Bacterial CpG-DNA licenses TLR9.
The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported. This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed.
Bauer
S
S
Institute for Medical Microbiology, Hygiene and Immunology, Trogerstrasse 9, 81675 Munich, Germany. stefan.bauer@lrz.tum.de
Wagner
H
H
D000818:Animals; D004269:DNA, Bacterial / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D029721:Drosophila Proteins; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins / Q000276:immunology; D009838:Oligodeoxyribonucleotides / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051194:Toll-Like Receptor 1; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors
C408982:CPG-oligonucleotide; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D009838:Oligodeoxyribonucleotides; D011956:Receptors, Cell Surface; C495371:TLR9 protein, human; D051194:Toll-Like Receptor 1; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors