title: The effect of cobalt compounds on uninfected and Ascaridia galli-infected chickens: a kinetic model for Ascaridia galli populations and chicken growth.
abstract: The effect of dietary cobalt from three different sources on uninfected and Ascaridia galli-infected Hisex chickens, has been studied. The chicken diet was supplemented with 0.06 Co2+ kg-1 food either in the form of two glycine-cobalt compounds or mixed zinc-cobalt basic salt. An excess of dietary cobalt in small doses increases the gain of body weight and decreases host mortality. A greater bioefficiency of cobalt was established in infected chickens. A mathematical model has been used to provide a quantitative interpretation of the observed results. The model solutions of the kinetics of worm numbers and body weight are in a good agreement with experimental data. The model is valid for different degrees of A. galli infections and for treatment with different trace elements. The value of the kinetic parameter, regarded as a phenomenological constant of the host immune response, depends on the degree of infection.
authors.affiliation: Institute for Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 25, 1113 Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Gabrashanska
authors.forename: S E
authors.initials: SE
authors.lastname: Teodorova
authors.forename: M
authors.initials: M
authors.lastname: Mitov
mesh_terms: D000818:Animals; D001197:Ascaridia / Q000302:isolation & purification; D001198:Ascaridiasis / Q000188:drug therapy* / Q000503:physiopathology; D018533:Biomass; D002645:Chickens / Q000254:growth & development / Q000469:parasitology*; D003035:Cobalt / Q000627:therapeutic use*; D019587:Dietary Supplements; D008297:Male; D008954:Models, Biological; D011201:Poultry Diseases / Q000188:drug therapy* / Q000503:physiopathology; D015996:Survival Rate; D015430:Weight Gain / Q000187:drug effects
chemical_list: D003035:Cobalt