Specific interactions of complementary mono- and multivalent guests with recognition-induced polymersomes.
We have explored the interactions of mono- and multivalent guests with Recognition-Induced Polymersomes (RIPs) formed from complementary random copolymers featuring diamidopyridine and thymine functionality. Addition of monovalent guests featuring imide functionality to these RIPs induced a temporary swelling of the vesicles, followed by dissociation of the vesicles due to competitive binding of the guest. Conversely, multivalent thymine-functionalized nanoparticle guests were rapidly incorporated into the RIPs, inducing a contraction of RIP diameter over time. These mono- and multivalent interactions were extremely specific: highly analogous control systems showed no interaction with the RIP structures. Taken together, these studies demonstrate highly selective molecular "lock and key" control over higher-order assembly and recognition processes.
Thibault
Raymond J
RJ
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Galow
Trent H
TH
Turnberg
Erik J
EJ
Gray
Mark
M
Hotchkiss
Peter J
PJ
Rotello
Vincent M
VM
D001667:Binding, Competitive; D040761:Biomimetic Materials / Q000737:chemistry; D005415:Flavins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013379:Substrate Specificity; D013941:Thymine / Q000737:chemistry*
D005415:Flavins; D007094:Imides; D011108:Polymers; D011725:Pyridines; D006046:Gold; D013941:Thymine