title: Methinks it is like a folding curve.
abstract: Most often, the unfolded state of peptides and proteins has been modeled as a statistical random coil. Here, we suggest an alternative model based on the presence of a significant, temperature-dependent conformational bias in the unfolded population. Conformational bias is suggested by our calculations [Proc. Natl. Acad. Sci. USA 96 (1999) 14258-14263], and it is found in recent studies of both proteins and peptides. The imposition of even a modest bias would transform our assessment of the folding problem.
authors.affiliation: Jenkins Department of Biophysics, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA. raj@grserv.med.jhmi.edu
authors.forename: Rajgopal
authors.initials: R
authors.lastname: Srinivasan
authors.forename: George D
authors.initials: GD
authors.lastname: Rose
mesh_terms: D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding
chemical_list: D010455:Peptides