Cytotoxic triterpenes from the twigs of Celtis philippinensis.
Two triterpene esters, 3beta-trans-sinapoyloxylup-20(29)-en-28-ol (1) and 3beta-trans-feruloyloxy-16 beta-hydroxylup-20(29)-ene (2), were isolated as cytotoxic constituents from the chloroform-soluble extract of the twigs of Celtis philippinensis, along with five known triterpenes, 3beta-O-(E)-feruloylbetulin (3), 3beta-O-(E)-coumaroylbetulin (4), betulin (5), 20-epibryonolic acid (6), and ursolic acid (7). The structures of 1 and 2 were assigned from their 1D and 2D NMR spectroscopic data. All isolates were evaluated for cytotoxicity against several human cancer cell lines.
Hwang
Bang Yeon
BY
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Chai
Hee-Byung
HB
Kardono
Leonardus B S
LB
Riswan
Soedarsono
S
Farnsworth
Norman R
NR
Cordell
Geoffrey A
GA
Pezzuto
John M
JM
Kinghorn
A Douglas
AD
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D018520:Plant Shoots / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D034401:Ulmaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes