Effect of adrenaline on the glucose uptake by the canine hindlimb.
The effect of adrenaline on the glucose uptake by a non-exercising hindlimb was studied in fasted anaesthetized dog. Glucose uptake (mg/min) was calculated as the product of the venous blood flow and anterio-venous glucose difference (A - V). Although, adrenaline caused significant increase in venous blood flow, it however, reduced significantly the (A - V) glucose level and the glucose uptake by the hindlimb. The adrenaline effects were however, abolished by pretreating the animal with propranolol, a beta-adrenergic blocker. It was therefore concluded that the skeletal muscle of the canine hindlimb is not involved in glucose homeostasis during adrenaline hyperglycemia.
Ekhelar
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AI
Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Alada
A R A
AR
Oyebola
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OD
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005215:Fasting; D005947:Glucose / Q000378:metabolism*; D006614:Hindlimb / Q000098:blood supply* / Q000378:metabolism*; D006706:Homeostasis; D006943:Hyperglycemia / Q000139:chemically induced* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012146:Rest
D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D011433:Propranolol; D005947:Glucose; D011224:Prazosin; D004837:Epinephrine