Regulation of chemokine expression in atherosclerosis.
(1) Chemokines play a central role in the pathogenesis of atherosclerosis, contributing to leukocyte recruitment, angiogenesis and also proliferation and migration of smooth muscle cells into atherosclerotic plaques. (2) Leukocytes and endothelial cells are an important source of chemokines, and many of the risk factors associated with atherosclerosis increase chemokine expression. There is now a body of evidence to suggest that interactions between cells such as leukocytes and endothelial cells amplify chemokine release, and this may contribute to sustained chemokine generation in inflammatory conditions. (3) This article summarises, briefly, what is currently known about chemokines release. A number of important pharmacological strategies used in the treatment of atherosclerosis inhibit chemokine release and the extent to which this may contribute to their therapeutic effect will be discussed. Understanding the mechanisms controlling chemokine expression is essential for the design of specific therapeutic interventions in atherosclerosis.
Burke-Gaffney
Anne
A
Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK. a.burke-gaffney@ic.ac.uk
Brooks
Alison V S
AV
Bogle
Richard G
RG
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002450:Cell Communication / Q000502:physiology; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D019707:Receptors, Chemokine / Q000096:biosynthesis / Q000502:physiology
D018925:Chemokines; D019707:Receptors, Chemokine