A facile solution phase combinatorial synthesis of tetrasubstituted pyridines using the Bohlmann-Rahtz heteroannulation reaction.
The solution phase combinatorial Bohlmann-Rahtz reaction gives highly functionalized pyridine libraries from enamino esters and alkynones in a single synthetic step. Good product ratios and library purities were obtained in reactions catalyzed by zinc(II) bromide, the acid-catalyzed heteroannulation procedure offering considerable improvements over traditional methodology.
Bagley
Mark C
MC
Department of Chemistry, Cardiff University, P.O. Box 912, Cardiff, CF10 3TB, United Kingdom. bagleymc@cf.ac.uk
Dale
James W
JW
Ohnesorge
Maren
M
Xiong
Xin
X
Bower
Justin
J