Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis.
It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.
Lépine
Sandrine
S
Biomembranes et Messagers Cellulaires, CNRS -UMR 8619, Université Paris XI, France.
Lakatos
Boris
B
Maziere
Pierre
P
Courageot
Marie-Pierre
MP
Sulpice
Jean-Claude
JC
Giraud
Françoise
F
D000818:Animals; D002478:Cells, Cultured; D002518:Ceramides / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013110:Sphingosine / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*
D002518:Ceramides; D003907:Dexamethasone; D013108:Sphingomyelin Phosphodiesterase; D013110:Sphingosine