IL-28, IL-29 and their class II cytokine receptor IL-28R.
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.
Sheppard
Paul
P
ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, WA 98102, USA.
Kindsvogel
Wayne
W
Xu
Wenfeng
W
Henderson
Katherine
K
Schlutsmeyer
Stacy
S
Whitmore
Theodore E
TE
Kuestner
Rolf
R
Garrigues
Ursula
U
Birks
Carl
C
Roraback
Jenny
J
Ostrander
Craig
C
Dong
Dennis
D
Shin
Jinu
J
Presnell
Scott
S
Fox
Brian
B
Haldeman
Betty
B
Cooper
Emily
E
Taft
David
D
Gilbert
Teresa
T
Grant
Francis J
FJ
Tackett
Monica
M
Krivan
William
W
McKnight
Gary
G
Clegg
Chris
C
Foster
Don
D
Klucher
Kevin M
KM
D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D003001:Cloning, Molecular; D016207:Cytokines; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D021122:Protein Subunits; D012313:RNA / Q000235:genetics / Q000378:metabolism; D018121:Receptors, Cytokine / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology; D000095022:Interferon Lambda
D016207:Cytokines; D007372:Interferons; D007378:Interleukins; D021122:Protein Subunits; D012313:RNA; D018121:Receptors, Cytokine; D011994:Recombinant Proteins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C471046:interleukin 28alpha receptor