Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.
Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.
Mishima
Kenichi
K
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Tanaka
Takamitsu
T
Pu
Fengling
F
Egashira
Nobuaki
N
Iwasaki
Katsunori
K
Hidaka
Ryoji
R
Matsunaga
Kazuhisa
K
Takata
Jiro
J
Karube
Yoshiharu
Y
Fujiwara
Michihiro
M
D000818:Animals; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D024508:Tocotrienols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*; D024504:gamma-Tocopherol / Q000737:chemistry / Q000627:therapeutic use*
D024508:Tocotrienols; D014810:Vitamin E; D024504:gamma-Tocopherol; C082032:tocotrienol, alpha