Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma.
The expression of mRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's mRNA (P < 0.005), but there was no significant relationship between its expression and the one-year survival of the cats.
Tanabe
S
S
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
Nakadai
T
T
Furuoka
H
H
Oomachi
T
T
Kobayashi
Y
Y
Omata
Y
Y
Koyama
T
T
Hondo
E
E
Uzuka
Y
Y
Sarashina
T
T
Ducusin
R J T
RJ
Shida
T
T
Dorf
M E
ME
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001483:Base Sequence; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D002371:Cat Diseases / Q000378:metabolism* / Q000473:pathology; D002415:Cats; D005260:Female; D017403:In Situ Hybridization / Q000662:veterinary; D015674:Mammary Neoplasms, Animal / Q000378:metabolism* / Q000473:pathology; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D019718:Receptors, CXCR4 / Q000096:biosynthesis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016019:Survival Analysis
D012333:RNA, Messenger; D019718:Receptors, CXCR4