title: Reactivity against Sarcocystis neurona and Neospora by serum antibodies in healthy French horses from two farms with previous equine protozoal myeloencephalitis-like cases.
abstract: Sarcocystis neurona is considered a leading cause of equine protozoal myeloencephalitis (EPM), a common infectious neurological disease in horses in the Americas. EPM-like cases associated with S. neurona peptide reactive antibodies in Western blots were recently described in Normandy, France. In this report, antibodies reacting with S. neurona merozoites were detected using an agglutination assay at titers ranging from 50 to 500 in sera from 18/50 healthy horses from two farms with a previous EPM-like case. Higher values were found in older animals. Four out of six horses which traveled or stayed in the US exhibited titers over 50, a higher figure than in the group which did not travel out of France or stayed in an other European country. No correlation was found between anti-S. neurona and anti-Neospora sp. antibody titers. Data prompt further study of significance of anti-S. neurona antibodies in clinically healthy or diseased European horses, and identification of putative immunizing parasite(s) and their host(s).
authors.affiliation: Laboratoire Départemental Frank Duncombe, 1 route de Rosel, Caen, France.
authors.forename: P H
authors.initials: PH
authors.lastname: Pitel
authors.forename: D S
authors.initials: DS
authors.lastname: Lindsay
authors.forename: S
authors.initials: S
authors.lastname: Caure
authors.forename: S
authors.initials: S
authors.lastname: Romand
authors.forename: S
authors.initials: S
authors.lastname: Pronost
authors.forename: G
authors.initials: G
authors.lastname: Gargala
authors.forename: S M
authors.initials: SM
authors.lastname: Mitchell
authors.forename: C
authors.initials: C
authors.lastname: Hary
authors.forename: P
authors.initials: P
authors.lastname: Thulliez
authors.forename: G
authors.initials: G
authors.lastname: Fortier
authors.forename: J J
authors.initials: JJ
authors.lastname: Ballet
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology; D003048:Coccidiosis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary; D004679:Encephalomyelitis / Q000276:immunology / Q000469:parasitology* / Q000662:veterinary*; D005260:Female; D005602:France; D006734:Horse Diseases / Q000276:immunology / Q000469:parasitology*; D006736:Horses / Q000276:immunology / Q000469:parasitology*; D008297:Male; D018688:Neospora / Q000276:immunology*; D012522:Sarcocystis / Q000276:immunology*; D012523:Sarcocystosis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary; D014195:Travel
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan