[Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats].
To investigate the effects of fluoride on DNA damage as well as the effects of selenium and zinc against fluoride respectively or jointly in pallium neural cells of rats, single cell gel electrophoresis was used to detect the DNA damage of neural cells prepared in vitro. The results showed that the degree of DNA damage in the fluoride group and the selenium group were significantly greater than that in control group(P < 0.01). The damage in the fluoride group was even more serious. The damage in the fluoride + selenium group and fluoride + zinc group was slighter than that in the fluoride group but with no significant difference. The extent of DNA damage in the fluoride + selenium + zinc group was significantly slighter than that in the fluoride group(P < 0.05). It suggested that fluoride and selenium could induce DNA damage in pallium neural cells of rats respectively. Moreover, the joint antagonistic effect of selenium and zinc against fluoride was more obvious.
Chen
J
J
Department of Environmental Health, Tongji Medical University, Wuhan 430030, China.
Chen
X
X
Yang
K
K
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology; D004249:DNA Damage / Q000187:drug effects*; D004357:Drug Synergism; D005459:Fluorides / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D012643:Selenium; D015032:Zinc; D005459:Fluorides