title: [Studies on metabolism of oxymatrine by human intestinal bacteria].
abstract: OBJECTIVE
  To study the oxymatrine metabolism induced by human intestinal bacteria and its absorbed metabolites in blood.
  
  
  METHODS
  TLC and HPLC were used to examine oxymatrine and its metabolites, and UV, IR, NMR and MS were used to confirm the chemical structures of the metabolites.
  
  
  RESULTS
  Oxymatrine was transformed into matrine by human intestinal bacteria metabolism in vitro. Rats were given orally oxymatrine 100 mg.kg-1 and were decapitated 3 hours after administration, and their blood was taken to examine serum metabolites by TLC and HPLC, which revealed that oxymatrine and matrine were absorbed into blood.
  
  
  CONCLUSIONS
  Oxymatrine will be transformed into matrine when it is given orally and both of the alkaloids can be absorbed to blood.
authors.affiliation: Research Centre of New Drug, Changchun College of Traditional Chinese Medicine, Changchun, 130021 Jilin, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Wang
authors.forename: Q L
authors.initials: QL
authors.lastname: Zhou
authors.forename: B X
authors.initials: BX
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D007422:Intestines / Q000382:microbiology*; D008297:Male; D011807:Quinolizines; D051381:Rats; D017208:Rats, Wistar; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines