title: [Correlation and significance of E-cadherin and N-cadherin expression in prostate cancer].
abstract: OBJECTIVE
  Decreased expression of E-Cadherin correlated with many kinds of cancer, but inappropriate expression of N-cadherin has been reported in breast cancer recently, which has a more distinct and direct role in promoting cancer cell motility than E-cadherin. The aim of this study was to investigate the correlation between E-Cadherin and N-Cadherin expression with the grade and stage of prostate cancer and their relationship with prostate specific antigen (PSA).
  
  
  METHODS
  E-Cadherin and N-Cadherin expression in 56 prostate cancer samples were determined by immunohistochemical staining.
  
  
  RESULTS
  Twenty-four patients (43%) were positive and 32 patients (57%) were negative in E-Cadherin expression. Eighteen patients (32%) were negative and 38 patients (68%) were positive in N-Cadherin expression. E-Cadherin and N-Cadherin were significantly related to the grade and stage of cancer and the change of F/T ratio (free prostate specific antigen/total prostate specific antigen ratio). There was no significant relationship between Cadherin expression and total prostate specific antigen (tPSA) or free prostate specific antigen (fPSA).
  
  
  CONCLUSIONS
  E-Cadherin and N-Cadherin abnormal expressions may serve as the indicators to malignant degree and prognosis of the prostate cancer.
authors.affiliation: Department of Urology, First Affiliated Hospital, Pebing University, Beijing 100034, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Zhou
authors.forename: Jun-kui
authors.initials: JK
authors.lastname: Ai
authors.forename: Ying-qian
authors.initials: YQ
authors.lastname: Lu
authors.forename: Yin
authors.initials: Y
authors.lastname: Bai
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Zhi-wen
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Ying-lu
authors.initials: YL
authors.lastname: Guo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D017430:Prostate-Specific Antigen