title: Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a case.
abstract: Unlike Chlamydia trachomatis and C. psittaci, the association of C. pneumoniae infection with immunological complications, such as reactive arthritis (ReA) or erythema nodosum (EN) has been rarely reported. Here we present the case history of a patient with C. pneumoniae community acquired pneumonia (CAP) who subsequently developed a ReA and a cutaneous vasculitis. A 45-year-old HLA B27 negative male developed an asymmetric and additive arthritis and a cutaneous leukocytoclastic vasculitis with IgM and complement papillary deposition along hypodermic vessel walls about three weeks after the onset of respiratory symptoms. The diagnosis of chronic Chlamydia pneumoniae infection was based on serology and PCR. Cultural and serological investigations for other infectious agents commonly involved in ReA were negative. This is the first report on the occurrence of two immune-based complications, associated to Chlamydia pneumoniae infection. Therefore, since this infection is very common in our population, although often asymptomatic, should be systematically considered as a common causative agent of ReA and of vasculitis.
authors.affiliation: Department of Haemathological, Pneumological and Cardiovascular Sciences and Respiratory Disease Clinic, University of Pavia, I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cascina
authors.forename: A
authors.initials: A
authors.lastname: Marone Bianco
authors.forename: P
authors.initials: P
authors.lastname: Mangiarotti
authors.forename: C M
authors.initials: CM
authors.lastname: Montecucco
authors.forename: F
authors.initials: F
authors.lastname: Meloni
mesh_terms: D016918:Arthritis, Reactive / Q000382:microbiology* / Q000473:pathology; D002690:Chlamydia Infections / Q000150:complications* / Q000473:pathology; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000473:pathology; D016133:Polymerase Chain Reaction; D000091402:Prohibitins; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000382:microbiology* / Q000473:pathology
chemical_list: D004269:DNA, Bacterial; C000717331:PHB2 protein, human; D000091402:Prohibitins