Beyond collagen: injectable therapies for the treatment of female stress urinary incontinence in the new millennium.
Previous experience with GAX-collagen has shown that the endoscopic correction of female SUI is both possible and effective. It is clear, however, that durability remains a primary concern when implementing this approach to treatment. The availability of recently developed and newly emerging materials, carefully designed using the tenets and techniques of biotechnology and materials science, may provide solutions to some of the difficulties beleaguering this treatment option. Results with currently available injectables are summarized in Table 1. Careful review and critical analysis of new bulking agents will soon reveal which materials approach the therapeutic ideal. It is likely that the ultimate choice of a particular substance, synthetic or biologic, may best be determined by the clinical circumstances involving the individual patient.
Kershen
Richard T
RT
Scott Department of Urology, Baylor College of Medicine, 6562 Fannin, Suite 2100, Houston, TX 77030, USA. Rkershen@www.urol.bcm.tmc.edu
Dmochowski
Roger R
RR
Appell
Rodney A
RA
D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000627:therapeutic use*; D003094:Collagen / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections / Q000639:trends*; D014550:Urinary Incontinence, Stress / Q000188:drug therapy*
D001672:Biocompatible Materials; D003094:Collagen