Drugs targeting functional bowel disorders: insights from animal studies.
Increased understanding of gastrointestinal pathophysiology in functional bowel disorders is leading to improved focus on relevant enteric, vagal and spinal afferent nervous systems, and targets operating on these systems. These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing factor and somatostatin.
Sanger
Gareth J
GJ
Neurology and Gastroenterology-CEDD, GlaxoSmithKline, Harlow, Essex, UK. Gareth_J_Sanger@gsk.com
Hicks
Gareth A
GA
D000818:Animals; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D010146:Pain / Q000188:drug therapy
D005765:Gastrointestinal Agents