Alternate stranded triplex formation of chimeric DNA composed of tandem alpha- and beta-anomeric strands.
A chimeric oligoDNA composed of a natural beta-anomeric oligonucleotide portion and an unnatural alpha-anomeric oligonucleotide portion forms an alternate stranded triplex possessing enhanced thermal stability compared to the triplexes composed of the parental oligomers.
Shinozuka
Kazuo
K
Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan. sinozuka@chem.gunma-u.ac-jp
Matsumoto
Noritake
N
Suzuki
Hideo
H
Moriguchi
Tomohisa
T
Sawai
Hiroaki
H
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation
C051802:triplex DNA; D004247:DNA