title: Long-term follow-up study of HTLV-I infection in bottle-fed children born to seropositive mothers.
abstract: Human T-lymphotropic virus Type-I (HTLV-I) infects children via mother's milk. Infection of Human T-lymphotropic virus Type-I (HTLV-I) was investigated by long-term follow-up surveys of modified milk-fed children. Our observations of modified milk-fed infants revealed that: 1 of 154 (0.6%) at year 1, 5 of 129 (3.9%) at 1.5 years, and 5 of 108 (4.6%) at year 2 were anti-HTLV-I antibody-positive. No infants or children became newly antibody-positive thereafter. Modified milk feeding could prevent the HTLV-I infection of infants from mothers in many cases, however the infants who had became anti-HTLV-I antibody-positive due to established infection by the age 2 remained positive at age 11-12 with persistent infections. Modified milk-fed infants who had been born from HTLV-I seropositive mothers did not show that they had complete protection from HTLV-I infection, but a low infection rate was seen, showing that modified milk feeding is useful to protect from HTLV-I infection.
authors.affiliation: Wakayama Medical University, Kihoku Hospital, Obstetrics and Gynecology, Myoji 219, Katsuragi, Ito, Japan. SNC76080@nifty.com
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Kakimoto
authors.forename: T
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ekuni
authors.forename: M
authors.initials: M
authors.lastname: Kawa
authors.forename: T
authors.initials: T
authors.lastname: Toyama
mesh_terms: D000818:Animals; D001903:Bottle Feeding; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000276:immunology* / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008892:Milk; D008895:Milk, Human / Q000821:virology; D011247:Pregnancy
chemical_list: D015481:HTLV-I Antibodies