Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.
Lima
Margarida
M
Service of Clinical Hematology, Hospital Geral de Santo António, Porto, Portugal. mmc.lima@clix.pt
Pinto
Luísa
L
Dos Anjos Teixeira
Maria
M
Canelhas
Aurea
A
Mota
Alexandra
A
Cabeda
José Manuel
JM
Silva
Cidália
C
Queirós
Maria Luís
ML
Fonseca
Sónia
S
Santos
Ana Helena
AH
Brochado
Paulo
P
Justiça
Benvindo
B
D000368:Aged; D000369:Aged, 80 and over; D018956:CD5 Antigens / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D017455:Receptors, IgE / Q000032:analysis; D014178:Translocation, Genetic
D018956:CD5 Antigens; D017455:Receptors, IgE