title: Advanced studies on the hypoglycemic effect of Caesalpinia bonducella F. in type 1 and 2 diabetes in Long Evans rats.
abstract: Caesalpinia bonducella, widely distributed throughout the coastal region of India and used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model. This prompted us to undertake a detail study with the aqueous and ethanolic extracts of the seeds of this plant in both type 1 and 2 diabetes mellitus in Long Evans rats. Significant blood sugar lowering effect (P < 0.05) of C. bonducella was observed in type 2 diabetic model. Special emphasis was given on the mechanistic study by gut absorption of glucose and liver glycogen.
authors.affiliation: SN Pradhan Centre for Neurosciences, University College of Medicine, Calcutta University, 244B Acharya JC Bose Road, Kolkata 700020, India.
authors.forename: Shrabana
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: Tuhin Kanti
authors.initials: TK
authors.lastname: Biswas
authors.forename: Begum
authors.initials: B
authors.lastname: Rokeya
authors.forename: Liaquat
authors.initials: L
authors.lastname: Ali
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: Nilufer
authors.initials: N
authors.lastname: Nahar
authors.forename: A K Azad
authors.initials: AK
authors.lastname: Khan
authors.forename: Biswapati
authors.initials: B
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D006003:Glycogen