title: Brainstem auditory evoked response in adolescents with acoustic mycotic neuroma due to environmental exposure to toxic molds.
abstract: Indoor air contamination with toxic opportunistic molds is an emerging health risk worldwide. Some of the opportunistic molds include: Stachybotrys chartarum, Aspergillus species (A. fumigatus, A. flavus, A. niger, A. versicolor etc.), Cadosporium, Alternaria, Penicillium, Trichoderma, Fusarium graminearum etc. These molds flourish in homes that are moist and damp. Reports of floods are now evident in many parts of the world. With these global changes in climatic conditions that favor the opportunistic mode of living among these molds, some health authorities are beginning to feel concerned about the diversity and the extent to which opportunistic molds can cause adverse health effects in humans. Mycotoxicosis is the collective name for all the diseases caused by toxic molds. Frequently, we have cases of acoustic neuroma due to mycotoxicity in our Center. Mycotic neuroma probably has not been reported before and the application of brainstem auditory evoked response (BAER) techniques in acoustic mycotic neuroma have not been reported either. The aim of this study, therefore, was to report cases and measurements of acoustic mycotic neuroma in adolescents using the brainstem auditory evoked response. The patients' case history, clinical neurological and neurobehavioral questionnaires were assessed. Then, the BAERs were recorded between Cz and Ai, with a second channel, Cz-Ac. The case histories and the questionnaires were analyzed in conjunction with the outcome of the objective brainstem auditory evoked response measurements. The prevalent subjective findings in the patients were headaches, memory loss, hearing loss, lack of concentration, fatigue, sleep disturbance, facial swelling, rashes, nosebleeds, diarrhea, abdominal pains and respiratory difficulties. Objective BAER showed overall abnormalities in all the patients. Although the waveform abnormalities varied, 1-3 interpeak latencies were abnormal in all the patients. Overall results showed the presence of acoustic mycotic neuroma and confirmed the sensitivity and usefulness of BAER in screening acoustic mycotic neuroma and sensorineural auditory dysfunction.
authors.affiliation: Center for Immune, Environmental and Toxic Disorders, 25010 Oakhurst, Suite 200, Spring, Texas 77386, USA. eanyanwu@hotmail.com
authors.forename: Ebere
authors.initials: E
authors.lastname: Anyanwu
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Campbell
authors.forename: William
authors.initials: W
authors.lastname: High
mesh_terms: D000293:Adolescent; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D016057:Evoked Potentials, Auditory, Brain Stem; D006801:Humans; D008297:Male; D009181:Mycoses / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D020953:Neuroaspergillosis / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D009464:Neuroma, Acoustic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D018877:Sick Building Syndrome; D013191:Stachybotrys