title: Import of nuclear-encoded proteins into mitochondria.
abstract: The majority of mitochondrial proteins are encoded by nuclear genes, synthesized in the cytosol and subsequently imported into mitochondria through protein translocation machineries of the outer and inner membranes. In this review, we discuss the arrangement of the various translocation complexes and the function of individual import components. We also outline the various targeting pathways that preproteins can take in order to reach their appropriate sub-mitochondrial compartment.
authors.affiliation: Department of Biochemistry, La Trobe University 3086, Melbourne, Australia.
authors.forename: Diana
authors.initials: D
authors.lastname: Stojanovski
authors.forename: Amelia J
authors.initials: AJ
authors.lastname: Johnston
authors.forename: Illo
authors.initials: I
authors.lastname: Streimann
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Hoogenraad
authors.forename: Michael T
authors.initials: MT
authors.lastname: Ryan
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000502:physiology; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D014176:Protein Biosynthesis / Q000502:physiology*; D011498:Protein Precursors / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
chemical_list: D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; D011498:Protein Precursors; D018160:Receptors, Cytoplasmic and Nuclear; D029701:Saccharomyces cerevisiae Proteins; C102549:TIM22 protein, S cerevisiae