A clinical, serological, and immunological study in a Japanese traveler with dengue fever.
We describe the results of clinical, serological, and immunological studies in a Japanese traveler with dengue fever (DF). DF was confirmed by isolation of dengue virus from the serum, a positive direct reverse-transcription polymerase chain reaction (RT-PCR) test, and a high titer of anti-IgM antibody to dengue virus. Interestingly, in this patient infected by dengue virus serotype 3, we found a low CD4/CD8 ratio and a decrease in CD4 lymphocytes, a variation of cross-reaction to dengue virus serotypes 1, 2, and 4, and high serum interferon-gamma levels just after a transient elevation of interleukin-12.
Masaki
Hironori
H
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Hasebe
Futoshi
F
Ahmed
Kamruddin
K
Fukuda
Tomoaki
T
Furumoto
Akitsugu
A
Watanabe
Kiwao
K
Oishi
Kazunori
K
Igarashi
Akira
A
Nagatake
Tsuyoshi
T
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016516:CD4-CD8 Ratio; D003715:Dengue / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014195:Travel
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D018664:Interleukin-12; D007371:Interferon-gamma