title: Gastroprotective effects of a crude extract of Baccharis illinita DC in rats.
abstract: Baccharis illinita DC (Compositae) is used in folk medicine to treat gastric disorders. The crude hydroalcoholic extract of leaves and stems tested on mice at doses from 1.0 to 6.0 g/kg, PO, did not produce signs of toxicity. Only the aqueous extract of leaves (0.1 g/kg, PO) increased intestinal motility in mice. The crude hydroalcoholic extract of stems and leaves (HESL) protected rats against lesions induced by ethanol or restraint-in-cold. The crude aqueous extract of roots protected against ulcers induced by ethanol, indomethacin or restraint-in-cold, and the crude aqueous extract of flowers only protected against lesions induced by ethanol. When injected into the duodenal lumen, the aqueous root extract inhibited basal acid secretion in pylorus-ligated rats. The results obtained in the present pharmacological assays indicate that this plant has a protective action against gastric lesions of the mucosa involving the maintenance of protective factors such as mucus, bicarbonate and blood flow, besides the reduction of gastric acid secretion.
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Caixa Postal 19031, Centro Politécnico-Jardim das Américas, Curitiba-PR 81531-990, Brazil.
authors.forename: Cristiane Hatsuko
authors.initials: CH
authors.lastname: Baggio
authors.forename: Cristina Setim
authors.initials: CS
authors.lastname: Freitas
authors.forename: Lia
authors.initials: L
authors.lastname: Rieck
authors.forename: Maria Consuelo Andrade
authors.initials: MC
authors.lastname: Marques
mesh_terms: D000818:Animals; D031175:Baccharis; D035264:Flowers; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D018517:Plant Roots; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts