[In vivo activity of amoxicillin in a non-toxigenic Corynebacterium diphtheriae rabbit endocarditis experimental model].
The mortality of non-toxigenic Corynebacterium diphtheriae endocarditis is high (27%). One explanation could be tolerance to amoxicillin. The aim of this work was to evaluate in vivo the tolerance phenomenon, in a rabbit endocarditis experimental model. Two strains of non-toxigenic Corynebacterium diphtheriae were compared: a tolerant one and a non-tolerant one. EACH ANIMAL WAS RANDOMLY ASSIGNED TO ONE OF THE FOLLOWING GROUPS: no treatment, continuous infusion of amoxicillin simulating 200 mg/kg/24 h in humans, or fractionated infusion of amoxicillin simulating 66 mg/kg/8 h in humans. Surviving bacteria were counted in vegetations after one or three days of treatment. The 24 h fractionated amoxicillin infusion was more efficacious on the non-tolerant strain than on the tolerant strain. On the tolerant strain, 24 h amoxicillin was more efficacious as a continuous infusion than as a fractionated one.
Grandière-Perez
L
L
Laboratoire d'antibiologie, Faculté de Médecine, 1, rue Gaston-Veil, 44035, Nantes, France.
Jacqueline
C
C
Le Mabecque
V
V
Patey
O
O
Potel
G
G
Bugnon
D
D
Caillon
J
J
D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D003353:Corynebacterium diphtheriae; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D011817:Rabbits; D012016:Reference Values
D000658:Amoxicillin