Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use.
Synthesis of grafting silane on a hydro soluble cellulose ether (HPMC) was described. In alkaline medium, this derivate is under gel form. With a decrease of the pH, a self-hardening occurs due to the silanol condensation. For potential biomedical use, we described the silated-HPMC synthesis, the gel behavior after steam sterilization and the parameters of the silanol condensation i.e. pH, silane percentage and temperature. Minimum kinetic of the condensation was observed for pH between 5.5 and 6.5. So temperature catalyzed the reaction and the self-hardening speed was increased by silane percentage.
Bourges
Xavier
X
INSERM E 99-03, Laboratoire des Tissus Calcifiés, Faculté de Chirurgie Dentaire, 1 place Alexis Ricordeau, 44042 Nantes, France. xavier.bourges@sante.univ-nantes.fr
Weiss
Pierre
P
Daculsi
Guy
G
Legeay
Gilbert
G
D000818:Animals; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000737:chemistry; D002516:Ceramics; D005782:Gels; D006244:Hardness; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007700:Kinetics; D008422:Materials Testing; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D011208:Powders; D012212:Rheology; D012821:Silanes / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013242:Sterilization; D014783:Viscosity
C403136:3-glycidoxypropyltrimethoxysilane; D018786:Bone Substitutes; D002130:Calcium Phosphates; D005782:Gels; D011208:Powders; D012821:Silanes; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D065347:Hypromellose Derivatives; C485838:calcium phosphate, monobasic, anhydrous; D008747:Methylcellulose; C020243:calcium phosphate; D012964:Sodium; C485829:calcium phosphate, dibasic, anhydrous