title: Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation.
abstract: OBJECTIVE
  To illustrate the safety and efficacy of fomepizole in a case of methanol poisoning with initial visual impairment.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 60-year-old man was admitted with blurred vision and changes in color perception 18 hours after ingesting 100 ml methanol. Fomepizole was chosen for antidotal therapy in combination with hemodialysis. Flash electroretinogram (fERG) and flash visual evoked potentials (fVEPs) examinations were obtained at the bedside 2 hours after admission and on days 1 and 8. The monocular pattern-reversal visual evoked potentials (pVEPs) were investigated on days 1 and 8.
  
  
  RESULTS
  A complete reversal of visual impairment was achieved within 20 hours. An abnormal b-wave amplitude and an increased peak III latency at VEPs were present on admission and recovered within 24 hours.
  
  
  CONCLUSIONS
  Fomepizole appeared safe and effective for a patient who had severe methanol poisoning presenting with visual impairment.
authors.affiliation: Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Essama Mbia
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Guérit
authors.forename: Vincent
authors.initials: V
authors.lastname: Haufroid
authors.forename: Philippe
authors.initials: P
authors.lastname: Hantson
mesh_terms: D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors; D000931:Antidotes / Q000627:therapeutic use*; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D000077604:Fomepizole; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008875:Middle Aged; D011041:Poisoning / Q000188:drug therapy; D011720:Pyrazoles / Q000627:therapeutic use*; D006435:Renal Dialysis; D012449:Safety; D014786:Vision Disorders / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D000426:Alcohol Dehydrogenase; D000432:Methanol