title: Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.
abstract: Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.
authors.affiliation: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Fengling
authors.initials: F
authors.lastname: Pu
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hidaka
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Jiro
authors.initials: J
authors.lastname: Takata
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Karube
authors.forename: Michihiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D024508:Tocotrienols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*; D024504:gamma-Tocopherol / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D024508:Tocotrienols; D014810:Vitamin E; D024504:gamma-Tocopherol; C082032:tocotrienol, alpha