UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.
[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.
Agatsuma
Tsutomu
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida, Japan. tsutomu.agatsuma@kyowa.co.jp
Akama
Tsutomu
T
Nara
Shinji
S
Matsumiya
Shigeki
S
Nakai
Ryuichiro
R
Ogawa
Harumi
H
Otaki
Shizuo
S
Ikeda
Shun-Ichi
S
Saitoh
Yutaka
Y
Kanda
Yutaka
Y
D000164:Acremonium / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D018360:Crystallography, X-Ray; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids; C409195:UCS 1025A; C470811:UCS1025B