title: Comparison of three tracers for detecting sentinel lymph nodes in patients with clinical N0 lung cancer.
abstract: The goal of this pilot study was to compare three tracers for the detection of sentinel nodes in patients with lung cancer. Forty-eight patients with clinical N0 non-small cell lung cancer were enrolled. Indocyanine green (n=16) or isosulfan blue (n=18) was injected around the tumor intraoperatively, or technetium tin colloid was injected preoperatively under CT guidance (n=14). Sentinel nodes were detected in 6.3% of patients injected with indocyanine green, 50.0% of patients injected with isosulfan blue, and 64.3% of patients injected with technetium tin colloid. The detection rate achieved with indocyanine green was significantly lower than with the other two tracers. A false-negative sentinel node was seen in 1 patient using isosulfan blue. Both isosulfan blue and technetium tin colloid seem to be suitable for intraoperative sentinel node mapping in patients with lung cancer.
authors.affiliation: Department of Clinical Research, National Sanyo Hospital, 785 Higashikiwa, Ube, Yamaguchi 755-0241, Japan. ksugi@sanyou.hosp.go.jp
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugi
authors.forename: Mikihisa
authors.initials: M
authors.lastname: Fukuda
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kaneda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008175:Lung Neoplasms; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012394:Rosaniline Dyes; D021701:Sentinel Lymph Node Biopsy; D017556:Technetium Compounds; D017971:Tin Compounds
chemical_list: D012394:Rosaniline Dyes; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; C025484:iso-sulfan blue; D007208:Indocyanine Green