[Evaluation of hypoxic state in experimental animals induced by Yersinia pestis antigens].
Some characteristics of purine metabolism in experimental animals (white mice, clawed jirds and guinea pigs), injected intraperitoneally with Y. pestis "murine" toxin and capsular antigen (Fraction 1), were studied. Under the influence of sublethal doses of these antigens increased levels of guanine and xanthine in blood were noted. Changes in the content of xanthine oxidase in cells were insignificant. In white mice and clawed jirds the activity of succinate dehydrogenase decreased under the action of "murine" toxin and increased after the injection of Fraction 1.
Kagramanov
V S
VS
Research Institute for Plague Control, Rostov-on-Don, Russia.
Aseeva
L E
LE
Goncharov
E K
EK
D000818:Animals; D000942:Antigens, Bacterial; D016667:Bacterial Capsules; D004195:Disease Models, Animal; D005849:Gerbillinae; D006147:Guanine / Q000097:blood; D006168:Guinea Pigs; D000860:Hypoxia / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000378:metabolism; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D019820:Xanthine / Q000097:blood; D014969:Xanthine Oxidase / Q000378:metabolism; D015010:Yersinia pestis
D000942:Antigens, Bacterial; D019820:Xanthine; D006147:Guanine; D014969:Xanthine Oxidase; D013385:Succinate Dehydrogenase