title: Dynamic multislice helical CT of ameloblastoma and odontogenic keratocyst: correlation between contrast enhancement and angiogenesis.
abstract: OBJECTIVE
  The purpose of this study was to assess whether the enhancement characteristics of dynamic multislice helical CT (MS-CT) could help in the differential diagnosis of ameloblastomas and odontogenic keratocysts. The correlation between enhancement characteristics and immunohistochemical findings, especially with regard to angiogenesis, was also evaluated.
  
  
  METHODS
  Dynamic MS-CT was performed in 13 consecutive patients (8 ameloblastoma cases and 5 odontogenic keratocyst cases). The percentage of density increase (Enh%) was measured in dynamic MS-CT images taken during the arterial phase, and microvessel density (MVD) was analyzed using immunohistochemical study with anti-CD31 antibody. The Mann-Whitney U test was used to evaluate the significance of the Enh% or the MVD values between lesion subtypes, and the Spearman correlation coefficient was used to evaluate the correlation between the Enh% and the MVD in ameloblastomas and odontogenic keratocysts.
  
  
  RESULTS
  The Enh% in ameloblastomas was significantly higher than that of odontogenic keratocysts (P < 0.005). The MVD of ameloblastomas was also significantly higher than that of odontogenic keratocysts (P < 0.005). The Enh% values for ameloblastomas and odontogenic keratocysts were positively correlated with the respective MVD values (r = 0.92, P < or = 0.000).
  
  
  CONCLUSIONS
  Dynamic MS-CT is useful tool for differentiating between ameloblastomas and odontogenic keratocysts on the basis of the contrast enhancement values of intratumoral vascularities during the arterial phase. Furthermore, the Enh% obtained by dynamic MS-CT is correlated with the MVD in ameloblastomas and odontogenic keratocysts.
authors.affiliation: Department of Dentistry, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. katsuh@jikei.ac.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tozaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugisaki
authors.forename: Nahoko
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Fukuda
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Tanabe
mesh_terms: D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009807:Odontogenic Cysts / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*