Activation of the phosphatidylinositol-3'-kinase/protein kinase B-dependent antiapoptotic pathway plays an important role in the development of radioresistance of human glioma cells.
Schlegel
J
J
Division of Neuropathology, Munich Technical University D-81675 Munich, Germany. schlegel@neuropathologie-muenchen.de
Durchschlag
G
G
Piontek
G
G
Grosu
A L
AL
D017209:Apoptosis / Q000502:physiology*; D001932:Brain Neoplasms; D004789:Enzyme Activation; D005910:Glioma; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D011836:Radiation Tolerance / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt