Homocysteine and arterial disease. Experimental mechanisms.
Hyperhomocysteinemia (hH(e)) in the general population is associated with incidence and progression of arterial occlusive disease, although the underlying mechanisms are not well defined. Current research supports a role for homocysteine (H(e))-mediated endothelial damage and endothelial dysfunction. This mechanism appears to be a key factor in subsequent impaired endothelial-dependent vasoreactivity and decreased endothelium thromboresistance. These consequences may predispose hyperhomocysteinemic vessels to the development of increased atherogenesis. Additional mechanisms of H(e)-mediated vascular pathology, including protein homocysteinylation and vascular smooth muscle cell proliferation may also play a role. Continued investigation into the mechanisms contributing to H(e) toxicity will provide further insight into the processes by which hH(e) may increase atherosclerosis.
Cook
Judith W
JW
Division of Vascular Surgery, Oregon Health and Sciences University, Portland, OR, USA.
Taylor
Lloyd M
LM
Orloff
Susan L
SL
Landry
Gregory J
GJ
Moneta
Gregory L
GL
Porter
John M
JM
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D006710:Homocysteine / Q000097:blood / Q000378:metabolism*; D006801:Humans
D006710:Homocysteine