Aha, another regulator for hsp90 chaperones.
A large number of key regulators controlling homeostasis and cell fate are chaperoned by the Hsp90 folding machine. In this issue of Molecular Cell, report the discovery of a new stress-regulated cochaperone, Aha1, which accelerates the dynamics of this machine.
Mayer
Matthias P
MP
Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, D-69120, Heidelberg, Germany.
Nikolay
Rainer
R
Bukau
Bernd
B
D000251:Adenosine Triphosphatases / Q000378:metabolism; D019281:Dimerization; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D011485:Protein Binding; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases