[Study on improving the dissolution rate of tanshinone in vitro by solvent deposition method].
OBJECTIVE
To improve the dissolution rate of a poorly watersoluble drug, tanshinone.


METHODS
Using pregeletinged starch as carrier, to prepare solvent deposition systems of tanshinone solvent method. The dissolution rate of tanshinone, solvent deposition systems and physical mixture were detected, and the physico-chemical properties of these study forms were investigated with scanning electron microscopy and infrared spectroscopy.


RESULTS
The dissolution rate of tanshinone from the solvent deposition systems in vitro was significantly higher than that from physical mixtures and tanshinone powered alone. Tanshinone deposited on the surface of the carrier in crystal form, and the size was obviously reduced. A lot of acerose crystals of tanshinone on the surface of the carrier occurred. No chemical reaction acted between tanshinone and carrier.


CONCLUSIONS
The dissolution rate of tanshinone in vitro can be improved with solvent deposition method.
Chu
M Q
MQ
Institute of Chemistry and Pharmacy, East China University of Science and Technology, Shanghai 200237.
Gu
H C
HC
Liu
G J
GJ
D045784:Abietanes; D004337:Drug Carriers; D010616:Phenanthrenes / Q000008:administration & dosage*; D011208:Powders; D012995:Solubility; D013213:Starch
D045784:Abietanes; D004337:Drug Carriers; D010616:Phenanthrenes; D011208:Powders; C021751:tanshinone; D013213:Starch