Current trends in the treatment of upper gastrointestinal disease.
The past 25 years have seen an amazing improvement in the treatment and understanding of acid-related disorders. In particular, the introduction of selective histamine receptor antagonists and proton pump inhibitors has made the medical control of acid secretion an effective means of therapy. The demonstration that infection with Helicobacter pylori is responsible for most cases of peptic ulcer disease resulted in another major improvement in therapy in these areas as a result of the eradication of the organism. Research continues in an attempt to find improved means of acid control and better methods for the eradication of H. pylori based on unique proteins expressed by the organism to resist gastric acidity.
Sachs
George
G
Geffen School of Medicine at UCLA and GWLA Health Center, Los Angeles, USA.
Shin
Jai Moo
JM
Vagin
Olga
O
Munson
Keith
K
Weeks
David
D
Scott
David R
DR
Voland
Petra
P
D000863:Antacids / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D005770:Gastrointestinal Neoplasms / Q000517:prevention & control; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D054328:Proton Pump Inhibitors
D000863:Antacids; D054328:Proton Pump Inhibitors