Effects of amisulpride on consummatory negative contrast.
Two groups of rats, 'shifted' (32-4% sucrose) and 'unshifted' (4-4% sucrose), were given access to sucrose solutions for 5 min/day for 10 days. On day 11, shifted animals had access to a devalued incentive (4% sucrose) and subgroups of each group received doses of amisulpride (10 or 60 mg/kg, i.p.) or its vehicle before a 10-min access period to sucrose solutions. Lick frequency was measured both pre- and post-shift. A high dose of amisulpride reduced successive negative contrast (SNC) after a brief period of exposure to the devalued stimulus, whereas a low dose had no effect. The acute effects of high doses of amisulpride seem to act on contrast effects in a similar way to anxiolytic compounds such as the benzodiazepine, chlordiazepoxide.
Genn
R F
RF
Department of Psychology, University of British Columbia, Vancouver, Canada. rachel.f.genn@kcl.ac.uk
Barr
A M
AM
Phillips
A G
AG
D000077582:Amisulpride; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003259:Consummatory Behavior / Q000187:drug effects*; D015350:Contrast Sensitivity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride