[Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin].
Aerosol delivery of antibiotics offers the potential to achieve high antibiotic concentrations at the site of infection while reducing the risk of systemic untoward effects because of minimal resorption into the bloodstream. We reviewed knowledge acquired in this field over the two latter decades. While the earliest data were obtained with gentamycin, the most conclusive evidence presently regards aminoglycosides and colistin. Aerosol delivery of tobramycin was recently improved with the development of a new formulation for inhalation. Coupled with an adequate nebulization system, intermittent treatment with tobramycin for inhalation has been evaluated in randomized placebo-controlled studies. These studies have demonstrated a significant improvement of respiratory function.
Foucaud
P
P
Service de Pédiatrie, Hôpital André-Mignot, Centre Hospitalier de Versailles, 78157 Le Chesnay. pfoucaud@ch-versailles.fr
Borel
B
B
Charara
O
O
Nathanson
S
S
Petitprez
P
P
Pin
I
I
D000280:Administration, Inhalation; D000293:Adolescent; D000336:Aerosols; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002228:Carbenicillin / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D009330:Nebulizers and Vaporizers; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D010919:Placebos; D011113:Polymyxins / Q000008:administration & dosage / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage*
D000336:Aerosols; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D010919:Placebos; D011113:Polymyxins; D002228:Carbenicillin; D014031:Tobramycin; D003091:Colistin