Enhanced external counterpulsation: mechanism of action.
The mechanisms accounting forthe salutary benefits of enhanced external counterpulsation (EECP) remain largely unknown. Emerging data now point to three possible hypotheses to explain its efficacy. These possible explanations include enhanced diastolic flow, changes in the neurohumoral milieu, and changes in ventricular function independent of changes in cardiac load. While each of these three hypotheses may help explain the mechanism behind EECP's effects, more clinical studies are required to refine these proposed explanations.
Feldman
Arthur M
AM
Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Arthur.Feldman@mail.tju.edu
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000254:growth & development; D015908:Counterpulsation / Q000379:methods*; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D016228:Endothelial Growth Factors; D009320:Atrial Natriuretic Factor