title: Osteosarcoma over the age of forty.
abstract: The European Musculo Skeletal Oncology Society (EMSOS) has carried out a retrospective review of patients over the age of 40 years with osteosarcoma. 481 patients from 12 centres or multicentric groups were included. 42 patients had osteosarcoma arising in Paget's disease, median survival was 9 months. Patients with axial or metastatic tumours also did badly whilst 41 patients with radiation-induced osteosarcoma had a prognosis paralleling conventional osteosarcoma matched for patient age and site of the tumour. 238 patients had high grade non-metastatic osteosarcoma and had a survival of 46% at 5 years. Older patients had less chemotherapy and fared worse. Osteosarcoma in the elderly is a curable condition and warrants intensive treatment with chemotherapy and surgical resection.
authors.affiliation: Royal Orthopaedic Hospital, Bristol Road South, Birmingham B31 2AP, UK. rob.grimer@roh.nhs.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Grimer
authors.forename: S R
authors.initials: SR
authors.lastname: Cannon
authors.forename: A M
authors.initials: AM
authors.lastname: Taminiau
authors.forename: S
authors.initials: S
authors.lastname: Bielack
authors.forename: B
authors.initials: B
authors.lastname: Kempf-Bielack
authors.forename: R
authors.initials: R
authors.lastname: Windhager
authors.forename: M
authors.initials: M
authors.lastname: Dominkus
authors.forename: G
authors.initials: G
authors.lastname: Saeter
authors.forename: H
authors.initials: H
authors.lastname: Bauer
authors.forename: I
authors.initials: I
authors.lastname: Meller
authors.forename: M
authors.initials: M
authors.lastname: Szendroi
authors.forename: G
authors.initials: G
authors.lastname: Folleras
authors.forename: M
authors.initials: M
authors.lastname: San-Julian
authors.forename: J
authors.initials: J
authors.lastname: van der Eijken
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009381:Neoplasms, Radiation-Induced / Q000401:mortality / Q000628:therapy; D010001:Osteitis Deformans / Q000401:mortality / Q000628:therapy; D012516:Osteosarcoma / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D017678:Sex Distribution; D016019:Survival Analysis