Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species.
Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.
Magda
Darren
D
Pharmacyclics, Inc., 995 E. Arques Avenue, Sunnyvale, CA 94085, USA. dmagda@pcyc.com
Gerasimchuk
Nikolay
N
Lecane
Philip
P
Miller
Richard A
RA
Biaglow
John E
JE
Sessler
Jonathan L
JL
D001205:Ascorbic Acid / Q000737:chemistry / Q000378:metabolism*; D008665:Metalloporphyrins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D015394:Molecular Structure; D019815:Oxalic Acid / Q000737:chemistry / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D008665:Metalloporphyrins; D017319:Photosensitizing Agents; D011108:Polymers; D017382:Reactive Oxygen Species; C437683:motexafin gadolinium; D019815:Oxalic Acid; D001205:Ascorbic Acid