title: Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong.
abstract: In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.
authors.affiliation: Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China. kmkam@dh-gov.hk
authors.forename: Kai Man
authors.initials: KM
authors.lastname: Kam
authors.forename: Shirley Sin Yee
authors.initials: SS
authors.lastname: Kam
authors.forename: Danny Tze Leung
authors.initials: DT
authors.lastname: Cheung
authors.forename: Viola Wai Na
authors.initials: VW
authors.lastname: Tung
authors.forename: Wai Fun
authors.initials: WF
authors.lastname: Au
authors.forename: May May
authors.initials: MM
authors.lastname: Cheung
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006723:Hong Kong; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D015242:Ofloxacin / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin