[Testosterone and male osteoporosis].
There are various causes for male osteoporosis. The low testosterone level is one of the important reasons. Androgen does not only play an important role in gaining the peak bone mass and maintaining the bone mass, but also has an intimate correlation with the bone loss with ageing. Androgen affects osteoblasts through androgen receptors. Various local cell factors play regulating roles. The partial testosterone replacement therapy in aging men could elevate the bone mass density, but the advantages and the disadvantages should be observed further. The function of the estrogen in male osteoporosis is being noted as well.
Jin
Jia-Lin
JL
Department of Geriatrics, Affiliated Medical College, Drum Tower Hospital of Nanjing University, Nanjing, Jiangsu 210008, China.
Tian
Cheng-Gong
CG
D000367:Age Factors; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism* / Q000627:therapeutic use
D013739:Testosterone