title: Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus).
abstract: The emetic responses induced by staphylococcal enterotoxin A (SEA), SEB, SEC2, SED, SEE, SEG, SEH, and SEI in the house musk shrew (Suncus murinus) were investigated. SEA, SEE, and SEI showed higher emetic activity in the house musk shrew than the other SEs. SEB, SEC2, SED, SEG, and SEH also induced emetic responses in this animal model but relatively high doses were required. The house musk shrew appears to be a valuable model for studying the mechanisms of emetic reactions caused by SEs.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550, Japan.
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Hu
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Omoe
authors.forename: Yu
authors.initials: Y
authors.lastname: Shimoda
authors.forename: Akio
authors.initials: A
authors.lastname: Nakane
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Shinagawa
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004639:Emetics / Q000008:administration & dosage; D004768:Enterotoxins / Q000008:administration & dosage / Q000235:genetics; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D012788:Shrews; D013203:Staphylococcal Infections / Q000139:chemically induced; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D018089:Superantigens / Q000008:administration & dosage / Q000235:genetics; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D004639:Emetics; D004768:Enterotoxins; D018089:Superantigens