[Teicoplanin in the prophylaxis of surgical infections and bacterial endocarditis].
Antibiotic prophylaxis has become a standard of care in all surgical categories, since its impact in reducing the incidence of post-operative infections has now been well established. Antibiotic prophylaxis should target expected pathogens. Glycopeptide-based regimens have been considered a choice for surgical procedures, since Gram-positive bacteria are the pathogens most commonly isolated from wound infections. In orthopedics, cardiac, vascular and other clean surgical procedures, staphylococci (S. aureus and coagulase-negative staphylococci) are responsible for 70-90% of post-surgical infections. The isolation of methicillin-resistant strains has also risen to alarmingly high rates. This article focuses on the results of clinical trials on the efficacy of teicoplanin as prophylaxis in clean surgical procedures.
Nacinovich
Francisco
F
Fundación del Centro de Estudios Infectológicos (FUNCEI), French 3037, 1425 Buenos Aires, Argentina.
Stamboulian
Daniel
D
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D013504:Cardiovascular Surgical Procedures; D004697:Endocarditis, Bacterial / Q000517:prevention & control*; D006801:Humans; D019637:Orthopedic Procedures; D013530:Surgical Wound Infection / Q000517:prevention & control*; D017334:Teicoplanin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin