title: No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8.
abstract: The superoxide dismutase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C. elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions.
authors.affiliation: Department of Biology, University College London, London, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Keaney
authors.forename: David
authors.initials: D
authors.lastname: Gems
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D018716:Molecular Mimicry; D009942:Organometallic Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase; D013997:Time Factors
chemical_list: D005029:Ethylenediamines; D009942:Organometallic Compounds; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D013482:Superoxide Dismutase