Phytochemical compounds involved in the anti-inflammatory effect of propolis extract.
Two ethanolic propolis extracts (EPE) with and without the caffeic acid phenethyl ester (CAPE), CAPE and galangin (major components of propolis) were investigated for anti-inflammatory activity in rats using carrageenin foot oedema, carrageenin pleurisy and adjuvant arthritis. In our experiments, EPE with CAPE and CAPE alone significantly inhibited carrageenin oedema, carrageenin pleurisy and adjuvant arthritis. In contrast EPE without CAPE and galangin did not exhibit anti-inflammatory effects in acute and chronic inflammation. These results suggest that the anti-inflammatory activity of propolis is due to CAPE.
Borrelli
F
F
Department of Experimental Pharmacology, University of Naples 'Federico II', Via D. Montesano 49, 80131, Naples, Italy.
Maffia
P
P
Pinto
L
L
Ianaro
A
A
Russo
A
A
Capasso
F
F
Ialenti
A
A
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced / Q000517:prevention & control*; D002109:Caffeic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control*; D011429:Propolis / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D002109:Caffeic Acids; D005419:Flavonoids; D010936:Plant Extracts; C037032:galangin; D002351:Carrageenan; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol