Controlling calcium entry.
Ca(2+) enters cells through an assortment of Ca(2+)-permeable channels that respond to different stimuli and couple to different cellular responses. Several different Ca(2+) entry pathways can be activated by receptors that stimulate phospholipase C (PLC). Both limbs of this signaling pathway (IP(3) and diacylglycerol), PLC itself, and its substrate (PIP(2)) contribute to the coordinate regulation of these Ca(2+) entry pathways.
Taylor
Colin W
CW
Department of Pharmacology, Tennis Court Road, CB2 1PD, Cambridge, United Kingdom. cwt1000@cam.ac.uk
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism; D006868:Hydrolysis; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D008564:Membrane Potentials; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism*
D004075:Diglycerides; D019269:Phosphatidylinositol 4,5-Diphosphate; D015544:Inositol 1,4,5-Trisphosphate; D010738:Type C Phospholipases; D002118:Calcium