Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia.
Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect of a pharmacological endogenous bone marrow mobilization in the course of cerebral ischemia and open a new direction for cellular therapy strategy in stroke.
Six
Isabelle
I
EA1046-Laboratoire de Pharmacologie, Faculté de Médecine, Université de Lille 2, France.
Gasan
Gaëlle
G
Mura
Emmanuelle
E
Bordet
Régis
R
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015996:Survival Rate; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor