title: Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells.
abstract: To evaluate the potential role of NK1.1 (CD161c) cells in autoimmune uveoretinitis, we treated experimental autoimmune uveoretinitis (EAU)-susceptible mice with anti-CD161c antibodies (PK136) to deplete natural killer (NK) cells. Injection of anti-CD161c antibodies deleted NK cells from the peripheral blood of EAU-susceptible mice. The T cell proliferative response against the ocular autoantigen K2 was not suppressed in mice treated with anti-CD161c antibody when compared with T cells from control mice. Although mice treated with anti-CD161c developed EAU, the clinical severity on days 17 and 19 after induction of EAU was significantly mild in anti-CD161c-treated mice compared with control mice. In addition, the histopathological severity of EAU was significantly milder in mice treated with anti-CD161c antibodies than controls 21 days after induction of EAU. Our results indicate that the severity of EAU is augmented by NK1.1(+) NK cells.
authors.affiliation: Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kotake
authors.forename: Taiki
authors.initials: T
authors.lastname: Morohashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Onoé
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity; D005260:Female; D007694:Killer Cells, Natural / Q000502:physiology*; D037181:Lectins, C-Type / Q000276:immunology; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains; D055651:NK Cell Lectin-Like Receptor Subfamily B; D012173:Retinitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D000906:Antibodies; D000950:Antigens, Ly; D000954:Antigens, Surface; C527211:Klrb1c protein, mouse; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B