title: IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation.
abstract: The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.
authors.affiliation: INSERM U387, Hôpital Sainte-Marguerite, 270 Boulevard de Sainte-Marguerite, 13009 Marseille, France. gkaplanski@marseille.inserm.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Kaplanski
authors.forename: Valérie
authors.initials: V
authors.lastname: Marin
authors.forename: Félix
authors.initials: F
authors.lastname: Montero-Julian
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Catherine
authors.initials: C
authors.lastname: Farnarier
mesh_terms: D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology* / Q000378:metabolism*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D009000:Monocytes / Q000166:cytology / Q000276:immunology*; D009504:Neutrophils / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6