[Bone lesions in elderly multiple myeloma].
We investigated the incidence of bone lesions in elderly cases of multiple myeloma (MM) and the course of those lesions, and also evaluated the relationships of skeletal symptoms with prognostic factors, and prognosis. The subjects were 146 patients, aged 65 years or more (median age 74, range 65-97 year), who were admitted to 11 institutions between January, 1988 and December, 1997. They consisted of 64 men and 82 women. The disease type was IgG type in 88 patients, IgA type in 37 patients, Bence-Jones (BJ) type in 17 patients, IgD type in three patients, and non-secretory type in one patient. Bone lesions in elderly MM patients were compared with those in 65 non-elderly MM patients. Skeletal symptoms were noted in 104 patients, and bone pain in 75 patients at the time of diagnosis. The bone lesions were evaluated as only osteolytic lesions in 26 patients, osteolytic lesions + osteoporosis in 23 patients, only osteoporosis in 2 patients and pathologic bone fractures in 53 patients. The occurrence rate of osteoporosis plus osteolytic lesion was higher in elderly patients (63.5%) than that in non-elderly patients (NE-MM group) (28.3%) (p < 0.0001). The bone lesions were most often observed in lumbar vertebrae (58.7%), cranial bone (56.7%), thoracic vertebrae (40.4%) and ribs (27.9%). The occurrence rate of bone lesion in lumbar vertebrae was higher in elderly patients (58.7%) than that in non-elderly patients (22.6%) (p < 0.0001). The life activities were limited in 71 patients because of the bone lesions. The relationship between the prognostic factors of MM and bone lesions was evaluated. There was a significant difference in the serum Ca level between patients with and without bone pain (P < 0.0001) and between those with and without pathologic bone fracture (P < 0.01). There was a significant difference in the appearance rate of plasma cells in the bone marrow between the patients with and without bone lesions (P < 0.05), between those with and without bone pain (P < 0.01), and between those with and without pathologic fracture (P < 0.05). There was a significant difference in the serum beta 2-microglobulin level between the patients with and without bone pain, and between those with and without pathologic fracture. There were no significant differences in survival times between elderly MM patients with and without bone lesions, bone pain and pathological bone fractures, while significant differences of survival times were found between non-elderly MM patients with and without bone lesions, bone pain and pathological bone fractures (P < 0.05, each). These data suggest that there are some differences in bone lesions between elderly and non-elderly MM patients.
Umeda
Masanori
M
First Department of Internal Medicine, Toho University School of Medicine.
Adachi
Yamao
Y
Tomiyama
Junji
J
Takasaki
Masaru
M
Shin
Koichi
K
Mori
Mayumi
M
Tsutsumi
Hisashi
H
Murai
Yoshirou
Y
Mutoh
Yoshitomo
Y
Tomoyasu
Shigeru
S
Kawato
Masafumi
M
Nakamura
Noriko
N
Metori
Shouhei
S
Yamaguchi
Hisomu
H
D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000401:mortality / Q000473:pathology*; D010014:Osteolysis; D010024:Osteoporosis / Q000209:etiology; D010146:Pain / Q000209:etiology; D011379:Prognosis; D015996:Survival Rate