title: Early increase of lower oesophageal sphincter pressure after band ligation of oesophageal varices in cirrhotics: an intriguing phenomenon.
abstract: OBJECTIVE
  We conducted a prospective, randomized comparison of endoscopic variceal ligation, sclerotherapy and metoclopramide injection in order to evaluate their early effect on lower oesophageal sphincter pressure.
  
  
  METHODS
  Twenty-six patients with established cirrhosis and an episode of variceal bleeding controlled by one session of endoscopic therapy were randomized to undergo an oesophageal manometry. The patients' lower oesophageal sphincter pressure was evaluated, prior to and immediately after a single session of ligation (n = 10), a single session of sclerotherapy (n = 8) or a bolus injection of 20 mg metoclopramide hydrochloride (n = 8).
  
  
  RESULTS
  Ligation produced a higher early increase in lower oesophageal sphincter pressure (from 12.3 +/- 2.3 to 27.8 +/- 3.0 mmHg) as compared with sclerotherapy (from 13.6 +/- 2.5 to 22.4 +/- 4.5 mmHg) or metoclopramide injection (from 14.6 +/- 3.2 to 22.5 +/- 2.9 mmHg); (P = 0.0001).
  
  
  CONCLUSIONS
  Our data indicate that ligation of oesophageal varices produces an early increase in lower oesophageal sphincter pressure in cirrhotic patients.
authors.affiliation: 2nd Department of Gastroenterology, Propaedeutic, Athens University, Evangelismos Hospital, Greece. alavger@hol.gr
authors.forename: Alec
authors.initials: A
authors.lastname: Avgerinos
authors.forename: Nikos
authors.initials: N
authors.lastname: Viazis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Armonis
authors.forename: Jiannis
authors.initials: J
authors.lastname: Vlachogiannakos
authors.forename: George
authors.initials: G
authors.lastname: Rekoumis
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Stefanidis
authors.forename: Nikos
authors.initials: N
authors.lastname: Papadimitriou
authors.forename: Spilios
authors.initials: S
authors.lastname: Manolakopoulos
authors.forename: Sotiris A
authors.initials: SA
authors.lastname: Raptis
mesh_terms: D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005260:Female; D005355:Fibrosis; D006801:Humans; D008026:Ligation / Q000379:methods; D008297:Male; D008365:Manometry; D008787:Metoclopramide / Q000008:administration & dosage; D008875:Middle Aged; D011312:Pressure; D011446:Prospective Studies; D012597:Sclerosing Solutions / Q000008:administration & dosage; D015911:Sclerotherapy / Q000379:methods
chemical_list: D012597:Sclerosing Solutions; D008787:Metoclopramide