Evaluation of solid dispersion particles prepared with SEDS.
Formation of solid solution particles in the Solution Enhanced Dispersion by Supercritical fluids (SEDS) process from a model drug and two different types of carriers, mannitol and Eudragit E100 was evaluated. The crystal properties of samples and molecular interactions were investigated with DSC and FTIR, respectively. The effect of co-crystallisation of drug and mannitol on dissolution rate was studied. Even if a true one-phase solid dispersion was not obtained, the crystal structure of both drug and mannitol was mutually affected by the presence of the other. The drug was not in highly crystalline form in the co-precipitates. The interactions between the drug and mannitol could also be identified as hydrogen bonding between the amine or hydroxyl groups of the drug and the hydroxyl groups of mannitol. These interactions and changes in the crystal structure are probably directly related to the increase in the dissolution rate observed. A true solid solution was obtained when the drug was co-processed with Eudragit E100. A clear interaction between the acid hydroxyl group of the drug and the basic carbonyl group on the Eudragit E100 was observed. SEDS was shown to be an effective process for forming intimate blends and solid solutions for the drug and two different types of carriers.
Juppo
Anne Mari
AM
AstraZeneca R&D Mölndal, S-431 83, Mölndal, Sweden. anne.juppo@astrazeneca.com
Boissier
Catherine
C
Khoo
Cynthia
C
D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008353:Mannitol / Q000138:chemical synthesis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D008353:Mannitol