[Acetaminophen-induced hypothermia, an AIDS related side-effect? About 4 cases].
Hypothermia is an uncommon side effect of acetaminophen. We report 4 cases of HIV-infected patients who developed hypothermia after intravenous injection of propacetamol (the parenteral formulation of acetaminophen). The mechanism of this hypothermia is unknown. AIDS-induced changes in the metabolism of acetaminophen, could be an explanation. AIDS-associated opportunistic diseases may account for part of the mechanism. These hypothermias occur within 6 hours after the injection, are well tolerated and regress spontaneously.
Denes
Eric
E
Service de Maladies Infectieuses et Tropicales, CHU Dupuytren, 87042 Limoges, France. eric.denes@unilim.fr
Amaniou
Monique
M
Rogez
Jean-Philippe
JP
Weinbreck
Pierre
P
Merle
Louis
L
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen