title: Variation in oral volatile sulphur compound formation.
abstract: It has been suggested that the level of orally produced volatile sulphur compounds (VSCs) can be of use when monitoring oral malodour or in determining patients at risk of periodontal disease in longitudinal studies. It is not known, however, to what extent the level of VSC in mouth air is a stable, individual characteristic over time.
  
  
  OBJECTIVE
  The hypothesis to be tested was that the level of VSC in mouth air is an individual trait that is stable over time.
  
  
  METHODS
  Two groups of dental students participated in the study (n = 30 and n = 11). The amount of available substrate for VSC formation was standardized by rinses with 6 mM aqueous solutions of cysteine (pH 7.2). Part 1 used a Haliineter to measure 'morning breath' and response to cysteine rinses. Part 2 measured response to cysteine rinsing using a gas chromatograph. Repeated measurements provided information concerning the longitudinal intra-individual variations in level of oral VSC formation.
  
  
  RESULTS
  Both groups showed large intra-individual variations in oral VSC. The differences were enhanced by cysteine rinses.
  
  
  CONCLUSIONS
  The hypothesis was not supported. Oral VSC levels cannot be taken as diagnostic criteria in a normal population because of marked intra-individual variations over time.
authors.affiliation: Department of Cariology, Oral Research Laboratory, Faculty of Dentistry, University of Oslo, Norway. alixr@odont.uio.no
authors.forename: Alix
authors.initials: A
authors.lastname: Young
authors.forename: Grazyna
authors.initials: G
authors.lastname: Jonski
authors.forename: Gunnar
authors.initials: G
authors.lastname: Rölla
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D003545:Cysteine / Q000008:administration & dosage / Q000378:metabolism; D004563:Electrochemistry / Q000295:instrumentation; D004867:Equipment Design; D005500:Follow-Up Studies; D006209:Halitosis / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008137:Longitudinal Studies; D009055:Mouth / Q000378:metabolism*; D013457:Sulfur Compounds / Q000032:analysis* / Q000378:metabolism
chemical_list: D013457:Sulfur Compounds; D003545:Cysteine