title: Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear.
abstract: Differential display analysis of differential mRNA expression in the rat inner ear under hypergravity identified two down- and four up-regulated genes. The up-regulation of microtubule associated protein 1A (MAP1A) in one of these was confirmed by real-time polymerase chain reaction. Since MAP1A is believed to work as a cell stabilizer connecting the actin with microtubule, this is possibly a response to strengthen this stabilizer under hypergravity. The MAP1A gene is the first found to be affected by gravity change in the inner ear.
authors.affiliation: Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takumi
authors.forename: Naoya
authors.initials: N
authors.lastname: Iijima
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Suzuki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Oguchi
authors.forename: Nagisa
authors.initials: N
authors.lastname: Ando
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Usami
mesh_terms: D000818:Animals; D001483:Base Sequence; D007758:Ear, Inner / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D018471:Hypergravity; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation / Q000502:physiology*
chemical_list: C093429:MAP1A protein, human; C490546:Map1a protein, rat; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger