title: Specific interactions of complementary mono- and multivalent guests with recognition-induced polymersomes.
abstract: We have explored the interactions of mono- and multivalent guests with Recognition-Induced Polymersomes (RIPs) formed from complementary random copolymers featuring diamidopyridine and thymine functionality. Addition of monovalent guests featuring imide functionality to these RIPs induced a temporary swelling of the vesicles, followed by dissociation of the vesicles due to competitive binding of the guest. Conversely, multivalent thymine-functionalized nanoparticle guests were rapidly incorporated into the RIPs, inducing a contraction of RIP diameter over time. These mono- and multivalent interactions were extremely specific: highly analogous control systems showed no interaction with the RIP structures. Taken together, these studies demonstrate highly selective molecular "lock and key" control over higher-order assembly and recognition processes.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Thibault
authors.forename: Trent H
authors.initials: TH
authors.lastname: Galow
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Turnberg
authors.forename: Mark
authors.initials: M
authors.lastname: Gray
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hotchkiss
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D001667:Binding, Competitive; D040761:Biomimetic Materials / Q000737:chemistry; D005415:Flavins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013379:Substrate Specificity; D013941:Thymine / Q000737:chemistry*
chemical_list: D005415:Flavins; D007094:Imides; D011108:Polymers; D011725:Pyridines; D006046:Gold; D013941:Thymine