title: Asymmetric carbon-carbon bond-forming reaction at the 2-position of a piperidine skeleton.
abstract: An asymmetric carbon-carbon bond-forming reaction at the 2-position of a piperidine skeleton was exploited. This method consisted of a reaction between 1-(4-methoxybenzoyl)-3,4-didehydro-2-methoxypiperidines and dimethyl malonate catalyzed by Cu(II)-chiral 2,2'-isopropylidenebis(4-phenyl-2-oxazoline) to afford a 2-substituted piperidine skeleton with moderate enantioselectivity.
authors.affiliation: Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Kanda
authors.forename: Osamu
authors.initials: O
authors.lastname: Onomura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Maki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsumura
mesh_terms: D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D010880:Piperidines