title: Leptospira interrogans binds to the CR3 receptor on mammalian cells.
abstract: Pathogenic leptospires adhere to phagocytes even in the absence of specific antibodies; we demonstrate that the CR3 integrin (known as Mac-1 or CD11b/CD18 receptor), expressed on neutrophils and CHO Mac-1 transfected cells, recognizes and binds leptospires. The I-domain of the molecule seems to be involved in the recognition and data suggest that this occurs via fibronectin absorbed at the Leptospira surface. On the other hand, since N-acetyl-D-glucosamine does not behave as antagonist of the binding, the lectin-like domain of the receptor is not involved in the recognition.
authors.affiliation: Dipartimento di Scienze Biomediche, Spirochete Laboratory, University of Trieste, Italy. cinco@dsbail.units.it
authors.forename: Marina
authors.initials: M
authors.lastname: Cinco
authors.forename: Barbara
authors.initials: B
authors.lastname: Cini
authors.forename: Sra
authors.initials: S
authors.lastname: Perticarari
authors.forename: Gianni
authors.initials: G
authors.lastname: Presani
mesh_terms: D000818:Animals; D016466:CHO Cells; D002478:Cells, Cultured; D006224:Cricetinae; D006801:Humans; D007921:Leptospira interrogans / Q000378:metabolism*; D016177:Macrophage-1 Antigen / Q000235:genetics / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D014162:Transfection
chemical_list: D016177:Macrophage-1 Antigen