Oxygen transport and myocardial function after the administration of albumin 5%, hydroxyethylstarch 6% and succinylated gelatine 4% to rabbits.
OBJECTIVE
The effects of administering albumin 5%, hydroxyethylstarch 6% and succinylated gelatine 4% on oxygen transport and left ventricular function were prospectively investigated in different experimental conditions: baseline, fluid load, after 10 min of myocardial ischaemia and after reperfusion.


METHODS
Twenty-seven rabbits received at random one of three colloids in escalating boluses over 10-15 min to achieve left ventricular end-diastolic pressures (LVEDP) between 8 and 10mmHg. A branch of the left anterior descending coronary artery was then temporarily occluded by a ligature and released after 10 min. Myocardial function was assessed using left ventricular pressure recordings and dimension data obtained from ultrasound crystals inserted onto the ventricular wall. Blood was sampled for the determination of oxygen delivery and consumption, the oxygen extraction ratio, acid-base status, and glucose and lactate concentrations.


RESULTS
Administration of the colloids similarly increased oxygen delivery and improved left ventricular function in all groups. Peak rate of pressure development (dP/dt(max)) and oxygen delivery were reduced during ischaemia and reperfusion. The decrease in dP/dt(max) was more pronounced in the hydroxyethylstarch group.


CONCLUSIONS
Administration of albumin 5%, hydroxyethylstarch 6% and succinylated gelatine 4% had similar effects on oxygen delivery and myocardial function. After ischaemia and during reperfusion, the decrease in myocardial function was most pronounced with hydroxyethylstarch 6%.
Himpe
D G
DG
Middelheim General Hospital, Department of Anaesthesia and Intensive Care, Antwerp, Belgium. dirk.himpe@planetinternet.be
De Hert
S G
SG
Vermeyen
K M
KM
Adriaensen
H F
HF
D000418:Albumins / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001784:Blood Gas Analysis; D005780:Gelatin / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D010101:Oxygen Consumption / Q000187:drug effects*; D010952:Plasma Substitutes / Q000494:pharmacology*; D011446:Prospective Studies; D011817:Rabbits; D013213:Starch / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D000418:Albumins; D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin; D013213:Starch