Effects of parenteral lipid infusion on DNA damage in very low birth weight infants.
Very low birth weight (VLBW) infants are known to have poorly developed antioxidant system and may be at increased risk for radical damage. Previous studies have reported higher levels of lipid peroxide products in lipid emulsion used for parenteral nutrition. To examine the direct effects of parenteral lipid infusion on DNA damage in VLBW infants, we measured urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in VLBW infants before, during, and after the parenteral lipid infusion. In both the lipid-infused and lipid-free groups, urinary 8-OHdG excretion levels at 14 days old were significantly (p < 0.01) lower than those at 2 and 7 days old. However, there were no significant differences in urinary 8-OHdG excretion levels between the lipid-infused and lipid-free groups at 2, 7, and 14 days old. Our results suggest that parenteral lipid infusion does not cause oxidative DNA damage, but irrespective of the infusion DNA damage during the first week of life is enhanced when compared with 14 days after birth in VLBW infants.
Shimizu
Toshiaki
T
Department of Pediatrics, Juntendo University School of Medicine 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. tsimizut@aol.com
Satoh
Yayoi
Y
Syoji
Hiromichi
H
Tadokoro
Rieko
R
Sinohara
Kouichi
K
Oguchi
Satoshi
S
Shiga
Seigo
S
Yamashiro
Yuichiro
Y
D000080242:8-Hydroxy-2'-Deoxyguanosine; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D010288:Parenteral Nutrition
D005217:Fat Emulsions, Intravenous; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine