title: [A case of AFP-producing gastric cancer with multiple liver metastases responding to CPT-11 and cisplatin combination chemotherapy].
abstract: A case of AFP-producing gastric cancer successfully treated with CPT-11 and cisplatin combined therapy is reported together with a review of the literature. A 52-year-old male was admitted with complaints of upper abdominal pain and body weight loss. Gastric cancer with multiple liver metastases was diagnosed based on endoscopy and computed tomography findings. The patient's serum AFP level was 697,100 ng/ml and a biopsy specimen showed AFP-positive tumor cells immunohistochemically. He was treated with a combination chemotherapy consisting of CPT-11 (70 mg/m2) on day 1 and 15, and cisplatin (80 mg/m2) on day 1, repeated every 4 weeks. The primary lesion of the stomach and the liver metastases were remarkably reduced, and the serum level of AFP decreased to 18 ng/ml after 5 cycles of this treatment. No severe side effects were seen during this treatment. This result suggests that combination chemotherapy consisting of CPT-11 and cisplatin may be effective and safe for patients with AFP-producing gastric cancer with multiple liver metastases.
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Asami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kokawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sugimori
authors.forename: Naohiko
authors.initials: N
authors.lastname: Tomita
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Shirato
authors.forename: Manabu
authors.initials: M
authors.lastname: Morimoto
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Saito
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin