Philadelphia chromosome-positive chronic myeloid leukemia expressing p190(BCR-ABL).
We describe a case of Philadelphia chromosome-positive chronic myeloid leukemia (Ph-positive CML) expressing p190(BCR-ABL). Reverse transcription-polymerase chain reaction (RT-PCR) analysis of bone marrow cells showed a 472-bp band using primers specific for the p190(BCR-ABL) but not p210(BCR-ABL) transcript. Sequencing analysis revealed that the PCR product was derived from the fusion between BCR exon e1 and ABL exon a2 (e1a2). CML expressing p190(BCR-ABL) is relatively rare. In a review of the literature, it may be grouped into 2 categories; approximately half of the patients exhibited prominent monocytosis and intermediate hematological phenotype between CML and chronic myelomonocytic leukemia, and the remaining patients showed no monocytosis.
Ohsaka
Akimichi
A
Department of Transfusion Medicine, Juntendo University School of Medicine, Tokyo.
Shiina
Shigeo
S
Kobayashi
Masaru
M
Kudo
Hideyuki
H
Kawaguchi
Ryuji
R
D000230:Adenocarcinoma / Q000556:secondary; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000556:secondary
D016044:Fusion Proteins, bcr-abl