title: S-18886 Servier.
abstract: S-18886, the active isomer of S-18204, is a thromboxane A2 receptor antagonist with a long duration of action. The compound is under development by Servier for the potential treatment of cardiovascular diseases [269611]. By 2000, a clinical trial had been carried out in patients with coronary artery disease [389458]; advanced clinical trials were ongoing in August 2001 [420310].
authors.affiliation: Irvine Laboratory for Cardiovascular Investigation and Research, Department of Vascular Surgery, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 10th Floor QEQM Wing, St Mary's Hospital, London, W2 1NY, UK. s.kakkos@ic.ac.uk
authors.forename: Stavros K
authors.initials: SK
authors.lastname: Kakkos
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Nicolaides
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D004345:Drug Industry / Q000331:legislation & jurisprudence* / Q000379:methods; D006801:Humans; D009281:Naphthalenes; D011422:Propionates; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D009281:Naphthalenes; D011422:Propionates; D013764:Tetrahydronaphthalenes; C501362:terutroban