[Effect of treatment with perftoran on the course of experimental uveitis, lipid peroxidation and activity of antioxidant defense enzymes].
Experimental uveitis is characterized by a pronounced lipid peroxidation (LPO) in damaged tissues of eye, which is complicated by reduced activity of the antioxidant enzymes, SOD and catalase. The intensification of LPO was also found in blood serum and hepatic tissue. However, hepatic lipid peroxidation was accompanied by compensatory increase of catalase activity. The activity of antioxidant defence enzymes decreased in blood, whereas catalase was activated in hepatic tissue. The therapeutic effect was accompanied by a decrease of LPO products and increase of activity of the antioxidant enzymes in all tissues. Treatment of uveitis with gentamycin and, especially, perftoran reduced inflammatory events.
Karimova
M Kh
MKh
2nd Tashkent State Medical Institute, Uzbekistan.
Inoiatova
F Kh
FKh
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood / Q000378:metabolism*; D005466:Fluorocarbons / Q000627:therapeutic use*; D005839:Gentamicins / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D015829:Uveitis, Suppurative / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005466:Fluorocarbons; D005839:Gentamicins; C063334:perftoran; D002374:Catalase; D013482:Superoxide Dismutase