Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation.
Results of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
Tse
Hung-Fat
HF
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China. hftse@hkucc.hku.hk
Kwong
Yok-Lam
YL
Chan
John K F
JK
Lo
Gladys
G
Ho
Chi-Lai
CL
Lau
Chu-Pak
CP
D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000628:therapy*; D018919:Neovascularization, Physiologic; D011446:Prospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome