Detection of low-avidity immunoglobulin G in oral fluid samples: new approach for rubella diagnosis and surveillance.
Low-avidity rubella immunoglobulin G (IgG) was detected in oral fluid samples from 30 of 32 rubella IgM-positive patients (sensitivity, 94%) and from 4 of 34 IgM-negative patients (specificity, 88%). Measuring IgG avidity in oral fluid samples could improve the reliability of rubella surveillance when the incidence of the disease and the positive predictive value of IgM tests are low.
Akingbade
D
D
Enteric, Respiratory, and Neurological Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom.
Cohen
B J
BJ
Brown
D W G
DW
D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D000915:Antibody Affinity; D001826:Body Fluids / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M; D011159:Population Surveillance; D012409:Rubella / Q000175:diagnosis*; D012412:Rubella virus / Q000276:immunology; D012463:Saliva / Q000821:virology*; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C040901:rubella antibodies