title: Comparison between polyvinylpyrrolidone and silica nanoparticles as carriers for indomethacin in a solid state dispersion.
abstract: States of interaction between indomethacin (IM) and polyvinylpyrrolidone (PVP) in an amorphous solid dispersion prepared by co-grinding were compared with those between IM and silica nanoparticles. Changes in the carbon chemical states of the solid dispersions were evaluated based on the chemical shift in the 13C-CP/MAS-NMR. Hydrogen bonds between the amide carbonyl of PVP particles and the carboxyl groups of IM molecules were formed by co-grinding. Despite the wide difference in carrier properties, the apparent equilibrium solubility (AES) of IM in the ground IM-PVP mixture was predicted by solid state NMR on the basis of the relationship previously established for IM with SiO(2). This indicates that AES is affected solely by the state of IM, irrespective of the carrier species, and despite carrier-dependent chemical interactions.
authors.affiliation: Product Development Laboratories, Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. watatm@shina.sankyo.co.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Kusai
authors.forename: Mamoru
authors.initials: M
authors.lastname: Senna
mesh_terms: D004337:Drug Carriers; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011205:Povidone / Q000008:administration & dosage*; D012822:Silicon Dioxide / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide; D011205:Povidone; D007213:Indomethacin