The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K+ channels of the alga Nitella hookeri.
This paper communicates a new synthesis of the ion channel inhibitors NPPB and NPBB using a simple reductive amination sequence. The synthesised compounds were found to reduce channel amplitude of a K(+) channel present in cytoplasmic droplets of Nitella hookeri.
Giles
Kristian R
KR
Department of Plant and Microbial Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Humphries
Mark
M
Abell
Andrew
A
Garrill
Ashley
A
D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000460:Chlorophyta / Q000187:drug effects / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D007202:Indicators and Reagents; D007700:Kinetics; D009579:Nitrobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology*; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism
C475624:5-nitro-2-(4-phenylbutylamino)benzoic acid; D062365:Aminobenzoates; D007202:Indicators and Reagents; D009579:Nitrobenzoates; D026902:Potassium Channel Blockers; D015221:Potassium Channels; C058176:5-nitro-2-(3-phenylpropylamino)benzoic acid