title: Adverse effects of supplemental L-arginine in atherosclerosis: consequences of methylation stress in a complex catabolism?
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000502:physiology; D001120:Arginine / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000178:diet therapy* / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D002384:Catalysis / Q000187:drug effects; D019587:Dietary Supplements / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D006710:Homocysteine / Q000378:metabolism; D008745:Methylation / Q000187:drug effects; D008780:Methyltransferases / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D019001:Nitric Oxide Synthase / Q000172:deficiency / Q000378:metabolism / Q000502:physiology; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D013379:Substrate Specificity / Q000187:drug effects / Q000502:physiology
chemical_list: D001057:Apolipoproteins E; D006710:Homocysteine; D001120:Arginine; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496317:Nos2 protein, mouse; C496315:Nos3 protein, mouse; D008780:Methyltransferases