title: Hyperhomocysteinemia is related to a decreased blood level of vitamin B12 in the second and third trimester of normal pregnancy.
abstract: Hyperhomocysteinemia has been associated with several pregnancy complications. We have investigated the variation of plasma total homocysteine (tHcys) during the 2 last trimesters of normal pregnancy and related it to blood vitamin B12 and folate and to the excretion of the degraded intrinsic factor receptor (IFCR) in urine, in a follow-up study of 15 cases. A significant rise in tHcys was observed between the beginning of the second trimester and the third trimester with respective values (median) 6.1, 5.8 and 6.7 micromol/l (p = 0.038). The tHcys/albumin ratio also increased significantly, while no correlation was found between albumin and folate blood concentration. In contrast, a significant decrease in vitamin B12 was observed (279, 225 and 199 pmol/l, between the 4th and 6th, and the 6th and 9th month, respectively (p = 0.017-0.002)). A significant negative correlation was found between tHcys between the 4th and 9th month of pregnancy and the ratio of vitamin B12 between the 4th and 9th month of pregnancy (r = 0.55, p = 0.037). The urine excretion of IFCR was increased and was not related to vitamin B12 and tHcys. In conclusion, we have observed a rise in tHcys between the beginning of the second trimester and the third trimester of pregnancy which was related to the decreased blood level of vitamin B12. Subclinical deficiency of vitamin B12 should be further investigated in pregnant women who remain on inadequate diet.
authors.affiliation: Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition, Equipe INSERM 00-14, Université Henri Poincaré, Nancy, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Chéry
authors.forename: Françoise
authors.initials: F
authors.lastname: Barbé
authors.forename: Catherine
authors.initials: C
authors.lastname: Lequere
authors.forename: Idrissia
authors.initials: I
authors.lastname: Abdelmouttaleb
authors.forename: Philippe
authors.initials: P
authors.lastname: Gérard
authors.forename: Patricia
authors.initials: P
authors.lastname: Barbarino
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Boutroy
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Guéant
mesh_terms: D000328:Adult; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D007437:Intrinsic Factor / Q000652:urine; D011247:Pregnancy / Q000097:blood*; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D018000:Receptors, Peptide / Q000378:metabolism; D013223:Statistics as Topic; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D018000:Receptors, Peptide; C028199:intrinsic factor receptor; D006710:Homocysteine; D007437:Intrinsic Factor; D005492:Folic Acid; D014805:Vitamin B 12