title: Immune responses to Neospora caninum and prospects for vaccination.
abstract: Developing an effective vaccine against neosporosis presents several interesting challenges. The parasite is spread efficiently from mother to foetus over several generations, and naturally infected cattle do not appear to develop adequate protective immunity. Modulation of the immune response during pregnancy favours parasite survival and multiplication. However, induction of pro-inflammatory responses that are thought to be protective against Neospora caninum would be detrimental to the pregnancy. So, is vaccination a feasible option to control the disease? This article discusses some of these issues and reports on the progress towards a vaccine for neosporosis.
authors.affiliation: Dept of Parasitology, Moredun Research Institute, Pentlands Science Park, Edinburgh, UK. Innel@mri.sari.ac.uk
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Innes
authors.forename: Aurélie G
authors.initials: AG
authors.lastname: Andrianarivo
authors.forename: Camilla
authors.initials: C
authors.lastname: Björkman
authors.forename: Diana J L
authors.initials: DJ
authors.lastname: Williams
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Conrad
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000469:parasitology; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000635:transmission / Q000662:veterinary*; D005260:Female; D006790:Host-Parasite Interactions; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary*; D018688:Neospora / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000662:veterinary; D016052:Protozoan Vaccines / Q000276:immunology* / Q000592:standards
chemical_list: D016052:Protozoan Vaccines