Bone marrow-derived CD45+ and CD45- cells reside in skeletal muscle.
In this report we examined the kinetics of accumulation in muscle tissue of donor-derived CD45+ and CD45- cells from one to several weeks post-bone marrow transplantation. Only after hemopoiesis is fully reconstituted are CD45+ cells recovered from muscle tissue in proportions similar to ones we reported earlier in non-transplanted mice. Furthermore, using marked donor bone marrow cells, we document that in addition to CD45+ cells, donor-derived CD45- cells with certain phenotypic characteristics progressively accumulate in muscle post-transplantation. The turnover rate and physiologic roles of these populations in muscle are unclear and require further study.
Issarachai
Surasit
S
Division of Hematology, University of Washington, Box 357710, Seattle, WA 98195-7710, USA.
Priestley
Gregory V
GV
Nakamoto
Betty
B
Papayannopoulou
Thalia
T
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000276:immunology; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D006085:Graft Survival; D006410:Hematopoiesis; D006801:Humans; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000032:analysis*; D051379:Mice; D008822:Mice, Transgenic; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D018482:Muscle, Skeletal / Q000166:cytology*; D018183:Transplantation Chimera
D017493:Leukocyte Common Antigens