title: Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease.
abstract: In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with PD and control subjects. The concentration of 8-OHG in CSF in PD patients was approximately three-fold that in controls (P < 0.001). The concentration of 8-OHG in CSF decreased significantly with the duration of disease (r(s) = -0.46, P < 0.05). However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls. In addition, the concentration of 8-OHG in CSF showed no correlation with that in serum in both the controls and PD patients suggesting that the 8-OHG concentrations in the CSF do not reflect those in serum and may be probably reflect those in brain tissue. These in vivo findings suggest a possible role of 8-OHG and increased oxidative RNA damage in the early stage of the development of PD.
authors.affiliation: Department of Neurology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe
authors.forename: Chiaki
authors.initials: C
authors.lastname: Isobe
authors.forename: Takahiko
authors.initials: T
authors.lastname: Murata
authors.forename: Chigumi
authors.initials: C
authors.lastname: Sato
authors.forename: Hideo
authors.initials: H
authors.lastname: Tohgi
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006151:Guanosine / Q000031:analogs & derivatives* / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood* / Q000134:cerebrospinal fluid*; D012313:RNA / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D006151:Guanosine; C046215:8-hydroxyguanosine; D012313:RNA