title: Development of an injection molded poly(epsilon-caprolactone) intravaginal insert for the delivery of progesterone to cattle.
abstract: This paper reports experiments conducted to research, develop and clinically evaluate an injection molded intravaginal insert manufactured from the biodegradable polyester poly(epsilon-caprolactone). The study demonstrated that it is possible to engineer poly(epsilon-caprolactone) into a shape that is well retained, and can be used as a platform for the controlled delivery of progesterone via the vagina of cows. Field evaluation showed that the poly(epsilon-caprolactone) intravaginal inserts containing 10% (w/w) progesterone were at least as effective clinically as the commercially available CIDR intravaginal insert.
authors.affiliation: InterAg, 558 Te Rapa Road, PO Box 20055, Hamilton, New Zealand. mjr@interag l.co.nz
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rathbone
authors.forename: Craig R
authors.initials: CR
authors.lastname: Bunt
authors.forename: Colin R
authors.initials: CR
authors.lastname: Ogle
authors.forename: Shane
authors.initials: S
authors.lastname: Burggraaf
authors.forename: Keith L
authors.initials: KL
authors.lastname: Macmillan
authors.forename: Kim
authors.initials: K
authors.lastname: Pickering
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005260:Female; D011091:Polyesters / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D011374:Progesterone