title: Prevalence of human papillomavirus infection in women in Busan, South Korea.
abstract: To investigate the prevalence of and the risk factors for human papillomavirus (HPV) infection in South Korea, we interviewed and examined a randomly selected sample of 863 sexually active women (age range = 20-74 years, median 44) and 103 self-reported virgins from Busan. The presence of DNA of 34 different HPV types in cervical exfoliated cells was tested among sexually active women by means of a PCR-based assay. IgG antibodies against L1 virus-like particles (anti-VLPs) of HPV types 16, 18, 31, 33 and 58 were also evaluated by means of ELISA. The overall prevalence of HPV DNA was 10.4% (95% confidence interval, CI: 8.5-12.7%). The most often found HPV DNA types were HPV 70, HPV 16 and HPV 33; 19.8% (95% CI: 17.2-22.0) of sexually active women had antibodies against one or more HPV types. The most common anti-VLPs were against HPV 18, 31 and 16. Prevalences standardized by age on the basis of the world standard population were 13.0% for HPV DNA and 17.1% for anti-VLPs. The concordance between the 2 HPV markers at an individual level was modest, but the risk factors for detection of HPV DNA and anti-VLPs were similar: number of lifetime sexual partners (odds ratio, OR for >/= 4 vs. 1 = 3.5 and 5.4, respectively), seropositivity for herpes simplex virus-2 antibodies (OR = 2.6 and 2.5, respectively) and being single or divorced. HPV DNA, but not anti-VLPs, were elevated among women whose husbands were thought by their wives to have extra-marital affairs and those who had undergone vasectomy. Among 103 virgins, 4.9% had anti-VLPs (1/73 among those aged 24 years or less).
authors.affiliation: Division of Cancer Epidemiology and Control, National Cancer Center Research Institute, Goyang, Korea.
authors.forename: Hai-Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Duk-Hee
authors.initials: DH
authors.lastname: Lee
authors.forename: Rolando
authors.initials: R
authors.lastname: Herrero
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: Salvatore
authors.initials: S
authors.lastname: Vaccarella
authors.forename: Sook-Hee
authors.initials: SH
authors.lastname: Hong
authors.forename: Kap-Yeol
authors.initials: KY
authors.lastname: Jung
authors.forename: Hyun-Ho
authors.initials: HH
authors.lastname: Kim
authors.forename: Un-Dong
authors.initials: UD
authors.lastname: Park
authors.forename: Hyung-Su
authors.initials: HS
authors.lastname: Cha
authors.forename: Soyoon
authors.initials: S
authors.lastname: Park
authors.forename: Antoine
authors.initials: A
authors.lastname: Touzé
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
authors.forename: Peter J F
authors.initials: PJ
authors.lastname: Snijders
authors.forename: Chris J L M
authors.initials: CJ
authors.lastname: Meijer
authors.forename: Pierre
authors.initials: P
authors.lastname: Coursaget
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral