Bilateral exopthalmus due to retro-orbital chloromas in a boy with t(8;21)- positive acute myeloblastic acute leukemia.
Exophthalmus is an infrequent finding in pediatrics. The differential diagnoses include chloromas, tumors of immature hematopoietic precursor cells. The case of a child with acute myeloid leukemia is reported. The presenting signs had included exophthalmus and nasal speech due to retro-orbital and sinusoidal chloromas, respectively. As in most cases of pediatric acute myeloid leukemia with chloroma, the AML1/ETO fusion gene was found, which portended a not unfavorable prognosis. This child was treated according to the AML-BFM 98 protocol and achieved an ongoing remission. The exophthalmus resolved completely.
Bönig
H
H
Department of Pediatric Hematology and Oncology, Heinrich-Heine University Center of Child Health, Düsseldorf, Germany.
Göbel
U
U
Nürnberger
W
W
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005094:Exophthalmos / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000150:complications / Q000175:diagnosis*; D012074:Remission Induction; D023981:Sarcoma, Myeloid; D014178:Translocation, Genetic
D000970:Antineoplastic Agents