Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment.
A major goal in the area of cancer prevention and treatment is to make rational use of defined molecular targets in order to block carcinogenesis. Studies conducted in experimental animal models for many human cancers, including those of lung, skin, mammary gland, urinary bladder, colon, and pancreas, have demonstrated that carcinogenesis often may be inhibited by the administration of a highly diverse group of biologic and chemical agents. One very promising and well-studied target is cyclooxygenase (COX)-2. Interestingly, a number of cancers appear to overexpress the COX-2 enzyme, which may play several roles in carcinogenesis. Recent clinical studies have demonstrated the effect of COX-2 inhibitors in the treatment of familial adenomatous polyposis, a genetic disorder that increases the risk for developing colorectal cancer. Ongoing clinical trials with COX-2 inhibitors will increase our understanding and may give us profound insights into the general applicability of this new targeted approach for cancer control.
Subongkot
Suphat
S
Department of Pharmacy, Rush-Presbyterian-St.Luke's Medical Center, Rush University, Chicago, Illinois 60612, USA.
Frame
David
D
Leslie
William
W
Drajer
Deborah
D
D000818:Animals; D002986:Clinical Trials as Topic; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008297:Male; D008565:Membrane Proteins; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis; D016896:Treatment Outcome
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases