[Study on the relationship of balanced translocation t(1;12) with spermatogenesis].
OBJECTIVE
To investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers.


METHODS
For twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis.


RESULTS
Chromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis.


CONCLUSIONS
Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis.
Zhou
Zuo-Min
ZM
Department of Histology and Embryology, Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Liu
Jia-Yin
JY
Xu
Min
M
Sha
Jia-Hao
JH
Lin
Min
M
Zhou
Ya-Dong
YD
Wang
Li-Rong
LR
Li
Jian-Min
JM
D000328:Adult; D001706:Biopsy; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D004200:Diseases in Twins / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*