title: Atypical form of active melorheostosis and its treatment with bisphosphonate.
abstract: We present the case of a 38-year-old man in whom extensive bilateral melorheostosis was associated with elevated serum alkaline phosphatase, swelling of the right foot and progressive deformity of the left hand, left leg and right foot. Radiography, computed tomography and bone scintigraphy were performed. Following treatment with bisphosphonate (30 mg/day of pamidronate for 6 days) infusion, the pain and swelling of his right foot showed improvement and his elevated serum alkaline phosphatase decreased.
authors.affiliation: National Institute of Rheumatology and Physiotherapy, 1027 Budapest, Hungary. orfireum@matavnet.hu
authors.forename: Judit
authors.initials: J
authors.lastname: Donáth
authors.forename: Gyula
authors.initials: G
authors.lastname: Poór
authors.forename: Csaba
authors.initials: C
authors.lastname: Kiss
authors.forename: Béla
authors.initials: B
authors.lastname: Fornet
authors.forename: Harry
authors.initials: H
authors.lastname: Genant
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005528:Foot; D006225:Hand; D006801:Humans; D007866:Leg; D008297:Male; D008557:Melorheostosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077268:Pamidronate; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate