CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats.
Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF.
Zwijnenburg
Petra J G
PJ
Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl
Polfliet
Machteld M J
MM
Florquin
Sandrine
S
van den Berg
Timo K
TK
Dijkstra
Christine D
CD
van Deventer
Sander J H
SJ
Roord
John J
JJ
van der Poll
Tom
T
van Furth
A Marceline
AM
D000818:Animals; D001921:Brain / Q000166:cytology; D002490:Central Nervous System / Q000502:physiology*; D054426:Chemokine CXCL2; D019743:Chemokines, CXC / Q000134:cerebrospinal fluid* / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D004357:Drug Synergism; D008297:Male; D015846:Monokines / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D054426:Chemokine CXCL2; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D015846:Monokines