Effect of panangin on activity of messengers systems in hypertrophied rat myocardium.
The balance between the two major second messenger systems in hypertrophied myocardium was studied in rats receiving panangin for 16 days. Panangin producing stimulating and polarizing effects on cardiomyocyte membrane improved electrophysiological characteristics of hypertrophied myocardium (electrical stability, duration of supernormal excitability period, and action potential), activated the phosphoinositide exchange, and inhibited the adenylate cyclase system. The panangin-induced change in membrane potentials was accompanied by a pronounced inositol response, i.e. a decrease in the content of membrane polyphosphoinositides (phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-biphosphate) in the brain. It was concluded that function of ion channels depends on activity of phosphoinositide- and adenylate cyclase second messengers systems.
Vishnevskii
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AA
Institute of High-Altitude Physiology and Experimental Pathology, Kirgizian National Academy of Sciences, Bishkek.
Berlyakov
A A
AA
D000818:Animals; D001011:Aorta / Q000473:pathology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006984:Hypertrophy; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007477:Ions / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011195:Potassium Magnesium Aspartate / Q000494:pharmacology*; D051381:Rats; D015398:Signal Transduction; D013997:Time Factors
D002316:Cardiotonic Agents; D007477:Ions; D011195:Potassium Magnesium Aspartate; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP