Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis.
Acetylpyridine benzoyl hydrazone (APBH) 1 and its copper complex [[(APBH)CuCl](2)].(EtOH) 2 were structurally characterized by elemental analysis, magnetic measurements, spectroscopy, electrochemistry and single crystal X-ray diffraction studies. The ligand assumes Z-isomeric form and planar geometry in solid state, coordinating through pyridyl nitrogen, azomethine nitrogen and the carbonyl oxygen of the benzoyl group. The copper complex is dimeric and has a distorted octahedral geometry in which the two copper atoms are bridged by two chloride atoms. Antimycobacterial screening of ligand and its copper compound against Mycobacterium smegmatis shows clear enhancement in the antitubercular activity upon copper complexation.
Patole
Jayendra
J
Department of Chemistry, University of Pune, India.
Sandbhor
Uday
U
Padhye
Subhash
S
Deobagkar
Dileep N
DN
Anson
Christopher E
CE
Powell
Annie
A
D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D019281:Dimerization; D004563:Electrochemistry; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis; D013237:Stereoisomerism
D000995:Antitubercular Agents; D006834:Hydrazines; D008024:Ligands; D011725:Pyridines; C474661:acetylpyridine benzoyl hydrazine; D003300:Copper