Alteration of functional neuroanatomy of simple object memory in medial temporal lobe epilepsy patients.
Using H2 15O PET, we examined the neuroanatomy associated with a simple form of episodic memory in patients with right or left medial temporal lobe epilepsy and normal healthy controls. When line drawings of common objects were memorized and tested after a 30 min delay, no behavioral difference was found between the patient groups and the controls. However, the patients with epilepsy showed greater cortical activations than the control group on the side ipsilateral to the epileptic focus. rCBF in the anterior thalamic region was enhanced in patients relative to the control group. The results showed that long-term dysfunction of the medial temporal lobe might reinforce alternative memory pathways and recruit a distributed cortical network ipsilateral to their epilepsy focus.
Kang
Eunjoo
E
Institute of Radiation Medicine, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
Nam
Hyunwoo
H
Lee
Dong Soo
DS
Lee
Sang Kun
SK
Lee
Kyoung-Min
KM
Park
Seong-Ho
SH
Lee
Jae Sung
JS
Chung
Jun-Key
JK
Lee
Myung Chul
MC
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity; D021641:Recognition, Psychology / Q000502:physiology*; D013788:Thalamus / Q000502:physiology; D014055:Tomography, Emission-Computed