Evaluation of hepatoprotective activity of Ginkgo biloba in rats.
The mechanism of hepatoprotective effects of Ginkgo biloba (GB), an herbal preparation with wide variety of therapeutic application, on paracetamol (Pcml) induced hepatic damage in rats has been investigated. GB treatment restored the marker enzyme levels indicating the in vivo protective effects against Pcml induced liver damage both in preventive and curative aspects. GB also reversed the increased TBARS levels, and elevated the GSH content of the liver. The results obtained from the study indicate hepatoprotective nature of GB, which might be due to its ability to prevent lipid peroxidation and replenishing the gllutathione level. The effects of GB were comparable to that of silymarin.
Shenoy
K Ashok
KA
Department of Pharmacology, Kasturba Medical College, Mangalore-575 001.
Somayaji
S N
SN
Bairy
K L
KL
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020441:Ginkgo biloba; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts