title: [Angiotensin-converting enzyme gene polymorphism in patients with primary disturbances of cardiac conduction].
abstract: Increased frequencies of angiotensin-converting enzyme (ACE) D-allele and ID-genotype among patients with idiopathic atrioventricular blocks and I allele and II genotype among patients with idiopathic intraventricular blocks allow to consider these genotypes risk factors of corresponding disturbances of cardiac conduction. Decreased frequency of ACE I allele and II genotype among patients with idiopathic atrioventricular blocks is indicative of a possible protective role of II genotype against development of this type of cardiac conduction defect. Low frequency of D allele and genotype D prevents derangements of conduction in His-Purkinje system.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Nikulina
authors.forename: V A
authors.initials: VA
authors.lastname: Shul'man
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Vorotnikova
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: T V
authors.initials: TV
authors.lastname: Kosiankova
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D015870:Gene Expression; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012083:Renin