The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups.
In the present study, neuroprotective effect of Lavandula angustifolia flower aqueous extract in glutamate-induced neurotoxicity in rat pups cerebellar granular cell culture was investigated. The extract at doses of 10 microg ml(-1), 100 microg ml(-1), 1 mg ml(-1) and 10 mg ml(-1) was applied to culture flasks. The extract at doses of 100 microg ml(-1) and 1 mg ml(-1) significantly blocked glutamate-induced neurotoxicity, with the most effective dose being 1 mg ml(-1). On the other hand, 10 mg ml(-1) dose of extract increased the dead cell with respect to glutamate group, despite being found insignificant statistically. As a result, L. angustifolia protected the neurons against glutamate toxicity.
Büyükokuroğlu
Mehmet Emin
ME
Department of Pharmacology, Medical Faculty, Atatürk University, Tr-25240 Erzurum, Turkey. memin@atauni.edu.tr
Gepdiremen
Akçahan
A
Hacimüftüoğlu
Ahmet
A
Oktay
Münir
M
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology*; D004305:Dose-Response Relationship, Drug; D035264:Flowers / Q000737:chemistry*; D018698:Glutamic Acid / Q000633:toxicity*; D027523:Lavandula / Q000737:chemistry*; D009474:Neurons / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D018698:Glutamic Acid