Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes.
In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.
Lim
Baek-Vin
BV
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, South, Korea.
Shin
Min-Chul
MC
Jang
Mi-Hyeon
MH
Lee
Taeck-Hyun
TH
Kim
Young-Pyo
YP
Kim
Hyun-Bae
HB
Lee
Kwang-Sik
KS
Kim
Hong
H
Kim
Ee-Hwa
EH
Kim
Chang-Ju
CJ
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D018891:Dentate Gyrus / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D008297:Male; D005894:Panax / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts