Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
The gastric cytoprotective properties of natural honey (monofloral and polyfloral specimens) and of a glucose-fructose-sucrose-maltose mixture (GFSM) was evaluated in the rat using absolute ethanol, indomethacin and acidified acetylsalicylic acid (ASA-HCl) as necrotising agents. Prior gastric administration of honey (2.5 g/kg) to animals induced a net reduction of hemorrhagic lesions length of the mucosa. Protection of the stomach elicited by both types of honey and GFSM was almost total against ethanol-induced lesions. Similar results were also observed when using ASA-HCl except that the percent protection was 87%. The percent reduction of indomethacin-induced gastric lesions was variable according to the nature of the test solution: GFSM mixture (41.1%) < polyfloral honey (55.2%) < monofloral honey (64.0%). Perfusion of the stomach with isotonic honey resulted in (1) a 70% reduction of the area of the lesions caused by ethanol, (2) the failure to prevent the transmural potential difference fall induced by ethanol, (3) an increase of basal and histamine-stimulated acid secretion. These results suggest that sugar rich solutions (GFSM and honey) may prevent gastric damage by a mechanism involving the release of some protective agents.
Gharzouli
Kamel
K
kam_gharzouli@hotmail.com
Amira
Smain
S
Gharzouli
Akila
A
Khennouf
Seddik
S
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D002241:Carbohydrates / Q000008:administration & dosage*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005632:Fructose / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D006722:Honey; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D008320:Maltose / Q000008:administration & dosage; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000150:complications*; D013395:Sucrose / Q000008:administration & dosage
D002241:Carbohydrates; D005632:Fructose; D000431:Ethanol; D013395:Sucrose; D008320:Maltose; D005947:Glucose; D001241:Aspirin; D007213:Indomethacin