Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease.
S100B is a predominantly astrocytic protein with dose-dependent cytotoxic and neurotrophic properties encoded on chromosome 21q22.3. Concentrations of S100B were measured in the cerebrospinal fluid (CSF) of 31 patients with Alzheimer's disease (AD), 36 patients with frontotemporal lobe dementia (FTLD) and 49 patients with other non-inflammatory neurological diseases. Additional CSF S100B concentrations were correlated with normalised brain volume measurements in AD and FTLD. CSF S100B was significantly higher in AD (Mean+/-standard deviation=0.4+/-0.2 ng/ml) and FTLD (0.42+/-0.19 ng/ml) patients when compared with control subjects (0.25+/-0.08, P<0.001). In patients with AD, S100B correlated negatively with normalised brain volume (R(S)=-0.53, P<0.001). No such correlation was found for FTLD patients. This study supports the concept that S100B is of pathological relevance for degeneration of the central nervous system in AD.
Petzold
A
A
Institute of Neurology, Department of Neuroinflammation, Queen Square, London WC1N 3BG, UK. a.petzold@ion.ucl.ac.uk
Jenkins
R
R
Watt
H C
HC
Green
A J E
AJ
Thompson
E J
EJ
Keir
G
G
Fox
N C
NC
Rossor
M N
MN
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000473:pathology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000009:adverse effects* / Q000134:cerebrospinal fluid* / Q000378:metabolism; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D010296:Parietal Lobe / Q000473:pathology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000009:adverse effects* / Q000134:cerebrospinal fluid* / Q000378:metabolism
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human