title: Ultrasound biomicroscopy images: long-term results after deep sclerectomy with collagen implant.
abstract: OBJECTIVE
  The aim of this study was to understand the long-term outflow pathway mechanisms after deep sclerectomy - when collagen implant is resorbed - using ultrasound biomicroscopy (UBM).
  
  
  METHODS
  Forty-three eyes of 32 patients with medically uncontrolled open-angle glaucoma at least 1 year after deep sclerectomy were studied in an observational, non-randomised, consecutive case series. Postoperatively 15 eyes (35.7%) had goniopuncture with the Nd:YAG laser. Four eyes (9.5%) had postoperative subconjunctival injections of mitomycin C and two eyes (4.7%) had an injection of 5-fluorouracil, because of intraocular pressure (IOP) increase. Complete examination and UBM of the filtering site were performed 1-6 years after surgery. The following parameters were assessed: (1) Presence of a subconjunctival filtering bleb; (2) presence and volume of an intrascleral cavity; (3) presence of a suprachoroidal hypoechoic area.
  
  
  RESULTS
  Intraocular pressure decreased significantly from 28.1+/-2.5 mmHg preoperatively to 12.4+/-3.8 (range 7-25) mmHg at the time of UBM (at least 1 year after surgery). Forty eyes showed clinically a diffuse filtering bleb. UBM demonstrated a subconjunctival space in all eyes. In 39 eyes (92.8%) an intrascleral cavity was observed. The mean volume of this cavity was 1.8 (range 0.11-6.53) mm(3). In 19 eyes (45.2%) we observed a hypoechoic area in the suprachoroidal space.
  
  
  CONCLUSIONS
  UBM examination demonstrated several aqueous humour drainage pathways. A low-reflective diffuse subconjunctival space meant persistent filtration in all eyes. More than 1 year after surgery 92.8% of eyes had a remaining intrascleral cavity. In almost half of the patients an additional suprachoroidal outflow was observed, significantly correlated with a lower IOP.
authors.affiliation: Glaucoma Department, University Eye Hospital Jules Gonin, University of Lausanne, Switzerland. dida_kazakova@hotmail.com
authors.forename: Dida
authors.initials: D
authors.lastname: Kazakova
authors.forename: Sigrid
authors.initials: S
authors.lastname: Roters
authors.forename: Corinne C
authors.initials: CC
authors.lastname: Schnyder
authors.forename: Farid
authors.initials: F
authors.lastname: Achache
authors.forename: Christian
authors.initials: C
authors.lastname: Jonescu-Cuypers
authors.forename: André
authors.initials: A
authors.lastname: Mermoud
authors.forename: Günter
authors.initials: G
authors.lastname: Krieglstein
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000502:physiology; D003094:Collagen; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012590:Sclera / Q000000981:diagnostic imaging; D012599:Sclerostomy; D014463:Ultrasonography
chemical_list: D003094:Collagen