NMDA receptor subunit expression following early postnatal exposure to ethanol.
Changes in NMDA receptor function following early postnatal exposure to ethanol may be related to the expression of NMDA receptor subunits. Following early postnatal exposure to ethanol, the expression of NMDA receptor subunits was examined. In cortex from ethanol-exposed rat pups at postnatal day 21, NR2A was significantly increased. There was no change in NR2B, thus suggesting that ethanol exposure during the third-trimester equivalent produces distinct effects on the NMDA receptor.
Nixon
Kimberly
K
Department of Psychology, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712, USA. knixon@med.unc.edu
Hughes
Peter D
PD
Amsel
Abram
A
Leslie
Steven W
SW
D020268:Alcohol-Induced Disorders, Nervous System / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism* / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol