title: Alternative venlafaxine kinetics in overdose.
abstract: The pharmacokinetics of venlafaxine in therapeutic doses is well established. It is metabolized by the cytochrome P450 enzymes including CYP2D6. The toxicokinetics in overdose is less well known.
  
  
  METHODS
  A 33-year-old Caucasian female who ingested 3.0 g venlafaxine, and 210 mg zolpidem. The patient remained symptomatic for the following 24 h. Plasma pharmacokinetic analysis demonstrated a prolonged elimination half-life of venlafaxine, estimated to be 15.3 h. We postulate that the patient was a slow metabolizer of substrates for CYP2D6, an enzyme known to exhibit polymorphism.
authors.affiliation: West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, UK. n.j.langford@bham.ac.uk
authors.forename: N J
authors.initials: NJ
authors.lastname: Langford
authors.forename: U
authors.initials: U
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Ruprah
authors.forename: R E
authors.initials: RE
authors.lastname: Ferner
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D019540:Area Under Curve; D003511:Cyclohexanols / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D003937:Diagnosis, Differential; D062787:Drug Overdose / Q000175:diagnosis; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000506:poisoning*; D011725:Pyridines / Q000008:administration & dosage / Q000506:poisoning*; D000069470:Venlafaxine Hydrochloride; D000077334:Zolpidem
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D006993:Hypnotics and Sedatives; D011725:Pyridines; D000069470:Venlafaxine Hydrochloride; D000077334:Zolpidem; D019389:Cytochrome P-450 CYP2D6