Rheological behavior and the SPF of sunscreens.
Due to a large variety of sunscreens, it is important to study among other things, the effect of the vehicle on the thickness and uniformity of sunscreen films. In this study, we determined the physical stability of five sunscreens SPF 15 (FA to FG), containing or not PVP/eicosene crosspolymer (PVP/EC), and two different self-emulsifying bases (SEB), and also evaluated the influence of the vehicle in their SPF. In the study of physical stability, formulations were stored at 25, 37 and 45 degrees C, for 28 days. Viscosity and rheological behavior of the formulations were determined using a Brookfield rheometer. Investigations of the SPF were carried out in a group of 30 volunteers (COLIPA methodology). The FC samples (phosphate-based SEB), with a lower thixotropy, showed statistically higher SPF (13.6) when compared with FB (non-ionic SEB), which presented higher thixotropy and a SPF of 9.84. The FE sample (phosphate-based SEB+PVP/EC) presented the same SPF as the FC, but had a higher thixotropy. The FB formulation (stable with higher thixotropy) showed the lowest SPF while FC (an unstable formulation with lower thixotropy) presented a higher SPF. We concluded that FE was the best formulation showing a higher SPF and stability and the study of rheology can help the development of sunscreens.
Gaspar
L R
LR
Laboratory of Cosmetic Technology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Bairro Monte Alegre, Ribeirão Preto, SP, Brazil.
Maia Campos
P M B G
PM
D011835:Radiation Protection; D013472:Sunlight; D013473:Sunscreening Agents / Q000737:chemistry*; D014783:Viscosity
D013473:Sunscreening Agents