Novel drug delivery device using silicone: controlled release of insoluble drugs or two kinds of water-soluble drugs.
Drug release mechanism from silicone carrier differs depending on physicochemical properties of the drug. So far, there have been few reports on controlled release of insoluble drug and on simultaneous release of two kinds of water-soluble drugs. The purposes of this study are to establish methods for (1). continuous release of insoluble drug, and (2). release of two kinds of water-soluble drugs from silicone carrier. Polystyrene beads (PSTB) and proteins such as interferon (IFN) and human serum albumin (HSA) were used as model drugs. PSTB was released from silicone only when citric acid (CA) and sodium bicarbonate (SB) existed as additives. The release patterns of IFN and HSA were almost same in the case of matrix and covered-rod formulations, but double-layered formulation released them in different patterns. As far as we are aware, this is the first report on the release of insoluble drug from silicone and the controlled release of two kinds of water-soluble drugs.
Kajihara
Masako
M
Research Division, Sumitomo Pharmaceuticals Co, Ltd, Osaka, Japan. kajihara@sumitomopharm.co.jp
Sugie
Toshihiko
T
Maeda
Hiroo
H
Sano
Akihiko
A
Fujioka
Keiji
K
Urabe
Yosuke
Y
Tanihara
Masao
M
Imanishi
Yukio
Y
D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D012828:Silicones / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012995:Solubility
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012828:Silicones