Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse.
OBJECTIVE
To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene.


METHODS
Case report.


METHODS
University-affiliated andrology practice within family practice clinic.


METHODS
A 30-year-old male.


METHODS
Clomiphene citrate, 100-mg challenge for 5 days, followed by treatment at same dose for 2 months.


METHODS
Clinical symptoms, androgen decline in aging male questionnaire, total T, FSH, LH.


RESULTS
Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.


CONCLUSIONS
Clomiphene citrate is used typically in helping to restore fertility in females. This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.
Tan
Robert S
RS
Department of Family and Community Medicine, University of Texas Health Sciences Center, Houston, Texas 77030, USA. robert.s.tan@uth.tmc.edu
Vasudevan
Deepa
D
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009277:Nandrolone; D010902:Pituitary Gland / Q000503:physiopathology; D019966:Substance-Related Disorders; D013737:Testis / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D045930:Anabolic Agents; D004965:Estrogen Antagonists; D002996:Clomiphene; D013739:Testosterone; D009277:Nandrolone; D007986:Luteinizing Hormone