title: [Dynamics of autoantibodies in elderly persons in the process of vaccination with Grippol and multicomponent vaccine VP-4].
abstract: The dynamics of antibodies to organ specific and organ nonspecific antigens in the process of combined immunization with Grippol, an influenza polymer subunit vaccine and polycomponent vaccine VP-4 used for prophylaxis of acute respiratory infections, was under study. Persons aged 65 years and older were vaccinated. Grippol alone was introduced in a single subcutaneous injection into 92 persons and Grippol in combination with vaccine VP-4--to 103 persons. B[symbol: see text]-4 Vaccine was introduced intranasally and orally (6-8 doses). The administration of vaccine VP-4 was started simultaneously with vaccination with Grippol. Prior to immunization and 1 and 5 months later autoantibodies to the following antigens were detected: DNA (native and denaturated), collagen, elastin, myelin basic protein, microsomal fractions of kidneys, lungs, heart, liver, intestine, pituitary body, thyroid gland, pancreas, adrenal glands, ovaries, mucous and muscular layers of stomach. The number of persons with the level of antibodies at least to one of the antigens under study exceeding the normal values prior to vaccination varied from 19.4 +/- 8.6% to 41.5 +/- 7.7%, the average values of positive sera being 0.26 +/- 0.05 to 0.32 +/- 0.08 delta OD. One and 5 months after vaccination both values varied within the same limits in both groups. Immunization with Grippol as well as with its combination with vaccine VP-4 was found to increased spectrum of antibodies to tissue antigens and their increased content. The data give evidence that Grippol and vaccine Vp-4, introduced according to the immunization schedule used in these experiments, do not induce development of autoimmune processes.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: N E
authors.initials: NE
authors.lastname: Iastrebova
authors.forename: A V
authors.initials: AV
authors.lastname: Poddubikov
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D003094:Collagen / Q000276:immunology; D004247:DNA / Q000276:immunology; D004549:Elastin / Q000276:immunology; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control; D007279:Injections, Subcutaneous; D008861:Microsomes / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D012141:Respiratory Tract Infections / Q000517:prevention & control; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001428:Bacterial Vaccines; C408342:Grippol; D007252:Influenza Vaccines; D004676:Myelin Basic Protein; C088865:VP-4 vaccine; D017778:Vaccines, Combined; D003094:Collagen; D004247:DNA; D004549:Elastin