[Poisoning by chromium and its long lasting detoxication].
Long lasting influence of cumulated Cr provide irreversible damages of vascular walls, organs and their systems. During long lasting treatment most of Cr is removed during the first 20 days through bileric tract and at the same time through the renal tract the Cr amounts decreases because chromium-d-penicilamin complex in hepatocytes induces synthesis of specific chromium-d-penicilamin binding labile protein and they are removed with bile. The levels of essential microelements (Cu and Zn) are maintained at the level of the physiological tolerance during treatment. Cr removes very slowly (about a year) from human body, and after treatment patients health do not improve because Cr-inducted damages of vascullars, organs and their systems are not recovered. The treatment must be evaluated continuously by controlling concentrations' of Cr, Cu, Zn and other microelements in the blood, plasma and urine by electrothermal atomic absorbtion spectrophotometry methods.
Ryselis
Stanislovas
S
Kauno medicinos universiteto Biomedicininiu tyrimu institutas, Eiveniu 4, 3007 Kaunas.
Abdrachmanovas
Olegas
O
Vitkuviene
Birute
B
Naginiene
Rima
R
D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002857:Chromium / Q000506:poisoning*; D004050:Ditiocarb / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy; D011247:Pregnancy; D013054:Spectrophotometry, Atomic; D013997:Time Factors
D002614:Chelating Agents; D002857:Chromium; D004050:Ditiocarb; D010396:Penicillamine; C039353:dihydroxyethyldithiocarbamate