The influence of HLA genotype on AIDS.
Genetic resistance to infectious diseases is likely to involve a complex array of immune-response and other genes with variants that impose subtle but significant consequences on gene expression or protein function. We have gained considerable insight into the genetic determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this regard. Numerous reports have identified a role for HLA genotype in AIDS outcomes, implicating many HLA alleles in various aspects of HIV disease. Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition.
Carrington
Mary
M
Basic Research Program, SAIC-Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA. carringt@ncifcrf.gov
O'Brien
Stephen J
SJ
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology; D000483:Alleles; D018450:Disease Progression; D005802:Genes, MHC Class II / Q000235:genetics; D005838:Genotype; D015497:HIV-1 / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II