[Studies on inhibition of human lung carcinogenesis in early stage by oltipraz and its effects on some gene expression and regulation].
By using human fetal lung (HFL) as experimental material, the inhibition of HFL carcinogenesis in early stage by oltipraz and its molecular mechanisms were studied. The results showed that oltipraz is effective in the inhibition of carcinogenesis prior to or at the same time with Cigarette Smoking Condensate(CSC) treatment; oltipraz can decrease GSTs activity and GST-pi protein content along with its inhibition of HFL carcinogenesis; oltipraz can decrease mp53 expression; oltipraz can prevent but can not reverse the ras gene mutation; oltipraz can induce apoptosis of GLC cell obviously in a dosage of 120 micrograms/ml. Meanwhile, it is related to high expression of c-fos and low expression of GST-pi in apoptosis; oltipraz may affect c-fos gene expression through induction of a protein factor which links with DSE.
Bai
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Cancer Institute, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021.
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D005333:Fetus; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008168:Lung / Q000473:pathology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics; D011719:Pyrazines / Q000494:pharmacology*; D013638:Tars / Q000633:toxicity; D013871:Thiones; D013876:Thiophenes
D016588:Anticarcinogenic Agents; D016760:Proto-Oncogene Proteins c-fos; D011719:Pyrazines; D013638:Tars; D013871:Thiones; D013876:Thiophenes; C024746:tobacco tar; C026209:oltipraz