title: Brain natriuretic peptide and HIV-related cardiomyopathy.
abstract: The brain natriuretic peptide (BNP) assay is a new, relatively inexpensive, and simple test that has the potential to be an early, cost-effective, and reliable marker for HIV-related cardiomyopathy. We report 1 case of HIV-related cardiomyopathy and 10 cases of of HIV infection with unknown heart disease in which we measured BNP levels and performed echocardiography. We found a significant inverse relationship between BNP and left ventricular function in these patients. Further basic and epidemiologic research on BNP measurement for the detection of HIV-related cardiomyopathy is needed to support these findings, which if confirmed, could have important clinical and public health implications.
authors.affiliation: Division of Cardiology, Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Carrillo-Jimenez
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Treadwell
authors.forename: Harvey
authors.initials: H
authors.lastname: Goldfine
authors.forename: Alvaro
authors.initials: A
authors.lastname: Buenano
authors.forename: Gervasio A
authors.initials: GA
authors.lastname: Lamas
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hennekens
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain