Tissue engineering strategies for in vivo neovascularisation.
Neovascularisation is a promising alternative therapeutic approach to re-establish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angioplasty or bypass surgery. Several strategies are presently under investigation to induce vascularisation by stimulating the body's natural processes of vasculogenesis, angiogenesis and arteriogenesis. These strategies involve transplantation of various cell types into the ischaemic site and the delivery of recombinant angiogenic agents through direct protein administration or gene transfer. We will examine the basic approaches for these neovacularisation strategies and their therapeutic potential as demonstrated in animal models and human trials to date.
Ennett
Alessandra B
AB
Department of Biomedical Engineering, University of Michigan, 1011 N. University, Ann Arbor, MI 48109, USA.
Mooney
David J
DJ
D000818:Animals; D017690:Cell Transplantation / Q000502:physiology; D015316:Genetic Therapy; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D023822:Tissue Engineering / Q000379:methods*; D014652:Vascular Diseases / Q000628:therapy*
D006133:Growth Substances