title: MPO-ANCA-associated pulmonary-renal vasculitis in a patient with diabetes mellitus.
abstract: Diabetes mellitus is one of the major causes of chronic renal failure. Typical findings of diabetic nephropathy are early hyperfiltration followed by microalbuminuria and overt proteinuria, resulting in a progressive decrease in glomerular filtration rate. Rapidly progressive glomerulonephritis has rarely been reported in patients with diabetes mellitus. Here, we describe a patient with MPO-ANCA-associated vasculitis, presenting with pulmonary-renal syndrome. Immunosuppressive treatment, including pulse methyl-prednisolone and cyclophosphamide, was administered and the disease was resolved.
authors.affiliation: Ankara University Medical School, Department of Nephrology, Ibni Sina Hospital, Ankara, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Keven
authors.forename: Harun
authors.initials: H
authors.lastname: Akar
authors.forename: Sim
authors.initials: S
authors.lastname: Kutlay
authors.forename: Gokhan
authors.initials: G
authors.lastname: Nergizoglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Erbay
authors.forename: Sehsuvar
authors.initials: S
authors.lastname: Erturk
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis / Q000276:immunology*; D003520:Cyclophosphamide / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis / Q000276:immunology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013577:Syndrome; D016896:Treatment Outcome; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D009195:Peroxidase; D008775:Methylprednisolone