Severe Legionella pneumophila pneumonia in a patient with iron overload.
Iron plays a crucial role in the energy metabolism of microorganisms. Humans have developed iron-withholding mechanisms as a form of non-specific immunity. We describe a patient with iron overload and severe Legionella pneumophila pneumonia. This report emphasizes the importance of early consideration of and appropriate therapy against Legionella for patients with iron overload who present with community-acquired pneumonia.
Vikram
Holenarasipur R
HR
Department of Medicine, Section of Infectious Diseases, Hospital of St. Raphael, Yale University School of Medicine, New Haven, Connecticut 06511, USA. hvikram@srhs.org
Bia
Frank J
FJ
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D019190:Iron Overload / Q000150:complications* / Q000175:diagnosis; D016952:Legionella pneumophila / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology; D012121:Respiration, Artificial; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents