Effect of intravenous propranolol on left ventricular apical ballooning without coronary artery stenosis (ampulla cardiomyopathy): three cases.
The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called 'takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did not have any intraventricular pressure gradients showed no improvement in the electrocardiographic and left ventricular wall motion abnormalities, the other 2 patients, who had significant intraventricular pressure gradients, did show improvement. Dynamic intraventricular obstruction might play a role in maintaining apical ballooning, at least, in patients exhibiting an intraventricular pressure gradient.
Kyuma
Michifumi
M
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan. kyuma@sapmed.ac.jp
Tsuchihashi
Kazufumi
K
Shinshi
Yasuyuki
Y
Hase
Mamoru
M
Nakata
Tomoaki
T
Ooiwa
Hitoshi
H
Abiru
Masayoshi
M
Hikita
Nobuichi
N
Adachi
Tateo
T
Shoji
Tetsuro
T
Fujise
Yukiyasu
Y
Shimamoto
Kazuaki
K
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001794:Blood Pressure; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage*; D011859:Radiography; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D011433:Propranolol