Platinum compounds and therapy related acute promyelocytic leukemia.
Therapy related acute promyelocytic leukemia (ta-APL) is a rare complication of chemotherapy for other malignant tumors. We report two such cases, one of whom was exposed only to carboplatin two years before developing ta-APL and the other one was treated with cisplatin, etoposide and bleomycin five years prior to developing ta-APL.
Martin
Jacqueline
J
Haematology Department, Doncaster Royal Infirmary, Thorne Road, Doncaster, DN2 5LT, UK.
Majumdar
Gautam
G
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D016190:Carboplatin / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D017671:Platinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D017671:Platinum Compounds; D016190:Carboplatin; D002945:Cisplatin