Candida parapsilosis keratitis.
OBJECTIVE
To present clinical, microbiologic, and histopathologic features of keratitis due to Candida parapsilosis.


METHODS
Clinicomicrobiologic evaluation of four patients (four eyes) with culture-proven C. parapsilosis keratitis. The patients were evaluated for symptoms, visual acuity, clinical observations, microbiologic examination of corneal scrapings, and pathologic examination of corneal buttons.


RESULTS
Three cases were observed after penetrating keratoplasty, and one case occurred after inhalation of corticosteroids. Clinical presentation of C. parapsilosis keratitis showed a great diversity. There was one case of crystalline keratopathy and three cases of suppurative corneal infiltrate. Histopathology of corneal buttons showed interlamellar accumulations of yeast. Medical treatment included topical amphotericin B and systemic triazoles. Penetrating keratoplasty was required in three patients.


CONCLUSIONS
Risk factors for C. parapsilosis keratitis may include corticosteroid use and prior corneal transplantation. The prognosis of C. parapsilosis keratitis with antifungal and surgical therapy may vary from good visual outcome to intraocular extension with phthisis bulbi.
Bourcier
Tristan
T
Quinze-Vingts National Center of Ophthalmology, Paris, France. bourcier@quinze-vingts.fr
Touzeau
Olivier
O
Thomas
Frédéric
F
Chaumeil
Christine
C
Baudrimont
Marie
M
Borderie
Vincent
V
Laroche
Laurent
L
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000382:microbiology; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D003131:Combined Modality Therapy; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D015948:Keratoplasty, Penetrating; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D014792:Visual Acuity
D000935:Antifungal Agents