[Effect of interventional chemothermotherapy on vascular permeability of tumor liver tissue and normal liver tissue in VX-2 tumor-bearing rabbits].
OBJECTIVE
It was reported that heating could enhance the sensitivity of chemotherapy with Adriamycin and increase the intracellular content of Adriamycin. The aim of this study was to investigate the effect of interventional chemothermotherapy on vascular permeability of tumor liver tissue and normal liver tissue in VX-2 tumor-bearing rabbits.


METHODS
Thirty rabbits used as implanted hepatocarcinoma model were randomly divided into 3 groups: non-perfusion group (injected only with 1% Evans blue after catheterization), normothermic perfusion group (the perfusion fluid was 25 degrees C normal solution), and hyperthermic perfusion group(the perfusion fluid was 60 degrees C normal solution). The contents of Evans blue in the tissues of three groups, which were used as the indices of vascular permeability, were calculated by the standard curve and spectrophotometry.


RESULTS
The Evans blue contents in tumor liver tissue and normal liver tissue is statistically different (P < 0.05). There was no over difference of the Evans blue contents in two kinds of tissue between normal perfusion group and non-perfusion group. There was overt difference of the Evans blue contents in two kinds of tissue between hyperthermic perfusion group and normothermic perfusion group.


CONCLUSIONS
Interventional chemothermotherapy could increase the vascular permeability of normal liver tissue and tumor liver tissue.
Liu
Yan
Y
Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, P. R. China.
Zhang
Hong-xin
HX
Cao
Xiao-ming
XM
Liu
Yi-yong
YY
Li
Wen-xian
WX
Ni
Dai-hui
DH
Cao
Wei
W
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use*; D006979:Hyperthermia, Induced; D008099:Liver / Q000098:blood supply / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D009368:Neoplasm Transplantation; D011817:Rabbits; D011897:Random Allocation; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004317:Doxorubicin