Thalidomide-induced neuropathy.
BACKGROUND
Thalidomide is effective for the treatment of some refractory dermatologic and oncologic diseases. Toxic neuropathy limits its use, as embryopathy can be avoided by contraceptive measures.


OBJECTIVE
To describe the clinical, electrophysiologic, and pathologic features of thalidomide-induced peripheral neuropathy.


METHODS
Clinical and electrophysiologic examinations were performed in seven patients with thalidomide-induced peripheral neuropathy. Thalidomide was used for graft-vs-host disease, pyoderma gangrenosum, and discoid lupus with dosages ranging from 100 to 1,200 mg/day for 5 to 16 months (cumulative dosages of 24 to 384 g).


RESULTS
All seven patients had clinical and electrophysiologic evidence of a sensory more than motor, axonal, length-dependent polyneuropathy that presented as painful paresthesias or numbness. Sural nerve biopsies, done in three patients, showed evidence of Wallerian degeneration and loss of myelinated fibers. The symptoms, signs, and electrophysiologic data correlated with total cumulative dose of thalidomide.


CONCLUSIONS
Thalidomide induces a dose-dependent sensorimotor length-dependent axonal neuropathy; it should be judiciously used with close neurologic monitoring.
Chaudhry
V
V
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. vchaudh@jhmi.edu
Cornblath
D R
DR
Corse
A
A
Freimer
M
M
Simmons-O'Brien
E
E
Vogelsang
G
G
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000473:pathology* / Q000503:physiopathology; D010292:Paresthesia / Q000139:chemically induced; D012678:Sensation Disorders / Q000139:chemically induced / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology; D013792:Thalidomide / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D013792:Thalidomide