Actin, microtubules and focal adhesion dynamics during cell migration.
Cell migration is a complex cellular behavior that results from the coordinated changes in the actin cytoskeleton and the controlled formation and dispersal of cell-substrate adhesion sites. While the actin cytoskeleton provides the driving force at the cell front, the microtubule network assumes a regulatory function in coordinating rear retraction. The polarity within migrating cells is further highlighted by the stationary behavior of focal adhesions in the front and their sliding in trailing ends. We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration.
Wehrle-Haller
Bernhard
B
Department of Pathology, Centre Médical Universitaire, 1 Rue Michel-Servet, 1211 4, Geneva, Switzerland. bernhard.wehrle-haller@medecine.unige.ch
Imhof
Beat A
BA
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D022001:Focal Adhesions / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000502:physiology*
D000199:Actins; D015815:Cell Adhesion Molecules