Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.
Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1; and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms.
Blackwell
Jenefer M
JM
Cambridge Institute for Medical Research, School of Clinical Medicine, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK. jmb37@cus.cam.ac.uk
Searle
Susan
S
Mohamed
Hiba
H
White
Jacqueline K
JK
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism; D027682:Cation Transport Proteins / Q000502:physiology*; D002413:Cations, Divalent / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D017136:Ion Transport; D007501:Iron / Q000378:metabolism*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011401:Promoter Regions, Genetic; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D002413:Cations, Divalent; D007501:Iron; D000099173:Natural Resistance-associated Macrophage Protein 1