title: Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients.
abstract: Increased expression of intercellular adhesion molecule 1 (ICAM1), a protein known to contribute to inflammatory responses, has been detected in the brain tissue of patients with Alzheimer's disease (AD) and animals modelled to mimic AD or Parkinson's disease (PD). ICAM1 may, thus, be implicated in the pathogenesis of these disorders. Our purpose was to investigate whether genetic variants of the ICAM1 gene have a role in causing susceptibility to AD and/or PD. We genotyped the E469K polymorphism of ICAM1 in 196 AD, 52 PD and 202 control patients of Finnish origin. The distributions of the genotype and allele frequencies of the polymorphism did not differ significantly between the AD, PD or the control patients. We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD.
authors.affiliation: Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland. kari.m.mattila@uta.fi
authors.forename: Kari M
authors.initials: KM
authors.lastname: Mattila
authors.forename: Mikko
authors.initials: M
authors.lastname: Hiltunen
authors.forename: Juha O
authors.initials: JO
authors.lastname: Rinne
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.forename: Matias
authors.initials: M
authors.lastname: Röyttä
authors.forename: Irina
authors.initials: I
authors.lastname: Alafuzoff
authors.forename: Pekka
authors.initials: P
authors.lastname: Laippala
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D018799:Intercellular Adhesion Molecule-1