title: The role of nitric oxide and lipid peroxidation in patients with Plasmodium vivax malaria.
abstract: In this study, we investigated the role of nitric oxide metabolism and lipid peroxidation in patients with P. vivax malaria. The levels of nitrite and nitrate were analyzed using a procedure based on the Griess reaction and malondialdehyde levels which index of lipid peroxidation was determined by thiobarbituric acid reaction. The levels of nitrite/nitrate and malondialdehyde in patients were higher than controls and found to be statistically significant (p < 0.001). We performed this study to determine whether nitric oxide and lipid peroxidation is produced during blood-stage P. vivax malaria. This present study shows that lipid peroxidation occurs in P. vivax malaria. The levels of nitric oxide are associated with lipid peroxidation in this disease.
authors.affiliation: Mersin University, Medical Faculty, Department of Biochemistry, Mersin, Turkey. gurbuzp@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Polat
authors.forename: G
authors.initials: G
authors.lastname: Aslan
authors.forename: G H
authors.initials: GH
authors.lastname: Eskandari
authors.forename: N
authors.initials: N
authors.lastname: Delialioğlu
authors.forename: O
authors.initials: O
authors.lastname: Bağdatoğlu
authors.forename: U
authors.initials: U
authors.lastname: Atik
mesh_terms: D000818:Animals; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D016780:Malaria, Vivax / Q000097:blood / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000502:physiology*; D009573:Nitrites / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D008315:Malondialdehyde