title: Analytical techniques for small molecule solid phase synthesis.
abstract: Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthesis either by monitoring the resin-bound species directly or by the analysis of small quantities of material cleaved from the support. This review outlines some of the principles of the various techniques for the analysis of intermediates and products obtained from solid-phase chemistry.
authors.affiliation: ChemCodes Inc., 2300 Englert Drive, Durham, NC 27713, USA. jan_scicinski@chemcodes.com
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Scicinski
authors.forename: Miles S
authors.initials: MS
authors.lastname: Congreveb
authors.forename: Corinne
authors.initials: C
authors.lastname: Kay
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009930:Organic Chemicals / Q000032:analysis* / Q000138:chemical synthesis; D012117:Resins, Synthetic; D013055:Spectrophotometry, Infrared
chemical_list: D009930:Organic Chemicals; D012117:Resins, Synthetic