Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24).
Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.
Dal Cin
Paola
P
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. pdalcin@partners.org
Quade
Bradley J
BJ
Neskey
David M
DM
Kleinman
Michael S
MS
Weremowicz
Stanislawa
S
Morton
Cynthia C
CC
D000328:Adult; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics; D018231:Leiomyomatosis / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics; D014594:Uterine Neoplasms / Q000473:pathology; D019043:Vascular Neoplasms / Q000235:genetics / Q000556:secondary