Simple and efficient chemoselective mild deprotection of acetals and ketals using cerium(III) triflate.
A new and chemoselective method for the cleavage of alkyl and cyclic acetals and ketals at room temperature in wet nitromethane by using catalytic cerium(III) trifluoromethane sulfonate is presented. The high yields, the observed selectivity, the very gentle reaction conditions, and the almost neutral pH make this procedure particularly attractive for multistep synthesis.
Dalpozzo
Renato
R
Dipartimento di Chimica, Università della Calabria, I-87030 Arcavacata di Rende (CS), Italy.
De Nino
Antonio
A
Maiuolo
Loredana
L
Procopio
Antonio
A
Tagarelli
Antonio
A
Sindona
Giovanni
G
Bartoli
Giuseppe
G