Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6.
Latency-associated transcripts of human herpesvirus 6 (H6LTs) (K. Kondo et al. J. Virol. 76:4145-4151, 2002) were maximally expressed at a fairly stable intermediate stage between latency and reactivation both in vivo and in vitro. H6LTs functioned as sources of immediate-early protein 1 at this stage, which up-regulated the viral reactivation.
Kondo
Kazuhiro
K
Department of Microbiology. Department of Pediatrics, Osaka University Medical School, Suita City, Osaka 565-0871, Japan. kkondo@micro.med.osakaa-u.a.jp
Sashihara
Junji
J
Shimada
Kazuya
K
Takemoto
Masaya
M
Amo
Kiyoko
K
Miyagawa
Hiromi
H
Yamanishi
Koichi
K
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018380:Hematopoietic Stem Cell Transplantation; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D007223:Infant; D016366:Open Reading Frames; D010750:Phosphoproteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D017735:Virus Latency
D017874:Immediate-Early Proteins; D010750:Phosphoproteins; D012333:RNA, Messenger; D012367:RNA, Viral; C458509:immediate-early 1 protein, human herpesvirus 6; D013755:Tetradecanoylphorbol Acetate