title: Effect of intravenous propranolol on left ventricular apical ballooning without coronary artery stenosis (ampulla cardiomyopathy): three cases.
abstract: The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called 'takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did not have any intraventricular pressure gradients showed no improvement in the electrocardiographic and left ventricular wall motion abnormalities, the other 2 patients, who had significant intraventricular pressure gradients, did show improvement. Dynamic intraventricular obstruction might play a role in maintaining apical ballooning, at least, in patients exhibiting an intraventricular pressure gradient.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan. kyuma@sapmed.ac.jp
authors.forename: Michifumi
authors.initials: M
authors.lastname: Kyuma
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Tsuchihashi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shinshi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hase
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ooiwa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Abiru
authors.forename: Nobuichi
authors.initials: N
authors.lastname: Hikita
authors.forename: Tateo
authors.initials: T
authors.lastname: Adachi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shoji
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Fujise
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimamoto
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001794:Blood Pressure; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage*; D011859:Radiography; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol