A supercritical fluid-based coating technology. 2: solubility considerations.
Solubility measurements of candidate coating materials have been performed in supercritical (SC) CO(2) so as to select appropriate coating materials for implementation of a solvent-free coating process previously described. Solubility of lipidic compounds such as waxes (paraffin, beeswax, Carnauba wax), pure triglycerides (tricaprin, trimyristin, tripalmitin, tristearin) and mixture of glycerides and fatty acid esters (Gelucire) in SC CO(2) were evaluated in a static mode under different temperature and pressure conditions, ranging from 13-52 degrees C and from 50-220 bar, whether the CO(2)was in its liquid or SC state. It was shown that the compounds which are mixtures of various components give rise to a selective extraction of the lower melting point components, as evidenced from thermal analysis of soluble and insoluble fractions of the coating materials.
Ribeiro Dos Santos
I
I
Unité de Vectorisation Particulaire INSERM - ERIT M 0104, 10 rue A Boquel, 49100 Angers, France.
Thies
C
C
Richard
J
J
Le Meurlay
D
D
Gajan
V
V
VandeVelde
V
V
Benoit
J-P
JP
D002214:Capsules / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D008055:Lipids / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical; D013696:Temperature; D014885:Waxes / Q000737:chemistry
D002214:Capsules; D008055:Lipids; D014885:Waxes; D002245:Carbon Dioxide