title: The efficacy of intravitreal levofloxacin and intravitreal dexamethasone in experimental Staphylococcus epidermidis endophthalmitis.
abstract: This study was designed to investigate the efficacy of intravitreal levofloxacin, and intravitreal levofloxacin and dexamethasone combined in Staphylococcus epidermidis endophthalmitis. Albino rabbits (n = 25), infected with an intravitreal inoculum of S. epidermidis (1.0 x 10(5) colony forming units/0.1 ml), were divided into five groups (n = 5). Groups 1 and 2 received treatment 24 h after the inoculation, and groups 3 and 4 48 h after the inoculation. No treatment was given to the control group. Treatment efficacy was assessed by vitreous culture, clinical examination and histopathology. Five days after treatment, groups 1 and 2 had significantly lower clinical scores than the control group (p = 0.004, p = 0.007). The culture results of the treatment groups were sterile. The histopathological scores of the treatment groups were lower than the control group (p = 0.007). Studies on retinal toxicity and dose-response relation are needed to prove the efficacy of levofloxacin in S. epidermidis endophthalmitis.
authors.affiliation: Department of Ophthalmology, Mersin University Faculty of Medicine, Mersin, Turkey. dryildirimoz@hotmail.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yildirim
authors.forename: Ozay
authors.initials: O
authors.lastname: Oz
authors.forename: Gönül
authors.initials: G
authors.lastname: Aslan
authors.forename: Leyla
authors.initials: L
authors.lastname: Cinel
authors.forename: Nuran
authors.initials: N
authors.lastname: Delialioğlu
authors.forename: Arzu
authors.initials: A
authors.lastname: Kanik
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D064704:Levofloxacin; D015242:Ofloxacin / Q000627:therapeutic use*; D011817:Rabbits; D013212:Staphylococcus epidermidis; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D064704:Levofloxacin; D003907:Dexamethasone; D015242:Ofloxacin