The hitchhiker's guide to the nucleus.
The hormone-related protein PTHrP travels from the cytosol to the nucleus by binding to the transport factor importin . Remarkably, the site of recognition of PTHrP is the N-terminal half of importin , which also has Ran-binding and nucleoporin-binding capabilities and is, therefore, sufficient by itself to function in PTHrP nuclear import.
Conti
Elena
E
D021581:Active Transport, Cell Nucleus; D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D044162:Parathyroid Hormone-Related Protein / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D028961:beta Karyopherins / Q000737:chemistry / Q000378:metabolism
D044162:Parathyroid Hormone-Related Protein; D028961:beta Karyopherins