Synthesis of new, pyrene-containing, metal-chelating lipids and sensing of cupric ions.
The syntheses of several saturated, pyrene-containing, metal-chelating lipids are described. These lipids are capable of strongly binding to transition metal ions employing the metal-chelating headgroup. The excimer-to-monomer ratio of the pyrene groups changes with addition of cupric ions to the liposomes. Three other transition metal ions (Zn(2+), Ni(2+), and Hg(2+)) did not cause any appreciable changes in the excimer-to-monomer ratio. [reaction--see text]
Roy
Bidhan C
BC
Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA.
Chandra
Binita
B
Hromas
Daniel
D
Mallik
Sanku
S
D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry*; D008628:Mercury; D008670:Metals; D009532:Nickel; D011721:Pyrenes / Q000737:chemistry*; D015032:Zinc
D002614:Chelating Agents; D008055:Lipids; D008670:Metals; D011721:Pyrenes; D003300:Copper; D009532:Nickel; D008628:Mercury; D015032:Zinc