Targeted topical peripheral analgesics in the management of pain.
The term "targeted peripheral analgesics" has been developed to describe analgesics whose mechanism of action appears to be primarily through reducing pain transmission within the peripheral nervous system. Key differences between targeted peripheral and systemic analgesics and the difference between topical and transdermal analgesics are discussed. A review of the clinical conditions that have reportedly responded to targeted peripheral analgesics is described in detail in this article.
Argoff
Charles E
CE
Cohn Pain Management Center, North Shore-Long Island Jewish Health System, 4300 Hempstead Turnpike, Bethpage, NY 11714, USA. pargoff@optonline.net
D000287:Administration, Topical; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D006801:Humans; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D017288:Pain Threshold / Q000187:drug effects; D017933:Peripheral Nervous System / Q000187:drug effects*
D000700:Analgesics