title: Dengue hemorrhagic fever in infants: research opportunities ignored.
abstract: The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue infection. Progress studying the immunologically distinct infant DHF/DSS has been limited; most contemporary research has centered on DHF/DSS accompanying secondary dengue infections. In designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. Research challenges presented by infant DHF/DSS are discussed.
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. halsteads@erols.com
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
authors.forename: Nguyen Trong
authors.initials: NT
authors.lastname: Lan
authors.forename: Thein Thein
authors.initials: TT
authors.lastname: Myint
authors.forename: Than Nu
authors.initials: TN
authors.lastname: Shwe
authors.forename: Ananda
authors.initials: A
authors.lastname: Nisalak
authors.forename: Siripen
authors.initials: S
authors.lastname: Kalyanarooj
authors.forename: Suchitra
authors.initials: S
authors.lastname: Nimmannitya
authors.forename: Soegeng
authors.initials: S
authors.lastname: Soegijanto
authors.forename: David W
authors.initials: DW
authors.lastname: Vaughn
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Endy
mesh_terms: D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007223:Infant; D002052:Myanmar / Q000453:epidemiology; D012106:Research; D019595:Severe Dengue / Q000453:epidemiology*; D013785:Thailand / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology