title: [Effects of sedative odorant inhalation on patients with atopic dermatitis].
abstract: Atopic dermatitis (AD) has been clinically well-known to be frequently exacerbated by psychological and physiological stress. In this study, we examined effects of sedative odorant (modified valerian oil) inhalation on patients with AD. We investigated clinical scores, skin physiological parameters and psychological questionnaire (POMS) every 2 weeks. For first 2 weeks, we arranged non-inhalation period. Results for non-inhalation period were compared with these of 2- or 4-week inhalation. As results, sum of skin clinical scores significantly improved after odorant inhalation. Some patients improved for non-inhalation period, too. However, patients that had not improved for non-inhalation period significantly improved after odorant inhalation. Skin conductance and skin dryness/scaling score also improved after odorant inhalation without improving for non-inhalation period. Psychological parameter (POMS) also tended to improve after odorant inhalation. These results suggest that sedative odorants may be useful as a complementary therapy for AD through psychosomatic stress care.
authors.affiliation: Shiseido Life Science Research Center, Japn. takeshi.hariya@to.shiseido.co.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hariya
authors.forename: Yuusuke
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Michiko
authors.initials: M
authors.lastname: Aihara
authors.forename: Mamiko
authors.initials: M
authors.lastname: Ishiwa
authors.forename: Michio
authors.initials: M
authors.lastname: Shibata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Zenro
authors.initials: Z
authors.lastname: Ikezawa
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D003876:Dermatitis, Atopic / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D013315:Stress, Psychological / Q000503:physiopathology*; D014632:Valerian
chemical_list: D006993:Hypnotics and Sedatives