Longstanding ataxic demyelinating polyneuronopathy with a novel autoantibody.
The authors describe the clinical course, postmortem findings, and characterization of a novel autoantibody (anti-M-phase phosphoprotein-1 [anti-MPP-1]) in a patient with a longstanding acquired demyelinating polyneuropathy and neuronopathy. Postmortem examination identified active sensory neuron degeneration, sensory axon loss, and widespread peripheral nerve demyelination. A possible pathophysiologic role of anti-MPP-1 is not yet identified.
Zochodne
Douglas W
DW
Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Alberta, Canada. dzochodn@ucalgary.ca
Auer
Roland
R
Fritzler
Marvin J
MJ
D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery; D000368:Aged; D001259:Ataxia / Q000209:etiology*; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D018797:Cell Cycle Proteins; D018450:Disease Progression; D004568:Electrodiagnosis; D017809:Fatal Outcome; D005727:Ganglia, Spinal / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D016547:Kinesins; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery; D008297:Male; D009431:Neural Conduction; D010750:Phosphoproteins / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D011233:Precipitin Tests; D011930:Reaction Time; D013116:Spinal Cord / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology
D001323:Autoantibodies; D018797:Cell Cycle Proteins; D016756:Immunoglobulins, Intravenous; D010750:Phosphoproteins; C438388:KIF20B protein, human; D016547:Kinesins