[Advances in the research about penile erection related genes].
Molecular biologic research on erectile dysfunction (ED), especially the elucidation of NO-cGMP signaling pathway which plays an important role on modulating corpus cavernosum smooth muscle dilation, has been made the great advance in past ten years. The further research on the penile erection related genes including nitric oxide synthase (NOS), phosphodiesterases (PDEs), K+ channal, insulin-like growth factor (IGF), heme oxygenase (HO), vascular endothelial growth factor (VEGF), cyclic GMP-dependent kinase (cGK I), angiotensin converting enzyme (ACE) and growth factor (GF) etc, has given the theoretical evidence for the clinical treatment of ED in future.
Qiao
Liang
L
Urology Institute of Peking University, Beijing 100034, China.
Xin
Zhong-Cheng
ZC
D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics; D016228:Endothelial Growth Factors / Q000235:genetics; D007172:Erectile Dysfunction / Q000235:genetics*; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008222:Lymphokines / Q000235:genetics; D008297:Male; D019001:Nitric Oxide Synthase / Q000235:genetics; D010410:Penile Erection / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D010727:Phosphoric Diester Hydrolases / Q000235:genetics; D015221:Potassium Channels / Q000235:genetics; D013002:Somatomedins / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D015221:Potassium Channels; D013002:Somatomedins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D019001:Nitric Oxide Synthase; D006419:Heme Oxygenase (Decyclizing); D017869:Cyclic GMP-Dependent Protein Kinases; D010727:Phosphoric Diester Hydrolases; D007703:Peptidyl-Dipeptidase A