title: [Antigen transporter gene polymorphism and predisposition to Graves disease: a preliminary analysis].
abstract: OBJECTIVE
  To examine the distribution of transporter associated with antigen processing (TAP) gene polymorphism in a southern Chinese population and the association between TAP gene polymorphism and predisposition to Graves disease.
  
  
  METHODS
  We have performed TAP genotyping in 67 Graves disease patients and 69 healthy controls by amplification refractory mutation system (ARMS).
  
  
  RESULTS
  Distribution of TAP genes in our healthy controls shows similar but some different findings as compared with studies in other countries and other regions of our country, suggesting that the distribution of TAP genes might have ethnic or regional differences. The frequency of TAP1D haplotypes was significantly higher in the healthy controls than in the Graves disease patients (RR = 0.17, P < 0.01), and the frequency of TAP1C haplotypes was significantly lower in the healthy controls than in the Graves disease patients (RR = 2.05, P < 0.05). The frequency of TAP2A haplotypes was significantly higher in the healthy controls than in the Graves disease patients (RR = 0.46, P < 0.05), and the frequency of TAP2F haplotypes was significantly lower in the healthy controls than in the Graves disease patients (RR = 9.95, P < 0.05).
  
  
  CONCLUSIONS
  TAP1D and TAP2A haplotypes might confer protection against Graves disease while TAP1C and TAP2F haplotypes might confer cause susceptibility to Graves disease.
authors.affiliation: Endocrinology Department of Internal Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China. cmy1976@21cn.com
authors.forename: Mengyin
authors.initials: M
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Hua
authors.initials: H
authors.lastname: Cheng
authors.forename: Helin
authors.initials: H
authors.lastname: Ding
authors.forename: Zuzhi
authors.initials: Z
authors.lastname: Fu
mesh_terms: D004198:Disease Susceptibility; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic