Renal cell carcinoma with t(X;17): singular pediatric neoplasm with specific phenotype/genotype features.
Renal cell carcinomas in children are extremely rare and are usually associated with specific chromosomal rearrangements, different from those seen in adult patients. We present the case of a 9-year-old girl with a renal cell carcinoma with t(X;17) diagnosed at our institution. We also review the pertinent literature, with an emphasis on the genetic and molecular aspects associated with this rare neoplasm.
Zambrano
Eduardo
E
Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LB20, New Haven, CT 06520-8023, USA.
Reyes-Múgica
Miguel
M
D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002648:Child; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010641:Phenotype; D014178:Translocation, Genetic; D016896:Treatment Outcome
D014408:Biomarkers, Tumor