title: Antifertility activity of Derris brevipes variety coriacea.
abstract: Traditional physicians in and around Kotagiri village near Ootacamund, use a mixture of powdered roots of Cassia occidentalis, Derris brevipes variety coriacea and Justicia simplex to control female fertility. A mixture of powdered roots of these three plants, powdered root of Derris brevipes variety coriacea and its ethanolic extract were screened for antifertility activity in proven fertile female rats at 200 and 600 mg/kg body weight, respectively and given orally on D(1-7) of pregnancy. Both doses of the root powder of Derris brevipes variety coriacea showed 50% anti-implantation activity and also a significant reduction in the number of litters born. The ethanolic extract exhibited 40% anti-implantation activity when given orally at 600 mg/kg body weight. The rats, which continued their pregnancy, did not deliver any litters after their full term. Hence, the combined antifertility (anti-implantation and abortifacient) activity of the ethanolic extract was 100%. The results suggest that the ethanolic extract possesses more abortifacient type effect than the anti-implantation activity. The ethanolic extract also exhibited weak estrogenic activity when given alone and tested in immature ovariectomised female albino rats. But, when given along with ethinyl estradiol, it exhibited slight antiestrogenic activity. Histological and biochemical estimations were carried out to confirm this.
authors.affiliation: JSS College of Pharmacy, Rocklands, Ootacamund-643 001, India. shribadami@yahoo.com
authors.forename: Shrishailappa
authors.initials: S
authors.lastname: Badami
authors.forename: R
authors.initials: R
authors.lastname: Aneesh
authors.forename: S
authors.initials: S
authors.lastname: Sankar
authors.forename: M N
authors.initials: MN
authors.lastname: Sathishkumar
authors.forename: B
authors.initials: B
authors.lastname: Suresh
authors.forename: S
authors.initials: S
authors.lastname: Rajan
mesh_terms: D000019:Abortifacient Agents / Q000494:pharmacology / Q000633:toxicity; D000028:Abortion, Induced; D000818:Animals; D002366:Cassia / Q000737:chemistry*; D003270:Contraceptive Agents / Q000494:pharmacology* / Q000633:toxicity; D029866:Derris / Q000737:chemistry*; D010064:Embryo Implantation / Q000187:drug effects; D020847:Estrogen Receptor Modulators / Q000494:pharmacology / Q000633:toxicity; D004967:Estrogens / Q000494:pharmacology / Q000633:toxicity; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D007194:India; D027902:Justicia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000019:Abortifacient Agents; D003270:Contraceptive Agents; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D010936:Plant Extracts; D004997:Ethinyl Estradiol