[Tumor angiogenesis in node-negative breast carcinoma].
OBJECTIVE
This study was designed to investigate the vascular endothelial growth factor (VEGF) and the microvessel density(MVD) in node-negative breast carcinoma, and to discuss the relationship of MVD and VEGF to the tumor size, histologic grade, and relapse and metastasis. Meanwhile, the prognostic value of MVD and VEGF was estimated.


METHODS
MVD and VEGF were evaluated after immunohistochemical staining using antibody of vascular endothelium for factor VIII antigen and VEGF in 62 patients with node-negative breast carcinoma respectively. The patients were followed up.


RESULTS
VEGF and MVD were all associated with histological grade and relapse (P < 0.05), but no association with ER and tumorsize; the relapse-free survivals (RFS) and overall survivals of patients with high MVD or high VEGF expression were significantly lower than that of the patients with low MVD or low VEGF expression (P < 0.01). Moreover, the difference of survivals in the patients with high MVD and high VEGF expression were more obvious(P < 0.005). Meanwhile, there was association between MVD and VEGF (P < 0.01).


CONCLUSIONS
The node-negative patients with high VEGF expression or high MVD would have poor prognosis. VEGF and MVD could be significant prognostic indicators for the patients with node-negative breast carcinoma. It has better prognostic value to connected VEGF and MVD. VEGF was an important factor in tumor angiogenesis.
Li
Hong-jiang
HJ
Department of General Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, P. R. China. lihongjiang@sohu.com
Jing
Jing
J
Zhao
Yang-bing
YB
Zhu
Jing-qiang
JQ
Zhang
Shi-yu
SY
Shi
Zong-dao
ZD
D000328:Adult; D001943:Breast Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis; D008207:Lymphatic Metastasis; D008222:Lymphokines / Q000032:analysis; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors