title: [Ani immunomodulator Hepon inhibits hepatitis C virus replication in human cell cultures in vitro].
abstract: Antiviral activity of immunomodulator "Hepon" was evaluated in human cells culture infected with hepatitis C virus. "Hepon" presence protected human cells SW-13 from cytopathogenic effect of hepatitis C virus. Maximum antiviral effect was demonstrated by "Hepon" at concentration 1 mcg/mL. Control antiviral agent reaferon (interferon alfa-2a) was more potent as vitality protecting agent in the case of SW-13 human cells culture. "Hepon" activity is based on changes of cytokins and interferons spectrum so this immunomodulator is expected to be effective against different viruses including herpes virus and encephalocarditis virus.
authors.forename: R I
authors.initials: RI
authors.lastname: Ataullakhanov
authors.forename: R D
authors.initials: RD
authors.lastname: Holms
authors.forename: A V
authors.initials: AV
authors.lastname: Katlinskiĭ
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: A N
authors.initials: AN
authors.lastname: Narovlianskiĭ
authors.forename: M V
authors.initials: MV
authors.lastname: Mezentseva
authors.forename: F I
authors.initials: FI
authors.lastname: Ershov
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C523770:Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu