[Advances in sperm capacitation].
Sperm must be capacitated before sperm-ovum fusion. Capacitation was once considered as hyperactivation. But now many investigators thought that capacitation wasn't equal to hyperactivation, and that sperm hyperactivation might be a moiety of capacitation or the result of capacitation. In the present, the methods used to study sperm capacitation include fertilization in vitro, induction of sperm acrosome reaction, FITC-labeled chlortetracycline and plant hemoagglutinin. The studies on sperm capacitation in vitro mainly focused on the inductive substances of sperm capacitation and subsequent results analysis. It could lay foundation for the manifestation of molecular mechanism of sperm capacitation and destination of sperm capacitation in molecular levels.
Lu
Jin-Chun
JC
Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Zhang
Fu-Quan
FQ
Huang
Yu-Feng
YF
Zhang
Xi-Ran
XR
D000262:Adenylyl Cyclases / Q000502:physiology; D001639:Bicarbonates / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008297:Male; D010766:Phosphorylation; D013075:Sperm Capacitation / Q000187:drug effects / Q000502:physiology*; D013081:Sperm Motility
D001639:Bicarbonates; D000262:Adenylyl Cyclases; D002118:Calcium