[The relationships of PSA, FPSAR, clinical and pathological stage in patients with prostate cancer].
OBJECTIVE
To investigate the relationship between clinical and pathological stage, serum prostate specific antigen (PSA) concentration and free-to-total PSA ratio (FPSAR) in patients with prostate cancer.


METHODS
Clinical and pathological stage were determined on the basis of pathological examination and clinic material in 42 prostate cancer patients treated by prostatectomy. PSA and FPSAR were measured before the operation. Spearman rank correlation was applied to evaluate the relationship between clinical and pathological stage, serum PSA concentration and FPSAR.


RESULTS
Serum PSA concentration was significantly positively correlated with pathological stage(P < 0.05) but not correlated with clinical stage (P > 0.05) in prostate cancer patients. FPSAR was significantly correlated with pathological stage and negatively correlated with clinical stage in prostate cancer patients (P < 0.05).


CONCLUSIONS
FPSAR is a more powerful predictor of clinical stage, pathological stage and prognosis than PSA.
Liu
He-Liang
HL
Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. liuhel@fmmu.edu.cn
Wang
He
H
Yang
Xiao-Jian
XJ
Chen
Bao-Qi
BQ
Qin
Rong-Liang
RL
Shao
Guo-Xing
GX
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology
D017430:Prostate-Specific Antigen