title: [Preventing of stroke by antihypertensive drugs: potential and limitations].
abstract: Analysis of controlled randomized studies of efficacy of antihypertensive drugs in primary and secondary prevention of stroke is presented. Basing on this analysis a conclusion is made that in patients with hypertension representatives of all 4 main classes of antihypertensive drugs prevent stroke with similar efficacy. Magnitude of reduction of risk of both first and recurrent stroke is determined not by the class of a drug but by degree of blood pressure lowering. Special emphasis is made on necessity of careful approach to blood pressure lowering in elderly patients.
authors.forename: D V
authors.initials: DV
authors.lastname: Preobrazhenskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Marenitch
authors.forename: I M
authors.initials: IM
authors.lastname: Shatunova
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000959:Antihypertensive Agents