Cytokines and T cell homeostasis.
In recent years it has become apparent that the long-term survival of T cells requires continuous contact with external stimuli. At least two types of stimuli, namely self antigens and cytokines, are involved in maintaining T cell viability. As discussed here, the factors controlling T cell survival and turnover in vivo differ considerably from one T cell subset to another.
Sprent
Jonathan
J
Department of Immunology, IMM4, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. jsprent@scripps.edu
Surh
Charles D
CD
D000818:Animals; D002455:Cell Division / Q000276:immunology; D002470:Cell Survival; D016207:Cytokines / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology; D007378:Interleukins / Q000378:metabolism*; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000502:physiology*
D016207:Cytokines; D007378:Interleukins; D011948:Receptors, Antigen, T-Cell