[Effect of cytokines on repair of tendon injury].
OBJECTIVE
The review the effect of cytokines on repair of tendon injury and the relevant mechanism.


METHODS
By broadly consulting recent issues about cytokines involved in tendon repair, a variety of cytokines with effects in repairing injured tendon was made and the possible mechanisms were summarized, with unsolved problems discussed.


RESULTS
There were many cytokines participated in the procedure of tendon repair, among which insulin-like growth factor (IGF-1), transforming growth-beta 1 (TGF-beta 1) played significant roles. Most of the relevant researches were limited in experimental study in vitro.


CONCLUSIONS
Cytokines possibly can accelerate tendon repair and show great potentials in future clinical application.
Liang
L
L
Department of Pathology, 1st Military Medical University, Guangzhou Guangdong, P. R. China, 510515.
Ding
Y Q
YQ
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D013708:Tendon Injuries / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D053773:Transforming Growth Factor beta1; D014945:Wound Healing
D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2; D007334:Insulin-Like Growth Factor I