title: Haemophilus influenzae type b (Hib) antibody concentrations and vaccination responses in patients with chronic lymphocytic leukaemia: predicting factors for response.
abstract: We have recently demonstrated a moderate vaccination response rate of 43% against Haemophilus influenzae type b (Hib) conjugate vaccine among adult and elderly patients with chronic lymphocytic leukaemia (CLL). We now investigated demographic and immunological factors predicting the favourable response and protective antibody concentrations for Hib conjugate vaccine in CLL. Lower age was associated with protective pre- and post-vaccination antibody concentrations. High IgG1 and IgA concentrations were also associated with the protective efficacy. High IgM, in turn, was the best predictor of a significant vaccination response. Again, lower age seemed to be involved in this outcome. Judging from these findings, it would seem beneficial to vaccinate all CLL patients with conjugate vaccines at the presentation of the disease. Investigations of a new pneumococcal conjugate vaccine in CLL are warranted.
authors.affiliation: Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, FIN-33521, Tampere, Finland. marjatta.sinisalo@tays.fi
authors.forename: Marjatta
authors.initials: M
authors.lastname: Sinsalo
authors.forename: Janne
authors.initials: J
authors.lastname: Aittoniemi
authors.forename: Helena
authors.initials: H
authors.lastname: Käyhty
authors.forename: Juhani
authors.initials: J
authors.lastname: Vilpo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D016667:Bacterial Capsules; D005260:Female; D006192:Haemophilus Infections / Q000209:etiology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D011292:Premedication; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D007132:Immunoglobulin Isotypes; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate