title: Modular design of artificial transcription factors.
abstract: Eukaryotic transcription factors are composed of interchangeable modules. This has led to the design of a wide variety of modular artificial transcription factors (ATFs) that can stimulate or inhibit the expression of targeted genes. The ability to regulate the expression of any targeted gene using a 'programmable' ATF offers a powerful tool for functional genomics and bears tremendous promise in developing the field of transcription-based therapeutics.
authors.affiliation: Department of Biochemistry and The Genome Center, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Aseem Z
authors.initials: AZ
authors.lastname: Ansari
authors.forename: Anna K
authors.initials: AK
authors.lastname: Mapp
mesh_terms: D001709:Biotechnology / Q000639:trends; D015195:Drug Design; D005057:Eukaryotic Cells / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D023281:Genomics; D006801:Humans; D015202:Protein Engineering / Q000379:methods*; D017434:Protein Structure, Tertiary; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014157:Transcription Factors