title: [Changes of plasma interleukin-4, interleukin-10 and interleukin-13 in patients with acute respiratory distress syndrome].
abstract: OBJECTIVE
  To explore the anti-inflammatory mechanisms of interleukin-4 (IL-4), interleukin-10 (IL-10) and interleukin-13 (IL-13) in acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  Enzyme-linked immunosorbent assay (ELISA) was employed to determine the plasma levels of IL-4, IL-10 and IL-13 in patients with ARDS (n = 22) and systemic inflammatory response syndrome (SIRS, n = 8). Ten normal subjects were enrolled as controls.
  
  
  RESULTS
  The plasma levels of IL-4, IL-10 and IL-13 were (261 +/- 55) microg/L, (458 +/- 112) microg/L and (5.21 +/- 2.02) microg/L, respectively in patients with ARDS; (155 +/- 26) micro g/L, (260 +/- 54) microg/L and (1.69 +/- 0.39) microg/L respectively in patients with SIRS; and (43 +/- 13) microg/L, (135 +/- 15) microg/L and (0.33 +/- 0.10) microg/L, respectively in normal controls. They were significantly increased in patients with ARDS and SIRS as compared to normal controls, and the levels were higher in patients with ARDS than in patients with SIRS.
  
  
  CONCLUSIONS
  Increased release of anti-inflammatory cytokines, such as IL-4, IL-10 and IL-13, may be one of the underlining mechanisms for the development of ARDS and SIRS.
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Guisheng
authors.initials: G
authors.lastname: Qian
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jinqian
authors.initials: J
authors.lastname: Gong
authors.forename: Zhengcai
authors.initials: Z
authors.lastname: Tang
authors.forename: Zhengjin
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D018793:Interleukin-13 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology
chemical_list: D018793:Interleukin-13; D016753:Interleukin-10; D015847:Interleukin-4