title: Cough receptor sensitivity to capsaicin does not change after allergen bronchoprovocation in allergic asthma.
abstract: BACKGROUND
  The relationship between cough receptor sensitivity and eosinophilic inflammation of the airway in patients with asthma remains unclear.
  
  
  METHODS
  Eighteen patients with asthma sensitised to house dust mite (HDM) were enrolled in a randomised parallel group study. Patients with asthma whose main symptom was cough were not enrolled in the study. Half the patients were randomly assigned to inhale saline and the other half to inhale HDM allergen. Cough receptor sensitivity to capsaicin, airway responsiveness to histamine, and sputum eosinophils analysed with hypertonic saline inhalation were investigated before and 24 hours after saline or HDM allergen bronchoprovocation.
  
  
  RESULTS
  Patients inhaling saline showed no significant changes in sputum eosinophils (from 7.87% (95% confidence interval (CI) 5.08 to 12.19) to 8.60% (95% CI 3.03 to 14.18); p=0.97), airway responsiveness to histamine (from 726.68 micro g/ml (95% CI 251.90 to 2096.36) to 773.01 micro g/ml (95% CI 251.36 to 2377.23); p=0.96), or capsaicin sensitivity (from 7.23 micro M (95% CI 2.45 to 21.31) to 7.24 micro M (95% CI 2.46 to 21.31); p=0.96). Early asthmatic response was induced in all patients, and late asthmatic response was observed in six of nine patients inhaling HDM allergen. Although there were significant increases in sputum eosinophils (from 9.83% (95% CI 6.78 to 14.27) to 21.00% (95% CI 13.85 to 28.15); p<0.01) and airway responsiveness to histamine (from 784.16 micro g/ml (95% CI 318.24 to 1932.24) to 377.81 micro g/ml (95% CI 118.43 to 1205.24); p<0.05) 24 hours after HDM allergen inhalation compared with baseline levels, capsaicin sensitivity did not change significantly (from 5.75 micro M (95% CI 1.91 to 17.30) to 6.20 micro M (95% CI 2.21 to 17.38); p=0.77).
  
  
  CONCLUSIONS
  These findings suggest that cough receptor sensitivity to capsaicin is not associated with eosinophilic inflammation of the airway in patients with allergic asthma whose main symptoms are wheezing and dyspnoea but not cough.
authors.affiliation: First Department of Internal Medicine, Showa University, Tokyo, Japan. minochan@fn.catv.ne.jp
authors.forename: H
authors.initials: H
authors.lastname: Minoguchi
authors.forename: K
authors.initials: K
authors.lastname: Minoguchi
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: N
authors.initials: N
authors.lastname: Kihara
authors.forename: M
authors.initials: M
authors.lastname: Adachi
mesh_terms: D000328:Adult; D000485:Allergens / Q000494:pharmacology; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000502:physiology; D001985:Bronchial Provocation Tests; D001991:Bronchitis / Q000503:physiopathology; D002211:Capsaicin; D003371:Cough / Q000503:physiopathology; D004391:Dust; D004804:Eosinophils / Q000502:physiology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D011984:Sensory Receptor Cells / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology; D013183:Sputum / Q000166:cytology; D014797:Vital Capacity / Q000502:physiology
chemical_list: D000485:Allergens; D004391:Dust; D012965:Sodium Chloride; D002211:Capsaicin