title: [Assessment of efficacy and safety of nebivolol in patients with stable effort angina].
abstract: OBJECTIVE
  To study efficacy and safety of nebivolol in patients with stable angina pectoris.
  
  
  METHODS
  Twenty patients with stable effort angina pectoris and positive exercise test without contraindications to beta-blockers, signs of NYHA class III-IV heart failure, and obstructive lung disease. After 5-7 days of control period all patients were given nebivolol (starting dose 5 mg/day) for 8 weeks. Graded exercise tests on treadmill and patient's diaries were used for assessment of treatment efficacy.
  
  
  RESULTS
  Treatment with nebivolol (5-10 mg o.d. ) was associated with significant slowing of heart rate, lowering of blood pressure, and increase of exercise duration until appearance of angina or 1 mm ST-segment depression. Nebivolol did not affect left ventricular ejection fraction, bronchial conductance, or results of biochemical tests (including lipid profile). Adverse reaction (dizziness which disappeared after lowering of a dose) was registered in 1 patient.
  
  
  CONCLUSIONS
  Nebivolol is an effective drug for the treatment of patients with stable angina.
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
authors.forename: V A
authors.initials: VA
authors.lastname: Sulimov
authors.forename: Yu V
authors.initials: YV
authors.lastname: Gavrilov
authors.forename: V V
authors.initials: VV
authors.lastname: Petriĭ
authors.forename: A S
authors.initials: AS
authors.lastname: Aksel'rod
authors.forename: V I
authors.initials: VI
authors.lastname: Buval'tsev
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D001578:Benzopyrans / Q000627:therapeutic use*; D004983:Ethanolamines / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D005082:Physical Exertion; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol