title: [Clinicopathological study of primary meningeal hemangiopericytoma].
abstract: OBJECTIVE
  Meningeal hemangiopericytoma is an uncommon tumor. This study was designed to investigate the clinicopathological and biology behavior of primary meningeal hemangiopericytoma.
  
  
  METHODS
  Clinical data, combined with histopathology and immunohistochemistry of 20 cases of meningeal hemangiopericytoma were reviewed, in which 4 specimens were examined with electron microscope.
  
  
  RESULTS
  The average age of patients with primary meningeal hemangiopericytoma was 42.4 year-old (21-69 years). The ratio of male to female was 1.2: 1. Most of the patients went to hospital for the symptoms of central nervous system such as headache. The tumor could occur on any locus of the cranial or spinal dura. Grossly, many of the tumors had capsule, whose testure were tenacious, and part of them looks like fish meat. Histopathologically, the small vascular spaces in the tumor were rich, the typical antler-liked vessel could be found, the short-spindle tumor cells were around the vessel, and distributed by radiation-shape. The tumor cells were pleomorphic and atypical, and could be found mitotic activity. Staining of argyrophilic fiber: the argyrophilic fiber surrounded single tumor cell, and distributed by radiation-shape around vessel. Immunohistochemistry showed negative for S-100 protein, F VIII, EMA, GFAP and CD34, while Vim was positive. Electron microscopically, the rich bundles of 10nm long intermediate filaments could be found in tumor cells. The exobasallamina, of cells were evidenced, and distributed around single cell. Follow-up, 8 of 17 cases were relapsed (47.1%).
  
  
  CONCLUSIONS
  Meningeal hemangiopericytoma is a low-malignant tumor original from meningeal mesenchymal tissue. The features of histopathology, immunphenotype and ultrastructure are similar to hemangiopericytoma of the soft tissue.
authors.affiliation: Department of Pathology, Nanjing Military General Hospital of PLA, School of Clinical Medicine, Nanjing University, Jiangsu, Nanjing, 210002, P. R. China. shizhaoyui@sina.com.cn
authors.forename: Qun-li
authors.initials: QL
authors.lastname: Shi
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Zhen-feng
authors.initials: ZF
authors.lastname: Lu
authors.forename: Kui
authors.initials: K
authors.lastname: Meng
authors.forename: Xing-zao
authors.initials: XZ
authors.lastname: Jin
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Yan
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Chun-ning
authors.initials: CN
authors.lastname: Sheng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006393:Hemangiopericytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin