The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese.
Sulfotransferase (SULT) enzymes play an important role in the detoxification, metabolism and bioactivation of numerous xenobiotics, many dietary and environmental mutagens, drugs, neurotransmitters and hormones. The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in the level of enzyme activities as well as variations of biochemical and physical properties. We developed a PCR-RFLP method to analyze the frequencies of SULT1A1 and SULT1A2 alleles among cancerous patients and normal controls in Taiwan. The results showed that SULT1A1*1 and SULT1A2*1 were in positive linkage disequilibrium. Neither SULT1A1*3 nor SULT1A2*3 were found in this study. The frequencies of SULT1A1*2 and SULT1A2*2 for hepatic, colon, lung, oral, gastric, renal and cervical cancerous patients were 3.95, 5.56, 4.92, 3.84, 2.70, 7.41 and 4.50%, respectively. No statistical significance was found for these cancer patients after comparison with normal controls (4.0%) for the allelic frequencies of SULT1A1*2 and SULT1A2*2.
Peng
Ching-Tien
CT
Department of Molecular Medicine and Pediatrics, China Medical College Hospital, Taichung, Taiwan, ROC.
Chen
Jui-Chang
JC
Yeh
Kun-Tu
KT
Wang
Yu-Feng
YF
Hou
Ming-Feng
MF
Lee
Tai-Ping
TP
Shih
Mu-Chih
MC
Chang
Jan-Yi
JY
Chang
Jan-Gowth
JG
D015239:Arylsulfotransferase; D044466:Asian People / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D015810:Linkage Disequilibrium; D008175:Lung Neoplasms / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics; D009369:Neoplasms / Q000145:classification / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D013274:Stomach Neoplasms / Q000235:genetics; D015238:Sulfotransferases / Q000235:genetics*; D013624:Taiwan; D002583:Uterine Cervical Neoplasms / Q000235:genetics
D007527:Isoenzymes; D015238:Sulfotransferases; D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human; C513290:SULT1A2 protein, human