HLA-DQ8 as an Ir gene in coeliac disease.
DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease
Lundin
K E A
KE
Department of Medicine and Institute of Immunology, Rikshospitalet, N-0027 Oslo, Norway. knut.lundin@rikshospitalet.no
D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D005903:Gliadin / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small
D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen; D005903:Gliadin