title: Chromosome mapping of MHC class I in rainbow trout (Oncorhynchus mykiss).
abstract: The major histocompatibility complex (MHC) is well-studied in mammals. Much research has addressed the genomic organisation of MHC genes and it is well established that human MHC class I genes are located on chromosome 6. However, information on the organisation of the MHC complex in rainbow trout is only beginning to become available. In the present study it was determined that rainbow trout MHC class I sequences are located on chromosome 18. This is the first reported use of fluorescence in situ hybridisation (FISH) to identify the chromosomal location of genes involved in the immune system of fish.
authors.affiliation: Department of Aquatic Biosciences, Tokyo University of Fisheries, Konan 4, Minato-ku, Tokyo, 108-8477, Japan.
authors.forename: Atushi
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Ikunari
authors.initials: I
authors.lastname: Kiryu
authors.forename: Johannes Martinus
authors.initials: JM
authors.lastname: Dijkstra
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Yoshiura
authors.forename: Chizuko
authors.initials: C
authors.lastname: Nishida-Umehara
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ototake
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D005805:Genes, MHC Class I / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000662:veterinary; D017686:Oncorhynchus mykiss / Q000235:genetics* / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I