[Plasma erythropoietin concentration in lung cancer patients].
The goal of this study was to evaluate serum level of EPO in 32 men with lung cancer (Squamous cell lung cancer N = 11, Adenocarcinoma N = 10, Small cell lung cancer N = 11) in relation to the degree of anemia, stage of disease and the regimen of anticancer therapy. The control group consisted of 29 men, among whom were 15 patients with posthemorrhagic anemia. Blood samples were withdrawn for assessment of blood count, serum concentration of EPO, iron, total iron binding capacity (TIBC) and ferritin. The assessment of all parameters was repeated after 3 months of therapy:


RESULTS
Patients suffering from lung cancer were characterized by a lower hemoglobin level and higher level of EPO as compared with the control group. A significant negative correlation was found between hemoglobin level and EPO serum concentration in all groups of patients and in the control group. The strongest correlation was observed in the control group t = -0.812. In each group of patients the serum level of EPO increased after treatment; although a significant increase was found only in surgically treated patients and patients after chemotherapy. After treatment the correlation between hemoglobin and EPO became stronger especially in the group of patients with small cell lung cancer.


CONCLUSIONS
1. Patients with lung cancer are characterized by inappropriately low serum EPO levels when related to the degree of anemia, 2. The suppressive effect of lung cancer on EPO secretion depends on the histological type of the cancer (with the exception of small cell lung cancer). 3. The increase of EPO level after treatment seems to be caused not only by a decrease of hemoglobin concentration, but also by reduction of the tumor mass.
Łapa
Katarzyna
K
Katedry i Kliniki Nefrologii, Endokrynologii i Chorób Przemiany Materii SAM w Katowicach.
Kokot
Franciszek
F
Oklek
Kazimierz
K
Cieślicki
Jan
J
Machalski
Marek
M
Chudek
Jerzy
J
Wiecek
Andrzej
A
D000230:Adenocarcinoma / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D000740:Anemia / Q000097:blood / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D016022:Case-Control Studies; D004921:Erythropoietin / Q000097:blood*; D005293:Ferritins / Q000097:blood; D006441:Hemoglobin A / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D015415:Biomarkers; D004921:Erythropoietin; D005293:Ferritins; D006441:Hemoglobin A; D007501:Iron