Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses.
Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth of the tumor was destructive, there was extensive lung metastasis, and the outcome was unfavorable. Ultrastructural and immunohistochemical examination showed the spindle-cell component of the tumor to be epithelial in character. A gain of 5q with amplification of 5q13 was detected in the tumor by comparative genomic hybridization.
Kawauchi
Shigeto
S
Department of Pathology, Yamaguchi University School of Medicine, Japan. shig@po.cc.yamaguchi-u.ac.jp
Hayatsu
Yoshikazu
Y
Takahashi
Mutsuo
M
Furuya
Tomoko
T
Oga
Atsunori
A
Niwa
Shin-Ichiro
S
Sasaki
Kohsuke
K
D000368:Aged; D000564:Ameloblastoma / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D002296:Carcinosarcoma / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D005784:Gene Amplification; D006801:Humans; D007124:Immunoenzyme Techniques; D007564:Japan; D007573:Jaw Neoplasms / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D007621:Karyotyping; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods; D012509:Sarcoma / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure