Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin: a case report.
We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily plasmapheresis and steroids but readily and completely responsive to docetaxel plus cisplatin. Sustained and complete response was pathologically confirmed.
Marcoullis
George
G
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, 600 East 233 Street, Bronx 10466, NY, USA. gmarcoullis@olmhs.org
Abebe
Lool
L
Jain
Dharamvir
D
Talusan
Richard
R
Bhagwati
Niyati
N
Wiernik
Peter H
PH
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000743:Anemia, Hemolytic / Q000209:etiology / Q000628:therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D000077143:Docetaxel; D005260:Female; D006461:Hemolysis; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D010956:Plasmapheresis; D043823:Taxoids
D000894:Anti-Inflammatory Agents, Non-Steroidal; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel; D002945:Cisplatin; D008775:Methylprednisolone