Inhibitory activity of corn-derived bisamide compounds against alpha-glucosidase.
Bioassay guided fractionation from corn gluten meal, a byproduct of a starch manufacturing plant, gave N-p-coumaroyl-N'-feruloylputrescine (1) and N,N'-diferuloylputrescine (2) as alpha-glucosidase inhibitors. Some structure-activity relationships were studied by comparing the inhibitory activity by preparing some related compounds, and it was revealed that the hydroxyl group was important for the inhibitory activity of bisamide alkaloids, but not the redox potential.
Niwa
Toshio
T
Department of Research and Development, San-ei Sucrochemical Company, Ltd., Chita 478-8503, Japan. toshio-niwa@sanei-toka.co.jp
Doi
Umeyuki
U
Osawa
Toshihiko
T
D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D011700:Putrescine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014462:Ultrafiltration; D003313:Zea mays / Q000737:chemistry*
D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C065165:feruloylputrescine; C004999:ferulic acid; D011700:Putrescine