Signal transduction and neurosurvival in experimental models of brain injury.
Brain injury and neurodegenerative disease are linked by their primary pathological consequence-death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.
Butler
T L
TL
Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Kassed
C A
CA
Pennypacker
K R
KR
D000818:Animals; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008962:Models, Theoretical; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D006133:Growth Substances; D014157:Transcription Factors