Classifying human cancer by analysis of gene expression.
With the development and application of DNA microarrays, the expression of almost all human genes can now be systematically examined in human malignancies. This can lead to the identification of candidate molecular targets for therapeutic intervention and biomarkers for early detection of these diseases. However, perhaps the most exciting result to come from this research has been the demonstration that patterns of gene expression can distinguish between tumors of different anatomical origin, and define new subgroups of cancer with similar histological appearance, but distinct molecular profiles. Some of these new molecular subclasses of tumor appear to correlate with clinical behavior. If substantiated in larger studies, this might form a basis for stratifying patients so that they receive optimal therapeutic treatment and follow-up.
Hampton
Garret M
GM
Genomics Institute of the Novartis Research Foundation, 10 675 John Jay Hopkins Drive, San Diego, CA 92121, USA. hampton@gnf.org
Frierson
Henry F
HF
D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software; D016896:Treatment Outcome