A comparison of cycle control, efficacy, and side effects among healthy Thai women between two low-dose oral contraceptives containing 20 microg ethinylestradio1/75 microg gestodene (Meliane) and 30 microg ethinylestradio1/75 microg gestodene (Gynera).
The purpose of this study was to compare cycle control, efficacy and side effects of an oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene, with a reference preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene. From the study, it was demonstrated that the two regimens had no difference in cycle control, efficacy, and side effects. The occurrence of spotting and breakthrough bleeding was low and was not different between these two preparations. The most common adverse events in both treatment groups were nausea, vomiting, dizziness, and chloasma. There were no statistically significant change in body weight and blood pressure in both groups at the end of study. It is concluded that both preparations are good cycle control, reliable and low side effects oral contraceptives.
Taneepanichskul
S
S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. surasakta@yahoo.com
Kriengsinyot
R
R
Jaisamrarn
U
U
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003276:Contraceptives, Oral / Q000008:administration & dosage* / Q000009:adverse effects*; D004244:Dizziness / Q000139:chemically induced; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008548:Melanosis / Q000139:chemically induced; D008597:Menstrual Cycle / Q000187:drug effects*; D009325:Nausea / Q000139:chemically induced; D009652:Norpregnenes / Q000008:administration & dosage* / Q000009:adverse effects; D013785:Thailand; D014592:Uterine Hemorrhage; D014839:Vomiting / Q000139:chemically induced
D003276:Contraceptives, Oral; D009652:Norpregnenes; C033273:Gestodene; D004997:Ethinyl Estradiol