Zebrafish gastrulation movements: bridging cell and developmental biology.
During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.
Heisenberg
Carl Philipp
CP
Max-Planck-Institute for Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307, Dresden, Germany. heisenberg@mpi-cbg.de
Tada
Masazumi
M
D000818:Animals; D002465:Cell Movement / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005775:Gastrula / Q000166:cytology*; D009154:Mutation; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics