AIDS-related malignancies.
Immunodeficiency alters the risk of cancer. Specific types of immune dysfunction are associated with different tumor risks, but most tumors are related to oncogenic viruses. In acquired immunodeficiency due to the human immunodeficiency virus (HIV), HIV itself rarely directly causes cancer; rather, it provides the immunologic background against which other viruses can escape immune control and induce tumors. The most common malignancies are Kaposi's sarcoma and non-Hodgkin's lymphoma. This chapter discusses the pathophysiologic background of these tumors, how they have been affected by the use of anti-HIV medications, and their clinical management.
Scadden
David T
DT
AIDS Research Center and Cancer Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 5212, Boston, Massachussetts 02129, USA. scadden.david@mgh.harvard.edu
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy; D023241:Antiretroviral Therapy, Highly Active; D004854:Herpesvirus 4, Human / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000276:immunology* / Q000628:therapy; D030361:Papillomavirus Infections / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000276:immunology* / Q000628:therapy; D012878:Skin Neoplasms / Q000276:immunology* / Q000628:therapy; D019139:Tumor Escape / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000628:therapy