Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships.
A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50-100 times greater antitumor activities than the commercial product, Cisplatin.
Hwang
Ki-Jun
KJ
Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University, Dukjindong 664-14 Chonju 561-756, Korea. kijun@moak.chonbuk.ac.kr
Park
Kyung-Ho
KH
Lee
Chong-Ock
CO
Kim
Beom-Tae
BT
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001565:Benzoates; D010671:Phenylurea Compounds; D011720:Pyrazoles