title: Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences.
abstract: The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.
authors.affiliation: Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Pellettieri
authors.forename: Geraldine
authors.initials: G
authors.lastname: Seydoux
mesh_terms: D000818:Animals; D019521:Body Patterning; D017173:Caenorhabditis elegans / Q000166:cytology / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D016764:Cell Polarity; D003593:Cytoplasm / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology*; D005306:Fertilization; D017238:Genes, Helminth; D017344:Genes, Insect; D008870:Microtubules / Q000502:physiology; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D009866:Oogenesis; D010063:Ovum / Q000166:cytology / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D015053:Zygote / Q000166:cytology / Q000502:physiology
chemical_list: D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; C409406:PAR-1 protein, C elegans; D017346:Protein Serine-Threonine Kinases