title: Does soft tissue cancer affect the development of radionuclide-induced skeletal malignancy?
abstract: Data in the archives of the beagle project at the University of Utah were used to determine whether there might have been an association between the occurrence of soft tissue cancer and bone tumor (skeletal malignancy) among the dogs injected with bone-seeking radionuclides. In addition to comparing the numbers of animals with and without bone tumors and with and without soft tissue cancers, data on bone sarcomas and soft tissue sarcomas were compared. Longevity (postinjection survival) of the dogs was investigated. It appeared that survival (time between radionuclide injection and death) was important in the eventual expression of malignancies. There could not be established a possible susceptibility to skeletal malignancy associated with the occurrence of soft tissue cancer (or soft tissue sarcoma). We concluded that, although the literature reports an increased susceptibility for subsequent malignancies for individuals with naturally-occurring or radiation-induced cancer, the data derived from this study do not confirm the concept that the appearance of soft tissue cancer is strongly associated with an increased risk of developing a radionuclide-induced skeletal malignancy.
authors.affiliation: Radiobiology Division, Department of Radiology, University of Utah, 729 Arapeen Drive, Suite 2334, Salt Lake City, UT 84108-1218, USA. ray.lloyd@hsc.utah.edu
authors.forename: Ray D
authors.initials: RD
authors.lastname: Lloyd
authors.forename: Glenn N
authors.initials: GN
authors.lastname: Taylor
authors.forename: Scott C
authors.initials: SC
authors.lastname: Miller
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology*; D004285:Dogs; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D011868:Radioisotopes; D012307:Risk Factors; D012509:Sarcoma / Q000150:complications* / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000150:complications*; D016019:Survival Analysis
chemical_list: D011868:Radioisotopes