title: Severe Legionella pneumophila pneumonia in a patient with iron overload.
abstract: Iron plays a crucial role in the energy metabolism of microorganisms. Humans have developed iron-withholding mechanisms as a form of non-specific immunity. We describe a patient with iron overload and severe Legionella pneumophila pneumonia. This report emphasizes the importance of early consideration of and appropriate therapy against Legionella for patients with iron overload who present with community-acquired pneumonia.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Hospital of St. Raphael, Yale University School of Medicine, New Haven, Connecticut 06511, USA. hvikram@srhs.org
authors.forename: Holenarasipur R
authors.initials: HR
authors.lastname: Vikram
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Bia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D019190:Iron Overload / Q000150:complications* / Q000175:diagnosis; D016952:Legionella pneumophila / Q000302:isolation & purification*; D007877:Legionnaires' Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology; D012121:Respiration, Artificial; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents