title: Effects of cysteamine--a somatostatin-inhibiting agent--on serum growth hormone levels and growth in juvenile grass carp (Ctenopharyngodon idellus).
abstract: Effects of cysteamine hydrochloride (CSH)-a somatostatin-inhibiting agent-on serum growth hormone (GH) levels and growth in juvenile grass carp (Ctenopharyngodon idellus) were studied. Intraperitoneal (i.p.) injection and single or 10-day feeding of different doses of CSH significantly increased serum GH levels. CSH and luteinizing hormone-releasing hormone analog (LHRH-A, D-Ala(6),Pro(9)-Net-LHRH), alone and in combination i.p. injection, and single or 10-day administration in diet resulted in an enhancement of serum GH contents; in addition, there was an additive, not synergistic effect of CSH and LHRH-A on elevation of serum GH levels. Ten day feeding of CSH, or CSH and LHRH-A, alone and in combination caused a significant increase in muscle RNA/DNA ratio. These results provide evidence that CSH significantly increases serum GH levels and promotes short-term growth in juvenile grass carp.
authors.affiliation: Institute of Aquatic Economic Animals and Key Laboratory of Guangdong Province for Aquatic Economic Animals, School of Life Sciences, Zhongshan University, Guangzhou 510275, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xiao
authors.forename: Hao-Ran
authors.initials: HR
authors.lastname: Lin
mesh_terms: D000821:Animal Feed; D000818:Animals; D017756:Aquaculture; D002347:Carps / Q000097:blood / Q000254:growth & development*; D003543:Cysteamine / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004347:Drug Interactions; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D018482:Muscle, Skeletal / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013004:Somatostatin / Q000037:antagonists & inhibitors* / Q000097:blood*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D003543:Cysteamine; D012313:RNA; D004247:DNA