Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria.
Penetration of cerebrospinal fluid (CSF) by artesunate and DHA was assessed in six adults with cerebral or severe malaria. Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing.
Davis
Timothy M E
TM
Tropical Diseases Research Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam. tdavis@cyllene.uwa.edu.au
Binh
Tran Quang
TQ
Ilett
Kenneth F
KF
Batty
Kevin T
KT
Phuöng
Hoang Lan
HL
Chiswell
Gregory M
GM
Phuong
Vu Duong Bich
VD
Agus
Cindy
C
D000293:Adolescent; D000328:Adult; D037621:Artemisinins / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000077332:Artesunate; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D016779:Malaria, Cerebral / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics* / Q000627:therapeutic use
D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol