Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. Taxonomy, fermentation, isolation, structure elucidation and biological activities.
A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic gram-positive bacteria, whereas gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.
Hellwig
Veronika
V
Life Science Center Natural Products, Bayer AG, Pharma Research, Wuppertal, P.O.B. 10 17 09, D-42096 Wuppertal, Germany.
Grothe
Torsten
T
Mayer-Bartschmid
Anke
A
Endermann
Rainer
R
Geschke
Frank-Ulrich
FU
Henkel
Thomas
T
Stadler
Marc
M
D000528:Alternaria; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents