title: Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis.
abstract: It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.
authors.affiliation: Biomembranes et Messagers Cellulaires, CNRS -UMR 8619, Université Paris XI, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lépine
authors.forename: Boris
authors.initials: B
authors.lastname: Lakatos
authors.forename: Pierre
authors.initials: P
authors.lastname: Maziere
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Courageot
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Sulpice
authors.forename: Françoise
authors.initials: F
authors.lastname: Giraud
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002518:Ceramides / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013110:Sphingosine / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*
chemical_list: D002518:Ceramides; D003907:Dexamethasone; D013108:Sphingomyelin Phosphodiesterase; D013110:Sphingosine