Determinants for lentiviral infection of non-dividing cells.
Lentiviruses share the common characteristic of infecting non-dividing target cells, distinguishing them from the oncogenic retroviruses which only productively infect dividing cells. The search for determinants for infection of non-dividing cells has produced a number of candidates. From HIV-1, the viral proteins matrix, integrase and Vpr have all been implicated. A structural determinant, the central DNA flap, has also been implicated. The supporting evidence for each of these proposed determinants will be examined and compared to how other viruses, non-retroviruses, transport their genomes to the nucleus. With currently available data, integrase and the central DNA flap appear to be the key players, and yet the mechanism for infection of non-dividing cells remains undefined.
Vodicka
M A
MA
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002455:Cell Division; D002477:Cells / Q000166:cytology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D016334:Genes, vpr; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006801:Humans; D016086:Lentivirus / Q000235:genetics / Q000502:physiology*
D004279:DNA, Viral