Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo.
In this study, we compared the apoptotic activities of clinical and environmental isolates of Vibrio vulnificus toward macrophages in vitro and in vivo. The clinical isolates induced apoptosis in macrophage-like cells in vitro and in macrophages in vivo. This suggests that macrophage apoptosis may be important for the clinical virulence of V. vulnificus.
Kashimoto
Takashige
T
Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, Towada Aomori 034-8628, Japan. kashimot@vmas.kitasato-u.ac.jp
Ueno
Shunji
S
Hanajima
Miyuki
M
Hayashi
Hisae
H
Akeda
Yukihiro
Y
Miyoshi
Shinichi
S
Hongo
Toshiharu
T
Honda
Takeshi
T
Susa
Nobuyuki
N
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D006801:Humans; D017737:Macrophages, Peritoneal / Q000382:microbiology*; D008297:Male; D051379:Mice; D017747:Seafood / Q000382:microbiology; D014735:Vibrio Infections / Q000382:microbiology*; D041261:Vibrio vulnificus / Q000472:pathogenicity*; D014774:Virulence