Tick-borne typhus fever of northern Asia: some characteristics of the pathogenesis.
Morphological changes in the viscera of albino mice were studied over the course of North Asia typhus fever. In general, the microcirculatory bed in the studied organs (brain, liver, spleen, peritoneum, and testicle) corresponded to angioparalytical capillary and venular hyperemia. Macrophagic reaction (proliferation of stellate macrophages) transformed into granulomatous reaction in the course of the experiment. Macrophagic reaction of the spleen was characterized by blurred follicular pattern. In the testes a tendency to the loss of normal spermatogenesis was observed.
Nelyubov
M V
MV
Institute of Immunopathology, Russian Academy of Natural Sciences, Moscow, Russia.
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D002196:Capillaries / Q000382:microbiology; D002642:Chick Embryo; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008833:Microcirculation / Q000382:microbiology; D012281:Rickettsia / Q000472:pathogenicity; D012282:Rickettsia Infections / Q000175:diagnosis* / Q000473:pathology; D013154:Spleen / Q000382:microbiology; D013737:Testis / Q000382:microbiology / Q000473:pathology; D017282:Tick-Borne Diseases / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors