[Th1 lymphocytes in patients with extrinsic asthma].
BACKGROUND
Bronchial asthma is a multifactorial disease affecting the functionality of the bronchial tree and immunological changes.


OBJECTIVE
To determine if lymphocytes Th-1 have a role in extrinsic asthma of Mexican patients.


METHODS
We included in the study 39 patients with extrinsic asthma, living in Mexico City, and 27 healthy subjects, without allergy antecedents, with nutritional and immunological characteristics similar. It was determined the following data: production of IL-2 (in 5 patients and 5 controls), its receptor (in all participants), IFN-g (in 8 patients and 5 controls), and TNF-a (in 8 patients and 5 controls).


RESULTS
Values of IL-2, its receptor and IFN-gamma were higher in patients than in controls, with significant differences. There were not important differences about TNF-alpha.


CONCLUSIONS
Even causes of action change between lymphocytes Th-1 and Th-2 are not known, it is confirmed the moving from Th-2 to Th-1 as an active phenomenon in asthma.
Aguilar Angeles
Daniel
D
Servicio de Alergia e Inmunología Clínica del Hospital Juárez de México, SS. primo65@prodigy.net.mx
Serrano
Ernestina
E
Estrada Parra
Sergio
S
Rojo Gutiérrez
María Isabel
MI
Bermejo Guevara
Mario Alberto
MA
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma