[Formulation of advancing products of pulmonary medicine absorption].
The author introduces the various possibilities of the production of medical aerosols ensuring pulmonary absorption. He also mentions the method of selecting the auxiliary materials formulated with propellants, and describes the characteristics of norfluran Dymel 134 and apafluran HFC 227. In the experimental section, he handles the development of an anxiolitic byciclo-heptane-type aerosol, for which the aim was to develop a homogeneous liquid-phase aerosol. For this he used a Freon 12/114 mixture and Dymel 134 propellants in a solvent mixture of ethanol and ethanol-propylene glycol. The solubility of byciclo-heptane could be significantly improved with beta-cyclodextrine. The formation of enclosure complex can be proved by IR spectrum, and the complete dissolution was furthered by the OH groups of the auxiliary material.
Stampf
György
G
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest Hógyes Endre u 7.-1092.
D000042:Absorption; D000336:Aerosols; D000431:Ethanol; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism*; D019946:Propylene Glycol; D012997:Solvents; D013329:Structure-Activity Relationship; D004980:Ethane / Q000031:analogs & derivatives; D005466:Fluorocarbons
D000336:Aerosols; D000431:Ethanol; D006845:Hydrocarbons, Fluorinated; D019946:Propylene Glycol; D012997:Solvents; C063006:norflurane; D004980:Ethane; D005466:Fluorocarbons