[The clinical and enzymatic changes in patients with viral hepatitis G infection].
For the purpose of making sure the clinical significance of hepatitis G virus, RT-nested PCR was applied to detect HGV RNA in 165 hepatitis patients, which included 24 acute hepatitis, 78 chronic hepatitis, 18 hepatitic cirrhosis, 4 hepatocellularcarcinom and 41 HBV and HCV carriers. The results showed that the infection of HGV existed in all kinds of hepatitis patients. Among the acute hepatitis 12.5% (3/24) was HGV RNA positive. 19 (24.4%) cases were HGV RNA positive in chronic hepatitis, among which 4 cases were simply HGV RNA positive (5.13%). The serum ALT level in 3 cases of simple acute HGV patients was between 488 +/- 65 U/L, the value of AST between 452 +/- 71 U/L, the TBiL at about 77.1 +/- 14.3 mumol/L. All these showed that only HGV infection could lead to acute hepatitis. The rising enzyme dropped to normal about a month later in acute hepatitis while HGV RNA would remain. The problem whether HGV infection is caused by simple acute and chronic hepatitis infection is under investigation.
Liao
S
S
Department of Digestion, Tian Tan Affiliated Hospital of Capital University of Medical Sciences, Beijing 100050.
Zhan
M
M
Cong
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D005260:Female; D018178:Flaviviridae Infections / Q000201:enzymology / Q000821:virology*; D029407:GB virus C / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000201:enzymology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015163:Superinfection / Q000821:virology
D012367:RNA, Viral; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase