Antithrombin activity of some constituents from Origanum vulgare.
Aristolochic acid I, aristolochic acid II, and D-(+)-raffinose were isolated from Origanum vulgare. Their inhibition of thrombin and activity against leukemia were evaluated. Aristolochic acid I and II have high inhibition of thrombin activity and were confirmed to possess activity against cancer.
Goun
E
E
Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA.
Cunningham
G
G
Solodnikov
S
S
Krasnykch
O
O
Miles
H
H
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000991:Antithrombins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D034341:Aristolochic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007938:Leukemia / Q000473:pathology; D015394:Molecular Structure; D031341:Origanum / Q000737:chemistry*; D011887:Raffinose / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000097245:Ursolic Acid
D000970:Antineoplastic Agents; D000991:Antithrombins; D034341:Aristolochic Acids; D011887:Raffinose; D014315:Triterpenes; D000097245:Ursolic Acid; C000228:aristolochic acid I; C042310:aristolochic acid II