title: Macrocephaly and epidural involvement of T-cell acute lymphoblastic leukemia.
abstract: We describe a 2-year-old female who presented with macrocephaly and anemia. Magnetic resonance imaging revealed a diffusely enhancing epidural lesion over the sagittal frontoparietal region. Bone marrow examination confirmed the diagnosis of T-cell acute lymphoblastic leukemia. Induction chemotherapy led to hematologic remission and neuroimaging resolution of the mass. This report suggested macrocephaly could be a rare and early manifestation of leukemia in children.
authors.affiliation: Hematology/Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan.
authors.forename: Tang Her
authors.initials: TH
authors.lastname: Jaing
authors.forename: Po Cheng
authors.initials: PC
authors.lastname: Hung
authors.forename: Iou Jih
authors.initials: IJ
authors.lastname: Hung
authors.forename: Huei Shyong
authors.initials: HS
authors.lastname: Wang
authors.forename: Chao Jan
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D000740:Anemia / Q000209:etiology; D001856:Bone Marrow Examination; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004824:Epidural Space / Q000473:pathology*; D006257:Head / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D017254:Leukemic Infiltration / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D012074:Remission Induction