How will we know a lapse when we see one? Comment on Leri and Stewart (2002).
The article by F. Leri and J. Stewart (2002) addresses the validity of animal models of relapse in a more sophisticated manner than does much prior research. These researchers have shown that drug self-administration can be influenced by the presence of drug contingent cues as well as by active self-administration versus passive infusion of "lapse" doses. This research also leads to additional questions about the external validity of animal relapse models. Current relapse models may lack validity because of the parameters of drug exposure, because abstinence is imposed on the organism, and because there is no motivational influence that counters resumption of drug self-administration. F. Leri and J. Stewart's (2002) article encourages a more thorough assessment of the motivational context of relapse models.
Baker
Timothy B
TB
Center for Tobacco Research and Intervention, University of Wisconsin-Madison, 53711, USA. tbb@ctri.medicine.wisc.edu
Curtin
John J
JJ
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D005108:Extinction, Psychological; D003932:Heroin / Q000494:pharmacology*; D006556:Heroin Dependence / Q000517:prevention & control; D006801:Humans; D023421:Models, Animal; D009042:Motivation; D051381:Rats; D012054:Reinforcement, Psychology; D015203:Reproducibility of Results
D003932:Heroin