Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.
Ernst
Justin T
JT
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA.
Kutzki
Olaf
O
Debnath
Asim K
AK
Jiang
Shibo
S
Lu
Hong
H
Hamilton
Andrew D
AD
D000595:Amino Acid Sequence; D002462:Cell Membrane; D002942:Circular Dichroism; D015195:Drug Design; D004797:Enzyme-Linked Immunosorbent Assay; D015700:HIV Envelope Protein gp41 / Q000737:chemistry* / Q000378:metabolism; D023581:HIV Fusion Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D008561:Membrane Fusion / Q000187:drug effects*; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*
D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010455:Peptides