title: Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria.
abstract: Penetration of cerebrospinal fluid (CSF) by artesunate and DHA was assessed in six adults with cerebral or severe malaria. Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing.
authors.affiliation: Tropical Diseases Research Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam. tdavis@cyllene.uwa.edu.au
authors.forename: Timothy M E
authors.initials: TM
authors.lastname: Davis
authors.forename: Tran Quang
authors.initials: TQ
authors.lastname: Binh
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Ilett
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Batty
authors.forename: Hoang Lan
authors.initials: HL
authors.lastname: Phuöng
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Chiswell
authors.forename: Vu Duong Bich
authors.initials: VD
authors.lastname: Phuong
authors.forename: Cindy
authors.initials: C
authors.lastname: Agus
mesh_terms: D000293:Adolescent; D000328:Adult; D037621:Artemisinins / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000077332:Artesunate; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D016779:Malaria, Cerebral / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol