title: [Evaluation of hepatic arterial infusion chemotherapy with levofolinate (l-LV) and 5-fluorouracil (5-FU) for multiple liver metastases from colorectal cancer].
abstract: We evaluated the effect of hepatic arterial infusion chemotherapy with levofolinate (l-LV) and 5-fluorouracil (5-FU) for multiple liver metastases from colorectal cancer. All patients received drugs on an outpatient basis every six weeks, followed by no medication for two weeks. In this regimen levofolinate (200 mg/m2) was administered for two hours and 5-fluorouracil (500 mg/m2) was administered for thirty minutes as a bolus. A complete response was obtained in five patients and a partial response in five patients; the overall response rate was 40%. All patients could receive this therapy on an outpatient basis because no patient had side effects of Grade 3 or over. It is suggested that our protocol may be useful for improvement of outcome.
authors.affiliation: Dept. of Surgery, Hyogo Prefectural Nisinomiya Hospital.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Soma
authors.forename: Tosio
authors.initials: T
authors.lastname: Kanai
authors.forename: Nariaki
authors.initials: N
authors.lastname: Fukuchi
authors.forename: Hikaru
authors.initials: H
authors.lastname: Izawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Isao
authors.initials: I
authors.lastname: Sakita
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D015179:Colorectal Neoplasms / Q000473:pathology*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
chemical_list: D002955:Leucovorin; D005472:Fluorouracil