[Expression of heme oxygenase-1 and its effects in allergic airway inflammation and hyperresponsiveness].
We investigated whether an expression of hemeoxygenase-1 (HO-1) within the lung tissue is related to allergic airway inflammation and HO-1 expression could influence airway hyperreactivity (AHR) and eosinophilia in C57BL/6 mice actively sensitized to ovalbumin. The number of HO-1 positive cells was increased in the subepithelium of the bronchi after OVA challenge and HO-1 was localized to alveolar macrophage.Zinc-protoporphyrin (Zn-PP), a competitive inhibitor of hemeoxygenase, by intraperitoneal injection clearly inhibited AHR, pulmonary eosinophilia and IL-5 and IL-13 in the lung tissue. These data indicate that the expression of HO-1 is increased within the lung tissue in allergic airway inflammation and the overexpression of HO-1 could enhanced allergic airway inflammation.
Kitada
Osamu
O
Division of Respiratory Medicine, Respiratory Care Unit, Dept. of Internal Medicine, Hyogo College of Medicine, Japan. hyogo5di@hyo-med.ac.jp
D000818:Animals; D001249:Asthma / Q000378:metabolism* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis* / Q000502:physiology; D051547:Heme Oxygenase-1; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D011524:Protoporphyrins / Q000008:administration & dosage
D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D010047:Ovalbumin; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse