title: Maximum likelihood inference for multivariate frailty models using an automated Monte Carlo EM algorithm.
abstract: We present a maximum likelihood estimation procedure for the multivariate frailty model. The estimation is based on a Monte Carlo EM algorithm. The expectation step is approximated by averaging over random samples drawn from the posterior distribution of the frailties using rejection sampling. The maximization step reduces to a standard partial likelihood maximization. We also propose a simple rule based on the relative change in the parameter estimates to decide on sample size in each iteration and a stopping time for the algorithm. An important new concept is acquiring absolute convergence of the algorithm through sample size determination and an efficient sampling technique. The method is illustrated using a rat carcinogenesis dataset and data on vase lifetimes of cut roses. The estimation results are compared with approximate inference based on penalized partial likelihood using these two examples. Unlike the penalized partial likelihood estimation, the proposed full maximum likelihood estimation method accounts for all the uncertainty while estimating standard errors for the parameters.
authors.affiliation: Rolf Nevanlinna Institute, University of Helsinki, Finland. samuli.ripatti@rni.helsinki.fi
authors.forename: Samuli
authors.initials: S
authors.lastname: Ripatti
authors.forename: Klaus
authors.initials: K
authors.lastname: Larsen
authors.forename: Juni
authors.initials: J
authors.lastname: Palmgren
mesh_terms: D000465:Algorithms; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic; D003718:Denmark; D016013:Likelihood Functions; D009010:Monte Carlo Method; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D027824:Rosaceae / Q000502:physiology; D013548:Sweden
chemical_list: D002273:Carcinogens