title: Fluconazole in the treatment of pediatric tinea capitis caused by Microsporum canis.
abstract: Fluconazole has been shown to be effective in the treatment of fungal scalp infections in children; however, there is limited experience of its use in Microsporum scalp infections. We studied 11 children with tinea capitis caused by Microsporum canis who received oral fluconazole at a dose of 5-7.5 mg/kg/day for 6 weeks. Mycological cure was observed in two of the 11 patients at week 4 from the start of therapy, in four patients at week 8 and in three patients at week 16. One of the remaining patients had positive mycology at week 8, but was unavailable for further evaluation. Fluconazole was effective in treating pediatric tinea capitis caused by Microsporum canis and was well tolerated. Clinical and mycological response was achieved in some patients weeks after the cessation of the administration of fluconazole.
authors.affiliation: Department of Dermatology, A. Sophia Children's Hospital, Goudi 11527, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Valari
authors.forename: A
authors.initials: A
authors.lastname: Iordanidou
authors.forename: A
authors.initials: A
authors.lastname: Raftopoulou
authors.forename: A
authors.initials: A
authors.lastname: Pangalis
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008864:Microsporum / Q000187:drug effects; D014006:Tinea Capitis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D015725:Fluconazole