title: Expression of receptors for melanin-concentrating hormone (MCH) in different tissues and cell lines.
abstract: Melanin-concentrating hormone (MCH) is a potent orexigenic neuropeptide and a physiological antagonist of alpha-melanocyte-stimulating hormone (alpha-MSH) in the brain as well as at peripheral sites, including the pigmentary systems of specific vertebrates. Two receptor subtypes for MCH, MCH-R1 and MCH-R2, have been cloned, but other receptor subtypes are likely to exist. Based on our own data and the current literature, we have compared the expression of different receptors for MCH in various mammalian cell lines and tissues. Summarizing all data currently available, we conclude that the two cloned MCH receptors, MCH-R1 and MCH-R2, exhibit differences in their expression pattern, although MCH-R1 is generally colocalized in all tissues where MCH-R2 expression is found. It appears that MCH-R1 is more abundant and has a wider distribution pattern than MCH-R2. Other hypothetical MCH-R subtypes may be expressed in specific tissues, e.g., in the pigment cell system.
authors.affiliation: Laboratory of Endocrinology, Department of Research (ZLF) University Hospital and University Children's Hospital, CH-4031 Basel, Switzerland.
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Schlumberger
authors.forename: Christiane
authors.initials: C
authors.lastname: Talke-Messerer
authors.forename: Urs
authors.initials: U
authors.lastname: Zumsteg
authors.forename: Alex N
authors.initials: AN
authors.lastname: Eberle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D011979:Receptors, Pituitary Hormone / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: C431280:MCHR2 protein, human; D012333:RNA, Messenger; D043562:Receptors, G-Protein-Coupled; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor