Acyl-lithiation of olefins: formation of cyclopentenones from 1-lithio-butadienes and CO.
[reaction: see text] Intramolecular acyl-lithiation of C=C double bonds proceeds following carbonylation of 1-lithio-1,3-dienes with CO to afford 2- or 3-cyclopentenone derivatives in good to excellent yields after hydrolysis. Addition of electrophiles to the carbonylation reaction mixtures affords various multiply substituted cyclopentenones.
Song
Qiuling
Q
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Li
Zhiping
Z
Chen
Jinglong
J
Wang
Congyang
C
Xi
Zhenfeng
Z