[Prostaglandin E1 versus sildenafil in the management of erectile dysfunction].
OBJECTIVE
To evaluate the outcome of treatment in patients with erectile dysfunction (ED) using sildenafil or intracavernosal injection of prostaglandin E1(PGE1).


METHODS
54 patients with ED were randomly classified into two groups and received either oral sildenafil (group A) or intracavernosal injection of PGE1(group B) for 4-9 months with an average of 6 months.


RESULTS
The percentages of efficacy in the two groups were 80.0% and 83.3%, respectively. There was no statistical difference between group A and B (P > 0.05). Two of six patients who did not respond to sildenafal in group A achieved erections sufficient for sexual intercourse when the six patients received intracavernous injection of PGE1. None of the four patients who did not respond to intracavernous injection of PEG1 in group B achieved erection sufficient for sexual intercourse when they received oral sildenafil.


CONCLUSIONS
Both oral sildenafil and intracavernous injection of PGE1 are effective for patients with ED of various etiologies. The patients who do not respond to sildenafil can receive intracavernous injection therapy. The satisfactory results can probably achieved.
Wang
Zhen-Lin
ZL
Department of Urology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, China. wangzhenlin@hotmail.com
Li
Bin
B
Yan
Jing-Zhong
JZ
Dong
Sheng-Guo
SG
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D004333:Drug Administration Routes; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D016896:Treatment Outcome
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D000527:Alprostadil