title: Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether-poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry.
abstract: The newly developed stable DMEPHF (1/15) complex was found to be a highly effective reagent for the cleavage of peptides from Merrifield resins; ease of handling and its simple, complete removal from the reaction mixture make the reagent system a very useful HF equivalent for applications in solid-phase peptide synthesis.
authors.affiliation: Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA.
authors.forename: Béla
authors.initials: B
authors.lastname: Török
authors.forename: Imre
authors.initials: I
authors.lastname: Bucsi
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
authors.forename: George A
authors.initials: GA
authors.lastname: Olah
mesh_terms: D020650:Combinatorial Chemistry Techniques; D005563:Formic Acid Esters; D006858:Hydrofluoric Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D006868:Hydrolysis; D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis*; D012117:Resins, Synthetic / Q000737:chemistry
chemical_list: D005563:Formic Acid Esters; D007202:Indicators and Reagents; D010455:Peptides; D012117:Resins, Synthetic; C476506:dimethyl ether-poly(hydrogen fluoride); C000345:t-butyloxycarbonyl group; D006858:Hydrofluoric Acid