title: Peptide and antibody imaging in lung cancer.
abstract: Noninvasive differentiation of malignant from benign pulmonary nodules and the staging of lung cancer are major challenges and opportunities for radionuclide imaging. Despite the performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in addressing these needs, access to PET imaging in the United States and other countries is still limited for many people. Furthermore, FDG-PET imaging has left room for improvement. Thus, the need for addressing these diagnostic issues exists for a significant portion of the population of the United States and the rest of the world. Labeled antibody and peptide single-photon emission computed tomography imaging offers a reasonable alternative for these indications and comes close to FDG-PET imaging in performance, along with a lower cost when all overhead is included. Although these tracers have a high sensitivity in the diagnosis of primary and metastatic tumors, their specificity is limited by uptake in granulomatous disease, similar to that of FDG-PET. Regardless of these daunting challenges, radiolabeled antibody and peptide imaging deserves a recognized role in the clinical management of lung cancer.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Mount Sinai Hospital, New York, NY, USA.
authors.forename: Josef
authors.initials: J
authors.lastname: Machac
authors.forename: Borys
authors.initials: B
authors.lastname: Krynyckyi
authors.forename: Chun
authors.initials: C
authors.lastname: Kim
mesh_terms: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007205:Indium Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D010455:Peptides; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals; D013004:Somatostatin / Q000031:analogs & derivatives; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007205:Indium Radioisotopes; D015609:Organotechnetium Compounds; D010455:Peptides; D019275:Radiopharmaceuticals; C094279:indium-111-octreotide; D013004:Somatostatin; C109626:technetium Tc 99m-nofetumomab merpentan; D015282:Octreotide