Dopaminergic effects after chronic treatment with nandrolone visualized in rat brain by positron emission tomography.
Anabolic-androgenic steroids (AAS) have recently been shown to induce neurochemical alterations in areas of the male rat CNS related to behavioural changes that have been observed among AAS misusers. In the present study, positron emission tomography (PET) is suggested as a suitable in vivo method in order to visualize the density of the dopamine transporter ([11C]-FE-beta-CIT) as well as the dopamine D1-like ([11C]-(+)-SCH23390) and the D2-like receptors ([11C]-raclopride) in the male rat brain. Chronic treatment with the AAS nandrolone decanoate (15 mg/kg/day for 14 days) caused an up-regulation of the binding potential of the dopamine transporter in the striatum.
Kindlundh
Anna M S
AM
Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Box 591, S-751-24 Uppsala, Sweden. Anna.Kindlundh@farmbio.uu.se
Bergström
Mats
M
Monazzam
Azita
A
Hallberg
Mathias
M
Blomqvist
Gunnar
G
Långström
Bengt
B
Nyberg
Fred
F
D045930:Anabolic Agents / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D050483:Dopamine Plasma Membrane Transport Proteins; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000187:drug effects*; D009277:Nandrolone / Q000009:adverse effects* / Q000494:pharmacology; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology; D014055:Tomography, Emission-Computed; D015854:Up-Regulation
D045930:Anabolic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D009277:Nandrolone