Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case-control study.
OBJECTIVE
The present case-control study was conducted to investigate the status of circulating lipid peroxidation and the enzymic and nonenzymic antioxidants of cervical cancer patients.


METHODS
Plasma thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and the levels of antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-S-transferase (GST), superoxide dismutase (SOD), vitamin C and vitamin E were estimated in circulation of thirty patients and an equal number of age matched normal subjects as control.


RESULTS
Significantly elevated levels of plasma TBARS and CD and significantly lowered levels of GSH, GPx, GST, SOD vitamin C and vitamin E were observed in cervical cancer patients as compared to controls. Our study reveals increased lipid peroxidation and possible breakdown of antioxidant status in patients with cervical carcinoma.


CONCLUSIONS
These results indicate that low levels of GSH, GPx, GST, SOD, vitamin E and vitamin C in the circulation of cervical cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells. Malnutrition may also be a significant cause for the increased prevalence of cervical cancer in women with a low socioeconomic status.
Manju
V
V
Department of Biochemistry, Annamalai University, Annamalainagar-608 002, India.
Kalaivani Sailaja
J
J
Nalini
N
N
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001790:Blood Physiological Phenomena; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D000975:Antioxidants