title: Preservation of hippocampal neuron numbers in aged rhesus monkeys.
abstract: To investigate whether or not aging of nonhuman primates is accompanied by a region-specific neuron loss in the hippocampal formation, we used the optical fractionator technique to obtain stereological estimates of unilateral neuron numbers of the hippocampi of eight young (0-4 years) and five aged (18-31 years) male rhesus monkeys (Macaca mulatta). Our results show a preservation of neurons (mean x 10 (3)+/-S.D.x10(3)) in the subiculum (young=588+/-124, aged=612+/-207), CA1 (young=1051+/-249, aged=1318+/-311), CA2 (young=100+/-18, aged=113+/-12), CA3 (young=478+/-125, aged=509+/-139), hilus (young=337+/-115, aged=394+/-90), and dentate gyrus (young=5550+/-1725, aged=7799+/-2087) of the hippocampal formation. These results confirm a previous stereological study in rhesus monkeys, but are in conflict with data for humans, showing age-dependent region-specific alterations in the hippocampal formation.
authors.affiliation: Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077, Göttingen, Germany. jkeuker@www.dpz.gwdg.de
authors.forename: Jeanine I H
authors.initials: JI
authors.lastname: Keuker
authors.forename: Paul G M
authors.initials: PG
authors.lastname: Luiten
authors.forename: Eberhard
authors.initials: E
authors.lastname: Fuchs
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002452:Cell Count; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology*