title: Membrane biochips.
abstract: Membrane-bound proteins represent the single most important class of drug targets. This article discusses the issues surrounding fabrication of membrane-protein microarrays by conventional robotic pin printing techniques. Ligand binding selectivity and specificity to G protein-coupled receptor (GPCR) microarrays are presented. The potential applications of these arrays for drug screening are discussed.
authors.affiliation: Science and Technology Division, Corning Incorporated, Corning, NY, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Fang
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Frutos
authors.forename: Brian
authors.initials: B
authors.lastname: Webb
authors.forename: Yulong
authors.initials: Y
authors.lastname: Hong
authors.forename: Ann
authors.initials: A
authors.lastname: Ferrie
authors.forename: Fang
authors.initials: F
authors.lastname: Lai
authors.forename: Joydeep
authors.initials: J
authors.lastname: Lahiri
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D019204:GTP-Binding Proteins / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry; D008567:Membranes, Artificial; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000379:methods; D011506:Proteins / Q000032:analysis / Q000737:chemistry; D018342:Receptors, Adrenergic, beta-1 / Q000032:analysis / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry; D017447:Receptors, Dopamine D1 / Q000032:analysis / Q000737:chemistry; D018028:Receptors, Neurotensin / Q000032:analysis / Q000737:chemistry
chemical_list: D008024:Ligands; D008565:Membrane Proteins; D008567:Membranes, Artificial; D011506:Proteins; D018342:Receptors, Adrenergic, beta-1; D011956:Receptors, Cell Surface; D017447:Receptors, Dopamine D1; D018028:Receptors, Neurotensin; C114036:neurotensin type 1 receptor; D019204:GTP-Binding Proteins