T-bet as a possible therapeutic target in autoimmune disease.
The prominent role of pro-inflammatory cytokines produced by T helper-1 (T(H1)) cells in regulating autoimmune responses in vitro and in vivo has been demonstrated. Recent observations of T cell polarisation by regulatory transcription factors--especially T-bet (T-box expressed in T cells)--raise the question of their influence in controlling autoimmune diseases. Here, the authors summarise recent observations of the role of T-bet in controlling chronic inflammatory and autoimmune diseases and discuss the implications of these findings for future therapeutic approaches.
Weigmann
Benno
B
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. neurath@1-med.klinik.uni-mainz.de
Neurath
Markus F
MF
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D002446:Celiac Disease / Q000276:immunology; D002454:Cell Differentiation; D003092:Colitis / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D004195:Disease Models, Animal; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D007371:Interferon-gamma / Q000502:physiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D019463:Mice, Inbred MRL lpr / Q000276:immunology; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020825:T-Box Domain Proteins; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000172:deficiency / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects; D000098815:T-bet Transcription Factor
D016207:Cytokines; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors; D007371:Interferon-gamma