title: Recent developments in avian influenza research: epidemiology and immunoprophylaxis.
abstract: Influenza A viruses have been isolated from humans, from several other mammalian species and a wide variety of avian species, among which, wild aquatic birds represent the natural hosts of influenza viruses. The majority of the possible combinations of the 15 haemagglutinin (HA) and nine neuraminidase (NA) subtypes recognized have been identified in isolates from domestic and wild birds. Infection of birds can cause a wide range of clinical signs, which may vary according to the host, the virus strain, the host's immune status, the presence of any secondary exacerbating microorganisms and environmental factors. Most infections are inapparent, especially in waterfowl and other wild birds. In contrast, infections caused by viruses of H5 and H7 subtypes can be responsible for devastating epidemics in poultry. Despite the warnings to the poultry industry about these viruses, in 1997 an avian H5N1 influenza virus was directly transmitted from birds to humans in Hong Kong and resulted in 18 confirmed infections, thus strengthening the pandemic threat posed by avian influenza (AI). Indeed, reassortant viruses, harbouring a combination of avian and human viral genomes, have been responsible for major pandemics of human influenza. These considerations warrant the need to continue and broaden efforts in the surveillance of AI. Control programmes have varied from no intervention, as in the case of the occurrence of low pathogenic (LP) AI (LPAI) viruses, to extreme, expensive total quarantine-slaughter programmes carried out to eradicate highly pathogenic (HP) AI (HPAI) viruses. The adoption of a vaccination policy, targeted either to control or to prevent infection in poultry, is generally banned or discouraged. Nevertheless, the need to boost eradication efforts in order to limit further spread of infection and avoid heavy economic losses, and advances in modern vaccine technologies, have prompted a re-evaluation of the potential use of vaccination in poultry as an additional tool in comprehensive disease control strategies. This review presents a synthesis of the most recent research on AI that has contributed to a better understanding of the ecology of the virus and to the development of safe and efficacious vaccines for poultry.
authors.affiliation: Istituto Superiore di Sanità, Laboratory of Veterinary Medicine, Vle Regina Elena 299, 00161 Rome, Italy. mtollis.iss.iy
authors.forename: M
authors.initials: M
authors.lastname: Tollis
authors.forename: L
authors.initials: L
authors.lastname: Di Trani
mesh_terms: D000818:Animals; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry / Q000276:immunology / Q000502:physiology; D005585:Influenza in Birds / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D011200:Poultry / Q000276:immunology / Q000821:virology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines