Minocycline-ethylenediaminetetraacetate lock solution for the prevention of implantable port infections in children with cancer.
In this prospective cohort study, minocycline-ethylenediaminetetraacetate (M-EDTA) was used as a lock solution in indwelling ports inserted in 14 children with cancer. No port infections, thrombotic events, or other adverse events were observed, compared with 10 port infections that occurred in 48 control patients whose ports were flushed with heparin. M-EDTA is a promising lock solution in long-term catheters.
Chatzinikolaou
Ioannis
I
Division of Internal Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Zipf
Theodore F
TF
Hanna
Hend
H
Umphrey
Jan
J
Roberts
W Mark
WM
Sherertz
Robert
R
Hachem
Ray
R
Raad
Issam
I
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D002614:Chelating Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D009369:Neoplasms / Q000150:complications*; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D013927:Thrombosis / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D004492:Edetic Acid; D008911:Minocycline