Relation between antibody against oxidized low-density lipoprotein and extent of coronary atherosclerosis.
OBJECTIVE
The role of antibody against oxidized low-density lipoprotein (Ab-ox-LDL) in acute myocardial infarction (AMI) and coronary artery disease (CAD) has not been fully elucidated. This study investigated the relationship between Ab-ox-LDL titers and the extent of coronary atherosclerosis, and determined the clinical significance of this antibody in AMI.


METHODS
A total of 70 patients with significant coronary atherosclerosis demonstrated by coronary angiography were recruited. These patients were divided into AMI (n = 33; mean age, 63 yr; 29 men) and chronic stable CAD (n = 37; mean age, 62 yr; 30 men) groups. Serum Ab-ox-LDL was measured using an enzyme-linked immunosorbent assay. The extent of coronary atherosclerosis was assessed by an angiographic diffuse score system.


RESULTS
In all patients, Ab-ox-LDL was significantly correlated with white blood cell count (r = 0.309; p = 0.009), but not with lipid profile or the diffuse score. Ab-ox-LDL (422.0 +/- 60.4 vs. 263.8 +/- 30.2 U/L; p = 0.018), white blood cell count (9,742 +/- 457 vs. 7,211 +/- 327/mm3; p < 0.001), and C-reactive protein (10.5 +/- 3.1 vs. 2.9 +/- 0.5 mg/L; p = 0.022) were significantly higher in patients with AMI than in those with chronic CAD. Peak creatine kinase concentration was significantly correlated with Ab-ox-LDL (r = 0.499; p = 0.003) among patients with AMI.


CONCLUSIONS
Ab-ox-LDL is higher in patients with AMI and is correlated with myocardial damage to a greater degree than with the severity of coronary atherosclerosis and lipid profiles.
Tsai
Wei-Chuan
WC
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
Li
Yi-Heng
YH
Chao
Ting-Hsing
TH
Chen
Jyh-Hong
JH
D001323:Autoantibodies / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology; D010084:Oxidation-Reduction
D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein