Serum soluble interleukin-2 receptor in eosinophilia.
The relationship between soluble interleukin-2 receptor (sIL-2R) levels and clinical characteristics was evaluated in patients with eosinophilia. Thirty-eight out of 60 patients showed sIL-2R levels of more than 800 U/ml. In these patients, sIL-2R was closely related to the eosinophil count, but not the IgE level. Their underlying diseases were heterogeneous, including neoplasms and collagen diseases. In patients with lower sIL-2R levels, there was no relationship to the eosinophil count, but sIL-2R was correlated with the IgE level. These findings indicate that patients with eosinophilia and higher sIL-2R levels tend to have underlying diseases other than allergy, and might be more severely ill than patients with lower sIL-2R levels. sIL-2R may be a good marker for evaluating patients with eosinophilia, as an indicator of the probable etiology and severity of their diseases.
Kaito
Ken
K
Central Clinical Laboratory, Jikei University Hospital, Division of Hematology and Oncology, Jikei University School of Medicine, Tokyo, Japan. ken.kaito@jikei.ac.jp
Otsubo
Hiroko
H
Ogasawara
Yoji
Y
Kimura
Hiroko
H
Kurihara
Etsuko
E
Koike
Masaru
M
Aiso
Masayoshi
M
Kobayashi
Masayuki
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003627:Data Interpretation, Statistical; D004802:Eosinophilia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012720:Severity of Illness Index; D012995:Solubility
D015415:Biomarkers; D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E