Application of recombinant activated factor VII for treatment of impaired haemostasis during liver transplantation in recipients with Wilson's disease--a report of two cases.
Recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Denmark) is a treatment used to prevent and arrest intra- and postoperative bleeding in patients with haemophilia A or B complicated by circulating anticoagulants (inhibitors of FVIII and FIX) and in patients without haemophilia who spontaneously develop inhibitors of FVIII, i.e. in acquired haemophilia. Patients who qualify for liver transplantation due to liver dysfunction may have varying degrees of coagulation impairment and thus carry an elevated risk of massive bleeding and have worse prognosis. The authors administered recombinant activated factor VII to two patients with coagulation abnormalities in the course of Wilson's disease during liver transplantation.
Jureczko
L
L
Department of Anaesthesiology and Intensive Care, Medical University of Warsaw. Lidka_j@hotmail.com
Trzebicki
J
J
Zawadzki
A
A
Pacholczyk
M
M
Łagiewska
B
B
Kołacz
M
M
Szyszko
G
G
Mayzner-Zawadzka
E
E
D000293:Adolescent; D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005167:Factor VII / Q000627:therapeutic use*; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006527:Hepatolenticular Degeneration / Q000601:surgery*; D006801:Humans; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000379:methods*; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D005167:Factor VII