title: Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalities.
abstract: Good patient outcomes depend on the rapidity and completeness with which re-establishment of arterial blood flow to the limbs occurs. Patients with a greater magnitude of ischemic tissue--such as with an acute aortic occlusion--have worse outcomes than patients with a segmental artery occlusion such as a popliteal arterial thrombosis. Limb loss is high in any situation in which a delay in diagnosis occurs. It is unclear whether or not endovascular therapy will supercede traditional surgery because the etiologies of ALI are too broad to make sweeping conclusions at this time. The author and others [14,15], including those who have promulgated the use of thrombolytic therapy, have come to reasonable conclusions regarding how to deal with ALI: The diagnosis of ALI should be established rapidly. Determine its classification based on the patient's history and physical examination, and promptly institute anticoagulant therapy. Determine whether or not the patient should be taken emergently for surgical thromboembolectomy or a revascularization procedure versus arteriogram and possible thrombolysis. Adjunctive therapy such as antiplatelet agents (e.g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life.
authors.affiliation: Section of Vascular Surgery, University of Michigan, 2210D THCC, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0329, USA. henke@umich.edu
authors.forename: Peter K
authors.initials: PK
authors.lastname: Henke
mesh_terms: D000208:Acute Disease; D001132:Arm / Q000098:blood supply*; D006083:Graft Occlusion, Vascular / Q000628:therapy; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D017131:Thrombectomy / Q000379:methods; D015912:Thrombolytic Therapy / Q000379:methods