title: The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma in indomethacin-Induced apoptosis of colon cancer cells.
abstract: We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor kappaB (NF-kappaB) and peroxisome proliferator-activated receptor gamma (PPARgamma) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-kappaB suppression and PPARgamma activation.
authors.affiliation: Department of Internal Medicine and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Korea.
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Jin
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Kang
authors.forename: Sung Kwan
authors.initials: SK
authors.lastname: Shin
authors.forename: Kang Yell
authors.initials: KY
authors.lastname: Choi
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D016328:NF-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D020928:Mitogen-Activated Protein Kinases; D007213:Indomethacin