title: The Ontario Uterine Fibroid Embolization Trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids.
abstract: OBJECTIVE
  To evaluate fibroid uterine volume reduction, symptom relief, and patient satisfaction with uterine artery embolization (UAE) for symptomatic fibroids.
  
  
  METHODS
  Multicenter, prospective, single-arm clinical treatment trial.
  
  
  METHODS
  Eight Ontario university and community hospitals. Five hundred thirty-eight patients undergoing bilateral UAE.
  
  
  METHODS
  Bilateral UAE performed with polyvinyl alcohol particles sized 355-500 microm.
  
  
  METHODS
  Three-month follow-up evaluations including fibroid uterine volume reductions, patient reported symptom improvement (7-point scale), symptom life-impact (10-point scale) reduction, and treatment satisfaction (6-point scale).
  
  
  RESULTS
  Median uterine and dominant fibroid volume reductions were 35% and 42%, respectively. Significant improvements were reported for menorrhagia (83%), dysmenorrhea (77%), and urinary frequency/urgency (86%). Mean menstrual duration was significantly reduced after UAE (7.6 to 5.4 days). Improvements in menorrhagia were unrelated to pre-UAE uterine size or post-UAE uterine volume reduction. Amenorrhea occurring after the procedure was highly age dependent, ranging from 3% (1%-7%) in women under age 40 to 41% (26%-58%) in women age 50 or older. Median fibroid life-impact scores were significantly reduced after UAE (8.0 to 3.0). The majority (91%) expressed satisfaction with UAE treatment.
  
  
  CONCLUSIONS
  UAE reduced fibroid uterine volume and provided significant relief of menorrhagia that was unrelated to initial fibroid uterine size or volume reduction. Patient satisfaction with short-term UAE treatment outcomes was high.
authors.affiliation: Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada. g.pron@utoronto.ca
authors.forename: Gaylene
authors.initials: G
authors.lastname: Pron
authors.forename: John
authors.initials: J
authors.lastname: Bennett
authors.forename: Andrew
authors.initials: A
authors.lastname: Common
authors.forename: Jane
authors.initials: J
authors.lastname: Wall
authors.forename: Murray
authors.initials: M
authors.lastname: Asch
authors.forename: Kenneth
authors.initials: K
authors.lastname: Sniderman
mesh_terms: D000328:Adult; D001158:Arteries; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000628:therapy*; D008595:Menorrhagia / Q000628:therapy; D008875:Middle Aged; D009864:Ontario; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D014555:Urination Disorders / Q000628:therapy; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy*; D014599:Uterus / Q000098:blood supply* / Q000473:pathology