Asymmetric 1,4-addition of organosiloxanes to alpha,beta-unsaturated carbonyl compounds catalyzed by a chiral rhodium complex.
Highly enantioselective 1,4-addition of organosiloxanes to alpha,beta-unsaturated carbonyl compounds was found to be catalyzed by a chiral rhodium complex generated from [Rh(cod)(MeCN)(2)]BF(4) and (S)-BINAP. Both (E)- and (Z)-1-alkenyl groups as well as aryl groups can be introduced enantioselectively into the beta-position of a variety of ketones, esters, and amides. [reaction--see text]
Oi
Shuichi
S
Department of Materials Chemistry, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan. oishu@aporg.che.tohoku.ac.jp
Taira
Akio
A
Honma
Yoshio
Y
Inoue
Yoshio
Y