Hijacking the host cell proteasome.
Uropathogenic Escherichia coli subvert host cell signaling mechanisms to induce cellular responses that facilitate bacterial invasion and colonization. A recent publication in the November 15 issue of Cell shows that the bacterium may accomplish such a feat by hijacking the proteasome machinery.
Waksman
Gabriel
G
Department of Biochemistry and Molecular Biophysics, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
D001427:Bacterial Toxins / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D003603:Cytotoxins / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000378:metabolism* / Q000503:physiopathology; D029968:Escherichia coli Proteins; D006790:Host-Parasite Interactions / Q000502:physiology; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D001427:Bacterial Toxins; D003603:Cytotoxins; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; C060296:cytotoxic necrotizing factor type 1; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D020741:rho GTP-Binding Proteins