[Studies on metal porphyrins as two-functional mimic of enzyme].
In this study, four metal porphyrins (tetraphenylporphyrinesulfonatoiron, tetraphenylporphyrinesulfon-atocopper, tetraphenylporphyrinesulfonatomanganese, and tetraphenyl porrphyrinesulfonatocobalt) were used as dual function mimicry of superoxide dismutase (SOD) and catalase (CAT). The first function, scavenging O2.-, has been proved by using riboflavine-methionine photoreduction method in the concentration range of 10(-5)-10(-6) mol/L. The second function, scavenging H2O2, has been demonstrated by means of spectrophotometry, and the percentage of decomposing H2O2 increases with the concentration of the imitating compounds. Metal porphyrins, SOD and CAT were measured by the liver homogenate technique of mice and the results showed that they had obvious action of decreasing the lipid peroxidation. Tetraphenylporphyrinesulfonatomanganese was measured by isolated ischemia reperfusion heart of rats. The results indicated that the Mn-TPPS4 could reduce the damages of active oxygen and had evidently protective effects on isolated ischemia-reperfusion mocardium of rats.
Feng
Q
Q
Department of Chemistry, School of Medical Sciences, Tongji Medical University, Wuhan 430030.
Liu
L
L
He
Y
Y
Wang
H
H
Lu
Y
Y
Liu
Y
Y
Wei
L
L
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D002734:Chlorophyll / Q000494:pharmacology; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D006418:Heme / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D011166:Porphyrins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000494:pharmacology*
D016166:Free Radical Scavengers; D011166:Porphyrins; D002734:Chlorophyll; D006418:Heme; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase