title: Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice.
abstract: It is known that retinally degenerate C57BL/6J (rd/rd) mice have unattenuated circadian photosensitivity. However, the authors have previously found that CBA/J (rd/rd) mice that carry the same rd mutation have attenuated circadian photosensitivity compared to normal CBA/N (+/+) mice. In the present study, a quantitative trait locus (QTL) analysis using C57BL/6J (rd/rd) and CBA/J (rd/rd) mice was conducted in order to identify the genes affecting circadian photosensitivity of the rd mice. As a result, several putative QTLs onthree separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes. Identification of these genes may provide new insights into the understanding of regulation of circadian photoentrainment and sleep-wake disorders.
authors.affiliation: Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. takashiy@agr.nagoya-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yokota
authors.forename: Akira
authors.initials: A
authors.lastname: Ishikawa
authors.forename: Shinobu
authors.initials: S
authors.lastname: Yasuo
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Tohru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naritoshi
authors.initials: N
authors.lastname: Okabayashi
authors.forename: Takao
authors.initials: T
authors.lastname: Namikawa
authors.forename: Shizufumi
authors.initials: S
authors.lastname: Ebihara
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002940:Circadian Rhythm / Q000528:radiation effects*; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010787:Photosensitivity Disorders / Q000235:genetics* / Q000503:physiopathology; D040641:Quantitative Trait Loci; D012162:Retinal Degeneration / Q000235:genetics*