title: The InterPro Database, 2003 brings increased coverage and new features.
abstract: InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).
authors.affiliation: EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. mulder@ebi.ac.uk
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Mulder
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Attwood
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Daniel
authors.initials: D
authors.lastname: Barrell
authors.forename: Alex
authors.initials: A
authors.lastname: Bateman
authors.forename: David
authors.initials: D
authors.lastname: Binns
authors.forename: Margaret
authors.initials: M
authors.lastname: Biswas
authors.forename: Paul
authors.initials: P
authors.lastname: Bradley
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.forename: Phillip
authors.initials: P
authors.lastname: Bucher
authors.forename: Richard R
authors.initials: RR
authors.lastname: Copley
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Courcelle
authors.forename: Ujjwal
authors.initials: U
authors.lastname: Das
authors.forename: Richard
authors.initials: R
authors.lastname: Durbin
authors.forename: Laurent
authors.initials: L
authors.lastname: Falquet
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fleischmann
authors.forename: Sam
authors.initials: S
authors.lastname: Griffiths-Jones
authors.forename: Daniel
authors.initials: D
authors.lastname: Haft
authors.forename: Nicola
authors.initials: N
authors.lastname: Harte
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hulo
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahn
authors.forename: Alexander
authors.initials: A
authors.lastname: Kanapin
authors.forename: Maria
authors.initials: M
authors.lastname: Krestyaninova
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.forename: David
authors.initials: D
authors.lastname: Lonsdale
authors.forename: Ville
authors.initials: V
authors.lastname: Silventoinen
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Orchard
authors.forename: Marco
authors.initials: M
authors.lastname: Pagni
authors.forename: David
authors.initials: D
authors.lastname: Peyruc
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Selengut
authors.forename: Florence
authors.initials: F
authors.lastname: Servant
authors.forename: Christian J A
authors.initials: CJ
authors.lastname: Sigrist
authors.forename: Robert
authors.initials: R
authors.lastname: Vaughan
authors.forename: Evgueni M
authors.initials: EM
authors.lastname: Zdobnov
mesh_terms: D000818:Animals; D003196:Computer Graphics; D030562:Databases, Protein; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D014584:User-Computer Interface
chemical_list: D011506:Proteins