An antiplasmodial lignan from Euterpe precatoria.
As a part of a study on new antiplasmodial natural products, a new 8-5' linked lignan dehydrodiconiferyl dibenzoate (2) and p-hydroxybenzoic acid (1) were isolated from the roots of the palm Euterpe precatoria. In contrast to compound 1, compound 2 showed a moderate antiplasmodial activity.
Jensen
Janne Funder
JF
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Kvist
Lars Peter
LP
Christensen
Søren Brøgger
SB
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010568:Peru; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D062385:Hydroxybenzoates; D017705:Lignans; C473437:dehydrodiconiferyl dibenzoate