title: Rapidly progressive glomerulonephritis in adult Nigerians: a report of 4 cases.
abstract: The clinicopathological features of rapidly progressive glomerulonephritis (RPGN) were studied in 4 young adult Nigerians who presented with acute GN. There was a predilection for males with a male to female ratio of 3:1. Hypertension. nephrotic-range albuminuria, haematuria granular and cellular urinary casts, and a rapid progression to severe renal failure or death were the findings in all four patients. Renal biopsy revealed histological features compatible with findings in RPGN in all the patients, including the presence of crescents and epithelial cellular proliferation. The study shows that the early development of hypertension and deterioration of renal function in patients with features of acute glomerulonephritis should arouse suspicion of a rapidly progressive GN whose course could be altered by appropriate therapeutic measures, some of which are highlighted.
authors.affiliation: Renal Unit, Department of Medicine, University College Hospital, Ibadan, Nigeria.
authors.forename: A
authors.initials: A
authors.lastname: Arije
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Kadiri
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D004232:Diuretics / Q000627:therapeutic use; D004487:Edema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007866:Leg / Q000098:blood supply; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009549:Nigeria; D011654:Pulmonary Edema / Q000209:etiology; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D012709:Serum Albumin; D003404:Creatinine