title: [Effect of manganese on the ratio of micronucleus cells in mice marrow].
abstract: The ratio of micronucleus in the bone marrow cell of mice induced by manganese (Mn2+, MnCl2) through intraperitoneal injection at doses of 0, 25, 50 and 100 mg/kg respectively was investigated. The number of micronucleus cells per 1000 polychromatic erythrocyte (PCE) from breast bone marrow was counted. The results showed that micronucleus ratio in bone marrow cells were 12.0 and 16.4 per 1000 in the medium and high dosage groups, which were higher than that of control (P < 0.01). There is no distinct difference between the low dosage group and the control group (P > 0.05), but show a rising trend with the dosage of Mn2+. It indicated that the higher the dose of MnCl2, the stronger the toxic effect to the micronucleus in bone marrow cells. MnCl2 is considered having mutation to chromosome and potential heredity toxicity.
authors.affiliation: Department of Preventive Medicine, Capital University of Medical Sciences, Beijing 100054, China.
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Chu
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000648:ultrastructure*; D005260:Female; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D051379:Mice; D015162:Micronucleus Tests; D009154:Mutation
chemical_list: D008345:Manganese