title: The liver in other (nondiabetic) endocrine disorders.
abstract: The liver has a major role in the proper maintenance of intermediate metabolism and endocrine homeostasis. It contains enzymes that are essential for hormonal biotransformation and the regulation of numerous metabolic reactions, which control hormone metabolism. The liver also manufactures several proteins, which carry circulating hormones to their effector sites. The endocrine system exerts tight control of the metabolic reactions within the liver, which also can be disturbed by endocrine disorders. These types of interactions and the effects of the exogenous hormones and the drugs that are used as treatment for hormonal disorders are discussed.
authors.affiliation: Division of Gastroenterology, Robert Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
authors.forename: Wael I
authors.initials: WI
authors.lastname: Youssef
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Mullen
mesh_terms: D003480:Cushing Syndrome / Q000150:complications*; D004967:Estrogens / Q000502:physiology; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006980:Hyperthyroidism / Q000150:complications*; D007037:Hypothyroidism / Q000150:complications*; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism; D013739:Testosterone / Q000502:physiology
chemical_list: D004967:Estrogens; D019382:Human Growth Hormone; D013739:Testosterone; D006854:Hydrocortisone