Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation?
Accumulating evidence indicates that in addition to the classical complex, the catalytic and regulatory subunits of CK2 can also exist as free populations in living cells. The association of recombinant CK2 subunits in vitro has been characterized, providing evidence for the first time for their targeted interactions in living cells. The data also suggest that the regulation by phosphorylation of many CK2 substrates may strongly depend on the dynamic localization/association of its subunits.
Martel
Véronique
V
INSERM EMI 104, Département de Biologie Moléculaire et Structurale, CEA, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Filhol
Odile
O
Nueda
Arsenio
A
Cochet
Claude
C
D016475:3T3 Cells; D000818:Animals; D047390:Casein Kinase II; D017930:Genes, Reporter; D007700:Kinetics; D051379:Mice; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*; D021122:Protein Subunits; D011994:Recombinant Proteins / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D014162:Transfection
D021122:Protein Subunits; D011994:Recombinant Proteins; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases