Polyamine involvement in breast cancer phenotype.
In this review, we will summarize current evidence implicating the polyamine pathway in two critical aspects of breast cancer biology, e.g. mammary carcinogenesis and tumor progression. We believe that the findings reported here provide a strong rationale for further exploring the role of anti-polyamine therapy in the adjuvant setting and in breast cancer chemoprevention.
Manni
Andrea
A
Division of Endocrinology, Department of Medicine, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D018890:Chemoprevention; D018450:Disease Progression; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism; D065108:Ornithine Decarboxylase Inhibitors; D010641:Phenotype; D011073:Polyamines / Q000378:metabolism*
D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines; D009955:Ornithine Decarboxylase