Increasing effect of nori on the fecal excretion of dioxin by rats.
The effects of nori (Porphyra yezoensis), a kind of red alga, on the gastrointestinal absorption and reabsorption of 17 types of dioxin were investigated in male Wistar rats. The rats were fed with 4 g of the control diet or 4 g of the nori diet containing a standard dioxin solution (233 ngTEQ/kg of body weight) for five consecutive days. In the group fed with the 10% nori diet, the fecal excretion of dioxin from days 1 to 5 was higher (p<0.01) than that of the control group by 5.5-fold for 2,3,7,8-TCDD, 6.6-fold for 1,2,3,7,8-pentaCDD, and 6.0-fold for 2,3,4,7,8-pentaCDF. In another experiment, the rats were fed with 4 g of the control diet containing a standard dioxin solution (2991 ngTEQ/kg of body weight) on the first day of the experiment and then given the control diet for 7 consecutive days, before being given either the control diet or the nori diet for 28 consecutive days more. In the group fed with the 10% Nori diet, the fecal excretion of dioxin during the period from days 8 to 35 was higher (p<0.01 or p<0.05) than that of the control group by 2.4-fold for 2,3,7,8-TCDD, 2.3-fold for 1,2,3,7,8-pentaCDD, and 2.4-fold for 2,3,4,7,8-pentaCDF. These results suggest that the administration of nori prevented dioxin from being efficiently absorbed and reabsorbed from the gastrointestinal tract, and might be useful for protecting humans exposed to dioxin from ill effects.
Morita
Kunimasa
K
Fukuoka Institute of Health and Environmental Sciences, Dazaifu City, Fukuoka 818-0135, Japan. morita@star.fihes.pref.fukuoka.jp
Tobiishi
Kazuhiro
K
D000818:Animals; D001572:Benzofurans / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004147:Dioxins / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D005247:Feeding Behavior / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D008297:Male; D010938:Plant Oils; D051381:Rats; D017208:Rats, Wistar; D000461:Rhodophyta; D013997:Time Factors
D001572:Benzofurans; D004147:Dioxins; D006843:Hydrocarbons, Chlorinated; D010938:Plant Oils