Chemoembolization for hepatic metastases.
Liver metastases are one of the most difficult therapeutic challenges in modern oncologic practice. Few systemic therapies are effective for solid tumors in the liver. Resection is possible in a minority of patients and usually not curative. Image-guided therapies such as chemoembolization offer substantial intensification of treatment by combining tumor ischemia, increased drug concentrations, prolonged dwell time, and reduced systemic toxicity. Although not a curative therapy, durable responses are seen in most adenocarcinomas, which may contribute to prolongation and preservation of quality of life by delaying liver failure in patients with liver-dominant disease.
Gee
Michael
M
Division of Interventional Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Soulen
Michael C
MC
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D018278:Carcinoma, Neuroendocrine / Q000556:secondary / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy*; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D018579:Patient Selection; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed