title: A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.
abstract: Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as lumbago, rheumatism and to reduce fever. Six isoquinoline alkaloids namely berberine, berbamine, palmatine, oxyacanthine, magnoflorine, and columbamine were isolated as the main components of alkaloidal fraction from the roots of Turkish Berberis species and effects were studied using various in vivo models in mice. All alkaloids inhibited inflammations in varying degrees, among them berberine, berbamine and palmatine were shown to possess significant and dose-dependent inhibitory activity against serotonin-induced hind paw oedema both on oral and topical applications and acetic acid-induced increase in vascular permeability on oral administration. Moreover, these three alkaloids were also shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration. However, all alkaloids induced gastric lesions in varying degrees.
authors.affiliation: Gazi University, Faculty of Pharmacy, Etiler 06330, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli
authors.forename: Müberra
authors.initials: M
authors.lastname: Koşar
authors.forename: Erdem
authors.initials: E
authors.lastname: Yeşilada
authors.forename: K
authors.initials: K
authors.lastname: Hüsnü
authors.forename: C
authors.initials: C
authors.lastname: Başer
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D028142:Berberis; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010147:Pain Measurement; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D018675:Toxicity Tests
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D001600:Berberine Alkaloids; D007546:Isoquinolines; D010936:Plant Extracts; C039109:isoquinoline