[Effects of homoharringtonine on proliferation of human retro-ocular fibroblasts].
This is a study amied at the effects of homoharringtonine on the proliferation of human retro-ocular fibroblasts. The human retroocular fibroblasts (HROFb) were cultured and MTT colorimetry assay was used to determine the proliferation of HROFb. The influence of homoharringtonine on the proliferation of HROFb was observed in vitro. The results showed that MTT colorimetry assay could precisely reflect the proliferation of HROFb. The absorbance was directly proportional to the number of the cells (r = 0.996, P < 0.001). The proliferation of HROFb was inhibited by the homoharringtonine and the cell proliferation percentage was correlated positively to the homoharringtonine level (r = 0.6932, P < 0.001).
An
Z
Z
Division of Endocrinology, First Affiliated Hospital, WCUMS, Chengdu, 610041.
Wei
S
S
Xu
S
S
Zhao
G
G
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005123:Eye / Q000166:cytology*; D005347:Fibroblasts / Q000166:cytology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D006248:Harringtonines / Q000494:pharmacology*; D000077863:Homoharringtonine; D006801:Humans
D006131:Growth Inhibitors; D006248:Harringtonines; D000077863:Homoharringtonine