New behavioral mutant rat exhibiting circling behavior (clx) controlled by a sex-linked recessive gene.
A male rat showing intermittent circling behavior was discovered among the Jcl:Wistar rats in our laboratories, and among its backcross offspring individuals showing the same behavior were found. The abnormalities in these animals were characterized by intermittent circling behavior (walking and/or running in circles) and head tossing with the neck twisted. No abnormalities were observed in fertility, delivery or pup mortality. The results of mating experiments indicated that the circling behavior phenotype is controlled by a single sex-linked recessive gene, and the mutant was named "circling behavior linked to X-chromosome (gene symbol: clx)." This circling behavior mutant is considered to be different from the previously reported mutants, the behavior in all of which has been found to be autosomally inherited. Sib-mating is continuing to produce an inbred strain with this newly discovered circling behavior mutant gene.
Fuji
Jun-Ichiro
J
Hikari Branch, Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Hikari, Yamaguchi 743-8502, Japan. Fuji_Junichirou@takeda.co.jp
Fukuda
Ryo
R
Imoto
Fumiyo
F
Ooshima
Yojiro
Y
D000818:Animals; D017849:Animals, Inbred Strains; D001522:Behavior, Animal / Q000502:physiology*; D003433:Crosses, Genetic; D005260:Female; D005808:Genes, Recessive; D040181:Genetic Diseases, X-Linked; D008297:Male; D009154:Mutation; D051381:Rats; D017208:Rats, Wistar