[Allogeneic bone marrow transplantation for the treatment of Bruton disease].
OBJECTIVE
To explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease.


METHODS
HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.


RESULTS
Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease.


CONCLUSIONS
Stem cell transplantation is a choice for the treatment of Bruton disease.
Huang
Xiaojun
X
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
Shi
Hongxia
H
Guo
Nailan
N
Lu
Daopei
D
D000361:Agammaglobulinemia / Q000097:blood / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D006454:Hemoglobins; D007136:Immunoglobulins