[Changes of lipoprotein lipase and hepatic lipase and their significance in gallstone formation in rabbit model].
This experiment was made to investigate the changes of lipoprotein lipase(LPL) and hepatic lipase (HL) activity and their effects on gallstone formation in rabbit model in which the stones were induced by high cholesterol diet. Activities of plasma LPL and HL were determined; other data including concentration of plasma lipoprotein cholesterol, concentration of bile cholesterol and bile acids were also obtained. The results showed that with the rabbits continuously fed on high cholesterol diet, LPL activity heightened markedly (P < 0.05), and HL activity increased gradually (3 and 4 weeks groups vs control group, P < 0.05). The changes of concentration of plasma VLDL-C and LDL-C were the same as that of LPL activity, but the concentration of plasma HDL-C, HDL2-C, HDL3-C and bile acids showed no significant changes (P > 0.05). These results suggest that the heightened activities of LPL and HL might make the liver take up more cholesterol, secrete it into the bile duct and hence accelerate gallstone formation.
Shu
Y
Y
Department of Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041.
Cheng
Z
Z
Zhao
J
J
Zhou
Z
Z
Xiao
L
L
Cheng
N
N
Wu
H
H
D000818:Animals; D002769:Cholelithiasis / Q000201:enzymology*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D005260:Female; D008049:Lipase / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D011817:Rabbits; D011897:Random Allocation
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008049:Lipase; D008071:Lipoprotein Lipase