Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear.
Differential display analysis of differential mRNA expression in the rat inner ear under hypergravity identified two down- and four up-regulated genes. The up-regulation of microtubule associated protein 1A (MAP1A) in one of these was confirmed by real-time polymerase chain reaction. Since MAP1A is believed to work as a cell stabilizer connecting the actin with microtubule, this is possibly a response to strengthen this stabilizer under hypergravity. The MAP1A gene is the first found to be affected by gravity change in the inner ear.
Takumi
Yutaka
Y
Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Iijima
Naoya
N
Suzuki
Nobuyoshi
N
Oguchi
Tomohiro
T
Ando
Nagisa
N
Hashimoto
Makoto
M
Hara
Hirotaka
H
Yamashita
Hiroshi
H
Usami
Shin-ichi
S
D000818:Animals; D001483:Base Sequence; D007758:Ear, Inner / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D018471:Hypergravity; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation / Q000502:physiology*
C093429:MAP1A protein, human; C490546:Map1a protein, rat; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger