[The general theory of pathophysiological mechanisms of neurological and psychopathological syndromes].
Besides structural and functional deficits, central nervous system (CNS) damage causes another effect in the form of novel pathological integrations consisting of CNS primarily and secondarily changed structures. At the neuronal level, the integration presents as aggregation of hyperactive uncontrollable neurons, which produces enhanced uncontrolled impulse flow and acts as a generator of pathologically enhanced excitation, network type. At the system interrelation level, the integration is represented by a new pathodynamic organization including damaged CNS regions, which constitutes a pathological system (PS). The hyperactive CNS structure plays a role of a pathological determinant promoting PS formation may determine a type of PS activity. A clinical manifestation of PS activity is a corresponding neurological or psychopathological syndrome.
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D002449:Cell Aggregation / Q000502:physiology; D002493:Central Nervous System Diseases / Q000503:physiopathology* / Q000628:therapy; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology* / Q000628:therapy; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013577:Syndrome