Anti-allergic agents from natural sources (4): anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae).
Two new phloroglucinol derivatives, mallotophilippen A (1). and B (2). were isolated from the fruits of Mallotus philippensis. These compounds were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)-2H-chromen-8-yl]-2-methyl-butan-1-one and 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-2-methyl-butan-1-one, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma). Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects.
Daikonya
Akihiro
A
College of Pharmacy, Nihon University, Chiba, Japan. daikonya@pha.nihon-u.ac.jp
Katsuki
Shigeki
S
Wu
Jin-Bin
JB
Kitanaka
Susumu
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D006636:Histamine Release / Q000187:drug effects; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000378:metabolism; D008297:Male; D036461:Mallotus Plant / Q000737:chemistry*; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D014158:Transcription, Genetic / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D018926:Anti-Allergic Agents; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014315:Triterpenes; C474052:mallotophilippen A; C474053:mallotophilippen B; D009569:Nitric Oxide; D007371:Interferon-gamma; D019001:Nitric Oxide Synthase