Modulation of the auditory cortex during speech: an MEG study.
Several behavioral and brain imaging studies have demonstrated a significant interaction between speech perception and speech production. In this study, auditory cortical responses to speech were examined during self-production and feedback alteration. Magnetic field recordings were obtained from both hemispheres in subjects who spoke while hearing controlled acoustic versions of their speech feedback via earphones. These responses were compared to recordings made while subjects listened to a tape playback of their production. The amplitude of tape playback was adjusted to match the amplitude of self-produced speech. Recordings of evoked responses to both self-produced and tape-recorded speech were obtained free of movement-related artifacts. Responses to self-produced speech were weaker than were responses to tape-recorded speech. Responses to tones were also weaker during speech production, when compared with responses to tones recorded in the presence of speech from tape playback. However, responses evoked by gated noise stimuli did not differ for recordings made during self-produced speech versus recordings made during tape-recorded speech playback. These data suggest that during speech production, the auditory cortex (1) attenuates its sensitivity and (2) modulates its activity as a function of the expected acoustic feedback.
Houde
John F
JF
Center for Integrative Neuroscience, University of California, San Francisco 94143, USA. houde@phy.ucsf.edu
Nagarajan
Srikantan S
SS
Sekihara
Kensuke
K
Merzenich
Michael M
MM
D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D005246:Feedback; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013060:Speech / Q000502:physiology*; D013067:Speech Perception / Q000502:physiology*