title: A new 1,1'-binaphthyl-based catalyst for the enantioselective phenylacetylene addition to aromatic aldehydes without using a titanium complex.
abstract: [reaction: see text] A novel 1,1'-binaphthyl compound containing bulky 3,3'-aryl substituents is found to catalyze the reaction of a terminal alkyne with various aromatic aldehydes under mild conditions to generate chiral propargyl alcohols with 80-94% ee. Unlike the previously reported 1,1'-binaphthyl catalysts, this new compound does not require the use of a titanium complex and the pre-preparation of an alkynylzinc. This has greatly simplified the experimental procedure for this reaction.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville 22904-4319, USA.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Pu