title: The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36.
abstract: Fatty acid translocase (FAT)/CD36 has been associated with diverse normal and pathologic processes. These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming growth factor-beta activation, atherosclerosis, diabetes and cardiomyopathy. Although CD36 was identified more than 25 years ago, it is only with the advent of recent genetic technology that in vivo evidence has emerged for its physiologic and pathologic relevance. As these in vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36.
authors.affiliation: Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021-4896, USA. mjfebbra@med.cornell.edu
authors.forename: M
authors.initials: M
authors.lastname: Febbraio
authors.forename: E
authors.initials: E
authors.lastname: Guy
authors.forename: C
authors.initials: C
authors.lastname: Coburn
authors.forename: F F
authors.initials: FF
authors.lastname: Knapp
authors.forename: A L
authors.initials: AL
authors.lastname: Beets
authors.forename: N A
authors.initials: NA
authors.lastname: Abumrad
authors.forename: R L
authors.initials: RL
authors.lastname: Silverstein
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism*
chemical_list: D018955:CD36 Antigens; D005227:Fatty Acids; D008562:Membrane Glycoproteins; D027361:Organic Anion Transporters