title: Lethal factor to mice produced by Escherichia coli isolated from chickens with swollen head syndrome.
abstract: A lethal toxin similar to Bacillus cererus lethal toxin was detected in the culture supernatants of Escherichia coli isolated from chickens with swollen head syndrome. The lethal activity was heat-labile, protease-sensitive and killed mice within 10 min. The light microscopy of the histopathological studies revealed that the principal organ affected by this toxin was the lung but the liver and kidneys also showed lesions. The relevance of this lethal activity from E. coli remains to be determined.
authors.affiliation: Departamento de Microbiologia e Imunologia, Instituto to de Biologia, Universidade Estadual de Campinas, Campinas, SP Brazil, cep 13081-970.
authors.forename: Marcia Regina
authors.initials: MR
authors.lastname: Salvadori
authors.forename: Ana Marisa
authors.initials: AM
authors.lastname: Chudzinski-Tavassi
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Baccaro
authors.forename: Claudete Serrano Astolfi
authors.initials: CS
authors.lastname: Ferreira
authors.forename: Antonio José Piantino
authors.initials: AJ
authors.lastname: Ferreira
authors.forename: Júlia
authors.initials: J
authors.lastname: Prado-Franceschi
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Yano
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000633:toxicity*; D002645:Chickens; D004768:Enterotoxins / Q000096:biosynthesis / Q000633:toxicity*; D004926:Escherichia coli / Q000302:isolation & purification / Q000378:metabolism*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000401:mortality* / Q000473:pathology / Q000662:veterinary; D005260:Female; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011201:Poultry Diseases / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; D004768:Enterotoxins; C040792:enterotoxin, Bacillus cereus