title: Efficacy of stratum corneum lipid supplementation on human skin.
abstract: Recent studies suggest that supplementing intercellular lipids of the stratum corneum in ageing populations or in people with dry skin can stimulate the functioning of the skin. This work lends support to the reinforcement capacity of two different stratum corneum lipid mixtures (synthetic stratum corneum lipid mixtures, SSCL, and internal wool lipid extracts, IWL) formulated as liposomes on healthy skin of two differently aged groups of individuals. Protection of healthy skin against detergent-induced dermatitis was evaluated. Transepidermal water loss and capacitance were used to evaluate the effect of these formulations in in vivo long-term studies. Increase in water-holding capacity is obtained only when the formulations applied are structured as liposomes. This is slightly more pronounced for aged skin. Subsequent SLS exposure reflected the protection of healthy human skin against detergent-induced dermatitis. Slightly better results were obtained with IWL containing a mixture of natural ceramides than with SSCL with only one ceramide present in the formulation. All these results support the beneficial effects of skin lipid supplementation given their resemblance to the lipids in the stratum corneum both in composition and in the structuring of the formulation.
authors.affiliation: Instituto de Investigaciones Químicas y Ambientales de Barcelona (IIQAB), CSIC, Barcelona, Spain. lcnesl@cid.csic.es
authors.forename: L
authors.initials: L
authors.lastname: Coderch
authors.forename: M
authors.initials: M
authors.lastname: De Pera
authors.forename: J
authors.initials: J
authors.lastname: Fonollosa
authors.forename: A
authors.initials: A
authors.lastname: De La Maza
authors.forename: J
authors.initials: J
authors.lastname: Parra
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D046508:Culture Techniques; D004817:Epidermis / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012869:Skin Absorption / Q000187:drug effects; D015595:Skin Aging / Q000502:physiology*; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D008055:Lipids; D008081:Liposomes