title: Current Insights in Whipple's Disease.
abstract: Therapy for Whipple's disease should be continued for a minimum of 1 year, and the regimen should include an agent or agents that achieve acceptable concentrations in the central nervous system, given the likelihood of recurrence at this site. Clinical follow-up of proven cases of Whipple's disease should be conducted for a minimum of 10 years after discontinuation of therapy, given the potential for late relapses. Polymerase chain reaction analysis is preferred rather than endoscopy when evaluating for disease recurrence.
authors.affiliation: Department of Internal Medicine, Eastern Virginia Medical School, Hofheimer Hall, 825 Fairfax Avenue, Norfolk, VA 23507-1912, USA. Flemmemc@evms.edu
authors.forename: Mark C.
authors.initials: MC
authors.lastname: Flemmer
authors.forename: Ronald W.
authors.initials: RW
authors.lastname: Flenner