title: Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
abstract: We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.
authors.affiliation: Service of Clinical Hematology, Hospital Geral de Santo António, Porto, Portugal. mmc.lima@clix.pt
authors.forename: Margarida
authors.initials: M
authors.lastname: Lima
authors.forename: Luísa
authors.initials: L
authors.lastname: Pinto
authors.forename: Maria
authors.initials: M
authors.lastname: Dos Anjos Teixeira
authors.forename: Aurea
authors.initials: A
authors.lastname: Canelhas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Mota
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Cabeda
authors.forename: Cidália
authors.initials: C
authors.lastname: Silva
authors.forename: Maria Luís
authors.initials: ML
authors.lastname: Queirós
authors.forename: Sónia
authors.initials: S
authors.lastname: Fonseca
authors.forename: Ana Helena
authors.initials: AH
authors.lastname: Santos
authors.forename: Paulo
authors.initials: P
authors.lastname: Brochado
authors.forename: Benvindo
authors.initials: B
authors.lastname: Justiça
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018956:CD5 Antigens / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D017455:Receptors, IgE / Q000032:analysis; D014178:Translocation, Genetic
chemical_list: D018956:CD5 Antigens; D017455:Receptors, IgE