title: Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia.
abstract: Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect of a pharmacological endogenous bone marrow mobilization in the course of cerebral ischemia and open a new direction for cellular therapy strategy in stroke.
authors.affiliation: EA1046-Laboratoire de Pharmacologie, Faculté de Médecine, Université de Lille 2, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Six
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Gasan
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Mura
authors.forename: Régis
authors.initials: R
authors.lastname: Bordet
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor