[Chronic inflammatory polyradiculoneuritis and the axonal cytoskeleton: morphometric and immunocytochemical data].
We report morphometric and immunocytochemical data obtained from nervous biopsy in 7 patients with chronic inflammatory demyelinating neuropathy (CIDP), compared to 5 controls (without neurological involvement). Fiber loss was present in all cases and reached 50 p. 100 or more in 4 cases. The g myelination ratio was elevated in 3 cases only, indicating demyelination. The number of fibers labelled for the L subunit of neurofilaments was normal in cases with moderate fiber loss and dropped down for densities < 3900/mm2 (4 cases). Labelling with anti-GAP43 antibody was considerably increased in 3 cases, but did not correlate with fiber density or disease duration. These data confirm the importance of axonal lesions in CIDP and offer the opportunity to discuss their pathophysiological mechanisms.
Fressinaud
C
C
Département de Neurologie, UPRES EA 3143, C.H.U., F49033 Angers. Catherine.fressinaud@med.univ-angers.fr
Jean
I
I
D000368:Aged; D001369:Axons / Q000473:pathology*; D001706:Biopsy; D002452:Cell Count; D003599:Cytoskeleton / Q000473:pathology*; D005260:Female; D019922:GAP-43 Protein / Q000378:metabolism; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009138:Musculocutaneous Nerve / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology; D016707:Tissue Fixation
D019922:GAP-43 Protein