title: In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease.
abstract: OBJECTIVE
  Interleukin (IL)-6-mediated inflammation is involved in cardiovascular disease (CVD). We assessed IL-6 levels and the -174G>C genotype in a case-control study of men and women (average age 73 years) within the Cardiovascular Health Study.
  
  
  RESULTS
  Cases included incident angina, myocardial infarction (MI), and stroke (5-year follow-up), prevalent MI, and MRI-detectable infarcts. A control group and a group free of subclinical CVD were used for comparison. The -174C allele was associated with higher C-reactive protein (11% higher, P=0.02), fibrinogen (3% higher, P=0.02), and IL-6 (5% higher; P=0.16). IL-6 was associated with increased atherosclerosis when the control group was compared with the group free of subclinical CVD. No further association with CVD events was found when case groups were compared with the control group. Compared with its absence, presence of the -174C allele was associated with risk of MRI infarcts (odds ratio 1.5).
  
  
  CONCLUSIONS
  IL-6 levels differentiated those with subclinical CVD from those without. Although the -174C allele was not associated with incident events, associations of the genotype with inflammation and MRI infarcts, combined with the plasma IL-6 results, suggest that IL-6 may chronically predispose an individual to develop atherosclerosis.
authors.affiliation: Department of Pathology, College of Medicine, University of Vermont, Burlington, USA.
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Jenny
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Ogg
authors.forename: Le Ahn
authors.initials: le A
authors.lastname: Luong
authors.forename: Lewis H
authors.initials: LH
authors.lastname: Kuller
authors.forename: Alice M
authors.initials: AM
authors.lastname: Arnold
authors.forename: A Richey
authors.initials: AR
authors.lastname: Sharrett
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000235:genetics*; D016022:Case-Control Studies; D003596:Cytosine / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006147:Guanine / Q000378:metabolism*; D006306:Health Surveys; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics*; D016014:Linear Models; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D011401:Promoter Regions, Genetic / Q000502:physiology
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D006147:Guanine; D003596:Cytosine