Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: the role of glucocorticoids.
The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.
Priego
T
T
Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain.
Ibañez De Cáceres
I
I
Martín
A I
AI
Villanúa
M A
MA
López-Calderón
A
A
D000315:Adrenalectomy; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000235:genetics / Q000503:physiopathology*
D018972:Insulin-Like Growth Factor Binding Protein 3; D008070:Lipopolysaccharides