title: Serum cystatin C concentration as a marker of glomerular filtration rate in patients with various renal diseases.
abstract: OBJECTIVE
  The present study was undertaken to evaluate clinical application of serum cystatin C as a new marker of glomerular filtration rate (GFR) in patients with various renal diseases.
  
  
  METHODS
  A total of 140 patients were enrolled in the study. We measured the serum cystatin C levels and compared them with creatinine clearance (Ccr) and inulin clearance (Cin) as an indicator of GFR.
  
  
  RESULTS
  There was a significant positive correlation between serum cystatin C and creatinine levels (r=0.928). Serum cystatin C was inversely correlated with creatinine clearance. Moreover, the reciprocal serum cystatin C level was positively correlated with Cin (r=0.882). The receiver-operating characteristic curve of serum cystatin C and creatinine demonstrated that the diagnostic accuracy of the serum cystatin C level is superior to that of creatinine in identifying individuals with reduced GFR.
  
  
  CONCLUSIONS
  These results indicated that measurement of serum cystatin C is useful to estimate GFR, and in particular, to detect a mild reduction of GFR in patients with renal diseases.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Uchida
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Misao
authors.initials: M
authors.lastname: Tsukada
authors.forename: Shizue
authors.initials: S
authors.lastname: Sekine
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Itabashi
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nihei
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine