title: Localizing value of torsional nystagmus in small midbrain lesions.
abstract: BACKGROUND
  The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal.
  
  
  METHODS
  The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evidence of vertical-torsional nystagmus on gaze straight ahead, focusing on the three-dimensional nystagmus components recorded with the three-dimensional search coil technique.
  
  
  RESULTS
  Combined lesions of the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) and the interstitial nucleus of Cajal (iC) are much more frequent than riMLF and, in particular, iC lesions alone. Eight patients showed contralesional torsional nystagmus with a conjugate vertical component on gaze straight ahead and had anatomic (MRI) and clinical evidence (slowing of vertical saccades) for riMLF involvement. Tonic ocular torsion and the subjective visual vertical were shifted to the contralesional side (n = 7). Torsional nystagmus to the ipsilesional side was uncommon (n = 3) and found in patients with midbrain lesions involving the iC, all of whom also had decreased time constants of the slow phases of gaze-evoked nystagmus.
  
  
  CONCLUSIONS
  Contrary to previous proposals, contralesional torsional nystagmus was the most frequent direction and is probably not compensatory for contralesional tonic ocular torsion. Small amplitude vertical saccades with normal velocities in association with ipsilesional torsional nystagmus may indicate isolated iC lesions. Torsional nystagmus following mesencephalic lesions may last for years and may help to distinguish rostral (riMLF) from caudal (iC) midbrain lesions.
authors.affiliation: Department of Neurology, University of Lübeck, Germany. helmchen_ch@neuro.mu-luebeck.de
authors.forename: C
authors.initials: C
authors.lastname: Helmchen
authors.forename: H
authors.initials: H
authors.lastname: Rambold
authors.forename: U
authors.initials: U
authors.lastname: Kempermann
authors.forename: J A
authors.initials: JA
authors.lastname: Büttner-Ennever
authors.forename: U
authors.initials: U
authors.lastname: Büttner
mesh_terms: D000328:Adult; D000368:Aged; D005133:Eye Movements / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D005654:Fundus Oculi; D019416:Head Movements / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology*; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology / Q000473:pathology*; D012438:Saccades / Q000502:physiology