title: Impact of supplementary high calcium milk with additional magnesium on parathyroid hormone and biochemical markers of bone turnover in postmenopausal women.
abstract: The aim of this study was to investigate the impact of magnesium-enriched, high-calcium milk on serum parathyroid hormone (PTH) and biochemical markers of bone turnover in postmenopausal women. We recruited 50 healthy postmenopausal women to take part in this randomised controlled study. Half of the women consumed two serves of high-calcium skim milk enriched with magnesium (milk group) and half consumed two serves apple drink per day (apple group), each for 4 weeks. The milk provided 1200 mg calcium and an additional 106 mg magnesium. We investigated the responses of serum PTH, as well as the serum and urinary calcium, magnesium and biochemical markers of bone turnover. There was no effect of time or drink on the clinical biochemistry, serum PTH or urine markers of bone resorption (free deoxypyridinoline and N-telopeptides). Serum C-telopeptides (CTX), another marker of bone resorption, did not change with time in the apple group. However, in the milk group, serum CTX deceased significantly from 0.43 +/- 0.04 ng/mL to 0.32 +/- 0.02 at 2 weeks (p < 0.0001) and 0.28 +/- 0.02 at 4 weeks (p < 0.0001). In the milk group, urinary calcium and magnesium each increased during the night but not during the day. Overall, these data suggest that milk has an antiresorptive effect on bone, but that this is not accompanied by measurable changes in serum PTH.
authors.affiliation: Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand. hilary.green@rdls.nestle.com
authors.forename: J Hilary
authors.initials: JH
authors.lastname: Green
authors.forename: Chris
authors.initials: C
authors.lastname: Booth
authors.forename: Richard
authors.initials: R
authors.lastname: Bunning
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001862:Bone Resorption / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D002940:Circadian Rhythm; D003094:Collagen / Q000097:blood / Q000187:drug effects / Q000652:urine; D024042:Collagen Type I; D005260:Female; D005527:Food, Fortified; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D008892:Milk / Q000737:chemistry; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control*; D010281:Parathyroid Hormone / Q000097:blood*; D010455:Peptides / Q000097:blood / Q000187:drug effects / Q000652:urine; D017698:Postmenopause
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D002136:Calcium, Dietary; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C036020:deoxypyridinoline; D003094:Collagen; D008274:Magnesium