Fungichromin: a substance from Streptomyces padanus with inhibitory effects on Rhizoctonia solani.
Streptomyces padanus strain PMS-702 is an antagonist of Rhizoctonia solani AG-4, the causal agent of damping-off of cabbage. Treatment of cabbage seeds with the culture filtrate of S. padanus strain PMS-702 was effective in reducing the incidence of damping-off of cabbage. The major active ingredient from the culture filtrate of S. padanus strain PMS-702 was purified by silica gel column chromatography and identified as the polyene macrolide, fungichromin, by NMR and mass spectral data. Bioassay studies showed that fungichromin had a strong antifungal activity against R. solani AG-4, and its minimum inhibitory concentration (over 90% inhibition) was found to be 72 microg/mL. This is the first report of fungichromin from S. padanus as an active ingredient for the control of Rhizoctonia damping-off of cabbage.
Shih
Hsin-Der
HD
Department of Plant Pathology, National Chung-Hsing University, Taichung, 402, Taiwan.
Liu
Yung-Chuan
YC
Hsu
Fen-Lin
FL
Mulabagal
Vanisree
V
Dodda
Rajasekhar
R
Huang
Jenn-Wen
JW
D001937:Brassica / Q000382:microbiology; D005659:Fungicides, Industrial / Q000494:pharmacology*; D018942:Macrolides; D015394:Molecular Structure; D011090:Polyenes / Q000032:analysis* / Q000302:isolation & purification / Q000493:pharmacokinetics; D012232:Rhizoctonia / Q000187:drug effects*; D013302:Streptomyces / Q000737:chemistry*
D005659:Fungicides, Industrial; D018942:Macrolides; D011090:Polyenes; C011827:fungichromin