title: [Treatment of chronic pain--use of transdermal fentanyl (Durogesic TTS)].
abstract: Incorrect treatment of chronic pain is common cause of patient's discontentment and suffering. The problem is mostly occurring because of inappropriate pain treatment. The WHO guidelines recommends declining of prejudices and using of strong opioids in therapy after the unsatisfactory treatment with weaker analgesics. Strong opioid analgesic fentanyl in transdermal system (Durogesic TTS) is introduced. In rheumatology, it is recommended for all conditions characterised by chronic pain with intensity 4 and more on the VAS scale (0-10). It is mostly used in rheumatoid arthritis, osteoarthritis, low back pain and neuropathic pain. Durogesic TTS provides continuous pain relief for 72 hours, with constant serum concentrations. It has to be gradually titrated and starting dose is 25 micrograms/h. Possible adverse events (nausea, vomiting, constipation, sedation, itching) are short termed, transitory and easily managed. Results of some clinical trials and personal experiences that are proving its efficacy and safety are presented.
authors.affiliation: Klinika za reumatske bolesti i rehabilitaciju, KBC Zagreb, Zagreb.
authors.forename: Durdica
authors.initials: D
authors.lastname: Babić-Naglić
authors.forename: Zrinka
authors.initials: Z
authors.lastname: Jajić
authors.forename: Zoja
authors.initials: Z
authors.lastname: Gnjidić
authors.forename: Biserka
authors.initials: B
authors.lastname: Stambuk
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012216:Rheumatic Diseases / Q000150:complications*
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl