title: [Lymphocyte reaction and humoral immune response to brain specific protein in children with pathology of the central nervous system].
abstract: Blood lymphocyte reaction to brain specific protein (BSP) in vitro and anti-brain antibodies (AB) levels were studied in newborns and infants with perinatal central nervous system (CNS) damages of various severity. A relationship between severity of CNS damages and a lymphocyte reaction to BSP as well as immuno-regulative index (IRI) changes. A combination of high AB to BSP levels with IRI elevation after cells incubation with BSP was found to be a favorable prognostic sign. In contrast, IRI reduction combined with higher AB levels appeared to be an unfavorable one.
authors.forename: A I
authors.initials: AI
authors.lastname: Autenshlius
authors.forename: O V
authors.initials: OV
authors.lastname: Ivanova
authors.forename: E P
authors.initials: EP
authors.lastname: Timofeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Kosacheva
authors.forename: E S
authors.initials: ES
authors.lastname: Mikhailova
mesh_terms: D000917:Antibody Formation; D001921:Brain / Q000276:immunology*; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D002493:Central Nervous System Diseases / Q000097:blood* / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011506:Proteins / Q000276:immunology* / Q000502:physiology
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D011506:Proteins