Intravascular lymphomatosis presenting as systemic inflammatory response syndrome.
Intravascular lymphomatosis is an unusual form of non-Hodgkin lymphoma characterized by intravascular proliferation of atypical lymphoid cells in multiple organs. It can cause systemic inflammatory response syndrome due to primary release of cytokines by the tumor cells or secondary release of cytokines after vascular occlusion by the tumor cells. It is a potentially fatal condition, because multiorgan failure can ensue due to thrombotic vascular occlusion. This is a very rare condition and most cases are diagnosed post mortem. We present a case of systemic inflammatory response syndrome and subsequent death from multiorgan failure in a patient with intravascular lymphoma.
Yalamanchili
Madhuri
M
Department of Internal Medicine, Guthrie/Robert Packer Hospital, Sayre, Pennsylvania, USA. madhuriyalamanchili@yahoo.com
Prabhu
Sheela
S
Bradstreet
Perry
P
Chouhdry
Iftikhar
I
Walsh
James
J
D001808:Blood Vessels / Q000276:immunology / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000503:physiopathology