[Poisonings with psychotropic drug mixtures: analysis using the thin-layer chromatography method].
It is observed increase in number of remedy intoxications in Lithuania, especially important is intoxication with psychotropic drugs and their mixtures. The thin-layer chromatography (TLC) method was proposed for separation and identification of drugs in mixture aminazine: nitrazepam: barbamylum. The mixture of these drugs excreted from body fluids (blood and urine) was investigated by TLC. Most acceptable these mobile phases: 1. Diethyl ether: dioxane--40:60. Rf values for drugs: aminazine 0.23-0.25; barbamylum 0.85-0.9; nitrazepam 0.75-0.8. 2. Diethyl ether: NH3 (25%): benzenum--80:10:10. Rf values for drugs: aminazine 0.55-0.58; barbamylum 0.32-0.35; nitrazepam 0.17-0.2.
Kiliuviene
Guoda
G
Kauno medicinos universiteto Analizines ir toksikologines chemijos katedra, Mickeviciaus 9, 3000 Kaunas.
Vainauskas
Paulius
P
Zevzikovas
Andrejus
A
Dirse
Vidmantas
V
D000654:Amobarbital / Q000032:analysis; D014151:Anti-Anxiety Agents / Q000032:analysis; D014150:Antipsychotic Agents / Q000032:analysis; D002746:Chlorpromazine / Q000032:analysis; D002855:Chromatography, Thin Layer; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis; D007202:Indicators and Reagents; D008962:Models, Theoretical; D009567:Nitrazepam / Q000032:analysis; D011619:Psychotropic Drugs / Q000032:analysis* / Q000506:poisoning*
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D011619:Psychotropic Drugs; D009567:Nitrazepam; D000654:Amobarbital; D002746:Chlorpromazine