Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion.
Drosophila melanogaster has been introduced recently as a model organism in which to study the mechanisms by which drugs of abuse change behavior and by which the nervous system changes upon repeated drug exposure. Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels.
Rothenfluh
Adrian
A
Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143-0452, USA. adrianr@itsa.ucsf.edu
Heberlein
Ulrike
U
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm / Q000502:physiology; D003042:Cocaine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004331:Drosophila melanogaster; D004361:Drug Tolerance / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*
D000431:Ethanol; D000242:Cyclic AMP; D003042:Cocaine; D004298:Dopamine