[Is buprenorphine a potential alternative to methadone for treating pregnant drug users? Inventory of clinical data in the literature].
In this review of the literature, we collected 102 case reports of newborns exposed in utero to buprenorphine between 1996 and 2000. Reported data show that infants born to a mother taking buprenorphine are delivered at term and have a birth weight close to infants not exposed to these substances. The published data also showed that observations have varied concerning the frequency, intensity, and duration of the withdrawal syndrome in newborns exposed in utero to buprenorphine.
Loustauneau
Anne
A
Unité de Soins d'Addictologie, Service Universitaire de Psychiatrie, CHU de Bordeaux, Bordeaux.
Auriacombe
Marc
M
Daulouede
Jean-Pierre
JP
Tignol
Jean
J
D002047:Buprenorphine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008691:Methadone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009294:Narcotics / Q000627:therapeutic use*; D009357:Neonatal Abstinence Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D019966:Substance-Related Disorders / Q000188:drug therapy*
D009292:Narcotic Antagonists; D009294:Narcotics; D002047:Buprenorphine; D008691:Methadone