Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine-butorphanol, and dexmedetomidine-ketamine in cats.
OBJECTIVE
To determine sedative and cardiorespiratory effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats.


METHODS
Randomized crossover study.


METHODS
6 healthy adult cats.


METHODS
Cats were given dexmedetomidine alone (10 microg/kg [4.5 mg/lb], IM), a combination of dexmedetomidine (10 microg/kg, IM) and butorphanol (0.2 mg/kg [0.09 mg/lb], IM), or a combination of dexmedetomidine (10 microg/kg, IM) and ketamine (5 mg/kg [2.3 mg/lb], IM). Treatments were administered in random order, with > or = 1 week between treatments. Physiologic variables were assessed before and after drug administration. Time to lateral recumbency, duration of lateral recumbency, time to sternal recumbency, time to recovery from sedation, and subjective evaluation of sedation, muscle relaxation, and auditory response were assessed.


RESULTS
Each treatment resulted in adequate sedation; time to lateral recumbency, duration of lateral recumbency, and time to recovery from sedation were similar among treatments. Time to sternal recumbency was significantly greater after administration of dexmedetomidine-ketamine. Heart rate decreased significantly after each treatment; however, the decrease was more pronounced after administration of dexmedetomidine-butorphanol, compared with that following the other treatments. Systolic and diastolic blood pressure measurements decreased significantly from baseline with all treatments; 50 minutes after drug administration, mean blood pressure differed significantly from baseline only when cats received dexmedetomidine and butorphanol.


CONCLUSIONS
Results suggested that in cats, administration of dexmedetomidine combined with butorphanol or ketamine resulted in more adequate sedation, without clinically important cardiovascular effects, than was achieved with dexmedetomidine alone.
Selmi
André L
AL
Veterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasilia, Brasilia, DF 70910-970, Brazil.
Mendes
Guilherme M
GM
Lins
Bruno T
BT
Figueiredo
Juliana P E
JP
Barbudo-Selmi
Glenda R
GR
D000778:Anesthetics, Dissociative / Q000494:pharmacology; D000818:Animals; D002077:Butorphanol / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats / Q000502:physiology*; D018592:Cross-Over Studies; D020927:Dexmedetomidine / Q000494:pharmacology*; D004338:Drug Combinations; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D000778:Anesthetics, Dissociative; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D007649:Ketamine; D002077:Butorphanol