[Is there still a role for standard nonsteroidal antirheumatic agents?].
Although beneficial and widely used, nonsteroidal anti-inflammatory drugs (NSAID) are asociated with serious gastrointestinal (GI) side effects including ulceration, hemorrhage, and perforation with annual incidence of 2-4%. Prevention of NSAID-induced gastroduodenal ulcerations with proton pump inhibitors (IPP) is recommended in patients wit greater risk for serious GI complications. It is reasonable to expect that specific inhibitors of COX-2 drugs will be used in 20-30% of patients when NSAID are needed. That still leaves great importance on conventional NSAID. If an NSAID is indicated, it should be given at the lowest effective dose with regard to specific indication.
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Klinika za reumatske bolesti i rehabilitaciju, Medicinski fakultet Sveucilista u Zagrebu.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012216:Rheumatic Diseases / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal