[Common variable immunodeficiency. Report of 2 cases].
We report two cases with common variable immunodeficiency. Both of them had gammaglobulin concentration lower than 300 mg/dL and evolved differently. The first one had three pneumonic episodes that responded satisfactorily to antibiotics. Today, this patient presents only two or three sinusitis clinical schemes per year, and has a good response to treatment. The second one has a bad evolution and presents hematological problems like thrombocytopenia and neutropenia. She also suffers lymphoid nodular hyperplasia in the intestinal tract and atrophy in the intestinal. These cases illustrate the wide clinical, immunological and genetic variety of the syndrome.
Montero Mora
Patricia
P
Salas Benítez
Hugo
H
Tinajero Castañeda
Olga Adriana
OA
Guidos Fogelbach
Gullermo
G
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000235:genetics / Q000276:immunology; D003967:Diarrhea / Q000209:etiology; D004198:Disease Susceptibility; D005260:Female; D000069585:Filgrastim; D018740:Genetic Heterogeneity; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology; D019310:Pseudolymphoma / Q000209:etiology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications; D011994:Recombinant Proteins; D012008:Recurrence; D012852:Sinusitis / Q000188:drug therapy / Q000209:etiology; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology; D005719:gamma-Globulins / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D005719:gamma-Globulins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim