Leukocytoclastic-vasculitic neuropathy associated with chronic Epstein-Barr virus infection.
We report a patient with leukocytoclastic-vasculitic neuropathy associated with chronic Epstein-Barr virus (EBV) infection. A 55-year-old man had been suffering from chronic progressive axonal polyneuropathy and skin erythema for 3 years. A skin biopsy showed capillary vasculitis with clustered leukocyte fragments. Findings of serum assays, a polymerase chain reaction for EBV-DNA, and in situ hybridization indicated chronic EBV infection. Immunosuppressive treatment resulted in the gradual lessening of his general and neurologic symptoms.
Kanai
Kazuaki
K
Department of Neurology, Chiba University School of Medicine, Chiba, Japan.
Kuwabara
Satoshi
S
Mori
Masahiro
M
Arai
Kimihito
K
Yamamoto
Takako
T
Hattori
Takamichi
T
D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D011115:Polyneuropathies / Q000473:pathology / Q000821:virology*; D013497:Sural Nerve / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000473:pathology / Q000821:virology*