title: The Ontario Uterine Fibroid Embolization Trial. Part 1. Baseline patient characteristics, fibroid burden, and impact on life.
abstract: OBJECTIVE
  To determine baseline characteristics of women undergoing uterine artery embolization (UAE) for symptomatic fibroids.
  
  
  METHODS
  Multicenter, prospective, single-arm clinical treatment trial.
  
  
  METHODS
  Eight Ontario university and community hospitals.
  
  
  METHODS
  Five hundred fifty-five women undergoing UAE for fibroids.
  
  
  METHODS
  Baseline questionnaires completed before UAE.
  
  
  METHODS
  Questionnaires were analyzed for demographic, medical, and gynecologic histories. Fibroid symptoms, impact of symptoms, previous consultations, and treatments were also analyzed.
  
  
  RESULTS
  The Ontario cohort (66% white, 23% black, 11% other races) had an average age of 43. Thirty-one percent were under age 40. Most women were university educated (68%) and working outside the home (85%). Women reported heavy menstrual bleeding (80%), urinary urgency/frequency (73%), pain during intercourse (41%), and work absences (40%). They experienced fibroid-related symptoms for an average of 5 years and consulted with on average of three gynecologists before UAE. High fibroid life-impact scores were reported by 58%. Black women were significantly younger (40.7 vs. 44.0 years), more likely to experience symptoms longer (7 vs. 5 years), and more likely to undergo myomectomy before UAE (24% vs. 9%) than white women.
  
  
  CONCLUSIONS
  Our study illustrates that large numbers of women with highly symptomatic fibroid disease are averse to surgery despite their burden of suffering and are actively seeking alternatives to hysterectomy.
authors.affiliation: Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada. g.pron@utoronto.ca
authors.forename: Gaylene
authors.initials: G
authors.lastname: Pron
authors.forename: Marsha
authors.initials: M
authors.lastname: Cohen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Soucie
authors.forename: Greg
authors.initials: G
authors.lastname: Garvin
authors.forename: Leslie
authors.initials: L
authors.lastname: Vanderburgh
authors.forename: Stuart
authors.initials: S
authors.lastname: Bell
mesh_terms: D000293:Adolescent; D000328:Adult; D001158:Arteries; D044383:Black People; D004522:Educational Status; D004621:Embolization, Therapeutic; D004651:Employment; D005260:Female; D006304:Health Status; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000628:therapy*; D008593:Menopause; D008595:Menorrhagia / Q000628:therapy; D008875:Middle Aged; D009864:Ontario; D017699:Pelvic Pain; D011446:Prospective Studies; D011788:Quality of Life; D044469:Racial Groups; D011795:Surveys and Questionnaires; D013997:Time Factors; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy*; D014599:Uterus / Q000098:blood supply