title: Tumor-derived exosomes: a new source of tumor rejection antigens.
abstract: Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines.
authors.affiliation: Unite d'immunologie, Immunology Unit, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805 Villejuif Cedex, France. uimmunoc@igr.fr
authors.forename: F
authors.initials: F
authors.lastname: André
authors.forename: N E C
authors.initials: NE
authors.lastname: Schartz
authors.forename: N
authors.initials: N
authors.lastname: Chaput
authors.forename: C
authors.initials: C
authors.lastname: Flament
authors.forename: G
authors.initials: G
authors.lastname: Raposo
authors.forename: S
authors.initials: S
authors.lastname: Amigorena
authors.forename: E
authors.initials: E
authors.lastname: Angevin
authors.forename: L
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D006801:Humans; D051379:Mice
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines