[Inhibitory effect of paeonol on lipid peroxidational reaction and oxidational decorate of low density lipoprotein].
OBJECTIVE
To observe the effects of paeonol(Pae) on lipid peroxidational reaction and oxidational decorate of low density lipoprotein(LDL).


METHODS
The rat model of hyperlipidaemia was established by feeding high lipid diet with cholesterol for 6 weeks. The contents of malondialdehyde(MDA) and oxidized low density lipoprotein(OX-LDL) were measured by thiobarbituric acid reactive substance(TBA) method and sandwich method of enzyme-linked immunosorbent assay for detection of polyclone antibody. LDL of serum in healthy person was separated by improve precipitate method.


RESULTS
Pae(300, 150 mg.kg-1) could reduce significantly the levels of MDA of serum, aorta and liver; Pae(300 mg.kg-1) decreased obviously the content of OX-LDL of plasma; Pae(1,000, 200, 40 micrograms.ml-1) refrained markedly the course of oxidational decorate of LDL of serum in healthy person.


CONCLUSIONS
Pae could reduce the levels of MDA and OX-LDL in hyperlipidaemia rats, and refrain the oxidational decorates of LDL of serum in healthy person.
Dai
M
M
Anhui College of TCM, Hefei 230031, Anhui, China.
Liu
Q Y
QY
Gu
C G
CG
Zhang
H Y
HY
D000098:Acetophenones / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000098:Acetophenones; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; C013638:paeonol