title: [Therapy refractory depression: symptom improvement after antidepressant and methylphenidate combination therapy].
abstract: In common, depressive disorders are treated with various antidepressants, the number of which is enormously increasing. Nevertheless, in some cases therapy resistance is observed. In these cases, neuroleptics are used as an alternative. Methylphenidate is effective for the treatment of ADHD and narkolepsia. But there are also studies, reporting an effect of methylphenidate in depressive disorders. We did not find any report about the efficiency of a combination of antidepressants and methylphenidate. We report a 32 year old "therapy resistant" depressive female. Monotherapy with antidepressants and methylphenidate was ineffective. Finally, a combination of antidepressants and methylphenidate was effective and lowered the HAMD-Score significantly. A combination of antidepressants and methylphenidate seems to be an effective new option for the treatment of "therapy resistant" depressions.
authors.affiliation: Abteilung für Kinder- und Jugendpsychiatrie, Universitätsklinik für Psychiatrie, Anichstrasse 35, A-6020 Innsbruck. helmut.niederhofer@uibk.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Niederhofer
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D008774:Methylphenidate