[Revisited univariate delta check method for hematologic laboratories (II)--Causes of marked MCV change in identical patients with hematologic disorder].
We have identified causative factors contributing to marked mean corpuscular volume(MCV) change. We selected 38 patients who demonstrated changes in MCV of > or = 10 fl within less than 30 days. Of the 38 patients, 27 had received blood transfusions and 6 had undergone allogeneic bone marrow transplantation within the previous 2 months. No definitive cause was detected in 5 patients. In conclusion, blood transfusion and bone marrow transplantation can result in substantial MCV change in a short time and can represent confounding factors for the MCV delta check method.
Ohara
Tomoko
T
Department of Clinical Laboratory Medicine, Jichi Medical School, Kawachi-gun, Tochigi-pref. 329-0498.
Itoh
Kouichi
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques; D003951:Diagnostic Errors / Q000517:prevention & control*; D004909:Erythrocyte Indices; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000175:diagnosis*; D006403:Hematologic Tests / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013048:Specimen Handling; D013997:Time Factors