Ob/ob mice as a model of delayed gastric emptying.
Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice (P<.01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication.
Asakawa
Akihiro
A
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Japan.
Inui
Akio
A
Ueno
Naohiko
N
Makino
Susumu
S
Uemoto
Masaharu
M
Fujino
Masayuki A
MA
Kasuga
Masato
M
D000375:Aging; D000818:Animals; D048909:Diabetes Complications; D004195:Disease Models, Animal; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005746:Gastric Emptying; D018589:Gastroparesis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity
C090116:Idremcinal; D004917:Erythromycin