title: Endolymphatic sac enhancement: reversal of pathogenesis.
abstract: As this article and many other publications have indicated, many thousands of patients with incapacitating intractable progressive Meniere's disease have had their lives restored through endolymphatic sac enhancement surgery. This is the only nondestructive procedure for Meniere's disease that has stood the test of time. Destructive procedures such as labyrinthectomy (chemical or physical) and vestibular nerve section are reserved for rare cases of failure or recurrence after sac enhancement, despite revision of the enhancement. There is much evidence to support the concept that endolymphatic sac enhancement reverses or enhances the pathogenesis of Meniere's disease. With additional clinical and molecular biologic research, endolymphatic sac enhancement will continue to improve and become more efficacious in the new millennium.
authors.affiliation: Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA. papar001@tc.umn.edu
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
authors.forename: Manuela
authors.initials: M
authors.lastname: Fina
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001300:Audiometry, Evoked Response; D002675:Child, Preschool; D020099:Coated Materials, Biocompatible; D004129:Dimethylpolysiloxanes; D004712:Endolymphatic Sac / Q000601:surgery*; D005781:Gelatin Sponge, Absorbable; D006309:Hearing; D006801:Humans; D008416:Mastoid / Q000601:surgery; D008575:Meniere Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D008875:Middle Aged; D018579:Patient Selection; D011182:Postoperative Care; D011183:Postoperative Complications; D019736:Prostheses and Implants; D012828:Silicones; D014717:Vertigo / Q000209:etiology
chemical_list: D020099:Coated Materials, Biocompatible; D004129:Dimethylpolysiloxanes; D012828:Silicones; C013830:baysilon