[Genome shift of hepatitis E virus in Asia].
Dideoxy chain termination method was applied to sequence hepatitis E virus structure gene of Asia isolates, cDNA sequence and amino acid residues were determined. The results showed that among Asia countries: Indian, Burma, China, Pakistan and Kirghiz Republic, Hepatitis E virus genome shifted within the range of 5% and amino acid residues shifted within 1% compared with Mexico isolate. Asia Hepatitis E virus isolates have limited genome shift, which suggests recombinant Hepatitis E vaccine based on Asia HEV gene might protect all HEV infection in this area.
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Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052.
Zhuang
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Liu
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D000595:Amino Acid Sequence; D001208:Asia; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics*; D016679:Genome, Viral; D016752:Hepatitis E virus / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics*
D018076:DNA, Complementary; D004279:DNA, Viral; D015678:Viral Structural Proteins