Protection against UVB irradiation by natural filters extracted from lichens.
Natural substances extracted from lichens and boldo tree were tested in vivo and in vitro as possible UV-light filters. The protection factors were compared with that found for the references: Nivea sun Spray LSF 5, octylmethoxycinnamate (OMC) and 4-tert.-butyl-4'-methoxy dibenzoylmethane (BM-DBM). The stability of the single compounds was studied through UV-Vis spectroscopy. Usnic acid resulted to be the best UVB filter, with an in vivo protection factor similar to Nivea sun Spray LSF 5. Most of the single compounds studied in vitro resulted to have higher or similar filtering power than octylmethoxycinnamate. The protection factors as well as the good UV-light absorption of their photo-products suggest that these natural substances may be useful as new filters in sun-screen preparations.
Rancan
Fiorenza
F
Department of Dermatology, Humboldt University (Charité), 10117 Berlin, Germany.
Rosan
Stefania
S
Boehm
Kirsten
K
Fernández
Ernesto
E
Hidalgo
M Eliana
ME
Quihot
Wanda
W
Rubio
Cecilia
C
Boehm
Fritz
F
Piazena
Helmut
H
Oltmanns
Ute
U
D001060:Aporphines / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D019169:Jurkat Cells; D008011:Lichens / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D013473:Sunscreening Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays
D001060:Aporphines; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D013473:Sunscreening Agents; C011686:boldine