title: [Study on the relationship of balanced translocation t(1;12) with spermatogenesis].
abstract: OBJECTIVE
  To investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers.
  
  
  METHODS
  For twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis.
  
  
  RESULTS
  Chromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis.
  
  
  CONCLUSIONS
  Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis.
authors.affiliation: Department of Histology and Embryology, Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Zuo-Min
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Sha
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Zhou
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Li
mesh_terms: D000328:Adult; D001706:Biopsy; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D004200:Diseases in Twins / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*