title: Molecular strategies in Metazoan genomic evolution.
abstract: During the evolution of Metazoa, the mitochondrial genome has remained practically unchanged as indicated by its small size and constant gene content in each lineage, although several evolutionary processes have taken place. In contrast, the nuclear genome of Metazoa has undergone dramatic changes, as is demonstrated by some entire genomes completely sequenced so far. The expansion of gene families and the appearance of new functions and new regulatory circuits are among the most prominent features. Here, we report a description of the evolution of the p53 gene family as an example of expansion of both genetic complexity and gene expression of the nuclear genome.
authors.affiliation: Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi, via Orabona 4, Bari, Italy. saccone@area.ba.cnr.it
authors.forename: Cecilia
authors.initials: C
authors.lastname: Saccone
authors.forename: Pierre Olivier
authors.initials: PO
authors.lastname: Barome
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: D'Erchia
authors.forename: Ilenia
authors.initials: I
authors.lastname: D'Errico
authors.forename: Graziano
authors.initials: G
authors.lastname: Pesole
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Sbisà
authors.forename: Apollonia
authors.initials: A
authors.lastname: Tullo
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D019143:Evolution, Molecular; D005796:Genes / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016678:Genome; D006801:Humans; D008565:Membrane Proteins; D009687:Nuclear Proteins / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D025521:Tumor Suppressor Proteins
chemical_list: C081876:CKAP4 protein, human; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins