[Clinico-immunologic subtypes of type I diabetes mellitus].
OBJECTIVE
To study clinico-immunological characteristics of diabetes mellitus type I.


METHODS
Clinical examination was made of 333 patients with diabetes mellitus type I with manifestation of carbohydrate metabolism impairment and intoxication syndrome because of diabetic ketoacidosis (group 1) and without it (group 2). Compared to donors (n = 68), T-cell, B-cell and monocytic components of immune system were studied in patients with uncomplicated DM type 1 in both groups (28 and 15 patients, respectively).


RESULTS
Patients with different subtypes of the disease differ by the course and rate of progression, defects in T-cell and monocyte components of immunity.


CONCLUSIONS
Type 1 diabetes mellitus is a heterogenous pathology with subtype 1 (rapidly progressive) and subtype 2 (slowly progressive).
Zhuk
E A
EA
Galenok
V A
VA
D000293:Adolescent; D000328:Adult; D050260:Carbohydrate Metabolism; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000276:immunology / Q000473:pathology; D016883:Diabetic Ketoacidosis / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology