[The analysis of thymidine phosphorylase examined by ELISA in bladder cancer].
OBJECTIVE
Some reports suggest that the high level expression of thymidine phosphorylase (TP), which is known as one of angiogenic factors, is related to high malignancy and also poor prognosis in the field of gastrointestinal cancer. So the authors investigated the expression of TP in bladder cancer.


METHODS
The expression of TP in cancer tissues and normal tissues, which were obtained during transurethral resection of the tumor of 66 patients with initial primary bladder cancer, was examined by enzyme-linked immunosorbent assay (ELISA). And relationship of the TP expression and clinicopathologic factors was investigated.


RESULTS
The level of TP expression was significantly high in cancer tissues compared with normal tissues (P < 0.0001). About the level of TP expression of cancer tissues, there was a significant difference between G1 and G3 in grade (P = 0.0099), Ta and T2 or greater (P = 0.0059), Ta, T1 and T2 or greater (P = 0.0157) in T stage, papillary and non-papillary in surface form (P = 0.0056), pedunculated and sessile in tumor shape (P = 0.0458), and 1 cm or under and 3 cm or greater in size (P = 0.0267). The level was higher in latter, respectively. About the level of TP expression of normal tissues, the level was significantly higher in the cases with sessile tumor than the cases with pedunculated tumor (P = 0.0078).


CONCLUSIONS
There is correlation between the level of TP expression of cancer tissues and their grade of malignancy, so we can expect that the level of TP expression of cancer tissues will be a prognostic factor. And what does it mean in the fact that the level of TP expression of normal tissues in patients with sessile tumor is higher? It should be clear after accumulation of the cases and collecting the episodes in the follow-up period.
Saegusa
Michihisa
M
Department of Urology, Hiroshima City Hospital.
Takao
Akira
A
Manabe
Daisuke
D
Ichikawa
Takaharu
T
Aramaki
Kenji
K
Nakayama
Yasuki
Y
Yamada
Daisuke
D
D002295:Carcinoma, Transitional Cell / Q000201:enzymology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013939:Thymidine Phosphorylase / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000473:pathology
D013939:Thymidine Phosphorylase