title: [Apheresis of immunoglobulins - new approach to the treatment of severe dilated cardiomyopathy].
abstract: Two courses of immunoadsorption with 'Ig Adsopak' were used in the treatment of a patient with dilated cardiomyopathy (DCM) during which all class G and partially class M and A immunoglobulins were removed. Every course consisted of 5 daily procedures and resulted in removal of 98% of immunoglobulins. This was associated with complete removal of autoantibodies to beta1-adrenoreceptor. After the end of a course loss of immunoglobulins was replenished by intravenous infusion of Pentaglobin and Oktagam. Echocardiographic study carried out before, during and after second course of apheresis revealed reduction of left and right ventricular and atrial volumes and dimensions, improvement of contractility of anterior part of interventricular septum and of anterolateral left ventricular wall. As efficacy of drug therapy of dilated cardiomyopathy is low and facilities of cardiac transplantation are limited the method of therapeutic apheresis reveals novel perspectives of the treatment of dilated cardiomyopathies.
authors.forename: G A
authors.initials: GA
authors.lastname: Konovalov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
authors.forename: P V
authors.initials: PV
authors.lastname: Zvezdkin
authors.forename: A N
authors.initials: AN
authors.lastname: Chebyshev
authors.forename: S N
authors.initials: SN
authors.lastname: Semin
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kuznetsova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Adamova
authors.forename: S G
authors.initials: SG
authors.lastname: Kipor
authors.forename: S N
authors.initials: SN
authors.lastname: Pokrovskiĭ
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000628:therapy*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D007136:Immunoglobulins