Molecular and serological identification of the HLA-A*3404 allele.
In this report we describe a novel HLA-A*34 allele, A*3404, which was initially detected by an unusual serological pattern in two unrelated individuals. Sequencing revealed that the new allele was identical to A*3402 in exons 2 and 3, except for a single nucleotide difference at position 238, changing codon 56 from glycine to arginine. The codon change resulted in positive serological reactions with several sera recognizing A30 and/or A31, implicating an important role for this position in epitope recognition. The allele was identified twice on the haplotype A*3404, B*1402, Cw*0802, DRB1*14, DQB1*05.
Voorter
C E M
CE
Tissue Typing Laboratory, University Hospital, Maastricht, The Netherlands.
Hepkema
B G
BG
Lems
S P M
SP
van den Berg-Loonen
E M
EM
D000483:Alleles; D000595:Amino Acid Sequence; D005787:Gene Frequency; D015791:HLA-A3 Antigen / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D044465:White People / Q000235:genetics
D015791:HLA-A3 Antigen