title: [Metabolic syndrome from the point of view of a cardiologist: diagnosis, non drug and drug treatment].
abstract: Timely diagnosis and treatment of metabolic syndrome is important because of high prevalence of this pathology in population. For the elaboration of approaches to complex treatment of this syndrome it is necessary to understand pathogenetic mechanisms of development of hypertension and metabolic changes as well as acquire an array of non drug and drug methods of influence on elevated blood pressure and disordered carbohydrate, lipid and purine metabolism. Phenylalkylamine calcium antagonists should be used as drugs of choice for treatment of hypertension. These agents exert slowing of heart rate, coronarolytic and antiatherogenic effects, the latter being especially important in this group of patients. Resistance of hypertension to treatment developing on the background of insulin resistance of peripheral tissues dictates necessity of the use of combinations of antihypertensive drugs with consideration of their metabolic effects. For correction of metabolic changes metformin is used in addition to non drug methods which include diet and exercise. Treatment with metformin allows to decrease insulin resistance and thus severity of derangements of metabolism.
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.forename: D A
authors.initials: DA
authors.lastname: Napalkov
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002309:Cardiology / Q000379:methods*; D015444:Exercise; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D008687:Metformin / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D008687:Metformin