Single photon emission computerized tomography in children with developmental language disorder--a preliminary report.
Developmental language disorder (DLD) is a diagnosis given to a nonautistic child who has inadequate language acquisition despite adequate hearing, sensorimotor, and cognitive skills. We used high-resolution single photon emission computerized tomography (SPECT) with labeled technetium-99m-D, L-hexamethyl-propylene amine oxime (99mTc-HMPAO) to measure regional cerebral blood flow (rCBF) in 11 children with DLD. Their mean age was 5 years 10 months (range, 4 yr 2 mo to 10 yr 9 mo) and mean nonverbal IQ was 107 (range, 82-137). When inter-hemispheric flow discrepancy was defined as a bilateral rCBF difference of more than 10%, 10 children (90.9%) had discrepant blood flow. Temporal lobes were involved in all 10 children: lateral-temporal in five, medial-temporal in four, and mesial-temporal in four. Though the study was small and the results are preliminary, results suggest that DLD may be a consequence of an underlying neurobiologic problem in areas of the brain known to be involved with language.
Lee
Bi-Fang
BF
Department of Nuclear Medicine, National Cheng Kung University Hospital, Tainan.
Yang
Pinchen
P
Jong
Yuh-Jyh
YJ
Hsu
Hsiu-Yi
HY
Chen
Cheng-Chung
CC
D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007805:Language Development Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D019690:Technetium Tc 99m Exametazime