title: Microstimulation of macaque V1 disrupts target selection: effects of stimulation polarity.
abstract: Microstimulation of the intermediate layers of V1 in rhesus monkeys disrupts target selection with saccadic eye movements. To study target selection, one visual target was presented in the receptive-field location of the stimulated neurons and a second target was presented outside this location. Microstimulation delivered with the appearance of the two targets decreased the probability that the monkey would select the target placed in the receptive-field location when intermediate layers of V1 were stimulated. This interference effect was more pronounced when anodal-first pulse pairs were used as compared to when cathodal-first pulse pairs were used. The superior effectiveness of anodal pulses suggests that the interference effect is due to activation of axonal terminals residing within intermediate V1.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, E25-634, Cambridge, MA 02139, USA. tehovnik@mit.edu
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Tehovnik
authors.forename: Warren M
authors.initials: WM
authors.lastname: Slocum
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D008253:Macaca mulatta; D008297:Male; D008839:Microelectrodes; D010775:Photic Stimulation / Q000379:methods*; D012438:Saccades / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*