The heart as an endocrine organ.
The discovery of atrial natruietic peptide firmly established that the heart was not just a pump and provided the long-sought-after link between the heart and the kidney in the control of soduim balance. Pharmacological targeting of the natruiretic peptide system is now leading to novel advances in the treatment of hypertension and of heart failure - two of the most common causes of human disability and death.
Sagnella
Guiseppe A
GA
St George's Hospital Medical School, London, UK. g.sagnella@sghms.ac.uk
D009320:Atrial Natriuretic Factor / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D004702:Endocrine Glands / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D009320:Atrial Natriuretic Factor; D012964:Sodium; D017461:Receptors, Atrial Natriuretic Factor