[GABApentin--new therapeutic possibilities].
The paper is a review of current experience with use of gabapentin--a new antiepileptic drug--in neurologic conditions others than epilepsy. Mechanism of action of the drug is not fully elucidated yet. However it proved to be effective in therapy of chronic pain, especially in neuropathic pain, neuralgia, low back pain, reflex sympathetic dystrophy and erythromelalgia. Gabapentin is also effective in pain and spasticity in multiple sclerosis. Clinical studies of gabapentin in movement disorders, such as Parkinson disease, essential tremor and atrophic lateral sclerosis are discussed in the paper. It can be summarized that gabapentin is a valuable medication and the use thereof in neurology is not limited to epilepsy.
Jagustyn
Piotr
P
Kliniki Neurologii Wojskowego Instytutu Medycyny Lotniczej.
Romaniak
Agnieszka
A
D000085:Acetates / Q000627:therapeutic use*; D000588:Amines; D000700:Analgesics / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids; D004916:Erythromelalgia / Q000188:drug therapy; D000077206:Gabapentin; D006801:Humans; D017116:Low Back Pain / Q000188:drug therapy; D009069:Movement Disorders / Q000188:drug therapy; D009103:Multiple Sclerosis / Q000188:drug therapy; D009128:Muscle Spasticity / Q000188:drug therapy; D009437:Neuralgia / Q000188:drug therapy; D012019:Reflex Sympathetic Dystrophy / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D018692:Antimanic Agents; D000978:Antiparkinson Agents; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin