title: Effect of intravenous infusion of isotonic sodium bicarbonate solution on acidemic calves with diarrhea.
abstract: The effect of 1.35% isotonic sodium bicarbonate solution (ISB) administered intravenously on acid-base equilibrium was examined in 18 acidemic Japanese black beef calves with spontaneous diarrhea. The infusion volumes of ISB were decided based on the first half volumes of base needed. In 72.2% (13/18) of calves, improvement of acidemia was detected. There was good correlation (r=0.693, p<0.01) between infused volume of ISB and changes in base excess (y=1.097x + 4.762). Infusion volumes of ISB were 7.5, 10.2, 12.9 and 15.7 ml/kg, respectively, enough to correcting the first half of 5, 10, 15 and 20 mEq/l of base deficit in acidemic calves. Our finding suggested that ISB could be used to correct metabolic acidosis without altering electrolyte concentrations in calves.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tosihide
authors.initials: T
authors.lastname: Kato
authors.forename: Gensei
authors.initials: G
authors.lastname: Tsunoda
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Kimi
authors.initials: K
authors.lastname: Asano
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000150:complications / Q000188:drug therapy* / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017693:Sodium Bicarbonate / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007552:Isotonic Solutions; D017693:Sodium Bicarbonate