title: Meningioma presenting with Cushing's syndrome: an unusual clinical presentation.
abstract: We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.
authors.affiliation: Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, University of Milan, Italy. fpg@auxologico.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Pecori Giraldi
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Terreni
authors.forename: Claudia
authors.initials: C
authors.lastname: Andreotti
authors.forename: Marco
authors.initials: M
authors.lastname: Losa
authors.forename: Roberto
authors.initials: R
authors.lastname: Lanzi
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Pontiroli
authors.forename: Francesco
authors.initials: F
authors.lastname: Cavagnini
mesh_terms: D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000473:pathology; D022142:Secretory Vesicles / Q000648:ultrastructure
chemical_list: D003346:Corticotropin-Releasing Hormone