Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients.
Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls. We have found significantly higher representation of HLA-Cw*06 (odds ratio, 18.73; P(cor)<0.001) and significantly lower representation of HLA-Cw*07 (odds ratio, 0.41; P(cor)<0.038) in patients than in controls. Association of HLA-Cw*06 with psoriasis was even stronger in early age at onset (0-20 years) group: odds ratio, 77.71; P(cor)<0.001. Therefore, our population seems to belong to those with strong association of psoriasis with HLA-Cw*06.
Łuszczek
Wioleta
W
Department of Clinical Immunology, Laboratory of Immunogenetics, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, PL-53-114, Wroclaw, Poland.
Kubicka
Wioletta
W
Cislo
Maria
M
Nockowski
Piotr
P
Mańczak
Maria
M
Woszczek
Grzegorz
G
Baran
Eugeniusz
E
Kuśnierczyk
Piotr
P
D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology
D015236:HLA-C Antigens; C528994:HLA-C*06 antigen