[Study on expression of transforming growth factor-beta 3 in the liver tissues].
33 specimens of liver biopsy from patients with different types of viral hepatitis were detected for transforming growth factor-beta 3(TGF-beta 3) by immunohistochemistry. The results showed that TGF-beta 3 mainly distributed in the sinusal walls cells in sinus portal, areas fibrous, septum, hepatocytes in pseudolobes and necrotic areas of severe hepatitis. The expressing intensity of TGF-beta 3, was stronger in the cirrhosis, chronic severe hepatitis than that in the chronic and acute hepatitis. As the expression of TGF-beta 3 increased, the level of serum bilirubin ascended and plasmozyme activity was prolonged. It may be concluded that the expression of TGF-beta 3 is correlated with severe hepatitis and the progress of the liver cirrhosis.
Wang
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Y
302 Hospital of PLA, Beijing 100039.
Wang
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L
Wang
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S
D000293:Adolescent; D000328:Adult; D005260:Female; D019694:Hepatitis B, Chronic / Q000378:metabolism*; D006525:Hepatitis, Viral, Human / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D053782:Transforming Growth Factor beta3
D016212:Transforming Growth Factor beta; D053782:Transforming Growth Factor beta3