title: Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system.
abstract: Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of remyelination in a demyelinating disease model, while intrathecal IgM synthesis was shown to predict a more worse disease course in a human demyelinating disease, multiple sclerosis. Molecular mechanisms for either of these IgM functions remain to be studied. Here we report that a recently-found Fc receptor for IgM, namely Fcalpha/muR, is expressed in oligodendrocytes, their precursor cells, and myelin. These expressions were confirmed by immunocytochemistry of cultured cells, Western blot analysis of myelin fractions, and also by immunohistochemistry of mouse forebrains at different ages. Our findings suggest a possible direct interaction between IgM and Fcalpha/muR expressed in oligodendrocytes and myelin.
authors.affiliation: Glial Cell Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Japan. nakaharajin@anet.ne.jp
authors.forename: Jin
authors.initials: J
authors.lastname: Nakahara
authors.forename: Chika
authors.initials: C
authors.lastname: Seiwa
authors.forename: Akira
authors.initials: A
authors.lastname: Shibuya
authors.forename: Sadakazu
authors.initials: S
authors.lastname: Aiso
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Asou
mesh_terms: D000375:Aging; D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD / Q000235:genetics; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000276:immunology*; D002478:Cells, Cultured; D002493:Central Nervous System Diseases / Q000276:immunology; D004622:Embryo, Mammalian; D005314:Embryonic and Fetal Development; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000276:immunology* / Q000648:ultrastructure; D009836:Oligodendroglia / Q000166:cytology / Q000276:immunology; D016133:Polymerase Chain Reaction / Q000379:methods; D011961:Receptors, Fc / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology / Q000276:immunology
chemical_list: D015703:Antigens, CD; C036832:Fc(alpha) receptor; D007075:Immunoglobulin M; D011961:Receptors, Fc