[The expression of cell adhesion molecules on lymphatic endothelial cells in rectum adenocarcinoma of human].
This study was conducted to explore the mechanism of lymphatic dissemination and metastasis of cancer cells; the specific aim was to investigate the expression of cells adhesion molecules on lymphatic endothelial cells. Immunohistochemical method was used. The rectum tissues and lymphnodes were taken from five normal human subjects. The cancer peripheral tissues and lymphnodes, and the metastasized lymphnodes were taken from eight patients with rectum adenocarcinoma. The result showed that the intercellular adhesion molecule-1 (ICAM-1) and carcinoma embryonic antigen (CEA) were expressed on lymphatic endothelial cells in cancer peripheral tissues and metastasized lymphnode. The expression of ICAM-1 and CEA in cancer peripheral tissues and lymphnodes was much more remarkable than that in metastasized lymphnodes. These data suggest that ICAM-1 and CEA be cell adhesion molecules between cancer cells and lymphatic endothelial cells.
Chen
Y
Y
Department of Anatomy, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Liu
Z
Z
Li
R
R
Jin
S
S
Li
C
C
D000230:Adenocarcinoma / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis; D004729:Endothelium, Lymphatic / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis*; D012004:Rectal Neoplasms / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1