InterPreTS: protein interaction prediction through tertiary structure.
CONCLUSIONS
InterPreTS (Interaction Prediction through Tertiary Structure) is a web-based version of our method for predicting protein-protein interactions (Aloy and Russell, 2002, PROC: Natl Acad. Sci. USA, 99, 5896-5901). Given a pair of query sequences, we first search for homologues in a database of interacting domains (DBID) of known three-dimensional complex structures. Pairs of sequences homologous to a known interacting pair are scored for how well they preserve the atomic contacts at the interaction interface. InterPreTS includes a useful interface for visualising molecular details of any predicted interaction.


BACKGROUND
http://www.russell.embl.de/interprets.
Aloy
Patrick
P
EMBL, Meyerhofstrasse, 1, D-69117, Heidelberg, Germany. aloy@embl.de
Russell
Robert B
RB
D030562:Databases, Protein; D021621:Imaging, Three-Dimensional / Q000379:methods; D046911:Macromolecular Substances; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D014584:User-Computer Interface
D046911:Macromolecular Substances; D011506:Proteins