title: Monoarthritis secondary to joint metastasis. Two case reports and literature review.
abstract: Synovial metastases from neoplasms are uncommon. We report two cases of knee monoarthritis due to joint metastasis. Joint fluid cytology established the diagnosis. In one patient, an epidermoid carcinoma of the ureter metastasized to the left knee. The other patient had chronic monoarthritis of the left knee unresponsive to conventional treatment and was found to have distal femoral metastases from a lung adenocarcinoma. Only 28 cases of synovial metastases from solid tumors have been reported in the literature. The knee is the most common target, the lung the most common site of the primary (12 cases), and adenocarcinoma the most common histological type (12 cases). Joint metastasis carries a poor prognosis with a mean survival of less than 5 months.
authors.affiliation: Department of Rheumatology, Bichat-Claude Bernard Teaching Hospital, 46, rue Henri Huchard, 75018 Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Younes
authors.forename: Gilles
authors.initials: G
authors.lastname: Hayem
authors.forename: Philippe
authors.initials: P
authors.lastname: Brissaud
authors.forename: Maggy
authors.initials: M
authors.lastname: Grossin
authors.forename: Marcel-Francis
authors.initials: MF
authors.lastname: Kahn
authors.forename: Olivier
authors.initials: O
authors.lastname: Meyer
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001168:Arthritis / Q000209:etiology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000473:pathology; D014516:Ureteral Neoplasms / Q000473:pathology* / Q000532:radiotherapy