title: Immunohistochemistry of voltage-gated calcium channel alpha1B subunit in mouse cerebellum.
abstract: Secretion of neurotransmitters is initiated by voltage-gated calcium influx through presynaptic, voltage- gated N-type calcium channels. However, little is known about their cellular distribution in the mouse cerebellum. In the cerebellum, alpha1B immunoreactivity is found mainly on the cell bodies of all Purkinje cells. In addition, the immunoreactivity was detected on a subset of Purkinje cell dendrites, clustered to form a parasagittal array of bands. In the anterior lobe vermis, immunoreactive Purkinje cell dendrites form narrow stripes separated by broad bands of unstained dendrites. Moving caudally through the vermis, these stripes become thicker as a larger fraction of the Purkinje cell dendrites become immunoreactive. This localization study of the alpha1B pore-forming subunits in mouse cerebellum may guide future investigations of the role of calcium channels in neurological pathways.
authors.affiliation: Department of Anatomy, College of Medicine, Konyang University, Nonsan, Chungnam, 320-711, South Korea.
authors.forename: Seung-Hyuk
authors.initials: SH
authors.lastname: Chung
authors.forename: Kyung-Youl
authors.initials: KY
authors.lastname: Lee
authors.forename: Ki-Hyung
authors.initials: KH
authors.lastname: Kim
authors.forename: Chul-Tae
authors.initials: CT
authors.lastname: Kim
authors.forename: Nam-Seob
authors.initials: NS
authors.lastname: Lee
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sawada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Haga
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukui
authors.forename: Man-Hee
authors.initials: MH
authors.lastname: Rhee
authors.forename: Young-Gil
authors.initials: YG
authors.lastname: Jeong
mesh_terms: D000818:Animals; D020864:Calcium Channels, N-Type / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D011689:Purkinje Cells / Q000378:metabolism
chemical_list: D020864:Calcium Channels, N-Type