The orbitofrontal cortex in methamphetamine addiction: involvement in fear.
We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction.
Goldstein
Rita Z
RZ
Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA. rgoldstein@bnl.gov
Volkow
Nora D
ND
Chang
Linda
L
Wang
Gene-Jack
GJ
Fowler
Joanna S
JS
Depue
Richard A
RA
Gur
Ruben C
RC
D000328:Adult; D000367:Age Factors; D019969:Amphetamine-Related Disorders / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D016728:Self-Injurious Behavior / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D008694:Methamphetamine; D005947:Glucose