[Bronchectasia and microscopic polyangeitis].
Microscopic polyangeitis is a necrosing vascularitis with pulmonary and renal tropism. Localized in the lung, microscopic polyangeitis leads to intra-alveolar hemorrhage. We report our observations in two patients who presented with concomitant bronchectasia. The parallel course of these two conditions suggests a possible relationship. We propose a pathophysiological approach involving a direct role of polymorphonuclear neutrophils and neutrophilic proteases secreted in response to activation of anti-polymorphonuclear cytoplasm anti-bodies (ANCA) during microscopic polyangeitis aggravating bronchectasia.
Koninck
J-C
JC
Service de Pneumologie, 2 bis, boulevard Tonnellé 37000 Tours. diot@med.uni-tours.fr
Diot
E
E
Hazouard
E
E
Machet
M-C
MC
Valentin
J-F
JF
Lemarie
E
E
Diot
P
P
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001987:Bronchiectasis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008168:Lung / Q000098:blood supply*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D014657:Vasculitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D007166:Immunosuppressive Agents; D008775:Methylprednisolone