title: SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
abstract: We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expenditure. In white adipose tissue, lack of TIF2 decreases PPARgamma activity and reduces fat accumulation, whereas in brown adipose tissue it facilitates the interaction between SRC-1 and PGC-1alpha, which induces PGC-1alpha's thermogenic activity. Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Picard
authors.forename: Martine
authors.initials: M
authors.lastname: Géhin
authors.forename: Jean- Sébastien
authors.initials: J
authors.lastname: Annicotte
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rocchi
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Champy
authors.forename: Bert W
authors.initials: BW
authors.lastname: O'Malley
authors.forename: Pierre
authors.initials: P
authors.lastname: Chambon
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000648:ultrastructure; D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D001835:Body Weight; D002478:Cells, Cultured; D004734:Energy Metabolism / Q000235:genetics*; D051548:Histone Acetyltransferases; D050356:Lipid Metabolism; D008066:Lipolysis / Q000235:genetics; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D056920:Nuclear Receptor Coactivator 1; D051958:Nuclear Receptor Coactivator 2; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*; D010101:Oxygen Consumption / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D022722:Thermogenesis / Q000235:genetics; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism
chemical_list: C498002:Ncoa2 protein, mouse; D051958:Nuclear Receptor Coactivator 2; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D051548:Histone Acetyltransferases; C538861:Ncoa1 protein, mouse; D056920:Nuclear Receptor Coactivator 1