The core structure of TMC-95A is a promising lead for reversible proteasome inhibition.
Kaiser
Markus
M
AG Biorganische Chemie, Max-Planck Institut für Biochemie, Am Klopferspitz 18 A, 82152 Martinsried, Germany.
Groll
Michael
M
Renner
Christian
C
Huber
Robert
R
Moroder
Luis
L
D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex; D015003:Yeasts / Q000201:enzymology
D009097:Multienzyme Complexes; D010456:Peptides, Cyclic; D011480:Protease Inhibitors; C408291:TMC-95A; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex