title: The potential value of the protein S-100B level as a criterion for hyperbaric oxygen treatment and prognostic marker in carbon monoxide poisoned patients.
abstract: Carbon monoxide (CO) poisoning resulting in diffuse tissue hypoxia. Cerebral hypoxia is a major cause of morbidity and mortality after CO poisoning. There are some clinical criteria that could help a physician to make a decision concerning the application of hyperbaric oxygenation therapy. However, it would be convenient to discover an objective biochemical serum marker that could help in the grade evaluation of CO poisoning and indication of therapy in CO-poisoned patients. We present two case reports where the established criteria for the CO poisoning were not optimum for the decision regarding therapy. It seems that the S-100B protein could be used as a biochemical marker of CO induced brain injury. S-100B values could perhaps help us to select patients for hyperbaric oxygen therapy and to predict the short and long term outcome.
authors.affiliation: Poison Control Center, Ljubljana Medical Center, Zaloska cesta 7, 1000 Ljubljana, Slovenia.
authors.forename: Miran
authors.initials: M
authors.lastname: Brvar
authors.forename: Hugon
authors.initials: H
authors.lastname: Mozina
authors.forename: Josko
authors.initials: J
authors.lastname: Osredkar
authors.forename: Martin
authors.initials: M
authors.lastname: Mozina
authors.forename: Andrej
authors.initials: A
authors.lastname: Brucan
authors.forename: Matjaz
authors.initials: M
authors.lastname: Bunc
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001925:Brain Damage, Chronic / Q000209:etiology; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000401:mortality*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins