[Linker histones: conformational changes and the role in the structural organization of chromatin].
Histones, linker histones of the H1 family, their postsyntetic modifications, DNA-histone H1 interaction are reviewed. A question of protein change in spermatogenesis at the formation of inactive nucleus with high degree of DNA density is considered. Special attention was paid to sperm-specific histones of the H1 family of sperm cells. Their role in organization of high-order chromatin structure of sperm cells is discussed. Also, results of different studies on the structural organization of chromatin (nucleosomes, 30-nm fibers, chromatin loops and metaphase chromosomes) are discussed.
Chikhirzhina
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EV
Institute of Cytology RAS, St. Petersburg. chikhir@hotmail.com
Vorob'ev
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VI
D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006657:Histones / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D011487:Protein Conformation; D013094:Spermatozoa / Q000648:ultrastructure
D002843:Chromatin; D006657:Histones; D004247:DNA