[Assessment of variables relative to prethrombotic state after operation in patients with gynecological malignancies].
OBJECTIVE
To study the changes in the variables in patients with gynecological malignancies after operation.


METHODS
Platelet alphagranule membrane protein (GMP-140), von Willebrand Factor (vWF), antithrombin III activity (AT-III), protein C-dependent partial thromboplastin activation time, plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI), D-Dimer were examined in 20 normal non-pregnant women and 38 patients after operation with gynecological malignancies.


RESULTS
vWF, GMP-140, PLG, D-Dimer, and PAI of patients with malignancies before operation were obviously higher than those of the healthy women (P<0.01). After operation the parameters were obviously elevated in the patients (P<0.01). AT-III and partial thromboplastin activation time were significantly reduced in comparison with the healthy subjects (P<0.01). t-PA showed no significant difference between the groups (P>0.05).


CONCLUSIONS
Obvious prethrombotic state characterizes the patients with gynecological malignancies after operation.
Liu
Bao-ying
BY
Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Zhong
Mei
M
Yu
Yan-hong
YH
Li
Jing-shan
JS
Zheng
Lei
L
Wang
Qian
Q
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D005833:Genital Neoplasms, Female / Q000097:blood / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D020246:Venous Thrombosis / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
D019007:P-Selectin; D014841:von Willebrand Factor; D000990:Antithrombin III