title: Fibrinogen: intra-individual variability in patients with arterial disease and in patients with cardiac valve replacements.
abstract: BACKGROUND
  Elevated fibrinogen, considered an independent risk factor for coronary disease, stratifies an individual as high risk for coronary disease. A risk marker requires little intra-individual variability during a long period.
  
  
  OBJECTIVE
  To establish intra-individual variability of fibrinogen levels in patients with coronary disease.
  
  
  METHODS
  We investigated fibrinogen levels prospectively in four blood samples drawn from 267 patients with a history of arterial disease (arterial group) and from 264 patients with cardiac valve replacements (valvular group). The samples were taken during the course of 78.7 and 78.8 days from the arterial and valvular groups respectively.
  
  
  RESULTS
  Marked intra-individual dispersion with a reliability coefficient of 0.541 was found in the arterial group and 0.547 in the valvular group. The Bland-Altman test showed low probability to obtain similar results in different samples from the same individual. These results show large intra-individual variability, with similarities in the arterial as well as in the valvular group.
  
  
  CONCLUSIONS
  It is not possible to stratify a patient by a specific fibrinogen dosage.
authors.affiliation: Buenos Aires Thrombosis Center, Buenos Aires, Argentina. rouviermed@hotmail.com
authors.forename: Jorge
authors.initials: J
authors.lastname: Rouvier
authors.forename: Claudio
authors.initials: C
authors.lastname: González
authors.forename: Alejandra
authors.initials: A
authors.lastname: Scazziota
authors.forename: Raúl
authors.initials: R
authors.lastname: Altman
mesh_terms: D000704:Analysis of Variance; D003327:Coronary Disease / Q000097:blood*; D005340:Fibrinogen / Q000378:metabolism*; D006350:Heart Valve Prosthesis; D006801:Humans; D011446:Prospective Studies
chemical_list: D005340:Fibrinogen