title: Preparation of [11C] radioligands with high specific radioactivity on a commercial PET tracer synthesizer.
abstract: High specific radioactivity is required for receptor studies with PET. Hereby we wish to report our experience using Nuclear Interface PET Tracer Synthesizer for preparation of Carbon-11 radioligands and module's modifications, which allowed to achieve high specific radioactivity.
authors.affiliation: IBFH-CNR, University of Milano/Bicocca, Institute H San Raffaele, Milano, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Matarrese
authors.forename: Dmitri
authors.initials: D
authors.lastname: Soloviev
authors.forename: Sergio
authors.initials: S
authors.lastname: Todde
authors.forename: Felice
authors.initials: F
authors.lastname: Neutro
authors.forename: Pasquale
authors.initials: P
authors.lastname: Petta
authors.forename: Assunta
authors.initials: A
authors.lastname: Carpinelli
authors.forename: Michael
authors.initials: M
authors.lastname: Brüssermann
authors.forename: Marzia
authors.initials: M
authors.lastname: Galli Kienle
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D004867:Equipment Design; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods*; D008024:Ligands; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; D002245:Carbon Dioxide