title: Acetylcholinesterase inhibitors from the roots of Angelica dahurica.
abstract: In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 microM, respectively.
authors.affiliation: College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
authors.forename: Jong Pil
authors.initials: JP
authors.lastname: Lim
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Eom
authors.forename: Jae Soon
authors.initials: JS
authors.lastname: Eun
authors.forename: Kang Hyun
authors.initials: KH
authors.lastname: Leem
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase