title: Human herpesvirus 6B infection of the large intestine of patients with diarrhea.
abstract: Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. kiyokoamo@pop12.odn.ne.jp
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Amo
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka-Taya
authors.forename: Reiko
authors.initials: R
authors.lastname: Inagi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyagawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Okusu
authors.forename: Junji
authors.initials: J
authors.lastname: Sashihara
authors.forename: Junichi
authors.initials: J
authors.lastname: Hara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakayama
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamanishi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Okada
mesh_terms: D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000503:physiopathology / Q000821:virology*; D007420:Intestine, Large; D008297:Male; D019349:Roseolovirus Infections / Q000503:physiopathology / Q000821:virology*; D033581:Stem Cell Transplantation