Functional analysis of retinal vessel diameter reaction to artificially raised intraocular pressure in glaucoma patients with and without dorzolamide therapy.
BACKGROUND
Examination of the influence of dorzolamide on the autoregulation of retinal vessel diameter in glaucoma patients.


METHODS
Eleven patients with primary open angle glaucoma (age 60 +/- 11) without medication and four weeks after starting therapy with dorzolamid eye drops three times daily were examined in the study. Short-time rise of intraocular pressure (IOP) was obtained via suction-cup. Functional reaction of the diameter of a segment of a retinal artery and corresponding vein were assessed by retinal vessel analyzer.


RESULTS
Dorzolamid lowered the IOP from 23.3 +/- 1.3 to 17.6 +/- 2.2 mmHg (p = 0.004). Therapy did not influence the absolute diameter of retinal vessels regarding maximal dilatation caused by the pressure rising provocation. In eyes with treatment the diameter decreased faster to baseline values (arteries 100 sec, veins 220 sec) compared to those without treatment (arteries 350 sec, veins 480 sec).


CONCLUSIONS
Dorzolamid might possibly be able to accelerate autoregulation of retinal vessels in response to short term artificial IOP increase.
Nagel
E
E
Technical University, Ilmenau, Germany. e_a_nagel@t-online.de
Vilser
W
W
Lanzl
I
I
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005451:Fluorescein Angiography; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000187:drug effects* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D013876:Thiophenes / Q000008:administration & dosage* / Q000009:adverse effects; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D000959:Antihypertensive Agents; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide