title: A study of cardiovascular effects of Azadirachta indica (neem) on isolated perfused heart preparations.
abstract: The effects of aqueous leaf extract of Azadirachta indica were evaluated on isolated prefused frog and rabbit heart. Dose dependent negative inotropic and chronotropic effects were observed in both the heart preparation. An increase in coronary blood flow in isolated rabbit heart was observed. The effects were not blocked by atropine and mepyramine in both the preparations. The data suggests that A. indica could be of benefit in coronary artery disease and arrhythmias.
authors.affiliation: Department of Pharmacology, Pt. B.D. Sharma PGIMS, Rohtak-124 001.
authors.forename: P
authors.initials: P
authors.lastname: Khosla
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: J
authors.initials: J
authors.lastname: Singh
mesh_terms: D000818:Animals; D031601:Azadirachta; D002319:Cardiovascular System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D011817:Rabbits; D011898:Ranidae
chemical_list: D010936:Plant Extracts