Regulation of septation and cytokinesis during resumption of cell division requires uvi31+, a UV-inducible gene of fission yeast.
uvi31+ is a sequence homolog of Escherichia coli bolA gene in Schizosaccharomyces pombe, identified as a UV-inducible gene. Here, the cellular function of uvi31+ was investigated by null mutant analysis. Deletion of uvi31+ led to a delayed germination of spore and defects in subsequent cell division. However, the uvi31 mutant cell proliferated faster with smaller cell size than the wild-type cell during vegetative growth. In addition, the uvi31 mutant was sensitive to UV-light. It showed a normal cell cycle delay after UV-irradiation but displayed aberrant septum formation and defective cytokinesis when released from the UV damage checkpoint. These results suggest that uvi31+ may be involved in control of cell division, especially during the resumption from cell cycle arrest.
Kim
Min Ji
MJ
School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
Kim
Hyun Soo
HS
Lee
Joon Kyu
JK
Lee
Chun Bok
CB
Park
Sang Dai
SD
D002453:Cell Cycle; D002455:Cell Division / Q000502:physiology* / Q000528:radiation effects; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D010641:Phenotype; D012568:Schizosaccharomyces / Q000502:physiology* / Q000528:radiation effects; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000502:physiology*; D013172:Spores, Fungal / Q000235:genetics*; D014158:Transcription, Genetic / Q000528:radiation effects; D014466:Ultraviolet Rays
D029702:Schizosaccharomyces pombe Proteins