Microvessel density in alveolar ridge regeneration with autologous and alloplastic bone.
OBJECTIVE
The purpose of this study was to conduct a comparative immunohistochemical evaluation of microvessel density (MVD) in alveolar sites augmented with autologous bone or Bio-Oss.


METHODS
Eighteen patients participated in this study. All patients presented maxillary ridge defects. These defects were filled in a random fashion with autologous bone or Bio-Oss. Endosseous implants were inserted after a mean of 3 months in the sites augmented with autologous bone and after a mean of 6 months in the sites augmented with Bio-Oss. As part of the implant site preparation, a trephine was used to harvest bone cores. As control, bone cores retrieved in nonaugmented sites were used. The mean value of MVD in control bone was 25.6 +/- 3.425. In the sites augmented with autologous bone, the MVD was 29.8 +/- 4.4, while in the sites regenerated with Bio-Oss, the MVD was 29.7 +/- 2.4. The statistical analysis showed that the difference in MVD between control bone and autologous bone (P = 0.057) and between control bone and Bio-Oss (P = 0.023) was statistically significant. The difference between the sites regenerated with autologous bone and those regenerated with Bio-Oss was not significant (P = 0.6889).


CONCLUSIONS
Our results show that both sites augmented with autologous bone and Bio-Oss presented a higher and statistically significant quantity of microvessels compared with control specimens. No significant differences were found when comparing the MVD of the sites regenerated with autologous bone and those regenerated with Bio-Oss. The retrieval time was, however, a mean of 3 months for the autologous bone sites and a mean of 6 months for the Bio-Oss sites. These data could support the hypothesis of faster healing for the sites augmented with autologous bone.
Piattelli
Adriano
A
Dental School, University of Chieti, Italy. apiattelli@unich.it
Degidi
Marco
M
Di Stefano
Danilo Alessio
DA
Rubini
Corrado
C
Fioroni
Massimiliano
M
Strocchi
Rita
R
D000328:Adult; D000539:Alveolar Process / Q000098:blood supply*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001853:Bone Marrow / Q000098:blood supply; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000473:pathology* / Q000502:physiology; D004396:Coloring Agents; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006253:Haversian System / Q000098:blood supply; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D013223:Statistics as Topic; D014182:Transplantation, Autologous
C077540:Bio-Oss; D018786:Bone Substitutes; D004396:Coloring Agents; D015921:Dental Implants; D008903:Minerals