title: Translocation Down syndrome.
abstract: Cytogenetic investigations carried on 1021 cases of Down syndrome revealed translocation in 46 cases. The most frequent was of t(14;21) and t(21;21) types. Most of the translocation DS cases (n = 31) were born to younger mother's (< 25 years), when compared to pure trisomy 21 DS cases. Parental karyotypes, family history and parental ages has helped us greatly in offering genetic counseling, prenatal diagnosis and estimating the risk for the next conception.
authors.affiliation: Inst. of Immunohematology, Mumbai.
authors.forename: A
authors.initials: A
authors.lastname: Jyothy
authors.forename: G N Mallikarjuna
authors.initials: GN
authors.lastname: Rao
authors.forename: K S D
authors.initials: KS
authors.lastname: Kumar
authors.forename: V Babu
authors.initials: VB
authors.lastname: Rao
authors.forename: B Uma
authors.initials: BU
authors.lastname: Devi
authors.forename: P P
authors.initials: PP
authors.lastname: Reddy
mesh_terms: D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008423:Maternal Age; D010331:Paternal Age; D018566:Pregnancy, High-Risk; D014178:Translocation, Genetic