Effects of 1alpha,25(OH)2D3 and its analogs on dendritic cell function.
1alpha,25-Dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)) and non-calcemic vitamin D analogs induce a persistent state of immaturity in dendritic cells both in vitro and in vivo. These effects are transcriptional in nature, involve alterations in surface ligands as well as cytokine synthesis and release, and are dependent upon the presence of the vitamin D receptor. The vitamin D endocrine system could also play a role in altering immune function in normal physiological conditions. Distinct differences exist in lymph node dendritic cells of vitamin D receptor null mutant mice when compared to normal mice.
Griffin
Matthew D
MD
Nephrology Research Unit, Department of Medicine, Mayo Proteomics Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Kumar
Rajiv
R
D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D005260:Female; D008297:Male; D018167:Receptors, Calcitriol / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
D018167:Receptors, Calcitriol; D002117:Calcitriol