Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process.
[reaction: see text] The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14-C26 segment of halichondrins has been developed.
Choi
Hyeong-Wook
HW
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Nakajima
Katsumasa
K
Demeke
Damtew
D
Kang
Fu-An
FA
Jun
Hyuk-Sang
HS
Wan
Zhao-Kui
ZK
Kishi
Yoshito
Y
D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
D004988:Ethers, Cyclic; D002857:Chromium; D009532:Nickel