title: Current trends in the treatment of upper gastrointestinal disease.
abstract: The past 25 years have seen an amazing improvement in the treatment and understanding of acid-related disorders. In particular, the introduction of selective histamine receptor antagonists and proton pump inhibitors has made the medical control of acid secretion an effective means of therapy. The demonstration that infection with Helicobacter pylori is responsible for most cases of peptic ulcer disease resulted in another major improvement in therapy in these areas as a result of the eradication of the organism. Research continues in an attempt to find improved means of acid control and better methods for the eradication of H. pylori based on unique proteins expressed by the organism to resist gastric acidity.
authors.affiliation: Geffen School of Medicine at UCLA and GWLA Health Center, Los Angeles, USA.
authors.forename: George
authors.initials: G
authors.lastname: Sachs
authors.forename: Jai Moo
authors.initials: JM
authors.lastname: Shin
authors.forename: Olga
authors.initials: O
authors.lastname: Vagin
authors.forename: Keith
authors.initials: K
authors.lastname: Munson
authors.forename: David
authors.initials: D
authors.lastname: Weeks
authors.forename: David R
authors.initials: DR
authors.lastname: Scott
authors.forename: Petra
authors.initials: P
authors.lastname: Voland
mesh_terms: D000863:Antacids / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D005770:Gastrointestinal Neoplasms / Q000517:prevention & control; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D054328:Proton Pump Inhibitors
chemical_list: D000863:Antacids; D054328:Proton Pump Inhibitors