title: Reduced Tc-99m DMSA uptake in a patient with renal tubular acidosis: effect of acid-base imbalance.
abstract: Tc-99m dimercaptosuccinic acid (DMSA) is used as a renal cortical imaging agent to detect parenchymal abnormalities especially in children. Kidney uptake of DMSA provides an index for evaluation of a functional tubular mass, which depends on the renal blood flow and proximal tubular cell membrane transport function. We here report a boy with renal tubular acidosis, which has noticeably reduced uptake on his Tc-99m DMSA scintigraphy, despite a totally normal Tc-99m MAG-3 study. The case reported here clearly demonstrates a situation in which renal uptake of DMSA may be dissociated from a functional renal mass and the importance of acid-base balance which alters Tc-99m DMSA uptake.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University Medical Faculty, Ankara, Turkey. mcaglar@hacettepe.edu.tr
authors.forename: Meltem
authors.initials: M
authors.lastname: Caglar
authors.forename: Rezan
authors.initials: R
authors.lastname: Topaloğlu
mesh_terms: D000137:Acid-Base Imbalance / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D000141:Acidosis, Renal Tubular / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000493:pharmacokinetics; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D019783:Technetium Tc 99m Dimercaptosuccinic Acid