Prospective immunogenicity study of multiple intradermal injections of rabies vaccine in an effort to obtain an early immune response without the use of immunoglobulin.
The present study sought to determine whether increasing and accelerating rabies vaccine administration would result in earlier protective levels of neutralizing antibody. Results indicated that the 8-site and double-dose Thai Red Cross intradermal regimens produced higher antibody titers by day 14 but not significantly higher titers by days 5 and 7. Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment.
Khawplod
Pakamatz
P
World Health Organization Collaborating Center for Research in Rabies, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
Wilde
Henry
H
Tepsumethanon
Saovaluk
S
Limusanno
Sukunya
S
Tantawichien
Tanpetch
T
Chomchey
Pranee
P
Ayuthaya
Ampai Bungjongkasaena Na
AB
Wangroonsarb
Yongyuth
Y
D000328:Adult; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity; D007271:Injections, Intradermal; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000906:Antibodies; D011819:Rabies Vaccines