title: [Which species actually exist in relation with time and pH when compounds exhibit several dissociation and kinetic constants: the striking case of a thieno-1,4-diazepine].
abstract: A solution of a molecule having several dissociation and kinetic constants evolves with time and pH-value. Now it is important from a pharmacological standpoint to know which species actually exist in solution. The knowledge of the kinetic and dissociation constants allows to plot the concentrations profiles versus time and versus pH-values of the whole protolytes. This is illustrated with a thieno-1,4-diazepine.
authors.affiliation: Laboratoire de Chimie Analytique et Bromatologie, UPRES 2231, UFR des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 2, avenue du Pr Léon-Bernard, CS 34317, F 35043 Rennes Cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Legouin
authors.forename: J L
authors.initials: JL
authors.lastname: Burgot
mesh_terms: D000465:Algorithms; D001381:Azepines / Q000737:chemistry*; D004095:Dihydropyridines / Q000737:chemistry*; D007700:Kinetics; D012996:Solutions
chemical_list: D001381:Azepines; D004095:Dihydropyridines; D012996:Solutions; C471059:thieno-1,4-diazepine