title: Computer-aided detection of polyps in a colon phantom: effect of scan orientation, polyp size, collimation, and dose.
abstract: OBJECTIVE
  To determine the importance of polyp size, orientation to the scan plane, collimation, scanner type (single or multislice helical), and radiation dose on computed tomography (CT) colonography computer-aided detection.
  
  
  METHODS
  Eight tissue-equivalent simulated polyps were placed into the interior of an air-filled acrylic tube placed within a water-filled box. Their sizes, expressed by diameter and height in millimeters, were 10 x 10, 10 x 7, 10 x 5, 10 x 3, 7 x 7, 7 x 5, 7 x 3, and 5 x 5. Detection of the polyps was performed by applying our prototype automated polyp detector software to 48 CT colonography data sets of the phantom acquired with different CT scanner settings.
  
  
  RESULTS
  We detected at least six of the eight polyps in 47 of 48 experiments. The two most frequently undetected polyps (7 x 7 and 5 x 5) had extreme eccentricity (their height was twice the radius of the base) and were most commonly missed for 90 degrees tube orientation, 5-mm collimation, and high table speed. False-positive detections occurred in only 5 of 48 experiments.
  
  
  CONCLUSIONS
  Clinically significant 10-mm polyps can be detected with 100% sensitivity in all orientations, doses, collimations, and modes that we examined.
authors.affiliation: Institute for Medical Imaging and Image Analysis, Department of Electrical and Computer Engineering, George Washington University, Washington, DC, USA.
authors.forename: Shuo-Hung
authors.initials: SH
authors.lastname: Ling
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Summers
authors.forename: Murray H
authors.initials: MH
authors.lastname: Loew
authors.forename: Cynthia H
authors.initials: CH
authors.lastname: McCollough
authors.forename: C Daniel
authors.initials: CD
authors.lastname: Johnson
mesh_terms: D016477:Artifacts; D003111:Colonic Polyps / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*