title: Effects of diabetes and gender on mechanical properties of the arterial system in rats: aortic impedance analysis.
abstract: We determined the effects of diabetes and gender on the physical properties of the vasculature in streptozotocin (STZ)-treated rats based on the aortic input impedance analysis. Rats given STZ 65 mg/kg i.v. were compared with untreated age-matched controls. Pulsatile aortic pressure and flow signals were measured and were then subjected to Fourier transformation for the analysis of aortic input impedance. Wave transit time was determined using the impulse response function of the filtered aortic input impedance spectra. Male but not female diabetic rats exhibited an increase in cardiac output in the absence of any significant changes in arterial blood pressure, resulting in a decline in total peripheral resistance. However, in each gender group, diabetes contributed to an increase in wave reflection factor, from 0.47 +/- 0.04 to 0.84 +/- 0.03 in males and from 0.46 +/- 0.03 to 0.81 +/- 0.03 in females. Diabetic rats had reduced wave transit time, at 18.82 +/- 0.60 vs 21.34 +/- 0.51 msec in males and at 19.63 +/- 0.37 vs 22.74 +/- 0.57 msec in females. Changes in wave transit time and reflection factor indicate that diabetes can modify the timing and magnitude of the wave reflection in the rat arterial system. Meanwhile, diabetes produced a fall in aortic characteristic impedance from 0.023 +/- 0.002 to 0.009 +/- 0.001 mmHg/min/kg/ml in males and from 0.028 +/- 0.002 to 0.014 +/- 0.001 mmHg/min/kg/ml in females. With unaltered aortic pressure, both the diminished aortic characteristic impedance and wave transit time suggest that the muscle inactivation in diabetes may occur in aortas and large arteries and may cause a detriment to the aortic distensibility in rats with either sex. We conclude that only rats with male gender diabetes produce a detriment to the physical properties of the resistance arterioles. In spite of male or female gender, diabetes decreases the aortic distensibility and impairs the wave reflection phenomenon in the rat arterial system.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan. kcchang@ha.mc.ntu.edu.tw
authors.forename: Kuo-Chu
authors.initials: KC
authors.lastname: Chang
authors.forename: Kwan-Lih
authors.initials: KL
authors.lastname: Hsu
authors.forename: Yung-Zu
authors.initials: YZ
authors.lastname: Tseng
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology* / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors