Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patients.
The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.
Bernstein
H-G
HG
Department of Psychiatry, University of Magdeburg, D-39120 Magdeburg, Germany. Hans-Gert.Bernstein@medizin.uni-magdeburg.de
Heinemann
A
A
Krell
D
D
Mawrin
C
C
Bielau
H
H
Danos
P
P
Diekmann
S
S
Keilhoff
G
G
Bogerts
B
B
Baumann
B
B
D003866:Depressive Disorder / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007031:Hypothalamus / Q000201:enzymology* / Q000473:pathology; D007150:Immunohistochemistry; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D012016:Reference Values; D015398:Signal Transduction / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000201:enzymology* / Q000473:pathology
D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I