The control of mRNA stability in response to extracellular stimuli.
Regulated mRNA turnover is a highly important process in control of gene expression. The specific sequence elements in mRNA modulate the stability of different mRNAs, which varies considerably in response to extracellular stimuli. But the mechanistic basis for regulation of mRNA turnover remains nebulous. Recent works indicate that several signaling pathways have been implicated in regulating the decay of specific mRNA and certain ARE binding proteins mediate rapid degradation of the mRNAs. This review provides a current knowledge of diverse extracellular signals contributing to stabilization of short-lived mRNA.
Shim
Jaekyung
J
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA.
Karin
Michael
M
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D010448:Peptide Initiation Factors / Q000378:metabolism; D020871:RNA Stability / Q000502:physiology*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020218:Response Elements / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D015534:Trans-Activators