title: Optimization of operating conditions in a high-shear mixer using dem model: determination of optimal fill level.
abstract: For the purpose of evaluating optimal fill level of starting materials in a high-shear mixer, discrete element method (DEM) simulation was conducted to visualize kinetic status between particles. The simulation results obtained by changing fill levels were used to determine solid fraction of particles, particle velocity, particle velocity vector, and kinetic energy and discuss the flow pattern. Optimal fill level was obtained from the information on these matters. It was pointed out that understanding the kinetic energy between particles in an agitating vessel was effective in determining the optimal fill level. Granulation experiment was conducted to validate the optimal fill level obtained by the simulation, confirming the good agreement between these two results. It was pointed out that determination of kinetic energy between particles through the simulation was effective in obtaining an index of the kinetic status of particles. Further, it was confirmed that the simulation could provide more information than conventional granulation experiments could provide and also helpful in optimizing the operating conditions.
authors.affiliation: Department of Engineering, Osaka Prefecture University, Sakai, Osaka, Japan. terasita@chemeng.osakafu-u.ac.jp
authors.forename: Keijiro
authors.initials: K
authors.lastname: Terashita
authors.forename: Takehiko
authors.initials: T
authors.lastname: Nishimura
authors.forename: Susumu
authors.initials: S
authors.lastname: Natsuyama
mesh_terms: D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods; D004345:Drug Industry / Q000295:instrumentation* / Q000379:methods; D007700:Kinetics; D008962:Models, Theoretical; D010316:Particle Size; D011208:Powders; D012399:Rotation; D013607:Tablets
chemical_list: D011208:Powders; D013607:Tablets