Notch, a unifying target in T-cell acute lymphoblastic leukemia?
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor kappaB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
Screpanti
Isabella
I
Department of Experimental Medicine and Pathology and Istituto Pasteur-Fondazione Cenci-Bolognetti Foundation, University La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy. isabella.screpanti@uniroma1.it
Bellavia
Diana
D
Campese
Antonio F
AF
Frati
Luigi
L
Gulino
Alberto
A
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics* / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D051881:Receptor, Notch1; D000071656:Receptor, Notch3; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D051881:Receptor, Notch1; D000071656:Receptor, Notch3; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D014157:Transcription Factors; C497761:NOTCH1 protein, human; C499374:NOTCH3 protein, human; C407909:TCF3 protein, human