Navigating the signalling network in mouse cardiac myocytes.
Cardiac myocytes have a complex network of signals that regulates their essential role in the rhythmic pumping of the heart. This network is an appealing model system in which to study the basic principles underlying cellular signalling mechanisms. Progress in this effort has come through the establishment of standardized myocyte isolation and culture procedures and characterization of important signalling responses.
Sambrano
Gilberto R
GR
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA. sambrano@cmp.ucsf.edu
Fraser
Iain
I
Han
Heping
H
Ni
Yan
Y
O'Connell
Tim
T
Yan
Zhen
Z
Stull
James T
JT
D000375:Aging; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002469:Cell Separation; D051379:Mice; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D012106:Research; D012107:Research Design; D015398:Signal Transduction