[Relation between the expression of P-gp and GST-pi in oral and maxillofacial squamous carcinoma and chemoresistance].
OBJECTIVE
To investigating the relation between the expression of P-glycoprotein and Glutathione transferase-pi and the chemoresistance.


METHODS
The expressions of these two proteins in patients with oral and maxillofacial squamous carcinoma and normal oral tissues were detected by immunohistochemistry.


RESULTS
The positive expression rate of P-gp and GST-pi in oral and maxillofacial malignant tumor was 57.1% and 53.6% respectively, and no expression in normal oral tissues; the expression of GST-pi was relevant to the resistance to cisplatin, while the expression of P-gp was relevant to the resistance to chemotherapeutic drug in general.


CONCLUSIONS
The method of immunohistochemistry combining MTT assay in vitro may become an efficient way to predict the sensitivity to chemotherapeutic drug.
Xu
Qing
Q
Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Lin
Guochu
G
Chen
Wantao
W
Zhou
Xiaojian
X
Lin
Lisong
L
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D005153:Facial Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D005562:Formazans; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis*; D008441:Maxillary Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D009062:Mouth Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D013778:Tetrazolium Salts
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005562:Formazans; D007527:Isoenzymes; D013778:Tetrazolium Salts; C079782:MTT formazan; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase