Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
OBJECTIVE
To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.


METHODS
Interventional case report.


METHODS
A full-thickness section of canaliculus was obtained during surgical repair.


METHODS
Histopathologic changes in the specimen.


RESULTS
The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen.


CONCLUSIONS
Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
Agarwal
Madhu R
MR
Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Esmaeli
Bita
B
Burnstine
Michael A
MA
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy; D003608:Dacryocystorhinostomy; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007765:Lacrimal Apparatus / Q000187:drug effects* / Q000473:pathology* / Q000601:surgery; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced* / Q000473:pathology; D008679:Metaplasia
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil