title: Distribution of nociceptin-like immunoreactivity in the central nervous system of the Mongolian gerbil: an immunohistochemical study.
abstract: This study is designed to demonstrate the distribution of nociceptin, endogenous ORL1 receptor ligand, in the central nervous system of the Mongolian gerbil. To intensify the nociceptin-like immunoreactivity (NOC-LI), colchicine was administered into the lateral ventricle, at 48 h prior to the transcardiac perfusion. In the group without colchicine treatment, NOC-LI was observed in the fibres of the spinal dorsal horn, specifically in the superficial layers. However, the NOC-LI in the superficial layers disappeared after the administration of colchicine. In the brain, NOC-LI was prominent in the hypothalamus, hippocampus, cerebral peduncle, substantia nigra, dorsal raphe, periaqueductal grey, locus coeruleus and trapezoid nucleus. Colchicine treatment markedly intensified the NOC-LI in the somata of the central nervous system, whereas the untreated sections were too weak to observe and analyse. The distribution of NOC-LI provides informative data for studies of the neuronal circuit that nociceptin may be involved in.
authors.forename: H W
authors.initials: HW
authors.lastname: Kim
authors.forename: Y B
authors.initials: YB
authors.lastname: Kwon
authors.forename: T W
authors.initials: TW
authors.lastname: Ham
authors.forename: D H
authors.initials: DH
authors.lastname: Roh
authors.forename: S Y
authors.initials: SY
authors.lastname: Yoon
authors.forename: H J
authors.initials: HJ
authors.lastname: Han
authors.forename: K W
authors.initials: KW
authors.lastname: Kim
authors.forename: W S
authors.initials: WS
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Kim
authors.forename: O B
authors.initials: OB
authors.lastname: Yoon
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism*; D003078:Colchicine / Q000494:pharmacology; D005849:Gerbillinae / Q000378:metabolism / Q000502:physiology*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009619:Nociceptors / Q000378:metabolism*; D018847:Opioid Peptides / Q000276:immunology / Q000378:metabolism*; D000097629:Nociceptin
chemical_list: D003078:Colchicine; D018847:Opioid Peptides; D000097629:Nociceptin