title: Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius.
abstract: A new prenylated flavone, named artoindonesianin P (1), was isolated from the tree bark of Artocarpus lanceifolius, together with three known related compounds, artobiloxanthone (2), cycloartobiloxanthone (3) and artonol B (4). The structure of artoindonesianin P 1 was determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1-4 exhibited significant cytotoxicity against murine P388 leukemia cells.
authors.affiliation: Department of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132, Indonesia. euis@chem.itb.ac.id
authors.forename: Euis Holisotan
authors.initials: EH
authors.lastname: Hakim
authors.lastname: Asnizar
authors.lastname: Yurnawilis
authors.forename: Norio
authors.initials: N
authors.lastname: Aimi
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C473412:artoindonesianin P