Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.
Rats discriminated the novel antipsychotic quetiapine (Seroquel). Full generalization was seen with the novel ("atypical") antipsychotics, clozapine, olanzapine, and risperidone. Generalization was not seen with the older "typical" antipsychotics, haloperidol, chlorpromazine, and loxapine, or with the novel atypical antipsychotic, amisulpride. The pattern of generalization resembled that seen in rats trained to discriminate a low dose (1.25 mg/kg) of clozapine, which dissociates most novel antipsychotics from typical antipsychotics. However, the failure of the novel antipsychotic amisulpride to generalize demonstrates that this bioassay does not detect all novel antipsychotics. These data suggest that the discrimination of antipsychotics such as quetiapine may be of value in the development of novel antipsychotics, although the relationship between the discriminative properties of such drugs and their clinical actions is unclear.
Smith
Judith A
JA
Department of Psychology, Liverpool University, United Kingdom.
Goudie
Andrew J
AJ
D000077582:Amisulpride; D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D004193:Discrimination Learning; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005793:Generalization, Psychological; D006220:Haloperidol / Q000494:pharmacology; D008152:Loxapine / Q000494:pharmacology; D000069348:Quetiapine Fumarate; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018967:Risperidone / Q000494:pharmacology; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000494:pharmacology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D011810:Quinoxalines; D000069348:Quetiapine Fumarate; D013469:Sulpiride; D000077582:Amisulpride; C013168:olaquindox; D003024:Clozapine; D006220:Haloperidol; D018967:Risperidone; D008152:Loxapine; D002746:Chlorpromazine