title: Network activity in neurons of the motor and prefrontal areas of the cortex in trained cats in conditions of systemic administration of m-cholinoreceptor blockers.
abstract: Experiments on five cats already trained to an operant conditioned food-procuring reflex to light were used to study the network activity of cells in the frontal and motor areas of the cortex accompanying disruption of conditioned reflex behavior in conditions of systemic administration of m-cholinoreceptor blockers. The activity of cortical neurons and their network properties were assessed using auto- and cross-correlation histograms. Doses of central m-cholinoreceptor blockers (the non-selective blocker scopolamine and the relatively selective m1-cholinoreceptor blocker trihexyphenidyl) disrupted performance of the operant motor reflex but had no effect on the appearance of contextual behavior and responses to switching on of the conditioned signal (standing up, elevating the paw). This was accompanied by 1) changes in the patterns of neuron activity in the moor and frontal areas of the cortex, with increases in train, rhythmic, and rhythmic train activity in cortical cells; 2) appearance of synchronicity in the operation of cortical neurons; 3) decreases in the numbers of direct interneuronal connections in the motor and frontal areas of the cortex and in the numbers of connections between these structures.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: V N
authors.initials: VN
authors.lastname: Khokhlova
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Merzhanova
authors.forename: E E
authors.initials: EE
authors.lastname: Dolbakyan
mesh_terms: D000818:Animals; D002415:Cats; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004594:Electrophysiology; D008845:Microinjections; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology*; D009068:Movement / Q000187:drug effects; D009415:Nerve Net / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology; D014282:Trihexyphenidyl / Q000494:pharmacology
chemical_list: D018680:Cholinergic Antagonists; D011950:Receptors, Cholinergic; D014282:Trihexyphenidyl; D012601:Scopolamine