X-ray absorption spectroscopy of low-molar-mass metallic complexes in pharmacy.
X-ray absorption spectroscopy provides valuable information on metallic speciation and so has a wide range of applications in bioinorganic systems. In this paper, low-molar-mass metallic complexes as used in pharmaceutical science are focused on. The results of structural studies on metal-based drugs applied as disease treatments, nutritional supplements or tools for diagnostic methods are presented. Then metal speciation (spatial and chemical distribution) in biological samples through micro-XANES imaging experiments are dealt with. Problems arising from the analysis of noisy data collected from these diluted samples are discussed.
Nicolis
Ioannis
I
Laboratoire de Biomathématique, Faculté de Pharmacie, Université Paris V, France. nicolis@pharmacie.univ-paris5.fr
Curis
Emmanuel
E
Deschamps
Patrick
P
Bénazeth
Simone
S
D015502:Absorptiometry, Photon / Q000379:methods; D000596:Amino Acids / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry; D003287:Contrast Media; D019587:Dietary Supplements; D006801:Humans; D008630:Mercury Poisoning; D008670:Metals / Q000737:chemistry* / Q000633:toxicity; D009942:Organometallic Compounds / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D013816:Thermodynamics
D000596:Amino Acids; D003287:Contrast Media; D008670:Metals; D009942:Organometallic Compounds; D004364:Pharmaceutical Preparations; D019275:Radiopharmaceuticals; D002945:Cisplatin