title: A paradigm for biological sulfur transfers via persulfide groups: a persulfide-disulfide-thiol cycle in 4-thiouridine biosynthesis.
abstract: In support of the key features of sulfur transfer in the proposed mechanisms of 4-thiouridine generation, the enzyme ThiI can turn over only once in the absence of reductants of disulfide bonds, and Cys-456 of ThiI receives the sulfur transferred from the persulfide group of the sulfurtransferase IscS.
authors.affiliation: Department of Chemistry & Biochemistry, University of fn2Delaware, Newark, Delaware 19716, USA.
authors.forename: Chapman M
authors.initials: CM
authors.lastname: Wright
authors.forename: Peter M
authors.initials: PM
authors.lastname: Palenchar
authors.forename: Eugene G
authors.initials: EG
authors.lastname: Mueller
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D013891:Thiouridine / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds; D013440:Sulfides; C051552:persulfides; D013891:Thiouridine; D013455:Sulfur