Continent jejunal reservoir dialysis for end-stage renal disease: is it possible?
With limited organs available for renal transplantation in comparison with the number of patients on the waiting list, and with the drawbacks of dialysis, other forms of treatment for end-stage renal disease (ESRD) need to be investigated. We propose that using a reconfigured segment of bowel as a reservoir in which dialysate of various compositions can be instilled to remove metabolic wastes usually handled by the kidney may augment or replace renal function in a uremic patient. We have chosen the jejunum and have documented our preliminary findings using hyperosmotic dialysate along with the unique characteristics of continent jejunal reservoir dialysis (CJRD). With further refinements, CJRD may eventually be offered as an alternative treatment for ESRD.
Moore
Debora K
DK
University of Oklahoma, College of Medicine, Oklahoma City, Oklahoma 73190, USA.
Kwon
Eugene E
EE
Donovan
James F
JF
D000818:Animals; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D002413:Cations, Divalent / Q000378:metabolism; D039021:Colonic Pouches / Q000502:physiology; D003956:Dialysis / Q000379:methods*; D015314:Dialysis Solutions / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006982:Hypertonic Solutions / Q000494:pharmacology; D007552:Isotonic Solutions / Q000494:pharmacology; D007583:Jejunum / Q000502:physiology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D009997:Osmotic Pressure; D019651:Plastic Surgery Procedures / Q000379:methods*; D016019:Survival Analysis; D014547:Urinary Diversion / Q000379:methods / Q000401:mortality; D016476:Urinary Reservoirs, Continent / Q000502:physiology
D002413:Cations, Divalent; D015314:Dialysis Solutions; D006982:Hypertonic Solutions; D007552:Isotonic Solutions