SPPS of protected peptidyl aminoalkyl amides.
Monophthaloyl diamines derived from naturally occurring amino acids were attached through their free amino functions to resins of the trityl type. The phthaloyl groups were removed by hydrazinolysis, and peptide chains were assembled using Fmoc/tBu-amino acids on the liberated amino functions. The peptidyl aminoalkyl amides obtained were cleaved from the resins by mild acidolysis, with the tBu-side chain protection remaining intact.
Karavoltsos
Manolis
M
Department of Chemistry, University of Patras, Patras, Greece.
Mourtas
Spyros
S
Gatos
Dimitrios
D
Barlos
Kleomenis
K
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
D000577:Amides; D010455:Peptides