Synthetic approaches to the microtubule stabilizing agent (-)-laulimalide.
In the past few years, the microtubule stabilizing agent (-)-laulimalide has attracted considerable attention, as it could constitute a potential treatment for cancer. Several total syntheses of (-)-laulimalide have now been reported. This review summarizes available biological data and synthetic approaches to (-)-laulimalide, reported prior to July 2002.
Crimmins
Michael T
MT
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA. crimmins@email.unc.edu
D000818:Animals; D005079:Excipients / Q000138:chemical synthesis* / Q000378:metabolism; D006801:Humans; D018942:Macrolides; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism; D043823:Taxoids
D005079:Excipients; D018942:Macrolides; D043823:Taxoids; C117305:laulimalide; D017239:Paclitaxel