Inhibition of protein kinase A activity interferes with long-term, but not short-term, memory of conditioned taste aversions.
The present experiments examined whether inhibition of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) activity interferes with conditioned taste aversion (CTA) memories. Rats were centrally infused with the selective PKA inhibitor Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) before conditioning. Direct infusions of Rp-cAMPS into the amygdala showed no interference with short-term memory but did show significant attenuation of long-term memory and more rapid extinction. Results suggest that PKA activity is involved in the consolidation of long-term memory of CTAs, and that the amygdala may be 1 site that is important for this activity.
Koh
Ming Teng
MT
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Thiele
Todd E
TE
Bernstein
Ilene L
IL
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning; D000242:Cyclic AMP / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D047428:Protein Kinase Inhibitors; D051381:Rats; D020318:Rats, Long-Evans; D013237:Stereoisomerism; D013649:Taste; D013873:Thionucleotides / Q000008:administration & dosage / Q000494:pharmacology
D004791:Enzyme Inhibitors; D047428:Protein Kinase Inhibitors; D013873:Thionucleotides; C016957:adenosine-3',5'-cyclic phosphorothioate; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases