title: [The efficacy of the native flumazenil for acute poisoning with benzodiazepines].
abstract: OBJECTIVE
  To evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines.
  
  
  METHODS
  One hundred and twenty-six patients with unconsciousness from benzodiazepines-induced self-poisoning were randomly divided into two groups: flumazenil group(Group II, 63 cases) were treated with flumazenil, and conventional-medicine group(Group I, 63 cases) with placebo(glucose, vitamin C, KCl). A modified Glasgow Coma Scale(MGCS) and Observer's Assessment of Alertness/Sedation Scale(OAA/S) were used in the assessment of consciousness.
  
  
  RESULTS
  MGCS were increased by 5.3, 8.0, 9.4 and 7.3 at 15 min, 30 min, 60 min and 180 min after intravenous flumazenil(P < 0.01) and by 5.2, 7.7, 8.7 and 6.9 in comparison with conventional-medicine group(P < 0.01). OAA/S increased by 1.9 compared with conventional-medicine group(P < 0.01). No severe side-effects were found in the treatment.
  
  
  CONCLUSIONS
  Flumazenil might improve benzodiazepines-induced unconsciousness markedly and may be the most effective antagonist of benzodiazepines.
authors.affiliation: Emergenyc Deartment, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: X H
authors.initials: XH
authors.lastname: Zhu
authors.forename: J X
authors.initials: JX
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D058787:GABA-A Receptor Antagonists; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D000931:Antidotes; D058787:GABA-A Receptor Antagonists; D005442:Flumazenil