title: [Research progress on regulation of vascular endothelial barrier function].
abstract: The regulatory mechanisms of vascular endothelial barrier function are complicated. Inflammatory mediators, such as alpha-thrombin, activate phospholipases to mediate generation of IP3 and other second messengers through receptor-coupled G protein. Protein kinase C and myosin light chain kinase are then activated, leading to phosphorylation of myosin light chains, rearrangement of F-actin skeleton, interendothelial cell gap formation and increased endothelial permeability.
authors.affiliation: Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Xiao
authors.forename: G Y
authors.initials: GY
authors.lastname: Sun
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D015398:Signal Transduction; D013917:Thrombin / Q000502:physiology*
chemical_list: C109334:GPR1 protein, S cerevisiae; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D029701:Saccharomyces cerevisiae Proteins; D009219:Myosin-Light-Chain Kinase; D020929:Mitogen-Activated Protein Kinase Kinases; D010740:Phospholipases; D013917:Thrombin