title: Synthesis of the C20-C26 building block of halichondrins via a regiospecific and stereoselective S(N)2' reaction.
abstract: [reaction: see text] A regiospecific and stereoselective S(N)2' reaction to convert the trisylate into the vinyl iodide is presented. The homoallylic alcohol is used to direct the delivery of LiCu(Me)(2).
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Chaoyu
authors.initials: C
authors.lastname: Xie
authors.forename: Pawel
authors.initials: P
authors.lastname: Nowak
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kishi
mesh_terms: D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004988:Ethers, Cyclic