[Recent findings on the role of cytokines in the pathogenesis of interstitial pulmonary fibrosis].
Cytokines are important mediators of the pathogenesis of lung fibrosis. The experimental studies carried out in our laboratory have used a murine model of lung silicosis to explore the activity of interleukin-9, -10 and -12. The data presented in this short overview illustrate the pro-fibrotic activity of anti-inflammatory cytokines (IL-10), and the role of type 2 immune polarisation, as illustrated by the paradoxical effect of IL-9 and the activity of IL-12 p40 subunit.
Lison
D
D
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000276:immunology*; D018664:Interleukin-12 / Q000276:immunology*; D053762:Interleukin-12 Subunit p40; D016906:Interleukin-9 / Q000276:immunology*; D051379:Mice; D021122:Protein Subunits / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000276:immunology*
D016207:Cytokines; D053762:Interleukin-12 Subunit p40; D016906:Interleukin-9; D021122:Protein Subunits; D016753:Interleukin-10; D018664:Interleukin-12