Synthesis of lipid A type carboxymethyl derivatives with ether chains instead of ester chains and their LPS-antagonistic activities.
Synthesis of lipid A type carboxymethyl derivatives having ether chains at both the C-3 and C-3' positions and their LPS-antagonistic activities toward human U937 cells are described.
Watanabe
Yukiko
Y
Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan.
Miura
Kumiko
K
Shiozaki
Masao
M
Kanai
Saori
S
Kurakata
Shin ichi
Si
Nishijima
Masahiro
M
D004986:Ether; D006801:Humans; D020128:Inhibitory Concentration 50; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D020298:U937 Cells
D008050:Lipid A; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D004986:Ether; C056260:GLA 60