Drug-induced hepatitis with hepatic granuloma due to saridon.
A 38-year-old Japanese woman with no past history of liver disease developed liver dysfunction associated with fever, anorexia, and general malaise following the prolonged administration of saridon. A liver biopsy demonstrated multiple noncaseating epithelioid granulomas within hepatic lobules, with an inflammatory cell infiltrate of the lobular parenchyma and portal tracts. Viral markers and autoantibodies were negative. Lymphocyte stimulation tests for saridon and for isopropylantipyrine, one of the constituents of saridon, were positive, and therefore a diagnosis of drug-induced hepatitis due to administration of saridon was made. Her symptoms resolved and liver function test results returned to normal following discontinuation of the drug. The possibility of drug-induced hepatitis must be considered when liver dysfunction or systemic symptomatology develops during saridon therapy.
Abe
Masanori
M
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan.
Kumagi
Teru
T
Nakanishi
Seiji
S
Yamagami
Takashi
T
Michitaka
Kojiro
K
Abe
Kayo
K
Okura
Izumi
I
Yamashita
Haruhiko
H
Horiike
Norio
N
Onji
Morikazu
M
D000328:Adult; D000983:Antipyrine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001707:Biopsy, Needle; D002110:Caffeine / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D006261:Headache / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008111:Liver Function Tests; D010615:Phenacetin / Q000009:adverse effects* / Q000627:therapeutic use; D011728:Pyridones / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index
D004338:Drug Combinations; D011728:Pyridones; D002110:Caffeine; C019552:Saridon; D010615:Phenacetin; D000983:Antipyrine