Micellar electrokinetic chromatography: current developments and future.
This review highlights recent methodological and instrumental advances in micellar electrokinetic chromatography (MEKC). Enhancements in sensitivity and selectivity of the technique through the use of on-line preconcentration approaches (stacking and sweeping) and nonconventional pseudostationary phases, namely nonionic and zwitterionic surfactants, mixed micelles and polymers, are discussed in detail. Laser-induced fluorescence and mass spectrometry, as alternatives to UV-absorption detection, have been covered to evaluate their advantages and limitations when applied to analysis in an MEKC format. Some thoughts on future directions in this area such as in-capillary reactions, coated capillaries and MEKC on microchips are also presented.
Molina
Manuel
M
Department of Analytical Chemistry, Edificio Marie Curie (Anexo), Campus de Rabanales, University of Córdoba, Córdoba, Spain.
Silva
Manuel
M
D020374:Chromatography, Micellar Electrokinetic Capillary / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D004867:Equipment Design; D007834:Lasers; D013058:Mass Spectrometry; D013501:Surface-Active Agents / Q000737:chemistry
D013501:Surface-Active Agents