Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: a pilot study.
We observed less severe symptoms in patients with chronic idiopathic thrombocytopenic purpura (ITP) than in patients with acute ITP with similar platelet counts. Thrombopoietin (TPO), soluble P-selectin, soluble P-selectin per platelet, and interleukin 6 (IL-6) were evaluated in children with ITP before treatment in 16 acute and 22 chronic cases and after treatment in 10 acute and chronic cases who received mega-dose methylprednisolone. The levels of IL-6, soluble P-selectin, soluble P-selectin per platelet, and platelet count were similar in acute and chronic ITP (P > 0.05) but TPO in acute ITP was higher than that of the patients with chronic ITP (P < 0.05). The posttreatment IL-6 and TPO declined (P < 0.05), but soluble P-selectin and platelet count increased (P < 0.05). Posttreatment soluble P-selectin per platelet levels were higher than the normal values (P < 0.05). These results suggest that IL-6, soluble P-selectin, and soluble P-selectin per platelet are not responsible for the milder symptoms in chronic than in acute ITP. Mega-dose methylprednisolone seems to keep the soluble P-selectin levels elevated.
Olcay
Lale
L
Ankara Oncology Hospital, Demetevler, Ankara, Turkey. laleolcay@hotmail.com
Yenicesu
Idil
I
Yetgin
Sevgi
S
D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008775:Methylprednisolone / Q000627:therapeutic use*; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000188:drug therapy*; D012016:Reference Values; D013926:Thrombopoietin / Q000097:blood*
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D019007:P-Selectin; D013926:Thrombopoietin; D008775:Methylprednisolone