Diversifying neural cells through order of birth and asymmetry of division.
A key question in developmental neurobiology is how the diversity of cell types that make up the mature nervous system are generated from a common set of progenitor cells. Drosophila genes governing temporal cell fate determination and asymmetric cell divisions involving numb may represent evolutionarily conserved mechanisms for regulating cell fate diversification in the developing nervous system.
Zhong
Weimin
W
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. weimin.zhong@yale.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009420:Nervous System / Q000166:cytology / Q000196:embryology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007605:Juvenile Hormones; D009419:Nerve Tissue Proteins; C106292:Numbl protein, mouse; C060606:numb protein, Drosophila