[Effect of haidonghua powder(HDHP) on hypothalamic obesity in rats].
OBJECTIVE
To study the effect of HDHP including Laminaria japonica Aresch. and Benincasa hispida(Thunb.) Cogn. etc. on antiobesity in rats with hypothalamic obesity.


METHODS
A rat model of hypothalamic obesity induced by MSG was used and the relative indexes was observed.


RESULTS
HDHP(2.5 g.kg-1) could significantly reduce the Lee's index as well as the size of fat cells. HDHP did not influence the serum levels of T3 and T4, insulin and aldosterone, did not inhibited appetite not led to diarrhea.


CONCLUSIONS
HDHP has the effect of anti-obesity, Without any influencing on the function of thyroid gland and metabolism of water and salt. The mechanism is related to the reduction of fat cell size and the accumulation of fat.
Wang
W
W
Department of Geriatrics, Xiyuan Hospital, China Academy of TCM, Beijng 100091, China.
Wang
W X
WX
Sun
B H
BH
Zhao
D Z
DZ
Gao
P
P
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D015992:Body Mass Index; D019662:Cucurbitaceae / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007027:Hypothalamic Diseases / Q000150:complications*; D007795:Laminaria / Q000737:chemistry; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D019440:Anti-Obesity Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders