Chemical sympathectomy increases numbers of inflammatory cells in the peritoneum early in murine listeriosis.
Here, we investigated the effects of sympathectomy on systemic bacterial loads following infection with Listeria monocytogenes, and on innate and specific immune responses in the peritoneum. Sympathectomy decreased systemic bacterial loads, and increased the number of peritoneal leukocytes and the percentage of peritoneal macrophages three days postinfection. This suggests that sympathectomy-induced decreases systemic bacterial loads are associated with increased recruitment of inflammatory cells into tissues during the innate immune response.
Rice
P A
PA
Department of Pulmonary and Critical Care Medicine, University of Maryland, 3C116, VAMC 10 N. Greene Street, Baltimore, MD 21201, USA. penelope_rice@yahoo.com
Boehm
G W
GW
Moynihan
J A
JA
Bellinger
D L
DL
Stevens
S Y
SY
D000818:Animals; D007371:Interferon-gamma / Q000097:blood; D008088:Listeriosis / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000382:microbiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D010537:Peritoneum / Q000276:immunology* / Q000294:innervation; D010538:Peritonitis / Q000276:immunology* / Q000382:microbiology; D010586:Phagocytes / Q000166:cytology / Q000382:microbiology; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D013563:Sympathectomy, Chemical; D013565:Sympatholytics
D013565:Sympatholytics; D007371:Interferon-gamma; D016627:Oxidopamine; D009638:Norepinephrine