title: Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.
abstract: Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). The genetic polymorphisms of these two enzymes might individually alter the production, release, reuptake or degradation of 5-HT during the treatment of selective serotonin reuptake inhibitors (SSRIs), leading to the individual differences in the antidepressant effects of SSRIs. The authors investigated whether a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and a TPH gene polymorphism in intron 7 (TPH-A218C) were associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder during a 6-week study with a specific dosage plan. Fifty-four patients completed the study. The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder.
authors.affiliation: Department of Psychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. cxw01076@nifty.com
authors.forename: Keizo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Shingo
authors.initials: S
authors.lastname: Naito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sato
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ito
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kamata
authors.forename: Hisashi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Itoh
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Inoue
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tezuka
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sugawara
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D005260:Female; D016666:Fluvoxamine / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics* / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000494:pharmacology*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; D016666:Fluvoxamine