title: Prognostic significance of tumor volume after radical prostatectomy: a multivariate analysis of pathological prognostic factors.
abstract: OBJECTIVE
  To analyze the association between Gleason score, stage and status of surgical margins with tumor volume in prostate cancer progression after radical prostatectomy.
  
  
  METHODS
  200 consecutive radical prostatectomy specimens were analyzed. Preoperative clinical stage, PSA, results of prostate biopsies as well as pathological results were noted. A biochemical recurrence was defined as a single, postoperative detectable PSA level (>0.2 ng/ml). Tumor volume was compared to postoperative staging, Gleason score, and surgical margin status to predict tumor progression. Univariate and multivariate analysis using stepwise logistic regression were used to identify parameters with additional prognostic value.
  
  
  RESULTS
  Pathological results of the prostatectomy specimens showed 149 (74.5%) pT2a-b, 29 (14.5%) pT3a and 22 (11%) pT3b tumors. Tumor volume was 0.57 cc for pT2a, 1.2cc for pT2b, 1.7cc for pT3a and 2.9cc for pT3b, respectively (p<0.05). Taken together, mean volume for pT2 and pT3 were 1.06 and 2.2 cc, respectively (p<0.0001). Five-year progression-free actuarial survival was 69.7%. Using univariate analysis, tumor progression correlated with final Gleason score (p<0.0007), positive surgical margins (p=0.02), tumor volume (p=0.009) and stage (p<0.0001). In a multivariate analysis, tumor progression correlated only with the final Gleason score (p=0.04) and stage (p=0.0002).
  
  
  CONCLUSIONS
  Gleason score and pathological stage are independent factors to predict prostate cancer progression after radical prostatectomy. When these parameters are known, tumor volume does not provide additional information.
authors.affiliation: Department of Urology, Henri Mondor Hospital, Créteil, France. laurent.salomon@hmn.ap-hop-paris.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Salomon
authors.forename: Olivier
authors.initials: O
authors.lastname: Levrel
authors.forename: Aristotelis G
authors.initials: AG
authors.lastname: Anastasiadis
authors.forename: Jacques
authors.initials: J
authors.lastname: Irani
authors.forename: Alexandre
authors.initials: A
authors.lastname: De La Taille
authors.forename: Fabien
authors.initials: F
authors.lastname: Saint
authors.forename: Dimitri
authors.initials: D
authors.lastname: Vordos
authors.forename: Antony
authors.initials: A
authors.lastname: Cicco
authors.forename: Andras
authors.initials: A
authors.lastname: Hoznek
authors.forename: Dominique
authors.initials: D
authors.lastname: Chopin
authors.forename: Claude Clément
authors.initials: CC
authors.lastname: Abbou
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*