Energetic depression caused by mitochondrial dysfunction.
Mitochondria not only provide most of the ATP needed for cell work and numerous specific anabolic and catabolic functions, they also contribute to Ca++ signalling and play a key role in the pathway to cell death. Impairment of mitochondrial functions caused by mutations of the mt-genome or by acute processes, is responsible for numerous diseases. Decreased concentrations of adenine nucleotides, leaky outer and inner mitochondrial membranes, and decreased activities of respiratory chain enzymes contribute to depression of cellular energy metabolism, one of the most important consequences of mitochondrial impairment as characterized by decreased cytosolic phosphorylation potentials.
Gellerich
Frank Norbert
FN
Muskellabor der Neurologischen Klinik, Martin-Luther-Universität Halle-Wittenberg, Germany. frank.gellerich@medizin.uni-halle.de
Trumbeckaite
Sonata
S
Chen
Ying
Y
Deschauer
Marcus
M
M ller
Tobias
T
Zierz
Stephan
S
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D020013:Calcium Signaling; D004579:Electron Transport; D004734:Energy Metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism
D000227:Adenine Nucleotides