[Analysis of serologic typing error for HLA-A and HLA-B in Chinese].
Serological mistypings of HLA-A and HLA-B in 27 cases were analyzed. The results showed that for HLA-A and HLA-B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P < 0.05), but there was no significant difference between HLA-A and HLA-B typings. The frequencies of miss-assigned HLA-A and HLA-B specificities were A1 (66.7%), A3 (50.0%), A11 (13.5%), A9 (11.8%), A19 (7.1%), and B16 (50.0%), B48 (43.9%), B15 (16.7%), B40 (11.1%), B13 (10.0%) and B17 (9.1%). In conclusion, the serologic and DNA-based typing techniques should be reciprocally complementary in HLA-A and HLA-B typing.
Dai
Yu-Dong
YD
Nanjing Red Cross Blood Center, Nanjing 210008, China.
Sun
Qi-Jun
QJ
Zhang
Yi-Hong
YH
Yuan
Hong
H
Meng
Bo
B
D044466:Asian People; D002681:China; D015234:HLA-A Antigens / Q000145:classification* / Q000235:genetics; D015235:HLA-B Antigens / Q000145:classification* / Q000235:genetics; D006801:Humans; D012703:Serotyping
D015234:HLA-A Antigens; D015235:HLA-B Antigens