[Preliminary studies on process and ultramicro-pulverization on pharmacodynamics of Leech].
OBJECTIVE
To compare pharmacodynamics of decoction and powder of Leech; To identify effect of pharmacodynamics of Leech with new methods of process and ultrmicro-pulverization.


METHODS
The size of ultramicor-powder of Leech and new method processed Leech is determined by BT-1500 size distributive instrument. It is compared that the pharmacodynamics of Leech decoction and powder as well as ultramicro-powder with new method processed of 1/2 decoction dose by anticoagulation and antithrombus action of mice. The safety of different samples is identified.


RESULTS
The pharmacodynamics of samples is as ultramicro-powder of Leech with new method processed > ultrmicro-powder of Leech > powder of Leech > decoction of Leech.


CONCLUSIONS
The ultramicro-powder of Leech with new method processed has better pharmacodynamic effect and the smell of Leech is improved.
Lu
W H
WH
Shandong University of Trditional Chinese Medicine, Jinan 250014, Shandong, China.
Qiu
F J
FJ
Wang
Z M
ZM
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology* / Q000633:toxicity; D001760:Bleeding Time; D006358:Hot Temperature; D007865:Leeches; D008297:Male; D008419:Materia Medica / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D010316:Particle Size; D011208:Powders; D011897:Random Allocation; D013678:Technology, Pharmaceutical / Q000379:methods
D000925:Anticoagulants; D008419:Materia Medica; D011208:Powders