title: Spontaneous activity in premature infants affects bone strength.
abstract: OBJECTIVE
  Determination of bone strength of lower extremities in very low birth weight (VLBW) premature infants with central nervous system pathology resulting in reduced unilateral spontaneous leg movements.
  
  
  METHODS
  Quantitative ultrasound (QUS) measurements of speed of sound (SOS) of the tibiae of both legs in three VLBW premature infants with brain insult and unilateral reduced spontaneous activity. Results were compared to QUS measurements of both legs in healthy premature infants. Measurements were performed by the same investigator who was blinded to the clinical course of the participants.
  
  
  RESULTS
  Reduced spontaneous activity of one leg due to brain pathology resulted in decreased tibial SOS in the affected side. There was no difference in bone SOS between the legs of the healthy controls.
  
  
  CONCLUSIONS
  Spontaneous movements (mainly antigravity flexion and extension) are important for bone structure and mineralization in VLBW premature infants. QUS may become an important diagnostic modality for the evaluation, treatment, and follow-up of bone strength and osteopenia in this unique population.
authors.affiliation: Department of Pediatrics, Meir Hospital, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Eliakim
authors.forename: Dan
authors.initials: D
authors.lastname: Nemet
authors.forename: Orit
authors.initials: O
authors.lastname: Friedland
authors.forename: Tzipora
authors.initials: T
authors.lastname: Dolfin
authors.forename: Rivka H
authors.initials: RH
authors.lastname: Regev
mesh_terms: D002493:Central Nervous System Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D007866:Leg / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D014463:Ultrasonography