Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.
Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5.
Lim
Hyun Suk
HS
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Oh
Yong Seok
YS
Suh
Pann Ghill
PG
Chung
Sung Kee
SK
D000818:Animals; D016466:CHO Cells; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006224:Cricetinae; D017874:Immediate-Early Proteins / Q000037:antagonists & inhibitors*; D007202:Indicators and Reagents; D008246:Lysophospholipids; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D017874:Immediate-Early Proteins; D007202:Indicators and Reagents; D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine