Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat?
Gradolatto
A
A
UMR 0938 de Toxicologie Alimentaire, INRA-ENSBANA, 17 rue Sully, BP 86510, 21065 Dijon, France.
Teyssier
C
C
Stroheker
T
T
Chagnon
M C
MC
Canivenc-Lavier
M C
MC
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D047310:Apigenin; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019833:Genistein / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014316:Tritium; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
D000970:Antineoplastic Agents; D005419:Flavonoids; D014316:Tritium; D004958:Estradiol; D047310:Apigenin; D019833:Genistein