[Risk factors for permanent kidney damage in children with urinary tract infection].
BACKGROUND
In children, urinary tract infection (UTI) is a very common disease, and can cause permanent kidney damage.


OBJECTIVE
To determine risk factors for permanent kidney damage, in children with UTI.


METHODS
In 337 children with UTI (237 female, mean age 4.2 years) a static renal scintigraphy was performed to assess the presence of permanent kidney damage. The history of vesicoureteral reflux and number of episodes of UTI was obtained.


RESULTS
One hundred three children had a history of one episode of infection and the rest had recurrent infections. Permanent kidney damage was observed in 161 children (48%). This damage was observed in 39% of children of less than one year of age, in 43% of children aged 1 to 5 years of age and in 58% of children older than 5 years (p = 0.02). Sixty three percent of 122 children with vesicoureteral reflux had permanent kidney damage, compared with 27% of children without this condition (p < 0.001). Likewise, damage was observed in 36% of children with one episode of infection and 47% of children with recurrent infections (p < 0.01). No gender differences were observed.


CONCLUSIONS
Vesicoureteral reflux, recurrence of UTI and age are associated with permanent renal damage in children with UTI.
Orellana
Pilar
P
Departamentos de Radiología, Pediatría, Urología, Laboratorio de Medicina Nuclear, Salud Pública, Hospital Clínico, Facultad de Medicina, Pontificia Universidad Católica de Chile. pilar@med.puc.cl
Cavagnaro
Felipe
F
Baquedano
Paulina
P
Lagomarsino
Edda
E
García
Cristián
C
Villarroel
Luis
L
Carreño
Juan Eduardo
JE
Meneses
Luis
L
D017677:Age Distribution; D000367:Age Factors; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011877:Radionuclide Imaging; D012008:Recurrence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000000981:diagnostic imaging / Q000209:etiology*