Ribozyme therapeutics.
Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review discusses the promises and pitfalls of ribozyme technology, with a special emphasis on cancer-related applications, though relevance to skin disease will also be discussed.
Kashani-Sabet
Mohammed
M
Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, UCSF Cancer Center, and Department of Dermatology, University of California San Francisco, San Francisco, California 94115, USA. kashanisabet@orca.ucsf.edu
D000818:Animals; D016503:Drug Delivery Systems; D004345:Drug Industry; D006801:Humans; D016337:RNA, Catalytic / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy
D016337:RNA, Catalytic