title: Diversity of the human erythrocyte membrane sialic acids in relation with blood groups.
abstract: The composition of the human erythrocyte membrane (RBC) glycoprotein- and glycolipid-bound sialic acids of A, B, AB and O type donors was studied using a new method (Zanetta et al., Glycobiology 11 (2001) 663-676). In addition to Neu5Ac as the major compound, Kdn, Neu5,9Ac(2), Neu5,7Ac(2), Neu (de-N-acetylated-Neu5Ac), Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac(2), Neu5,8Ac(2)9Lt and Neu5Ac8S were characterised. Among these different compounds, Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac(2), Neu5,8Ac(2)9Lt and Neu5Ac8S have never been described and quantitatively determined before in human tissues or cells. Neu5Gc and its O-alkylated or O-acylated derivatives were not detected.
authors.affiliation: Laboratoire de Glycobiologie Structurale et Fonctionnelle, CNRS Unité Mixte de Recherche No. 8576, Université des Sciences et Technologies de Lille, Bâtiment C9, 59655 Cedex, Villeneuve d'Ascq, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bulai
authors.forename: Daniela
authors.initials: D
authors.lastname: Bratosin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Pons
authors.forename: Jean
authors.initials: J
authors.lastname: Montreuil
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Zanetta
mesh_terms: D000017:ABO Blood-Group System / Q000737:chemistry*; D004912:Erythrocytes / Q000737:chemistry / Q000502:physiology*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D019158:N-Acetylneuraminic Acid / Q000032:analysis / Q000097:blood*; D013400:Sugar Acids / Q000032:analysis / Q000097:blood
chemical_list: D000017:ABO Blood-Group System; D013400:Sugar Acids; C050008:3-deoxyglycero-galacto-nonulosonic acid; D019158:N-Acetylneuraminic Acid