title: Ob/ob mice as a model of delayed gastric emptying.
abstract: Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice (P<.01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication.
authors.affiliation: Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Asakawa
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
authors.forename: Naohiko
authors.initials: N
authors.lastname: Ueno
authors.forename: Susumu
authors.initials: S
authors.lastname: Makino
authors.forename: Masaharu
authors.initials: M
authors.lastname: Uemoto
authors.forename: Masayuki A
authors.initials: MA
authors.lastname: Fujino
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
mesh_terms: D000375:Aging; D000818:Animals; D048909:Diabetes Complications; D004195:Disease Models, Animal; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005746:Gastric Emptying; D018589:Gastroparesis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity
chemical_list: C090116:Idremcinal; D004917:Erythromycin