title: [Hepatic arterial infusion of IL-2 and chemotherapy for unresectable liver metastasis from colorectal cancer].
abstract: We administered interleukin (IL)-2 with mitomycin C (MMC) and 5-fluorouracil (5-FU) by hepatic arterial infusion for the treatment of liver recurrence from colorectal cancer. The regimen consisted of continuous hepatic arterial infusion of IL-2 (7 x 10(5) JRU/day)/5-FU (250 mg/day) for 4 weeks. After those 4 weeks, a weekly hepatic arterial infusion of IL-2 (2.1 x 10(6) JRU)/5-FU (250 mg) was performed more than 4 weeks. MMC (4 mg) was given as a bolus weekly. This therapy resulted in partial response (PR) in one case, progressive disease (PD) in one case, and no change (NC) in one case. The toxicity of the therapy was a slight in all cases. We herein report 3 patients treated with hepatic arterial infusion of IL-2 with MMC and 5-FU for liver recurrence from colorectal cancer. This therapy may be a new strategy for metastatic colorectal cancer.
authors.affiliation: Dept. of Surgery II, Yamaguchi University School of Medicine.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hazama
authors.forename: Norio
authors.initials: N
authors.lastname: Iizuka
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takano
authors.forename: Kohji
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Akira
authors.initials: A
authors.lastname: Tangoku
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D015996:Survival Rate
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil