Mortalin: present and prospective.
Mortalin, also known as mthsp70/PBP74/GRP75, resides in multiple subcellular sites including mitochondria, ER, plasma membrane, cytoplasmic vesicles and cytosol. It is differentially distributed in normal and cancerous cells; the latter, when reverted back to normal phenotype, also show change in mortalin staining pattern similar to normal cells. Depending on its different subcellular niche and binding partner therein, mortalin is expected to perform multiple functions relevant to cell survival, control of proliferation and stress response.
Kaul
Sunil C
SC
Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Taira
Kazunari
K
Pereira-Smith
Olivia M
OM
Wadhwa
Renu
R
D000818:Animals; D002477:Cells / Q000737:chemistry*; D003593:Cytoplasm / Q000737:chemistry; D004721:Endoplasmic Reticulum / Q000737:chemistry; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D008928:Mitochondria / Q000737:chemistry; D024101:Mitochondrial Proteins
D018840:HSP70 Heat-Shock Proteins; C492001:HSPA9 protein, human; D024101:Mitochondrial Proteins; C080352:mortalin