Monoclonal antibodies in immune and inflammatory diseases.
The era of monoclonal antibody-based therapeutics has arrived. Monoclonal antibodies of high quality targeting almost any antigen can now be engineered and manufactured in large quantities. In the clinic, monoclonal antibodies are proving to be safe and effective for the treatment of a wide range of diseases including rheumatoid arthritis, Crohn's disease, spondyloarthropathies, psoriasis and allograft rejection.
Andreakos
Evangelos
E
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, W6 8LH, London, UK. evangelos.andreakos@ic.ac.uk
Taylor
Peter C
PC
Feldmann
Marc
M
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000628:therapy*; D001327:Autoimmune Diseases / Q000628:therapy; D020274:Autoimmune Diseases of the Nervous System; D002648:Child; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000628:therapy*; D017277:Drug Approval; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods; D007249:Inflammation / Q000628:therapy*
D000911:Antibodies, Monoclonal