[Protective effect of xinxin capsule on learning and memory impairment in mice].
OBJECTIVE
To investigate the effect of Xinxin Capsule on the scopolamine or ethanol induced impairment of learning and memory retention in mice.


METHODS
Step-through and Morris Water-maze methods, wer used to the protective effect of Xinxin Capsule(0.4, 0.8, 1.6 g.kg-1, ig, 16 d) on the scopolamine or ethanol induced impairment of learning and memory retention in mice.


RESULTS
The Capsule(0.8, 1.6 g.kg-1, ig,) can turn over the Scope so as to induce the impairment of learning, and the Capsule((0.4, 0.8, 1.6 g.kg-1, ig) can improve the ethanol induced impairment of memory retention in mice.


CONCLUSIONS
Xinxin Capsule helps regain as well as impair the learning and memory retention in mice.
Du
G Y
GY
Department of Pharmacology, Institute of Chinese Metaria Medica, China Academy of Tranditional Chinese Medicine, Beiiing 100700, China.
Zhao
Y
Y
Cao
C Y
CY
Cui
H F
HF
Wang
X R
XR
Pang
X X
XX
Liu
X F
XF
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal; D011897:Random Allocation; D012153:Retention, Psychology / Q000187:drug effects*; D012601:Scopolamine / Q000037:antagonists & inhibitors
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D000431:Ethanol; D012601:Scopolamine