Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients.
The delineation of dopamine dysfunction in the mentally ill has been a long-standing quest of biological psychiatry. The present study focuses on a recently recognized group of dopamine receptor-interacting proteins as possible novel sites of dysfunction in schizophrenic and bipolar patients. We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1. These levels of neuronal calcium sensor-1 were not influenced by age, gender, hemisphere, cause of death, postmortem period, alcohol consumption, or antipsychotic and mood stabilizing medications. The present study supports the hypothesis that schizophrenia and bipolar disorder may be associated with abnormalities in dopamine receptor-interacting proteins.
Koh
Phil Ok
PO
Departments of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA.
Undie
Ashiwel S
AS
Kabbani
Nadine
N
Levenson
Robert
R
Goldman-Rakic
Patricia S
PS
Lidow
Michael S
MS
D000428:Alcohol Drinking; D000818:Animals; D001344:Autopsy; D001714:Bipolar Disorder / Q000235:genetics* / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002423:Cause of Death; D005260:Female; D005786:Gene Expression Regulation; D000882:Haplorhini; D006801:Humans; D008297:Male; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides / Q000235:genetics*; D017397:Prefrontal Cortex / Q000378:metabolism*; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
D002135:Calcium-Binding Proteins; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides; C101464:frequenin calcium sensor proteins