[The pathophysiological role of smooth muscle cells in bronchial inflammation].
Airway smooth muscle cells (SMC) have been implicated in the pathophysiology of bronchial inflammation. SMC can be considered a target of the inflammatory reaction. This cell-type is capable of contraction, proliferation and mediator synthesis in response to various stimuli, in particular those associated with the inflammatory reaction. SMC can also be considered as an inflammatory cell-type. Cytokines and adhesion molecules released by SMC have an autocrine action and paracrine action on other cell-types, particularly those involved in inflammation, inducing chemotactism and cell adhesion. This interaction allows SMC to directly act on cells such as the T-lymphocyte, the eosinophil and the mast cell. SMC could therefore be a potential target of anti-inflammatory treatment.
Berger
P
P
Laboratoire de Physiologie Cellulaire Respiratoire, INSERM E9937, Université Victor Ségalen Bordeaux 2, Bordeaux, France. patrick.berger@lpcr.u-bordeaux2.fr
Marthan
R
R
Tunon de Lara
J-M
JM
D001249:Asthma / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000494:pharmacology; D002455:Cell Division; D016207:Cytokines / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009130:Muscle, Smooth / Q000473:pathology*; D032389:Myocytes, Smooth Muscle / Q000473:pathology*
D015815:Cell Adhesion Molecules; D016207:Cytokines