title: Posterior pole tumor update.
abstract: This chapter focuses on the diagnosis and management of choroidal melanoma in light of recent findings from the COMS. Retinoblastoma is emphasized to describe recent trends in primary treatment away from EBRT and toward chemoreduction with local therapy. In addition, vascular and glial tumors of the retina and tumors of the retinal pigment epithelium are described because of the association between these lesions and systemic disease. Recent advances in treatment and genetic testing for these diseases are discussed. Finally, ocular metastasis, intraocular lymphoid tumors, and intraocular leukemia are included because of their importance in determining systemic treatment and prognosis. The chapter gives an overview of important posterior pole tumors and highlights recent developments in the management of each intraocular disease process.
authors.affiliation: Ocular Oncology Unit, Department of Ophthalmology, University of California at San Francisco, Room K-301, Box 0730, 10 Koret Way, San Francisco, CA 94143-0730, USA.
authors.forename: Judy I
authors.initials: JI
authors.lastname: Ou
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Wheeler
authors.forename: Joan M
authors.initials: JM
authors.lastname: O'Brien
mesh_terms: D002830:Choroid Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000628:therapy; D009898:Optic Disk / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000175:diagnosis* / Q000628:therapy; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D012175:Retinoblastoma / Q000175:diagnosis* / Q000628:therapy