Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.
The Drosophila linotte1 mutation was isolated from a genetic screen designed to identify learning and memory genes. For some authors, this mutation affects a novel gene specifically involved in adult learning and memory, whereas for others, it is an allele of the derailed receptor tyrosine kinase gene (the linotte/derailed gene) involved in nervous system development. Here, we show that the original derailed mutation induces a memory phenotype. We also report that a new null mutation, lioexc21, affecting specifically the linotte/derailed gene causes behavioral defects, which can be partially rescued by expression of a lio+/drl+ transgene. The data presented here suggest that the memory phenotype of linotte and derailed mutants is a consequence of abnormal brain development due to loss of function of the linotte/derailed encoded receptor tyrosine kinase.
Moreau-Fauvarque
Caroline
C
Institut de Génétique Humaine, CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Taillebourg
Emmanuel
E
Préat
Thomas
T
Dura
Jean-Maurice
JM
D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D030801:Animals, Genetically Modified; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000002:abnormalities* / Q000503:physiopathology; D029721:Drosophila Proteins / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009421:Nervous System Malformations / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000172:deficiency* / Q000235:genetics; D012903:Smell / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
D029721:Drosophila Proteins; D012333:RNA, Messenger; C096467:pigeon protein, Drosophila; C094492:DRL protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases