title: Newborn screening: rationale for a comprehensive, fully integrated public health system.
abstract: Newborn screening has existed for approximately four decades. During that period of time, newborn screening has evolved conceptually from a laboratory test for a single disorder, phenylketonuria (PKU), to a multi-part public health system involving education, screening, diagnostic follow-up, treatment/management, and system evaluation. At a time when newborn screening is recognized as a model for predictive medicine, it also faces critical challenges that will determine its future credibility and viability. In order to understand these challenges, it is helpful to review briefly the history of newborn screening.
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1752, USA.
authors.forename: Linda L
authors.initials: LL
authors.lastname: McCabe
authors.forename: Bradford L
authors.initials: BL
authors.lastname: Therrell
authors.forename: Edward R B
authors.initials: ER
authors.lastname: McCabe
mesh_terms: D005544:Forecasting; D005820:Genetic Testing / Q000639:trends; D006801:Humans; D007231:Infant, Newborn; D011159:Population Surveillance; D015980:Public Health Practice