title: Reconstruction of extended cortical sources for EEG and MEG based on a Monte-Carlo-Markov-chain estimator.
abstract: A new procedure to model extended cortical sources from EEG and MEG recordings based on a probabilistic approach is presented. The method (SPMECS) was implemented within the framework of maximum likelihood estimators. Neuronal activity generating EEG or MEG signals was characterized by the number of sources and their location and extension. Based on the noise distribution of the measured data, source configurations were associated with the according value of the likelihood function. To find the most likely source, i.e., the maximum likelihood estimator, and its level of confidence, a stochastic solver (Metropolis algorithm) was applied. The method presented supports the incorporation of virtually any constraint, e.g., based on physiological and anatomical a priori knowledge. Thus, ambiguity of the ill-posed inverse problem was reduced considerably by confining sources to the cortical surface extracted from individual MR images. The influence of different levels and types of noise on the outcome was investigated by means of simulations. Somatosensory evoked magnetic fields analyzed by the method presented suggest that larger extended cortical areas are involved in the processing of combined finger stimulation as compared to single finger stimulation.
authors.affiliation: MEG-Center, University of Tübingen, Germany.
authors.forename: Wilhelm Emil
authors.initials: WE
authors.lastname: Kincses
authors.forename: Christoph
authors.initials: C
authors.lastname: Braun
authors.forename: Stefan
authors.initials: S
authors.lastname: Kaiser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
authors.forename: Hermann
authors.initials: H
authors.lastname: Ackermann
authors.forename: Klaus
authors.initials: K
authors.lastname: Mathiak
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003198:Computer Simulation; D004569:Electroencephalography; D006801:Humans; D015225:Magnetoencephalography; D008390:Markov Chains; D008959:Models, Neurological; D009010:Monte Carlo Method; D009474:Neurons / Q000502:physiology*