FC gamma RIIa polymorphism in patients with rheumatoid arthritis.
OBJECTIVE
Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2.


METHODS
Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers.


RESULTS
No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype.


CONCLUSIONS
The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.
Pawlik
A
A
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Academy of Medicine, 70-111 Szczecin, ul. Powst. Wlkp. 72, Poland.
Ostanek
L
L
Brzosko
I
I
Brzosko
M
M
Fabrycy
I Fiedorowicz
IF
Florczak
M
M
Szklarz
B Gawronska
BG
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D004247:DNA / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*
D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG; D004247:DNA