The application of multi-component reactions in drug discovery.
Multi-component reactions (MCRs) enable the facile, automated and high throughput generation of small organic molecules. MCRs have been used to create diversity oriented and biased combinatorial libraries, to accomplish the synthesis of highly complex natural products as well as for the large-scale production of drug candidates. This provides medicinal chemists with a powerful tool to create novel chemical diversity, matching the space of biological targets with relevant chemistry. The discovery of novel MCRs has become an increasingly active area of research, yielding novel chemical scaffolds for drug discovery efforts.
Weber
Lutz
L
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. lutz.weber@morphochem.de
D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D001685:Biological Factors; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations