A guide to drug discovery: Target selection in drug discovery.
Target selection in drug discovery--defined here as the decision to focus on finding an agent with a particular biological action that is anticipated to have therapeutic utility--is influenced by a complex balance of scientific, medical and strategic considerations. In this article, we provide an introduction to the key issues in target selection and discuss the rationale for decision making.
Knowles
Jonathan
J
F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070, Basel, Switzerland. jonathan.knowles@roches.com
Gromo
Gianni
G
D001709:Biotechnology / Q000191:economics / Q000379:methods; D004345:Drug Industry / Q000191:economics / Q000379:methods / Q000639:trends; D019981:Health Care Sector; D006801:Humans; D007880:Legislation, Drug / Q000639:trends; D010600:Pharmacology / Q000191:economics / Q000379:methods*; D011955:Receptors, Drug / Q000187:drug effects
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