[Effect and mechanism of active fraction A guizhi decoction on dual-directional thermoregulation: effect on heat shock protein in hypothalamus of rats].
OBJECTIVE
To investigate the effect of active fraction A in Guizhi Decoction (Fr.A) on dual-directional thermoregulation and its mechanism of influencing heat shock protein (HSP) in hypothalamus.


METHODS
Using Western blot method to measure HSP of hypothalamus in febrile and hypothermal rats.


RESULTS
Regulating the body temperature in dual-direction, Fr.A could antagonize the decrease of HSP contents of hypothalamus in hypothermal rats induced by aminopyrine, and abate the HSP content in febrile rats induced by yeast.


CONCLUSIONS
Fr.A adjusts the body temperature through regulating the contents of HSP of hypothalamus in febrile and hypothermal rats.
Huo
H R
HR
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Tan
Y Q
YQ
Zhou
A X
AX
Li
X Q
XQ
Guo
S Y
SY
Sun
Y R
YR
Jiang
T L
TL
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006360:Heat-Shock Proteins