Non-preserved 1% lidocaine solution has less antibacterial properties than currently available anaesthetic eye-drops.
OBJECTIVE
Some anaesthetics inhibit bacterial growth, and thus may lead to low rates of positive cultures from bacterial keratitis. Antibacterial properties of lidocaine were compared with those of oxybuprocaine or tetracaine, either in current commercial eye lotions or in extemporaneous solutions.


METHODS
Forty-eight bacterial strains were used to determine the minimum inhibitory and bactericidal concentrations of four commercial eye lotions containing oxybuprocaine or tetracaine, of a non-ophthalmic 1% lidocaine commercial solution and of extemporaneously prepared solutions of oxybuprocaine, tetracaine, lidocaine and benzalkonium.


RESULTS
Most strains had their growth inhibited by 0.2% oxybuprocaine or 0.4% tetracaine, which corresponds to a 1/2 dilution of the commercial eye-drops. Bacterial growth was still observed with a 1% lidocaine solution.


CONCLUSIONS
Currently available anaesthetic eye-drops that are used before corneal specimen collection may lead to false-negative bacterial cultures. Conversely, a non-preserved 1% lidocaine solution might be more appropriate in corneal specimen collection.
Labetoulle
Marc
M
Department of Ophthalmology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Paris, France.
Frau
Eric
E
Offret
Hervé
H
Nordmann
Patrice
P
Naas
Thierry
T
D000779:Anesthetics, Local / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology; D011343:Procaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013748:Tetracaine / Q000494:pharmacology
D000779:Anesthetics, Local; D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D013748:Tetracaine; D011343:Procaine; D008012:Lidocaine; C005298:benoxinate