title: Models for mixed irradiation with a 'reciprocal-time' pattern of the repair function.
abstract: Suzuki presented models for mixed irradiation with two and multiple types of radiation by extending the Zaider and Rossi model, which is based on the theory of dual radiation action. In these models, the repair function was simply assumed to be semi-logarithmically linear (i.e., monoexponential), or a first-order process, which has been experimentally contradicted. Fowler, however, suggested that the repair of radiation damage might be largely a second-order process rather than a first-order one, and presented data in support of this hypothesis. In addition, a second-order repair function is preferred to an n-exponential repair function for the reason that only one parameter is used in the former instead of 2n-1 parameters for the latter, although both repair functions show a good fit to the experimental data. However, according to a second-order repair function, the repair rate depends on the dose, which is incompatible with the experimental data. We, therefore, revised the models for mixed irradiation by Zaider and Rossi and by Suzuki, by substituting a 'reciprocal-time' pattern of the repair function, which is derived from the assumption that the repair rate is independent of the dose in a second-order repair function, for a first-order one in reduction and interaction factors of the models, although the underlying mechanism for this assumption cannot be well-explained. The reduction factor, which reduces the contribution of the square of a dose to cell killing in the linear-quadratic model and its derivatives, and the interaction factor, which also reduces the contribution of the interaction of two or more doses of different types of radiation, were formulated by using a 'reciprocal-time' pattern of the repair function. Cell survivals calculated from the older and the newly modified models were compared in terms of the dose-rate by assuming various types of single and mixed irradiation. The result implies that the newly modified models for mixed irradiation can express or predict cell survival more accurately than the older ones, especially when irradiation is prolonged at low dose rates.
authors.affiliation: Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. shozo@tmig.or.jp
authors.forename: Shozo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yuri
authors.initials: Y
authors.lastname: Miura
authors.forename: Shoichi
authors.initials: S
authors.lastname: Mizuno
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Furusawa
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D008954:Models, Biological; D011832:Radiation Injuries / Q000503:physiopathology*; D011853:Radiobiology; D013997:Time Factors; D014945:Wound Healing