[Development of renal tumors in rats on intermittently injected methylcholanthrene and nitrosodimethylamine].
Experiments on 892 non-inbred male rats studied the development of renal tumors in the animals intermittently administered two substances different in the mechanism of carcinogenic action. Renal pre-injection of methylcholantherene (MC) in a small dose insufficient to induce renal tumors in the study period, followed by dermal applications of this agent was shown to enhance a blastomogenic effect, as manifested by both early occurrence of precarcinogenic changes and early development of renal tumors at the site of primary injection of MC into the kidney. The effect of nitrosodimethylamine (NDMA) intermittently injected in a nephrotropic dose was studied in the second series of the experiments. The intermittent injection of NDMA in courses during 8 weeks gave rise to renal tumors in the early period, caused increases in the number of tumors and in the area of renal tumor proliferates. The mechanism of enhanced renal blastomogenesis is discussed in terms of the mechanisms responsible for initiation and progression.
Beliaeva
N M
NM
Matchin
G A
GA
D000818:Animals; D004128:Dimethylnitrosamine / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008748:Methylcholanthrene / Q000008:administration & dosage / Q000009:adverse effects*; D010507:Periodicity; D051381:Rats
D008748:Methylcholanthrene; D004128:Dimethylnitrosamine