title: Hypoglycaemic activity of Alpinia galanga rhizome and its extracts in rabbits.
abstract: This investigation was carried out to study effects of Alpinia galanga rhizome on blood glucose levels. In normal rabbits, powdered rhizome and its methanol and aqueous extracts significantly lowered the blood glucose. Gliclazide also produced a significant decrease in blood glucose in the rabbits. In alloxan-diabetic rabbits, A. galanga and its methanol and aqueous extracts did not produce significant reduction in blood glucose. The hypoglycaemic effect of A. galanga in normal rabbits was comparable to gliclazide. The rhizome was found to contain high levels of certain minerals. Acute toxicity and behavioral studies revealed no visible signs of toxicity and any abnormal behavior in rabbits even at high doses. It is concluded that A. galanga produces fall in blood glucose levels in normal rabbits and the principles, both organic and inorganic, are extractable in methanol and water.
authors.affiliation: Postgraduate Medical Institute, Lahore, Pakistan. drmsakhtar@hotmail.com
authors.forename: M S
authors.initials: MS
authors.lastname: Akhtar
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
authors.forename: M T
authors.initials: MT
authors.lastname: Malik
mesh_terms: D000496:Alloxan; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005907:Gliclazide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008518:Medicine, East Asian Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D011817:Rabbits; D027343:Rhizome / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D005907:Gliclazide