Lidocaine 2% gel versus lidocaine 4% unpreserved drops for topical anesthesia in cataract surgery: a randomized controlled trial.
OBJECTIVE
To compare intracameral levels and clinical efficacy of lidocaine 2% gel with lidocaine 4% unpreserved drops.


METHODS
Double-blind, randomized, one-surgeon, controlled trial.


METHODS
One hundred seven consecutive cataract cases eligible for topical anesthesia.


METHODS
Patients were randomly assigned to receive 20 mg of lidocaine either as lidocaine 2% gel (1 ml) or as lidocaine 4% unpreserved eyedrops (0.5 ml) before clear corneal phacoemulsification.


METHODS
Aqueous samples were taken to measure lidocaine intraocular levels. Intraoperative pain was quantified a few minutes after surgery using a 0 to 10 visual analog scale.


METHODS
Patients were asked to grade the degree to which they were bothered by tissue manipulation. The surgeon graded patients' cooperation. The anesthesiologist recorded any increase in pulse or blood pressure and the need for supplemental topical anesthesia or intravenous sedation. Duration of surgery and intraoperative complications were also recorded.


RESULTS
In the gel group intracameral lidocaine levels were significantly higher (P < 0.001) and patient-reported intraoperative pain scores were significantly lower (P = 0.026). Patients in the gel group were bothered by tissue manipulation to a lesser extent (P = 0.028), and their cooperation was better (P = 0.002). Increases in blood pressure were more frequent in the eyedrops group. Supplemental anesthesia was required in two cases (3.70%) in the gel group versus eight cases in the eyedrops group (15.09%). No correlation between intracameral lidocaine levels and intraoperative pain scores was found (r = -0.026, P = 0.789).


CONCLUSIONS
If administered by means of gel, the same amount of lidocaine gives significantly higher intracameral levels of lidocaine, better analgesia, better patient cooperation, and less need for intraoperative supplemental anesthesia. Lower pain scores do not correlate with intracameral lidocaine levels.
Bardocci
Antonio
A
Divisione Oculistica, Ospedale San Pietro-Fatebenefratelli, Rome, Italy.
Lofoco
Giorgio
G
Perdicaro
Serenella
S
Ciucci
Francesco
F
Manna
Livia
L
D000368:Aged; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D009883:Ophthalmic Solutions; D010146:Pain / Q000175:diagnosis; D010147:Pain Measurement; D018918:Phacoemulsification; D011446:Prospective Studies; D011795:Surveys and Questionnaires
D000779:Anesthetics, Local; D005782:Gels; D009883:Ophthalmic Solutions; D008012:Lidocaine