title: Variations in MLL amplification in a patient with acute myeloid leukemia.
abstract: In a 66 years old female patient with acute myeloblastic leukemia (AML) complex chromosomal rearrangements involving 11q23 were diagnosed by G-banding and confirmed by different fluorescence in situ hybridization (FISH) techniques. The amplification of MLL gene differed in various sidelines as shown by locus specific probes for 11q23 and 11q13. Complex karyotype rearrangements involving deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in situ hybridization (mFISH).
authors.affiliation: Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic. brez@uhkt.cz
authors.forename: Jana
authors.initials: J
authors.lastname: Brezinová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zemanová
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Cermák
authors.forename: Sárka
authors.initials: S
authors.lastname: Kurková
authors.forename: Lenka
authors.initials: L
authors.lastname: Sindelárová
authors.forename: Jirí
authors.initials: J
authors.lastname: Schwarz
authors.forename: Kyra
authors.initials: K
authors.lastname: Michalová
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005784:Gene Amplification / Q000502:physiology*; D015321:Gene Rearrangement; D014644:Genetic Variation; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase