Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.
[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.
Shin
Youseung
Y
Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
Choy
Nakyen
N
Turner
Tiffany R
TR
Balachandran
Raghavan
R
Madiraju
Charitha
C
Day
Billy W
BW
Curran
Dennis P
DP
D000473:Alkanes; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002219:Carbamates; D005260:Female; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D018942:Macrolides; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D011753:Pyrones; D014407:Tumor Cells, Cultured
D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D018942:Macrolides; D011753:Pyrones; C470814:dictyostatin; C071229:discodermolide