Calcium channel blocker, nimodipine, for the treatment of bipolar disorder during pregnancy.
Bipolar disorder in pregnancy was treated with nimodipine, because of lithium-induced nephrogenic diabetes insipidus. A 33-year-old primigravida woman at approximately 22 weeks 6 days of gestation had increasing blood pressure since 16 weeks of gestation, despite methyldopa 500 mg twice daily. She also had hypothyroidism and bipolar disorder, which were treated with levothyroxine and lithium carbonate, respectively. Nephrogenic diabetes insipidus developed, presumably because of chronic lithium exposure in high doses. She did not tolerate carbamazepine (the other agent commonly used for bipolar disorder in pregnancy). Thus, nimodipine was tried and tolerated well; furthermore, it was very effective in controlling her bipolar disorder. Nimodipine successfully controlled the bipolar disorder of a woman during pregnancy, who was intolerant of more commonly used agents.
Yingling
Dale R
DR
Department of Obstetrics and Gynecology, St. John Hospital and Medical Center, Detroit, Mich 48236, USA. Dale.Yingling@stjohn.org
Utter
Gregory
G
Vengalil
Shyla
S
Mason
Brian
B
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000150:complications; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy; D008094:Lithium / Q000009:adverse effects; D009553:Nimodipine / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology*; D013974:Thyroxine / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D009553:Nimodipine; D008094:Lithium; D013974:Thyroxine