Tumor cell dissemination during laparoscopy: prevention and therapeutic opportunities.
Port-site recurrences (PSRs) are abdominal wall recurrences that occur in the subcutaneous tissue within a trocar site after cancer laparoscopy and are not associated with peritoneal carcinomatosis. In order to develop PSRs, viable tumor cells must be liberated from the primary tumor, be transported to a wound, and find there a favorable environment for growth. The short clinical delay in the occurrence of PSRs and their size suggest massive cell seeding into the abdominal wall. Traumatic handling of the tumor, slipping of trocars, liquid projection, as well as poor extraction techniques can all cause implantation of malignant cells into the subcutaneous tissue. Such contact can also occur postoperatively if the trocar channels remain open. Some histologies (e.g. gallbladder adenocarcinoma), the presence of ascites and advanced tumor stage are risk factors for PSRs. Further conditions--including the use of gas--might also play a limited role. The first preventive measure is the correct indication for a laparoscopic approach. Several techniques have been demonstrated to prevent PSRs in the animal model: (a) fixation of trocars to the abdominal wall; (b) prevention of leakage; (c) careful specimen handling; (d) reducing trauma to the abdominal wall; (e) specimen isolation before extraction from the abdominal cavity; (f) trocar-site irrigation with a cytotoxic solution, and (g) closure of peritoneum. Further innovative therapies are currently under investigation. In the clinical setting, correct indication, surgical expertise and application of prophylactic measures seem to be the best way to prevent the occurrence of PSRs.
Steinert
Ralf
R
Department of Surgery, University of Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany.
Lippert
Hans
H
Reymond
Marc A
MA
D034861:Abdominal Wall / Q000473:pathology*; D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D017081:Cholecystectomy, Laparoscopic; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery; D000075202:Contraindications; D005706:Gallbladder Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D023421:Models, Animal; D009366:Neoplasm Seeding; D011677:Punctures; D013048:Specimen Handling