title: Cascade synthesis with (triphenylphosphoranylidene)-ethenone as a versatile reagent for fast synthesis of heterocycles and unsaturated amides under microwave dielectric heating.
abstract: A general procedure for the synthesis of a large variety of compounds comprising an alpha, beta,-unsaturated carbonyl functionality was developed. The use of one-pot cascade synthesis with (triphenylphosphora-nylidene)ethenone as a versatile reagent for various formations including heterocycles of different ring sizes and unsaturated amides in combination with microwave dielectric heating is described. The method was used to synthesize a small library of unsaturated amides.
authors.affiliation: Personal Chemistry AB, Kungsgatan 76, Uppsala, SE-753 18, Sweden. jacob.westman@personalchemistry.com
authors.forename: J
authors.initials: J
authors.lastname: Westmana
authors.forename: K
authors.initials: K
authors.lastname: Orrling
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006358:Hot Temperature; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis; D008872:Microwaves; D009943:Organophosphorus Compounds / Q000737:chemistry
chemical_list: D000577:Amides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007659:Ketones; D009943:Organophosphorus Compounds