title: Hypoglycemic activity of ginseng glycopeptide.
abstract: OBJECTIVE
  To study the hypoglycemic activity of ginseng glycopeptide (GGP).
  
  
  METHODS
  Normal mice or rabbits and alloxan or streptozotocin-induced hyperglycemic rats or mice were used in the study. Blood glucose and liver glycogen levels of the experimental animals during the trial period were analyzed by spectrophotometry with O-toluidine and iodine reagents, respectively.
  
  
  RESULTS
  Significant decreases in blood glucose and liver glycogen levels were induced in a dose-dependent manner after administration of GGP 50, 100, or 200 mg/kg injected ip or sc to normal mice and injected im 30 or 60 mg/kg to normal rabbits. The hypoglycemic activity of GGP lasted for about 16 h, and were examined in both normal animals and hyperglycemic animals.
  
  
  CONCLUSIONS
  GGP injection induced the pronounced decreases in blood glucose and liver glycogen levels in both normal and hyperglycemic animals.
authors.affiliation: Jilin Institute of Natural Medicine, Jilin University, Changchun 130021, China. cctcmwbx@public.cc.jl.cn
authors.forename: Ben-Xiang
authors.initials: BX
authors.lastname: Wang
authors.forename: Qiu-Li
authors.initials: QL
authors.lastname: Zhou
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Cui
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Liu
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikejima
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006020:Glycopeptides / Q000302:isolation & purification / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D006020:Glycopeptides; D007004:Hypoglycemic Agents; D013311:Streptozocin; D000496:Alloxan; D006003:Glycogen