Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys.
The nonserotonergic benzodiazepine, triazolam, was compared with two 5-HT1A receptor agonists, 8-OH-DPAT and buspirone, in squirrel monkeys responding under a repeated-acquisition procedure. In each session, subjects acquired a 4-response sequence by responding sequentially on 3 keys in the presence of 4 discriminative stimuli (colors). Response sequences for each session were maintained by food presentation under a second-order fixed-ratio schedule. Errors produced a brief time-out but did not reset the sequence. In general, all of the drugs produced dose-dependent decreases in overall response rate and increases in the percentage of errors as the cumulative dose was increased. Together, these results indicate that 5-HT1A receptor agonists disrupt learning in squirrel monkeys by producing rate-decreasing and error-increasing effects in a manner comparable with the nonserotonergic benzodiazepine triazolam.
Winsauer
Peter J
PJ
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans 70112-1393, USA. pwinsa@lsuhsc.edu
Delatte
Marcus S
MS
Stevenson
Michael W
MW
Moerschbaecher
Joseph M
JM
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D012055:Reinforcement Schedule; D012453:Saimiri; D018490:Serotonin Agents / Q000494:pharmacology*; D014229:Triazolam / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D018490:Serotonin Agents; D014229:Triazolam; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D002065:Buspirone