title: Efficacy of sequential chemotherapy including methotrexate and doxorubicin in an infant with partially resected choroid plexus carcinoma.
abstract: This report refers to a 3-month-old male, with a residual choroid plexus carcinoma following partial resection, who was successfully treated with sequential chemotherapy without any postoperative radiation therapy. Along with carboplatin, we also used doxorubicin and methotrexate, hypothesizing that, given the patient's age, the blood-brain barrier should not hamper drug delivery to the tumor. According to this hypothesis, the treatment achieved complete remission of the disease, which lasts 27 months after the diagnosis. This result deserves further studies to assess the possible curative role of chemotherapy in very young patients suffering from choroid plexus carcinoma.
authors.affiliation: Department of Pediatrics, University Federico II, Via S. Pansini 5, I-80131 Naples, Italy. afiorill@unina.it
authors.forename: Amedeo
authors.initials: A
authors.lastname: Fiorillo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maggi
authors.forename: Sossio
authors.initials: S
authors.lastname: Cirillo
authors.forename: Roberta
authors.initials: R
authors.lastname: Migliorati
authors.forename: Floriana
authors.initials: F
authors.lastname: Buffardi
authors.forename: Elvira
authors.initials: E
authors.lastname: Alfieri
authors.forename: M Simona
authors.initials: MS
authors.lastname: Sabbatino
authors.forename: Alessandra
authors.initials: A
authors.lastname: D'Amico
authors.forename: M Laura
authors.initials: ML
authors.lastname: DelBasso DeCaro
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage* / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D016545:Choroid Plexus Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin; D016190:Carboplatin; D008727:Methotrexate