[Participation of the brain catecholamines in changes in activity of the rat hypophyseal-adrenal system induced by hydrocortisone administration during neonatal ontogenesis].
Administration of hydrocortisone or 6-hydroxydopamine (6-ONDA) to little rats from the 1st to the 5th day of life affected functional activity of the hypophyseal-adrenal system (HAS) of immature rats. In the morning hours, the rats developed a decrease in the basal and stressor levels of corticosterone in the blood, whereas administration of the 6-ONDA did not change the functional activity of the HAS in the morning. The data obtained suggest that disorders in the HAS regulation by the feedback mechanism resulting from neonatal administration of hydrocortisone may be associated with a drop in the noradrenaline level in the hypothalamus.
Ordian
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NE
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6.
Pivina
S G
SG
Rakitskaia
V V
VV
D018663:Adrenergic Agents / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood*; D002940:Circadian Rhythm; D006854:Hydrocortisone / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D016627:Oxidopamine / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats
D018663:Adrenergic Agents; D002395:Catecholamines; D016627:Oxidopamine; D006854:Hydrocortisone