[Cytological and molecular changes in the atypical case of accelerated human aging].
A complex research of cells of a patient with unusual form of premature ageing was made. The clinical picture is not typical for any of known forms of hereditary premature aging--progerias. Skin fibroblasts of the patient AG has limited proliferation capacity in vitro. It was shown by fluorescent-immunochemical hybridization (FISH-method), that the level of stable chromosome aberrations in AG blood lymphocytes was characteristic of aged 55-65 years, though as he was only 26 years old. Some characteristic peculiarities, typical for progerias, were found in the reaction of skin fibroblasts of AG to growth factors addition. Some clinical and biochemical peculiarities are results rather, than reasons of the disease. The conclusion is that the premature ageing in this case is a manifestation of Werner's syndrome--one of hereditary forms of accelerated senescence.
Kovina
M V
MV
A. M. Belozersky Institute of Physico-Chemical Biology RAS, Moscow.
Khavinson
V Kh
VKh
Strekalov
D L
DL
Solov'eva
D V
DV
Vorobtsova
I E
IE
Terekhov
S M
SM
Pleskach
N M
NM
Prokof'eva
V V
VV
Spivak
I M
IM
Timonina
G A
GA
Mikhel'son
V M
VM
D000328:Adult; D000375:Aging / Q000473:pathology*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D002455:Cell Division; D003483:Cutis Laxa / Q000175:diagnosis; D003937:Diagnosis, Differential; D005347:Fibroblasts / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000188:drug therapy; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008103:Liver Cirrhosis / Q000517:prevention & control; D008297:Male; D011239:Prednisolone / Q000009:adverse effects; D011371:Progeria / Q000175:diagnosis; D012867:Skin / Q000473:pathology; D014898:Werner Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
D000893:Anti-Inflammatory Agents; D011239:Prednisolone