title: Pseudodementia associated with use of ibuprofen.
abstract: OBJECTIVE
  To report a case of dementing syndrome resulting from ibuprofen use.
  
  
  METHODS
  A 76-year-old white man with normal mental status became confused, was lost in familiar places, and showed short-term memory loss after beginning a therapeutic regimen of ibuprofen 600 mg 3 times daily for osteoarthritis in anticipation of embarking on a foreign trip. Symptoms of dementia began within 1 week after taking ibuprofen and resolved completely within 1 week after the ibuprofen regimen was stopped. This pattern was repeated 6 months later, when the patient again traveled abroad. Consistently before, during, and after these events, the patient took atenolol, clonidine, lisinopril, aspirin, vitamin C, lecithin, vitamin E, and multivitamins.
  
  
  CONCLUSIONS
  Using the Naranjo probability scale, we reasoned that the patient's dementia-like syndrome could be attributed to the use of ibuprofen because pseudodementia appeared after the suspected drug was administered, improved when the drug was discontinued, reappeared when the drug was readministered, had no apparent alternative cause, manifested similarly after each exposure to ibuprofen, and was confirmed by the family's observation after both episodes. Objective causality assessment revealed that the adverse drug reaction was probable.
  
  
  CONCLUSIONS
  Use of ibuprofen must be considered during clinical evaluation of any patient with new onset of dementing illness. The Naranjo probability scale may be clinically useful for evaluating other pharmaceutical agents that may be contributing to development of dementia-like conditions.
authors.affiliation: Memory Disorder Program, Department of Neurology, Kaiser Permanente Medical Center, Santa Rosa, CA 95403-2192, USA. Allan.L.Bernstein@kp.org
authors.forename: Allan L
authors.initials: AL
authors.lastname: Bernstein
authors.forename: Ann
authors.initials: A
authors.lastname: Werlin
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D005162:Factitious Disorders / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen