title: [Genome shift of hepatitis E virus in Asia].
abstract: Dideoxy chain termination method was applied to sequence hepatitis E virus structure gene of Asia isolates, cDNA sequence and amino acid residues were determined. The results showed that among Asia countries: Indian, Burma, China, Pakistan and Kirghiz Republic, Hepatitis E virus genome shifted within the range of 5% and amino acid residues shifted within 1% compared with Mexico isolate. Asia Hepatitis E virus isolates have limited genome shift, which suggests recombinant Hepatitis E vaccine based on Asia HEV gene might protect all HEV infection in this area.
authors.affiliation: Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052.
authors.forename: S
authors.initials: S
authors.lastname: Bi
authors.forename: H
authors.initials: H
authors.lastname: Zhuang
authors.forename: C
authors.initials: C
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D001208:Asia; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics*; D016679:Genome, Viral; D016752:Hepatitis E virus / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D004279:DNA, Viral; D015678:Viral Structural Proteins