Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether-poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry.
The newly developed stable DMEPHF (1/15) complex was found to be a highly effective reagent for the cleavage of peptides from Merrifield resins; ease of handling and its simple, complete removal from the reaction mixture make the reagent system a very useful HF equivalent for applications in solid-phase peptide synthesis.
Török
Béla
B
Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA.
Bucsi
Imre
I
Prakash
G K Surya
GK
Olah
George A
GA
D020650:Combinatorial Chemistry Techniques; D005563:Formic Acid Esters; D006858:Hydrofluoric Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D006868:Hydrolysis; D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis*; D012117:Resins, Synthetic / Q000737:chemistry
D005563:Formic Acid Esters; D007202:Indicators and Reagents; D010455:Peptides; D012117:Resins, Synthetic; C476506:dimethyl ether-poly(hydrogen fluoride); C000345:t-butyloxycarbonyl group; D006858:Hydrofluoric Acid