title: ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information.
abstract: We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins.
  
  
  BACKGROUND
  The ConSurf web server is available at:http://consurf.tau.ac.il.
  
  
  BACKGROUND
  A set of examples is available at http://consurf.tau.ac.il under 'GALLERY'.
authors.affiliation: The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel. fabian@ashtoret.tau.ac.il
authors.forename: Fabian
authors.initials: F
authors.lastname: Glaser
authors.forename: Tal
authors.initials: T
authors.lastname: Pupko
authors.forename: Inbal
authors.initials: I
authors.lastname: Paz
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Bell
authors.forename: Dalit
authors.initials: D
authors.lastname: Bechor-Shental
authors.forename: Eric
authors.initials: E
authors.lastname: Martz
authors.forename: Nir
authors.initials: N
authors.lastname: Ben-Tal
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics*; D030562:Databases, Protein; D019143:Evolution, Molecular; D020407:Internet; D010802:Phylogeny; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D014584:User-Computer Interface; D051020:bcl-X Protein
chemical_list: D000596:Amino Acids; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051020:bcl-X Protein