title: Persistence of ictal activity after functional hemispherectomy in Rasmussen syndrome.
abstract: A 15-year-old girl with a 3-year history of Rasmussen syndrome (RS) underwent left functional hemispherectomy by central disconnection. Clinical seizures then ceased. Five months postoperatively, ictal EEG discharges were associated with focal hyperperfusion on SPECT within the disconnected hypoperfused left hemisphere, suggesting that the basic mechanisms of RS may continue, only to remit later. EEG and SPECT may complement studies of these in seizure-free surgically treated patients in whom clinical follow-up may be unrevealing.
authors.affiliation: Service de Neurologie, Hôpital Pasteur, Nice, France. piertho@wanadoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Thomas
authors.forename: Benjamin
authors.initials: B
authors.lastname: Zifkin
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ghetâu
authors.forename: Olivier
authors.initials: O
authors.lastname: Delalande
mesh_terms: D000293:Adolescent; D003337:Corpus Callosum / Q000601:surgery; D018450:Disease Progression; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D020712:Fornix, Brain / Q000601:surgery; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D006423:Hemianopsia / Q000209:etiology; D038421:Hemispherectomy / Q000009:adverse effects; D006801:Humans; D007806:Language Disorders / Q000209:etiology; D008279:Magnetic Resonance Imaging; D010291:Paresis / Q000209:etiology; D012074:Remission Induction; D012640:Seizures / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D013788:Thalamus / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed