title: Familial prostate and breast cancer in men treated with prostatectomy for prostate cancer: a population based case-control study.
abstract: OBJECTIVE
  We assessed familial prostate and breast cancer in Quebec.
  
  
  METHODS
  Using a self-administered mail survey we assessed the prevalence of prostate and breast cancer in first degree relatives of 1,633 men treated with prostatectomy for prostate cancer in the province of Quebec and in first degree relatives of 1,386 spouse controls.
  
  
  RESULTS
  The OR of familial breast cancer was 1.1 (95% CI 0.9 to 1.4). The OR of 3.0 (95% CI 2.5 to 3.6) recorded for prostate cancer was modified by francophone versus anglophone linguistic preference (OR 3.2, 95% CI 2.6, 3.9 versus 1.5, 95% CI 0.8 to 2.7, p = 0.02). Male sibship size was a statistically significant parameter modifying this association (p = 0.02), namely no brothers (OR 1.7, 95% CI 1.0 to 2.8), 1 or 2 (OR 3.1, 95% CI 2.2 to 4.3) and 3 or more (OR 3.9, 95% CI 2.9 to 5.2). Geographic regions of the province including and neighboring greater Montreal showed a lower OR than more peripheral regions (2.5, 95% CI 2.0 to 3.2 versus 4.1, 95% CI 2.9 to 5.7, p = 0.02).
  
  
  CONCLUSIONS
  Francophone men with large male sibships residing in remote areas may be at higher risk for familial prostate cancer and represent the ideal target for further efforts to determine the genetic component of prostate cancer in Quebec.
authors.affiliation: Department of Surgery (Urology), McGill University, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A41.
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
authors.forename: William
authors.initials: W
authors.lastname: Foulkes
authors.forename: Simon
authors.initials: S
authors.lastname: Tanguay
authors.forename: Mostafa  M
authors.initials: M
authors.lastname: Elhilali
authors.forename: Armen G
authors.initials: AG
authors.lastname: Aprikian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D011792:Quebec / Q000453:epidemiology; D012307:Risk Factors; D035781:Siblings; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires