Efficient, racemization-free peptide coupling of N-alkyl amino acids by using amino acid chlorides generated in situ--total syntheses of the cyclopeptides cyclosporin O and omphalotin A.
Sewald
Norbert
N
Organische und Bioorganische Chemie, Universität Bielefeld, Postfach 100131, 33501 Bielefeld, Germany. norbert.sewald@uni-bielefeld.de
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D003524:Cyclosporins / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation
D000596:Amino Acids; D002712:Chlorides; D003524:Cyclosporins; D010456:Peptides, Cyclic; C412021:cyclosporin O; C468746:omphalotin A