Circulating adhesion molecule levels in childhood asthma.
The present study aims at comparing the levels of circulating forms of E-selectin, ICAM-1 and VCAM-1 in 10 patients with acute asthma, 10 stable atopic asthmatics, 10 nonatopic stable asthmatics and 10 age-matched healthy children. sE-selectin levels of patients with acute asthma were found to be significantly higher than that of the other three groups. The insignificant rise in sICAM-1 levels was attributed to the usage of inhaler corticosteroids. Serum sE-selectin and sICAM-1 seem to be promising serological markers for monitoring disease activity in childhood asthma.
Doğu
Figen
F
Department of pediatric Immunology-Allergy, Ankara University, School of Medicine, Ankara, Turkey. esin.figen@veezy.com
Ikincioğullari
Aydan
A
Eğin
Yonca
Y
Babacan
Emel
E
D000280:Administration, Inhalation; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D019040:E-Selectin; D005938:Glucocorticoids; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1