Meningioma presenting with Cushing's syndrome: an unusual clinical presentation.
We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.
Pecori Giraldi
Francesca
F
Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, University of Milan, Italy. fpg@auxologico.it
Terreni
Maria Rosa
MR
Andreotti
Claudia
C
Losa
Marco
M
Lanzi
Roberto
R
Pontiroli
Antonio E
AE
Cavagnini
Francesco
F
D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000473:pathology; D022142:Secretory Vesicles / Q000648:ultrastructure
D003346:Corticotropin-Releasing Hormone