title: [A patient of ADEM with central and peripheral conduction block improved with ultra-high-dose methylprednisolone].
abstract: A patient with exanthem and fever showed progressive disturbance of consciousness and flaccid quadriplegia predominantly in the lower extremities. Antibiotics, aciclovir, high-dose methylprednisolone (1 g/day for 3 consecutive days) and IVIG (400 mg/kg/day for 5 consecutive days) were not effective. Nerve conduction study and SEP in the lower extremities showed peripheral and central conduction block. EEG showed irregular sharp and slow waves predominantly in the left hemisphere. ABR and SEP in the upper extremities were normal. Consecutive studies of cranial and spinal MRIs showed no abnormalities. A diagnosis of acute disseminated encephalomyelitis (ADEM) was made. We started administration of ultra-high-dose methylprednisolone (5.4 mg/kg/h for 47 hours), the dose for acute spinal cord injury based on the randomized controlled trial of The Third National Acute Spinal Cord Injury Study in the USA. After this, she regained consciousness and the quadriplegia improved. The abnormalities in the electrophysiological studies also normalized. It is thought that the neuroprotective mechanism of ultra-high-dose methylprednisolone could be attributed to its inhibition of lipid peroxidation, secondary, ischemia, energy failure and so on. If the usual treatment is not effective for severe encephalomyelitis cases, we can consider the administration of ultra-high-dose methylprednisolone as one of the new treatment options.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University School of Medicine.
authors.forename: Akiko
authors.initials: A
authors.lastname: Uehara
authors.forename: Yuhji
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nishitarumizu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Uto
authors.forename: Ryuhji
authors.initials: R
authors.lastname: Kubota
authors.forename: Manabu
authors.initials: M
authors.lastname: Johnosono
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Eiraku
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000209:etiology*; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage*; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000209:etiology*
chemical_list: D008775:Methylprednisolone