[Possible mechanisms of the reciprocal influence of infections caused by HIV and hepatitis C virus].
Literature data on the pathogenesis of mixed infection caused by human immunodeficiency viruses (HIV), type I, and hepatitis C virus (HCV), as well as on possible mechanisms of the reciprocal influence of these viruses necessary to understand their co-existence, are reviewed. The extrahepatic replication of HCV, its role in the infectious process and its possible contribution to the course of mono- and co-infection are considered in detail. Much attention is paid to the specific features of immune response in HIV-HCV infection and the immunomediated mechanisms of the reciprocal influence of the viruses. The problem of the hepatotoxicity of antiretrovirus preparations, actively discussed in literature, is considered from biological positions. The role of the phenomenon of immunity reconstitution in cases of the exacerbation of chronic HCV infection in the course of the treatment of HIV infection as well as of other factors, in particular, infections caused by other parenterally transmitted viruses, in the course of HIV-HCV co-infection is pointed out.
Bobkova
M R
MR
Federal Research and Methodological Center for Prophylaxis and Control of AIDS, Moscow, Russia.
D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015497:HIV-1; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000821:virology; D014779:Virus Replication
D019380:Anti-HIV Agents