[Signal transduction of alpha 1-adrenoceptors].
alpha 1-adrenoceptors activate multiple signal transduction pathways. In addition to the classic inositol phosphates-Ca2+ system and diacylglycerol-protein kinase C system, the phospholipase A2-arachidonic acid system, the tyrosine kinase phosphorylation system, the adenylate cyclase-cAMP system etc. were also involved. These signal transduction cascades interact complicatedly with each other as a network. The activation of one signal system can initiate, potentiate or inhibit other systems. They play pivotal role in diversified physiological and pathophysiological processes. Different alpha 1-adrenoceptor subtypes activate different signal transduction pathways. In some experiments, however, the differences are due to the different tissues or cells used.
Li
H W
HW
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing 100083.
Han
Q D
QD
D002118:Calcium / Q000378:metabolism; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D015398:Signal Transduction
D007295:Inositol Phosphates; D018340:Receptors, Adrenergic, alpha-1; D011505:Protein-Tyrosine Kinases; D002118:Calcium