[The effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival].
OBJECTIVE
To observe the effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival.


METHODS
Male New-Zealand rabbits weighting 2.0-2.5 kg were used in this study. The experimental model used a prefabricated neck flap, supplied by the transferred and implanted central vascular bundle of the ear. 9 micrograms bFGF and 0.2 ml of normal saline was instilled in the vascular pedicle of the experimental and the control group respectively. After 1, 2, 3 weeks of operation, the neovascularization was studied by confocal laser scanning microscope (CLSM) and flap survival was observed.


RESULTS
The neovascularization and survival of the prefabricated flap was different in the experimental and the control groups. The experimental group was better than the control group.


CONCLUSIONS
bFGF treatment improved sprouting of the implanted vessel and the prefabricated flap survival.
Wang
Xukai
X
Department of Plastic Surgery, First Hospital, China Medical University, Shenyang 110001, China.
Yan
Dong
D
Liu
Yongquan
Y
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018613:Microscopy, Confocal; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011817:Rabbits; D013524:Surgical Flaps / Q000098:blood supply / Q000502:physiology*; D013997:Time Factors
D016222:Fibroblast Growth Factor 2