Pleomorphic lipoma of the orbit: a case series and review of literature.
OBJECTIVE
Pleomorphic lipomas are rare benign tumors that can resemble a variety of malignant soft tissue tumors on histologic examination. Six cases of patients with orbital pleomorphic lipoma, one of which was proven to be bilateral, are presented.


METHODS
Retrospective, noncomparative, interventional case series with clinicopathologic correlation.


METHODS
Clinical and histologic review of 6 patients with pleomorphic lipomas of the orbit and histologic review of fat from 22 exenteration specimens and 20 other orbital procedures.


METHODS
Evidence of histologic abnormalities in histologic specimens.


RESULTS
Pleomorphic spindle cells and multinucleated cells with nuclei arranged in a floret-like pattern were present in 7 specimens from 6 patients presenting with a clinical diagnosis of orbital fat prolapse, but there were no similar cell types present in the adipose tissue of 22 exenteration or 20 other orbital specimens.


CONCLUSIONS
Pleomorphic lipoma may arise in the orbit, presenting as what was hitherto considered to be age-related epibulbar prolapse of orbital fat.
Daniel
Claire S
CS
Moorfields Eye Hospital, London, United Kingdom.
Beaconsfield
Michele
M
Rose
Geoff E
GE
Luthert
Phil J
PJ
Heathcote
J Godfrey
JG
Clark
Brian J
BJ
D000368:Aged; D005260:Female; D006801:Humans; D008067:Lipoma / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies