title: New variant of varicella-zoster virus.
abstract: In 1998, a varicella-zoster virus glycoprotein E (gE) mutant virus (VZV-MSP) was isolated from a child with chickenpox. VZV-MSP, representing a second VZV serotype, was considered a rarity. We isolated another VZV-MSP-like virus from an elderly man with herpes zoster. These gE mutant viruses may have arisen through independent mutation or may represent a distinct VZV subpopulation that emerged more than 50 years ago.
authors.affiliation: National Microbiology Laboratory, Winnipeg, Manitoba, Canada. graham_tipples@hc-sc.gc.ca
authors.forename: Graham A
authors.initials: GA
authors.lastname: Tipples
authors.forename: Gwen M
authors.initials: GM
authors.lastname: Stephens
authors.forename: Chris
authors.initials: C
authors.lastname: Sherlock
authors.forename: Margrit
authors.initials: M
authors.lastname: Bowler
authors.forename: Benny
authors.initials: B
authors.lastname: Hoy
authors.forename: Darrel
authors.initials: D
authors.lastname: Cook
authors.forename: Charles
authors.initials: C
authors.lastname: Grose
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D000077595:Famciclovir; D016679:Genome, Viral; D006562:Herpes Zoster / Q000188:drug therapy / Q000503:physiopathology*; D014645:Herpesvirus 3, Human / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012703:Serotyping
chemical_list: D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir