title: Precocious puberty: an endocrine manifestation in congenital toxoplasmosis.
abstract: We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH. Three of them showed low GH response to an insulin tolerance test. All the children had severe mental retardation. We emphasize that children with congenital toxoplasmosis should have their hypothalamopituitary function evaluated even in subclinical situations that could be responsible for endocrinological disturbances such as precocious puberty.
authors.affiliation: Pediatric Endocrinology Unit, Instituto da Criança Hospital das Clinicas, São Paulo University School of Medicine, Brazil.
authors.forename: Nuvarte
authors.initials: N
authors.lastname: Setian
authors.forename: Regina S F
authors.initials: RS
authors.lastname: Andrade
authors.forename: Hilton
authors.initials: H
authors.lastname: Kuperman
authors.forename: Thais Della
authors.initials: TD
authors.lastname: Manna
authors.forename: Vaê
authors.initials: V
authors.lastname: Dichtchekenian
authors.forename: Durval
authors.initials: D
authors.lastname: Damiani
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008572:Menarche; D011629:Puberty, Precocious / Q000209:etiology*; D012189:Retrospective Studies; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000503:physiopathology
chemical_list: D007986:Luteinizing Hormone