[Significance of MOC-31 and CD56 detection in human lung carcinoma tissues].
OBJECTIVE
The majority of research found that the positive rate of MOC-31 is higher in lung carcinoma than that in pleural mesothelioma. So MOC-31 is regarded as an important factor in differentiating diagnosis of lung carcinoma from pleural mesothelioma. But there are also few contrary reports. CD56 (neural cell adhesion molecule) is a sensitive factor in diagnosis of small cell lung carcinoma (SCLC), but the reports about its diagnostic sensitivity in non-small cell lung carcinoma (NSCLC) are different. This study was conducted to investigate the significance of MOC-31 and CD56 in diagnosis of human lung carcinoma.


METHODS
Immunohistochemical method (S-P) was used to detect MOC-31 and CD56 expression in 92 cases of lung carcinoma.


RESULTS
The positive rate of MOC-31 in lung carcinoma was 98.9% (91/92), among which, 98.6% (72/73) in NSCLC, 100% (19/19) in SCLC; the positive expression rate of CD56 in lung carcinoma was 30.4% (28/92), among which, 12.3% (9/73) in NSCLC, 100% (19/19) in SCLC. MOC-31 and CD56 expressions in adjacent lung tissue and normal lung tissue were negative.


CONCLUSIONS
MOC-31 is an antibody which is highly sensitive and peculiar to lung carcinoma, whereas CD56 only showed sensitive to SCLC. Therefore, combined determination of MOC-31 and CD56 is more useful than that of single item in diagnosing SCLC.
Huang
Ying-gui
YG
Department of Pathology, Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, P. R. China.
Xu
Yan-yun
YY
Zheng
Zhao-hui
ZH
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000032:analysis*; D000071858:Epithelial Cell Adhesion Molecule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D019002:CD56 Antigen; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule