title: Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.
abstract: We present a report of MRI and proton MR spectroscopy (MRS) findings in an adolescent patient with Down syndrome and Crohn disease treated with metronidazole. MRI revealed signal abnormalities within the corpus callosum, basal ganglia, and brainstem. Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.
authors.affiliation: Department of Radiology/MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. cecil@athena.chmcc.org
authors.forename: Kim M
authors.initials: KM
authors.lastname: Cecil
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Halsted
authors.forename: Mark
authors.initials: M
authors.lastname: Schapiro
authors.forename: Argirios
authors.initials: A
authors.lastname: Dinopoulos
authors.forename: Blaise V
authors.initials: BV
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001479:Basal Ganglia / Q000473:pathology*; D001923:Brain Chemistry; D001933:Brain Stem / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D003424:Crohn Disease / Q000188:drug therapy*; D004314:Down Syndrome; D006801:Humans; D019344:Lactic Acid / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D019344:Lactic Acid