title: [Indications for in vitro fertilization: comparison of the Dutch guidelines with the published evidence].
abstract: The guideline 'Indications for in vitro fertilisation (IVF)' of the Dutch Society for Obstetrics and Gynaecology (Dutch acronym: NVOG) reports limited international evidence on this subject. A review of the published studies of effectiveness and cost-effectiveness shows that the possibilities to compare the studies and to translate the results to the diagnostic indications according to the Dutch guideline are indeed limited. This is due to differences in the study-populations, different outcome measures and differences in the severity of the underlying pathology. The results of foreign cost-effectiveness studies cannot easily be generalised to the Dutch situation due to differences in the consumption of medical care, the policy as to indications and the price-structure. For the indications inoperable tubal pathology and, to a lesser extent, severe male subfertility there is sufficient evidence-based support for the (cost-)effectiveness of IVF or intracytoplasmic sperm injection (ICSI) in comparison to waiting for spontaneous pregnancy to occur. There is insufficient current literature to support recommendations for the other causes of infertility as given in the Dutch guideline.
authors.affiliation: Erasmus Universiteit Rotterdam, Institute for Medical Technology Assessment, Postbus 1738, 3000 DR Rotterdam. bouwmans@bmg.eur.nl
authors.forename: C A M
authors.initials: CA
authors.lastname: Bouwmans
authors.forename: E W M
authors.initials: EW
authors.lastname: Grijseels
authors.forename: D D M
authors.initials: DD
authors.lastname: Braat
authors.forename: J L H
authors.initials: JL
authors.lastname: Evers
authors.forename: D J
authors.initials: DJ
authors.lastname: Hemrika
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics; D006801:Humans; D007246:Infertility / Q000209:etiology* / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D009426:Netherlands; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011256:Pregnancy Outcome; D012955:Societies, Medical; D016896:Treatment Outcome