A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?
A 5-year-old child was colonized by an isolate of Escherichia coli that transferred resistance to third-generation cephalosporins and cefoxitin. This resistance phenotype was encoded on a >75-kb plasmid pLRM 22. The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 beta-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group.
Hoyen
Claudia M
CM
Division of Pediatric Infectious Diseases, Department of Pediatrics, Rainbow Babies and Childrens' Hospital, Cleveland, OH 44106, USA.
Hujer
Andrea M
AM
Hujer
Kristine M
KM
Marshall
Steven H
SH
Carias
Lenore
L
Toltzis
Philip
P
Rice
Louis B
LB
Bonomo
Robert A
RA
D001426:Bacterial Proteins; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C048795:AmpC beta-lactamases; D001618:beta-Lactamases