Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.
Gunderson
Brent W
BW
Department of Experimental and Clinical Pharmacology, The University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, USA.
Ibrahim
Khalid H
KH
Peloquin
Charles A
CA
Hovde
Laurie B
LB
Rotschafer
John C
JC
D000081:Acetamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D015308:Anaerobic Threshold / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects*; D006207:Half-Life; D000069349:Linezolid; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid