Acute renal failure in IgA nephropathy: aggravation by gross hematuria due to anticoagulant treatment.
IgA nephropathy is one of the most common forms of glomerulonephritis. Macroscopic or microscopic hematuria with mild proteinuria are the main symptoms. Without complicating factors, IgA nephropathy has a favourable long-term prognosis. We report a case of reversible acute renal failure (ARF) as a complication of mild IgA nephropathy while oral anticoagulants were administered. Diagnosis was based on a renal biopsy showing marked granular mesangial IgA-deposition. In addition, numerous tubules were extended and completely obstructed by red blood cell casts. After hemodialysis treatment and parallel anti-inflammatory steroids and after stopping anticoagulation, renal function gradually improved up to complete remission. This report indicates that anticoagulatory treatment may have negative effects on the long-term prognosis of IgA nephropathy with respect to development of ARF or tubulo-interstitial inflammation.
August
Christian
C
Gerhard-Domagk Institute of Pathology, University of Münster, Germany.
Atzeni
Andreas
A
Köster
Ludger
L
Heidenreich
Stefan
S
Lang
Detlef
D
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000473:pathology*; D006417:Hematuria / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy*
D000925:Anticoagulants