Border-cell migration: the race is on.
The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.
Montell
Denise J
DJ
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA. dmontell@jhmi.edu
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology*; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D010053:Ovary / Q000166:cytology*; D015398:Signal Transduction / Q000502:physiology