title: Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages.
abstract: We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.
authors.affiliation: Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Nakano
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Kishi
authors.forename: Norio
authors.initials: N
authors.lastname: Hirata
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Masaru
authors.initials: M
authors.lastname: Nasu
mesh_terms: D000818:Animals; D002981:Clindamycin / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D002981:Clindamycin