title: Necrotizing gangrene of the genitalia and perineum.
abstract: BACKGROUND
  Necrotizing gangrene of the genitalia and perineum is a fulminant, life-threatening condition. This infection is usually polymicrobial and may be idiopathic or secondary to local trauma or surgery. Histologically, it is characterized by obliterative endarteritis and thrombosis of the subcutaneous vessels, fascial necrosis, and leukocytic infiltration. Mortality rates of 25-75% have been reported. Most cases of necrotizing gangrene begin insidiously, with scrotal discomfort and malaise. Later, erythema, increasing pain, and swelling, associated with fever and chills, develop. A biopsy is useful to confirm the clinical diagnosis and to obtain culture samples. Ultrasound imaging may reveal gas or testicular involvement and may help to distinguish this infection from other causes of scrotal pathology.
  
  
  METHODS
  Fifteen patients with necrotizing gangrene of the genitalia and perineum, seen at the Dermatology and Plastic Surgery Sections of our Institutions between 1994 and 1999, are described.
  
  
  RESULTS
  This series included 11 men (73%) and four women (27%), aged 39-68 years (mean, 51 years). In our series, Clostridium perfingens, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, Streptococcus viridans, Acinetobacter baumani, Escherichia coli, and Candida albicans were isolated. Hemodynamic stabilization and monitoring were performed in all patients. Intravenous antimicrobial therapy was promptly instituted. In most cases, two or more drugs were used. Concurrent surgical debridement of all necrotic areas was always required. When needed, split-thickness skin grafts were used to cover the penile shaft. Expanded mesh grafts were used to reconstruct the vulva and other denuded beds. The survival rate in this series was 87%.
  
  
  CONCLUSIONS
  Necrotizing gangrene of the genitalia and perineum continues to be a diagnostic and therapeutic challenge. The usual polymicrobial infection with vascular involvement demands hemodynamic stabilization, systemic antimicrobial therapy, and surgical debridement. In some patients, genital, perineal, and abdominal wall reconstruction is also required.
authors.affiliation: Dermatology and Plastic Surgery Sections, Hospital Nacional Alejandro Posadas, Buenos Aires, Argentina.
authors.forename: Hugo
authors.initials: H
authors.lastname: Cabrera
authors.forename: Luis
authors.initials: L
authors.lastname: Skoczdopole
authors.forename: Mario
authors.initials: M
authors.lastname: Marini
authors.forename: Patricia
authors.initials: P
authors.lastname: Della Giovanna
authors.forename: Alberto
authors.initials: A
authors.lastname: Saponaro
authors.forename: Cristina
authors.initials: C
authors.lastname: Echeverría
mesh_terms: D000328:Adult; D000368:Aged; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D005734:Gangrene / Q000175:diagnosis* / Q000628:therapy*; D005831:Genital Diseases, Female / Q000175:diagnosis* / Q000628:therapy*; D005832:Genital Diseases, Male / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology*; D014463:Ultrasonography