Cross neutralization of dangerous snake venoms from Africa and the Middle East using the VACSERA polyvalent antivenom. Egyptian Organization for Biological Products & Vaccines.
This study was performed to assess the ability of polyvalent snake venom anti-serum, produced by the Egyptian Organization for Biological Products & Vaccines (VACSERA), to neutralize several toxic activities of snake venoms, not only of those included in the antivenom mixture, but also some additional venoms of snakes from Egyptian, African, and Middle Eastern habitats. In general, the results revealed that polyvalent snake venom anti-serum from VACSERA is highly effective in neutralizing Egyptian snake venoms, especially Naja haje, Naja nigricolles, Naja pallida, Cerastes cerastes, Cerastes cerastes cerastes, Cerastes vipera, Pseudocerastes persicus fieldi, and Walterinnisia egyptia. The antivenom was also effective against Naja haje, Walterinnisia egyptia, and Bites aritans from Saudi Arabia. High activity was obtained against venoms from Naja haje, Naja nigricolles, and Naja pallida of Sudan, as well as the African Naja melanoleuca, Naja mossambica, Naja naja oxiana, Bites gabonica, and Vipera lebetina. Only moderate effectiveness was obtained with Echis coloratus and Echis carinatus, and the polyvalent antiserum was ineffective against the venom of Naja nivea.
Seddik
Salwa S
SS
Egyptian Organization for Biological Products & Vaccines (VACSERA), 51 Wezaret El Zeraa St., Agouza, Giza, Egypt. ms_hashem@hotmail.com
Wanas
Soheir
S
Helmy
Madiha H
MH
Hashem
Mohamed
M
D000349:Africa; D000818:Animals; D000997:Antivenins / Q000276:immunology / Q000302:isolation & purification / Q000627:therapeutic use*; D003429:Cross Reactions; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000628:therapy; D006470:Hemorrhage / Q000139:chemically induced / Q000628:therapy; D006736:Horses / Q000276:immunology; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D051379:Mice; D008877:Middle East; D009500:Neutralization Tests / Q000379:methods*; D012909:Snake Bites / Q000628:therapy; D012910:Snake Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D012911:Snakes
D000997:Antivenins; D012910:Snake Venoms