[Interventional therapy combining Seed of Job's-stears with lipiodol for hepatoma-bearing rats].
OBJECTIVE
To study the effect of the interventional therapy of hepatoma-bearing rat by Seed of Job's-stears (SJS) injection combining with lipiodol.


METHODS
To evaluate the effect of SJS as a medicament which can be used in interventional therapy, we repeated the hepatoma-bearing rats, and treated them by interventional therapy with SJS referring to the method which Lindel set up, comparing its effect to which of chemical medicines and lipiodol.


RESULTS
SJS or lipiodol alone had an inhibiting effect to liver cancer. The tumor growth rates were 13.89%, 14.05%, and the tumor inhibiting rates reached 38.10%, 37.49%. The curative effect of the SJS/lipiodol group was the best, and its growth rate and inhibiting rate were 3.36% and 85.03%, respectively better than the SJS group and lipiodol group (P<0.01). There was no statistically significant difference between the effect of the SJS/lipiodol group and the mitomycin/lipiodol group. The survival period of SJS/lipiodol group was longer than the rest groups (P<0.01 or P<0.05).


CONCLUSIONS
The interventional therapy by SJS/lipiodol has obvious inhibitory effect on the growth of hepatoma-bearing rats, which is similar to that of MMC/lipiodol. This inhibiting effect is better than that of the SJS or lipiodol group. SJS/lipiodol can prolong the survival period of hepatoma-bearing rats obviously, and this effect is better than that of single lipiodol, SJS or MMC/lipiodol.
Huang
Ting
T
Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310006, China.
Wu
Wanyin
W
Li
Yong
Y
Zhang
Jiangang
J
Huang
Ling
L
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D031742:Coix / Q000737:chemistry*; D004359:Drug Therapy, Combination; D007459:Iodized Oil / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D016685:Mitomycin / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D016019:Survival Analysis
D010936:Plant Extracts; D016685:Mitomycin; D007459:Iodized Oil