Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses.
Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis. We examined the inhibitory effects of this drug on the flare and wheal responses induced by histamine iontophoresis at 30, 60, and 90 min after oral administration in a double-blind, cross-over, and placebo-controlled study. Olopatadine hydrochloride significantly inhibited the histamine-induced flare and wheal responses as early as 60 min after oral administration when compared with placebo. Significant inihibitory effects of olopatadine hydrochloride on the itch responses were seen at 90 min after administration. Thus, olopatadine hydrochloride exhibited a very rapid and potent antihistamine effect on the histamine-induced skin responses.
Morita
Keisuke
K
Department of Dermatology, Graduate School of Medical Sciences, Fukuoka, Japan.
Koga
Tetsuya
T
Moroi
Yoichi
Y
Urabe
Kazunori
K
Furue
Masutaka
M
D000284:Administration, Oral; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006632:Histamine; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage*; D006801:Humans; D017336:Loratadine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011336:Probability; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology; D012016:Reference Values; D012882:Skin Tests; D016896:Treatment Outcome; D014581:Urticaria / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; D006632:Histamine