The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia.
The aim of the study is to investigate the plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in normotensive and pre-eclamptic pregnancies. Peripheral venous blood samples were collected before labour (35.3 +/- 1.1 and 34.2 +/- 3.4 weeks for normotensive and pre-eclamptic, respectively) and placental tissues was obtained after delivery from 34 pre-eclampsia and 33 normotensive pregnancies. The mean plasma and placental levels of malondialdehyde were significantly higher, glutathione and superoxide dismutase levels were significantly lower in pre-eclamptic compared with normotensive patients (P < 0.01). The plasma and placental levels of malondialdehyde significantly increased, glutathione and superoxide dismutase significantly decreased with the increments in diastolic blood pressure. As a conclusion maternal circulating and placental tissue levels of lipid peroxides increase whereas antioxidants decrease in pre-eclampsia. The magnitude of oxidative stress and antioxidant changes correlate well with diastolic blood pressure.
Madazli
R
R
Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. madazli@ixir.com
Benian
A
A
Aydin
S
S
Uzun
H
H
Tolun
N
N
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione