title: [Invasive aspergillosis in autopsy material of patients treated at the Institute of Tuberculosis and Chest Diseases during the years 1993-2000].
abstract: The aim of this paper is an analysis of clinical documentation and results of autopsy of 21 patients (pts) who died of invasive aspergillosis (IA) in the Institute of Tuberculosis and Chest Diseases in years 1993-2000 and the assessment of predisposing factors for IA. In 17 pts IA was the main and in other 4 only an accessory cause of death. All pts were treated with corticosteroids and/or cytostatic drugs--because of lung cancer (11 pts), cancer in other site (2 pts), haematologic disorders (2 pts), Wegener's granulomatosis (1 pt), polymyositis (1 pt), idiopathic pulmonary fibrosis (1 pt) and other diseases (3 pts). In 15 out of 21 pts granulocytopenia was revealed (from 0.008 x 10(9)/L to 0.82 x 10(9)/L) on an average one month before death. In 15 pts IA was limited to the lungs, in 6 others there were also fungal lesions in brain, kidneys, liver, spleen and heart. Pts with disseminated form of IA had significantly lower granulocyte count and were treated with higher doses of corticosteroids than others. Immunosuppressive drugs and granulocytopenia can be regarded as predisposing factors. Fatal course of IA depended also on the late diagnosis.
authors.affiliation: III Kliniki Gruźlicy i Chorób Płuc, Warszawa.
authors.forename: P
authors.initials: P
authors.lastname: Remiszewski
authors.forename: R
authors.initials: R
authors.lastname: Langfort
authors.forename: B
authors.initials: B
authors.lastname: Podsiadło
authors.forename: J
authors.initials: J
authors.lastname: Kuś
authors.forename: M
authors.initials: M
authors.lastname: Płodziszewska
authors.forename: E
authors.initials: E
authors.lastname: Radzikowska
authors.forename: B
authors.initials: B
authors.lastname: Roszkowska
authors.forename: J
authors.initials: J
authors.lastname: Szopiński
authors.forename: W
authors.initials: W
authors.lastname: Tomkowski
authors.forename: L
authors.initials: L
authors.lastname: Wawrzyńska
authors.forename: E
authors.initials: E
authors.lastname: Wiatr
authors.forename: M
authors.initials: M
authors.lastname: Wierzbicka
authors.forename: J
authors.initials: J
authors.lastname: Załeska
authors.forename: M
authors.initials: M
authors.lastname: Załeska
authors.forename: J
authors.initials: J
authors.lastname: Zych
authors.forename: E
authors.initials: E
authors.lastname: Rowińska-Zakrzewska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000380:Agranulocytosis / Q000209:etiology; D001228:Aspergillosis / Q000473:pathology*; D001344:Autopsy; D002423:Cause of Death; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000382:microbiology; D006402:Hematologic Diseases / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008175:Lung Neoplasms / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011044:Poland; D017285:Polymyositis / Q000382:microbiology; D011658:Pulmonary Fibrosis / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents