title: Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.
abstract: The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan. shibuya@fupharm.fukuyama-u.ac.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
authors.forename: Chinami
authors.initials: C
authors.lastname: Kitamura
authors.forename: Shoji
authors.initials: S
authors.lastname: Maehara
authors.forename: Marie
authors.initials: M
authors.lastname: Nagahata
authors.forename: Hendig
authors.initials: H
authors.lastname: Winarno
authors.forename: Partomuan
authors.initials: P
authors.lastname: Simanjuntak
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D001711:Biotransformation; D002929:Cinchona / Q000737:chemistry / Q000382:microbiology*; D002930:Cinchona Alkaloids / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry / Q000302:isolation & purification; D010087:Oxides / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry / Q000382:microbiology
chemical_list: D002930:Cinchona Alkaloids; D010087:Oxides