Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua.
In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin B, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including (1)H-(15)N HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.
Orabi
Khaled Y
KY
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. kyorabi@ksu.edu.sa
El Sayed
Khalid A
KA
Hamann
Mark T
MT
Dunbar
D Chuck
DC
Al-Said
Mansour S
MS
Higa
Tatsuo
T
Kelly
Michelle
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019156:Indian Ocean; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013237:Stereoisomerism
D000470:Alkaloids; D000962:Antimalarials; D000995:Antitubercular Agents; D011807:Quinolizines; C455173:araguspongine C; C473164:araguspongine K; C473163:araguspongine L; D012293:Rifampin