Optimal dose of risperidone and olanzapine for patients with schizophrenia in Taiwan.
Risperidone and olanzapine-administration data were collected for schizophrenia patients treated at four Taiwanese medical centres. Only stable patients maintained on a medication at a dose that had remained unchanged for more than 1 month were included in the analysis. Of the 268 cases, 175 were treated with risperidone and 93 with olanzapine at mean daily doses of 3.56 +/- 1.54 mg and 12.21 +/- 4.99 mg, respectively. The majority of the risperidone-treated patients (73.2%) received 2-4 mg per day, with another 19.0% receiving 5-6 mg. A daily dose of 10-20 mg was received by 82.9% of the olanzapine group. Although the mean daily doses for both drugs were slightly higher for inpatients than outpatients, statistical significance was not achieved. Further, no gender or age-group dose differences were demonstrated for either drug.
Liu
Chia-Yih
CY
Department of Psychiatry, Chang Gung Memorial Hospital, Linkou and Chang Gung University, Taoyuan, Taiwan. liucy752@cgmh.org.tw
Chiu
Nan-Ying
NY
Wu
Ching-Kuan
CK
Yuan
Lo-Ming
LM
Hsiao
Mei-Chun
MC
Liao
Oscar
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018967:Risperidone / Q000008:administration & dosage* / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy* / Q000208:ethnology; D013624:Taiwan / Q000208:ethnology; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D018967:Risperidone; D000077152:Olanzapine