title: A guide to drug discovery: Target selection in drug discovery.
abstract: Target selection in drug discovery--defined here as the decision to focus on finding an agent with a particular biological action that is anticipated to have therapeutic utility--is influenced by a complex balance of scientific, medical and strategic considerations. In this article, we provide an introduction to the key issues in target selection and discuss the rationale for decision making.
authors.affiliation: F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070, Basel, Switzerland. jonathan.knowles@roches.com
authors.forename: Jonathan
authors.initials: J
authors.lastname: Knowles
authors.forename: Gianni
authors.initials: G
authors.lastname: Gromo
mesh_terms: D001709:Biotechnology / Q000191:economics / Q000379:methods; D004345:Drug Industry / Q000191:economics / Q000379:methods / Q000639:trends; D019981:Health Care Sector; D006801:Humans; D007880:Legislation, Drug / Q000639:trends; D010600:Pharmacology / Q000191:economics / Q000379:methods*; D011955:Receptors, Drug / Q000187:drug effects
chemical_list: D011955:Receptors, Drug