[Specifics of the neurotensin effect on rat motor responses to positive and negative conditioned stimuli].
Comparative analysis of effects of neurotensin microinjections into caudate nucleus and substantia nigra on thirst-motivated motor conditioned reactions in rats, was performed. The microinjections facilitated extinction of conditioned reactions in response to negative stimuli and did not affect realization of responses to positive conditioned signals. Behavioral effects of neurotensine in rats are connected with the normalising of motivational and emotional states of animals and may be explained by restoration of monoaminergic systems interaction.
Shugalev
N P
NP
Brain Research Institute of the Russian Acad. Med. Sci., 105064, Moscow, 5 Per. Obukha, Russia.
Iamshchikova
N G
NG
Ol'shanskiĭ
A S
AS
Stavrovskaia
A V
AV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009496:Neurotensin / Q000494:pharmacology*; D010812:Physical Stimulation; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D009496:Neurotensin