Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice.
It is known that retinally degenerate C57BL/6J (rd/rd) mice have unattenuated circadian photosensitivity. However, the authors have previously found that CBA/J (rd/rd) mice that carry the same rd mutation have attenuated circadian photosensitivity compared to normal CBA/N (+/+) mice. In the present study, a quantitative trait locus (QTL) analysis using C57BL/6J (rd/rd) and CBA/J (rd/rd) mice was conducted in order to identify the genes affecting circadian photosensitivity of the rd mice. As a result, several putative QTLs onthree separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes. Identification of these genes may provide new insights into the understanding of regulation of circadian photoentrainment and sleep-wake disorders.
Yoshimura
Takashi
T
Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. takashiy@agr.nagoya-u.ac.jp
Yokota
Yuki
Y
Ishikawa
Akira
A
Yasuo
Shinobu
S
Hayashi
Noriko
N
Suzuki
Tohru
T
Okabayashi
Naritoshi
N
Namikawa
Takao
T
Ebihara
Shizufumi
S
D000818:Animals; D002874:Chromosome Mapping; D002940:Circadian Rhythm / Q000528:radiation effects*; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010787:Photosensitivity Disorders / Q000235:genetics* / Q000503:physiopathology; D040641:Quantitative Trait Loci; D012162:Retinal Degeneration / Q000235:genetics*