[Successful treatment with G-CSF and corticosteroid of adult idiopathic autoimmune neutropenia presenting as recurrent enterocolitis].
A 63-year-old woman had previously been admitted to another hospital due to fever, abdominal pain and diarrhea. She was treated with fasting, antibiotics and G-CSF administration because of the coexistence of neutropenia, and the symptoms improved. However, discontinuation of G-CSF administration resulted in a recurrence of the neutropenia accompanied with enterocolitis. After admission to our hospital, a diagnosis for idiopathic AIN was performed as she tested positive in both granulocyte immunofluorescence and granulocyte agglutination tests. Administration of corticosteroid following G-CSF resulted in a continuous increase in the neutrophil count and the disappearance of anti-neutrophil autoantibodies.
Fujimi
Akihito
A
4th Department of Internal Medicine, Sapporo Medical University School of Medicine.
Matsunaga
Takuya
T
Ohnishi
Rika
R
Takemoto
Naofumi
N
Tanaka
Ikuta
I
Akiyama
Takehide
T
Sato
Tsutomu
T
Morii
Kazuhiro
K
Terui
Takeshi
T
Kogawa
Katsuhisa
K
Kato
Junji
J
Hirayama
Michiaki
M
Ohmi
Naohito
N
Sakamaki
Sumio
S
Niitsu
Yoshiro
Y
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D004760:Enterocolitis / Q000209:etiology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012008:Recurrence
D000893:Anti-Inflammatory Agents; D016179:Granulocyte Colony-Stimulating Factor; D011239:Prednisolone