title: The effects of exposure of 60Co on the oxidant/antioxidant status among radiation victims.
abstract: This retrospective study has been performed with radiation victims who were accidentally exposed to a 60Co source and its release into the environment. The aim of the study was to assess the effects of elevated radiation exposures on plasma level, on erythrocyte thio barbituric acid reactive substance (TBARS) level and on erythrocyte glutathione (GSH) levels. Patients were treated in different hospitals with different symptoms such as nausea, vomiting, dizziness, along with severe anemia in some patients. Blood samples were collected 3-5 days following the radiation accident. Increases in plasma (6.25 +/- 0.90 nmol ml(-1)) and erythrocyte TBARS levels (330.5 +/- 30.5 micromol gHb(-1)) were found in comparison to a healthy group (3.72 +/- 0.68 nmol ml(-1) and 150.7 +/- 20.5 micromol gHb(-1), respectively) at a significant level (p<0.001). Erythrocyte GSH levels (5.2 +/- 0.30 micromol gHb(-1)) were found to be decreased among the victims (healthy group: 10.2 +/- 0.7 micromol gHb(-1)) at the same significance level (p<0.001). These observations confirm a significant change induced by radiation in the oxidant/antioxidant status among the victims. It is suggested here that antioxidant supplementation therapy might be effective in preventing the harmful effects of 60Co radiation among radiation victims.
authors.affiliation: Department of Nuclear Medicine, Istanbul University, Istanbul, Turkey. mmdemir@e-kolay.net
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demir
authors.forename: Dildar
authors.initials: D
authors.lastname: Konukoğlu
authors.forename: Levent
authors.initials: L
authors.lastname: Kabasakal
authors.forename: Hakan Kadir
authors.initials: HK
authors.lastname: Yelke
authors.forename: Kadir
authors.initials: K
authors.lastname: Ergen
authors.forename: Sabbir
authors.initials: S
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D004912:Erythrocytes / Q000737:chemistry; D005978:Glutathione / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011832:Radiation Injuries / Q000503:physiopathology*; D018788:Radioactive Hazard Release; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*
chemical_list: D000975:Antioxidants; D003037:Cobalt Radioisotopes; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione