Intercellular adhesion molecule-1 in the heart.
Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.
Niessen
Hans W M
HW
Department of Pathology, ICaR-VU, VU University Medical Center, Amsterdam, the Netherlands. jmw.niessen@vumc.nl
Krijnen
Paul A J
PA
Visser
Cees A
CA
Meijer
Chris J L M
CJ
Hack
C Erik
CE
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology / Q000503:physiopathology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D009203:Myocardial Infarction / Q000235:genetics; D009206:Myocardium / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors; D018799:Intercellular Adhesion Molecule-1