title: Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.
abstract: Angiotensin II (Ang II) and nitric oxide (NO) signaling pathways mutually regulate each other by multiple mechanisms. Ang II regulates the expression of NO synthase and NO production, whereas NO downregulates the Ang II type I (AT1) receptor. In addition, downstream effectors of Ang II and NO signaling pathways also interact with each other. A feedback mechanism between Ang II and NO is critical for normal vascular structure and function. Imbalance of Ang II and NO has been implicated in the pathophysiology of many vascular diseases. In this review, we focus on the diverse ways in which Ang II and NO interact and the importance of the balance between the signaling pathways activated by these mediators.
authors.affiliation: Center for Cardiovascular Research, University of Rochester, Rochester, NY, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Yan
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Kim
authors.forename: Toru
authors.initials: T
authors.lastname: Aizawa
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Berk
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000804:Angiotensin II; D009569:Nitric Oxide; D006152:Cyclic GMP