title: Molecular etiology of gut malformations and diseases.
abstract: This review describes recent advances using animal models in the analysis of the molecular controls of gastrointestinal development, with specific attention to mutations causing maldevelopment similar to those seen in human gut malformations. By focusing on specific human gut pathologic conditions and maldevelopment, we describe the probable roles of signaling pathways, including the hedgehog pathway, the bone morphogenic protein pathway, and the role of the homeotic genes.
authors.affiliation: Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: de Santa Barbara
authors.forename: Gijs Robert
authors.initials: GR
authors.lastname: van den Brink
authors.forename: Drucilla Jane
authors.initials: DJ
authors.lastname: Roberts
mesh_terms: D000818:Animals; D004064:Digestive System / Q000196:embryology / Q000294:innervation; D004065:Digestive System Abnormalities; D004195:Disease Models, Animal; D017615:Enteric Nervous System; D005767:Gastrointestinal Diseases / Q000196:embryology / Q000209:etiology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D006801:Humans; D009024:Morphogenesis; D015534:Trans-Activators
chemical_list: D053823:Hedgehog Proteins; D015534:Trans-Activators