Pars, PI 3-kinase, and the establishment of neuronal polarity.
As reported in this issue of Cell, the protein complex consisting of mPar3, mPar6, and atypical protein kinase C is selectively localized to the axonal growth cone of cultured hippocampal neurons and is required for specification of the axon.
Banker
Gary
G
Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97201, USA.
D000818:Animals; D001369:Axons / Q000502:physiology; D016764:Cell Polarity / Q000235:genetics; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D016501:Neurites / Q000737:chemistry / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051381:Rats; D018179:Receptors, Thrombin / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D018179:Receptors, Thrombin; C105295:protease-activated receptor 3; D019869:Phosphatidylinositol 3-Kinases