Immunogenicity and safety of an adjuvanted influenza vaccine in patients with decompensated cirrhosis.
The immunogenicity and tolerability of an adjuvanted trivalent influenza vaccine was evaluated in 20 patients with cirrhosis due to chronic HBV or HCV infections and eight healthy age matched controls. Seroconversion or a four-fold or greater increase in HI antibody titres to each antigen occurred in 75-85% of the patients and in 100% of the controls. One month after vaccination, the geometric mean antibody titres were significantly higher than baseline in both groups of vaccinees. A mild and transient erythema at the inoculation site was the only side effect for both groups. The results justify the use of an adjuvanted influenza vaccine, given as single-dose, in patients with advanced liver disease.
Gaeta
Giovanni B
GB
Unit of Infectious Diseases, Second University of Naples, Naples, Italy.
Stornaiuolo
Gianfranca
G
Precone
Davide F
DF
Amendola
Antonella
A
Zanetti
Alessandro R
AR
D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006679:HIV Seropositivity / Q000150:complications; D006506:Hepatitis A / Q000150:complications; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D022721:Vaccines, Virosome / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D022721:Vaccines, Virosome