title: Activation of the p38 MAPK and ERK1/2 pathways is required for Fas-induced IL-8 production in colonic epithelial cells.
abstract: This paper aims to examine the contribution of all three of the MAP kinase signaling pathways to Fas-induced IL-8 up-regulation in HT29 colon epithelial cells.
authors.affiliation: Department of Medicine, National University of Ireland, Cork, Ireland. ob_darren@hotmail.com
authors.forename: Darren
authors.initials: D
authors.lastname: O'Brien
authors.forename: Terry
authors.initials: T
authors.lastname: O'Connor
authors.forename: Fergus
authors.initials: F
authors.lastname: Shanahan
authors.forename: Joe
authors.initials: J
authors.lastname: O'Connell
mesh_terms: D015703:Antigens, CD / Q000502:physiology; D001483:Base Sequence; D003106:Colon; D017931:DNA Primers; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D019073:HT29 Cells; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D007413:Intestinal Mucosa / Q000276:immunology*; D007700:Kinetics; D020935:MAP Kinase Signaling System / Q000276:immunology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D019014:fas Receptor / Q000502:physiology*; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D015703:Antigens, CD; D017931:DNA Primers; D004791:Enzyme Inhibitors; D005419:Flavonoids; D016209:Interleukin-8; D019014:fas Receptor; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one