Nuclear envelope dynamics in oocytes: from germinal vesicle breakdown to mitosis.
We have recently gained new insight into the mechanisms involved in nuclear envelope breakdown, the irreversible step that commits a cell to the M phase. Results from mammalian cell and starfish oocyte studies suggest that mechanical forces of the cytoskeleton, as well as biochemical disassembly of nuclear envelope protein complexes, play important roles in this process.
Lénárt
Péter
P
Gene Expression and Cell Biology/Biophysics Programmes, European Molecular Biology Laboratory, D-69117, Heidelberg, Germany.
Ellenberg
Jan
J
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D005306:Fertilization / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D009865:Oocytes / Q000378:metabolism* / Q000648:ultrastructure