title: [Potential antimitotics. 2. Synthesis of 1-benzyl-3-carbethoxy-2-quinolones].
abstract: A group of substituted 1-benzyl-3-carbethoxy-2-quinolones, whose design was based on the structures of well established antimitotics, were synthesized by a three reactions sequence. Although the yields of the first reaction (condensation of o-nitrobenzaldehydes with diethyl malonate) could not be improved, the synthetic route turned out quite efficient.
authors.affiliation: Laboratorio de Química Medicinal y Síntesis Orgánica, Centro de Química Orgánica, Facultad de Ciencias, Universidad Central de Venezuela.
authors.forename: María A
authors.initials: MA
authors.lastname: Lorenzo
authors.forename: Wilmer
authors.initials: W
authors.lastname: Guzmán
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Márquez
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D015363:Quinolones