title: A preliminary clinical application of sICAM-1 RIA in three kinds of thyroid disease.
abstract: OBJECTIVE
  To examine serum levels of sICAM-1 from normal controls and patients with thyroid diseases (simple goitre, Graves' disease or Hashimoto's thyroiditis) with (125)I-sICAM-1 RIA established in our lab.
  
  
  METHODS
  Using (125)I-sICAM-1 RIA, serum sICAM-1 levels of 400 healthy individuals as the normal group and 1020 patients with simple goitre (SG), Graves' disease (GD) or Hashimoto's thyroiditis (HT) were examined for a comporative chinical study.
  
  
  RESULTS
  The serum level of sICAM-1 (x +/- s) in the normal group was 168.43 +/- 36.23 micro g/L. There was no significant difference between the normal and SG groups (P > 0.05), whereas the serum levels of sICAM-1 in autoimmune thyroid diseases (GD or HT) were higher than those in the normal or SG groups (P < 0.05, respectively). After GD patients received one of three medical treatments, their serum sICAM-1 levels decreased (P < 0.05). After GD patients were treated and their thyroid function decreased to normal, their serum sICAM-1 levels were lower than those in relapsed GD patients (P < 0.05).
  
  
  CONCLUSIONS
  sICAM-1 RIA can be used to examine autoimmune thyroid diseases. Serum levels of sICAM-1 can be used as a parameter in diagnosing autoimmune thyroid disease and in evaluating the effects of therapy, drug administration or relapse in GD.
authors.affiliation: Department of Nuclear Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China. lumei888@yahoo.com
authors.forename: Mei
authors.initials: M
authors.lastname: Lu
authors.forename: Peihua
authors.initials: P
authors.lastname: Fang
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hongpeng
authors.initials: H
authors.lastname: He
authors.forename: Shuo
authors.initials: S
authors.lastname: Gao
authors.forename: Bingzhang
authors.initials: B
authors.lastname: Hou
authors.forename: Rongxiu
authors.initials: R
authors.lastname: Zheng
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006042:Goiter / Q000097:blood* / Q000175:diagnosis; D006111:Graves Disease / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000175:diagnosis
chemical_list: D018799:Intercellular Adhesion Molecule-1