title: Insulin and oral antidiabetic agents for treatment of polycystic ovary syndrome.
abstract: Insulin plays a major role in polycystic ovary syndrome (PCOS). Insulin resistance and resultant hyperinsulinemia stimulate both the ovary and adrenal to produce androgens. Oral antidiabetic agents have been used to alleviate the symptoms and to induce ovulation in women with PCOS. This review focuses on the relation between insulin and PCOS and discusses the use of oral antidiabetic agents.
authors.affiliation: Department of Obstetrics and Gynecology, Celal Bayar University, School of Medicine, Manisa, Turkey.
authors.forename: Naci K
authors.initials: NK
authors.lastname: Kuscu
authors.forename: Faik M
authors.initials: FM
authors.lastname: Koyuncu
mesh_terms: D000284:Administration, Oral; D002839:Chromans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D013844:Thiazoles / Q000627:therapeutic use*; D045162:Thiazolidinediones; D000077288:Troglitazone
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D045162:Thiazolidinediones; D008687:Metformin; D000077288:Troglitazone