Origin and filiation of human plasmacytoid dendritic cells.
Human plasmacytoid dendritic cells represent a rare population of leukocytes which produce high amounts of type I interferon in response to certain viruses. Although those cells were first described in 1958, there are still unsolved issues related to their origin and function. Recently, a leukemic counterpart of plasmacytoid dendritic cells was identified. Molecular approaches using either normal or leukemic plasmacytoid dendritic cells provide some new insights into the controversial lymphoid origin of those cells. The need for specific markers is still a critical aspect for the identification of plasmacytoid dendritic cells, whatever stage of differentiation, in normal as well as in pathological conditions. Hopefully, novel markers will allow delineation of the relationships between dendritic cells at different stages of differentiation/maturation along the myeloid and lymphoid lineages.
Brière
Francine
F
Laboratory for Immunological Research, Schering-Plough, Dardilly, France. francine.briere@spcorp.com
Bendriss-Vermare
Nathalie
N
Delale
Thomas
T
Burg
Stéphanie
S
Corbet
Christophe
C
Rissoan
Marie Clotilde
MC
Chaperot
Laurence
L
Plumas
Joël
J
Jacob
Marie-Christine
MC
Trinchieri
Giorgio
G
Bates
Elizabeth E M
EE
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D010950:Plasma Cells; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D015703:Antigens, CD; D007370:Interferon Type I