[Impairment effect of diabetes mellitus combined with hypertension on artery vasodilation].
OBJECTIVE
This study was to assess the relationship between endothelial dysfunction, and to explore smooth muscle dysfunction and the synergic action of different risk factors on impairment of artery vasodilation.


METHODS
Using high resolution ultrasound, the dilator response of the brachial artery to 500 micrograms of sublingual nitroglycerin (NTG) was measured in patients with Type 2 diabetes mellitus (Group 1), patients with hypertension (Group 2), patients with both Type 2 diabetes mellitus and hypertension (Group 3), and control subjects (Group 4). Blood pressure, total serum cholesterol, basic vessel size, and flow-mediated endothelium-dependent dilation (EDD) were also measured.


RESULTS
On multiple linear regression analysis, a reduced vasodilator response to NTG was positively correlative with reduced EDD(P < 0.001). EDD was reduced in Group 1 (P < 0.05), Group 2 (P < 0.01) and Group 3(P < 0.01) compared to Group 4, but only Group 3 showed significantly reduced dilator response to NTG(P < 0.00).


CONCLUSIONS
The impairment of vasodilator response to exogenous NO is associated with reduced EDD. More risk factors may aggravate impairment of vasodilation.
Ma
L L
LL
Department of Cardiology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Zhao
S P
SP
Li
J
J
D000368:Aged; D001916:Brachial Artery / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism; D014664:Vasodilation / Q000502:physiology*
D009569:Nitric Oxide