Experimental models of Schistosoma mansoni infection.
Experimental models of Schistosoma mansoni infections in mammals have contributed greatly to our understanding of the pathology and pathogenesis of infection. We consider here hepatic and extrahepatic disease in models of acute and chronic infection. Experimental schistosome infections have also contributed more broadly to our understanding of granulomatous inflammation and our understanding of Th1 versus Th2 related inflammation and particularly to Th2-mediated fibrosis of the liver.
Cheever
Allen W
AW
Biomedical Research Institute, MD 20852-1709, USA.
Lenzi
Jane A
JA
Lenzi
Henrique L
HL
Andrade
Zilton A
ZA
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006099:Granuloma / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D008103:Liver Cirrhosis / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000473:pathology; D013045:Species Specificity; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology