Antidote review: fomepizole for methanol poisoning.
Fomepizole (Antizol) was recently approved by the US Food and Drug Administration for treatment of methanol poisoning. By inhibiting the hepatic enzyme alcohol dehydrogenase, it presents formation of toxic metabolites with far fewer consequences than traditional ethanol therapy. It appears that fomepizole will become standard therapy for methanol intoxication as it is for ethylene glycol poisoning.
Mycyk
Mark B
MB
Division of Occupational and Environmental Medicine, Toxikon Consortium, Cook County Hospital, Chicago, USA.
Leikin
Jerrold B
JB
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000931:Antidotes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077604:Fomepizole; D006801:Humans; D000432:Methanol / Q000097:blood / Q000506:poisoning*; D011720:Pyrazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D000426:Alcohol Dehydrogenase; D000432:Methanol