title: Replicating by the clock.
abstract: The eukaryotic genome is divided into well-defined DNA regions that are programmed to replicate at different times during S phase. Active genes are generally associated with early replication, whereas inactive genes replicate late. This expression pattern might be facilitated by the differential restructuring of chromatin at the time of replication in early or late S phase.
authors.affiliation: Department of Cellular Biochemistry and Human Genetics, Hebrew University, Ein Kerem, Jerusalem 91120, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Goren
authors.forename: Howard
authors.initials: H
authors.lastname: Cedar
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D004261:DNA Replication; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D016196:S Phase / Q000502:physiology*; D013997:Time Factors
chemical_list: D002843:Chromatin