title: Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors.
authors.affiliation: University of Essen, West German Cancer Center, Essen, Germany. dirk.strumberg@uni-essen.de
authors.forename: D
authors.initials: D
authors.lastname: Strumberg
authors.forename: D
authors.initials: D
authors.lastname: Voliotis
authors.forename: J G
authors.initials: JG
authors.lastname: Moeller
authors.forename: R A
authors.initials: RA
authors.lastname: Hilger
authors.forename: H
authors.initials: H
authors.lastname: Richly
authors.forename: S
authors.initials: S
authors.lastname: Kredtke
authors.forename: C
authors.initials: C
authors.lastname: Beling
authors.forename: M E
authors.initials: ME
authors.lastname: Scheulen
authors.forename: S
authors.initials: S
authors.lastname: Seeber
mesh_terms: D001557:Benzenesulfonates / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D020714:Maximum Tolerated Dose; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D010766:Phosphorylation; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011725:Pyridines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077157:Sorafenib
chemical_list: D001557:Benzenesulfonates; D004791:Enzyme Inhibitors; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib; D019908:Proto-Oncogene Proteins c-raf; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases