title: Prevalence of prostatic intra-epithelial neoplasia (PIN) in biopsies from hospital practice and pilot screening: clinical implications.
abstract: As high grade PIN is commonly associated with concomitant cancer, current literature recommends re-biopsy of patients with high grade PIN. This paper describes the prevalence of high grade prostatic intra-epithelial neoplasia (PIN) from three independent clinical settings, reported by a single pathologist (MCP). High grade PIN was diagnosed in biopsies from 131 of the 1205 (11%) of patients in whom cancer was suspected in hospital practice, 42 of the 202 (20%) asymptomatic men screened for prostate cancer and 29 of the 118 (25%) patients presenting with prostatism in a case finding study. Re-biopsy on this scale has major clinical and cost implications. However, from a literature review, there is evidence to suggest that the risk of concomitant cancer with high grade PIN may be stratified according to serum PSA. This opinion should be tested prospectively.
authors.affiliation: St Bartholomew's Hospital, London.
authors.forename: M R
authors.initials: MR
authors.lastname: Feneley
authors.forename: J S A
authors.initials: JS
authors.lastname: Green
authors.forename: M P A
authors.initials: MP
authors.lastname: Young
authors.forename: P
authors.initials: P
authors.lastname: Bose
authors.forename: R S
authors.initials: RS
authors.lastname: Kirby
authors.forename: W B
authors.initials: WB
authors.lastname: Peeling
authors.forename: M C
authors.initials: MC
authors.lastname: Parkinson