title: Neurosecretory and non-neurosecretory parvocellular neurones of the hypothalamic paraventricular nucleus express distinct electrophysiological properties.
abstract: Parvocellular neurones of the hypothalamic paraventricular nucleus (PVN) comprise neurosecretory and non-neurosecretory subpopulations. We labelled neurosecretory neurones with intravenous injection of the retrograde tracer, fluoro-gold, and recorded from fluoro-gold-positive and negative PVN parvocellular neurones in hypothalamic slices. Non-neurosecretory parvocellular neurones generated a low-threshold spike (LTS) and robust T-type Ca2+ current, whereas neurosecretory neurones showed no LTS and a small T-current. LTS neurones were located in non-neurosecretory regions of the PVN, and non-LTS neurones were located in neurosecretory regions of the PVN. These findings indicate that neurosecretory and non-neurosecretory subtypes of parvocellular PVN neurones express distinct membrane electrical properties.
authors.affiliation: Neuroscience Program, Molecular and Cellular Biology Program, and Neurobiology Division of the Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118-5698, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Luther
authors.forename: S S
authors.initials: SS
authors.lastname: Daftary
authors.forename: C
authors.initials: C
authors.lastname: Boudaba
authors.forename: G C
authors.initials: GC
authors.lastname: Gould
authors.forename: K Cs
authors.initials: KC
authors.lastname: Halmos
authors.forename: J G
authors.initials: JG
authors.lastname: Tasker
mesh_terms: D000200:Action Potentials; D000818:Animals; D020747:Calcium Channels, T-Type / Q000502:physiology; D020644:Midline Thalamic Nuclei / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D051381:Rats
chemical_list: D020747:Calcium Channels, T-Type