Aziridines and aziridinium ions in the practical synthesis of pharmaceutical intermediates--a perspective.
Recent methods for the synthesis of aziridines and aziridinium ions, the mechanisms of their nucleophilic ring-opening reactions and applications to the practical synthesis of pharmaceutical intermediates are reviewed.
Dahanukar
Vilas H
VH
Schering-Plough Research Institute, Department of Synthetic Chemistry, 1011 Morris Avenue, Mailstop U-3-2-2100, Union, NJ 07083, USA. vilas.dahanukar@spcorp.com
Zavialov
Ilia A
IA
D000818:Animals; D001388:Aziridines / Q000138:chemical synthesis* / Q000378:metabolism*; D006801:Humans; D007477:Ions; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000378:metabolism*; D013678:Technology, Pharmaceutical / Q000379:methods*
D001388:Aziridines; D007477:Ions; D004364:Pharmaceutical Preparations