title: Cancer mortality among European asphalt workers: an international epidemiological study. I. Results of the analysis based on job titles.
abstract: BACKGROUND
  Inhalation of bitumen fumes is potentially carcinogenic to humans.
  
  
  METHODS
  We conducted a study of 29,820 male workers exposed to bitumen in road paving, asphalt mixing and roofing, 32,245 ground and building construction workers unexposed to bitumen, and 17,757 workers not classifiable as bitumen workers, from Denmark, Finland, France, Germany, Israel, the Netherlands, Norway, and Sweden, with mortality follow-up during 1953-2000. We calculated standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) based on national mortality rates. Poisson regression analyses compared mortality of bitumen workers to that of building or ground construction workers.
  
  
  RESULTS
  The overall mortality was below expectation in the total cohort (SMR 0.92, 95% CI 0.90-0.94) and in each group of workers. The SMR of lung cancer was higher among bitumen workers (1.17, 95% CI 1.04-1.30) than among workers in ground and building construction (SMR 1.01, 95% CI 0.89-1.15). In the internal comparison, the relative risk (RR) of lung cancer mortality among bitumen workers was 1.09 (95% CI 0.89-1.34). The results of cancer of the head and neck were similar to those of lung cancer, based on a smaller number of deaths. There was no suggestion of an association between employment in bitumen jobs and other cancers.
  
  
  CONCLUSIONS
  European workers employed in road paving, asphalt mixing and other jobs entailing exposure to bitumen fume might have experienced a small increase in lung cancer mortality risk, compared to workers in ground and building construction. However, exposure assessment was limited and confounding from exposure to carcinogens in other industries, tobacco smoking, and other lifestyle factors cannot be ruled out.
authors.affiliation: Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, Lyon, France. boffetta@iarc.fr
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Igor
authors.initials: I
authors.lastname: Burstyn
authors.forename: Timo
authors.initials: T
authors.lastname: Partanen
authors.forename: Hans
authors.initials: H
authors.lastname: Kromhout
authors.forename: Ole
authors.initials: O
authors.lastname: Svane
authors.forename: Sverre
authors.initials: S
authors.lastname: Langård
authors.forename: Bengt
authors.initials: B
authors.lastname: Järvholm
authors.forename: Rainer
authors.initials: R
authors.lastname: Frentzel-Beyme
authors.forename: Timo
authors.initials: T
authors.lastname: Kauppinen
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücker
authors.forename: Judith
authors.initials: J
authors.lastname: Shaham
authors.forename: Dick
authors.initials: D
authors.lastname: Heederik
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ahrens
authors.forename: Ingvar A
authors.initials: IA
authors.lastname: Bergdahl
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cenée
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
authors.forename: Pirjo
authors.initials: P
authors.lastname: Heikkilä
authors.forename: Mariëtte
authors.initials: M
authors.lastname: Hooiveld
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Britt G
authors.initials: BG
authors.lastname: Randem
authors.forename: Walter
authors.initials: W
authors.lastname: Schill
mesh_terms: D000328:Adult; D002423:Cause of Death; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D005060:Europe / Q000453:epidemiology; D006801:Humans; D006838:Hydrocarbons; D019570:Inhalation Exposure / Q000706:statistics & numerical data*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality*; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D009790:Occupations / Q000706:statistics & numerical data
chemical_list: D006838:Hydrocarbons; C006647:asphalt