Highly enantioselective hydrogenation of enol acetates catalyzed by Ru-TunaPhos complexes.
[reaction: see text] The chiral disphosphines with tunable dihedral angles (TunaPhos) have been used for asymmetric hydrogenation of enol acetates and dihedral-angle-dependent enantioselectivities were observed. C2-TunaPhos has been proved to be effective for Ru-catalyzed asymmetric hydrogenation of electron-deficient and other enol acetates.
Wu
Shulin
S
Department of Chemistry, The Pennsylvania State University, 152 Davey Laboratory, University Park 16802, USA.
Wang
Weimin
W
Tang
Wenjun
W
Lin
Min
M
Zhang
Xumu
X
D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D008968:Molecular Conformation; D015394:Molecular Structure; D012413:Rubidium / Q000737:chemistry*
D000085:Acetates; D008024:Ligands; D012413:Rubidium