title: Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model.
abstract: Studies in the SIVmac macaque model have demonstrated that the extent of virus-specific CD4+ and CD8+ T-cell responses induced by vaccination prior to virus-challenge exposure correlate with viremia containment following establishment of infection. These findings led to the hypothesis that active immunization with vaccines able to induce virus-specific T-cell responses following the establishment of infection could also ameliorate the virological outcome. Here, we will review the relative effect of ART and vaccination during primary SIVmac infection of macaques.
authors.affiliation: National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, MD 20892-5055, USA. franchig@mail.nih.gov
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Franchini
authors.forename: Janos
authors.initials: J
authors.lastname: Nacsa
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Hel
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Tryniszewska
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy*; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents