title: Immobilization stress-induced increment of lactate metabolism in the basolateral amygdaloid nucleus is attenuated by diazepam in the rat.
abstract: Using in vivo microdialysis technique, extracellular lactate levels were measured in the basolateral amygdaloid nucleus of the rat under immobilization stress. Immobilization stress (40 min) led to a tetrodotoxin-reversible increase in dialysate lactate levels. Diazepam (1.0 mg/kg, i.p.) reduced the ability of immobilization stress to increase lactate levels. Furthermore, the attenuation of the immobilization stress-induced increase of lactate levels by diazepam was antagonized by pretreatment with flumazenil (15 mg/kg, i.p.), a selective antagonist at benzodiazepine receptors. These findings suggest that immobilization stress increases lactate levels in rat basolateral amygdaloid nuclei, which is attenuated by stimulation of benzodiazepine receptors.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan. uehara@ms.toyama-mpu.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
authors.forename: Kouichi
authors.initials: K
authors.lastname: Kurata
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology* / Q000627:therapeutic use; D007103:Immobilization; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D019344:Lactic Acid; D003975:Diazepam