[Effect of Ebola virus antigen on proliferative response of human lymphocytes in vitro: imbalance in production of tumor necrosis factor alpha and interleukin-1].
An in vitro model infection caused by Ebola virus (EV) showed a high production of tumor necrosis factor-alpha by human peripheral lymphocytes concurrently with a simultaneous reduction in the synthesis of interleukin-1 in response EV antigen stimulation. This may be an important factor in that VE suppresses the body's immunological resistance, which in turn causes unterferon deficiency and suppresses the formation of T helper cells.
Tuzova
M N
MN
Sukhenko
T G
TG
Chepurnov
A A
AA
D000956:Antigens, Viral / Q000276:immunology*; D002455:Cell Division / Q000276:immunology*; D029043:Ebolavirus / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000956:Antigens, Viral; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha