[Epididymal sperm protein P34H and male reproduction].
During epididymal transit, mammalian spermatozoa acquire new surface proteins that are necessary for gamete interaction. P34H, a member of the short-chain dehydrogenase/reductase(SDR) superfamily, is acquired on the acrosomal cap of human spermatozoon during its maturation arising within epididymis. P34H has been shown to be involved in sperm-zona pellucida interaction. Research revealed that the occurrence of low concentration of sperm protein P34H were significant amongst the idiopathic infertile male population and P34H protein could also be considered as a marker of epididymal sperm maturation in human. Therefore the level of sperm protein P34H is proposed to be a auxiliary diagnostic tool for male infertility. This paper reviews the molecular properties and regulation of the expression of P34H and its association with male reproduction.
Xia
Xin-Yi
XY
Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu, China.
Huang
Yu-Feng
YF
Xu
Xiao-Feng
XF
D042964:Acyl-CoA Dehydrogenase; D044943:Fatty Acid Desaturases / Q000737:chemistry; D015870:Gene Expression; D006801:Humans; D008297:Male; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D013079:Sperm Maturation / Q000502:physiology*; D013401:Sugar Alcohol Dehydrogenases
D011506:Proteins; D013401:Sugar Alcohol Dehydrogenases; C023300:L-xylulose reductase; D044943:Fatty Acid Desaturases; D042964:Acyl-CoA Dehydrogenase