title: Therapeutic cancer vaccines based on molecularly defined human tumor antigens.
abstract: The results of numerous phases I and II clinical trials testing the safety and immunogenicity of various cancer vaccine formulations based on cytolytic T lymphocytes (CTLs)-defined tumor antigens have been reported recently. Specific T cell responses can be detected in only a fraction of immunized patients. A smaller but significant fraction of these patients have objective tumor responses. Efficient therapeutic vaccination should aim at boosting naturally occurring anti-tumor responses and at sustaining a large contingent of tumor antigen-specific and fully functional effector T cells at tumor sites.
authors.affiliation: Divison of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital, Avenue Pierre-Decker 4, 1005 Lausanne, Switzerland. pedro.romero@isrec.unil.ch
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero
authors.forename: Mikael
authors.initials: M
authors.lastname: Pittet
authors.forename: Valerie
authors.initials: V
authors.lastname: Dutoit
authors.forename: Alfred
authors.initials: A
authors.lastname: Zippelius
authors.forename: Danielle
authors.initials: D
authors.lastname: Liénard
authors.forename: Ferdy
authors.initials: F
authors.lastname: Lejeune
authors.forename: Philippe
authors.initials: P
authors.lastname: Guillaume
authors.forename: Donata
authors.initials: D
authors.lastname: Rimoldi
authors.forename: Danila
authors.initials: D
authors.lastname: Valmori
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Speiser
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Cerottini
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines