title: Value of automated segmental motion analysis in the assessment of aortic stenosis severity.
abstract: OBJECTIVE
  Left ventricular (LV) contraction is slowed in patients with aortic stenosis (AS). Although the possible role of LV systolic function abnormalities in the assessment of AS severity has been evaluated, current echocardiographic techniques cannot offer precise quantification of LV motion velocity. The study aim was to evaluate an automated segmental motion analysis (ASMA) system to assess AS severity.
  
  
  METHODS
  Twenty-two patients with AS, sinus rhythm and preserved LV ejection fraction were studied prospectively. Patients underwent both conventional Doppler echocardiography to measure transaortic gradient and aortic valve area by the continuity equation, and ASMA of the interventricular septum. The ASMA line graph mode displays changes in area through the cardiac cycle. The RR interval and time from the R-wave to peak maximum area shortening were measured, and an ASMA index was calculated.
  
  
  RESULTS
  A significant and strong inverse correlation was found between aortic valve area and ASMA index (r = -0.78; 95% CI -0.90 to -0.55; p <0.001). The area under the ROC curve in the diagnosis of severe AS (aortic valve area < or =0.8 cm2) was 0.97 (95% CI 0.90-1.0). Sensitivity, specificity, positive and negative predictive values and overall accuracy for an ASMA index >0.40 were 100, 91.7, 92.3, 100 and 95.8%, respectively.
  
  
  CONCLUSIONS
  The ASMA system may be valuable in evaluating AS, as it offers a strong correlation with aortic valve area calculated by the continuity equation, and very high sensitivity and specificity in the diagnosis of severe AS.
authors.affiliation: Laboratory of Echocardiography, Instituto Cardiovascular, Hospital Clinico San Carlos, Madrid, Spain.
authors.forename: Raúl
authors.initials: R
authors.lastname: Moreno
authors.forename: José L
authors.initials: JL
authors.lastname: Zamorano
authors.forename: Lucía
authors.initials: L
authors.lastname: Alvarez
authors.forename: Carlos
authors.initials: C
authors.lastname: Almería
authors.forename: Luis
authors.initials: L
authors.lastname: Mataix
authors.forename: José L
authors.initials: JL
authors.lastname: Rodrigo
authors.forename: Dionisio
authors.initials: D
authors.lastname: Herrera
authors.forename: Esther
authors.initials: E
authors.lastname: De Marco
authors.forename: Adalia
authors.initials: A
authors.lastname: Aubele
authors.forename: Luis
authors.initials: L
authors.lastname: Sánchez-Harguindey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D015150:Echocardiography, Doppler; D001330:Electronic Data Processing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging