The pathogenesis of atopic eczema.
Atopic eczema is associated with a genetic predisposition to dysregulation of the immune system. T lymphocytes differentiate towards the Th2 type with promotion of immunoglobulin E antibodies. Allergic responses to environmental allergens develop and microbes, including staphylococci and pityrosporum yeasts, may contribute to the inflammatory process.
Friedmann
Peter S
PS
Dermatopharmacology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD.
D000485:Allergens / Q000276:immunology; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007378:Interleukins / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000382:microbiology; D012882:Skin Tests / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D007378:Interleukins; D007073:Immunoglobulin E