title: Influence of prior hyperbaric oxygen therapy in complications following microvascular reconstruction for advanced osteoradionecrosis.
abstract: OBJECTIVE
  To review surgical outcomes in the management of advanced mandibular osteoradionecrosis (ORN) with aggressive debridement and microvascular reconstruction.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary care referral center.
  
  
  METHODS
  Thirty patients with Marx stage III ORN of the mandible who underwent debridement with microvascular reconstruction. Two types of patients with stage III disease were included: those who had not received prior hyperbaric oxygen (HBO) therapy but who presented with a pathologic fracture, orocutaneous fistula, or bony resorption of the inferior border of the mandible (group 1, n = 9), and those who were classified as having stage III disease as a result of failure of previous debridement and HBO therapy (group 2, n = 21).
  
  
  METHODS
  Clinical resolution of ORN as well as surgical perioperative complications.
  
  
  METHODS
  Debridement and primary free flap reconstruction in all patients; Perioperative HBO therapy in 3 patients.
  
  
  RESULTS
  The overall complication rate was 43%, but 29 (97%) of 30 patients had clinical resolution of their ORN. There were no flap failures. After smoking status and use of perioperative HBO were adjusted for, patients with Marx stage III disease who had received prior HBO therapy (group 2) were significantly more likely to have postoperative wound infection (P =.01) and overall surgical complications (P =.04) than were patients with stage III disease who had never been treated with HBO (group 1). Perioperative HBO therapy was provided too infrequently to comment on its effectiveness.
  
  
  CONCLUSIONS
  Microvascular reconstruction is effective in the treatment of patients with mandibular ORN. Management of mandibular ORN can be successfully achieved without the use of perioperative HBO therapy. Because only 3 patients received perioperative HBO therapy, we are unable to comment on its potential benefit. Patients in whom prior HBO therapy has failed are significantly more likely to have surgical complications than are other patients with Marx stage III disease, and further study is required to improve outcomes in this subgroup of patients.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA. tjgal@u.washington.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Gal
authors.forename: Bevan
authors.initials: B
authors.lastname: Yueh
authors.forename: Neal D
authors.initials: ND
authors.lastname: Futran
mesh_terms: D000368:Aged; D016025:Bone Transplantation; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003646:Debridement; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome