[Relationship between vaginal sialidase bacteria vaginosis and chorioammionitis].
OBJECTIVE
To study the relationship among vaginal sialidase, bacterial vaginosis (BV), chorioammionitis and subsequent adverse outcome of pregnancy.


METHODS
Vaginal sialidase was measured by colorimetry in samples of vaginal discharges from 80 pregnant women with BV (study group) and 60 normal pregnant women at same gestation weeks (control group). Color turning blue means positive of sialidase activity, and no color changing means negative. The diagnosis of chorioammionitis was based on pathological examination.


RESULTS
Ninety six dot three percent, 3.3% exhibited sialidase activities in study group and control group, respectively. There were significant differences between these two groups (P < 0.001). By measuring vaginal sialidase activity, the sensitivity, specificity, positive and negative predictive value in diagnosing BV were 96.3%, 96.7%, 97.5% and 95.1%, respectively. Chorioammionitis, premature rupture of membranes, premature delivery and puerperal infection in sialidase positive group were significantly higher than the negative group. Sensitivity, specialty of sialidase activity for chorioammionitis were 87.5%, 50.0%, respectively.


CONCLUSIONS
Vaginal sialidase activity has strong relation with bacterial vaginosis. Measuring vaginal sialidase activity is a fast, easy, and useful method to diagnose bacterial vaginosis. It also has relation with chorioammionitis and subsequent adverse outcome of pregnancy.
Zhang
Xin
X
Teaching and Research Section of Obstetrics and Gynecology, the Second Health School of Zaozhuang, Shandong Province, Zaozhuang 277500, China.
Xu
Xingli
X
Li
Jinfeng
J
Li
Nan
N
Yan
Tingfeng
T
Ju
Xiuqing
X
D002821:Chorioamnionitis / Q000175:diagnosis* / Q000201:enzymology; D005260:Female; D006801:Humans; D009439:Neuraminidase / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012680:Sensitivity and Specificity; D014621:Vagina / Q000201:enzymology*; D016585:Vaginosis, Bacterial / Q000175:diagnosis* / Q000201:enzymology
D009439:Neuraminidase