Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis.
Cerebrospinal fluid (CSF) analysis of pterin and monamine metabolites was performed before and after an attack in a patient with paroxysmal exercise-induced dystonia. A twofold increase in CSF homovanillic acid and 5-hydroxyindoleacetic acid after an attack was measured. This finding lends support to the hypothesis that increased dopaminergic transmission contributes to the clinical features of the hyperkinetic movement disorders.
Barnett
Michael H
MH
National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, United Kingdom.
Jarman
Paul R
PR
Heales
Simon J R
SJ
Bhatia
Kailash P
KP
D000328:Adult; D004298:Dopamine / Q000502:physiology*; D004421:Dystonia / Q000175:diagnosis / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D009460:Neurologic Examination; D009435:Synaptic Transmission / Q000502:physiology
D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid