[The effect of acute urinary retention on serum prostate specific antigen concentration].
OBJECTIVE
To study the effect of acute urinary retention on the serum prostate-specific antigen (PSA) concentration.


METHODS
Blood samples from 34 benign prostatic hyperplasia (BPH) patients with acute urinary retention were drawn immediately before suprapubic cystomy and 48 hours after relief of urinary retention. Serum PSA concentrations were measured with radioimmunoassay.


RESULTS
The mean serum PSA levels of BPH patients with acute urinary retention was (24.6 +/- 16.1) micrograms/L (range from 2.6 micrograms/L to 45.8 micrograms/L). Forty-eight hours after relief of urinary retention, the mean serum PSA levels declined to (9.4 +/- 6.3) micrograms/L (range from 1.7 micrograms/L to 16.6 micrograms/L). The difference was significant (P < 0.01).


CONCLUSIONS
Acute urinary retention could dramatically increase the serum PSA value of patients with BPH. After relief of the urinary retention, the patients had a great than 50% decreased of PSA values.
Hua
Li-Xin
LX
Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Wu
Hong-Fei
HF
Sui
Yuan-Geng
YG
Cheng
Shuang-Guan
SG
Xu
Zhen-Quan
ZQ
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*; D016055:Urinary Retention / Q000097:blood*
D017430:Prostate-Specific Antigen