title: [Effects of curcumin on proliferation and apoptosis in human hepatic cells].
abstract: OBJECTIVE
  To investigate the effect of curcumin on the proliferation, cell cycle distribution and apoptosis of hepatocarcinoma cell line QGY.
  
  
  METHODS
  The MTT method was used to assay the biologic activities of curcumin in different times and different doses. The cell cycle distribution was detected by flow cytometic analysis. The cell ultrastructure was observed by electronic microscopy.
  
  
  RESULTS
  Curcumin could inhibit effectively QGY in a dose- and time- dependent manner. IC(50) of curcumin to QGY was 49.50 micromol/L in 72 hours. The cell growth was arrested at S stage. Curcumin could lead to the degeneration, necrosis, and apoptosis.
  
  
  CONCLUSIONS
  Curcumin can interrupt the cell cycle and has a role in cytotoxicity, antiproliferation and inducing apoptosis of QGY.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of Chongqing University of Medical Sciences, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Che
authors.forename: Weixue
authors.initials: W
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D000970:Antineoplastic Agents; D003474:Curcumin