mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation.
In this study we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat. We show that noxious stimulation increases the number of Fos-positive neurons in the dorsal horn of the thoracic and lumbar spinal cord, and that pretreatment with MPEP significantly reduces the number of Fos-positive neurons in these areas. These data indicate that mGlu5 is involved in the transmission of visceral pain in the spinal cord.
Bianchi
Rossella
R
Department of Biomedical Sciences and Biotechnology, University of Brescia, Via Valsabbina 19, 25124, Brescia, Italy. bianchi@med.unibs.it
Rezzani
Rita
R
Borsani
Elisa
E
Rodella
Luigi
L
D019342:Acetic Acid; D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement / Q000187:drug effects; D010812:Physical Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D016760:Proto-Oncogene Proteins c-fos; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C121465:6-methyl-2-(phenylethynyl)pyridine; D019342:Acetic Acid