title: [In vivo activity of amoxicillin in a non-toxigenic Corynebacterium diphtheriae rabbit endocarditis experimental model].
abstract: The mortality of non-toxigenic Corynebacterium diphtheriae endocarditis is high (27%). One explanation could be tolerance to amoxicillin. The aim of this work was to evaluate in vivo the tolerance phenomenon, in a rabbit endocarditis experimental model. Two strains of non-toxigenic Corynebacterium diphtheriae were compared: a tolerant one and a non-tolerant one. EACH ANIMAL WAS RANDOMLY ASSIGNED TO ONE OF THE FOLLOWING GROUPS: no treatment, continuous infusion of amoxicillin simulating 200 mg/kg/24 h in humans, or fractionated infusion of amoxicillin simulating 66 mg/kg/8 h in humans. Surviving bacteria were counted in vegetations after one or three days of treatment. The 24 h fractionated amoxicillin infusion was more efficacious on the non-tolerant strain than on the tolerant strain. On the tolerant strain, 24 h amoxicillin was more efficacious as a continuous infusion than as a fractionated one.
authors.affiliation: Laboratoire d'antibiologie, Faculté de Médecine, 1, rue Gaston-Veil, 44035, Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Grandière-Perez
authors.forename: C
authors.initials: C
authors.lastname: Jacqueline
authors.forename: V
authors.initials: V
authors.lastname: Le Mabecque
authors.forename: O
authors.initials: O
authors.lastname: Patey
authors.forename: G
authors.initials: G
authors.lastname: Potel
authors.forename: D
authors.initials: D
authors.lastname: Bugnon
authors.forename: J
authors.initials: J
authors.lastname: Caillon
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D003353:Corynebacterium diphtheriae; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D011817:Rabbits; D012016:Reference Values
chemical_list: D000658:Amoxicillin