title: [Localized invasive intracranial aspergillosis with multiple cranial nerve failure -- case report and review of the literature].
abstract: Contrary to the more frequent hematogenously spread cerebral aspergillosis, localized invasive intracranial aspergillosis is a fungal infection that can also occur in patients who are not severely immunosuppressed. This illness can be effectively treated in some of these patients by early and rigorous therapy. Localized invasion of the fungus, generally from one of the nasal sinuses, causes intracranial growth mainly along the base of the skull and larger vessels,where fibrous, granulomatous tissue develops. This generally leads to damage of the cranial nerves (primarily I-VI) as well as localized pain syndromes. We report on the clinical course documented by MRI of a patient with localized invasive intracranial aspergillosis who had multiple failure of cranial nerves following surgery for an aspergilloma of the maxillary sinus. Clinical course, imaging findings, and treatment of the illness are discussed with a review of the relevant literature.
authors.affiliation: Neurologische Klinik, Ludwig-Maximilians Universität,München.
authors.forename: F
authors.initials: F
authors.lastname: Winkler
authors.forename: K
authors.initials: K
authors.lastname: Seelos
authors.forename: J M
authors.initials: JM
authors.lastname: Hempel
authors.forename: H-W
authors.initials: HW
authors.lastname: Pfister
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000601:surgery; D003389:Cranial Nerve Diseases / Q000175:diagnosis* / Q000188:drug therapy; D003392:Cranial Sinuses / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008443:Maxillary Sinus / Q000601:surgery; D020953:Neuroaspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D009460:Neurologic Examination / Q000187:drug effects; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy; D019291:Skull Base / Q000473:pathology
chemical_list: D017964:Itraconazole; D000666:Amphotericin B