title: [Effect of MPA and MPA + TU on the rat spermatogenesis and sexual hormones].
abstract: OBJECTIVE
  To investigate the effect of administration of MPA with/without TU on serum sexual hormones and spermatogenesis of male rats.
  
  
  METHODS
  Twenty rats had been classified into four groups. Each group received injection of saline(group A) or MPA(37.5 or 75 mg/kg) (group B or group C, respectively) or MPA (75 mg/kg) + TU (25 mg/kg) (group D) every month during three months. Data from serum sexual hormones (FSH, LH, T), sperm counting and motility had been collected and analysed.
  
  
  RESULTS
  Spermatogenesis of rats undergoing administration of MPA with or without TU had been suppressed. Serum FSH and LH of group B, C, D declined, and so did serum T of group D. Testis of rats of group D atrophied and sperm counting of group D decreased remarkably compared with group B and C. But there was no statistics difference of the sexual hormone level among group B, C and D.
  
  
  CONCLUSIONS
  Administration of MPA alone could suppress the levels of FSH and LH and block the spermatogenesis of male rats. MPA combined with TU could offer stronger suppression on spermatogenesis. Mechanism of the suppression on spermatogenesis of MPA + TU is not only limited in the feed-back of gonadotropin, but there maybe exist a direct suppression on testis.
authors.affiliation: Research Center of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Jia
authors.forename: Yu-Gui
authors.initials: YG
authors.lastname: Cui
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Wang
authors.forename: Jian-Sun
authors.initials: JS
authors.lastname: Tong
authors.forename: Ding-Zhi
authors.initials: DZ
authors.lastname: Ma
authors.forename: Rui-Fen
authors.initials: RF
authors.lastname: Cai
authors.forename: Fu-Song
authors.initials: FS
authors.lastname: Di
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Sha
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017258:Medroxyprogesterone Acetate; C010792:testosterone undecanoate