title: [Determination of serum granulocyte colony-stimulating factor level in patients with chronic idiopathic neutropenia and its significance].
abstract: To investigate the serum granulocyte colony-stimulating factor (G-CSF) level in patients with chronic idiopathic neutropenia (CIN) and analyze its clinical significance. By the use of G-CSF-specific enzyme-linked immunosorbent assay (ELISA), the serum levels of G-CSF were determined in 40 cases with chronic CIN, 40 cases with systemic lupus erythematosus (SLE) complicated neutropenia and 40 healthy volunteer (normal control). Results showed that serum G-CSF was positive in 11 normal controls and in 10 cases with SLE, and the G-CSF levels were (27.34 +/- 8.00) ng/L and (26.76 +/- 7.26) ng/L, respectively. Serum G-CSF in 27 cases with CIN was positive, the level was (134.04 +/- 89.29) ng/L, which was higher than that in the normal controls and the cases with SLE (P < 0.01). It was concluded that an obstacle to utilization of G-CSF could be existed in the patients with CIN.
authors.affiliation: Department of Hematology, Sichuan Provincial People's Hospital, Chengdu 610072, China. wangchunsen@163.net
authors.forename: Chun-Sen
authors.initials: CS
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Jin-Lin
authors.initials: JL
authors.lastname: Zhang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Biao
authors.initials: B
authors.lastname: Zhu
authors.forename: Chun-Qian
authors.initials: CQ
authors.lastname: Wan
authors.forename: Mao-Zhou
authors.initials: MZ
authors.lastname: Gan
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor