title: Blood pressure, hematologic and erythrocyte fragility changes in children suffering from sickle cell anemia following ascorbic acid supplementation.
abstract: The effect of ascorbic acid supplementation (100 mg/day for 6 weeks) on blood pressure, packed cell volume, irreversibly sickled cells, per cent fetal hemoglobin, hemoglobin concentration, and erythrocyte osmotic fragility was assessed in children suffering from sickle cell anemia. Fifteen children whose ages ranged from 4 to 11 years (7.5 +/- 0.75 years) were studied. Ascorbic acid supplementation reduced systolic blood pressure by 10.9 +/- 3.4 mmHg (p < 0.01), diastolic blood pressure by 7.3 +/- 2.0 mmHg (p < 0.01) and mean arterial pressure by 9.4 +/- 2.6 mmHg (p < 0.01). It significantly increased packed cell volume (p < 0.001), hemoglobin concentration (p < 0.001) and per cent fetal hemoglobin (p < 0.001), but reduced per cent irreversibly sickled cells (p < 0.001). Ascorbic acid supplementation also abolished the long tail of the erythrocyte osmotic fragiligram and increased the resistance of the cells to lysis.
authors.affiliation: Department of Physiology, College of Medicine, University of Lagos, Nigeria. sjaja4@yahoo.com
authors.forename: S I
authors.initials: SI
authors.lastname: Jaja
authors.forename: A R
authors.initials: AR
authors.lastname: Ikotun
authors.forename: S
authors.initials: S
authors.lastname: Gbenebitse
authors.forename: E O
authors.initials: EO
authors.lastname: Temiye
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D004913:Erythrocytes, Abnormal / Q000187:drug effects; D005260:Female; D005319:Fetal Hemoglobin / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D008297:Male; D009549:Nigeria; D009996:Osmotic Fragility / Q000187:drug effects
chemical_list: D005319:Fetal Hemoglobin; D001205:Ascorbic Acid