Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity.
Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.
Bürkle
Alexander
A
Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK. alexander.buerkle@uni-konstanz.de
Beneke
Sascha
S
Brabeck
Christine
C
Leake
Alan
A
Meyer
Ralph
R
Muiras
Marie-Laure
ML
Pfeiffer
Ragen
R
D000375:Aging / Q000235:genetics*; D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D008136:Longevity / Q000235:genetics*; D008322:Mammals / Q000502:physiology*; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology*
D011065:Poly(ADP-ribose) Polymerases