[Recovery effect of cardiomyopeptidin fractions and fraction addition on cardiac muscle cells in rats damaged by adriamycin].
OBJECTIVE
To investigate the recovery effect of cardiomyopeptidin fractions and fraction addition on the cardiac muscle cells in rats damaged by adriamycin.


METHODS
Observing the activity of the succinic dehydrogenase which is at mitochondrion in the cells damaged by adriamycin with MTT.


RESULTS
Five fractions have all promoted the activating effect of the enzyme, the action of PI being higher than the others. Fraction addition has also promoted the activating effect of the enzyme, but without additive effect.


CONCLUSIONS
The recovery effect of cardimyopeptidin depends on the interplay among the fractions.
Yang
L P
LP
Department of Molecular Biology, Infectious Disease Center, 458th Hospital of PLA, Guangzhou 510602, Guangdong, China.
Kong
X P
XP
Li
R B
RB
Zeng
P L
PL
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004317:Doxorubicin / Q000037:antagonists & inhibitors; D008419:Materia Medica / Q000494:pharmacology*; D032383:Myocytes, Cardiac / Q000737:chemistry* / Q000201:enzymology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013552:Swine
D008419:Materia Medica; D010455:Peptides; C470986:cardiomyopeptidin; D004317:Doxorubicin; D013385:Succinate Dehydrogenase