title: Incidental diagnosis and tempestive therapy in a case of neonatal alloimmune thrombocytopenia due to anti-HPA-5b.
abstract: Neonatal alloimmune thrombocytopenia (NAIT) is usually attributable to HPA-1a antibodies. The authors report a case of incidentally diagnosed thrombocytopenia in a small for gestational age infant. A NAIT was suspected and she was successfully treated with intravenous IgG. The direct and indirect platelet suspension immunofluorescence test (PSIFT) in maternal blood suggested alloimmunization to HPA-5b. Empiric treatment with IgG could be useful in case of clear suspect even in absence of confirmed diagnosis.
authors.affiliation: Department of Pediatrics, Catholic University of Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
authors.forename: Antonio Alberto
authors.initials: AA
authors.lastname: Zuppa
authors.forename: Francesco
authors.initials: F
authors.lastname: Cota
authors.forename: Daniele
authors.initials: D
authors.lastname: De Luca
authors.forename: Federica
authors.initials: F
authors.lastname: Visintini
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: De Turris
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tortorolo
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D005331:Fetomaternal Transfusion; D015200:Fluoroimmunoassay; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology*
chemical_list: C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies