title: An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes.
abstract: CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals.
authors.affiliation: Research Unit, Clinical Immunology and AIDS Center, Tel Aviv Sourasky Medical Center, 6 Weizmann Str., 64239, Tel Aviv, Israel. b.tartakovsky@medscape.com
authors.forename: Boris
authors.initials: B
authors.lastname: Tartakovsky
authors.forename: Mordechai
authors.initials: M
authors.lastname: Fried
authors.forename: Margalit
authors.initials: M
authors.lastname: Bleiberg
authors.forename: Dan
authors.initials: D
authors.lastname: Turner
authors.forename: Michael
authors.initials: M
authors.lastname: Hoffman
authors.forename: Israel
authors.initials: I
authors.lastname: Yust
mesh_terms: D000911:Antibodies, Monoclonal / Q000378:metabolism*; D000941:Antigens / Q000378:metabolism*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D018950:Lipopolysaccharide Receptors