title: Poly(D, L-lactide/epsilon-caprolactone)/hydroxyapatite composites as bone filler: an in vivo study in rats.
abstract: In this study, a novel composite bone substitute was implanted in animal models (rats) and their in vivo characteristics were examined. A D,L-lactide and E-caprolactone copolymer (Mw: 80,000; Mn:40,000, and PI:2.00) was synthesized by ring-opening polymerization of the respective dimers using stannous octoate as the catalyst. The final ratio of D,L-lactide to epsilon-caprolactone obtained by 1NMR was 60/40. Hydroxyapatite (HA) powder was loaded in the copolymer. The HA/copolymer ratio was 60/40 (w/w). These composites were easily shaped by hand. Animal tests were performed on mature wistar rats (n=30). Defects were created on the proximal, the thickest part of the femur. The bone defects of the first group were filled with polymer/HA composite, the second group filled with only HA and the third group was left empty. Histologic examination of bone tissues showed new bone formation around the yellow-green polymer/HA composite material in the first group of animals whereas no evidence of new bone growth was observed in other groups.
authors.affiliation: Middle East Technical University, Medical Center, Inönü Bulvari, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Senköylü
authors.forename: E
authors.initials: E
authors.lastname: Ural
authors.forename: K
authors.initials: K
authors.lastname: Kesencì
authors.forename: A
authors.initials: A
authors.lastname: Sìmşek
authors.forename: S
authors.initials: S
authors.lastname: Ruacan
authors.forename: L
authors.initials: L
authors.lastname: Fambri
authors.forename: C
authors.initials: C
authors.lastname: Migliaresi
authors.forename: E
authors.initials: E
authors.lastname: Pìskìn
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000628:therapy; D018786:Bone Substitutes / Q000737:chemistry*; D005269:Femur / Q000473:pathology*; D023421:Models, Animal; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C062968:lactide-caprolactone copolymer