Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.
Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.
Patch
James A
JA
Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Barron
Annelise E
AE
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D015696:Gene Products, tat / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D023181:Antimicrobial Cationic Peptides; D015696:Gene Products, tat; D009842:Oligopeptides