title: Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array.
abstract: By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.
authors.affiliation: Division of Surgical Oncology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kokuryo
authors.forename: Tatsuyoshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Oda
authors.forename: Junichi
authors.initials: J
authors.lastname: Kamiya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Senga
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohno
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: Miin-Fu
authors.initials: MF
authors.lastname: Chen
authors.forename: Yi-Yin
authors.initials: YY
authors.lastname: Jan
authors.forename: Ta-Sen
authors.initials: TS
authors.lastname: Yeh
authors.forename: Cheng-Taug
authors.initials: CT
authors.lastname: Chiu
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Hsieh
authors.forename: Michinari
authors.initials: M
authors.lastname: Hamaguchi
mesh_terms: D002137:Calculi / Q000150:complications / Q000235:genetics*; D018281:Cholangiocarcinoma / Q000209:etiology; D004249:DNA Damage; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000150:complications / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011519:Proto-Oncogenes