[Clinical and structural parallels in changes of the myocardial conduction system in diphtheria patients].
OBJECTIVE
Comparison of the results of clinical device investigations of the heart with morphological autopsy evidence in diphtheria.


METHODS
Hearts of 309 patients with diphtheria aged 25 to 80 years and 60 hearts of patients who died of diphtheria were investigated using ECG, echo-CG, doppler echo-CG, Holter ECG monitoring, biochemical tests of blood. Structural study of cardiac conduction included examination of the sinus-atrial node, atrioventricular node and bundle regarding the adjacent myocardium.


RESULTS
Variants of structural-functional state of the myocardium and conduction system are explained by variability of the pathological processes which arose due to individual features of the conduction system structure and location, relationships with the myocardium. In acute diphtheria (day 1-10) dystrophic, necrobiotic and vascular disorders prevailed followed on days 11-30 by inflammation ending in myocardiosclerosis. Nodes and bundles of the conduction system are affected less frequently than the myocardium.


CONCLUSIONS
A correlation exists between structural state of the cardiac conduction system and variants of clinical affection of the heart in diphtheria.
Iushchuk
N D
ND
Parkhomenko
Iu G
IuG
Chukbar
A V
AV
Tishkevich
O A
OA
Filippov
P G
PG
Ordian
A M
AM
El'shinka
T M
TM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004165:Diphtheria / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged