title: Chemoembolization for hepatic metastases.
abstract: Liver metastases are one of the most difficult therapeutic challenges in modern oncologic practice. Few systemic therapies are effective for solid tumors in the liver. Resection is possible in a minority of patients and usually not curative. Image-guided therapies such as chemoembolization offer substantial intensification of treatment by combining tumor ischemia, increased drug concentrations, prolonged dwell time, and reduced systemic toxicity. Although not a curative therapy, durable responses are seen in most adenocarcinomas, which may contribute to prolongation and preservation of quality of life by delaying liver failure in patients with liver-dominant disease.
authors.affiliation: Division of Interventional Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gee
authors.forename: Michael C
authors.initials: MC
authors.lastname: Soulen
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D018278:Carcinoma, Neuroendocrine / Q000556:secondary / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy*; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D018579:Patient Selection; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed