title: Aspergillosis. Pathogenesis, clinical manifestations, and therapy.
abstract: Diseases caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. Clinical manifestations are variable, ranging from allergic to invasive disease, largely depending on the status of the host's immune system. This article focuses on the pathogenesis and clinical manifestations of diseases caused by Aspergillus species, with more detailed discussion on therapy of the most morbid manifestation, invasive aspergillosis.
authors.affiliation: Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, N. D3-100, Seattle, WA 98109, USA. kmarr@fhcrc.org
authors.forename: Kieren A
authors.initials: KA
authors.lastname: Marr
authors.forename: Thomas
authors.initials: T
authors.lastname: Patterson
authors.forename: David
authors.initials: D
authors.lastname: Denning
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D001230:Aspergillus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D001232:Aspergillus fumigatus / Q000472:pathogenicity; D019468:Disease Management; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000276:immunology / Q000628:therapy
chemical_list: D000935:Antifungal Agents