title: Use of Ephedra-containing products and risk for hemorrhagic stroke.
abstract: This case-control study examined the association between Ephedra use and risk for hemorrhagic stroke. For use of Ephedra at any dose during the 3 days before the stroke, the adjusted OR was 1.00 (95% CI 0.32 to 3.11). For daily doses of < or =32 mg/day, the OR was 0.13 (95% CI 0.01 to 1.54), and for >32 mg/day, the OR was 3.59 (95% CI 0.70 to 18.35). Ephedra is not associated with increased risk for hemorrhagic stroke, except possibly at higher doses.
authors.affiliation: Stroke Program, Department of Neurology, University of Texas at Houston, USA. lmorgens@umich.edu
authors.forename: L B
authors.initials: LB
authors.lastname: Morgenstern
authors.forename: C M
authors.initials: CM
authors.lastname: Viscoli
authors.forename: W N
authors.initials: WN
authors.lastname: Kernan
authors.forename: L M
authors.initials: LM
authors.lastname: Brass
authors.forename: J P
authors.initials: JP
authors.lastname: Broderick
authors.forename: E
authors.initials: E
authors.lastname: Feldmann
authors.forename: J L
authors.initials: JL
authors.lastname: Wilterdink
authors.forename: T
authors.initials: T
authors.lastname: Brott
authors.forename: R I
authors.initials: RI
authors.lastname: Horwitz
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D029789:Ephedra / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010665:Phenylpropanolamine / Q000009:adverse effects; D008517:Phytotherapy / Q000009:adverse effects*; D028321:Plant Preparations / Q000009:adverse effects*; D018570:Risk Assessment; D020521:Stroke / Q000139:chemically induced* / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D028321:Plant Preparations; D010665:Phenylpropanolamine