The role of nitric oxide and lipid peroxidation in patients with Plasmodium vivax malaria.
In this study, we investigated the role of nitric oxide metabolism and lipid peroxidation in patients with P. vivax malaria. The levels of nitrite and nitrate were analyzed using a procedure based on the Griess reaction and malondialdehyde levels which index of lipid peroxidation was determined by thiobarbituric acid reaction. The levels of nitrite/nitrate and malondialdehyde in patients were higher than controls and found to be statistically significant (p < 0.001). We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria. This present study shows that lipid peroxidation occurs in P. vivax malaria. The levels of nitric oxide are associated with lipid peroxidation in this disease.
Polat
G
G
Mersin University, Medical Faculty, Department of Biochemistry, Mersin, Turkey. gurbuzp@hotmail.com
Aslan
G
G
Eskandari
G H
GH
Delialioğlu
N
N
Bağdatoğlu
O
O
Atik
U
U
D000818:Animals; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D016780:Malaria, Vivax / Q000097:blood / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000502:physiology*; D009573:Nitrites / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D008315:Malondialdehyde