Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development.
Extracellular Fatty Acid Binding Protein (Ex-FABP) is a 21 kDa lipocalin, expressed during chicken embryo development in hypertrophic cartilage, in muscle fibres and in blood granulocyte. The protein selectively binds with high affinity fatty acids, preferably long chain unsaturated fatty acids in chondrocyte and myoblast cultures Ex-FABP expression is increased by inflammatory-agents and repressed by anti-inflammatory-agents. In adult cartilage, Ex-FABP is expressed only in pathological conditions such as in dyschondroplastic and osteoarthritic chicken cartilage. We propose that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.
Descalzi Cancedda
Fiorella
F
Istituto Nazionale per la Ricerca sul Cancro, Centro Biotecnologie Avanzate, Genova, Italy. descalzi@cba.unige.it
Dozin
Beatrice
B
Zerega
Barbara
B
Cermelli
Silvia
S
Gentili
Chiara
C
Cancedda
Ranieri
R
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D030161:Avian Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D002642:Chick Embryo / Q000254:growth & development* / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D054835:Lipocalin 1; D054834:Lipocalins
D000893:Anti-Inflammatory Agents; D030161:Avian Proteins; D002352:Carrier Proteins; C066299:Ch21 protein, chicken; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D054835:Lipocalin 1; D054834:Lipocalins