title: [Bitemporal lobe dysfonction in infantile autism: positron emission tomography study].
abstract: OBJECTIVE
  Childhood autism is a severe developmental disorder that impairs the acquisition of some of the most important skills in human life. Progress in understanding the neural basis of childhood autism requires clear and reliable data indicating specific neuroanatomical or neurophysiological abnormalities. The purpose of the present study was to research localized brain dysfunction in autistic children using functional brain imaging.
  
  
  METHODS
  Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) in 21 primary autistic children and 10 age-matched non autistic children.
  
  
  RESULTS
  A statistical parametric analysis of rCBF images revealed significant bilateral temporal hypoperfusion in the associative auditory cortex (superior temporal gyrus) and in the multimodal cortex (superior temporal sulcus) in the autistic group (p<0.001). In addition, temporal hypoperfusion was detected individually in 77% of autistic children.
  
  
  CONCLUSIONS
  These findings provide robust evidence of well localized functional abnormalities in autistic children located in the superior temporal lobe. Such localized abnormalities were not detected with the low resolution PET camera,. This study suggests that high resolution PET camera combined with statistical parametric mapping is useful to understand developmental disorders.
authors.affiliation: Service Hospitalier Frédéric Joliot, ER-M INSERM 0205, DSV, DRM, CEA, Orsay, 4, place du Général Leclerc 91406, Orsay, France.
authors.forename: N
authors.initials: N
authors.lastname: Boddaert
authors.forename: N
authors.initials: N
authors.lastname: Chabane
authors.forename: C
authors.initials: C
authors.lastname: Barthélemy
authors.forename: M
authors.initials: M
authors.lastname: Bourgeois
authors.forename: J B
authors.initials: JB
authors.lastname: Poline
authors.forename: F
authors.initials: F
authors.lastname: Brunelle
authors.forename: Y
authors.initials: Y
authors.lastname: Samson
authors.forename: M
authors.initials: M
authors.lastname: Zilbovicius
mesh_terms: D000293:Adolescent; D001303:Auditory Cortex / Q000098:blood supply / Q000503:physiopathology; D001321:Autistic Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D013702:Temporal Lobe / Q000098:blood supply* / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods