[Effect of purified staphylococcal toxoid preparation on the in vitro production of interferon by leukocytes from patients with atopic dermatitis].
The impact of purified staphylococcal toxoid (PST) on the in vitro production of interferon (IFN) by blood leukocytes was evaluated. PST was found to produce a stimulating effect on the production of alpha-IFN in patients with atopic dermatitis (AD): in 88% of cases a two-fivefold increase in IFN production was observed in AD patients in comparison with healthy donors. In addition, the incubation of leukocytes obtained from atopic and nonatopic patients with PST was shown to stimulate the production of gamma-IFN by these leukocytes fivefold, on the average. These results give theoretical basis for use of PST (as an inducer of endogenic IFN) for AD patients treatment.
Mokronosova
M A
MA
Mechnikov Research Institute for Vaccines and Sera, Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Ospel'nikova
T P
TP
Liaporova
T V
TV
Ruzova
E A
EA
Grigorian
S S
SS
D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D016898:Interferon-alpha / Q000096:biosynthesis* / Q000187:drug effects; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D013208:Staphylococcal Toxoid / Q000302:isolation & purification / Q000494:pharmacology*
D016898:Interferon-alpha; D013208:Staphylococcal Toxoid; D007371:Interferon-gamma