[Repeated intraperitoneal injection of low-dose CDDP for gastric cancer with ascites owing to peritonitis carcinomatosa].
We attempted treating 5 patients with ascites from peritonitis carcinomatosa of gastric carcinoma using TS-1 as systemic chemotherapy, and repeated intraperitoneal injection of low-dose CDDP for the carcinomatous ascites. TS-1 was administered in the usual manner and repeated intraperitoneal injection of CDDP (10 mg/body) dissolved in physiological saline 20-500 ml was given with an implantable reservoir. In 3 patients, the carcinomatous ascites disappeared, and in 2 other patients they decreased remarkably. As a result, the QOL and PS of all patients were improved. Serum concentration of CDDP suggested that weekly repeated intraperitoneally injected CDDP not only has an effect on peritonitis carcinomatosa, but also functions as a modulator for 5-FU.
Nakagawa
Masahiro
M
Dept. of Internal Medicine, Hiroshima City Hospital.
Ninomiya
Motoki
M
Fujita
Isao
I
Matsubara
Minoru
M
Okamoto
Yuhko
Y
Kawamoto
Hirofumi
H
Araki
Yasuyuki
Y
Inoue
Junichi
J
Sasaki
Hiroshi
H
Takakura
Norinao
N
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001201:Ascites / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D010538:Peritonitis / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000473:pathology*
D000970:Antineoplastic Agents; D002945:Cisplatin