title: In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs.
abstract: We evaluated 117 isolates of Mycobacterium tuberculosis for susceptibility to linezolid by the proportion and E-test methods. Linezolid showed high in vitro activity, with all the strains inhibited by <or=1 microg of the drug per ml. E-test MICs were at least 4 dilutions lower than their equivalents by the standard proportion method.
authors.affiliation: Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Alcalá
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Ruiz-Serrano
authors.forename: Cristina
authors.initials: C
authors.lastname: Pérez-Fernández Turégano
authors.forename: Darío
authors.initials: D
authors.lastname: García De Viedma
authors.forename: Marisol
authors.initials: M
authors.lastname: Díaz-Infantes
authors.forename: Mercedes
authors.initials: M
authors.lastname: Marín-Arriaza
authors.forename: Emilio
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D023303:Oxazolidinones / Q000494:pharmacology*; D018088:Tuberculosis, Multidrug-Resistant
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid