title: Acute vascular and interstitial rejection following renal allograft transplantation in dogs.
abstract: Renal allograft transplantation was performed in four beagles. Immunosuppressive treatment using cyclosporine, mizoribin and prednisolone was continued from Day 5 pre- until Day 20 post-transplantation. Between Days 28 and 32 post-transplantation, an abrupt elevation of the serum creatinine values followed by the development of uremia was seen in all recipients. Histopathology of the allografts examined between Days 28 and 37 revealed edema, necrosis, hemorrhage and severe diffuse interstitial cellular infiltration as well as tubulitis. Glomerular changes notably included swelling of the tufts due to hypercellularity, which was consistent with transplant glomerulitis. The intrarenal arteries exhibited fibrinoid necrosis of the walls and intimal or transmural cellular infiltration. These renal lesions were consistent with those of acute vascular and interstitial rejection in humans.
authors.affiliation: Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Haishima
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kageyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Muto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Inoue
authors.forename: Kinji
authors.initials: K
authors.lastname: Shirota
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012263:Ribonucleosides / Q000627:therapeutic use; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D016572:Cyclosporine; D011239:Prednisolone