[Effect of gamma-aminobutyric acid on the sperm acrosin activity].
OBJECTIVE
To investigate the effect of gamma-aminobutyric acid (GABA) on the sperm acrosin activity in normal men and positive antisperm antibody (AsAb) men.


METHODS
Sperm acrosin activity was detected by BAEE/ADH method.


RESULTS
GABA could increase the sperm acrosin activity in normal and AsAb positive patients (P < 0.01). The results also indicated that GABA significantly increased Na(+)-K(+)-ATPase activity (P < 0.01), Ca(2+)-ATPase activity (P < 0.05) and SOD activity (P < 0.01) of sperm.


CONCLUSIONS
The results demonstrated that GABA could influence the sperm acrosin activity.
Bian
Shu-Ling
SL
Department of Physiology, Harbin Medical University, Harbin, Heilongjiang 150086, China.
Zhang
Wei
W
Zhu
Hui
H
Ni
Jiang
J
Yao
Lan-Chun
LC
Chen
Liang
L
D000176:Acrosin / Q000378:metabolism*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D000176:Acrosin