title: [Causes of death in HIV-infected French drug users, 1995-2000].
abstract: Since the decline in mortality among HIV-infected persons after introduction of highly active antiretroviral therapy, concerns related to co-morbidities have increased as they may impair vital prognosis, particularly in intravenous (IV) drug users. We describe firstly the changes in the distribution of the causes of death between 1995 and 2000 among IV drug users in the "Aquitaine Cohort" based on hospital information system, and secondly the distribution of the causes of death among IV drug users in the French national survey "Mortalité 2000" specifically set up in 2000 for optimal exhaustiveness. The total number of deaths declined between 1995 and 2000 and 1/3 were IV drug users. Deceased IV drug users were younger than other deceased patients, had longer median time from diagnosis of HIV infection and higher median CD4 cell count. Poor socio-economic conditions were notified in 55%. Among IV drug users, the proportion of AIDS-related deaths was above 75% in 1995 and below 30% in 2000. In 2000, 25% of deaths were HCV-related, 12% of deaths were due to accident, overdose or suicide, and 8% were due to non-AIDS non-HCV related cancer. Among IV drug users, improvement in vital prognosis requires to improve management of HCV infection and to take into account socio-economic conditions and other addictive behaviours like alcohol consumption and smoking.
authors.affiliation: INSERM U330, 146, rue Léo-Saignat, 33076 Bordeaux Cedex.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Lewden
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
authors.forename: Sibylle
authors.initials: S
authors.lastname: Bevilacqua
authors.forename: Laurence
authors.initials: L
authors.lastname: Heripret
authors.forename: Thierry
authors.initials: T
authors.lastname: May
authors.forename: Philippe
authors.initials: P
authors.lastname: Morlat
authors.forename: Eric
authors.initials: E
authors.lastname: Jougla
authors.forename: François
authors.initials: F
authors.lastname: Dabis
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon
mesh_terms: D000328:Adult; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005602:France; D015658:HIV Infections / Q000150:complications / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000150:complications / Q000401:mortality*