[An experimental study of the inhibition of tamoxifen on rat model of benign prostatic hyperplasia].
OBJECTIVE
To study the inhibitory mechanism of tamoxifen on benign prostatic hyperplasia.


METHODS
The Wistar male adult rats were injected into muscle with testosterone propionate 4-6 mg/kg, simultaneously were irrigated into stomach with tamoxifen citrate 0.21 mg/kg. The partly rats of each group were decapitated at 7, 15 and 30 days, then their index numbers of prostate were calculated, and the structural changes of the prostatic histocyte were observed in the light microscopy and scan electronic microscopy.


RESULTS
At the 7th, 15th, and 30th day, the index numbers of prostate of those rats which had been injected only with testosterone propionate were higher than that of the control group and the irrigating group(P < 0.05). The hyperplasia of the prostatic epithelial cells and the ground substance of those rats, which had been irrigated with tamoxifen citrate, had not happened in light microscopy and the scan electronic microscopy.


CONCLUSIONS
Tamoxifen could block the effect of the estrogen, which could suppress the prostatic hyperplasia. This study could provide the experimental evidences for using Tamoxifen to treat the human benign prostatic hyperplasia.
Chen
Bin
B
Department of Urology, First Affiliated Hospital of Lanzhou Medical College, Lanzhou, Gansu 730000, China.
Bai
Jin-Liang
JL
Zhang
Shi-Sheng
SS
Fu
Wu
W
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome
D013629:Tamoxifen