title: In vitro anti-anaerobic activity of the cephalosporin derivative RWJ 54428, compared to seven other compounds.
abstract: Agar dilution MIC was used to test the activity of RWJ 54428, a new cephalosporin derivative, compared to imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin and metronidazole against 363 anaerobes isolated from clinical specimens. RWJ 54428 had low MICs against most beta-lactamase-negative Gram-negative rods, and all Gram-positive strains except Clostridium difficile. Imipenem and meropenem had the lowest MICs (MIC50s of 0.125 mg/L and MIC90s of 1.0 mg/L). Piperacillin-tazobactam, clindamycin and metronidazole were active against most strains, and ceftriaxone was active mainly against beta-lactamase-negative organisms.
authors.affiliation: Department of Pathology, Hershey Medical Center, PO Box 850, PA 17033, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Hoellman
authors.forename: L M
authors.initials: LM
authors.lastname: Kelly
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000254:growth & development; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D002511:Cephalosporins; C420727:RWJ 54428