Synthesis of C-3' methyl taxotere (docetaxel).
Protected (3R,4S)-N-Boc-3-hydroxy-4-methyl-4-phenylazetidin-2-one has been synthesized stereoselectively and used to esterify protected 10-desacetylbaccatin III to give, following removal of the protecting groups, novel C-3' methyl taxotere (docetaxel).
Lucatelli
Christophe
C
LEDSS, Université Joseph Fourier, Chimie Recherche, BP 53X, 38041 Grenoble Cedex, France.
Viton
Florian
F
Gimbert
Yves
Y
Greene
Andrew E
AE
D020650:Combinatorial Chemistry Techniques; D000077143:Docetaxel; D004951:Esterification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D043823:Taxoids
D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel