title: What can surface chemistry do for cell biology?
abstract: Recent research has enhanced the development of substrates that serve as models of extracellular matrix and their use in studies of cell adhesion and migration. Advances include the development of methods to prepare substrates having ligands immobilized in controlled densities and patterns, and recent work that is developing dynamic substrates which can modulate, in real-time, the activities of ligands. These technologies are providing new opportunities for studies of cell-extracellular-matrix interactions.
authors.affiliation: The University of Chicago, Department of Chemistry, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA. mmrksich@midway-uchicago.edu
authors.forename: Milan
authors.initials: M
authors.lastname: Mrksich
mesh_terms: D000327:Adsorption; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008024:Ligands; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties
chemical_list: D008024:Ligands; D011506:Proteins