[A case report of hepatocellular carcinoma with portal thrombus responding to hepatic arterial infusion chemo-lipiodolization].
A 73-year old man with multiple hepatocellular carcinomas underwent 4 transarterial chemoembolizations, but a tumor thrombus appeared in the left portal vein. The tumor sizes in segments 4 and 5 were 4.0 cm and 2.4 cm, respectively. The serum levels of AFP and PIVKA-II were 14,991 ng/ml and 15,944 mAU/ml, respectively. The tumor was 5-FU palpable in the epigastric region. Four ml of SMANCS and 4 ml of Lipiodol were injected to proper hepatic artery using the Seldinger technique. In addition, epirubicin (20 mg), MMC (4 mg) and Lipiodoi (2 ml) were injected into a proper hepatic artery via a reservoir every 3 weeks. The tumor was not palpable, and the tumor markers were markedly reduced after 2 months. The evaluation of response to the treatment was a partial response 3 months and 6 months later. Chemo-lipiodolization was very useful for advanced hepatocellular carcinoma with portal vein thrombus.
Masutani
Seizo
S
Dept. of Surgery, Sakai Municipal Hospital.
Shimizu
Junzo
J
Tatsuta
Masayuki
M
Katoh
Hitoshi
H
Kitani
Kotaro
K
Esumi
Kouji
K
Masuda
Norikazu
N
Imamura
Hiroshi
H
Ishida
Hideyuki
H
Furukawa
Hiroshi
H
Onishi
Hiromitsu
H
Tsuda
Kyo
K
Inoue
Yutaka
Y
Tomotsu
Kouichi
K
Usui
Tatsuhiko
T
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local; D011169:Portal Vein; D013927:Thrombosis / Q000150:complications*
D015251:Epirubicin; D016685:Mitomycin; D007459:Iodized Oil