title: Spontaneous recanalization of arterial occlusions: an unusual mechanism for symptomatic improvement.
abstract: OBJECTIVE
  Patients with infrainguinal occlusive disease may experience spontaneous symptomatic improvement. This is generally thought to be from augmented collateral circulation. This study reports another mechanism.
  
  
  METHODS
  Over a 20-year period, 4123 patients underwent lower extremity arteriography for limb ischemia. For a variety of reasons, 451 patients had repeat arteriography.
  
  
  RESULTS
  Five patients were identified as having conclusive arteriographic evidence of spontaneous recanalization of occluded arterial segments without having undergone any surgical or thrombolytic interventions. Repeat contrast arteriography was performed on these patients for failing grafts (n = 2) or contralateral lower extremity ischemia (n = 3). Three other patients had magnetic resonance arteriographic or duplex arteriographic evidence of spontaneous arterial recanalization. Spontaneous recanalizaton occurred in ileofemoral (n = 2), superficial femoral (n = 2), popliteal (n = 3), and peroneal (n = 1) arterial segments. The average time interval of occlusion to recanalization was 21 weeks (2 weeks to 2 years). Two of the eight patients had failed revascularization procedures before spontaneous recanalization. All eight patients had restoration of pulses distal to the recanalized segments and significant symptomatic improvement as defined with the Society for Vascular Surgery/American Association for Vascular Surgery categories for limb ischemia.
  
  
  CONCLUSIONS
  Spontaneous recanalization of arterial segments can occur and must be considered when evaluating other proposed treatments of critical limb ischemia, including cilostazol, lytic agents, and angiogenic agents, such as vascular endothelial growth factor. Although its true incidence is unknown, this represents another mechanism for spontaneous symptomatic improvement without treatment in patients with severe limb ischemia.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E. 210th Street, New York, NY 10467, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Gargiulo
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Veith
authors.forename: Evan C
authors.initials: EC
authors.lastname: Lipsitz
authors.forename: Takao
authors.initials: T
authors.lastname: Ohki
authors.forename: William D
authors.initials: WD
authors.lastname: Suggs
authors.forename: Neal S
authors.initials: NS
authors.lastname: Cayne
authors.forename: Nishan
authors.initials: N
authors.lastname: Dadian
authors.forename: Reese A
authors.initials: RA
authors.lastname: Wain
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001775:Blood Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D007264:Inguinal Canal / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007511:Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012720:Severity of Illness Index