title: Effect on diagnostic efficiency of analgesia for undifferentiated abdominal pain.
abstract: BACKGROUND
  The question of whether it is safe to provide analgesia for patients with undifferentiated acute abdominal pain is marked by longstanding controversy over the possible masking of physical findings. The goal of this review is to assess the pertinent studies.
  
  
  METHODS
  A Medline search was performed in April 2002, using the terms 'analgesia', 'abdominal pain', 'acute abdomen' and 'morphine'. Other articles were identified using the bibliographies of papers found through Medline. All articles reporting clinical trials of analgesia and its effects on diagnosis or physical examination were reviewed.
  
  
  RESULTS
  A total of eight trials (one reported only as an abstract) were identified. Because of significant disparity in trial design, no formal analysis such as meta-analysis was performed. However, detailed review of the trials revealed a striking consistency in results. In no study was there an association between analgesia and diagnostic impairment or dangerous masking of the findings of physical examination.
  
  
  CONCLUSIONS
  The literature addressing early pain relief for abdominal pain is characterized by weaknesses, but there is a common theme suggesting that analgesia is safe. Pending further research, which should address some of the shortcomings of extant studies, a practice of judicious provision of analgesia appears safe, reasonable and in the best interests of patients in pain.
authors.affiliation: Department of Surgery, Harvard medical School, Massachusetts General Hospital, Boston, Massachusetts 02114-2696, USA. Thomas.Stephen@mgh.harvard.edu
authors.forename: S H
authors.initials: SH
authors.lastname: Thomas
authors.forename: W
authors.initials: W
authors.lastname: Silen
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000698:Analgesia / Q000379:methods*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D002648:Child; D006801:Humans; D009020:Morphine / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine