title: Comparison of an insulin analog, insulin aspart, and regular human insulin with no insulin in gestational diabetes mellitus.
abstract: OBJECTIVE
  To assess the short-term efficacy of insulin aspart in comparison with regular human insulin in women with gestational diabetes mellitus (GDM) during standardized meal tests.
  
  
  METHODS
  The study included 15 women with GDM who had inadequate diabetes control with diet alone. On 3 consecutive days, breakfast meal tests were performed-the first with no exogenous insulin and the other two after the injection of either regular insulin or insulin aspart.
  
  
  RESULTS
  The peak insulin concentration was higher and the peak glucose and C-peptide concentrations were lower with both insulin preparations than with no exogenous insulin. Glucose areas under the curve above baseline were significantly lower with insulin aspart (180-min area, 7.1 mg. h. dl(-1); P = 0.018), but not with regular insulin (30.2 mg. h. dl(-1); P = 0.997), than with no insulin (29.4 mg. h. dl(-1)).
  
  
  CONCLUSIONS
  This study demonstrates that effective postprandial glycemic control in women with GDM who required insulin was brought about by insulin aspart through higher insulin peak and lower demand on endogenous insulin secretion.
authors.affiliation: Sansum Medical Research Institute, Santa Barbara, California. Novo Nordisk Pharmaceuticals, Inc., Princeton, New Jersey, USA. dpettitt@sansum.org
authors.forename: David J
authors.initials: DJ
authors.lastname: Pettitt
authors.forename: Paulina
authors.initials: P
authors.lastname: Ospina
authors.forename: Jerzey W
authors.initials: JW
authors.lastname: Kolaczynski
authors.forename: Lois
authors.initials: L
authors.lastname: Jovanovic
mesh_terms: D000328:Adult; D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D016640:Diabetes, Gestational / Q000188:drug therapy*; D004435:Eating; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000097:blood; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D061267:Insulin Aspart; D008875:Middle Aged; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D061267:Insulin Aspart