Leptin inhibits food intake without affecting brain NOx levels in food-deprived mice.
Effects of leptin on food intake and nitric oxide (NO) metabolites (nitrite and nitrate, NOx) levels of brain were investigated in mice. Leptin dose-dependently decreased milk intake in food-deprived mice. Administration of leptin at a dose of 1 mg/kg, which induces an apparent hypophagia, did not affect NOx levels in the hypothalamus and frontal cortex. These results suggest that leptin reduces food intake in food-deprived mice without altering NO production in the hypothalamus, which plays an important role in regulation of feeding.
Sugimoto
Yumi
Y
Department of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. yumisugi@kobepharma-u.ac.jp
Hirose
Hiroshi
H
Yagura
Tatsuo
T
Yamada
Jun
J
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D020738:Leptin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism
D020738:Leptin; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide