title: Photoreaction generating active oxygens of In(3+)-tetrakis(4-methylpyridyl)-porphine in the presence of albumins.
abstract: The complex formation of In(3+)-tetrakis(4-N-methylpyridyl)-porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In(3+) through the -S(-) group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.
authors.affiliation: Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan. mifune@pharm.okayama-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Mifune
authors.forename: Hatsuki
authors.initials: H
authors.lastname: Asahara
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Hinokiyama
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Akizawa
authors.forename: Akimasa
authors.initials: A
authors.lastname: Iwado
authors.forename: Noriko
authors.initials: N
authors.lastname: Motohashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
mesh_terms: D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D012709:Serum Albumin / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013481:Superoxides / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: C474098:In(III)-tetrakis(4-methylpyridyl)-porphine; D008665:Metalloporphyrins; D012709:Serum Albumin; D013481:Superoxides; D010100:Oxygen