title: Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.
abstract: OBJECTIVE
  To evaluate the association between leiomyomas and estrogen receptor gene polymorphism.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of gynecology and genetics.
  
  
  METHODS
  Women with (n = 159) or without leiomyomas (n = 131).
  
  
  METHODS
  Polymerase chain reaction was used to detect dinucleotide (thymine-adenine [TA]) repeat polymorphisms upstream of the estrogen receptor gene. Genotypes were classified as A through P according to the number of the TA repeats from 12 to 27. Distributions of TA repeat for estrogen receptor in both groups were compared.
  
  
  RESULTS
  Genotypes A to E were detected in 10.7%, 18.9%, 15.7%, 16.4%, and 4.4%, respectively, of women with leiomyomas and 4.2%, 9.5%, 20.6%, 19.1%, and 10.3% of women without leiomyomas. Women with genotypes A and B (12 or 13 TA repeats) have a higher risk for leiomyomas, and those with genotype E (16 TA repeats) have a lower risk.
  
  
  CONCLUSIONS
  Estrogen receptor gene polymorphism probably contributes to the pathogenesis of leiomyoma and may predict the susceptibility to leiomyoma. The 12 and 13 TA repeats are associated with a higher risk of leiomyoma.
authors.affiliation: Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
authors.forename: Yao-Yuan
authors.initials: YY
authors.lastname: Hsieh
authors.forename: Chi-Chen
authors.initials: CC
authors.lastname: Chang
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Horng-Der
authors.initials: HD
authors.lastname: Tsai
authors.forename: Lian-Shun
authors.initials: LS
authors.lastname: Yeh
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
mesh_terms: D000225:Adenine; D018900:Dinucleotide Repeats; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*; D013941:Thymine; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: D011960:Receptors, Estrogen; D000225:Adenine; D013941:Thymine