[The lymphocyte subset and blood interleukin-2 level in children with Henoch-Schönlein purpura before and after cimetidine treatment].
The objective of this study was to evaluate the effect of cimetidine treatment on cellular immunity in children with Henoch-Schönlein purpura. T cell subset was detected by double marker flow cytometry and the level of IL-2 in peripheral blood was measured by MTT method, before and after cimetidine treatment. The results showed that CD3+, CD4+ T cell subset, CD4+/CD8+ ratio, and blood IL-2 level increased after the treatment (P < 0.05). There was no significant change in CD8+ T subset after the treatment. These findings indicate that cimetidine can promote T lymphocyte proliferation and differentiation, especially TH1 lymphocyte activity.
Zhao
G
G
Department of Pediatrics, Second Affiliated Hospital, WCUMS, Chengdu 610041.
Fu
R
R
Yang
C
C
Luo
C
C
Li
F
F
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy / Q000276:immunology*; D007376:Interleukin-2 / Q000378:metabolism*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D002927:Cimetidine