title: 2,5-hexanedione-induced testicular injury.
abstract: Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.
authors.affiliation: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA. Kim_Boekelheide@Brown.edu
authors.forename: Kim
authors.initials: K
authors.lastname: Boekelheide
authors.forename: Shawna L
authors.initials: SL
authors.lastname: Fleming
authors.forename: Theresa
authors.initials: T
authors.lastname: Allio
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Embree-Ku
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Hall
authors.forename: Kamin J
authors.initials: KJ
authors.lastname: Johnson
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kwon
authors.forename: Sutchin R
authors.initials: SR
authors.lastname: Patel
authors.forename: Reza J
authors.initials: RJ
authors.lastname: Rasoulpour
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Schoenfeld
authors.forename: Stephanie
authors.initials: S
authors.lastname: Thompson
mesh_terms: D000818:Animals; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004195:Disease Models, Animal; D004785:Environmental Pollutants / Q000633:toxicity*; D006588:Hexanones / Q000633:toxicity*; D006801:Humans; D008297:Male; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D003432:Cross-Linking Reagents; D004785:Environmental Pollutants; D006588:Hexanones; C011269:2,5-hexanedione