Hypermethylation pathways to colorectal cancer. Implications for prevention and detection.
Epigenetic changes play an important role in the development and progression of colorectal cancer. The best characterized of these changes is the promoter region methylation of CpG islands of genes that play key roles in this disease. These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches.
Herman
James G
JG
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans, Room 543, Baltimore, MD 21231, USA. hermanji@jhmi.edu
D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control; D018899:CpG Islands / Q000235:genetics*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000032:analysis*; D018450:Disease Progression; D006801:Humans
D004273:DNA, Neoplasm