[Influence of monkshood root-peony root combination on inflamation-induced agents and free radicals].
OBJECTIVE
To find out the effect of monkshood root and peony root on inflammation-induced agents and free radicals when used separately and in combination.


METHODS
Two drugs were made into decoctions separately and in combination, i.p., qd, for 7 d, red blood cell SOD and serum LPO were analysed and the anti-inflammatory actions were observed.


RESULTS
In an experimental rat model with inflamed paw edema induced by carrageenin or formaldehyde and in a mouse model with ear swelling induced by xylene, the anti-inflammatory effect appeared stronger when the two drugs were used in combination, especially in comparison with the use of monkshood root alone. The exudation of blood capillaries and the contents of inflammation medium PGE2 were lowered; The activity of SOD extracted from rat or mouse red blood cells was enhanced, and the serum LPO, which was high in level when monkshood root was used alone, could be declined when the two drugs were used in combination.


CONCLUSIONS
The drug combination is more effective in inhibiting inflammation and scavenging free radicals.
Qin
L
L
Shandong University of TCM, Jinan 250014, Shandong, China.
Peng
X
X
Zhang
S H
SH
Wang
L
L
Liu
F
F
D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase; D015232:Dinoprostone