Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines.
T cell mediated immunity and in particular CD8+ T cells are pivotal for the control of most viral infections. T cells exclusively exert their antiviral effect through close cellular interaction with relevant virus-infected target cells in vivo. It is therefore imperative that efficient mechanisms exist, which will rapidly direct newly generated effector T cells to sites of viral replication. In the present report we have reviewed our present knowledge concerning the molecular interactions, which are important in targeting of effector CD8+ T cells to sites of viral infection.
Thomsen
Allan Randrup
AR
Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. a.r.thomsen@immi.ku.dk
Nansen
Anneline
A
Madsen
Andreas Nygaard
AN
Bartholdy
Christina
C
Christensen
Jan Pravsgaard
JP
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D018925:Chemokines / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000276:immunology; D019707:Receptors, Chemokine / Q000378:metabolism; D019087:Selectins / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000821:virology*; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016023:Integrins; D019707:Receptors, Chemokine; D019087:Selectins