title: Cloning and characterization of a novel splice variant of the brain-specific protein densin-180.
abstract: Densin-180 is a brain-specific synaptic protein of the o-sialoglycoprotein family. It functions in specific adhesion between presynaptic and postsynaptic membranes at glutamatergic synapses. We have cloned a novel splice variant of densin-180 from a fetal brain cDNA library and termed it LRRC7. It is located on 1p31 and consists of 8 exons. It encodes a putative protein of 216 amino acids which contains a nuclear localization signal and four leucine-rich repeats (LRRs). LRRs are 20-29 residue sequence motifs present in a number of proteins with diverse functions. Expression analysis of LRRC7 shows it is expressed ubiquitously while its splice variant densin-180 is brain-specific.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Liu
authors.initials: L
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Qihan
authors.initials: Q
authors.lastname: Wu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Dai
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Chaoneng
authors.initials: C
authors.lastname: Ji
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gu
authors.forename: Robert Chunhua
authors.initials: RC
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Yumin
authors.initials: Y
authors.lastname: Mao
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D012795:Sialoglycoproteins / Q000235:genetics*
chemical_list: C504461:LRRC7 protein, human; D012795:Sialoglycoproteins