Diuretic effect of sodium artesunate in patients with malaria.
Previously, we described a direct inhibitory effect of sodium artesunate on sodium chloride transport in the thick ascending limb of Henle's loop, indicating that artesunate acts as a diuretic agent. Here we present 2 cases of falciparum malaria treated with 4 intravenous 60-mg doses of sodium artesunate. Neither diuretics nor vasoactive drugs were administered. A rise in diuresis (6 L/24 hours) was accompanied by an increase in natriuresis, and both declined at the end of the treatment. This diuretic effect has not been reported previously in patients and may modify the course of renal failure and respiratory distress syndrome, both of which complicate severe malaria.
Seguro
Antonio Carlos
AC
Instituto de Infectologia Emílio Ribas, Laboratório de Investigação Médica, LIM-12, Nefrologia, Faculdade de Medicina USP, São Paulo, Brazil. trulu@usp.br
Campos
Silvia Bernardete
SB
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use*; D037621:Artemisinins / Q000009:adverse effects* / Q000627:therapeutic use*; D000077332:Artesunate; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy*; D016780:Malaria, Vivax / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D051437:Renal Insufficiency / Q000150:complications / Q000503:physiopathology; D012717:Sesquiterpenes / Q000009:adverse effects* / Q000627:therapeutic use*
D000962:Antimalarials; D037621:Artemisinins; D004232:Diuretics; D012717:Sesquiterpenes; D000077332:Artesunate