Clinical considerations in the management of individuals at risk for hereditary breast and ovarian cancer.
BACKGROUND
Hereditary predisposition to breast and ovarian cancer, most commonly due to germline mutations in BRCA1 and BRCA2, has been recognized for many years. The optimal clinical management of individuals with such a predisposition is not yet completely defined.


METHODS
The current literature regarding the clinical management of individuals at risk for hereditary breast and ovarian cancer was reviewed.


RESULTS
Women with germline BRCA1 or BRCA2 mutations are at substantially increased risk for breast and ovarian cancer, although the risks may not be as high as originally reported. Current surveillance options are restricted in their effectiveness by both host and tumor factors as well as limitations of the techniques. Surgical prevention options, while effective, may be complicated by physical or psychological morbidity. Nonsurgical prevention options are under development.


CONCLUSIONS
The ability to define women as being at hereditary risk for breast and ovarian cancer facilitates the use of specialized surveillance and prevention strategies. Genetic testing, which plays a role in defining risk, requires careful pre- and post-test counseling to discuss the limitations of testing itself and available management strategies.
Robson
Mark E
ME
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. robsonm@mskcc.org
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control*; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods; D014481:United States / Q000453:epidemiology