Antiperoxidative effects of lycopene during N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis.
The effects of lycopene on blood oxidant-antioxidant balance during N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in the presence of saturated sodium chloride (S-NaCl) as promoting agent were investigated. Enhanced lipid peroxidation in the blood of tumour-bearing animals was accompanied by significant decreases in the levels of reduced glutathione (GSH), ascorbic acid and vitamin E and the activities of glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR). Administration of lycopene significantly lowered the concentrations of lipid peroxides and enhanced antioxidant levels. We suggest that the modulatory effects of lycopene on the blood oxidant-antioxidant balance may be responsible for its chemopreventive potential.
Velmurugan
B
B
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
Bhuvaneswari
V
V
Nagini
S
S
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002338:Carotenoids / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D005982:Glutathione Transferase / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D000077276:Lycopene; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000378:metabolism* / Q000517:prevention & control; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D017392:Thiobarbituric Acid Reactive Substances; D008769:Methylnitronitrosoguanidine; D014810:Vitamin E; D002338:Carotenoids; D012965:Sodium Chloride; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D001205:Ascorbic Acid; D000077276:Lycopene