Asthma remission: does it exist?
Subjects believed to have grown out of asthma often develop symptoms again later in life. Ongoing airway inflammation may determine the risk of relapse, although the mechanisms involved are still misunderstood. Additionally, patients with asthma during childhood may develop irreversible airflow obstruction ( airway remodeling) as a result of chronic airway inflammation. Recently, airway inflammation and remodeling could be demonstrated in bronchial biopsy specimens from young adults who considered themselves grown out of asthma. It is also shown that evidence of airway inflammation and remodeling can be obtained noninvasively, thereby providing the opportunity to monitor disease activity. If chronic airway inflammation and/or remodeling are consistent findings in asymptomatic subjects with a history of atopic asthma, the question arises whether natural history can be positively altered with prolonged antiinflammatory therapy. Benefits of long-term prognosis are, however, not yet shown. Since epidemiologic work has demonstrated that a certain percentage of subjects with apparently outgrown atopic asthma remains asymptomatic without needing therapy for the rest of their lives, it can be argued that "asthma remission does exist." The question is whether this percentage can be increased with prolonged antiinflammatory therapy and regular control.
van den Toorn
Leon M
LM
Department of Pediatrics/Pediatric Respiratory Medicine, Erasmus MC, Rotterdam, the Netherlands. Lvandentoorn@planet.nl
Overbeek
Shelley E
SE
Prins
Jan-Bas
JB
Hoogsteden
Henk C
HC
de Jongste
Johan C
JC
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000473:pathology* / Q000503:physiopathology*; D001485:Basement Membrane / Q000473:pathology; D001707:Biopsy, Needle; D001980:Bronchi / Q000473:pathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002648:Child; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020127:Recovery of Function; D012075:Remission, Spontaneous; D012129:Respiratory Function Tests; D020545:Respiratory Mucosa / Q000473:pathology; D018570:Risk Assessment; D012680:Sensitivity and Specificity