title: Palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins.
abstract: Reaction of 5,5-dimethyl-8-nonene-2,4-dione catalyzed by PdCl2(CH3CN)2 (5 mol %) in the presence of CuCl2 (2.5 equiv) at room temperature for 3 h formed 2-acetyl-3,6,6-trimethyl-2-cyclohexenone in 96% isolated yield. Palladium-catalyzed intramolecular oxidative alkylation tolerated a range of substitution and was applicable to the synthesis of spirobicyclic compounds and to the cyclization of zeta-alkenyl beta-keto esters.
authors.affiliation: Duke University, P. M. Gross Chemical Laboratory, Durham, North Carolina 27708-0346, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Pei
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Ross A
authors.initials: RA
authors.lastname: Widenhoefer