Taxumairols X--Z, new taxoids from Taiwanese Taxus mairei.
In addition to 19-dydroxybaccatin III, 1beta-hydroxy-5 alpha-deacetylbaccatin I, taxayuntin G and 13-O-deacetyltaxumairol Z (4), three new taxane diterpenoids, taxumairols X (1), Y (2), Z (3) have been isolated from extracts of the Formosan Taxus mairei (LEMEE & LEVL.) S. Y. HU. Compounds 1-2 belong to the 11(15-->1)-abeo-taxane system, having a tetrahydrofuran ring at C-2, C-3, C-4 and C-20. The new compound 3 and 4, which was misidentified previously are derivatives of 11(15-->1)-abeo-taxane with an intact oxirane system. The structures of compounds 1-4 were elucidated on the basis of extensive two dimensional (2D)-NMR analysis.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, Taiwan, Republic of China. ychen@mail.nsysu.edu.tw
Chang
Yao-To
YT
Wang
Shih-Sheng
SS
Lin
Yu-Chi
YC
Chen
Ching-Yeu
CY
D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000302:isolation & purification*; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013624:Taiwan; D043823:Taxoids; D020946:Taxus / Q000737:chemistry*
D043823:Taxoids; C474049:taxumairol-X; C474050:taxumairol-Y; C474051:taxumairol-Z; D017239:Paclitaxel