title: The fluorapatite-anorthite system in biomedicine.
abstract: Glasses and glass ceramics of fluorapatite-anorthite (eutectic composition) were produced and characterized in order to evaluate their potential application in biomedicine. Bio-reactivity was determined by in vitro tests by immersion of powders in simulated plasma liquids as well as by in vivo experiments by implantation in rabbits. According to the results, the investigated materials are bio-acceptable since no toxic or other harmful evidence was detected. Glass-ceramics showed remarkable inertness, whereas glasses spontaneously dissolved in SBF and after 1 week moderate formation of apatite was observed, that however ceased within a month.
authors.affiliation: Department of Ceramics and Glass Engineering, University of Aveiro, 3810-193, Aveiro, Portugal. akis@cv.ua.pt
authors.forename: S
authors.initials: S
authors.lastname: Agathopoulos
authors.forename: D U
authors.initials: DU
authors.lastname: Tulyaganov
authors.forename: P A A P
authors.initials: PA
authors.lastname: Marques
authors.forename: M C
authors.initials: MC
authors.lastname: Ferro
authors.forename: M H V
authors.initials: MH
authors.lastname: Fernandes
authors.forename: R N
authors.initials: RN
authors.lastname: Correia
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001031:Apatites / Q000737:chemistry* / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D005898:Glass; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011817:Rabbits
chemical_list: D000538:Aluminum Silicates; D001031:Apatites; D001672:Biocompatible Materials; C074225:anorthite; C025105:fluorapatite