title: The medical and surgical management of chronic anal fissure.
abstract: Major advances in our understanding of the mechanisms involved in chronic anal fissure have allowed the introduction of many new medical therapies for this condition. The literature about current treatment modalities licensed for anal fissure and those novel therapies still under evaluation has been reviewed. These new treatments are examined in the context of traditional surgical management of the disease and a future treatment algorithm suggested.
authors.affiliation: Department of Colorectal Surgery, Frimley Park Hospital, Portsmouth Road, Frimley, Camberley, Surrey, GU16 7UJ. garners@dialstart.net
authors.forename: J P
authors.initials: JP
authors.lastname: Garner
authors.forename: M
authors.initials: M
authors.lastname: McFall
authors.forename: D P
authors.initials: DP
authors.lastname: Edwards
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002908:Chronic Disease; D005401:Fissure in Ano / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007217:Indoramin / Q000627:therapeutic use; D009465:Neuromuscular Agents / Q000627:therapeutic use; D005996:Nitroglycerin / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D009465:Neuromuscular Agents; D014665:Vasodilator Agents; D007217:Indoramin; D019274:Botulinum Toxins, Type A; D005996:Nitroglycerin