Stereoselective pharmacokinetics of amlodipine in elderly hypertensive patients.
Amlodipine is a dihydropyridine calcium antagonist and is widely used for the treatment of cardiovascular diseases. Amlodipine has two stereoisomers [R(+), S(-)], and only the S(-) isomer exerts vasodilating action. In this preliminary study, amlodipine (5 mg) was given to three elderly hypertensive patients once daily for 10 days. Blood samples were obtained, and serum concentrations of R(+)- and S(-)-amlodipine were measured by a gas chromatographic method. The R(+)/S(-) ratio of plasma amlodipine in these elderly subjects was greater than that reported in young subjects. These results suggest that the influence of aging on the pharmacokinetic profiles might differ between the R(+)- and S(-)-isomers of amlodipine.
Ohmori
Masami
M
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Arakawa
Masashi
M
Harada
Kazuhiro
K
Takasaki
Hideaki
H
Hifumi
Senshu
S
Miyamori
Isamu
I
Fujimura
Akio
A
D000368:Aged; D017311:Amlodipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D013237:Stereoisomerism
D002121:Calcium Channel Blockers; D017311:Amlodipine