Prominent expression of lysyl oxidase during mouse embryonic cardiovascular development.
By mRNA differential display in mouse hearts, lysyl oxidase (Lox), a key enzyme catalyzing cross-links in elastin and collagens, was found to be up-regulated between embryonic days 11 (E11) and 13 (E13). This was confirmed by semiquantitative RT-PCR. We analyzed its spatio-temporal expression pattern by in situ hybridization in regard to the development of myocardial cells, endocardial cushion tissue, aortic arch vessels, and epicardium.
Tsuda
Takeshi
T
Department of Dermatology and Cutaneous Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Pan
Te-Cheng
TC
Evangelisti
Lucia
L
Chu
Mon-Li
ML
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology* / Q000254:growth & development; D051379:Mice; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*; D015854:Up-Regulation
D008249:Protein-Lysine 6-Oxidase