Incidental diagnosis and tempestive therapy in a case of neonatal alloimmune thrombocytopenia due to anti-HPA-5b.
Neonatal alloimmune thrombocytopenia (NAIT) is usually attributable to HPA-1a antibodies. The authors report a case of incidentally diagnosed thrombocytopenia in a small for gestational age infant. A NAIT was suspected and she was successfully treated with intravenous IgG. The direct and indirect platelet suspension immunofluorescence test (PSIFT) in maternal blood suggested alloimmunization to HPA-5b. Empiric treatment with IgG could be useful in case of clear suspect even in absence of confirmed diagnosis.
Zuppa
Antonio Alberto
AA
Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
Cota
Francesco
F
De Luca
Daniele
D
Visintini
Federica
F
De Turris
Pier Luigi
PL
Tortorolo
Giuseppe
G
D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D005331:Fetomaternal Transfusion; D015200:Fluoroimmunoassay; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology*
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies