[C-reactive protein as possible early prognostic marker of restenosis development in coronary artery stents].
OBJECTIVE
To study possible link between inflammatory response of the body to stent implantation and development of instent restenosis.


METHODS
C-reactive protein (CRP) was determined in 24 patients subjected to coronary stenting. Coronary angiography was repeated in 7.1-/+0.68 months after initial procedure.


RESULTS
At repeat angiography positive results of stenting persisted in 18 while restenosis developed in 6 patients. All patients had increased CRP levels on days 2-3 after stenting. Day 2 CRP levels were higher in patients with than without restenosis (28-/+4.22 mg/l and 14.17-/+2.14 mg/l, respectively, p<0.05). CRP levels tended to normalize by day 5.


CONCLUSIONS
Coronary artery stenting in patients with angina pectoris is associated with transitory elevation of CRP level. Day 2 CRP >or=24 mg/l with high degree of probability predicts restenosis in remote period.
Iarlykova
E I
EI
Kuchkina
N V
NV
Vorob'eva
E I
EI
Ioseliani
D G
DG
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D023921:Coronary Stenosis / Q000209:etiology / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D015607:Stents
D002097:C-Reactive Protein