Modeling the spreading cortical depression wavefront.
Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2-5 mm/min and is followed by a 5-10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrated on a rat brain that had been segmented from a three-dimensional magnetic resonance image data set. With the help of this methodology it is possible to create specific patient models to better understand the mechanisms of SCD.
Baysal
Ugur
U
Hacettepe University, Department of Electrical and Electronics Engineering, Beytepe, Ankara, Turkey. ubaysal@hacettepe.edu.tr
Haueisen
Jens
J
D000818:Animals; D001921:Brain / Q000502:physiology; D013181:Cortical Spreading Depression / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007700:Kinetics; D008564:Membrane Potentials; D008959:Models, Neurological; D011817:Rabbits