Ethical considerations in the use of lentiviral vectors for genetic transfer.
This chapter will outline the various concerns which have been raised in scientific, bioethics, and lay communities about the use of lentiviral vectors for purposes of gene therapy. Many of these concerns are ranged around gene therapy itself; others are concerns particular to using this sort of vector for genetic modification of human cells. These concerns are outlined within the chapter, and arguments are given in favor and against various approaches to these concerns. Lastly, it is noted throughout that at this stage of research into gene therapy, the most practical approach to these dilemmas is to maintain awareness of the ethical problems and provide information to those concerned with all aspects of the development of this set of technologies.
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Center for Bioethics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
D000818:Animals; D018014:Gene Transfer Techniques / Q000941:ethics*; D015316:Genetic Therapy / Q000941:ethics* / Q000592:standards; D005822:Genetic Vectors / Q000592:standards*; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D012449:Safety