title: [Hepatic metastases from alpha-fetoprotein producing colorectal cancer that responded remarkably to transcatheter arterial chemo-embolization].
abstract: Although alpha-fetoprotein (AFP)-producing colorectal cancer is extremely rare, its potential for liver metastasis is high and the prognosis of the patient is very poor. We report a case of metastatic liver tumor from an AFP producing sigmoid colon cancer that was successfully treated with transcatheter arterial chemo-embolization (TACE). A 48-year-old female was admitted to our hospital complaining of anal bleeding, and was diagnosed as harboring a type 2 advanced tumor with two metastatic lesions in the lateral segment of the liver. Serum AFP measured 948.2 ng/ml before surgery. We performed sigmoidectomy and lateral segmentectomy of the liver. Pathological examination revealed moderately differentiated adenocarcinoma both in the primary and the metastatic lesions, and AFP-stain positive nests were seen on immunohistochemical staining. The serum AFP value returned to normal soon after the surgery. Five months later, a recurrent lesion was discovered in the right lobe of liver, and it was surgically removed. Another 4 months later, multiple liver metastases were recognized and the patient's serum AFP level was found to be 593.3 ng/ml. For the re-recurrent hepatic lesions of 5.5 cm in diameter, she underwent two courses of TACE using Lipiodol and epirubicin hydrochloride. Following the treatment, the tumor shrank rapidly and almost disappeared. The patient has been in good health for 24 months since the last TACE, and the serum AFP level has been within the normal range.
authors.affiliation: Dept. of Surgery, Tochigi Cancer Center.
authors.forename: Michiko
authors.initials: M
authors.lastname: Harao
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kotake
authors.forename: Kenji
authors.initials: K
authors.lastname: Kojima
authors.forename: Osamu
authors.initials: O
authors.lastname: Jindou
authors.forename: Masami
authors.initials: M
authors.lastname: Ishihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsui
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hishinuma
authors.forename: Takanobu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Takeo
authors.initials: T
authors.lastname: Tsukioka
authors.forename: Seiji
authors.initials: S
authors.lastname: Igarashi
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D016461:Chemoembolization, Therapeutic; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000903:Antibiotics, Antineoplastic; D000509:alpha-Fetoproteins; D015251:Epirubicin; D007459:Iodized Oil