Human herpesvirus 6B infection of the large intestine of patients with diarrhea.
Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.
Amo
Kiyoko
K
Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. kiyokoamo@pop12.odn.ne.jp
Tanaka-Taya
Keiko
K
Inagi
Reiko
R
Miyagawa
Hiromi
H
Miyoshi
Hiroko
H
Okusu
Ikuko
I
Sashihara
Junji
J
Hara
Junichi
J
Nakayama
Masahiro
M
Yamanishi
Koichi
K
Okada
Shintaro
S
D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000503:physiopathology / Q000821:virology*; D007420:Intestine, Large; D008297:Male; D019349:Roseolovirus Infections / Q000503:physiopathology / Q000821:virology*; D033581:Stem Cell Transplantation