[Domoic acid and glutamate receptors].
Domoic acid is a kind of neurotoxin produced by diatoms and accumulated in food chain, which is harmful to the human health. The N-methyl-D-aspartate receptor and kainic acid/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor could be activated by domoic acid. The concentration of the intracellular Ca2+ could be elevated, causing a series of physiological and biochemical changes. The possible mechanisms of neurotoxicity induced by domoic acid through glutamate receptors are discussed.
Chen
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Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021, China.
Wang
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C
D000818:Animals; D006801:Humans; D007608:Kainic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives*; D009498:Neurotoxins / Q000009:adverse effects*; D018091:Receptors, AMPA / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
D007608:Kainic Acid; D009498:Neurotoxins; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; C012301:domoic acid