Unravelling the signal-transduction network in B lymphocytes.
The Alliance for Cellular Signaling has chosen the mouse B lymphocyte as a model system to understand basic principles that govern cellular signalling. Progress to that end has focused initially on establishing a reproducible experimental cell system and characterizing essential signalling responses. Although unravelling this complex network will take years, findings revealed in the interim will prove immensely useful to the scientific community at large.
Sambrano
Gilberto R
GR
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA. sambrano@cmp.ucsf.edu
Chandy
Grischa
G
Choi
Sangdun
S
Decamp
Dianne
D
Hsueh
Robert
R
Lin
Keng-Mean
KM
Mock
Dennis
D
O'Rourke
Nancy
N
Roach
Tamara
T
Shu
Hongjun
H
Sinkovits
Bob
B
Verghese
Mary
M
Bourne
Henry
H
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D020869:Gene Expression Profiling; D051379:Mice; D008954:Models, Biological; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D011485:Protein Binding; D012106:Research / Q000639:trends; D012107:Research Design; D015398:Signal Transduction
D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate