title: [Central nervous system damage in inflammatory demyelinating polyneuropathies].
abstract: The results of subclinical brain damage study of 20 patients with inflammatory demyelinating polyneuropathy, aged 46.5 +/- 3.7 years, are presented. Eleven patients were diagnosed to have Guillain--Barre syndrome and 9--chronic inflammatory demyelinating polyneuropathy. No clinical systems for central nervous system damage were found. Magnetic resonance tomography defected demyelination foci in periventricular and sub-cortical brain regions in 35% of the patients and diffuse atrophic process--in 55%. Registration of brainstem acoustic-evoked potentials showed bilateral latency increase and a change of a signal shape in 60% of the patients. Possible mechanisms of combined damage of central and peripheral nervous system in this pathology are discussed.
authors.forename: V V
authors.initials: VV
authors.lastname: Ponomarev
authors.forename: I P
authors.initials: IP
authors.lastname: Antonov
authors.forename: A I
authors.initials: AI
authors.lastname: Antonenko
authors.forename: G I
authors.initials: GI
authors.lastname: Ovsiankina
authors.forename: V I
authors.initials: VI
authors.lastname: Khodulev
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid / Q000209:etiology / Q000473:pathology; D006801:Humans; D007249:Inflammation; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000134:cerebrospinal fluid / Q000209:etiology / Q000473:pathology*; D011859:Radiography