title: After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.
abstract: Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic marginal zone is essential in the initiation of an immune response to encapsulated bacteria. In this study, we analysed the effects of three different cytostatic agents on humoral immune responses. We found a reduced, but detectable immune response capacity at two days after treatment although the marginal zone B cell population is severely reduced at this time point. Twenty-four days after cessation of treatment, the immune response capacity was largely restored although lymphoid compartments were still not completely restored at that time point. Apparently, the presence of only few marginal zone B cells is sufficient to evoke a rise in antibody titres and although antibody titre increases are low, even small rises are most likely clinically relevant.
authors.affiliation: Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands. j.h.zandvoort@path.azg.nl
authors.forename: A
authors.initials: A
authors.lastname: Zandvoort
authors.forename: M E
authors.initials: ME
authors.lastname: Lodewijk
authors.forename: P A
authors.initials: PA
authors.lastname: Klok
authors.forename: M A
authors.initials: MA
authors.lastname: Breukels
authors.forename: G T
authors.initials: GT
authors.lastname: Rijkers
authors.forename: W
authors.initials: W
authors.lastname: Timens
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000942:Antigens, Bacterial / Q000097:blood / Q000276:immunology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology*; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology; D013290:Streptococcal Infections / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D000970:Antineoplastic Agents; D022242:Pneumococcal Vaccines