Interlaminar connections in the neocortex.
This review summarizes the local circuit, interlaminar connections in adult mammalian neocortex. These were first demonstrated with anatomical techniques, which indicate some of the exquisite spatial precision present in the circuitry. Details, such as the class(es) of neurons targeted by some of these projections, have begun to be added in studies that combine paired/triple intracellular recordings with dye-filling of connected neurons. Clear patterns are emerging from these studies, with 'forward' projections from layer 4 to 3 and from 3 to 5 targeting both selected pyramidal cells and interneurons, while 'back' projections from layer 5 to 3 and from 3 to 4 target only interneurons. To place these data in a wider context, the major afferent inputs to and efferent outputs from each of the layers are discussed first.
Thomson
Alex M
AM
Department of Physiology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK. alext@rfc.ucl.ac.uk
Bannister
A Peter
AP
D000344:Afferent Pathways / Q000166:cytology; D000818:Animals; D002415:Cats; D003712:Dendrites; D004525:Efferent Pathways / Q000166:cytology; D005246:Feedback; D006801:Humans; D007395:Interneurons / Q000145:classification* / Q000166:cytology*; D019579:Neocortex / Q000033:anatomy & histology / Q000166:cytology*; D009415:Nerve Net / Q000033:anatomy & histology / Q000166:cytology*; D017966:Pyramidal Cells / Q000166:cytology*; D013788:Thalamus / Q000166:cytology*; D014785:Vision, Ocular / Q000502:physiology