title: Cell adhesion molecule regulation of nucleocytoplasmic trafficking.
abstract: Cells undergo processes such as proliferation, differentiation, and survival based upon cues that they receive from their microenvironment. Extracellular matrix adhesion molecules, such as integrins and syndecans, and cell-cell adhesion molecules, including cadherins and Ig superfamily members, convey information about the environment to the cell. It is evident that cell adhesion molecules (CAMs) regulate a variety of signaling events. An emerging theme is that one level of CAM signaling control is through regulated nucleocytoplasmic distribution of molecules that either phosphorylate or co-activate transcription factors. In this manner, CAMs control transcription events that ultimately have a strong impact on cellular processes.
authors.affiliation: MS 441, Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, MC-165, Albany, NY 12208, USA. aplina@mail.amc.edu
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Aplin
mesh_terms: D000818:Animals; D001692:Biological Transport; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D015815:Cell Adhesion Molecules; D020928:Mitogen-Activated Protein Kinases