title: Protein-energy undernutrition and life-threatening complications among the hospitalized elderly.
abstract: OBJECTIVE
  To determine whether elderly patients with protein-energy undernutrition at admission are at increased risk for subsequent life-threatening events after controlling for illness severity.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University-affiliated Department of Veterans Affairs hospital.
  
  
  METHODS
  Five hundred eighty-six nonterminal patients (mean age 74 +/- 6 [SD] years, 98% male, 86% white) with a length of stay of 3 days or more.
  
  
  METHODS
  Life-threatening complications.
  
  
  RESULTS
  Subsequent to admission, 37 subjects (6.3%) experienced at least 1 life-threatening complication. All of the putative nutrition variables examined and many non-nutrition, illness severity measures were strongly correlated with the risk of a life-threatening complication by univariate analyses (P <.05 for all analyses). After controlling for illness severity, admission serum albumin, prealbumin, and cholesterol were no longer significantly correlated with the outcome. In contrast, weight loss (>5% within 6 months), body mass index, mid-arm circumference, and suprailiac skinfold thickness remained strong independent predictors. The adjusted relative risk of a life-threatening complication ranged from 2.9 (95% confidence interval [CI], 1.3 to 6.4) for a body mass index <22 kg/m2 to 7.1(95% CI, 2.0 to 25.7) for a suprailiac skinfold thickness in the lower tertile for the study population. The putative nutrition and illness severity variables were highly intercorrelated.
  
  
  CONCLUSIONS
  There is a complex interrelationship between nutritional status, illness severity, and clinical outcomes among the hospitalized elderly. The serum secretory proteins and cholesterol are correlated with other indicators of illness severity and adverse outcomes, but may not be good markers of nutritional risk. In contrast, weight loss, a low body mass index, and other indicators of lean and fat mass depletion appear to place the patient at increased risk for adverse outcomes independent of illness severity. Whether it is possible to reverse such established nutritional deficits and reduce complication risk in the acute care setting remains to be determined.
authors.affiliation: Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Ark. 72205, USA. sullivandennish@uams.edu
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Sullivan
authors.forename: Melinda M
authors.initials: MM
authors.lastname: Bopp
authors.forename: Paula K
authors.initials: PK
authors.lastname: Roberson
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications*; D005260:Female; D015577:Geriatric Assessment; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000150:complications; D016015:Logistic Models; D008297:Male; D009752:Nutritional Status; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000150:complications*; D012720:Severity of Illness Index