title: FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemia.
abstract: We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant (10 out of 29 patients, 34.5%, P = 0.29). In APL patients, FLT3/ITD was strongly correlated to a higher white blood cell count at diagnosis and the M3 French-American-British subtype.
authors.affiliation: Centro Ricerca M. Tettamanti, Clinica Pediatrica Università di Milano Bicocca, Monza, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Arrigoni
authors.forename: Chiara
authors.initials: C
authors.lastname: Beretta
authors.forename: Daniela
authors.initials: D
authors.lastname: Silvestri
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rossi
authors.forename: Carmelo
authors.initials: C
authors.lastname: Rizzari
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Valsecchi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cazzaniga
authors.forename: Andrea
authors.initials: A
authors.lastname: Biondi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D020440:Gene Duplication; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000276:immunology / Q000401:mortality; D007958:Leukocyte Count; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D020080:Tandem Repeat Sequences; D051941:fms-Like Tyrosine Kinase 3
chemical_list: D011518:Proto-Oncogene Proteins; C497970:FLT3 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3