title: [Biodistribution and metabolism of radio-iodinated IBZM in rats].
abstract: The aim of this study was to assess the bio-distribution and metabolic behavior of radio-iodinated IBZM in rats. Routine and improved technologies were used. The results showed that the radio-iodinated IBZM had favorable bio-distribution and metabolic behavior. The radio-distribution was high and the radio-iodinated IBZM remained long in striatum where no metabolic by-products manifested at 30 minutes after injection. These suggested that radio-iodinated IBZM is an excellent dopamine D2 receptor imaging agent for SPECT in humans, and it is stressed that thyroid must be blocked by iodine during the study of imaging.
authors.affiliation: Department of Nuclear Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: G
authors.initials: G
authors.lastname: Cao
authors.forename: T
authors.initials: T
authors.lastname: Tan
mesh_terms: D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D011759:Pyrrolidines / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide