title: Low avidity IgG antibodies in diagnosis of recent human schistosomiasis.
abstract: One hundred thirty school children from a schistosomiasis endemic area in Sharkia Governorate, were selected on parasitological findings. Seventy persons were negative on the first screen and turned positive after 3 months of the screening (recently infected). Stool examination, ELISA (IgG & IgM), low avid IgG, and circulating antigens were performed for all patients and controls. ELISA detected IgM in all cases. IgG and circulating antigens in 90% of schistosomiasis patients. Low avidity IgG were detected in 85.71% of recent cases. The specificity of ELISA appeared to be >99%. The IgM/IgG ratio was >1 in patients with recent infection. The percentage of fall of O.D. readings of IgG after addition of 6 molar urea was high among cases with recent infection. Low avid lgG appears to be good and valuable in diagnosis of recent schistosomiasis in man.
authors.affiliation: Department of Parasitology, Faculties of Medicine, Zagazig, El-Menia, Egypt.
authors.forename: Nahed E
authors.initials: NE
authors.lastname: Mostafa
authors.forename: Adel
authors.initials: A
authors.lastname: Awad
authors.forename: Mohsen
authors.initials: M
authors.lastname: Shalaby
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000915:Antibody Affinity; D004534:Egypt; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005243:Feces / Q000469:parasitology; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D010270:Parasite Egg Count; D012552:Schistosomiasis / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007075:Immunoglobulin M