title: [A case of postoperative liver metastasis of alpha-fetoprotein producing gastric cancer successfully treated with intrahepatic chemotherapy (adriamycin, cisplatin, irinotecan hydrochloride)].
abstract: There are only a few reports demonstrating effective regimens for AFP-producing gastric cancer. We report a case of alpha-fetoprotein (AFP)-producing gastric cancer successfully treated with postoperative intrahepatic chemotherapy, together with a review of the literature. A 63-year-old man was diagnosed as having multiple liver metastases 6 months following total gastrectomy for type 2 gastric cancer. Serum AFP level was markedly elevated at 291.4 ng/ml although the level was not determined at the time of gastrectomy. Twenty cycles of intrahepatic arterial infusion with adriamycin, cisplatin, and irinotecan hydrochloride resulted in a 93% decrease in the liver metastases along with normalization of the serum AFP level. These results suggest that this regimen is worth trying for patients with liver metastasis from AFP-producing gastric cancer.
authors.affiliation: Dept. of Surgery, Saitama Medical Center.
authors.forename: Jun
authors.initials: J
authors.lastname: Sobajima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Murata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Daijo
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Adachi
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoyama
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000509:alpha-Fetoproteins; D000077146:Irinotecan; D004317:Doxorubicin; D002945:Cisplatin; D002166:Camptothecin