Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods.
Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Diplopoda). They were grown in submerged culture and investigated by biological assays and HPLC-diode array analysis regarding their production of bioactive metabolites, which were isolated and determined in structure. Known compounds and yet unknown derivatives from the primary metabolism were detected, as well as antibacterially and antifungally acting peptide antibiotics.
Gebhardt
Klaus
K
Mikrobiologisches Institut, Universität Tübingen, D-72076 Tübingen, Germany.
Schimana
Judith
J
Müller
Johannes
J
Fiedler
Hans-Peter
HP
Kallenborn
Helmut G
HG
Holzenkämpfer
Meike
M
Krastel
Philipp
P
Zeeck
Axel
A
Vater
Joachim
J
Höltzel
Alexandra
A
Schmid
Dietmar G
DG
Rheinheimer
Joachim
J
Dettner
Konrad
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000145:classification / Q000302:isolation & purification; D023181:Antimicrobial Cationic Peptides; D001181:Arthropods / Q000033:anatomy & histology / Q000145:classification / Q000382:microbiology*; D001407:Bacillus / Q000737:chemistry* / Q000302:isolation & purification; D001414:Bacitracin / Q000302:isolation & purification; D006540:Herbicides / Q000145:classification / Q000302:isolation & purification; D019271:Hypoxanthine / Q000302:isolation & purification; D008958:Models, Molecular; D010455:Peptides; D013559:Symbiosis; D014363:Tryptamines / Q000302:isolation & purification; D014498:Uracil / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D006540:Herbicides; D010455:Peptides; D014363:Tryptamines; D001414:Bacitracin; D019271:Hypoxanthine; C030820:tryptamine; D014498:Uracil; C027845:bacillomycin D