title: Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract.
abstract: Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o. and its fractions at 25 mg kg(-1) and 50 mg kg(-1), p.o. showed the significant dose dependent antiinflammatory activity in carrageenan and dextran-induced rats hind paw edema (acute models) as well as in cotton pellet-induced granuloma (chronic model) in rats. Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg kg(-1)).
authors.affiliation: ICMR Virus Unit Calcutta, I.D. & B.G. Hospital, Beliaghata, Kolkata, India.
authors.forename: G
authors.initials: G
authors.lastname: Arunachalam
authors.forename: D
authors.initials: D
authors.lastname: Chattopadhyay
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: A B
authors.initials: AB
authors.lastname: Mandal
authors.forename: T K
authors.initials: TK
authors.lastname: Sur
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000208:Acute Disease; D031051:Alstonia; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan / Q000008:administration & dosage; D002908:Chronic Disease; D003911:Dextrans / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D006614:Hindlimb / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010936:Plant Extracts; D002351:Carrageenan; D007213:Indomethacin