title: Gammadelta T lymphocytosis associated with granulomatous disease in a patient with common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of immunodeficiency syndromes that involves defective production of specific antibodies and decreased serum concentrations of > or =1 immunoglobulin isotype. We describe a patient with an atypical case of CVID who had extensive granulomatous lesions that were partially attributable to mycobacterial infection. In the peripheral blood, there was a massive increase in the number of double-negative CD3+ T cells that expressed the gammadelta T cell receptor.
authors.affiliation: Clinique de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévêque, Centre François-Magendie, 33604 Pessac, France. jean-francois.viallard@chu-bordeaux.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Viallard
authors.forename: Coralie
authors.initials: C
authors.lastname: Bloch-Michel
authors.forename: Olivier
authors.initials: O
authors.lastname: Caubet
authors.forename: Marie
authors.initials: M
authors.lastname: Parrens
authors.forename: Jeannette
authors.initials: J
authors.lastname: Texier-Maugein
authors.forename: Martine
authors.initials: M
authors.lastname: Neau-Cransac
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Taupin
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Moreau
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pellegrin
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D008218:Lymphocytosis / Q000150:complications* / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D017252:CD3 Complex; D016692:Receptors, Antigen, T-Cell, gamma-delta