[The changes of IL-1 and NO levels in the testes of rats with experimental varicocele].
OBJECTIVE
To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC.


METHODS
Male adult Wistar rats were divided into two groups randomly, VC group (n = 30) and pseudo-operation group (n = 20), and the levels of IL-1 and NO in the testes were determined and compared.


RESULTS
The levels of IL-1 and No of left tests in VC group were higher than those in pseudo-operation group, respectively(P < 0.01). While the levels of IL-1 and NO of right testes between two groups were not significantly different (P > 0.05). More over, the level of IL-1 correlated significantly with that of NO(r = 0.572, P < 0.01).


CONCLUSIONS
The results revealed that the changes of IL-1 and NO levels in the testes of rats with VC might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility.
Chen
Li-Ping
LP
Department of Obstetric and Gynecology, Jiamusi Center Hospital, Jiamusi, Heilongjiang 154002, China.
Wang
Shu-Qiu
SQ
Zhao
Yu-Zhen
YZ
Liu
Lei
L
Wang
Shu-Xiang
SX
Lu
Ya-Zhen
YZ
D000818:Animals; D004195:Disease Models, Animal; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000378:metabolism* / Q000648:ultrastructure; D014646:Varicocele / Q000378:metabolism*
D007375:Interleukin-1; D009569:Nitric Oxide