Cigarette smoke-induced acute eosinophilic pneumonia accompanied with neutrophilia in the blood.
Smoking causes various changes in the lung. This report describes a case of cigarette smoke-induced acute eosinophilic pneumonia (CS-AEP) with neutrophilia in the blood. However, the precise mechanism is unknown, so we examined the effect of exposure to cigarette smoke extracts on the production of interleukin (IL)-4, IL-5, IL-8, IL-18, granulocyte macrophage-colony stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) by human bronchial epithelial cells (HBECs) obtained from the patient. We found that IL-8 released from HBECs was involved in neutrophilia in the blood, and is a new factor in the development of AEP, especially in the early phase.
Miki
Keisuke
K
Department of Internal Medicine, JA Kochi Hospital, Nankoku, Kochi.
Miki
Mari
M
Okano
Yoshio
Y
Nakamura
Yoichi
Y
Ogushi
Fumitaka
F
Ohtsuki
Yuji
Y
Nakayama
Takuro
T
D000208:Acute Disease; D000293:Adolescent; D005260:Female; D006801:Humans; D009504:Neutrophils; D011657:Pulmonary Eosinophilia / Q000097:blood / Q000209:etiology*; D012907:Smoking / Q000009:adverse effects* / Q000097:blood