Glomerular changes in hereditary single-gene diseases.
Molecular genetics has strongly influenced clinical medicine and particularly nephrology. Several gene mutations of single-gene hereditary nephropathies have been recently identified. These data are useful to develop methods of diagnosis and treatment, but also to understand the pathogenesis of these particular disorders. In this review we focused on several monogenic hereditary renal diseases inducing nephrotic syndrome and other hereditary diseases with renal involvement and progression towards end-stage renal failure.
Sessa
Adalberto
A
Department of Nephrology and Dialysis, Vimercate Hospital, Milan, Italy. adsess@tin.it
Meroni
Mietta
M
Battini
Graziana
G
Maglio
Alessia
A
Righetti
Marco
M
Fabris
Elisabetta
E
Nebuloni
Manuela
M
Pallotti
Francesco
F
Giordano
Ferdinando
F
Tosoni
Antonella
A
D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology* / Q000503:physiopathology*