[Expression of Bcl-2 and Bax proteins in liver tissues of chronic viral hepatitis].
In order to study the significance of expression of Bcl-1 and Bax proteins in the liver tissues, 35 cases of chronic viral hepatitis (CH) were immunohistochemically studied. The results showed that Bcl-2 and Bax were mainly colocated in cytoplasm of the mononuclear cells(MN) in the areas of focal necrosis, bridging necrosis and piecemeal necrosis (PN). Some hepatocytes surrounding these areas expressed Bcl-2 and Bax or expressed Bax only. Pathological examination found that these hepatocytes Suffered from hydropic or acidophilic degeneration. In the severe viral hepatitis, survival hepatocytes also expressed Bcl-2 and Bax. It is suggested that the expression of Bcl-2 and Bax in the liver tissues correlated with the apoptosis of hepatocytes in CH and influenced the progress of severe viral hepatitis.
Xin
S
S
302 Hospital of PLA, Beijing 100039.
Zhao
J
J
Wang
S
S
D000328:Adult; D017209:Apoptosis; D005260:Female; D019694:Hepatitis B, Chronic / Q000378:metabolism* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein