[Delayed effects of protein deficiency in nutrition of the pregnant rats on development of the enzymatic system in digestive and nondigestive organs of offspring].
It has been found for the first time that protein deficit in female's nutrition during prenatal development of the offspring is accompanied by considerable changes in the activity of intestinal digestive enzymes and of the same hydrolases in the colon, liver and kidneys both in early and in late ontogenesis. It seems possible that changes of the small intestine enzyme functions and hydrolytic functions of other digestive and non-digestive organs in result of an unfavorable early "metabolic/nutritional programming" may be crucial in disorders of metabolic processes leading to development of diseases of risk in adult life.
Timofeeva
N M
NM
I. P. Pavlov Institute of Physiology of the Russian Acade. Sci., St. Petersburg, 199034, Nab. Makarova, 6, Russia.
Gordova
L A
LA
Egorova
V V
VV
Nikitina
A A
AA
Iezuitova
N N
NN
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007422:Intestines / Q000201:enzymology* / Q000254:growth & development; D007668:Kidney / Q000201:enzymology* / Q000254:growth & development; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D011247:Pregnancy; D011248:Pregnancy Complications; D011488:Protein Deficiency / Q000150:complications*; D051381:Rats