title: MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia.
abstract: To determine if MRI can predict intracerebral plasminogen activation after focal cerebral ischemia (FCI), ischemic regions detected by MRI after 48 h of permanent FCI in rats were compared with areas of increased plasminogen activation, defined by histological zymography after 72 h of ischemia. The overlap between areas of MRI alterations (64.5% +/- 5.4% of total ischemic hemisphere) and areas with increased plasminogen activation (62.2% +/- 3.6%) was significant for the hemisphere (p < 0.001), the cortex (p < 0.05), and the basal ganglia (p < 0.05). Thus, MRI can predict the extent of increased plasminogen activation, which may play a role in BBB-mediated post-ischemic brain edema and secondary hemorrhage.
authors.affiliation: Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 München, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pfefferkorn
authors.forename: Christoph
authors.initials: C
authors.lastname: Wiessner
authors.forename: Peter R
authors.initials: PR
authors.lastname: Allegrini
authors.forename: Christian U A
authors.initials: CU
authors.lastname: Kloss
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Hamann
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism; D011237:Predictive Value of Tests; D051381:Rats; D011916:Rats, Inbred F344; D013223:Statistics as Topic; D013687:Telencephalon / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D010958:Plasminogen; D010960:Plasminogen Activators; D020782:Matrix Metalloproteinases