Pathological aspects of apoptosis in severe sepsis and shock?
Today, despite the application of contemporary operative/pharmacological approaches in the treatment of the critically ill trauma/surgery patient, we are still faced with a high incidence of patients who develop sepsis and subsequent multiple organ failure. This review attempts to summarize data gathered over the last few years, from both experimental and patient settings, that not only documents the presence of apoptosis, but begins to define its contribution to the pathology of sepsis and shock, which in turn precipitate organ injury/damage.
Ayala
Alfred
A
Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, Aldrich 227, 593 Eddy Street, Providence, RI 02903, USA. aayala@lifespan.org
Lomas
Joanne L
JL
Grutkoski
Patricia S
PS
Chung
Chun-Shiang
CS
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology; D010586:Phagocytes / Q000473:pathology; D018805:Sepsis / Q000473:pathology* / Q000628:therapy; D012769:Shock / Q000473:pathology* / Q000628:therapy; D014947:Wounds and Injuries / Q000473:pathology