The on-off story of protein palmitoylation.
Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.
Bijlmakers
Marie-José
MJ
Peter Gorer Department of Immunobiology, Kings College London, 3rd Floor New Guy's House, Guy's Hospital, London SE1 9RT, UK. marie.bijlmakers@kcl.ac.uk
Marsh
Mark
M
D000595:Amino Acid Sequence / Q000502:physiology; D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010168:Palmitates / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D008565:Membrane Proteins; D010168:Palmitates; D011506:Proteins