title: [The study of immune structure of Astrakhan region population to West Nile virus in 1998 and 1999].
abstract: Immunostructure of the Astrakhan Region population to West Nile fever (WNF) was studied in the preepidemic period (1998) and after the outbreak (1999). Among the sera obtained in 1998, 63 (26.3%) were positive in neutralization reaction, 84 (27.1%) in enzyme immunoassay IgG and 20 (7.8%) in HAIR. IgM-antibodies were found in none of 142 samples. Overall number of donors having antibodies to WNF virus by three reactions reached 97 (31.6%). In the sera obtained in 1999, virus neutralizing antibodies were detected in 72(44.4%) cases, specific IgM antibodies detected by EIA_in 5(3.1%), IgG_in 44(27.1%), antihemagglutinins_in 11 (6.9%). The number of positive findings in 4 reactions in 1999 was 81(50.0%). The results of examination of the sera collected for two years (1998 and 1999) were the following: of 402 samples examined in NR positive were 135(33.6%), of 304 five (1.6%) were IgM positive, 128(27.1%) of 472 were IgG positive, and 31(7.4%) of 417 responded in HAIR. Overall index of humoral immunity for 2 years was 37.9% (in males and females 39.8 and 32.8%, respectively. In persons aged 20-29 years_36.9%, 50-59 years_42.9%. Thus, by 2-year results, antibodies to WNF virus occurred in 51.9% rural citizens and 35.0% city population.
authors.forename: E O
authors.initials: EO
authors.lastname: Shishkina
authors.forename: A M
authors.initials: AM
authors.lastname: Butenko
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Gaĭdamovich
authors.forename: V F
authors.initials: VF
authors.lastname: Larichev
authors.forename: V I
authors.initials: VI
authors.lastname: Zhuravlev
authors.forename: S A
authors.initials: SA
authors.lastname: Shcherbakova
authors.forename: A I
authors.initials: AI
authors.lastname: Kovtunov
authors.forename: A F
authors.initials: AF
authors.lastname: Dzharkenov
authors.forename: V G
authors.initials: VG
authors.lastname: Sitkov
authors.forename: M G
authors.initials: MG
authors.lastname: Donskaia
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D001782:Blood Donors; D004196:Disease Outbreaks; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012424:Rural Population; D012426:Russia / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D014505:Urban Population; D014901:West Nile Fever / Q000097:blood / Q000453:epidemiology*; D014902:West Nile virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M