Association of hypoadiponectinemia with coronary artery disease in men.
BACKGROUND
Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD).


RESULTS
The consecutive 225 male patients were enrolled from inpatients who underwent coronary angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma adiponectin levels in the CAD patients were significantly lower than those in the control subjects. Multiple logistic regression analysis including plasma adiponectin level, diabetes mellitus, dyslipidemia, hypertension, smoking habits, and body mass index revealed that hypoadiponectinemia was significantly and independently correlated with CAD (P<0.0088). The entire study population was categorized in quartiles based on the distribution of plasma adiponectin levels. The interquartile cutoff points were 4.0, 5.5, and 7.0 microg/mL. The multivariate-adjusted odds ratios for CAD in the first, second, and third quartiles were 2.051 (95% confidence interval [CI], 1.288 to 4.951), 1.221 (95% CI, 0.684 to 2.186), and 0.749 (95%CI, 0.392 to 1.418), respectively.


CONCLUSIONS
Male patients with hypoadiponectinemia (<4.0 microg/mL) had a significant 2-fold increase in CAD prevalence, independent of well-known CAD risk factors.
Kumada
Masahiro
M
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan.
Kihara
Shinji
S
Sumitsuji
Satoru
S
Kawamoto
Toshiharu
T
Matsumoto
Satoru
S
Ouchi
Noriyuki
N
Arita
Yukio
Y
Okamoto
Yoshihisa
Y
Shimomura
Iichiro
I
Hiraoka
Hisatoyo
H
Nakamura
Tadashi
T
Funahashi
Tohru
T
Matsuzawa
Yuji
Y
D052242:Adiponectin; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011506:Proteins / Q000378:metabolism*; D012307:Risk Factors
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins