title: Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes.
abstract: Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
authors.affiliation: IIB Fundación Campomar, IIB FCEyN, University of Buenos Aires and IIBBA-CONICET, Buenos Aires, Argentina.
authors.forename: María G
authors.initials: MG
authors.lastname: Thomas
authors.forename: Tomás A
authors.initials: TA
authors.lastname: Santa Coloma
authors.forename: Jorge
authors.initials: J
authors.lastname: Correale
authors.forename: Graciela L
authors.initials: GL
authors.lastname: Boccacci
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009281:Naphthalenes / Q000494:pharmacology*; D009836:Oligodendroglia / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001381:Azepines; D004791:Enzyme Inhibitors; D009281:Naphthalenes; C056218:ML 9; C070571:ML 7; D009219:Myosin-Light-Chain Kinase