title: Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development.
abstract: Extracellular Fatty Acid Binding Protein (Ex-FABP) is a 21 kDa lipocalin, expressed during chicken embryo development in hypertrophic cartilage, in muscle fibres and in blood granulocyte. The protein selectively binds with high affinity fatty acids, preferably long chain unsaturated fatty acids in chondrocyte and myoblast cultures Ex-FABP expression is increased by inflammatory-agents and repressed by anti-inflammatory-agents. In adult cartilage, Ex-FABP is expressed only in pathological conditions such as in dyschondroplastic and osteoarthritic chicken cartilage. We propose that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro, Centro Biotecnologie Avanzate, Genova, Italy. descalzi@cba.unige.it
authors.forename: Fiorella
authors.initials: F
authors.lastname: Descalzi Cancedda
authors.forename: Beatrice
authors.initials: B
authors.lastname: Dozin
authors.forename: Barbara
authors.initials: B
authors.lastname: Zerega
authors.forename: Silvia
authors.initials: S
authors.lastname: Cermelli
authors.forename: Chiara
authors.initials: C
authors.lastname: Gentili
authors.forename: Ranieri
authors.initials: R
authors.lastname: Cancedda
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D030161:Avian Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D002642:Chick Embryo / Q000254:growth & development* / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D054835:Lipocalin 1; D054834:Lipocalins
chemical_list: D000893:Anti-Inflammatory Agents; D030161:Avian Proteins; D002352:Carrier Proteins; C066299:Ch21 protein, chicken; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D054835:Lipocalin 1; D054834:Lipocalins