title: Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants.
abstract: Clinicopathologic data from 285 autopsies were analyzed. The decedents were long-standing participants in the Honolulu-Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed the prevalence at death of four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), Alzheimer lesions (12%), hippocampal sclerosis (5%), cortical Lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). Definite or probable dementia had been identified in 118 of the decedents. The proportions of men in each subset identified as demented were (in the same order) 57%, 53%, 79%, 57%, 76%, and 25%. In this autopsied panel of older Japanese-American men, the importance of microvascular lesions as a likely explanation for dementia was nearly equal to that of Alzheimer lesions. The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction.
authors.affiliation: Kuakini Medical Center, 846 S Hotel Street, Honolulu, HI 96813, USA. White@phri.Hawaii-health.com
authors.forename: Lon
authors.initials: L
authors.lastname: White
authors.forename: Helen
authors.initials: H
authors.lastname: Petrovitch
authors.forename: John
authors.initials: J
authors.lastname: Hardman
authors.forename: James
authors.initials: J
authors.lastname: Nelson
authors.forename: Daron G
authors.initials: DG
authors.lastname: Davis
authors.forename: G Webster
authors.initials: GW
authors.lastname: Ross
authors.forename: Kamal
authors.initials: K
authors.lastname: Masaki
authors.forename: Lenore
authors.initials: L
authors.lastname: Launer
authors.forename: William R
authors.initials: WR
authors.lastname: Markesbery
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D019980:Amoxicillin-Potassium Clavulanate Combination; D001208:Asia / Q000208:ethnology; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003704:Dementia / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000473:pathology*; D011446:Prospective Studies
chemical_list: D019980:Amoxicillin-Potassium Clavulanate Combination