title: Oral dexketoprofen for pain treatment during diagnostic hysteroscopy in postmenopausal women.
abstract: OBJECTIVE
  To assess the efficacy of dexketoprofen (DEX) in reducing pain at different stages of the hysteroscopic procedure in comparison with local anaesthesia in menopausal women.
  
  
  METHODS
  Menopausal patients affected by uterine bleeding submitted to diagnostic hysteroscopy, were randomised to receive either 25 mg DEX tablet (n = 148) or intracervical injection of 5 ml mepivacaine 2% (n = 150). Pain suffered during the procedure itself and 30, 60, 120 min after, was scored on the 11 point Visual Analogic Scale, recorded and analysed.
  
  
  RESULTS
  No statistical difference were noted during the procedure itself in both groups of treatment. Patients treated with DEX has significantly less postoperative pain.
  
  
  CONCLUSIONS
  DEX is not superior to mepivacaine in reducing the discomfort of the procedure but does significantly reduce postoperative pain.
authors.affiliation: Department of Obstetric and Gynecology of the University Federico II of Naples, via Pansini 5, Napoli, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Mercorio
authors.forename: Raffaella
authors.initials: R
authors.lastname: De Simone
authors.forename: Paola
authors.initials: P
authors.lastname: Landi
authors.forename: Anna
authors.initials: A
authors.lastname: Sarchianaki
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tessitore
authors.forename: Carmine
authors.initials: C
authors.lastname: Nappi
mesh_terms: D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007267:Injections; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008619:Mepivacaine / Q000008:administration & dosage / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D017698:Postmenopause; D016896:Treatment Outcome; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; D008619:Mepivacaine; C118296:dexketoprofen trometamol