title: Dose-position and dose-volume histogram analysis of standard wedged and intensity modulated treatments in breast radiotherapy.
abstract: The aim of this work was to evaluate the positional distribution of dose in a concise manner and to analyse dose-histogram results in tangential breast radiotherapy in 300 patients, randomized to standard wedged or intensity modulated radiotherapy (IMRT), for future correlation with clinical outcome data. A simple method for analysing the dose-position relationship in the treatment volume was used to compare the spatial distribution of dose in patients. The breast was divided into equal thirds (upper, middle and lower) and dose was assessed using three dose bands; 95-105%, >105-110% and >110% of the prescription dose. The effect of using IMRT on the dosimetry was assessed from dose-volume histogram data using the following parameters: percentage of the target volume receiving a dose less than 95%, greater than 105%, either less than 95% or greater than 105% of that prescribed; the mean dose; and the maximum dose. Doses greater than 105% were predominantly in the upper and lower regions of the breast in the standard wedged treatment. 96% of these patients received doses greater than 105% in the upper region of the breast and 70% received doses greater than 105% in the lower breast. Only 4% of patients allocated IMRT received doses greater than 105% in either region. Analysis of dose-volume histogram data showed that IMRT reduced the volume receiving a dose greater than 105% by a mean of 10.7% (p= or <0.001); the mean change in the volume receiving a dose less than 95% was 0.2% (p=0.63). Average mean plan dose was 101.6% for standard treatment and 99.6% for IMRT (p<0.001 for each compared with 100.0% ideal). The mean value of maximum dose was reduced from 111% to 106% in the group of patients randomized to IMRT. A simple method for describing the relationship between dose and position in the breast, which is helpful for the effective correlation of dosimetry and clinical effects, is reported. Further, application of IMRT to the tangential field irradiation of the breast has been demonstrated to reduce high dose regions in both volume and dose level without compromising either minimum dose coverage or mean dose delivered to the breast.
authors.affiliation: Joint Department of Physics, Royal Marsden NHS Trust and Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Donovan
authors.forename: N J
authors.initials: NJ
authors.lastname: Bleackley
authors.forename: P M
authors.initials: PM
authors.lastname: Evans
authors.forename: S F
authors.initials: SF
authors.lastname: Reise
authors.forename: J R
authors.initials: JR
authors.lastname: Yarnold
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D016896:Treatment Outcome