title: Willingness to participate in South African HIV vaccine trials--concerns of medical professionals in the Western Cape.
abstract: OBJECTIVE
  To evaluate the willingness of medical doctors working at a tertiary hospital to participate in HIV vaccine trials, their perceptions of patients' willingness to participate, and the major reasons underlying these views.
  
  
  METHODS
  A self-administered, anonymous postal survey conducted in two rounds between May and July 2001.
  
  
  METHODS
  A tertiary care hospital in the Western Cape.
  
  
  METHODS
  All medical doctors listed on the hospital's staff directory.
  
  
  METHODS
  Willingness to participate in, and to recruit patients into, HIV vaccine trials, and the reasons for this.
  
  
  CONCLUSIONS
  Of the 289 individuals surveyed, 80% stated either that they would not be willing to participate in HIV vaccine trials or that they were unsure about their participation. Meanwhile, 37% stated that they would be willing to recruit patients into vaccine trials. The most common concerns with trial participation were the possibility of vaccine-induced infection and the possibility of testing positive for antibodies to HIV. The surprisingly low level of willingness to participate in trials in this sample of medical professionals highlights the importance of preparatory work to overcome substantial barriers to HIV vaccine trial participation.
authors.affiliation: Department of Family Medicine and Primary Care, University of Stellenbosch, Tygerberg.
authors.forename: Keymanthri
authors.initials: K
authors.lastname: Moodley
authors.forename: Jo
authors.initials: J
authors.lastname: Barnes
authors.forename: Estrelita Janse
authors.initials: EJ
authors.lastname: van Rensburg
authors.forename: Landon
authors.initials: L
authors.lastname: Myer
mesh_terms: D016915:AIDS Vaccines / Q000627:therapeutic use*; D000328:Adult; D001291:Attitude of Health Personnel; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010358:Patient Participation / Q000706:statistics & numerical data*; D018579:Patient Selection; D010560:Personnel Selection / Q000706:statistics & numerical data*; D010820:Physicians / Q000706:statistics & numerical data*; D013019:South Africa
chemical_list: D016915:AIDS Vaccines