The pharmacology of gastrointestinal nociceptive pathways.
The principal conscious sensations that arise from the gastrointestinal tract are discomfort and pain. Chronic visceral discomfort and pain are generally managed poorly with currently available pharmacological agents. Receptors and ion channels present on extrinsic visceral primary afferent (sensory) neurons are targets for the development of new pharmacological strategies for control of visceral pain.
Blackshaw
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Nerve-Gut Research Laboratory, Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, North Terrace, South Australia 5000, Adelaide, Australia. gf-gebhart@uiowa.edu
Gebhart
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GF
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D004064:Digestive System / Q000187:drug effects* / Q000294:innervation* / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism; D009619:Nociceptors / Q000502:physiology*
D005765:Gastrointestinal Agents; D009414:Nerve Growth Factors