title: Anti-saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: potential clinical value.
abstract: Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described as specific markers in Crohn's disease and their healthy first-degree relatives. 171 patients with Crohn's disease, their 105 first-degree relatives, 145 patients with ulcerative colitis and 101 first-degree relatives of patients with ulcerative colitis, 50 patients with infectious enterocolitis and 100 healthy controls were tested for ASCA employing the ELISA technique. When compared with the healthy controls (p < 0.0001) and patients with infectious enterocolitis (p < 0.0001) the prevalence of ASCA was significantly increased in patients with Crohn's disease and their first-degree relatives (p < 0.01). Further significant differences concerning the frequency of ASCA within the different groups of our study population were not observed. In particular, ASCA were not found in increased prevalence in infectious enterocolitis. These observations are compatible with a role of ASCA as a marker of genetic predisposition to Crohn's disease.
authors.affiliation: Medizinische Klinik, Standort Innenstadt der Ludwig-Maximilians-Universität München, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Glas
authors.forename: H-P
authors.initials: HP
authors.lastname: Török
authors.forename: F
authors.initials: F
authors.lastname: Vilsmaier
authors.forename: K-H
authors.initials: KH
authors.lastname: Herbinger
authors.forename: M
authors.initials: M
authors.lastname: Hoelscher
authors.forename: C
authors.initials: C
authors.lastname: Folwaczny
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology*; D008297:Male; D012441:Saccharomyces cerevisiae / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A; D007074:Immunoglobulin G