An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes.
CD14, a lipopolysaccharide (LPS) receptor, is present on the surface membrane of phagocytic leukocytes; it is also present in a soluble form in serum. Recently published results confer to this molecule novel functions that are linked to T-cell activation and to apoptosis. We report here that we have defined and characterized a novel lymphocyte population in human peripheral blood, a population that expresses an intracellular antigen detectable with MO2, a monoclonal antibody directed against the human CD14 molecule. This population is composed primarily of CD8-positive T-cells. We found surprisingly that this novel MO2-positive population of lymphocytes was greatly enhanced in asymptomatic, untreated HIV-positive individuals.
Tartakovsky
Boris
B
Research Unit, Clinical Immunology and AIDS Center, Tel Aviv Sourasky Medical Center, 6 Weizmann Str., 64239, Tel Aviv, Israel. b.tartakovsky@medscape.com
Fried
Mordechai
M
Bleiberg
Margalit
M
Turner
Dan
D
Hoffman
Michael
M
Yust
Israel
I
D000911:Antibodies, Monoclonal / Q000378:metabolism*; D000941:Antigens / Q000378:metabolism*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000941:Antigens; D018950:Lipopolysaccharide Receptors