[Autoantibodies to thyroid gland antigens in chronic relapsing urticaria].
The content of total IgE, antibodies to thyroglobulin (TG-Ab), antibodies to thyreoid peroxidase (TPO-Ab) in the blood serum and skin reaction to autologous serum were detected in patients with chronic relapsing urticaria (CRU). The skin test to autologous serum yielded positive results in 42% of the patients. The elevated levels of TG-Ab and TPO-Ab were detected in 30.7% and 35.4% of the patients, the elevated level of total IgE was detected in 60% of the patients. At the same time the detection rates of antithyreoid antibodies and the elevated level of IgE were not linked with skin reaction to autologous serum. Apparently, in addition to autoantibodies to IgE or its receptor (the positive skin test to autologous serum), thyroid gland antibodies may take part in the mechanism of the CRU formation.
Sibgatulina
N A
NA
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Kuz'mina
N S
NS
Rakhmatullina
N M
NM
Gevarzieva
V B
VB
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012882:Skin Tests; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D014581:Urticaria / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D007073:Immunoglobulin E; D013954:Thyroglobulin; D007453:Iodide Peroxidase