title: [Sensitivity of NMR spectroscopy].
abstract: Modern high-resolution liquid-phase NMR spectroscopy offers a huge array of techniques in the structure elucidation of small molecules, including their geometrical and dynamical aspects. This "repertoir" however can only be utilized properly if detection sensitivity is sufficiently high. The sensitivity issue has therefore become a crucial aspect of utilizing NMR spectroscopy amidst the ever increasing challenges the pharmaceutical R+D activities face. In the present paper we discuss the importance of high detection sensitivity in the process of structure elucidation. We also give a short overview of the most important development strategies aimed at increasing the sensitivity of NMR signal detection.
authors.affiliation: Richter Gedeon Rt., Kutatási Analitikai Fóosztály, Szerkezetkutatási Laboratórium, H-1475, Budapest 10, Pf. 27.
authors.forename: Casaba
authors.initials: C
authors.lastname: Szántay
authors.forename: Gábor
authors.initials: G
authors.lastname: Balogh
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations