Sensorimotor polyneuropathy after a three-month oral acitretin therapy.
We report a patient with chronic plaque psoriasis who developed clinical and electrophysiologic features of polyneuropathy affecting motor and sensory fibers in upper and lower extremities after three months of treatment with oral acitretin. Drug withdrawal resulted in a complete clinical recovery and normalization of all electrophysiologic abnormalities within two months.
Chroni
E
E
Department of Neurology, University of Patras, Rio-Patras, Greece. echroni@yahoo.com
Monastirli
A
A
Pasmatzi
E
E
Sakkis
Th
T
Georgiou
S
S
Paschalis
C
C
Tsambaos
D
D
D017255:Acitretin / Q000009:adverse effects* / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011115:Polyneuropathies / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy; D013997:Time Factors
D007641:Keratolytic Agents; D017255:Acitretin