Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice.
The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.
Fattorini
Lanfranco
L
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità STA, Rome, Italy.
Tan
Dejiang
D
Iona
Elisabetta
E
Mattei
Maurizio
M
Giannoni
Federico
F
Brunori
Lara
L
Recchia
Simona
S
Orefici
Graziella
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001372:Aza Compounds; D004359:Drug Therapy, Combination; D005000:Ethionamide / Q000008:administration & dosage / Q000627:therapeutic use*; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011804:Quinolines; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D005000:Ethionamide; D000077266:Moxifloxacin