Estrogenic effects from household stoves.
With the application of a genetically modified yeast, estrogen receptor-activating compounds were detected in the soot and emission gas of a wood-burning household stove. The EC50 value of 17beta-estradiol was divided by the EC50 value of soot, and the obtained relative estrogenic value for raw soot was 2.37E-5, indicating that soot was about 100,000 times less estrogenic than 17beta-estradiol. Chemical analysis revealed that alkyl phenol, benzonic acid, and PAHs represented the major constituents in the most potent fractions of the soot. Along with PAHs, other constituents might also contribute to the estrogenicity of soot.
Wu
W Z
WZ
State Key Laboratory for Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, PR China. wuwz@ihb.ac.cn
Chen
J
J
Rehmann
K
K
Schramm
K W
KW
Kettrup
D019817:Benzoic Acid / Q000009:adverse effects*; D001681:Biological Assay; D002244:Carbon / Q000009:adverse effects* / Q000737:chemistry*; D004958:Estradiol / Q000494:pharmacology; D010636:Phenols / Q000009:adverse effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects*; D011960:Receptors, Estrogen / Q000187:drug effects; D012016:Reference Values; D015003:Yeasts
D010636:Phenols; D011084:Polycyclic Aromatic Hydrocarbons; D011960:Receptors, Estrogen; D004958:Estradiol; D002244:Carbon; D019817:Benzoic Acid