Biodendrimers: new polymeric biomaterials for tissue engineering.
Dendrimers composed entirely of building blocks known to be biocompatible or degradable in vivo to natural metabolites were synthesized using a high yield divergent approach. This synthesis is amenable to the design and development of new biomaterials that are of interest for a variety of medical applications, including tissue engineering. In a novel application, photocross-linkable dendrimers are used to seal large corneal lacerations.
Grinstaff
Mark W
MW
Departments of Chemistry, Ophthalmology, and Biomedical Engineering, Paul M. Gross Chemical Laboratory, Room 330, Duke University and Duke Medical Center, Durham, NC 27708, USA. mwg@chem.duke.edu
D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001673:Biodegradation, Environmental; D003315:Cornea; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis; D046911:Macromolecular Substances; D013329:Structure-Activity Relationship; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D020100:Hydrogels; D046911:Macromolecular Substances