Combinatorial glycosylation of glycopeptide antibiotics.
The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin.
Baltz
Richard H
RH
Natural Products Research, Cubist Pharmaceuticals, Lexington, MA 02421, USA.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D005964:Glucosyltransferases / Q000378:metabolism; D006031:Glycosylation; D017334:Teicoplanin / Q000031:analogs & derivatives; D014640:Vancomycin / Q000031:analogs & derivatives
D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin; D005964:Glucosyltransferases