title: Pleomorphic adenoma of the submandibular gland: clinicopathological and immunohistochemical features of 60 cases in Brazil.
abstract: The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were women. Tumor sizes varied from 1 to 10 cm and the mean time between symptom onset and treatment was 52 months. Only 1 patient experienced local recurrence, 3 years after treatment. Histologically, most tumors consisted chiefly in a chondromyxoid stroma. Stroma-rich PAs were larger than stroma-poor ones (P<.02). All PAs were found negative for Ki-67 and p53. These results show that PAs of the submandibular gland are histologically similar to PAs of other salivary glands, and that they have a low proliferative rate and a good prognosis.
authors.affiliation: Hospital do Câncer-Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, R. Prof. Antônio Prudente, 211, CEP 01509-900, São Paulo, Brazil.
authors.forename: Fàbio A
authors.initials: FA
authors.lastname: Alves
authors.forename: Daniel E C
authors.initials: DE
authors.lastname: Perez
authors.forename: Osley P
authors.initials: OP
authors.lastname: Almeida
authors.forename: Márcio A
authors.initials: MA
authors.lastname: Lopes
authors.forename: Luiz P
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53