Beta-amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease.
In order to analyze the metabolic response of AD patient platelets to beta-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the beta-amyloid active fragment 25-35 (betaA(25-35)). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of beta-amyloid on AD neuronal cells.
Casoli
Tiziana
T
N. Masera INRCA Research Department, Neurobiology of Aging Center, Via Birarelli 8, 60121 Ancona, Italy. t.casoli@inrca.it
Di Stefano
Guiseppina
G
Delfino
Alessia
A
Solazzi
Moreno
M
Fattoretti
Patrizia
P
Bertoni-Freddari
Carlo
C
Guidi
Marco
M
Scarpino
Osvaldo
O
Giunta
Sergio
S
Galeazzi
Luciano
L
D000544:Alzheimer Disease / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D010446:Peptide Fragments / Q000633:toxicity*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)