title: A general and expeditious one-pot synthesis of sulfoxides in high optical purity from norephedrine-derived sulfamidites.
abstract: A general and simple procedure for preparing any kind of enantiomerically enriched sulfoxide starting from norephedrine-derived N-benzyloxycarbonylsulfamidite 3a is reported. After one-pot reaction of 3a with RMgX, HBF(4), and R'MgX, a variety of sulfoxides 6 are obtained in ee usually higher than 93% and isolated yields ranging between 50 and 78%. The obtained configuration is tunable by simply electing the order of the addition of the reagents. [reaction--see text]
authors.affiliation: Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. joseluis.garcia.ruano@uam.es
authors.forename: José L
authors.initials: JL
authors.lastname: García Ruano
authors.forename: Carlos
authors.initials: C
authors.lastname: Alemparte
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Aranda
authors.forename: María M
authors.initials: MM
authors.lastname: Zarzuelo