title: New nitrogen mustards structurally related to (L)-carnitine.
abstract: Enantiopure nitrogen mustards which mimic (L)-carnitine framework are prepared by a multi-step synthesis from the (R)-di-tert-butyl malate and their antitumor properties evaluated.
authors.affiliation: ENSCM, Laboratoire de Chimie Biomoléculaire, UMR 5032, 8 Rue de l'Ecole Normale, 34296 Montpellier Cédex 05, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Faissat
authors.forename: Katja
authors.initials: K
authors.lastname: Martin
authors.forename: Claude
authors.initials: C
authors.lastname: Chavis
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montéro
authors.forename: Marc
authors.initials: M
authors.lastname: Lucas
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000494:pharmacology; D002331:Carnitine / Q000031:analogs & derivatives*; D006801:Humans; D020128:Inhibitory Concentration 50; D008293:Malates / Q000737:chemistry; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008293:Malates; D009588:Nitrogen Mustard Compounds; C030298:malic acid; D002331:Carnitine