[The effect of the synthetic analogue of gonadoliberin on immune response and factors of nonspecific resistance in rats and mice].
Gonadotropin-releasing hormone's synthetic analogue (surfagon) injected intraperitoneally exerted a dose-dependent influence on humoral immune response values in rats and on phagocytic and functional activity of neutrophiles in mice. Castration induced a reliable decrease of the immune response and character. It may be concluded that the surfagon effect is not mediated by steroids.
Bobyntsev
I I
II
Kursk State Medical University, 305041, Kursk, 3 K. Marx St., Russia.
Sever'ianova
L A
LA
Konoplia
A I
AI
Smakhtin
M Iu
MIu
Kriukov
A A
AA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000502:physiology*; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon