title: [Protective mechanism of tianmacuzhi granules in brain].
abstract: OBJECTIVE
  To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia--reperfusion model.
  
  
  METHODS
  Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed.
  
  
  RESULTS
  TMC could reduce the NMDA receptor activity, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly.
  
  
  CONCLUSIONS
  TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Cao
authors.forename: G Y
authors.initials: GY
authors.lastname: Du
authors.forename: P P
authors.initials: PP
authors.lastname: Zuo
authors.forename: X F
authors.initials: XF
authors.lastname: Liu
authors.forename: W T
authors.initials: WT
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: X R
authors.initials: XR
authors.lastname: Wang
authors.forename: H F
authors.initials: HF
authors.lastname: Cui
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications; D002540:Cerebral Cortex / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D029595:Orchidaceae; D010946:Plants, Medicinal; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D019666:Rubiaceae
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate