title: [Antihypertensive drugs and malignant neoplasia].
abstract: Analysis of epidemiological, cohort and randomized studies of antihypertensive drugs containing reports of development of malignant neoplasms shows that long term use of some antihypertensive drugs while preventing cardiovascular complications has been associated with increased risk of malignancies. Most convincing evidence exists for association between the use of diuretics and renal cancer. Association between the use of reserpine and breast cancer in women, between atenolol and some types of cancer in elderly men also can not be ruled out. There is no proof of existence of either negative or positive correlation between malignant neoplasia and long-term use of calcium antagonists, angiotensin converting enzyme inhibitors or angiotensin receptor blockers.
authors.forename: D V
authors.initials: DV
authors.lastname: Preobrazhenskiĭ
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.forename: T M
authors.initials: TM
authors.lastname: Stetsenko
authors.forename: V G
authors.initials: VG
authors.lastname: Kiktev
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000367:Age Factors; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001262:Atenolol / Q000009:adverse effects; D001581:Benzothiadiazines; D001943:Breast Neoplasms / Q000139:chemically induced; D002121:Calcium Channel Blockers / Q000009:adverse effects; D015331:Cohort Studies; D004232:Diuretics; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced; D008297:Male; D009369:Neoplasms / Q000139:chemically induced*; D016032:Randomized Controlled Trials as Topic; D012110:Reserpine / Q000009:adverse effects; D012307:Risk Factors; D012737:Sex Factors; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013997:Time Factors
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D002121:Calcium Channel Blockers; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D001262:Atenolol; D012110:Reserpine