Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula.
Phytochemical examination of a Papua New Guinea collection of Lyngbya majuscula resulted in the discovery of wewakazole (1), a novel cyclic dodecapeptide containing an unprecedented six five-membered heterocycles. Multiple NMR experiments and MS/MS data were required to assemble its planar structure because of its extensively signal-overlapped NMR spectra. In particular, a 1D HMBC was utilized to orient a three amino acid fragment that could not be placed by standard spectroscopic methods. [structure--see text]
Nogle
Lisa M
LM
College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Marquez
Brian L
BL
Gerwick
William H
WH
D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010219:Papua New Guinea; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification*; D012624:Seaweed / Q000737:chemistry*
D010456:Peptides, Cyclic; C473357:wewakazole