title: Bisphenol A levels in human urine.
abstract: The estrogenic effects of bisphenol A (BPA) have been reported in human cells (E-screen assays) and in (italic)in vivo(/italic) studies of rodents, although the latter reports remain controversial, as do the exposure levels and adverse health effects of BPA in humans. In this study we report on an analytical high-performance liquid chromatography/fluorescence method for BPA and its conjugate in human urine and on the application of this method in two student cohorts. Urine, along with information on smoking, alcohol intake, and coffee/tea consumption, was collected in two different years from two different groups of university students, 50 in 1992 and 56 in 1999. Overall, the urinary BPA levels in the students in 1992 were significantly higher than were those in 1999. The BPA levels were also positively correlated with coffee and tea consumption in the 1992 cohort but not in the 1999 cohort. We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings.
authors.affiliation: Department of Environmental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Kunugita
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Toyohi
authors.initials: T
authors.lastname: Isse
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Oyama
authors.forename: Gary L
authors.initials: GL
authors.lastname: Foureman
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Morita
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
mesh_terms: D000097:Acetonitriles; D000328:Adult; D001559:Benzhydryl Compounds; D002849:Chromatography, Gas; D003069:Coffee / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis*; D004968:Estrogens, Non-Steroidal / Q000652:urine*; D005260:Female; D005663:Furans; D006801:Humans; D007564:Japan; D008297:Male; D010636:Phenols / Q000652:urine*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013662:Tea / Q000737:chemistry; D000098826:Bisphenol A Compounds
chemical_list: D000097:Acetonitriles; D001559:Benzhydryl Compounds; D003069:Coffee; D004968:Estrogens, Non-Steroidal; D005663:Furans; D010636:Phenols; D013662:Tea; C018674:tetrahydrofuran; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C032159:acetonitrile