Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.
Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.
Saratikov
A S
AS
Department of Pharmacology, Siberian State Medical University, Tomsk. albert@post.tomica.ru
Novozheeva
T P
TP
Akhmedzhanov
R R
RR
D015058:1-Naphthylisothiocyanate / Q000494:pharmacology*; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology*
D001463:Barbiturates; D001559:Benzhydryl Compounds; C476801:halodif; C062695:halonal; D015058:1-Naphthylisothiocyanate; D014508:Urea; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase; C016914:flumecinol; D001663:Bilirubin; C002915:benzobarbital; D010634:Phenobarbital