title: Synthesis and antifungal activity of 2,5-disubstituted-6-arylamino-4,7-benzimidazolediones.
abstract: 2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Among them, 6-arylamino-5-chloro-2-(2-pyridyl)-4,7-benzimidazolediones exhibited potent antifungal activity against Candida species and Aspergillus niger.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: -Ryu
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Song
authors.forename: Ju-Yeon
authors.initials: JY
authors.lastname: Shim
authors.forename: Hea-Jung
authors.initials: HJ
authors.lastname: You
authors.forename: Ko Un
authors.initials: KU
authors.lastname: Choi
authors.forename: Ik Hwa
authors.initials: IH
authors.lastname: Choi
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Chae
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D001562:Benzimidazoles