Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands.
OBJECTIVE
To estimate the cost-effectiveness of the current screening programme on Familial Hypercholesterolaemia (FH) in relatives of diagnosed FH-patients in The Netherlands.


RESULTS
Data from 2229 screened FH-relatives, including age, sex, risk factor status and screening outcome, were combined with the Framingham risk function and national disease-specific cost data to arrive at a model-based comparison of survival and costs, with and without the screening programme. Cost-effectiveness ratios were computed for various treatment strategies, with no screening as reference. Costs per life year gained varied between 25.5- and 32-thousand Euros, depending upon the precise treatment strategy after a positive screen. The costs for screening (tracing the FH-positive individuals) were much lower than the follow-up costs (treatment), of which 80% were costs for statins. Consequently, the costs per life year gained of alternative screening programmes are about the same.


CONCLUSIONS
The cost-effectiveness ratio of FH screening is within the range requiring explicit political consideration in The Netherlands. As the costs of statin treatment are the single most important determinant of costs, policy decisions reduce to decisions on the acceptability of statin treatment for this risk group. Pending major changes in statin price, clear guidelines should be developed on how screen positive individuals should be treated, since not all of them have an elevated cholesterol level.
Marang-van de Mheen
P J
PJ
Department of Social Medicine, Academic Medical Center, Amsterdam, The Netherlands.
ten Asbroek
A H A
AH
Bonneux
L
L
Bonsel
G J
GJ
Klazinga
N S
NS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003327:Coronary Disease / Q000175:diagnosis / Q000191:economics / Q000235:genetics; D003362:Cost-Benefit Analysis; D005820:Genetic Testing / Q000191:economics*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis* / Q000191:economics / Q000235:genetics; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D009426:Netherlands; D015397:Program Evaluation; D012307:Risk Factors; D012680:Sensitivity and Specificity
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors