title: Occupational asthma from fungicides fluazinam and chlorothalonil.
abstract: We report two cases of occupational asthma caused by sensitisation to powdered fungicides fluazinam and chlorothalonil, from the same fungicide formulation plant. Both developed work related lower respiratory symptoms after a latent interval of asymptomatic exposure. The diagnosis in each case was confirmed with a serial peak flow record in the workplace followed by specific inhalation tests. These fungicides are known to cause dermatitis; this report indicates that these compounds can induce specific immunological reactions in the airways as well as skin.
authors.affiliation: Department of Occupational & Environmental Medicine, Royal Brompton Hospital & NHLI, 1b Manresa Road, London SW3 6LR, UK. adrian@adraper.freeserve.co.uk
authors.forename: A
authors.initials: A
authors.lastname: Draper
authors.forename: P
authors.initials: P
authors.lastname: Cullinan
authors.forename: C
authors.initials: C
authors.lastname: Campbell
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Newman Taylor
mesh_terms: D000631:Aminopyridines / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D005541:Forced Expiratory Volume / Q000502:physiology; D005659:Fungicides, Industrial / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000631:Aminopyridines; D005659:Fungicides, Industrial; D009570:Nitriles; C075780:fluazinam; C005806:tetrachloroisophthalonitrile