Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice.
BACKGROUND
As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice.


RESULTS
Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts.


CONCLUSIONS
The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
Hosseinzadeh
Hossein
H
Pharmaceutical Research Center and Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. hosseinzadehh@yahoo.com
Karimi
Gholam Reza
GR
Ameri
Maryam
M
D028524:Anethum graveolens / Q000737:chemistry*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005744:Gastric Acid / Q000378:metabolism; D006851:Hydrochloric Acid; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use; D012639:Seeds / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D006851:Hydrochloric Acid