title: Fibrinogen storage disease without hypofibrinogenaemia associated with acute infection.
abstract: OBJECTIVE
  The presence of ground glass hepatocytes in a liver biopsy may be related to different conditions, including fibrinogen storage disease. Three types of fibrinogen storage disease have been described, namely types I, II and III. Type I is an hereditary hypofibrinogenaemia genetically characterized by a mutant variant of the fibrinogen molecule designated as fibrinogen Brescia, consistent with a gamma284 Gly-->Arg mutation. Only rare cases of types II and III fibrinogen storage disease have been described. The purpose of the present paper is to describe two cases of fibrinogen storage disease without associated hypofibrinogenaemia, which appeared during acute infectious diseases.
  
  
  RESULTS
  Both patients were female, aged 77 and 73 years, who developed high transaminases during an infectious disease. In each case blood coagulation tests were within the normal range, and despite clinical and laboratory investigations no possible cause for liver disease could be found. Liver biopsies were performed; in both cases weakly eosinophilic cytoplasmic inclusions were observed. Using immunohistochemistry the inclusions were found to be due to fibrinogen accumulation. At ultrastructural level features corresponding to type II inclusions were observed. Molecular studies, performed in case 2, excluded the mutation typical of type I fibrinogen storage disease. Both patients also presented features of chronic hepatitis. In case 1, giant cell granulomas were additionally present. No close relatives of the patients presented any clinical or laboratory features of liver disease. In both patients altered liver function test values gradually, spontaneously, returned to within normal ranges after infectious disease was resolved.
  
  
  CONCLUSIONS
  These cases suggest that, on rare occasions, hepatocytes may accumulate fibrinogen during an infectious disease.
authors.affiliation: Section of Pathology, Department of Oncology, University of Bologna, Bellaria Hospital, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Marucci
authors.forename: L
authors.initials: L
authors.lastname: Morandi
authors.forename: S
authors.initials: S
authors.lastname: Macchia
authors.forename: C M
authors.initials: CM
authors.lastname: Betts
authors.forename: M L
authors.initials: ML
authors.lastname: Tardio
authors.forename: P R
authors.initials: PR
authors.lastname: Dal Monte
authors.forename: A
authors.initials: A
authors.lastname: Pession
authors.forename: M P
authors.initials: MP
authors.lastname: Foschini
mesh_terms: D000208:Acute Disease; D000347:Afibrinogenemia / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D001996:Bronchopneumonia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D003141:Communicable Diseases / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D003967:Diarrhea / Q000150:complications / Q000378:metabolism / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D005340:Fibrinogen