title: The ERGO genome analysis and discovery system.
abstract: The ERGO (http://ergo.integratedgenomics.com/ERGO/) genome analysis and discovery suite is an integration of biological data from genomics, biochemistry, high-throughput expression profiling, genetics and peer-reviewed journals to achieve a comprehensive analysis of genes and genomes. Far beyond any conventional systems that facilitate functional assignments, ERGO combines pattern-based analysis with comparative genomics by visualizing genes within the context of regulation, expression profiling, phylogenetic clusters, fusion events, networked cellular pathways and chromosomal neighborhoods of other functionally related genes. The result of this multifaceted approach is to provide an extensively curated database of the largest available integration of genomes, with a vast collection of reconstructed cellular pathways spanning all domains of life. Although access to ERGO is provided only under subscription, it is already widely used by the academic community. The current version of the system integrates 500 genomes from all domains of life in various levels of completion, 403 of which are available for subscription.
authors.affiliation: Integrated Genomics Inc., 2201 West Campbell Park Drive, Chicago, IL 60612, USA. ross@integratedgenomics.com
authors.forename: Ross
authors.initials: R
authors.lastname: Overbeek
authors.forename: Niels
authors.initials: N
authors.lastname: Larsen
authors.forename: Theresa
authors.initials: T
authors.lastname: Walunas
authors.forename: Mark
authors.initials: M
authors.lastname: D'Souza
authors.forename: Gordon
authors.initials: G
authors.lastname: Pusch
authors.forename: Eugene
authors.initials: E
authors.lastname: Selkov
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Liolios
authors.forename: Viktor
authors.initials: V
authors.lastname: Joukov
authors.forename: Denis
authors.initials: D
authors.lastname: Kaznadzey
authors.forename: Iain
authors.initials: I
authors.lastname: Anderson
authors.forename: Anamitra
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: Henry
authors.initials: H
authors.lastname: Burd
authors.forename: Warren
authors.initials: W
authors.lastname: Gardner
authors.forename: Paul
authors.initials: P
authors.lastname: Hanke
authors.forename: Vinayak
authors.initials: V
authors.lastname: Kapatral
authors.forename: Natalia
authors.initials: N
authors.lastname: Mikhailova
authors.forename: Olga
authors.initials: O
authors.lastname: Vasieva
authors.forename: Andrei
authors.initials: A
authors.lastname: Osterman
authors.forename: Veronika
authors.initials: V
authors.lastname: Vonstein
authors.forename: Michael
authors.initials: M
authors.lastname: Fonstein
authors.forename: Natalia
authors.initials: N
authors.lastname: Ivanova
authors.forename: Nikos
authors.initials: N
authors.lastname: Kyrpides
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D016678:Genome; D023281:Genomics; D008660:Metabolism; D011506:Proteins / Q000502:physiology
chemical_list: D011506:Proteins