title: Use of voriconazole to successfully treat disseminated Trichosporon asahii infection in a patient with acute myeloid leukaemia.
abstract: Trichosporon spp. is an emerging fungal pathogen in immunocompromised hosts, and disseminated infection is often fatal in neutropenic patients. Reported here is a case of disseminated infection in a neutropenic patient with acute leukaemia. After failure of amphotericin B and fluconazole therapy, the course of infection dramatically improved with voriconazole treatment. A literature search revealed 69 additional cases of disseminated Trichosporon spp. infections in neutropenic patients, and these are also reviewed. Clinical symptoms that suggest infection include fever, disseminated papulopustular cutaneous lesions and pulmonary involvement. Despite treatment with antifungal agents (amphotericin B, fluconazole), 78% of patients died. Voriconazole may represent a promising therapy for this life-threatening infection.
authors.affiliation: Department of Infectious Diseases, Saint Louis Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France. sandra.fournier@sls.ap-hop-paris.fr
authors.forename: S
authors.initials: S
authors.lastname: Fournier
authors.forename: W
authors.initials: W
authors.lastname: Pavageau
authors.forename: M
authors.initials: M
authors.lastname: Feuillhade
authors.forename: S
authors.initials: S
authors.lastname: Deplus
authors.forename: A-M
authors.initials: AM
authors.lastname: Zagdanski
authors.forename: O
authors.initials: O
authors.lastname: Verola
authors.forename: H
authors.initials: H
authors.lastname: Dombret
authors.forename: J M
authors.initials: JM
authors.lastname: Molina
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D009503:Neutropenia / Q000150:complications; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012307:Risk Factors; D014230:Triazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014250:Trichosporon / Q000187:drug effects / Q000502:physiology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole