Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.
Dujneungkunakorn
Taweekiat
T
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Sungkanuparph
Somnuek
S
Vibhagool
Asda
A
Pairoj
Wantanit
W
Chantratita
Wasun
W
Srichunrusami
Chutatip
C
Laothamatas
Jiraporn
J
Pulkes
Teeratorn
T
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D019635:Neurosurgical Procedures; D016133:Polymerase Chain Reaction; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome
D000998:Antiviral Agents