title: Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis.
abstract: An advanced intermediate in the synthesis of the phytotoxins cornexistin and hydroxycornexistin has been synthesized. Sequential palladium-mediated sp(2)-sp(3) fragment coupling and ring-closing diene metathesis have been used to construct the nine-membered carbocyclic core found in the natural products. [reaction--see text]
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. j.s.clark@nottingham.ac.uk
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Clark
authors.forename: Frederic
authors.initials: F
authors.lastname: Marlin
authors.forename: Bastien
authors.initials: B
authors.lastname: Nay
authors.forename: Claire
authors.initials: C
authors.lastname: Wilson
mesh_terms: D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D005658:Fungi / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D006540:Herbicides / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D001685:Biological Factors; D005663:Furans; D006540:Herbicides; C071795:cornexistin; D010165:Palladium