title: Catheter-based transendocardial gene delivery for therapeutic myocardial angiogenesis.
abstract: Currently it is unknown which is the most effective and safest delivery strategy for therapeutic myocardial angiogenesis. The enhancing effect of direct intramyocardial injection of angiogenic factors using either open-chest or catheter-based approaches on collateral function has been reported to occur in experimental models and among patients. This report reviews the rationale and current experience of using a catheter-based approach as a promising platform for proangiogenic intramyocardial gene delivery strategy.
authors.affiliation: Director, Myocardial Revascularization and Angiogenesis, Cardiovascular Research Institute, Washington Hospital Center, 110 Irving St, NW, Suite 4B-1, Washington, DC 20010, USA.
authors.forename: Ran
authors.initials: R
authors.lastname: Kornowski
authors.forename: Shmuel
authors.initials: S
authors.lastname: Fuchs