title: Significance of p53 and bcl-2 immunoexpression in the prognosis of laryngeal squamous cell carcinoma.
abstract: This study was undertaken to determine whether p53 or bcl-2 immunoexpression has any significance in the prognosis of laryngeal squamous cell carcinoma. Eighty-four cases of laryngeal squamous cell carcinoma at different pathological stages and locations were studied. All patients were treated surgically first, and followed up for 6-96 months (mean, 35 months). p53 and bcl-2 immunoexpression in tumour cells, evaluated by image analysis and histoscore, were found in 71.4% and 46.4% of tumours, respectively. Glottic location was correlated with significantly longer survival than tumours at other locations. Pathological stage and histological grade of tumour were also significant predictors of survival. Neither p53 nor bcl-2 immunoexpression was found to be predictive of post-operative survival. Only transglottic tumours expressed significantly high levels of bcl-2. Both methods used to evaluate p53 and bcl-2 immunoexpression correlated well with each other. This study suggests that immunoexpression of p53 and bcl-2 is not a significant prognostic predictor in laryngeal squamous cell carcinoma.
authors.affiliation: Department of Pathology, GATA Haydarpasa Training Hospital, Kadikoy, Turkey. sukruyildirim@veezy.com
authors.forename: S
authors.initials: S
authors.lastname: Yildirim
authors.forename: H
authors.initials: H
authors.lastname: Cermik
authors.forename: T
authors.initials: T
authors.lastname: Işitmangil
authors.forename: H
authors.initials: H
authors.lastname: Baloglu
authors.forename: A
authors.initials: A
authors.lastname: Gungor
authors.forename: Z
authors.initials: Z
authors.lastname: Pekkafali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53