title: Centrofacial malignant T-cell lymphoma exhibiting recurrent fever and skin ulcer in a 3-year-old girl.
abstract: A rare case of undetermined fever and skin ulcers is reported. The patient had an 8-month history of recurrent fever, destructive ulceration of the midline facial tissue, and symmetrical skin ulcer in the cheeks and the back of the hand. Pathological examination revealed that the patient had lethal midline granuloma (centrofacial malignant T-cell lymphoma), which is very rare in childhood. Centrofacial malignant T-cell lymphoma should be considered as a differential diagnosis of unexplained fever and skin ulcer in children.
authors.affiliation: Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. shounika@med.niigata-u.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Kakihara
authors.forename: Chihaya
authors.initials: C
authors.lastname: Imai
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hotta
authors.forename: Yukie
authors.initials: Y
authors.lastname: Ikarashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchiyama
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005334:Fever / Q000209:etiology; D006103:Granuloma, Lethal Midline / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D012883:Skin Ulcer / Q000209:etiology; D014182:Transplantation, Autologous