title: Autologous bone-marrow stem-cell transplantation for myocardial regeneration.
abstract: Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5x10(6) autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3-9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium. See Commentary page 11
authors.affiliation: Department of Cardiac Surgery, University of Rostock, 18057, Rostock, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Stamm
authors.forename: Bernd
authors.initials: B
authors.lastname: Westphal
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Kleine
authors.forename: Michael
authors.initials: M
authors.lastname: Petzsch
authors.forename: Christian
authors.initials: C
authors.lastname: Kittner
authors.forename: Heiko
authors.initials: H
authors.lastname: Klinge
authors.forename: Carl
authors.initials: C
authors.lastname: Schümichen
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: Mathias
authors.initials: M
authors.lastname: Freund
authors.forename: Gustav
authors.initials: G
authors.lastname: Steinhoff
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002317:Cardiovascular Agents / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy / Q000628:therapy*
chemical_list: D002317:Cardiovascular Agents