title: Diffusion-weighted MRI after cryosurgery of the canine prostate. Magnetic resonance imaging.
abstract: OBJECTIVE
  To evaluate the acute lesion created by cryosurgery with diffusion-weighted magnetic resonance imaging (DWI).
  
  
  METHODS
  The appearance of the acute cryolesion was evaluated in four canine prostates DWI after they were warmed to original body temperature. The prostates were excised, stained with triphenyl tetrazolium chloride (TTC), photographed, prepared for hematoxylin and eosin (H&E) staining, and examined under a light microscope.
  
  
  RESULTS
  A marked decrease in apparent diffusion coefficient of 38% was evident in the center of the previously frozen tissue, but not in all of the previously frozen tissue. Histologic results confirm differences between the iceball core and the periphery of the iceball, which have markedly different imaging characteristics on DWI.
  
  
  CONCLUSIONS
  The core of the previously frozen tissue has a reduced apparent diffusion coefficient (ADC) compared to the periphery of the previously frozen tissue and previously unfrozen tissue.
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA. kim@lucas.stanford.edu
authors.forename: Kim
authors.initials: K
authors.lastname: Butts
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Daniel
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.forename: Donna M
authors.initials: DM
authors.lastname: Bouley
authors.forename: Janaka
authors.initials: J
authors.lastname: Wansapura
authors.forename: Stephan E
authors.initials: SE
authors.lastname: Maier
authors.forename: Charles
authors.initials: C
authors.lastname: Dumoulin
authors.forename: Ron
authors.initials: R
authors.lastname: Watkins
mesh_terms: D000818:Animals; D003452:Cryosurgery; D038524:Diffusion Magnetic Resonance Imaging; D004285:Dogs; D008297:Male; D011467:Prostate / Q000033:anatomy & histology*