title: Expression of neuropeptides and cytokines at the extensor carpi radialis brevis muscle origin.
abstract: To reveal whether neuropeptides and cytokines affect the pathogenesis of tennis elbow, expressions of substance P, calcitonin gene-related peptide, interleukin 1 alpha, and transforming growth factor beta1 at the origin of the extensor carpi radialis brevis muscle were investigated in patients with tennis elbow (n = 10). Innervation in the origin was determined with use of the protein gene product 9.5. Substance P-like immunoreactivity and calcitonin gene-related peptide-like immunoreactivity were observed in the nerve fibers around small vessels without apparent infiltration of inflammatory cells. Cells showing positive interleukin 1 alpha or transforming growth factor beta1 immunoreactivity were noted in small vessels and the dense collagen meshwork in 5 of 10 cases. The results suggested that these neuropeptides and cytokines might promote inflammation and stimulate proliferation and matrix synthesis of fibroblasts, contributing to the pathology of tennis elbow.
authors.affiliation: Department of Orthopaedics, Shimane Medical University, Izumo, Japan. uchio@shimane-med.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uchio
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
authors.forename: Koji
authors.initials: K
authors.lastname: Ryoke
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sakai
authors.forename: Youhei
authors.initials: Y
authors.lastname: Ito
authors.forename: Suguru
authors.initials: S
authors.lastname: Kuwata
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D016207:Cytokines / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009479:Neuropeptides / Q000032:analysis / Q000378:metabolism*; D010147:Pain Measurement; D011336:Probability; D011379:Prognosis; D016059:Range of Motion, Articular / Q000502:physiology; D012044:Regression Analysis; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D013373:Substance P / Q000032:analysis / Q000378:metabolism*; D013716:Tennis Elbow / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D009479:Neuropeptides; D013373:Substance P