title: [Clinical investigation of 6 cases of urachal carcinoma].
abstract: We have encountered 6 cases of urachal carcinoma in the past 7 years. They consisted of 4 females and 2 males, with the mean age of 48 years old. Of them, 2 cases were identified as gestational complications. Bladder irritating symptoms and extracystic symptoms other than hematuria were not observed as initial symptoms, and urinary cytology was positive in 2 cases. Cystoscopy is essential for diagnosis, but the spread of the tumor was clearly visualized by sagittal section patterns on magnetic resonance imaging. A correlation between the tumor and clinical course was suggested immunohistochemically with, carcinoembronic antigen and carbohydrate antigen 19-9. Cases of gestation concurrent with urachal carcinoma are very rare, but are expected to increase in the future. Thus appropriate medical treatment must be given to the maternal body. For the treatment, appropriateness of advanced surgery more than partial resection of the bladder combined with total urachoumbilical resection was recommended. However, an effective adjuvant chemotherapy after the first surgical resection needs to be established to improve the patient's quality of life.
authors.affiliation: Department of Urology, Toho University School of Medicine, Ohashi Hospital.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Sawada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yabuki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Masuda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Satou
authors.forename: Kanami
authors.initials: K
authors.lastname: Kuroda
authors.forename: Masaharu
authors.initials: M
authors.lastname: Tajima
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Sawamura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsushima
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D003131:Combined Modality Therapy; D015653:Cystectomy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014497:Urachus
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen