title: Effect of pediatric living-donor liver transplantation on splenomegaly.
abstract: BACKGROUND
  The effect of pediatric partial liver transplantation on hypersplenism has not yet been clarified.
  
  
  METHODS
  Fifty-five consecutive pediatric patients who underwent living-donor liver transplantation were analyzed. The volume of the spleen was measured by computed tomography, and the spleen volume-to-standard spleen volume ratio (R) was calculated in each patient. The platelet counts were examined preoperatively and at 1, 6, 12, 18, 24, 36, and 48 months after the operation. The rate of the decline in this ratio during 1 year was calculated, and correlations with clinical factors were examined.
  
  
  RESULTS
  The ratio decreased gradually after the operation in all of the patients except for three with an eventful postoperative course. The rate of the reduction in R within 1 year after the operation was well correlated with preoperative R (R(O); P<0.0001), which led to an equation for R at n months after the operation: R(n) =(0.31-0.21R(O) )Ln(3.3n+1)+R(O). The platelet counts increased rapidly in the patients with the uneventful postoperative course.
  
  
  CONCLUSIONS
  The normalization of spleen size can be expected with an uneventful living-donor liver transplantation. The spleen volume decreased more rapidly in patients with a larger spleen.
authors.affiliation: Liver Transplantation Team, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Egami
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Koichi
authors.initials: K
authors.lastname: Mizuta
authors.forename: Junichi
authors.initials: J
authors.lastname: Kaneko
authors.forename: Hideo
authors.initials: H
authors.lastname: Kawarasaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D007223:Infant; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D010976:Platelet Count; D013154:Spleen / Q000000981:diagnostic imaging; D013163:Splenomegaly / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed