Molecular etiology of gut malformations and diseases.
This review describes recent advances using animal models in the analysis of the molecular controls of gastrointestinal development, with specific attention to mutations causing maldevelopment similar to those seen in human gut malformations. By focusing on specific human gut pathologic conditions and maldevelopment, we describe the probable roles of signaling pathways, including the hedgehog pathway, the bone morphogenic protein pathway, and the role of the homeotic genes.
de Santa Barbara
Pascal
P
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
van den Brink
Gijs Robert
GR
Roberts
Drucilla Jane
DJ
D000818:Animals; D004064:Digestive System / Q000196:embryology / Q000294:innervation; D004065:Digestive System Abnormalities; D004195:Disease Models, Animal; D017615:Enteric Nervous System; D005767:Gastrointestinal Diseases / Q000196:embryology / Q000209:etiology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D006801:Humans; D009024:Morphogenesis; D015534:Trans-Activators
D053823:Hedgehog Proteins; D015534:Trans-Activators