title: Neural substrates of spoken language rehabilitation in an aphasic patient: an fMRI study.
abstract: Little is known about the neural counterparts of speech therapy in aphasic patients. An fMRI experiment was performed before and after a specific and intensive speech output therapy in RC, a patient with long-lasting speech output deficit following a left-sided ischemic lesion. Overt picture naming and picture/word rhyming were used as activation tasks in RC and 6 control subjects. The naming task concerned the output lexicon deficit to be rehabilitated while rhyming referred to preserved levels of processing and was used to control for repetition effect. The speech therapy program improved naming performance. By comparison to the pattern observed before therapy, the naming task after therapy induced a pattern of activation close to that observed in control subjects, involving left-sided language areas surrounding the lesion. Speech therapy effect was associated with activations in Broca's area and the left supra-marginal gyrus, which might reflect a therapy-induced phonological compensatory strategy for naming.
authors.affiliation: INSERM U 455 and Department of Neurology, CHU Purpan, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Léger
authors.forename: J F
authors.initials: JF
authors.lastname: Démonet
authors.forename: S
authors.initials: S
authors.lastname: Ruff
authors.forename: B
authors.initials: B
authors.lastname: Aithamon
authors.forename: B
authors.initials: B
authors.lastname: Touyeras
authors.forename: M
authors.initials: M
authors.lastname: Puel
authors.forename: K
authors.initials: K
authors.lastname: Boulanouar
authors.forename: D
authors.initials: D
authors.lastname: Cardebat
mesh_terms: D000328:Adult; D001037:Aphasia / Q000503:physiopathology* / Q000534:rehabilitation*; D002340:Carotid Artery Diseases / Q000503:physiopathology / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology / Q000534:rehabilitation; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D013070:Speech Therapy; D013238:Stereotaxic Techniques; D014796:Visual Perception / Q000502:physiology