title: Translational control of gene expression and disease.
abstract: In the past decade, translational control has been shown to be crucial in the regulation of gene expression. Research in this field has progressed rapidly, revealing new control mechanisms and adding constantly to the list of translationally regulated genes. There is accumulating evidence that translational control plays a primary role in cell-cycle progression and cell differentiation, as well as in the induction of specific cellular functions. Recently, the aetiologies of several human diseases have been linked with mutations in genes of the translational control machinery, highlighting the significance of this regulatory mechanism. In addition, deregulation of translation is associated with a wide range of cancers. Current research focuses on novel therapeutic strategies that target translational control, a promising concept in the treatment of human diseases.
authors.affiliation: Max-Delbrück-Centre for Molecular Medicine, Robert Rössle Str. 10, 13092 Berlin, Germany. calkhov@mdc-berlin.de
authors.forename: Cornelis F
authors.initials: CF
authors.lastname: Calkhoven
authors.forename: Christine
authors.initials: C
authors.lastname: Müller
authors.forename: Achim
authors.initials: A
authors.lastname: Leutz
mesh_terms: D039642:Eukaryotic Initiation Factors / Q000235:genetics / Q000378:metabolism; D005600:Fragile X Syndrome / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D038621:Regulatory Sequences, Ribonucleic Acid / Q000235:genetics; D015398:Signal Transduction; D013922:Thrombocytosis / Q000235:genetics
chemical_list: D039642:Eukaryotic Initiation Factors; D038621:Regulatory Sequences, Ribonucleic Acid