Aerobic exercise training fails to lower hypertriglyceridemia levels in persons with advanced HIV-1 infection.
The purpose of this study was to determine whether blood lipid and lipoprotein concentrations varied in 5 men with advanced HIV-1 infection after 12 months of aerobic exercise training. Prior to exercise, the mean baseline cholesterol and high-density lipoprotein cholesterol (HDL-C) serum concentration were each lower, and mean baseline triglyceride concentration was higher compared to a healthy population norm. Consistent exercise training for 12 months failed to significantly (p > .05) alter cholesterol or HDL-C. Triglyceride concentration was significantly (p < .05) elevated above baseline (63 mg/dL) regardless of exercise compliance. The results suggest that long-term exercise training cannot correct lipid profile abnormality, particularly hypertriglyceridemia, common to individuals with advanced HIV-1 infection.
Birk
Thomas J
TJ
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
MacArthur
Rodger D
RD
Lipton
Lynn M
LM
Levine
Sheldon D
SD
D018791:CD4 Lymphocyte Count; D002784:Cholesterol / Q000097:blood; D015444:Exercise; D015658:HIV Infections / Q000150:complications* / Q000451:nursing; D015497:HIV-1; D006801:Humans; D006937:Hypercholesterolemia / Q000517:prevention & control* / Q000821:virology; D015228:Hypertriglyceridemia / Q000517:prevention & control* / Q000821:virology; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol