Smads "freeze" when they ski.
The transforming growth factor-beta (TGF-beta) signal is manifest through activated heteromeric Smad complex-mediated transcriptional modulation of target genes that translates into diverse, context-specific biologic effects, such as the potent TGF-beta-initiated cytostatic program. The TGF-beta pathway is effectively antagonized through the direct binding and subsequent repression of activated Smad heteromeric complexes by the Ski family of proto-oncoproteins.
Frederick
Joshua P
JP
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. jpf1@duke.edu
Wang
Xiao-Fan
XF
D004268:DNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction; D051785:Smad Proteins; D015534:Trans-Activators / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D004268:DNA-Binding Proteins; D051785:Smad Proteins; D015534:Trans-Activators; D016212:Transforming Growth Factor beta