title: A new strategy toward the total synthesis of stachyflin, a potent anti-influenza A virus agent: concise route to the tetracyclic core structure.
abstract: [reaction: see text] A new strategy directed toward the total synthesis of stachyflin, a potent and novel anti-influenza A virus agent isolated from a microorganism, has been presented through the enantioselective synthesis of the tetracyclic core structure. The synthetic method features a BF(3) x Et(2)O-induced domino epoxide-opening/rearrangement/cyclization reaction as the key step.
authors.affiliation: Sagami Chemical Research Center, Hayakawa 2743-1, Ayase, Kanagawa 252-1193, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Nakatani
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Suzuki
authors.forename: Munenori
authors.initials: M
authors.lastname: Inoue
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katoh
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D009980:Influenza A virus; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013191:Stachybotrys / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D012717:Sesquiterpenes; C120519:stachyflin