[Expression and significance of p53 and proliferating cell nuclear antigen in malignant tumor of maxillary sinus].
OBJECTIVE
p53 and proliferating cell nuclear antigen (PCNA) play an important role in the development of malignant tumor. This study was designed to evaluate the role of p53 and PCNA in the development of malignant tumor of maxillary sinus by detecting their expression in malignant, benign, and inflammatory lesions of maxillary sinus.


METHODS
The expressions of p53 and PCNA were detected by immunohistochemistry in 108 malignant, 19 benign, and 8 inflammatory tissues of maxillary sinus. Rank sum test was used and the levels of positive degree of p53 and PCNA were represented by mean rank.


RESULTS
The mean ranks of p53 and PCNA were 42.8 and 47.9 in inflammatory group and 50.3 and 46.8 in benign group, but 73.0 and 73.2 in malignant group, respectively. In malignant group, mean rank of p53 in squamous cell carcinoma (SCC) was 60.7, which was higher than that in adenocarcinoma (43.9). The differences were significant (P < 0.05). While from stage I to stage IV, the mean ranks of p53 were 46.6, 50.1, 56.1, and 55.0 and the mean ranks of PCNA were 60.5, 48.8, 56.1, and.
Xie
Ru-hua
RH
Department of Combined Treatment, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China.
Chen
Zhi-hua
ZH
Chen
Ming-yuan
MY
Hou
Jin-hui
JH
Wu
Jian-hui
JH
Wu
Guo-hao
GH
Wu
Qiu-liang
QL
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D018322:Angiofibroma / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D009455:Neurofibroma / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012220:Rhinitis / Q000378:metabolism / Q000473:pathology; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53