Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives.
2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.
Cointeaux
Laure
L
UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay Malabry Cedex, France.
Berrien
Jean-François
JF
Peyrou
Viviane
V
Provot
Olivier
O
Ciceron
Liliane
L
Danis
Martin
M
Robert
Anne
A
Meunier
Bernard
B
Mayrargue
Joëlle
J
D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008665:Metalloporphyrins / Q000737:chemistry; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry; D013329:Structure-Activity Relationship
D000962:Antimalarials; D037621:Artemisinins; D008665:Metalloporphyrins; D010545:Peroxides; D012717:Sesquiterpenes; C041471:manganese tetraphenylporphyrin; C031327:artemisinin