title: A comparative study of combined treatment with a collagen membrane and enamel matrix proteins for the regeneration of intraosseous defects.
abstract: Recent clinical study shows that periodontal regeneration therapy using enamel matrix proteins (Emdogain; EMD) is expected to have the same therapeutic effect as guided tissue regeneration (GTR). However, reports on the combined effect of both therapies are limited, and the clinical significance is not definite. In this study, clinical effects were studied by comparing a combination of EMD and GTR using a collagen membrane for intrabony defects with GTR monotherapy and EMD monotherapy. Sixty-one patients with 69 intrabony defects were included. Efficacy of treatment was evaluated at 6 months and 1 year by assessment of reduction of probing depth, probing attachment gain, and radiographic bone gain. There were no statistically significant differences between presurgical soft tissue measurements and defect characteristics for the three treatment groups. The results showed no significant differences in reduction of probing depth, probing attachment gain, or radiographic bone gain between the three treatment groups at both evaluation times. The combination of GTR using a resorbable membrane for intrabony defects and EMD did not enhance the therapeutic effect compared with each monotherapy.
authors.affiliation: Bunkyo Dori Dental Clinic, 2-4-4 Anagawa, lnage-Ku, Chiba City, Japan 263-0024. minabe-m@wk9.so-net.ne.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Minabe
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kodama
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Kogou
authors.forename: Kayo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Fushimi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Eiko
authors.initials: E
authors.lastname: Mitarai
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000704:Analysis of Variance; D001861:Bone Regeneration / Q000187:drug effects*; D016009:Chi-Square Distribution; D003094:Collagen; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D010512:Periodontal Index; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins; D003094:Collagen