title: Diagnosis of osteomyelitis in the diabetic foot with a 99mTc-HMPAO leucocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy.
abstract: BACKGROUND
  The aim of this prospective study was to assess the role of 99mTc-HMPAO leucocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy in the diagnosis of the diabetic foot infection (HMPAO-Leu/MDP).
  
  
  METHODS
  75 diabetic patients with suspected osteomyelitis were included. The HMPAO-Leu/MDP scan was considered to be consistent with osteomyelitis when the HMPAO-Leu uptake was concordant in all the incidences with an MDP bone uptake. A HMPAO-Leu uptake without concordant bone MDP activity was considered as a soft-tissue infection. The results of the HMPAO-Leu/MDP scan were compared to the following diagnostic criteria: bone infection was confirmed by radiological follow-up or bone biopsy; the absence of bone infection was confirmed by clinical (healing of the ulcer without antibiotherapy) and radiological follow up.
  
  
  RESULTS
  According to these criteria, among the 83 ulcers, bone infection was observed in 41 (49.4%): the HMPAO-Leu/MDP scan was positive in 38 cases, including 14 ulcers with normal or doubtful radiographs at inclusion. In the group of 42 ulcers without proven bone infection, the HMPAO-Leu/MDP scan was negative in 41 cases, including 17 lesions with a soft-tissue infection.
  
  
  CONCLUSIONS
  With a sensitivity of 92.6%, a specificity of 97.6%, the HMPAO-Leu/MDP scan is a reliable tool for the diagnosis of osteomyelitis in the diabetic foot. Neuroarthropathy did not affect the performances of the HMPAO-Leu/MDP scan. Owing to a high spatial resolution this test is very helpful to differentiate bone infection from soft-tissue infection especially in case of neuroarthropathy.
authors.affiliation: Service d'Endocrinologie-Diabétologie, CHU Rennes, France. Jean-Yves.Poirier@chu-rennes.fr
authors.forename: J Y
authors.initials: JY
authors.lastname: Poirier
authors.forename: E
authors.initials: E
authors.lastname: Garin
authors.forename: C
authors.initials: C
authors.lastname: Derrien
authors.forename: A
authors.initials: A
authors.lastname: Devillers
authors.forename: A
authors.initials: A
authors.lastname: Moisan
authors.forename: P
authors.initials: P
authors.lastname: Bourguet
authors.forename: D
authors.initials: D
authors.lastname: Maugendre
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D017719:Diabetic Foot / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000209:etiology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate