title: Serum soluble interleukin-2 receptor in eosinophilia.
abstract: The relationship between soluble interleukin-2 receptor (sIL-2R) levels and clinical characteristics was evaluated in patients with eosinophilia. Thirty-eight out of 60 patients showed sIL-2R levels of more than 800 U/ml. In these patients, sIL-2R was closely related to the eosinophil count, but not the IgE level. Their underlying diseases were heterogeneous, including neoplasms and collagen diseases. In patients with lower sIL-2R levels, there was no relationship to the eosinophil count, but sIL-2R was correlated with the IgE level. These findings indicate that patients with eosinophilia and higher sIL-2R levels tend to have underlying diseases other than allergy, and might be more severely ill than patients with lower sIL-2R levels. sIL-2R may be a good marker for evaluating patients with eosinophilia, as an indicator of the probable etiology and severity of their diseases.
authors.affiliation: Central Clinical Laboratory, Jikei University Hospital, Division of Hematology and Oncology, Jikei University School of Medicine, Tokyo, Japan. ken.kaito@jikei.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Kaito
authors.forename: Hiroko
authors.initials: H
authors.lastname: Otsubo
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ogasawara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kimura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kurihara
authors.forename: Masaru
authors.initials: M
authors.lastname: Koike
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Aiso
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003627:Data Interpretation, Statistical; D004802:Eosinophilia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012720:Severity of Illness Index; D012995:Solubility
chemical_list: D015415:Biomarkers; D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E