The viral control of cellular acetylation signaling.
It is becoming clear that the post-translational modification of histone and non-histone proteins by acetylation is part of an important cellular signaling process controlling a wide variety of functions in both the nucleus and the cytoplasm. Recent investigations designate this signaling pathway as one of the primary targets of viral proteins after infection. Indeed, specific viral proteins have acquired the capacity to interact with cellular acetyltransferases (HATs) and deacetylases (HDACs) and consequently to disrupt normal acetylation signaling pathways, thereby affecting viral and cellular gene expression. Here we review the targeting of cellular HATs and HDACs by viral proteins and highlight different strategies adopted by viruses to control cellular acetylation signaling and to accomplish their life cycle.
Caron
Cécile
C
Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation--Equipe chromatine et expression des gènes, Institut Albert Bonniot, France.
Col
Edwige
E
Khochbin
Saadi
S
D000123:Acetyltransferases / Q000378:metabolism; D017500:Adenovirus E1A Proteins / Q000378:metabolism*; D000818:Animals; D015696:Gene Products, tat / Q000378:metabolism*; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism
D017500:Adenovirus E1A Proteins; D015696:Gene Products, tat; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D014764:Viral Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases