Comparison of leuprolide acetate and triptorelin in assisted reproductive technology cycles: a prospective, randomized study.
OBJECTIVE
To compare the use of two depot GnRH-a, leuprolide and triptorelin, in long-suppression GnRH-a protocols.


METHODS
Prospective, randomized study.


METHODS
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.


METHODS
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle. Stimulation with gonadotropins was initiated after pituitary desensitization was achieved.


METHODS
The stimulation pattern and cycle outcomes were compared between the two groups.


RESULTS
Twenty-six patients were included in each group. No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred. However, significantly higher clinical implantation and pregnancy rates were found in the leuprolide group compared with the triptorelin group.


CONCLUSIONS
A depot preparation of leuprolide is associated with higher implantation and pregnancy rates than a depot preparation of triptorelin when it is used in the midluteal phase as part of the long-suppression GnRH-a protocol in IVF.
Orvieto
Raoul
R
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
Kerner
Ram
R
Krissi
Haim
H
Ashkenazi
Jacob
J
Ben Rafael
Zion
Z
Bar-Hava
Itai
I
D000328:Adult; D003692:Delayed-Action Preparations; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D005300:Fertility Agents, Female; D017329:Triptorelin Pamoate; D016729:Leuprolide