The molecular and genetic basis of colon cancer.
Remarkable progress has been accomplished in understanding the molecular basis of genetic colon cancer syndromes including FAP and HNPCC, and their variants; of sporadic colon cancer; and of the rare hamartomatous polyp syndromes. This molecular progress now has to be translated into clinical progress in molecular diagnosis, and in pharmacologic therapy for colonic polyps and cancers. It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer.
Robbins
David H
DH
Dr. Henry D. Janowitz Division of Gastroenterology, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
Itzkowitz
Steven H
SH
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D003113:Colonoscopy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D017491:Genes, APC / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D018895:Microsatellite Repeats / Q000502:physiology; D009154:Mutation