Animal models of cigarette smoke-induced COPD.
OBJECTIVE
To review the animal models of COPD, and to compare these data to those found in humans.


RESULTS
Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a species to study. Remarkably little information is available about the biochemical and molecular changes induced by cigarette smoke in animal models.


CONCLUSIONS
Great insights into the pathology of chronic obstructive lung disease have been made using various animal models.
Wright
Joanne L
JL
Department of Pathology, University of British Columbia, Vancouver, BC, Canada. jlwright@interchange.ubc.ca
Churg
Andrew
A
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001980:Bronchi / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D016207:Cytokines / Q000187:drug effects; D004285:Dogs; D004646:Emphysema / Q000209:etiology / Q000503:physiopathology; D006168:Guinea Pigs; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000503:physiopathology; D051379:Mice; D023421:Models, Animal; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D020545:Respiratory Mucosa / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects* / Q000503:physiopathology; D015431:Weight Loss / Q000187:drug effects
D016207:Cytokines