Antibodies to oxidised low-density lipoproteins and cardiolipin in pre-eclampsia and eclampsia.
The objective of this study was to test the hypothesis that autoantibodies to phospholipids and to oxidised low-density lipoprotein (ox-LDL) are increased in pre-eclamptic and eclamptic women compared with normal pregnancy. Serum concentrations of autoantibodies to ox-LDL and to cardiolipin were measured in 21 non-pregnant controls, 29 pregnant controls, 21 pre-eclamptic and six eclamptic women. Concentrations of IgG antibodies to ox-LDL and to cardiolipin were not significantly different in women with eclampsia as compared with the non-pregnant controls, pregnant controls and pre-eclampsia. Concentrations of IgM antibodies to cardiolipin were significantly lower in women with pre-eclampsia compared with non-pregnant controls and eclampsia. All three pregnant states differ markedly from the non-pregnant controls, of whom only 5% (1 of 21) had "high positive" IgG antibodies. These results suggest that ACAs rise as a result of the pregnant state rather than as a result of preeclampsia or eclampsia. According to these results, there is no evidence of increased production of serum autoantibodies against modified LDL in African women with pre-eclampsia, which may reflect reduced lipid peroxidation involving lipoproteins or no link at all. In addition, IgG and IgM anticardiolipin antibodies have no diagnostic value in preeclampsia and eclampsia.
Bowen
R S
RS
Department of Physiology, University of Natal Medical School, Durban, South Africa.
Moodley
J
J
Dutton
M F
MF
Fickl
H
H
D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000150:complications; D015415:Biomarkers; D002308:Cardiolipins / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D004461:Eclampsia / Q000175:diagnosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008077:Lipoproteins, LDL / Q000276:immunology*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D011247:Pregnancy
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D002308:Cardiolipins; D007136:Immunoglobulins; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein