Intracellular targeting of protein kinases and phosphatases.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.
Alto
Neal
N
Howard Hughes Medical Institute, Vollum Institute, Portland, Oregon 97201-3098, USA.
Carlisle Michel
Jennifer J
JJ
Dodge
Kimberly L
KL
Langeberg
Lorene K
LK
Scott
John D
JD
D000199:Actins / Q000502:physiology; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000201:enzymology*; D008565:Membrane Proteins / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D000199:Actins; D008565:Membrane Proteins; D011494:Protein Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D010744:Phosphoric Monoester Hydrolases