Recurring breakpoints of 1p13 approximately p22 in osteochondroma.
Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors. Surprisingly, three of the chromosome 1 aberrations involved pericentric inversions. Four tumors showed aberrations involving the region 1p13 approximately p22 by mechanisms including inversion, insertion, and translocation. These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13 approximately p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
Sawyer
Jeffrey R
JR
Department of Pathology, University of Arkansas for Medical Sciences, 4301 Markham Street, Little Rock, AR 72205, USA. sawyerjeffreyr@uams.edu
Thomas
Edward L
EL
Lukacs
Janet L
JL
Swanson
Charles M
CM
Ding
Yiling
Y
Parham
David M
DM
Thomas
James R
JR
Nicholas
Richard W
RW
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D019457:Chromosome Breakage / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D015831:Osteochondroma / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics