World Health Organization classification of hematopoietic and lymphoid tissues: implications for dermatology.
The new World Health Organization (WHO) classification of hematopoietic and lymphoid malignancy represents the first worldwide consensus document on the classification of lymphoma/leukemia. Its aim is to supercede all existing classification systems, including the Revised European American Classification (REAL), and the organ-based classification of cutaneous lymphoma proposed in 1997 by the European Organization for Research and Treatment of Cancer (EORTC) cutaneous lymphoma project group. This article compares the REAL, EORTC, and WHO classifications with particular reference to cutaneous lymphoma. It identifies those entities that have been adopted from the EORTC classification, and illustrates important new entities in the category of cytotoxic T-/NK-cell lymphomas that characteristically present in the skin or subcutaneous tissue. However, WHO is not an organ-based classification and some categories (eg follicular B-cell lymphoma and peripheral T-cell lymphoma) include both cutaneous and systemic diseases, and these may have very different prognoses. It is, therefore, important that cancer registries are capable of recording sites of involvement for both B- and T-cell lymphomas so that the incidence and prognosis of cutaneous lymphomas can be established from national data sets in future years.
Russell-Jones
Robin
R
Skin Tumor Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
D019337:Hematologic Neoplasms / Q000145:classification*; D006801:Humans; D008223:Lymphoma / Q000145:classification*; D016393:Lymphoma, B-Cell / Q000145:classification; D016399:Lymphoma, T-Cell / Q000145:classification; D012878:Skin Neoplasms / Q000145:classification*; D014944:World Health Organization