Occupational asthma from fungicides fluazinam and chlorothalonil.
We report two cases of occupational asthma caused by sensitisation to powdered fungicides fluazinam and chlorothalonil, from the same fungicide formulation plant. Both developed work related lower respiratory symptoms after a latent interval of asymptomatic exposure. The diagnosis in each case was confirmed with a serial peak flow record in the workplace followed by specific inhalation tests. These fungicides are known to cause dermatitis; this report indicates that these compounds can induce specific immunological reactions in the airways as well as skin.
Draper
A
A
Department of Occupational & Environmental Medicine, Royal Brompton Hospital & NHLI, 1b Manresa Road, London SW3 6LR, UK. adrian@adraper.freeserve.co.uk
Cullinan
P
P
Campbell
C
C
Jones
M
M
Newman Taylor
A
A
D000631:Aminopyridines / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D005541:Forced Expiratory Volume / Q000502:physiology; D005659:Fungicides, Industrial / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*
D000631:Aminopyridines; D005659:Fungicides, Industrial; D009570:Nitriles; C075780:fluazinam; C005806:tetrachloroisophthalonitrile