title: Origin and filiation of human plasmacytoid dendritic cells.
abstract: Human plasmacytoid dendritic cells represent a rare population of leukocytes which produce high amounts of type I interferon in response to certain viruses. Although those cells were first described in 1958, there are still unsolved issues related to their origin and function. Recently, a leukemic counterpart of plasmacytoid dendritic cells was identified. Molecular approaches using either normal or leukemic plasmacytoid dendritic cells provide some new insights into the controversial lymphoid origin of those cells. The need for specific markers is still a critical aspect for the identification of plasmacytoid dendritic cells, whatever stage of differentiation, in normal as well as in pathological conditions. Hopefully, novel markers will allow delineation of the relationships between dendritic cells at different stages of differentiation/maturation along the myeloid and lymphoid lineages.
authors.affiliation: Laboratory for Immunological Research, Schering-Plough, Dardilly, France. francine.briere@spcorp.com
authors.forename: Francine
authors.initials: F
authors.lastname: Brière
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bendriss-Vermare
authors.forename: Thomas
authors.initials: T
authors.lastname: Delale
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Burg
authors.forename: Christophe
authors.initials: C
authors.lastname: Corbet
authors.forename: Marie Clotilde
authors.initials: MC
authors.lastname: Rissoan
authors.forename: Laurence
authors.initials: L
authors.lastname: Chaperot
authors.forename: Joël
authors.initials: J
authors.lastname: Plumas
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Jacob
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
authors.forename: Elizabeth E M
authors.initials: EE
authors.lastname: Bates
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D010950:Plasma Cells; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D015703:Antigens, CD; D007370:Interferon Type I