Pd-catalyzed allylic substitution using nucleophilic N-heterocyclic carbene as a ligand.
A nucleophilic N-heterocyclic carbene has been successfully used in a Pd(0)-catalyzed allylic substitution for the first time. It was found that allylic substitution with a soft nucleophile using a Pd-carbene catalyst proceeds via retention of configuration, the stereochemical reaction pathway being the same as that of the reaction using a Pd-phosphine complex. [reaction--see text]
Sato
Yoshihiro
Y
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Yoshino
Taro
T
Mori
Miwako
M