[The activity of NAD(P)-dependent dehydrogenases in blood lymphocytes in children and adolescents with different duration of insulin-dependent diabetes mellitus].
The levels of blood lymphocyte NAD(P)-dependent dehydrogenases were investigated in children and teenagers with different duration of insulin-dependent diabetes mellitus (IDDM). The level of some NAD(P)-dependent dehydrogenases changed proportionally in dependence of IDDM duration and insulin therapy did not restore their activities to the normal level. It is suggested that these changes may reflect decrease of energy metabolism and plastic processes in blood lymphocytes from diabetic children and teenagers reflecting. These changes correspond to altered functional reactivity of immunocompetent cells and represent metabolic basis of immunopathogenic complications of IDDM.
Savchenko
A A
AA
Institute for Medical Problems of the North, Siberian Division of Russian Academy of Medical Sciences, Zheleznjak str., 3-G, Krasnoyarsk, 660022, Russia.
Kriukova
E V
EV
Manchuk
V T
VT
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005969:Glutamate Dehydrogenase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008214:Lymphocytes / Q000201:enzymology*; D009252:NADPH Dehydrogenase / Q000097:blood*; D013997:Time Factors
D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005969:Glutamate Dehydrogenase; D009252:NADPH Dehydrogenase; D005980:Glutathione Reductase