In vitro anti-anaerobic activity of the cephalosporin derivative RWJ 54428, compared to seven other compounds.
Agar dilution MIC was used to test the activity of RWJ 54428, a new cephalosporin derivative, compared to imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin and metronidazole against 363 anaerobes isolated from clinical specimens. RWJ 54428 had low MICs against most beta-lactamase-negative Gram-negative rods, and all Gram-positive strains except Clostridium difficile. Imipenem and meropenem had the lowest MICs (MIC50s of 0.125 mg/L and MIC90s of 1.0 mg/L). Piperacillin-tazobactam, clindamycin and metronidazole were active against most strains, and ceftriaxone was active mainly against beta-lactamase-negative organisms.
Hoellman
D B
DB
Department of Pathology, Hershey Medical Center, PO Box 850, PA 17033, USA.
Kelly
L M
LM
Jacobs
M R
MR
Appelbaum
P C
PC
D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000254:growth & development; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D002511:Cephalosporins; C420727:RWJ 54428