title: Deeply invasive candidiasis.
abstract: The incidence of invasive candidiasis is on the rise because of increasing numbers of immunocompromised hosts and more invasive medical technology. Recovery of Candida spp from several body sites in a critically ill or immunocompromised patient should raise the question of disseminated disease. Although identification to the species level and antifungal susceptibility testing should guide therapy, at this time amphotericin B preparations are the usual initial therapy for severe life-threatening disease. Azole therapy has an expanding body of evidence that proves it is as effective as and safer than amphotericin B therapy. Some forms of candidiasis (e.g., those with ocular, bone, or heart involvement) require a combined medical and surgical approach.
authors.affiliation: Division of Infectious Diseases, University of Texas-Houston Medical School, 6431 Fannin, JFB 1.728, Houston, TX 77030, USA. Luis.Ostrosky-Zeichner@uth.tmc.edu
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
authors.forename: John H
authors.initials: JH
authors.lastname: Rex
authors.forename: John
authors.initials: J
authors.lastname: Bennett
authors.forename: Bart-Jan
authors.initials: BJ
authors.lastname: Kullberg
mesh_terms: D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use*; D001393:Azoles / Q000494:pharmacology / Q000627:therapeutic use; D002177:Candidiasis / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D002985:Clinical Protocols / Q000145:classification / Q000592:standards; D004696:Endocarditis / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000453:epidemiology; D016469:Fungemia / Q000150:complications; D005658:Fungi / Q000472:pathogenicity; D005767:Gastrointestinal Diseases / Q000382:microbiology; D006801:Humans; D008172:Lung Diseases, Fungal / Q000382:microbiology; D010532:Peritoneal Diseases / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D001393:Azoles