title: Recombinant plasminogen activator therapy for cerebral vein thrombosis in a child carrier of prothrombin gene mutation.
abstract: Venous thrombosis of transverse and sigmoid sinuses was diagnosed in a 3-year-old child who is a carrier of the G20210A prothrombin gene mutation. Recombinant tissue plasminogen activator (rt-PA) treatment was started 9 days following the onset of neurologic signs. Nine days of rt-PA therapy completely dissolved the thrombus. This case provides further evidence that rt-PA is useful and safe in children with thrombosis.
authors.affiliation: Department of Pediatrics, La Sapienza University, viale Regina Elena 324, 00161 Rome, Italy. luitarani@tiscalinet.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Tarani
authors.forename: Metello
authors.initials: M
authors.lastname: Iacobini
authors.forename: Valerio
authors.initials: V
authors.lastname: De Stefano
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Smacchia
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Tozzi
authors.forename: Grazia
authors.initials: G
authors.lastname: Raguso
authors.forename: Lida
authors.initials: L
authors.lastname: Bruni
mesh_terms: D001921:Brain / Q000473:pathology; D002550:Cerebral Veins; D002675:Child, Preschool; D006580:Genetic Carrier Screening; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010960:Plasminogen Activators / Q000627:therapeutic use; D011516:Prothrombin / Q000235:genetics*; D011994:Recombinant Proteins / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000235:genetics
chemical_list: D011994:Recombinant Proteins; D011516:Prothrombin; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator