A long-term perspective on the protective effects of an early invasive strategy in unstable coronary artery disease: two-year follow-up of the FRISC-II invasive study.
OBJECTIVE
We sought to report the first and repeat events and to separate spontaneous and procedure-related events over two years in the Fast Revascularization during InStability in Coronary artery disease (FRISC-II) invasive trial.


BACKGROUND
The FRISC-II invasive trial compared the long-term effects of an early invasive versus noninvasive strategy, in terms of death and myocardial infarction (MI) and the need for repeat hospital admissions and late revascularization procedures in patients with coronary artery disease (UCAD).


METHODS
In the FRISC-II trial, 2,457 patients with UCAD were randomized to an early invasive or noninvasive strategy.


RESULTS
At 24 month follow-up, there were reductions in mortality (n = 45 [3.7%] vs. 67 [5.4%]; risk ratio 0.68 [95% confidence interval (CI) 0.47 to 0.98]; p = 0.038), MI (n = 111 [9.2%] vs. 156 [12.7%]; risk ratio 0.72 [95% CI 0.57 to 0.91]; p = 0.005), and the composite end point of death or MI (n = 146 [12.1%] vs. 200 [16.3%]; risk ratio 0.74 [95% CI 0.61 to 0.90]; p = 0.003) in the invasive compared with the noninvasive group. Procedure-related MIs were two to three times more common, but spontaneous ones were three times less common in the invasive than in the noninvasive group. After the first year, there was no difference in mortality (n = 20 [1.7%]) between the two groups and fewer MIs in the invasive group (p = 0.031).


CONCLUSIONS
In UCAD, the early invasive approach leads to a sustained reduction in mortality, cardiac morbidity, and the need for repeat hospital admissions and late revascularization procedures. Although the benefits are greatest during the first months, during the second year, cardiac morbidity is lower and the need for hospital care is less in the invasive group.
Lagerqvist
Bo
B
Department of Cardiology, University Hospital, Uppsala, Sweden. bo.lagerqvist@card.uas.lul.se
Husted
Steen
S
Kontny
Fredrik
F
Näslund
Ulf
U
Ståhle
Elisabeth
E
Swahn
Eva
E
Wallentin
Lars
L
D000368:Aged; D000789:Angina, Unstable / Q000150:complications / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000150:complications / Q000401:mortality* / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000517:prevention & control; D009204:Myocardial Revascularization; D010359:Patient Readmission; D011446:Prospective Studies; D012008:Recurrence; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D016019:Survival Analysis; D013995:Time; D013997:Time Factors; D016896:Treatment Outcome