Synthesis of the C20-C26 building block of halichondrins via a regiospecific and stereoselective S(N)2' reaction.
[reaction: see text] A regiospecific and stereoselective S(N)2' reaction to convert the trisylate into the vinyl iodide is presented. The homoallylic alcohol is used to direct the delivery of LiCu(Me)(2).
Xie
Chaoyu
C
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Nowak
Pawel
P
Kishi
Yoshito
Y
D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D004988:Ethers, Cyclic