title: Designing the selectivity of the fluorescent detection of amino acids: a chemosensing ensemble for histidine.
abstract: The imidazole group of histidine deprotonates and bridges the two CuII centers of a dimetallic polyamine macrocyclic complex, displacing the previously bound and quenched fluorescent indicator I. Thus, histidine recognition is signaled by the revival of the fluorescence of I. Selectivity with respect to other natural amino acids is achieved by choosing an indicator of tuned affinity toward the dicopper(II) receptor.
authors.affiliation: Università di Pavia, Dipartimento di Chimica Generale, via Taramelli 12, I-27100 Pavia, Italy.
authors.forename: Marta Ansa
authors.initials: MA
authors.lastname: Hortalá
authors.forename: Luigi
authors.initials: L
authors.lastname: Fabbrizzi
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marcotte
authors.forename: Floriana
authors.initials: F
authors.lastname: Stomeo
authors.forename: Angelo
authors.initials: A
authors.lastname: Taglietti
mesh_terms: D000596:Amino Acids / Q000032:analysis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006639:Histidine / Q000032:analysis* / Q000737:chemistry; D007700:Kinetics; D017186:Titrimetry / Q000379:methods
chemical_list: D000596:Amino Acids; D005456:Fluorescent Dyes; D006639:Histidine