[Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair].
OBJECTIVE
To localize the distribution of basic fibroblast growth factor (bFGF) and transforming growth factor-beta(TGF-beta) in tissues from dermal chronic ulcer and hypertrophic scar and to explore their effects on tissue repair.


METHODS
Twenty-one cases were detected to localize the distribution of bFGF and TGF-beta, among them, there were 8 cases with dermal chronic ulcers, 8 cases with hypertrophic scars, and 5 cases of normal skin.


RESULTS
Positive signal of bFGF and TGF-beta could be found in normal skin, mainly in the keratinocytes. In dermal chronic ulcers, positive signal of bFGF and TGF-beta could be found in granulation tissues. bFGF was localized mainly in fibroblasts cells and endothelial cells and TGF-beta mainly in inflammatory cells. In hypertrophic scar, the localization and signal density of bFGF was similar with those in granulation tissues, but the staining of TGF-beta was negative.


CONCLUSIONS
The different distribution of bFGF and TGF-beta in dermal chronic ulcer and hypertrophic scar may be the reason of different results of tissue repair. The pathogenesis of wound healing delay in a condition of high concentration of growth factors may come from the binding disorder of growth factors and their receptors. bFGF may be involved in all process of formation of hypertrophic scar, but TGF-beta may only play roles in the early stage.
Fu
X B
XB
304th Hospital of PLA, Beijing, P. R. China 100037. FUXB@cgw.net.cn
Sun
T Z
TZ
Yang
Y H
YH
D000328:Adult; D002056:Burns / Q000150:complications; D002908:Chronic Disease; D017439:Cicatrix, Hypertrophic / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D012883:Skin Ulcer / Q000378:metabolism* / Q000503:physiopathology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D014945:Wound Healing
D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2