[Endoscopic local injection of anticancer drugs bound to carbon particles for treatment of advanced rectal cancer, when surgical treatment was contraindicated].
Generally, patients with advanced rectal cancer in whom surgical treatment is contraindicated receive radiation or chemotherapy. In such patients, we have administered local injection of methotrexate and mitomycin C bound to activated carbon particles. Four patients received intratumoral injection of the dosage formulation (total dose 100-400 mg of methotrexate or 8-32 mg of mitomycin C) under colonofiberscope. After the treatment, bleeding and pain were lessened in all 4 patients. In two patients, the tumor markedly decreased in size and there was no regrowth prior to death 12-14 months after the treatment. In another patient, bleeding and pain disappeared until the patient died of pulmonary and liver metastases. The fourth patient is alive without regrowth 5 months after treatment. Side effects were not severe.
Kin
Shuichi
S
Kyoto Prefectural University of Medicine.
Nakase
Yuen
Y
Fukuda
Kenichirou
K
Ito
Tadao
T
Shimomura
Katsumi
K
Takagi
Tsuyoshi
T
Toma
Atsushi
A
Fujiyama
Junshin
J
Okamoto
Kazuma
K
Sakakura
Chouhei
C
Otsuji
Eigo
E
Kitamura
Kazuya
K
Itoi
Hirosumi
H
Hagiwara
Akeo
A
Yamagishi
Hisakazu
H
D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002606:Charcoal / Q000008:administration & dosage*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D015552:Injections, Intralesional / Q000379:methods*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D016685:Mitomycin / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D002606:Charcoal; D016685:Mitomycin; D008727:Methotrexate