[Study on sensitivity of neuroglioma to chemotherapeutic drugs].
In this study, the chemosensitivity of 36 cases' fresh neuroglioma specimens was examined in vitro with MTT assay. The separation method for single tumor cell, the number of planting of cells, and the dosage and acting time of drugs, which have effects on the results of MTT assay, were studied systematically. On the basis of this experiment, we established a screening method for the chemosensitivity of neuroglioma; it is accurate, rapid, and simple. At the same time, the results showed that neuroglioma was more sensitive to the chemotherapeutic drugs Vm26, DDP and MMC, and the sensitivity varied with not only the drugs but also the individuals.
Jiang
S
S
Department of Neurosurgery, First Affiliatted Hospital, WCUMS, Chengdu 610041.
Yuan
S
S
Wang
Y
Y
Chen
X
X
Song
Y
Y
Yang
Y
Y
Mao
B
B
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005910:Glioma / Q000473:pathology*; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents