title: Corticospinal excitability in human sleep as assessed by transcranial magnetic stimulation.
abstract: The excitability of the corticospinal system was studied in 23 healthy subjects in sleep stages NREM2, NREM4, REM, and wakefulness using transcranial magnetic stimulation. Assessment of motor thresholds, stimulus-response curves, and latencies of motor evoked potentials shows activation of the fast-conducting corticospinal fibers in all sleep stages and a neuronal recruitment pattern similar to wakefulness, however, at a lower level of excitability and with significant differences between sleep stages.
authors.affiliation: Neurologische Klinik und Poliklinik, Charité, Campus Virchow-Klinikum, Berlin, Germany. p.grosse@ion.ucl.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Grosse
authors.forename: R
authors.initials: R
authors.lastname: Khatami
authors.forename: F
authors.initials: F
authors.lastname: Salih
authors.forename: A
authors.initials: A
authors.lastname: Kühn
authors.forename: B-U
authors.initials: BU
authors.lastname: Meyer
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012016:Reference Values; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM; D013116:Spinal Cord / Q000503:physiopathology*