Olfactory neuroblastoma. A report of 3 cases.
Olfactory neuroblastoma is a rare malignant tumour, usually diagnosed at advanced stages. We studied 3 patients who were treated at our Institute between 1991 and 1999. One patient presented with a stage A and 2 with a stage B tumour. One patient presented with coma due to inappropriate secretion of antidiuretic hormone associated with a stage B tumour. All 3 patients were treated with complete surgical resection via a lateral rhinotomy approach and postoperative radiotherapy. There was no involvement of the cribriform plate. One patient developed a metachronous regional metastasis and was treated with neck dissection and radiotherapy. All 3 patients are free from recurrence with a follow-up period of 9 years, 18 months and 1 year, respectively. Combination therapy is the cornerstone of treatment for olfactory neuroblastoma. Complete surgical resection is the most important prognostic factor and can be accomplished via lateral rhinotomy for early stage tumours.
Iliades
Theofilos
T
AHEPA Hospital, Medical School, Aristotelian University of Thessaloniki, Greece. tiliades@med.auth.gr
Printza
Athanasia
A
Eleftheriades
Nikolaos
N
Georgios
Kekes
K
Psifidis
Anestis
A
Thomas
Zaramboukas
Z
D000328:Adult; D000368:Aged; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy