Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure.
Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.
Abraham
P
P
Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK. p.abraham@arh.grampian.scot.nhs.uk
Ralston
S H
SH
Hewison
M
M
Fraser
W D
WD
Bevan
J S
JS
D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D009363:Neoplasm Proteins / Q000378:metabolism; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones / Q000378:metabolism; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones