New nitrogen mustards structurally related to (L)-carnitine.
Enantiopure nitrogen mustards which mimic (L)-carnitine framework are prepared by a multi-step synthesis from the (R)-di-tert-butyl malate and their antitumor properties evaluated.
Faissat
Ludovic
L
ENSCM, Laboratoire de Chimie Biomoléculaire, UMR 5032, 8 Rue de l'Ecole Normale, 34296 Montpellier Cédex 05, France.
Martin
Katja
K
Chavis
Claude
C
Montéro
Jean-Louis
JL
Lucas
Marc
M
D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000494:pharmacology; D002331:Carnitine / Q000031:analogs & derivatives*; D006801:Humans; D020128:Inhibitory Concentration 50; D008293:Malates / Q000737:chemistry; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; D008293:Malates; D009588:Nitrogen Mustard Compounds; C030298:malic acid; D002331:Carnitine