title: Concise and stereoselective synthesis of enamides and dienamides by a titanium-mediated coupling method.
abstract: Ynamide-titanium alkoxide complexes underwent hydrolysis or addition to aldehydes and ketones to give single, stereodefined di- or trisubstituted enamides in good yields. Alternatively, coupling of a variety of alkyne-titanium alkoxide complexes with terminal ynamides generated amino-substituted titanacyclopentadienes, hydrolysis or aldehyde addition of which afforded stereodefined dienamides. [reaction--see text]
authors.affiliation: Departments of Biological Information and Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Tanaka
authors.forename: Shuji
authors.initials: S
authors.lastname: Hirano
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Urabe
authors.forename: Fumie
authors.initials: F
authors.lastname: Sato