Predicting protein subcellular localisation from amino acid sequence information.
Predicting the subcellular localisation of proteins is an important part of the elucidation of their functions and interactions. Here, the amino acid sequence motifs that direct proteins to their proper subcellular compartment are surveyed, different methods for localisation prediction are discussed, and some benchmarks for the more commonly used predictors are presented.
Emanuelsson
Olof
O
Stockholm Bioinformatics Center, Stockholm University, Stockholm, Sweden. olof@sbc.su.se
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology / Q000502:physiology*; D021382:Protein Sorting Signals; D021381:Protein Transport / Q000502:physiology; D011506:Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D012984:Software
D021382:Protein Sorting Signals; D011506:Proteins