title: [New substituted 4-thioxothiazolidin-2-one derivatives: synthesis and structural study].
abstract: Synthesis and physico-chemical properties of some 3-benzyl- and 3-phenacyl-4-thioxo-5-benzylidenethiazolidin-2-one derivatives are described. Fifteen new compounds were synthesized from thiazolidin-2-one by thionation of the 4-carbonyle, alkylation of the 3-N and aldolisation-crotonisation of 5-CH(2) with aromatic aldehydes. Soon, these new compounds will be tested for their bacteriostatic activity.
authors.affiliation: Laboratoire de Chimie-Pharmacie, CNRS UPR 5077, Université Joseph Fourier, Grenoble I, F 38706 La Tronche Cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Chantegrel
authors.forename: J C
authors.initials: JC
authors.lastname: Albuquerque
authors.forename: V L
authors.initials: VL
authors.lastname: Guarda
authors.forename: M
authors.initials: M
authors.lastname: Perrissin
authors.forename: M C A
authors.initials: MC
authors.lastname: Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: S S
authors.initials: SS
authors.lastname: Brandão
authors.forename: F
authors.initials: F
authors.lastname: Thomasson
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
mesh_terms: D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C471060:4-thioxothiazolidin-2-one; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D013844:Thiazoles