title: Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
abstract: Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation.
authors.affiliation: Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark. jpm@novonordisk.com
authors.forename: John P
authors.initials: JP
authors.lastname: Mogensen
authors.forename: Lone
authors.initials: L
authors.lastname: Jeppesen
authors.forename: Paul S
authors.initials: PS
authors.lastname: Bury
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pettersson
authors.forename: Jan
authors.initials: J
authors.lastname: Fleckner
authors.forename: Jan
authors.initials: J
authors.lastname: Nehlin
authors.forename: Klaus S
authors.initials: KS
authors.lastname: Frederiksen
authors.forename: Tatjana
authors.initials: T
authors.lastname: Albrektsen
authors.forename: Nanni
authors.initials: N
authors.lastname: Din
authors.forename: Steen B
authors.initials: SB
authors.lastname: Mortensen
authors.forename: L Anders
authors.initials: LA
authors.lastname: Svensson
authors.forename: Karsten
authors.initials: K
authors.lastname: Wassermann
authors.forename: Erik M
authors.initials: EM
authors.lastname: Wulff
authors.forename: Lars
authors.initials: L
authors.lastname: Ynddal
authors.forename: Per
authors.initials: P
authors.lastname: Sauerberg
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000737:chemistry / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors