Cell polarity: Par6, aPKC and cytoskeletal crosstalk.
Par6 and atypical protein kinase C are key players in the establishment of cell polarity. First discovered in Caenorhabditis elegans, the function of this protein complex is conserved in all multicellular organisms. Recent work is beginning to throw light on how it converts information generated by extracellular cues into intracellular asymmetry.
Etienne-Manneville
Sandrine
S
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Hall
Alan
A
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism / Q000648:ultrastructure; D046911:Macromolecular Substances; D011493:Protein Kinase C / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D046911:Macromolecular Substances; D011506:Proteins; C512642:par-6 protein, C elegans; C115015:PKC-3 protein; D011493:Protein Kinase C