Benign intracranial hypertension and thyreostimulin suppression hormonotherapy.
OBJECTIVE
To report a case of benign intracranial hypertension occurring during thyreostimulin suppression hormonotherapy after thyroidectomy for papillary cancer.


METHODS
Interventional case report.


METHODS
A 45-year-old woman underwent total thyroidectomy for a 7-mm papillary cancer. Seventeen years later, she experienced headache, dizziness, irritability, sensation of full head, and blurred vision of the right eye while being treated with a mix of L thyroxin (LT4) and liothyronin (LT3). Ophthalmological data (including the presence of papilledema), cerebroorbital magnetic resonance imaging, and lumbar pressure evaluation confirmed benign intracranial hypertension.


RESULTS
Substitutive hormonotherapy was decreased under specialized surveillance, permitting remission of benign intracranial hypertension symptoms and papilledema.


CONCLUSIONS
Benign intracranial hypertension is usually difficult to cure, and its association with thyroid hormonotherapy is rare. In our patient, tapering LT4 and withdrawal of LT3 until a euthyroidal state was obtained resulted in successful treatment of benign intracranial hypertension.
Serratrice
Jacques
J
Service de Médecine Interne, Hôpital de la Timone, Marseille, France.
Granel
Brigitte
B
Conrath
John
J
Dufour
Henri
H
Disdier
Patrick
P
Henry
Jean François
JF
Weiller
Pierre-Jean
PJ
D000231:Adenocarcinoma, Papillary / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D006023:Glycoproteins / Q000037:antagonists & inhibitors*; D006801:Humans; D008875:Middle Aged; D010211:Papilledema / Q000139:chemically induced; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy; D013974:Thyroxine / Q000009:adverse effects*; D014284:Triiodothyronine / Q000009:adverse effects*
D006023:Glycoproteins; C458339:thyrostimulin; D014284:Triiodothyronine; D013974:Thyroxine