Tensor diffusion imaging in B12 leukoencephalopathy.
Anisotropy measurements were obtained from periventricular foci of T2 prolongation and adjacent normal-appearing white matter in a case of B12 leukoencephalopathy. Measurements were compared with mean values from two age-matched control subjects. Anisotropy was greatly reduced in the lesions evident on T2-weighted images and in the normal-appearing adjacent white matter (WM), indicating that the extent of WM tract disruption was greater than could be identified on routine MR sequences.
Kealey
Susan M
SM
Department of Radiology, Duke University Medical Center, Box 3808, Rm. 1533, Erwin Road, Durham, NC 27710-3808, USA. susankealey@hotmail.com
Provenzale
James M
JM
D002540:Cerebral Cortex / Q000473:pathology*; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014806:Vitamin B 12 Deficiency / Q000150:complications*