The effect of repeated leishmanin skin testing on the immune responses to Leishmania antigen in healthy volunteers.
The leishmanin skin test (LST) is used in immunogenicity studies. The effect of multiple LSTs on immune responses was assessed. None of the volunteers converted to LST positive. IFN-gamma and IL-10 levels remained unchanged. Repetition of LST does not modulate the in vivo or in vitro immune responses to Leishmania antigen.
Satti
Iman
I
Microbiology and Tumour Biology Centre, Karolinska Institute, Box 280, S-171 77 Stockholm, Sweden.
el Hassan
Ahmed
A
Khalil
El Tahir A G
el TA
Akuffo
Hannah
H
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D006801:Humans; D007891:Leishmania / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology*; D012882:Skin Tests / Q000379:methods; D013397:Sudan
D000953:Antigens, Protozoan; C032127:leishmanin