Post-exposure treatment of cats with mouse-cat chimeric antibodies against feline herpesvirus type 1 and feline calicivirus.
In order to confirm the in vivo effectiveness of anti- feline herpesvirus type 1 (FHV-1) mouse-cat chimeric antibody (FJH2), and anti-feline calicivirus (FCV) mouse-cat chimeric antibody (F1D7), cats that had been experimentally infected with FHV-1 or FCV were administered intravenously with the chimeric antibodies, and observed for clinical manifestations. The symptoms due to FHV-1 or FCV infection in the cats administered FJH2 or F1D7 were obviously decreased when compared with those of the non-administered control cats. From these results, it was confirmed that both FJH2 and F1D7 were effective at reducing the appearance of symptoms due to FHV-1 and FCV infection, respectively.
Umehashi
Misako
M
The Chemo-Sero-Therapeutic Research Institute, Kyokushi Kikuchi, Kumamoto, Japan.
Imamura
Takashi
T
Akiyama
Shunsuke
S
Kimachi
Kazuhiko
K
Tokiyoshi
Sachio
S
Mikami
Takeshi
T
D000818:Animals; D000914:Antibodies, Viral / Q000235:genetics / Q000276:immunology*; D017250:Caliciviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D017927:Calicivirus, Feline / Q000276:immunology* / Q000502:physiology; D002371:Cat Diseases / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D002415:Cats; D005260:Female; D006564:Herpesviridae / Q000276:immunology* / Q000502:physiology; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors
D000914:Antibodies, Viral; D011993:Recombinant Fusion Proteins