title: Estimation of actinide skeletal content in humans based on bone samples collected at autopsy.
abstract: The USTUR has developed simple linear and multiple regression models for estimating skeletal actinide concentrations on the basis of bone samples collected at autopsies of non-whole body tissue donors. Bone samples usually collected include a clavicle, the patella(e), one or more ribs, the sternum, and a vertebral wedge cut from within the abdominal cavity. The described models were derived by regression analyses with the analytical results from those bones and the entire skeletons of eight whole body donations to the USTUR. With the model, skeletal concentrations of 238Pu, (239+240)Pu, and 241Am can be estimated from wet or ashed actinide concentrations in one to five of the bones usually collected at autopsy and analyzed. Application of the models to a selected USTUR non-whole body donation (Case 0240) indicated that the skeletal actinide concentration estimates were reasonably precise and that there was good agreement between the results from individual bones with wet or ashed actinide concentrations. The USTUR will apply the model that is based on wet concentrations of bones to estimate skeletal concentrations of actinides in all non-whole body autopsy cases for the sake of consistency because of the large number of early cases for which ashed weights of bones were not recorded.
authors.affiliation: United States Transuranium and Uranium Registries, Washington State University, Tri-cities, 2710 University Drive, Richland, WA 99352, USA. rfilipy@tricity.wsu.edu
authors.forename: R E
authors.initials: RE
authors.lastname: Filipy
authors.forename: J R
authors.initials: JR
authors.lastname: Alldredge
authors.forename: C A
authors.initials: CA
authors.lastname: Hall
authors.forename: J F
authors.initials: JF
authors.lastname: McInroy
authors.forename: S E
authors.initials: SE
authors.lastname: Glover
authors.forename: S
authors.initials: S
authors.lastname: Qualls
mesh_terms: D008671:Actinoid Series Elements / Q000032:analysis*; D000368:Aged; D001822:Body Burden; D001842:Bone and Bones / Q000737:chemistry*; D002102:Cadaver; D006801:Humans; D008875:Middle Aged; D008903:Minerals / Q000737:chemistry; D008954:Models, Biological; D009994:Osmolar Concentration; D012044:Regression Analysis; D014019:Tissue Donors
chemical_list: D008671:Actinoid Series Elements; D008903:Minerals; C028705:bone ash