title: [A case of vulval extramammary Paget's disease associated with pancreatic cancer that was successfully treated with chemotherapy].
abstract: We report the case of an 84-year-old woman with vulval extramammary Paget's disease associated with pancreatic cancer who was successfully treated. At first, biweekly low-dose FP (cisplatin 10 mg/body, 5-fluorouracil 250 mg/body) was administered by intravenous infusion. Next, we attempted a regimen of gemcitabine (1,000 mg/body) was administered weekly by intravenous infusion. As a result, the size of the pruritic lesion of the vulva was reduced more than 50%, and the serum level of CA19-9 decreased clearly. These treatments would be a valid option in certain cases of pancreas cancer and extramammary Paget's disease.
authors.affiliation: Dept. of Surgery and Gastroenterology, Keiju Medical Center.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Onishi
authors.forename: Toru
authors.initials: T
authors.lastname: Kamata
authors.forename: Hironori
authors.initials: H
authors.lastname: Hayashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Go
authors.initials: G
authors.lastname: Minatoya
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Michiwa
authors.forename: Toshiya
authors.initials: T
authors.lastname: Takeda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kanno
authors.forename: Koei
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D010145:Paget Disease, Extramammary / Q000150:complications / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000188:drug therapy*; D014846:Vulvar Neoplasms / Q000150:complications / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D005472:Fluorouracil; D000093542:Gemcitabine