title: Influence of alcohol consumption on the association between serum lipids and colorectal adenomas.
abstract: BACKGROUND
  There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related. The purpose of this study was to evaluate the influence of alcohol consumption on the association between serum cholesterol levels and colorectal adenoma.
  
  
  METHODS
  The subjects were 1,349 male patients who underwent both barium enema examination and total colonoscopy. They answered a questionnaire regarding their alcohol consumption history, and their blood samples were analysed. The subjects were divided into three groups: those with no tumour (with neither adenoma nor adenocarcinoma), those with adenoma and those with adenocarcinoma. Among the groups, the serum total cholesterol and triglyceride levels were compared in all the patients, in the patients who did not drink daily and in the patients who did.
  
  
  RESULTS
  In all the patients, the serum cholesterol and triglyceride levels did not differ between the patients with and those without adenoma. In the daily drinkers, the serum cholesterol and triglyceride levels were significantly lower in patients with adenoma than in those without.
  
  
  CONCLUSIONS
  Significantly lower levels of serum cholesterol and triglycerides were found in daily drinkers with adenoma than in those without.
authors.affiliation: Third Dept. of Internal Medicine, Nippon Medical School, Tokyo, Japan. s-fujimori@nms.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Fujimori
authors.forename: T
authors.initials: T
authors.lastname: Kishida
authors.forename: K
authors.initials: K
authors.lastname: Mitsui
authors.forename: M
authors.initials: M
authors.lastname: Yonezawa
authors.forename: K
authors.initials: K
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Tatsuguchi
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Yokoi
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohaki
authors.forename: C
authors.initials: C
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000453:epidemiology; D000236:Adenoma / Q000097:blood* / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000097:blood* / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol