title: Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.
abstract: This paper describes the synthesis and the antiplatelet activity of a series of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones. Some of these compounds show a dose-dependent activity and were found to be more active than their 5-substituted analogues.
authors.affiliation: Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Esapaña.
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
authors.forename: Nuria
authors.initials: N
authors.lastname: Fraiz
authors.forename: Matilde
authors.initials: M
authors.lastname: Yáñez
authors.forename: Reyes
authors.initials: R
authors.lastname: Laguna
authors.forename: Ernesto
authors.initials: E
authors.lastname: Cano
authors.forename: Enrique
authors.initials: E
authors.lastname: Raviña
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines