title: Comparison of leuprolide acetate and triptorelin in assisted reproductive technology cycles: a prospective, randomized study.
abstract: OBJECTIVE
  To compare the use of two depot GnRH-a, leuprolide and triptorelin, in long-suppression GnRH-a protocols.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
  
  
  METHODS
  Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle. Stimulation with gonadotropins was initiated after pituitary desensitization was achieved.
  
  
  METHODS
  The stimulation pattern and cycle outcomes were compared between the two groups.
  
  
  RESULTS
  Twenty-six patients were included in each group. No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred. However, significantly higher clinical implantation and pregnancy rates were found in the leuprolide group compared with the triptorelin group.
  
  
  CONCLUSIONS
  A depot preparation of leuprolide is associated with higher implantation and pregnancy rates than a depot preparation of triptorelin when it is used in the midluteal phase as part of the long-suppression GnRH-a protocol in IVF.
authors.affiliation: Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Ram
authors.initials: R
authors.lastname: Kerner
authors.forename: Haim
authors.initials: H
authors.lastname: Krissi
authors.forename: Jacob
authors.initials: J
authors.lastname: Ashkenazi
authors.forename: Zion
authors.initials: Z
authors.lastname: Ben Rafael
authors.forename: Itai
authors.initials: I
authors.lastname: Bar-Hava
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D005300:Fertility Agents, Female; D017329:Triptorelin Pamoate; D016729:Leuprolide