Autoimmune pancreatitis successfully treated with ursodeoxycholic acid.
A 51-year-old woman with autoimmune pancreatitis is reported in whom treatment with ursodeoxycholic acid (UDCA) was beneficial. Complaining of epigastric discomfort, she presented with liver dysfunction of the cholestatic type, and diabetes mellitus. Pancreatic imaging revealed a diffuse swelling of the body, an irregular narrowing of the main pancreatic duct, and a terminal stricture of the common bile duct. Histologically, the biopsied pancreas was replaced by fibrous tissue with a small amount of mononuclear cell infiltration. She had anti-carbonic anhydrase-II antibody and anti-lactoferrin antibody. After treatment with UDCA, her liver dysfunction and diabetes mellitus improved and the pancreas size was reduced. Steroid therapy is usually indicated for this disorder, but UDCA may be given as an alternative choice.
Tsubakio
Kazumi
K
Department of Internal Medicine, Ashiya Municipal Hospital, Hyogo.
Kiriyama
Kazuo
K
Matsushima
Nobuyoshi
N
Taniguchi
Masahiro
M
Shizusawa
Takae
T
Katoh
Tetsuya
T
Manabe
Noriko
N
Yabu
Michihiro
M
Kanayama
Yoshio
Y
Himeno
Seiichi
S
D000792:Angiography; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001707:Biopsy, Needle; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D005260:Female; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D007159:Immunologic Tests / Q000379:methods; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D014580:Ursodeoxycholic Acid