title: Monoclonal antibody manufacturing in transgenic plants--myths and realities.
abstract: The number and types of antibodies expressed in plants has increased steadily since the first reports of this accomplishment in the 1980s, illustrating the versatility of plants as a production system for antibodies. Many recent reviews have detailed the antibody forms that have been derived from plant expression systems. This contribution focuses on the remaining challenges to develop plant-derived therapeutic antibodies into products, and some of the progress that is being made in addressing these challenges.
authors.affiliation: ProdiGene, Inc., 101 Gateway Blvd, Suite 100, College Station, Texas 77845, USA. eha105@aol.com
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Hood
authors.forename: Susan L
authors.initials: SL
authors.lastname: Woodard
authors.forename: Michael E
authors.initials: ME
authors.lastname: Horn
mesh_terms: D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000191:economics; D004345:Drug Industry / Q000191:economics / Q000379:methods; D018506:Gene Expression Regulation, Plant; D006019:Glycolysis / Q000235:genetics; D030821:Plants, Genetically Modified / Q000276:immunology / Q000378:metabolism*; D012639:Seeds / Q000235:genetics* / Q000378:metabolism*; D014342:Truth Disclosure; D003313:Zea mays / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal