title: [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid].
abstract: We estimated the effects of dietary administration of docosahexaenoic acid (DHA, 22:6n-3) on rat spatial cognition using young male Wistar rats. Chronic administration of DHA to rats increased the hippocampal levels of DHA. Six weeks after the start of the administration, the rats were for 5 weeks trained to acquire a reward at the end of each of 4 arms of an 8-arm radial maze. The retention test interposed with a delayed task (20-min interval after the first 2 free choices) was then given to each rat to determine spatial working memory retention. On completion of the test, the Fos expression in the hippocampus was examined immunohistochemically. DHA administration reduced the number of working memory errors after the 20-min interval in the retention test. The number of Fos-positive neurons in the CA1 hippocampus demonstrated a statistically significant negative correlation with the number of working memory errors, suggesting that the DHA-induced improvement in spatial cognition is associated with increased Fos expression in the CA1 hippocampus.
authors.affiliation: Department of Physiology, Shimane Medical University, Izumo 693-8501, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Fujii
authors.forename: Rika
authors.initials: R
authors.lastname: Hagiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Shido
mesh_terms: D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012153:Retention, Psychology / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects*; D013268:Stimulation, Chemical
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D004281:Docosahexaenoic Acids