title: Comparison of calcium alginate film with collagen membrane for guided bone regeneration in mandibular defects in rabbits.
abstract: OBJECTIVE
  We sought to compare calcium alginate film (CAF) with collagen membrane (CM) regarding their effects on guided bone regeneration.
  
  
  METHODS
  Circular bone defects with 5-mm diameter were created in the region anterior to both mandibular angles in 34 rabbits. The defects on one side were covered with a CAF, and the contralateral side with CM. Healing condition was analyzed with gross, radiographic, electromicroscopic, histologic, and immunohistochemical studies and image pattern analysis system after 1, 2, 4, 6, and 8 weeks.
  
  
  RESULTS
  CM absorbed more slowly but collected fewer osteoinductive factors (P <.05) in the early period. CAF induced dense bone formation, whereas CM produced less newly formed bone.
  
  
  CONCLUSIONS
  CAF is more efficacious than CM in guided bone regeneration in this animal model.
authors.affiliation: Received from the Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Medical College, Zhe Jiang University, Hang Zhou, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Jianqi
authors.forename: He
authors.initials: H
authors.lastname: Hong
authors.forename: Sheng
authors.initials: S
authors.lastname: Lieping
authors.forename: Gu
authors.initials: G
authors.lastname: Genghua
mesh_terms: D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D003094:Collagen; D020723:Glucuronic Acid; D048091:Guided Tissue Regeneration / Q000379:methods*; D006603:Hexuronic Acids; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011817:Rabbits
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D020723:Glucuronic Acid; D003094:Collagen