Diastereoselective synthesis of highly substituted tetrahydropyran-4-ones.
[reaction: see text] Aldol reactions of beta-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.
Clarke
Paul A
PA
School of Chemistry, University of Nottingham, University Park, United Kingdom. paul.clarke@nottingham.ac.uk
Martin
William H C
WH