title: [Treatment of hip adductor spasticity with botulinum toxin type B].
abstract: For the treatment of focal spasticity using botulinum toxin, only studies using type A have been published. Botulinum toxin type B (Neurobloc) is registered for cervical dystonia, but there is increasing interest in ist effectiveness for treating other diseases. Four patients, each with seriously disabling hip adductor spasticity of different origins, were treated with botulinum toxin type B following the failure of other therapeutic options. Total doses of 10,000 IU to 22,000 IU were injected bilaterally into the hip adductor muscles. A reduction in muscle tone or painful spasms was observed in all patients within 2 weeks, leading to an improvement in gait and increased ease of nursing care. Therefore, botulinum toxin type B may be a more cost-effective treatment for hip adductor spasticity than botulinum toxin type A.
authors.affiliation: Neurologische Klinik, Justus-Liebig-Universität Giessen. Matthias.Oechsner@neuro.med.uni-giessen.de
authors.forename: M
authors.initials: M
authors.lastname: Oechsner
mesh_terms: D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage*; D019274:Botulinum Toxins, Type A; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006615:Hip; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D009129:Muscle Tonus / Q000187:drug effects; D010264:Paraplegia / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A