Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase.
This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase were investigated. Compounds at a concentration of 500 microM exhibited 33.4-62.1% of inhibition on dopa oxidase activity of mushroom tyrosinase. Their inhibitory effects were higher than that of kojic acid (31.7%), a well known tyrosinase inhibitor. 2-(4-Methylphenyl)-1,3-selenazol-4-one (A) exhibited the strongest inhibitory effect among them dose-dependently and in competitive inhibition manner.
Koketsu
Mamoru
M
Department of Chemistry, Faculty of Engineering, Gifu University, Seoul, Korea.
Choi
Sang Yoon
SY
Ishihara
Hideharu
H
Lim
Beong Ou
BO
Kim
Hocheol
H
Kim
Sun Yeou
SY
D000363:Agaricales / Q000201:enzymology*; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology; D013329:Structure-Activity Relationship
C474089:2-(4-Methylphenyl)-1,3-selenazol-4-one; D001393:Azoles; D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; D011753:Pyrones; C011890:kojic acid; D014442:Monophenol Monooxygenase