title: Getting to the heart of a splicing enhancer.
abstract: Dinucleotide CA repeats of variable length in an intron of the human endothelial nitric oxide synthase gene act as regulatory signals for splicing of the gene's pre-mRNA. Repeat length-dependent binding of hnRNP L to the repeats provides an intriguing link between splicing efficiency, nitric oxide synthesis and cardiovascular disease.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bilbao
authors.forename: Juan
authors.initials: J
authors.lastname: Valcárcel
mesh_terms: D018900:Dinucleotide Repeats / Q000235:genetics*; D034664:Heterogeneous-Nuclear Ribonucleoprotein L / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007438:Introns / Q000235:genetics; D008954:Models, Biological; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011485:Protein Binding; D012326:RNA Splicing
chemical_list: D034664:Heterogeneous-Nuclear Ribonucleoprotein L; D052250:Nitric Oxide Synthase Type III