title: Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia.
abstract: Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non-Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high-risk haplotype were older than patients with low-risk haplotype (P = 0.024). No statistically significant associations were found between TNF haplotype and sex, WBC counts, central nervous system involvement, immunophenotype, response to chemotherapy, and event-free survival. These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL.
authors.affiliation: Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA. takeuti@kochi-ms.ac.jp
authors.forename: Seisho
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Claus R
authors.initials: CR
authors.lastname: Bartram
authors.forename: Martin
authors.initials: M
authors.lastname: Zimmermann
authors.forename: Martin
authors.initials: M
authors.lastname: Schrappe
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Taguchi
authors.forename: H Phillip
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D000367:Age Factors; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006239:Haplotypes; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D011379:Prognosis; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha