The role of innate cytokines in inflammatory response.
Mediators produced by innate immune response cells such as macrophages can profoundly influence adaptive immunity. Recent studies have shown that IL-15 and IL-18 play an influential role in inflammatory response. Here I present recent data mainly from our own laboratories illustrating the importance of IL-15 and IL-18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis. These findings suggest that antagonists to these cytokines may have a potential therapeutic role against organ-specific autoimmune diseases.
Liew
Foo Y
FY
Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland G11 6NT, UK. fy11h@clinmed.gla.ac.uk
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D019409:Interleukin-15 / Q000276:immunology* / Q000502:physiology; D020382:Interleukin-18 / Q000276:immunology* / Q000502:physiology; D008213:Lymphocyte Activation / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D019409:Interleukin-15; D020382:Interleukin-18