title: Myocardial viability independently influences left ventricular diastolic function in the early phase after acute myocardial infarction.
abstract: BACKGROUND
  After acute myocardial infarction, a broad range of left ventricular (LV) end-diastolic pressure (LVEDP) is expected because of chamber remodeling. However, intrinsic characteristics of the infarcted tissue (necrosis or viability) may also play a role. We aimed to evaluate whether myocardial viability (Mviab) has an influence on LVEDP.
  
  
  METHODS
  One hundred twenty-three consecutive patients with acute myocardial infarction underwent low-dose dobutamine echocardiography (5-10 microg/kg/min) to assess Mviab. Mviab was quantitatively evaluated by the variation of Delta wall motion score index. Patients underwent left heart catheterization with recording of LVEDP and a complete echocardiographic examination with measurement of LV volumes, ejection fraction, and mass.
  
  
  RESULTS
  The overall population (81% male; mean age 58 +/- 10 years) was divided into 2 groups according to the presence (group 1; 66 patients) or absence (group 2; 57 patients) of Mviab. LVEDP was higher in patients without Mviab (16 +/- 8 vs 20 +/- 7 mm Hg; P =.02). The multivariate analysis showed that Delta wall motion score index correlated with LVEDP (P =.01) independent of wall motion score index and LV end-systolic volume.
  
  
  CONCLUSIONS
  After acute myocardial infarction, LVEDP shows wide variability and is independently associated with Mviab.
authors.affiliation: Dipartimento di Scienze Biomediche e Chirurgiche, Sezione di Cardiologia, Universita' di Verona, Italy. Andrea.Rossi@univr.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Rossi
authors.forename: Mariantonietta
authors.initials: M
authors.lastname: Cicoira
authors.forename: Maurizio
authors.initials: M
authors.lastname: Anselmi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Golia
authors.forename: Loredana
authors.initials: L
authors.lastname: Latina
authors.forename: Monica
authors.initials: M
authors.lastname: Tinto
authors.forename: Piero
authors.initials: P
authors.lastname: Zardini
authors.forename: Jae K
authors.initials: JK
authors.lastname: Oh
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D013318:Stroke Volume / Q000502:physiology; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020257:Ventricular Remodeling / Q000502:physiology*