title: Biokinetics of transdermal 3-hydroxyphenazepam.
abstract: The kinetics of labeled 3-hydroxyphenazepam (active phenazepam metabolite) after its intravenous and transdermal administration was studied. Biphasic kinetic of drug distribution in the organism was revealed; pharmacokinetic parameters and biological availability (1.32  0.12 for the plasma and 1.21 0.10 for the brain) were determined on the basis of total radioactivity of the plasma and brain.
authors.affiliation: I. I. Metchnikov National University, Odessa.
authors.forename: N Ya
authors.initials: NY
authors.lastname: Golovenko
authors.forename: V B
authors.initials: VB
authors.lastname: Larionov
authors.forename: I A
authors.initials: IA
authors.lastname: Kravchenko
authors.forename: N V
authors.initials: NV
authors.lastname: Ovcharenko
authors.forename: A I
authors.initials: AI
authors.lastname: Aleksandrova
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000494:pharmacology; D019540:Area Under Curve; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D051379:Mice; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; C038294:3-hydroxyphenazepam