Effect of butanolic fraction of Desmodium adscendens on the anococcygeus of the rat.
The chemical composition of plants can vary according to factors such as soil and time of collection. Desmodium adscendens (Sw.) D.C. var. adscendens (Papillionaceae) is a plant employed in the treatment of asthma in Ghana, Africa. Studies have shown that butanolic extract inhibits contraction of the ileum and trachea in guinea pigs. In Mato Grosso, this plant is used only in the treatment of ovarian inflammation. The objective of this work was to verify if the plant found in Mato Grosso also relaxes smooth muscle and to understand better its action. The cumulative application of the butanolic fraction relaxed the contraction maintained in the isolated anococcygeus of a rat, induced by high potassium, but not that induced by phenylephrine. Relaxation was not altered by methylene blue. The butanolic fraction reduced in a concentration-dependent way the maximum response of concentration-response curve to calcium in the anococcygeus muscle. The results suggest that the butanolic fraction acts, at least partly, through the blockade of voltage-sensitive Ca+2 channels.
Barreto
G S
GS
Department of Basic Health Sciences, Universidade Federal de Mato Grosso, Av. Fernando Corrêa Costa, s/n, CEP 78060-900, Coxipó, Cuiabá, MT, Brazil. genesson@cpd.ufmt.br
D020001:1-Butanol / Q000302:isolation & purification / Q000494:pharmacology*; D001003:Anal Canal / Q000187:drug effects / Q000502:physiology; D000818:Animals; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012445:Sacrococcygeal Region
D010936:Plant Extracts; D020001:1-Butanol