title: Total synthesis of gambierol.
abstract: The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of alpha-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.
authors.affiliation: Research Center for Sustainable Materials Engineering, Institute of Multidisciplinary Research for Advanced Materials, and Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kadota
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Takamura
authors.forename: Kumi
authors.initials: K
authors.lastname: Sato
authors.forename: Akio
authors.initials: A
authors.lastname: Ohno
authors.forename: Kumiko
authors.initials: K
authors.lastname: Matsuda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D002922:Ciguatoxins; D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D008387:Marine Toxins / Q000138:chemical synthesis*; D009498:Neurotoxins / Q000138:chemical synthesis; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D035964:Oxocins
chemical_list: D002922:Ciguatoxins; D004988:Ethers, Cyclic; D008387:Marine Toxins; D009498:Neurotoxins; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins