[Effectiveness of virazol, realdiron and interferon inductors in experimental Omsk hemorrhagic fever].
Efficacy of drug therapy of Omsk hemorrhagic fever (OHF) was tested experimentally using cell culture and laboratory animals infected with the OHF virus strain Ondatra. Screening tests showed that high concentrations of Virazol or interferon inducers Larifan and Rifastin caused moderately pronounced suppression of virus reproduction in cell culture. Realdiron was found to be a high-efficacy preparation causing complete inhibition of virus reproduction in cell. Larifan demonstrated the highest antiviral efficacy against OHF virus in experiments with laboratory animals. This drug prevented the death of 65% infected mice and significantly decreased infection process severity in rabbits.
Loginova
S Ia
SIa
Efanova
T N
TN
Koval'chuk
A V
AV
Faldina
V N
VN
Androshchuk
I A
IA
Pistsov
M N
MN
Borisevich
S V
SV
Kopylova
N K
NK
Pashchenko
Iu I
IuI
Khamitov
P A
PA
Maksimov
V A
VA
Vasil'ev
N T
NT
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D018929:Cell Culture Techniques; D004195:Disease Models, Animal; D018450:Disease Progression; D004669:Encephalitis Viruses, Tick-Borne; D006481:Hemorrhagic Fever, Omsk / Q000188:drug therapy* / Q000473:pathology; D007369:Interferon Inducers / Q000627:therapeutic use*; D007370:Interferon Type I / Q000627:therapeutic use*; D051379:Mice; D009930:Organic Chemicals; D011817:Rabbits; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007369:Interferon Inducers; D007370:Interferon Type I; D009930:Organic Chemicals; D011994:Recombinant Proteins; C066530:larifan; D012254:Ribavirin