[The effects of postburn fluid resuscitation on the pathohistological and ultrastructural changes of multiple organs with dysfunction in severely burned dogs].
OBJECTIVE
To investigate the effects of postburn fluid resuscitation on the pathohistological and ultrastructural changes of multiple organs with dysfunction in severely burned dogs.


METHODS
Forty - four mongrel dogs were randomly divided into four groups: (1) immediate infusion (II, n = 8), (2) delayed infusion (DI, n = 15), (3) no infusion (NI, n = 14), (4) normal control (NC, n = 7). The dogs were inflicted with 50% TBSA III degree flame burn produced by napalm in concentration of 30g/L burning for 30 seconds on the back. Small pieces of tissue samples of heart, lungs, liver, kidneys and gastrointestinal tract were taken from injured dogs at 72 postburn hours (PBHs) or moribund stage for the examination with light microscope (LM) and transmission electron microscope (TEM).


RESULTS
Different degrees of blood circulation disturbance and degenerative changes were found in all above internal organs. These changes were more evident in DI than in II and NI groups.


CONCLUSIONS
Delayed postburn fluid resuscitation could induce multiple organ dysfunction in early postburn stage.
Chen
Yisheng
Y
Institute of Pathology, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China.
Shi
Jingquan
J
Wu
Jun
J
Qiao
Yiran
Y
D000818:Animals; D002056:Burns / Q000150:complications / Q000628:therapy*; D004064:Digestive System / Q000473:pathology / Q000648:ultrastructure; D004285:Dogs; D005440:Fluid Therapy; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008168:Lung / Q000473:pathology / Q000648:ultrastructure; D009102:Multiple Organ Failure / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D013997:Time Factors