Fatigue and depression are associated with poor quality of life in ALS.
Twenty-five ALS subjects filled out five questionnaires: the ALS Functional Rating Scale, Multidimensional Fatigue Inventory, multidimensional McGill Quality of Life, Center of Epidemiologic Study--Depression Scale, and the Epworth Sleepiness Scale. Fatigue, depression, and excessive somnolence are more pronounced in ALS subjects than in normal controls. Both fatigue and depression are associated with poorer quality of life in subjects with ALS, and should be treated aggressively.
Lou
Jau-Shin
JS
Department of Neurology, Oregon Health & Science University, Portland 97201, USA. Louja@ohsu.edu
Reeves
Alexa
A
Benice
Theodore
T
Sexton
Gary
G
D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D003863:Depression / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D003943:Diagnostic Techniques, Neurological; D005221:Fatigue / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009483:Neuropsychological Tests; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires