Effects of glucocorticoids on the skeleton.
Glucocorticoids have profound effects on mineral metabolism and skeletal cell function, and an excess can lead to the development of short stature and osteoporosis. The most significant actions of glucocorticoids are on chondrocytes and bone-forming cells, where they act, directly and indirectly, and regulate the local synthesis of insulin-like growth factor-I.
Canalis
Ernesto
E
Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105-1299, USA. ecanalis@stfranciscare.org
Pereira
Renata C
RC
Delany
Anne M
AM
D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics; D019902:Chondrocytes / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000235:genetics; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology; D010024:Osteoporosis; D011401:Promoter Regions, Genetic
D022763:CCAAT-Enhancer-Binding Protein-alpha; D005938:Glucocorticoids; D007334:Insulin-Like Growth Factor I