title: Anti-herpes simplex virus effect of a seed extract from the tropical plant Licania tomentosa (Benth.) Fritsch (Chrysobalanaceae).
abstract: Incubation of acyclovir-resistant herpes simplex virus type 1 (ACVr-HSV1), during infection of the HEp-2 cell culture, with an extract prepared from the seeds of Licania tomentosa (Benth.) Fritsch (Chrysobalanaceae) species impaired the productive replication of this virus in a concentration-dependent manner. The extract was able to inhibit extracellular virus (virucidal effect) and also interfered with a very early event of cell infection, at a non-cytotoxic concentration.
authors.affiliation: Departamento de Virologia Prof. Paulo de Góes Instituto de Microbiologia, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Rio de Janeiro, Brasil. mmfsm@micro.ufrj.br
authors.forename: M M F S
authors.initials: MM
authors.lastname: Miranda
authors.forename: J L S
authors.initials: JL
authors.lastname: Gonçalves
authors.forename: M T V
authors.initials: MT
authors.lastname: Romanos
authors.forename: F P
authors.initials: FP
authors.lastname: Silva
authors.forename: L
authors.initials: L
authors.lastname: Pinto
authors.forename: M H
authors.initials: MH
authors.lastname: Silva
authors.forename: R
authors.initials: R
authors.lastname: Ejzemberg
authors.forename: L F Z
authors.initials: LF
authors.lastname: Granja
authors.forename: M D
authors.initials: MD
authors.lastname: Wigg
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001938:Brazil; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D019685:Rosales; D012639:Seeds / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts