title: Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disorders.
abstract: The course of cognitive functioning over a 1-year period was examined among a community cohort of individuals presenting with first episode schizophrenia spectrum psychosis. Data were obtained for 83 outpatients at entry to an early intervention program and 12 months later on the National Adult Reading Test, Wechsler Adult Intelligence Scales-Third Edition, Wechsler Memory Scales-Third Edition, Paced Auditory Serial Addition Task, Wisconsin Card Sorting Test, Stroop Colour and Word Test, Trail Making Test, Continuous Performance Task and Thurstone Word Fluency Test. Paired sample t-tests indicated significant and positive changes in verbal and non-verbal intelligence, auditory and visual memory, working memory and some aspects of executive functioning. Processing speed also improved though remained an area of relative weakness for this sample. Findings indicated generally average performance at both assessment periods. Neither gender nor duration of untreated psychosis were related to the degree of change in cognitive functioning for this sample. The implications of these findings and the impact of early intervention with this population are discussed.
authors.affiliation: Department of Psychiatry, University of Western Ontario, 392 South Street, London, Ontario, Canada, N6A 4G5. Townsend@lhsc.on.ca
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Townsend
authors.forename: Ross M G
authors.initials: RM
authors.lastname: Norman
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Malla
authors.forename: Anita D
authors.initials: AD
authors.lastname: Rychlo
authors.forename: Rashid R
authors.initials: RR
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications*; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents