[Relationship between p27 expression and prognosis of colorectal carcinoma].
OBJECTIVE
It has been reported that p27 is associated with prognosis of some tumor. This study was designed to investigate the relationship between expression of p27 and prognosis of colorectal carcinoma.


METHODS
The expression of p27 in 82 colorectal carcinoma specimens was detected by immunohistochemical method. The relationship between the expression of p27 and clinicopathological characteristics or survival time was analyzed by chi 2 test or log rank test, respectively, while univariate and multivariate prognostic analyses were performed by using Cox regression model.


RESULTS
High p27 expression rate in colorectal carcinoma was 53.66% (44/82), while low expression rate was 46.34% (38/82). Low p27 expression in colorectal carcinoma was significantly associated with late Dukes stage, high incidence of lymph metastasis, and distant metastasis. Long rank test showed that the p27 expression was positively correlated to survival time and Cox regression indicated that the p27 was an prognostic marker of colorectal carcinoma.


CONCLUSIONS
Low p27 expression in colorectal carcinoma was significantly associated with late Dukes stage, high incidence of lymph metastasis, and distant metastasis, poor prognosis, and short survival time. p27 is an prognostic marker of colorectal carcinoma.
Chen
Ai-jun
AJ
Department of General Surgery, Yichang Central Hospital, Yichang 443003, P. R. China.
Meng
Qing-hua
QH
Long
Bing
B
Yang
Guo-liang
GL
D000293:Adolescent; D000328:Adult; D000368:Aged; D018797:Cell Cycle Proteins / Q000096:biosynthesis*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27