Advances in research of the inflammatory response: the importance of toll-like receptors.
The innate immune system provides the first line of defence against invading pathogens. Cells that mediate the innate immune response express a variety of receptors that permit recognition of pathogen-associated motifs, subsequently resulting in a cascade of responses that initiates inflammation. Recently, the members of the Toll-like receptor family (TLR) have emerged as key receptors responsible not only for the detection of a variety of microbial cell-wall components and bacterial DNA but also for the initiation of signal transduction events eventually leading to the production of various proinflammatory mediators.
Knapp
Sylvia
S
Laboratory of Experimental Internal Medicine, Academic Medical Centre, Room G2-108, University of Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands. s.knapp@amc.uva.nl
Branger
Judith
J
van der Poll
T
T
D000818:Animals; D004269:DNA, Bacterial / Q000276:immunology; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology*; D051193:Toll-Like Receptors
D004269:DNA, Bacterial; D029721:Drosophila Proteins; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors