title: Hyperoxaluric calcium nephrolithiasis.
abstract: Hyperoxaluria leads to increased calcium oxalate supersaturation and calcium oxalate stone formation. Excess oxalate can arise from endogenous overproduction as in primary hyperoxaluria or from dietary sources. In the last 15 years great strides have been made in the diagnosis and treatment of primary hyperoxaluria. However options still seem limited in treating the mild hyperoxaluria found in many stone formers. Inadequate knowledge of food oxalate content, the effect of dietary oxalate precursors on oxalate excretion, and the factors affecting handling of oxalate by the intestine prevent development of rational therapies for treatment of hyperoxaluria. Recent studies of oxalate degrading bacteria and renewed interest in the role of diet calcium in oxalate absorption may lead to better therapeutic strategies for hyperoxaluric calcium nephrolithiasis.
authors.affiliation: University of Chicago and Litholink Corporation, 2250 W. Campbell Park Drive, Chicago, IL 60612, USA. jasplin@litholink.com
authors.forename: John R
authors.initials: JR
authors.lastname: Asplin
mesh_terms: D000293:Adolescent; D002129:Calcium Oxalate / Q000378:metabolism* / Q000652:urine; D002136:Calcium, Dietary / Q000378:metabolism; D002648:Child; D004044:Dietary Proteins / Q000378:metabolism; D004326:Drinking; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000378:metabolism* / Q000628:therapy / Q000652:urine; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000378:metabolism* / Q000628:therapy / Q000652:urine; D020347:Lithiasis / Q000378:metabolism* / Q000628:therapy / Q000652:urine; D011736:Pyridoxine / Q000627:therapeutic use
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D002129:Calcium Oxalate; D011736:Pyridoxine