Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses.
Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.
Kohmoto
Mariko
M
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Ikeda
Yasuhiro
Y
Sato
Eiji
E
Nishimura
Yorihiro
Y
Inoshima
Yasuo
Y
Shimojima
Masayuki
M
Tohya
Yukinobu
Y
Mikami
Takeshi
T
Miyazawa
Takayuki
T
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002415:Cats; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D016181:Feline Acquired Immunodeficiency Syndrome / Q000635:transmission* / Q000821:virology; D005260:Female; D016089:Immunodeficiency Virus, Feline / Q000235:genetics* / Q000276:immunology; D016180:Lentivirus Infections / Q000635:transmission / Q000821:virology; D008969:Molecular Sequence Data; D009092:Mucous Membrane / Q000821:virology*; D009154:Mutation; D018523:Tropism; D014621:Vagina / Q000821:virology
D000914:Antibodies, Viral