Analytical techniques for small molecule solid phase synthesis.
Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthesis either by monitoring the resin-bound species directly or by the analysis of small quantities of material cleaved from the support. This review outlines some of the principles of the various techniques for the analysis of intermediates and products obtained from solid-phase chemistry.
Scicinski
Jan J
JJ
ChemCodes Inc., 2300 Englert Drive, Durham, NC 27713, USA. jan_scicinski@chemcodes.com
Congreveb
Miles S
MS
Kay
Corinne
C
Ley
Steven V
SV
D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009930:Organic Chemicals / Q000032:analysis* / Q000138:chemical synthesis; D012117:Resins, Synthetic; D013055:Spectrophotometry, Infrared
D009930:Organic Chemicals; D012117:Resins, Synthetic