title: Severe prolonged red blood cell aplasia and thrombocytopenia induced by parvovirus B19 infection in a patient with sarcoidosis.
abstract: We describe an acromegalic patient who developed a parvovirus B19 (PVB19) infection concomitantly with sarcoidosis, which was complicated by chronic red blood cell aplasia and severe thrombocytopenia, despite disappearance of the virus from serum and the production of high levels of specific polyclonal antibodies to PVB19. Mitogen stimulation of the patient's peripheral blood mononuclear cells induced oversecretion of interferon-gamma (IFN-gamma). Because hematopoietic suppression by IFN-gamma has been reported, a possible mechanism underlying reticulocytopenia and thrombocytopenia could involve IFN-gamma.
authors.affiliation: Service de Médecine Interne, Hôpital Haut-Lévêque, Centre François Magendie, 33604 Pessac Cedex, France. jean-francois.viallard@chu-bordeaux.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Viallard
authors.forename: Marie
authors.initials: M
authors.lastname: Parrens
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Boiron
authors.forename: Marie-Edith
authors.initials: ME
authors.lastname: Lafon
authors.forename: Gérald
authors.initials: G
authors.lastname: Marit
authors.forename: Josy
authors.initials: J
authors.lastname: Reiffers
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pellegrin
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D010322:Parvoviridae Infections / Q000150:complications*; D017992:Parvovirus; D012010:Red-Cell Aplasia, Pure / Q000209:etiology*; D012507:Sarcoidosis / Q000150:complications* / Q000821:virology; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D007371:Interferon-gamma