Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages.
We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.
Nakano
Tetsuji
T
Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan.
Hiramatsu
Kazufumi
K
Kishi
Kenji
K
Hirata
Norio
N
Kadota
Jun-Ichi
J
Nasu
Masaru
M
D000818:Animals; D002981:Clindamycin / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
D016207:Cytokines; D008070:Lipopolysaccharides; D002981:Clindamycin