Brain natriuretic peptide and HIV-related cardiomyopathy.
The brain natriuretic peptide (BNP) assay is a new, relatively inexpensive, and simple test that has the potential to be an early, cost-effective, and reliable marker for HIV-related cardiomyopathy. We report 1 case of HIV-related cardiomyopathy and 10 cases of of HIV infection with unknown heart disease in which we measured BNP levels and performed echocardiography. We found a significant inverse relationship between BNP and left ventricular function in these patients. Further basic and epidemiologic research on BNP measurement for the detection of HIV-related cardiomyopathy is needed to support these findings, which if confirmed, could have important clinical and public health implications.
Carrillo-Jimenez
Rodolfo
R
Division of Cardiology, Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA.
Treadwell
Thomas L
TL
Goldfine
Harvey
H
Buenano
Alvaro
A
Lamas
Gervasio A
GA
Hennekens
Charles H
CH
D000328:Adult; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain