title: Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve.
abstract: Thiocolchicine is a colchicine-derivative used in the therapy of some diseases and extensively studied in the field of oncological research as antimitotic agent. Here we studied the activity of thiocolchicine on the cytoskeleton of the peroneus nerve, performing a histological and ultrastructural analysis. We observed a decrease in mean myelinated fiber area in thiocolchicine-treated rats in comparison to controls; this was due to a decrease in mean axoplasm area, while myelin thickness was constant. In the ultrastructural analysis a decrease in microtubule density and an increase in neurofilaments were found; moreover, the myelinated fibers seemed to be more affected in comparison to the unmyelinated axons. These findings are in agreement with the capability of binding to microtubule skeleton shared by all the colchicinoids.
authors.affiliation: Institute of Morphological Sciences, University of Urbino, Urbino, Italy. p.ferri@uniurb.it
authors.forename: Paola
authors.initials: P
authors.lastname: Ferri
authors.forename: Cesare
authors.initials: C
authors.lastname: Bruno
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cecchini
authors.forename: Sandra
authors.initials: S
authors.lastname: Ciaroni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ambrogini
authors.forename: Loretta
authors.initials: L
authors.lastname: Guidi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cuppini
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Morazzoni
authors.forename: Antonella
authors.initials: A
authors.lastname: Riva
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Grande
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D003078:Colchicine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003599:Cytoskeleton / Q000648:ultrastructure*; D007274:Injections, Intraperitoneal; D008297:Male; D008870:Microtubules / Q000648:ultrastructure; D009186:Myelin Sheath / Q000648:ultrastructure; D010543:Peroneal Nerve / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C014856:thiocholchicine; D003078:Colchicine