[Effects of vitamin E and vitamin C on nonenzymatic glycation and peroxidation in experimental diabetic rats].
SD rats were peritoneally injected with streptozotocin (STZ) to establish diabetic animal model. The changes of nonenzymatic glycation and peroxidation in rats supplemented with vitamin C and/or vitamin E during five weeks were investigated. It was found that the glycated hemoglobin, glycated LDL, renal cortical AGEs and MDA in sera and renal cortex significantly decreased after supplementation of vitamins E and C jointly. It was also observed that the MDA in serum and the cortex of kidney but not glycated hemoglobin, glycated LDL and AGEs significantly decreased in the groups supplemented with vitamin C or vitamin E separately. The results suggested that joint supplementation of vitamin C and vitamin E could inhibit nonenzymatic glycation obviously and peroxidation in diabetic rats and protect the kidney from damage under hyperglycemia.
Qian
P
P
Department of Public Health, Second Military Medical University, Shanghai 200433, China.
Cheng
S
S
Guo
J
J
Niu
Y
Y
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D017127:Glycation End Products, Advanced / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E / Q000494:pharmacology*
D017127:Glycation End Products, Advanced; D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid