Studies on the synthesis and anti-Osteoporosis of estrogen-GHRPs linkers.
The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the anti-osteoporosis potency for estradiol, estrone, TyrGlyGlyPheLeuOH and TyrGlyGlyPheLeuNH(2) may be totally enhanced each other via the corresponding linkers.
Wang
Chao
C
College of Pharmaceutical Sciences, Peking University, Beijing 100083, P R China.
Cui
Weina
W
Zhao
Ming
M
Yang
Jian
J
Peng
Shiqi
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000097:blood; D003432:Cross-Linking Reagents; D004967:Estrogens / Q000737:chemistry* / Q000494:pharmacology; D005269:Femur / Q000737:chemistry / Q000187:drug effects; D013007:Growth Hormone-Releasing Hormone; D006728:Hormones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010024:Osteoporosis / Q000188:drug therapy*; D010758:Phosphorus / Q000032:analysis; D051381:Rats
D003432:Cross-Linking Reagents; D004967:Estrogens; D006728:Hormones; D009842:Oligopeptides; D010758:Phosphorus; D013007:Growth Hormone-Releasing Hormone; D002118:Calcium