[New substituted 4-thioxothiazolidin-2-one derivatives: synthesis and structural study].
Synthesis and physico-chemical properties of some 3-benzyl- and 3-phenacyl-4-thioxo-5-benzylidenethiazolidin-2-one derivatives are described. Fifteen new compounds were synthesized from thiazolidin-2-one by thionation of the 4-carbonyle, alkylation of the 3-N and aldolisation-crotonisation of 5-CH(2) with aromatic aldehydes. Soon, these new compounds will be tested for their bacteriostatic activity.
Chantegrel
J
J
Laboratoire de Chimie-Pharmacie, CNRS UPR 5077, Université Joseph Fourier, Grenoble I, F 38706 La Tronche Cedex, France.
Albuquerque
J C
JC
Guarda
V L
VL
Perrissin
M
M
Lima
M C A
MC
Galdino
S L
SL
Brandão
S S
SS
Thomasson
F
F
Pitta
I R
IR
Luu-Duc
C
C
D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
C471060:4-thioxothiazolidin-2-one; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D013844:Thiazoles