title: EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenics.
abstract: Electroencephalographic (EEG) coherence is an index of brain regional coupling that has been found to be abnormal in people with schizophrenia but has not been systematically examined in response to neuroleptics. EEG coherence in slow (delta and theta) frequencies was assessed in 17 treatment-resistant people with schizophrenia at baseline, 2 hr after their first oral dose (25 mg) and after 6 weeks of clozapine treatment. Compared with EEG norms, participants exhibited significant interhemispheric and intrahemispheric coherence abnormalities prior to treatment. Both acute and chronic treatments altered coherence but differed with respect to their relationship to symptom reduction and their ability to normalize or augment pretreatment abnormalities. Findings are discussed in relation to "disconnection" theories of schizophrenia.
authors.affiliation: Department of Psychiatry and Psychology, University of Ottawa/Royal Ottawa Hospital, Ontario, Canada. vknott@rohcg.on.ca
authors.forename: Verner J
authors.initials: VJ
authors.lastname: Knott
authors.forename: Alain
authors.initials: A
authors.lastname: LaBelle
authors.forename: Barry
authors.initials: B
authors.lastname: Jones
authors.forename: Colleen
authors.initials: C
authors.lastname: Mahoney
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001931:Brain Mapping; D003024:Clozapine / Q000627:therapeutic use*; D003700:Delta Rhythm; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013826:Theta Rhythm; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine