title: Architectural changes in the developing human brain based on the matrix cell theory.
abstract: Architectural changes in the developing human brain are discussed based on the matrix cell theory. Neural stem cells/matrix cells with self-renewing ability and multipotency exist in the developing human brain in vivo. The brain development is divided into three stages and the cell differentiation is time regulated. Immunohistochemical distribution of various markers for brain development is summarized and categorized along with differentiation lineages. Particularly, the existence of glial fibrillary acidic protein is re-evaluated in the developing human brain. The commonly used terms and concepts "radial glial fiber" or "subventricular zone" are also re-evaluated.
authors.affiliation: Department of Pathology, St. Mary's Hospital, Kurume 830-8543, Japan. naka@st-mary-med.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D015415:Biomarkers; D001921:Brain / Q000166:cytology / Q000196:embryology*; D006801:Humans; D007150:Immunohistochemistry; D008938:Mitosis / Q000502:physiology; D013234:Stem Cells / Q000502:physiology
chemical_list: D015415:Biomarkers