Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.
The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
Shibuya
Hirotaka
H
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan. shibuya@fupharm.fukuyama-u.ac.jp
Kitamura
Chinami
C
Maehara
Shoji
S
Nagahata
Marie
M
Winarno
Hendig
H
Simanjuntak
Partomuan
P
Kim
Hye-Sook
HS
Wataya
Yusuke
Y
Ohashi
Kazuyoshi
K
D001711:Biotransformation; D002929:Cinchona / Q000737:chemistry / Q000382:microbiology*; D002930:Cinchona Alkaloids / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry / Q000302:isolation & purification; D010087:Oxides / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry / Q000382:microbiology
D002930:Cinchona Alkaloids; D010087:Oxides