Syntheses of novel substituted-boranophosphate nucleosides.
A number of substituted (borano) nucleic acids, 3'-[diethylphosphite(cyano, carboxy, or carbamoyl) borano] deoxynucleosides (3a-4c) and 5'-[diethylphosphite(cyano or carboxy) borano] deoxynucleosides (6a-7d) were prepared by a variety of synthetic procedures. The syntheses of the pyrophosphates (2a-2c), as precursors for 3a-4c, are also described.
Vyakaranam
Kamesh
K
Department of Chemistry and Biochemistry, Michael Faraday Laboratories, Northern Illinois University, DeKalb, IL 60115, USA.
Rana
Geeta
G
Spielvogel
Bernard F
BF
Maguire
John A
JA
Hosmane
Narayan S
NS
D001896:Boron Compounds / Q000138:chemical synthesis*; D003839:Deoxyadenosines / Q000138:chemical synthesis; D003841:Deoxycytidine / Q000138:chemical synthesis; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*
D001896:Boron Compounds; D003839:Deoxyadenosines; D009705:Nucleosides; D009943:Organophosphorus Compounds; D003841:Deoxycytidine