title: Incorporation of 8-histaminyl-deoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2'-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling.
abstract: The 3'phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed.
authors.affiliation: Department of Chemistry, 2036 Main Mall, 6174 University Blvd, University of British Columbia, Vancouver, B. C., V6T-1Z1 Canada.
authors.forename: Leonard
authors.initials: L
authors.lastname: Lermer
authors.forename: John
authors.initials: J
authors.lastname: Hobbs
authors.forename: David M
authors.initials: DM
authors.lastname: Perrin
mesh_terms: D000818:Animals; D020029:Base Pairing; D001483:Base Sequence; D021881:DNA, Catalytic / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D006632:Histamine / Q000031:analogs & derivatives*; D007093:Imidazoles / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D021881:DNA, Catalytic; D003839:Deoxyadenosines; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D006632:Histamine