[Lipid metabolism and functional status of the kidney in hypothyroid patients depending on the phase of disease].
OBJECTIVE
To evaluate renal function in correlation with lipid metabolism parameters in patients with primary hypothyroidism (HT) in compensation and decompensation.


METHODS
45 HT patients' examination included study of blood creatinine, urea, cholesterol, triglycerides, high and low density lipoproteins, urinary microalbumin, thyroid hormones and thyrotropin, beta 2-microglobulin levels, glomerular filtration rate (GFR), renal functional reserve (RFR). Also, Zimnitsky test and ultrasound investigation of the kidneys were made.


RESULTS
It was found that renal dysfunction in decompensated HT is characterized by normal renal concentration function, high intraglomerular pressure (low GFR and RFR), high concentration of beta 2-microglobulin in blood. Severe HT runs with negative correlation between GFR and total blood cholesterol, LDL. Albuminuria and low RFR in decompensated HT and marked hyperlipidemia suggest development of glomerulopathy related to abnormal physicochemical processes in glomerular endothelium.


CONCLUSIONS
Patients with decompensated HT have apparant glomerular dysfunction and disturbances in lipid metabolism. Hyperlipidemia in HT is a factor of renal damage.
Nikolaeva
A V
AV
Pimenov
L T
LT
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood* / Q000145:classification; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000503:physiopathology* / Q000652:urine; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D014463:Ultrasonography
D013963:Thyroid Hormones; D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine