Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong.
In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.
Kam
Kai Man
KM
Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China. kmkam@dh-gov.hk
Kam
Shirley Sin Yee
SS
Cheung
Danny Tze Leung
DT
Tung
Viola Wai Na
VW
Au
Wai Fun
WF
Cheung
May May
MM
D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006723:Hong Kong; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D015242:Ofloxacin / Q000494:pharmacology
D000890:Anti-Infective Agents; D015242:Ofloxacin