title: Synthesis of C-3' methyl taxotere (docetaxel).
abstract: Protected (3R,4S)-N-Boc-3-hydroxy-4-methyl-4-phenylazetidin-2-one has been synthesized stereoselectively and used to esterify protected 10-desacetylbaccatin III to give, following removal of the protecting groups, novel C-3' methyl taxotere (docetaxel).
authors.affiliation: LEDSS, Université Joseph Fourier, Chimie Recherche, BP 53X, 38041 Grenoble Cedex, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lucatelli
authors.forename: Florian
authors.initials: F
authors.lastname: Viton
authors.forename: Yves
authors.initials: Y
authors.lastname: Gimbert
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene
mesh_terms: D020650:Combinatorial Chemistry Techniques; D000077143:Docetaxel; D004951:Esterification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D043823:Taxoids
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel