title: [Frontal dysfunctions in Huntington's disease -- neuropsychology and therapy].
abstract: Huntington's disease is a hereditary and progressive disease of the central nervous system. Sudden and irregular hyperkinesias are prominent. Psychopathological findings are very frequent and often proceed the decline of motor functions for years. Almost all the patients develop a dementia in later stages of the illness. This case study shows the treatment of a patient with Huntington's disease, verified by genetic analysis, with the atypical antipsychotic drug amisulpride. In this case the psychiatric disturbances and cognitive impairments were the only signs of the disease. The treatment showed an impressive improvement. Neuropsychological aspects of the disease are discussed.
authors.affiliation: NMR-Forschung am Zentralinstitut für Seelische Gesundheit, Universität Heidelberg.
authors.forename: Erik
authors.initials: E
authors.lastname: Weimer
authors.forename: Stefan
authors.initials: S
authors.lastname: Ries
authors.forename: Heike
authors.initials: H
authors.lastname: Tost
authors.forename: Dieter F
authors.initials: DF
authors.lastname: Braus
mesh_terms: D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D012919:Social Behavior; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride