[Pouchitis--pathophysiology and therapy].
Ulcerative colitis can be cured with a reasonable quality of life by the complete excision of the colorectum and construction of an ileoanal pouch. The cure is incomplete since there is a certain incidence of a so called pouchitis. Pouchitis occurs with a frequency of 36 %. A single episode of a pouchitis can be cured easily, but in 8-32 % the concerned patients develop a chronic pouchitis. There are many signs that pouchitis might be a remanifestation of ulcerative colitis. This article gives an overview on the actual state of pathophysiology, pathogenesis and therapy of this disease. Apart of that the surgical aspects of the disease are described.
Kroesen
A J
AJ
Chirurgische Klinik und Poliklinik I, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
Schreiber
S
S
Buhr
H J
HJ
D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000503:physiopathology; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D019449:Pouchitis / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy