title: Vascular reserve in the lower limbs of cirrhotic patients: a duplex Doppler ultrasound study.
abstract: OBJECTIVE
  To evaluate femoral artery impedance at rest and during reactive hyperaemia.
  
  
  METHODS
  Study population comprised 11 cirrhotic patients without ascites, 10 with ascites and 16 age- and sex-matched healthy subjects.
  
  
  METHODS
  Echocardiographic assessment of systemic haemodynamics; duplex Doppler ultrasound measurement of femoral artery pulsatility index and vascular reserve [pulsatility index rest/pulsatility index hyperaemia).
  
  
  RESULTS
  Cirrhotic patients had elevated cardiac index and low systemic vascular resistance. Pulsatility index (right femoral artery) was not statistically different either at rest or after reactive hyperaemia (controls: rest 10.6 +/- 0.4, hyperaemia 2.6 +/- 0.2; compensated cirrhosis: rest 10.1 +/- 0.8, hyperaemia 3.4 +/- 0.4; ascitic cirrhosis: rest 11.4 +/- 1.6, hyperaemia 2.9 +/- 0.4. Vascular reserve was 4.38 +/- 0.35 in controls, 3.33 +/- 0.39 in compensated and 4.70 +/- 0.89 in ascitic cirrhosis (p = not significant). No correlation was found between systemic haemodynamic parameters and either pulsatility index or vascular reserve.
  
  
  CONCLUSIONS
  The lower limb vascular reserve is preserved in cirrhosis.
authors.affiliation: Department of Internal Medicine, University of Florence School of Medicine, Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: La Villa
authors.forename: G
authors.initials: G
authors.lastname: Barletta
authors.forename: D
authors.initials: D
authors.lastname: Righi
authors.forename: M
authors.initials: M
authors.lastname: Foschi
authors.forename: R
authors.initials: R
authors.lastname: Del Bene
authors.forename: R
authors.initials: R
authors.lastname: Tarquini
authors.forename: P
authors.initials: P
authors.lastname: Pantaleo
authors.forename: P
authors.initials: P
authors.lastname: Gentilini
authors.forename: G
authors.initials: G
authors.lastname: Laffi
mesh_terms: D000368:Aged; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance