[Effects of Nao-Yi-An granule on activity of cytochrome c oxidase in hippocampus of experimental intracerebral hemorrhagic rats].
OBJECTIVE
To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats.


METHODS
Eighty collagenase-induced ICH rats were used. At 12 h, 24 h, 2 d, 4 d, 7 d, cytochrome c oxidase(CO) activity was measured with histochemistry combined with gray scale scanning. Pyramidal cell(PC) counting was also employed following Nissl's staining.


RESULTS
The CO activities in NYA-treated group were less than those in model control group, and the neuronal loss was less in NYA-treated group than that in model control group.


CONCLUSIONS
The neuronal protective mechanism of NYA following ICH may be related with its maintaining activity of cytochrome c oxidase, which contributes to improving cellular aerobic metabolism and increasing energy supply for cells.
Tang
T
T
Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Liang
Q H
QH
Li
X Q
XQ
D000818:Animals; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000201:enzymology*; D017364:Collagenases; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006624:Hippocampus / Q000201:enzymology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D003576:Electron Transport Complex IV; D017364:Collagenases