title: Fungichromin: a substance from Streptomyces padanus with inhibitory effects on Rhizoctonia solani.
abstract: Streptomyces padanus strain PMS-702 is an antagonist of Rhizoctonia solani AG-4, the causal agent of damping-off of cabbage. Treatment of cabbage seeds with the culture filtrate of S. padanus strain PMS-702 was effective in reducing the incidence of damping-off of cabbage. The major active ingredient from the culture filtrate of S. padanus strain PMS-702 was purified by silica gel column chromatography and identified as the polyene macrolide, fungichromin, by NMR and mass spectral data. Bioassay studies showed that fungichromin had a strong antifungal activity against R. solani AG-4, and its minimum inhibitory concentration (over 90% inhibition) was found to be 72 microg/mL. This is the first report of fungichromin from S. padanus as an active ingredient for the control of Rhizoctonia damping-off of cabbage.
authors.affiliation: Department of Plant Pathology, National Chung-Hsing University, Taichung, 402, Taiwan.
authors.forename: Hsin-Der
authors.initials: HD
authors.lastname: Shih
authors.forename: Yung-Chuan
authors.initials: YC
authors.lastname: Liu
authors.forename: Fen-Lin
authors.initials: FL
authors.lastname: Hsu
authors.forename: Vanisree
authors.initials: V
authors.lastname: Mulabagal
authors.forename: Rajasekhar
authors.initials: R
authors.lastname: Dodda
authors.forename: Jenn-Wen
authors.initials: JW
authors.lastname: Huang
mesh_terms: D001937:Brassica / Q000382:microbiology; D005659:Fungicides, Industrial / Q000494:pharmacology*; D018942:Macrolides; D015394:Molecular Structure; D011090:Polyenes / Q000032:analysis* / Q000302:isolation & purification / Q000493:pharmacokinetics; D012232:Rhizoctonia / Q000187:drug effects*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D005659:Fungicides, Industrial; D018942:Macrolides; D011090:Polyenes; C011827:fungichromin