title: Junctional signaling microdomains: bridging the gap between the neuronal cell surface and Ca2+ stores.
abstract: Growing evidence suggests that plasma membranes are locally differentiated into microdomains that are important interaction sites for organization of signaling molecules. These signaling microdomains create local conditions that enhance molecular interactions, excluding others, thereby ensuring speed, spatial localization, and specificity of signal transduction. With the special emphasis on InsP(3) and Ca(2+) signaling pathways, we will discuss here the evolving concept of signaling microdomains that provide a key framework for understanding the differential regulation of many cellular target proteins.
authors.affiliation: Intégration des Informations Sensorielles, CNRS-UMR 6150, Marseille, France. delmas@irlnb.cnrs-mrs.fr
authors.forename: Patrick
authors.initials: P
authors.lastname: Delmas
authors.forename: David A
authors.initials: DA
authors.lastname: Brown
mesh_terms: D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006706:Homeostasis; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism*; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D011956:Receptors, Cell Surface; D015544:Inositol 1,4,5-Trisphosphate; D010738:Type C Phospholipases; D002118:Calcium