Adipose tissue as an endocrine organ.
Adipose tissue is a highly active endocrine organ secreting a range of soluble products with both local and distant actions. These hormones have important roles in metabolism, reproduction, cardiovascular function and immunity. It is now evident that adipose endocrine function directly influences other organ systems, including the brain, liver and skeletal muscle. The endocrine function of adipose tissue is significantly regulated by nutritional status, and both are inextricably linked to the energy storage role of adipose tissue. This chapter highlights the endocrinology of adipose tissue by concentrating on functional aspects of the secreted products. The data of particular relevance to humans are highlighted, and areas in need of future research are suggested.
Prins
Johannes B
JB
Princess Alexandra Hospital, Ipswich Rd, Woolloongabba 4102, Australia.
D052242:Adiponectin; D000273:Adipose Tissue / Q000502:physiology*; D000305:Adrenal Cortex Hormones; D054366:Agouti Signaling Protein; D000818:Animals; D004702:Endocrine Glands; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified; D012739:Gonadal Steroid Hormones; D006801:Humans; D007109:Immunity; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D011506:Proteins; D012084:Renin-Angiotensin System; D014409:Tumor Necrosis Factor-alpha
D052242:Adiponectin; D000305:Adrenal Cortex Hormones; D054366:Agouti Signaling Protein; D005230:Fatty Acids, Nonesterified; D012739:Gonadal Steroid Hormones; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha