[Evaluation of the effect of obesity on selected haemostatic and fibrinolytic parameters in peri- and postmenopausal women].
Localization of adipose tissue influence on obesity-dependent diseases. In obese people many abnormalities are observed connected with coagulation factors and fibrinolysis. We studied 47 peri- and postmenopausal female patients, who were operated on for benign changes within the pelvis minor. The patients were divided according to BMI (group I--BMI < 25 kg/m2, group II--BMI > 29 kg/m2). In obese women lower SHBG concentration, higher insulin and glucose fasting blood levels, higher LDL, higher total fatty tissue content, higher fibrinogen level and elevated PAI-1 activity were found. A positive correlation between area under insulin curve and PAI-1 activity and a negative correlation between fasting insulin levels and tPA were also observed. Based on the studies performed it can be said that: 1. Fatty tissue content in postmenopausal women exerts an influence on PAI-1 activity. 2. Obesity influences coagulation and fibrinolysis system in peri- and postmenopausal women. 3. Carbohydrate metabolism disturbances have influence on PAI-1 activity in peri- and postmenopausal women.
Połać
Ireneusz
I
Klinika Ginekologii i Chorób Menopauzy Instytutu Centrum Zdrowia Matki Polki w Łodzi.
Stetkiewicz
Tomasz
T
Stachowiak
Grzegorz
G
Jedrzejczyk
Sławomir
S
Pertyński
Tomasz
T
Pakalski
Andrzej
A
Kowalska
Elzbieta
E
D015415:Biomarkers / Q000097:blood; D001779:Blood Coagulation Factors / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007328:Insulin / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D017697:Premenopause / Q000097:blood*; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D015415:Biomarkers; D001779:Blood Coagulation Factors; D001786:Blood Glucose; D008078:Cholesterol, LDL; D007328:Insulin; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D012738:Sex Hormone-Binding Globulin; D005340:Fibrinogen