Hypertension and related factors in the etiology of Alzheimer's disease.
The prevalence of hypertension is estimated to approach 50% in individuals above age 70. The consequences of hypertension include cerebrovascular disease, coronary heart disease, and general atherosclerosis. Several recent studies suggest that there may be an association also between hypertension and Alzheimer's disease (AD). This review will examine the evidence for this association and possible pathways between hypertension, Alzheimer encephalopathy, and clinical dementia.
Skoog
Ingmar
I
Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, Sweden. Ingmar.Skoog@neuro.gu.se
Gustafson
Deborah
D
D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D015995:Prevalence; D020521:Stroke / Q000209:etiology
D000959:Antihypertensive Agents