[GnRH receptor and the regulation of its gene expression].
The function of GnRH(gonadotropin-releasing hormone, LHRH) is mediated by GnRH receptor (GnRHR). The study on GnRHR is one of the highlights in neuroendocrinology and reproductive biology. The latest study of GnRHR, including molecular structure of GnRHR, regulation of GnRHR gene expression, distribution of GnRHR, the regulation of GnRHR by peptide and steroid hormone, as well as signal transduction mediated by GnRHR, are reviewed in the present article. Studies on GnRHR will make great contribution to the understanding of the regulation of reproduction and its action for therapy of malignant tumor.
Han
X B
XB
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080.
Cao
Y Q
YQ
Zhuang
L Z
LZ
D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis; D006801:Humans; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011966:Receptors, LHRH / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction
D012333:RNA, Messenger; D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone