title: Cytotoxic ergosterols from Paecilomyces sp. J300.
abstract: Seven ergosterol derivatives (1-7) were isolated from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as 3beta,5alpha-dihydroxy-ergosta-7,22-diene (1), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14), 22-diene-3beta, 7alpha-diol (2), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3beta,7alpha-diol (3), ergosta-4,6,8(14),22-tetraene-3-one (4), ergosterol (5), ergosterol endoperoxide (6), 3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene (7). Compounds 3-7 showed moderate cytotoxicity against five tumor cells.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.forename: Sang Deuk
authors.initials: SD
authors.lastname: Zee
authors.forename: Sae Yun
authors.initials: SY
authors.lastname: Cho
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D012831:Bombyx; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D010143:Paecilomyces / Q000737:chemistry* / Q000302:isolation & purification; D014407:Tumor Cells, Cultured
chemical_list: D004875:Ergosterol