Comparison of a putative second serotype of chicken infectious anemia virus with a prototypical isolate I. Pathogenesis.
CIAV-7 is a virus with similar pathogenic and physicochemical characteristics to, but antigenically distinct from, chicken infectious anemia virus (CIAV). The pathogenesis of CIAV-7 was evaluated in a comparative study with a representative isolate of CIAV, the Del-Ros strain. The pathogenesis of CIAV-7 was similar to Del-Ros on the basis of the clinical disease induced and gross and microscopic lesions, although CIAV-7 produced fewer and less severe lesions overall. A second comparative pathogenesis study was performed with Del-Ros and CIAV-7, both alone and in combination with infectious bursal disease virus (IBDV). In this study, the pathogenesis of CIAV-7 was similar to Del-Ros in clinical, gross, and microscopic lesions in the bone marrow. However, thymic lesions were less severe in CIAV-7-inoculated birds. The interaction between Del-Ros and IBDV was synergistic, whereas there was no observed potentiation of CIAV-7-induced disease by IBDV. Progeny from breeder flocks from several geographic locations in the eastern United States were challenged with CIAV-7 or Del-Ros to assess protection by maternal antibodies. Some progeny from all flocks had protection against CIAV-7 challenge, providing evidence for the presence of CIAV-7 in the field. Additionally, the number of birds protected against CIAV-7 or Del-Ros challenge varied within flocks, demonstrating that the agents are serologically distinct.
Spackman
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Department of Animal and Food Sciences, 044 Townsend Hall, University of Delaware, Newark, DE 19711, USA.
Cloud
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Pope
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Rosenberger
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JK
D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000821:virology; D017727:Chicken anemia virus / Q000145:classification* / Q000302:isolation & purification / Q000472:pathogenicity; D002645:Chickens / Q000821:virology*; D018173:Circoviridae Infections / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D020022:Genetic Predisposition to Disease; D011201:Poultry Diseases / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D013045:Species Specificity