title: [MR aortofemorography versus DSA: prospective evaluation].
abstract: OBJECTIVE
  To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA.
  
  
  METHODS
  Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively compared to DSA in 49 consecutive patients (40 males, 9 females; age range 38-80 years; mean age 64 years). According to Leriche and Fontaine's clinical gradation of lower limb ischemia, 5 patients were graded I, 37 graded II, 4 graded III, and 3 graded IV. Two observers graded stenoses for DSA and three for MRA. Cohen's kappa statistics were used to evaluate interobserver variability using MRA, as well as to compare MRA to DSA. In addition, sensitivity, specificity, positive and negative predictive values of MRA for the assessment of stenosis superior to 80% were calculated by using DSA as a gold standard, respectively for arterial trunks above and below the level of the knees.
  
  
  RESULTS
  Overall accuracy of MRA was 92%. Comparison of DSA and MRA yielded a kappa value of 0.87 (0.95 for arterial trunks located above the level of the knees and 0.75 below). Interobserver agreement was very good. Sensitivity, specificity, positive and negative predictive values of MRA for the diagnosis of > 80% stenosis were respectively 98, 98, 85 and 99% above the level of the knees and 87, 91, 77 and 96% below the knees.
  
  
  CONCLUSIONS
  MRA can be considered as valuable technique for the evaluation of peripheral arterial obstructive disease, especially for stenosis located above the level of the knees.
authors.affiliation: Service d'lmagerie Médicale, Les Cliniques Saint-Joseph, Liège, Belgique.
authors.forename: A
authors.initials: A
authors.lastname: Nchimi
authors.forename: D
authors.initials: D
authors.lastname: Brisbois
authors.forename: E
authors.initials: E
authors.lastname: Donkers
authors.forename: J F
authors.initials: JF
authors.lastname: Biquet
authors.forename: C
authors.initials: C
authors.lastname: Saive
authors.forename: A
authors.initials: A
authors.lastname: Jadot
authors.forename: R
authors.initials: R
authors.lastname: Magotteaux
mesh_terms: D015901:Angiography, Digital Subtraction; D001012:Aorta, Abdominal / Q000473:pathology; D001027:Aortography; D001161:Arteriosclerosis / Q000175:diagnosis*; D005263:Femoral Artery / Q000473:pathology; D006801:Humans; D007511:Ischemia / Q000175:diagnosis*; D007717:Knee / Q000098:blood supply; D007866:Leg / Q000098:blood supply*; D018810:Magnetic Resonance Angiography; D015588:Observer Variation; D011446:Prospective Studies; D012680:Sensitivity and Specificity