Biokinetics of transdermal 3-hydroxyphenazepam.
The kinetics of labeled 3-hydroxyphenazepam (active phenazepam metabolite) after its intravenous and transdermal administration was studied. Biphasic kinetic of drug distribution in the organism was revealed; pharmacokinetic parameters and biological availability (1.32  0.12 for the plasma and 1.21 0.10 for the brain) were determined on the basis of total radioactivity of the plasma and brain.
Golovenko
N Ya
NY
I. I. Metchnikov National University, Odessa.
Larionov
V B
VB
Kravchenko
I A
IA
Ovcharenko
N V
NV
Aleksandrova
A I
AI
D000279:Administration, Cutaneous; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000494:pharmacology; D019540:Area Under Curve; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D051379:Mice; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; C038294:3-hydroxyphenazepam