title: Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice.
abstract: The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.
authors.affiliation: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità STA, Rome, Italy.
authors.forename: Lanfranco
authors.initials: L
authors.lastname: Fattorini
authors.forename: Dejiang
authors.initials: D
authors.lastname: Tan
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Iona
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mattei
authors.forename: Federico
authors.initials: F
authors.lastname: Giannoni
authors.forename: Lara
authors.initials: L
authors.lastname: Brunori
authors.forename: Simona
authors.initials: S
authors.lastname: Recchia
authors.forename: Graziella
authors.initials: G
authors.lastname: Orefici
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001372:Aza Compounds; D004359:Drug Therapy, Combination; D005000:Ethionamide / Q000008:administration & dosage / Q000627:therapeutic use*; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011804:Quinolines; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D005000:Ethionamide; D000077266:Moxifloxacin