Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Camptothecin consists of a lactone E ring adjacent to tetracyclic A-D rings of a planar chromophore, which are essential for topoisomerase I inhibition and DNA interaction. The A-D rings can be exploited to develop DNA-sequence-reading molecules. Indolizino[1,2-b]quinoline derivatives substituted with a piperidinoethyloxy side chain and an aminomethyl function on rings A and D, respectively, were synthesized, and their DNA binding and formaldehyde-mediated bonding properties were investigated.
Perzyna
Aurore
A
Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille 2, BP 83, 59006 Lille, France.
Marty
Carine
C
Facompré
Michael
M
Goossens
Jean-François
JF
Pommery
Nicole
N
Colson
Pierre
P
Houssier
Claude
C
Houssin
Raymond
R
Hénichart
Jean-Pierre
JP
Bailly
Christian
C
D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry*
D003432:Cross-Linking Reagents; D005557:Formaldehyde; D004247:DNA; D003850:Deoxyribonuclease I; D002166:Camptothecin