title: [(123)I]-FP-CIT-SPECT in the early diagnosis of PD presenting as exercise-induced dystonia.
abstract: Isolated foot dystonia following exercise is a rare manifestation of early PD. It may precede the onset of parkinsonism by years and can be clinically indistinguishable from familial exercise-induced dystonia. The authors present a patient with dystonic claudication where dopamine transporter SPECT using (123)I-FP-CIT allowed early diagnosis of PD and enabled effective symptomatic treatment with a dopamine agonist.
authors.affiliation: National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
authors.forename: Regina
authors.initials: R
authors.lastname: Katzenschlager
authors.forename: Durval
authors.initials: D
authors.lastname: Costa
authors.forename: Svetislav
authors.initials: S
authors.lastname: Gacinovic
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D000328:Adult; D050483:Dopamine Plasma Membrane Transport Proteins; D004421:Dystonia / Q000209:etiology*; D004576:Electromyography; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism; D009135:Muscular Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D009419:Nerve Tissue Proteins; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane