title: Inflammation markers in relation to cognition in a healthy aging population.
abstract: The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baseline correlated negatively with cognitive performance on the Stroop and Word Learning Recall test over the 6 years follow-up period. C-reactive protein (CRP) levels at baseline correlated negatively with performance on the Word Learning tests over the 6 years follow-up period. Thus, relatively high concentrations of haptoglobin and C-reactive protein may be indicative for impaired cognitive performance.
authors.affiliation: Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience (Euron), Universiteit Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands. c.teunissen.cell@med.vu.nl
authors.forename: C E
authors.initials: CE
authors.lastname: Teunissen
authors.forename: M P J
authors.initials: MP
authors.lastname: van Boxtel
authors.forename: H
authors.initials: H
authors.lastname: Bosma
authors.forename: E
authors.initials: E
authors.lastname: Bosmans
authors.forename: J
authors.initials: J
authors.lastname: Delanghe
authors.forename: C
authors.initials: C
authors.lastname: De Bruijn
authors.forename: A
authors.initials: A
authors.lastname: Wauters
authors.forename: M
authors.initials: M
authors.lastname: Maes
authors.forename: J
authors.initials: J
authors.lastname: Jolles
authors.forename: H W M
authors.initials: HW
authors.lastname: Steinbusch
authors.forename: J
authors.initials: J
authors.lastname: de Vente
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism; D003072:Cognition Disorders / Q000097:blood / Q000276:immunology* / Q000523:psychology; D004522:Educational Status; D004660:Encephalitis / Q000097:blood / Q000276:immunology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006242:Haptoglobins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D006242:Haptoglobins; D018836:Inflammation Mediators; D002097:C-Reactive Protein