title: Electrocochleography and intranasal allergen challenge as investigational tools in patients with inhalant allergy and Ménière's disease.
abstract: OBJECTIVE
  To expand on a prior study investigating the relation between inhalant allergy and Ménière's disease using electrocochleography and to present data from five patients heretofore unmentioned in previous reports.
  
  
  METHODS
  Prospective study of five patients identified with Ménière's disease and inhalant allergy in the practices of two faculty otolaryngologists.
  
  
  METHODS
  Patients were tested twice using electrocochleography: once as a baseline and again 20 minutes following intranasal challenge with the allergen to which they were most sensitive.
  
  
  RESULTS
  Three patients had no prior history of immunotherapy, and all were found to have a >15% increase in summating potential (SP)/action potential (AP) ratio after antigen challenge. However, only one of these patients developed audiovestibular symptoms. Two patients had a history of immunotherapy. One of these patients was tested using three different antigens to which she was highly sensitive on skin testing, one of which provoked audiovestibular symptoms on environmental exposure. Postchallenge electrocochleography, however, demonstrated normal SP/AP ratios with only one antigen causing a >15% increase. The other patient had elevated SP/AP ratios both before and after challenge and developed no audiovestibular symptoms despite a >15% increase.
  
  
  CONCLUSIONS
  Previous work using this investigational tool has identified that all patients with a normal electrocochleography were asymptomatic from an audiovestibular standpoint at the time of postchallenge testing. An elevated SP/AP was not reliably correlated with audiovestibular symptoms in this group of patients. Further investigation in this area will examine the utility of using the variability of the SP and AP to predict audiovestibular symptoms.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas 75390-9035, USA.
authors.forename: Debbie A
authors.initials: DA
authors.lastname: Eaton
authors.forename: Peter S
authors.initials: PS
authors.lastname: Roland
authors.forename: Richard L
authors.initials: RL
authors.lastname: Mabry
authors.forename: Angela G
authors.initials: AG
authors.lastname: Shoup
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D001300:Audiometry, Evoked Response / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D009299:Nasal Provocation Tests / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*; D012494:Sampling Studies; D012680:Sensitivity and Specificity
chemical_list: D000485:Allergens