title: [Repeated intraperitoneal injection of low-dose CDDP for gastric cancer with ascites owing to peritonitis carcinomatosa].
abstract: We attempted treating 5 patients with ascites from peritonitis carcinomatosa of gastric carcinoma using TS-1 as systemic chemotherapy, and repeated intraperitoneal injection of low-dose CDDP for the carcinomatous ascites. TS-1 was administered in the usual manner and repeated intraperitoneal injection of CDDP (10 mg/body) dissolved in physiological saline 20-500 ml was given with an implantable reservoir. In 3 patients, the carcinomatous ascites disappeared, and in 2 other patients they decreased remarkably. As a result, the QOL and PS of all patients were improved. Serum concentration of CDDP suggested that weekly repeated intraperitoneally injected CDDP not only has an effect on peritonitis carcinomatosa, but also functions as a modulator for 5-FU.
authors.affiliation: Dept. of Internal Medicine, Hiroshima City Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Motoki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Isao
authors.initials: I
authors.lastname: Fujita
authors.forename: Minoru
authors.initials: M
authors.lastname: Matsubara
authors.forename: Yuhko
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawamoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Araki
authors.forename: Junichi
authors.initials: J
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Norinao
authors.initials: N
authors.lastname: Takakura
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001201:Ascites / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D010538:Peritonitis / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin