title: Effect of adrenalectomy on rat epididymidis.
abstract: OBJECTIVE
  To investigate the effect of adrenalectomy (ADX) on the epididymidis of Sprague-Dawley rats.
  
  
  METHODS
  The histological, biochemical (cholesterol protein, zinc, copper, alkaline and acid phosphatase aryl sulphatase, lactic dehydrogenase and leucine amino peptidase) and hormonal (FSH, LH and testosterone) changes of caput and cauda epididymis in ADX rats were observed.
  
  
  RESULTS
  Organ wet weight, histological studies and morphometric measurements indicated a cellular degeneration in caput and cauda epididymis of ADX rats. Serum testosterone level was significantly lower in ADX than in sham-operated rats, while the serum FSH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham-operated rats. Epididymal zinc level increased whereas copper level decreased in ADX rats compared to the sham-operated.
  
  
  CONCLUSIONS
  Adrenalectomy leads to degeneration of caput and cauda epididymidis epithelial cells as a result of decreased supply of testosterone.
authors.affiliation: Cell Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur - 302 004, India. fasilec@eth.net
authors.forename: Neena
authors.initials: N
authors.lastname: Nair
authors.forename: R S
authors.initials: RS
authors.lastname: Bedwal
authors.forename: R S
authors.initials: RS
authors.lastname: Mathur
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000315:Adrenalectomy; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004822:Epididymis / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D015032:Zinc / Q000378:metabolism
chemical_list: D013739:Testosterone; D003300:Copper; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D001192:Arylsulfatases; D007931:Leucyl Aminopeptidase; D015032:Zinc