[Mesenchymal stem cells and related factors].
Mesenchymal stem cells possess the ability to differentiate into osteoblasts, chondroblasts, lipoblasts, myoblasts and so on, which can be used in the formation of hematopoietic microenvironment, tissue repairing and gene therapy. Growth factors such as TGF-beta, IGF-I, BMP and FGF can influence on the differentiation of MSC and they cooperate with each other. MSCs support hematopoiesis by secreting cytokines including G-CSF, SCF, LIF, M-CSF, IL-6, IL-11 and are related to some diseases. MSC would demonstrate important effect on gene engineering.
Wang
Jing
J
Institute of Combined Injury, The Third Military Medical University, Chongqing 400038, China. wj5768@163.net
Luo
Chen-Ji
CJ
Guo
Chao-Hua
CH
Zhang
Yong
Y
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D005818:Genetic Engineering; D006801:Humans; D008648:Mesoderm / Q000166:cytology*; D009103:Multiple Sclerosis / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology; D013234:Stem Cells / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D016207:Cytokines; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors