title: Novel drug delivery device using silicone: controlled release of insoluble drugs or two kinds of water-soluble drugs.
abstract: Drug release mechanism from silicone carrier differs depending on physicochemical properties of the drug. So far, there have been few reports on controlled release of insoluble drug and on simultaneous release of two kinds of water-soluble drugs. The purposes of this study are to establish methods for (1). continuous release of insoluble drug, and (2). release of two kinds of water-soluble drugs from silicone carrier. Polystyrene beads (PSTB) and proteins such as interferon (IFN) and human serum albumin (HSA) were used as model drugs. PSTB was released from silicone only when citric acid (CA) and sodium bicarbonate (SB) existed as additives. The release patterns of IFN and HSA were almost same in the case of matrix and covered-rod formulations, but double-layered formulation released them in different patterns. As far as we are aware, this is the first report on the release of insoluble drug from silicone and the controlled release of two kinds of water-soluble drugs.
authors.affiliation: Research Division, Sumitomo Pharmaceuticals Co, Ltd, Osaka, Japan. kajihara@sumitomopharm.co.jp
authors.forename: Masako
authors.initials: M
authors.lastname: Kajihara
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sugie
authors.forename: Hiroo
authors.initials: H
authors.lastname: Maeda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sano
authors.forename: Keiji
authors.initials: K
authors.lastname: Fujioka
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Urabe
authors.forename: Masao
authors.initials: M
authors.lastname: Tanihara
authors.forename: Yukio
authors.initials: Y
authors.lastname: Imanishi
mesh_terms: D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D012828:Silicones / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012995:Solubility
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012828:Silicones