[Use of ascorbic acid for raising clinical response to long-acting nitrates].
The data of clinic observation and ECG-monitoring show that ascorbic acid significantly increases antianginal vasodilatory effects of nitroglycerine thus preventing from development of ischemic miocardial reaction in response to complamin injection. Incubation under anaerobe conditions of ascorbic acid solution with NO-donors (sodium nitrate, nitroglycerine) or with the blood of ischemic patients who had been treated for a long time with long-acting nitrovasodilators, results in liberation in Varburg vasculium of gas bubbles identified as nitrogen oxide according to hemoglobin nitrosylation. Activation of endogen NO-donors with ascorbic acid and taking antilogs of antianginal effects of exogenous nitroglycerine makes it possible to substantially increase the efficiency of nitratotherapy and nitratoprophylaxis of angina pectoris.
Vodoevich
V P
VP
Vinogradova
T A
TA
Serafimovich
I A
IA
Stepuro
I I
II
Chaĭkovskaia
N A
NA
Vinogradov
V V
VV
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000627:therapeutic use*; D004357:Drug Synergism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009574:Nitro Compounds / Q000378:metabolism* / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000378:metabolism* / Q000627:therapeutic use*
D009574:Nitro Compounds; D014665:Vasodilator Agents; D001205:Ascorbic Acid