[Studies on senility retarding effect of qiangshengye liquid].
OBJECTIVE
To observe the effect of Qiangshengye liquid on senility retarding in rats.


METHODS
The liquid was orally administrated to rats at doses of 3.3 g.kg-1 and 6.6 g.kg-1, and after Twenty-one days the activity of superoxide dismutase (SOD) in red blood cells and lipid peroxide(LPO) in plasma and in liver were examined respectively by spectrophotometry. Fluorescence polarization was used to evaluate the fluidity of erythrocyte membrane. In addition the anti-fatigue effect of the liquid in mice was detected.


RESULTS
The liquid can significantly increase the activity of SOD(P < 0.05) in red blood cells and decrease the contents of LPO in plasma (P < 0.05) and in liver(P < 0.01). The fluidity of erythrocyte membrane was also improved (P < 0.05).


CONCLUSIONS
Qiangshengye liquid can antagonize lipid peroxidation and therefore may be used for anti-fatigue and senility retarding purposes.
Yang
Q S
QS
Department of Pharmacology, Capital University of Medical Sciences, Beijing 100054, China.
Zhao
H L
HL
Chen
L
L
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005221:Fatigue / Q000188:drug therapy; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase