PKG and the neural basis for behavioral phenotypes.
Cyclic GMP-dependent protein kinase (PKG) has been implicated in the regulation of diverse aspects of vertebrate and insect behavior, yet the mechanisms underlying these effects are poorly understood. In this issue of Neuron, Fujiwara et al. and L'Etoile et al. address the neural basis for PKG function in C. elegans and demonstrate the power of behavioral genetic analysis in simple systems in the elucidation of neuronal signaling mechanisms in vivo.
Schafer
William R
WR
Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D002450:Cell Communication / Q000235:genetics; D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics
D017869:Cyclic GMP-Dependent Protein Kinases