Precocious puberty: an endocrine manifestation in congenital toxoplasmosis.
We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH. Three of them showed low GH response to an insulin tolerance test. All the children had severe mental retardation. We emphasize that children with congenital toxoplasmosis should have their hypothalamopituitary function evaluated even in subclinical situations that could be responsible for endocrinological disturbances such as precocious puberty.
Setian
Nuvarte
N
Pediatric Endocrinology Unit, Instituto da Criança Hospital das Clinicas, São Paulo University School of Medicine, Brazil.
Andrade
Regina S F
RS
Kuperman
Hilton
H
Manna
Thais Della
TD
Dichtchekenian
Vaê
V
Damiani
Durval
D
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008572:Menarche; D011629:Puberty, Precocious / Q000209:etiology*; D012189:Retrospective Studies; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000503:physiopathology
D007986:Luteinizing Hormone