Metabolic and immunological effects of antiretroviral agents in healthy individuals receiving post-exposure prophylaxis.
We have assessed metabolic and immunological effects of a nelfinavir-containing regimen in healthy HIV-1-uninfected individuals receiving post-exposure prophylaxis. Our data suggest that this regimen is well tolerated and did not modify the lipid or hepatic profiles. This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens.
Garcia
Felipe
F
Infectious Diseases Unit, University of Barcelona, Barcelona, Spain. fgarcia@medicina.ub.es
Plana
Montserrat
M
Mestre
Gabriel
G
Cruceta
Anna
A
Martinez
Esteban
E
Miró
José M
JM
Mallolas
Josep
J
Tuset
Montserrat
M
Pumorola
Tomas
T
Gallart
Teresa
T
Gatell
José M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D019380:Anti-HIV Agents