title: TSH stimulates leptin secretion by a direct effect on adipocytes.
abstract: Leptin is a circulating hormone secreted by adipose tIssue which acts as a signal to the central nervous system where it regulates energy homeostasis and neuroendocrine processes. Although leptin modulates the secretion of several pituitary hormones, no information is available regarding a direct action of pituitary products on leptin release. However, it has been pointed out that leptin and TSH have a coordinated pulsatility in plasma. In order to test a direct action of TSH on in vitro leptin secretion, a systematic study of organ cultures of human omental adipose tIssue was performed in samples obtained at surgery from 34 patients of both sexes during elective abdominal surgery. TSH powerfully stimulated leptin secretion by human adipose tIssue in vitro. In contrast, prolactin, ACTH, FSH and LH were devoid of action. These results suggest that leptin and the thyroid axis maintain a complex and dual relationship and open the possibility that plasmatic changes in TSH may contribute to the regulation of leptin pulses.
authors.affiliation: Department of Medicine, Research Area, Molecular Endocrinology Laboratory, Complejo Hospitalario Universitario de Santiago (CHUS), University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Menendez
authors.forename: R
authors.initials: R
authors.lastname: Baldelli
authors.forename: J P
authors.initials: JP
authors.lastname: Camiña
authors.forename: B
authors.initials: B
authors.lastname: Escudero
authors.forename: R
authors.initials: R
authors.lastname: Peino
authors.forename: C
authors.initials: C
authors.lastname: Dieguez
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000368:Aged; D005260:Female; D006801:Humans; D020738:Leptin / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009924:Organ Culture Techniques; D010907:Pituitary Hormones / Q000494:pharmacology; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000494:pharmacology*
chemical_list: D020738:Leptin; D010907:Pituitary Hormones; D013972:Thyrotropin