title: Auto-immune neutropenia occurring in association with malignant melanoma.
abstract: Neutropenia is frequently observed in the practice of oncology, usually resulting from the use of cytotoxic drugs. Less frequently, neutropenia is due to infiltration of the bone marrow by malignant disease. Both of these usually cause some depletion of all haematopoietic linages. True isolated neutropenia is, in contrast, a less frequent phenomenon. We report a case of auto-immune neutropenia occurring in a patient with metastatic melanoma, and discuss the differential diagnosis and implications for patient management.
authors.affiliation: Cancer Research UK Department of Medical Oncology, Beatson Oncology Centre, Western Infirmary, Glasgow, G11 6NT, UK. white.jeff@talk21.com
authors.forename: J D
authors.initials: JD
authors.lastname: White
authors.forename: I R J
authors.initials: IR
authors.lastname: MacPherson
authors.forename: T R J
authors.initials: TR
authors.lastname: Evans
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D009503:Neutropenia / Q000175:diagnosis / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology*
chemical_list: D000970:Antineoplastic Agents