title: [A case of effective weekly paclitaxel administration for metastatic gastric cancer].
abstract: We report a case of effective weekly paclitaxel (TXL) administration for metastatic gastric cancer. TXL (80 mg/m2) was infused over 1 hour after short premedication on an outpatient basis. Administration was continued for 3 weeks followed by 1 week rest. A 74-year-old man was diagnosed with recurrence 49 months after surgery for gastric cancer. He was treated with 5-fluorouracil and cisplatin, and thrombocytopenia (grade 3) and creatinin elevation (grade 1) were observed and assessed as progressive disease 2 months after the treatment. We attempted weekly TXL administration and after 5 courses assessed the patient as having a partial response. The treatment is ongoing. The toxic event was leukopenia (grade 2), with no episode of thrombocytopenia. The patient did not complain of nausea or vomiting, and his quality of life was fair during the treatment. Weekly TXL administration is a useful treatment for metastatic gastric cancer.
authors.affiliation: Dept. of Surgery, Itami City Hospital.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kokufu
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tanei
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Fukuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Tokiharu
authors.initials: T
authors.lastname: Yano
authors.forename: Katsumi
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000553:Ambulatory Care; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel