[Morphogenesis of thoracic aorta aneurysms: investigation of matrix metalloproteinases and their tissue inhibitors].
The matrix metalloproteinases are a large group of proteases with a central role of the degradation of all types of extracellular matrix. The present study investigated expression of matrix metalloproteinases (MMP-1, -2, -9) and their inhibitors (TIMP-1, -2) in chronic Aneurysm of the Thoracic Aorta (ATA) and Post-Stenotic Dilatation of the ascending aorta due to valvular aortic stenosis (PSD). Fragments of the ascending aorta that had been taken from the patients during coronary by-pass surgery were used as controls. Immunohistochemical investigation showed that medical SMC in the samples taken from aortas with ATA and PDS expressed a stronger immunoreactivity for MMP-1, -2, -9 and TIMP-1, -2 as compared to controls. It can be suggested that during formation of ATA and PSD, production of MMPs and TIMPS by medial smooth muscle cells is of great importance.
Lesauskaite
Vaiva
V
Kauno medicinos universiteto Kardiologijos institutas. vaivales@kmu.lt
Tanganelli
Piero
P
D000367:Age Factors; D000368:Aged; D001013:Aorta, Thoracic / Q000378:metabolism / Q000473:pathology; D017545:Aortic Aneurysm, Thoracic / Q000201:enzymology* / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology; D003627:Data Interpretation, Statistical; D004108:Dilatation, Pathologic; D005260:Female; D006651:Histocytochemistry; D006652:Histological Techniques; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008875:Middle Aged; D009024:Morphogenesis; D012737:Sex Factors; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*; D017540:Tunica Media / Q000201:enzymology / Q000378:metabolism / Q000473:pathology
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases