title: ClpP of Streptococcus salivarius is a novel member of the dually regulated class of stress response genes in gram-positive bacteria.
abstract: Nucleotide sequence analysis of the Streptococcus salivarius clpP locus revealed potential binding sites for both the CtsR and HrcA repressors. Dual regulation by HrcA and CtsR was demonstrated by using Bacillus subtilis as a heterologous host, and CtsR was shown to bind directly to the clpP promoter sequence. This is the first example of a clpP gene under the control of HrcA.
authors.affiliation: Unité de Biochimie Microbienne, Institut Pasteur, URA 2172 du Centre National de la Recherche Scientifique, 75724 Paris Cedex 15, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chastanet
authors.forename: Tarek
authors.initials: T
authors.lastname: Msadek
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D004268:DNA-Binding Proteins; D049071:Endopeptidase Clp; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000378:metabolism / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D018869:Heat-Shock Response; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism*; D013291:Streptococcus / Q000201:enzymology* / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C118338:CtsR protein, bacteria; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D012097:Repressor Proteins; D012697:Serine Endopeptidases; D049071:Endopeptidase Clp; D000251:Adenosine Triphosphatases