title: Circulating IL-8 and IL-10 in euthyroid sick syndromes following bone marrow transplantation.
abstract: It is generally agreed that euthyroid sick syndromes (ESS) are associated with an increased production of cytokines. However, there has been scarce data on the relationship thyroid hormone changes and cytokines among the patients undergoing bone marrow transplantation (BMT). Because interleukin-8 (IL-8) has been identified as a potent proinflammatory and interleukin-10 (IL-10) as an antiinflammatory cytokine, we studied the relation between thyroid hormone parameters and these cytokines following BMT. We studied 80 patients undergoing allogeneic BMT. Serum T3 decreased to nadir at post-BMT 3 weeks. Serum T4 was the lowest at the post-BMT 3 months. Serum TSH sharply decreased to nadir at 1 week and gradually recovered. Serum free T4 significantly increased during 3 weeks and then returned to basal level. Mean levels of serum IL-8 significantly increased at 1 week after BMT. Mean levels of serum IL-10 significantly increased until 4 weeks after BMT. No significant correlation was found between serum thyroid hormone parameters and cytokines (IL-8, IL-10) after adjusting steroid doses during the entire study period. In conclusion, ESS developed frequently following allogeneic BMT and cytokine levels were increased in post-BMT patients. However, no significant correlation was found between serum thyroid hormone parameters and these cytokines.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Drlwy@samsung.co.kr
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Jung Yul
authors.initials: JY
authors.lastname: Suh
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Oh
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Moo Il
authors.initials: MI
authors.lastname: Kang
authors.forename: Kwang Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Choon Choo
authors.initials: CC
authors.lastname: Kim
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005067:Euthyroid Sick Syndromes / Q000097:blood*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
chemical_list: D016209:Interleukin-8; D014284:Triiodothyronine; D016753:Interleukin-10; D013974:Thyroxine