Monoclonal antibodies as therapeutics in oncology.
The specificity of antibodies has been harnessed to target cancer cells and the first therapeutic antibodies for use in oncology are now finding application in the clinic. Studies are currently under way to develop new and improved antibodies. Recent developments have been made in the identification of novel targets, including the use of genomic and proteomic technologies. Several methods are also being developed to enhance antibody efficacy.
Trikha
Mohit
M
Centocor Oncology Research, 200 Great Valley Parkway, Malvern, PA 19355, USA.
Yan
Li
L
Nakada
Marian T
MT
D000818:Animals; D000911:Antibodies, Monoclonal / Q000145:classification* / Q000276:immunology / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy / Q000379:methods; D017277:Drug Approval; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011786:Quality Control; D016499:Radioimmunotherapy / Q000379:methods
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm