Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis.
We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p = 0.015 and p = 0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p = 0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.
Prefumo
Federico
F
UO di Ostetricia e Ginecologia, Instituto G Gaslini, Università di Genova, Italy.
Venturini
Pier Luigi
PL
Fulcheri
Ezio
E
D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D004715:Endometriosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology