Ultrasound guided, pre-radiation oxygen measurements using polarographic oxygen needle electrodes in spontaneous canine soft tissue sarcomas.
BACKGROUND
Poor tumour oxygenation is associated with radiation resistance. The recording of pre-treatment oxygenation status has been shown to be of prognostic relevance.


METHODS
Eleven dogs with spontaneously arising soft tissue sarcomas were included in this study. Oxygen partial pressure measurements (pO2) were performed with the Eppendorf method.


RESULTS
The mean of median pO2 was 9.6 mmHg (range: 0.1-30 mmHg). Four of the nine dogs included in the statistical analysis showed a median pO2 < or = 2.5 mmHg. The natural logarithm of the hypoxic subvolume correlated with the hypoxic fraction < or = 2.5 mmHg (p = 0.0712) and < or 5 mmHg (p = 0.0988). Mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) correlated significantly to several oxygen parameters.


CONCLUSIONS
Hypoxia exists in spontaneous canine soft tissue sarcomas and the dog can be used as a reliable model for repeated oxygenation measurements. Ultrasonography assures reliability of needle placement.
Achermann
Roger
R
Section of Diagnostic Imaging and Radiation Oncology, Veterinary Hospital, University of Zurich, Zurich, Switzerland.
Ohlerth
Stefanie
S
Fidel
Janean
J
Gardelle
Olivier
O
Gassmann
Max
M
Roos
Malgorzata
M
Saunders
H Mark
HM
Scheid
Annette
A
Wergin
Melanie
M
Kaser-Hotz
Barbara
B
D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism* / Q000532:radiotherapy; D004285:Dogs; D017736:Ion-Selective Electrodes; D009367:Neoplasm Staging / Q000662:veterinary; D010100:Oxygen / Q000378:metabolism*; D011048:Polarography / Q000662:veterinary; D011379:Prognosis; D011878:Radiotherapy / Q000662:veterinary; D012509:Sarcoma / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D014463:Ultrasonography / Q000662:veterinary
D010100:Oxygen