Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection.
CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans. In spite of the important role that CXCR4 plays in infection with feline immunodeficiency virus, expression on PBMC in vivo was unaffected by infection with either a primary or a cell culture-adapted virus strain.
Willett
Brian J
BJ
Retrovirus Research Laboratory, Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow, United Kingdom. b.willett@vet.gla.ac.uk
Cannon
Celia A
CA
Hosie
Margaret J
MJ
D000818:Animals; D001402:B-Lymphocytes / Q000737:chemistry; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000209:etiology*; D007963:Leukocytes, Mononuclear / Q000737:chemistry*; D009000:Monocytes / Q000737:chemistry; D019718:Receptors, CXCR4 / Q000097:blood* / Q000502:physiology; D013601:T-Lymphocytes / Q000737:chemistry
D019718:Receptors, CXCR4