title: Antibiotic resistance of Neisseria gonorrhoeae in Spain: trends over the last two decades.
abstract: In vitro activities of six antimicrobial agents against 2966 strains of Neisseria gonorrhoeae, isolated in Spain between 1983 and 2001, were determined. The percentages of intermediately susceptible and resistant isolates to penicillin (MIC > or = 0.12 mg/L) and tetracycline (MIC > or = 0.5 mg/L) were very high over the period of study. Strains intermediately susceptible to cefoxitin were identified at a variable percentage during the study. All N. gonorrhoeae isolates were susceptible to spectinomycin and ceftriaxone. Recently, resistance to ciprofloxacin has emerged.
authors.affiliation: Laboratorio de Referencia de Neisserias, Servicio de Bacteriología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Arreaza
authors.forename: C
authors.initials: C
authors.lastname: Salcedo
authors.forename: B
authors.initials: B
authors.lastname: Alcalá
authors.forename: S
authors.initials: S
authors.lastname: Berrón
authors.forename: E
authors.initials: E
authors.lastname: Martín
authors.forename: J A
authors.initials: JA
authors.lastname: Vázquez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016009:Chi-Square Distribution; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D006069:Gonorrhea / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data / Q000639:trends; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology*; D013030:Spain / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents