Prominent myelin vacuolization in neurofibromatosis type 2.
Myelin vacuolization has previously been documented by MRI with histopathologic correlation in patients with neurofibromatosis type 1. This paper presents a patient with neurofibromatosis type 2 with MRI findings consistent with a prominent form of myelin vacuolization, unilaterally involving the right thalamus, globus pallidus and substantia nigra. On MRI, they appeared as multiple nodular-ovoid structures with a layered configuration. They were hypointense on T1-weighted, and FLAIR images, and hyperintense on T2-weighted images. On the apparent diffusion coefficient (ADC) map of an echo-planar diffusion imaging sequence, their ADC value ranged between 1.98 and 2.27x10(-3) mm(2)/s, a value higher than that of normal cerebral parenchyma, less than that of CSF.
Sener
R N
RN
Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey. rnsener@hotmail.com
Dzelzite
S
S
Migals
A
A
Raits
U
U
Veinbergs
A A
AA
D000328:Adult; D003711:Demyelinating Diseases / Q000473:pathology*; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009186:Myelin Sheath / Q000473:pathology*; D016518:Neurofibromatosis 2 / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index