Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva.
Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC 50 values below 1 ng/ml.
Zhang
Hong-Jie
HJ
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, the University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Tamez
Pamela A
PA
Aydogmus
Zeynep
Z
Tan
Ghee Teng
GT
Saikawa
Yoko
Y
Hashimoto
Kimiko
K
Nakata
Masaya
M
Hung
Nguyen Van
NV
Xuan
Le Thi
le T
Cuong
Nguyen Manh
NM
Soejarto
D Doel
DD
Pezzuto
John M
JM
Fong
Harry H S
HH
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D029064:Araceae; D030681:Ficus; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000962:Antimalarials; D010936:Plant Extracts; D014255:Trichothecenes; C472149:satratoxin H 12',13'-diacetate; C472148:satratoxin H 13'-acetate; C472147:verrucarin L acetate; C014184:satratoxin H; C003797:roridin E