The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.
The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
Cotecchia
Susanna
S
Institut de Pharmacologie et Toxicologie, Faculté de Médecine, 1005 Lausanne, Switzerland. susanna.cotecchia@ipharm.unil.ch
Björklöf
Katja
K
Rossier
Olivier
O
Stanasila
Laura
L
Greasley
Peter
P
Fanelli
Francesca
F
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D015398:Signal Transduction
C547716:ADRA1B protein, human; C547717:Adra1b protein, mouse; D000316:Adrenergic alpha-Agonists; D018340:Receptors, Adrenergic, alpha-1; D005947:Glucose