Soluble leptin receptor levels in patients with anorexia nervosa.
OBJECTIVE
To examine whether changes of serum soluble leptin receptor levels (S-LEPR) can modify leptin half-life and its tissue effects. The aim of our study was to measure S-LEPR levels in patients with anorexia nervosa (AN) before and 6 weeks after partial refeeding.


METHODS
Anthropometric variables, serum leptin, S-LEPR, insulin, cortisol and TNF-alpha were measured in 15 AN patients before and after partial refeeding and 15 healthy control women.


RESULTS
S-LEPR levels in AN patients were significantly higher than in healthy subjects (26.8 +/- 8.1 vs. 16.36+/-2.6U/mL, p < 0.01) and were not affected by partial refeeding (26.8 +/- 8.1 vs. 24.2 +/- 6.1 U/mL). In contrast, body mass index (BMI), body fat content, and serum leptin levels in AN patients increased significantly after partial refeeding. Except for the inverse relationship of S-LEPR levels to BMI and body fat content no clear relationship of this parameter to serum leptin, cortisol, insulin or TNF-alpha was found.


CONCLUSIONS
S-LEPR levels are significantly increased in AN patients and this increase is unaffected by partial refeeding. The possibility of etiological role of increased S-LEPR levels in AN patients by affecting leptin central and/or peripherial effects should be further elucidated.
Krizova
Jarmila
J
3rd Department of Medicine, 1st Medical Faculty, Charles University, U Nemocnice 1, Prague 2, 128 08, Czech Republic. jsvob@email.cz
Papezova
Hana
H
Haluzikova
Denisa
D
Parizkova
Jitka
J
Jiskra
Jan
J
Kotrlikova
Eva
E
Haas
Tomas
T
Haluzik
Martin
M
D000273:Adipose Tissue / Q000473:pathology; D000856:Anorexia Nervosa / Q000097:blood* / Q000473:pathology; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D005502:Food; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D011956:Receptors, Cell Surface / Q000097:blood* / Q000737:chemistry; D054411:Receptors, Leptin; D012016:Reference Values; D012995:Solubility
D007328:Insulin; C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin