title: Ectoderm to mesoderm lineage switching during axolotl tail regeneration.
abstract: Foreign environments may induce adult stem cells to switch lineages and populate multiple tissue types, but whether this mechanism is used for tissue repair remains uncertain. Urodele amphibians can regenerate fully functional, multitissue structures including the limb and tail. To determine whether lineage switching is an integral feature of this regeneration, we followed individual spinal cord cells live during tail regeneration in the axolotl. Spinal cord cells frequently migrate into surrounding tissue to form regenerating muscle and cartilage. Thus, in axolotls, cells switch lineage during a real example of regeneration.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.
authors.forename: Karen
authors.initials: K
authors.lastname: Echeverri
authors.forename: Elly M
authors.initials: EM
authors.lastname: Tanaka
mesh_terms: D000557:Ambystoma / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology; D004475:Ectoderm / Q000166:cytology; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000235:genetics; D008648:Mesoderm / Q000166:cytology; D032342:Muscle Cells / Q000166:cytology* / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D013116:Spinal Cord / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*; D013623:Tail / Q000502:physiology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins