title: Investigating the clinical utility of the percent of positive prostate biopsies in predicting PSA outcome following local therapy for patients with clinically localized prostate cancer.
abstract: The clinical utility of the percent of positive prostate biopsies in predicting prostate-specific antigen (PSA) outcome following radical prostatectomy (RP), or external beam radiation therapy (RT), for men with PSA detected, or clinically palpable prostate cancer was investigated. After accounting for the established prognostic significance of the PSA level, biopsy Gleason score and the clinical T-stage, the percent of positive prostate biopsies added clinically significant information regarding time to PSA failure following RP. These findings were validated in the intermediate risk patients using an independent surgical and radiation data set. Prostate Cancer and Prostatic Diseases (2000) 3, 259-264
authors.affiliation: Joint Center for Radiation Therapy, Harvard Medical School, Hospital of the University of Pennsylvania.
authors.forename: A V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: R
authors.initials: R
authors.lastname: Whittington
authors.forename: S B
authors.initials: SB
authors.lastname: Malkowicz
authors.forename: D
authors.initials: D
authors.lastname: Schultz
authors.forename: B
authors.initials: B
authors.lastname: Silver
authors.forename: L
authors.initials: L
authors.lastname: Henry
authors.forename: M
authors.initials: M
authors.lastname: Hurwitz
authors.forename: I
authors.initials: I
authors.lastname: Kaplan
authors.forename: C J
authors.initials: CJ
authors.lastname: Beard
authors.forename: J E
authors.initials: JE
authors.lastname: Tomaszewski
authors.forename: A A
authors.initials: AA
authors.lastname: Renshaw
authors.forename: A
authors.initials: A
authors.lastname: Wein
authors.forename: J P
authors.initials: JP
authors.lastname: Richie