title: Gamma knife radiosurgery in patients with advanced breast cancer undergoing bone marrow transplant.
abstract: OBJECTIVE
  Recent studies have suggested a high incidence of cognitive deficits in patients undergoing high-dose chemotherapy, which appears to be dose related. Whole-brain radiotherapy (WBRT) has previously been associated with cognitive impairment. The authors attempted to use gamma knife radiosurgery (GKS) to delay or avoid WBRT in patients with advanced breast cancer treated with high-dose chemotherapy and autologous bone marrow transplantation (HDC/ABMT) in whom brain metastases were diagnosed.
  
  
  METHODS
  A retrospective review of our experience from 1996 to 2001 was performed to identify patients who underwent HDC/ABMT for advanced breast cancer and brain metastasis. They were able to conduct GKS as initial management to avoid or delay WBRT in 12 patients following HDC/ABMT. All patients were women. The median age was 48 years (range 30-58 years). The Karnofsky Performance Scale score was 70 (range 60-90). All lesions were treated with a median prescription dose of 17 Gy (range 15-18 Gy) prescribed to the 50% isodose. Median survival was 11.5 months. Five patients (42%) had no evidence of central nervous system disease progression and no further treatment was given. Four patients were retreated with GKS and three of them eventually received WBRT as well. Two patients were treated with WBRT as the primary salvage therapy. The median time to retreatment with WBRT was 8 months after the initial GKS.
  
  
  CONCLUSIONS
  Gamma knife radiosurgery can be effectively used for the initial management of brain metastases to avoid or delay WBRT in patients treated previously with HDC, with acceptable survival and preserved cognitive function.
authors.affiliation: Department of Radiation Oncology, Karmanos Cancer Institute and Wayne State University, Detroit, Michigan 48201, USA. levink@karmanos.org
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Levin
authors.forename: Emad F
authors.initials: EF
authors.lastname: Youssef
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Sloan
authors.forename: Rajiv
authors.initials: R
authors.lastname: Patel
authors.forename: Rana K
authors.initials: RK
authors.lastname: Zabad
authors.forename: Lucia
authors.initials: L
authors.lastname: Zamorano
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D003071:Cognition; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D016879:Salvage Therapy