title: Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.
abstract: [structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Youseung
authors.initials: Y
authors.lastname: Shin
authors.forename: Nakyen
authors.initials: N
authors.lastname: Choy
authors.forename: Tiffany R
authors.initials: TR
authors.lastname: Turner
authors.forename: Raghavan
authors.initials: R
authors.lastname: Balachandran
authors.forename: Charitha
authors.initials: C
authors.lastname: Madiraju
authors.forename: Billy W
authors.initials: BW
authors.lastname: Day
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Curran
mesh_terms: D000473:Alkanes; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002219:Carbamates; D005260:Female; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D018942:Macrolides; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D011753:Pyrones; D014407:Tumor Cells, Cultured
chemical_list: D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D018942:Macrolides; D011753:Pyrones; C470814:dictyostatin; C071229:discodermolide