title: 1H-NMR assay of papaverine hydrochloride and formulations.
abstract: A precise and specific 1H-NMR method has been developed for the assay of papaverine hydrochloride (1) as a bulk drug, as well as in tablet and injection dosage forms. The assay depends upon the integration of the 12 protons of the four methoxy groups of 1 relative to that of the three methyl protons of acetanilide (internal standard). In addition to the accurate quantitative determination of 1, the method provides a specific means of identifying 1 as well as detecting other alkaloids or impurities.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Street, 11562 Cairo, Egypt. aboutabl@frcu.eun.eg
authors.forename: Elsayed A
authors.initials: EA
authors.lastname: Aboutabl
authors.forename: Aida A
authors.initials: AA
authors.lastname: Ei-Azzouny
authors.forename: Manal S
authors.initials: MS
authors.lastname: Afifi
mesh_terms: D000083:Acetanilides / Q000737:chemistry; D004304:Dosage Forms; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010207:Papaver / Q000737:chemistry; D010208:Papaverine / Q000737:chemistry*; D011522:Protons; D013607:Tablets / Q000737:chemistry
chemical_list: D000083:Acetanilides; D004304:Dosage Forms; D011522:Protons; D013607:Tablets; D010208:Papaverine