title: Dorsal skin responses to topical application with hydrogen peroxide in Mini and Wistar rats.
abstract: Mini rats (Jcl: WistarTGN(ARGHGEN) 1Nts) (MRs) are Wistar rat (WR)-derived transgenic rats in which the expression of growth hormone (GH) gene is suppressed under the presence of antisense RNA transgene. In order to evaluate the effects of GH-deficiency on the acute injury by external stimuli, the dorsal skin responses to a single topical application with 20% hydrogen peroxide (HPO), one of the environmental oxidative stressors, were histologically compared between male MRs and WRs of 8 weeks old, whose hair cycle was under the telogen phase. As a result, formation of granulation tissues, reepithelialization and regrowth of hair follicles were delayed in MRs compared with WRs. While hair follicles of MRs of this age are under a long-lasting telogen phase after their 2nd cycle, a new hair cycle started not only in the HPO-applied area but also in the solvent-applied area with a little time lag. These findings suggest that GH-deficiency may influence the skin responses to the external chemical stimuli.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. akunio@mail.ecc.u-tokyo.ac.jp
authors.forename: Aya
authors.initials: A
authors.lastname: Umeda-Ikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishii
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Koji
authors.initials: K
authors.lastname: Uetsuka
authors.forename: Hjroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D013006:Growth Hormone / Q000172:deficiency*; D006861:Hydrogen Peroxide / Q000633:toxicity*; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D013006:Growth Hormone; D006861:Hydrogen Peroxide