title: [Contraception and neurology].
abstract: The purpose of this article is to clarify interactions between oral contraception (using low- and high-dose oral contraceptives) and the main neurological diseases occurring in genitally active women. Vascular disorders predominate, since contraception is in itself a well-recognized a risk factor, especially in case of other intercurrent risk factors (high blood pressure, smoking, diabetes, history of vascular event) contradicting contraception. Low-dose oral contraception can be proposed for women free of these risk factors. There is however a formal contraindication for oral contraception, even with mini-dose contraceptives, for women with a history of cerebral venous thrombosis. In case of migraine headache, which is also a risk factor of vascular disease (especially in case of aura), oral contraceptives should be discussed on an individual basis, depending on the presence of other risk factors. Contraception has no effect on epilepsy but oral contraceptives may be inhibited by inducing anti-seizure drugs. Non-inducing drugs are preferable. The course of certain brain tumors known to express estrogen or progesterone receptors (particularly meningiomas and hemangioblastomas) may worsen with oral contraception, which is formally contradicted except when search for hormone receptors is negative. Oral contraception has no influence in other disease such as multiple sclerosis
authors.affiliation: Service de Neurochirurgie, Hôpital Beaujon, 100, boulevard Général-Leclerc, 92118 Clichy Cedex, France. caroline.combes@bjn.ap-hop-paris.fr
authors.forename: Caroline
authors.initials: C
authors.lastname: Combes
authors.forename: Aimée
authors.initials: A
authors.lastname: Redondo
authors.forename: Alain
authors.initials: A
authors.lastname: Rey
mesh_terms: D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000473:pathology; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage; D000075202:Contraindications; D004357:Drug Synergism; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D018325:Hemangioblastoma / Q000737:chemistry; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced*; D008579:Meningioma / Q000737:chemistry; D008881:Migraine Disorders / Q000139:chemically induced* / Q000503:physiopathology; D011960:Receptors, Estrogen / Q000032:analysis; D012307:Risk Factors; D012598:Sclerosis; D014664:Vasodilation
chemical_list: D000927:Anticonvulsants; D003278:Contraceptives, Oral, Hormonal; D011960:Receptors, Estrogen