[Investigation of the mechanism of genitofemoral nerve in the contralateral testes damage of unilateral cryptorchid rats].
OBJECTIVE
To investigate the mechanism of genitofemoral nerve in the contralateral testes damage of unilateral cryptorchid rats.


METHODS
After unilateral cryptorchid rat model (21-day) was made and the ipsilateral genitofemoral nerve was divided, the germ cells apoptosis and the concentrations of lactate of contralateral testes were detected and compared after 120 days.


RESULTS
After the ipsilateral genitofemoral nerve was divided, the germ cells apoptosis and the lactate levels of the contralateral testes were all decreased from (17.28 +/- 1.36)% to (5.76 +/- 0.76)% and (2.19 +/- 0.24) mmol/L to (1.70 +/- 0.31) mmol/L, respectively.


CONCLUSIONS
The damage pathway of the contralateral testes of unilateral cryptorchidism probably related to the apoptosis of the germ cells which caused by the reflex decrease of the contralateral testicular blood flow via the transmissions of genitofemoral nerve.
Zhu
Xin-Shen
XS
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Zheng
Xin-Min
XM
Li
Shi-Wen
SW
Zheng
Hang
H
Hu
Li-Quan
LQ
D000818:Animals; D017209:Apoptosis; D003456:Cryptorchidism / Q000473:pathology*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009929:Organ Size; D051381:Rats; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000098:blood supply / Q000294:innervation* / Q000473:pathology*
D019344:Lactic Acid