2,5-hexanedione-induced testicular injury.
Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.
Boekelheide
Kim
K
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA. Kim_Boekelheide@Brown.edu
Fleming
Shawna L
SL
Allio
Theresa
T
Embree-Ku
Michelle E
ME
Hall
Susan J
SJ
Johnson
Kamin J
KJ
Kwon
Eun Ji
EJ
Patel
Sutchin R
SR
Rasoulpour
Reza J
RJ
Schoenfeld
Heidi A
HA
Thompson
Stephanie
S
D000818:Animals; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004195:Disease Models, Animal; D004785:Environmental Pollutants / Q000633:toxicity*; D006588:Hexanones / Q000633:toxicity*; D006801:Humans; D008297:Male; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D003432:Cross-Linking Reagents; D004785:Environmental Pollutants; D006588:Hexanones; C011269:2,5-hexanedione