title: Total coenzyme Q10 concentrations in Asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets.
abstract: Coenzyme Q(10) (CoQ(10)), a highly lipophilic compound present in the inner mitochondrial membrane, is essential for production of cellular energy in the form of ATP. CoQ(10) is used as a dietary supplement and for treatment of various cardiovascular disorders. Our goal was to compare the CoQ(10) levels in Asians following multiple oral doses administered as sustained release or regular tablets. Twenty healthy male volunteers (19-23 years old) were divided into two equal groups. Each subject in Group I received 50 mg oral doses of coenzyme Q(10) as sustained release tablets once a day for fifteen days, while subject in Group II received 50 mg doses of coenzyme Q(10) regular tablets. The CoQ(10) levels were measured by HPLC-UV (reverse phase ODS column, 10 microm, 250 x 4.6 mm; oven temperature 30 degrees C). Mobile phase was constituted by methanol-ethanol 9 : 1 v/v. Flow rate was 1.5 ml/min and UV detection was carried out at 275 nm. Coenzyme Q(9) was used as an internal standard. CoQ(10) baseline in the morning was 0.88+/-0.48 mg/l. Following 1 week 50 mg/d dosing of CoQ(10), plasma CoQ(10) concentrations increased to 1.85+/-1.03 mg/l for sustained release tablets and up to 1.37+/-0.74mg/l for regular tablets. The net increment proportion in AUC for sustained release and regular tablets were 148.26+/-176.56%, 102.57+/-130.00%, respectively. Both preparations significantly increased the systemic exposure when compared to endogenous baseline.
authors.affiliation: School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. phcluwl@nus.edu.sg
authors.forename: Wan-Liang
authors.initials: WL
authors.lastname: Lu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: How-Sung
authors.initials: HS
authors.lastname: Lee
authors.forename: Tian-Yan
authors.initials: TY
authors.lastname: Zhou
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Michael
authors.initials: M
authors.lastname: Lee
authors.forename: Sai-Ming
authors.initials: SM
authors.lastname: Wong
mesh_terms: D000328:Adult; D019540:Area Under Curve; D044466:Asian People / Q000235:genetics*; D003067:Coenzymes; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D013607:Tablets; D014451:Ubiquinone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D003067:Coenzymes; D003692:Delayed-Action Preparations; D013607:Tablets; D014451:Ubiquinone; C024989:coenzyme Q10