[The update achievements on the relation between free radical and leukemia].
Free radicals are a group of charged atoms, molecules or ions with strong biological activity, which play an important role in pathogenesis of cancers and many other diseases. Free radicals are produced and consumed by a serial of chain reactions. Free radicals can activate pro-oncogenes, impact the signal transduction about the apoptosis, survival and proliferation of tumor cells modify the key enzymes or proteins functions, and might cause carcinogenesis. Meanwhile, free radicals damage the tissues and organs and bring about a variety of pathological changes. On the other hand, free radicals are involved in the effects of some anti-leukemic drugs as intermediates or functional substances.
Xu
Fang
F
Division of Hematology, West China Hospital of Sichuan University, Chengdu 610041, China.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D000970:Antineoplastic Agents; D005609:Free Radicals; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species