[Value of combined detection of tumor markers for the prediction of small cell and non-small cell lung cancer].
To evaluate the value of detection of 4 tumor markers(CEA, CA125, gastrin, and NSE) for histological types in patients with lung cancer and to improve the predicted efficiency of tumor markers for distinguishing between small cell lung cancer(SCLC) and non-small cell lung cancer (NSCLC), these 4 tumor markers in serum were determined in 51 patients (21 cases with SCLC, 30 cases with NSCLC) with confirmed primary diagnosis of lung cancer of different histology by radioimmunoassay. Linear learning machine method, PRIMA method and KNN method were used to classify SCLC and NSCLC. The levels of gastrin and NSE in SCLC were apparently higher than those of gastrin and NSE in NSCLC, but the levels of CEA and CA125 in SCLC were significantly lower than those in NSCLC. Smoking had an effect on the levels of CEA and CA125, but had little effect on those of gastrin and NSE. The total accuracy of the three methods was over 85% in distinguishing SCLC from NSCLC. So combined detection of the four tumor markers in serum might be useful in the prediction of histological types in patients with lung cancer.
Wu
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Department of Labor Health and Health Toxicology, College of Public Health, Henan Medical University, Zhengzhou 450052, China.
Wu
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Wang
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Qu
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D000230:Adenocarcinoma / Q000097:blood / Q000145:classification; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000145:classification*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000145:classification*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000145:classification; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000145:classification*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D005755:Gastrins; D010751:Phosphopyruvate Hydratase