p53: regular or super?
Increased p53 expression under the endogenous promoter protects "super p53" mice from tumorigenesis without the undesirable effects of premature aging.
Roussel
Martine F
MF
Department of Genetics and Tumor Cell Biology, Danny Thomas Research Tower, 5006C, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA. martine.roussel@stjude.org
D019588:Aging, Premature / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D016922:Cellular Senescence / Q000502:physiology*; D018628:Gene Dosage; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53