A novel degradable polycaprolactone networks for tissue engineering.
Polycaprolactone (PCL) macromer was obtained by the reaction of PCL diol with acryloyl chloride and confirmed using Fourier transform infrared and nuclear magnetic resonance spectrometer. Novel degradable PCL networks were prepared through photopolymerization of the PCL macromer. Thermal, mechanical, and morphological characteristics as well as degradability and biocompatibility of the PCL networks were investigated. Differential scanning calorimetry showed that the melting temperature and the calculated weight average crystallinity of PCL networks were decreased with a decrease of molecular weight of PCL diols due to the increased crosslinking density. Thermal stability of PCL networks was higher than that of PCL diols. PCL networks showed faster degradation, and higher compressive modulus and compressive recovery ratios than those of PCL itself because of their low crystallinity and the modification of terminal groups. The porosity of the PCL networks can be controlled by the amounts and size of porogen used. MG-63 osteoblast cell was attached and proliferated on PCL networks. PCL networks therefore may have considerable potential as scaffold for tissue engineering.
Kweon
HaeYong
H
Department of Sericulture and Entomology, National Institute of Agriculture and Technology, Suwon 441-100, South Korea.
Yoo
Mi Kyong
MK
Park
In Kyu
IK
Kim
Tae Hee
TH
Lee
Hyun Chul
HC
Lee
Hyun-Sook
HS
Oh
Jong-Suk
JS
Akaike
Toshihiro
T
Cho
Chong Su
CS
D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002151:Calorimetry; D002460:Cell Line; D004548:Elasticity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010006:Osteoblasts / Q000378:metabolism*; D011091:Polyesters / Q000737:chemistry* / Q000493:pharmacokinetics*; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013816:Thermodynamics; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone