title: Sensitive through-space dipolar correlations between nuclei of small organic molecules by partial alignment in a deuterated liquid solvent.
abstract: Through-space residual dipolar correlations in NMR spectra can be measured between nuclei of small organic molecules by partially aligning them with respect to the magnetic field in a pure deuterated liquid solvent, 4-pentyl-4'-cyanobiphenyl. A simple temperature change of this liquid phase enables spectra to be compared between samples under isotropic tumbling conditions and weakly oriented anisotropic states. This should provide access of a number of small nonpolar molecules to more sensitive through-space nuclear correlations than possible through NOE experiments, depending on the net orientation of specific nuclear pairs with respect to the magnetic field and the specific coherence transfers employed.
authors.affiliation: Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Campus Box B111, 4200 East Ninth Avenue, Denver, CO 80262, USA. brad.bendiak@uchsc.edu
authors.forename: Brad
authors.initials: B
authors.lastname: Bendiak
mesh_terms: D016880:Anisotropy; D001713:Biphenyl Compounds / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009570:Nitriles / Q000737:chemistry; D010616:Phenanthrenes / Q000737:chemistry; D012680:Sensitivity and Specificity; D012997:Solvents
chemical_list: D001713:Biphenyl Compounds; D009570:Nitriles; D010616:Phenanthrenes; D012997:Solvents; C433919:4-cyano-4'-pentylbiphenyl; D003903:Deuterium