[The relationship between expression of oncogene proteins and HBeAg in chronic hepatitis B virus infection].
To study the relationship between abnormal expression of oncogene protein and HBV replication, we detected the expression of protein products C-erbB-2 P185, ras P21 and tumorsuppressor gene product P53 and HBeAg in the serum of 64 patients with chronic HBV infection by using immunohistochemical technique and ELISA. The results were as follows. The positive detection rates of serum HBeAg in C-erbB-2 P185 and ras P21 oncogenes positive groups were 89.4% and 84.6% respectively, but only 20% and 48% in C-erbB-2 P185 and ras P21 negative groups. It suggested that there is a close correlation between the over-expression of C-erbB-2 P185, ras P21 and replication of HBV.
Hong
F
F
Jining First People's Hospital, Shandong Province 272111.
Zhang
C
C
Zhao
H
H
D000293:Adolescent; D000328:Adult; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000254:growth & development; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015689:Oncogene Protein p21(ras) / Q000096:biosynthesis* / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication
D006513:Hepatitis B e Antigens; D015689:Oncogene Protein p21(ras); D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53