title: [A patient with diffuse peritoneal metastases of GIST who was administered STI571].
abstract: We report a patient with diffuse peritoneal metastases of GIST who was administered STI571 (a tyrosine kinase inhibitor). She was a 45-year-old woman who underwent surgery for a mass that was suspected to be an ovarian tumor. The postoperative diagnosis was GIST developing from the small intestine. Two years later, multiple peritoneal metastases were noted and a complete macroscopic resection was done. Six months after the second operation, she needed a third operation and complete macroscopic resection was repeated. Only 4 months after the third operation, she underwent a fourth operation. We resected massive peritoneal metastases, but diffuse metastases remained. Therefore, we started to administer STI571 at 400 mg/day. She has been free from peritoneal masses for 9 months after the fourth operation. We recommend STI571 for uncontrolled diffuse peritoneal metastases of GIST.
authors.affiliation: Dept. of Surgery, Osaka National Hospital.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Mukaide
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Eisei
authors.initials: E
authors.lastname: Shin
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Isamu
authors.initials: I
authors.lastname: Nishisyou
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tujinaka
authors.forename: Kunimitu
authors.initials: K
authors.lastname: Kawahara
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kurata
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D007414:Intestinal Neoplasms / Q000473:pathology; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D004791:Enzyme Inhibitors; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate