title: Chiral separation of 2,3-allenoic acid by capillary zone electrophoresis using cyclodextrin derivatives.
abstract: In this paper, five of six samples of 2,3-allenoic acid enantiomers were separated by capillary zone electrophoresis (CZE) using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) as chiral selectors. Using HP-beta-CD for chiral separation, three of the six enantiomers were separated. Five experimental conditions including HP-beta-CD concentration, pH, buffer concentration, temperature, and running voltage were investigated for their influence on separation and migration using enantiomers of 2-methyl-4-phenyl-2,3-butadienoic acid (A) and 2-(n-propyl)-4-phenyl-2,3-butadienoic acid (B) as samples. Good separation results were observed when [HP-beta-CD] = 3-12 mmol/L and pH = 7-9 for samples A and B. The temperature range of 15-25 degrees C can be selected for convenience. According to the chiral separation results, HP-beta-CD and HP-gamma-CD should be valuable selectors to separate 2,3-allenoic acids and HP-gamma-CD was suggested to separate the 2,3-allenoic acid samples with a group at 4-position bulkier than phenyl.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. xuxu@pub.sioc.ac.cn
authors.forename: Xu
authors.initials: X
authors.lastname: Xu
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Bao
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Dong
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
authors.forename: Zhan-Qian
authors.initials: ZQ
authors.lastname: Yu
authors.forename: Sheng-Ming
authors.initials: SM
authors.lastname: Ma