Effect of roots aqueous extract of Delphinium denudatum on morphine-induced tolerance in mice.
The aqueous extract of Delphinium denudatum (Dd) roots showed a significant effect against morphine- (10 mg/kg) induced tolerance and dependence in mice. Oral administration of the extract (200-1600 mg/kg) showed a significant dose-dependent inhibition of naloxone- (1 mg/kg) induced withdrawal.
Zafar
Shadab
S
Department of Ilmul Advia (Pharmacology), Faculty of Medicine (Unani), Hamdard University, Hamdard Nagar, New Delhi 110062, India. shadabzafar@rediffmail.com
Ahmad
M Aftab
MA
Siddiqui
Tariq A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D031882:Delphinium / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000188:drug therapy; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D009020:Morphine