Constituents of the fruits and leaves of Euodia daniellii.
Four flavonoid glycosides, flavaprin (7), evodioside B (8), vitexin (11), and hesperidin (12), as well as the coumarins bergapten (1), xanthotoxin (2), and isopimpinellin (3), the lignan simplexoside (10), the steroids beta-sitosterol (4) and daucosterol (5), the limonoids isolimonexic acid (6) and limonin (9), and uracil (13) and myo-inositol (14) have been isolated from Euodia daniellii. The structures of these compounds were established from spectral data. Among the isolates, bergapten showed cyclooxygenase-2 inhibitory activity with an IC50 value of 6.2 microg/ml. Flavonoids isolated from this plant exhibited no cytotoxic activity against the human tumor cell lines, A549, SKOV-3, SKMEL-2, XF498, and HCT15.
Yoo
Sang Woo
SW
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea,
Kim
Ju Sun
JS
Kang
Sam Sik
SS
Son
Kun Ho
KH
Chang
Hyeun Wook
HW
Kim
Hyun Pyo
HP
Bae
KiHwan
K
Lee
Chong-Ock
CO
D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010936:Plant Extracts