A DNA damage checkpoint in Escherichia coli.
An early attempt to find out if the DNA double helix is actively unwound before being replicated was not conclusive, but it did disclose the existence of a unique moment in the life cycle of Escherichia coli when the cell registers whether or not its DNA is intact. If not, the cell embarks on rapid breakdown of its DNA, like "apoptosis" in eukaryotic cells.
Cairns
John
J
Clinical Trial Service Unit, Harkness Building, The Radcliffe Infirmary, Oxford, UK. j.cairns@ctsu.ox.ac.uk
D002453:Cell Cycle; D004249:DNA Damage; D004261:DNA Replication; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics
D004269:DNA, Bacterial