Estrogenic/antiestrogenic activity of homoisoflavonoids from bulbs of Muscari racemosum (L.) Miller.
The homoisoflavonoid fraction obtained from the Muscari racemosum bulb ether extract (MRBEE) exhibited estrogenic activity by inducing proliferation of MCF7 cells in a dose-dependent manner. In the presence of estradiol MRBEE exhibited a dose-dependent antiestrogenic activity.
Urbancíková
M
M
Department of Toxicology and Xenobiotics, Institute of Preventive and Clinical Medicine, Bratislava 83301, Slovakia. urbancik@upkm.sk
Masterová
I
I
Tóth
J
J
D000230:Adenocarcinoma / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D020847:Estrogen Receptor Modulators / Q000302:isolation & purification / Q000494:pharmacology*; D004967:Estrogens / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D020847:Estrogen Receptor Modulators; D004967:Estrogens; D007529:Isoflavones