Effects of the anti-ulcer agents ecabet sodium, cimetidine and sucralfate on acetylsalicylic acid-induced gastric mucosal damage deteriorated by renal failure in rats.
Renal failure including post-renal transplantation increases the susceptibility of the upper gastrointestinal mucosa to injury. The aim of this study was to confirm the influence of renal failure on gastric mucosal barrier and the protective effect of various anti-ulcer agents in rats. Renal failure (RF) was induced by 45-min left renal artery clamping and right-uninephrectomy. Four days after surgery, gastric mucosal lesions were induced by intragastric administration of acetylsalicylic acid (ASA, CAS 50-78-2) (100 mg/kg). Anti-ulcer agents were given orally 30 min before ASA administration. RF induced moderate gastric mucosal damages, but significantly worsened the ASA-induced gastric lesions. Ecabet sodium (CAS 86408-72-2) and cimetidine (CAS 51481-61-9) significantly inhibited ASA-induced gastric lesions in RF rats, whereas sucralfate (CAS 54182-58-0) tended to inhibit it. ASA and all of these anti-ulcer agents had no effect on the serum creatinine and blood urea nitrogen levels increased by RF. The gastric mucosa of RF rats is more susceptible to damage induced by ASA. Ecabet and cimetidine potently inhibited gastric lesions in RF rats suggesting its utility for the gastric mucosal damage in patients with RF including post-renal transplant.
Nogi
Koji
K
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Kawagishi, Toda, Saitama, Japan. K-nogi@tanabe.co.jp
Taniguchi
Hiroyuki
H
Onoda
Yuichi
Y
D045784:Abietanes; D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin; D001806:Blood Urea Nitrogen; D002927:Cimetidine / Q000494:pharmacology*; D018450:Disease Progression; D004224:Diterpenes / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D007677:Kidney Function Tests; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control*; D013392:Sucralfate / Q000494:pharmacology*
D045784:Abietanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D004224:Diterpenes; C061681:ecabet; D013392:Sucralfate; D002927:Cimetidine; D001241:Aspirin