Hepatoprotective pyrrole derivatives of Lycium chinense fruits.
As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively).
Chin
Young-Won
YW
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, South Korea.
Lim
Song-Won
SW
Kim
Seok-Ho
SH
Shin
Dong-Yun
DY
Suh
Young-Ger
YG
Kim
Yang-Bae
YB
Kim
Young Choong
YC
Kim
Jinwoong
J
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D005638:Fruit / Q000737:chemistry; D022781:Hepatocytes / Q000187:drug effects*; D008107:Liver Diseases / Q000517:prevention & control; D032305:Lycium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification*; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D020011:Protective Agents; D011758:Pyrroles; D002251:Carbon Tetrachloride