title: Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.
abstract: Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.
authors.affiliation: Pharmacyclics, Inc., 995 E. Arques Avenue, Sunnyvale, CA 94085, USA. dmagda@pcyc.com
authors.forename: Darren
authors.initials: D
authors.lastname: Magda
authors.forename: Nikolay
authors.initials: N
authors.lastname: Gerasimchuk
authors.forename: Philip
authors.initials: P
authors.lastname: Lecane
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
authors.forename: John E
authors.initials: JE
authors.lastname: Biaglow
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry / Q000378:metabolism*; D008665:Metalloporphyrins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D015394:Molecular Structure; D019815:Oxalic Acid / Q000737:chemistry / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D008665:Metalloporphyrins; D017319:Photosensitizing Agents; D011108:Polymers; D017382:Reactive Oxygen Species; C437683:motexafin gadolinium; D019815:Oxalic Acid; D001205:Ascorbic Acid