RNA interference: the fragile X syndrome connection.
Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.
Carthew
Richard W
RW
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA. r-carthew@northwestern.edu
D000818:Animals; D029721:Drosophila Proteins; D004722:Endoribonucleases / Q000235:genetics / Q000378:metabolism; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D043244:Ribonuclease III; D012261:Ribonucleoproteins / Q000378:metabolism
D029721:Drosophila Proteins; D004722:Endoribonucleases; D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D043244:Ribonuclease III; D012261:Ribonucleoproteins; C467328:FMR1 protein, Drosophila; C497683:FMR1 protein, human; C497684:Fmr1 protein, mouse