title: Ionol (BHT) produces superoxide anion.
abstract: In aqueous medium etiolated wheat seedlings release superoxide anion (O2*-). Interaction of a synthetic antioxidant, butylated hydroxytoluene (BHT, ionol), with oxygen in the aqueous medium is accompanied by O2*- formation. This suggests that under certain conditions BHT behaves as a prooxidant. A natural antioxidant, superoxide dismutase (SOD), and also a wound healing preparation, emulsified denatured placenta (EDP), do not exhibit the prooxidant properties. In contrast to BHT, they reduce O2*- production by the etiolated wheat seedling system.
authors.affiliation: Institute of Agricultural Biotechnology, Russian Academy of Agricultural Sciences, Moscow, 127550, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Smirnova
authors.forename: Yu I
authors.initials: YI
authors.lastname: Lyubimov
authors.forename: T G
authors.initials: TG
authors.lastname: Malinina
authors.forename: E Yu
authors.initials: EY
authors.lastname: Lyubimova
authors.forename: N I
authors.initials: NI
authors.lastname: Alexandrushkina
authors.forename: B F
authors.initials: BF
authors.lastname: Vanyushin
authors.forename: G M
authors.initials: GM
authors.lastname: Kolesova
authors.forename: L S
authors.initials: LS
authors.lastname: Yaguzhinsky
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D016877:Oxidants / Q000494:pharmacology*; D010100:Oxygen / Q000737:chemistry; D010920:Placenta / Q000737:chemistry; D012639:Seeds / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*; D014908:Triticum / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D016877:Oxidants; D014867:Water; D013481:Superoxides; D002084:Butylated Hydroxytoluene; D013482:Superoxide Dismutase; D010100:Oxygen