Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression.
The insulin-like growth factor-I receptor (IGF-IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF-IR signaling has been implicated in the development of different types of tumors. The strong antiapoptotic activity of IGF-IR has been recognized as critical in IGF-I-dependent tumorigenesis, however, the impact of other IGF-IR functions, such as regulation of cell-cell and cell-matrix adhesion are also increasingly acknowledged. Here, on the model of breast cancer cells, we discuss how IGF-IR-dependent regulation of intercellular adhesion may affect cell survival, resistance to antiestrogens, and invasion.
Mauro
Loredana
L
Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Salerno
Michele
M
Morelli
Catia
C
Boterberg
Tom
T
Bracke
Marc E
ME
Surmacz
Eva
E
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002468:Cell Physiological Phenomena; D018450:Disease Progression; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D017526:Receptor, IGF Type 1 / Q000502:physiology*
D015820:Cadherins; D017526:Receptor, IGF Type 1