title: Stereoselective pharmacokinetics of amlodipine in elderly hypertensive patients.
abstract: Amlodipine is a dihydropyridine calcium antagonist and is widely used for the treatment of cardiovascular diseases. Amlodipine has two stereoisomers [R(+), S(-)], and only the S(-) isomer exerts vasodilating action. In this preliminary study, amlodipine (5 mg) was given to three elderly hypertensive patients once daily for 10 days. Blood samples were obtained, and serum concentrations of R(+)- and S(-)-amlodipine were measured by a gas chromatographic method. The R(+)/S(-) ratio of plasma amlodipine in these elderly subjects was greater than that reported in young subjects. These results suggest that the influence of aging on the pharmacokinetic profiles might differ between the R(+)- and S(-)-isomers of amlodipine.
authors.affiliation: Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Ohmori
authors.forename: Masashi
authors.initials: M
authors.lastname: Arakawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Harada
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takasaki
authors.forename: Senshu
authors.initials: S
authors.lastname: Hifumi
authors.forename: Isamu
authors.initials: I
authors.lastname: Miyamori
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D013237:Stereoisomerism
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine