title: Pattern of active pulmonary tuberculosis in human immunodeficiency virus seropositive adult patients in University College Hospital, Ibadan, Nigeria.
abstract: Fifty-eight confirmed HIV-seropositive adult patients were studied. All subjects were interviewed and examined. Subjects with positive respiratory symptoms and signs had their sputum examined and cultured for Mycobacterium tuberculosis (M. tuberculosis). Their chest radiograph, full blood count (FBC) and erythrocyte sedimentation rate (ESR) were also estimated. Subjects with Pulmonary tuberculosis were treated using directly observed therapy short course (DOTS) regimen. Sixty-three percent of subjects were positive for Mycobacterium tuberculosis on direct smear and/or culture. Sputum acid fast bacilli (AFB) positive subjects who completed the intensive phase of antituberculous drugs were sputum converted at 2 months. The chest x-ray finding at diagnosis showed 2 subjects (11%) with normal chest x-ray; localised lesion in 7 (37%) subjects; diffuse lesion in 7 (37%); pulmonary cavities in 3 (16%); miliary pattern in 2 (11%); pleural effusion in 2 (11%); hilar adenopathy in 2 (11%). Repeat chest-x-ray at 3 months showed complete clearance of pulmonary infiltrates in 29% whilst 71% had appreciable improvement in radiologic features. The study showed that although chest x-ray may be "normal" in sputum AFB positive HIV infected individuals, radiologic picture tends to be more diffuse and extensive. This study was therefore undertaken to determine the pattern of PTB in HIV seropositive adult patients in U.C.H., Ibadan.
authors.affiliation: Department of Medicine, University College Hospital, Ibadan, Nigeria. uchmed@skannet.Com.ng
authors.forename: O B
authors.initials: OB
authors.lastname: Awoyemi
authors.forename: O M
authors.initials: OM
authors.lastname: Ige
authors.forename: B O
authors.initials: BO
authors.lastname: Onadeko
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D000328:Adult; D017677:Age Distribution; D000995:Antitubercular Agents / Q000627:therapeutic use; D002637:Chest Pain / Q000382:microbiology / Q000821:virology; D003371:Cough / Q000382:microbiology / Q000821:virology; D003906:Developing Countries; D023801:Directly Observed Therapy; D004417:Dyspnea / Q000382:microbiology / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents