title: KL-6-producing invasive thymoma.
abstract: We report a patient with KL-6-producing invasive thymoma. A 58-year-old man was admitted complaining of dyspnea and fatigability. Computed tomography of the chest revealed interstitial pneumonia and an anterior mediastinal tumor. The tumor was surgically extirpated and diagnosed as invasive thymoma. Serum KL-6 levels later increased further and another tumor was found in the liver. That liver tumor was resected and histologically diagnosed as a metastasis of thymoma. Following resection, the serum KL-6 level decreased. Tumor cells of both primary and metastatic lesions exhibited positive reactivity to immunohistochemical staining for KL-6. A review of this case is presented.
authors.affiliation: First Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Kawata
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsukagoshi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Mashimo
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kasahara
authors.forename: Junko
authors.initials: J
authors.lastname: Iwasaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D013945:Thymoma / Q000378:metabolism* / Q000473:pathology; D013953:Thymus Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D009077:Mucins