Bell's palsy and herpesviruses.
A growing body of evidence links reactivation of herpesviruses (primarily varicella zoster virus and herpes simplex virus type 1) with the development of a large proportion of cases of acute peripheral facial palsy, a syndrome commonly known by its eponym, Bell's palsy. This article reviews the definition and natural history of the disease, its underlying anatomy and pathophysiology, the data linking herpetic reactivation with development of signs and symptoms, and therapeutic trials utilizing antiviral therapy. In addition, it poses the question, would earlier intervention with antivirals make a larger impact on outcomes?
Gilbert
Stan C
SC
Dermatology and Laser Center NW, 3614 Meridian Suite 200, Bellingham, WA 98225, USA. stangilb@aol.com
D020330:Bell Palsy / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D006564:Herpesviridae / Q000472:pathogenicity / Q000502:physiology; D006566:Herpesviridae Infections / Q000150:complications*; D006801:Humans