title: CT during arterial portography: effects of precontrast injection of prostaglandin E1 into the superior mesenteric artery.
abstract: Prostaglandin E1 (PGE1) is a vasodilator that increases portal venous flow. Hepatic CT during arterial portography (CTAP) was performed in 42 patients with and without PGE1 to compare peak hepatic enhancement and nontumorous abnormalities. Although no significant differences in peak hepatic enhancement were observed (71 +/- 12 HU for CTAP with PGE1; 74 +/- 34 HU for CTAP without PGE1), the number of nontumorous abnormalities for CTAP with PGE1 (n = 11) was significantly lower than that for CTAP without PGE1 (n = 24) (p < 0.01, Wilcoxon signed rank test). CTAP combined with PGE1 therefore represents a useful method to study lesions of the liver, as the number of nontumorous abnormalities observed is significantly reduced and liver parenchyma can be scanned more evenly.
authors.affiliation: Department of Radiology, Wakayama Medical University, 811-1 Kimiidera Wakayama 641-8510, Japan. mterada@wakayama-med.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Terada
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Tanihata
authors.forename: Koushi
authors.initials: K
authors.lastname: Horihata
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Masuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Kimura
authors.forename: Motoki
authors.initials: M
authors.lastname: Nakai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Shirai
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011172:Portography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil