[Status of microcirculation and cardiodynamics in ischemic heart disease patients with decreased left ventricular fraction and their response to carvedilol].
OBJECTIVE
Assessment of microcirculation in IHD patients at preclinical stage or in those with initial symptoms of cardiac failure, clarification of relationship between parameters of microcirculation and cardiodynamics.


METHODS
A blind cross-over trial was made to compare skin microcirculation and cardiodynamic parameters in response to a short carvedilol course and beta-blocker anaprilin in 40 patients with ischemic heart disease with angina of effort (NYHA class I-IV, ejection fraction under 45%).


RESULTS
IHD with initial symptoms of cardiac failure had a congestion-spastic type of microcirculation defect. Microcirculatory picture and cardiodynamics were related.


CONCLUSIONS
Compared to anaprilin therapy, treatment with carvedilol enhanced capillary blood flow and improved cardiodynamics.
Vasil'ev
A P
AP
Strel'tsova
N N
NN
Gorbunova
T Iu
TIu
D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D018592:Cross-Over Studies; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008833:Microcirculation; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D011412:Propanolamines / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply; D016277:Ventricular Function, Left
D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D011433:Propranolol