Women's angiographic vitamin and estrogen trial: design and methods.
The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more angiographically documented coronary stenoses of 15-75% at baseline were assigned in a 2 x 2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years.
Hsia
Judith
J
Department of Medicine, George Washington University, Washington, DC, USA. jhsia@mfa.gwu.edu
Alderman
Edwin L
EL
Verter
Joel I
JI
Rogers
William J
WJ
Thompson
Paul
P
Howard
Barbara V
BV
Cobb
Frederick R
FR
Ouyang
Pamela
P
Tardif
Jean Claude
JC
Higginson
Lyall
L
Bittner
Vera
V
Barofsky
Ivan
I
Steffes
Michael
M
Gordon
David J
DJ
Proschan
Michael
M
Younes
Naji
N
Waters
David
D
D000975:Antioxidants / Q000627:therapeutic use*; D002170:Canada; D017023:Coronary Angiography; D003327:Coronary Disease / Q000517:prevention & control*; D023381:Endpoint Determination; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D012107:Research Design; D014481:United States
D000975:Antioxidants