[Correlation between exon5 polymorphism of glutathione S-transferase P1 gene and susceptibility to chronic obstructive pulmonary disease in northern Chinese population of Han nationality living in Beijing, China].
OBJECTIVE
This research aimed to investigate the correlation between glutathione S-transferase P1 (GSTP1) gene exon5 A/G polymorphism and chronic obstructive pulmonary disease (COPD) susceptibility in northern Chinese population of Han nationality living in Beijing.


METHODS
The genotypes of 97 COPD patients and 67 smoking control subjects without COPD were determined by polymerase chain reaction followed by restriction fragment length polymorphism for the GSTP1 gene exon5.


RESULTS
No significant differences were observed in the frequencies of polymorphic genotypes in exon5 of GSTP1 gene between COPD patients and control smokers (genotype frequency: AA: 72% vs 61%; AG: 23% vs 36%; GG: 5% vs 3%; P > 0.05). The allele frequencies were also not significantly different between two groups (A allele frequency: 84% vs 79%, P > 0.05; G allele frequency: 16% vs 21%; P > 0.05). There were no significant differences in the frequencies of polymorphic genotypes and allele of GSTP1 between the male COPD patients and male control smokers.


CONCLUSIONS
The genetic polymorphism in GSTP1 gene exon5 was not associated with the susceptibility to COPD in northern Chinese population of Han nationality.
Lu
Bingbing
B
Department of Pulmonary Medicine, People's Hospital, Peking University, Beijing 100044, China.
He
Quanying
Q
D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D004198:Disease Susceptibility; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012907:Smoking / Q000235:genetics
D005982:Glutathione Transferase