Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.
OBJECTIVE
To evaluate the association between leiomyomas and estrogen receptor gene polymorphism.


METHODS
Prospective study.


METHODS
Department of gynecology and genetics.


METHODS
Women with (n = 159) or without leiomyomas (n = 131).


METHODS
Polymerase chain reaction was used to detect dinucleotide (thymine-adenine [TA]) repeat polymorphisms upstream of the estrogen receptor gene. Genotypes were classified as A through P according to the number of the TA repeats from 12 to 27. Distributions of TA repeat for estrogen receptor in both groups were compared.


RESULTS
Genotypes A to E were detected in 10.7%, 18.9%, 15.7%, 16.4%, and 4.4%, respectively, of women with leiomyomas and 4.2%, 9.5%, 20.6%, 19.1%, and 10.3% of women without leiomyomas. Women with genotypes A and B (12 or 13 TA repeats) have a higher risk for leiomyomas, and those with genotype E (16 TA repeats) have a lower risk.


CONCLUSIONS
Estrogen receptor gene polymorphism probably contributes to the pathogenesis of leiomyoma and may predict the susceptibility to leiomyoma. The 12 and 13 TA repeats are associated with a higher risk of leiomyoma.
Hsieh
Yao-Yuan
YY
Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
Chang
Chi-Chen
CC
Tsai
Fuu-Jen
FJ
Tsai
Horng-Der
HD
Yeh
Lian-Shun
LS
Lin
Cheng-Chieh
CC
Tsai
Chang-Hai
CH
D000225:Adenine; D018900:Dinucleotide Repeats; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*; D013941:Thymine; D014594:Uterine Neoplasms / Q000235:genetics*
D011960:Receptors, Estrogen; D000225:Adenine; D013941:Thymine