Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease.
Endolymphatic hydrops is the pathologic feature associated with Meniere's disease. The development of endolymphatic hydrops appears to arise from multifactorial inheritance with alteration of endolymphatic homeostasis. Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity.
Paparella
Michael M
MM
Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA. papar001@tc.umn.edu
Djalilian
Hamid R
HR
D000818:Animals; D015551:Autoimmunity; D004710:Endolymph / Q000502:physiology; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000209:etiology; D004712:Endolymphatic Sac / Q000502:physiology; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D008575:Meniere Disease / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D009154:Mutation; D013701:Temporal Bone / Q000473:pathology; D014667:Vasopressins / Q000502:physiology; D014777:Virus Diseases / Q000150:complications
D014667:Vasopressins