title: Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences.
abstract: Histone mRNA metabolism is tightly coupled to cell cycle progression and to rates of DNA synthesis. The recent identification of several novel proteins involved in histone gene transcription and pre-mRNA processing has shed light on the variety of mechanisms cells employ to achieve this coupling.
authors.affiliation: Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: William F
authors.initials: WF
authors.lastname: Marzluff
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Duronio
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002453:Cell Cycle; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000096:biosynthesis / Q000235:genetics*; D008957:Models, Genetic; D009866:Oogenesis; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D012322:RNA Precursors; D012333:RNA, Messenger