[Research on the transformation of ginsenoside Rg1 by intestinal flora].
OBJECTIVE
The decomposition of Ginsenoside Rg1(Rg1) by intestinal bacteria in rats or human was investigated both in vitro and in vivo.


METHODS
The decompositions were investigated by means of thin-layer chromatography and Electron spurt ion mass.


RESULTS
It was found that Rg1 was converted into two metabolites [Rh1 and 20(S)-protopanaxatriol(20S-Ppt)] by human intestinal bacteria in vitro, while three compounds [Rh1, F1, and 20(S)-Ppt] were detected in rat intestinal bacteria metabolism in vitro and in vivo.


CONCLUSIONS
The decomposition and/or metabolism of Rg1 in rat and human digestive tract was confirmed. The mode of metabolism in rat is Rg1-->Rh1(F1)-->Ppt, while in human it is Rg1-->Rh1-->Ppt.
Wang
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Y
Research Centre of New Drug, Changchun College of Traditional Chinese Medicine, Changchun 130021, Jinlin, China.
Liu
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Wang
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Wang
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D000818:Animals; D018407:Bacterial Physiological Phenomena; D036145:Ginsenosides / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D036145:Ginsenosides; C035054:ginsenoside Rg1