title: The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences.
abstract: The endocytic system of kinetoplastid parasites is a highly polarized membrane network focused on the flagellar pocket localized at one end of the cell. When first characterized, the endosomal network was envisioned as a simple system for uptake of extracellular material by fluid-phase or receptor-mediated mechanisms. Subsequently, it has become clear that the kinetoplastid endosomal system has an active and vital role in avoiding the host immune system and virulence, as well as providing the basic functions to fulfil cellular nutritional requirements. In two reviews, recent advances in the definition and comprehension of kinetoplastida endocytosis are discussed and, in Trypanosoma brucei in particular as the more developed experimental system. In Part 1, the endocytic system is considered in context of the surface molecules and their potential roles in virulence.
authors.affiliation: Wellcome Trust Laboratories for Molecular Parasitology, Dept of Biological Sciences, Imperial College of Science, Technology and Medicine, Exhibition Road, London, UK.
authors.forename: Gareth W
authors.initials: GW
authors.lastname: Morgan
authors.forename: Belinda S
authors.initials: BS
authors.lastname: Hall
authors.forename: Paul W
authors.initials: PW
authors.lastname: Denny
authors.forename: Mark
authors.initials: M
authors.lastname: Carrington
authors.forename: Mark C
authors.initials: MC
authors.lastname: Field
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D005407:Flagella / Q000378:metabolism / Q000648:ultrastructure; D006790:Host-Parasite Interactions; D007891:Leishmania / Q000276:immunology / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000276:immunology / Q000378:metabolism*; D014774:Virulence / Q000502:physiology
chemical_list: D014643:Variant Surface Glycoproteins, Trypanosoma