Effect of dialysis on erythrocyte membrane of chronically hemodialyzed patients.
The present work examines the role of uremia and the effect of dialysis treatment on red blood cells (RBCs) membrane properties of hemodialysis patients. The results showed that, the uremic patients had a lower values of erythrocyte deformability than that of healthy control subject. The median osmotic fragility (MOF) showed a significant increase in hemodialyzed patients than that for control group. The osmotic resistance to hemolysis was improved after dialysis. The solubilization process of the RBCs membrane showed that the detergent concentration needed to solubilize the RBCs membrane for uremic patient was much higher than that for control group. The abnormalities of the present results for RBCs membrane properties are mostly related to membrane fluidity, which are slightly improved after dialysis. Biochemical analysis showed a decreasing trend in RBCs count, urea nitrogen, creatinine, potassium,
Ibrahim
Fakhry F
FF
Department of Clinical Pathology, Cairo University Hospitals, Egypt. fakhryi@yahoo.com
Ghannam
Magdy M
MM
Ali
Fadel M
FM
D000328:Adult; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D015312:Hemodialysis Solutions / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008875:Middle Aged; D009996:Osmotic Fragility / Q000187:drug effects; D006435:Renal Dialysis; D012995:Solubility / Q000187:drug effects; D014511:Uremia / Q000628:therapy*
D015312:Hemodialysis Solutions