Successful rituximab treatment of an EBV-related lymphoproliferative disease arising after autologous transplantation for angioimmunoblastic T-cell lymphoma.
Rituximab treatment of B-cell lymphoproliferative disease following transplantation is being evaluated. We describe an Epstein-Barr virus-related B-cell lymphoma that developed in a 55-year-old woman, one year after autologous transplantation for relapsing angioimmunoblastic T-cell lymphoma. Complete remission was achieved after four cycles of rituximab and reduced-dose CHOP. This case is discussed in the context of severe immunodepression. Monoclonal anti-CD20 antibodies might restore a balance between T-cell immunosurveillance and EBV proliferation in B-cells,
Park
Sophie
S
Laboratoire d'Hématologie, Hôpital Saint-Louis AP/HP, Paris, France. parksophie@yahoo.com
Noguera
Maria-Elena
ME
Brière
Josette
J
Feuillard
Jean
J
Cayuela
Jean-Michel
JM
Sigaux
François
F
Brice
Pauline
P
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000209:etiology; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000628:therapy* / Q000821:virology; D016399:Lymphoma, T-Cell / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000628:therapy / Q000821:virology; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D000069283:Rituximab; D014182:Transplantation, Autologous
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab