[Studies on the inhibitory effects of tea polyphenols and tea pigments on liver precancerous lesion in rats].
The chemopreventive effects of tea polyphenols and tea pigments on liver precancerous lesion in rats were investigated. The results showed that the density and area of GST-P in the tea-treated groups were significantly reduced as compared with the positive control group. Furthermore, tea polyphenols and tea pigments induced the expression of p21WAF1 protein, inhibited the expression of Bcl-2 protein and induced the expression of Bax protein. It is concluded that GST-P was significantly inhibited by tea polyphenols and tea pigments and inhibition of cell proliferation and induction of apoptosis may be the two important mechanisms.
Jia
X
X
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Han
C
C
Chen
J
J
D000818:Animals; D000831:Animals, Newborn; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D005419:Flavonoids; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D015689:Oncogene Protein p21(ras) / Q000096:biosynthesis / Q000235:genetics; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010860:Pigments, Biological / Q000302:isolation & purification / Q000494:pharmacology; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D011230:Precancerous Conditions / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D010860:Pigments, Biological; D011108:Polymers; D059808:Polyphenols; D019253:Proto-Oncogene Proteins c-bcl-2; D013662:Tea; D015689:Oncogene Protein p21(ras)