title: Recognizing influenza in older patients with chronic obstructive pulmonary disease who have received influenza vaccine.
abstract: A substudy analysis was conducted to determine the clinical characteristics associated with symptomatic, laboratory-documented influenza (LDI) among 2215 veterans with chronic obstructive pulmonary disease who participated in Department of Veterans Affairs Cooperative Study 448 and who received trivalent inactivated influenza virus vaccine with or without intranasal live-attenuated, cold-adapted influenza vaccine. Of 585 evaluable first occurrences of acute respiratory illnesses, 94 (16%) were LDI. Respiratory symptoms of cough, sputum production, and dyspnea occurred in >90% of patients with LDI; 68% had documented or subjective fever, and 81% had myalgias. Stepwise logistic regression identified only fever and myalgia as being statistically associated with LDI. During the influenza outbreak period, the positive predictive value of fever and myalgia was 41%. Clinical criteria were poor predictors of LDI in these older, vaccinated patients with chronic lung disease. Additional studies are warranted to define optimal methods for the diagnosis of influenza among older persons with chronic obstructive pulmonary disease.
authors.affiliation: Department of Veterans Affairs Puget Sound Health Care System and University of Washington School of Medicine, Seattle, Washington 98108, USA. kneuzil@u.washington.edu
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Neuzil
authors.forename: Theresa Z
authors.initials: TZ
authors.lastname: O'Connor
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Gorse
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Nichol
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D007251:Influenza, Human / Q000150:complications* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000517:prevention & control
chemical_list: D007252:Influenza Vaccines