title: [Association of the relationship between HLA-DQB1 alleles and major beta-thalassemia in 42 guangdong Chinese].
abstract: To investigate the relationship between HLA-DQB1* alleles and major beta-thalassemia, the HLA-DQB1* loci typing was performed with polymerase chain reaction-sequence specific primer (PCR-SSP) in 42 unrelated (unconsanguineous) patients with major beta-thalassemia and 45 normal control individuals in Guangdong Province. Results showed that the frequency of HLA-DQB1*06 allele in patient group (19.0%) was higher than that in the control group (4.4%) kappa(2) = 8.961, p < 0.01). Our data suggests that HLA-DQB1*06 allele is associated with pathogenesis of the major beta-thalassemia in Guangdong area.
authors.affiliation: Lingnan Cord Blood Bank, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Bao
authors.forename: Chun
authors.initials: C
authors.lastname: Chen
authors.forename: Jian-Pei
authors.initials: JP
authors.lastname: Fang
authors.forename: Shao-Liang
authors.initials: SL
authors.lastname: Huang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D017086:beta-Thalassemia / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen