[The role of human herpesvirus-8 infection in the pathogenesis of multiple myeloma].
Multiple myeloma is a B-cell neoplasm characterized by abnormal proliferation and accumulation of monoclonal plasma cells in the bone marrow. Recently some laboratories have detected human herpesvirus-8 (HHV-8) DNA sequences in bone marrow dendritic cells from myeloma patients. It has been suggested that the cytokines expressed by HHV-8 gene, such as vIRF, vIL-8R and vIL-6, may play a role in the pathogenesis of multiple myeloma. However, the majority of European investigators failed to find evidence to confirm this observation. It remains unclear whether HHV-8 is consequentially associated with myeloma or only a regional opportunistic infection. Controversy still focuses on the role of specific HHV-8 strains involved in pathogenesis of multiple myeloma and causality between the
Zhang
Chun-Yang
CY
Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.
D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000378:metabolism / Q000821:virology; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000378:metabolism / Q000821:virology*; D016036:Seroepidemiologic Studies
D016207:Cytokines