[Practical control methods for the dose individualization of anticancer drugs].
Most anticancer drugs are characterized by a narrow therapeutic index, wide inter-patient variability of pharmacokinetic parameters and high toxicity. The need for dose individualization of anticancer drugs is now well accepted. The strategies that can be employed for optimizing dosage regimen were reviewed. The aim of this paper was to provide an insight into the feasibility of these techniques in anticancer chemotherapy and their application at all stages of clinical trials and practice.
Wang
Li-yan
LY
Department of Pharmacy, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100021, P. R. China. wly211@hotmail.com
Tang
Zhi-qiang
ZQ
Feng
Feng-yi
FY
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004358:Drug Therapy / Q000379:methods; D006801:Humans
D000970:Antineoplastic Agents