Feasibility of an HA2 domain-based periodontitis vaccine.
In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.
DeCarlo
A A
AA
Vaccine Research Division, Agenta Biotechnologies, Birmingham, Alabama 35253, USA. adecarlo@nova.edu
Huang
Y
Y
Collyer
C A
CA
Langley
D B
DB
Katz
J
J
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D016866:Bacteroidaceae Infections / Q000517:prevention & control; D003546:Cysteine Endopeptidases / Q000008:administration & dosage / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D006454:Hemoglobins / Q000378:metabolism; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D010518:Periodontitis / Q000517:prevention & control*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344; D011994:Recombinant Proteins / Q000276:immunology
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D006454:Hemoglobins; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D003546:Cysteine Endopeptidases; C067046:gingivain