title: Accelerating water exchange for GdIII chelates by steric compression around the water binding site.
abstract: The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic GdIII complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA4- by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)]- is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, ICMB, BCH, Lausanne, Switzerland.
authors.forename: Robert
authors.initials: R
authors.lastname: Ruloff
authors.forename: Eva
authors.initials: E
authors.lastname: Tóth
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.forename: Raphaël
authors.initials: R
authors.lastname: Tripier
authors.forename: Henri
authors.initials: H
authors.lastname: Handel
authors.forename: André E
authors.initials: AE
authors.lastname: Merbach