title: [Multicenter Study of Efficacy and Safety of a Preparation of Lovastatin in Patients With Ischemic Heart Disease and Mild or Moderate Hypercholesterolemia]
abstract: Ninety patients with ischemic heart disease and mild or moderate hypercholesterolemia were included in a multicenter study of efficacy and safety of a preparation of lovastatin (Holetar, KRKA). After 6 weeks of a diet period 46 patients remained on diet and in 44 patients lovastatin was added to diet for 12 weeks. All patients received 20 mg/day for 6 weeks. If after 6 weeks on lovastatin target level of low density lipoprotein cholesterol (LDL CH, 3.0 mmol/l) was not achieved the dose was doubled. Target LDL CH level was achieved in 47% and 58% of patients by the end of 6 and 12 weeks, respectively. The 20 mg dose lowered levels of LDLCH by 27% and of triglycerides by 10%. The drug was well tolerated.
authors.affiliation: Cardiology Research Complex, 3rd Cherepkovskaia, 15a, 121552 Moscow, Russia.
authors.forename: Iu. P.
authors.initials: IP
authors.lastname: Nikitin
authors.forename: G. I.
authors.initials: GI
authors.lastname: Simonova
authors.forename: V. Iu.
authors.initials: VI
authors.lastname: Mareev
authors.forename: E. V.
authors.initials: EV
authors.lastname: Shliakhto
authors.forename: O. A.
authors.initials: OA
authors.lastname: Berkovich
authors.forename: F. T.
authors.initials: FT
authors.lastname: Ageev