title: Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue.
abstract: OBJECTIVE
  To determine the role of transoral laser microsurgery for base of tongue squamous cell carcinoma.
  
  
  METHODS
  Retrospective unicenter study of the oncologic and functional results of laser microsurgery of tongue base carcinoma performed between 1986 and 1997.
  
  
  METHODS
  University hospital department.
  
  
  METHODS
  We reviewed 48 previously untreated patients with base of tongue squamous cell carcinoma, who were treated with transoral laser microsurgery. Distribution of the T categories were T1, 2%; T2, 25%; T3, 15%; and T4, 58%; 94% belonged to the stages III and IVa. Selective neck dissection was performed in 43 patients; 23 patients underwent postoperative radiotherapy with or without simultaneous chemotherapy.
  
  
  METHODS
  Local control rate, recurrence-free and overall survival rates, mean performance status scale scores for normalcy of diet and understandability of speech.
  
  
  RESULTS
  The Kaplan-Meier 5-year local control rate was 85%. There was no local recurrence in T1 and T2 lesions, but there was a 20% local recurrence rate in T3 and T4 tumors. Kaplan-Meier 5-year recurrence-free and overall survival rates were 73% and 52%, respectively. Mean performance status scale scores were 92% for normalcy of diet and 88% for understandability of speech. Twenty-one patients survived at least 5 years after treatment. They have a preserved larynx and live without tracheostoma or gastrostomy tube.
  
  
  CONCLUSIONS
  Our concept of organ and function preserving laser microsurgery for selected patients with base of tongue cancer seems to be justified considering the achieved oncological and functional results. Final proof of the effectiveness of the new therapeutic concept presented herein requires well-designed prospective studies.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany. w.steiner@med.uni-goettingen.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steiner
authors.forename: Oliver
authors.initials: O
authors.lastname: Fierek
authors.forename: Petra
authors.initials: P
authors.lastname: Ambrosch
authors.forename: Christian P
authors.initials: CP
authors.lastname: Hommerich
authors.forename: Martina
authors.initials: M
authors.lastname: Kron
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*