title: [Factoral analysis related to primary recurrence of laryngeal squamous cell carcinomas after treatment].
abstract: OBJECTIVE
  This study was designed to investigate the factors associated with the primary recurrence in laryngeal squamous cell carcinomas after treatment.
  
  
  METHODS
  A total of 166 cases of laryngeal squamous cell carcinomas hospitalized in Cancer Center of Sun Yat-sen University from 1990 to 1995 were reviewed retrospectively. It was considered primary recurrence that pathologically confirmed recurrence after 6 months of follow-up. The correlative factors which included age, pathological differentiation, diseased site, stage, treatment modality, surgical procedures, surgical margin, and radiotherapy with primary recurrence were investigated.
  
  
  RESULTS
  The primary recurrence in this group after treatment was 16.3% (27/166). The primary recurrence rates in different treatment modalities of definitive radiotherapy, definitive surgery, and combined management were 50%, 8.9%, and 14.1%, respectively, which had statistical significance (P < 0.05). The primary recurrence rates in surgical and non-surgical(radiotherapy and radiochemotherapy) treatment were 11.3% and 44%, respectively, which had statistical significance(P < 0.05). The comparison of T stage in different treatment modalities showed definitive radiotherapy had earlier T stage than definitive surgery and combined therapy(P < 0.05). The primary recurrence rates in positive and negative surgical margin were 34.8% and 6.1%, respectively, which had statistical significance (P < 0.05).
  
  
  CONCLUSIONS
  The treatment of primary site influences directly the primary relapse. Surgical treatment has better primary control than non-surgical treatment. Definitive radiotherapy has more probability of primary recurrence. The surgical clearance of the primary site influences directly the primary control.
authors.affiliation: Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China. tjkzl@gzsums.edu.cn
authors.forename: Zhu-ming
authors.initials: ZM
authors.lastname: Guo
authors.forename: Zong-yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Fu-jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Liu
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guang-pu
authors.initials: GP
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome