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D022801:Complementarity Determining Regions / Q000235:genetics; D030541:Databases, Genetic; D016678:Genome; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D020543:Proteome / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000145:classification / Q000235:genetics*
chemical_list: D022801:Complementarity Determining Regions; D007136:Immunoglobulins; D020543:Proteome; D011948:Receptors, Antigen, T-Cell