[Clinicopathological study of primary meningeal hemangiopericytoma].
OBJECTIVE
Meningeal hemangiopericytoma is an uncommon tumor. This study was designed to investigate the clinicopathological and biology behavior of primary meningeal hemangiopericytoma.


METHODS
Clinical data, combined with histopathology and immunohistochemistry of 20 cases of meningeal hemangiopericytoma were reviewed, in which 4 specimens were examined with electron microscope.


RESULTS
The average age of patients with primary meningeal hemangiopericytoma was 42.4 year-old (21-69 years). The ratio of male to female was 1.2: 1. Most of the patients went to hospital for the symptoms of central nervous system such as headache. The tumor could occur on any locus of the cranial or spinal dura. Grossly, many of the tumors had capsule, whose testure were tenacious, and part of them looks like fish meat. Histopathologically, the small vascular spaces in the tumor were rich, the typical antler-liked vessel could be found, the short-spindle tumor cells were around the vessel, and distributed by radiation-shape. The tumor cells were pleomorphic and atypical, and could be found mitotic activity. Staining of argyrophilic fiber: the argyrophilic fiber surrounded single tumor cell, and distributed by radiation-shape around vessel. Immunohistochemistry showed negative for S-100 protein, F VIII, EMA, GFAP and CD34, while Vim was positive. Electron microscopically, the rich bundles of 10nm long intermediate filaments could be found in tumor cells. The exobasallamina, of cells were evidenced, and distributed around single cell. Follow-up, 8 of 17 cases were relapsed (47.1%).


CONCLUSIONS
Meningeal hemangiopericytoma is a low-malignant tumor original from meningeal mesenchymal tissue. The features of histopathology, immunphenotype and ultrastructure are similar to hemangiopericytoma of the soft tissue.
Shi
Qun-li
QL
Department of Pathology, Nanjing Military General Hospital of PLA, School of Clinical Medicine, Nanjing University, Jiangsu, Nanjing, 210002, P. R. China. shizhaoyui@sina.com.cn
Chen
Xu-dong
XD
Lu
Zhen-feng
ZF
Meng
Kui
K
Jin
Xing-zao
XZ
Yan
Xiao-wen
XW
Zhou
Xiao-jun
XJ
Sheng
Chun-ning
CN
D000328:Adult; D000368:Aged; D005260:Female; D006393:Hemangiopericytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
D014746:Vimentin