Retinal nerve fiber layer measurement of the Hong Kong chinese population by optical coherence tomography.
OBJECTIVE
To obtain retinal nerve fiber layer (RNFL) measurements by optical coherence tomography in a local, normal Hong Kong Chinese population and to identify the correlation of the measurement with age cross-sectionally.


METHODS
A total of 129 normal Hong Kong Chinese volunteers of different age groups were recruited for this study. The RNFL was measured by optical coherence tomography (OCT; OCT 2000; Humphrey Instruments, San Leandro, CA).


RESULTS
Mean +/- SD peripapillary RNFL measurements at the superior, inferior, temporal, and nasal regions were 145 +/- 24, 154 +/- 26, 98 +/- 32, and 87 +/- 16 microm, respectively. There was a highly significant negative correlation in average RNFL measurement with increasing age (3.3 microm per decade, < 0.001). A significant negative correlation with increasing age was also identified in the RNFL measurements in all the regions ( < 0.05) and decreased at similar extent.


CONCLUSIONS
The RNFL thickness of the Hong Kong Chinese population, as measured by OCT, appeared to decrease over time. The OCT normative values used for determining RNFL measures "outside of normal" should be developed on an age-specific, or at least age-adjusted, basis.
Mok
Kwok Hei
KH
Eye Center, Hong Kong Adventist Hospital, Department of Anatomy, The University of Hong Kong, Hong Kong. akhmok@hkah.org.hk
Lee
Vincent Wing-Hong
VW
So
Kwok Fai
KF
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D044466:Asian People; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007368:Interferometry; D008027:Light; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009900:Optic Nerve / Q000033:anatomy & histology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D014054:Tomography / Q000379:methods