title: Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
authors.affiliation: S-960 Department of Biochemistry and Biophysics, University of California in San Francisco, San Francisco, California 94143-0448, USA.
authors.forename: Janet S
authors.initials: JS
authors.lastname: Finer-Moore
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Santi
authors.forename: Robert M
authors.initials: RM
authors.lastname: Stroud
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D007700:Kinetics; D007780:Lacticaseibacillus casei / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D013379:Substrate Specificity / Q000235:genetics; D013940:Thymidylate Synthase / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism / Q000502:physiology
chemical_list: D013940:Thymidylate Synthase