Embryonic hematopoiesis in mice and humans.
OBJECTIVE
The aim of this report is to review briefly the ontogeny of hematopoiesis in mice and humans and to discuss recent evidence for an intraembryonic source of hematopoietic stem cells.


METHODS
The hematopoiesis overview summarizes information present in the PubMed online database and from experiments conducted in our laboratories.


RESULTS
The major sites of hematopoiesis change throughout development in mice and humans. Recent evidence suggests that hematopoietic cells may emerge from mesoderm precursors within the embryo as well as in the yolk sac.


CONCLUSIONS
The ontogeny of hematopoiesis is similar in mice and humans. The murine system is a useful model to study the earliest events involved in forming hematopoietic stem cells.
Yoder
M C
MC
myoder@iupui.edu
D000818:Animals; D005314:Embryonic and Fetal Development; D006410:Hematopoiesis / Q000502:physiology*; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006413:Hematopoietic System / Q000196:embryology*; D006801:Humans; D051379:Mice; D012680:Sensitivity and Specificity; D013045:Species Specificity; D015017:Yolk Sac / Q000502:physiology*