title: The dentino-enamel junction revisited.
abstract: The dentino-enamel junction is not an simple inert interface between two mineralized structures. A less simplistic view suggests that the dentino-enamel junctional complex should also include the inner aprismatic enamel and the mantle dentin. At early stages of enamel formation, fibroblast growth factor (FGF)-2 is stored in and released from the inner aprismatic enamel, possibly under the control of matrix metalloproteinase (MMP)-3. The concentration peak for MMP-2 and -9 observed in the mantle dentin coincided with a very low labeling for TIMP-1 and -2, favoring the cross-talk between mineralizing epithelial and connective structures, and as a consequence the translocation of enamel proteins toward odontoblasts and pulp cells, and vice versa, the translocation of dentin proteins toward secretory ameloblasts and cells of the enamel organ. Finally, in X-linked hypophosphatemic rickets, large interglobular spaces in the circumpulpal dentin were the major defect induced by the gene alteration, whereas the mantle dentin was constantly unaffected. Altogether, these data plead for the recognition of the dentino-enamel junctional complex as a specific entity bearing its own biological characteristics.
authors.affiliation: Laboratoire de Biologie et Physiopathologie Crânio-faciales, EA 2496, Université Paris V, rue Maurice Arnoux, 92120 Montrouge, France. mgoldod@aol.com
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: D
authors.initials: D
authors.lastname: Septier
authors.forename: K
authors.initials: K
authors.lastname: Bourd
authors.forename: R
authors.initials: R
authors.lastname: Hall
authors.forename: J C
authors.initials: JC
authors.lastname: Jeanny
authors.forename: L
authors.initials: L
authors.lastname: Jonet
authors.forename: S
authors.initials: S
authors.lastname: Colin
authors.forename: F
authors.initials: F
authors.lastname: Tager
authors.forename: C
authors.initials: C
authors.lastname: Chaussain-Miller
authors.forename: M
authors.initials: M
authors.lastname: Garabédian
authors.forename: A
authors.initials: A
authors.lastname: George
authors.forename: H
authors.initials: H
authors.lastname: Goldberg
authors.forename: S
authors.initials: S
authors.lastname: Menashi
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D003743:Dental Enamel / Q000196:embryology*; D003804:Dentin / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019812:Heparan Sulfate Proteoglycans; D016222:Fibroblast Growth Factor 2; D019278:Matrix Metalloproteinase 3; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9