Investigations into the immunomodulatory activity of Argyreia speciosa.
The objective of the present study was to investigate the immunomodulatory activity of Argyreia speciosa on cellular and humoral immunity. Oral administration of the ethanolic extract of A. speciosa root (ASEE), at the doses of 50, 100 and 200 mg/kg in mice, dose-dependently potentiated the delayed-type hypersensitivity reaction induced both by sheep red blood cells (SRBC) and oxazolone. It significantly enhanced the production of circulating antibody titre in mice in response to SRBC. ASEE failed to show any effect on macrophage phagocytosis. Chronic administration of ASEE significantly ameliorated the total white blood cell count and also restored the myelosuppressive effects induced by cyclophosphamide. The present investigation reveals that ASEE possesses immunomodulatory activity.
Gokhale
A B
AB
Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai 400 098, India.
Damre
A S
AS
Saraf
M N
MN
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001772:Blood Cell Count; D027722:Convolvulaceae / Q000737:chemistry*; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006967:Hypersensitivity / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D010081:Oxazolone / Q000276:immunology; D010396:Penicillamine / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D012756:Sheep
D000906:Antibodies; D010936:Plant Extracts; D010081:Oxazolone; D003520:Cyclophosphamide; D010396:Penicillamine