title: Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation.
abstract: OBJECTIVE
  To compare ovarian response to controlled ovarian hyperstimulation (COH) between normal ovaries and ovaries previously treated surgically for unilateral ovarian endometrioma.
  
  
  METHODS
  From January 1996 to December 2001, 32 patients with unilateral ovarian endometrioma previously treated surgically underwent 38 cycles of COH. Their records were reviewed retrospectively. The number of dominant follicles observed on the day of hCG injection and the number of eggs retrieved from the diseased and the normal ovaries in each patient were compared.
  
  
  RESULTS
  The numbers of dominant follicles from diseased and normal ovaries were 1.9 +/- 1.5 and 3.3 +/- 2.1, respectively (P < 0.001). During ovum pick up, the numbers of eggs retrieved from diseased and normal ovaries were 2.9 +/- 2.6 and 6.1 +/- 4.1, respectively (P < 0.0001). For diseased ovaries, 21.1% (8/38) had no dominant follicles, while only 7.9% (3/38) of normal ovaries lacked dominant follicles. The clinical pregnancy rate and the implantation rate per embryo transfer were 33.3 and 17.6%.
  
  
  CONCLUSIONS
  Surgery for ovarian endometrioma may damage ovarian reserve. It potentially results in poor ovarian response to COH, compared to the response of the contralateral normal ovary in the same individual.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sec. 2, Chung Shan North Road, Taipei 10449, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Ho
authors.forename: Robert Kuo-Kuang
authors.initials: RK
authors.lastname: Lee
authors.forename: Yuh-Ming
authors.initials: YM
authors.lastname: Hwu
authors.forename: Ming-Huei
authors.initials: MH
authors.lastname: Lin
authors.forename: Jin-Tsung
authors.initials: JT
authors.lastname: Su
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004715:Endometriosis / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000494:pharmacology*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D010049:Ovarian Diseases / Q000503:physiopathology* / Q000601:surgery; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology; D010062:Ovulation Induction; D012189:Retrospective Studies
chemical_list: D006062:Gonadotropins