Cognitive and behavioral deficits in premature graduates of intensive care.
A substantial number of VLBW graduates of intensive care develop cognitive and behavioral problems, even in the absence of neuroimaging abnormalities. Although this article has highlighted the potential, important, contributing role of medical and stressful, neonatal, environmental conditions to the development of these deficits, it is not all-encompassing, and there are additional prenatal (ie, in utero stress, drug exposure) and neonatal (ie, infectious) contributing factors. The long-term, outcome data presented in this article are pertinent to the more mature, VLBW infant, and it remains unclear and critically important to delineate the long-term, neurobehavioral outcome of those extremely low birth-weight survivors born at the cutting limit of viability.
Perlman
Jeffrey M
JM
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA. jeffrey.perlman@utsouthwestern.edu
D001479:Basal Ganglia / Q000254:growth & development / Q000293:injuries; D001921:Brain / Q000254:growth & development; D015984:Causality; D002653:Child Behavior Disorders / Q000209:etiology* / Q000517:prevention & control; D003072:Cognition Disorders / Q000209:etiology* / Q000517:prevention & control; D002658:Developmental Disabilities / Q000209:etiology* / Q000517:prevention & control; D006272:Health Facility Environment / Q000592:standards; D006624:Hippocampus / Q000254:growth & development / Q000293:injuries; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D019102:Infant, Very Low Birth Weight; D015931:Intensive Care, Neonatal / Q000379:methods / Q000592:standards; D009622:Noise / Q000009:adverse effects; D002666:Psychology, Child; D016896:Treatment Outcome