title: Twenty nuclear DNA polymorphisms in a Moroccan population: a comparison with seven other human populations.
abstract: A south central Moroccan sample was analyzed for 20 nuclear DNA polymorphisms (restriction fragment length polymorphisms). The population was chosen on the basis of available information on its history, making it suitable for comparisons with data from other European populations. The markers analyzed have been studied previously in several human groups from different continents, and data on African and European samples have been compared to evaluate the genetic affinity of the studied sample with other populations, especially with two Spanish groups: Basques and Andalusians. Heterozygosity levels showed intermediate values between the African and European groups and higher than those found so far in an African group for the studied markers. Genetic distances closely matched geographical relationships through neighbor-joining tree and correspondence analysis, the Moroccans being closer to the European groups than the sub-Saharan Africans included in the analysis. Allele distributions revealed specific population associations with large weight of several alleles in the differentiation of some groups. Gene flow from sub-Saharan Africa appears to be relevant in understanding the differentiation of present Moroccan populations.
authors.affiliation: Departamento de Medio Ambiente, Universidad Europea CEES, 28670 Villaviciosa de Odón, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Santander
authors.forename: M
authors.initials: M
authors.lastname: Kandil
authors.forename: F
authors.initials: F
authors.lastname: Luna
authors.forename: P
authors.initials: P
authors.lastname: Moral
mesh_terms: D000349:Africa; D004247:DNA / Q000235:genetics*; D005060:Europe; D005163:Factor Analysis, Statistical; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D008297:Male; D009018:Morocco; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers; D004247:DNA