title: Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. Taxonomy, fermentation, isolation, structure elucidation and biological activities.
abstract: A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic gram-positive bacteria, whereas gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.
authors.affiliation: Life Science Center Natural Products, Bayer AG, Pharma Research, Wuppertal, P.O.B. 10 17 09, D-42096 Wuppertal, Germany.
authors.forename: Veronika
authors.initials: V
authors.lastname: Hellwig
authors.forename: Torsten
authors.initials: T
authors.lastname: Grothe
authors.forename: Anke
authors.initials: A
authors.lastname: Mayer-Bartschmid
authors.forename: Rainer
authors.initials: R
authors.lastname: Endermann
authors.forename: Frank-Ulrich
authors.initials: FU
authors.lastname: Geschke
authors.forename: Thomas
authors.initials: T
authors.lastname: Henkel
authors.forename: Marc
authors.initials: M
authors.lastname: Stadler
mesh_terms: D000528:Alternaria; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents