[Mechanism of the serotonin effect on motility of the duodenum, ileum, and jejunum in awake rabbits].
I. v. administration of serotonin to alert rabbits produced a phasic change of contractile activity of duodenum, ileum, and jejunum including excitatory and inhibitory components. It is shown that stimulation of the small bowel motility is caused by serotonin activation of non-cholinergic excitatory mechanism with participation of effector cholinergic neurones. The initial suppression of the motility is caused by participation of nonadrenergic noncholinergic inhibitory mechanism, and the secondary inhibition of contractile activity of a small bowel with serotonin has an adrenergic nature.
Ovsiannikov
V I
VI
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, 197376, Acad. Pavlov St., 12, Russia.
Berezina
T P
TP
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D007583:Jejunum / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D018733:Nicotinic Antagonists / Q000494:pharmacology; D010115:Oxyphenonium / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D018490:Serotonin Agents / Q000494:pharmacology; D014851:Wakefulness
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D006584:Hexamethonium Compounds; D018727:Muscarinic Antagonists; D018733:Nicotinic Antagonists; D018490:Serotonin Agents; D012701:Serotonin; D011433:Propranolol; D010115:Oxyphenonium; C021628:benzohexonium; D010646:Phentolamine