Characterization of reperfused infarcted myocardium from high-frequency intracardiac ultrasound imaging using homodyned K distribution.
Myocardial changes caused by infarction/reperfusion (contraction band necrosis, hemorrhage, edema, etc.) may result in an increased scatterer density and a variation in scatterer arrangement. This paper, for the first time, models most of the scattering conditions resulting from the interaction of ultrasound and normal/reperfused infarcted myocardium using the homodyned K distribution. Furthermore, this method is used to characterize the change in scatterer density by calculating the effective scatterer number per resolution cell. The reliability and the effects of attenuation and scan conversion on effective scatterer number estimation are discussed. We used in vivo data acquired using high-frequency intracardiac ultrasound imaging (8.5 MHz) from the left and right ventricles of open-chest pigs in an acute infarction/reperfusion model. The results show that the homodyned K distribution describes the statistical distribution of backscattered signal from both normal and abnormal myocardium. A significant increase in scatterer density occurs in the infarcted region after reperfusion compared with the same region at baseline (normal myocardium prior to occlusion). The scatterer density of the normal region does not change significantly after reperfusion. We conclude that the homodyned K distribution may characterize normal and reperfused infarcted myocardium using high-frequency intracardiac ultrasound images.
Hao
Xiaohui
X
Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN 55905, USA. Xiaohui.Hao@med.ge.com
Bruce
Charles J
CJ
Pislaru
Cristina
C
Greenleaf
James F
JF
D000818:Animals; D003198:Computer Simulation; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D007089:Image Enhancement / Q000379:methods*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000000981:diagnostic imaging*; D012016:Reference Values; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013552:Swine