Stereoselective transformation of indole diazabicyclo[3.2.2]nonedione to azepinoindole.
[reaction: see text] The synthesis of an indole diazabicyclo[3.2.2]nonedione derivative was achieved in a few steps starting from L-tryptophan. Reduction with borane-THF complex leads to fragmentation of the bicycle and the stereoselective formation of an azepinoindole derivative was observed.
Orain
David
D
Novartis Pharma AG, Core Technology, Combinatorial Chemistry Unit, WSJ-507.7.04 Lichtstrasse 35, CH-4056 Basel, Switzerland.
Denay
Régis
R
Koch
Guido
G
Giger
Rudolf
R