Anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura.
Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose gamma-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.
Kamei
Nozomu
N
Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima.
Yamane
Kiminori
K
Yamashita
Yasuyo
Y
Nakanishi
Shuhei
S
Watanabe
Hiroshi
H
Fujikawa
Rumi
R
Hiyama
Keiko
K
Ishioka
Shinichi
S
Mendoza
Ciro
C
Kohno
Nobuoki
N
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D034961:Antigens, Nuclear / Q000276:immunology*; D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000276:immunology*; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D000072200:Ku Autoantigen; D008713:Methimazole / Q000627:therapeutic use; D017713:Platelet Transfusion; D011441:Propylthiouracil / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000276:immunology / Q000628:therapy; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D013256:Steroids
D000893:Anti-Inflammatory Agents; D034961:Antigens, Nuclear; D013956:Antithyroid Agents; D001323:Autoantibodies; D004268:DNA-Binding Proteins; D013256:Steroids; D008713:Methimazole; D011441:Propylthiouracil; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen