title: Management of skeletal metastases.
abstract: Bone is a frequent site of tumour metastasis and is the third most common site of metastatic carcinoma. With advances in the use of immunotherapy, hormonal manipulation, chemotherapy and radiation for the palliation of patients with metastatic bone disease, significant improvements in survival, wellbeing and overall quality of life have been achieved.
authors.affiliation: Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD.
authors.forename: M
authors.initials: M
authors.lastname: Radford
authors.forename: C L M H
authors.initials: CL
authors.lastname: Gibbons
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D004164:Diphosphonates / Q000627:therapeutic use; D005592:Fracture Fixation / Q000379:methods; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery; D006801:Humans; D009711:Nucleotides / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D009711:Nucleotides