Photoreaction generating active oxygens of In(3+)-tetrakis(4-methylpyridyl)-porphine in the presence of albumins.
The complex formation of In(3+)-tetrakis(4-N-methylpyridyl)-porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In(3+) through the -S(-) group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.
Mifune
Masaki
M
Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan. mifune@pharm.okayama-u.ac.jp
Asahara
Hatsuki
H
Hinokiyama
Toyohiro
T
Liu
Jian
J
Akizawa
Hiromichi
H
Iwado
Akimasa
A
Motohashi
Noriko
N
Saito
Yutaka
Y
D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D012709:Serum Albumin / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013481:Superoxides / Q000737:chemistry; D014466:Ultraviolet Rays
C474098:In(III)-tetrakis(4-methylpyridyl)-porphine; D008665:Metalloporphyrins; D012709:Serum Albumin; D013481:Superoxides; D010100:Oxygen