[Protective mechanism of tianmacuzhi granules in brain].
OBJECTIVE
To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia--reperfusion model.


METHODS
Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed.


RESULTS
TMC could reduce the NMDA receptor activity, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly.


CONCLUSIONS
TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.
Cao
C Y
CY
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Du
G Y
GY
Zuo
P P
PP
Liu
X F
XF
Wang
W T
WT
Zhao
Y
Y
Wang
X R
XR
Cui
H F
HF
D000818:Animals; D002545:Brain Ischemia / Q000150:complications; D002540:Cerebral Cortex / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D029595:Orchidaceae; D010946:Plants, Medicinal; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D019666:Rubiaceae
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate