Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis.
The aim of the present study was to analyze the levels of osteocalcin, deoxypyridinoline (Dpd) and interleukin-1beta as markers of bone metabolism in peri-implant crevicular fluid (PICF) from peri-implantitis patients. PICF was sampled from a total of 34 endosseous titanium implants from 16 patients; nine females (mean age 52.8, range 40-62 years) and seven males (mean age 56.0, range 36-66 years). The implants had been in place for a period of 9-112 months (mean; 35.8 months) since the loading. These sites were categorized as six peri-implantitis, eight peri-implant mucositis and 20 healthy implant. PICF volume from peri-implantitis sites was significantly higher than mucositis and healthy implant sites (P < 0.01). Osteocalcin levels in PICF from mucositis sites were significantly higher than healthy implants (P < 0.05), whereas peri-implantitis sites were not significantly different from either mucositis or healthy implant sites. Dpd could not be detected in any of the samples examined. IL-1beta levels in PICF from peri-implantitis sites were significantly higher than levels from peri-implant mucositis (P < 0.05) and healthy implant sites (P < 0.01). In conclusion, osteocalcin in PICF may reflect increased local bone turnover around implants. Further, IL-1beta should be a useful marker for peri-implant inflammation.
Murata
Masashi
M
Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Services, Niigata, Japan.
Tatsumi
Jun-Ichi
J
Kato
Yumi
Y
Suda
Satoru
S
Nunokawa
Yasuko
Y
Kobayashi
Yukinao
Y
Takeda
Hiroyuki
H
Araki
Hisao
H
Shin
Kitetsu
K
Okuda
Kazuhiro
K
Miyata
Takashi
T
Yoshie
Hiromasa
H
D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000378:metabolism; D000596:Amino Acids / Q000032:analysis*; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000032:analysis*; D010518:Periodontitis / Q000378:metabolism*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013280:Stomatitis / Q000378:metabolism; D013997:Time Factors; D014025:Titanium
D000596:Amino Acids; D015415:Biomarkers; D015921:Dental Implants; D018836:Inflammation Mediators; D007375:Interleukin-1; D015675:Osteocalcin; C036020:deoxypyridinoline; D014025:Titanium