Intracellular lipid binding proteins of the small intestine.
The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the small intestine has remained enigmatic. Targeted gene disruption studies may shed insights into the physiological importance of these proteins. In the case of I-FABP, this approach has demonstrated that the complete elimination of this protein in murine intestine does not compromise dietary fat absorption in vivo but is associated with the development of insulin resistance.
Agellon
Luis B
LB
Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, Department of Biochemistry, University of Alberta, Edmonton, Canada. luis.agellon@ualberta.ca
Toth
Matthew J
MJ
Thomson
Alan B R
AB
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D007408:Intestinal Absorption / Q000502:physiology; D007421:Intestine, Small / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins
D002352:Carrier Proteins; D004041:Dietary Fats; C493320:Fabp1 protein, mouse; C082667:Fabp5 protein, mouse; C086936:Fabp7 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins