Effect of polysaccharides from Angelica sinensis on gastric ulcer healing.
Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated.
Ye
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YN
Department of Pharmacology, L02-55, 2/F, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, University of Hong Kong, Hong Kong, PR China.
So
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HL
Liu
E S L
ES
Shin
V Y
VY
Cho
C H
CH
D029971:Angelica sinensis; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009093:Mucus / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000473:pathology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D018809:Proliferating Cell Nuclear Antigen; C044613:angelicae sinensis extract; D066246:ErbB Receptors; D009955:Ornithine Decarboxylase