Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-beta-lactamase VIM-1.
An Escherichia coli strain exhibiting decreased susceptibility to carbapenems was isolated from a hospitalized patient in Greece. The strain carried a self-transferable plasmid coding for metallo-beta-lactamase VIM-1. bla(VIM-1), along with aacA7, dhfrI, and aadA, was included as a gene cassette in a novel class 1 integron. A Citrobacter freundii ampC-derived gene, not associated with the integron, was also located in the same plasmid.
Miriagou
Vivi
V
Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece. miriagou@mail.pasteur.gr
Tzelepi
Eva
E
Gianneli
Dimitra
D
Tzouvelekis
Leonidas S
LS
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D032023:Integrons / Q000235:genetics; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases