Possible involvement of neurokinin receptors in CNS and neuromuscular synapse in the realization of the effects of CAPAH and substance P.
Nootropic non-anticholinesterase organophosphorus preparation CAPAH and substance P produced similar and dose-dependent effects on the amplitude and temporal parameters of miniature endplate potentials in mammalian neuromuscular synapse. Neurokinin receptor antagonist Win-51.708 abolished the effects of these agents. In behavioral experiments substance P moderated the mnemotropic and antidepressant effects of CAPAH. It was assumed that neurokinin receptors are the targets of CAPAH and substance P in CNS and neuromuscular synapse.
Semina
I I
II
Kazan State Medical University, Kazan.
Bukharaeva
E A
EA
Shilovskaya
E V
EV
Baichurina
A Z
AZ
Garaev
R S
RS
D000085:Acetates / Q000494:pharmacology*; D000731:Androstanes / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002490:Central Nervous System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D064729:Neurokinin-1 Receptor Antagonists; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013569:Synapses
C115481:2-(chloroethoxy)-p-N-dimethylaminophenylphosphinylacetic acid hydrazide; D000085:Acetates; D000731:Androstanes; D001562:Benzimidazoles; D006834:Hydrazines; D064729:Neurokinin-1 Receptor Antagonists; D009943:Organophosphorus Compounds; D018040:Receptors, Neurokinin-1; C086111:WIN 51708; D013373:Substance P