Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model.
Studies in the SIVmac macaque model have demonstrated that the extent of virus-specific CD4+ and CD8+ T-cell responses induced by vaccination prior to virus-challenge exposure correlate with viremia containment following establishment of infection. These findings led to the hypothesis that active immunization with vaccines able to induce virus-specific T-cell responses following the establishment of infection could also ameliorate the virological outcome. Here, we will review the relative effect of ART and vaccination during primary SIVmac infection of macaques.
Franchini
Genoveffa
G
National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, MD 20892-5055, USA. franchig@mail.nih.gov
Nacsa
Janos
J
Hel
Zdenek
Z
Tryniszewska
Elzbieta
E
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy*; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D014779:Virus Replication
D019380:Anti-HIV Agents