title: Germinoma with a granulomatous reaction. Problems of differential diagnosis.
abstract: The patient was a 6 year-old girl with a progressive loss of visual acuity. Magnetic resonance imaging showed a suprasellar mass lesion with enhanced gadolinium which was resected. Histopathological study showed a remarkable granulomatous reaction, but a diagnosis was difficult. However, immunohistochemical study showed a few cells that were positive for placental alkaline phosphatase and it was diagnosed as germinoma. Intracranial germinoma with a remarkable granulomatous reaction is rare. However, when germinoma is suspected clinically, an immunohistochemical study is able to identify germinoma even if granulomatous disease is diagnosed histopathologically.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Konno
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Utsuki
authors.forename: K
authors.initials: K
authors.lastname: Kondou
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: S
authors.initials: S
authors.lastname: Yagishita
mesh_terms: D000469:Alkaline Phosphatase; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D058851:GPI-Linked Proteins; D018237:Germinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006099:Granuloma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism; D008279:Magnetic Resonance Imaging
chemical_list: D000970:Antineoplastic Agents; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D005047:Etoposide; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental; D002945:Cisplatin