[Effect of anticancer polypeptide from Buthus Martensii venom on immune function in the H22-bearing mice].
OBJECTIVE
To observe the effect of anticancer polypeptide from Buthus Martensii Venom (APBMV) on Immune function in the H22-bearing mice.


METHODS
The MTT colorimetric method, homolysin assay, lymphocyte transformation test, delayed hypersensitivity assay and WBC-count of peripheral blood were used in this study.


RESULTS
APBMV could obviously augment NK activity, promote proliferation of lymphocytes induced by Con A, potentiate the response of DTH induced by DNCB, antagonize the decrease of WBC in peripheral blood induced by 5-Fu in the H22-bearing mice.


CONCLUSIONS
APBMV can obviously increase immune function in the H22-bearing mice and antagonize hypoimmunity immunodeficiency or immunodeficiency induced by chemotherapy or the tumor.
Yang
J B
JB
Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi, China.
Li
X W
XW
Dong
W H
WH
Kong
T H
TH
Song
H X
HX
Zheng
X Y
XY
Liu
G T
GT
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D012604:Scorpion Venoms / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008419:Materia Medica; D012604:Scorpion Venoms