Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences.
Histone mRNA metabolism is tightly coupled to cell cycle progression and to rates of DNA synthesis. The recent identification of several novel proteins involved in histone gene transcription and pre-mRNA processing has shed light on the variety of mechanisms cells employ to achieve this coupling.
Marzluff
William F
WF
Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA.
Duronio
Robert J
RJ
D000818:Animals; D005075:Biological Evolution; D002453:Cell Cycle; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000096:biosynthesis / Q000235:genetics*; D008957:Models, Genetic; D009866:Oogenesis; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
D006657:Histones; D012322:RNA Precursors; D012333:RNA, Messenger