title: Antibiotic bone cement for the treatment of Pseudomonas aeruginosa in joint arthroplasty: comparison of tobramycin and gentamicin-loaded cements.
abstract: One hundred clinical isolates of Pseudomonas aeruginosa were collected from 22 medical centers throughout Europe and were challenged with two aminoglycoside-loaded bone cements, employing a modified in vitro Kirby-Bauer susceptibility model. The results of this study show that Simplex P with tobramycin exhibits antibacterial activity against 98% of the strains tested, compared to 93% for Palacos with gentamicin. Additionally, for strains that were susceptible to the antibiotic bone cement formulations, the average zone of inhibition produced around the tobramycin-loaded cement disks was approximately 25% greater than that seen around the gentamicin-loaded cement disks. This difference was statistically significant (p << 0.01). Tobramycin-loaded bone cement is therefore the preferred formulation when addressing Pseudomonas aeruginosa in septic joint arthroplasty.
authors.affiliation: Department of Materials Research, Advanced Technology Group, Howmedica Osteonics, Mahwah, NJ 07430, USA. cscott@howost.com
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Scott
authors.forename: Paul A
authors.initials: PA
authors.lastname: Higham
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D007595:Joint Prosthesis; D008826:Microbial Sensitivity Tests; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins; D014031:Tobramycin