title: CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats.
abstract: Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF.
authors.affiliation: Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl
authors.forename: Petra J G
authors.initials: PJ
authors.lastname: Zwijnenburg
authors.forename: Machteld M J
authors.initials: MM
authors.lastname: Polfliet
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: Timo K
authors.initials: TK
authors.lastname: van den Berg
authors.forename: Christine D
authors.initials: CD
authors.lastname: Dijkstra
authors.forename: Sander J H
authors.initials: SJ
authors.lastname: van Deventer
authors.forename: John J
authors.initials: JJ
authors.lastname: Roord
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
authors.forename: A Marceline
authors.initials: AM
authors.lastname: van Furth
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology; D002490:Central Nervous System / Q000502:physiology*; D054426:Chemokine CXCL2; D019743:Chemokines, CXC / Q000134:cerebrospinal fluid* / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D004357:Drug Synergism; D008297:Male; D015846:Monokines / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D054426:Chemokine CXCL2; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D015846:Monokines