[Safety of celecoxib administration].
Celecoxib is selective cylooxygenase-2 (COX-2) inhibitor with equal efficacy like conventional non-steroidal antiinflammatory drugs (NSAIDs). The main advantage is safer gastrointestinal (GI) profile. All other adverse effects of celecoxib are comparable with NSAIDs adverse reactions. Clinical studies in thousands of patients show convincing evidence of GI safety in total number of GI events. The serious GI complications could not be excluded regarding safety. There is no antithrombotic effect and caution is required in elderly, hypertension, oedema, vascular and ulcer diseases. Cardioprotective aspirin therapy may be indicated in persons with cardiovascular risk. Celecoxib is contraindicated in people with known allergy on sulfonamides. The caution is needed in any NSAIDs allergy.
Babić-Naglić
Durdica
D
Klinika za reumatske bolesti i rehabilitaciju, KBC Zagreb, Kispatićeva 12, 10000 Zagreb.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D000068579:Celecoxib; D000075202:Contraindications; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib