Routes to fluorinated organic derivatives by nickel mediated C-F activation of heteroaromatics.
New fluorinated azaheterocycles can be synthesised regio- and chemo-selectively via C-F activation of fluorinated precursors at nickel, with subsequent functionalisation and release from the coordination sphere of the metal; the requirements for productive C-F activation are significantly different from those for C-H bond activation.
Braun
Thomas
T
Fakultät für Chemie, Universität Bielefeld, Postfach 100131, 33501 Bielefeld, Germany. thomas.braun@uni-bielefeld.de
Perutz
Robin N
RN