title: Thrombolytics: prospects for new agents.
abstract: Thrombolytic therapy revolutionised the management of acute myocardial infarction (AMI). The ability to re-establish coronary artery patency with intravenous thrombolytic drugs has transformed our therapeutic approach, despite patency failures and re-occlusions. However, the established agents are not perfect and a number of novel thrombolytic drugs have consequently been developed and evaluated. This article reviews the currently available agents, discusses available adjunctive therapies and examines the future developments that may affect the application of this therapy.
authors.affiliation: Department of Cardiovascular Medicine, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK. dan.mckenzie@nottingham.ac.uk
authors.forename: Daniel B
authors.initials: DB
authors.lastname: McKenzie
authors.forename: Robert G
authors.initials: RG
authors.lastname: Wilcox
mesh_terms: D004358:Drug Therapy / Q000639:trends*; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy
chemical_list: D005343:Fibrinolytic Agents