Evaluation of free and peptide bound collagen crosslink excretion in different skeletal diseases.
OBJECTIVE
To investigate urinary fractions of free and peptide forms of collagen crosslinks in patients with rheumatoid arthritis (n=50), osteoarthrosis (n=38), psoriatic arthritis (n=38) and in healthy volunteers (33 adults, 17 children).


METHODS
Pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high performance liquid chromatography.


RESULTS
In rheumatoid arthritis (RA) all fractions of PYD and DPD were significantly raised compared with osteoarthritis, psoriatic arthritis, and healthy controls. PYD and DPD correlated with disease activity in RA. In RA the collagen degradation resulted in primarily peptide bound forms.


CONCLUSIONS
The correlation between total peptide bound or free collagen crosslinks in different chronic joint diseases varies; however, this variation does not allow for a reliable differentiation between inflammatory and degenerative joint diseases.
Müller
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Department of Internal Medicine IV, Rheumatology and Osteology, University of Jena, 07740 Jena, Germany. i5admu@med.uni-jena.de
Jakob
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K
Hein
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GE
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000652:urine*; D001168:Arthritis / Q000652:urine*; D015535:Arthritis, Psoriatic / Q000652:urine; D001172:Arthritis, Rheumatoid / Q000652:urine; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D002648:Child; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000652:urine; D018709:Statistics, Nonparametric
D000596:Amino Acids; D015415:Biomarkers; C015484:pyridinoline; C036020:deoxypyridinoline