Extreme self-organization in networks constructed from gene expression data.
We study networks constructed from gene expression data obtained from many types of cancers. The networks are constructed by connecting vertices that belong to each others' list of K nearest neighbors, with K being an a priori selected non-negative integer. We introduce an order parameter for characterizing the homogeneity of the networks. On minimizing the order parameter with respect to K, degree distribution of the networks shows power-law behavior in the tails with an exponent of unity. Analysis of the eigenvalue spectrum of the networks confirms the presence of the power-law and small-world behavior. We discuss the significance of these findings in the context of evolutionary biological processes.
Agrawal
Himanshu
H
Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel. feagrawa@wicc.weizmann.ac.il
D000230:Adenocarcinoma / Q000235:genetics*; D000465:Algorithms; D001943:Breast Neoplasms / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics*; D003627:Data Interpretation, Statistical; D020869:Gene Expression Profiling; D006801:Humans; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis