Cytokinesis: relative alignment of the cell division apparatus and the mitotic spindle.
The cell division apparatus is assembled at different stages of the cell cycle in different eukaryotic organisms. Mechanisms exist in all organisms, however, to ensure that the cell division apparatus and the mitotic spindle are aligned perpendicular to each other. Such an alignment ensures that each daughter cell receives a nucleus and that the cell division apparatus does not cleave and destroy the genetic material. The interaction(s) of astral microtubules with the cell cortex appears to play an important role in establishing perpendicularity between chromosome segregation and cell division machinery.
Wang
Hongyan
H
Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore 117604, Singapore.
Oliferenko
Snezhana
S
Balasubramanian
Mohan K
MK
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D020409:Molecular Motor Proteins; D008941:Spindle Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D015003:Yeasts / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure
D020409:Molecular Motor Proteins