Influence of Na/Ca exchange stoichiometry on model cardiac action potentials.
Cardiac action potential simulations were done with the stoichiometry of the Na/Ca exchanger set a 4: 1. Using the Hilgemann-Noble (1987) model, this stoichiometry reduces the resting potential unless regulation by intracellular calcium is incorporated. The K(d) required for such regulation is consistent with current experimental estimates of this parameter.
Noble
Denis
D
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK. denis.noble@physiol.ox.ac.uk
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*; D006325:Heart Atria; D006352:Heart Ventricles; D007700:Kinetics; D008955:Models, Cardiovascular; D019831:Sodium-Calcium Exchanger / Q000502:physiology*
D019831:Sodium-Calcium Exchanger