[Observation on the effect of GM-CSF and alpha-INF joint treatment on chronic hepatitis B].
OBJECTIVE
To observe the effect of GM-CSF and alpha-INF joint treatment on chronic hepatitis B.


METHODS
GM-CSF treatment combined with alpha-INF was set up as experimental group and alpha-INF alone as the control. At the same time, we counted the blood leukocytes, monocytes and granulocytes of the patients.


RESULTS
The short-term and long-term effective rates of the experimental group were 61% (11/18) and 67% (12/18) respectively, while those of the control group were 44% (8/18) and 33% (6/18) respectively. The leukocyte, monocyte and granulocyte counting in blood of patients treated with GM-CSF and alpha-INF increased significantly.


CONCLUSIONS
GM-CSF and alpha-INF joint treatment is effective for chronic hepatitis B. The mechanism may be related with the increasing number of monocytes in blood, hence to improve the antigen delivering ability.
Shao
C
C
Department of Infectious Diseases, Eighth Hospital of Xian, Xi'an 710061, China.
Liu
W
W
Chen
X
X
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D016898:Interferon-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor