Effect of conformational preorganization of a three-armed host on anion binding and selectivity.
A set of three-armed urea-containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganization with respect to the arrangement of the side-arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride/nitrate-selectivity.
Hettche
Frank
F
Fachbereich Chemie der Philips Universität Marburg, Hans Meerwein Strasse, Germany.
Beiss
Philipp
P
Hoffmann
Reinhard W
RW
D000838:Anions / Q000737:chemistry*; D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry; D008968:Molecular Conformation; D009566:Nitrates / Q000737:chemistry; D012680:Sensitivity and Specificity; D014227:Triazines / Q000737:chemistry*
D000838:Anions; D002712:Chlorides; D009566:Nitrates; D014227:Triazines