title: Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo.
abstract: The cardiovascular consequences of eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-specific intake were evaluated in vivo in a hyperinsulinemia (HI) model induced by dietary fructose intake. Wistar rats were fed a diet containing (or not for control) either EPA or DHA. The rise in blood pressure (BP), heart rate, and ECG were continuously monitored using an intra-abdominal telemetry system. The myocardial phospholipid fatty acid profile was significantly affected by DHA intake but less by EPA intake. The data indicated a reduced rise in BP in both DHA and EPA HI groups compared with controls. This result was confirmed by tail-cuff measurement after 5 wk [133.3 +/- 1.67 and 142.5 +/- 1.12 mmHg in n-3 polyunsaturated fatty acid (PUFA) and control groups, respectively], whereas n-3 PUFA did not affect BP in non-HI rats (116.3 +/- 3.33 mmHg). The heart rate was lower in the HI DHA group than in the other two dietary HI groups. Moreover, DHA induced a significantly shorter QT interval. It is concluded that the cardioactive component of fish oils is DHA through a mechanism that may involve the cardiac adrenergic system.
authors.affiliation: Lipides Membranaires et Fonctions Cardiovasculaires, Institut National de la Recherche Agronomique-UR1154, Faculté de Pharmacie, Université Paris-Sud, 5 rue Jean Baptiste Clément, 92290 Châtenay-Malabry Cedex, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Rousseau
authors.forename: Cécile
authors.initials: C
authors.lastname: Héliès-Toussaint
authors.forename: Daniel
authors.initials: D
authors.lastname: Moreau
authors.forename: Daniel
authors.initials: D
authors.lastname: Raederstorff
authors.forename: Alain
authors.initials: A
authors.lastname: Grynberg
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000097:blood / Q000494:pharmacology; D015118:Eicosapentaenoic Acid; D004562:Electrocardiography; D005227:Fatty Acids / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000494:pharmacology; D005632:Fructose; D006331:Heart Diseases / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006946:Hyperinsulinism / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D005632:Fructose; D015118:Eicosapentaenoic Acid