title: Hypercalculia in savant syndrome: central executive failure?
abstract: BACKGROUND
  The existence of outstanding cognitive talent in mentally retarded subjects persists as a challenge to present knowledge. We report the case of a 16-year-old male patient with exceptional mental calculation abilities and moderate mental retardation.
  
  
  METHODS
  The patient was clinically evaluated. Data from standard magnetic resonance imaging (MRI) and two 99mTc-ethyl cysteine dimer (ECD)-single photon emission computer tomography (SPECT) (in resting condition and performing a mental calculation task) studies were analyzed.
  
  
  RESULTS
  Main neurologic findings were brachycephalia, right-side neurologic soft signs, obsessive personality profile, low color-word interference effect in Stroop test, and diffuse increased cerebral blood flow during calculation task in 99mTc-ECD SPECT. MRI showed anatomical temporal plane inverse asymmetry.
  
  
  CONCLUSIONS
  Evidence appears to support the hypothesis that savant skill is related to excessive and erroneous use of cognitive processing resources instigated by probable failure in central executive control mechanisms.
authors.affiliation: Unidad de Neurociencias, Hospital Civil de Guadalajara, Jalisco, Mexico. aagonza@prodigy.net.mx
authors.forename: Andrés Antonio
authors.initials: AA
authors.lastname: González-Garrido
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ruiz-Sandoval
authors.forename: Fabiola R
authors.initials: FR
authors.lastname: Gómez-Velázquez
authors.forename: José Luis Oropeza
authors.initials: JL
authors.lastname: de Alba
authors.forename: Teresa
authors.initials: T
authors.lastname: Villaseñor-Cabrera
mesh_terms: D000293:Adolescent; D003071:Cognition; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis*; D007360:Intelligence; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008568:Memory; D009483:Neuropsychological Tests; D009770:Obsessive Behavior; D013577:Syndrome; D013647:Task Performance and Analysis; D015899:Tomography, Emission-Computed, Single-Photon