title: Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis.
abstract: The aim of the present study was to analyze the levels of osteocalcin, deoxypyridinoline (Dpd) and interleukin-1beta as markers of bone metabolism in peri-implant crevicular fluid (PICF) from peri-implantitis patients. PICF was sampled from a total of 34 endosseous titanium implants from 16 patients; nine females (mean age 52.8, range 40-62 years) and seven males (mean age 56.0, range 36-66 years). The implants had been in place for a period of 9-112 months (mean; 35.8 months) since the loading. These sites were categorized as six peri-implantitis, eight peri-implant mucositis and 20 healthy implant. PICF volume from peri-implantitis sites was significantly higher than mucositis and healthy implant sites (P < 0.01). Osteocalcin levels in PICF from mucositis sites were significantly higher than healthy implants (P < 0.05), whereas peri-implantitis sites were not significantly different from either mucositis or healthy implant sites. Dpd could not be detected in any of the samples examined. IL-1beta levels in PICF from peri-implantitis sites were significantly higher than levels from peri-implant mucositis (P < 0.05) and healthy implant sites (P < 0.01). In conclusion, osteocalcin in PICF may reflect increased local bone turnover around implants. Further, IL-1beta should be a useful marker for peri-implant inflammation.
authors.affiliation: Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services, Niigata, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Murata
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Tatsumi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kato
authors.forename: Satoru
authors.initials: S
authors.lastname: Suda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Nunokawa
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takeda
authors.forename: Hisao
authors.initials: H
authors.lastname: Araki
authors.forename: Kitetsu
authors.initials: K
authors.lastname: Shin
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyata
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yoshie
mesh_terms: D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000378:metabolism; D000596:Amino Acids / Q000032:analysis*; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000032:analysis*; D010518:Periodontitis / Q000378:metabolism*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013280:Stomatitis / Q000378:metabolism; D013997:Time Factors; D014025:Titanium
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D015921:Dental Implants; D018836:Inflammation Mediators; D007375:Interleukin-1; D015675:Osteocalcin; C036020:deoxypyridinoline; D014025:Titanium