[Study on specificity of IgM antibody response in patients with coxsackie virus B infection].
OBJECTIVE
To study the specificity of IgM antibody response in patients with Coxsackie virus B infection.


METHODS
A Coxsackie virus B specific immunoblot assay was established for detection of CVB IgM antibody response in patients with recent CVB infection.


RESULTS
Of 28 patients' serum samples, positive by ELISA captured CVB IgM test, analysis results of specific IgM response defined by immunoblot assay revealed VP1 protein specific which was crossly reactive among CVB group.


CONCLUSIONS
This finding suggested that VP1 protein in Coxsackie virus B group potentially functioned as a predominant antigen inducing detectable IgM antibody following CVB infection.
Zhang
T
T
Capital Institute of Pediatrics, Beijing 100020, China.
Ma
G
G
Ma
L
L
D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D029822:Enterovirus B, Human / Q000276:immunology*; D004769:Enterovirus Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D009205:Myocarditis / Q000276:immunology / Q000821:virology*; D014760:Viral Fusion Proteins / Q000276:immunology
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D014760:Viral Fusion Proteins