Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.
Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). The genetic polymorphisms of these two enzymes might individually alter the production, release, reuptake or degradation of 5-HT during the treatment of selective serotonin reuptake inhibitors (SSRIs), leading to the individual differences in the antidepressant effects of SSRIs. The authors investigated whether a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and a TPH gene polymorphism in intron 7 (TPH-A218C) were associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder during a 6-week study with a specific dosage plan. Fifty-four patients completed the study. The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder.
Yoshida
Keizo
K
Department of Psychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. cxw01076@nifty.com
Naito
Shingo
S
Takahashi
Hitoshi
H
Sato
Kazuhiro
K
Ito
Kenichi
K
Kamata
Mitsuhiro
M
Higuchi
Hisashi
H
Shimizu
Tetsuo
T
Itoh
Kunihiko
K
Inoue
Kazuyuki
K
Tezuka
Takehiko
T
Suzuki
Toshio
T
Ohkubo
Tadashi
T
Sugawara
Kazunobu
K
Otani
Koichi
K
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D005260:Female; D016666:Fluvoxamine / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics* / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000494:pharmacology*
D018687:Antidepressive Agents, Second-Generation; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; D016666:Fluvoxamine