Dendritic architecture of corticothalamic neurons in a rat model of microgyria.
METHODS
Freezing lesions of the sensorimotor cortex resembling focal human microgyria were carried out in newborn rats on first postnatal day (P1). The fine architecture of dendritic trees of corticothalamic neurons was studied in microgyric animals on P90.


CONCLUSIONS
Compared with controls, layer 5 corticothalamic neurons located in the cortex surrounding the experimental lesion display longer basal dendrites. This finding is discussed with reference to earlier results on dendrites of layer 3 associative neurons, which, in contrast to those of corticothalamic neurons, appear to be markedly simplified.
Di Rocco
Federico
F
Institute of Neurosurgery, Catholic University School of Medicine, Largo A Gemelli, 8, 00168 Rome, Italy.
Giannetti
Stefano
S
Gaglini
Pierpaolo
P
Di Rocco
Concezio
C
Granato
Alberto
A
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology*; D003712:Dendrites / Q000473:pathology*; D004195:Disease Models, Animal; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000002:abnormalities* / Q000473:pathology*