Signaling pathways leading to apoptosis or survival in immature and mature B cells.
In the absence of phosphorylated Gab2, immature B cells are unable to maintain a prolonged signal transduction, which is necessary for the transcriptional regulation and activation of the cells. Thus, the lack of Gab2 phosphorylation may drive immature B cells to apoptosis.
Sármay
G
G
Department of Immunology, Loránd Eötvös University, Budapest, Hungary. sarmayg@cerberus.elte.hu
Koncz
G
G
Bodor
Cs
C
Kövesdi
D
D
Gáti
R
R
Gergely
J
J
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D008213:Lymphocyte Activation; D051379:Mice; D010750:Phosphoproteins / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology*; D013154:Spleen / Q000276:immunology; D014158:Transcription, Genetic
D048868:Adaptor Proteins, Signal Transducing; C490894:Gab2 protein, mouse; D010750:Phosphoproteins; D011947:Receptors, Antigen, B-Cell