title: Sclerosing adenosis: mammographic and ultrasonographic findings with clinical and histopathological correlation.
abstract: OBJECTIVE
  To evaluate the mammographic and ultrasonographic findings of sclerosing adenosis, a relatively uncommon entity which may sometimes mimic carcinoma.
  
  
  METHODS
  A retrospective review of the records of 33,700 women, who have undergone mammographic examination at our institution between January 1985 and July 2001 revealed 43 histopathologically proven sclerosing adenosis. The history, physical examination, mammographic and ultrasonographic findings were analyzed in all patients. In 30 patients, the nonpalpable lesions were preoperatively localized by the needle-hookwire system under the guidance of mammography (n=22) or ultrasonography (US) (n=8). Radiological features were correlated with histopathological findings.
  
  
  RESULTS
  The age of the patients varied between 32 and 55 years (mean, 43.7 years). Only two patients had a family history of breast cancer. In six patients, the presenting complaint was mastalgia. A palpable mass was present in 13 cases. The mammographic findings were; microcalcifications in 24 (55.8%) (clustered in 22, diffuse in two), mass in five (11.6%), asymmetric focal density in three (6.9%), and focal architectural distortion in three (6.9%) patients. Four of the masses were irregularly contoured, while one was well-circumscribed. On US, focal acoustic shadowing without a mass configuration was noted in the three patients who showed asymmetrical focal density on mammography. In eight patients, who showed normal mammograms, a solid mass was detected on US. Two masses had discrete well-circumscribed oval or lobulated contours, while six showed microlobulation and irregularity. In one case, the irregularly contoured mass had marked posterior acoustic shadowing. Two of the three patients, who had focal architectural distortion on mammograms, had an irregularly contoured solid mass, while the third presented as focal acoustic shadowing without a mass configuration.
  
  
  CONCLUSIONS
  Sclerosing adenosis mostly presents as a nonpalpable lesion with different mammographic and sonographic appearances. The most common finding is microcalcifications on mammograms. Awareness of the possible imaging features will enable us to consider sclerosing adenosis in the differential diagnosis. The radiological features may sometimes mimic malignancy, so histopathologic examination is mandatory for definite diagnosis.
authors.affiliation: Department of Radiology, Faculty of Medicine, Ege University Hospital, Bornova, 35100 Izmir, Turkey. isilbilgen@hotmail.com
authors.forename: Işil
authors.initials: I
authors.lastname: Günhan-Bilgen
authors.forename: Ayşenur
authors.initials: A
authors.lastname: Memiş
authors.forename: Esin Emin
authors.initials: EE
authors.lastname: Ustün
authors.forename: Necmettin
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Erhan
mesh_terms: D000328:Adult; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D008327:Mammography; D008875:Middle Aged; D012189:Retrospective Studies; D012598:Sclerosis / Q000000981:diagnostic imaging; D016217:Ultrasonography, Mammary