title: Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection.
abstract: Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
authors.affiliation: Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.
authors.forename: Michaela
authors.initials: M
authors.lastname: Lucas
authors.forename: Stephan
authors.initials: S
authors.lastname: Gadola
authors.forename: Ute
authors.initials: U
authors.lastname: Meier
authors.forename: Neil T
authors.initials: NT
authors.lastname: Young
authors.forename: Gillian
authors.initials: G
authors.lastname: Harcourt
authors.forename: Anastasios
authors.initials: A
authors.lastname: Karadimitris
authors.forename: Nikki
authors.initials: N
authors.lastname: Coumi
authors.forename: Dave
authors.initials: D
authors.lastname: Brown
authors.forename: Geoff
authors.initials: G
authors.lastname: Dusheiko
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cerundolo
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D006526:Hepatitis C / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D008213:Lymphocyte Activation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D019002:CD56 Antigen; D037181:Lectins, C-Type; D016693:Receptors, Antigen, T-Cell, alpha-beta; D000099192:CD69 Antigens