Centrosomes and tumour suppressors.
Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.
Fisk
Harold A
HA
Molecular, Cellular and Developmental Biology, UCB347, University of Colorado, Boulder, CO 80309-0347, USA.
Mattison
Christopher P
CP
Winey
Mark
M
D000818:Animals; D018385:Centrosome / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D008954:Models, Biological; D009154:Mutation; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*
D025521:Tumor Suppressor Proteins