[Dissemination of insertion sequences IS605, IS606 among clinical isolates of Helicobacter pylori in China].
OBJECTIVE
To study the distribution of IS605, IS606 among clinical isolates of Helicobacter pylori in China.


METHODS
A total of 104 H.pylori strains isolated from 5 different geographic regions in China were analyzed by PCR and dot-blot.


RESULTS
Forty-two strains out of the 104 isolates from 5 regions in China were found containing IS605 with 19 containing IS606. The frequency (66%) of IS605 positive strains from Yunnan province was higher than that from other areas. The different distribution of IS606 was neither associated with geographical regions nor with the presence of IS605 but IS606 were associated with the different clinical outcomes. However, the two reading frames ORFA and ORFB of IS605 were constantly coexisting.


CONCLUSIONS
In China, IS605 and IS606 of H. pylori were widely existing but the presence of IS605 in H. pylori might be associated with geographic origin.
Zhang
Maojun
M
Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Preventive, Beijing 102206, China.
Zhang
Jianzhong
J
He
Lihua
L
Guo
Haoyan
H
Yin
Yan
Y
Zhou
Zengfen
Z
D004251:DNA Transposable Elements; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction
D004251:DNA Transposable Elements