[Preconditioning: a general biological phenomenon and its mechanisms].
The present experiments observed the protective effects of ischemic preconditioning (PC) on different organs of rat. It was found that vascular protection of PC is one of the mechanisms of its organ protection. In the cultured neonatal rat (rabbit) cardiomyocytes and vascular smooth muscle cells (VSMC), it was observed that protein kinase C (PKC) activation and PKC-mediated protein phosphorylation were the common chains of PC cytoprotection. Basic fibroblast growth factor could mimic the cytoprotective effects of PC. It is indicated that pharmacological PC might have potential clinical application for ischemic diseases.
Liu
X H
XH
Institute of Cardiovascular Research, Beijing Medical University, Beijing 100083.
D000818:Animals; D019194:Ischemic Preconditioning; D019157:Ischemic Preconditioning, Myocardial; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D015427:Reperfusion Injury / Q000517:prevention & control*
D011493:Protein Kinase C