title: Prospective immunogenicity study of multiple intradermal injections of rabies vaccine in an effort to obtain an early immune response without the use of immunoglobulin.
abstract: The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8-site and double-dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.
authors.affiliation: World Health Organization Collaborating Center for Research in Rabies, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
authors.forename: Pakamatz
authors.initials: P
authors.lastname: Khawplod
authors.forename: Henry
authors.initials: H
authors.lastname: Wilde
authors.forename: Saovaluk
authors.initials: S
authors.lastname: Tepsumethanon
authors.forename: Sukunya
authors.initials: S
authors.lastname: Limusanno
authors.forename: Tanpetch
authors.initials: T
authors.lastname: Tantawichien
authors.forename: Pranee
authors.initials: P
authors.lastname: Chomchey
authors.forename: Ampai Bungjongkasaena Na
authors.initials: AB
authors.lastname: Ayuthaya
authors.forename: Yongyuth
authors.initials: Y
authors.lastname: Wangroonsarb
mesh_terms: D000328:Adult; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity; D007271:Injections, Intradermal; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000906:Antibodies; D011819:Rabies Vaccines