title: Internal papillomatosis with intrahepatic cholangiocarcinoma and gastrointestinal adenocarcinoma in a peach-fronted conure (Aratinga aurea).
abstract: A 17-yr-old pet female peach-fronted conure (Aratinga aurea) was presented with the chief complaints of mild lethargy and weight loss with increased appetite. Antemortem diagnostics included complete blood count, plasma biochemistry, and radiography. Abnormal findings included elevated inflammatory parameters (hyperfibrinogenemia) and a space-occupying mass in the region of the liver. Histologic examination of a liver biopsy sample indicated bile duct hyperplasia leading to a presumptive diagnosis of hepatoxicosis. The bird initially showed moderate improvement with supportive care, but its condition declined 9 days after the liver biopsy. Supportive care was attempted a second time, but the bird did not improve and euthanasia was elected. Abnormal gross necropsy findings were confined to the liver, which contained multiple tan nodules that exuded yellowish fluid on cut section. Histopathologic examination revealed multicentric bile duct hyperplasia and cholangiocarcinoma as well as segmental papillary hyperplasia and adenocarcinoma in the proventriculus, ventriculus, and throughout the intestinal tract. This is the first report of concurrent internal papillomatosis, gastrointestinal adenocarcinoma, and cholangiocarcinoma in a peach-fronted conure.
authors.affiliation: Companion Avian and Exotic Pet Medicine Service, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Gibbons
authors.forename: Martin D
authors.initials: MD
authors.lastname: Busch
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Tell
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Graham
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001715:Bird Diseases / Q000473:pathology; D018281:Cholangiocarcinoma / Q000473:pathology / Q000662:veterinary*; D037901:Euthanasia, Animal; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000662:veterinary*; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D010212:Papilloma / Q000473:pathology / Q000662:veterinary*; D011563:Psittaciformes