title: Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
abstract: Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.
authors.affiliation: Department of Experimental and Clinical Pharmacology, The University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, USA.
authors.forename: Brent W
authors.initials: BW
authors.lastname: Gunderson
authors.forename: Khalid H
authors.initials: KH
authors.lastname: Ibrahim
authors.forename: Charles A
authors.initials: CA
authors.lastname: Peloquin
authors.forename: Laurie B
authors.initials: LB
authors.lastname: Hovde
authors.forename: John C
authors.initials: JC
authors.lastname: Rotschafer
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D015308:Anaerobic Threshold / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects*; D006207:Half-Life; D000069349:Linezolid; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid