title: Diffuse axonal injury: detection of changes in anisotropy of water diffusion by diffusion-weighted imaging.
abstract: Myelinated axons of white matter demonstrate prominent directional differences in water diffusion. We performed diffusion-weighted imaging on ten patients with head injury to explore the feasibility of using water diffusion anisotropy for quantitating diffuse axonal injury. We showed significant decrease in diffusion anisotropy indices in areas with or without signal abnormality on T2 and T2*-weighted images. We conclude that the water diffusion anisotropy index a potentially useful, sensitive and quantitative way of diagnosing and assessing patients with diffuse axonal injury.
authors.affiliation: Department of Diagnostic Radiology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, N.T., Hong Kong, China. jchm888@yahoo.com
authors.forename: J H M
authors.initials: JH
authors.lastname: Chan
authors.forename: E Y K
authors.initials: EY
authors.lastname: Tsui
authors.forename: W C G
authors.initials: WC
authors.lastname: Peh
authors.forename: D
authors.initials: D
authors.lastname: Fong
authors.forename: K F
authors.initials: KF
authors.lastname: Fok
authors.forename: K M
authors.initials: KM
authors.lastname: Leung
authors.forename: M K
authors.initials: MK
authors.lastname: Yuen
authors.forename: K K L
authors.initials: KK
authors.lastname: Fung
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D020833:Diffuse Axonal Injury / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D014867:Water
chemical_list: D014867:Water