Solid-phase synthesis of substituted alkynes using the Nicholas reaction.
The first example of a Nicholas reaction on solid phase is reported, involving the reaction of cobalt complexes of polymer-bound alkynols with different nucleophiles in the presence of a Lewis acid, to form carbon-oxygen or carbon-carbon bonds.
Cassel
Johan A
JA
Department of Organic Chemistry, Chalmers University of Technology, SE-412 96 Göteborg, Sweden. nina.kann@oc.chalmers.se
Leue
Stefanie
S
Gachkova
Natalie I
NI
Kann
Nina C
NC