Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin chemotherapy.
BACKGROUND
Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin therapy is a previously unreported complication.


METHODS
A 63-year-old woman with stage Ib2 squamous cell carcinoma of the cervix was treated with intraarterial cisplatin infusion in a neoadjuvant setting. Four days following the second course of chemotherapy, she became drowsy with severe fatigue and decreased mental awareness. Blood tests showed sodium of 110 mEq/L. Urine and plasma osmolarities were 308 and 240 mOsm/kg, respectively, confirming the diagnosis of a syndrome of inappropriate secretion of antidiuretic hormone induced by intra-arterial cisplatin infusion.


CONCLUSIONS
The potential for development of clinically significant hyponatremia early in the course of cisplatin therapy with any infusion routes emphasizes the need to closely monitor patients.
Ishii
Keisuke
K
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi dori, Niigata 951-8510, Japan.
Aoki
Yoichi
Y
Sasaki
Masaru
M
Tanaka
Kenichi
K
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D007269:Injections, Intra-Arterial; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000188:drug therapy
D000970:Antineoplastic Agents; D002945:Cisplatin