title: Antimicrobial activity of Michelia champaca.
abstract: The methanol extracts of leaves, seeds, stem and root barks, stem and root heart-woods of Michelia champaca and the obtained fractions (petrol, dichloromethane, ethyl acetate, butanol) exhibited a broad spectrum of antibacterial activity. Fractionation drastically enhanced the level of activity particularly in all fractions of the stem bark and dichloromethane fraction of the root bark. Some fractions of the leaves, stem and root barks demonstrated antifungal activity against some of the tested moulds. Liriodenine was the active constituent of the root bark, with a broader and, in some cases, better level of activity as compared to the standard.
authors.affiliation: Department of Applied Sciences, Papua New Guinea University of Technology, PMB Lae, Papua New Guinea. rkhan@dg.gcom.pg
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Kihara
authors.forename: A D
authors.initials: AD
authors.lastname: Omoloso
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D056890:Eukaryota / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D029562:Magnoliaceae / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018514:Plant Structures / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts