title: Drug-induced hepatitis with hepatic granuloma due to saridon.
abstract: A 38-year-old Japanese woman with no past history of liver disease developed liver dysfunction associated with fever, anorexia, and general malaise following the prolonged administration of saridon. A liver biopsy demonstrated multiple noncaseating epithelioid granulomas within hepatic lobules, with an inflammatory cell infiltrate of the lobular parenchyma and portal tracts. Viral markers and autoantibodies were negative. Lymphocyte stimulation tests for saridon and for isopropylantipyrine, one of the constituents of saridon, were positive, and therefore a diagnosis of drug-induced hepatitis due to administration of saridon was made. Her symptoms resolved and liver function test results returned to normal following discontinuation of the drug. The possibility of drug-induced hepatitis must be considered when liver dysfunction or systemic symptomatology develops during saridon therapy.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamagami
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Kayo
authors.initials: K
authors.lastname: Abe
authors.forename: Izumi
authors.initials: I
authors.lastname: Okura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yamashita
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001707:Biopsy, Needle; D002110:Caffeine / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D006261:Headache / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008111:Liver Function Tests; D010615:Phenacetin / Q000009:adverse effects* / Q000627:therapeutic use; D011728:Pyridones / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D004338:Drug Combinations; D011728:Pyridones; D002110:Caffeine; C019552:Saridon; D010615:Phenacetin; D000983:Antipyrine