Transformations of testosterone and related steroids by Botrytis cinerea.
Botrytis cinerea (strain AM235) was used to investigate the transformations of testosterone and related steroids. It was found that the position and stereochemistry of the introduced hydroxyl group, as well as the yield of products, depended on the structure of the substrate. Botrytis cinerea converts the examined substrates mainly to 7 alpha-hydroxy derivatives. 1-Dehydrotestosterone was also significantly hydroxylated at a 14 alpha-position.
Huszcza
Ewa
E
Department of Chemistry, Agricultural University, Norwida 25, 50-375 Wroclaw, Poland. huszcza@ozi.ar.wroc.pl
Dmochowska-Gładysz
Jadwiga
J
D001711:Biotransformation; D020171:Botrytis / Q000201:enzymology / Q000378:metabolism*; D002478:Cells, Cultured; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013256:Steroids / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D013256:Steroids; D013739:Testosterone