Effects of various storage conditions and alterations of antioxidant contents on chromatic aberration of hydroquinone ointment.
Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointments, a relatively large variability of efficacy, and mild side effects. Chromatic aberration is expected to induce non-compliance, and this may be the reason for the relatively large variability in efficacy. In this paper, the effects of various storage conditions on the chromatic aberration and HQ content of HQ ointments were evaluated, and it was suggested that the chromatic aberration was accelerated by exposure to high temperature, air and light, although these had no effect on the HQ content. In addition, various types of HQ ointments were prepared to find a formulation to minimize chromatic aberration, and it was found that the concentrations of antioxidants, Na(2)SO(3) and L(+)-ascorbic acid (AsA), seemed to be too high, and that the protective effect of AsA on chromatic aberration was mainly due to its acidifying effect.
Matsubayashi
Teruhisa
T
Department of Hospital Pharmacy, School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Sakaeda
Toshiyuki
T
Kita
Tomoko
T
Nakamura
Tsutomu
T
Kakumoto
Mikio
M
Funasaka
Yoko
Y
Ichihashi
Masamitsu
M
Fujita
Takuya
T
Kamiyama
Fumio
F
Yamamoto
Akira
A
Nordlund
James J
JJ
Kaneko
Masafumi
M
Iida
Akira
A
Okumura
Katsuhiko
K
D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D006873:Hydroquinones / Q000032:analysis* / Q000737:chemistry*; D009824:Ointments
D000975:Antioxidants; D006873:Hydroquinones; D009824:Ointments; C031927:hydroquinone