title: Endocytosis and vesicle trafficking.
abstract: Several common themes have emerged from recent structural and functional studies of proteins involved in the formation of coated vesicles. For example, inositol polyphosphate lipid headgroups are bound specifically by a variety of different domains in ways appropriate to domain function. Another theme is the recognition of short sequence motifs in structureless regions of other coat components, allowing dynamic multicomponent networks to be established.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. pre@mrc-lmb.cam.ac.uk
authors.forename: Philip R
authors.initials: PR
authors.lastname: Evans
authors.forename: David J
authors.initials: DJ
authors.lastname: Owen
mesh_terms: D001665:Binding Sites; D001692:Biological Transport; D002966:Clathrin / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D050356:Lipid Metabolism; D008958:Models, Molecular; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D002966:Clathrin