Minimal tissue damage after stimulation of the motor thalamus in a case of chorea-acanthocytosis.
Autopsy findings are reported from a patient with chorea-acanthocytosis treated for 2 years by deep brain stimulation (DBS) of the motor thalamus. Postoperative testing showed a progressive improvement in axial truncal spasms. Although relatively high currents were used for 2 years in this patient, postmortem analysis showed minimal tissue damage in the vicinity of the electrode tip. It is concluded that DBS has little impact on the surrounding tissues.
Burbaud
P
P
Department of Clinical Neurophysiology, Hôpital Pellegrin, Bordeaux, France. Pierre.Burbaud@umr5543.u-bordeaux2.fr
Vital
A
A
Rougier
A
A
Bouillot
S
S
Guehl
D
D
Cuny
E
E
Ferrer
X
X
Lagueny
A
A
Bioulac
B
B
D000328:Adult; D001344:Autopsy; D002819:Chorea / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D004567:Electrodes, Implanted / Q000009:adverse effects; D006801:Humans; D008297:Male; D011859:Radiography; D013035:Spasm / Q000209:etiology / Q000628:therapy; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology*