Gammadelta T lymphocytosis associated with granulomatous disease in a patient with common variable immunodeficiency.
Common variable immunodeficiency (CVID) is a heterogeneous group of immunodeficiency syndromes that involves defective production of specific antibodies and decreased serum concentrations of > or =1 immunoglobulin isotype. We describe a patient with an atypical case of CVID who had extensive granulomatous lesions that were partially attributable to mycobacterial infection. In the peripheral blood, there was a massive increase in the number of double-negative CD3+ T cells that expressed the gammadelta T cell receptor.
Viallard
Jean-François
JF
Clinique de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévêque, Centre François-Magendie, 33604 Pessac, France. jean-francois.viallard@chu-bordeaux.fr
Bloch-Michel
Coralie
C
Caubet
Olivier
O
Parrens
Marie
M
Texier-Maugein
Jeannette
J
Neau-Cransac
Martine
M
Taupin
Jean-Luc
JL
Moreau
Jean-François
JF
Pellegrin
Jean-Luc
JL
D000328:Adult; D017252:CD3 Complex / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D008218:Lymphocytosis / Q000150:complications* / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology
D017252:CD3 Complex; D016692:Receptors, Antigen, T-Cell, gamma-delta