Genomic variability among enteric pathogens: the case of the mutS-rpoS intergenic region.
The mutS-rpoS intergenic region of enteric bacteria ranges in size from 88 bp in Yersinia to > 12000 bp in Salmonella. We interpret this expansion as the result of the horizontal transfer of segments of DNA from diverse origins. Both comparative genomic analysis and selective sequencing of a variety of Escherichia coli pathogens have provided additional evidence for reassortment of segments within this region.
Kotewicz
Michael L
ML
Division of Molecular Biology, Center for Food Safety & Applied Nutrition, US Food and Drug Administration, MOD-1, 8301 Muirkirk Road, Laurel, MD 20708, USA.
Brown
Eric W
EW
Eugene LeClerc
J
J
Cebula
Thomas A
TA
D000251:Adenosine Triphosphatases / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D021901:DNA, Intergenic / Q000235:genetics*; D004268:DNA-Binding Proteins; D004755:Enterobacteriaceae / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D029968:Escherichia coli Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D008957:Models, Genetic; D051719:MutS DNA Mismatch-Binding Protein; D009154:Mutation; D016366:Open Reading Frames; D010802:Phylogeny; D012641:Selection, Genetic; D012808:Sigma Factor / Q000235:genetics*
D001426:Bacterial Proteins; D021901:DNA, Intergenic; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein; C497175:MutS protein, E coli