Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation.
Manoharan
Muthiah
M
Isis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA. mmanoharan@isisph.com
Inamati
Gopal B
GB
Lesnik
Elena A
EA
Sioufi
Namir B
NB
Freier
Susan M
SM
D006801:Humans; D007052:Ibuprofen / Q000737:chemistry* / Q000494:pharmacology; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*
D016376:Oligonucleotides, Antisense; D012709:Serum Albumin; D007052:Ibuprofen