title: [Primary pulmonary hypertension arterial and Basedow disease].
abstract: We report a case of a fifty year old woman with Graves' disease with positive AntiTPO antibodies and positive AntiTSH receptor antibodies, who was hospitalized with a right cardiac failure. A pulmonary hypertension was discovered on echocardiography. After adequate antithyroid therapy, the right cardiac failure regressed rapidly and pulmonary pressure normalised. An autoimmune process has often been proposed to explain the association between pulmonary hypertension and hyperthyroidism. We report the arguments supporting this autoimmune etiopathogenesis. We also discuss an other hypothesis based on a direct effect of thyroid hormones on the pulmonary circulation and the effects of high cardiac output associated with hyperthyroidism.
authors.affiliation: Service de Médecine II Hôpital régional, 2900 Porrentruy.
authors.forename: Lise
authors.initials: L
authors.lastname: Piquilloud
authors.forename: Marc-H
authors.initials: MH
authors.lastname: Blanc
authors.forename: Franca
authors.initials: F
authors.lastname: Suvá
authors.forename: Michel
authors.initials: M
authors.lastname: Périat
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D004452:Echocardiography; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies