Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children.
Chloroquine resistance of Plasmodium falciparum in vitro was significantly higher in isolates from patients with severe malaria than those with uncomplicated disease. This association may be due to either progression of uncomplicated to severe disease following chloroquine failure or increased virulence of chloroquine-resistant parasites. The implication of this for antimalarial treatment policy is discussed.
Olumese
P E
PE
Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria. p.olumese@skannet.com
Amodu
O K
OK
Björkman
A
A
Adeyemo
A A
AA
Gbadegesin
R A
RA
Walker
O
O
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria; D010963:Plasmodium falciparum / Q000187:drug effects; D012044:Regression Analysis
D000962:Antimalarials; D002738:Chloroquine