CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease.
Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.
Howard
Laurence M
LM
Departments of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Neville
Katherine L
KL
Haynes
Lia M
LM
Dal Canto
Mauro C
MC
Miller
Stephen D
SD
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D023201:CD40 Ligand / Q000502:physiology*; D018188:Cardiovirus Infections / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006968:Hypersensitivity, Delayed / Q000209:etiology; D051379:Mice; D008969:Molecular Sequence Data; D013116:Spinal Cord / Q000473:pathology / Q000821:virology; D018417:Th1 Cells / Q000276:immunology; D017945:Theilovirus; D019562:Viral Load
D000906:Antibodies; D023201:CD40 Ligand