title: The effects of high stimulus rate on the electrocochleogram in normal-hearing subjects.
abstract: The use of high stimulus rates has the potential to improve the electrocochleogram's (ECochG) sensitivity and specificity in endolymphatic hydrops and Menière's disease, but is currently hindered by the absence of an acceptable normative database. In response, this study recorded click-evoked ECochG tracings from 51 normal-hearing subjects (102 ears), between 18 and 60 years of age, at 7.1, 51.1, 101.1 and 151.1 clicks/s using a tympanic membrane electrode. As stimulus rate increased, various statistically significant (p < 0.05) changes were observed. In general, summating potential (SP) latency and amplitude and action potential (AP) latency increased, SP/AP amplitude ratio and waveform width increased but then plateaued, and AP amplitude fluctuated. While providing the largest contribution to a high-stimulus-rate ECochG normative database published to date, potential clinical limitations were identified and a possible solution proposed.
authors.affiliation: Department of Speech Pathology and Audiology, University of the Witwatersrand, Johannesburg, South Africa. w.wilson@shrs.uq.edu.au
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Wilson
authors.forename: Caren A
authors.initials: CA
authors.lastname: Bowker
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001300:Audiometry, Evoked Response / Q000295:instrumentation*; D004566:Electrodes; D018159:Endolymphatic Hydrops / Q000175:diagnosis; D005260:Female; D006309:Hearing / Q000502:physiology*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D014432:Tympanic Membrane