title: Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
abstract: Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
authors.affiliation: Institut für Experimentelle Endokrinologie, Universitätsklinikum Charité, Schumannstrasse 20/21, 10117 Berlin, Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Schomburg
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schweizer
authors.forename: Bettina
authors.initials: B
authors.lastname: Holtmann
authors.forename: Leopold
authors.initials: L
authors.lastname: Flohé
authors.forename: Michael
authors.initials: M
authors.lastname: Sendtner
authors.forename: Josef
authors.initials: J
authors.lastname: Köhrle
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D017353:Gene Deletion; D051379:Mice; D008822:Mice, Transgenic; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism*; D051149:Selenoprotein P; D051140:Selenoproteins
chemical_list: D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D012643:Selenium