title: Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells.
abstract: The cells of most Old World monkey species exhibit early, postentry restrictions on infection by human immunodeficiency virus type 1 (HIV-1) but not by simian immunodeficiency virus of macaques (SIV(mac)). Conversely, SIV(mac), but not HIV-1, infection is blocked in most New World monkey cells. By using chimeric HIV-1/SIV(mac) viruses capable of a single round of infection, we demonstrated that a major viral determinant of this restriction is the capsid (CA) protein. The efficiency of early events following HIV-1 and SIV(mac) entry is apparently determined by the interaction of the incoming viral CA and species-specific host factors.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Owens
authors.forename: Peter C
authors.initials: PC
authors.lastname: Yang
authors.forename: Heinrich
authors.initials: H
authors.lastname: Göttlinger
authors.forename: Joseph
authors.initials: J
authors.lastname: Sodroski
mesh_terms: D000818:Animals; D002213:Capsid / Q000502:physiology*; D002460:Cell Line; D002678:Chimera; D015497:HIV-1 / Q000502:physiology*; D000882:Haplorhini / Q000821:virology*; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication