title: Case control study on health-related quality of life in adult coeliac disease.
abstract: OBJECTIVE
  To evaluate whether health-related quality of life in adult coeliac disease is related to: 1) adhesion to gluten-free diet; 2) manifestation of clinical features; and 3) associated diseases.
  
  
  METHODS
  A total of 68 coeliac patients (54 female and 14 male) aged between 18 and 74 years, on gluten-free diet for at least two years were studied. The subjective health status was measured by means of the Short Form 36 Health Survey. A series of 136 subjects, matched according to sex, age and ethnic group, were evaluated as control group.
  
  
  RESULTS
  Patients obtained worse scores with respect to healthy controls at all domains of Short Form 36 Health Survey (p<0.05); compliers showed better results than non-compliers. The lowest scores were obtained in patients with more than six symptoms, mostly in non-compliers, the highest in compliers with less than six symptoms. Patients with two or more associated diseases presented significantly worse scores than patients with only one associated disease.
  
  
  CONCLUSIONS
  The importance of gluten-free diet in clinical management of coeliac disease is confirmed by results of the present study; moreover, the results seem to indicate that a complex interplay of factors should be taken into account in evaluating health-related quality of life in adult coeliac disease. Accordingly, our data show that health-related quality of life of coeliac patients is impaired not only by poor compliance but also by different negative factors such as severity of illness (in terms of number of symptoms) at diagnosis and comorbidity.
authors.affiliation: Department of Internal Medicine, Section of Psychiatry, Cagliari University, Italy. usaip@pacs.unica.it
authors.forename: P
authors.initials: P
authors.lastname: Usai
authors.forename: L
authors.initials: L
authors.lastname: Minerba
authors.forename: B
authors.initials: B
authors.lastname: Marini
authors.forename: R
authors.initials: R
authors.lastname: Cossu
authors.forename: S
authors.initials: S
authors.lastname: Spada
authors.forename: B
authors.initials: B
authors.lastname: Carpiniello
authors.forename: R
authors.initials: R
authors.lastname: Cuomo
authors.forename: M F
authors.initials: MF
authors.lastname: Boy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D005260:Female; D005983:Glutens; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life
chemical_list: D005983:Glutens