title: Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes.
abstract: OBJECTIVE
  To evaluate the hypothesis that macular thickness correlates with the diagnosis of glaucoma.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  We studied 367 subjects (534 eyes), including 166 eyes of 109 normal subjects, 83 eyes of 58 glaucoma suspects, 196 eyes of 132 early glaucoma patients, and 89 eyes of 68 advanced glaucoma patients.
  
  
  METHODS
  We used optical coherence tomography (OCT) to measure macular and nerve fiber layer (NFL) thickness and to analyze their correlation with each other and with glaucoma status. We used both the commercial and prototype OCT units and evaluated correspondence between measurements performed on the same eyes on the same days.
  
  
  METHODS
  Macular and NFL thickness as measured by OCT.
  
  
  RESULTS
  All NFL parameters both in prototype and commercial OCT units were statistically significantly different comparing normal subjects and either early or advanced glaucoma (P < 0.001). Inner ring, outer ring, and mean macular thickness both in prototype and commercial OCT devices were found to be significantly different between normal subjects and advanced glaucomatous eyes (P < 0.001). The outer ring was the only macular parameter that could significantly differentiate between normal and early glaucoma with either the prototype or commercial OCT unit (P = 0.003, P = 0.008, respectively). The area under the receiver operator characteristic (AROC) curves comparing mean NFL thickness between normal and advanced glaucomatous eyes was 1.00 for both the prototype and commercial OCT devices for eyes scanned on both machines on the same day. The AROC comparing mean macular thickness in normal and advanced glaucomatous eyes scanned on both machines on the same day was 0.88 for the prototype OCT device and 0.80 for the commercial OCT.
  
  
  CONCLUSIONS
  Both macular and NFL thickness as measured by OCT showed statistically significant correlations with glaucoma, although NFL thickness showed a stronger association than macular thickness. There was good correspondence between findings using both the prototype and commercial OCT units. Macular and NFL thickness measurements made with OCT may have usefulness in the clinical assessment of glaucoma.
authors.affiliation: New England Eye Center, Tufts School of Medicine, Boston, Massachusetts 02111, USA.
authors.forename: Viviane
authors.initials: V
authors.lastname: Guedes
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
authors.forename: Ellen
authors.initials: E
authors.lastname: Hertzmark
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Anthony
authors.initials: A
authors.lastname: Correnti
authors.forename: Ronald
authors.initials: R
authors.lastname: Mancini
authors.forename: David
authors.initials: D
authors.lastname: Lederer
authors.forename: Serineh
authors.initials: S
authors.lastname: Voskanian
authors.forename: Leonardo
authors.initials: L
authors.lastname: Velazquez
authors.forename: Helena M
authors.initials: HM
authors.lastname: Pakter
authors.forename: Tamar
authors.initials: T
authors.lastname: Pedut-Kloizman
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Cynthia
authors.initials: C
authors.lastname: Mattox
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007368:Interferometry; D008027:Light; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D014054:Tomography / Q000379:methods; D014794:Visual Fields