title: Beta-amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease.
abstract: In order to analyze the metabolic response of AD patient platelets to beta-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the beta-amyloid active fragment 25-35 (betaA(25-35)). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of beta-amyloid on AD neuronal cells.
authors.affiliation: N. Masera INRCA Research Department, Neurobiology of Aging Center, Via Birarelli 8, 60121 Ancona, Italy. t.casoli@inrca.it
authors.forename: Tiziana
authors.initials: T
authors.lastname: Casoli
authors.forename: Guiseppina
authors.initials: G
authors.lastname: Di Stefano
authors.forename: Alessia
authors.initials: A
authors.lastname: Delfino
authors.forename: Moreno
authors.initials: M
authors.lastname: Solazzi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
authors.forename: Carlo
authors.initials: C
authors.lastname: Bertoni-Freddari
authors.forename: Marco
authors.initials: M
authors.lastname: Guidi
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Scarpino
authors.forename: Sergio
authors.initials: S
authors.lastname: Giunta
authors.forename: Luciano
authors.initials: L
authors.lastname: Galeazzi
mesh_terms: D000544:Alzheimer Disease / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D010446:Peptide Fragments / Q000633:toxicity*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)