title: Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's Law.
abstract: Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.
authors.affiliation: The Johns Hopkins University School of Medicine, 451 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA. sk@jhmi.edu
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kern
mesh_terms: D020022:Genetic Predisposition to Disease; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000266:history*; D009857:Oncogenes; D012175:Retinoblastoma / Q000235:genetics