Efficacy of azithromycin, praziquantel and mirazid in treatment of cryptosporidiosis in school children.
The study was conducted at a primary school in Abis 8 village. 88 children aged eleven years consented to participate in the present study. After fecal examination, 43 (48.8%) cases were found infected with Cryptosporidium. The mean oocysts number per high power field (HPF) ranged from (1.6-48 oocysts/HPF). Azitbromycin, praziquantel (PZQ) and mirazid were given to 13, 16 and 14 infected children respectively. Three weeks after treatment, azithromycin and praziquantel gave cure rates of 91% and 56.2% respectively with a percent reduction of oocysts in stools of 99% for azithromycin and 71.5% for PZQ. Mirazid was not effective. All the three drugs were well tolerated. It was concluded that azithromycin is highly effective in the treatment of children with cryptosporidiosis: PZQ decreases the infection rate and intensity.
Allam
Amal F
AF
Department of Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Shehab
Amel Y
AY
D000818:Animals; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D029744:Commiphora; D003457:Cryptosporidiosis / Q000188:drug therapy*; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D009865:Oocytes; D010270:Parasite Egg Count; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*; D012574:Schools; D016896:Treatment Outcome
D003049:Coccidiostats; D028321:Plant Preparations; D011223:Praziquantel; D017963:Azithromycin