title: Primary B-cell lymphoma of the clivus: case report.
abstract: BACKGROUND
  Lymphomas usually present in extranodal sites late in the course of the disease. Moreover, it is uncommon for a primary non-Hodgkin's lymphoma to present with cranial nerve palsies; reports in the literature are rare.
  
  
  METHODS
  We report the case of a 60-year-old woman with complaints of headache and double vision. MRI revealed an expansive clival lesion without pituitary invasion. An endoscopic transsphenoidal procedure was performed for diagnosis and partial resection of the mass.
  
  
  CONCLUSIONS
  Primary diffuse large B-cell lymphoma of the clivus is rare. An endoscopic transsphenoidal approach to the skull base is described, along with characteristic clinical, radiologic, and pathologic findings of the lesions.
authors.affiliation: Southern Illinois University School of Medicine, Springfield, Illinois, USA.
authors.forename: Veling W
authors.initials: VW
authors.lastname: Tsai
authors.forename: Leonard
authors.initials: L
authors.lastname: Rybak
authors.forename: Jose
authors.initials: J
authors.lastname: Espinosa
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Kuhn
authors.forename: Onsi W
authors.initials: OW
authors.lastname: Kamel
authors.forename: Frances
authors.initials: F
authors.lastname: Mathews
authors.forename: F Robert
authors.initials: FR
authors.lastname: Glatz
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor