Metalloproteinase in myocardial adaptation and maladaptation.
Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metalloproteinases, membrane type matrix metalloproteinases, and disintegrin metalloproteinase play a significant role in these processes. The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy.
Tyagi
Suresh C
SC
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Hoit
Brian D
BD
D000818:Animals; D006333:Heart Failure / Q000201:enzymology; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D020257:Ventricular Remodeling / Q000502:physiology
D008666:Metalloendopeptidases