title: Synthesis and DNA strand breakage activity of some 1,4-diazepines.
abstract: Reactions of 1,3-propanediamine with alpha-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. mibu@fukuoka-u.ac.jp
authors.forename: Nobuko
authors.initials: N
authors.lastname: Mibu
authors.forename: Miho
authors.initials: M
authors.lastname: Yukawa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kashige
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Iwase
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Goto
authors.forename: Fumio
authors.initials: F
authors.lastname: Miake
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ito
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects* / Q000502:physiology
chemical_list: D001381:Azepines