[Studies on xenogenic acellular dermal matrix as a filling material].
OBJECTIVE
To explore the biological reaction of swine acellular dermal matrix as a filling material for body surface deformity.


METHODS
Xenogenic acellular dermal matrix was implanted into the hypoderm of rabbits. The implants were measured and observed with pathological and transmission electron microscopic technique at regular times. The results were compared with implantation of autologous dermis and swine dermis.


RESULTS
The implanted xenogenic acellular dermal matrix and autologous dermis had slight inflammatory reaction. At 2 weeks there were fibroblasts and capillaries in the implants. The absorptivity of the xenogenic acellular dermal matrix was lower than the swine dermis. The xenogenic acellular dermal matrix was used in 2 clinical cases and obtained good result.


CONCLUSIONS
The xenogenic acellular dermal matrix is an ideal material with good compatibility feature and low absorptivity.
Zhang
Mingli
M
Department of Plastic Surgery, Shanghai Hospital, Second Military Medical University, Shanghai 200433, China.
Wang
Ying
Y
Wang
Dawei
D
Pan
Yingen
Y
Chen
Jiangping
J
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D002971:Cleft Lip / Q000601:surgery; D020405:Dermis / Q000502:physiology / Q000637:transplantation* / Q000648:ultrastructure; D005260:Female; D005542:Forearm / Q000002:abnormalities / Q000601:surgery; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D016038:Skin Transplantation / Q000379:methods; D040521:Subcutaneous Tissue / Q000601:surgery*; D013552:Swine; D014183:Transplantation, Heterologous
D001672:Biocompatible Materials