[Some molecular-biological and immunological aspects of Aleutian disease of mink].
Information on the development of the infectious process in the Aleutian disease of minks (ADM) on the molecular level, are updated. In particular, the decisive role played by the ABM virus infection of the cells of the immune system (B lymphocytes, macrophages, follicular dendritic cells) and the possible involvement of the mechanism of the antibody-dependent aggravation of this infection are pointed out. In addition, the role of the weak ADM virus promoter p36, the immune status of minks and their age in the determination of the acute or "slow" character of the course of the disease are considered.
Faĭzuloev
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EB
Andzhaparidze Research Institute of Viral Preparations, Moscow, Russia.
D000367:Age Factors; D000453:Aleutian Mink Disease / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D000454:Aleutian Mink Disease Virus / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D019067:Antibody-Dependent Enhancement; D001402:B-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D015967:Gene Expression Regulation, Viral / Q000276:immunology; D007111:Immunity, Cellular / Q000502:physiology; D015850:Interleukin-6 / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008907:Mink; D011401:Promoter Regions, Genetic / Q000276:immunology
D000914:Antibodies, Viral; D015850:Interleukin-6