title: Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV.
abstract: Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8+ T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines.
authors.affiliation: Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street JFB809, Boston, MA 02115, USA.
authors.forename: Flavia
authors.initials: F
authors.lastname: Ferrantelli
authors.forename: Robert A
authors.initials: RA
authors.lastname: Rasmussen
authors.forename: Regina
authors.initials: R
authors.lastname: Hofmann-Lehmann
authors.forename: Weidong
authors.initials: W
authors.lastname: Xu
authors.forename: Harold M
authors.initials: HM
authors.lastname: McClure
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Ruprecht
mesh_terms: D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002908:Chronic Disease; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D016219:Immunotherapy, Adoptive; D009500:Neutralization Tests
chemical_list: D000911:Antibodies, Monoclonal