[Expression of mucin MUC1 and MUC2 in colorectal carcinoma and their clinical significance].
OBJECTIVE
The up-regulation of mucin MUC1 expression or down-regulation of mucin MUC2 expression may be involved in carcinogenesis of some neoplasms, but there was few report about the relationship between mucin MUC1 and MUC2 expression and Chinese colorectal carcinoma. The aim of this study was to explore relationship between expression of mucin MUC1 and MUC2 in colorectal carcinoma and clinicopathological parameters and their clinical significance.


METHODS
The expression of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were detected by S-P immunohistochemical technique.


RESULTS
The positive expression rates of mucin MUC1 and MUC2 in normal colorectal mucosa were 0 and 100%, respectively, but the positive expression rates of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were 42.1% and 36.5%, respectively (P < 0.01); the expression of mucin MUC1 was positive correlated to the depth of invasion, lymph node metastasis, and Dukes staging (P < 0.05), but negative correlated to the degree of differentiation (P < 0.05); mucin MUC2 expression was related to invasion, lymph node metastasis, and Dukes staging (P < 0.05), but unrelated to differentiation (P > 0.05).


CONCLUSIONS
The up-regulation of mucin MUC1 expression or down-regulation of mucin MUC2 expression may be involved in carcinogenesis and progression in colorectal carcinoma, and the detecting of mucin MUC1 and MUC2 may be predicting its prognosis in colorectal carcinoma.
Huang
Wen-bin
WB
Department of Pathology, Wannan Medical College, Wuhu 241001, P. R. China. huangwb@mail.ahwhptt.net.cn
Shi
Liang-hui
LH
Zhu
Xiao-qun
XQ
Xu
Guo-xiang
GX
Qi
Qiong
Q
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D055262:Mucin-2; D009077:Mucins / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; C524625:MUC2 protein, human; D018396:Mucin-1; D055262:Mucin-2; D009077:Mucins