title: High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation.
abstract: t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.
authors.affiliation: Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan.
authors.forename: Shih-Sung
authors.initials: SS
authors.lastname: Chuang
authors.forename: Chuan
authors.initials: C
authors.lastname: Lee
authors.forename: Rifat A
authors.initials: RA
authors.lastname: Hamoudi
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Liu
authors.forename: Po-Shing
authors.initials: PS
authors.lastname: Lee
authors.forename: Hongtao
authors.initials: H
authors.lastname: Ye
authors.forename: Tim C
authors.initials: TC
authors.lastname: Diss
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dogan
authors.forename: Peter G
authors.initials: PG
authors.lastname: Isaacson
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013624:Taiwan; D014178:Translocation, Genetic