title: Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes.
abstract: In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, South, Korea.
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Young-Pyo
authors.initials: YP
authors.lastname: Kim
authors.forename: Hyun-Bae
authors.initials: HB
authors.lastname: Kim
authors.forename: Kwang-Sik
authors.initials: KS
authors.lastname: Lee
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D018891:Dentate Gyrus / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D008297:Male; D005894:Panax / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts