title: Intravenous propofol in the treatment of refractory headache.
abstract: We analyzed the results of treating patients who had chronic daily headaches that were refractory to standard medications with repetitive low-dose boluses of intravenous propofol (2,6-diisopropylphenol). Patients were treated over a 1-year period at Thomas Jefferson University Hospital. A total of 18 patients were treated a total of 21 times. Over 90% of patients had at least some headache relief after treatment. The headache cycle was broken in eight patients. There were no complications. Intravenous propofol is safe and effective when used under monitored conditions and should be considered for patients who have refractory chronic daily headache and have failed other interventions.
authors.affiliation: Thomas Jefferson University Hospital, Jefferson Headache Center, Philadelphia, Pennsylvania 19107, USA.
authors.forename: Paula M
authors.initials: PM
authors.lastname: Mendes
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Silberstein
authors.forename: William B
authors.initials: WB
authors.lastname: Young
authors.forename: Todd D
authors.initials: TD
authors.lastname: Rozen
authors.forename: Mary F
authors.initials: MF
authors.lastname: Paolone
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D020773:Headache Disorders / Q000188:drug therapy*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008875:Middle Aged; D010148:Intractable Pain / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol