title: Neurodegeneration: A non-apoptotic role for AIF in the brain.
abstract: A recent report provides new insights into the mechanisms of neurodegeneration. In a mouse mutant with progressive cerebellar and retinal degeneration, the expression of the apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of neurons that is associated with an imbalance in free radical metabolism and cell cycle re-entry.
authors.affiliation: Department of Pathology, Harvard Medical School, 200 Longwood Avenue, 02115, Boston, MA, USA. azad_bonni@hms.harvard.edu
authors.forename: Azad
authors.initials: A
authors.lastname: Bonni
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D051033:Apoptosis Inducing Factor; D001259:Ataxia / Q000235:genetics / Q000473:pathology; D001921:Brain / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D005420:Flavoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D009474:Neurons / Q000166:cytology / Q000473:pathology; D010088:Oxidoreductases / Q000378:metabolism
chemical_list: D051033:Apoptosis Inducing Factor; D005420:Flavoproteins; D008565:Membrane Proteins; C494830:AIFM1 protein, mouse; D010088:Oxidoreductases