Body fat accumulation is greater in rats fed a beef tallow diet than in rats fed a safflower or soybean oil diet.
The effects of dietary fats , consisting of different fatty acids, on body fat accumulation and uncoupling protein (UCP) in interscapular brown adipose tissue were studied in rats. Metabolisable energy in experimental diets based on safflower oil, soybean oil or beef tallow was measured strictly (experiment 1). Male Wistar rats were then meal-fed an isoenergetic diet for 8 weeks (experiment 2). Each group of rats showed the same weight gain during the 8-week experimental period. Carcass fat content was greater in rats fed the beef tallow diet than in those fed the with the safflower or soybean oil diets, whereas the weight of abdominal adipose tissue was the same for all three dietary groups. Gene expression of UCP1 and the UCP content of the interscapular brown adipose tissue was lower in the beef tallow diet group than in the other dietary groups. A negative correlation was observed between carcass fat content and n-6 unsaturated fatty acid content in dietary fats. These results suggest that the greater body fat accumulation in rats fed the beef tallow diet results from lower expression of UCP1 mRNA and lower UCP content in brown adipose tissue. n-6 Polyunsaturated fatty acids may be the most effective fatty acids in limiting body fat.
Matsuo
Tatsuhiro
T
Faculty of Agriculture, Kagawa University, Kagawa, Japan. matsuo@ag.kagawa-u.ac.jp
Takeuchi
Hiroyuki
H
Suzuki
Hiroo
H
Suzuki
Masashige
M
D000273:Adipose Tissue / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001823:Body Composition; D002352:Carrier Proteins / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005223:Fats / Q000008:administration & dosage; D015870:Gene Expression; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins; D051381:Rats; D017208:Rats, Wistar; D012450:Safflower Oil / Q000008:administration & dosage; D013024:Soybean Oil / Q000008:administration & dosage; D000071256:Uncoupling Protein 1; D015430:Weight Gain / Q000187:drug effects*
D002352:Carrier Proteins; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005223:Fats; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C000604373:Ucp1 protein, rat; D000071256:Uncoupling Protein 1; D013024:Soybean Oil; D012450:Safflower Oil; C013698:tallow