Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system.
Certain types of human papillomaviruses have been etiologically associated with malignant lesions, most notably with cervical cancer. The major oncoproteins of these cancer-associated viruses are encoded by the viral E6 and E7 genes. Thorough characterization of these oncoproteins and their interaction with cellular proteins has shown that both E6 and E7 exploit the ubiquitin-proteasome system to degrade and, thus, to functionally inactivate negative cell-regulatory proteins including members of the p110(RB) family and p53. This act of piracy is assumed to contribute to both the efficient propagation of HPVs and HPV-induced carcinogenesis.
Scheffner
Martin
M
Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Joseph-Stelzmann-Str 52, 50931 Köln, Germany. martin.scheffner@uni-koeln.de
Whitaker
Noel J
NJ
D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005260:Female; D006801:Humans; D008025:Ligases / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity; D046988:Proteasome Endopeptidase Complex; D016160:Retinoblastoma Protein / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000821:virology*
D009097:Multienzyme Complexes; D009856:Oncogene Proteins, Viral; D016160:Retinoblastoma Protein; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D008025:Ligases