title: [The role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cells apoptosis].
abstract: OBJECTIVE
  To study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis.
  
  
  METHODS
  Western blot analysis was used to investigate the expression of the mitogen-activated protein kinase.
  
  
  RESULTS
  When treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2) showed a dose-and time-dependent decreasing in phosphorylation status of these proteins through a western blot analysis, whereas protein levels of p38 MAPK remained unchanged.
  
  
  CONCLUSIONS
  The mitogen-activated protein kinase (MAPK) pathway may play an important ro1e in PYM-induced apoptosis of KB cells.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School of Stomatolog, Beijing 100081, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Dai
authors.forename: Zhenkang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Mingyong
authors.initials: M
authors.lastname: Zhou
authors.forename: Shifeng
authors.initials: S
authors.lastname: Yu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C021771:zhengguangmycin; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases