Influence of dietary methionine level on the liver metallothionein mRNA level in rats.
The effects of some methyl-containing compounds added to a choline-deficient diet on the metallothionein mRNA level in the rat liver were studied. The addition of choline or carnitine to the choline-deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline significantly increased the body weight. The metallothionein mRNA level in the liver of rats fed on the choline-deficient diet was similar to that of rats fed on the choline-deficient diet with choline, betaine or carnitine. However, the addition of methionine to the choline-deficient diet with or without choline caused a marked suppression in the metallothionein mRNA level in the liver. It is thus surmised that the metallothionein mRNA level in the liver might be regulated by the dietary content of methionine.
Nocianitri
Komang Ayu
KA
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Nishi-9, Kita-9, Kita-ku, Sapporo 060-8589, Japan.
Sakakibara
Shoji
S
Kanno
Takashi
T
Kikuchi
Hiroto
H
Kurasaki
Masaaki
M
Aoyama
Yoritaka
Y
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001622:Betaine / Q000378:metabolism; D015152:Blotting, Northern; D001835:Body Weight; D002794:Choline / Q000494:pharmacology; D002796:Choline Deficiency / Q000378:metabolism; D004032:Diet; D008099:Liver / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis* / Q000235:genetics; D008715:Methionine / Q000008:administration & dosage* / Q000378:metabolism; D009929:Organ Size; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D012333:RNA, Messenger; D001622:Betaine; D008668:Metallothionein; D008715:Methionine; D002794:Choline