title: Graves-Basedow's disease in children and adolescents: total vs subtotal thyroidectomy.
abstract: "Graves' disease" is an autoimmune pathology and is the most important cause of hyperthyroidism in children and adolescents. The treatment for this disease is controversial; there are three different options: synthetic antithyroid drugs, ablation of the thyroid gland with I 131 or surgery. Our study reports the clinical and therapeutic aspects and long-term results of 27 patients (< = 18 years old) treated with total thyroidectomy or "near-total" thyroidectomy from 1975 to August 2001. Antithyroid drugs represent the preliminary treatment of choice. For a long time in the past therapy with radioactive iodine was not recommended; now it represents an efficiently therapy with low morbility. Surgical treatment is suitable when a young patient presents a considerable enlargement of the thyroid gland or when antithyroid medical treatment does not achieve a good control of the disease, or when rapid control of hyperthyroidism is necessary. The surgical treatment can be a total thyroidectomy or a "near-total" thyroidectomy. The first is the best choice for us, because it has a low risk of relapse and a major efficacy in the ophthalmopathy.
authors.affiliation: Cattedra di Chirurgia Pediatrica, Università di Pisa, Via Roma 67. spicla@interfree.it
authors.forename: C
authors.initials: C
authors.lastname: Spinelli
authors.forename: A
authors.initials: A
authors.lastname: Bertocchini
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: P
authors.initials: P
authors.lastname: Miccoli
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006111:Graves Disease / Q000601:surgery*; D006801:Humans; D008297:Male; D013965:Thyroidectomy / Q000379:methods*