[Cytogenetic aberrations in the cells of liver and spermatogenetic epithelium in senescence accelerated SAMP1 and SAMR1 mice].
It was shown that during ontogenesis, the mice prone to (SAMP1) and resistant against accelerates senescence did not differ substantially in the frequency of cytogenetic aberrations in the hepatocytes and spermatogenic cells (spermatozoa and circular spermatids). These data suggest that in the mice of both lines, the processes of appearance, development, and functioning of complex biological systems, such as liver and testis, take place against the background of high genetic instability. The role of genetic instability in senescence is discussed.
Zakhidov
S T
ST
Biological Faculty and Institute of Mechanics, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia.
Marshak
T L
TL
Uryvaeva
I V
IV
Gopko
A V
AV
Semenova
M L
ML
Delone
G V
GV
Mikhaleva
Ia Iu
IaIu
Makarov
A A
AA
D000367:Age Factors; D019588:Aging, Premature / Q000235:genetics; D000818:Animals; D002869:Chromosome Aberrations; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016296:Mutagenesis; D013087:Spermatids / Q000166:cytology / Q000502:physiology; D013093:Spermatogonia / Q000166:cytology / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology / Q000502:physiology