The importance of being a myoepithelial cell.
The mammary myoepithelial cell was named the 'Cinderella of mammary cell biology' in light of the earlier focus on the luminal cell. Mammary myoepithelial cells have recently been described as 'natural tumour suppressors'. We now need to understand more about their origin and to reconsider their place in the complex process of mammary morphogenesis. In the present review, we discuss the lineage segregation of mammary myoepithelial cells and their functions in mammary gland development. These functions include their effects on luminal cell growth and differentiation, their key role in the establishment of the polarised mammary epithelial bilayer and the control of stromal invasion in breast cancer.
Deugnier
Marie-Ange
MA
UMR 144 CNRS-Institut Curie, Section de Recherche, Paris, France.
Teulière
Jérôme
J
Faraldo
Marisa M
MM
Thiery
Jean Paul
JP
Glukhova
Marina A
MA
D000818:Animals; D001940:Breast / Q000166:cytology* / Q000378:metabolism; D001943:Breast Neoplasms / Q000473:pathology; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D005260:Female; D006801:Humans; D014176:Protein Biosynthesis