Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.
Lewis
Warren G
WG
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Green
Luke G
LG
Grynszpan
Flavio
F
Radić
Zoran
Z
Carlier
Paul R
PR
Taylor
Palmer
P
Finn
M G
MG
Sharpless
K Barry
KB
D000110:Acetylcholinesterase / Q000737:chemistry*; D000818:Animals; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D007700:Kinetics; D051379:Mice; D014101:Torpedo
D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase