Successful treatment of radiation nephropathy with angiotensin II blockade.
OBJECTIVE
The aim of this report is to document the successful treatment of radiation nephropathy.


METHODS
Clinical case report with statistical analysis of evolution of kidney function.


RESULTS
A case of radiation nephropathy was found in a kidney transplant recipient whose kidney transplant had been irradiated with 750 cGy 23 years previously. Use of the angiotensin II blocker, losartan, was associated with significant stabilization of the kidney function.


CONCLUSIONS
Radiation nephropathy can be successfully treated. Other normal-tissue radiation injuries may also be treatable.
Cohen
Eric P
EP
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. ecohen@ncw.edu
Hussain
Syed
S
Moulder
John E
JE
D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000528:radiation effects*; D016030:Kidney Transplantation; D011878:Radiotherapy / Q000009:adverse effects*
D000804:Angiotensin II