Preparation of epoxy-SiO2 hybrid sol-gel material for bone cement.
An organic-inorganic hybrid material, epoxy-SiO(2), was prepared by incorporating epoxy structure units covalently into a SiO(2) glass network via the sol-gel approach. The precursor was obtained by the reaction of diglycidyl ether of bisphenol A (DGEBA) with 3-aminopropyl trimethoxysilane (APTS). The precursor was then hydrolyzed and co-condensated with tetraethyl orthosilicate (TEOS) in tetrahydrofuran (THF) at room temperature to yield epoxy-SiO(2) hybrid sol-gel material having a 50 wt % SiO(2) content. Thermal properties of the hybrid material were characterized by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The hybrid sol-gel material epoxy-SiO(2) was the solid, powder component of bone cement. The liquid component contains bis-phenol-A glycidyl methacrylate (Bis-GMA), triethyleneglycol dimethacrylate (TEGDMA), and methyl methacrylate (MMA) with 25, 55, and 20 vol %, respectively. We discuss the comparison between the new epoxy-SiO(2) bone cement and the commercial Simplex P bone cement. Mechanical properties such as Young's modulus, compressive strength, hardness, and impact strength of the new epoxy-SiO(2) bone cement exceeded those of Simplex P bone cement. The tensile and bending strengths of the new epoxy-SiO(2) bone cement were approximately the same as those of Simplex P bone cement. In order to evaluate the biocompatibility of the new bone cement, an MTT test and optical microscopy were conducted in cell culture. Results indicated that the new epoxy-SiO(2) bone cement exhibits very low cytotoxicity compared with Simplex P bone cement.
Yang
Jen Ming
JM
Department of Chemical and Material Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan, Republic of China. jmyang@mail.cgu.edu.tw
Shih
Chun Hsiung
CH
Chang
Chen-Nen
CN
Lin
Feng Huei
FH
Jiang
Jian Ming
JM
Hsu
Ying Gev
YG
Su
Wen Yu
WY
See
Lai Chu
LC
D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002478:Cells, Cultured; D004852:Epoxy Compounds / Q000737:chemistry*; D005782:Gels; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry*
D001843:Bone Cements; D004852:Epoxy Compounds; D005782:Gels; D012822:Silicon Dioxide