Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves' disease.
Neuropsychiatric symptoms in the acute thyrotoxic phase of Graves' disease suggest involvement of brain processes. Short-echo-time proton MRS was used to measure the cerebral metabolite profile in newly diagnosed and untreated Graves' disease. Sixteen patients with Graves' disease and 18 age- and sex-matched healthy volunteers were studied. The patients had significantly reduced total choline and myo-inositol in the acute phase of Graves' thyrotoxicosis compared with the healthy volunteers.
Elberling
T V
TV
Memory Disorders Research Unit, Neuroscience Center, Copenhagen University Hospital, Rigshospitalet, Denmark.
Danielsen
E R
ER
Rasmussen
A K
AK
Feldt-Rasmussen
U
U
Waldemar
G
G
Thomsen
C
C
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D006111:Graves Disease / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000032:analysis / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009778:Occipital Lobe / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013971:Thyrotoxicosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*
D007294:Inositol; D013670:Sodium Pertechnetate Tc 99m; D002794:Choline