title: Prevalence of hyperesthesia detected by current perception threshold test in subjects with glucose metabolic impairments in a community.
abstract: OBJECTIVE
  Recent studies reported that hyperesthesia may be an indicator of early diabetic polyneuropathy. Using the current perception threshold (CPT) test, which stimulates peripheral sensory nerve fibers by three different frequencies (2,000, 250, and 5 Hz), we investigated the relationship between hyperesthesia and glucose metabolic impairment in a community.
  
  
  METHODS
  The number of subjects, aged 40 to 79 years, was 2,074. The CPT values at each frequency were classified into three categories (hyperesthesia, normal, and hypoesthesia). Subjects were also subgrouped into three groups (normal, insulin resistance, and diabetes) according to glucose metabolic status, and those with hypoesthesia at each frequency were excluded in the analyses.
  
  
  RESULTS
  The prevalence of hyperesthesia at 2,000, 250, and 5 Hz in male diabetic subjects were 14.1, 15.6, and 7.7%, respectively, and 22.2, 24.5, and 16.4% respectively in female diabetic subjects. In logistic regression analysis adjusted for age, females with diabetes showed a significantly high odds ratio (OR) for hyperesthesia at 2,000 Hz (OR, 2.42; 95% confidence interval (95%CI), 1.18 to 4.97) and 250 Hz (OR, 2.65; 95%CI, 1.31 to 5.37). In male diabetic subjects, a significantly high odds ratio for hyperesthesia was seen at 250 Hz (OR, 2.09; 95%CI, 1.07 to 4.05).
  
  
  CONCLUSIONS
  Our results suggested that hyperesthesia may emerge coupled with developing diabetes, supporting the precedent hypothesis.
authors.affiliation: Department of Public Health, Nagoya City University Medical School, Nagoya.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takekuma
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.forename: Naoakira
authors.initials: N
authors.lastname: Niino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
mesh_terms: D000328:Adult; D000368:Aged; D048909:Diabetes Complications; D003943:Diagnostic Techniques, Neurological; D005260:Female; D018149:Glucose Intolerance / Q000150:complications*; D006801:Humans; D006941:Hyperesthesia / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012684:Sensory Thresholds; D012737:Sex Factors; D013383:Suburban Population; D014110:Touch / Q000502:physiology*