title: Expression of nuclear retinoic acid receptor in peripheral blood mononuclear cells (PBMC) of healthy subjects.
abstract: In vertebrates, both nuclear all-trans and 9-cis retinoic acid receptors (RAR and RXR) belonging to the steroid/thyroid/retinoid nuclear receptor superfamily play a crucial role in the vitamin A action. Qualitative analysis of all known RAR or RXR subtypes in both pooled and non-pooled peripheral blood mononuclear cells (PBMC) from healthy human subjects has been performed by reverse transcription and polymerase chain reaction (RT-PCR). Our data, based on qualitative RT-PCR analysis has shown that human PBMC are capable to express RAR alpha, RAR gamma, RXR alpha, and RXR beta.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Szabova
authors.forename: D
authors.initials: D
authors.lastname: Macejova
authors.forename: M
authors.initials: M
authors.lastname: Dvorcakova
authors.forename: S
authors.initials: S
authors.lastname: Mostbock
authors.forename: S
authors.initials: S
authors.lastname: Blazickova
authors.forename: S
authors.initials: S
authors.lastname: Zorad
authors.forename: S
authors.initials: S
authors.lastname: Walrand
authors.forename: N
authors.initials: N
authors.lastname: Cardinault
authors.forename: M P
authors.initials: MP
authors.lastname: Vasson
authors.forename: E
authors.initials: E
authors.lastname: Rock
authors.forename: J
authors.initials: J
authors.lastname: Brtko
mesh_terms: D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid