The web and the rock: cell adhesion and the ARP2/3 complex.
Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells.
Kovacs
Eva M
EM
School for Biomedical Science, The University of Queensland, St. Lucia, Brisbane, Australia.
Yap
Alpha S
AS
D008841:Actin Cytoskeleton / Q000378:metabolism*; D051377:Actin-Related Protein 2; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D011554:Pseudopodia / Q000378:metabolism*; D016596:Vinculin / Q000378:metabolism
C495926:ACTR2 protein, human; D051377:Actin-Related Protein 2; D003598:Cytoskeletal Proteins; D016596:Vinculin