Synthesis and in vitro antimicrobial evaluation of 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles.
The increasing clinical importance of drug-resistant pathogens has lent additional urgency to antimicrobial research. Various 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles (4a-6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5-1 microg/mL and moderate effects against Staphylococcus aureus.
Shafiee
Abbas
A
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Sayadi
Abolfazl
A
Roozbahani
Marjan Hosseini
MH
Foroumadi
Alireza
A
Kamal
Fatemeh
F
D001412:Bacillus subtilis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D009593:Nitroimidazoles