Synthesis of 2-arylbenzo[b]furans via copper(I)-catalyzed coupling of o-iodophenols and aryl acetylenes.
[reaction: see text] We report a copper(I)-catalyzed procedure for the synthesis of 2-arylbenzo[b]furans. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans in good to excellent yields. This method can tolerate a variety of functional groups, does not require the use of expensive additives, and is palladium-free.
Bates
Craig G
CG
Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Saejueng
Pranorm
P
Murphy
Jaclyn M
JM
Venkataraman
D
D
D000480:Alkynes / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry
D000480:Alkynes; D001572:Benzofurans; D007462:Iodobenzenes; D003300:Copper