title: Ring-opening metathesis phase-trafficking (ROMpt) synthesis: multistep synthesis on soluble ROM supports.
abstract: The use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers that are isolated via precipitation with methanol. Once formed, the ROM oligomers serve as soluble supports for further solution-phase reactions, including a ring-closing metathesis. After each step, the support-bound products are isolated by precipitation with a suitable solvent. [reaction--see text]
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Harned
authors.forename: Shubhasish
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Flynn
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D011232:Chemical Precipitation; D002625:Chemistry, Organic / Q000379:methods*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry
chemical_list: D011108:Polymers; D012997:Solvents