title: [Successful treatment with G-CSF and corticosteroid of adult idiopathic autoimmune neutropenia presenting as recurrent enterocolitis].
abstract: A 63-year-old woman had previously been admitted to another hospital due to fever, abdominal pain and diarrhea. She was treated with fasting, antibiotics and G-CSF administration because of the coexistence of neutropenia, and the symptoms improved. However, discontinuation of G-CSF administration resulted in a recurrence of the neutropenia accompanied with enterocolitis. After admission to our hospital, a diagnosis for idiopathic AIN was performed as she tested positive in both granulocyte immunofluorescence and granulocyte agglutination tests. Administration of corticosteroid following G-CSF resulted in a continuous increase in the neutrophil count and the disappearance of anti-neutrophil autoantibodies.
authors.affiliation: 4th Department of Internal Medicine, Sapporo Medical University School of Medicine.
authors.forename: Akihito
authors.initials: A
authors.lastname: Fujimi
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Rika
authors.initials: R
authors.lastname: Ohnishi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takemoto
authors.forename: Ikuta
authors.initials: I
authors.lastname: Tanaka
authors.forename: Takehide
authors.initials: T
authors.lastname: Akiyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Morii
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terui
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Kogawa
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Michiaki
authors.initials: M
authors.lastname: Hirayama
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohmi
authors.forename: Sumio
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D004760:Enterocolitis / Q000209:etiology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D000893:Anti-Inflammatory Agents; D016179:Granulocyte Colony-Stimulating Factor; D011239:Prednisolone