title: Cyclic alkenenitriles: chemoselective oxonitrile cyclizations.
abstract: Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclization, and dehydration efficiently transform a diverse array of omega-oxonitriles into carbocyclic and heterocyclic five- and six-membered alkenenitriles in a single synthetic operation.
authors.affiliation: Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530, USA. flemingf@duq.edu
authors.forename: Fraser F
authors.initials: FF
authors.lastname: Fleming
authors.forename: Lee A
authors.initials: LA
authors.lastname: Funk
authors.forename: Ramazan
authors.initials: R
authors.lastname: Altundas
authors.forename: Vaqar
authors.initials: V
authors.lastname: Sharief