Central beta-adrenergic modulation of cognitive flexibility.
Situational stressors and anxiety impede performance on creativity tests requiring cognitive flexibility. Preliminary research revealed better performance on a task requiring cognitive flexibility, the anagram task, after propranolol (beta-adrenergic antagonist) than after ephedrine (beta-adrenergic agonist). However, propranolol and ephedrine have both peripheral and central beta-adrenergic effects. In order to determine whether noradrenergic modulation of cognitive flexibility is a centrally or peripherally mediated phenomenon, we compared the effects of propranolol (peripheral and central beta-blocker), nadolol (peripheral beta-blocker), and placebo on anagram task performance. Solution latency scores for each subject were compared across the drug conditions. Anagram solution latency scores after propranolol were significantly lower than after nadolol. This suggests a centrally mediated modulatory influence of the noradrenergic system on cognitive flexibility.
Beversdorf
David Q
DQ
Department of Psychiatry, University of Colorado Health Science Center, Denver, CO 80262, USA.
White
Dawn M
DM
Chever
Daquesha C
DC
Hughes
John D
JD
Bornstein
Robert A
RA
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004809:Ephedrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D009248:Nadolol / Q000008:administration & dosage; D009638:Norepinephrine / Q000502:physiology; D011340:Problem Solving / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D009248:Nadolol; D011433:Propranolol; D004809:Ephedrine; D009638:Norepinephrine