Successful treatment of advanced peripheral T-cell lymphoma with an angiocentric growth pattern complicated with hemophagocytic syndrome by high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries, respond poorly to therapy, and have short survival with no sustained remission. Furthermore, the complication of hemophagocytic syndrome (HPS) sometimes makes the prognosis of this disease extremely worse. We report here a case of PTCL with an angiocentric growth pattern complicated with HPS successfully treated by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Our case suggests this approach is an excellent candidate for the treatment of this disease.
Sato
T
T
Department of Internal Medicine (Section 4), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Japan. ben_sato@hotmail.com
Kogawa
K
K
Iyama
S
S
Kobayashi
D
D
Sato
Y
Y
Kuribayashi
K
K
Takada
K
K
Hagiwara
S
S
Oku
T
T
Takahashi
S
S
Matsunaga
T
T
Takahashi
M
M
Terui
T
T
Kato
J
J
Niitsu
Y
Y
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction / Q000379:methods; D014182:Transplantation, Autologous
D005047:Etoposide; D016190:Carboplatin; D007069:Ifosfamide