title: Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.
abstract: We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3'-variable numbers of tandem repeats, the MAO-B-(GT)(n), and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.
authors.affiliation: Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Goudreau
authors.forename: Demetrius M
authors.initials: DM
authors.lastname: Maraganore
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Lesnick
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Singleton
authors.forename: James H
authors.initials: JH
authors.lastname: Bower
authors.forename: John A
authors.initials: JA
authors.lastname: Hardy
authors.forename: Walter A
authors.initials: WA
authors.lastname: Rocca
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D015146:Midwestern United States; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012044:Regression Analysis; D012737:Sex Factors
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase