title: [Polymorphism of ACE gene and its relationship with serum ACE activity in the Hans in Chengdu region].
abstract: This study was aimed at the angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism distribution in Chinese and its relationship with serum ACE activity(SACE). SACE activity and ACE gene polymorphism in 90 healthy persons in Chengdu region were investigated using a spectrophotometric assay and the PCR technique, respectively. The results showed that, in the Hans, DD genotype of ACE gene was 18%, DI genotype 44%, and II genotype 38%. Allele frequencies were 0.40 for the D allele and 0.60 for the I allele. There were significant relationships between ACE I/D polymorphism and SACE activity. The results suggest that ACE genotype distribution be different between races, that II genotype and I allele be more frequent in Chinese, and that SACE activity be under the influence of a genetic polymorphism of ACE in Chinese.
authors.affiliation: Department of Gerontology, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Qu
authors.forename: Q
authors.initials: Q
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Deng
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A