title: A limited form of Wegener's granulomatosis with bronchiolitis obliterans organizing pneumonitis-like variant in an ulcerative colitis patient.
abstract: A case of a 19-year-old man with ulcerative colitis (UC) developed multiple pulmonary nodular shadows with cavity formation, elevated perinuclear antinuclear cytoplasmic antibody (pANCA) and positive lymphocyte stimulation test by drug (DLST) for mesalazine suggesting mesalazine induced Wegener's granulomatosis (WG). Transbronchial biopsy specimens were consistent with WG and thoracoscopic biopsy specimens were consistent with bronchiolitis obliterans organizing pneumonitis (BOOP). We diagnosed WG with BOOP-like variant, which was induced by mesalazine. To our knowledge, this is the first report of a limited form of WG associated with orally administered mesalazine.
authors.affiliation: Department of Pulmonary Medicine, National Matsue Hospital, Matsue, Shimane.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yano
authors.forename: Kanako
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kato
authors.forename: Kengo
authors.initials: K
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications*; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D008297:Male