[Effects of total flavones of metasequosia on left ventricular hypertrophy due to pressure overload in rats].
OBJECTIVE
To determine the preventive and regressive effects of total flavones of metasequosia (TFM) on left ventricular hypertrophy in rats.


METHODS
Left ventricular hypertrophy was inducedin by partial ligation of abdominal aorta. The rats were given ig TFM(4, 40, 400 mg.kg-1.d-1) for six weeks.


RESULTS
TFM markedly reduced the HW/BW, LVW/BW, myofibril diameter and Ca2+ content in left ventricles but the systolic blood pressure (SBP) in rats wasn't obviously influenced.


CONCLUSIONS
TFM can prevent and reverse the left ventricular hypertrophy due to pressure overload in rats. The mechanism may be related to its calcium antagonistic properties.
Zeng
J X
JX
Dept of Pharmacology, Hubei Medical University, Wuhan 430071, Hubei, China.
Liu
W W
WW
Shi
M J
MJ
Yang
X R
XR
Mi
L X
LX
Lu
Y Y
YY
Zheng
Q A
QA
Wang
H Y
HY
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism*; D032462:Cycadopsida / Q000737:chemistry; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D005419:Flavonoids; D002118:Calcium