title: Nuclear structure and intranuclear retention of premature RNAs.
abstract: Eukaryotic cells are highly compartmentalized, each compartment being surrounded by a lipid bilayer. This membrane-based organization allows cells to use their volumes to encode information. The lack of intranuclear membranes suggested that the nucleus was largely devoid of structural organization. However, recent work has defined numerous specialized nuclear subdomains. Importantly, RNA processing factors do not display random distribution but cluster in defined nuclear bodies. Although these structures are well characterized morphologically, their function in relation to RNA metabolism remains elusive. In this review, we will discuss the putative participation of nuclear substructures in a quality control step of RNA biogenesis, the nuclear retention of premature RNA.
authors.affiliation: Unité de Biologie Cellulaire du Noyau, Institut Pasteur, 25 rue du Docteur Roux, Paris cedex, France. ogadal@pasteur.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Gadal
authors.forename: Ulf
authors.initials: U
authors.lastname: Nehrbass
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D012313:RNA / Q000096:biosynthesis* / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D012313:RNA