One step closer to a sweet conclusion.
OtsA is required for the biosynthesis of trehalose, a nonreducing disaccharide that is important for bacterial survival and stress responses. In this issue of Chemistry & Biology, the structure of OtsA is uncovered and reveals an unexpected relationship between the enzyme's structure and function.
Withers
Stephen G
SG
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, Canada BC V6T 1Z1.
Wakarchuk
Warren W
WW
Strynadka
Natalie C J
NC
D001665:Binding Sites; D005964:Glucosyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D013379:Substrate Specificity
D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase