title: One step closer to a sweet conclusion.
abstract: OtsA is required for the biosynthesis of trehalose, a nonreducing disaccharide that is important for bacterial survival and stress responses. In this issue of Chemistry & Biology, the structure of OtsA is uncovered and reveals an unexpected relationship between the enzyme's structure and function.
authors.affiliation: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, Canada BC V6T 1Z1.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Withers
authors.forename: Warren W
authors.initials: WW
authors.lastname: Wakarchuk
authors.forename: Natalie C J
authors.initials: NC
authors.lastname: Strynadka
mesh_terms: D001665:Binding Sites; D005964:Glucosyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase