title: Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
abstract: Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
authors.affiliation: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 9F, 161, Sec. 6, Min-Chiuan East Road, Taipei 114, Taiwan, ROC. hphsieh@nhri.org.tw
authors.forename: Hsing-Pang
authors.initials: HP
authors.lastname: Hsieh
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Liou
authors.forename: Ying-Ting
authors.initials: YT
authors.lastname: Lin
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mahindroo
authors.forename: Jang-Yang
authors.initials: JY
authors.lastname: Chang
authors.forename: Yung-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Shuenn-Shing
authors.initials: SS
authors.lastname: Chern
authors.forename: Uan-Kang
authors.initials: UK
authors.lastname: Tan
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Chang
authors.forename: Tung-Wei
authors.initials: TW
authors.lastname: Chen
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Chang
authors.forename: Chiung-Chiu
authors.initials: CC
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001577:Benzophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry; D002453:Cell Cycle / Q000187:drug effects; D018360:Crystallography, X-Ray; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D013267:Stilbenes; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001577:Benzophenones; D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin