title: Differential growth of goldfish retinal explants on regenerating and non-regenerating optic tract membranes.
abstract: Regenerating goldfish retinal explants were cultured on poly-L-lysine (control) or poly-L-lysine overlaid with membranes isolated from non-regenerating optic tract (OTr) and 10- or 21-day regenerating OTr. Non-regenerating OTr substrate inhibited all neurite growth while 10- and 21-day regenerating OTr substrates significantly increased the average neurite number per explant and average neurite length compared to controls. These results indicate an upregulation of neurite growth permissive properties of regenerating OTr membranes.
authors.affiliation: Neuroscience Program, Department of Biological Science, Florida State University, Biology Unit I, Rm 212, Tallahassee, FL 32306, USA.
authors.forename: Yung Kang
authors.initials: YK
authors.lastname: Su
authors.forename: John S
authors.initials: JS
authors.lastname: Elam
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D003463:Cues; D006054:Goldfish / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure*; D006133:Growth Substances / Q000378:metabolism; D023421:Models, Animal; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D012160:Retina / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000166:cytology* / Q000378:metabolism; D014795:Visual Pathways / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
chemical_list: D006133:Growth Substances