title: Validation of the Hong Kong Chinese version of the St. George Respiratory Questionnaire in patients with bronchiectasis.
abstract: OBJECTIVE
  To validate the Hong Kong Chinese version of the St. George Respiratory Questionnaire (SGRQ-HK) in patients with bronchiectasis.
  
  
  METHODS
  Outpatients (93 patients; 61 women; mean age [+/- SD], 59.0 +/- 14.2 years) were assessed at baseline by the SGRQ-HK, the Hong Kong Chinese version of the 36-item short form health survey (SF-36-HK), and the hospital anxiety and depression scale (HADS). Forty randomly selected patients also were reassessed at 2 weeks for repeatability. Seventy-two patients were further reassessed at 6 months for responsiveness.
  
  
  RESULTS
  Cronbach alpha coefficients, which reflected internal consistency, were > 0.7 for all SGRQ-HK components except for symptoms (alpha = 0.59), and the intraclass correlation coefficients between baseline and the 2-week follow-up visits were between 0.80 and 0.94 (p > 0.05). SGRQ-HK component scores and total scores correlated with all the component scores of the SF-36-HK and the HADS (p < 0.02). SGRQ-HK component scores and total scores correlated with the scores of the SF-36-HK and the HADS, confirming the concurrent validity. All SGRQ-HK scores correlated negatively with FEV(1), FVC, and arterial oxygen saturation (p < 0.005), while the activity score correlated with the Karnofsky performance scale and the number of bronchiectatic lobes (p < 0.001). SGRQ-HK scores positively correlated with Borg scale scores, exacerbation frequency, and 24-h sputum volumes (p < 0.03). Patients with 24-h sputum volumes of > or = 10 mL or < 10 mL had significantly different SQRG-HK component scores and total scores (p < 0.002), although this sensitivity was not displayed by scores on the HADS or the SF-36-HK. Patients with 25% reductions in 24-h sputum volumes had significant improvements in SGRQ-HK activity scores, impact scores, and total scores (p < 0.02), but not in other quality-of-life measures or clinical parameters, indicating the responsiveness of the SGRQ-HK.
  
  
  CONCLUSIONS
  The SGRQ-HK is a valid and sensitive instrument for determining quality of life in bronchiectasis patients.
authors.affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region.
authors.forename: Shelley L
authors.initials: SL
authors.lastname: Chan
authors.forename: Moira M
authors.initials: MM
authors.lastname: Chan-Yeung
authors.forename: Gaik C
authors.initials: GC
authors.lastname: Ooi
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Lam
authors.forename: Tung F
authors.initials: TF
authors.lastname: Cheung
authors.forename: Wah K
authors.initials: WK
authors.lastname: Lam
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Tsang
mesh_terms: D001987:Bronchiectasis / Q000503:physiopathology*; D002681:China / Q000208:ethnology; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012143:Respiratory Physiological Phenomena; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000592:standards*