Sesquiterpenes from Ferula penninervis.
The ethyl acetate soluble extract of the dried roots of Ferula penninervis gave 17 new sesquiterpenes [15 of the guaiane-type, ferupennins A-O (1-15), and two of the eudesmane-type, 1alpha-hydroxy-2-oxo-5alpha,7beta,11betaH-eudesm-3-en-6alpha,12-olide (16) and penninervin (17)] and nine known sesquiterpenes. The structures of the new compounds were elucidated on the basis of spectroscopic evidence and X-ray analysis. The absolute configuration of ferupennin A (1) was determined by a modified Mosher method.
Shikishima
Yasuhiro
Y
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
Takaishi
Yoshihisa
Y
Honda
Gisho
G
Ito
Michiho
M
Takeda
Yoshio
Y
Tori
Motoo
M
Takaoka
Shigeru
S
Kodzhimatov
Olimjon K
OK
Ashurmetov
Ozodbek
O
D000085:Acetates; D000107:Acetylation; D000328:Adult; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D005309:Ferula / Q000737:chemistry*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014610:Uzbekistan
D000085:Acetates; D007375:Interleukin-1; D007376:Interleukin-2; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; C007650:ethyl acetate