title: Endogenous pro-inflammatory cytokines in children and adolescents during chemotherapy-induced neutropenia.
abstract: Monocyte-derived pro-inflammatory cytokines such as GM-CSF, IL-12, and IP-10 might protect patients with chemotherapy-induced neutropenia against infections. In settings with abundant neutrophils, G-CSF has been described as a suppressor of IL-12, but also as an inducer of GM-CSF. In 25 pediatric patients with chemotherapy-induced neutropenia the authors measured plasma levels of these four cytokines. GM-CSF was detectable in only a minority of patients (6/25). It was, however, positively correlated with high plasma levels of IL-12 and IP-10. G-CSF levels, however, were in no way correlated with the levels of any of these three cytokines.
authors.affiliation: University of Leipzig Medical Center, Department of Pediatrics, Leipzig, Germany. banu@medizin.uni-leipzig.de
authors.forename: U
authors.initials: U
authors.lastname: Banning
authors.forename: C
authors.initials: C
authors.lastname: Mauz-Körholz
authors.forename: Q
authors.initials: Q
authors.lastname: Muhammad
authors.forename: A
authors.initials: A
authors.lastname: Kösser
authors.forename: A E
authors.initials: AE
authors.lastname: Müller
authors.forename: U
authors.initials: U
authors.lastname: Tunn
authors.forename: K
authors.initials: K
authors.lastname: Rieske
authors.forename: H
authors.initials: H
authors.lastname: Bönig
authors.forename: D
authors.initials: D
authors.lastname: Körholz
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D054357:Chemokine CXCL10 / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood*; D018664:Interleukin-12 / Q000097:blood; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D009503:Neutropenia / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D054357:Chemokine CXCL10; D016207:Cytokines; D018836:Inflammation Mediators; D016179:Granulocyte Colony-Stimulating Factor; D018664:Interleukin-12; D016178:Granulocyte-Macrophage Colony-Stimulating Factor