title: Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.
abstract: This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
authors.affiliation: Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA. lgcosta@u.washington.edu
authors.forename: Lucio G
authors.initials: LG
authors.lastname: Costa
authors.forename: Toby B
authors.initials: TB
authors.lastname: Cole
authors.forename: Gail P
authors.initials: GP
authors.lastname: Jarvik
authors.forename: Clement E
authors.initials: CE
authors.lastname: Furlong
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase; D016893:Carotid Stenosis / Q000235:genetics; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003324:Coronary Artery Disease / Q000235:genetics; D004950:Esterases / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D007306:Insecticides / Q000378:metabolism* / Q000633:toxicity; D015810:Linkage Disequilibrium; D009943:Organophosphorus Compounds; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human