A closer look of the HECTic ubiquitin ligases.
In comparison with previous studies, a new crystal structure of a HECT ubiquitin ligase catalytic domain has revealed the structural basis of the conformational flexibility of the enzyme and provides insights into the mechanism underlying the ubiquitin transfer reaction in the polyubiquitination pathway.
Zheng
Ning
N
D001665:Binding Sites; D020134:Catalytic Domain; D011487:Protein Conformation; D025801:Ubiquitin / Q000737:chemistry* / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry* / Q000378:metabolism
D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases