[Interconnection between insulin resistance and lipid metabolism disorders in obese patients].
OBJECTIVE
Investigation of blood lipid spectrum, level of free fatty acids (FFA), glucose, insulin in blood and insulin resistance in obese patients depending on the type of obesity and effects on them of biguanides derivatives.


METHODS
Routine blood biochemical examination was made in 59 obese patients. 34 of them had trunk obesity (TO) and 25--gluteofemoral obesity (GFO). 18 patients with TO received gliformine treatment in a day dose 1.5 g for 3 months.


RESULTS
More pronounced metabolic disturbances indicated by the presence of insulin resistance, compensatory hyperinsulinemia, high levels of FFA associated with impaired glucose tolerance and dislipidemia, high rate of arterial hypertension were observed in patients with TO. Correlations were found between lipid metabolism disturbances and insulin resistance. Gliformin treatment resulted in loss of weight, decline of insulin resistance and hyperinsulinemia, improvement of carbohydrate metabolism, lipid blood spectrum, lowering of blood pressure.


CONCLUSIONS
Biguanide derivatives are a perspective group of drugs for treatment of the diseases running with insulin resistance.
Ageeva
V V
VV
Krasil'nikova
E I
EI
Zubina
I M
IM
Shliakhto
E V
EV
D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin