title: Cystic appearance of cervical lymph nodes is characteristic of metastatic papillary thyroid carcinoma.
abstract: OBJECTIVE
  The usefulness of high-resolution sonography in diagnosing cervical lymph node metastases from papillary thyroid carcinoma was investigated. The accuracy of a particular sign, cystic change within a node, in establishing the diagnosis was assessed.
  
  
  METHODS
  The sonographic findings in 63 patients with enlarged cervical lymph nodes were retrospectively reviewed. The patients had undergone high-resolution gray-scale and color Doppler sonography followed by ultrasound-guided fine-needle aspiration (FNA) in all patients and surgical excision in 27 patients.
  
  
  RESULTS
  Abnormal sonographic features were present in the lymph nodes of all 63 patients. In 14 (70%) of 20 patients with papillary thyroid carcinoma, sonography depicted cystic changes. This pattern was not found in any of the other 43 patients, in whom FNA revealed either metastasis from another malignancy (22 patients) or benign reactive lymphadenopathy (21 patients). Among the 63 patients, there were 43 true-negative, 14 true-positive, 6 false-negative, and no false-positive results in the diagnosis of metastatic papillary thyroid carcinoma using the presence or absence of an intranodal cystic area on sonography. These results yielded a 70% sensitivity, 100% specificity, 100% positive predictive value, 88% negative predictive value, and 90% overall accuracy for this criterion.
  
  
  CONCLUSIONS
  Cystic changes within a cervical lymph node are highly suggestive of metastatic papillary thyroid carcinoma.
authors.affiliation: Department of Radiology-Ultrasound Division, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
authors.forename: Ada
authors.initials: A
authors.lastname: Kessler
authors.forename: Yoram
authors.initials: Y
authors.lastname: Rappaport
authors.forename: Annat
authors.initials: A
authors.lastname: Blank
authors.forename: Sylvia
authors.initials: S
authors.lastname: Marmor
authors.forename: Judith
authors.initials: J
authors.lastname: Weiss
authors.forename: Moshe
authors.initials: M
authors.lastname: Graif
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009333:Neck; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018615:Ultrasonography, Doppler, Color