title: Recurring breakpoints of 1p13 approximately p22 in osteochondroma.
abstract: Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors. Surprisingly, three of the chromosome 1 aberrations involved pericentric inversions. Four tumors showed aberrations involving the region 1p13 approximately p22 by mechanisms including inversion, insertion, and translocation. These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13 approximately p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, 4301 Markham Street, Little Rock, AR 72205, USA. sawyerjeffreyr@uams.edu
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Sawyer
authors.forename: Edward L
authors.initials: EL
authors.lastname: Thomas
authors.forename: Janet L
authors.initials: JL
authors.lastname: Lukacs
authors.forename: Charles M
authors.initials: CM
authors.lastname: Swanson
authors.forename: Yiling
authors.initials: Y
authors.lastname: Ding
authors.forename: David M
authors.initials: DM
authors.lastname: Parham
authors.forename: James R
authors.initials: JR
authors.lastname: Thomas
authors.forename: Richard W
authors.initials: RW
authors.lastname: Nicholas
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D019457:Chromosome Breakage / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D015831:Osteochondroma / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics