title: [Modern approaches to pharmacotherapy of diabetes mellitus type II].
abstract: The pharmacological approaches to the treatment of type 2 diabetes mellitus were reviewed. Special attention was paid to the new therapeutic agents that are able to decrease plasma glucose levels. The possible mechanisms of the hypoglycemic effects are discussed. Briefly, repaginide, nateglinede and alpha-glucosidase inhibitors prevent postprandial hypoclycemia while thiazaolidinediones improve the sensitivity to insulin and vanadium compounds act as an insulin action enhancer.
authors.affiliation: Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya 10, Moscow 119121. kovelman@ibmh.msk.su
authors.forename: I R
authors.initials: IR
authors.lastname: Kovel'man
authors.forename: A I
authors.initials: AI
authors.lastname: Tochilkin
authors.forename: N F
authors.initials: NF
authors.lastname: Beliaeva
authors.forename: V K
authors.initials: VK
authors.lastname: Gorodetskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Kniazhev
authors.forename: S B
authors.initials: SB
authors.lastname: Tkachenko
authors.forename: L L
authors.initials: LL
authors.lastname: Semenov
authors.forename: N V
authors.initials: NV
authors.lastname: Semenova
mesh_terms: D000284:Administration, Oral; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents