title: SPPS of protected peptidyl aminoalkyl amides.
abstract: Monophthaloyl diamines derived from naturally occurring amino acids were attached through their free amino functions to resins of the trityl type. The phthaloyl groups were removed by hydrazinolysis, and peptide chains were assembled using Fmoc/tBu-amino acids on the liberated amino functions. The peptidyl aminoalkyl amides obtained were cleaved from the resins by mild acidolysis, with the tBu-side chain protection remaining intact.
authors.affiliation: Department of Chemistry, University of Patras, Patras, Greece.
authors.forename: Manolis
authors.initials: M
authors.lastname: Karavoltsos
authors.forename: Spyros
authors.initials: S
authors.lastname: Mourtas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gatos
authors.forename: Kleomenis
authors.initials: K
authors.lastname: Barlos
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000577:Amides; D010455:Peptides