title: [Bronchectasia and microscopic polyangeitis].
abstract: Microscopic polyangeitis is a necrosing vascularitis with pulmonary and renal tropism. Localized in the lung, microscopic polyangeitis leads to intra-alveolar hemorrhage. We report our observations in two patients who presented with concomitant bronchectasia. The parallel course of these two conditions suggests a possible relationship. We propose a pathophysiological approach involving a direct role of polymorphonuclear neutrophils and neutrophilic proteases secreted in response to activation of anti-polymorphonuclear cytoplasm anti-bodies (ANCA) during microscopic polyangeitis aggravating bronchectasia.
authors.affiliation: Service de Pneumologie, 2 bis, boulevard Tonnellé 37000 Tours. diot@med.uni-tours.fr
authors.forename: J-C
authors.initials: JC
authors.lastname: Koninck
authors.forename: E
authors.initials: E
authors.lastname: Diot
authors.forename: E
authors.initials: E
authors.lastname: Hazouard
authors.forename: M-C
authors.initials: MC
authors.lastname: Machet
authors.forename: J-F
authors.initials: JF
authors.lastname: Valentin
authors.forename: E
authors.initials: E
authors.lastname: Lemarie
authors.forename: P
authors.initials: P
authors.lastname: Diot
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001987:Bronchiectasis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008168:Lung / Q000098:blood supply*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D014657:Vasculitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D007166:Immunosuppressive Agents; D008775:Methylprednisolone