title: [Staphylococci as uropathogens-frequency of isolation in hospitalized patients and sensitivity to antimicrobial agents].
abstract: For a period of 24 months (1997-1999) were isolated 266 clinically significant staphylococcal strains, S. aureus, 36 (13.5%) and 230 (86.5%) coagulase negative staphylococci (CNS) from urines of hospitalised patients (over 14 years) with UTI. The most frequently isolated strains from CNS was S. haemolyicus, 110 (47.8) strains, followed by S. saprophyticus 47 (20.4%) strains and S. epidermidis 18 (7.8%). The susceptibility of the isolates to 13 antimicrobial agents was determined by agar dilution method (NCCLS). From the isolated 36 strains S. aureus, 24 were sensitive and 12 were resistant to methicillin. From 230 CNS, 105 strains showed sensitivity and 125 strains resistance to methicillin. All staphylococci were sensitive to vancomycin and most of them (over 95%) to amikacin and rifampin. It was established a considerable difference between the sensitivity of methicillin-sensitive and methicillin-resistant staphylococci. The established resistance accompanied with high rate percentage methicillin resistance requires careful consideration to antimicrobial therapy of staphylococcal urinary tract infections (UTI).
authors.affiliation: Institut de recherches scientifiques de médecine urgente N.I. Pirogov division de clinique microbiologie et clinique d'urologie, 21, boulevard Totleben 1 606, Sofia, Bulgaria. janico@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Guirguitzova
authors.forename: D
authors.initials: D
authors.lastname: Chankova
authors.forename: B
authors.initials: B
authors.lastname: Zozikov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003428:Cross Infection; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents