Bradykinin sensitivity in primary open-angle glaucoma and normal-tension glaucoma patients.
OBJECTIVE
To report the reaction after intradermal injection of bradykinin in nonglaucoma, primary open-angle glaucoma, and normal-tension glaucoma subjects.


METHODS
Prospective comparative study.


METHODS
The study participants were 14 healthy control subjects, 16 patients with primary open-angle glaucoma, and 15 patients with normal-tension glaucoma. In each participant, the wheal response to intradermal injection of 10 microg bradykinin in the volar forearm was measured by a masked observer.


RESULTS
There was no significant difference in the wheal response to bradykinin between control subjects and primary open-angle glaucoma patients (P =.73) and between primary open-angle glaucoma patients and normal-tension glaucoma patients (P =.09). However, there was a significant difference in the wheal response to bradykinin between control subjects and normal-tension glaucoma patients (P =.04).


CONCLUSIONS
These in vivo structure-activity studies may suggest abnormalities of the tissue kallikrein-kinin system in normal-tension glaucoma.
Hirooka
Kazuyuki
K
Department of Ophthalmology, Kagawa Medical University, Miki, Kagawa, Japan. kazuyk@kms.ac.jp
Shiraga
Fumio
F
Hasegawa
Eiichi
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001920:Bradykinin / Q000494:pharmacology*; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D016234:Kallikrein-Kinin System / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D001920:Bradykinin