[Bronchial reactivity and mucosal bioamines as criteria for acute bronchitis becoming chronic].
OBJECTIVE
To study bronchial reactivity and sensitivity with consideration of histamine, serotonin and catecholamines concentration in bronchial mucosa in patients with acute bronchitis (AB) as possible criteria of its becoming chronic.


METHODS
Before the treatment 116 patients with verified AB were examined using inhalation provocative tests (IPT) with histamine, serotonin and obsidian in increasing doses. Also, external respiration function was studied. IPT were repeated after the course of treatment.


RESULTS
87 of 116 AB patients exhibited high bronchial sensitivity and reactivity to inhalations of histamine, serotonin, obsidian. In parallel, there was a rise in the levels of histamine and serotonin and a fall in the level of catecholamines in bronchial mucosa (alveolar macrophages, lymphocytes, neutrophils, mast and APUD-cells). Changes in monoamines concentration in bronchial mucosa were relevant to activity of bronchial inflammation and the presence of obstructive syndrome.


CONCLUSIONS
Persistent bronchial hyperreactivity to inhalations of histamine and obsidian along with high histamine levels and low level of catecholamines in alveolar macrophages, lymphocytes and mucus is a criterion of bronchitis transformation to chronic one.
Artem'eva
E G
EG
Latfullin
I A
IA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001980:Bronchi / Q000503:physiopathology*; D001991:Bronchitis / Q000378:metabolism* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D002908:Chronic Disease; D006632:Histamine / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism*
D002395:Catecholamines; D006632:Histamine