Y chromosome genes and male infertility.
Normal spermatogenesis is a complex process that depends on many factors. Genetics plays a major role in many of these factors including providing a normal hormonal milieu, the development of the testis and ductal system, and control of the stepwise maturation of sperm in the testis. The Y chromosome plays a key role in testis determination and control of spermatogenesis. Understanding how these genes work together can elucidate of the exact cause of infertility in some patients once thought to have idiopathic infertility. It is not only important that patients understand the cause of their infertility. Using sperm from these men to attain pregnancies by assisted reproductive techniques will probably result in infertile male offspring. Additional consequences are currently unknown but are the topic of research investigations.
Pagani
Rodrigo
R
Division of Male Reproductive Medicine and Surgery, Scott Department of Urology, Baylor College of Medicine, 6560 Fannin Suite 2100, Houston, Texas 77030, USA.
Brugh
Victor M
VM
Lamb
Dolores J
DJ
D041322:Chromosomes, Human, Y / Q000235:genetics*; D056426:Genetic Loci; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D029589:Seminal Plasma Proteins / Q000235:genetics
D029589:Seminal Plasma Proteins