title: [Immunoelectron microscopic analysis of intraglomerular deposits in IgA-dominant immunotactoid glomerulopathy].
abstract: Immunotactoid glomerulopathy (ITG) demonstrates glomerular deposits that are characterized by highly organized ultrastructure. The deposits appear to be composed of immunoglobulin and complement that were negative for amyloid by Congo red stain. However, it has been difficult to distinguish the difference between ITG and fibrillary glomerulonephritis. In the present study, we performed an immunoelectron microscopic study to identify the factors that seemed to be associated with the glomerular deposits in a case of IgA-dominant ITG. IgA, light chain kappa and fibrinogen were colocalized in association with fibrillar deposits in the extracellular matrix of mesangial cells. Therefore, it is likely that the complex of IgA, light chain kappa and fibrinogen are associated with the formation of highly organized ultrastructural deposits in a case of IgA-dominant ITG.
authors.affiliation: Tokyo Women's Medical University, Kidney Center, Shinjuku-ku, Tokyo 162-8666.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Kawashima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Horita
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Keiko
authors.initials: K
authors.lastname: Uchida
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nihei
mesh_terms: D005340:Fibrinogen / Q000378:metabolism; D005921:Glomerulonephritis / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron
chemical_list: D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D005340:Fibrinogen