title: [Pharmacological study on levofolinate in intraperitoneal leucovorin-5-FU chemotherapy].
abstract: We report the pharmacological findings on levofolinate after the intraperitoneal administration of leucovorin-5-FU. Levofolinate 300 mg/saline 500 ml and 5-FU 750 mg/saline 500 ml were administered intraperitoneally over 1.5 h. The plasma and intraperitoneal concentrations of levofolinate at 0, 0.5, 1, 2, 4, 8, 22(20) h after the administration were evaluated at 6 points with HPLC analysis. The intraperitoneal levofolinate concentration went up as high as 100 micrograms/ml and remained above 10 micrograms/ml over 8 hours. This suggested that intraperitoneal administration elevated the portal vein and abdominal lymphatic levofolinate levels. Intraperitoneal levofolinate-5-FU is a promising protocol for gastro-intestinal cancers.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ebuchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagahama
authors.forename: Itaru
authors.initials: I
authors.lastname: Takashima
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Takanori
authors.initials: T
authors.lastname: Ochiai
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Natsui
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015918:Infusion Pumps, Implantable; D007263:Infusions, Parenteral / Q000295:instrumentation; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged
chemical_list: D002955:Leucovorin; D005472:Fluorouracil