title: The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003.
abstract: The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current knowledge in the Life Sciences. Each protein entry provides an interdisciplinary overview of relevant information by bringing together experimental results, computed features and sometimes even contradictory conclusions. Detailed expertise that goes beyond the scope of SWISS-PROT is made available via direct links to specialised databases. SWISS-PROT provides annotated entries for all species, but concentrates on the annotation of entries from human (the HPI project) and other model organisms to ensure the presence of high quality annotation for representative members of all protein families. Part of the annotation can be transferred to other family members, as is already done for microbes by the High-quality Automated and Manual Annotation of microbial Proteomes (HAMAP) project. Protein families and groups of proteins are regularly reviewed to keep up with current scientific findings. Complementarily, TrEMBL strives to comprise all protein sequences that are not yet represented in SWISS-PROT, by incorporating a perpetually increasing level of mostly automated annotation. Researchers are welcome to contribute their knowledge to the scientific community by submitting relevant findings to SWISS-PROT at swiss-prot@expasy.org.
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. brigitte.boeckmann@isb-sib.ch
authors.forename: Brigitte
authors.initials: B
authors.lastname: Boeckmann
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Blatter
authors.forename: Anne
authors.initials: A
authors.lastname: Estreicher
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gasteiger
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Martin
authors.forename: Karine
authors.initials: K
authors.lastname: Michoud
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Phan
authors.forename: Sandrine
authors.initials: S
authors.lastname: Pilbout
authors.forename: Michel
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000818:Animals; D019843:Archaeal Proteins / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry; D030562:Databases, Protein; D006801:Humans; D016247:Information Storage and Retrieval; D023421:Models, Animal; D010940:Plant Proteins / Q000737:chemistry; D011506:Proteins / Q000737:chemistry* / Q000145:classification; D020543:Proteome / Q000737:chemistry; D040901:Proteomics; D018511:Systems Integration; D009626:Terminology as Topic
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D010940:Plant Proteins; D011506:Proteins; D020543:Proteome