title: Gene expression levels in different stages of progression in oral squamous cell carcinoma.
abstract: Oral squamous cell carcinoma (OSCC) is one of the most common cancer types worldwide. The prognosis for patients with this disease is generally poor and little is known about its progression. Gene expression studies may provide important insights to the molecular mechanisms of this disease. We analyzed gene expression data from a small panel of patients diagnosed with OSCC. Even with only 13 patient samples we were able to find genes with significant differences in expression levels between normal, dysplasia, and cancer samples. The largest differences in expression were generally found between normal and cancer samples, but significant differences were also found for several genes between dysplasia and the other two sample types. We also represent the significance levels of differentially expressed genes on the chromosome domain. The genes and genetic features we examine are potentially important factors on the molecular level in the progression of OSCC.
authors.affiliation: Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
authors.forename: Winston Patrick
authors.initials: WP
authors.lastname: Kuo
authors.forename: Tor-Kristian
authors.initials: TK
authors.lastname: Jenssen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Park
authors.forename: Mark W
authors.initials: MW
authors.lastname: Lingen
authors.forename: Rifat
authors.initials: R
authors.lastname: Hasina
authors.forename: Lucila
authors.initials: L
authors.lastname: Ohno-Machado
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging