title: Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process.
abstract: [reaction: see text] The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14-C26 segment of halichondrins has been developed.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Hyeong-Wook
authors.initials: HW
authors.lastname: Choi
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakajima
authors.forename: Damtew
authors.initials: D
authors.lastname: Demeke
authors.forename: Fu-An
authors.initials: FA
authors.lastname: Kang
authors.forename: Hyuk-Sang
authors.initials: HS
authors.lastname: Jun
authors.forename: Zhao-Kui
authors.initials: ZK
authors.lastname: Wan
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kishi
mesh_terms: D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004988:Ethers, Cyclic; D002857:Chromium; D009532:Nickel