title: [Effects of qufengshi prescription on release of hydrogen peroxide and interleukin-1 from peritoneal macrophage in adjuvant arthritis rat].
abstract: OBJECTIVE
  To study the mechanism of antiarthritis effects of Qufengshi Prescription.
  
  
  METHODS
  Adjuvant arthritis (AA) was applied as pathological model of rheumatoid arthritis and prednisone was used as positive control.
  
  
  RESULTS
  The Prescription at high and medium dosages significantly decreased the rising level of hydrogen peroxide and interleukin-1 in AA rats (P < 0.05), the potency being similar to prednisone.
  
  
  CONCLUSIONS
  Qufengshi Prescription Could reduce the rising level of interleukin-1 and hydrogen peroxide in AA rats, which may be part of mechanism of the antiarthritis effect.
authors.affiliation: Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhang
authors.forename: F H
authors.initials: FH
authors.lastname: Weng
authors.forename: C L
authors.initials: CL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D006861:Hydrogen Peroxide