title: Moving across membranes.
abstract: Protein toxins are known to translocate through intracellular membranes to reach their cytosolic targets. Results from studies with botulinum neurotoxin suggest that the toxin heavy chain functions as both a channel and a chaperone for translocation of the catalytically active light chain.
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Neale
mesh_terms: D000818:Animals; D001905:Botulinum Toxins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D009498:Neurotoxins / Q000737:chemistry / Q000378:metabolism; D021381:Protein Transport
chemical_list: D009498:Neurotoxins; D001905:Botulinum Toxins