The InterPro Database, 2003 brings increased coverage and new features.
InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).
Mulder
Nicola J
NJ
EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. mulder@ebi.ac.uk
Apweiler
Rolf
R
Attwood
Teresa K
TK
Bairoch
Amos
A
Barrell
Daniel
D
Bateman
Alex
A
Binns
David
D
Biswas
Margaret
M
Bradley
Paul
P
Bork
Peer
P
Bucher
Phillip
P
Copley
Richard R
RR
Courcelle
Emmanuel
E
Das
Ujjwal
U
Durbin
Richard
R
Falquet
Laurent
L
Fleischmann
Wolfgang
W
Griffiths-Jones
Sam
S
Haft
Daniel
D
Harte
Nicola
N
Hulo
Nicolas
N
Kahn
Daniel
D
Kanapin
Alexander
A
Krestyaninova
Maria
M
Lopez
Rodrigo
R
Letunic
Ivica
I
Lonsdale
David
D
Silventoinen
Ville
V
Orchard
Sandra E
SE
Pagni
Marco
M
Peyruc
David
D
Ponting
Chris P
CP
Selengut
Jeremy D
JD
Servant
Florence
F
Sigrist
Christian J A
CJ
Vaughan
Robert
R
Zdobnov
Evgueni M
EM
D000818:Animals; D003196:Computer Graphics; D030562:Databases, Protein; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D014584:User-Computer Interface
D011506:Proteins