title: Dopaminergic effects after chronic treatment with nandrolone visualized in rat brain by positron emission tomography.
abstract: Anabolic-androgenic steroids (AAS) have recently been shown to induce neurochemical alterations in areas of the male rat CNS related to behavioural changes that have been observed among AAS misusers. In the present study, positron emission tomography (PET) is suggested as a suitable in vivo method in order to visualize the density of the dopamine transporter ([11C]-FE-beta-CIT) as well as the dopamine D1-like ([11C]-(+)-SCH23390) and the D2-like receptors ([11C]-raclopride) in the male rat brain. Chronic treatment with the AAS nandrolone decanoate (15 mg/kg/day for 14 days) caused an up-regulation of the binding potential of the dopamine transporter in the striatum.
authors.affiliation: Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Box 591, S-751-24 Uppsala, Sweden. Anna.Kindlundh@farmbio.uu.se
authors.forename: Anna M S
authors.initials: AM
authors.lastname: Kindlundh
authors.forename: Mats
authors.initials: M
authors.lastname: Bergström
authors.forename: Azita
authors.initials: A
authors.lastname: Monazzam
authors.forename: Mathias
authors.initials: M
authors.lastname: Hallberg
authors.forename: Gunnar
authors.initials: G
authors.lastname: Blomqvist
authors.forename: Bengt
authors.initials: B
authors.lastname: Långström
authors.forename: Fred
authors.initials: F
authors.lastname: Nyberg
mesh_terms: D045930:Anabolic Agents / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D050483:Dopamine Plasma Membrane Transport Proteins; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000187:drug effects*; D009277:Nandrolone / Q000009:adverse effects* / Q000494:pharmacology; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology; D014055:Tomography, Emission-Computed; D015854:Up-Regulation
chemical_list: D045930:Anabolic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D009277:Nandrolone