Moving across membranes.
Protein toxins are known to translocate through intracellular membranes to reach their cytosolic targets. Results from studies with botulinum neurotoxin suggest that the toxin heavy chain functions as both a channel and a chaperone for translocation of the catalytically active light chain.
Neale
Elaine A
EA
D000818:Animals; D001905:Botulinum Toxins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D009498:Neurotoxins / Q000737:chemistry / Q000378:metabolism; D021381:Protein Transport
D009498:Neurotoxins; D001905:Botulinum Toxins