title: [Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease].
abstract: OBJECTIVE
  Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, epsilon2, epsilon3, and epsilon4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease.
  
  
  METHODS
  We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea.
  
  
  RESULTS
  The frequencies of APOE alleles in fatty liver patients were 6.5% in epsilon2, 85.7% in epsilon3 and 7.8% in epsilon4. The corresponding frequencies in control subjects were 4.0% in epsilon2, 91.0% in epsilon3 and 5.0% in epsilon4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE epsilon2 and epsilon4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE epsilon2 and epsilon4 allele frequencies.
  
  
  CONCLUSIONS
  These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease.
authors.affiliation: Department of Internal Medicine, Chonbuk National University College of Medicine, Chonju, Korea. daeghonkim@moak.chonbuk.ac.kr
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Lee
authors.forename: Seung-Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Byoung-Sik
authors.initials: BS
authors.lastname: Mun
authors.forename: Heok-Soo
authors.initials: HS
authors.lastname: Ahn
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Park
authors.forename: Hye-Soo
authors.initials: HS
authors.lastname: Lee
authors.forename: Dae-Ghon
authors.initials: DG
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005234:Fatty Liver / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E