[Fatty acid synthase: specific target for cancer therapy].
Fatty acids, the products of fatty acid synthesis, are essential components and forms of energy for cancer growth. Compared to normal human tissues, many common human cancers express elevated levels of fatty acid synthase (FAS), the important enzyme responsible for the synthesis of fatty acid, suggesting FAS can be a specific target for cancer therapy.
Li
Xiang-Hong
XH
Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China.
Hou
Yong-Tai
YT
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002569:Cerulenin / Q000494:pharmacology; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D014260:Triclosan / Q000494:pharmacology
D002569:Cerulenin; D014260:Triclosan; D002392:Catechin; D064429:Fatty Acid Synthases; C057580:gallocatechol