title: Unravelling the signal-transduction network in B lymphocytes.
abstract: The Alliance for Cellular Signaling has chosen the mouse B lymphocyte as a model system to understand basic principles that govern cellular signalling. Progress to that end has focused initially on establishing a reproducible experimental cell system and characterizing essential signalling responses. Although unravelling this complex network will take years, findings revealed in the interim will prove immensely useful to the scientific community at large.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA. sambrano@cmp.ucsf.edu
authors.forename: Gilberto R
authors.initials: GR
authors.lastname: Sambrano
authors.forename: Grischa
authors.initials: G
authors.lastname: Chandy
authors.forename: Sangdun
authors.initials: S
authors.lastname: Choi
authors.forename: Dianne
authors.initials: D
authors.lastname: Decamp
authors.forename: Robert
authors.initials: R
authors.lastname: Hsueh
authors.forename: Keng-Mean
authors.initials: KM
authors.lastname: Lin
authors.forename: Dennis
authors.initials: D
authors.lastname: Mock
authors.forename: Nancy
authors.initials: N
authors.lastname: O'Rourke
authors.forename: Tamara
authors.initials: T
authors.lastname: Roach
authors.forename: Hongjun
authors.initials: H
authors.lastname: Shu
authors.forename: Bob
authors.initials: B
authors.lastname: Sinkovits
authors.forename: Mary
authors.initials: M
authors.lastname: Verghese
authors.forename: Henry
authors.initials: H
authors.lastname: Bourne
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D020869:Gene Expression Profiling; D051379:Mice; D008954:Models, Biological; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D011485:Protein Binding; D012106:Research / Q000639:trends; D012107:Research Design; D015398:Signal Transduction
chemical_list: D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate