title: Clinical findings for residents near a polyurethane foam manufacturing plant.
abstract: Clinical findings for 38 community residents who complained of symptoms they attributed to exposure to air emissions from nearby fiber processing and polyurethane foam manufacturing facilities are reported. Common complaints included headache, mucosal irritation, shortness of breath, chest tightness, and wheezing. Airway hyperreactivity, measured by methacholine challenge, was observed in 8 individuals (22% of those tested), who also reported temporal relationships between exposure to visible emissions or odors and symptoms consistent with environmentally induced asthma. Six individuals (18.2%) had antibodies to at least 1 of the 3 common industrial diisocyanates. The number of individuals with antibodies to diisocyanates, coupled with the absence of other diisocyanate exposure, was highly suggestive of environmental exposure. The findings raised concern that some residents may have become sensitized to toluene diisocyanate.
authors.affiliation: Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 22710, USA. darce001@mc.duke.edu
authors.forename: Dennis
authors.initials: D
authors.lastname: Darcey
authors.forename: Hester J
authors.initials: HJ
authors.lastname: Lipscomb
authors.forename: Carol
authors.initials: C
authors.lastname: Epling
authors.forename: William
authors.initials: W
authors.lastname: Pate
authors.forename: Lorene P
authors.initials: LP
authors.lastname: Cherry
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000276:immunology; D000906:Antibodies / Q000097:blood; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007221:Industry; D008297:Male; D008875:Middle Aged; D009657:North Carolina; D011140:Polyurethanes / Q000009:adverse effects*; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D011795:Surveys and Questionnaires; D014051:Toluene 2,4-Diisocyanate / Q000276:immunology
chemical_list: D000393:Air Pollutants; D000906:Antibodies; D011140:Polyurethanes; D014051:Toluene 2,4-Diisocyanate