title: 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders.
abstract: Positive association between obsessive compulsive disorder (OCD) and the A-allele of the 5-HT(2A)-receptor promoter polymorphism -1438G/A has recently been reported in adults. We performed an association analysis of this polymorphism in 55 children and adolescents with OCD and in 223 controls consisting of unrelated students. We detected statistically significant differences in genotype (P < 0.05) and allele frequencies (P < 0.05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.
authors.affiliation: Department of Child and Adolescent Psychiatry, Julius-Maximilians-University, Würzburg, Germany. walitza@nervenklinik.uni.wuerzburg.de
authors.forename: S
authors.initials: S
authors.lastname: Walitza
authors.forename: C
authors.initials: C
authors.lastname: Wewetzer
authors.forename: A
authors.initials: A
authors.lastname: Warnke
authors.forename: M
authors.initials: M
authors.lastname: Gerlach
authors.forename: F
authors.initials: F
authors.lastname: Geller
authors.forename: G
authors.initials: G
authors.lastname: Gerber
authors.forename: T
authors.initials: T
authors.lastname: Görg
authors.forename: B
authors.initials: B
authors.lastname: Herpertz-Dahlmann
authors.forename: E
authors.initials: E
authors.lastname: Schulz
authors.forename: H
authors.initials: H
authors.lastname: Remschmidt
authors.forename: J
authors.initials: J
authors.lastname: Hebebrand
authors.forename: A
authors.initials: A
authors.lastname: Hinney
mesh_terms: D000293:Adolescent; D002648:Child; D015897:Comorbidity; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin