title: Human embryonic stem cell lines: socio-legal concerns and therapeutic promise.
abstract: Stem cell lines would be very valuable for the repair of diseased or damaged organs. Stem cells derived from adult tissues raise few ethical problems, and would not be rejected if derived from the patient. They show considerable plasticity and might be appropriate for some clinical conditions, but they tend not to grow well in culture. Stem cells derived from the early human embryo proliferate indefinitely in culture and can give rise to many different tissues, but their derivation requires destruction of the embryo, which is not ethically acceptable in some countries. Other countries allow strictly regulated destructive research on human embryos, usually those that have been produced for infertile couples in infertility clinics. Embryos that are no longer required for the couple's own reproductive project could be donated for research rather than just discarded. Different approaches are being developed to avoid immunological rejection of embryonic stem cells used for therapy. Derivation of embryonic stem cell lines by somatic cell nuclear transfer ('cloning') from the patients themselves might be one possible approach, but is unlikely to be used in routine clinical practice if more cost-effective methods are available.
authors.affiliation: Wellcome Trust/Cancer Research UK Institute, Cambridge University, UK. a.mclaren@welc.cam.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: McLaren
mesh_terms: D002454:Cell Differentiation; D003001:Cloning, Molecular / Q000379:methods; D004622:Embryo, Mammalian; D006801:Humans; D033581:Stem Cell Transplantation / Q000941:ethics* / Q000331:legislation & jurisprudence*; D013234:Stem Cells / Q000166:cytology*