title: Possible involvement of neurokinin receptors in CNS and neuromuscular synapse in the realization of the effects of CAPAH and substance P.
abstract: Nootropic non-anticholinesterase organophosphorus preparation CAPAH and substance P produced similar and dose-dependent effects on the amplitude and temporal parameters of miniature endplate potentials in mammalian neuromuscular synapse. Neurokinin receptor antagonist Win-51.708 abolished the effects of these agents. In behavioral experiments substance P moderated the mnemotropic and antidepressant effects of CAPAH. It was assumed that neurokinin receptors are the targets of CAPAH and substance P in CNS and neuromuscular synapse.
authors.affiliation: Kazan State Medical University, Kazan.
authors.forename: I I
authors.initials: II
authors.lastname: Semina
authors.forename: E A
authors.initials: EA
authors.lastname: Bukharaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Shilovskaya
authors.forename: A Z
authors.initials: AZ
authors.lastname: Baichurina
authors.forename: R S
authors.initials: RS
authors.lastname: Garaev
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000731:Androstanes / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002490:Central Nervous System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D064729:Neurokinin-1 Receptor Antagonists; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013569:Synapses
chemical_list: C115481:2-(chloroethoxy)-p-N-dimethylaminophenylphosphinylacetic acid hydrazide; D000085:Acetates; D000731:Androstanes; D001562:Benzimidazoles; D006834:Hydrazines; D064729:Neurokinin-1 Receptor Antagonists; D009943:Organophosphorus Compounds; D018040:Receptors, Neurokinin-1; C086111:WIN 51708; D013373:Substance P