Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma.
To clarify the roles of p27 and c-myc in nasopharyngeal carcinoma (NPC), we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC. The results show that a low level of expression was observed in 47 and 41 cases, respectively. A low level of p27 expression was significantly correlated with loco-regional recurrence, and reduction in the c-myc protein was also correlated with neck metastasis in NPC. Our study indicates that a reduction in p27 expression is frequently seen in NPC. Furthermore, low expression levels of p27 and c-myc may contribute to the aggressive behavior of NPC.
Hwang
Chung-Feng
CF
Departments of Otolaryngology, Chang-Gung University, Chang-Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. cfhwang@seed.net.tw
Su
Chih-Ying
CY
Huang
Shung-Chen
SC
Huang
Chao-Cheng
CC
Fang
Fu-Min
FM
Lui
Chun-Chung
CC
Chang
Hsueh-Wen
HW
Cho
Chung-Lung
CL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D006258:Head and Neck Neoplasms / Q000556:secondary; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000172:deficiency / Q000502:physiology*; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D016271:Proto-Oncogene Proteins c-myc; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27