title: Diastereoselective synthesis of highly substituted tetrahydropyran-4-ones.
abstract: [reaction: see text] Aldol reactions of beta-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, United Kingdom. paul.clarke@nottingham.ac.uk
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clarke
authors.forename: William H C
authors.initials: WH
authors.lastname: Martin