title: Prognostic effects of local recurrence after conservative treatment for early infiltrating breast carcinoma.
abstract: OBJECTIVE
  A study was carried out to determine whether local recurrence after quadrantectomy, axillary dissection and radiotherapy (QUART) affects the oncologic prognosis of patients with early infiltrating breast carcinoma.
  
  
  METHODS
  A total of 149 patients were submitted to QUART between 1981 and 1990 and followed by an average period of 120.9 months (range, 16-213). Local recurrence was not observed in 132 cases (group 1) but was detected in 17 patients (group 2).
  
  
  RESULTS
  In group 1, 39 cases (29.5%) presented distant metastases and 34 (25.8%) evolved to death. In group 2, 10 (51.8%) distant metastases and 9 deaths (52.9%) were verified. The survival curves estimated by the Kaplan-Meier method and analyzed by the logrank test were statistically different for distant metastases-free survival (P = 0.03) and for overall survival (P = 0.01). The relative risk in patients with post-QUART local recurrence for distant metastases was 2.09 and for death 2.34.
  
  
  CONCLUSIONS
  It was concluded that post-QUART local recurrences are a poor prognostic factor in patients with early infiltrating breast carcinoma.
authors.affiliation: Gynecologic Clinic of University of São Paulo Medical School, São Paulo, Brazil. acbarros.ops@terra.com.br
authors.forename: Alfredo Carlos S D
authors.initials: AC
authors.lastname: Barros
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Teixeira
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Nisida
authors.forename: Marianne
authors.initials: M
authors.lastname: Pinotti
authors.forename: Jose Aristodemo
authors.initials: JA
authors.lastname: Pinotti
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis