Bovine-derived bone protein extract in the treatment of mandibular Class II furcations.
This study was an initial evaluation of the use of a bovine-derived bone protein (BP) extract that contains various growth factors combined with decalcified freeze-dried bone allograft (DFDBA) as regenerative treatment for class II mandibular furcations. Twenty-five patients were divided into 5 groups according to the dosage of BP present per mg of DFDBA to be grafted: (1) 0.00 microgram/mg, (2) 3.13 micrograms/mg, (3) 6.25 micrograms/mg, (4) 12.5 micrograms/mg, and (5) 25.0 micrograms/mg. Surgical exploration of the furcation defects was performed followed by grafting with BP/DFDBA. Results at 6 months showed that attachment gain in the treated furcation areas was greatest in Groups 4 and 5, suggesting that BP has the potential to increase the effects of DFDBA in gaining clinical attachment in mandibular class II furcations.
Camargo
Paulo M
PM
School of Dentistry, University of California, Los Angeles, USA.
Wolinsky
Lawrence E
LE
Burgess
Ann V
AV
Wagner
William R
WR
Paluk
S Fabian
SF
Kenney
E Barrie
EB
D000328:Adult; D000368:Aged; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D001861:Bone Regeneration; D016025:Bone Transplantation; D002417:Cattle; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000145:classification / Q000601:surgery*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000145:classification / Q000601:surgery*; D008875:Middle Aged; D015588:Observer Variation; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D011446:Prospective Studies; D015203:Reproducibility of Results; D013223:Statistics as Topic; D013524:Surgical Flaps; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta