Multivariate analysis by Cox Proportional Hazards Model on prognoses of patients with bile duct carcinoma after resection.
OBJECTIVE
To evaluate the influence of various clinicopathologic factors on the survival of patients with bile duct carcinoma after curative resection.


METHODS
A retrospective analysis was performed on 86 cases of bile duct carcinoma treated from January 1981 to September 1995. Fifteen clinicopathologic factors that could possibly influence survival were selected. A multivariate analysis of these individuals was performed using the Cox Proportional Hazards Model.


RESULTS
The overall cumulative survival rate was 73% for 1 year, 32% for 3 years and 19% for 5 years. The results of univariate analysis showed that the major significant prognostic factors for influencing survival of these patients were type of histological lesion, lymph node metastasis, pancreatic invasion, duodenal invasion, perineural invasion, macroscopic vessel involvement, resected surgical margin and depth of cancer invasion (P < 0.05). Pancreatic invasion, perineural invasion and lymph node metastases were the three most important prognostic factors determined by multivariate analysis using the Cox Proportional Hazards Model.


CONCLUSIONS
Pancreatic invasion, perineural invasion and lymph node metastases are the most important prognostic factors for bile duct carcinoma after curative resection.
He
Ping
P
Hepatobiliary Research Laboratory, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China. heping9920@sohu.com
Shi
Jingsen
J
Chen
Wuke
W
Wang
Zuoren
Z
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate