title: [The measurement of tracheo-bronchial mucociliary clearance by technetium-99m DTPA aerosol scintigraphy].
abstract: Mucociliary clearance of respiratory channels is one of the important mechanisms guarding against retention of foreign particles within the lungs. Thus objective assay of the system is essential to recognizing and understanding its abnormalities. In this study, 18 healthy subjects and 32 patients with chronic obstructive pulmonary diseases (COPD) were examined by technetium-99m-DTPA aerosol scintigraphy. Monitoring was performed by visual inspection (cinescintigraphy) and quantitative analysis. The mucociliary clearance rates of 18 healthy subjects and 32 COPD patients were 3.89 +/- 0.92 mm/min and 1.32 +/- 0.59 mm/min respectively. Statistical analysis indicated that the airway clearance rate and mucociliary clearance rate of COPD patients were significantly lower than those of normal subjects (P < 0.01). The method of assay reported here is simple and objective. It has not only the advantage of visual inspection and quantitative analysis, but also the potential usefulness in studying other bronchial diseases and evaluating therapeutic effectiveness of drugs.
authors.affiliation: Department of Nuclear Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Deng
authors.forename: R
authors.initials: R
authors.lastname: Tian
authors.forename: A
authors.initials: A
authors.lastname: Kuang
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000328:Adult; D000336:Aerosols; D000368:Aged; D001980:Bronchi / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
chemical_list: D000336:Aerosols; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate