A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease.
A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes. Complement activation is one of the cardinal pathological features of the inflammation. Intensive AD association studies investigating polymorphisms in inflammatory-related genes have been recently performed, mainly in cytokines, but much less has been focused on AD association with polymorphisms in complement components. We performed a case-control association study between the codon 135 polymorphism in the complement component C1r gene and sporadic AD. No association was detected with AD: neither as a risk factor, and nor as a modifier gene affecting the age at disease onset and disease progression. No interactive effect was found with apolipoprotein E e4. These findings show no evidence for association between C1r codon 135 polymorphism and AD in our population.
Rosenmann
Hanna
H
The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel. rosenman@hadassah.org.il
Meiner
Zeev
Z
Kahana
Esther
E
Aladjem
Zoja
Z
Friedman
Gideon
G
Ben-Yehuda
Arie
A
Grenader
Tal
T
Wertman
Eli
E
Abramsky
Oded
O
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003167:Complement Activation / Q000235:genetics*; D015923:Complement C1r / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D005838:Genotype; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013223:Statistics as Topic
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015923:Complement C1r