title: Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis.
abstract: A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450(aldo) and P450(11beta), causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.
authors.affiliation: Department of Internal Medicine, Misato Kenwa Hospital, Saitama.
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masakazu
authors.initials: M
authors.lastname: Izeki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Horigome
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoneda
authors.forename: Shizuo
authors.initials: S
authors.lastname: Tsuyuki
authors.forename: Shigeto
authors.initials: S
authors.lastname: Takami
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications*; D018246:Adrenocortical Adenoma / Q000150:complications*; D000328:Adult; D003480:Cushing Syndrome / Q000150:complications / Q000209:etiology*; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000209:etiology*; D013967:Thyroiditis, Autoimmune / Q000150:complications*