title: [Effect of eradication of Helicobacter pylori infection on endoscopic findings and symptoms of gastroesophageal reflux].
abstract: Gastroesophageal reflux disease (GORD) represents an illness which reflects a syndrome caused by returning of acid gastric, alkaline pancreatic and bowels content into the oesophagus, which is in the stomach, because of the protective mechanisms of oesophageal loss. The aim of this study was that this prospective study should explain the role of Helicobacter pylori infection in modification of GORD, respectively whether the Helicobacter pylori infection acts protectively or by deterioration of the disease. According to the settled rules, the inquiry was performed as well as the selection of 97 candidates to undergo research in this study. Helicobacter pylori infection has been proved by immunoassay in all pts in the beginning of this study. Endoscopy has been performed in all pts, the degree of gastroesophageal reflux disease by Sawary-Miller was done. The main group consisted of 50 candidates in whom the eradication of Helicobacter pylori infection was done with triple therapy, pantoprazol + amoxycilin + klaritromicin, which was proven by an immunoassay test. Two groups of pts were formed: the main one with eradicated Helicobacter infection, and a controlled one with a Helicobacter positive infection, which was subject to modification of life style. During 12 months, this study consisted of endoscopic evaluations and monthly evaluation of pts daily difficulties. The eradication of Helicobacter pylori infection acts on the improvement of gastroesophageal disease course by improvement of endoscopic findings by Sawary-Miller, and by decreasing daily acid symptoms. The eradication of Helicobacter pylori infection in gastroesophageal reflux disease does it act at the symptoms such as heartburn, weekly acid symptoms and chest pain.
authors.affiliation: Klinika za Gastroentrohepatologiju, Klinicki centar Sarajevo.
authors.forename: Rusmir
authors.initials: R
authors.lastname: Mesihović
authors.forename: Boris
authors.initials: B
authors.lastname: Vucelić
authors.forename: Ismet
authors.initials: I
authors.lastname: Bratović
authors.forename: Mehmed
authors.initials: M
authors.lastname: Gribajcević
authors.forename: Ivan
authors.initials: I
authors.lastname: Selak
mesh_terms: D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D011446:Prospective Studies