[Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion].
OBJECTIVE
To research the mechanism of protective action of TMCZKL on brain,


METHODS
Contents of transmitter amino acids in cortex and hippocampus before and after administration of TMCZKL were measured in mice of repetitious cerebral ischemia reperfusion.


RESULTS
The three doses of TMCZKL raised the content of glutamic acid in cortex and hippocampus the content of aspartic acid in hippocampus and decreased GABA content in cortex significantly.


CONCLUSIONS
TMCZKL might antagonize ischemic injury through regulating contents of transmitter amino acids and sustain the dynamic equilibrium of EAA and IAA.
Fu
J H
JH
Xiyuan Hospital, China Academy of TCM, Beijing 100092, China.
Du
G Y
GY
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications; D002540:Cerebral Cortex / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D029595:Orchidaceae; D010946:Plants, Medicinal; D011897:Random Allocation; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D019666:Rubiaceae; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid