title: Treatment of intrabony periodontal defects with enamel matrix derivative: a literature review.
abstract: The enamel matrix derivative (EMD) has been recently introduced in the periodontal field to overcome short-comings associated with currently available regenerative techniques. Information accumulated over the past years with application of EMD guided regeneration (EGR) in intrabony periodontal defects allowed a thorough evidence-based retrospective analysis. Clinical data from EMD controlled studies were pooled for meta-analysis and weighted according to the number of treated defects. Clinical attachment gain amounted to 3.2 +/- 0.9 mm (33% of the original attachment level) and probing reduction averaged 4.0 +/- 0.9 mm (50% of the baseline probing depth) for a total of 317 lesions with a mean baseline depth of 5.4 +/- 0.8 mm. Improvements in clinical parameters achieved with EMD were statistically significant in reference to preoperative measurements. However, despite the overall efficacy of EGR therapy, a significant variation in clinical outcomes was observed. Similar therapeutic results were reported in studies where EGR was compared directly to guided tissue regeneration. However, the controlled clinical trials did not have adequate statistical power to firmly support superiority or equivalency between the 2 regenerative therapies. The statistical superiority of EGR over treatment with open flap debridement has been established. Preliminary histologic investigations with surgically created defects and experimental periodontal lesions demonstrated the ability of EGR to induce formation of acellular cementum and promote significant anaplasis of the supporting periodontal tissues. The potential of EMD to encourage periodontal regeneration was also confirmed in human intrabony defects. However, recent human histologic studies have questioned both the consistency of the histologic outcomes and the ability of EGR to predictably stimulate formation of acellular cementum. Identifying clinical modifying parameters and understanding cellular interactions are apparently essential for the development of methodologies to enhance predictability and extent of EGR clinical and histologic results.
authors.affiliation: Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, MA, USA. ckperio@otenet.gr
authors.forename: Christos D R
authors.initials: CD
authors.lastname: Kalpidis
authors.forename: Morris P
authors.initials: MP
authors.lastname: Ruben
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy*; D000818:Animals; D001861:Bone Regeneration; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D003739:Dental Cementum / Q000502:physiology; D003746:Dental Enamel Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D013552:Swine
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins