[Research on breast cancer susceptibility genes].
With the increasing of the incidence rate of breast carcinoma year after year, the susceptibility genes of breast carcinoma was paid more and more attention. The study on susceptibility genes play an important role in early diagnosis and prevention for the individuals with family history of breast carcinoma, elucidation of pathologic mechanism of sporadic breast carcinoma, early diagnosis and adjudging prognosis, research on drug sensitivity, differential diagnosis of benign and malignant disease, etc. There were many studies on the high-penetrance susceptibility genes (BRCA1, BRCA2). However, some low-penetrance susceptibility gene, for example, the members of hormone metabolism related enzymes genes CYP family (CYP17, CYP19, CYP1A1, etc.), the carcinogen metabolism related gene (GSTM1, NAT1, NAT2), and DNA damage repair gene (ATM) were not clearly understood. The aim of this study was to review the present research situation of common susceptibility genes of breast carcinoma found already.
Ye
Jing
J
Research Center, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, P. R. China.
Shan
Bao-en
BE
D001141:Aromatase / Q000235:genetics; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D012106:Research / Q000639:trends; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics
D001141:Aromatase; D001191:Arylamine N-Acetyltransferase; D019313:BRCA1 Protein; D024682:BRCA2 Protein; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D007527:Isoenzymes; D013254:Steroid 17-alpha-Hydroxylase; C089384:N-acetyltransferase 1; C478900:NAT2 protein, human