title: Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders.
abstract: Epstein-Barr virus (EBV) is associated with a still growing spectrum of clinical disorders, ranging from acute and chronic inflammatory diseases to lymphoid and epithelial malignancies. Based on a combination of in vitro and in vivo findings, EBV is thought to contribute in the pathogenesis of these diseases. The different EBV gene expression patterns in the various disorders, suggest different EBV-mediated pathogenic mechanisms. In the following pages, an overview of the biology of EBV-infection is given and functional aspects of EBV-proteins are discussed and their putative role in the various EBV-associated disorders is described. EBV gene expression patterns and possible pathogenic mechanisms are discussed. In addition, expression of the cellular genes upregulated by EBV in vitro is discussed, and a comparison with the in vivo situation is made.
authors.affiliation: Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. j.middeldorp@vumc.nl
authors.forename: Jaap M
authors.initials: JM
authors.lastname: Middeldorp
authors.forename: Antoinette A T P
authors.initials: AA
authors.lastname: Brink
authors.forename: Adriaan J C
authors.initials: AJ
authors.lastname: van den Brule
authors.forename: Chris J L M
authors.initials: CJ
authors.lastname: Meijer
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology*; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D014764:Viral Proteins / Q000502:physiology*
chemical_list: D014764:Viral Proteins