Pathogenicity of embryo-adapted serotype 2 OH strain of infectious bursal disease virus in chickens and turkeys.
The pathogenicity of serotype 2 OH strain of infectious bursal disease virus (IBDV) to specific-pathogen-free (SPF) chicken embryos and 2-wk-old SPF chickens and turkey poults was investigated. The virus was pathogenic for chicken embryos after five passages as evidenced by pathologic changes in inoculated embryos. The embryo-adapted virus was not pathogenic for 2-wk-old SPF chickens and turkey poults as indicated by lack of clinical signs, gross or microscopic lesions in the bursa of Fabricius of inoculated birds. Bursa-to-body-weight ratios of the inoculated chickens and turkey poults were not significantly different from those of uninoculated controls. Virus-neutralizing antibodies to serotype 2 IBDV were detected in inoculated chickens and turkeys. Results of this study indicated that the embryo-adapted serotype 2 OH IBDV isolate that is pathogenic for chicken embryos is infectious but not pathogenic in chickens and turkeys.
Abdel-Alim
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GA
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA.
Saif
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YM
D000818:Animals; D018175:Birnaviridae Infections / Q000473:pathology / Q000662:veterinary*; D002060:Bursa of Fabricius / Q000473:pathology; D002642:Chick Embryo / Q000821:virology*; D002645:Chickens; D004625:Embryo, Nonmammalian / Q000821:virology*; D007243:Infectious bursal disease virus / Q000145:classification / Q000472:pathogenicity*; D008099:Liver / Q000196:embryology / Q000473:pathology; D009336:Necrosis; D011201:Poultry Diseases / Q000473:pathology / Q000821:virology*; D012703:Serotyping; D014422:Turkeys