Molecular recognition--viewed through the eyes of the solvent.
The binding of a ligand L to a specific site on an adsorbent molecule P is usually studied within the lock-and-key model. In this article we argue that the presence of an aqueous solvent may change dramatically the means by which a ligand recognizes its binding site. The main factor, originating from the specific property of water, is the ability of a water molecule to form a hydrogen-bond-bridge between a functional group on L and a functional group on P. This factor will change the criterion for selecting the best binding site.
Ben-Naim
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Department of Physical Chemistry, The Hebrew University, University Plaza, Jerusalem 91904, Israel. arieh@batata.fh.huji.ac.il
D006860:Hydrogen Bonding; D012997:Solvents / Q000737:chemistry*
D012997:Solvents