Acute vascular and interstitial rejection following renal allograft transplantation in dogs.
Renal allograft transplantation was performed in four beagles. Immunosuppressive treatment using cyclosporine, mizoribin and prednisolone was continued from Day 5 pre- until Day 20 post-transplantation. Between Days 28 and 32 post-transplantation, an abrupt elevation of the serum creatinine values followed by the development of uremia was seen in all recipients. Histopathology of the allografts examined between Days 28 and 37 revealed edema, necrosis, hemorrhage and severe diffuse interstitial cellular infiltration as well as tubulitis. Glomerular changes notably included swelling of the tufts due to hypercellularity, which was consistent with transplant glomerulitis. The intrarenal arteries exhibited fibrinoid necrosis of the walls and intimal or transmural cellular infiltration. These renal lesions were consistent with those of acute vascular and interstitial rejection in humans.
Haishima
Atsuko
A
Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan.
Kawakami
Yuki
Y
Mizuno
Satoshi
S
Kageyama
Toshiaki
T
Muto
Makoto
M
Suzuki
Tatsuo
T
Inoue
Kaoru
K
Shirota
Kinji
K
D000818:Animals; D001158:Arteries / Q000276:immunology / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012263:Ribonucleosides / Q000627:therapeutic use; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D016572:Cyclosporine; D011239:Prednisolone