title: Fosmidomycin for malaria.
abstract: Safe and effective antimalarial drugs with new methods of action are urgently needed. Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the growth of multidrug-resistant strains in vitro. Our aim was to assess the efficacy and tolerability of fosmidomycin in adults with malaria in Gabon. We administered the drug for 5, 4, or 3 days (1.2 g every 8 h), in nine, eight, and ten evaluable patients, respectively. All treatment regimens were well tolerated. Cure rates by day 14 were 89% (eight of nine), 88% (seven of eight), and 60% (six of ten), for treatment durations of 5, 4, and 3 days, respectively. These data suggest that fosmidomycin is a safe and effective treatment for uncomplicated malaria if given for 4 days or more.
authors.affiliation: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon
authors.forename: Michel A
authors.initials: MA
authors.lastname: Missinou
authors.forename: Steffen
authors.initials: S
authors.lastname: Borrmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Schindler
authors.forename: Saadou
authors.initials: S
authors.lastname: Issifou
authors.forename: Ayola A
authors.initials: AA
authors.lastname: Adegnika
authors.forename: Pierre-Blaise
authors.initials: PB
authors.lastname: Matsiegui
authors.forename: Ronald
authors.initials: R
authors.lastname: Binder
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lell
authors.forename: Jochen
authors.initials: J
authors.lastname: Wiesner
authors.forename: Thomas
authors.initials: T
authors.lastname: Baranek
authors.forename: Hassan
authors.initials: H
authors.lastname: Jomaa
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000328:Adult; D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005681:Gabon; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D005578:Fosfomycin; C024640:fosmidomycin