title: Ovarian hyperstimulation syndrome is associated with reversible impairment of vascular reactivity.
abstract: OBJECTIVE
  To determine if there is a loss of normal peripheral arteriolar vasoconstrictor reactivity in women with severe ovarian hyperstimulation syndrome (OHSS).
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  National University Hospital, Singapore.
  
  
  METHODS
  Forty-three women undergoing treatment in an IVF program: 22 women with severe OHSS and 21 normal women without OHSS.
  
  
  METHODS
  Measurement and quantification of the cutaneous arteriolar vasoconstrictor response using laser Doppler fluximetry.
  
  
  METHODS
  Changes in blood flow as an index of vasoconstrictor response before and after treatment for OHSS with albumin.
  
  
  RESULTS
  The mean (+/-SE) percentage (%) change in normal control women was -68.3% +/- 4.7. This was significantly different from women with OHSS (-32.3% +/- 11.1). The response in women with OHSS changed significantly after treatment with IV albumin (-60.4% +/- 5.7) and was no different than the control response. The reproducibility of the technique was -13.6% (+/-2.8).
  
  
  CONCLUSIONS
  Women with OHSS have impaired vascular reactivity when compared with normal women.
authors.affiliation: Department of Obstetrics and Gynecology, National University Hospital of Singapore, Singapore. obgflc@nus.edu.sg
authors.forename: Lian-Cheun
authors.initials: LC
authors.lastname: Foong
authors.forename: Balasubramanium
authors.initials: B
authors.lastname: Bhagavath
authors.forename: Jothi
authors.initials: J
authors.lastname: Kumar
authors.forename: Soon-Chye
authors.initials: SC
authors.lastname: Ng
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000503:physiopathology*; D011446:Prospective Studies; D012016:Reference Values; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply; D014666:Vasomotor System / Q000503:physiopathology*
chemical_list: D004958:Estradiol