title: The use of substrate engineering in biohydroxylation.
abstract: In the biohydroxylation of nonactivated carbon atoms, substrate engineering has been found to be a very useful and simple means to influence substrate acceptance and the regioselectivity and stereoselectivity of this transformation. Recently, this methodology has been applied to the hydroxylation of a large number of compounds including cycloalkane carboxylic acids, ketones, amines, amides and alcohols.
authors.affiliation: Institute of Organic Chemistry, Technical University Graz, Stremayrgasse 16, A-8010, Graz, Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: de Raadt
authors.forename: Herfried
authors.initials: H
authors.lastname: Griengl
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D005658:Fungi / Q000378:metabolism*; D006900:Hydroxylation; D008084:Lipoxygenase / Q000737:chemistry / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D006899:Mixed Function Oxygenases; D008084:Lipoxygenase