title: Bone involvement in eugonadal male patients with adrenal incidentaloma and subclinical hypercortisolism.
abstract: Adrenal incidentalomas (AI) are not associated, by definition, with clinically evident syndromes; however, some AI patients may show biochemical indexes of subclinical hypercortisolism (SH). Previous data on female AI patients indicated that SH may lead to bone loss, at least at spine. No data are available on bone involvement in samples of only AI male patients. We measured bone metabolism and bone mineral density at spine and femur by dual-energy x-ray absorptiometry in 38 consecutive eugonadal male AI patients and 38 healthy matched control subjects. Patients were subdivided according to the presence or absence of SH (group SH+ and group SH-, respectively). Mean Z-score levels of spinal bone mineral density measured by dual-energy x-ray absorptiometry were lower (P < 0.05) in group SH+ (-0.42 +/- 1.62) in comparison with group SH- (0.6 +/- 1.13) and controls (0.47 +/- 1.06). Thus, in order for the most appropriate management to be individually tailored, bone mass evaluation is strongly indicated in AI male patients with SH, irrespective of their gonadal status.
authors.affiliation: Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (Foggia), Italy.
authors.forename: Iacopo
authors.initials: I
authors.lastname: Chiodini
authors.forename: Libuse
authors.initials: L
authors.lastname: Tauchmanovà
authors.forename: Massimo
authors.initials: M
authors.lastname: Torlontano
authors.forename: Claudia
authors.initials: C
authors.lastname: Battista
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guglielmi
authors.forename: Mario
authors.initials: M
authors.lastname: Cammisa
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carnevale
authors.forename: Riccardo
authors.initials: R
authors.lastname: Rossi
authors.forename: Sergio
authors.initials: S
authors.lastname: Di Lembo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Trischitta
authors.forename: Alfredo
authors.initials: A
authors.lastname: Scillitani
mesh_terms: D015502:Absorptiometry, Photon; D000236:Adenoma / Q000150:complications* / Q000000981:diagnostic imaging*; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging*; D000308:Adrenocortical Hyperfunction / Q000209:etiology*; D000328:Adult; D000368:Aged; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013131:Spine / Q000000981:diagnostic imaging / Q000378:metabolism