title: Serotype C foot-and-mouth disease virus isolates from India belong to a separate so far not described lineage.
abstract: Complete 1D gene sequences of 13 Indian foot-and-mouth disease virus (FMDV) type C field isolates and a vaccine strain (C-Bombay/64) were determined. All the field isolates showed a greater genetic homogeneity (95-100%) among themselves and were 19.7-21.2% divergent from the vaccine strain. In the phylogenetic analysis, the Indian field isolates formed a separate lineage (lineage VII) different from the previously identified six lineages (lineage I-VI) in type C FMDV [J. Virol. 66 (1992) 3557]. The vaccine strain was grouped with European lineage (lineage II). Comparison of the deduced amino acid sequences of antigenic sites A and C of field isolates showed no significant variation from the vaccine strain. One-way serological relationship determined in ELISA showed antigenic closeness of the field isolates with C-Bombay/64.
authors.affiliation: Project Directorate on Foot-and-Mouth Disease, Indian Veterinary Research Institute Campus, Mukteswar, Nainital 263 138, Uttaranchal, India. dhemadri@epatra.com
authors.forename: D
authors.initials: D
authors.lastname: Hemadri
authors.forename: A
authors.initials: A
authors.lastname: Sanyal
authors.forename: C
authors.initials: C
authors.lastname: Tosh
authors.forename: R
authors.initials: R
authors.lastname: Venkataramanan
authors.forename: B
authors.initials: B
authors.lastname: Pattnaik
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics; D001483:Base Sequence; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D029544:Foot-and-Mouth Disease Virus / Q000145:classification* / Q000235:genetics*; D014644:Genetic Variation; D007194:India; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment
chemical_list: D012367:RNA, Viral