Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.
Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf. swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.
Sirirath
Sodngam
S
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
Tanaka
Junichi
J
Ohtani
Ikuko I
II
Ichiba
Toshio
T
Rachmat
Rachmaniar
R
Ueda
Kazunori
K
Usui
Takeo
T
Osada
Hiroyuki
H
Higa
Tatsuo
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D008870:Microtubules / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D004791:Enzyme Inhibitors; D011753:Pyrones; C088446:pironetin; D010744:Phosphoric Monoester Hydrolases