title: Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a review.
abstract: This paper reviews the current applications of diffusion-weighted and diffusion tensor MRI in diseases of the brain white matter. The contribution that diffusion-weighted imaging has made to our understanding of white matter diseases is critically appraised. The quantitative nature of diffusion MRI is one of its major attractions; however, this is offset by the more advanced hardware required to collect diffusion-weighted images reliably, and the more complex processing to produce quantitative parametric diffusion images. With the now common availability of scanners equipped to perform echo-planar imaging, the acquisition of diffusion tensor images is sure to become more widespread and routine.
authors.affiliation: Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, UK. mah5@le.ac.uk
authors.forename: Mark A
authors.initials: MA
authors.lastname: Horsfield
authors.forename: Derek K
authors.initials: DK
authors.lastname: Jones
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology; D016880:Anisotropy; D001921:Brain / Q000378:metabolism / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism / Q000473:pathology; D015161:Dementia, Multi-Infarct / Q000378:metabolism / Q000473:pathology; D003711:Demyelinating Diseases / Q000378:metabolism* / Q000473:pathology*; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D015658:HIV Infections / Q000378:metabolism / Q000473:pathology; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology; D009434:Neural Pathways / Q000378:metabolism* / Q000473:pathology*; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water