Prolactin signaling and Stat5: going their own separate ways?
Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR-/- and Stat5ab-/- mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab-/- transplants not apparent in the PrlR-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.
Brisken
Cathrin
C
Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland. Cathrin.Brisken@isrec.unil.ch
Ayyanan
Ayyakkannu
A
Doppler
Wolfgang
W
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000502:physiology*; D004967:Estrogens / Q000494:pharmacology; D053614:Janus Kinase 2; D008321:Mammary Glands, Animal / Q000166:cytology*; D051379:Mice; D018345:Mice, Knockout; D008894:Milk Proteins; D010641:Phenotype; D011374:Progesterone / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins; D011981:Receptors, Prolactin / Q000502:physiology*; D050799:STAT5 Transcription Factor; D015534:Trans-Activators / Q000502:physiology*
D004268:DNA-Binding Proteins; D004967:Estrogens; D008894:Milk Proteins; D011518:Proto-Oncogene Proteins; D011981:Receptors, Prolactin; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D011374:Progesterone; D011505:Protein-Tyrosine Kinases; C507926:Jak2 protein, mouse; D053614:Janus Kinase 2