title: [Primary progressive multiple sclerosis].
abstract: Mainly progressive multiple sclerosis (MPMS) is an uncommon clinical form of multiple sclerosis which includes 10 20% of all patients with the disorder. MPMS shows certain clinical characteristics which differentiate it from other forms of progression of the disease. We review the immunological and radiological behaviour of this clinical form, and discuss recent classifications of the disease and new diagnostic criteria. Finally we comment on the few therapeutic options currently available for these patients and their future prospects.
authors.affiliation: Unidad de Neuroinmulogía Clínica. Hospital de la Vall d'Hebron, Barcelona, España.
authors.forename: L
authors.initials: L
authors.lastname: Brieva
authors.forename: J
authors.initials: J
authors.lastname: Río
authors.forename: X
authors.initials: X
authors.lastname: Montalbán
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D020528:Multiple Sclerosis, Chronic Progressive / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D011859:Radiography
chemical_list: D000305:Adrenal Cortex Hormones; D016899:Interferon-beta