title: [Effects of fenvalerate exposure on the semen quality of occupational workers].
abstract: OBJECTIVE
  To study the effects of fenvalerate exposure on the semen quality of occupational workers in order to find out the early effective biomarkers.
  
  
  METHODS
  Thirty-two male workers who exposed to fenvalerate and 46 male administrators in the office in a pesticide factory were selected as the exposure group and internal control group, respectively, and 22 male administrators in a center for disease control were served as the external control group. In order to evaluate the exposed levels, the concentration of fenvalerate, toluene and xylene in the ambient air of working place in these three groups were monitored simultaneously for three consecutive days. After the semen were collected according to the standard method, the workers' semen qualities were analysed with University of California at Davis (UCDavis) method and the sperm motility were evaluated using computer assisted sperm analysis(CASA).
  
  
  RESULTS
  In the exposure group, the concentrations of fenvalerate were significantly higher than those in the internal and external control group (P < 0.01), while no significant difference of the concentration on toluene or xylene was found (P > 0.05). Sperm motion parameters in the exposure group such as linearity(LIN), straightness(STR), and the sperm count were decreased significantly, and the abnormality rate of viscidity, coagulation and sperm count were increased significantly as compared with the internal and the external control groups(P < 0.05). Furthermore, the sperm progression and beat cross frequency (BCF) in the exposure group were also lower significantly than those in the external control group(P < 0.05), while the abnormality rate of sperm progression was increased significantly.
  
  
  CONCLUSIONS
  In such a low concentration, occupational exposure to fenvalerate can affect workers' semen quality, especially the sperm count and sperm movement ability.
authors.affiliation: School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Tan
authors.forename: Shou-Lin
authors.initials: SL
authors.lastname: Wang
authors.forename: Xue-Zhao
authors.initials: XZ
authors.lastname: Sun
authors.forename: Yan-Nan
authors.initials: YN
authors.lastname: Li
authors.forename: Qian-Li
authors.initials: QL
authors.lastname: Wang
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Ji
authors.forename: Long-Sheng
authors.initials: LS
authors.lastname: Chen
authors.forename: Xin-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D000328:Adult; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009570:Nitriles; D016273:Occupational Exposure / Q000009:adverse effects*; D011722:Pyrethrins / Q000633:toxicity*; D012661:Semen / Q000187:drug effects*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate