title: Purealidin S and purpuramine J, bromotyrosine alkaloids from the Fijian marine sponge Druinella sp.
abstract: Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.
authors.affiliation: Marine Natural Products Laboratory, Department of Chemistry, University of Aberdeen, AB24 3UE, Scotland, U.K.
authors.forename: Jioji N
authors.initials: JN
authors.lastname: Tabudravu
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
mesh_terms: D000470:Alkaloids; D000818:Animals; D000970:Antineoplastic Agents; D001969:Bromobenzenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005367:Fiji; D006801:Humans; D007938:Leukemia; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D011161:Porifera; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001969:Bromobenzenes; C473432:purealidin S; C473433:purpuramine J; D014443:Tyrosine