[Correlation and significance of E-cadherin and N-cadherin expression in prostate cancer].
OBJECTIVE
Decreased expression of E-Cadherin correlated with many kinds of cancer, but inappropriate expression of N-cadherin has been reported in breast cancer recently, which has a more distinct and direct role in promoting cancer cell motility than E-cadherin. The aim of this study was to investigate the correlation between E-Cadherin and N-Cadherin expression with the grade and stage of prostate cancer and their relationship with prostate specific antigen (PSA).


METHODS
E-Cadherin and N-Cadherin expression in 56 prostate cancer samples were determined by immunohistochemical staining.


RESULTS
Twenty-four patients (43%) were positive and 32 patients (57%) were negative in E-Cadherin expression. Eighteen patients (32%) were negative and 38 patients (68%) were positive in N-Cadherin expression. E-Cadherin and N-Cadherin were significantly related to the grade and stage of cancer and the change of F/T ratio (free prostate specific antigen/total prostate specific antigen ratio). There was no significant relationship between Cadherin expression and total prostate specific antigen (tPSA) or free prostate specific antigen (fPSA).


CONCLUSIONS
E-Cadherin and N-Cadherin abnormal expressions may serve as the indicators to malignant degree and prognosis of the prostate cancer.
Huang
Xiao
X
Department of Urology, First Affiliated Hospital, Pebing University, Beijing 100034, P. R. China.
Zhou
Li-qun
LQ
Ai
Jun-kui
JK
Lu
Ying-qian
YQ
Bai
Yin
Y
Zeng
Li
L
Zhang
Zhi-wen
ZW
Guo
Ying-lu
YL
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D015820:Cadherins; D017430:Prostate-Specific Antigen