title: [Bone regeneration in oral surgery].
abstract: Bone regeneration is the technique of choice in order to repair small and medium sized bone defects in maxillary. It is used as an auxiliary medical treatment for dental implants. In this work, we show the different state of the art techniques used in bone lesions repair, and we also show experimental results obtained in our research group using bone morphogenetic protein BMP-2. This protein has been expressed in an E. Coli strain previously modified with the protein nucleotide sequence. We also show a carrier developed in our laboratory that is able to bind the rhBMP-2 and to liberate it in its active form. The mechanical properties of the carrier can be chemically modified. We have tested Ti implants covered with films of this material activated with rhBMP-2. The experimental in vivo results obtained with this kind of implants has been impressive.
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Sanz Casado
mesh_terms: D030201:Activin Receptors, Type I / Q000235:genetics / Q000494:pharmacology; D001777:Blood Coagulation / Q000235:genetics; D018586:Bone Banks / Q000639:trends; D052005:Bone Morphogenetic Protein Receptors, Type I; D001861:Bone Regeneration / Q000187:drug effects / Q000235:genetics*; D016723:Bone Remodeling / Q000235:genetics; D016025:Bone Transplantation / Q000639:trends; D002352:Carrier Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D015921:Dental Implants / Q000639:trends; D017886:Durapatite / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D017346:Protein Serine-Threonine Kinases; D017978:Receptors, Growth Factor; D013030:Spain; D013515:Surgery, Oral / Q000379:methods*; D014025:Titanium / Q000627:therapeutic use; D014182:Transplantation, Autologous / Q000639:trends
chemical_list: D002352:Carrier Proteins; D015921:Dental Implants; D017978:Receptors, Growth Factor; D017886:Durapatite; D014025:Titanium; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D052005:Bone Morphogenetic Protein Receptors, Type I