[Endocrine tumors of the pancreas: classification, clinical and molecular prognostic factors].
Pancreatic endocrine tumors are uncommon. Although the great majority of these tumors are well differentiated, their malignant potential varies sometimes greatly. Thus, a variety of clinicopathologic features have been developed in the past to assist in distinguishing pancreatic endocrine tumors with benign, indeterminate and aggressive behavior. Recently, a revised classification of pancreatic endocrine tumors has been proposed including, in addition to previous parameters, the number of mitoses and a Ki-67 index. In this review, the potential diagnostic utility of these different criteria is discussed.
Terris
Benoît
B
Service d'Anatomie Pathologique, Hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75679 Paris Cedex 14, France. benoit.terris@cch.ap-hop-paris.fr
D004701:Endocrine Gland Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D011379:Prognosis