title: Mutagenesis strategies for identifying novel loci associated with disease phenotypes.
abstract: The systematic identification of the function of all the genes in the mammalian genome is one of the major scientific challenges for the 21st century. A comprehensive insight into mammalian gene function will illuminate our understanding of the genetic bases of disease. Mouse mutagenesis is a powerful tool for the study of mammalian gene function. Most recently, a number of approaches employing the chemical mutagen ethylnitrosourea (ENU) have been utilised by mouse geneticists to deliver a substantial new collection of mouse disease models. The growing mouse mutant archive provides a powerful resource for the identification of novel genes involved with human genetic disease.
authors.affiliation: MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Oxon OX11 0RD, UK. s.brown@har.mrc.ac.uk
authors.forename: Steve D M
authors.initials: SD
authors.lastname: Brown
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Hardisty
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D023281:Genomics; D051379:Mice; D016296:Mutagenesis; D010641:Phenotype
chemical_list: D005038:Ethylnitrosourea