Atypical presentations of thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) usually presents in a fulminant fashion with marked hematologic abnormalities often associated with fever and neurologic and renal abnormalities. Two cases of TTP are reported in which neurologic deficits were initially the dominant findings, followed weeks later by the pronounced hematologic manifestations. Young patients with unexplained neurologic findings, even if there is only minimal anemia or thrombocytopenia, should be monitored for subsequent manifestations of TTP so that treatment may be instituted promptly.
O'Brien
Timothy E
TE
Division of Hematology/Oncology, Department of Medicine, MetroHealth Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA. tobrien@metrohealth.org
Crum
Edward D
ED
D000328:Adult; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D018908:Muscle Weakness / Q000209:etiology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis* / Q000188:drug therapy; D013064:Speech Disorders / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome