Primary CD56+ T/NK cell lymphoma of the colon.
Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel diseases such an Crohn's colitis, and most physicians have little available information on this group of neoplasms. Moreover, florid nonspecific inflammatory infiltrates would not allow characterization of the tumor cells in such an inflammatory background. Herein, we describe a patient who initially presented with features that were clinically and colonoscopically similar to Crohn's colitis. Three months later, he had cecal bleeding and perforation, and primary T/NK cell lymphoma of the colon was diagnosed through immunophenotypic and genotypic studies of surgical specimens.
Kim
Hyun Soo
HS
Division of Gastroenterology, Department of Internal Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, 162 Ilsan-Dong, Wonju 220-701, Republic of Korea.
Lee
Dong Ki
DK
Baik
Soon Koo
SK
Kwon
Sang Ok
SO
Cho
Mee Yon
MY
Ko
Young Hye
YH
D000328:Adult; D019002:CD56 Antigen / Q000032:analysis*; D003092:Colitis / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D003110:Colonic Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D003113:Colonoscopy; D003424:Crohn Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D008297:Male
D019002:CD56 Antigen