Synthesis and DNA strand breakage activity of some 1,4-diazepines.
Reactions of 1,3-propanediamine with alpha-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity.
Mibu
Nobuko
N
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. mibu@fukuoka-u.ac.jp
Yukawa
Miho
M
Kashige
Nobuhiro
N
Iwase
Yukiko
Y
Goto
Yoshinobu
Y
Miake
Fumio
F
Yamaguchi
Tadatoshi
T
Ito
Shigeru
S
Sumoto
Kunihiro
K
D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects* / Q000502:physiology
D001381:Azepines