Chlorambucil and acute intermittent porphyria.
A 54-year-old women with quiescent acute intermittent porphyria (AIP) developed low-grade non-Hodgkin's lymphoma. She was successfully treated with chlorambucil without any significant rise in urinary proto-porphyrins. The case is described and a review of chemotherapy use in AIP is presented.
Davies
J H
JH
St Lukes Cancer Center, Royal Surrey County Hospital, Guildford, UK.
Whitaker
S J
SJ
D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008875:Middle Aged; D017118:Porphyria, Acute Intermittent / Q000139:chemically induced*
D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil