title: [Complex assessment of efficacy and tolerance of metoprolol CR/ZOK in treating hypertension].
abstract: OBJECTIVE
  To study efficacy and tolerance of betaloc ZOK (Astra-Zeneca, UK) in patients with stage I-II (WHO classification) essential hypertension.
  
  
  METHODS
  27 patients were enrolled in the study (13 men and 14 women, mean age 40.6 +/- 1.57 years). Complete physical examination, ambulatory blood pressure monitoring, assessment of central hemodynamics, microcirculation were made before the treatment and on the treatment week 8.
  
  
  RESULTS
  Monotherapy with betalok ZOK (50-100 mg/day) resulted in a significant lowering of mean daily, day and night systolic and diastolic arterial pressure. Variability index was reduced, circadian rhythm of blood pressure did not change. 28% had to take diuretics (arifon or hypotiazide).
  
  
  CONCLUSIONS
  Betaloc ZOK (50-100 mg) is highly effective in patients with mild to moderate essential hypertension.
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.forename: L A
authors.initials: LA
authors.lastname: Strizhakov
authors.forename: V I
authors.initials: VI
authors.lastname: Pavlov
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D008790:Metoprolol