[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population].
OBJECTIVE
To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to type 2 diabetes in Han people.


METHODS
Genotyping was conducted to investigate the polymorphism of site rs228648 (G-A) in urotensin II gene among 166 unrelated type 2 diabetic subjects (case group 1), 87 probands from 87 families of type 2 diabetics (case group 2), and 121 non-diabetic normal controls (control group).


RESULTS
1) The frequency of "G" allele of site rs228648 was 62.3% and 75.3% in case group 1 and case group 2 respectively, significantly higher than that in the control group (50.4%, P = 0.004 and P < 0.001). 2) The frequency of G/G genotype of rs228648 was 35% and 53% in case group 1 and case group 2 respectively, significantly higher than that in the control group (24%, P < 0.05 and P < 0.01). The odds ratio was 1.86, P = 0.041 in the case group 1 and 4.03, P < 0.001 in the case control 2 after adjustment by sex, age and BMI.


CONCLUSIONS
Urotensin II gene may contribute to the genetic susceptibility to type 2 diabetes in Han population.
Zhu
Fang
F
Department of Endocrinology and Metabolism, People's Hospital of Peking University, Beijing 100044, China.
Ji
Linong
L
Luo
Bin
B
D000328:Adult; D000368:Aged; D002681:China; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015263:Deoxyribonucleases, Type III Site-Specific / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014579:Urotensins / Q000235:genetics*
D014579:Urotensins; D004247:DNA; C029677:urotensin II; C071181:endodeoxyribonuclease Esp3I; D015263:Deoxyribonucleases, Type III Site-Specific