title: [Comparison of Doppler ultrasonography and hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis].
abstract: OBJECTIVE
  This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure.
  
  
  METHODS
  The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20% of the baseline were defined as responders to terlipressin.
  
  
  RESULTS
  Any Doppler ultrasonographic parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3 +/- 3.9%, -31.2 +/- 2.2% respectively). However, PVV decreased significantly not only in responders(31.7 +/- 2.4%) but also in nonresponders(29.5 +/- 6.1%).
  
  
  CONCLUSIONS
  Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis.
authors.affiliation: Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Korea.
authors.forename: Phil Ho
authors.initials: PH
authors.lastname: Jeong
authors.forename: Soon Koo
authors.initials: SK
authors.lastname: Baik
authors.forename: Yeun Jong
authors.initials: YJ
authors.lastname: Choi
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Park
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Dong Ki
authors.initials: DK
authors.lastname: Lee
authors.forename: Sang Ok
authors.initials: SO
authors.lastname: Kwon
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Joong Wha
authors.initials: JW
authors.lastname: Park
authors.forename: Nam Dong
authors.initials: ND
authors.lastname: Kim
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001783:Blood Flow Velocity; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications*; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000077585:Terlipressin; D018608:Ultrasonography, Doppler; D014690:Venous Pressure
chemical_list: D000959:Antihypertensive Agents; D008236:Lypressin; D000077585:Terlipressin