[Changes in bone mineral density in rheumatoid arthritis].
Rheumatoid arthritis (RA) is one of the causes of secondary osteoporosis. One hundred eighty eight patients with RA (27 males and 161 females) were examined; the historical, clinical data and bone mineral mass of the spine and of the hip were evaluated. Osteoporosis was found more frequently in the spine than in the hip (27.7% and 17.9% respectively, p = 0.04). Bone mineral density (BMD) in the spine was less in women than in men (p = 0.04). The number of swollen joints, the mean of erythrocyte sedimentation rate (ESR) and rheumatoid factor (as indicators of inflammation) are correlated significantly with BMD of the hip. The age, hypogonadism and RA specific factors such as the duration and stage of the disease, and the long use of glucocorticosteroids were associated with osteoporosis. The relation between osteoporosis and history of a prior fracture in patients or in closest relatives, low weight, smoking, and RA specific factor such as the mean daily dose of glucocorticosteroids was not significant.
Savickiene
Asta
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Kauno medicinos universiteto Reumatologijos klinika, Eiveniu 2, 3007 Kaunas.
Baranauskaite
Asta
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D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D015519:Bone Density; D003627:Data Interpretation, Statistical; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013997:Time Factors
D005938:Glucocorticoids