Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy.
We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum-based chemotherapy. Once a level of at least 5.0% HFR was achieved, sufficient PBPC were collected in a single harvest in 71% of the procedures. Whereas, failure to mobilize sufficient PBPC occurred in 24 of 28 leukaphereses when the percentage of circulating HFR was less than 5.0%. In conclusion, circulating HFR may aid in the efficiency of PBPC collections in platinum-based chemotherapy.
Kurata
H
H
Department of Obstetrics and Gynecology, Faculty of Medicine, Niigata University, Asahimachi-dori 1-757, Niigata 951-8510, Japan. tounin@med.niigata-u.ac.jp
Takakuwa
K
K
Tsuneki
I
I
Aoki
Y
Y
Tanaka
K
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001576:Benzophenoneidum; D003131:Combined Modality Therapy; D005260:Female; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D005470:Fluorometry; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000188:drug therapy / Q000628:therapy; D006085:Graft Survival; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007937:Leukapheresis; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011446:Prospective Studies; D017463:Receptors, Complement 3b / Q000032:analysis; D017701:Reticulocyte Count
D005456:Fluorescent Dyes; D009944:Organoplatinum Compounds; D017463:Receptors, Complement 3b; D001576:Benzophenoneidum