title: MnDPDP enhanced magnetic resonance imaging of focal liver lesions.
abstract: Mangafodipir trisodium (MnDPDP) is a contrast agent for use in magnetic resonance imaging (MRI) of the liver. The agent is taken up by normal hepatocytes resulting in increased signal on T1-weighted imaging, and is excreted in the biliary system. Hepatocyte-containing liver neoplasms such as hepatomas or focal nodular hyperplasia (FNH), take up MnDPDP and demonstrate varying degrees of enhancement. Metastatic liver deposits and primary liver tumours of non-hepatocyte origin do not typically enhance with MnDPDP thus increasing their conspicuity compared with pre-contrast T1-weighted images. Metastases may demonstrate rim enhancement particularly on delayed imaging at 24 h, which can increase their conspicuity, thus allowing better visualization of small lesions. Functional biliary obstruction due to liver metastases can also result in wedge shaped areas of parenchymal enhancement. The MRI features of various focal liver after continuance with lesions following MnDPDP are discussed and illustrated including primary lesions such as hepatoma and secondary metastases.
authors.affiliation: Department of Radiology, Chelsea and Westminster Hospital, London, UK.
authors.forename: L J
authors.initials: LJ
authors.lastname: King
authors.forename: G J C
authors.initials: GJ
authors.lastname: Burkill
authors.forename: E D
authors.initials: ED
authors.lastname: Scurr
authors.forename: P
authors.initials: P
authors.lastname: Vlavianos
authors.forename: I
authors.initials: I
authors.lastname: Murray-Lyons
authors.forename: J C
authors.initials: JC
authors.lastname: Healy
mesh_terms: D018248:Adenoma, Liver Cell / Q000175:diagnosis; D000328:Adult; D000368:Aged; D018281:Cholangiocarcinoma / Q000175:diagnosis; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid