title: Changes in cerebral oxygenation in children undergoing surgical repair of ventricular septal defects.
abstract: There have been few published studies on changes in cerebral oxygenation during paediatric cardiac surgery as measured by conventional near-infrared spectroscopy. We studied changes in cerebral oxygenation in 16 children undergoing surgical repair of ventricular septal defects. Fifteen of the patients showed similar patterns of changes: brain tissue concentrations of oxyhaemoglobin decreased significantly during cardiopulmonary bypass, whereas there was no significant change in brain tissue concentrations of deoxyhaemoglobin. In the remaining patient, who suffered decreased blood flow to the lower body during surgery, the pattern of changes was different to that of the other subjects. This patient suffered postoperative respiratory and renal failure. This study suggests that conventional near-infrared spectroscopy may be useful for clinical monitoring during ventricular septal defect repair.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 0608638, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Niida
authors.forename: K
authors.initials: K
authors.lastname: Hisano
authors.forename: Y
authors.initials: Y
authors.lastname: Hua
authors.forename: O
authors.initials: O
authors.lastname: Kemmotsu
authors.forename: T
authors.initials: T
authors.lastname: Murashita
authors.forename: K
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000704:Analysis of Variance; D002560:Cerebrovascular Circulation; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D011446:Prospective Studies; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin