title: Clinical issues surrounding once-daily aminoglycoside dosing in children.
abstract: Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8-12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once-daily regimens. Despite many studies in the adult population, this approach has yet to become standard practice in most pediatric hospitals. Reasons for lack of acceptance of this strategy in children include rapid aminoglycoside clearance, unknown duration of postantibiotic effect, safety concerns, and limited clinical and efficacy data.
authors.affiliation: Department of Pharmacy Services, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA. cknoderer@clarian.org
authors.forename: Chad A
authors.initials: CA
authors.lastname: Knoderer
authors.forename: Julie A
authors.initials: JA
authors.lastname: Everett
authors.forename: William F
authors.initials: WF
authors.lastname: Buss
mesh_terms: D000293:Adolescent; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007223:Infant; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents