Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population.
OBJECTIVE
The genetic contribution to inflammatory bowel disease (IBD) is under investigation. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and IBD. We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located on chromosome 19p13 and IBD in a Japanese population.


METHODS
We compared 207 Japanese patients who had IBD (79 with Crohn's disease (CD); 128 with ulcerative colitis (UC)) with 103 unrelated Japanese controls. We determined R241G and K469E polymorphisms of the ICAM-1 gene using polymerase chain reaction (PCR) techniques.


RESULTS
Both frequency and carriage rate of the K469 allele were significantly higher in IBD patients than in controls (allelic frequency, p(c)=0.0026; carriage rate, p(c)=0.0034; odds ratio 2.59; 95% confidence interval 1.42-4.68). Furthermore, the frequency of the K469 allele was significantly increased in both CD and UC. Subgroup analysis demonstrated that both K469 allelic frequency and K469 carriage rate were significantly higher in patients with the small bowel and colon type of CD and entire colitis compared with healthy controls.


CONCLUSIONS
We identified an overall association between IBD and ICAM-1 K469 in a Japanese population. Further studies of this chromosome region are required to elucidate the gene responsible for IBD.
Matsuzawa
J
J
Division of Bio-systemic Gastroenterology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan. junmatz@coral.ocn.ne.jp
Sugimura
K
K
Matsuda
Y
Y
Takazoe
M
M
Ishizuka
K
K
Mochizuki
T
T
Seki
S S
SS
Yoneyama
O
O
Bannnai
H
H
Suzuki
K
K
Honma
T
T
Asakura
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002888:Chromosomes, Human, Pair 19; D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged
D018799:Intercellular Adhesion Molecule-1