Effect of meso-2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men.
The efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) was evaluated in workers occupationally exposed to lead (Pb; blood level >50 microg/dL). Ten men were given 600 mg of DMSA per orem daily, for five days. Pb concentrations of whole blood and urine were determined throughout therapy. Hematology analyses, blood chemistry, and urinalysis were obtained at the start of the study, at the end of the DMSA treatment, and at 72 hours after the administration of the final dose. DMSA therapy had no influence on hepatic, hematologic, or renal functions and was effective in decreasing the concentration of blood Pb in all the subjects without adverse drug reactions.
Torres-Alanís
O
O
Centro Antivenenos, Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. otorres@ccr.dsi.uanl.mx
Garza-Ocañas
L
L
Piñeyro-López
A
A
D000284:Administration, Oral; D000328:Adult; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007854:Lead / Q000097:blood / Q000652:urine*; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D004113:Succimer / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D002614:Chelating Agents; D007854:Lead; D004113:Succimer