[The regulatory role of the Hfq protein in bacterial cells].
Hfq (HF1) is a polyfunctional translational regulator of numerous bacterial mRNAs. Its physico-chemical properties, possible mechanisms regulating bacterial translation, and the effect of Hfq on transcription of several mRNAs are considered. A similarity of Hfq and eukaryotic mRNA splicing proteins is discussed. Data are reviewed on the roles of Hfq in poly(A) metabolism and formation of the bacterial nucleoid and on the Hfq interaction with untranslated regulatory RNAs.
Vasil'eva
Iu M
IuM
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia. yuvas@vega.protres.ru
Garber
M B
MB
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D035001:Host Factor 1 Protein / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011061:Poly A / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C087373:Hfq protein, E coli; D035001:Host Factor 1 Protein; D012333:RNA, Messenger; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D011061:Poly A