Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics.
Recruitment of inflammatory leukocytes to the injured spinal cord is a physiological response that is associated with the production of cytokines and proteinases that are involved in host defense and wound repair. Cells in the spinal cord are mainly post-mitotic and tissue regeneration is poor; thus, these inflammatory mediators can exacerbate the damage to spared tissue and thereby impair spontaneous functional recovery. Although several aspects of immune function might benefit the CNS, experimental studies indicate that acute neuroinflammation aggravates tissue injury. Until the timing and nature of the molecular signals that govern leukocyte recruitment and activation after spinal injury are defined, clinical therapies designed to boost immune cell function should be avoided.
Popovich
Phillip G
PG
Department of Molecular Virology, Immunology and Medical Genetics, 2078 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA. Popovich.2@osu.edu
Jones
T Bucky
TB
D000818:Animals; D006801:Humans; D007107:Immune System / Q000473:pathology*; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D015213:Neuroimmunomodulation; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000473:pathology*