title: Radiofrequency ablation for accessory pathways: success and variants.
abstract: BACKGROUND
  Radiofrequency ablation (RFA) is currently being advocated as the first line of therapy for symptomatic and drug refractory arrhythmias mediated by accessory pathways (APs). However, a large database on RFA for APs from India is still lacking.
  
  
  METHODS
  Four hundred thirty-four patients (298 males, (69%)), with APs who underwent RF ablation between January, 1998 and May, 2001 were included. The success and variants were evaluated retrospectively from the data.
  
  
  RESULTS
  The mean age was 36 +/- 11 years. There were 314 (73%) patients with WPW syndrome while the other 120 (27%) had concealed APs. Documented tachycardia was noted in 406 (91%) patients. Forty-six (11%) patients had associated structural heart disease (Ebstein's anomaly in 18). The procedure was successful in 414 (97%) of 425 patients in whom it was attempted. Of those unsuccessful, five had epicardial APs, four had multiple APs and two had immediate recurrence of APs. RFA was not attempted in nine parahissian pathways. Additional mechanisms were seen in 48 (11%) patients with WPW syndrome (14 (4.4%) AV nodal reentrant tachycardias, 16 (5%) additional concealed APs and 18 (5.7%) multiple APs). Coronary sinus diverticulum were detected in 23 (7.3%) patients, and Mahaim-like APs were diagnosed in 24 (6\8%) patients. The procedural and fluoroscopy time was 96 +/- 41 and 19 +/- 13 minutes, respectively. There were no deaths; three patients developed pericardial tamponade, which was promptly treated by pericardiocentesis.
  
  
  CONCLUSIONS
  Radiofrequency ablation is a safe and effective treatment for AP mediated tachycardia, especially for younger patients and children in whom life-long drug therapy may not be best option.
authors.affiliation: Department of Cardiology, Seth GS Medical College and KEM Hospital, Mumbai.
authors.forename: R
authors.initials: R
authors.lastname: Purushotham
authors.forename: S N
authors.initials: SN
authors.lastname: Kothari
authors.forename: S C
authors.initials: SC
authors.lastname: Toal
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lokhandwala
authors.forename: P G
authors.initials: PG
authors.lastname: Kerkar
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000628:therapy*; D017115:Catheter Ablation; D019091:Critical Pathways; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome