title: Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients.
abstract: OBJECTIVE
  To (a) evaluate liver diffusion isotropy, (b) compare two diffusion-weighted magnetic resonance (MR) imaging sequences for the characterization of focal hepatic lesions by using two or four b values, and (c) determine an apparent diffusion coefficient (ADC) threshold value to differentiate benign from malignant lesions.
  
  
  METHODS
  Sixty-six patients were examined with two single-shot echo-planar diffusion-weighted MR sequences. In the first sequence, liver diffusion isotropy was evaluated by using diffusion gradients in three directions with two b values. In the second sequence, a unidirectional diffusion gradient was used with four b values. ADCs were measured in 43 patients with 52 focal hepatic lesions more than 1 cm in diameter and in 23 patients with 14 normal and nine cirrhotic livers and were compared by using nonparametric tests.
  
  
  RESULTS
  Diffusion in the liver parenchyma was isotropic. ADCs of focal hepatic lesions were significantly different between sequences (P <.01). The mean (+/- SD) ADCs in the first sequence were 0.94 x 10(-3) mm(2)/sec +/- 0.60 for metastases, 1.33 x 10(-3) mm(2)/sec +/- 0.13 for HCCs, 1.75 x 10(-3) mm(2)/sec +/- 0.46 for benign hepatocellular lesions, 2.95 x 10(-3) mm(2)/sec +/- 0.67 for hemangiomas, and 3.63 x 10(-3) mm(2)/sec +/- 0.56 for cysts. There was a significant difference between benign (2.45 x 10(-3) mm(2)/sec +/- 0.96, isotropic value) and malignant (1.08 x 10(-3) mm(2)/sec +/- 0.50) lesions (P <.01 for both sequences).
  
  
  CONCLUSIONS
  Diffusion-weighted MR imaging can help differentiate benign from malignant hepatic lesions. The use of two b values in one direction could be sufficient for the design of MR sequences in the liver.
authors.affiliation: Department of Radiology, Hôpital Beaujon and Laboratoire d'Imagerie Médicale Paris-Nord, Faculté de Médecine Paris VII, Clichy, France. bachir.taouli@radiology.ucsf.edu
authors.forename: Bachir
authors.initials: B
authors.lastname: Taouli
authors.forename: Valérie
authors.initials: V
authors.lastname: Vilgrain
authors.forename: Erik
authors.initials: E
authors.lastname: Dumont
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Daire
authors.forename: Bo
authors.initials: B
authors.lastname: Fan
authors.forename: Yves
authors.initials: Y
authors.lastname: Menu
mesh_terms: D000328:Adult; D000368:Aged; D004058:Diffusion; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies