[Clinical and experimental study of treatment of nanmiqing capsule for chronic prostatitis].
OBJECTIVE
To investigate the clinical effect and therapeutic mechanism of Nanmiqing capsule made of rheum palmatum, leech, astragalus memberanaceus on patients with chronic prostatitis(CP).


METHODS
Seventy-six CP cases were treated with Nanmiqing, while 32 CP cases were treated with Qianliekang as a control. The changes of EPS were observed pre- and post-treatment. The rat model of CP got by Xiaozhiling inducing were treated with Nanmiqing and Qianliekang respectively. The concentration of endothelin, TXB2, 6-keto-PGF1 alpha and SOD, IgG, IgA in plasma were measured pre- and post-treatment, meanwhile, pathological changes of prostate tissues were observed.


RESULTS
The total effective rate was 89.47% in treatment group, which was significantly higher than 71.88% in the control group (P < 0.01). Experimental study for CP rats showed that the Nanmiqing was more effective medicine than Qianliekang (P < 0.01).


CONCLUSIONS
Nanmiqing was an effective medicine for CP. The mechanism of clearing heat and resolving toxin, activating blood and removing stasis and reinforcing Qi in chinese medicine could be the explanation of the useful treatment including three therapentic ways.
Dai
Chun-Fu
CF
Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian 350003, China.
Zhang
Zhi-Zhong
ZZ
Qi
Xing-Liang
XL
Zhang
Ming-Xuan
MX
Li
Yan-Ping
YP
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D002214:Capsules; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism; D016896:Treatment Outcome
D002214:Capsules; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D007070:Immunoglobulin A; D007074:Immunoglobulin G; C469994:nanmiqing; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013482:Superoxide Dismutase