A web of circadian pacemakers.
The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.
Schibler
Ueli
U
Department of Molecular Biology, NCCR Frontiers in Genetics, Sciences II, University of Geneva, Switzerland. ueli.schibler@molbio.unige.ch
Sassone-Corsi
Paolo
P
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003463:Cues; D005057:Eukaryotic Cells / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D023421:Models, Animal; D013493:Suprachiasmatic Nucleus / Q000502:physiology