[Effect of heroin-containing substances on the infectivity of the human immunodeficiency virus type 1 in vitro].
At room temperature, HIV-1 IIIB is shown to remain infectious in a dose of 25 mg/ml of heroin solution for more than 8 days. The large batch of HIV-1-contaminated heroin solution may therefore remain infectious for a long period sufficient for transportation, packing, and sale in any area of Russia. At the same time 41-day incubation under the same conditions caused a complete loss of viral infectivity. Under certain conditions (the concentration of MT-4 cells being less than 2 x 105 cells/ml and the multiplicity of infection, less than 0.01 ID50/cell), heroin was demonstrated to be able to increase HIV-1 replication at the early stages of its life cycle. The findings should be borne in mind in elaborating measures to prevent the spread of HIV-1 among intravenous psychoactive drug users.
Selimova
L M
LM
Khanina
T A
TA
Kazennova
E V
EV
Zverev
S Ia
SIa
Pokrovskiĭ
V V
VV
Bobkov
A F
AF
D002460:Cell Line; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D003932:Heroin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015819:Substance Abuse, Intravenous; D014774:Virulence / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D003932:Heroin