Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.
This paper describes the synthesis and the antiplatelet activity of a series of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones. Some of these compounds show a dose-dependent activity and were found to be more active than their 5-substituted analogues.
Sotelo
Eddy
E
Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Esapaña.
Fraiz
Nuria
N
Yáñez
Matilde
M
Laguna
Reyes
R
Cano
Ernesto
E
Raviña
Enrique
E
D004305:Dose-Response Relationship, Drug; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines