title: Osteopenia in patients infected by the human immunodeficiency virus. A case control study.
abstract: Summary - In the last few years, the use of highly active antiretroviral therapy has radically modified the prognosis of human immunodeficiency virus (HIV) infection. Osteonecrosis and osteoporosis are among the bone complications recently described in HIV-infected patients. We report a preliminary study comparing 47 HIV-infected patients (31 men and 16 women) to 47 age- and sex-matched controls. Bone mineral density was lower in patients than in controls: in men, 0.919 +/- 0.120 g/cm2 vs. 1.010 +/- 0.139 g/cm2 (P = 0.01) at the total hip and 0.948 +/- 0.100 g/cm2 vs. 1.043 +/- 0.117 g/cm2 (P = 0.0008) at the lumbar spine; in women, 0.912 +/- 0.149 g/cm2 vs. 0.968 +/- 0.090 g/cm2 at the total hip (P = 0.17) and 0.989 +/- 0.152 g/cm2 vs. 1.080 +/- 0.097 g/cm2 (P = 0.01) at the lumbar spine. HIV-infected males were more likely to have osteopenia and osteoporosis, as compared to the male controls (19 vs. 14 and 4 vs. 1, respectively, P = 0.02). None of the women had osteoporosis; nine HIV-infected women and one female control had osteopenia (P = 0.003). No fractures were recorded. In this preliminary study, no evidence supporting a relationship between bone loss and protease inhibitor treatment was found.
authors.affiliation: Institut do Prévention et de Recherche sur l'Ostéoporose, Equipe INSERM-ERIT M 0101, Hĵpital Porte Madeleine BP 2439 45032 Orléans Cedex, France. ipros@wanadoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Loiseau-Pérès
authors.forename: C
authors.initials: C
authors.lastname: Delaunay
authors.forename: S
authors.initials: S
authors.lastname: Poupon
authors.forename: E
authors.initials: E
authors.lastname: Lespessailles
authors.forename: N
authors.initials: N
authors.lastname: Ballouche
authors.forename: P
authors.initials: P
authors.lastname: Arsac
authors.forename: C L
authors.initials: CL
authors.lastname: Benhamou
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology
chemical_list: D019380:Anti-HIV Agents