title: Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patients.
abstract: The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.
authors.affiliation: Department of Psychiatry, University of Magdeburg, D-39120 Magdeburg, Germany. Hans-Gert.Bernstein@medizin.uni-magdeburg.de
authors.forename: H-G
authors.initials: HG
authors.lastname: Bernstein
authors.forename: A
authors.initials: A
authors.lastname: Heinemann
authors.forename: D
authors.initials: D
authors.lastname: Krell
authors.forename: C
authors.initials: C
authors.lastname: Mawrin
authors.forename: H
authors.initials: H
authors.lastname: Bielau
authors.forename: P
authors.initials: P
authors.lastname: Danos
authors.forename: S
authors.initials: S
authors.lastname: Diekmann
authors.forename: G
authors.initials: G
authors.lastname: Keilhoff
authors.forename: B
authors.initials: B
authors.lastname: Bogerts
authors.forename: B
authors.initials: B
authors.lastname: Baumann
mesh_terms: D003866:Depressive Disorder / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007031:Hypothalamus / Q000201:enzymology* / Q000473:pathology; D007150:Immunohistochemistry; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D012016:Reference Values; D015398:Signal Transduction / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000201:enzymology* / Q000473:pathology
chemical_list: D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I