Rat nerve regeneration through a silicone chamber implanted with negative carbon ions.
We investigated whether a tube with its inner surface implanted with negatively-charged carbon ions (C(-) ions) would enable axons to extend over a distance greater than 10 mm. The tube was found to support nerves regenerating across a 15-mm-long inter-stump gap. Silicone treated with C(-) ions showed increased hydrophilic properties and cellular affinity, and axon regeneration was promoted with this increased biocompatibility.
Ikeguchi
Ryosuke
R
Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Kakinoki
Ryosuke
R
Matsumoto
Taiichi
T
Tsuji
Hiroshi
H
Ishikawa
Junzo
J
Nakamura
Takashi
T
D000818:Animals; D002244:Carbon; D007477:Ions; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012828:Silicones
D007477:Ions; D012828:Silicones; D002244:Carbon