Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.
Sun
Lijiang
L
Department of Urology, Huashan Hospital, School of Medicine, Fudan University, Shanghai, P. R. China.
Li
Yujun
Y
Shi
Jingsen
J
Wang
Xiao
X
Wang
Xiang
X
D000818:Animals; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000097:blood; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D008315:Malondialdehyde / Q000097:blood; D011719:Pyrazines / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000187:drug effects* / Q000473:pathology; D015427:Reperfusion Injury / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood
D019332:Endothelin-1; D016166:Free Radical Scavengers; D011719:Pyrazines; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C017953:tetramethylpyrazine