A putative link between exocytosis and tumor development.
Desmoplastic small round cell tumor (DSRCT) is characterized by a t(11;22)(p13;q12) translocation breakpoint. In this issue of Cancer Cell, now show that the resulting EWS-WT1 gene-fusion product leads to overexpression of BAIAP3, a protein implicated in regulated exocytosis.
Chan
Andrew M
AM
Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA. andrew.chan@mssm.edu
Weber
Thomas
T
D020533:Angiogenesis Inhibitors; D000818:Animals; D018288:Carcinoma, Small Cell / Q000235:genetics*; D005089:Exocytosis / Q000235:genetics* / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D011506:Proteins / Q000235:genetics; D034802:RNA-Binding Protein EWS / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D020533:Angiogenesis Inhibitors; D011506:Proteins; D034802:RNA-Binding Protein EWS