title: Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens.
abstract: Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.
authors.affiliation: Department of Laboratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan. akahoshi@med.kitasato-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Akahoshi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasahara
authors.forename: Rie
authors.initials: R
authors.lastname: Namai
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Matsui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watabe
authors.forename: Hidero
authors.initials: H
authors.lastname: Kitasato
authors.forename: Matsuhisa
authors.initials: M
authors.lastname: Inoue
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Kondo
mesh_terms: D054418:Chemokine CCL20; D019742:Chemokines, CC / Q000096:biosynthesis* / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000276:immunology*; D006094:Gram-Positive Bacteria / Q000276:immunology*; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D054399:Receptors, CCR6; D019707:Receptors, Chemokine
chemical_list: C108355:CCL20 protein, human; C106311:CCR6 protein, human; D054418:Chemokine CCL20; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; D054399:Receptors, CCR6; D019707:Receptors, Chemokine