Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III.
The maintenance of genome stability is important not only for cell viability, but also for the suppression of neoplastic transformation in higher eukaryotes. It has long been recognised that a common feature of cancer cells is genomic instability. Although the so-called three 'Rs' of genome maintenance, DNA replication, recombination and repair, have historically been studied in isolation, a wealth of recent evidence indicates that these processes are intimately interrelated and interdependent. In this article, we will focus on challenges to the maintenance of genome integrity that arise during the S-phase of the cell cycle, and the possible roles that RecQ helicases and topoisomerase III play in the maintenance of genome integrity during the process of DNA replication.
Oakley
Thomas J
TJ
Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
Hickson
Ian D
ID
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000818:Animals; D004265:DNA Helicases / Q000502:physiology*; D004260:DNA Repair; D004261:DNA Replication / Q000502:physiology; D004264:DNA Topoisomerases, Type I / Q000502:physiology*; D016678:Genome; D006801:Humans; D053484:RecQ Helicases; D016196:S Phase / Q000502:physiology*
D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; D004265:DNA Helicases; D053484:RecQ Helicases; D004264:DNA Topoisomerases, Type I