Papillon-Lefévre syndrome: the response to acitretin.
Papillon-Lefévre syndrome is a rare autosomal recessive disease comprising palmoplantar keratoderma and periodontitis. Palmoplantar keratoderma can be severe, necessitating systemic treatment. Different systemic retinoids were found to be highly efficacious. We describe the successful use of acitretin in one patient who had severe palmoplantar keratoderma, with maintenance of the improvement using topical treatment.
Al-Khenaizan
Sultan
S
Division Of Dermatology/Department of Medicine, King Abdulaziz Medical City, King Fahad National Guard Hospital, Saudi Arabia. salkhenaizan@hotmail.com
D017255:Acitretin / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D010214:Papillon-Lefevre Disease / Q000188:drug therapy* / Q000473:pathology*
D007641:Keratolytic Agents; D017255:Acitretin