title: [Effect of haidonghua powder(HDHP) on hypothalamic obesity in rats].
abstract: OBJECTIVE
  To study the effect of HDHP including Laminaria japonica Aresch. and Benincasa hispida(Thunb.) Cogn. etc. on antiobesity in rats with hypothalamic obesity.
  
  
  METHODS
  A rat model of hypothalamic obesity induced by MSG was used and the relative indexes was observed.
  
  
  RESULTS
  HDHP(2.5 g.kg-1) could significantly reduce the Lee's index as well as the size of fat cells. HDHP did not influence the serum levels of T3 and T4, insulin and aldosterone, did not inhibited appetite not led to diarrhea.
  
  
  CONCLUSIONS
  HDHP has the effect of anti-obesity, Without any influencing on the function of thyroid gland and metabolism of water and salt. The mechanism is related to the reduction of fat cell size and the accumulation of fat.
authors.affiliation: Department of Geriatrics, Xiyuan Hospital, China Academy of TCM, Beijng 100091, China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: W X
authors.initials: WX
authors.lastname: Wang
authors.forename: B H
authors.initials: BH
authors.lastname: Sun
authors.forename: D Z
authors.initials: DZ
authors.lastname: Zhao
authors.forename: P
authors.initials: P
authors.lastname: Gao
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D015992:Body Mass Index; D019662:Cucurbitaceae / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007027:Hypothalamic Diseases / Q000150:complications*; D007795:Laminaria / Q000737:chemistry; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019440:Anti-Obesity Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders