title: IL-28, IL-29 and their class II cytokine receptor IL-28R.
abstract: Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.
authors.affiliation: ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, WA 98102, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Sheppard
authors.forename: Wayne
authors.initials: W
authors.lastname: Kindsvogel
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Xu
authors.forename: Katherine
authors.initials: K
authors.lastname: Henderson
authors.forename: Stacy
authors.initials: S
authors.lastname: Schlutsmeyer
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Whitmore
authors.forename: Rolf
authors.initials: R
authors.lastname: Kuestner
authors.forename: Ursula
authors.initials: U
authors.lastname: Garrigues
authors.forename: Carl
authors.initials: C
authors.lastname: Birks
authors.forename: Jenny
authors.initials: J
authors.lastname: Roraback
authors.forename: Craig
authors.initials: C
authors.lastname: Ostrander
authors.forename: Dennis
authors.initials: D
authors.lastname: Dong
authors.forename: Jinu
authors.initials: J
authors.lastname: Shin
authors.forename: Scott
authors.initials: S
authors.lastname: Presnell
authors.forename: Brian
authors.initials: B
authors.lastname: Fox
authors.forename: Betty
authors.initials: B
authors.lastname: Haldeman
authors.forename: Emily
authors.initials: E
authors.lastname: Cooper
authors.forename: David
authors.initials: D
authors.lastname: Taft
authors.forename: Teresa
authors.initials: T
authors.lastname: Gilbert
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Grant
authors.forename: Monica
authors.initials: M
authors.lastname: Tackett
authors.forename: William
authors.initials: W
authors.lastname: Krivan
authors.forename: Gary
authors.initials: G
authors.lastname: McKnight
authors.forename: Chris
authors.initials: C
authors.lastname: Clegg
authors.forename: Don
authors.initials: D
authors.lastname: Foster
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Klucher
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D003001:Cloning, Molecular; D016207:Cytokines; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D021122:Protein Subunits; D012313:RNA / Q000235:genetics / Q000378:metabolism; D018121:Receptors, Cytokine / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology; D000095022:Interferon Lambda
chemical_list: D016207:Cytokines; D007372:Interferons; D007378:Interleukins; D021122:Protein Subunits; D012313:RNA; D018121:Receptors, Cytokine; D011994:Recombinant Proteins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C471046:interleukin 28alpha receptor