title: Chronic metoclopramide therapy for diabetic gastroparesis.
abstract: OBJECTIVE
  To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.
  
  
  METHODS
  Medical literature was accessed through MEDLINE (1965 to October 2002) and PubMed (1965 to October 2002). Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced.
  
  
  RESULTS
  Metoclopramide is often used for diabetic gastroparesis, despite the risk of tardive dyskinesia. Published information is limited regarding long-term efficacy and toxicity of metoclopramide. The literature was assessed concerning these topics.
  
  
  CONCLUSIONS
  Limited data do not provide sufficient evidence to conclude whether metoclopramide is efficacious for chronic use. Routine monitoring may mitigate the risk associated with metoclopramide therapy.
authors.affiliation: Case Management Services, Bay Area Medical Center, Marinette, WI 54143-4242, USA. plata@bamc.org
authors.forename: Paul F
authors.initials: PF
authors.lastname: Lata
authors.forename: Denise L Walbrandt
authors.initials: DL
authors.lastname: Pigarelli
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D048909:Diabetes Complications; D004334:Drug Administration Schedule; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008787:Metoclopramide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000932:Antiemetics; D008787:Metoclopramide