Models for studying benign prostatic hyperplasia.
Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting aging man. Attempts have been made to clarify the etiology and pathogenesis and, to that end, experimental models have been developed. To date, in vitro and in vivo models have been used, depending on the concept of the study. Spontaneous animal models are limited to the chimpanzee and the dog. Ethical and financial factors restrict the applicability of these models. The hormonal-induced canine BPH model is a good alternative that closely resembles human BPH in many aspects. The experimental models currently used for studying BPH are reviewed. Prostate Cancer and Prostatic Diseases (2000) 3, 28-33
Mahapokai
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[1] Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands [2] Department of Veterinary Surgery, Khon-Kaen University, Thailand [3] Current address: Department of Veterinary Surgery, Khon-Kaen University, Khon-Kaen 40002, Thailand.
Van Sluijs
F J
FJ
Schalken
J A
JA