title: Autonomic nervous system testing may not distinguish multiple system atrophy from Parkinson's disease.
abstract: BACKGROUND
  Formal laboratory testing of autonomic function is reported to distinguish between patients with Parkinson's disease and those with multiple system atrophy (MSA), but such studies segregate patients according to clinical criteria that select those with autonomic dysfunction for the MSA category.
  
  
  OBJECTIVE
  To characterise the profiles of autonomic disturbances in patients in whom the diagnosis of Parkinson's disease or MSA used criteria other than autonomic dysfunction.
  
  
  METHODS
  47 patients with parkinsonism and autonomic symptoms who had undergone autonomic laboratory testing were identified and their case records reviewed for non-autonomic features. They were classified clinically into three diagnostic groups: Parkinson's disease (19), MSA (14), and uncertain (14). The performance of the patients with Parkinson's disease was compared with that of the MSA patients on five autonomic tests: RR variation on deep breathing, heart rate changes with the Valsalva manoeuvre, tilt table testing, the sudomotor axon reflex test, and thermoregulatory sweat testing.
  
  
  RESULTS
  None of the tests distinguished one group from the other with any statistical significance, alone or in combination. Parkinson's disease and MSA patients showed similar patterns of autonomic dysfunction on formal testing of cardiac sympathetic and parasympathetic, vasomotor, and central and peripheral sudomotor functions.
  
  
  CONCLUSIONS
  This study supports the clinical observation that Parkinson's disease is often indistinguishable from MSA when it involves the autonomic nervous system. The clinical combination of parkinsonism and dysautonomia is as likely to be caused by Parkinson's disease as by MSA. Current clinical criteria for Parkinson's disease and MSA that direct patients with dysautonomia into the MSA group may be inappropriate.
authors.affiliation: Department of Neurology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, 1100 Euclid Avenue, Cleveland, OH 44106, USA. david.riley@uhhs.com
authors.forename: D E
authors.initials: DE
authors.lastname: Riley
authors.forename: T C
authors.initials: TC
authors.lastname: Chelimsky
mesh_terms: D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003937:Diagnosis, Differential; D003943:Diagnostic Techniques, Neurological; D005260:Female; D006801:Humans; D008297:Male; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D018579:Patient Selection; D011237:Predictive Value of Tests