ECVAM's activities on computer modelling and integrated testing.
This paper introduces the basic concepts of quantitative structure-activity relationship (QSAR), expert system and integrated testing strategy, and explains how the analogy between QSARs and prediction models leads naturally to criteria for the validation of QSARs. ECVAM's in-house research programme on QSAR modelling and integrated testing is summarised, along with plans for the validation of QSAR models and expert system rulebases at the European Union level.
Worth
Andrew P
AP
ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy.
D000826:Animal Testing Alternatives; D000818:Animals; D003198:Computer Simulation; D005062:European Union; D005103:Expert Systems; D006801:Humans; D011237:Predictive Value of Tests; D021281:Quantitative Structure-Activity Relationship; D015203:Reproducibility of Results; D018675:Toxicity Tests / Q000379:methods*; D015262:Xenobiotics / Q000737:chemistry / Q000145:classification
D015262:Xenobiotics