title: Enhancement of the relative uptake of 18F-FDG in mouse fibrosarcoma by rolipram.
abstract: The effect of rolipram, a selective phosphodiesterase type 4 inhibitor, on the uptake of 18F-fluorodeoxyglucose (18F-FDG) in tumor tissue was examined in mice transplanted with NFSa fibrosarcoma. The uptake indexes of 18F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatment with 3 mg/kg of rolipram (heart: 13%, skeletal muscle: 14%, brain: 31%), but fibrosarcoma tissue showed only a 50% reduction in the uptake index of 18F-FDG. The tumor/muscle ratio of radioactivity 30 min after 18F-FDG injection was consequently enhanced from 1.9 to 6.5 by rolipram. This indicates the possible use of rolipram to enhance the sensitivity of tumor detection, as well as characterization of tumors in 18F-FDG PET.
authors.affiliation: Department of Medical Physics, School of Allied Health Science Faculty of Medicine, Osaka University, Suita-shi, Japan. kkoba@sahs.med.osaka-u.ac.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Rie
authors.initials: R
authors.lastname: Hosoi
authors.forename: Sotaro
authors.initials: S
authors.lastname: Momosaki
authors.forename: Sachiko
authors.initials: S
authors.lastname: Koike
authors.forename: Koichi
authors.initials: K
authors.lastname: Ando
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Nishimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005354:Fibrosarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects; D006614:Hindlimb / Q000601:surgery; D007089:Image Enhancement / Q000379:methods; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D009206:Myocardium / Q000378:metabolism; D009368:Neoplasm Transplantation; D010949:Plasma / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D020889:Rolipram / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D020889:Rolipram