A diffusion tensor MRI study of basal ganglia from patients with ADEM.
Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ((-)D) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average (-)D (p=0.02) and lower (-)D histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.
Holtmannspötter
Markus
M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Inglese
Matilde
M
Rovaris
Marco
M
Rocca
Maria Assunta
MA
Codella
Maria
M
Filippi
Massimo
M
D000328:Adult; D001479:Basal Ganglia / Q000473:pathology*; D004673:Encephalomyelitis, Acute Disseminated / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012016:Reference Values