title: Analysis of the gene encoding copper/zinc superoxide dismutase homolog in Dictyostelium discoideum.
abstract: SodD, a Cu/Zn superoxide dismutase in Dictyostelium discoideum, shows 48% identity to the cytosolic Cu/Zn superoxide dismutase (SOD) of Saccharomyces cerevisiae (SOD1). The sodD gene is expressed in D. discoideum cells at late-developmental stages. However, gene expression was not detected in the sporeless mutant, indicating that sodD is a spore cell-specific gene. The D. discoideum mutant, in which sodD was disrupted, grew and formed a multicellular structure normally, therefore the gene is not essential for growth and development. The mutant spores were sensitive to UV-light compared to the wild-type spores, indicating that SodD protects spores from cellular damage caused by UV-light.
authors.affiliation: Division of Bioengineering, Faculty of Engineering, Toyama University, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Akaza
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsuji
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yasukawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004023:Dictyostelium / Q000201:enzymology* / Q000235:genetics* / Q000528:radiation effects; D005796:Genes / Q000528:radiation effects; D008969:Molecular Sequence Data; D009154:Mutation; D015800:Protozoan Proteins / Q000235:genetics* / Q000528:radiation effects; D017422:Sequence Analysis, DNA / Q000379:methods; D017386:Sequence Homology, Amino Acid; D013482:Superoxide Dismutase / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D015800:Protozoan Proteins; D013482:Superoxide Dismutase