title: Plasmacytoid dendritic cells: do they have a role in immune responses after hematopoietic cell transplantation?
abstract: Dendritic cells (DC) are the most potent antigen-presenting cells (APC) and are able to modulate immune responses. Investigators are studying methods to exploit the immunogenic and tolerogenic properties of DC. In the context of hematopoietic cell transplantation, DC might be helpful to facilitate engraftment and prevent graft-versus-host disease (GVHD) reactions. In this paper, we review circumstantial evidence that immature plasmacytoid DC might affect immune responses after transplantation of hematopoietic cells from allogeneic donors.
authors.affiliation: Division of Clinical Research, Fred Hutchinson Cancer Research Center, Department of Medicine, Division of Oncology, University of Washington, Seattle, Washington, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Rossi
authors.forename: Mario
authors.initials: M
authors.lastname: Arpinati
authors.forename: Damiano
authors.initials: D
authors.lastname: Rondelli
authors.forename: Claudio
authors.initials: C
authors.lastname: Anasetti
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology*; D006801:Humans; D033581:Stem Cell Transplantation / Q000009:adverse effects*