Long-term survival of renal graft complicated with Burkitt lymphoma.
A 10-year-old boy with steroid-resistant nephrotic syndrome developed disseminated Burkitt lymphoma 2 years after renal transplantation. Treatment consisting of reduction of immunosuppression and polychemotherapy was initiated, and induced complete tumor remission. A severe cerebellar syndrome attributed to high-dose cytarabine occurred during treatment. The patient recovered partially from this complication. Immunosuppression had to be resumed 2 years later because of a chronic rejection. Finally, at last follow-up, the patient was alive with a stable creatinine of 180 micromol/l.
Nathanson
Sylvie
S
Hôpital André Mignot, Service de Pédiatrie, 177 rue de Versailles, 78157 Le Chesnay cedex, France. snathanson@ch-versailles.fr
Lucidarme
Nadine
N
Landman-Parker
Judith
J
Deschênes
Georges
G
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016030:Kidney Transplantation / Q000502:physiology*; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000601:surgery; D013160:Splenic Neoplasms / Q000556:secondary
D000964:Antimetabolites, Antineoplastic; D007166:Immunosuppressive Agents; D003561:Cytarabine; D016572:Cyclosporine; D003404:Creatinine