Efficacy of sodium borate in the prevention of fatty liver in dairy cows.
The effects of sodium borate (100 mg/kg body weight, p.o., 15 days) from a month before expected calving until a month after calving were evaluated in dairy cows susceptible to fatty liver. Cows received either sodium borate (n = 13) or no treatment (n = 10). All cows had mild fatty livers and increased plasma triglycerides and very low density lipoprotein (VLDL) concentrations at the beginning of the experiment. The control group of cows developed significant fatty liver after calving, and 2 of them had severe fatty liver associated with clinical and biochemical abnormalities. There were no clinicopathological signs related to sodium borate administration. Serum triglycerides and VLDL concentrations before calving decreased significantly at calving and after calving in controls, and they were within the normal range only after calving. There were significant alterations during the experiment in some hematological and chemical variables between groups, within period, but they were within the normal range. Unlike treated cows, serum triglycerides and VLDL concentrations correlated with liver fat content after calving in untreated cows. Our results document that sodium borate decreases the degree of fatty liver in dairy cows during early lactation.
Basoglu
Abdullah
A
Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey. abasoglu@selcuk.edu.tr
Sevinc
Mutlu
M
Birdane
Fatih M
FM
Boydak
Murat
M
D000818:Animals; D001881:Borates / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D015243:Cholesterol, VLDL / Q000097:blood; D005234:Fatty Liver / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D001881:Borates; D015243:Cholesterol, VLDL; D014280:Triglycerides; C010634:sodium borate