Exposure of human skin diploid fibroblasts to repeated subcytotoxic doses of ultraviolet-B induces the overexpression of transforming growth factor-beta1 mRNA.
In this work we show that the steady state mRNA level of TGF-beta1 is significantly increased in UVB-induced premature senescence.
Chainiaux
Florence
F
Laboratory of Cellular Biochemistry and Biology, Department of Biology, University of Namur (FUNDP), Namur, Belgium.
Remacle
Jose
J
Toussaint
Olivier
O
D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000528:radiation effects; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000528:radiation effects*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000235:genetics*; D053773:Transforming Growth Factor beta1; D014466:Ultraviolet Rays
D012333:RNA, Messenger; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1