Results of vitrectomy and the no-touch-technique using autologous adjuvants in macular hole treatment.
BACKGROUND
Anatomic and functional results of macular holes using vitrectomy and platelet-concentrate (PC) or autologous whole blood (WB) were investigated without peeling any epiretinal membrane in order to minimize retinal trauma.


METHODS
44 patients with macular holes stage II, III and IV underwent a vitrectomy with removal of posterior cortical vitreous (in stage II and III) and C2F6 gas endotamponade. No peeling of any epiretinal membrane or the ILM was performed. In 14 patients autologous WB was injected and in 30 patients autologous PC. The mean follow-up time was 9.3 months.


RESULTS
An anatomic closure was observed in 36.4% of patients in the WB-group and in 93.9% of patients in the PC-group. SLO-microperimetry showed a reduction of absolute scotomas in 80% of the WB- and in 75% of the PC-group. In the WB-group 1 retinal detachment and 1 branch vein occlusion occurred; in the PC-group 3 retinal detachments, 1 central artery occlusion, 1 macular pucker, 1 cystoid macular edema, 1 late reopening and 1 secondary glaucoma were observed. In both groups no endophthalmitis occurred.


CONCLUSIONS
If autologous platelet concentrate is available, high anatomic success rates can be achieved without aggressive membrane removal, which may cause retinal damage. Autologous whole blood cannot be recommended as an alternative adjunct for the treatment of macular holes without membrane removal.
Hoerauf
H
H
Eye-Hospital, University of Lübeck, Germany. hhoerauf@ophtha.mu-luebeck.de
Klüter
H
H
Joachimmeyer
E
E
Roider
J
J
Framme
C
C
Schlenke
P
P
Kirchner
H
H
Lagua
H
H
D000328:Adult; D000368:Aged; D001769:Blood; D001792:Blood Platelets; D005260:Female; D005466:Fluorocarbons / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000628:therapy*; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*
D005466:Fluorocarbons; C042852:perflutren