Cytotoxic ergosterols from Paecilomyces sp. J300.
Seven ergosterol derivatives (1-7) were isolated from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as 3beta,5alpha-dihydroxy-ergosta-7,22-diene (1), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14), 22-diene-3beta, 7alpha-diol (2), 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3beta,7alpha-diol (3), ergosta-4,6,8(14),22-tetraene-3-one (4), ergosterol (5), ergosterol endoperoxide (6), 3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene (7). Compounds 3-7 showed moderate cytotoxicity against five tumor cells.
Kwon
Hak Cheol
HC
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
Zee
Sang Deuk
SD
Cho
Sae Yun
SY
Choi
Sang Un
SU
Lee
Kang Ro
KR
D000818:Animals; D012831:Bombyx; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D010143:Paecilomyces / Q000737:chemistry* / Q000302:isolation & purification; D014407:Tumor Cells, Cultured
D004875:Ergosterol