title: Genomic imprinting: could the chromatin structure be the driving force?
abstract: Genomic imprinting is traditionally defined as an epigenetic process leading to parental origin-dependent monoallelic expression of some genes. The current paradigm considers this unusual expression mode as the biological raison d être of imprinting. The present chapter proposes a critical review of our ideas about genomic imprinting in light of more recent investigatory progress. Many observations are difficult to explain on the basis of the current paradigm. Studies of allelic expression of many imprinted genes and other characteristics of chromatin domains containing clustered imprinted genes, such as replication and chromatin structure, revealed an unexpectedly complex situation that challenged the role of genomic imprinting as a mechanism of transcriptional regulation. The emerging picture is that parental imprinting is a feature of large chromatin domains with their own domain-wide characteristics. The primary biological function of imprinting may reside in the differential chromatin structure of the parental chromosomal regions and not in the monoallelic expression of some of the genes contained within them.
authors.affiliation: Institut Jacques Monod, CNRS, Ecole Pratique des Hautes Etudes, 75005 Paris, France.
authors.forename: Andras
authors.initials: A
authors.lastname: Paldi
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D018392:Genomic Imprinting; D006801:Humans
chemical_list: D002843:Chromatin