title: Vertebrobasilar thrombosis in children: report of two cases and recommendations for treatment.
abstract: Two consecutive cases of children with vertebrobasilar thrombosis (VBT) were treated with high-dose intra-arterial urokinase within 4 h of presenting to the emergency room, after full evaluation by CT scan, MRI and MR angiography. Complete resolution of neurologic symptoms was achieved in both cases. Based on our limited pediatric experience, previous treatment of VBT at our institution and a review of the relevant literature, the authors suggest that VBT be specifically ruled out at initial diagnosis, and if present, full consideration be given to immediate treatment with intra-arterial thrombolytic therapy. This may lead to a significant reduction in the morbidity and mortality associated with VBT in children. A large prospective multi-institution study is needed to further evaluate the efficacy of this approach to childhood stroke.
authors.affiliation: Department of Clinical Neurosciences, Brown Medical School, Providence, R.I. 02905, USA.
authors.forename: Arno
authors.initials: A
authors.lastname: Sungarian
authors.forename: John A
authors.initials: JA
authors.lastname: Duncan
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D010960:Plasminogen Activators / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator