title: Preoperative evaluation of primary hyperparathyroidism: role of diagnostic imaging.
abstract: This study analyses the diagnostic value of preoperative diagnostic imaging examinations in the identification and location of pathological parathyroid glands. We examined 77 patients with primary hyperparathyroidism using ultrasonography of the neck and Tc99m-MIBI scintigraphy for preoperative assessment purposes. All patients underwent surgical treatment. We compared the diagnostic imaging results with those furnished by histological examinations. TC99m-MIBI scintigraphy revealed the presence of a pathological parathyroid gland in 74/77 cases (96.1%) compared with 75/77 cases (97.4%) diagnosed by ultrasonography. The two examinations combined detected pathological glands in 100% of cases. The location of the pathological gland was correct in 57 cases (74.0%) at scintigraphy and in 56 cases (72.7%) at ultrasonography. In one case (1.3%) persistent hyperparathyroidism was demonstrated. There were no cases of relapse. In this study preoperative evaluation by ultrasonography and scintigraphy displayed great sensitivity in identifying and locating pathological parathyroid glands. Surgical neck exploration is still the gold standard in the correct location of pathological parathyroid glands measuring less than 5 mm.
authors.affiliation: Department of Surgical Science, La Sapienza University, Rome.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Panzironi
authors.forename: Laura
authors.initials: L
authors.lastname: Falvo
authors.forename: Marina
authors.initials: M
authors.lastname: De Vargas Macciucca
authors.forename: Antonio
authors.initials: A
authors.lastname: Catania
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sorrenti
authors.forename: Alessia
authors.initials: A
authors.lastname: Biancafarina
authors.forename: Flaminia
authors.initials: F
authors.lastname: De Cristofaro
authors.forename: Francesca
authors.initials: F
authors.lastname: Ricci
authors.forename: Enrico
authors.initials: E
authors.lastname: De Antoni
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D001706:Biopsy; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi