Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism.
beta-adrenergic receptors (betaARs) are important in determining vascular tone. Stimulation of beta(2)ARs in the vasculature produces vasodilatation, which acts to counteract the vasoconstriction produced by endogenous sympathetic agonists. Impaired vasodilatation occurs in human hypertension and in Blacks. It is now clear that receptor polymorphism may contribute to some of the variability seen in vascular response. beta(2)AR haplotypes determine the desensitization response to chronic agonist exposure in vivo and result in altered vasodilatory responses.
Wood
Alastair J j
AJ
Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA. alastair.wood@vanderbilt.edu
D001808:Blood Vessels / Q000502:physiology; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000502:physiology*; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D014664:Vasodilation / Q000502:physiology; D014666:Vasomotor System / Q000502:physiology
D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2