[Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats].
Comparative effects of the partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of liver cell plasma membranes were investigated in cats under conditions of hemorrhagic shock. Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol. The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipid composition of liver cell plasma membranes by increasing the content of phosphatidylserine and by decreasing the contents of sphingomyelin and lysophosphatidylcholine. The protective effect of butorphanol on liver cells was more pronounced than that of buprenorphine.
Leskova
G F
GF
Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, 125315 Russia, Moscow, Baltiyskaya str., 8.
Arkhipenko
Iu V
IuV
D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D002077:Butorphanol / Q000494:pharmacology*; D002415:Cats; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011957:Receptors, Opioid / Q000819:agonists*; D012771:Shock, Hemorrhagic / Q000378:metabolism*
D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010743:Phospholipids; D011957:Receptors, Opioid; D002047:Buprenorphine; D002077:Butorphanol