SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain.
I describe the characterization of mouse, human and chicken SSDP1 orthologs that encode a highly conserved protein with over 90% identity at the amino acid level. Structurally, the protein consists of a well-preserved FWD (FORWARD)-domain at the N-terminal end and a proline-, glycine-, methionine- and serine-rich sequence in the central and C-terminal regions. The FORWARD domain, comprised of three alpha-helices, is characterized by the presence of a FWD-box of unknown function conserved not only in vertebrates, but also in nematode, plants, fly and yeast. Human SSDP1 spans about 200 kb on the chromosome 1p31-p32 region and consists of 17 exons. The SSDP1 mRNA transcripts are distributed ubiquitously in adult human and mouse tissues.
Bayarsaihan
Dashzeveg
D
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. bayarsaihan@yale.edu
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern / Q000379:methods; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein
D004268:DNA-Binding Proteins