title: Biodegradable micelles/polymersomes from fumaric/sebacic acids and poly(ethylene glycol).
abstract: Linear unsaturated oligo-anhydrides containing terminal acylchloride groups have been synthesized by polycondensation of fumaric or sebacic acid with either fumaryl chloride or sebacoyl chloride. Reaction of these oligo-anhydrides with poly(ethylene glycol) produce di- and tri-block copolymers. The oligo-anhydrides and block copolymers have been characterized by gel permeation chromatography (GPC), NMR and FT-IR spectroscopies. The tri-block copolymers composed of two PEG end blocks and an oligo-anhydride center block have been used in encapsulation of calcein (encapsulation efficiency up to 40%). Encapsulation and release profile of calcein (as a model hydrophilic drug) from the di-block copolymers (micelles) and tri-block copolymer vesicles (polymersomes) as well as their in-vitro hydrolytic degradation (pH=7.4 degrees C, 37 degrees C) are reported.
authors.affiliation: Chemistry Department, Faculty of Science, Tehran University, Tehran, Iran.
authors.forename: Farhood
authors.initials: F
authors.lastname: Najafi
authors.forename: Mohammad N
authors.initials: MN
authors.lastname: Sarbolouki
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002850:Chromatography, Gel; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D005650:Fumarates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004337:Drug Carriers; D005650:Fumarates; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols; C032005:fumaric acid; C011107:sebacic acid