Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis.
Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child.
Contopoulos-Ioannidis
Despina G
DG
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Grece. jioannid@cc.uio.gr
O'Brien
Thomas R
TR
Goedert
James J
JJ
Rosenberg
Phillip S
PS
Ioannidis
John P A
JP
D005060:Europe / Q000208:ethnology; D005260:Female; D015658:HIV Infections / Q000208:ethnology / Q000235:genetics* / Q000635:transmission*; D015497:HIV-1 / Q000502:physiology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D044469:Racial Groups / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics*; D012307:Risk Factors
D019713:Receptors, CCR5