title: Oral tramadol for the treatment of pain of 7-30 days' duration in children.
abstract: This open-label, multicenter trial was designed to determine the safety profile and analgesic efficacy of tramadol for the treatment of painful conditions lasting 7-30 days in 7-16-yr-old children. We found that tramadol 1-2 mg/kg per os every 4-6 h (maximal dose = 8 mg x kg(-1). d(-1), not to exceed 400 mg/d) is a safe and effective analgesic in this patient population.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Pennsylvania 19104, USA. rose@email.chop.edu
authors.forename: John B
authors.initials: JB
authors.lastname: Rose
authors.forename: Julia C
authors.initials: JC
authors.lastname: Finkel
authors.forename: Adriano
authors.initials: A
authors.lastname: Arquedas-Mohs
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Himelstein
authors.forename: Mark
authors.initials: M
authors.lastname: Schreiner
authors.forename: Robert A
authors.initials: RA
authors.lastname: Medve
mesh_terms: D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010349:Patient Compliance; D018401:Sample Size; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol