title: Relationship between myocardial counts and patient weight: adjusting the injected activity in myocardial perfusion scans.
abstract: It is generally accepted that the quality of myocardial images deteriorates with increasing patient weight. This is attributed to a reduction of counts detected from the myocardium. In this paper we have looked at the count reduction in obese patients and suggest a workable algorithm to increase the injected activity to compensate for this loss of count. In this prospective study, 64 consecutive patients with normal myocardial images were selected to include a weight range of 50-120 kg. The height, weight and gender of patients were noted. Each patient had two studies (total of 128 studies), one at rest and one following stress with adenosine and 20-40 W bicycle exercise. Total myocardial counts were calculated from the back-projected views. The total myocardial counts per MBq of the injected activity were calculated. There was no significant difference in the injected activity and the size of the heart (pixel length of heart) between stress and rest, or gender of the patient. The normalized myocardial counts were not different between men and women, but the counts were slightly, although not significantly, higher ( P=NS) with adenosine and exercise (mean of 243 x 10(3) counts) compared to rest images (229 x 10(3) counts). There was a significant progressive loss of counts in patients with increasing weight, body mass index or body surface area ( P<0.001). There was no significant difference in the changes in counts with weight between male and female, or rest and stress studies. The combined data from all the studies were used to calculate the correlation coefficient and the slope of the line for reduction of cardiac counts with a patient's weight, body mass index, and body surface area. The best correlation was with patient weight ( r=0.58, P<0.001). This was used to calculate the increase in injection activity with increasing weight to maintain the same average counts as achieved in a 70 kg patient with a 400 MBq injection. We suggest that the injection activity should increase from 100% for a 70 kg patient to 140% for 110 kg, 200% for 140 kg, and 250% for a 150 kg patient.
authors.affiliation: Department of Nuclear Medicine, City Hospital NHS Trust, Birmingham B18 7QH, UK. a.notghi@bham.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Notghi
authors.forename: N
authors.initials: N
authors.lastname: Williams
authors.forename: N
authors.initials: N
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Goyle
authors.forename: L K
authors.initials: LK
authors.lastname: Harding
mesh_terms: D015992:Body Mass Index; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011786:Quality Control; D011874:Radiometry / Q000379:methods; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin