Laser Doppler flowmetric determination of ureteral blood flow after ureteral access sheath placement.
OBJECTIVE
The ureteral access sheath has positively impacted ureteroscopy by decreasing operative times and increasing success rates. However, as previous studies have suggested that large-caliber endoscopes may cause ureteral ischemia, concern has been raised about the impact of access sheath insertion on ureteral blood flow. We sought to determine whether the access sheath compromises ureteral blood supply and, if so, causes ischemic damage to the ureter during ureteroscopic procedures.


METHODS
Using a swine animal model, ureteral blood flow was measured with a laser Doppler flowmeter. Eleven ureteral units were randomized into four study groups: those dilated with 10F-12F, 12F-14F, and 14F-16F access sheaths (N = 3 per group) and an undilated control group (N = 2). Blood flow measurements were obtained from the proximal ureter via laser Doppler flowmetry for 70 minutes at 5-minute intervals. Hemodynamic variability was controlled for through intraoperative heart rate and oxygen saturation monitoring, as well as a second Doppler probe that was placed on the animal's skin, from which readings were also taken every 5 minutes. Results were correlated with histopathologic findings.


RESULTS
The control group demonstrated little ureteral blood flow variability over the course of 70 minutes. The study groups that were dilated with sheaths, however, all showed a decrease in ureteral blood flow after access sheath insertion, with the flow in animals dilated with 12F-14F and 14F-16F sheaths dropping below 50% of baseline. This initial drop in blood flow was followed by a gradual increase from nadir toward baseline values over the course of the study. On average, the 14F-16F group reached nadir more quickly and took longer to restore its ureteral blood flow. All animals remained hemodynamically stable throughout the study, showing only minimal variability in heart rate, oxygen saturation, and skin blood flow over the 70-minute experiment. Histologically, there was no evidence of ischemic damage in any of the study groups at 72 hours.


CONCLUSIONS
In this animal model, the access sheath does cause a transient decrease in ureteral blood flow. Nonetheless, compensatory mechanisms of the ureteral wall restore blood flow to near-baseline rates and preserve urothelial integrity, suggesting that use of the ureteral access sheath remains a safe adjunct to flexible ureteroscopy. Because the chronic effects of the access sheath have yet to be elucidated, care must be taken in selecting an appropriate-size sheath for each individual case. Preventive measures may be available to help avoid sheath-related ureteral injury in those patients identified as high risk.
Lallas
Costas D
CD
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
Auge
Brian K
BK
Raj
Ganesh V
GV
Santa-Cruz
Robert
R
Madden
John F
JF
Preminger
Glenn M
GM
D000818:Animals; D002404:Catheterization / Q000009:adverse effects / Q000379:methods; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D007511:Ischemia / Q000209:etiology / Q000473:pathology; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D012039:Regional Blood Flow / Q000502:physiology; D013552:Swine; D014513:Ureter / Q000098:blood supply* / Q000601:surgery*; D018666:Ureteroscopy / Q000009:adverse effects / Q000379:methods*; D014570:Urologic Diseases / Q000209:etiology / Q000473:pathology