Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-l-cysteine.
Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-l-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.
Kelly
Raymond G
RG
Department of Medicine, University College Cork, Ireland.
Nally
Kenneth
K
Shanahan
Fergus
F
O'Connell
Joe
J
D000111:Acetylcysteine / Q000494:pharmacology*; D000230:Adenocarcinoma; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D015179:Colorectal Neoplasms; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D017526:Receptor, IGF Type 1; D000111:Acetylcysteine