title: Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk.
abstract: The aim of this study was to estimate whether the Ile184Arg polymorphism of the Interferon, alpha 17 (IFNA17) gene might be correlated with the risk and prognosis of cervical squamous cell carcinoma (SCCA). Genomic DNA from 173 patients with invasive cervical SCCA and from 198 non-cancer controls (NCC) was examined for the Ile184Arg polymorphism with a polymerase chain reaction-restriction fragment length polymorphism-based assay. All P values are from two-sided tests. The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345). A significant increase in 184Ile homozygote frequency was found in the SCCA patients compared with the NCC group (odds ratio 2.96; 95% confidence interval 1.53-5.73; P=0.001). However, differences in clinicopathologic prognostic factors and in the 5 year survival rate were not significant among the subjects of each genotype group (P>0.05). The results of this study suggest that the 184Ile homozygote of the IFNA17 gene may represent an important susceptibility biomarker for cervical cancer risk.
authors.affiliation: Department of Obstetrics and Gynaecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Chongno-Ku, Seoul 110-744, South Korea. kjwksh@snu.ac.kr
authors.forename: Jae Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Ju Won
authors.initials: JW
authors.lastname: Roh
authors.forename: Noh Hyun
authors.initials: NH
authors.lastname: Park
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Song
authors.forename: Soon Beom
authors.initials: SB
authors.lastname: Kang
authors.forename: Hyo Pyo
authors.initials: HP
authors.lastname: Lee
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D016898:Interferon-alpha; D007372:Interferons / Q000235:genetics*; D007723:Korea / Q000453:epidemiology; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000235:genetics
chemical_list: C471357:IFNA17 protein, human; D016898:Interferon-alpha; D007372:Interferons