title: Virus-driven evolution of natural killer cell receptors.
abstract: Natural killer (NK) cells can mount an immediate response against viral infection, secreting cytokines and killing virus-infected cells. However, viruses have devised strategies to avoid immune detection. Here, we discuss NK cell recognition of viruses and propose that viruses may provide the evolutionary pressure causing the diversification of the NK cell receptors.
authors.affiliation: Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-0414, USA.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Arase
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000378:metabolism; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism*; D037181:Lectins, C-Type; D011971:Receptors, Immunologic / Q000378:metabolism; D055630:Receptors, NK Cell Lectin-Like; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*
chemical_list: D000950:Antigens, Ly; D037181:Lectins, C-Type; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like