Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon.
We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.
Borrelli
F
F
Department of Experimental Pharmacology, University of Naples 'Federico II', Via D. Montesano 49, 80131, Naples, Italy. franborr@unina.it
Izzo
A A
AA
Di Carlo
G
G
Maffia
P
P
Russo
A
A
Maiello
F M
FM
Capasso
F
F
Mascolo
N
N
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001397:Azoxymethane; D002109:Caffeic Acids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011429:Propolis / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D016588:Anticarcinogenic Agents; D002109:Caffeic Acids; D010936:Plant Extracts; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D001397:Azoxymethane