Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis.
An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp(2)-sp(3) fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products. [reaction--see text]
Clark
J Stephen
JS
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. j.s.clark@nottingham.ac.uk
Marlin
Frederic
F
Nay
Bastien
B
Wilson
Claire
C
D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D005658:Fungi / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D006540:Herbicides / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
D001685:Biological Factors; D005663:Furans; D006540:Herbicides; C071795:cornexistin; D010165:Palladium