Proteinuria in "normal" cadaver kidney donors.
BACKGROUND
More information is needed about cadaver organ donor pathophysiology.


METHODS
We quantitated preprocurement, timed urine protein excretion in 23 "normal" cadaver kidney donors, and correlated results with urine protein dipstick readings and multiple other parameters. We also attempted to measure microalbuminia in 10 subjects.


RESULTS
Seventeen of 23 cadaver donors did not have detectable proteinuria (albuminuria) by urine dipstick testing but had 1,704+/-2,900 mg (mean+/-SD) of quantitated daily urine protein, which did not correlate with creatinine clearance or urine volume. Donors with head trauma had numerically more quantitated proteinuria (3,000+/-5,160 vs. 970+/-670 mg/day, P=0.13). Microalbumin varied from 3 to 34% of the total urine protein concentration.


CONCLUSIONS
Significant proteinuria as measured by quantitative collection techniques is often present in excellent cadaver kidney donors and is not detected by dipstick testing. It may be a marker of important terminal pathophysiologic events and deserves further study.
Steiner
Robert
R
Lifesharing Community Organ and Tissue Donation, San Diego, CA, USA. rsteiner@ucsd.edu.
Chanchairujira
Thawee
T
Leyden
Sandra
S
D000419:Albuminuria / Q000175:diagnosis / Q000503:physiopathology; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D011507:Proteinuria / Q000175:diagnosis* / Q000503:physiopathology*; D011934:Reagent Strips; D012680:Sensitivity and Specificity; D014556:Urine
D011934:Reagent Strips; D003404:Creatinine