Techniques: fruit flies as models for neuropharmacological research.
An unlikely animal model is gaining popularity in neuropharmacological research: the 2-mm fruit fly (Drosophila melanogaster). Drugs have been administered to adult flies in their food and, more recently, via gasses and injections. Pharmacological tools have introduced behavioral alterations in Drosophila reminiscent of human behavior, rescued flies from gene-alteration-triggered neuropathologies, and triggered gene silencing. Combined, these methods hold promise for significant neuropharmacological advancement.
Manev
Hari
H
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA. hmanev@psych.uic.edu
Dimitrijevic
Nikola
N
Dzitoyeva
Svetlana
S
D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009480:Neuropharmacology / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
D004364:Pharmaceutical Preparations