title: Antiepiligrin cicatricial pemphigoid of the larynx successfully treated with a combination of tetracycline and niacinamide.
abstract: A case of antiepiligrin cicatricial pemphigoid that primarily involved the larynx and required a tracheostomy was studied. The diagnosis was based on the direct immunofluorescence findings of a biopsy specimen from the glottis, immunofluorescence using normal and 1M sodium chloride-split normal human skin as substrates, and immunoprecipitation. A dramatic clinical improvement was observed after the combined administration of tetracycline hydrochloride and niacinamide. The tracheal stoma could be shut after the narrow segment was cut by means of carbon dioxide laser therapy. The patient showed no respiratory difficulty during the 2-year follow-up period. The combined therapy of tetracycline and niacinamide is thus considered to be an effective treatment for various types of cicatricial pemphigoid.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kurume University School of Medicine, Asahi-machi 67, Kurume, 830-0011, Japan. orlkaku@med.kurume-u.ac.jp
authors.forename: Kikuo
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Mori
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kim B
authors.initials: KB
authors.lastname: Yancey
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015815:Cell Adhesion Molecules / Q000276:immunology; D004338:Drug Combinations; D006801:Humans; D007818:Laryngeal Diseases / Q000188:drug therapy* / Q000276:immunology; D007829:Laryngostenosis / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D008297:Male; D009536:Niacinamide / Q000627:therapeutic use*; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D013754:Tetracyclines; D014139:Tracheostomy; D000097794:Kalinin
chemical_list: D000900:Anti-Bacterial Agents; D015815:Cell Adhesion Molecules; D004338:Drug Combinations; D009536:Niacinamide; D013754:Tetracyclines; D000097794:Kalinin