The preparation of a fully differentiated "multiwarhead" siderophore precursor.
A protected, fully differentiated siderophore analogue has been prepared so that "Trojan Horse"-like siderophore drug conjugates with different drugs can be synthesized. The key steps in the synthesis include controlled preparation of an unsymmetrical urea and its conversion to a fully differentiated isocyanurate by reaction with chloro(carbonyl) isocyanate.
Murray
Aaron P
AP
University of Notre Dame, Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, USA.
Miller
Marvin J
MJ
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D017262:Siderophores / Q000138:chemical synthesis*; D014508:Urea / Q000737:chemistry
D007202:Indicators and Reagents; D017262:Siderophores; D014508:Urea