Leukemic cell insensitivity to cyclophosphamide and other oxazaphosphorines mediated by aldehyde dehydrogenase(s).
Sládek
Norman E
NE
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
D000444:Aldehyde Dehydrogenase / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D010078:Oxazines / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; D010078:Oxazines; D003520:Cyclophosphamide; D000444:Aldehyde Dehydrogenase