Angiotensin-(1-7): an active member of the renin-angiotensin system.
Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross-talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).
Kucharewicz
I
I
Department of Pharmacodynamics, Medical Academy in Bialystok Mickiewicza 2c, 15-230 Bialystok, Poland.
Pawlak
R
R
Matys
T
T
Chabielska
E
E
Buczko
W
W
D000803:Angiotensin I / Q000502:physiology*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002455:Cell Division / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D010446:Peptide Fragments / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D013927:Thrombosis / Q000517:prevention & control
D010446:Peptide Fragments; D011945:Receptors, Angiotensin; D000803:Angiotensin I; C118790:angiotensin I (1-7)