title: [A case of acute cholestatic hepatitis associated with Orlistat].
abstract: Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved.
authors.affiliation: Department of Gastroenterology, Ajou University College of Medicine, Suwon, Korea.
authors.forename: Doh Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lee
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Hwang
authors.forename: Jai Hak
authors.initials: JH
authors.lastname: Jeung
authors.forename: Do Hyun
authors.initials: DY
authors.lastname: Kim
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000328:Adult; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007783:Lactones / Q000009:adverse effects*; D008049:Lipase / Q000037:antagonists & inhibitors; D000077403:Orlistat
chemical_list: D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat; D008049:Lipase