title: [A case of metastatic breast cancer responding to weekly paclitaxel and high-dose toremifene administrated alternately].
abstract: A 64-year-old woman underwent muscle-preserving mastectomy for breast cancer in April 1999. She developed multiple lung metastases 3 months later. The metastases partially responded to 10 cycles of CAF (cyclophosphamide, adriamycin, 5-fluorouracil). However, her lung metastases worsened again 7 months later and CAF was not effective (progressive disease). We therefore began administration of low-dose paclitaxel (80 mg/m2/week) and high-dose toremifene (120 mg/day) alternately in April 2001. This alternative therapy brought a marked decrease in the lung metastases. After 4 cycles of this treatment, lung metastatic findings had disappeared from her chest X-ray. This alternative therapy is potentially effective against metastatic breast cancer.
authors.affiliation: Dept. of Surgery, Kainan Hospital.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Murakami
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Noda
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Okamura
authors.forename: Takumi
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Tadao
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Toyohisa
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Akio
authors.initials: A
authors.lastname: Harada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction; D017312:Toremifene / Q000008:administration & dosage
chemical_list: D017312:Toremifene; D017239:Paclitaxel