Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism.
Vibrational circular dichroism (VCD) measurements and density functional theory (DFT) calculations were used to obtain the first definitive assignment of the absolute configuration for the polyphenolic binaphpthyl dialdehyde gossypol and a determination of the solution conformation in CDCl(3). VCD spectra recorded for the two resolved enantiomers are near mirror images and excellent agreement between the observed IR and VCD spectra and intensity calculations carried out at the DFT (B3LYP/6-31G*) level establish the absolute configurations of (+)-gossypol as P and (-)-gossypol as M, with two conformations in CDCl(3) solution that differ in isopropyl group orientation.
Freedman
Teresa B
TB
Department of Chemistry, 1-014 Center for Science and Technology, Syracuse University, Syracuse, NY 13244-4100, USA. tbfreedm@syr.edu
Cao
Xiaolin
X
Oliveira
Regina V
RV
Cass
Quezia B
QB
Nafie
Laurence A
LA
D002942:Circular Dichroism; D006072:Gossypol / Q000737:chemistry*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014732:Vibration
D012996:Solutions; D006072:Gossypol