[The influence of physiologic factors on the expression of striatal dopamine D2 receptors].
The aim of this study was to know whether the strain, sex, and age-related body weight of rat have influence on the expression of striatal dopamine D2 receptor. The data on striatal dopamine D2 receptor binding 125I-IBZM in 34 rats were used in the comparison between pairs of groups matched on strain, sex, and body weight. The result showed that the strain and sex of rats had no influence on the striatal dopamine D2 receptor binding 125I-IBZM, but there was a body weight-related decrease in the striatal dopamine D2 receptor binding 125I-IBZM. The results suggest that age-dependent decline of striatal dopamine D2 receptors is possible; therefore, strict age-matching is necessary to clinical studies.
Cao
G
G
Department of Nuclear Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041.
Tan
T
T
D000367:Age Factors; D000818:Animals; D001549:Benzamides; D001835:Body Weight; D002531:Cerebellum / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes; D008297:Male; D011759:Pyrrolidines; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis*; D012737:Sex Factors; D013045:Species Specificity
D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide