Co-transcriptional monitoring of mRNP formation.
In eukaryotes, newly manufactured mRNA is subject to strict quality control. If certain standards are not met, offending messages are retained in the nucleus and degraded by the exosome complex. New data suggest that exosome-mediated processes are intimately coupled to the transcription machinery, which makes the mRNA in the first place.
Jensen
Torben Heick
TH
Rosbash
Michael
M
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*
D012333:RNA, Messenger