title: Characteristics and survival of patients with non-Hodgkin's lymphoma with and without acquired immunodeficiency syndrome.
abstract: Our objective was to determine the characteristics and survival of patients with non-Hodgkin's lymphoma (NHL) with and without acquired immunodeficiency syndrome (AIDS). A cancer registry and AIDS registry linkage for San Diego County was performed in October 1998 as part of a national multicentre study. We performed Kaplan-Meier analysis to compare survival in NHL patients with and without AIDS, after matching for age, sex, and race/ethnicity. We performed logistic regression to determine which patient and tumour characteristics were significantly associated with 1-year survival. Of the 4361 cases of NHL, 324 (7%) had AIDS and 4037 (93%) were not known to have AIDS. Patients with AIDS were more likely to have extranodal, high-grade, and disseminated NHL diagnosed by non-histologic means and were less likely to have received chemotherapy. Patients with AIDS and NHL who survived at least 1 year had less advanced disease stage and received chemotherapy. The median survival in patients with AIDS was 4 months (95% confidence interval (CI): 4-5) and 95 months (95% CI: 58-157) in patients without AIDS (P<0.001). Although these patients with AIDS-related NHL were unlikely to survive, the highly active antiretroviral agents currently used may improve outcomes in future patients.
authors.affiliation: Department of Medicine, Epidemiology Division, University of California, Irvine 92679, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Diamond
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Taylor
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality*; D000367:Age Factors; D002140:California; D002470:Cell Survival; D005260:Female; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000401:mortality*; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors