title: Constituents of the fruits and leaves of Euodia daniellii.
abstract: Four flavonoid glycosides, flavaprin (7), evodioside B (8), vitexin (11), and hesperidin (12), as well as the coumarins bergapten (1), xanthotoxin (2), and isopimpinellin (3), the lignan simplexoside (10), the steroids beta-sitosterol (4) and daucosterol (5), the limonoids isolimonexic acid (6) and limonin (9), and uracil (13) and myo-inositol (14) have been isolated from Euodia daniellii. The structures of these compounds were established from spectral data. Among the isolates, bergapten showed cyclooxygenase-2 inhibitory activity with an IC50 value of 6.2 microg/ml. Flavonoids isolated from this plant exhibited no cytotoxic activity against the human tumor cell lines, A549, SKOV-3, SKMEL-2, XF498, and HCT15.
authors.affiliation: Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea,
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Yoo
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Chong-Ock
authors.initials: CO
authors.lastname: Lee
mesh_terms: D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D010936:Plant Extracts