title: [Clinical trial of lentaron for postmenopausal patients with advanced breast cancer].
abstract: OBJECTIVE
  To evaluate the efficacy and adverse effects of lentaron for postmenopausal patients with recurrent and metastatic breast cancer.
  
  
  METHODS
  Thirty-four patients with recurrent and metastatic breast cancer received 250 mg lentaron by intramuscular injection every 2 weeks for at least one month.
  
  
  RESULTS
  In 34 patients who were evaluable for efficacy and toxicity, the complete response rate (CR), partial response rate (PR), disease stabilization rate (SD) and progressive disease rate (PD) were 0%, 14.7%, 58.8% and 26.5%. The clinical benefit rate (CR + PR + SD >/= 6 months) was 50.0%. (17/34) with 12 patients (35.3%) having SD for at least 6 months. The response rates for bone, soft tissue and visceral metastasis were 28.6% (3/14), 13.6% (3/22) and 5.3% (1/19), respectively. There were no severe adverse effects in the treatment bylentaron.
  
  
  CONCLUSIONS
  Lentaron is a well tolerated agent with reasonable efficacy but low toxicity for postmenopausal patients with recurrent and metastatic breast cancer.
authors.affiliation: Department of Breast Cancer, 307 Hospital, Academy of Military Medical Sciences, Beijing 100039, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
authors.forename: Santai
authors.initials: S
authors.lastname: Song
authors.forename: Zefei
authors.initials: Z
authors.lastname: Jiang
authors.forename: Shikai
authors.initials: S
authors.lastname: Wu
authors.forename: Jingxin
authors.initials: J
authors.lastname: Yu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000735:Androstenedione / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D017698:Postmenopause; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000735:Androstenedione; C014594:formestane