title: ERK1/2 phosphorylation: a biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006.
authors.affiliation: Universitätsklinikum Essen, Innere Klinik und Poliklinik (Tumorforschung), Abteilung Pharmakologie Antineoplasticher Substanzen, Essen, Germany.
authors.forename: R A
authors.initials: RA
authors.lastname: Hilger
authors.forename: S
authors.initials: S
authors.lastname: Kredke
authors.forename: D
authors.initials: D
authors.lastname: Hedley
authors.forename: J G
authors.initials: JG
authors.lastname: Moeller
authors.forename: R J
authors.initials: RJ
authors.lastname: Bauer
authors.forename: W
authors.initials: W
authors.lastname: Stellberg
authors.forename: S
authors.initials: S
authors.lastname: Seeber
authors.forename: M E
authors.initials: ME
authors.lastname: Scheulen
authors.forename: D
authors.initials: D
authors.lastname: Strumberg
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D010766:Phosphorylation; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D000077157:Sorafenib
chemical_list: D001557:Benzenesulfonates; D015415:Biomarkers; D004791:Enzyme Inhibitors; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib; D019908:Proto-Oncogene Proteins c-raf; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases