Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis.
The combined expression of the inflammatory mediators, matrix metalloproteinases (MMPs), soluble form of intracellular adhesion molecule ICAM-1 (sICAM-1) and interleukin (IL)-8, was evaluated in children infected with bacterial or viral meningitis. MMP-2 and IL-8 were detected in all CSF samples and were enhanced in both bacterial and viral infected samples, compared to those from control children. The expression of MMP-9 as well as sICAM-1 was not detected in control CSF while observed in viral infected and further elevated in bacterial infected samples. This pilot study supports a role for MMPs, IL-8 and sICAM in infectious meningitis and suggests further research to determine their possible use as biomarkers for various forms of meningeal infection as well as the use of their specific antagonists as potential therapeutic agents for central nervous system (CNS) inflammatory processes.
Shapiro
Sarah
S
Immunology Research Unit, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa, 34362 Israel.
Miller
Ariel
A
Lahat
Nitza
N
Sobel
Esther
E
Lerner
Aaron
A
D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D018093:Gelatinases / Q000134:cerebrospinal fluid; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000134:cerebrospinal fluid*; D016209:Interleukin-8 / Q000134:cerebrospinal fluid*; D020778:Matrix Metalloproteinase 2 / Q000134:cerebrospinal fluid; D020784:Matrix Metalloproteinase 8 / Q000134:cerebrospinal fluid; D020780:Matrix Metalloproteinase 9 / Q000134:cerebrospinal fluid; D020782:Matrix Metalloproteinases / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000201:enzymology / Q000276:immunology; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000201:enzymology / Q000276:immunology; D012016:Reference Values
D015415:Biomarkers; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1; D018093:Gelatinases; D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9