Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion.
An amphiphilic copolymer, Pluronic F127, has been deposited, by adsorption, to the skin of human volunteers and the ability of the coated skin to resist bacterial colonisation has been evaluated. In parallel, the ability of the same copolymer to act as a bacterial release agent has been evaluated. In both cases, F127 proved to be of little added value in formulations designed to suppress the bacterial colonisation of human skin.
Marsh
Lorraine H
LH
School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.
Alexander
Cameron
C
Coke
Mark
M
Dettmar
Peter W
PW
Havler
Michael
M
Nevell
Thomas G
TG
Smart
John D
JD
Timmins
Barry
B
Tsibouklis
John
J
D000327:Adsorption / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D020442:Poloxamer / Q000493:pharmacokinetics* / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*
D020442:Poloxamer