title: Osteoclast-like giant cell tumor of the pancreas.
abstract: A rare case of osteoclast-like giant cell tumor of the pancreas is reported. A 45-year-old woman presented with upper abdominal pain and weight loss. Examination revealed a tumor in the tail of pancreas, and distal pancreatectomy with splenectomy was performed. Pathological findings showed the tumor was composed of two cell types: atypical mononuclear round cells and abundant osteoclast-like multinucleated giant cells with central nucleoli. Immunohistochemical study showed that the atypical cells were strongly reactive for vimentin and negative for CD68, while the giant cells were immunoreactive for CD68, but negative for vimentin. The tumor was diagnosed as osteoclast-like giant cell tumor of the pancreas. We report this case and review 31 cases previously described in the literature.
authors.affiliation: First Department of Surgery, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiwa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Kimiatsu
authors.initials: K
authors.lastname: Hasuo
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takanashi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
mesh_terms: D005260:Female; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography