[Relationship between the changes of serum free fatty acids and insulin resistance in type 2 diabetics].
The purpose of this study was to investigate the changes of serum free fatty acids (FFA) in fasting state and absorptive state and the relationship between FFA changes and insulin resistance in the patients with type 2 diabetes (DM2). 75 g of glucose were given to 60 patients with DM2. Fasting serum FFA, serum insulin levels and the same parameters 2 h after glucose load were measured by calorimetric and RIA methods. Fasting and 2 h after oral glucose tolerance test (OGTT) plasma glucose(PG) levels were also assessed by using glucose oxidase method. The results showed the levels of serum FFA, PG and insulin of fasting and after glucose load in the patients were significantly increased and their insulin-sensitive (ISI) was remarkably decreased as compared with those in 30 normal controls, P < 0.05. Multiple stepwise regression analysis showed that the FFA level of 2 h after OGTT was negatively correlated with ISI, P = 0.0304. The results suggest that in patients with DM2, the levels of fasting and absorptive FFA are significantly elevated, which is negatively correlated with the decline of ISI, implying the association of abnormal fasting and absorptive FFA and insulin resistance in patients with type 2 diabetes.
Zhao
T
T
Division of Endocrinology/Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041.
Li
G
G
Huang
H
H
Li
X
X
Zhou
G
G
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin