title: [Studies on preparation of herba epimedii total flavonoids phytosomes and their pharmaceutics].
abstract: OBJECTIVE
  To optimize preparation techniques for Herba Epimedii flavonoid phytosomes (EFP) and explore their suitable pharmaceutics.
  
  
  METHODS
  To optimize the preparation conditions by means of uniform design and step regression, prepare Herba Epimedii total flavonoid phytosomes by means of solvent evaporation and investigate the accumulative dissolution of different ratios of EFP-PVP precipitates by means of dissolution release.
  
  
  RESULTS
  The optimized preparation conditions are as follows: solvent-tetrahydrofuran, lecithin to PVP--2.5 times, temperature--40 degrees C and reaction--3 hours. Oil/water apparent partition coefficient of icariin was enhanced more than 4 times by phospholipid. The accumulative dissolution of Herba Epimedii flavonoids of EFP-PVP precipitate was significantly higher than that of its physical mixture and Herba Epimedii extract tablet.
  
  
  CONCLUSIONS
  Phospholipid can effectively enhance the oil/water apparent partition coefficient of icariin, and PVP can improve the dissolution of Herba Epimedii phytocomes, but the pharmacokinetics needs further study.
authors.affiliation: Guangzhou Railway Central Hospital, Guangzhou 510080, Guangdong, China.
authors.forename: Y N
authors.initials: YN
authors.lastname: Jiang
authors.forename: Z P
authors.initials: ZP
authors.lastname: Yu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yang
authors.forename: J M
authors.initials: JM
authors.lastname: Chen
mesh_terms: D002214:Capsules; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D034181:Epimedium / Q000737:chemistry; D010743:Phospholipids; D010946:Plants, Medicinal / Q000737:chemistry; D011205:Povidone; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D010743:Phospholipids; C046314:epimedii flavone; D011205:Povidone