Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction.
We review evidence for two models of hemispheric asymmetry and aging: the right hemi-aging model, which proposes that the right hemisphere shows greater age-related decline than the left hemisphere, and the hemispheric asymmetry reduction in old adults (HAROLD) model, which proposes that frontal activity during cognitive performance tends to be less lateralized in older than in younger adults. The right hemi-aging model is supported by behavioral studies in the domains of cognitive, affective, and sensorimotor processing, but the evidence has been mixed. In contrast, available evidence is generally consistent with the HAROLD model, which is supported primarily by functional neuroimaging evidence in the domains of episodic memory encoding and retrieval, semantic memory retrieval, working memory, perception, and inhibitory control. Age-related asymmetry reductions may reflect functional compensation or dedifferentiation, and the evidence, although scarce, tends to support the compensation hypothesis. The right hemi-aging and the HAROLD models are not incompatible. For example, the latter may apply to prefrontal regions and the former to other brain regions.
Dolcos
Florin
F
Center for Cognitive Neuroscience, Duke University, PO Box 90999 (or LSRC Building, Room B203), Durham, NC 27708, USA. fdolcos@duke.edu
Rice
Heather J
HJ
Cabeza
Roberto
R
D000375:Aging / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D003952:Diagnostic Imaging; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology; D008606:Mental Processes / Q000502:physiology*; D008954:Models, Biological; D010465:Perception / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology / Q000503:physiopathology; D011597:Psychomotor Performance; D013028:Space Perception / Q000502:physiology; D014706:Verbal Learning / Q000502:physiology