Successful treatment of neuroborreliosis with ten day regimens.
BACKGROUND
There have been few large reports of the treatment and outcome of neuroborreliosis in children.


METHODS
All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 through 1996 were included. Children were treated with intravenous beta-lactam antibiotics or oral doxycycline for 10 days and followed until the resolution of symptoms.


RESULTS
At the end of treatment 58% and after 2 months 92% of the children had no symptoms. Cerebrospinal fluid findings had no statistically significant influence on the outcome. Facial paralysis persisted longer than other symptoms.


CONCLUSIONS
The prognosis of neuroborreliosis in children 2 months after treatment seems to be excellent with 10-day treatment regimens.
Thorstrand
Carita
C
Sachsska Children's Hospital, Stockholm, Sweden.
Belfrage
Erik
E
Bennet
Rutger
R
Malmborg
Petter
P
Eriksson
Margareta
M
D000284:Administration, Oral; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007769:Lactams / Q000008:administration & dosage; D020852:Lyme Neuroborreliosis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011336:Probability; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology; D016896:Treatment Outcome
D007769:Lactams; D004318:Doxycycline