title: Thrombotic thrombocytopenic purpura associated with ticlopidine.
abstract: Thrombotic thrombocytopenic purpura is a syndrome characterized by hemolytic anemia, thrombocytopenia, neurological symptoms, fever and renal dysfunction. Although the syndrome is usually associated with various infections, vasculitis and pregnancy, rarely can it be associated with certain neoplasms and drugs such as ticlopidine. A 63-year-old woman, who had undergone coronary angioplasty and had been started on ticlopidine, was admitted to our clinic with a history of vomiting, fatigue, hematuria and deterioration in her cognitive abilities. Thrombotic thrombocytopenic purpura was diagnosed on the basis of neurological changes, an increase in LDH, urea, creatinine, indirect bilirubin levels, anemia and peripheral smear findings. Treatment was initiated with daily plasmapheresis and complete clinical and laboratory recovery developed. The patient was discharged after 14 days.
authors.affiliation: Department of Hematology and Oncology, GATA Haydarpaşa Training Hospital, Istanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Türken
authors.forename: Ahmet
authors.initials: A
authors.lastname: Oztürk
authors.forename: Bülent
authors.initials: B
authors.lastname: Orhan
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kandemir
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yaylaci
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000175:diagnosis*; D013988:Ticlopidine / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine