title: Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
abstract: Camptothecin consists of a lactone E ring adjacent to tetracyclic A-D rings of a planar chromophore, which are essential for topoisomerase I inhibition and DNA interaction. The A-D rings can be exploited to develop DNA-sequence-reading molecules. Indolizino[1,2-b]quinoline derivatives substituted with a piperidinoethyloxy side chain and an aminomethyl function on rings A and D, respectively, were synthesized, and their DNA binding and formaldehyde-mediated bonding properties were investigated.
authors.affiliation: Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille 2, BP 83, 59006 Lille, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Perzyna
authors.forename: Carine
authors.initials: C
authors.lastname: Marty
authors.forename: Michael
authors.initials: M
authors.lastname: Facompré
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Goossens
authors.forename: Nicole
authors.initials: N
authors.lastname: Pommery
authors.forename: Pierre
authors.initials: P
authors.lastname: Colson
authors.forename: Claude
authors.initials: C
authors.lastname: Houssier
authors.forename: Raymond
authors.initials: R
authors.lastname: Houssin
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hénichart
authors.forename: Christian
authors.initials: C
authors.lastname: Bailly
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D005557:Formaldehyde; D004247:DNA; D003850:Deoxyribonuclease I; D002166:Camptothecin