Signaling chromatin to make muscle.
Several findings published within the past year have further established key roles for chromatin-modifying enzymes in the control of muscle gene expression, and have thus refined our thinking of how chromatin structure influences muscle differentiation, hypertrophy and fiber type determination. We discuss the interface between chromatin-modifying enzymes and myogenic transcription factors, signaling mechanisms that impinge on these transcriptional complexes, and how these multicomponent regulatory cascades may be exploited in the development of novel therapeutics to more effectively treat myopathies in humans.
McKinsey
Timothy A
TA
Myogen, Inc., 7575 West 103rd Avenue, Westminster, CO 80021, USA.
Zhang
Chun Li
CL
Olson
Eric N
EN
D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D064326:MEF2 Transcription Factors; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D017570:MyoD Protein / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D018006:Myogenic Regulatory Factors; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D002843:Chromatin; D004268:DNA-Binding Proteins; D064326:MEF2 Transcription Factors; D017570:MyoD Protein; D018006:Myogenic Regulatory Factors; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D011484:Protein-Arginine N-Methyltransferases; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases