EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein.
The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.
Callebaut
Isabelle
I
Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 05 Paris Cedex, France. Isabelle.Callebaut@lmcp.jussieu.fr
Mignotte
Vincent
V
Souchet
Michel
M
Mornon
Jean Paul
JP
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D030562:Databases, Protein / Q000706:statistics & numerical data; D007313:Insecta; D008322:Mammals; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid
D029742:Caenorhabditis elegans Proteins; D008565:Membrane Proteins; C422043:ced-1 protein, C elegans; C110128:Neu1 protein, mouse; D009439:Neuraminidase