title: Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
abstract: X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay. We present cinematographic material of 11 cases of Lubag carrying the XDP haplotypes who manifest with a wide spectrum of movement disorders, including dystonia, tremor, parkinsonism, myoclonus, chorea, and myorhythmia. Because of overlapping features, Lubag patients are commonly misdiagnosed as idiopathic dystonia, essential tremor, Parkinson's disease, or Parkinson's-plus syndromes. Thus, it is imperative to elicit an exhaustive family history in any Filipino male adult who presents with a movement disorder.
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA. evidente.virgilio@mayo.edu
authors.forename: Virgilio Gerald H
authors.initials: VG
authors.lastname: Evidente
authors.forename: Joel
authors.initials: J
authors.lastname: Advincula
authors.forename: Raymund
authors.initials: R
authors.lastname: Esteban
authors.forename: Paul
authors.initials: P
authors.lastname: Pasco
authors.forename: Jhoe Anthony
authors.initials: JA
authors.lastname: Alfon
authors.forename: Filipinas F
authors.initials: FF
authors.lastname: Natividad
authors.forename: Joven
authors.initials: J
authors.lastname: Cuanang
authors.forename: Amado San
authors.initials: AS
authors.lastname: Luis
authors.forename: Katrina
authors.initials: K
authors.lastname: Gwinn-Hardy
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Dena
authors.initials: D
authors.lastname: Hernandez
authors.forename: Andrew
authors.initials: A
authors.lastname: Singleton
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D020821:Dystonic Disorders / Q000175:diagnosis / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D006580:Genetic Carrier Screening; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000235:genetics*; D010641:Phenotype; D010679:Philippines / Q000208:ethnology; D014481:United States
chemical_list: D005819:Genetic Markers