Gabapentin in late-onset poststroke seizures.
Stroke is a frequent cause of epileptic seizures (ES) in adults. The authors evaluated the long-term efficacy and tolerability of gabapentin (900 to 1,800 mg/day) in 71 patients with a first poststroke late ES during a mean follow-up time of 30 months. ES recurred in 18.3% of the patients and side effects were noted in 27 cases (38%), but only two (2.8%) required discontinuation or early withdrawal. Gabapentin monotherapy was useful and safe for late poststroke ES.
Alvarez-Sabín
J
J
Cerebrovascular Unit, Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain. alsa@hg.vhebron.es
Montaner
J
J
Padró
L
L
Molina
C A
CA
Rovira
R
R
Codina
A
A
Quintana
M
M
D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology*; D020521:Stroke / Q000150:complications*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin