Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors.
Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.
Labrosse
Béatrice
B
INSERM U-552, Recherche Antivirale, Hôpital Bichat-Claude Bernard, Paris, France.
Labernardière
Jean-Louis
JL
Dam
Elisabeth
E
Trouplin
Virginie
V
Skrabal
Katharina
K
Clavel
François
F
Mammano
Fabrizio
F
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002460:Cell Line; D015700:HIV Envelope Protein gp41 / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D008561:Membrane Fusion / Q000187:drug effects*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000187:drug effects; D019718:Receptors, CXCR4 / Q000187:drug effects; D017386:Sequence Homology, Amino Acid
D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D019713:Receptors, CCR5; D019718:Receptors, CXCR4