Effects of various applications of lipopolysaccharides on blood parameters of pigs.
In five experiments, lipopolysaccharides (LPS) of Escherichia coli O26:B6 and O111:B4 were applied intravenously, intramuscularly, subcutaneously or intrabronchially in doses of 5000-15,000 U/kg body mass to a total of 47 weaner pigs and compared with the application of sodium chloride. Different parameters of blood cells were investigated, including cell numbers, in vivo interleukin secretion, radical formation, phagocytosis capacity and IL-6 as well as TNFalpha formation ex vivo. Non-specific effects and dependencies on the type of application and LPS dose are discussed.
Müller
G
G
Federal Institute for Health Protection of Consumers and Veterinary Medicine, Jena, Germany.
Steinbach
G
G
Berndt
A
A
Köhler
H
H
D000818:Animals; D001980:Bronchi; D004305:Dose-Response Relationship, Drug; D007107:Immune System / Q000187:drug effects*; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D015850:Interleukin-6 / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D012016:Reference Values; D013552:Swine / Q000276:immunology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects; D014886:Weaning
D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C433788:lipopolysaccharide, E. coli O26-B6