Dissociation of human thalamic and cortical SEP gating as revealed by intrathalamic recordings under muscle relaxation.
'Gating' refers to a reduction of cortical somatosensory evoked potentials (SEP) under multiple simultaneous afferent inputs. This study used the opportunity for intrathalamic recordings in patients with movement disorders to clarify to what extent cortical SEP gating is preceded by thalamic gating. Recordings were performed in 10 patients, narcotised by intravenous propofol when receiving implantation of a therapeutic deep brain stimulator system. SEP were elicited by an 8.1-Hz median nerve stimulation at twice motor threshold and were recorded simultaneously from both intrathalamic and scalp electrodes before and after the application of the depolarising muscle blocker succinylcholine which eliminated both the background muscular tone and the repetitive muscle twitches caused by the median nerve stimulation. Peripheral compound action potentials recorded at the upper arm remained unchanged after complete muscle relaxation, proving a continuously effective nerve stimulation. In contrast, the primary cortical SEP component (N20) was significantly increased under succinylcholine (+17%). This cortical release from gating was not paralleled, however, by an increased thalamic response; rather, the primary thalamic response (P16) showed a slight (-9%) but highly significant amplitude reduction. As the recordings were performed in narcotised patients, any potentially variable attentional bias on part of the subjects can be excluded as confounding factor when comparing the two experimental conditions with vs. without reafferent somatosensory inflow. Thus, given the high signal-to-noise ratio of intrathalamically recorded SEP, the present study shows a distinct thalamo-cortical dissociation with the primary somatosensory cortex representing the predominant level exhibiting SEP gating.
Klostermann
Fabian
F
Neurophysics Group, Department of Neurology, Universitätsklinikum Benjamin Franklin, Freie Universitaet, Berlin, Germany. fkloster@zedat.fu-berlin.de
Gobbele
René
R
Buchner
Helmut
H
Curio
Gabriel
G
D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology*; D000368:Aged; D004599:Electric Stimulation Therapy; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D008875:Middle Aged; D009069:Movement Disorders / Q000628:therapy; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D013390:Succinylcholine / Q000494:pharmacology; D020651:Ventral Thalamic Nuclei / Q000502:physiology*
D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine