title: Impact of meningococcal vaccination with combined serogroups A and C polysaccharide vaccine on carriage of Neisseria meningitidis C.
abstract: Two studies of meningococcal carriage state were carried out in Galicia (Spain) before and after a mass vaccination campaign between December 1996 and January 1997 against Neisseria meningitidis serogroup C with meningococcal serogroups A and C polysaccharide vaccine. The studies covered two areas with different incidence rates of meningococcal disease in 1996 (high and low incidence). Carriage rates of serogroup C showed a decrease in both areas, 47 and 65 % respectively, before and after the vaccination. Results showed a decrease in carrier state in the age groups 10-14- and 15-19-year-olds, but not in the 5-9-year-olds. These results demonstrate the effect of immunization on the reduction of the carriage state.
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Fernández
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Arreaza
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Santiago
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Malvar
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Berrón
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Vazquez
authors.affiliation: Dirección Xeral de Saúde Pública, Consellería de Sanidade, 15771 Santiago de Compostela, Galicia, Spain 2Laboratorio de Neisserias, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Hervada
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology*; D038381:Neisseria meningitidis, Serogroup A / Q000276:immunology* / Q000302:isolation & purification; D038542:Neisseria meningitidis, Serogroup C / Q000276:immunology* / Q000302:isolation & purification; D013030:Spain / Q000453:epidemiology; D014611:Vaccination
chemical_list: D022401:Meningococcal Vaccines