title: Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection.
abstract: We report a patient with primary amenorrhea accompanied by adrenal adenoma. A 21-year-old woman was admitted to our hospital because of primary amenorrhea and hyperprogesteronemia without virilization. Venous sampling showed progesterone overproduction at the left adrenal gland. Computed tomography revealed a 7 cm mass in left adrenal gland. Serum pregnenorone, 17-hydroxypregnenorone, dehydroepiandrosterone, 17-hydroxyprogesterone, deoxycorticosterone, and 11-deoxycortisol were elevated. The diagnosis of steroid hormone producing tumor was made. Following tumor resection, serum progesterone normalized 4 days later, and menarche occurred 51 days after operation. The present case indicated that adrenal functioning tumor should not be overlooked in patients with primary amenorrhea.
authors.affiliation: First Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Ninomiya
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Minoru
authors.initials: M
authors.lastname: Sato
authors.forename: Yukio
authors.initials: Y
authors.lastname: Koibuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Miho
authors.initials: M
authors.lastname: Yoshida
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Odawara
authors.forename: Takao
authors.initials: T
authors.lastname: Yokoe
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Iino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishita
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000601:surgery; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D008572:Menarche