[Effect of L-dicentrine on contraction of rat stomach muscle strips].
OBJECTIVE
To study the effect of L-dicentrine on the contraction of rat stomach muscle strips induced by 5-HT, histamine K+ and Ca2+.


METHODS
In-vitro experimenting on rat stomach muscle strips.


RESULTS
The contraction of the strips induced by 5-HT histamine K+ and Ca2+ after high K+ depolarization was markedly inhibited by L-dicentrine or papaverine, showing a non-competitive antagonism. The contraction induced by 5-HT was inhibited by L-dicentrine in Ca2+ free solution. L-Dicentrine inhibited the contraction induced by 5-HT, depending on Ca2+ released from the intracellular store. When the Ca2+ concentration in both solutions was restored, L-dicentrine did not influence the contraction significantly.


CONCLUSIONS
L-Dicentrine could relax the rat stomach smooth muscle. In rat stomach smooth muscles there exist 5-HT receptors.
Li
H L
HL
Department of Pharmacology, Kunming Medical College, Kunming 650031, Yunnan, China.
Zhang
R P
RP
Ye
H T
HT
Wang
H
H
D000818:Animals; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D029583:Menispermaceae / Q000737:chemistry; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects
D001060:Aporphines; C067342:dicentrine