title: Hepatoprotective pyrrole derivatives of Lycium chinense fruits.
abstract: As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively).
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, South Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Song-Won
authors.initials: SW
authors.lastname: Lim
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Shin
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Yang-Bae
authors.initials: YB
authors.lastname: Kim
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D005638:Fruit / Q000737:chemistry; D022781:Hepatocytes / Q000187:drug effects*; D008107:Liver Diseases / Q000517:prevention & control; D032305:Lycium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification*; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D020011:Protective Agents; D011758:Pyrroles; D002251:Carbon Tetrachloride