title: A facile solution phase combinatorial synthesis of tetrasubstituted pyridines using the Bohlmann-Rahtz heteroannulation reaction.
abstract: The solution phase combinatorial Bohlmann-Rahtz reaction gives highly functionalized pyridine libraries from enamino esters and alkynones in a single synthetic step. Good product ratios and library purities were obtained in reactions catalyzed by zinc(II) bromide, the acid-catalyzed heteroannulation procedure offering considerable improvements over traditional methodology.
authors.affiliation: Department of Chemistry, Cardiff University, P.O. Box 912, Cardiff, CF10 3TB, United Kingdom. bagleymc@cf.ac.uk
authors.forename: Mark C
authors.initials: MC
authors.lastname: Bagley
authors.forename: James W
authors.initials: JW
authors.lastname: Dale
authors.forename: Maren
authors.initials: M
authors.lastname: Ohnesorge
authors.forename: Xin
authors.initials: X
authors.lastname: Xiong
authors.forename: Justin
authors.initials: J
authors.lastname: Bower