Hereditary chin trembling: a new family with exclusion of the chromosome 9q13-q21 Locus.
Hereditary chin trembling is a rare autosomal dominant condition that has been linked to chromosome 9q13-21 in one kindred. We describe a four-generation family with this condition and, using linkage analysis, have excluded the 9q13-21 region as causing the chin trembling in this family.
Grimes
David A
DA
Ottawa Health Research Institute, Ottawa, Canada. dagrimes@ottawahospital.on.ca
Han
Fabin
F
Bulman
Dennise
D
Nicolson
Mary Lou
ML
Suchowersky
Oksana
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage; D002680:Chin / Q000294:innervation*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014202:Tremor / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*
D019274:Botulinum Toxins, Type A