Characteristics of clinical Helicobacter pylori strains from Ecuador.
In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains.
Debets-Ossenkopp
Yvette J
YJ
Department of Clinical Microbiology and Infection Control, Vrije Universiteit Medical Centre, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. yj.debets@vumc.nl
Reyes
Germán
G
Mulder
Janet
J
aan de Stegge
Birgit M
BM
Peters
José T A M
JT
Savelkoul
Paul H M
PH
Tanca
J
J
Peña
Amado S
AS
Vandenbroucke-Grauls
Christina M J E
CM
D024881:Drug Resistance, Bacterial / Q000235:genetics; D004484:Ecuador / Q000453:epidemiology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans