title: Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
abstract: The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.
authors.affiliation: Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S-75124, Sweden.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soubeyran
authors.forename: Ana
authors.initials: A
authors.lastname: Barac
authors.forename: Iwona
authors.initials: I
authors.lastname: Szymkiewicz
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D050722:Oncogene Protein v-cbl; D010766:Phosphorylation; D011485:Protein Binding; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism*; D016601:RNA-Binding Proteins; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism*; D020798:Two-Hybrid System Techniques; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018398:Homeodomain Proteins; D050722:Oncogene Protein v-cbl; D016601:RNA-Binding Proteins; D015682:Retroviridae Proteins, Oncogenic; C490755:SORBS2 protein, human; D025801:Ubiquitin; D016315:Proto-Oncogene Proteins c-abl