Preparation of [11C] radioligands with high specific radioactivity on a commercial PET tracer synthesizer.
High specific radioactivity is required for receptor studies with PET. Hereby we wish to report our experience using Nuclear Interface PET Tracer Synthesizer for preparation of Carbon-11 radioligands and module's modifications, which allowed to achieve high specific radioactivity.
Matarrese
Mario
M
IBFH-CNR, University of Milano/Bicocca, Institute H San Raffaele, Milano, Italy.
Soloviev
Dmitri
D
Todde
Sergio
S
Neutro
Felice
F
Petta
Pasquale
P
Carpinelli
Assunta
A
Brüssermann
Michael
M
Galli Kienle
Marzia
M
Fazio
Ferruccio
F
D002245:Carbon Dioxide / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D004867:Equipment Design; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods*; D008024:Ligands; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*
D002250:Carbon Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; D002245:Carbon Dioxide