Oral tramadol for the treatment of pain of 7-30 days' duration in children.
This open-label, multicenter trial was designed to determine the safety profile and analgesic efficacy of tramadol for the treatment of painful conditions lasting 7-30 days in 7-16-yr-old children. We found that tramadol 1-2 mg/kg per os every 4-6 h (maximal dose = 8 mg x kg(-1). d(-1), not to exceed 400 mg/d) is a safe and effective analgesic in this patient population.
Rose
John B
JB
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Pennsylvania 19104, USA. rose@email.chop.edu
Finkel
Julia C
JC
Arquedas-Mohs
Adriano
A
Himelstein
Bruce P
BP
Schreiner
Mark
M
Medve
Robert A
RA
D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010349:Patient Compliance; D018401:Sample Size; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D014147:Tramadol