Severe prolonged red blood cell aplasia and thrombocytopenia induced by parvovirus B19 infection in a patient with sarcoidosis.
We describe an acromegalic patient who developed a parvovirus B19 (PVB19) infection concomitantly with sarcoidosis, which was complicated by chronic red blood cell aplasia and severe thrombocytopenia, despite disappearance of the virus from serum and the production of high levels of specific polyclonal antibodies to PVB19. Mitogen stimulation of the patient's peripheral blood mononuclear cells induced oversecretion of interferon-gamma (IFN-gamma). Because hematopoietic suppression by IFN-gamma has been reported, a possible mechanism underlying reticulocytopenia and thrombocytopenia could involve IFN-gamma.
Viallard
Jean-François
JF
Service de Médecine Interne, Hôpital Haut-Lévêque, Centre François Magendie, 33604 Pessac Cedex, France. jean-francois.viallard@chu-bordeaux.fr
Parrens
Marie
M
Hermine
Olivier
O
Boiron
Jean-Michel
JM
Lafon
Marie-Edith
ME
Marit
Gérald
G
Reiffers
Josy
J
Pellegrin
Jean-Luc
JL
D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D010322:Parvoviridae Infections / Q000150:complications*; D017992:Parvovirus; D012010:Red-Cell Aplasia, Pure / Q000209:etiology*; D012507:Sarcoidosis / Q000150:complications* / Q000821:virology; D013921:Thrombocytopenia / Q000209:etiology*
D007371:Interferon-gamma