Linkage mapping of quantitative trait loci in humans: an overview.
In this article, we provide an overview of the different statistical procedures that have been developed for linkage mapping of quantitative trait loci. We outline the model assumptions, the data requirements and the underlying tests for linkage for the different methods.
Ghosh
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110-1093, USA. saurabh@silver.wustl.edu
Reich
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T
Majumder
P P
PP
D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D016013:Likelihood Functions; D008957:Models, Genetic; D010641:Phenotype; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric