Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa.
From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).
Ko
Jeong Suk
JS
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
Rho
Mun-Chual
MC
Chung
Mi Yeon
MY
Song
Hye Young
HY
Kang
Jong Seong
JS
Kim
Koanhoi
K
Lee
Hyun Sun
HS
Kim
Young Kook
YK
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D051048:Diacylglycerol O-Acyltransferase; D032086:Evodia; D005638:Fruit / Q000737:chemistry; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
C472153:1-methyl-2-(4,7-tridecadienyl)-4(1H)-quinolone; C472154:1-methyl-2-(6,9-pentadecadienyl)-4(1H)-quinolone; C472152:1-methyl-2-tetradecyl-4(1H)-quinolone; D000470:Alkaloids; D010936:Plant Extracts; D015363:Quinolones; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase