Macrocephaly and epidural involvement of T-cell acute lymphoblastic leukemia.
We describe a 2-year-old female who presented with macrocephaly and anemia. Magnetic resonance imaging revealed a diffusely enhancing epidural lesion over the sagittal frontoparietal region. Bone marrow examination confirmed the diagnosis of T-cell acute lymphoblastic leukemia. Induction chemotherapy led to hematologic remission and neuroimaging resolution of the mass. This report suggested macrocephaly could be a rare and early manifestation of leukemia in children.
Jaing
Tang Her
TH
Hematology/Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan.
Hung
Po Cheng
PC
Hung
Iou Jih
IJ
Wang
Huei Shyong
HS
Wang
Chao Jan
CJ
D000740:Anemia / Q000209:etiology; D001856:Bone Marrow Examination; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004824:Epidural Space / Q000473:pathology*; D006257:Head / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D017254:Leukemic Infiltration / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D012074:Remission Induction