title: Neutralization titres and vertical HIV-1 transmission.
abstract: Replication of the human immunodeficiency virus type 1 (HIV-1) isolate MN in CEM cells was less neutralized by the plasma from the mothers of infected children (MIC) in comparison with the plasma from the mothers of uninfected children (MUC). Significantly higher neutralization titres were observed for the sera from MUCs compared with MICs, and only the sera from MUC showed 100% neutralization of the HIV-1 MN strain. We suggest that a simple neutralization assay as described here could be useful in prognostic analyses.
authors.affiliation: AIDS and Molecular Immunology Laboratory, Department of Immunology, IOC, FIOCRUZ, Brazil. bongertz@ioc.fiocruz.br
authors.forename: V
authors.initials: V
authors.lastname: Bongertz
authors.forename: C I
authors.initials: CI
authors.lastname: Costa
authors.forename: V G
authors.initials: VG
authors.lastname: Veloso
authors.forename: B
authors.initials: B
authors.lastname: Grinsztejn
authors.forename: E C J
authors.initials: EC
authors.lastname: Filho
authors.forename: G
authors.initials: G
authors.lastname: Calvet
authors.forename: J H
authors.initials: JH
authors.lastname: Pilotto
mesh_terms: D002460:Cell Line; D002648:Child; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000494:pharmacology*; D015658:HIV Infections / Q000276:immunology / Q000635:transmission*; D015497:HIV-1 / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D009500:Neutralization Tests; D014779:Virus Replication
chemical_list: D015483:HIV Antibodies