title: The biokinetics of uranium migrating from embedded DU fragments.
abstract: Military uses of depleted uranium (DU) munitions have resulted in casualties with embedded DU fragments. Assessment of radiological or chemical health risks from these fragments requires a model relating urinary U to the rate of migration of U from the fragments, and its accumulation in systemic tissues. A detailed biokinetic model for U has been published by the International Commission on Radiological Protection (ICRP), but its applicability to U migrating from embedded DU fragments is uncertain. Recently, Pellmar and colleagues (1999) conducted a study at the Armed Forces Radiobiology Research Institute (AFRRI) on the redistribution and toxicology of U in rats with implanted DU pellets, simulating embedded fragments. This paper compares the biokinetic data from that study with the behavior of commonly studied forms of U in rats (e.g., intravenously injected U nitrate). The comparisons indicate that the biokinetics of U migrating from embedded DU is similar to that of commonly studied forms of U with regard to long-term accumulation in kidneys, bone, and liver. The results provide limited support for the application of the ICRP's model to persons with embedded DU fragments. Additional information is needed with regard to the short-term behavior of migrating U and its accumulation in lymph nodes, brain, testicles, and other infrequently studied U repositories.
authors.affiliation: Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. rwl@ornl.gov
authors.forename: R W
authors.initials: RW
authors.lastname: Leggett
authors.forename: T C
authors.initials: TC
authors.lastname: Pellmar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005389:Firearms; D005547:Foreign Bodies; D006801:Humans; D008962:Models, Theoretical; D051381:Rats; D014018:Tissue Distribution; D014501:Uranium / Q000493:pharmacokinetics*; D014947:Wounds and Injuries
chemical_list: D014501:Uranium