Kinesin motors and disease.
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.
Mandelkow
Eckhard
E
Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany. mand@mpasmb.desy.de
Mandelkow
Eva-Maria
EM
D000818:Animals; D001370:Axonal Transport; D001692:Biological Transport; D004194:Disease; D015195:Drug Design; D016547:Kinesins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000473:pathology / Q000502:physiology*
D020409:Molecular Motor Proteins; D016547:Kinesins