The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury.
Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Sequential waves of chemokine expression play a central role in regulating graft injury through the recruitment of phagocytes shortly after transplantation and activated lymphocytes and phagocytes in the weeks and years following transplantation. This review focuses on recent studies demonstrating the role of chemokines in transplantation.
DeVries
Mark E
ME
Department of Immunology, Division of Experimental Therapeutics, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.
Hosiawa
Karoline A
KA
Cameron
Cheryl M
CM
Bosinger
Steven E
SE
Persad
Desmond
D
Kelvin
Alyson A
AA
Coombs
Jeff C
JC
Wang
Hao
H
Zhong
Robert
R
Cameron
Mark J
MJ
Kelvin
David J
DJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D018925:Chemokines / Q000276:immunology*; D002908:Chronic Disease; D020869:Gene Expression Profiling; D006084:Graft Rejection / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*; D014181:Transplantation Immunology; D014764:Viral Proteins / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D018925:Chemokines; D007519:Isoantigens; D019707:Receptors, Chemokine; D014764:Viral Proteins