title: Impact of fusion avoidance on performance of the automatic threshold tracking feature in dual chamber pacemakers: a multicenter prospective randomized study.
abstract: The Autocapture algorithm enables automatic capture verification on a beat-by-beat basis by recognizing the evoked response signal following each pacemaker stimulus. The algorithm intends to increase patient safety while decreasing energy consumption. However, the occurrence of fusion beats, particularly during dual chamber pacing, may limit the energy saving effect of Autocapture. The aim of this multicenter, prospective, randomized study was to evaluate the impact of the Fusion Avoidance (FA) algorithm on the incidence of fusion beats. Thirty-eight patients (mean age 69 +/- 13 years) with intrinsic AV conduction who were implanted with an Affinity DR were studied. After programming a PV/AV delay of 120/190 ms, patients were randomized to FA On or Off. Each group was further randomized with respect to activation of the AutoIntrinsic Conduction Search (AICS) algorithm. The total number of beats, ventricular paced beats, fusion beats, backup pulses, and threshold searches were analyzed from 24-hour Holter recordings. The number of total beats was comparable in both FA groups. The number of total ventricular paced beats, fusion beats, backup pulses, and threshold searches were significantly reduced in the FA On group (% reduction: 68% P < 0.001, 75% P < 0.01, 95% P < 0.01, and 94% P < 0.05, respectively). The number of ventricular paced beats with full capture was significantly reduced when AICS was activated (P < 0.05). In conclusion, the FA algorithm substantially reduces the amount of ventricular paced beats, fusion beats, unnecessary backup pulses and threshold searches, and therefore, provides added benefits in energy saving obtained by Autocapture.
authors.affiliation: University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland. reto.candinas@dim.usz.ch
authors.forename: Reto
authors.initials: R
authors.lastname: Candinas
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Leal
authors.forename: Johannes
authors.initials: J
authors.lastname: Sperzel
authors.forename: Gerd
authors.initials: G
authors.lastname: Fröhlig
authors.forename: Christoph
authors.initials: C
authors.lastname: Scharf
authors.forename: Firat
authors.initials: F
authors.lastname: Duru
authors.forename: Hans
authors.initials: H
authors.lastname: Schüller
mesh_terms: D000368:Aged; D000465:Algorithms; D004562:Electrocardiography; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D011446:Prospective Studies