title: Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva.
abstract: Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC 50 values below 1 ng/ml.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, the University of Illinois at Chicago, Chicago, Illinois 60612, USA.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Tamez
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Aydogmus
authors.forename: Ghee Teng
authors.initials: GT
authors.lastname: Tan
authors.forename: Yoko
authors.initials: Y
authors.lastname: Saikawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masaya
authors.initials: M
authors.lastname: Nakata
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Hung
authors.forename: Le Thi
authors.initials: le T
authors.lastname: Xuan
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: D Doel
authors.initials: DD
authors.lastname: Soejarto
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D029064:Araceae; D030681:Ficus; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D014255:Trichothecenes; C472149:satratoxin H 12',13'-diacetate; C472148:satratoxin H 13'-acetate; C472147:verrucarin L acetate; C014184:satratoxin H; C003797:roridin E