Cardioprotective effect of energostim during occlusion of coronary artery.
Experiments on dogs showed that energostim, a directly acting antihypoxant, injected 15 min after occlusion of the upper one-third of the left descending branch of the interventricular coronary artery produced a pronounced cardioprotective effect. The effect was confirmed by electron microscopy (evaluation the necrotic focus), biochemical tests of the heart and blood, and changes in intracardiac hemodynamics (recovery of systolic and diastolic functions). The cardioprotective effect of energostim greatly surpasses that of routine therapy applied during acute myocardium infarction.
Karsanov
N V
NV
Research Center of Medical Biophysics and Application of New Biomedical Technologies, Georgian Ministry of Health, Tbilisi.
Sukoyan
G V
GV
Chikobava
E A
EA
Karsanov
Z N
ZN
Yarovaya
E V
EV
Tatulashvili
D R
DR
Gorelishvili
I I
II
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003327:Coronary Disease / Q000517:prevention & control* / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D004285:Dogs; D006352:Heart Ventricles / Q000648:ultrastructure; D006439:Hemodynamics; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000517:prevention & control* / Q000628:therapy*; D017202:Myocardial Ischemia / Q000188:drug therapy; D009206:Myocardium / Q000648:ultrastructure; D009336:Necrosis; D010725:Phosphocreatine / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D010725:Phosphocreatine