BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?
The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.
Powell
Simon N
SN
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
Willers
Henning
H
Xia
Fen
F
D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D024522:Genes, BRCA2; D006801:Humans; D008957:Models, Genetic; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control; D051135:Rad51 Recombinase; D011995:Recombination, Genetic
D024682:BRCA2 Protein; D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase