A MyoD-dependent differentiation checkpoint: ensuring genome integrity.
In a recent paper, the concept of a genotoxic stress-induced differentiation checkpoint has been proposed. The suggested function of this checkpoint is to preserve the integrity of the genome in terminally differentiated cells.
Polesskaya
Anna
A
Ottawa Health Research Institute, 501 Smyth Road, Ontario K1H 8L6, Canada.
Rudnicki
Michael A
MA
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics; D018816:Genes, cdc / Q000502:physiology*; D016678:Genome; D006801:Humans; D018482:Muscle, Skeletal / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D017570:MyoD Protein / Q000235:genetics* / Q000378:metabolism; D032448:Myoblasts, Skeletal / Q000166:cytology / Q000378:metabolism*
D017570:MyoD Protein