Sustaining pattern of phenformin hydrochloride using various polymers and waxes.
The present study was carried out to formulate matrix tablets of phenformin hydrochloride. Granules of phenformin HCl were prepared by using ethyl cellulose, eudragit RS 100, gum acacia, carnauba wax, stearyl alcohol, glyceryl monostearate and triethanol amine. Thus the granules were compressed and fourteen tablets formulations were prepared. All the physical parameters of granules and matrix tablets were studied including compatibility study. One commercial timed disintegration capsule was also included for study and comparison. The results of in vitro studies showed that sustained release matrix tablet might be prepared using carnauba wax, stearyl alcohol, triethanol amine and magnesium stearate.
Pandey
V P
VP
Department of Pharmacy, Annamalai University, Annamalainagar, T.N., India.
Kannappan
N
N
Manavalan
R
R
Subburaj
T
T
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004344:Drug Incompatibility; D005079:Excipients; D005233:Fatty Alcohols; D006170:Gum Arabic; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010629:Phenformin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011108:Polymers; D013501:Surface-Active Agents; D013607:Tablets; D014885:Waxes
D003692:Delayed-Action Preparations; D005079:Excipients; D005233:Fatty Alcohols; D007004:Hypoglycemic Agents; D011108:Polymers; D013501:Surface-Active Agents; D013607:Tablets; D014885:Waxes; C009316:stearyl alcohol; D006170:Gum Arabic; D010629:Phenformin