title: Pleomorphic lipoma of the orbit: a case series and review of literature.
abstract: OBJECTIVE
  Pleomorphic lipomas are rare benign tumors that can resemble a variety of malignant soft tissue tumors on histologic examination. Six cases of patients with orbital pleomorphic lipoma, one of which was proven to be bilateral, are presented.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series with clinicopathologic correlation.
  
  
  METHODS
  Clinical and histologic review of 6 patients with pleomorphic lipomas of the orbit and histologic review of fat from 22 exenteration specimens and 20 other orbital procedures.
  
  
  METHODS
  Evidence of histologic abnormalities in histologic specimens.
  
  
  RESULTS
  Pleomorphic spindle cells and multinucleated cells with nuclei arranged in a floret-like pattern were present in 7 specimens from 6 patients presenting with a clinical diagnosis of orbital fat prolapse, but there were no similar cell types present in the adipose tissue of 22 exenteration or 20 other orbital specimens.
  
  
  CONCLUSIONS
  Pleomorphic lipoma may arise in the orbit, presenting as what was hitherto considered to be age-related epibulbar prolapse of orbital fat.
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom.
authors.forename: Claire S
authors.initials: CS
authors.lastname: Daniel
authors.forename: Michele
authors.initials: M
authors.lastname: Beaconsfield
authors.forename: Geoff E
authors.initials: GE
authors.lastname: Rose
authors.forename: Phil J
authors.initials: PJ
authors.lastname: Luthert
authors.forename: J Godfrey
authors.initials: JG
authors.lastname: Heathcote
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Clark
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008067:Lipoma / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies