title: [Amyloidosis and aging].
abstract: Amyloidosis is a heterogeneous group of extracellular protein deposition diseases. Age-related amyloidosis may be systemic or localized. The systemic forms include associated-myeloma AL amyloidosis and senile systemic amyloidosis which is the only clear-cut systemic form related to age and derived from normal transthyretin. In localized amyloidosis, the fibril protein precursors are synthesized in the tissue involved by the amyloid. In most cases, localized age-related amyloidosis does not appear to cause clinical disease with the exception of amyloid associated with Alzeihmer's disease and type 2 diabetes mellitus. The significance of aortic amyloidosis, amyloidosis of seminal vesicles, amyloid of the endocrine glands, and articular amyloidosis remains unknown.
authors.affiliation: Service de Rhumatologie, Centre Hospitalier Universitaire, 29609 Brest Cedex, France.
authors.forename: Nagi
authors.initials: N
authors.lastname: Mimassi
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
authors.forename: Yvon-Louis
authors.initials: YL
authors.lastname: Pennec
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000686:Amyloidosis / Q000145:classification* / Q000175:diagnosis; D001057:Apolipoproteins E / Q000032:analysis; D016657:Cerebral Amyloid Angiopathy / Q000145:classification / Q000175:diagnosis; D028243:Cerebral Amyloid Angiopathy, Familial / Q000175:diagnosis; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D000683:Serum Amyloid P-Component / Q000032:analysis
chemical_list: D001057:Apolipoproteins E; D006025:Glycosaminoglycans; D000683:Serum Amyloid P-Component