[The significance of postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage in burn patients].
OBJECTIVE
To observe the postburn changes in the plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage.


METHODS
Nineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control.


RESULTS
The plasma levels of ICAM-1, IL-10 and TNFalpha increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P < 0.05 - 0.01).


CONCLUSIONS
The monitoring of the postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha might be helpful in the forecast of postburn sepsis and the development of MODS.
Kuang
Xinjian
X
Department of Burns, The Second Affiliated Hospital of Kunming Medical College, Kunming 650000 Yunnan Province, P.R. China.
Ma
Kexian
K
Duan
Tiwu
T
D000328:Adult; D002056:Burns / Q000276:immunology*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000276:immunology; D018805:Sepsis / Q000276:immunology; D012769:Shock / Q000276:immunology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10