Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization.
OBJECTIVE
To examine whether gray and white matter volumes are preferentially reduced and cerebral spinal fluid (CSF) increased with starvation in patients with anorexia nervosa compared with healthy controls and to determine what changes occur with weight normalization.


METHODS
Whole intracranial volumes of patients and controls were segmented into gray matter, white matter, and CSF volumes and results compared. A subgroup of patients were rescanned after weight normalization.


RESULTS
Total white matter and several regional white matter volumes were significantly reduced and total and regional CSF volumes were significantly increased in patients versus controls whereas gray matter was not significantly reduced. Total and regional CSF volumes were significantly decreased in patients upon weight normalization whereas white and gray matter volumes increased.


CONCLUSIONS
These changes in brain tissue may be related to a variety of pathophysiologic mechanisms. We hypothesize that insulin-like growth factor-1 may be involved.
Swayze
Victor W
VW
Department of Psychiatry, The University of Iowa Hospitals and Clinics, College of Medicine, Iowa City, Iowa 52246-2208, USA. victor-swayze@uiowa.edu
Andersen
Arnold E
AE
Andreasen
Nancy C
NC
Arndt
Stephan
S
Sato
Yutaka
Y
Ziebell
Steve
S
D000328:Adult; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000473:pathology / Q000628:therapy*; D015992:Body Mass Index; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D003289:Convalescence; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D013997:Time Factors
D007334:Insulin-Like Growth Factor I