Transporters and xenobiotic disposition.
Metabolism alone does not adequately account for the observed intersubject variability in drug disposition or response. Carrier-mediated processes, or transporters, are increasingly recognized to be importantly involved in drug absorption, distribution, and excretion. Thus for many drugs, transport and metabolism must be considered together to better predict drug disposition in vivo. Accordingly, this review will outline relevant background information regarding drug transporters and the role of such transporters in the drug disposition process.
Kim
Richard B
RB
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 572 RRB1, 23rd Avenue at Pierce Avenue, Nashville, TN 37323-6602, USA. richard.kim@mcmail.vanderbilt.edu
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism; D014018:Tissue Distribution; D015262:Xenobiotics / Q000378:metabolism*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001647:Bile Acids and Salts; D002352:Carrier Proteins; D004364:Pharmaceutical Preparations; D015262:Xenobiotics; C017199:2',3'-dialdehyde ATP; D000255:Adenosine Triphosphate