[Pharmacokinetic study of CPT-11, SN-38 and SN-38 glucuronide in the ascites, plasma and bile after intraperitoneal administration of CPT-11].
We studied the pharmacokinetics of CPT-11 with intraperitoneal administration in a patient with a PTCD tube. The patient had advanced gastric cancer with peritoneal metastasis. CPT-11 was administrated in a dose of 40 mg and the intraperitoneal, plasma and bile levels of CPT-11, SN-38 and SN-38 glucuronide (SN-38 GLU) were measured periodically. The results showed that the periodical concentration pattern of CPT-11, SN-38 and SN-38 GLU in the bile was closely related to that of CPT-11 in the abdominal cavity.
Natsui
Shinsuke
S
Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
Maruyama
Michio
M
Ochiai
Takanori
T
Hasegawa
Kumi
K
Takashima
Itaru
I
Nagahama
Takeshi
T
Ebuchi
Masakazu
M
D000368:Aged; D000369:Aged, 80 and over; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001201:Ascites / Q000378:metabolism; D001646:Bile / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D020719:Glucuronides / Q000493:pharmacokinetics*; D006801:Humans; D007263:Infusions, Parenteral; D000077146:Irinotecan; D008297:Male; D013274:Stomach Neoplasms / Q000188:drug therapy
C441475:7-ethyl-10-hydroxycamptothecin glucuronide; D000972:Antineoplastic Agents, Phytogenic; D020719:Glucuronides; D000077146:Irinotecan; D002166:Camptothecin