Skin allograft in the treatment of toxic epidermal necrolysis (TEN).
BACKGROUND
TEN is a severe form of exfoliative dermatitis. Its course is acute and its outcome fatal in 40% of cases. Wound cover to prevent fluid/protein loss and infections and to control pain, is the first step, as for burns. Skin allograft can be successfully used for this purpose.


OBJECTIVE
We report two cases of TEN with de-epithelialization of 50 and 70% of the total body surface area. The patients were given support therapy and treated with human glycerol-preserved skin allografts for wound cover.


METHODS
Patients were grafted with glycerol-preserved donor skin, obtained from a skin bank.


RESULTS
Re-epithelization of treated areas was complete in 8 days; pain relief was obtained soon after the graft.


CONCLUSIONS
Glycerol-preserved skin allograft is an effective treatment in extensive skin loss, for its barrier and analgesic effect. Quality standards of this product ensure safety and simplicity of use at limited cost.
Pianigiani
Elisa
E
Department of Dermatology and Skin Bank, Siena, Italy. pianigianie@unisi.it
Ierardi
Francesca
F
Taddeucci
Paolo
P
Perotti
Roberto
R
Biagioli
Maurizio
M
Di Simplicio
Francesca Cherubini
FC
Andreassi
Andrea
A
Fimiani
Michele
M
D000368:Aged; D000369:Aged, 80 and over; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D005260:Female; D005990:Glycerol; D006801:Humans; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D011899:Ranitidine / Q000627:therapeutic use; D016038:Skin Transplantation / Q000379:methods; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014184:Transplantation, Homologous
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D000667:Ampicillin; D011899:Ranitidine; D005990:Glycerol