[The effect of heparin on wound healing of second-degree burned rats].
OBJECTIVE
To study the effect of therapeutic effect of heparin on wound healing of second-degree burned rats.


METHODS
Deep second-degree burns with 20% of total body surface were made in 20 rats, which were randomly divided into 2 groups. The experimental group was treated subcutaneously injection with 1 ml of heparin 100 U/kg and saline solution, and the control group was treated with 1 ml of saline solution, once a day until complete healing of the burned wound. The healing time were compared, the growth of granulation tissue and collagen fibers were evaluated under light microscope, and the growth of fibroblasts were observed under electronic microscope.


RESULTS
All rats survived, the healing time of experimental group (22.8 +/- 1.87 days) were much shorter than that of control group (26.2 +/- 2.82 days) (P < 0.005). Light microscope observation showed that the growth of granulation tissue and collagen fibers of experimental group were much better than that of control group, and electronic microscope also showed that the fibroblast growth was obviously better in the experimental group.


CONCLUSIONS
Subcutaneous injection of heparin can promote wound healing.
Cen
Y
Y
Department of Plastic and Burn Surgery, First University Hospital, West China University of Medical Sciences, Chengdu Sichuan, P. R. China 610041.
Luo
P
P
Liu
X X
XX
D000818:Animals; D002056:Burns / Q000188:drug therapy*; D005260:Female; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
D006493:Heparin