[Potential antimitotics. 2. Synthesis of 1-benzyl-3-carbethoxy-2-quinolones].
A group of substituted 1-benzyl-3-carbethoxy-2-quinolones, whose design was based on the structures of well established antimitotics, were synthesized by a three reactions sequence. Although the yields of the first reaction (condensation of o-nitrobenzaldehydes with diethyl malonate) could not be improved, the synthetic route turned out quite efficient.
Lorenzo
María A
MA
Laboratorio de Química Medicinal y Síntesis Orgánica, Centro de Química Orgánica, Facultad de Ciencias, Universidad Central de Venezuela.
Guzmán
Wilmer
W
Márquez
Carlos J
CJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D015363:Quinolones