title: Erythema gyratum repens responding to cetirizine hydrochloride.
abstract: We report a case of erythema gyratum repens (EGR) in a 59-year-old man with inoperable pancreatic cancer and liver metastasis. The patient had a widespread erythema with concentric marginal band spreading in waves over the trunk and extremities. Numerous vesicles were seen on the margin of the erythema. The skin lesions were severely pruritic, and his peripheral blood showed marked eosinophilia. He also had palmoplantar hyperkeratosis. A biopsy specimen of the erythema disclosed spongiosis, microvesicles filled with eosinophils, infiltration of eosinophils into the epidermis, and a perivascular infiltrate in the dermis. The skin lesions and pruritus cleared quickly after the administration of cetirizine hydrochloride.
authors.affiliation: Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Miyagawa
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Danno
authors.forename: Masami
authors.initials: M
authors.lastname: Uehara
mesh_terms: D000284:Administration, Oral; D001707:Biopsy, Needle; D017332:Cetirizine / Q000008:administration & dosage*; D018450:Disease Progression; D004892:Erythema Multiforme / Q000175:diagnosis* / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care / Q000379:methods; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis*; D012720:Severity of Illness Index
chemical_list: D017332:Cetirizine