title: Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects.
abstract: Gastric emptying is a determinant of the postprandial glycemic and cardiovascular responses to oral carbohydrate. We evaluated the effects of a solid meal on gastric emptying and the glycemic and cardiovascular responses to oral glucose in healthy older subjects. Ten subjects aged 72.1 +/- 1.9 yr were studied. Each subject had measurements of gastric emptying, blood glucose, serum insulin, blood pressure, and heart rate after ingestion of a 50-g glucose drink (300 ml) with (mixed meal) or without (liquid only) a solid meal (300 g ground beef). Gastric emptying of liquid was initially slightly more rapid (P < 0.05) after the mixed meal compared with liquid only at 5 min (92.0 +/- 1.5 vs. 96.0 +/- 1.3%) and much slower (P < 0.05) after 120 min. The time to peak blood glucose was less (39.0 +/- 4.0 vs. 67.5 +/- 10.3 min; P < 0.01) and blood glucose subsequently lower (P < 0.01) after the mixed meal. The increase in serum insulin was greater (P < 0.001) after the mixed meal. Blood pressure fell (P < 0.05) in the first 30 min, with no difference between the two meals. Increase in heart rate after both meals (P < 0.005), was greater (P < 0.05) after the mixed meal. The presence of a noncarbohydrate solid meal had discrepant effects on early and subsequent emptying of a nutrient liquid, which affects postprandial glycemia and increased heart rate.
authors.affiliation: Department of Clinical Pharmacology, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia.
authors.forename: Melanie K
authors.initials: MK
authors.lastname: Berry
authors.forename: Antonietta
authors.initials: A
authors.lastname: Russo
authors.forename: Judith M
authors.initials: JM
authors.lastname: Wishart
authors.forename: Anne
authors.initials: A
authors.lastname: Tonkin
authors.forename: Michael
authors.initials: M
authors.lastname: Horowitz
authors.forename: Karen L
authors.initials: KL
authors.lastname: Jones
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007022:Hypotension / Q000503:physiopathology; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D019518:Postprandial Period
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose