title: Repeated access to sucrose augments dopamine turnover in the nucleus accumbens.
abstract: Dopamine in the nucleus accumbens has been implicated in motivated behavior, including feeding. Normal feeding occurs in patterns, but little is known about how these schedules influence this neural system. We hypothesized that repeated access to preferred foods would augment dopamine clearance. Rats on a restricted feeding schedule had access to 0.3 M sucrose or water followed 2 h later by chow. The rats were kept on this regimen for 7 days, with microdialysis performed on the last day. During the chow period, dopamine turnover in the nucleus accumbens was higher when preceded by sucrose than by water. This finding suggests that, under some dietary conditions, neuroadaptation occurs in response to feeding and these changes may, in turn, influence future meals.
authors.affiliation: Department of Behavioral Science, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA. axh40@psu.edu
authors.forename: Andras
authors.initials: A
authors.lastname: Hajnal
authors.forename: Ralph
authors.initials: R
authors.lastname: Norgren
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003463:Cues; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005508:Food Deprivation / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D017551:Microdialysis; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D013395:Sucrose; D004298:Dopamine