title: Liposomes possess drastic capabilities for topological transformation.
abstract: Morphological and topological changes of biological membranes play essential roles in cellular activities. It has been thought that these transformations are made possible through interactions with proteins. However, direct observation of giant liposomes by optical dark-field microscopy reveals that the lipid bilayer itself possesses the ability to undergo topological transformation.
authors.affiliation: Department of Molecular Biology, School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan. j46037a@nucc.cc.nagoya-u.ac.jp
authors.forename: Kingo
authors.initials: K
authors.lastname: Takiguchi
authors.forename: Fumimasa
authors.initials: F
authors.lastname: Nomura
authors.forename: Takehiko
authors.initials: T
authors.lastname: Inaba
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saitoh
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Hotani
mesh_terms: D000818:Animals; D048429:Cell Size / Q000187:drug effects; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism*; D008081:Liposomes / Q000737:chemistry; D008561:Membrane Fusion; D018715:Microscopy, Video; D008954:Models, Biological; D010539:Permeability; D011506:Proteins / Q000494:pharmacology
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D011506:Proteins