title: A diffusion tensor MRI study of basal ganglia from patients with ADEM.
abstract: Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ((-)D) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average (-)D (p=0.02) and lower (-)D histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
authors.forename: Markus
authors.initials: M
authors.lastname: Holtmannspötter
authors.forename: Matilde
authors.initials: M
authors.lastname: Inglese
authors.forename: Marco
authors.initials: M
authors.lastname: Rovaris
authors.forename: Maria Assunta
authors.initials: MA
authors.lastname: Rocca
authors.forename: Maria
authors.initials: M
authors.lastname: Codella
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000473:pathology*; D004673:Encephalomyelitis, Acute Disseminated / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012016:Reference Values