Inflating cell numbers by Wnt.
One of the prominent biological phenomena controlled by Wnt signaling is the expansion of cells with predefined fates. In the November 27, 2002, issue of Cell, Rosenfeld and colleagues describe an example of Wnt-controlled proliferation during genesis of the cardiac outflow tract and the pituitary gland. As a downstream target gene of the Wnt cascade, the bicoid-related transcription factor Pitx2 directly drives proliferation in these tissues.
Clevers
Hans
H
Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.
D000818:Animals; D002455:Cell Division; D006321:Heart / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism; D008934:Mitogens / Q000502:physiology; D009206:Myocardium / Q000166:cytology; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000097577:Homeobox Protein PITX2
D018398:Homeodomain Proteins; D008934:Mitogens; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000097577:Homeobox Protein PITX2