title: Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity.
abstract: A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.
authors.affiliation: Department of Pharmacy, Veterans General Hospital Kaohsiung, Taipei, Tawain, ROC.
authors.forename: Pili Chih-Min
authors.initials: PC
authors.lastname: Mao
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Mouscadet
authors.forename: Herve
authors.initials: H
authors.lastname: Leh
authors.forename: Christian
authors.initials: C
authors.lastname: Auclair
authors.forename: Ling-Yih
authors.initials: LY
authors.lastname: Hsu
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D019427:HIV Integrase / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D019428:HIV Integrase Inhibitors; D019427:HIV Integrase