title: Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family Polyclinidae.
abstract: Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.(1) The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC(50) value of 9.0 microg/mL.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujita
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005456:Fluorescent Dyes / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000473:Alkanes; D005456:Fluorescent Dyes; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; C473292:sodium 1-(12-hydroxy)octadecanyl sulfate; D019716:Tissue Inhibitor of Metalloproteinase-2