title: Autoimmune pancreatitis successfully treated with ursodeoxycholic acid.
abstract: A 51-year-old woman with autoimmune pancreatitis is reported in whom treatment with ursodeoxycholic acid (UDCA) was beneficial. Complaining of epigastric discomfort, she presented with liver dysfunction of the cholestatic type, and diabetes mellitus. Pancreatic imaging revealed a diffuse swelling of the body, an irregular narrowing of the main pancreatic duct, and a terminal stricture of the common bile duct. Histologically, the biopsied pancreas was replaced by fibrous tissue with a small amount of mononuclear cell infiltration. She had anti-carbonic anhydrase-II antibody and anti-lactoferrin antibody. After treatment with UDCA, her liver dysfunction and diabetes mellitus improved and the pancreas size was reduced. Steroid therapy is usually indicated for this disorder, but UDCA may be given as an alternative choice.
authors.affiliation: Department of Internal Medicine, Ashiya Municipal Hospital, Hyogo.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tsubakio
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kiriyama
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Matsushima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Takae
authors.initials: T
authors.lastname: Shizusawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Katoh
authors.forename: Noriko
authors.initials: N
authors.lastname: Manabe
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yabu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kanayama
authors.forename: Seiichi
authors.initials: S
authors.lastname: Himeno
mesh_terms: D000792:Angiography; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001707:Biopsy, Needle; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D005260:Female; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D007159:Immunologic Tests / Q000379:methods; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D014580:Ursodeoxycholic Acid