[Glia-like brain tumors. Potential role of thyroid hormone and its nuclear receptors (TR)].
Over-proliferation of certain cells lead to tumor formation and therefore impairments of regulation of the cell cycle are inalienable and basic signs of neoplasms. The majority of known oncogenes and tumor suppressors are components of a few common signaling pathways that control the cell cycle, genome integrity, cell differentiation and apoptosis. Changes in these signaling pathways cause the development of tumor genesis. The thyroid hormones (3, 5, 3'-L-triiodothyronine, T3; 3, 5, 3', 5'-L tetraiodothyronine, T4; TH) play crucial roles in the growth and differentiation of many organs, including the central nervous system. TH exerts its major effect by binding to the nuclear TH receptor (TR). TR is bound to specific DNA sequences known as TH-response elements (TREs), composed of two half-site core motifs (AGGTCA), with specific nucleotide spacing and orientation. TR also bind to several coregulators such as corepressors and coactivators. The liganded complexes ultimately determines nuclear TH action. .
Nauman
Paweł
P
Klinika Neurochirurgii, Instytut Centrum Medycyny Doświadczalnej i Klinicznej PAN w Warszawie. paulnauman@hotmail.com
Czernicki
Zbigniew
Z
D017209:Apoptosis; D001932:Brain Neoplasms / Q000378:metabolism*; D002454:Cell Differentiation; D005910:Glioma / Q000378:metabolism; D006801:Humans; D009457:Neuroglia / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D015398:Signal Transduction; D013963:Thyroid Hormones / Q000378:metabolism*
D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones