[Irradiated porcine skin impregnated with fluorine and silver covered by autogenous granule skin graft for treating severe burn injury].
OBJECTIVE
To study the feasibility of using irradiated porcine skin impregnated with fluorine and silver covered by autogenous skin granule graft in the treatment of severe burn injury.


METHODS
Autogenous split-thick skin grafts were cut into small pieces (<1 mm3), which were transferred onto the sheet of porcine skin mounted with a layer of Xinnaxing ointment (2 mm in thickness). After eschar removal, the burn wound was covered with the prepared porcine skin, sutured and fixed with small holes at the lower site for drainage. The growth of autogenous granule skin was then observed and the criteria for therapeutic effect evaluation drafted.


RESULTS
The layer of Xinnaxing ointment on the the porcine skin improved the adhesion of the autogenous small skin grafts, therefore full use could be made of the donor skin source. In the 15 patients receiving this treatment, the graft-covered area was (12.3+/-3.5) % that of the wound, with the donor-recipient area ratio of 1: (11.0+/-2.7) and subsequent healing time of 27.5+/-5.5 d. Primary healing was achieved in 9 cases, and secondary healing in 6, demonstrating similar clinical effect to that of allo-skin grafting.


CONCLUSIONS
The method is easy and economic, which saves autogenous skin source and produces satisfactory clinical effect.
He
Guo
G
People's Hospital of Meizhou City, Meizhou 514031, China.
Lin
Xin-hua
XH
Zhong
Quan
Q
Zeng
Xi-ying
XY
Chen
Ai-ling
AL
D000328:Adult; D000818:Animals; D001684:Biological Dressings; D002056:Burns / Q000601:surgery*; D005260:Female; D005461:Fluorine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012834:Silver / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects; D016038:Skin Transplantation / Q000379:methods*; D013552:Swine; D014182:Transplantation, Autologous
D005461:Fluorine; D012834:Silver