title: [The relationship between haplotypes of angiotensinogen gene and essential hypertension].
abstract: OBJECTIVE
  To investigate the relationship between the polymorphism of angiotensinogen gene (AGT) and the risk for hypertension in a Chinese population.
  
  
  METHODS
  Three polymorphisms of AGT gene were analyzed in 335 patients with documented essential hypertension and 196 control subjects by using PCR-restriction fragment length polymorphism. Expectation maximization(EM) algorithm was then used for pairwise linkage disequilibrium test and haplotype analysis of AGT polymorphisms.
  
  
  RESULTS
  Linkage disequilibrium between M235T and A-20C, between M235T and A-6G, between A-20C and A-6G was observed (P<10(-4)). The case-control analysis revealed that the frequency of T235 is significantly higher in essential hypertension patients than in control subjects. But all haplotype frequencies showed no significant difference between the patient and control groups.
  
  
  CONCLUSIONS
  No association was noted between the haplotypes of AGT gene and hypertension in tested people, but T235 allele might play an important role in increased risk for essential hypertension.
authors.affiliation: Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Kong
authors.forename: Sizhong
authors.initials: S
authors.lastname: Zhang
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Yang
authors.forename: Keqin
authors.initials: K
authors.lastname: Zheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Tong
authors.forename: Jiajun
authors.initials: J
authors.lastname: Shi
authors.forename: Kelan
authors.initials: K
authors.lastname: Zhang
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Su
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
mesh_terms: D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D000808:Angiotensinogen; D004247:DNA