title: Development and evaluation of a nano-electrospray ionisation source for atmospheric pressure ion mobility spectrometry.
abstract: A nano-electrospray ionisation source has been designed and constructed for a high temperature ion mobility spectrometer. The drift cell was modified by replacement of the 63Ni atmospheric pressure chemical ionisation source with a tube lens/desolvation region and operated using commercial nano-electrospray capillaries. Ions were introduced into the drift region via a Bradbury-Nielson gate (pulse width 50 micros, repetition period 20 ms). A unidirectional flow of nitrogen was used as the drift gas at temperatures in the range 100-150 degrees C to aid desolvation. The performance of the nano-electrospray ion source has been demonstrated for analytes including crown ethers, amino acids and peptides. Reduced mobilities determined by nano-ESI were consistent with those reported using a 63Ni ion source.
authors.affiliation: Department of Chemistry and Physics, Nottingham Trent University, UK.
authors.forename: Claire J
authors.initials: CJ
authors.lastname: Bramwell
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Colgrave
authors.forename: Colin S
authors.initials: CS
authors.lastname: Creaser
authors.forename: Richard
authors.initials: R
authors.lastname: Dennis
mesh_terms: D000596:Amino Acids / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D009842:Oligopeptides / Q000032:analysis; D011506:Proteins / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000596:Amino Acids; D009842:Oligopeptides; D011506:Proteins