[Lymphocyte reaction and humoral immune response to brain specific protein in children with pathology of the central nervous system].
Blood lymphocyte reaction to brain specific protein (BSP) in vitro and anti-brain antibodies (AB) levels were studied in newborns and infants with perinatal central nervous system (CNS) damages of various severity. A relationship between severity of CNS damages and a lymphocyte reaction to BSP as well as immuno-regulative index (IRI) changes. A combination of high AB to BSP levels with IRI elevation after cells incubation with BSP was found to be a favorable prognostic sign. In contrast, IRI reduction combined with higher AB levels appeared to be an unfavorable one.
Autenshlius
A I
AI
Ivanova
O V
OV
Timofeeva
E P
EP
Kosacheva
A V
AV
Mikhailova
E S
ES
D000917:Antibody Formation; D001921:Brain / Q000276:immunology*; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D002493:Central Nervous System Diseases / Q000097:blood* / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011506:Proteins / Q000276:immunology* / Q000502:physiology
D015704:CD4 Antigens; D016827:CD8 Antigens; D011506:Proteins