[Pancreatic islet cell carcinoma with multiple hepatic metastases successfully treated with a streptozocin/5-FU regimen--a case report].
A 53-year-old woman was hospitalized because of lientery and steatorrhea. CT scans revealed a pancreatic head tumor along with multiple liver tumors. The pancreatic head tumor had spread to the duodenum. Following tumor biopsy with gastrointestinal fiberscopy, we diagnosed a pancreatic malignant islet cell tumor with multiple liver metastases. Since there was no clinical evidence of recognized endocrinopathy, we diagnosed "nonfunctioning" tumor. At first we administered only 5-FU at a dose of 370 mg/m2/day continuously for two weeks. However, neither the pancreatic head tumor nor the metastatic liver tumors changed in size. We then administered streptozocin and 5-FU at doses of 1,000 mg/m2 and 370 mg/m2, respectively, every week. The patient received a total of 10 g/m2 of streptozocin. After this treatment, the enlarged metastatic liver tumors were reduced in size, with marked improvement in liver enzyme. Toxic reactions to this regimen were mild. Only grade 1 nausea and alopecia were observed during the treatment. No hematological toxicity was observed, nor, with sufficient diuresis, was nephrotoxicity, demonstrating that this regimen can be administered safely.
Arakawa
Yasuhiro
Y
Dept. of Medical Oncology, Cancer Institute Hospital.
Mizunuma
Nobuyuki
N
Aiba
Keisuke
K
Ito
Yoshinori
Y
Takahashi
Shunji
S
Irie
Tetsuya
T
Watanabe
Jyunichiro
J
Tada
Keiichiro
K
Okudaira
Taeko
T
Seki
Makoto
M
Yamaguchi
Toshiharu
T
Muto
Tetsuichiro
T
Hatake
Kiyohiko
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018273:Carcinoma, Islet Cell / Q000188:drug therapy* / Q000556:secondary*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013311:Streptozocin / Q000008:administration & dosage
D013311:Streptozocin; D005472:Fluorouracil