[WT1-mediated pathway of transcriptional regulation and leukemia].
WT1 gene encodes a zinc finger transcription factor that regulates transcription of its downstream genes. Some of target genes for WT1 are involved in regulating both cell cycle and cellular proliferation and differentiation. However, WT1 itself is regulated by its upstream genes such as NF-kappaB and GATA-1. Thus there exists a pathway of transcriptional regulation mediated by WT1, which controls development of hematopoietic system. Leukemia results from disrupting the homeostasis among hematopoietic proliferation, differentiation and apoptosis, which is often the consequence of an inappropriate expression of transcription factors and subsequent disruption of the normal gene expression pattern. This article reviews the relationship between the WT1-mediated pathway of transcriptional regulation and leukemia.
Duan
Wei-Ming
WM
Jiangsu Institute of Hematology, The First Affiliated Hospital, Suzhou University, Suzhou 215006, China.
Chen
Zi-Xing
ZX
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; D005786:Gene Expression Regulation; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D016328:NF-kappa B / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics; D056524:Retinoblastoma-Binding Protein 7; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D025721:WT1 Proteins / Q000502:physiology*
C493956:CDKN1A protein, human; D002352:Carrier Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; D016328:NF-kappa B; D009687:Nuclear Proteins; C490746:RBBP7 protein, human; D056524:Retinoblastoma-Binding Protein 7; D014157:Transcription Factors; D025721:WT1 Proteins