title: [Development of intranasal lactocin (oxytocin) drops technology].
abstract: Pure oxytocin substance was obtained from posterior part of cattle pituitary gland by high pressure liquid chromatography. Biological activity of the substance--450-500 IU/mg. Chromatographically pure Oxytocin substance was used in developing two different compositions of Lactocin intranasal drops (40 IU/ml). Stability evaluation was performed for 2 year period. The technical documentation was prepared on the basis of the research results. Lactocin is active preparation helping lactation and is indicated for lactostasis treatment and its prophylaxis after delivery.
authors.affiliation: Kauno medicinos universiteto Vaistu technologijos ir farmacijos organizavimo katedra, Mickeviciaus 9, 3000 Kaunas.
authors.forename: Rimantas
authors.initials: R
authors.lastname: Klimas
authors.forename: Algirdas
authors.initials: A
authors.lastname: Baranauskas
authors.forename: Antanas
authors.initials: A
authors.lastname: Gendrolis
mesh_terms: D000328:Adult; D000818:Animals; D001942:Breast Feeding; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage* / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology / Q000592:standards; D019999:Pharmaceutical Solutions / Q000592:standards; D051381:Rats; D013678:Technology, Pharmaceutical; D013696:Temperature; D013997:Time Factors
chemical_list: D019999:Pharmaceutical Solutions; D010121:Oxytocin