Unsymmetrical diaryl sulfones through palladium-catalyzed coupling of aryl iodides and arenesulfinates.
[reaction: see text] The palladium-catalyzed coupling of aryl iodides and arenesulfinates provides a simple and extremely efficient new route to unsymmetrical diaryl sulfones, usually isolated in high yield. The reaction tolerates a variety of functionalized aryl iodides, including those containing ether, ester, and nitro groups. The best results have been obtained by using Pd(2)(dba)(3), Xantphos, Cs(2)CO(3), and (n)Bu(4)NCl in toluene at 80 degrees C.
Cacchi
Sandro
S
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi La Sapienza, P. le A. Moro 5, 00185 Rome, Italy. sandro.cacchi@uniroma1.it
Fabrizi
Giancarlo
G
Goggiamani
Antonella
A
Parisi
Luca M
LM
D019380:Anti-HIV Agents / Q000138:chemical synthesis; D001190:Arylsulfonates / Q000138:chemical synthesis*; D002384:Catalysis; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D007462:Iodobenzenes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D001190:Arylsulfonates; D007462:Iodobenzenes; D013450:Sulfones; D010165:Palladium; D054303:HIV Reverse Transcriptase