Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells.
This study examines the effects of paroxetine and imipramine on intracellular concentrations of cyclic adenosine monophosphate (cAMP) in human peripheral blood mononuclear cells. It was found that imipramine and paroxetine had no effect on basal cAMP-levels. Stimulation with lipopolysaccharides and phytohaemagglutinin increased intracellular cAMP concentrations. However, pre-incubation with imipramine or paroxetine, did not influence this increase. These data do not support the hypothesis that cAMP may be related to the in vitro anti-inflammatory effects of antidepressants.
Kenis
Gunter
G
Department of Psychiatry and Neuropsychology, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands. g.kenis@np.unimaas.nl
Steinbusch
Harry
H
De Baets
Marc
M
Maes
Michael
M
D000928:Antidepressive Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D017374:Paroxetine / Q000494:pharmacology; D010835:Phytohemagglutinins
D000928:Antidepressive Agents; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D017374:Paroxetine; D000242:Cyclic AMP; D007099:Imipramine