Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.
This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
Costa
Lucio G
LG
Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA. lgcosta@u.washington.edu
Cole
Toby B
TB
Jarvik
Gail P
GP
Furlong
Clement E
CE
D000818:Animals; D043303:Aryldialkylphosphatase; D016893:Carotid Stenosis / Q000235:genetics; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003324:Coronary Artery Disease / Q000235:genetics; D004950:Esterases / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D007306:Insecticides / Q000378:metabolism* / Q000633:toxicity; D015810:Linkage Disequilibrium; D009943:Organophosphorus Compounds; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D007306:Insecticides; D009943:Organophosphorus Compounds; D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human