title: Results of a pilot intervention trial to improve antiretroviral adherence among HIV-positive patients.
abstract: A small pilot trial of a multicomponent (behavioral strategies, simplified patient information, and social support) and multidisciplinary (cognitive-behavioral therapy and nursing) medication adherence intervention was conducted for HIV-infected adults prescribed antiretrovirals. Patients (N = 33) were randomly assigned to the intervention condition or standard care. Compared to the control group, patients in the intervention condition had significantly higher self-efficacy to communicate with clinic staff (p = .04) and to continue treatment (p = .04), were significantly more likely to be using behavioral and cognitive strategies (p = .01 and p = .04), reported significantly higher life satisfaction (p = .03), reported significantly increased feelings of social support (p = .04), and showed a trend toward an increase in taking their medications on schedule (p = .06). The intervention, however, did not appear to affect health-related anxiety or to significantly improve adherence to dose. Implications for future intervention planning are discussed.
authors.affiliation: Department of Psychiatry, University of California, Los Angeles, USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Murphy
authors.forename: Michael C
authors.initials: MC
authors.lastname: Lu
authors.forename: David
authors.initials: D
authors.lastname: Martin
authors.forename: Dannie
authors.initials: D
authors.lastname: Hoffman
authors.forename: William D
authors.initials: WD
authors.lastname: Marelich
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002140:California; D015928:Cognitive Behavioral Therapy; D005260:Female; D015658:HIV Infections / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010865:Pilot Projects; D011615:Psychotherapy, Group; D012944:Social Support