[Effect of GABA and pyracetam on mitochondrial ADP phosphorylation in experimental hypokinesia].
Long-term limitation of motor activity of male rats is accompanied by impairments of mitochondrial ADP phosphorylation in liver and heart. The most significant changes were observed after 15 and 45 days of hypokinesia. Administration of GABA and pyracetam to animals subjected to hypokinesia induced a tendency to "normalization" of ADP phosphorilation processes.
Sotskiĭ
O P
OP
Department of Pharmacology, Yerevan State Medical University Koryun, st. 2.
Akopian
V P
VP
Zhamgarian
L G
LG
Zhamgarian
A G
AG
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000818:Animals; D018476:Hypokinesia / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D018697:Nootropic Agents / Q000494:pharmacology*; D010766:Phosphorylation; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018697:Nootropic Agents; D005680:gamma-Aminobutyric Acid; D000244:Adenosine Diphosphate; D013385:Succinate Dehydrogenase; D010889:Piracetam