title: The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury.
abstract: Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Sequential waves of chemokine expression play a central role in regulating graft injury through the recruitment of phagocytes shortly after transplantation and activated lymphocytes and phagocytes in the weeks and years following transplantation. This review focuses on recent studies demonstrating the role of chemokines in transplantation.
authors.affiliation: Department of Immunology, Division of Experimental Therapeutics, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.
authors.forename: Mark E
authors.initials: ME
authors.lastname: DeVries
authors.forename: Karoline A
authors.initials: KA
authors.lastname: Hosiawa
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Cameron
authors.forename: Steven E
authors.initials: SE
authors.lastname: Bosinger
authors.forename: Desmond
authors.initials: D
authors.lastname: Persad
authors.forename: Alyson A
authors.initials: AA
authors.lastname: Kelvin
authors.forename: Jeff C
authors.initials: JC
authors.lastname: Coombs
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Robert
authors.initials: R
authors.lastname: Zhong
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cameron
authors.forename: David J
authors.initials: DJ
authors.lastname: Kelvin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D018925:Chemokines / Q000276:immunology*; D002908:Chronic Disease; D020869:Gene Expression Profiling; D006084:Graft Rejection / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*; D014181:Transplantation Immunology; D014764:Viral Proteins / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D018925:Chemokines; D007519:Isoantigens; D019707:Receptors, Chemokine; D014764:Viral Proteins