Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis.
Lymphoepithelioma-like carcinoma (LELC) is an Epstein-Barr virus (EBV) related malignancy. It is not a common condition and is usually found in the head and neck region. We describe the development of LELC involving the parotid gland in a patient with rheumatoid arthritis (RA) who had been receiving long-term azathioprine. A brief review is also made on the clinical presentation and histological features of LELC and the association of RA with EBV related diseases. The latter may be attributed to an increase in risk of malignancy associated with RA or as a result of the long-term immunosuppressive used.
Mok
M Y
MY
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Shek
W H
WH
Wong
R W S
RW
D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D017403:In Situ Hybridization; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology / Q000821:virology*; D016601:RNA-Binding Proteins / Q000032:analysis; D012269:Ribosomal Proteins
D018501:Antirheumatic Agents; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human; D001379:Azathioprine