Knockdown stands up.
In the past year, the genetic research of mammalian cells in vitro has gained the advantages of RNA interference (RNAi), a process found in worms and plants by which double stranded RNAs mediate selective gene inactivation through mRNA destruction. Recently, two papers have shown that genes could be suppressed in vivo in mammals by RNAi, which has potential implications for both therapeutics and research.
Voorhoeve
P Mathijs
PM
Division of Tumor Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Agami
Reuven
R
D000818:Animals; D020868:Gene Silencing; D005821:Genetic Techniques; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D034622:RNA Interference