title: Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains.
abstract: To characterize the ability of bifidobacteria to affect the production of macrophage-derived cytokines, a murine macrophage-like cell line, J774.1, was cultured in the presence of 27 strains of heat-inactivated bifidobacteria. Bifidobacterium adolescentis and B. longum, known as adult-type bifidobacteria, induced significantly more pro-inflammatory cytokine secretion, IL-12 and TNF-alpha, by J774.1 cells, than did the infant-type bifidobacteria, B. bifidum, B. breve, and B. infantis (P<0.01). In contrast, B. adolescentis did not stimulate the production of anti-inflammatory IL-10 from J774.1 cells as the other tested bacteria did. The results suggest that the adult-type bifidobacteria, especially B. adolescentis, may be more potent to amplify but less able to down-regulate the inflammatory response.
authors.affiliation: Technical Research Laboratory; Takanashi Milk Products Co., Ltd., Yokohama, Kanagawa 241-0023, Japan. he-fang@takanashi-milk.co.jp
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Morita
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Ouwehand
authors.forename: Masataka
authors.initials: M
authors.lastname: Hosoda
authors.forename: Masaru
authors.initials: M
authors.lastname: Hiramatsu
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kurisaki
authors.forename: Erika
authors.initials: E
authors.lastname: Isolauri
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Benno
authors.forename: Seppo
authors.initials: S
authors.lastname: Salminen
mesh_terms: D000328:Adult; D000818:Animals; D001644:Bifidobacterium / Q000276:immunology*; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D013045:Species Specificity
chemical_list: D016207:Cytokines