Comparison of calcium alginate film with collagen membrane for guided bone regeneration in mandibular defects in rabbits.
OBJECTIVE
We sought to compare calcium alginate film (CAF) with collagen membrane (CM) regarding their effects on guided bone regeneration.


METHODS
Circular bone defects with 5-mm diameter were created in the region anterior to both mandibular angles in 34 rabbits. The defects on one side were covered with a CAF, and the contralateral side with CM. Healing condition was analyzed with gross, radiographic, electromicroscopic, histologic, and immunohistochemical studies and image pattern analysis system after 1, 2, 4, 6, and 8 weeks.


RESULTS
CM absorbed more slowly but collected fewer osteoinductive factors (P <.05) in the early period. CAF induced dense bone formation, whereas CM produced less newly formed bone.


CONCLUSIONS
CAF is more efficacious than CM in guided bone regeneration in this animal model.
Jianqi
Huang
H
Received from the Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Medical College, Zhe Jiang University, Hang Zhou, China.
Hong
He
H
Lieping
Sheng
S
Genghua
Gu
G
D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D003094:Collagen; D020723:Glucuronic Acid; D048091:Guided Tissue Regeneration / Q000379:methods*; D006603:Hexuronic Acids; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011817:Rabbits
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D020723:Glucuronic Acid; D003094:Collagen