title: A long-term survival case of gastric cancer treated by continuous low-dosage 5-fluorouracil and cisplatin: a case report.
abstract: We have experienced a case of long-term survival after treatment with low dosage 5-fluorouracil (5-FU) and cisplatin (FP regimen). The patient was a 60-year-old man diagnosed as having advanced gastric cancer type 3 with numerous large lymph node metastases. After treatment with 2 courses of FP regimen, the primary tumor and para-aortic lymph nodes were decreased in size by 41% and 92%, respectively, and the serum level of alpha-fetoprotein was decreased to normal. We then recommended surgery, but the patient did not consent. Therefore, he was treated with a third course of FP regimen. He died at 3 years later. These results suggested that the FP regimen was an effective treatment for advanced gastric cancer which was difficult for curative resection because of the numerous large lymph node metastases.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Keishiro
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Kikuo
authors.initials: K
authors.lastname: Koufuji
authors.forename: Shojiro
authors.initials: S
authors.lastname: Yano
authors.forename: Naotaka
authors.initials: N
authors.lastname: Murakami
authors.forename: Motoshi
authors.initials: M
authors.lastname: Miyagi
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Koga
authors.forename: Jinryo
authors.initials: J
authors.lastname: Takeda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017741:Survivors; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin; D005472:Fluorouracil