Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease.
OBJECTIVE
In this study we aimed to determine the levels of Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) in patients with inflammatory bowel disease (IBD) to investigate their contribution to tissue injury in inflammatory bowel disease.


METHODS
Forty-seven GSH-Px patients (35 with ulcerative colitis and 12 with Crohn's disease) and 30 healthy controls were included in the study. Their plasma and MDA levels were compared using nonparametric statistical methods.


RESULTS
Plasma GSH-Px levels of the patients group were significantly higher than the control group (p < 0.001). There was no significant difference between patients and controls in view of plasma levels of MDA.


CONCLUSIONS
High levels of GSH-Px, which is response against oxidative stress, indicates the increase of free radicals in IBD, while normal plasma MDA levels suggest the clearance of free radicals without leading to lipid peroxidation. Our result reveals that there is an existing antioxidant capacity despite oxidative stress in patients with IBD.
Tüzün
Ahmet
A
Department of Gastroenterology, Gülhane Medical Academy and Medical Faculty, 06018 Etlik, Ankara, Turkey. ahmettuzun@yahoo.com
Erdil
Ahmet
A
Inal
Volkan
V
Aydin
Ahmet
A
Bağci
Sait
S
Yeşilova
Zeki
Z
Sayal
Ahmet
A
Karaeren
Necmettin
N
Dağalp
Kemal
K
D000328:Adult; D003093:Colitis, Ulcerative / Q000097:blood* / Q000201:enzymology; D003424:Crohn Disease / Q000097:blood* / Q000201:enzymology; D003627:Data Interpretation, Statistical; D005260:Female; D005609:Free Radicals / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology
D005609:Free Radicals; D008315:Malondialdehyde; D005979:Glutathione Peroxidase