title: Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula.
abstract: Phytochemical examination of a Papua New Guinea collection of Lyngbya majuscula resulted in the discovery of wewakazole (1), a novel cyclic dodecapeptide containing an unprecedented six five-membered heterocycles. Multiple NMR experiments and MS/MS data were required to assemble its planar structure because of its extensively signal-overlapped NMR spectra. In particular, a 1D HMBC was utilized to orient a three amino acid fragment that could not be placed by standard spectroscopic methods. [structure--see text]
authors.affiliation: College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Nogle
authors.forename: Brian L
authors.initials: BL
authors.lastname: Marquez
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010219:Papua New Guinea; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification*; D012624:Seaweed / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; C473357:wewakazole