title: A case of lung cancer with hypercalcemia which was incidentally complicated with primary hyperparathyroidism due to parathyroid adenoma.
abstract: In lung cancer patients, hypercalcemia is a fairly common metabolic problem associated with malignancy. However, the occurrence of hypercalcemia in lung cancer patients means an ominous prognostic sign. As hypercalcemia often causes early death, quick diagnosis and treatment for hypercalcemia are required. A 69-year-old woman was admitted to our hospital with anorexia caused by hypercalcemia. On admission, serum level of PTH was elevated and PTHrP was normal. From the results of CT findings and transbronchial lung biopsy, the cause of the hypercalcemia was determined as lung cancer incidentally complicated with primary hyperparathyroidism. First, serum calcium level was returned to normal through hydration with saline and bisphosphonates. Next, left hemithyroidectomy for primary hyperparathyroidism was performed. Histologically, the tumor was diagnosed as parathyroid adenoma. Fifteen days later, left lower lobectomy for primary lung cancer was performed under a video-assisted thoracoscopic approach. Histologically, the tumor was diagnosed as a moderately differentiated adenocarcinoma. Four years and three months after the operation, the patient is alive and well with no sign of recurrence. When a lung cancer patient is complicated with hypercalcemia, we need to consider that primary hyperparathyroidism is a possible cause of the hypercalcemia.
authors.affiliation: Department of Surgery, Hakodate Central General Hospital.
authors.forename: Joe
authors.initials: J
authors.lastname: Matsumoto
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Kojima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shimizu
authors.forename: Shuji
authors.initials: S
authors.lastname: Kitashiro
authors.forename: Kazuya
authors.initials: K
authors.lastname: Konishi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Matsumura
authors.forename: You
authors.initials: Y
authors.lastname: Kawarada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiki
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery; D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D006961:Hyperparathyroidism / Q000150:complications* / Q000601:surgery; D008175:Lung Neoplasms / Q000150:complications* / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000601:surgery