title: Treatment of out-of-hospital status epilepticus with diazepam rectal gel.
abstract: Intravenous access cannot always be promptly obtained when treating status epilepticus outside the hospital. We compared the efficacy and safety of diazepam rectal gel to IV lorazepam in our long-term care facility for adults with developmental disabilities. Diazepam rectal gel was given more quickly and reliably, reducing total seizure time, potential neuronal injury and other complications. A treatment protocol for treating status epilepticus with diazepam rectal gel is given.
authors.affiliation: Department of Neurology and the Regional Epilepsy Center, Fircrest and School of Pharmacy, University of Washington, Seattle 98155, USA. bfitz@u.washington.edu
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Fitzgerald
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Okos
authors.forename: John W
authors.initials: JW
authors.lastname: Miller
mesh_terms: D000285:Administration, Rectal; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000627:therapeutic use; D040561:Assisted Living Facilities / Q000706:statistics & numerical data; D003975:Diazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D019989:Persons with Intellectual Disabilities / Q000706:statistics & numerical data; D013226:Status Epilepticus / Q000188:drug therapy* / Q000451:nursing; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D008140:Lorazepam; D003975:Diazepam