Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement.
Ben-Shabat
Shimon
S
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Itagaki
Yasuhiro
Y
Jockusch
Steffen
S
Sparrow
Janet R
JR
Turro
Nicholas J
NJ
Nakanishi
Koji
K
D000475:Alkenes / Q000737:chemistry; D000818:Animals; D004852:Epoxy Compounds; D005027:Ethylene Oxide / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D008027:Light; D008062:Lipofuscin / Q000737:chemistry; D008268:Macular Degeneration / Q000209:etiology; D010777:Photochemistry; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents; D012176:Retinoids / Q000737:chemistry* / Q000528:radiation effects; D026082:Singlet Oxygen
C112040:A2-E (N-retinylidene-N-retinylethanolamine); D000475:Alkenes; D004852:Epoxy Compounds; D008062:Lipofuscin; D011726:Pyridinium Compounds; D011838:Radiation-Sensitizing Agents; D012176:Retinoids; C475815:nonaoxirane; D026082:Singlet Oxygen; D005027:Ethylene Oxide