[99mTc-ECD SPECT CBF-quantification and its clinical significance].
OBJECTIVE
To establish a quantitative method of non-blood withdrawn with 99mTc-ECD SPECT for measuring cerebral blood flow (CBF).


METHODS
Combining three compartment models and technology of the best parameters by computer with 99mTc-ECD SPECT to quantitate CBF and regional cerebral blood flow (rCBF) in control group and patient group.


RESULTS
The CBFs of the control group (8 cases) and the patient group (16 cases) were (57.16 +/- 4.21) ml.min-1/100 g and (38.80 +/- 8.21) ml.min-1/100 g, respectively. The CBF and rCBF were significantly lower in patient group than those in control group (P < 0.05).


CONCLUSIONS
The method is simple and more convenient for quantification of CBF in patients with brain disorders, and it may increase the diagnostic sensitivity and the accuracy of focus location. It is suggested that the method is accurate and reliable.
Deng
H Y
HY
Department of Nuclear Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Pan
A Y
AY
Shi
G Z
GZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*
D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine