title: The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation.
abstract: Certain cytokine gene polymorphisms may be associated with severe acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. The present study analysed 196 patients and their donors for TNF-308, TNFd, IL-10-1064 and IL-10-1082 gene polymorphisms. Serum analysis of tumour necrosis factor-alpha (TNF-alpha) and interleukin 10 (IL-10) levels during conditioning therapy was also performed. Among patients with sibling donors, the TNFd allele 4 was significantly correlated with acute GVHD grades II-IV (P < 0.01). Acute GVHD grades II-IV were more common among patients homozygous for the IL-10-1064 allele 13 (P = 0.02). Patients homozygous for the TNF-308 allele (AA) correlated with higher TNF-alpha serum levels during conditioning (P = 0.02).
authors.affiliation: Department of Clinical Immunology, and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Nordlander
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uzunel
authors.forename: Jonas
authors.initials: J
authors.lastname: Mattsson
authors.forename: Mats
authors.initials: M
authors.lastname: Remberger
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019172:Transplantation Conditioning / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10