title: A population-based survey on gastrointestinal tract symptoms and Helicobacter pylori infection in children and adolescents.
abstract: BACKGROUND
  Helicobacter pylori infection is a frequent infection mainly acquired in childhood. Even if the infection is almost invariably associated with mild to severe gastro-duodenal lesions, no specific clinical picture has been identified. The aim of this study was to evaluate the presence of dyspeptic symptoms and their relationship with the presence of H. pylori infection in the first two decades of life.
  
  
  METHODS
  A school-population sample size of 808 subjects from 6- to 19-year-olds was investigated for the presence of gastrointestinal tract symptoms and evaluated by a 13C-urea breath test for H. pylori infection. The relationship between clinical findings and H. pylori infection was evaluated by chi2 statistic or Fisher's exact test, as appropriate.
  
  
  RESULTS
  Symptoms of dyspepsia were identified in 45% of subjects, while the picture of ulcer-like and dysmotility-like forms were present in 3-4%. H. pylori infection was demonstrated in 95 (11.8%) subjects, 49.5% of them without symptoms. Severe epigastric pain and ulcer-like dyspepsia were significantly associated with H. pylori infection, while recurrent abdominal pain or dysmotility-like dyspepsia were not.
  
  
  CONCLUSIONS
  Dyspeptic symptoms are frequent in children, and its association with H. pylori infection is more evident than with recurrent abdominal pain. The age at which the infection is acquired seems to be under 6 years of age.
authors.affiliation: Dipartimento di Pediatria, IRCCS Policlinico S. Matteo, Università di Pavia, Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: De Giacomo
authors.forename: Valeria
authors.initials: V
authors.lastname: Valdambrini
authors.forename: Francesca
authors.initials: F
authors.lastname: Lizzoli
authors.forename: Anna
authors.initials: A
authors.lastname: Gissi
authors.forename: Marina
authors.initials: M
authors.lastname: Palestra
authors.forename: Carmine
authors.initials: C
authors.lastname: Tinelli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zagari
authors.forename: Franco
authors.initials: F
authors.lastname: Bazzoli
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology; D000293:Adolescent; D017677:Age Distribution; D001944:Breath Tests; D002648:Child; D004415:Dyspepsia / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D006306:Health Surveys; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012008:Recurrence