[Detection of serum tumor supplied group of factors and its clinical significance].
OBJECTIVE
Tumor supplied group of factors (TSGF) is the first kind of tumor marker in vitro which was primarily obtained the approval by Chinese government to land the market, there was no any reports about it in abroad before. In order to know its specificity and sensitivity, we designed this study to detect the TSGF in serum of the patients with malignancies and evaluate its clinical significance for diagnosis.


METHODS
Serum TSGF in 523 cases with malignancies and 400 cases of normal control were detected with chemical colorimetry. The diagnostic accuracy was evaluated.


RESULTS
Mean levels of serum TSGF in the patients without malignancies (group A), the patients with malignancies (group B), the patients after curative treatment for malignancies (group C) and the normal control (group D) were 66.57, 71.24, 60.78, and 53.56 u/ml, respectively. After the statistical analysis, differences between the group A and group B, group A and group D, group B and group C, group B and group D, group C and group D were found (P < 0.05). But there was no obvious difference between the group A and group C (P > 0.05). The sensitivity was 63.86%; the specificity was 90.89%; the truly negative rate was 87.01%; and the falsely negative rate was 13.00%.


CONCLUSIONS
Serum TSGF increased in malignancies and may be helpful for screening and early detection of cancer.
Liang
Yi-ren
YR
Department of Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China.
Wan
De-sen
DS
Chen
Gong
G
Lu
Zhen-hai
ZH
Li
You-juan
YJ
Lin
Yue-hao
YH
Chi
Pei-dong
PD
D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor