title: Stereoselective transformation of indole diazabicyclo[3.2.2]nonedione to azepinoindole.
abstract: [reaction: see text] The synthesis of an indole diazabicyclo[3.2.2]nonedione derivative was achieved in a few steps starting from L-tryptophan. Reduction with borane-THF complex leads to fragmentation of the bicycle and the stereoselective formation of an azepinoindole derivative was observed.
authors.affiliation: Novartis Pharma AG, Core Technology, Combinatorial Chemistry Unit, WSJ-507.7.04 Lichtstrasse 35, CH-4056 Basel, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Orain
authors.forename: Régis
authors.initials: R
authors.lastname: Denay
authors.forename: Guido
authors.initials: G
authors.lastname: Koch
authors.forename: Rudolf
authors.initials: R
authors.lastname: Giger