title: Metoclopramide for migration of naso-enteral tube.
abstract: BACKGROUND
  Enteral alimentation by feeding tube is a common problem and an efficient method of providing nutritional support to hospitalized patients with insufficient oral intake, but adequate gastrointestinal function. The use of metoclopramide, a prokinetic agent, has been recommended to achieve transpyloric placement, but its efficacy is controversial.
  
  
  OBJECTIVE
  To determine the effect of intravenous metoclopramide on transpyloric passage of the naso-enteral tube.
  
  
  METHODS
  Relevant RCTs were identified by electronic search through MEDLINE, EMBASE, LILACS and the Cochrane Controlled Trials Register databases.
  
  
  METHODS
  
  
  
  METHODS
  Adults needing enteral nutrition. Types of intervention: Intravenous or intramuscular metoclopramide compared to placebo or no intervention. Types of studies: Randomised controlled trials. Types of outcome measures: The success of migration of transpyloric intubation.
  
  
  METHODS
  The reviewers evaluated the allocation concealment, which was classified as adequate, uncertain or inadequate. Two reviewers extracted the data independently. All analyses were performed according to the intention-to-treat method.
  
  
  RESULTS
  Four studies were included and analysed. There was no statistically significant difference between intravenous or intramuscular metoclopramide administered to promote the tube migration (OR 0.65, 95% CI 0.33 to 1.28). Intravenous metoclopramide 10 mg (OR 0.68, 95% CI 0.37 to 1.23) and 20 mg (OR 0.27, 95% CI 0.01 to 10.84) were equally ineffective in facilitating transpyloric intubation.
  
  
  CONCLUSIONS
  Four studies were included and analysed. There was no statistically significant difference between intravenous or intramuscular metoclopramide administered to promote the tube migration (OR 0.65, 95% CI 0.33 to 1.28). Intravenous metoclopramide 10 mg (OR 0.68, 95% CI 0.37 to 1.23) and 20 mg (OR 0.27, 95% CI 0.01 to 10.84) were equally ineffective in facilitating transpyloric intubation.
authors.affiliation: Enfermagem, Escola Sophia Marchetti, Av. Celso Garcia 5885,ap 71 bl.1 Tatuapé., São Paulo, São Paulo, Brazil, 03063000. gtadeuccreis@uol.com.br
authors.forename: C C
authors.initials: CC
authors.lastname: Silva
authors.forename: H
authors.initials: H
authors.lastname: Saconato
authors.forename: A N
authors.initials: AN
authors.lastname: Atallah
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D004750:Enteral Nutrition / Q000295:instrumentation*; D005746:Gastric Emptying; D006801:Humans; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal / Q000379:methods*; D008787:Metoclopramide / Q000627:therapeutic use*; D011708:Pylorus; D016032:Randomized Controlled Trials as Topic
chemical_list: D000932:Antiemetics; D008787:Metoclopramide