title: Improving body composition and physical activity in Prader-Willi Syndrome.
abstract: OBJECTIVE
  To determine if muscle training in Prader-Willi Syndrome (PWS) can improve local body composition, physical capacity, and activity.
  
  
  METHODS
  Seventeen children and adolescents with PWS and 18 control children were enrolled in a daily short calf muscle training program for 3 months. Before (t(0)) and after 3 months of training (t(3m)), spontaneous physical activity and exercise capacity were assessed by pedometer registrations and activity protocols. Local body composition was determined by calf circumference and skinfold measurements at t(0), t(3m), and 3 months after t(3m) (t(6m)).
  
  
  RESULTS
  During training, calf skinfold decreased from 1.1 to 0.8 SD (P <.01) and calf circumference in PWS increased from 1.4 to 1.9 SD (P <.05), reflecting improved muscle mass. At t(3m), a significant increase in spontaneous physical activity (from 45% to 71%, compared with baseline data of control children, P <.05) and physical capacity (from 31%-78%, P <.01) was found.
  
  
  CONCLUSIONS
  In persons with PWS, a well-defined and easy-to-accomplish training program improves local body composition and has generalized effects on physical activity and capacity, opening up a new therapeutic option to improve metabolic conditions.
authors.affiliation: Foundation Growth Puberty Adolescence Zurich, Prevmedic, Bethanien Private Clinic, Zurich, Switzerland.
authors.forename: Urs
authors.initials: U
authors.lastname: Eiholzer
authors.forename: Yves
authors.initials: Y
authors.lastname: Nordmann
authors.forename: Dagmar
authors.initials: D
authors.lastname: l'Allemand
authors.forename: Michael
authors.initials: M
authors.lastname: Schlumpf
authors.forename: Silvia
authors.initials: S
authors.lastname: Schmid
authors.forename: Katrin
authors.initials: K
authors.lastname: Kromeyer-Hauschild
mesh_terms: D000293:Adolescent; D001823:Body Composition; D016022:Case-Control Studies; D002648:Child; D002652:Child Behavior; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000503:physiopathology; D011218:Prader-Willi Syndrome / Q000503:physiopathology*