Practical synthesis of aryl triflates under aqueous conditions.
[reaction: see text] A practical and efficient synthesis of aryl triflates under biphasic basic aqueous conditions is described. The current methodology provides entry into these valuable substrates that omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good yields can also be obtained without the use of organic solvent.
Frantz
Doug E
DE
Department of Process Research, Merck Research Laboratories, Merck & Co., 466 Devon Park Drive, Wayne, Pennsylvania 19087, USA. doug_frantz@merck.com
Weaver
Damian G
DG
Carey
James P
JP
Kress
Michael H
MH
Dolling
Ulf H
UH