Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature.
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.
Klempa
Boris
B
Institute of Virology, Charité School of Medicine, Humboldt University, D-10098 Berlin, Germany.
Schmidt
Heiko A
HA
Ulrich
Rainer
R
Kaluz
Stefan
S
Labuda
Milan
M
Meisel
Helga
H
Hjelle
Brian
B
Krüger
Detlev H
DH
D000818:Animals; D001483:Base Sequence; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae / Q000821:virology*; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics; D011995:Recombination, Genetic