Parc-ing p53 in the cytoplasm.
Nikolaev et al. (this issue of Cell) report the identification of a parkin-like protein, Parc, and its role in anchoring the tumor suppressor protein p53 in the cytoplasm reveals yet another level of control of p53 function. Regulation of the subcellular localization of p53 by Parc may serve as a novel target in treatment of certain types of tumors.
Kastan
Michael B
MB
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zambetti
Gerard P
GP
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001692:Biological Transport; D001943:Breast Neoplasms / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism* / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008025:Ligases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D009447:Neuroblastoma / Q000378:metabolism; D009687:Nuclear Proteins; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism
D002352:Carrier Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D014452:Ubiquitins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases