Body mass index and incidence of dementia: the PAQUID study.
To study the relationship between body mass index (BMI) and risk of dementia, a cohort of 3,646 individuals aged > or =65 years living at home and without cognitive disorders at baseline were followed up for 8 years (the PAQUID [Personnes Agées Quid] Study). Subjects with a BMI < 21 had an increased risk of developing dementia as compared with subjects whose BMI was between 23 and 26 (odds ratio = 1.48, 95% CI = 1.08 to 2.04). However, when individuals who developed dementia early during the follow-up were excluded from the analysis, this relationship was no longer significant. A low BMI does not in itself seem to be a risk factor for dementia.
Nourhashémi
F
F
Service de Médecine Interne et de Gérontologie Clinique, CHU Purpan-Casselardit, Toulouse, France. Fatinour@aol.com
Deschamps
V
V
Larrieu
S
S
Letenneur
L
L
Dartigues
J-F
JF
Barberger-Gateau
P
P
D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D016017:Odds Ratio; D016016:Proportional Hazards Models; D012306:Risk; D018570:Risk Assessment; D012307:Risk Factors; D013851:Thinness / Q000453:epidemiology