Hitchhikers guide to the vacuole-mechanisms of cargo sequestration in the Cvt and autophagic pathways.
In the yeast Saccharomyces cerevisiae, precursor aminopeptidase I and alpha-mannosidase are selectively targeted via the Cvt and the autophagic pathways to the vacuole. Two studies now uncover the molecular basis of the selective sequestration of these two enzymes.
Thumm
Michael
M
University of Stuttgart, Institute of Biochemistry, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
D000626:Aminopeptidases / Q000378:metabolism; D001343:Autophagy; D003593:Cytoplasm / Q000502:physiology; D005800:Genes, Fungal; D008247:Lysosomes / Q000502:physiology; D008361:Mannosidases / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological; D020675:Peroxisomes / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014617:Vacuoles / Q000502:physiology*; D043323:alpha-Mannosidase
D029701:Saccharomyces cerevisiae Proteins; D008361:Mannosidases; D043323:alpha-Mannosidase; D000626:Aminopeptidases