title: Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains.
abstract: Pal and Cpl-1, two purified bacteriophage lytic enzymes, were tested for their in vitro activity, alone and in combination, against several serotypes of Streptococcus pneumoniae, including penicillin-resistant strains. The enzymes demonstrated synergism in their ability to cleave the bacterial peptidoglycan and thus may be more efficient for the prevention and elimination of pneumococcal colonization.
authors.affiliation: Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York, 10021, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Loeffler
authors.forename: V A
authors.initials: VA
authors.lastname: Fischetti
mesh_terms: D010403:Penicillin Resistance; D012703:Serotyping / Q000379:methods; D017108:Streptococcus Phages / Q000201:enzymology*; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects