title: Immunoexpression of nm23 in advanced esophageal squamous cell carcinoma.
abstract: The study was undertaken to determine the immunoexpression of protein products of nm23 genes which are thought to be potential metastasis suppressor genes, in esophageal squamous cell carcinoma, and to analyze their relationship to selected clinicopathological features (age, sex, tumour size, depth of invasion, presence of lymph nodes and distant metastasis, pathologic tumor stage, degree of cancer differentiation and vascular/lymphatic invasion), as well as to the overall survival. Immunohistochemical staining with monoclonal antibody against nm23 using LSAB2/HRP method on formalin-fixed, paraffin-embedded sections obtained from 32 tumors was performed. Eight tumors (25%) showed positive nm23 immunoexpression. There were no statistically significant differences between nm23-positive and nm23-negative groups with respect to all clinicopathological features studied. The positive nm23 status was related to a worse prognosis but this was not significant. The results may suggest that nm23-status is not associated with metastatic ability and prognosis in esophageal squamous cell carcinoma, but such thesis requires further study on a larger population.
authors.affiliation: Department of Clinical Pathomorphology, Medical University, Lublin, Poland. jszumilo@wp.pl
authors.forename: Justyna
authors.initials: J
authors.lastname: Szumiło
authors.forename: Danuta
authors.initials: D
authors.lastname: Skomra
authors.forename: Daniel
authors.initials: D
authors.lastname: Chibowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dabrowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wallner
authors.forename: Roman
authors.initials: R
authors.lastname: Maciejewski
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020559:Monomeric GTP-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D015996:Survival Rate; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism*
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins