title: Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase.
abstract: This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase were investigated. Compounds at a concentration of 500 microM exhibited 33.4-62.1% of inhibition on dopa oxidase activity of mushroom tyrosinase. Their inhibitory effects were higher than that of kojic acid (31.7%), a well known tyrosinase inhibitor. 2-(4-Methylphenyl)-1,3-selenazol-4-one (A) exhibited the strongest inhibitory effect among them dose-dependently and in competitive inhibition manner.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gifu University, Seoul, Korea.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Koketsu
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Choi
authors.forename: Hideharu
authors.initials: H
authors.lastname: Ishihara
authors.forename: Beong Ou
authors.initials: BO
authors.lastname: Lim
authors.forename: Hocheol
authors.initials: H
authors.lastname: Kim
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C474089:2-(4-Methylphenyl)-1,3-selenazol-4-one; D001393:Azoles; D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; D011753:Pyrones; C011890:kojic acid; D014442:Monophenol Monooxygenase