title: Preoperative assessment of hepatic function: Utility of a new convenient two-compartment model analysis using galactosyl human serum albumin scintigraphy.
abstract: OBJECTIVE
  Preoperative hepatic function was evaluated using technetium-99 m-diethylenetriaminepenta-acetic acid-galactosyl-human serum albumin (Tc-GSA) and a scintillation camera to detect hepatic Tc-GSA uptake by the asialoglycoprotein receptor.
  
  
  METHODS
  Sixty-two preoperative patients with liver cancer, including hepatocellular and cholangiocellular carcinomas, were studied, using two-parameter two-compartment model analysis. This model is simpler than either the three- or five-compartment model, both of which are accurate but which require complicated analysis and enormous calculation. The parameters k1 and k2 represented the transfer rate constant from the blood to the liver and from the liver to the blood, respectively. We calculated k1, k2, and k1/k2 from time-radioactivity curves of the heart and liver as well as VLmg, which represented the maximal amount of Tc-GSA in the liver.
  
  
  RESULTS
  The results were compared to those of conventional liver function analysis using Tc-GSA (the index of blood clearance (HH15) and the receptor index (LHL15)) or indocyanine green (ICGR15). Both HH15 and LHL15 were significantly correlated with k1, k1/k2, and VLmg. In addition, they closely correlated with the results of ICGR15 and some serum hepatic function tests (aspartate aminotransferase, choline esterase, albumin, platelet). The pathological grading for liver cirrhosis also correlated with k1, k1/k2, and VLmg. From a clinical point of view, VLmg had a significant correlation with the Child-Pugh score.
  
  
  CONCLUSIONS
  These results suggest that this new compartment analysis will be useful in evaluating liver function, as it is accurate, simple and convenient.
authors.affiliation: Department of Surgery, Osaka Red Cross Hospital, Osaka, Japan. koichikinoshita@yahoo.co.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Minoru
authors.initials: M
authors.lastname: Ukikusa
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwaisako
authors.forename: Akira
authors.initials: A
authors.lastname: Arimoto
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fujisawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Hironori
authors.initials: H
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Seo
authors.forename: Masato
authors.initials: M
authors.lastname: Naitoh
authors.forename: Akinari
authors.initials: A
authors.lastname: Nomura
authors.forename: Takuya
authors.initials: T
authors.lastname: Inomoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitai
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higashiyama
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D007208:Indocyanine Green; D016284:Technetium Tc 99m Pentetate