title: Steroidal ureas as enantioselective receptors for an N-acetyl alpha-amino carboxylate.
abstract: [reaction: see text] Cholic acid has been elaborated into three regioisomeric bis-carbamoylureas, which have been investigated as enantioselective receptors for N-acetyl phenylalanine. L/D selectivities, peaking at 5:1, have been determined by a sensitive and rapid MS-based extraction method that should be generalizable to related systems.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.
authors.forename: Laura
authors.initials: L
authors.lastname: Siracusa
authors.forename: Fionn M
authors.initials: FM
authors.lastname: Hurley
authors.forename: Stefan
authors.initials: S
authors.lastname: Dresen
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Lawless
authors.forename: M Nieves
authors.initials: MN
authors.lastname: Pérez-Payán
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Davis
mesh_terms: D019826:Cholic Acid / Q000737:chemistry*; D018716:Molecular Mimicry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D017459:Receptors, Amino Acid / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D017459:Receptors, Amino Acid; D012997:Solvents; D013256:Steroids; D010649:Phenylalanine; D014508:Urea; D019826:Cholic Acid; C044228:N-acetylphenylalanine