[Influence of induction chemotherapy on long-time effect of patients with tongue squamous cell carcinoma].
OBJECTIVE
Induction chemotherapy is important in comprehensive care of patients with oral tongue squamous cell carcinoma. However, the effect of induction chemotherapy on the long-time effect was not clearly known. This study was designed to investigate the relationship between pathological negativity of primary lesion after induction chemotherapy and long-time effect in tongue squamous cell carcinoma.


METHODS
The 3 year survival rate, the 5 year survival rate, survival rate with tumor free, and reasons of treatment failure of 25 patients with tongue squamous cell carcinoma which primary lesion was pathologically negative were analyzed retrospectively.


RESULTS
The 3 year survival rate and the 5 year survival rate of the patients which primary lesion (91.75% and 91.66%) was pathologically negative were both higher than the patients with residual tumor (64.52% and 57.0%). The survival rate with tumor free in the former was also higher than that in the latter. The main reasons for treatment failure were local recurrence and/or regional lymph node metastasis/recurrence.


CONCLUSIONS
Induction chemotherapy could increase the long-time survival rate of the patients with tongue squamous cell carcinoma whose primary lesion was pathologically negative.
Hua
Hui
H
Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China.
Zeng
Zong-yuan
ZY
Zhao
Hua
H
Chen
Fu-jin
FJ
Guo
Zhu-ming
ZM
Xu
Guang-pu
GP
Zhang
Quan
Q
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D016896:Treatment Outcome