Inflammatory bowel disease in pregnancy.
Women and men with inflammatory bowel disease (IBD) frequently express concerns about fertility and pregnancy. The evidence suggests that women with IBD can expect to have a normal pregnancy outcome provided they have inactive disease. They have an increased risk of having a small or premature baby but the majority will have a normal outcome of pregnancy. The commonly used drugs appear to be safe and well tolerated in pregnancy. There remains a need for further studies in this area to help in the difficult decisions about the management of IBD around the time of conception and during pregnancy.
Alstead
E M
EM
Bart's and the London School of Medicine, and Whipps Cross University Hospital, London, UK. e.m.almstead@mds.qmw.ac.uk
Nelson-Piercy
C
C
D000636:Aminosalicylic Acids / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D007248:Infertility, Male / Q000139:chemically induced; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000209:etiology*; D011256:Pregnancy Outcome; D013256:Steroids / Q000009:adverse effects; D012460:Sulfasalazine / Q000009:adverse effects
D000636:Aminosalicylic Acids; D013256:Steroids; D012460:Sulfasalazine; D001379:Azathioprine; D008727:Methotrexate