title: [Assessment of variables relative to prethrombotic state after operation in patients with gynecological malignancies].
abstract: OBJECTIVE
  To study the changes in the variables in patients with gynecological malignancies after operation.
  
  
  METHODS
  Platelet alphagranule membrane protein (GMP-140), von Willebrand Factor (vWF), antithrombin III activity (AT-III), protein C-dependent partial thromboplastin activation time, plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI), D-Dimer were examined in 20 normal non-pregnant women and 38 patients after operation with gynecological malignancies.
  
  
  RESULTS
  vWF, GMP-140, PLG, D-Dimer, and PAI of patients with malignancies before operation were obviously higher than those of the healthy women (P<0.01). After operation the parameters were obviously elevated in the patients (P<0.01). AT-III and partial thromboplastin activation time were significantly reduced in comparison with the healthy subjects (P<0.01). t-PA showed no significant difference between the groups (P>0.05).
  
  
  CONCLUSIONS
  Obvious prethrombotic state characterizes the patients with gynecological malignancies after operation.
authors.affiliation: Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Bao-ying
authors.initials: BY
authors.lastname: Liu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Yu
authors.forename: Jing-shan
authors.initials: JS
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D005833:Genital Neoplasms, Female / Q000097:blood / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D020246:Venous Thrombosis / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D019007:P-Selectin; D014841:von Willebrand Factor; D000990:Antithrombin III