title: Vulvar carcinoma presenting during pregnancy, associated with recurrent bone marrow hypoplasia: a case report and literature review.
abstract: BACKGROUND
  Carcinoma of the vulva has predominantly been a disease of the elderly. Although occasionally it occurs in women under the age of 40 years, carcinoma of the vulva has been rarely diagnosed in pregnancy. Bone marrow hypoplasia can occur as a transient, pregnancy-related event; however, the recurrence of this pathology in future pregnancies is quite rare in the literature.
  
  
  METHODS
  A 29-year-old woman in her second pregnancy that was complicated by bone marrow hypoplasia had developed a squamous vulvar carcinoma. Each of these two conditions are quite rare in pregnancy, they may have occurred by chance, but there is a hypothetical possibility that bone marrow hypoplasia is an autoimmune disorder, with vulvar carcinoma occurring as a further complication in this immunoimpaired individual.
  
  
  CONCLUSIONS
  This case also emphasizes the need to consider malignancy as a differential diagnosis in vulvar ulcers occurring in young women.
authors.affiliation: Birmingham Women's Health Care NHS Trust, Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, United Kingdom. shagaf@sbakour.freeserve.co.uk
authors.forename: Shagaf H
authors.initials: SH
authors.lastname: Bakour
authors.forename: Henna
authors.initials: H
authors.lastname: Jaleel
authors.forename: Judith B
authors.initials: JB
authors.lastname: Weaver
authors.forename: Sean
authors.initials: S
authors.lastname: Kehoe
authors.forename: Keith W
authors.initials: KW
authors.lastname: Radcliffe
mesh_terms: D000328:Adult; D001855:Bone Marrow Diseases / Q000150:complications / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*