Preparation and investigation of antibacterial carbohydrate-based surfaces.
Surfaces bearing carbohydrate units have been modified in a two-step process to incorporate functionalities (lipophilic with polycationic units) that bear antibacterial activity. The effectiveness of these modified surfaces for antibacterial action against a series of seven Gram-positive and Gram-negative bacteria are reported.
Abel
Tanya
T
Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, W-333, New York, NY 10038, USA.
Cohen
JaimeLee Iolani
JI
Engel
Robert
R
Filshtinskaya
Maya
M
Melkonian
Alice
A
Melkonian
Karin
K
D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D032561:Cotton Fiber; D003902:Detergents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D000644:Quaternary Ammonium Compounds; D013329:Structure-Activity Relationship; D013499:Surface Properties
D000891:Anti-Infective Agents, Local; D002241:Carbohydrates; D003902:Detergents; D004202:Disinfectants; D000644:Quaternary Ammonium Compounds