[Levels of autoantibodies to glutamate receptors and immunological blood parameters in patients with epilepsy].
The role of glutamate receptors in the brain spiking activity was evaluated. The electroencephalographic (EEG) spiking activity was monitored and autoreactive antibodies (aAbs) to subunits of glutamate receptors were assessed in the blood serum of epileptic and ischemic stroke patients. We showed that the level of GluR autoantibodies in blood serum of patients correlates to the intensity of the brain paroxysmal activity. These data confirm our previous observations. The level of GluR1 aABs has been proposed as a specific biomarker typical for epilepsy. This approach could be recommended as an additional criterion for diagnostic of nervous diseases such as epilepsy and ischemic stroke.
Bazarova
V G
VG
Institute of Human Brain Brain, Russian Academy of Sciences, 197386 St.-Peterburg.
Granstrem
O K
OK
Dambinova
S A
SA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D021122:Protein Subunits / Q000276:immunology; D018091:Receptors, AMPA / Q000276:immunology; D017470:Receptors, Glutamate / Q000276:immunology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D021122:Protein Subunits; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C120997:NR2A NMDA receptor