title: Modes of presentation of chemical neoantigens to the immune system.
abstract: The immune system can interact with small molecular compounds like drugs. Drugs are not only immunogenic because of their chemical reactivity, but also because they may bind in a labile way to MHC-molecules and fit into available T-cell receptors. This seems to be sufficient to stimulate T-cells. Such structural features of a drug have to be considered in the evaluation of drug hypersensitivity reactions and should be taken into account in predictive drug allergy testing.
authors.affiliation: Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, CH-3010 Bern, Switzerland. werner.pichler@insel.ch
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Pichler
mesh_terms: D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006241:Haptens / Q000737:chemistry / Q000276:immunology; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011237:Predictive Value of Tests; D011971:Receptors, Immunologic / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens; D006241:Haptens; D004364:Pharmaceutical Preparations; D011971:Receptors, Immunologic