title: Halonal is a phenobarbital inductor of the monooxygenase system.
abstract: Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.
authors.affiliation: Department of Pharmacology, Siberian State Medical University, Tomsk.
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
authors.forename: T P
authors.initials: TP
authors.lastname: Novozheeva
authors.forename: R R
authors.initials: RR
authors.lastname: Akhmedzhanov
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
chemical_list: D001463:Barbiturates; D006993:Hypnotics and Sedatives; C062695:halonal; D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen; D010634:Phenobarbital