title: Highly enantioselective rhodium-catalyzed hydrogenation of beta-dehydroamino acid derivatives using monodentate phosphoramidites.
abstract: New and very easily accessible monodentate phosphoramidite ligands have been developed that lead to excellent ee's and full conversions in the hydrogenation of (E)- and (Z)-beta-dehydroamino acid derivatives with both aliphatic and aromatic side chains. Particularly, two different catalytic systems were established for (E)-beta-(acylamino)acrylates (98-99% ee) and (Z)-beta-(acylamino)acrylates (92-95% ee) based on phosphoramidites 2 and 3, respectively.
authors.affiliation: Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Diego
authors.initials: D
authors.lastname: Peña
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Johannes G
authors.initials: JG
authors.lastname: De Vries
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012238:Rhodium