[Hepatoprotective effects of gamma-L-glutamylhistamine].
The influence of gamma-GluHA and glutarylhistamine on the lipid peroxidation, cholesterol, phospholipid and liver aminotransferase activity was investigated using carbon tetrachloride-induced model of subacute liver damage. Pretreatment of rats with gamma-GluHA and glutarylhistamine prevented liver necrosis and normalized activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood plasma, lipid peroxidation in the liver and plasma, lipid profiles and cholesterol content in the liver and plasma.
Zheltukhina
G A
GA
M. V. Lomonosov Moscow State Academy of Fine Chemical Technology, 117571, Moscow, Vernadskogo pr. 86.
Nebol'sin
V E
VE
Krzhechkovskaia
V V
VV
Evstigneeva
R P
RP
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006632:Histamine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008111:Liver Function Tests; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use
C473189:N-glutarylhistamine; D020011:Protective Agents; D012838:Silymarin; C013541:gamma-glutamylhistamine; D006632:Histamine