title: Cutting edge: L-selectin (CD62L) expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigen.
abstract: Naive CD4+ T cells use L-selectin (CD62L) expression to facilitate immune surveillance. However, the reasons for its expression on a subset of memory CD4+ T cells are unknown. We show that memory CD4+ T cells expressing CD62L were smaller, proliferated well in response to tetanus toxoid, had longer telomeres, and expressed genes and proteins consistent with immune surveillance function. Conversely, memory CD4+ T cells lacking CD62L expression were larger, proliferated poorly in response to tetanus toxoid, had shorter telomeres, and expressed genes and proteins consistent with effector function. These findings suggest that CD62L expression facilitates immune surveillance by programming CD4+ T cell blood and lymph node recirculation, irrespective of naive or memory CD4+ T cell phenotype.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Georgetown University School of Medicine, Washington, DC 20053, USA. rhengel@nih.gov
authors.forename: Richard L
authors.initials: RL
authors.lastname: Hengel
authors.forename: Vishakha
authors.initials: V
authors.lastname: Thaker
authors.forename: Mark V
authors.initials: MV
authors.lastname: Pavlick
authors.forename: Julia A
authors.initials: JA
authors.lastname: Metcalf
authors.forename: Glynn
authors.initials: G
authors.lastname: Dennis
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lempicki
authors.forename: Irini
authors.initials: I
authors.lastname: Sereti
authors.forename: H Clifford
authors.initials: HC
authors.lastname: Lane
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D002455:Cell Division / Q000276:immunology; D002469:Cell Separation; D048429:Cell Size / Q000276:immunology; D002478:Cells, Cultured; D015536:Down-Regulation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D007399:Interphase / Q000276:immunology*; D019041:L-Selectin / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000276:immunology*; D015183:Restriction Mapping; D016615:Telomere / Q000737:chemistry / Q000235:genetics; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D013745:Tetanus Toxoid; D019041:L-Selectin