Unexpected lack of effect of the rifampin-induced P-glycoprotein on the oral bioavailability of its substrate, talinolol, in humans: implication in phenotyping.
Chiou
Win L
WL
Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, The University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA. chiou@uic.edu
Ma
Chien
C
Wu
Ta-Chen
TC
Jeong
Hyun Young
HY
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000284:Administration, Oral; D001682:Biological Availability; D006801:Humans; D010641:Phenotype; D011412:Propanolamines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D013379:Substrate Specificity / Q000187:drug effects / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D011412:Propanolamines; C011550:talinolol; D012293:Rifampin