title: Cytotoxic triterpenes from the twigs of Celtis philippinensis.
abstract: Two triterpene esters, 3beta-trans-sinapoyloxylup-20(29)-en-28-ol (1) and 3beta-trans-feruloyloxy-16 beta-hydroxylup-20(29)-ene (2), were isolated as cytotoxic constituents from the chloroform-soluble extract of the twigs of Celtis philippinensis, along with five known triterpenes, 3beta-O-(E)-feruloylbetulin (3), 3beta-O-(E)-coumaroylbetulin (4), betulin (5), 20-epibryonolic acid (6), and ursolic acid (7). The structures of 1 and 2 were assigned from their 1D and 2D NMR spectroscopic data. All isolates were evaluated for cytotoxicity against several human cancer cell lines.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D018520:Plant Shoots / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D034401:Ulmaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes