Extracellular ATP induces phosphatidylserine externalization earlier than nuclear apoptotic events in thymocytes.
The present study shows for the first time that ATP(ec) induces a very early PS exposure in thymocytes and that this process can be induced in the absence of Ca(2+) influx and caspase activation.
Courageot
Marie-Pierre
MP
Biomembranes et Messagers Cellulaires, CNRS-UMR 8619, Université Paris XI, 91405 Orsay Cedex, France.
Lepine
Sandrine
S
Giraud
Francoise
F
Sulpice
Jean-Claude
JC
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure; D002478:Cells, Cultured; D005110:Extracellular Space / Q000502:physiology; D051379:Mice; D010718:Phosphatidylserines / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000502:physiology
D010718:Phosphatidylserines; D000255:Adenosine Triphosphate; D002118:Calcium