Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer.
Minna
John D
JD
Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. john.minna@utsouthwestern.edu
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects*; D002273:Carcinogens; D004789:Enzyme Activation; D004847:Epithelial Cells / Q000187:drug effects*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D009538:Nicotine / Q000009:adverse effects*; D009602:Nitrosamines / Q000009:adverse effects; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D011978:Receptors, Nicotinic / Q000096:biosynthesis*
D002273:Carcinogens; D009602:Nitrosamines; D011518:Proto-Oncogene Proteins; D011978:Receptors, Nicotinic; D009538:Nicotine; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; C008655:N'-nitrosonornicotine