Biosynthesis of the lipophilic side chain in the cyclic hexadepsipeptide antibiotic IC101.
Antibiotic IC101 is a cyclic hexadepsipeptide having a C(15) lipophilic side chain. The side chain was shown to be synthesized in Streptomyces from acetate, propionate, and 3-methylbutyrate derived from leucine. Thus, the terminal isopentyl structure came from leucine and not from the mevalonate pathway.
Umezawa
Kazuo
K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan. umezawa@applc.keio.ac.jp
Ikeda
Yoko
Y
Naganawa
Hiroshi
H
Kondo
Shinichi
S
D000085:Acetates / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D005285:Fermentation; D045782:Hemiterpenes; D007930:Leucine / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000737:chemistry / Q000378:metabolism; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000085:Acetates; D000900:Anti-Bacterial Agents; D045782:Hemiterpenes; D010421:Pentanoic Acids; D010455:Peptides; D010456:Peptides, Cyclic; C085032:IC 101; C008216:isovaleric acid; D007930:Leucine