title: Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model.
abstract: The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitami, Toyama 930-0194, Japan.
authors.forename: Huiying
authors.initials: H
authors.lastname: Li
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Miyahara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Quan Le
authors.initials: QL
authors.lastname: Tran
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001599:Berberine / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D039321:Hydrastis / Q000737:chemistry; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D010024:Osteoporosis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D029626:Ranunculaceae / Q000737:chemistry
chemical_list: D001599:Berberine