RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer.
Covalent modification of proteins with ubiquitin regulates almost all aspects of eukaryotic cellular function. Ubiquitin protein ligases (E3s) play central regulatory roles in that they provide substrate specificity to this process and therefore, represent attractive molecular targets for disease therapy. We summarize recent advances in our understanding of RING finger and RING finger-related E3s with emphasis on BRCA1 and the tumor autocrine motility factor receptor (gp78), as well as discuss the potential for components of the ubiquitin pathway for proteasomal degradation as molecular targets.
Fang
Shengyun
S
Regulation of Protein Function Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 22-95, 1050 Boyles Street, Frederick, MD 21702, USA.
Lorick
Kevin L
KL
Jensen
Jane P
JP
Weissman
Allan M
AM
D020816:Amino Acid Motifs; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008025:Ligases / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D060285:Receptors, Autocrine Motility Factor; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases
D019313:BRCA1 Protein; D018121:Receptors, Cytokine; C555000:AMFR protein, human; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases; D008025:Ligases