title: Chorioamnionitis and brain injury.
abstract: The limited available evidence supports a strong association of chorioamnionitis with neonatal encephalopathy and CP in the term infant. The association of chorioamnionitis with depressed Apgar scores or neonatal seizures and with CP is equivocal in the preterm infant. Different study results may be related to differences in study populations, perhaps specifically to differences in susceptibility by stages of neurologic development as well as differences in gene frequencies associated with inflammation and thrombophilia. We require further understanding of the normal roles of cytokines in brain development, pregnancy, and inflammatory homeostasis before clinical interventions directed at cytokines, their receptors, or the inflammatory process are considered.
authors.affiliation: Eudowood Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University, 600 N. Wolfe St., Park 256, Baltimore, MD 21287-4933, USA. rwilloug@jhmi.edu
authors.forename: Rodney E
authors.initials: RE
authors.lastname: Willoughby
authors.forename: Karin B
authors.initials: KB
authors.lastname: Nelson
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001720:Birth Injuries / Q000382:microbiology*; D001930:Brain Injuries / Q000151:congenital* / Q000382:microbiology*; D002547:Cerebral Palsy / Q000151:congenital* / Q000382:microbiology*; D002821:Chorioamnionitis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000151:congenital* / Q000382:microbiology*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology; D007249:Inflammation; D008403:Mass Screening / Q000379:methods; D011247:Pregnancy; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D000900:Anti-Bacterial Agents