Chronic metoclopramide therapy for diabetic gastroparesis.
OBJECTIVE
To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.


METHODS
Medical literature was accessed through MEDLINE (1965 to October 2002) and PubMed (1965 to October 2002). Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced.


RESULTS
Metoclopramide is often used for diabetic gastroparesis, despite the risk of tardive dyskinesia. Published information is limited regarding long-term efficacy and toxicity of metoclopramide. The literature was assessed concerning these topics.


CONCLUSIONS
Limited data do not provide sufficient evidence to conclude whether metoclopramide is efficacious for chronic use. Routine monitoring may mitigate the risk associated with metoclopramide therapy.
Lata
Paul F
PF
Case Management Services, Bay Area Medical Center, Marinette, WI 54143-4242, USA. plata@bamc.org
Pigarelli
Denise L Walbrandt
DL
D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D048909:Diabetes Complications; D004334:Drug Administration Schedule; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008787:Metoclopramide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D000932:Antiemetics; D008787:Metoclopramide