title: Cavernous sinus involvement by extramedullary plasmacytoma of the sphenoid sinus. An argument for the use of adjuvant chemotherapy.
abstract: A 63-year-old man with cavernous sinus involvement from extramedullary plasmacytoma (EMP) of the sphenoid sinus is described. Transient resolution of retro-orbital headache and continued progression of the locally extensive tumor were noted after chemotherapy was given following a poor response to 5400 cGy of local irradiation. To determine whether adjunctive chemotherapy will improve the outcome of these particular patients, we propose that a randomized trial comparing radiotherapy to chemoradiation be conducted.
authors.affiliation: Division of Radiation Oncology, Department of Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Federico L
authors.initials: FL
authors.lastname: Ampil
authors.forename: T Greg
authors.initials: TG
authors.lastname: Borski
authors.forename: Cherie Ann O
authors.initials: CO
authors.lastname: Nathan
authors.forename: Gregory
authors.initials: G
authors.lastname: Mulcahy
authors.forename: Michael
authors.initials: M
authors.lastname: Walker
authors.forename: Hong W
authors.initials: HW
authors.lastname: Chin
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Stucker
mesh_terms: D000368:Aged; D002426:Cavernous Sinus / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D004172:Diplopia; D006261:Headache; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy*; D010954:Plasmacytoma / Q000175:diagnosis / Q000628:therapy*; D013812:Therapeutics