title: Application of fungi as biocatalysts for the reduction of diethyl 1-oxoalkylphosphonates in anhydrous hexane.
abstract: Five different species of microorganisms, namely, Rhodotorula rubra, Rhodotorula glutinis, Cladosporium sp., Verticillium sp., and baker's yeast, turned out to be useful biocatalysts for enantioselective reduction of a variety of diethyl 1-oxoalkylphosphonates. To suppress substrate decomposition, bioreductions were carried out under anhydrous conditions, using lyophilized cells immobilized on Celite R 630. The influence of reaction conditions such as biotransformation time and chemical additives on the yield of the reaction is discussed.
authors.affiliation: Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wrocław, Poland.
authors.forename: Małorzata
authors.initials: M
authors.lastname: Brzezińska-Rodak
authors.forename: Ewa
authors.initials: E
authors.lastname: Zymańczyk-Duda
authors.forename: Paweał
authors.initials: P
authors.lastname: Kafarski
authors.forename: Barbara
authors.initials: B
authors.lastname: Lejczak
mesh_terms: D001711:Biotransformation; D005612:Freeze Drying; D005658:Fungi / Q000378:metabolism*; D006586:Hexanes; D006865:Hydrogenation; D007659:Ketones / Q000378:metabolism; D063065:Organophosphonates / Q000378:metabolism*; D010084:Oxidation-Reduction; D012997:Solvents
chemical_list: D006586:Hexanes; D007659:Ketones; D063065:Organophosphonates; D012997:Solvents