Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants.
Oral thrush is a common condition in young infants. Nystatin treatment is associated with frequent recurrences and difficulty in administration. Fluconazole was compared with nystatin for the treatment of oral candidiasis in infants. Thirty-four infants were randomized to either nystatin oral suspension four times a day for 10 days or fluconazole suspension 3 mg/kg in a single daily dose for 7 days. Clinical cures for nystatin were 6 of 19 (32%), and those for fluconazole were 15 of 15 (100%), P < 0.0001. In this small pilot study fluconazole was shown to be superior to nystatin suspension for the treatment of oral thrush in otherwise healthy infants.
Goins
R Alan
RA
Wilford Hall USAF Medical Center, San Antonio, TX, USA.
Ascher
David
D
Waecker
Norman
N
Arnold
John
J
Moorefield
Ebony
E
D000284:Administration, Oral; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000008:administration & dosage*; D002180:Candidiasis, Oral / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009761:Nystatin / Q000008:administration & dosage*; D011336:Probability; D011446:Prospective Studies; D016896:Treatment Outcome
D000935:Antifungal Agents; D009761:Nystatin; D015725:Fluconazole