Inhalation exposures to acrylamide in biomedical laboratories.
This study evaluated airborne acrylamide exposures experienced by laboratory personnel using either crystalline or commercially available solutions of acrylamide to make polyacrylamide gels. Exposures were monitored for a short-term (15-min) sampling period, during the weighing of the crystalline acrylamide or the removal of the acrylamide solution from its original container, and a long-term period, during which a sample was collected for as long as the subject was potentially exposed to acrylamide. Mean air concentrations for the 15-min exposures were 7.20 +/- 5.64 micrograms/m3 and 5.81 +/- 4.53 micrograms/m3 for the users of crystalline and solution acrylamide, respectively, although this difference was not statistically significant (p > 0.05). Mean concentrations for the long-term exposures were 12.77 +/- 24.20 micrograms/m3 for workers employing crystalline acrylamide and 4.22 +/- 7.05 micrograms/m3 for personnel using acrylamide solutions. This difference was also not statistically significant. Although the results indicate that the research laboratory personnel were generally exposed to measurable concentrations of acrylamide, with several subjects exposed to elevated levels, the calculated 8-hour time-weighted average exposures were below current occupational exposure limits. However, because the neurotoxic effects of acrylamide are cumulative and it is a suspected carcinogen, all exposures should be kept as low as reasonably achievable.
Pantusa
Victor P
VP
Texas A&M University System Health Science Center, Institute of Biosciences and Technology, 2121 W. Holcombe Blvd., Houston, TX 77030-3303, USA.
Stock
Thomas H
TH
Morandi
Maria T
MT
Harrist
Ronald B
RB
Afshar
Masoud
M
D020106:Acrylamide / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D020811:Biomedical Technology; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D007753:Laboratories
D000395:Air Pollutants, Occupational; D020106:Acrylamide