title: Synthesis and insecticidal activity of N-oxydihydropyrroles: 4-hydroxy-3-mesityl-5,5-dimethyl derivatives with various substituents at the 1-position.
abstract: A new series of N-oxydihydropyrrole derivatives was synthesized and evaluated for insecticidal activity against Nilaparvata lugens and Myzus persicae. Various substituents were introduced to the 1-position of the dihydropyrrole ring, and the derivatives obtained exhibited systemic and/or contact insecticidal activity. The structure-activity relationship revealed that small alkyoxy and alkoxyalkoxy groups were more favorable than alkylcarbonyloxy, alkoxycarbonyloxy, or sulfonyloxy groups as substituents at the 1-position.
authors.affiliation: Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd., 1041 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. mtitou@yasu.sankyo.co.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ito
authors.forename: Hideshi
authors.initials: H
authors.lastname: Okui
authors.forename: Harumi
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Mio
authors.forename: Ayako
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Obayashi
authors.forename: Takako
authors.initials: T
authors.lastname: Miura
authors.forename: Junko
authors.initials: J
authors.lastname: Nagai
authors.forename: Shinji
authors.initials: S
authors.lastname: Yokoi
authors.forename: Reiji
authors.initials: R
authors.lastname: Ichinose
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kodama
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyake
authors.forename: Miho
authors.initials: M
authors.lastname: Takashio
authors.forename: Jun
authors.initials: J
authors.lastname: Iwabuchi
mesh_terms: D000818:Animals; D001042:Aphids; D001937:Brassica / Q000187:drug effects; D018553:Cucumis sativus / Q000187:drug effects; D006430:Hemiptera; D007306:Insecticides / Q000138:chemical synthesis* / Q000633:toxicity; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012275:Oryza / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis* / Q000633:toxicity; D012639:Seeds; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D007659:Ketones; D011758:Pyrroles