title: A high voltage RF oscillator for driving multipole ion guides.
abstract: A high voltage RF oscillator circuit has been designed and constructed for driving multipole ion guides. The circuit is tunable from 500 kHz to 1.5 MHz by changing a capacitor and provides 0-1000 V(p-p) that is controlled by a 0-10 V input using a negative feedback circuit. This inexpensive circuit uses a set of high voltage transistors oscillating in tandem and does not require tuning of the resonance drive frequency as the oscillator automatically resonates at the (LC)(-1/2) frequency. Matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry (MALDI-FTMS) mass spectra were acquired using this tunable RF oscillator circuit to allow transmission of protein ions in the 8.5-39 kDa range through the quadrupole ion guide from the ion source to the mass analyzer.
authors.affiliation: Department of Biochemistry, Boston University School of Medicine Mass Spectrometry Resource, Boston, Massachusetts 02118, USA. poconnor@bu.edu
authors.forename: Peter B
authors.initials: PB
authors.lastname: O'Connor
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Costello
authors.forename: William E
authors.initials: WE
authors.lastname: Earle
mesh_terms: D004581:Electronics; D005583:Fourier Analysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation*; D014173:Transistors, Electronic