Antibacterial activity of a stearic acid derivative from Stemodia foliosa.
From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10 microg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.
Dantas da Silva
Lourinalda Luiza
LL
Departamento de Antibióticos - Centro de Ciências Biológicas, Universidade Federal de Pernambuco, PE, Brazil.
Nascimento
Márcia
M
Siqueira Silva
Dulce Helena
DH
Furlan
Maysa
M
da Silva Bolzani
Vanderlan
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D028083:Scrophulariaceae; D013228:Stearates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013229:Stearic Acids / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013228:Stearates; D013229:Stearic Acids; C472157:stearic acid 4-((n-pentoxy)phenethyl) ester; C031183:stearic acid; D017291:Clarithromycin