title: [The relationships of PSA, FPSAR, clinical and pathological stage in patients with prostate cancer].
abstract: OBJECTIVE
  To investigate the relationship between clinical and pathological stage, serum prostate specific antigen (PSA) concentration and free-to-total PSA ratio (FPSAR) in patients with prostate cancer.
  
  
  METHODS
  Clinical and pathological stage were determined on the basis of pathological examination and clinic material in 42 prostate cancer patients treated by prostatectomy. PSA and FPSAR were measured before the operation. Spearman rank correlation was applied to evaluate the relationship between clinical and pathological stage, serum PSA concentration and FPSAR.
  
  
  RESULTS
  Serum PSA concentration was significantly positively correlated with pathological stage(P < 0.05) but not correlated with clinical stage (P > 0.05) in prostate cancer patients. FPSAR was significantly correlated with pathological stage and negatively correlated with clinical stage in prostate cancer patients (P < 0.05).
  
  
  CONCLUSIONS
  FPSAR is a more powerful predictor of clinical stage, pathological stage and prognosis than PSA.
authors.affiliation: Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. liuhel@fmmu.edu.cn
authors.forename: He-Liang
authors.initials: HL
authors.lastname: Liu
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Yang
authors.forename: Bao-Qi
authors.initials: BQ
authors.lastname: Chen
authors.forename: Rong-Liang
authors.initials: RL
authors.lastname: Qin
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Shao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen