title: A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces.
abstract: The occurrence of poly-3-hydroxybutyric acid (PHB) in 12 different strains of the genus Streptomyces was investigated. Gas chromatographic estimation indicated that all the strains produced PHB and the range of maximum PHB accumulation was between 1.5 and 11.8% dry cell weight. PHB was isolated from Streptomyces coelicolor A3(2) M145 and characterized using Fourier transform-infrared (FT-IR) spectroscopy. The correlation between PHB utilization and antibiotic production in S. coelicolor A3(2) M145, was studied; results indicated a possible role of PHB as a carbon reserve material used for antibiotic production.
authors.affiliation: Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi-110016, India.
authors.forename: Shivani
authors.initials: S
authors.lastname: Verma
authors.forename: Yukti
authors.initials: Y
authors.lastname: Bhatia
authors.forename: Sabeel Padinhara
authors.initials: SP
authors.lastname: Valappil
authors.forename: Ipsita
authors.initials: I
authors.lastname: Roy
mesh_terms: D000880:Anthraquinones / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002849:Chromatography, Gas; D006885:Hydroxybutyrates / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D007783:Lactones / Q000494:pharmacology; D025282:Mycelium / Q000737:chemistry / Q000302:isolation & purification; D011091:Polyesters / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000494:pharmacology; D013223:Statistics as Topic; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors; D000095622:Benzoisochromanequinones; D000094122:Polyhydroxybutyrates
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D006885:Hydroxybutyrates; D007783:Lactones; D011091:Polyesters; D011353:Prodigiosin; C098846:gamma-actinorhodin; D000095622:Benzoisochromanequinones; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C047347:undecylprodigiosin; C013390:actinorhodin