Apoptosis-independent functions of killer caspases.
Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.
Algeciras-Schimnich
Alicia
A
The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Barnhart
Bryan C
BC
Peter
Marcus E
ME
D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D002465:Cell Movement; D002470:Cell Survival; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism
D011956:Receptors, Cell Surface; D020169:Caspases