Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
Schomburg
Lutz
L
Institut für Experimentelle Endokrinologie, Universitätsklinikum Charité, Schumannstrasse 20/21, 10117 Berlin, Germany.
Schweizer
Ulrich
U
Holtmann
Bettina
B
Flohé
Leopold
L
Sendtner
Michael
M
Köhrle
Josef
J
D000818:Animals; D001692:Biological Transport / Q000235:genetics; D017353:Gene Deletion; D051379:Mice; D008822:Mice, Transgenic; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism*; D051149:Selenoprotein P; D051140:Selenoproteins
D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D012643:Selenium