title: Protection against UVB irradiation by natural filters extracted from lichens.
abstract: Natural substances extracted from lichens and boldo tree were tested in vivo and in vitro as possible UV-light filters. The protection factors were compared with that found for the references: Nivea sun Spray LSF 5, octylmethoxycinnamate (OMC) and 4-tert.-butyl-4'-methoxy dibenzoylmethane (BM-DBM). The stability of the single compounds was studied through UV-Vis spectroscopy. Usnic acid resulted to be the best UVB filter, with an in vivo protection factor similar to Nivea sun Spray LSF 5. Most of the single compounds studied in vitro resulted to have higher or similar filtering power than octylmethoxycinnamate. The protection factors as well as the good UV-light absorption of their photo-products suggest that these natural substances may be useful as new filters in sun-screen preparations.
authors.affiliation: Department of Dermatology, Humboldt University (Charité), 10117 Berlin, Germany.
authors.forename: Fiorenza
authors.initials: F
authors.lastname: Rancan
authors.forename: Stefania
authors.initials: S
authors.lastname: Rosan
authors.forename: Kirsten
authors.initials: K
authors.lastname: Boehm
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fernández
authors.forename: M Eliana
authors.initials: ME
authors.lastname: Hidalgo
authors.forename: Wanda
authors.initials: W
authors.lastname: Quihot
authors.forename: Cecilia
authors.initials: C
authors.lastname: Rubio
authors.forename: Fritz
authors.initials: F
authors.lastname: Boehm
authors.forename: Helmut
authors.initials: H
authors.lastname: Piazena
authors.forename: Ute
authors.initials: U
authors.lastname: Oltmanns
mesh_terms: D001060:Aporphines / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D019169:Jurkat Cells; D008011:Lichens / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D013473:Sunscreening Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D001060:Aporphines; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D013473:Sunscreening Agents; C011686:boldine