title: Rates of behavior and aging specified by mitochondrial function during development.
abstract: To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dillin
authors.forename: Ao-Lin
authors.initials: AL
authors.lastname: Hsu
authors.forename: Nuno
authors.initials: N
authors.lastname: Arantes-Oliveira
authors.forename: Joshua
authors.initials: J
authors.lastname: Lehrer-Graiwer
authors.forename: Honor
authors.initials: H
authors.lastname: Hsin
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Fraser
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Kamath
authors.forename: Julie
authors.initials: J
authors.lastname: Ahringer
authors.forename: Cynthia
authors.initials: C
authors.lastname: Kenyon
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D017173:Caenorhabditis elegans / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D048429:Cell Size; D004579:Electron Transport; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III / Q000235:genetics / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D004722:Endoribonucleases / Q000235:genetics / Q000378:metabolism; D005247:Feeding Behavior; D051858:Forkhead Transcription Factors; D007506:Iron-Sulfur Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity; D008928:Mitochondria / Q000378:metabolism*; D025261:Mitochondrial Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism; D009068:Movement; D009245:NADH Dehydrogenase / Q000235:genetics / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics / Q000378:metabolism; D010101:Oxygen Consumption; D010641:Phenotype; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism; D043244:Ribonuclease III; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D007506:Iron-Sulfur Proteins; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; C443102:Isp-1 protein, Caenorhabditis elegans; D009247:NADH, NADPH Oxidoreductases; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin; D004722:Endoribonucleases; D043244:Ribonuclease III; D025261:Mitochondrial Proton-Translocating ATPases; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III