Administration of bisphosphonate prevents disuse bone atrophy induced by tail suspension.
We recently demonstrated that osteopenia induced by rat tail-suspension was associated with an initial increase in bone resorption. To study the significance of the increase in early bone resorption for osteopenia, we investigated whether administration of YH529, a third-generation bisphosphonate, prevents the development of osteopenia as evidenced by increased wet weight of the femur, together with its calcium and phosphorus contents, when compared with those of tail-suspended rats treated with the vehicle alone. These results suggested that the initial increase in bone resorption plays an important role in the development of osteopenia induced by tail suspension.
Kurokouchi
K
K
Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Ito
T
T
Ohmori
S
S
Kanda
K
K
Murata
Y
Y
Yasukawa
K
K
Izumi
R
R
Inazu
M
M
Iwata
H
H
Seo
H
H
D000818:Animals; D001835:Body Weight; D018488:Bone Demineralization, Pathologic / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D002118:Calcium / Q000378:metabolism*; D004164:Diphosphonates / Q000494:pharmacology*; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D019417:Hindlimb Suspension / Q000009:adverse effects*; D006811:Humerus / Q000187:drug effects / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D018474:Weightlessness Simulation
D004164:Diphosphonates; D007093:Imidazoles; C087958:YM 529; D010758:Phosphorus; D012965:Sodium Chloride; D002118:Calcium