title: Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1.
abstract: Migraine is the most common type of chronic episodic headache. To find novel susceptibility genes for familial migraine with and without aura, a genomewide screen was performed in a large family from northern Sweden. Evidence of linkage was obtained on chromosome 6p12.2-p21.1, with a maximum two-point lod score of 5.41 for marker D6S452. The patients with migraine shared a common haplotype of 10 Mb between markers D6S1650 and D6S1960.
authors.affiliation: Umeå Centre for Molecular Medicine, University of Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Carlsson
authors.forename: L
authors.initials: L
authors.lastname: Forsgren
authors.forename: P-O
authors.initials: PO
authors.lastname: Nylander
authors.forename: U
authors.initials: U
authors.lastname: Hellman
authors.forename: K
authors.initials: K
authors.lastname: Forsman-Semb
authors.forename: G
authors.initials: G
authors.lastname: Holmgren
authors.forename: D
authors.initials: D
authors.lastname: Holmberg
authors.forename: M
authors.initials: M
authors.lastname: Holmberg
mesh_terms: D000328:Adult; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics* / Q000503:physiopathology; D020326:Migraine without Aura / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D013548:Sweden
chemical_list: D005819:Genetic Markers; D004247:DNA