title: Myb induced myeloid protein 1 (Mim-1) is an acetyltransferase.
abstract: We have screened protein extracts from chicken blood cells for acetyltransferases. An in gel acetyltransferase assay revealed that a 32 kDa protein, which is more prevalent in whole blood when compared with erythrocyte cells, possessed an auto-acetylation activity. This protein was purified by a series of chromatographic steps, sequenced by Edman degradation and subsequently identified as Myb induced myeloid protein (Mim-1). Mim-1 has similarities to the conserved acetyltransferase motifs found in the GNAT superfamily of proteins and also contains three minimal GK acetylation motifs. These data identify Mim-1 as an acetyltransferase.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Stuart C H
authors.initials: SC
authors.lastname: Allen
authors.forename: Tim R
authors.initials: TR
authors.lastname: Hebbes
mesh_terms: D000123:Acetyltransferases / Q000302:isolation & purification / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000097:blood; D017124:Conserved Sequence; D004912:Erythrocytes / Q000201:enzymology; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D017421:Sequence Analysis; D020539:Sequence Analysis, Protein
chemical_list: D000123:Acetyltransferases; C077509:mim-1 protein, Gallus gallus