Sub-second liquid chromatographic separations by means of shear-driven chromatography.
Utilizing the concept of shear-driven chromatography, we have been able to realize reversed-phase LC separations in flat rectangular nano-channels coated with a C8 monolayer and being as thin as 100 nm. At this scale, the separation kinetics are strongly enhanced, as is witnessed by the extremely short time (< 0.1 s) needed to separate a mixture of coumarin dyes. The observed plate numbers are still relatively small, because the experiments were conducted in ultra-short columns (< or = 1 mm) and under injection band width-limiting conditions.
Clic
D
D
Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. david.clicq@vub.ac.be
Vervoort
N
N
Vounckx
R
R
Ottevaere
H
H
Buijs
J
J
Gooijer
C
C
Ariese
F
F
Baron
G V
GV
Desmet
G
G
D002853:Chromatography, Liquid / Q000379:methods*