title: Genetic association analysis using microsatellite markers in atopic dermatitis.
abstract: Atopic dermatitis (AD) is presumed to be influenced by genetic and environmental factors. In this study, 54 patients with AD were examined for disease association by the use of 12 microsatellite markers. Several significant associations were recognized in the alleles on chromosome 5, 7 and 11. AD genes were mapped near the FC epsilon RI beta gene (around D11S1314 locus) on chromosome 11, the IL4 gene cluster on chromosome 5 and the TCR gamma gene on chromosome 7. This distribution in close proximity to candidate loci for AD is very similar to that of atopic genes, therefore implying that an atopic trait is genetically responsible for the development of AD.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. iizuka@is.icc.u-tokai.ac.jp
authors.forename: Mariko
authors.initials: M
authors.lastname: Iizuka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Umezawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Hisako
authors.initials: H
authors.lastname: Kawada
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Eishin
authors.initials: E
authors.lastname: Morita
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D007564:Japan; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers