Direct cadherin-activated cell signaling: a view from the plasma membrane.
Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane.
Yap
Alpha S
AS
School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072. a.yap@mailbox.uq.edu.au
Kovacs
Eva M
EM
D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D015820:Cadherins; D020741:rho GTP-Binding Proteins