Risk of death following pregnancy in rural Nepal.
OBJECTIVE
To investigate the length of time following pregnancy during which the risk of mortality was elevated among women in rural Nepal.


METHODS
An analysis was performed of prospective data on women participating in the control group of a large, population-based trial. Weekly visits were made for three years to 14805 women aged 14-45 years. Pregnancy and vital status were assessed. A total of 7325 pregnancies were followed. Mortality during and following pregnancy, expressed on a person-time basis, was compared to referent mortality unrelated to pregnancy (52 weeks after pregnancy) in the same cohort.


RESULTS
The relative risk (RR) of death during pregnancy but before the onset of labour was 0.93 (95% confidence interval (CI): 0.38-2.32). During the perinatal period, defined as lasting from the onset of labour until seven days after outcome, the RR of death was 37.02 (95% CI: 15.03-90.92). The RR for 2 to 6 weeks, 7 to 12 weeks, and 13 to 52 weeks after pregnancy were 4.82, 2.59 and 1.01 with 95% CI of 1.77-13.07, 0.81-8.26 and 0.40-2.53, respectively. The RR of death was 2.21 (95% CI. 1.03-4.71) during the conventional maternal mortality period (pregnancy until 6 weeks after outcome). It was 2.26 (95% CI: 1.05-4.90) when the period was extended to 12 weeks after pregnancy outcome.


CONCLUSIONS
The risk of mortality associated with pregnancy should be assessed over the first 12 weeks following outcome instead of over the first 6 weeks.
Pradhan
Elizabeth Kimbrough
EK
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205-2103, USA. kwest@jhsph.edu
West
Keith P
KP
Katz
Joanne
J
Christian
Parul
P
Khatry
Subarna K
SK
Leclerq
Steven C
SC
Dali
Sanu Maiya
SM
Shrestha
Sharada Ram
SR
D000328:Adult; D002423:Cause of Death; D035061:Control Groups; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D006801:Humans; D008428:Maternal Mortality; D009390:Nepal / Q000453:epidemiology; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000401:mortality*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012423:Rural Health / Q000706:statistics & numerical data*