title: Collagen as an implantable material in medicine and dentistry.
abstract: Collagen is a highly versatile material, extensively used in the medical, dental, and pharmacological fields. Collagen is capable of being prepared into cross-linked compacted solids or into lattice-like gels. Resorbable forms of collagen have been used to dress oral wounds, for closure of graft and extraction sites, and to promote healing. Collagen-based membranes also have been used in periodontal and implant therapy as barriers to prevent epithelial migration and allow cells with regenerative capacity to repopulate the defect area. It has been hypothesized that membrane regenerative techniques facilitate the natural biological potential by creating a favorable environment for periodontal and peri-implant regeneration. Due to the enormous potential of collagen-based regenerative barriers, clinicians may benefit from a review of potential applications of implantable collagen and knowledge of collagen preparation and membrane types as well as from as awareness of the functional and degradation properties of those materials.
authors.affiliation: Department of Periodontics and Endodontics, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Patino
authors.forename: Mirdza E
authors.initials: ME
authors.lastname: Neiders
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Andreana
authors.forename: Bernice
authors.initials: B
authors.lastname: Noble
authors.forename: Robert E
authors.initials: RE
authors.lastname: Cohen
mesh_terms: D020341:Absorbable Implants; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D001673:Biodegradation, Environmental; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003758:Dental Implantation, Endosseous; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008567:Membranes, Artificial; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D008567:Membranes, Artificial; D003094:Collagen