title: Evidence for a positive association between pulmonary function and wine intake in a population-based study.
abstract: BACKGROUND
  Lung function is a strong predictor of cardiovascular and all-cause mortality. Previous studies suggest that alcohol exposure may be linked to impaired pulmonary function through oxidant-antioxidant mechanisms. Alcoholic beverages may be an important source of oxidants and antioxidants. We analyzed the relation of beverage-specific alcohol intake with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in a random sample of 1555 residents of Western New York, USA.
  
  
  METHODS
  We expressed pulmonary function as percent of predicted normal FEV1 (FEV1%) and FVC (FVC%) after adjustment for height, age, gender, and race. To obtain information on alcohol intake we used a questionnaire that reliably queries total alcohol and beverage-specific recent (past 30 days) and lifetime alcohol consumption.
  
  
  RESULTS
  Using multiple linear regression analysis after adjustment for covariates (pack-years of smoking, weight, smoking status, education, nutritional factors, and for FEV1%, in addition, eosinophil count), we observed no significant correlation between total alcohol intake and lung function. However, we found positive associations of recent and lifetime wine intake with FEV1% and FVC%. When we analyzed white and red wine intake separately, the association of lung function with red wine was weaker than with white wine.
  
  
  CONCLUSIONS
  While total alcohol intake was not related to lung function, wine intake showed a positive association with lung function. Although we cannot exclude residual confounding by healthier lifestyle in wine drinkers, differential effects of alcoholic beverages on lung health may exist.
authors.affiliation: Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214-3000, USA. HJS@bufalo.edu
authors.forename: Holger J
authors.initials: HJ
authors.lastname: Schünemann
authors.forename: Brydon J B
authors.initials: BJ
authors.lastname: Grant
authors.forename: Jo L
authors.initials: JL
authors.lastname: Freudenheim
authors.forename: Paola
authors.initials: P
authors.lastname: Muti
authors.forename: Susan E
authors.initials: SE
authors.lastname: McCann
authors.forename: Deepa
authors.initials: D
authors.lastname: Kudalkar
authors.forename: Malathi
authors.initials: M
authors.lastname: Ram
authors.forename: Tom
authors.initials: T
authors.lastname: Nochajski
authors.forename: Marcia
authors.initials: M
authors.lastname: Russell
authors.forename: Maurizio
authors.initials: M
authors.lastname: Trevisan
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012129:Respiratory Function Tests; D013147:Spirometry / Q000379:methods; D014797:Vital Capacity / Q000502:physiology; D014920:Wine