Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes.
A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti-Gvh IgA response had an adverse outcome.
Cauci
Sabina
S
Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Italy. scauci@mail.dstb.uniud.it
Thorsen
Poul
P
Schendel
Diana E
DE
Bremmelgaard
Annie
A
Quadrifoglio
Franco
F
Guaschino
Secondo
S
D000328:Adult; D000942:Antigens, Bacterial / Q000032:analysis*; D004150:Dipeptidases / Q000032:analysis; D005260:Female; D006194:Gardnerella vaginalis / Q000737:chemistry / Q000201:enzymology / Q000276:immunology / Q000302:isolation & purification*; D006460:Hemolysin Proteins / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D009439:Neuraminidase / Q000032:analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000382:microbiology*; D011256:Pregnancy Outcome; D016585:Vaginosis, Bacterial / Q000382:microbiology*
D000942:Antigens, Bacterial; D006460:Hemolysin Proteins; D007070:Immunoglobulin A; D009439:Neuraminidase; D004150:Dipeptidases; C022449:proline dipeptidase