[Prevalence of detection of autoantibodies to beta-1 adrenoreceptors in patients with myocarditides and cardiomyopathies].
BACKGROUND
Autoantibodies to the second extracellular loop of a cardiac beta1-adrenoreceptors has been detected in some patients with cardiomyopathies and myocarditides. In animal experiments these autoantibodies have been shown to cause reduction of myocardial contractility.


OBJECTIVE
To estimate prevalence of detection of autoantibodies to beta1-adrenoreceptors in patients with myocarditides and cardiomyopathies.


METHODS
Forty three patients including 18 with dilated cardiomyopathy (DCM), 14 with ischemic heart disease (IHD), 3 with myocarditides, 1 with alcoholic cardiomyopathy and 7 after cardiac transplantation.


METHODS
Autoantibodies to beta1-adrenoreceptor were determined in patient's blood serum by direct immunoassay. Synthetic fragment containing 26 amino acids of the beta1-adrenoreceptor second loop was used as antigen.


RESULTS
Ten patients had obviously elevated content of autoantibodies. Three of these patients had IHD, 3 - DCM, 1 was studied 6 moths after myocarditis and 3 - 6-9 years after cardiac transplantation. Tests were repeated with intervals from 6 months to 1 year and levels of autoantibodies remained elevated in all these patients. Detection of antibodies did not depend on the etiology of systolic cardiac failure (IHD, DCM), severity of hemodynamic impairment, presence of disorders of cardiac rhythm or conduction.
Tabak'ian
E A
EA
Kukharchuk
V V
VV
Naumov
V G
VG
Dzemeshkevich
S L
SL
Perov
P Iu
PIu
Tonevitskiĭ
A G
AG
Belenkov
Iu N
IuN
Shumakov
V I
VI
D001323:Autoantibodies / Q000276:immunology*; D009202:Cardiomyopathies / Q000453:epidemiology* / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000453:epidemiology* / Q000276:immunology* / Q000503:physiopathology; D015995:Prevalence; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology*
D001323:Autoantibodies; D018342:Receptors, Adrenergic, beta-1