title: ECVAM's activities on computer modelling and integrated testing.
abstract: This paper introduces the basic concepts of quantitative structure-activity relationship (QSAR), expert system and integrated testing strategy, and explains how the analogy between QSARs and prediction models leads naturally to criteria for the validation of QSARs. ECVAM's in-house research programme on QSAR modelling and integrated testing is summarised, along with plans for the validation of QSAR models and expert system rulebases at the European Union level.
authors.affiliation: ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Worth
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D003198:Computer Simulation; D005062:European Union; D005103:Expert Systems; D006801:Humans; D011237:Predictive Value of Tests; D021281:Quantitative Structure-Activity Relationship; D015203:Reproducibility of Results; D018675:Toxicity Tests / Q000379:methods*; D015262:Xenobiotics / Q000737:chemistry / Q000145:classification
chemical_list: D015262:Xenobiotics