title: An azoospermic male with an unbalanced autosomal-Y translocation.
abstract: An azoospermic male with an unbalanced translocation between the Y chromosome and chromosome 15 was examined in the present study. Testicular biopsy found only Sertoli cells only within the seminiferous tubules of the 35-year-old patient. Chromosome analysis, using the techniques of G and C banding and fluorescent in situ hybridization revealed an abnormal karyotype of 46,XY,der(15)t(Y;15)(q12;p11). Deoxyribonucleic acid (DNA) analysis confirmed the presence of the genes such as DAZ and YRRM1 which are known to control spermatogenesis. The cause of spermatogenetic dysfunction in this particular patient therefore.
authors.affiliation: First Department of Urology, Toho University School of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo 143, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahori
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroki
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Shirai
mesh_terms: D000328:Adult; D001706:Biopsy; D002871:Chromosome Banding; D002884:Chromosomes, Human, Pair 15; D041322:Chromosomes, Human, Y; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D013737:Testis / Q000166:cytology; D014178:Translocation, Genetic