[Effects of Nilestriol on reproductive system in ovariectomized rats].
The purpose of this study was to determine the effects of Nilestriol on reproductive system. Female SD rats, aged 4 months, were randomly divided into three groups. The OVX group's rats were subjected to bilateral ovariectomy, the SHAM group's rats received sham surgery; the Nilestriol(CEE3) group's rats were subjected to bilateral ovariectomy and treated with CEE3(0.15 mg/100 g BW, once a week). A computerized image analyzer was used to evaluate the endometrial pathological changes 10 weeks later. The weight of uterus was measured. The results showed that in OVX group, atrophic uteri; and atrophied endometria were noted. The weight of uterus was increased in CEE3 group, compared with that in OVX group (642.20 +/- 283.60 mg vs. 297.00 +/- 106.90 mg, P < 0.05). The volume fraction of endometrial glands was also significantly elevated in CEE3 group, compared with that in OVX group (1.84% vs 0.58%). The endometria in CEE3 group were at an early proliferative stage. These suggest that Nilestriol has a slight stimulating effect on the uteri of ovariectomized rats, including their endometria and uterine smooth muscles. Nilestriol is suited to be used in combination with progestogen.
Liu
H
H
Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041.
Xu
K
K
Tan
J
J
Yang
S
S
D000818:Animals; D001284:Atrophy; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D004964:Estriol / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D011800:Quinestrol / Q000031:analogs & derivatives; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects / Q000473:pathology*
C010722:nylestriol; D004964:Estriol; D011800:Quinestrol