Acetylcholinesterase inhibitors from the roots of Angelica dahurica.
In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 microM, respectively.
Kim
Dae Keun
DK
College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
Lim
Jong Pil
JP
Yang
Jae Heon
JH
Eom
Dong Ok
DO
Eun
Jae Soon
JS
Leem
Kang Hyun
KH
D000110:Acetylcholinesterase / Q000378:metabolism*; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase