title: [Results of 6-Month Follow-up of Patients With Non-ST-Elevation Acute Coronary Syndrome Treated With Enoxaparin. Data of Multicenter Study in Russia]
abstract: Two hundred eighty four patients aged 30-85 (mean 62-/+10.2) years hospitalized because of prolonged attack of rest angina were included into open noncomparative study of enoxaparin tolerability. In addition to conventional aspirin the patients received enoxaparin (1 mg or 100 anti-Xa U/kg subcutaneously) every 12 hours for 2-8 days. Events registered during follow-up for 6 months were deaths, nonfatal myocardial infarctions, attacks of angina with new ischemic ECG changes during initial hospitalization, and anginal attacks causing repeat hospitalization. Total number of patients with these events during first 15 days was 11.3% (including 1 death and 3 nonfatal myocardial infarctions). After 6 months number of events almost doubled and reached 20.6%. Most pronounced was increase in numbers of deaths and nonfatal infarctions (up to 11 and 10 events, respectively). During period of follow-up most of patients continued to take aspirin and beta blockers, while myocardial revascularization was performed in 6 patients, and use of statins was negligible. Among 32 parameters (demographic data, medical history, characteristics of index exacerbation of coronary artery disease and therapy) included into multifactorial analysis only actual decisions of physicians (prolongation of treatment with enoxaparin, the use of calcium antagonists) were independent predictors of angina recurrence. Apparently these decisions better reflected real severity of patients clinical condition then ihobjectiveln parameters registered by investigators.
authors.affiliation: Institute Physical-Chemical Medicine, Laboratory of Clinical Cardiology, Malaia Pirogovskaia, 1a, 119828 Moscow, Russia.
authors.forename: I. S.
authors.initials: IS
authors.lastname: Iavelov
authors.forename: N. A.
authors.initials: NA
authors.lastname: Gratsianskiĭ
authors.forename: E. V.
authors.initials: EV
authors.lastname: Pokrovskaia