Control in the N-linked glycoprotein biosynthesis pathway.
N-linked glycosylation is vital for the development and maintenance of eukaryotic cells. The individual steps of this complex process are slowly being elucidated. In this issue, the Imperiali group further dissects the mechanics of oligosaccharyl transferase using substrate analogs.
Butters
Terry D
TD
Glycobiology Institute, University of Oxford, South Parks Road, OX1 3QU, Oxford, United Kingdom.
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D006031:Glycosylation; D006602:Hexosyltransferases; D006801:Humans; D008565:Membrane Proteins; D011499:Protein Processing, Post-Translational; D014166:Transferases / Q000378:metabolism
D006023:Glycoproteins; D008565:Membrane Proteins; D014166:Transferases; D006602:Hexosyltransferases; C025620:dolichyl-diphosphooligosaccharide - protein glycotransferase