Clinical implications of the oral manifestations of HIV infection in children.
The authors hypothesized that patients infected with HIV at birth would be more vulnerable to oral diseases such as periodontal disease and caries because of their compromised immune system. As a result, they designed a 3-year, longitudinal, case-controlled study that examined HIV-infected children as compared with their normal noninfected household peers. Over 100 HIV-infected participants ages 2 to 15 years were examined at 6-month intervals; no differences were found with respect to caries or periodontal disease prevalence and incidence when the two groups were compared. Although the level of oral disease was similar in the two groups, both groups had more caries than the national norm. Thus, failure to use a control group would have led to the erroneous conclusion that children with HIV infection had a high level of caries. In addition, the authors discovered that tooth eruption was delayed in the HIV-infected group, suggesting some developmental impediment. The HIV-infected group also showed more oral lesions that included candidiasis, linear gingival erythema, and medial rhomboid glossitis. Overall, oral lesions were not valid predictors of the serious consequences of AIDS. The authors speculated, however, that examinations at intervals more frequent than every 6 months might be required to determine whether oral lesions can predict frank AIDS and lowered CD4 cell counts.
Fine
Daniel H
DH
Dental Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Health Sciences Building, Room C-636, 185 South Orange Avenue, Newark, NJ 07103, USA. finedh@umdnj.edu
Tofsky
Nanci
N
Nelson
Evelyn M
EM
Schoen
Diane
D
Barasch
Andre
A
D000293:Adolescent; D017677:Age Distribution; D002177:Candidiasis / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004245:DMF Index; D003731:Dental Caries / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology*; D009061:Mouth Mucosa / Q000473:pathology; D010510:Periodontal Diseases / Q000453:epidemiology; D015995:Prevalence; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology