title: Glucocorticoid resistance - what is known?
abstract: It has become apparent in recent years that the glucocorticoid receptor is not a simple on/off switch, but instead orchestrates subtle and complex interactions between large numbers of proteins. This more sophisticated understanding awaits a unifying concept that will explain mechanisms of glucocorticoid resistance and allow new approaches to enhancing sensitivity.
authors.affiliation: URCN, Division of Medicine, University of Bristol, Marlborough Street, BS2 8HW, Bristol, UK. m.r.norman@bris.ac.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Norman
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Hearing
mesh_terms: D004351:Drug Resistance; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D020239:Receptor Cross-Talk; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005938:Glucocorticoids; D018832:Molecular Chaperones; D011965:Receptors, Glucocorticoid