title: New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata.
abstract: Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
authors.affiliation: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan. yihduh@mail.nsysu.edu.tw
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Ali Ali H
authors.initials: AA
authors.lastname: El-Gamal
authors.forename: Chin-Ying
authors.initials: CY
authors.lastname: Chiang
authors.forename: Chih-Ju
authors.initials: CJ
authors.lastname: Chu
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003110:Colonic Neoplasms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D008175:Lung Neoplasms; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes