title: Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels.
abstract: We examined the influence of the atypical antipsychotic agent clozapine compared to haloperidol, on levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate ester (both gamma-aminobutyric acid(A) (GABA(A)) receptor allosteric antagonists) in the rat cortex. i.p. injections of clozapine (5 and 15 mg/kg), but not haloperidol (1 mg/kg), for 8 days decreased rat brain cortical dehydroepiandrosterone and dehydroepiandrosterone sulfate levels. These findings support the role of neurosteroids and possibly GABA(A) receptor modulation in the mechanism of action of clozapine.
authors.affiliation: Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Beilinson Campus, Petah Tiqva, Israel.
authors.forename: Allon
authors.initials: A
authors.lastname: Nechmad
authors.forename: Rachel
authors.initials: R
authors.lastname: Maayan
authors.forename: Edward
authors.initials: E
authors.lastname: Ramadan
authors.forename: Oren
authors.initials: O
authors.lastname: Morad
authors.forename: Michael
authors.initials: M
authors.lastname: Poyurovsky
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology*; D003687:Dehydroepiandrosterone / Q000032:analysis / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000032:analysis / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000502:physiology
chemical_list: D018492:Dopamine Antagonists; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D003024:Clozapine; D006220:Haloperidol