RNA export: insights from viral models.
The retroviruses export intron-containing RNA. The complex retroviruses encode a Rev protein that uses a leucine-rich NES to interact with CRM1 and the U snRNA-export pathway. Other viruses encode proteins with a Rev-like NES. The type-D retroviruses contain a CTE that binds the cellular protein TAP to export intron-containing RNA through the mRNA pathway. Intronless viral transcripts contain post-transcriptionally acting RNA elements that may compensate for the lack of an intron. The functions of elements in intronless RNA are not fully understood but may be in export and/or 3'-end processing.
Harris
M E
ME
Infectious Disease Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Hope
T J
TJ
D021581:Active Transport, Cell Nucleus / Q000235:genetics; D000818:Animals; D015967:Gene Expression Regulation, Viral; D015694:Gene Products, rev / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007438:Introns / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012367:RNA, Viral / Q000378:metabolism*; D012190:Retroviridae / Q000235:genetics*
D015694:Gene Products, rev; D012367:RNA, Viral