title: Regional occurrence of plasmid-mediated SHV-7, an extended-spectrum beta-lactamase, in Enterobacter cloacae in Philadelphia Teaching Hospitals.
abstract: Although the production of extended-spectrum beta-lactamases (ESBLs) by Klebsiella pneumoniae and Escherichia coli is an emerging problem, limited data are available regarding the frequency of ESBL production in other organisms. We provide the only description of regional occurrence of SHV-7 in Enterobacteriaceae other than E. coli or K. pneumoniae in the United States, and we emphasize that, among Enterobacter cloacae strains, not all resistance to extended-spectrum cephalosporins is the result of hyperproduction of AmpC beta-lactamase.
authors.affiliation: Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA, USA. ml46@drexel.edu
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Levison
authors.forename: Yamini V
authors.initials: YV
authors.lastname: Mailapur
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Pradhan
authors.forename: George A
authors.initials: GA
authors.lastname: Jacoby
authors.forename: Pamela
authors.initials: P
authors.lastname: Adams
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Emery
authors.forename: Phyllis L
authors.initials: PL
authors.lastname: May
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pitsakis
mesh_terms: D001426:Bacterial Proteins; D018550:Cephalosporin Resistance / Q000502:physiology*; D002511:Cephalosporins / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology*; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests; D015143:Philadelphia; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D002511:Cephalosporins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases