title: Human chorionic gonadotropin/luteinizing hormone receptor expression in the adult rat spinal cord.
abstract: The adult and fetal rat brain contains human chorionic gonadotropin/luteinizing hormone (hCG/LH) receptors, that are functional in mediating the neurotropic, neuroendocrine and behavioral actions of gonadotropins. We hypothesized that the spinal cord also contains these receptors. We have now demonstrated by in situ hybridization, immunohistochemistry, and topical autoradiography that the adult rat spinal cord expresses hCG/LH receptors. Positive cells included motoneurons, interneurons and/or glia in the intermediate and ventral gray matter, interneurons and/or glia in the dorsal gray matter, and oligodendrocytes or astrocytes in the white matter. The receptors were able to bind an appropriate ligand, (125)I-hCG. The functional significance of these receptors in the spinal cord is unknown, but we can speculate that they may be neurotrophic in function.
authors.affiliation: Department of Anatomical Sciences, University of Louisville School of Medicine, Louisville, KY 40292, USA.
authors.forename: Satish C
authors.initials: SC
authors.lastname: Rao
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Ch V
authors.initials: ChV
authors.lastname: Rao
authors.forename: David S K
authors.initials: DS
authors.lastname: Magnuson
mesh_terms: D000818:Animals; D001345:Autoradiography; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007395:Interneurons / Q000737:chemistry; D007457:Iodine Radioisotopes; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000737:chemistry; D009457:Neuroglia / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011974:Receptors, LH / Q000032:analysis* / Q000378:metabolism; D013116:Spinal Cord / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D007457:Iodine Radioisotopes; D011974:Receptors, LH; D007986:Luteinizing Hormone