Hypoglycemic activity of ginseng glycopeptide.
OBJECTIVE
To study the hypoglycemic activity of ginseng glycopeptide (GGP).


METHODS
Normal mice or rabbits and alloxan or streptozotocin-induced hyperglycemic rats or mice were used in the study. Blood glucose and liver glycogen levels of the experimental animals during the trial period were analyzed by spectrophotometry with O-toluidine and iodine reagents, respectively.


RESULTS
Significant decreases in blood glucose and liver glycogen levels were induced in a dose-dependent manner after administration of GGP 50, 100, or 200 mg/kg injected ip or sc to normal mice and injected im 30 or 60 mg/kg to normal rabbits. The hypoglycemic activity of GGP lasted for about 16 h, and were examined in both normal animals and hyperglycemic animals.


CONCLUSIONS
GGP injection induced the pronounced decreases in blood glucose and liver glycogen levels in both normal and hyperglycemic animals.
Wang
Ben-Xiang
BX
Jilin Institute of Natural Medicine, Jilin University, Changchun 130021, China. cctcmwbx@public.cc.jl.cn
Zhou
Qiu-Li
QL
Yang
Ming
M
Wang
Yan
Y
Cui
Zhi-Yong
ZY
Liu
Yong-Qiang
YQ
Ikejima
Takashi
T
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006020:Glycopeptides / Q000302:isolation & purification / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D006020:Glycopeptides; D007004:Hypoglycemic Agents; D013311:Streptozocin; D000496:Alloxan; D006003:Glycogen