Hold tight (but not too tight) to get it right: accurate bypass of an 8-oxoguanine lesion by DNA polymerase beta.
Crystal structures of DNA polymerase beta encountering an 8-oxoguanine lesion show how the polymerase selects an otherwise unfavorable conformation of a damaged template base to enable error-free bypass.
Brieba
Luis G
LG
Ellenberger
Tom
T
D000818:Animals; D004249:DNA Damage; D019951:DNA Polymerase beta / Q000737:chemistry* / Q000378:metabolism; D004261:DNA Replication; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011485:Protein Binding
C024829:8-hydroxyguanine; D006147:Guanine; D019951:DNA Polymerase beta