One-pot synthesis of tropinone by tandem (domino) ene-type reactions of acetone silyl enol ethers.
A synthetic approach for tropane alkaloids on the basis of tandem (domino) ene-type reactions of acetone silyl enol ethers with iminium ions is shown to be triggered by intermolecular ene-type reactions followed by 6-(2,5) silatropic ene-type cyclizations.
Mikami
Koichi
K
Department of Applied Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8552, Japan. kmikami@o.cc.titech.ac.jp
Ohmura
Hirofumi
H