Hypotensive activity and toxicology of constituents from Bombax ceiba stem bark.
A novel constituent, shamimicin, 1"', 1"""'-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran along with lupeol, which possesses potent hypotensive activity, has been isolated from Bombax ceiba stem bark. BCBMM--one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.
Saleem
Rubeena
R
Dr. HMI Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi-74600, Pakistan. rs127pk@yahoo.com
Ahmad
Syed Iqbal
SI
Ahmed
Mohammad
M
Faizi
Zareen
Z
Zikr-ur-Rehman
Sadia
S
Ali
Muhammad
M
Faizi
Shaheen
S
D000818:Animals; D035163:Bombax / Q000633:toxicity*; D005260:Female; D007022:Hypotension / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D024301:Plant Bark / Q000633:toxicity*; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity; D018547:Plant Stems / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts