Predicted and experimental structures of integrins and beta-propellers.
Integrins and other cell surface receptors have been fertile grounds for structure prediction experiments. Recently determined structures show remarkable successes, especially with beta-propeller domain predictions, and also reveal how ligand binding by integrins is conformationally regulated.
Springer
Timothy A
TA
Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. springeroffice@cbr.med.harvard.edu
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016023:Integrins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conformation; D021122:Protein Subunits / Q000737:chemistry* / Q000378:metabolism; D016415:Sequence Alignment; D014841:von Willebrand Factor / Q000737:chemistry / Q000378:metabolism
D016023:Integrins; D008024:Ligands; D021122:Protein Subunits; D014841:von Willebrand Factor