Alkylaminopropenones and alkylamino-propenoates as efficient and versatile synthons in microwave-assisted combinatorial synthesis.
A simple and fast one-pot method using microwave irradiation for the synthesis of a number of small libraries of diverse heterocycles is described in this paper. The two-step one-pot method includes the formation of alkylaminopropenones or alkylaminopropenoates in 5 min at 180 degrees C and a subsequent treatment with dinucleophiles for 3 to 5 min at 150 degrees C to 180 degrees C to form a variety of biologically interesting heterocycles in a cascade-type reaction. The combination of combinatorial chemistry and microwave-assisted synthesis was found to be very efficient.
Westman
J
J
Personal Chemistry AB, Kungsgatan 76, Uppsala, 753 18, Sweden. jacob.westman@personalchemistry.com
Lundin
R
R
Stålberg
J
J
Ostbye
M
M
Franzén
A
A
Hurynowicz
A
A
D000588:Amines / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure
D000588:Amines; D006571:Heterocyclic Compounds