[Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance].
OBJECTIVE
To the authors' knowledge, the relationship between inducible nitric oxide synthase (iNOS) and basic fibroblast growth factor (bFGF) and cervical lymph node metastasis of supraglottic squamous cell carcinoma (SGSCC) has not been addressed to date. This study was designed to investigate the effect of iNOS and bFGF on biological behavior of cervical lymph node metastasis in SGSCC.


METHODS
The authors conducted a contrast analysis for 64 patients with SGSCC (experimental group) and 33 patients with chronic laryngeal mucositis (control group). Pathologic imaging analysis was used for quantitative determination.


RESULTS
1. Positive staining site of iNOS and bFGF was concentrated in cytoplasm; bFGF was also expressed in nuclei and intracellular substance. 2. The expressions of iNOS and bFGF were significantly higher in experimental group than in control group. 3. The expression in cervical lymph node positive group was significantly higher than that in negative group. However, there was no statistical significance between primary negative-follow positive group and primary positive group.


CONCLUSIONS
The expression of iNOS and bFGF was closely associated with SGSCC, and can be considered to be a predictor for lymph node metastasis of SGSCC.
Huang
Zhan
Z
Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China.
Zeng
Zong-yuan
ZY
Guan
Mei
M
Xia
Liang-ping
LP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II
D016222:Fibroblast Growth Factor 2; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II