Design of lattice proteins with explicit solvent.
Protein design is important to develop new drugs. As such, a knowledge of the correct model to use to design novel proteins is of the utmost importance. Here we show that a simple model where the solvent degrees of freedom are (semi)explicitly taken into account performs better than other existing models when compared to real data. Some consequences on the criteria to be used for protein design are discussed.
Salvi
G
G
Institut de Physique Théorique, Université de Lausanne, CH-1015 Lausanne, Switzerland.
Mölbert
S
S
De Los Rios
P
P