title: Assessment of trace aluminium content in parenteral solutions by combined cloud point preconcentration-flow injection inductively coupled plasma optical emission spectrometry.
abstract: A micelle-mediated phase separation without added chelating agents to preconcentrate trace levels of aluminium in parenteral solutions as a prior step to its determination by flow injection inductively coupled plasma optical emission spectrometry has been developed. The enrichment step is based on the cloud point extraction of aluminium with the non-ionic surfactant polyethyleneglycolmono-p-nonylphenylether (PONPE 7.5). The chemical variables affecting the sensitivity of the extractive-spectrometric procedure were studied in detail. After optimization, a preconcentration factor of 200 and a %E higher than 99.9 were achieved. The detection limit (DL) value of aluminium for the preconcentration of 50 ml of parenteral solution was 0.25 microgl(-1). The calibration graph using the preconcentration system for aluminium was linear with a correlation coefficient of 0.9997 at levels near the DLs up to at least 200 microgl(-1). The developed hyphenated assay, which thoroughly satisfies the typical requirements for pharmaceutical control processes, is appropriate to monitor the aluminium concentration in parenteral nutrition.
authors.affiliation: Area de Química Analítica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera (5700), San Luis, Argentina.
authors.forename: Lorena L
authors.initials: LL
authors.lastname: Sombra
authors.forename: Marta O
authors.initials: MO
authors.lastname: Luconi
authors.forename: Liliana P
authors.initials: LP
authors.lastname: Fernández
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Olsina
authors.forename: María F
authors.initials: MF
authors.lastname: Silva
authors.forename: Luis D
authors.initials: LD
authors.lastname: Martínez
mesh_terms: D000535:Aluminum / Q000032:analysis*; D017022:Flow Injection Analysis / Q000379:methods; D010288:Parenteral Nutrition; D019999:Pharmaceutical Solutions / Q000032:analysis*; D013052:Spectrometry, X-Ray Emission / Q000379:methods
chemical_list: D019999:Pharmaceutical Solutions; D000535:Aluminum