Multiple redox regulation of the cellular signaling system linked to AP-1 and NFkappaB: effects of N-acetylcysteine and H2O2 on the receptor tyrosine kinases, the MAP kinase cascade, and IkappaB kinases.
Kamata
Hideaki
H
Department of Life Science, Faculty of Science, Himeji Institute of Technology, Ako-gun, Hyogo 678-1297, Japan. h.kamata@sci.himeji-tech.ac.jp
Manabe
Tomoyuki
T
Kakuta
Jungo
J
Oka
Shin-Ichi
S
Hirata
Hajime
H
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D051550:I-kappa B Kinase; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D016328:NF-kappa B / Q000378:metabolism*; D010084:Oxidation-Reduction; D016716:PC12 Cells; D010673:Pheochromocytoma; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D016328:NF-kappa B; D018808:Transcription Factor AP-1; D006861:Hydrogen Peroxide; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase; D000111:Acetylcysteine