[Effect of MPA and MPA + TU on the rat spermatogenesis and sexual hormones].
OBJECTIVE
To investigate the effect of administration of MPA with/without TU on serum sexual hormones and spermatogenesis of male rats.


METHODS
Twenty rats had been classified into four groups. Each group received injection of saline(group A) or MPA(37.5 or 75 mg/kg) (group B or group C, respectively) or MPA (75 mg/kg) + TU (25 mg/kg) (group D) every month during three months. Data from serum sexual hormones (FSH, LH, T), sperm counting and motility had been collected and analysed.


RESULTS
Spermatogenesis of rats undergoing administration of MPA with or without TU had been suppressed. Serum FSH and LH of group B, C, D declined, and so did serum T of group D. Testis of rats of group D atrophied and sperm counting of group D decreased remarkably compared with group B and C. But there was no statistics difference of the sexual hormone level among group B, C and D.


CONCLUSIONS
Administration of MPA alone could suppress the levels of FSH and LH and block the spermatogenesis of male rats. MPA combined with TU could offer stronger suppression on spermatogenesis. Mechanism of the suppression on spermatogenesis of MPA + TU is not only limited in the feed-back of gonadotropin, but there maybe exist a direct suppression on testis.
Jia
Yue
Y
Research Center of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Cui
Yu-Gui
YG
Wang
Xing-Hai
XH
Tong
Jian-Sun
JS
Ma
Ding-Zhi
DZ
Cai
Rui-Fen
RF
Di
Fu-Song
FS
Sha
Jia-Hao
JH
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017258:Medroxyprogesterone Acetate; C010792:testosterone undecanoate