The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze.
The effect of (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a 5-HT(1A) receptor agonist, on mouse behavior was examined in the elevated plus-maze. MKC-242 significantly increased the percentage of open-arm entries and the percentage of open-arm time, indices of anxiety reduction, while it did not increase the enclosed-arm entries and time spent in enclosed arms. The effect of MKC-242 was antagonized by a low dose of the 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide which alone did not affect the behavior. These findings suggest that MKC-242 increases the exploratory activity of mice in the elevated plus-maze via activation of 5-HT(1A) receptors, probably the presynaptic autoreceptors.
Sakaue
Masaki
M
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871, Osaka, Japan.
Ago
Yukio
Y
Sowa
Chikako
C
Koyama
Yutaka
Y
Baba
Akemichi
A
Matsuda
Toshio
T
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D004146:Dioxanes; D004149:Dioxoles; D010879:Piperazines; D011725:Pyridines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; C096294:osemozotan; D003975:Diazepam