Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival.
Boutillier
Anne-Laurence
AL
Laboratoire de Signalisations Moléculaires et Neurodégénérescence EA 3433, Faculté de Médecine, 67085 Strasbourg Cedex, France. laurette@neurochem.u-strasbg.fr
Trinh
Emmanuelle
E
Loeffler
Jean-Philippe
JP
D000818:Animals; D018797:Cell Cycle Proteins; D002470:Cell Survival / Q000502:physiology*; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017930:Genes, Reporter; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008156:Luciferases / Q000235:genetics; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; C493754:E2f1 protein, mouse; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D014157:Transcription Factors; C012589:trichostatin A; D008156:Luciferases; D006655:Histone Deacetylases