title: [Effect of L-dicentrine on contraction of rat stomach muscle strips].
abstract: OBJECTIVE
  To study the effect of L-dicentrine on the contraction of rat stomach muscle strips induced by 5-HT, histamine K+ and Ca2+.
  
  
  METHODS
  In-vitro experimenting on rat stomach muscle strips.
  
  
  RESULTS
  The contraction of the strips induced by 5-HT histamine K+ and Ca2+ after high K+ depolarization was markedly inhibited by L-dicentrine or papaverine, showing a non-competitive antagonism. The contraction induced by 5-HT was inhibited by L-dicentrine in Ca2+ free solution. L-Dicentrine inhibited the contraction induced by 5-HT, depending on Ca2+ released from the intracellular store. When the Ca2+ concentration in both solutions was restored, L-dicentrine did not influence the contraction significantly.
  
  
  CONCLUSIONS
  L-Dicentrine could relax the rat stomach smooth muscle. In rat stomach smooth muscles there exist 5-HT receptors.
authors.affiliation: Department of Pharmacology, Kunming Medical College, Kunming 650031, Yunnan, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Li
authors.forename: R P
authors.initials: RP
authors.lastname: Zhang
authors.forename: H T
authors.initials: HT
authors.lastname: Ye
authors.forename: H
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D029583:Menispermaceae / Q000737:chemistry; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects
chemical_list: D001060:Aporphines; C067342:dicentrine