title: Unusual imaging findings in Wilson's disease.
abstract: We present unusual imaging findings in the liver of a patient with Wilson's disease. On US, the liver contours were irregular and its echogenicity was increased with multiple, small hypo- and hyperechoic nodules. Prominent perihepatic fat layer was noted to be increased in thickness. On CT and MR, multiple, small, enhancing nodules were detected in the liver in the early arterial phase after administration of intravenous contrast material. Biopsy was consistent with chronic parenchymal liver pathology with dysplastic changes but without evidence of hepatocellular carcinoma. To our knowledge, dysplastic nodules enhancing at the arterial phase and thickened perihepatic fat layer have not been previously reported in patients with Wilson's disease.
authors.affiliation: Department of Radiology, Hacettepe University, Sihhiye/Ankara, 06100 Turkey. akhano@tr.net
authors.forename: Okan
authors.initials: O
authors.lastname: Akhan
authors.forename: Erhan
authors.initials: E
authors.lastname: Akpinar
authors.forename: Aytekin
authors.initials: A
authors.lastname: Oto
authors.forename: Mert
authors.initials: M
authors.lastname: Köroglu
authors.forename: Mustafa N
authors.initials: MN
authors.lastname: Ozmen
authors.forename: Deniz
authors.initials: D
authors.lastname: Akata
authors.forename: Bijan
authors.initials: B
authors.lastname: Bijan
mesh_terms: D000328:Adult; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional