Labetalol for prophylactic treatment of intractable migraine during pregnancy.
Headaches tend to improve in the majority of migraineurs during pregnancy, but some patients report a worsening of migraine and present a management challenge because of the restrictions of pharmacotherapy during pregnancy. Treatment options become even more limited for pregnant migraineurs who develop preeclampsia. Labetalol was tried successfully in reducing the frequency, duration, and intensity of migraine attacks in a pregnant woman with preeclampsia. There were no significant side effects and the patient delivered a healthy baby without complications.
Dey
Ranjan
R
Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.
Khan
Sajid
S
Akhouri
Vimal
V
Wootton
Joshua
J
Bajwa
Zahid H
ZH
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007741:Labetalol / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000150:complications / Q000517:prevention & control*; D010148:Intractable Pain / Q000150:complications / Q000188:drug therapy*; D011225:Pre-Eclampsia / Q000150:complications / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D007741:Labetalol