title: The preparation of a fully differentiated "multiwarhead" siderophore precursor.
abstract: A protected, fully differentiated siderophore analogue has been prepared so that "Trojan Horse"-like siderophore drug conjugates with different drugs can be synthesized. The key steps in the synthesis include controlled preparation of an unsymmetrical urea and its conversion to a fully differentiated isocyanurate by reaction with chloro(carbonyl) isocyanate.
authors.affiliation: University of Notre Dame, Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, USA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Murray
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D017262:Siderophores / Q000138:chemical synthesis*; D014508:Urea / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D017262:Siderophores; D014508:Urea