[A drop of mink complement kills a mouse].
The phenomenon of fast death of mice after parenteral administration of mink serum was explained by high activity of mink complement in particular by unusually high activity of its alternative pathway of activation. The presence of antibodies to mouse erythrocytes in mink serum was necessary precondition for their lysis under action of mink complement by classical and alternative pathways. However, removal of these antibodies resulting in cancellation of hemolysis did not effect toxicity of mink serum for nice in vivo. Partial decomplementization of mink serum zymosan completely prevented death of animals.
Belkin
Z P
ZP
Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of Health Ministry of Russian Federation, 125212 Moscow.
Kozlov
L V
LV
Andina
S S
SS
Mishin
A A
AA
Guzova
V A
VA
D'iakov
V L
VL
D000818:Animals; D000906:Antibodies / Q000097:blood; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology / Q000633:toxicity*; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D008907:Mink / Q000097:blood* / Q000276:immunology; D013045:Species Specificity
D000906:Antibodies; D003165:Complement System Proteins