Chondromodulin I is a bone remodeling factor.
Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor.
Nakamichi
Yuko
Y
The Institute of Molecular and Cellular Biosciences. The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Shukunami
Chisa
C
Yamada
Takashi
T
Aihara
Ken-ichi
K
Kawano
Hirotaka
H
Sato
Takashi
T
Nishizaki
Yuriko
Y
Yamamoto
Yoko
Y
Shindo
Masayo
M
Yoshimura
Kimihiro
K
Nakamura
Takashi
T
Takahashi
Naoyuki
N
Kawaguchi
Hiroshi
H
Hiraki
Yuji
Y
Kato
Shigeaki
S
D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D015139:Blotting, Southern; D015153:Blotting, Western; D001846:Bone Development; D001854:Bone Marrow Cells / Q000378:metabolism; D002356:Cartilage / Q000196:embryology; D002478:Cells, Cultured; D005260:Female; D006720:Homozygote; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008957:Models, Genetic; D010006:Osteoblasts / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011995:Recombination, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction
C489408:Cnmd protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger