Ergot and triptan overuse in Austria--an evaluation of clinical data and cost.
Austria is one of the countries, in which ergots are still the most commonly used acute anti-migraine drugs. Overuse and chronification is a clinical problem for ergots, but also for the recently developed triptans. In a retrospective study for the year 1999 we evaluated clinical data from all Austrian neurological hospitals including cost of withdrawal as well as the estimated cost for ergots and triptans on the pharmaceutical retail market. We identified a total of 96 patients that underwent withdrawal, all of whom because of ergot overuse, and some with considerable long-term side-effects. The cost of withdrawal (more than 1300 000) together with direct cost of medication amounted to more than 11 million. In contrast, cost of medication for triptans was 12.8 million for the same year, without any cost for withdrawal. If only cost aspects were to be considered in the prescription of acute anti-migraine drugs, our data would suggest to choose ergots rather than triptans. However, as scientific evidence is clearly in favour of triptans, decision making for the prescribing clinicians is more complex and will primarily focus on optimizing patient care, but also depend on the respective socio-economic situation.
Lampl
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C
Department of Neurology, Psychiatry and Pain Centre, General Hospital Linz, Linz, Austria. christian.lampl@akh.linz.at
Buzath
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A
Yazdi
K
K
Sandor
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PS
D000328:Adult; D000368:Aged; D001317:Austria / Q000453:epidemiology; D004876:Ergot Alkaloids / Q000009:adverse effects* / Q000191:economics* / Q000627:therapeutic use; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000191:economics; D006801:Humans; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000191:economics*; D019966:Substance-Related Disorders / Q000191:economics / Q000453:epidemiology; D018170:Sumatriptan / Q000009:adverse effects* / Q000191:economics* / Q000627:therapeutic use; D014363:Tryptamines
D004876:Ergot Alkaloids; D023303:Oxazolidinones; D014363:Tryptamines; C089750:zolmitriptan; D018170:Sumatriptan