title: [Use of Panzytrat in the replacement therapy of exocrine pancreatic insufficiency (an analytical review)].
abstract: The development of new drug formulations of pancreatine based on the principle of microdosage with a pH-sensitive coating produced the most demonstrative clinical result--a considerable increase in duration and quality of life of patients with chronic pancreatitis and cystofibrosis, most of which are children. Clinical studies confirmed high efficiency and safety of Panzytrat in open and double blind comparative clinical studies with the participation of 4,557 patients with chronic pancreatitis, mucoviscidosis, and pancreathogenous digestion disorders. In addition to the above-mentioned symptoms, indications for application of Panzytrat also include any clinical symptoms of the pancreas relative excretory insufficiency, in particular, states after oncological diseases and surgical operations (obstruction of ducts, resection, cholecystectomy, etc.) up to a failure to adhere to a diet and overeating.
authors.affiliation: Moscow State Medical Stomatological University.
authors.forename: E I
authors.initials: EI
authors.lastname: Karamysheva
authors.forename: E G
authors.initials: EG
authors.lastname: Lobanova
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000188:drug therapy; D010188:Exocrine Pancreatic Insufficiency / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D010194:Pancreatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy
chemical_list: D005765:Gastrointestinal Agents; D010194:Pancreatin