title: The Na+/Ca2+ exchange molecule: an overview.
abstract: An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.
authors.affiliation: Department of Physiology and Cardiovascular Research Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA. kphilipson@mednet.ucla.edu
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Philipson
authors.forename: Debora A
authors.initials: DA
authors.lastname: Nicoll
authors.forename: Michela
authors.initials: M
authors.lastname: Ottolia
authors.forename: Beate D
authors.initials: BD
authors.lastname: Quednau
authors.forename: Hannes
authors.initials: H
authors.lastname: Reuter
authors.forename: Scott
authors.initials: S
authors.lastname: John
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qiu
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000502:physiology; D006321:Heart / Q000502:physiology; D007668:Kidney / Q000502:physiology; D008958:Models, Molecular; D009928:Organ Specificity; D011487:Protein Conformation; D019831:Sodium-Calcium Exchanger / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D019831:Sodium-Calcium Exchanger