Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.
We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL). This is an unusual association, and to date only seven cases have been reported. This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection. In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.
Osorio
S
S
Department of Hematology, Hospital de la Princesa, Madrid, Spain.
de la Cámara
R
R
Golbano
N
N
Marti
E
E
Fedele
C G
CG
Nieto
S
S
Manzanares
R
R
Fernández-Rañada
J M
JM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D001921:Brain / Q000821:virology; D000077404:Cidofovir; D003131:Combined Modality Therapy; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017809:Fatal Outcome; D018023:HIV Seronegativity; D006801:Humans; D016867:Immunocompromised Host; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000188:drug therapy / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects; D017211:Treatment Failure
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir