title: Biosynthesis of the lipophilic side chain in the cyclic hexadepsipeptide antibiotic IC101.
abstract: Antibiotic IC101 is a cyclic hexadepsipeptide having a C(15) lipophilic side chain. The side chain was shown to be synthesized in Streptomyces from acetate, propionate, and 3-methylbutyrate derived from leucine. Thus, the terminal isopentyl structure came from leucine and not from the mevalonate pathway.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan. umezawa@applc.keio.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naganawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kondo
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D005285:Fermentation; D045782:Hemiterpenes; D007930:Leucine / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000737:chemistry / Q000378:metabolism; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D045782:Hemiterpenes; D010421:Pentanoic Acids; D010455:Peptides; D010456:Peptides, Cyclic; C085032:IC 101; C008216:isovaleric acid; D007930:Leucine