One ring to bind them. Septins and actin assembly.
Septins are GTPases required for cytokinesis and other processes requiring spatial organization of the cell cortex, but their molecular functions in these processes are unknown. In this issue of Developmental Cell, Kinoshita et al. take an important step in elucidating the molecular functions of septins by developing an in vitro assay for septin assembly and exploring the relationship between mammalian septins and actin.
Finger
Fern P
FP
Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison 53706, USA.
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D003285:Contractile Proteins / Q000378:metabolism; D003598:Cytoskeletal Proteins; D005057:Eukaryotic Cells / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D058112:Septins; D015003:Yeasts / Q000378:metabolism / Q000648:ultrastructure
D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; C095886:anillin; D019204:GTP-Binding Proteins; C436485:SEPTIN6 protein, human; D058112:Septins