title: Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats.
abstract: 1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP). 2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats. 3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP. 4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.
authors.affiliation: Department of Pharmacology 1, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Csongor S
authors.initials: CS
authors.lastname: Abrahám
authors.forename: Noboru
authors.initials: N
authors.lastname: Harada
authors.forename: Mária A
authors.initials: MA
authors.lastname: Deli
authors.forename: Masami
authors.initials: M
authors.lastname: Niwa
mesh_terms: D000418:Albumins / Q000493:pharmacokinetics*; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002199:Capillary Permeability / Q000502:physiology; D005070:Evans Blue / Q000493:pharmacokinetics; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D016548:Prosencephalon / Q000098:blood supply / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020521:Stroke / Q000378:metabolism*
chemical_list: D000418:Albumins; D005070:Evans Blue