Gender impact on first trimester markers in Down syndrome screening.
The influence of fetal gender on the level in the first trimester of the serological markers alpha-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (betahCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free betahCG, being 16% higher for female than for male fetuses.
Larsen
Severin Olesen
SO
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark. sol@ssi.dk
Wøjdemann
Karen R
KR
Shalmi
Anne-Cathrine
AC
Sundberg
Karin
K
Christiansen
Michael
M
Tabor
Ann
A
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003718:Denmark / Q000453:epidemiology; D004314:Down Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D009333:Neck / Q000000981:diagnostic imaging / Q000196:embryology; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D012727:Sex Characteristics; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D011266:Pregnancy-Associated Plasma Protein-A