title: [Research advances on fusion peptide and mechanisms about virus penetration into membrane].
abstract: The first step of viral infection is virus fusion with target membrane. The process is induced by fusion peptide located in glycoprotein on virus membrane. Fusion peptide exploited after interaction with receptors and penetrates into target cells membrane. Lipid molecules surrounding peptides are rearranged and membrane fusion occurs through the formation of a intermediate state. This review introduces the research advances of viral fusion peptides and its mechanism of penetrating into membrane.
authors.affiliation: Department of Biophysics, Beijing Medical University, Beijing 100083.
authors.forename: M
authors.initials: M
authors.lastname: Wu
authors.forename: S Q
authors.initials: SQ
authors.lastname: Nie
mesh_terms: D000818:Animals; D015699:HIV Envelope Protein gp120 / Q000378:metabolism / Q000502:physiology; D015497:HIV-1 / Q000378:metabolism / Q000502:physiology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000502:physiology; D006801:Humans; D009980:Influenza A virus / Q000378:metabolism / Q000502:physiology*; D008561:Membrane Fusion / Q000502:physiology*; D014760:Viral Fusion Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D015699:HIV Envelope Protein gp120; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D014760:Viral Fusion Proteins