title: Drugs targeting functional bowel disorders: insights from animal studies.
abstract: Increased understanding of gastrointestinal pathophysiology in functional bowel disorders is leading to improved focus on relevant enteric, vagal and spinal afferent nervous systems, and targets operating on these systems. These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing factor and somatostatin.
authors.affiliation: Neurology and Gastroenterology-CEDD, GlaxoSmithKline, Harlow, Essex, UK. Gareth_J_Sanger@gsk.com
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Sanger
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Hicks
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D010146:Pain / Q000188:drug therapy
chemical_list: D005765:Gastrointestinal Agents