title: [The effect of the synthetic analogue of gonadoliberin on immune response and factors of nonspecific resistance in rats and mice].
abstract: Gonadotropin-releasing hormone's synthetic analogue (surfagon) injected intraperitoneally exerted a dose-dependent influence on humoral immune response values in rats and on phagocytic and functional activity of neutrophiles in mice. Castration induced a reliable decrease of the immune response and character. It may be concluded that the surfagon effect is not mediated by steroids.
authors.affiliation: Kursk State Medical University, 305041, Kursk, 3 K. Marx St., Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Bobyntsev
authors.forename: L A
authors.initials: LA
authors.lastname: Sever'ianova
authors.forename: A I
authors.initials: AI
authors.lastname: Konoplia
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Smakhtin
authors.forename: A A
authors.initials: AA
authors.lastname: Kriukov
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000502:physiology*; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon