[The relationship of cellular DNA content with clinical stage and biological features of colorectal cancer].
The purpose of this study was to explore the relationship of cellular DNA content with clinical stage and biological features of cancer. Flow cytometry was performed on fresh specimens from 86 patients from 1997 to 1998. Forty-five (53.3%) specimens were found to contain cells with abnormal DNA (DNA nondiploidy). Although none of the sex, age, site, differentiation variables correlated with flow cytometric DNA ploidy, nondiploidy was associated with Dukes' stage and lymph node metastasis. Duke's A stage tumors were more frequently diploid than were more advanced tumors, but no difference between Duke's B, C and D stages were observed. These findings suggest that ploidy is associated with some pathological factors.
Zou
L
L
Department of Biotherapy for Cancer, First Affiliated Hospital, WCUMS, Chengdu 610041.
Mao
Y
Y
Lei
S
S
Wei
Y
Y
Zhao
X
X
Kan
B
B
Jiang
Y
Y
Peng
F
F
Wang
Q
Q
Tian
L
L
Yang
L
L
Liu
J
J
D000368:Aged; D000782:Aneuploidy; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D004273:DNA, Neoplasm