[Practicability study on a group of vigilant chemical compounds including chlorheridine diacetate].
OBJECTIVE
To test in vitro the spermatozocidine drug which can also prevent sex transmitting diseases (STD) pathogens.


METHODS
Chlorheridine diacetate and other three chemical compounds were applied in vitro spermatozocidine and sperm inhibitting tests.


RESULTS
The lowest concentrations of chlorheridine diacetate and p-nitrophenol which can inhibit human sperm in 20 seconds were 1.25 mg/ml. The minimal inhibitory concentration and minimal bactericidal concentration of chlorheridine diacetate and p-nitrophenol on Streptococcus albus Stemberg were 0.125 to 0.50 mg/ml and 0.25 to 1.00 mg/ml.


CONCLUSIONS
Chlorheridine diacetate and p-uitrophenol have strong spermatozocidine and antibacteria effects.
Fu
Xiao-Min
XM
Family Planning Research Institute, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310013, China.
Jin
Ai-Hua
AH
Zou
Jian
J
Li
Qian-Li
QL
D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D009596:Nitrophenols / Q000494:pharmacology / Q000627:therapeutic use; D012749:Sexually Transmitted Diseases / Q000517:prevention & control; D013089:Spermatocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013094:Spermatozoa / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects
D000085:Acetates; D000900:Anti-Bacterial Agents; D009596:Nitrophenols; D013089:Spermatocidal Agents; C469946:chlorheridine diacetate; C024836:4-nitrophenol