[Effects of qufengshi prescription on release of hydrogen peroxide and interleukin-1 from peritoneal macrophage in adjuvant arthritis rat].
OBJECTIVE
To study the mechanism of antiarthritis effects of Qufengshi Prescription.


METHODS
Adjuvant arthritis (AA) was applied as pathological model of rheumatoid arthritis and prednisone was used as positive control.


RESULTS
The Prescription at high and medium dosages significantly decreased the rising level of hydrogen peroxide and interleukin-1 in AA rats (P < 0.05), the potency being similar to prednisone.


CONCLUSIONS
Qufengshi Prescription Could reduce the rising level of interleukin-1 and hydrogen peroxide in AA rats, which may be part of mechanism of the antiarthritis effect.
Zhang
W Y
WY
Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China.
Weng
F H
FH
Zhang
C L
CL
D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D051381:Rats
D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D006861:Hydrogen Peroxide