title: Immunomodulatory effect of glutoxim on some activities of isolated human neutrophils and in whole blood.
abstract: Activity of Glutoxim, a sulfur-containing hexapeptide with immunomodulating effect on lymphocytes, was studied on human neutrophils. Commercial available agent containing the substance, Glutoxim, was used. At the doses of 1, 3, 6 or 100 microg/mL the drug stimulated the superoxide anion and hypochlorous acid generation in resting neutrophils but inhibited them in cells stimulated with zymosan or PMA. The only inhibiting effect was observed on nitric oxide production in LPS-stimulated RAW 264.7 cells. The drug also influenced neutrophil chemotaxis showing chemoattractant activity on cells and inhibiting fMLP-induced chemotaxis. These effects on neutrophils confirm and extend range of Glutoxim immunomodulating abilities.
authors.affiliation: Department of Experimental Pathology and Microbiology, Medical School, University of Messina, 98125 Messina, Italy. vincenzo.fimiani@unime.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fimiani
authors.forename: Antonia
authors.initials: A
authors.lastname: Cavallaro
authors.forename: Tommaso
authors.initials: T
authors.lastname: Ainis
authors.forename: Galina
authors.initials: G
authors.lastname: Baranovskaia
authors.forename: Olga
authors.initials: O
authors.lastname: Ketlinskaya
authors.forename: Leonid
authors.initials: L
authors.lastname: Kozhemyakin
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006997:Hypochlorous Acid / Q000378:metabolism; D051379:Mice; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D009569:Nitric Oxide / Q000096:biosynthesis; D009842:Oligopeptides / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C462699:glutoxim; D013481:Superoxides; D009569:Nitric Oxide; D009240:N-Formylmethionine Leucyl-Phenylalanine; D006997:Hypochlorous Acid; D013755:Tetradecanoylphorbol Acetate