[Expression of autoantibodies to ICA512 and GAD in the sera of patients with diabetic ketoacidosis or ketonemia].
To explore the expression of the autoantibodies to ICA512 and GAD65 in the sera of diabetic patients who will be diagnosed as Type 1 diabetes, autoantibody assays were carried out in 15 diabetic patients complicated with ketonemia or ketoacidosis and in 19 healthy controls. The results were that the positive ratios of these autoantibodies were higher in the patient's sera than in the control's, and were higher in patients with shorter disease duration than those with longer disease duration. It is suggested that detecting these autoantibodies is helpful to the classification of diabetes and the disease duration affects the antibody's positive ratio.
Zhang
Y J
YJ
Department of Endocrinology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Chen
H L
HL
Yu
L P
LP
Han
X Y
XY
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D016883:Diabetic Ketoacidosis / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007527:Isoenzymes / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000276:immunology*; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8
D001323:Autoantibodies; D001324:Autoantigens; D007527:Isoenzymes; D008565:Membrane Proteins; C516862:PTPRN protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2