title: [Effect of metal oxides on the growth, hemolytic and serologic properties of Klebsiella pneumoniae].
abstract: Silicon, dysprosium, germanium, yttrium, iron, cobalt, samarium, lutecium oxides, as well as the mixture of 8 metal oxides, at a concentration of 20 g/l were found to produce a stimulating or inhibiting effect on the growth of K. pneumoniae strains 204 and K-9. Silicon, dysprosium, germanium and yttrium oxides were shown to stimulate the growth of K. pneumoniae strain 204. Iron, cobalt, samarium and lutecium oxides, as well as the mixtures of all oxides under study, inhibited the growth of this strain. Silicon, samarium and lutecium oxides produced no effect on the growth of K. pneumoniae strain K-9; at the same time germanium and yttrium oxides stimulated the growth of these bacteria, while dysprosium, iron, cobalt oxides, as well as the mixture of all oxides, inhibited their growth. The presence of metal oxides did not change the serological activity of the cultures of both strains growing old, i.e. by 24 hours of their growth. The addition of silicon, germanium and iron oxides to the culture medium increased the hemolytic activity of K. pneumoniae strain K-9 seven to ninefold in comparison with the control grown in a synthetic nutrient medium without metal oxides. The comparison of these two strains (K-9 and 204) revealed that K. pneumoniae strain K-9 possessed greater hemolytic activity.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Aleksakhina
authors.forename: L V
authors.initials: LV
authors.lastname: Miriasova
authors.forename: I A
authors.initials: IA
authors.lastname: Basnak'ian
mesh_terms: D018533:Biomass; D003035:Cobalt / Q000494:pharmacology; D003470:Culture Media; D004419:Dysprosium / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000494:pharmacology; D005857:Germanium / Q000737:chemistry / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development*; D008187:Lutetium / Q000737:chemistry / Q000494:pharmacology; D008672:Metals, Alkali; D010087:Oxides / Q000494:pharmacology*; D012493:Samarium / Q000737:chemistry / Q000494:pharmacology; D012699:Serology; D012822:Silicon Dioxide / Q000494:pharmacology; D015019:Yttrium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003470:Culture Media; D005290:Ferric Compounds; D008672:Metals, Alkali; D010087:Oxides; D005857:Germanium; D004419:Dysprosium; C000499:ferric oxide; D003035:Cobalt; D012493:Samarium; D015019:Yttrium; D008187:Lutetium; D012822:Silicon Dioxide; C060728:cobalt oxide