Mechanisms of enveloped RNA virus budding.
To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. This new model of virus budding has many potential implications for cell biology and viral pathogenesis.
Pornillos
Owen
O
Dept of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.
Garrus
Jennifer E
JE
Sundquist
Wesley I
WI
D002462:Cell Membrane / Q000821:virology*; D022162:Cytoplasmic Vesicles / Q000821:virology; D006678:HIV / Q000254:growth & development; D006801:Humans; D018716:Molecular Mimicry; D021381:Protein Transport; D012328:RNA Viruses / Q000254:growth & development*; D019065:Virus Assembly