Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection.
We report a patient with primary amenorrhea accompanied by adrenal adenoma. A 21-year-old woman was admitted to our hospital because of primary amenorrhea and hyperprogesteronemia without virilization. Venous sampling showed progesterone overproduction at the left adrenal gland. Computed tomography revealed a 7 cm mass in left adrenal gland. Serum pregnenorone, 17-hydroxypregnenorone, dehydroepiandrosterone, 17-hydroxyprogesterone, deoxycorticosterone, and 11-deoxycortisol were elevated. The diagnosis of steroid hormone producing tumor was made. Following tumor resection, serum progesterone normalized 4 days later, and menarche occurred 51 days after operation. The present case indicated that adrenal functioning tumor should not be overlooked in patients with primary amenorrhea.
Takahashi
Yoshimi
Y
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
Ninomiya
Jun
J
Horiguchi
Jun
J
Shimizu
Hiroyuki
H
Sato
Minoru
M
Koibuchi
Yukio
Y
Yoshida
Takashi
T
Yoshida
Miho
M
Takata
Daisuke
D
Odawara
Hiroki
H
Yokoe
Takao
T
Iino
Yuichi
Y
Morishita
Yasuo
Y
Mori
Masatomo
M
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000601:surgery; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D008572:Menarche