[An experimental study combined on traditional Chinese medicine with immunosuppressant for treatment and prevention of tubular interstitial nephritis].
The objective of this study was to determine the effect of Chinese herbs and immune inhibitors on diffuse proliferative glomerulonephritis. The tubular-interstitial infiltration of cell, TGF-beta expression and interstitial fibrosis were investigated, and the relationship between clinical data and pathological changes was analysed. The results showed the infiltration of cells was inhibited in the "Chinese herbs combined with prednisone" group, the infiltration of cells, TGF-beta expression and interstitial fibrosis were all inhibited in the cyclophosphamide and prednisone" group. But in the prednisone group, interstitial fibrosis was not inhibited. These data suggest that the combined use of Chinese herbs, immunosuppressant and prednisone can inhibit the interstitial cell infiltration and prevent the interstitial fibrosis in diffuse proliferative glomerulonephritis.
Liu
X
X
Department of Nephrology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Tao
Y
Y
Zhang
X
X
Fan
J
J
Li
X
X
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005355:Fibrosis; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007684:Kidney Tubules / Q000473:pathology; D011241:Prednisone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000096:biosynthesis
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D016212:Transforming Growth Factor beta; D003520:Cyclophosphamide; D011241:Prednisone