title: [Th1 lymphocytes in patients with extrinsic asthma].
abstract: BACKGROUND
  Bronchial asthma is a multifactorial disease affecting the functionality of the bronchial tree and immunological changes.
  
  
  OBJECTIVE
  To determine if lymphocytes Th-1 have a role in extrinsic asthma of Mexican patients.
  
  
  METHODS
  We included in the study 39 patients with extrinsic asthma, living in Mexico City, and 27 healthy subjects, without allergy antecedents, with nutritional and immunological characteristics similar. It was determined the following data: production of IL-2 (in 5 patients and 5 controls), its receptor (in all participants), IFN-g (in 8 patients and 5 controls), and TNF-a (in 8 patients and 5 controls).
  
  
  RESULTS
  Values of IL-2, its receptor and IFN-gamma were higher in patients than in controls, with significant differences. There were not important differences about TNF-alpha.
  
  
  CONCLUSIONS
  Even causes of action change between lymphocytes Th-1 and Th-2 are not known, it is confirmed the moving from Th-2 to Th-1 as an active phenomenon in asthma.
authors.affiliation: Servicio de Alergia e Inmunología Clínica del Hospital Juárez de México, SS. primo65@prodigy.net.mx
authors.forename: Daniel
authors.initials: D
authors.lastname: Aguilar Angeles
authors.forename: Ernestina
authors.initials: E
authors.lastname: Serrano
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada Parra
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Rojo Gutiérrez
authors.forename: Mario Alberto
authors.initials: MA
authors.lastname: Bermejo Guevara
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma