Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata.
In an effort to identify neuroprotective compounds against excitatory neurotoxins from edible and medicinal mushrooms, dictyoquinazols A (1), B (2), and C (3) have been isolated from the methanolic extract of the mushroom Dictyophora indusiata. On the basis of NMR studies, their structures have been assigned as unique quinazoline compounds, which are very rare in nature. 2 and 3 existed as mixtures of rotamers (2a, 2b and 3a, 3b) inseparable by HPLC because of fast interconversion. The E/Z isomers of these compounds were assigned by comparison of (1)H NMR, (13)C NMR, and NOESY spectra and by (3)J(C,H) coupling constants. Dictyoquinazols protected primary cultured mouse cortical neurons from glutamate- and NMDA-induced excitotoxicities in a dose-dependent manner.
Lee
In-Kyoung
IK
Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Yun
Bong-Sik
BS
Han
Gyoonhee
G
Cho
Duck-Hyun
DH
Kim
Young-Ho
YH
Yoo
Ick-Dong
ID
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D002525:Cerebellar Cortex / Q000166:cytology; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000494:pharmacology; D007723:Korea; D051379:Mice; D015394:Molecular Structure; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D018696:Neuroprotective Agents; D011799:Quinazolines; D014315:Triterpenes; C473161:dictyoquinazol A; C473159:dictyoquinazol B; C473160:dictyoquinazol C; D018698:Glutamic Acid; D016202:N-Methylaspartate