title: Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Brohm
authors.forename: Susanne
authors.initials: S
authors.lastname: Metzger
authors.forename: Ajay
authors.initials: A
authors.lastname: Bhargava
authors.forename: Oliver
authors.initials: O
authors.lastname: Müller
authors.forename: Folker
authors.initials: F
authors.lastname: Lieb
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000201:enzymology; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone