title: UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.
abstract: [structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida, Japan. tsutomu.agatsuma@kyowa.co.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Akama
authors.forename: Shinji
authors.initials: S
authors.lastname: Nara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsumiya
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Nakai
authors.forename: Harumi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shizuo
authors.initials: S
authors.lastname: Otaki
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kanda
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D018360:Crystallography, X-Ray; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids; C409195:UCS 1025A; C470811:UCS1025B