[The use of a beta-blocker esmolol in patients with acute myocardial infarction treated with streptokinase].
Infusion of esmolol (50-300 mcg/kg/min, mean 119-/+75.5 mcg/kg/min, average duration 3.2-/+1.22 h)) was carried out in 49 streptokinase treated patients within 6 hours of myocardial infarction. Infusion was associated with slowing of heart rate and lowering of mean dynamic systolic blood pressure (by 22%). No changes of stroke volume and index occurred. Complications requiring either cessation of infusion or decrease of its rate developed in 14.3% of patients (lowering of systolic blood pressure below 100 mm Hg in 5, complete atrio-ventricular block in 2) as a rule in the beginning of the infusion.
Shalaev
S V
SV
Bukhvalov
V A
VA
Petrik
E S
ES
Shabalkov
E A
EA
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010960:Plasminogen Activators / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D010960:Plasminogen Activators; C036604:esmolol