[Efficacy of amixine in experimental hantavirus infection].
The experimental studies conducted on 2-week suckling mice infected with Hantaan virus, Strain 76-118) treated with oral and subcutaneous amoxine showed its prophylactic, therapeutical-and-prophylactic, and therapeutical efficiencies. Oral amoxine exhibited the highest efficiency when used in a dose of 10 mg/kg-1 96 hours before infection and throughout the incubation period. The protective efficiency was 61%. Subcutaneously, the agent was effective when three schemes for injection in a dose of 1 mg/kg-1. Its maximum effect was observed when amoxine was given by the therapeutical-and-prophylactic scheme. The death protection rate was 65%. The agent is effective in suppressing the reproduction of Hantaan virus in the brain tissue.
Loginova
S Ia
SIa
Koval'chuk
A V
AV
Borisevich
S V
SV
Khamitov
R A
RA
Pol'ianikova
G L
GL
Maksimov
V A
VA
Shuster
A M
AM
D000818:Animals; D000833:Animals, Suckling; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000821:virology; D004305:Dose-Response Relationship, Drug; D006476:Orthohantavirus / Q000187:drug effects / Q000502:physiology; D018778:Hantavirus Infections / Q000188:drug therapy* / Q000517:prevention & control*; D051379:Mice; D013994:Tilorone / Q000494:pharmacology / Q000627:therapeutic use*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D013994:Tilorone