title: Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy.
abstract: A steepest-descent gradient algorithm is developed to optimize the stepping of a 90Sr/90Y radiation source train (RST) for intravascular brachytherapy (IVB). The objective function is to deliver a uniform dose in a coronary target vessel and minimize the dose in adjacent normal vessel tissue at the proximal and distal edges of the coronary target vessel. Based on the target length and number of dwell points (number of steps), the algorithm modulates the dwell times and corresponding dwell positions that optimize the weighted addition of staggered EGS4 Monte Carlo (MC) calculated dose distribution from a single RST. Stepping treatment plans are generated for target vessel lengths of 3.0, 3.3, and 3.8 cm. For both the unoptimized and optimized plans, the dose heterogeneity in the target vessel wall, and length of nontarget vessel receiving 3 Gy, is assessed to compare plans. Optimization results show a 14% dose uniformity within the target is achievable for all vessel lengths. Further, the dose in the adjacent normal tissue is lower in the optimized plans than the unoptimized plans. The work presented in this paper provides a model to address the finite length of RST in IVB treatments. While the results presented are specific to the 90Sr/90Y RST, the methods should apply to other finite length RSTs.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Cente, Durham, North Carolina 27710, USA. miften@radonc.duke.edu
authors.forename: Moyed M
authors.initials: MM
authors.lastname: Miften
authors.forename: Shiva K
authors.initials: SK
authors.lastname: Das
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Shafman
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D001918:Brachytherapy / Q000379:methods*; D002318:Cardiovascular Diseases / Q000532:radiotherapy*; D003198:Computer Simulation; D006801:Humans; D009010:Monte Carlo Method; D011868:Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D013326:Strontium Radioisotopes / Q000627:therapeutic use*; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D011868:Radioisotopes; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes