Accelerating water exchange for GdIII chelates by steric compression around the water binding site.
The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic GdIII complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA4- by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)]- is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.
Ruloff
Robert
R
Ecole Polytechnique Fédérale de Lausanne, ICMB, BCH, Lausanne, Switzerland.
Tóth
Eva
E
Scopelliti
Rosario
R
Tripier
Raphaël
R
Handel
Henri
H
Merbach
André E
AE