title: Hitchhikers guide to the vacuole-mechanisms of cargo sequestration in the Cvt and autophagic pathways.
abstract: In the yeast Saccharomyces cerevisiae, precursor aminopeptidase I and alpha-mannosidase are selectively targeted via the Cvt and the autophagic pathways to the vacuole. Two studies now uncover the molecular basis of the selective sequestration of these two enzymes.
authors.affiliation: University of Stuttgart, Institute of Biochemistry, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Thumm
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism; D001343:Autophagy; D003593:Cytoplasm / Q000502:physiology; D005800:Genes, Fungal; D008247:Lysosomes / Q000502:physiology; D008361:Mannosidases / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological; D020675:Peroxisomes / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014617:Vacuoles / Q000502:physiology*; D043323:alpha-Mannosidase
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D008361:Mannosidases; D043323:alpha-Mannosidase; D000626:Aminopeptidases