NF-kappaB activation by protein kinase C isoforms and B-cell function.
B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor-kappaB (NF-kappaB) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF-kappaB activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB.
Moscat
Jorge
J
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid, Canto Blanco, Spain. jmoscat@cbm.uam.es
Diaz-Meco
María T
MT
Rennert
Paul
P
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D051550:I-kappa B Kinase; D007527:Isoenzymes / Q000502:physiology; D046911:Macromolecular Substances; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D016328:NF-kappa B / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D021122:Protein Subunits; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic
D007527:Isoenzymes; D046911:Macromolecular Substances; D016328:NF-kappa B; D021122:Protein Subunits; D011947:Receptors, Antigen, B-Cell; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; C496564:Chuk protein, mouse; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human; C496562:Ikbkb protein, mouse; C496566:Ikbke protein, mouse; D011493:Protein Kinase C