Reversible panhypogammaglobulinemia associated with phenytoin treatment.
We report the case of a 24-y-old woman who presented with repeated episodes of otitis due to panhypogammaglobulinemia and low levels of mature CD19 + B cells (84 cells/microl) associated with phenytoin treatment. Lymphocyte subpopulations and immunoglobulin levels need to be monitored if symptoms indicating immunodeficiency occur after the initiation of this treatment.
Pereira
Luis F
LF
Laboratorio de Inmunologia, Hospital San Pedro de Alcantara, Cáceres, Spain. 927230289@telefonica.net
Sanchez
Juan F
JF
D000328:Adult; D000361:Agammaglobulinemia / Q000139:chemically induced* / Q000503:physiopathology; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D010033:Otitis Media / Q000209:etiology / Q000503:physiopathology; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index
D000927:Anticonvulsants; D007070:Immunoglobulin A; D010672:Phenytoin