title: Metabolic and immunological effects of antiretroviral agents in healthy individuals receiving post-exposure prophylaxis.
abstract: We have assessed metabolic and immunological effects of a nelfinavir-containing regimen in healthy HIV-1-uninfected individuals receiving post-exposure prophylaxis. Our data suggest that this regimen is well tolerated and did not modify the lipid or hepatic profiles. This antiretroviral regimen seems to have no effect on lymphocyte T cell subsets, however, it could have an immune-modulator role, inducing an increase in the proliferative responses to mitogens.
authors.affiliation: Infectious Diseases Unit, University of Barcelona, Barcelona, Spain. fgarcia@medicina.ub.es
authors.forename: Felipe
authors.initials: F
authors.lastname: Garcia
authors.forename: Montserrat
authors.initials: M
authors.lastname: Plana
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mestre
authors.forename: Anna
authors.initials: A
authors.lastname: Cruceta
authors.forename: Esteban
authors.initials: E
authors.lastname: Martinez
authors.forename: José M
authors.initials: JM
authors.lastname: Miró
authors.forename: Josep
authors.initials: J
authors.lastname: Mallolas
authors.forename: Montserrat
authors.initials: M
authors.lastname: Tuset
authors.forename: Tomas
authors.initials: T
authors.lastname: Pumorola
authors.forename: Teresa
authors.initials: T
authors.lastname: Gallart
authors.forename: José M
authors.initials: JM
authors.lastname: Gatell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents