title: Worsening of V'maxFRC in infants with chronic lung disease in the first year of life: a more favorable outcome after high-frequency oscillation ventilation.
abstract: Little is known about the development of maximal flow at functional residual capacity, a measure of airway patency, in infants with chronic lung disease (CLD). In a follow-up study, we evaluated V'maxFRC in very low birth weight infants with CLD, treated with high-frequency oscillation ventilation (HFOV) or conventional mechanical ventilation. In 36 infants with CLD, V'maxFRC was evaluated at 6 and/or 12 months corrected age, and the relationship between perinatal factors and lung function was studied. Mean (SD) birth weight and gestational age were 837 (152) g and 26.8 (1.7) weeks, respectively. At 6 and 12 months, mean V'maxFRC was significantly below normal. Between 6 and 12 months, there was a mean (95% confidence interval) reduction in V'maxFRC (Z score) of 0.5 (0.2-0.7) (p < 0.001). At 12 months, the mean V'maxFRC (Z score) was higher for children initially treated with HFOV (n = 15), as compared with children treated with conventional mechanical ventilation (n = 16): mean (95% confidence interval) difference was 0.6 (0.2-1.0) (p = 0.008). We conclude that very low birth weight infants with CLD have decreased V'maxFRC that worsen during the first year of life. Initial treatment with HFOV was associated with a more favorable outcome of V'maxFRC at 12 months corrected age.
authors.affiliation: Department of Pediatrics, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Ward
authors.initials: W
authors.lastname: Hofhuis
authors.forename: Marianne W A
authors.initials: MW
authors.lastname: Huysman
authors.forename: Els C
authors.initials: EC
authors.lastname: van der Wiel
authors.forename: Wim P J
authors.initials: WP
authors.lastname: Holland
authors.forename: Wim C J
authors.initials: WC
authors.lastname: Hop
authors.forename: Govert
authors.initials: G
authors.lastname: Brinkhorst
authors.forename: Johan C
authors.initials: JC
authors.lastname: de Jongste
authors.forename: Peter J F M
authors.initials: PJ
authors.lastname: Merkus
mesh_terms: D002908:Chronic Disease; D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy*; D008176:Lung Volume Measurements; D008297:Male; D012121:Respiration, Artificial