title: Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods.
abstract: Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Diplopoda). They were grown in submerged culture and investigated by biological assays and HPLC-diode array analysis regarding their production of bioactive metabolites, which were isolated and determined in structure. Known compounds and yet unknown derivatives from the primary metabolism were detected, as well as antibacterially and antifungally acting peptide antibiotics.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, D-72076 Tübingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Gebhardt
authors.forename: Judith
authors.initials: J
authors.lastname: Schimana
authors.forename: Johannes
authors.initials: J
authors.lastname: Müller
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Helmut G
authors.initials: HG
authors.lastname: Kallenborn
authors.forename: Meike
authors.initials: M
authors.lastname: Holzenkämpfer
authors.forename: Philipp
authors.initials: P
authors.lastname: Krastel
authors.forename: Axel
authors.initials: A
authors.lastname: Zeeck
authors.forename: Joachim
authors.initials: J
authors.lastname: Vater
authors.forename: Alexandra
authors.initials: A
authors.lastname: Höltzel
authors.forename: Dietmar G
authors.initials: DG
authors.lastname: Schmid
authors.forename: Joachim
authors.initials: J
authors.lastname: Rheinheimer
authors.forename: Konrad
authors.initials: K
authors.lastname: Dettner
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000145:classification / Q000302:isolation & purification; D023181:Antimicrobial Cationic Peptides; D001181:Arthropods / Q000033:anatomy & histology / Q000145:classification / Q000382:microbiology*; D001407:Bacillus / Q000737:chemistry* / Q000302:isolation & purification; D001414:Bacitracin / Q000302:isolation & purification; D006540:Herbicides / Q000145:classification / Q000302:isolation & purification; D019271:Hypoxanthine / Q000302:isolation & purification; D008958:Models, Molecular; D010455:Peptides; D013559:Symbiosis; D014363:Tryptamines / Q000302:isolation & purification; D014498:Uracil / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D006540:Herbicides; D010455:Peptides; D014363:Tryptamines; D001414:Bacitracin; D019271:Hypoxanthine; C030820:tryptamine; D014498:Uracil; C027845:bacillomycin D