Reversible MRI changes of hypothalamus in a multiple sclerosis patient with homeostatic disturbances.
Multiple sclerosis (MS) patients occasionally present with homeostatic disturbances suggestive of hypothalamic dysfunction; however, the hypothalamus often appears normal on imaging, apart from confirmation in a few necropsy studies. In this article we describe a Chinese woman with atypical clinical presentation. She presented with relapsing symptoms and signs consistent with hypothalamic dysfunction including hyperprolactinema, syndrome of inappropriate secretion of anti-diuretic hormone (SIADH), hypersomnolence and temperature dysregulation. Serial MRI depicted the atypical reversible changes in the hypothalamus, correlating with the observed homeostatic abnormalities.
Tsui
E Y K
EY
Department of Radiology, Tuen Mun Hospital, Tuen Mun. NT, Hong Kong Special Administrative Region, The People's Republic of China. eyktsui@hotmail.com
Yip
S F
SF
Ng
S H
SH
Cheung
Y K
YK
D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011859:Radiography