title: The decomposition of thionitrites.
abstract: The mechanism of thionitrite decomposition, both in vivo and in vitro, remains unclear. Thionitrite stability is highly variable; it is a complex function of thionitrite structure and environmental condition. Several recent advances clarify the role of unimolecular homlytic decomposition, metal-catalyzed reductive decomposition and higher-order enzymatic and non-enzymatic processes to the overall observed stability of thionitrites.
authors.affiliation: The Howard Hughes Medical Institute and Department of Medicine, MSRB Room 312, Duke University Medical Center, Durham, NC 27710, USA. staml001@mc.duke.edu
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Stamler
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Toone
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004355:Drug Stability; D006801:Humans; D007700:Kinetics; D009569:Nitric Oxide / Q000737:chemistry; D009573:Nitrites / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry
chemical_list: D009573:Nitrites; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D013455:Sulfur; D003300:Copper; D000445:Aldehyde Oxidoreductases; D010100:Oxygen