Effects of the dopamine antagonist PD 152255 on juvenile rats' responses to dorsal stimulation, the transport response, and related behaviors.
The authors gave 23- and 40-day-old rats doses of the dopamine D3 antagonist PD 152255 and tested them on transport response intensity, vertical cling catalepsy duration, and dorsal immobility duration. Administration of PD 152255 resulted in dose-dependent increases in transport response intensity in 40-day-old rats but was without effect in 23-day-old rats. Administration of PD 152255 caused increases in dorsal immobility durations in both 23- and 40-day-old subjects. The drug was without effect on vertical cling catalepsy. Results are discussed with respect to the role of D3 receptors in the transport response and the nature of D2-D3 receptor interactions.
Wilson
Christopher
C
Department of Psychology, Sam Houston State University, Huntsville, Texas 77341-2447, USA. psy_dcw@shsu.edu
Pulido
Marisa
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology*; D002375:Catalepsy / Q000209:etiology / Q000662:veterinary*; D008124:Locomotion / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology*; D050637:Receptors, Dopamine D3; D013315:Stress, Psychological
C111108:1,1'-(2-butene-1,4-diyl)bis(2-(4-(3-(1-piperidinyl)propoxy)phenyl)-1H-bnzimidazole); D001562:Benzimidazoles; C493595:Drd3 protein, rat; D010880:Piperidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3