title: Ultrasound guided, pre-radiation oxygen measurements using polarographic oxygen needle electrodes in spontaneous canine soft tissue sarcomas.
abstract: BACKGROUND
  Poor tumour oxygenation is associated with radiation resistance. The recording of pre-treatment oxygenation status has been shown to be of prognostic relevance.
  
  
  METHODS
  Eleven dogs with spontaneously arising soft tissue sarcomas were included in this study. Oxygen partial pressure measurements (pO2) were performed with the Eppendorf method.
  
  
  RESULTS
  The mean of median pO2 was 9.6 mmHg (range: 0.1-30 mmHg). Four of the nine dogs included in the statistical analysis showed a median pO2 < or = 2.5 mmHg. The natural logarithm of the hypoxic subvolume correlated with the hypoxic fraction < or = 2.5 mmHg (p = 0.0712) and < or 5 mmHg (p = 0.0988). Mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) correlated significantly to several oxygen parameters.
  
  
  CONCLUSIONS
  Hypoxia exists in spontaneous canine soft tissue sarcomas and the dog can be used as a reliable model for repeated oxygenation measurements. Ultrasonography assures reliability of needle placement.
authors.affiliation: Section of Diagnostic Imaging and Radiation Oncology, Veterinary Hospital, University of Zurich, Zurich, Switzerland.
authors.forename: Roger
authors.initials: R
authors.lastname: Achermann
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ohlerth
authors.forename: Janean
authors.initials: J
authors.lastname: Fidel
authors.forename: Olivier
authors.initials: O
authors.lastname: Gardelle
authors.forename: Max
authors.initials: M
authors.lastname: Gassmann
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Roos
authors.forename: H Mark
authors.initials: HM
authors.lastname: Saunders
authors.forename: Annette
authors.initials: A
authors.lastname: Scheid
authors.forename: Melanie
authors.initials: M
authors.lastname: Wergin
authors.forename: Barbara
authors.initials: B
authors.lastname: Kaser-Hotz
mesh_terms: D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism* / Q000532:radiotherapy; D004285:Dogs; D017736:Ion-Selective Electrodes; D009367:Neoplasm Staging / Q000662:veterinary; D010100:Oxygen / Q000378:metabolism*; D011048:Polarography / Q000662:veterinary; D011379:Prognosis; D011878:Radiotherapy / Q000662:veterinary; D012509:Sarcoma / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D014463:Ultrasonography / Q000662:veterinary
chemical_list: D010100:Oxygen