Synthesis of a new fluorescent probe specific for catechols.
[reaction: see text] The synthesis of a new fluorescent probe, specific for the catechol moiety, has been conducted by preparation of alpha,alpha-dibromomalonamides containing an appropriate fluorophore. N,N'-Bis-anthracen-9-ylmethyl-2,2-dibromomalonamide reacted with various catechols in the presence of cesium carbonate to generate highly fluorescent derivatives.
Stack
Douglas E
DE
Department of Chemistry, University of Nebraska at Omaha, 6001 Dodge Street, 68182-0109, USA. destack@unomaha.edu
Hill
Anastacia L
AL
Diffendaffer
Clark B
CB
Burns
Nicole M
NM
D000873:Anthracenes / Q000737:chemistry; D002396:Catechols / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry; D015394:Molecular Structure; D013194:Staining and Labeling; D013379:Substrate Specificity
D000873:Anthracenes; D002396:Catechols; D005456:Fluorescent Dyes; D008314:Malonates; C470822:N,N'-bis-anthracen-9-ylmethyl-2,2-dibromomalonamide