Sensitive through-space dipolar correlations between nuclei of small organic molecules by partial alignment in a deuterated liquid solvent.
Through-space residual dipolar correlations in NMR spectra can be measured between nuclei of small organic molecules by partially aligning them with respect to the magnetic field in a pure deuterated liquid solvent, 4-pentyl-4'-cyanobiphenyl. A simple temperature change of this liquid phase enables spectra to be compared between samples under isotropic tumbling conditions and weakly oriented anisotropic states. This should provide access of a number of small nonpolar molecules to more sensitive through-space nuclear correlations than possible through NOE experiments, depending on the net orientation of specific nuclear pairs with respect to the magnetic field and the specific coherence transfers employed.
Bendiak
Brad
B
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Campus Box B111, 4200 East Ninth Avenue, Denver, CO 80262, USA. brad.bendiak@uchsc.edu
D016880:Anisotropy; D001713:Biphenyl Compounds / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009570:Nitriles / Q000737:chemistry; D010616:Phenanthrenes / Q000737:chemistry; D012680:Sensitivity and Specificity; D012997:Solvents
D001713:Biphenyl Compounds; D009570:Nitriles; D010616:Phenanthrenes; D012997:Solvents; C433919:4-cyano-4'-pentylbiphenyl; D003903:Deuterium