title: Ventricular mass index using magnetic resonance imaging accurately estimates pulmonary artery pressure.
abstract: Magnetic resonance imaging (MRI) can provide accurate anatomical measurements of the cardiac ventricles. This study investigated whether a calculated ventricular mass index (VMI) would provide an accurate means of estimating pulmonary artery pressure noninvasively, and compared the results with conventional Doppler echocardiography and invasive measurement. A total of 26 subjects referred for investigation of pulmonary hypertension were studied by MRI and echocardiography within 2 weeks of cardiac catheterisation. The correlations for mean pulmonary artery pressure were as follows: VMI (ratio of right ventricular mass over left ventricular mass) r=0.81; pulmonary artery systolic pressure (echocardiography) r=0.77. The confidence intervals for the VMI were narrower than for echocardiography. Sensitivity and specificity for pulmonary hypertension were 84 and 71% respectively for the VMI compared with 89 and 57% for echocardiography. The calculated ventricular mass index provides an accurate and practical means of estimating pulmonary artery pressure noninvasively in pulmonary hypertension and may provide a more accurate estimate than Doppler echocardiography. This may be because it reflects the right ventricular response to sustained pulmonary hypertension over a long period and is not influenced by short-term physiological variables affecting echocardiography, such as heart rate, posture, hydration status and oxygen supplementation.
authors.affiliation: Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, Scotland, UK.
authors.forename: T S
authors.initials: TS
authors.lastname: Saba
authors.forename: J
authors.initials: J
authors.lastname: Foster
authors.forename: M
authors.initials: M
authors.lastname: Cockburn
authors.forename: M
authors.initials: M
authors.lastname: Cowan
authors.forename: A J
authors.initials: AJ
authors.lastname: Peacock
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016278:Ventricular Function, Right / Q000502:physiology*