title: C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.
abstract: The aim of the present study was to investigate the relationship between C-reactive protein (CRP) and insulin resistance in non-obese Japanese type 2 diabetic patients. A total of 135 non-obese Japanese type 2 diabetic patients (96 men and 39 women, aged 36 to 83 years, with a body mass index [BMI] of 16.2 to 26.8 kg/m2) were studied. BMI, glycosylated hemoglobin (HbA(1c)), fasting concentrations of plasma glucose, serum lipids (triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol, and total cholesterol), CRP, and fibrinogen were measured. LDL cholesterol was calculated using the Friedewald formula. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Univariate regression analysis showed that CRP value was positively correlated to age (r = 0.218, P =.012), BMI (r = 0.239, P =.006), HOMA-IR (r = 0.397, P <.0001), triglycerides (r= 0.310, P <.005), LDL cholesterol (r= 0.179, P =.038), and fibrinogen (r = 0.371, P <.0001) levels and inversely correlated to HDL cholesterol (r = 0.174, P =.044) level in our diabetic patients. Multiple regression analysis showed that CRP was independently predicted by HOMA-IR (P<.0001, F = 11.6) and fibrinogen (P<.0001, F = 34.2), which explained 23.5% of the variability of CRP in our non-obese Japanese type 2 diabetic patients. These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients.
authors.affiliation: Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan.
authors.forename: Ataru
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Nagasaka
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sakai
authors.forename: Takahide
authors.initials: T
authors.lastname: Okumura
authors.forename: Satoru
authors.initials: S
authors.lastname: Yoshii
authors.forename: Toshiki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masahito
authors.initials: M
authors.lastname: Ogura
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamadori
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nin
authors.forename: Akira
authors.initials: A
authors.lastname: Kuroe
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Nakai
mesh_terms: D044466:Asian People; D002097:C-Reactive Protein; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013851:Thinness
chemical_list: D008055:Lipids; D005340:Fibrinogen; D002097:C-Reactive Protein