Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed pigs.
OBJECTIVE
To determine the effects of hyperdynamic endotoxemia on the motility of the small intestine.


BACKGROUND
Motility disorders of the gastrointestinal tract are a common complication of sepsis. It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying diarrhea frequently observed.


METHODS
Pigs were infused with lipopolysaccharide for a 24-hour period. During this fasting period jejunal motility was measured using ambulatory manometry. One and 4 days after cessation of endotoxin, pigs were enterally fed, and again motility was recorded.


RESULTS
Hyperdynamic endotoxemia was achieved in this model. Manometric pressure recordings revealed that endotoxin infusion accelerated the migrating motor complex (MMC) migration along the jejunum. Also, a simultaneous increase in MMC cycling frequency was observed in the endotoxin-treated group. Elevated MMC migration velocity and cycling frequency were maintained the following day after endotoxin during feeding and returned to basal values 4 days after endotoxin.


CONCLUSIONS
A small dose of continuously infused endotoxin significantly provokes jejunal motility disturbances that may contribute to diarrhea.
Bruins
Maaike J
MJ
Department of Surgery, Maastricht University, Maastricht, The Netherlands. m.bruins@chem.leidenuniv.nl
Luiking
Yvette C
YC
Soeters
Peter B
PB
Akkermans
Louis M A
LM
Deutz
Nicolaas E P
NE
D000818:Animals; D001783:Blood Flow Velocity; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000503:physiopathology*; D004731:Endotoxins / Q000494:pharmacology*; D004750:Enteral Nutrition; D005215:Fasting; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology; D007583:Jejunum / Q000187:drug effects / Q000503:physiopathology*; D008365:Manometry; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D012016:Reference Values; D013552:Swine
D004731:Endotoxins