[The relations of cellular DNA content to lymph node metastasis in gastric carcinoma].
The objectives of this study were to evaluate the relations of cellular DNA content, S-phase fraction (SPF) and G2/M-phase(G2/MPF) to lymph node metastasis in gastric carcinoma by using flow cytometry. The results showed that the incidence of lymph node metastasis and SPF were significantly higher in aneuploid carcinoma than in diploid carcinoma(P < 0.05). But the G2/MPF values did not correlate with lymph node metastasis. These findings suggest that correlations between cellular DNA content, SPF and the extent of lymph node metastasis are present.
Chen
Z
Z
Department of Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041.
Wang
Y
Y
Hu
J
J
Chen
J
J
Yan
L
L
Lei
S
S
D000230:Adenocarcinoma / Q000235:genetics / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm