Current Insights in Whipple's Disease.
Therapy for Whipple's disease should be continued for a minimum of 1 year, and the regimen should include an agent or agents that achieve acceptable concentrations in the central nervous system, given the likelihood of recurrence at this site. Clinical follow-up of proven cases of Whipple's disease should be conducted for a minimum of 10 years after discontinuation of therapy, given the potential for late relapses. Polymerase chain reaction analysis is preferred rather than endoscopy when evaluating for disease recurrence.
Flemmer
Mark C.
MC
Department of Internal Medicine, Eastern Virginia Medical School, Hofheimer Hall, 825 Fairfax Avenue, Norfolk, VA 23507-1912, USA. Flemmemc@evms.edu
Flenner
Ronald W.
RW