title: Cardiac troponin I is increased after interventional closure of atrial septal defects.
abstract: This study was designed to assess possible myocardial injury caused by interventional closure of atrial septal defects (ASDs) compared to diagnostic catheterization by measuring cardiac troponin I (cTn-I). Forty patients were enrolled; in 33 ASDs were successfully closed, while in 7 a diagnostic balloon sizing of the defect was performed only. Total cTn-I increased significantly from 0.1 to 1.9 microg/l at the end of the intervention and 2.23 at 4 hr and decreased to 1.35 at 15 hr. No significant increase could be detected in patients with diagnostic balloon sizing only or of CK/CK-MB levels either. Following interventional closure of ASDs with Amplatzer septum/PFO occluders, increased cTn-I levels for several hours indicate some transient, reversible myocardial membrane instability due to the device. Discrimination of ventricular myocardial infarction might be possible by estimating less sensitive CK and CK-MB levels only.
authors.affiliation: Department for Congenital Heart Defects and Pediatrics Cardiology, German Heart Center Berlin, Berlin, Germany. chrpees@yahoo.com
authors.forename: Christiane
authors.initials: C
authors.lastname: Pees
authors.forename: Nikolaus A
authors.initials: NA
authors.lastname: Haas
authors.forename: Joachim
authors.initials: J
authors.lastname: von der Beek
authors.forename: Peter
authors.initials: P
authors.lastname: Ewert
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
authors.forename: Peter E
authors.initials: PE
authors.lastname: Lange
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D021721:Balloon Occlusion / Q000009:adverse effects*; D006328:Cardiac Catheterization / Q000009:adverse effects*; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006335:Heart Injuries / Q000097:blood* / Q000209:etiology*; D006344:Heart Septal Defects, Atrial / Q000097:blood* / Q000628:therapy*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form