[Neurotrophin-like low molecular weight compounds].
A large number of compounds have been reported to prevent ischemia-induced neuronal death, whereas there are few described to enhance recovery of brain functions. Since neurotrophins do not only prevent neuronal death but also protect neuronal circuits, they may be potential candidates. However, their poor penetration of the blood-brain-barrier hampers their development as therapeutic agents. In this context, low-molecular-weight compounds that possess neurite outgrowth- and neuronal survival-promoting activities may be alternative candidates. Neurite outgrowth-promoting prostaglandins, which were recently-synthesized based on the chemical structure of anti-tumor cyclopentenone prostaglandin derivatives, have been characterized by their neurotrophic effects on neurons in the central nervous system. In this paper, we present a review of these compounds as therapeutic agents against several neurodegenerative diseases.
Satoh
Takumi
T
Department of Welfare Engineering, Faculty of Engineering, Iwate University, 4-3-5 Ueda, Morioka-shi, Iwate 020-8551, Japan. tsatoh@iwate-u.ac.jp
D000818:Animals; D015230:Prostaglandin D2 / Q000031:analogs & derivatives; D011453:Prostaglandins / Q000737:chemistry / Q000494:pharmacology*
C424427:NEPP11 compound; D011453:Prostaglandins; D015230:Prostaglandin D2