title: Control of bleeding in endoscopic sinus surgery: use of a novel gelatin-based hemostatic agent.
abstract: OBJECTIVE
  To determine whether FloSeal Matrix Hemostatic Sealant is a safe and effective means of controlling bleeding post-endoscopic sinus surgery (ESS) and to assess postoperative healing.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  University of Toronto.
  
  
  METHODS
  Eighteen patients with FloSeal placed on a total of 30 operative sites post-ESS. Time to cessation of bleeding was assessed intraoperatively. Patients had the operative sites assessed at 30 days postoperatively.
  
  
  METHODS
  Effectiveness of FloSeal in controlling bleeding and aiding in healing of the operative site.
  
  
  RESULTS
  FloSeal adequately controls postoperative bleeding in patients post-ESS. Healing was also not adversely affected.
  
  
  CONCLUSIONS
  FloSeal is a safe and effective treatment for controlling blood loss after EES. It may also provide support to the middle meatus as well as improve healing of the operative site compared with the use of traditional nasal packing. However, randomized clinical trials are needed to further evaluate this.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Gall
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Witterick
authors.forename: Narinder S
authors.initials: NS
authors.lastname: Shargill
authors.forename: Michael
authors.initials: M
authors.lastname: Hawke
mesh_terms: D000328:Adult; D000368:Aged; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D006470:Hemorrhage / Q000517:prevention & control*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000601:surgery*; D011135:Polysaccharides, Bacterial; D011182:Postoperative Care; D011446:Prospective Studies
chemical_list: C411004:FloSeal Matrix; D006490:Hemostatics; D011135:Polysaccharides, Bacterial; C048288:gellan gum