The Na+/Ca2+ exchange molecule: an overview.
An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.
Philipson
Kenneth D
KD
Department of Physiology and Cardiovascular Research Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA. kphilipson@mednet.ucla.edu
Nicoll
Debora A
DA
Ottolia
Michela
M
Quednau
Beate D
BD
Reuter
Hannes
H
John
Scott
S
Qiu
Zhiyong
Z
D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000502:physiology; D006321:Heart / Q000502:physiology; D007668:Kidney / Q000502:physiology; D008958:Models, Molecular; D009928:Organ Specificity; D011487:Protein Conformation; D019831:Sodium-Calcium Exchanger / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D019831:Sodium-Calcium Exchanger