title: Gadopentetate dimeglumine is potentially an alternative contrast agent for three-dimensional computed tomography angiography with multidetector-row helical scanning.
abstract: OBJECTIVE
  To demonstrate that gadopentetate dimeglumine is potentially an alternative contrast medium for computed tomographic angiography (CTA).
  
  
  METHODS
  One 12.2-kg Beagle dog was studied as proof of principle; the cervical vessels of three adult human patients were imaged for presurgical planning of the neck. Gadopentetate dimeglumine, 0.5 mol/l (Berlex Laboratories, Wayne, NJ, U.S.A.), a LightSpeed QX/i CT (General Electric Medical Systems, Milwaukee, WI, U.S.A.), and an Ultra Sparc II (SUN Microsystems, Santa Clara, CA, U.S.A.) running Advantage Windows 3.1 (General Electric Medical Systems) were used.
  
  
  RESULTS
  Sufficient enhancement for CTA of the thoracic aorta, cervical vessels, and abdominal vessels was produced in the experimental dog, and the cervical vessels were clearly defined in all three patients.
  
  
  CONCLUSIONS
  In that subset of patients with contraindications to iodinated contrast medium and for whom magnetic resonance angiography is inappropriate, gadopentetate dimeglumine may be an alternative contrast medium for CTA.
authors.affiliation: Department of Radiology, The Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. atul.gupta@roswellpark.org
authors.forename: Atul K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Alberico
authors.forename: Alan
authors.initials: A
authors.lastname: Litwin
authors.forename: Peter
authors.initials: P
authors.lastname: Kanter
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Grossman
mesh_terms: D000792:Angiography / Q000379:methods* / Q000662:veterinary; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004285:Dogs; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D021621:Imaging, Three-Dimensional; D009333:Neck / Q000098:blood supply; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000662:veterinary
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA