title: Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise.
abstract: The expression of c-Fos, an immediately early gene, is a marker of neural activity. In the present study, the effect of treadmill exercise on c-Fos expression was investigated in various regions of the rat hippocampus via immunohistochemistry. The first part of the experiment was aimed at determining the dependence of c-Fos expression on the intensity of treadmill exercise. In most of the hippocampal regions studied, increasing c-Fos expression was observed with increasing exercise intensity. In the second part of the experiment, the dependence of c-Fos expression on the duration of treadmill exercise was investigated. The c-Fos expression induced by mild-intensity exercise increased until the 7th day of exercise and subsequently decreased. Results of the present study suggest that the effect of treadmill exercise on neuronal activity in the hippocampus is intensity-and duration-dependent.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Young-Pyo
authors.initials: YP
authors.lastname: Kim
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Hyun-Hee
authors.initials: HH
authors.lastname: Choi
authors.forename: Kwang-Sik
authors.initials: KS
authors.lastname: Lee
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000737:chemistry; D006624:Hippocampus / Q000737:chemistry* / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D005082:Physical Exertion / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000032:analysis; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D011965:Receptors, Glucocorticoid