title: Sub-second liquid chromatographic separations by means of shear-driven chromatography.
abstract: Utilizing the concept of shear-driven chromatography, we have been able to realize reversed-phase LC separations in flat rectangular nano-channels coated with a C8 monolayer and being as thin as 100 nm. At this scale, the separation kinetics are strongly enhanced, as is witnessed by the extremely short time (< 0.1 s) needed to separate a mixture of coumarin dyes. The observed plate numbers are still relatively small, because the experiments were conducted in ultra-short columns (< or = 1 mm) and under injection band width-limiting conditions.
authors.affiliation: Department of Chemical Engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. david.clicq@vub.ac.be
authors.forename: D
authors.initials: D
authors.lastname: Clic
authors.forename: N
authors.initials: N
authors.lastname: Vervoort
authors.forename: R
authors.initials: R
authors.lastname: Vounckx
authors.forename: H
authors.initials: H
authors.lastname: Ottevaere
authors.forename: J
authors.initials: J
authors.lastname: Buijs
authors.forename: C
authors.initials: C
authors.lastname: Gooijer
authors.forename: F
authors.initials: F
authors.lastname: Ariese
authors.forename: G V
authors.initials: GV
authors.lastname: Baron
authors.forename: G
authors.initials: G
authors.lastname: Desmet
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*