[Cell cycle analysis and pathological changes of malignant tumors treated with electrochemical therapy].
To investigate the mechanism and to observe the effectiveness of electrochemical therapy(ECT), 33 patients of late stage cancers which treated by ECT were included in this study. Flow cytometry (FCM) and pathology were used to observe the changes of tumor cells before and after ECT. Tumor cells of G1, G2/M, S phases and aneuploid cells were found to be killed almostly and the ratio of apoptosis was elevated greatly after ECT. Also, pathological evidence proved the death of tumor cells and some characters of apoptosis. So, ECT can non-selectively kill tumor cells and induce the apoptosis of them, and FCM was a way to evaluate the effectiveness of ECT.
Liu
J
J
Center of Oncology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Wei
Y
Y
Luo
F
F
Lu
S
S
Peng
Y
Y
Lei
S
S
Zhao
X
X
Yan
Y
Y
D000328:Adult; D000368:Aged; D017209:Apoptosis; D002453:Cell Cycle; D004599:Electric Stimulation Therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*