Effect of capsaicin on dynamics of neutrophil functional activity in Wistar rat venous blood.
Capsaicin in neurotoxic dose produced phasic changes in functional activity of sensory neuropeptides and venous blood neutrophils of Wistar rats. At the early terms after capsaicin injections, the sensitivity of neutrophils to bacterial stimuli decreased against the background of neuropeptide release from the sensory terminals. After 2 weeks, activity of neutrophils assessed by NBT-test increased against the background of depletion of neuropeptide stores, while total antioxidant activity of venous plasma decreased. On day 21 of capsaicin treatment, when the content of neuropeptides returned to the baseline level, functional activity of neutrophils decreased and plasma antioxidant activity returned to the control level.
Zhukova
E M
EM
Laboratory of Functional Neuromorphology, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. E.V.Zhukova@iph.ma.nsc.ru
Makarova
O P
OP
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D009479:Neuropeptides / Q000737:chemistry; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014680:Veins / Q000187:drug effects
D000975:Antioxidants; D009479:Neuropeptides; D002211:Capsaicin