[Inhaled corticoids and systemic secondary effects: controversies].
Studies that compare the systemic impact of inhaled corticosteroids (CI) abound in the literature often with contradictory results. Most of the studies report secondary biological effects in the suprarenal function without clinical effect due to taking high doses of inhaled corticosteroids. Surveillance of the secondary effects on bone is difficult to demonstrate. Finally, speed for recognition in asthmatic children during the first year of treatment is slowed down but the level at adult age is not affected. The variability of these results is associated with the former taking of corticosteroids by the general route. Administration of corticosteroids by the systemic route, therefore makes difficult the evaluation of secondary effects due only taking inhaled corticosteroids.
Köhler-Pâris
A
A
Service de Médecine Interne A-Pneumologie, CHU G. Doumergue, 5 rue Hoche, 30000 Nîmes.
Peyrière
H
H
Vincent
D
D
D000280:Administration, Inhalation; D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D000311:Adrenal Glands / Q000473:pathology; D000328:Adult; D000367:Age Factors; D001284:Atrophy; D001827:Body Height / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007223:Infant; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011446:Prospective Studies; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies
D000305:Adrenal Cortex Hormones; D011965:Receptors, Glucocorticoid