The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity.
Granzyme M (GM) is a novel serine protease whose expression is highly restricted to natural killer (NK) cells, CD3(+)CD56(+) T cells, and gamma delta T cells. Using a GM-specific monoclonal antibody, we analyzed the expression of GM in 214 mature T-cell and NK-cell lymphomas. GM was preferentially expressed in nasal NK/T-cell lymphomas (100%), gamma delta T-cell lymphomas (100%), and intestinal T-cell lymphomas (85%). In contrast, GM expression was present at low prevalence in mycosis fungoides/Sézary syndrome (3%), anaplastic large-cell lymphoma (6%), panniculitis-like T-cell lymphoma (11%), and angioimmunoblastic T-cell lymphoma (0%) cases. Peripheral T-cell lymphomas of unspecified subtype showed an intermediate frequency (37%) of GM expression, consistent with their heterogeneous origin. We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity.
Krenacs
Laszlo
L
Laboratory of Tumor Pathology and Molecular Diagnostics, Institute for Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary.
Smyth
Mark J
MJ
Bagdi
Eniko
E
Krenacs
Tibor
T
Kopper
Laszlo
L
Rudiger
Thomas
T
Zettl
Andreas
A
Muller-Hermelink
Hans Konrad
HK
Jaffe
Elaine S
ES
Raffeld
Mark
M
D019070:Cell Lineage; D053804:Granzymes; D006801:Humans; D007113:Immunity, Innate; D007414:Intestinal Neoplasms / Q000201:enzymology*; D007694:Killer Cells, Natural / Q000201:enzymology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology; D016399:Lymphoma, T-Cell / Q000201:enzymology*; D009182:Mycosis Fungoides / Q000201:enzymology; D009363:Neoplasm Proteins / Q000032:analysis*; D014411:Neoplastic Stem Cells / Q000201:enzymology; D009669:Nose Neoplasms / Q000201:enzymology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012697:Serine Endopeptidases / Q000032:analysis*; D012751:Sezary Syndrome / Q000201:enzymology
D009363:Neoplasm Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; C509218:GZMM protein, human; D053804:Granzymes; D012697:Serine Endopeptidases