title: Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives.
abstract: 2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.
authors.affiliation: UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay Malabry Cedex, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Cointeaux
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Berrien
authors.forename: Viviane
authors.initials: V
authors.lastname: Peyrou
authors.forename: Olivier
authors.initials: O
authors.lastname: Provot
authors.forename: Liliane
authors.initials: L
authors.lastname: Ciceron
authors.forename: Martin
authors.initials: M
authors.lastname: Danis
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
authors.forename: Joëlle
authors.initials: J
authors.lastname: Mayrargue
mesh_terms: D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008665:Metalloporphyrins / Q000737:chemistry; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D008665:Metalloporphyrins; D010545:Peroxides; D012717:Sesquiterpenes; C041471:manganese tetraphenylporphyrin; C031327:artemisinin