[Antibacterial activity of new-quinolone and macrolide antibiotics against oral bacteria].
Minimum Inhibitory Concentration (MIC) of 4 new-quinolone antibacterial reagents and 4 macrolide antibiotics against periodontopathic bacteria 21 species 24 strains of standard strains including oral related bacteria and clinical isolated (1993-1999) 20 strains of Porphyromonas gingivalis, 7 strains of Actinobacillus actinomycetemcomitans were determined. Minocycline HCl was used as the comparative reagent. Macrolide showed moderate antibacterial activity against standard strains of oral related bacteria except Fusobacterium nucleatum. New-quinolone showed excellent activity against Eikenella corrodens and Actinobacillus actinomycetemcomitans. Concerning to the clinical isolated strains, Clarithromycin effected P. gingivalis (MIC90 0.1 microgram/ml) and Levofloxacin and Ciprofloxacin showed high-potency antibacterial activity against clinical isolated Actinobacillus actinomycetemcomitans (MIC90 0.013-0.025 microgram/ml).
Eguchi
Toru
T
Department of Environmental Health, Azabu University.
Shimizu
Yasumitsu
Y
Furuhata
Katsunori
K
Fukuyama
Masafumi
M
D042462:4-Quinolones; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D018942:Macrolides; D009055:Mouth / Q000382:microbiology*; D010518:Periodontitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides