title: [Assessment of safety and antihypertensive efficacy of a cardioselective beta-blocker nebivolol in patients with hypertension and concomitant chronic obstructive bronchitis].
abstract: Safety, tolerability and antihypertensive efficacy of a cardioselective beta-blocker nebivolol was studied in 30 patients with mild and moderate hypertension and concomitant stage I chronic obstructive bronchitis. Nebivolol (5 mg/day) was given for 1 month; in 5 patients complementary hydrochlorothiazide (12.5 mg/day) was required for sufficient antihypertensive effect. Nebivolol was well tolerated (only 1 patient complained of head ache), did not cause worsening of bronchitis and spirometric parameters, exerted no cardiodepressive action, and did not induce apparent disturbances of metabolism.
authors.forename: S S
authors.initials: SS
authors.lastname: Iakushin
authors.forename: V G
authors.initials: VG
authors.lastname: Okorokov
authors.forename: R A
authors.initials: RA
authors.lastname: Liferov
authors.forename: V A
authors.initials: VA
authors.lastname: Fomina
authors.forename: G O
authors.initials: GO
authors.lastname: Ivanova
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D001578:Benzopyrans / Q000009:adverse effects / Q000627:therapeutic use*; D029481:Bronchitis, Chronic / Q000150:complications*; D004983:Ethanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol
chemical_list: D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol