The Golgi apparatus at the cell centre.
In non-polarised mammalian cells, the Golgi apparatus is localised around the centrosome and actively maintained there. Microtubules and molecular motor activity are required for determining both the localisation and organisation of the Golgi apparatus. Other factors, however, also appear necessary for regulating both the static steady-state distribution of this organelle and its relationship with microtubule minus-end-anchoring activities of the centrosome. Several non-motor microtubule-binding proteins have now been found to be associated with the Golgi apparatus. Recent advances suggest that, in addition to important roles in cell motility, polarisation and differentiation, the interplay between Golgi apparatus and centrosome could participate in other physiological processes such as intracellular signalling, mitosis and apoptosis.
Rios
Rosa M
RM
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Reina Mercedes 6, 41012-Sevilla, Spain. rmrios@us.es
Bornens
Michel
M
D000818:Animals; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008868:Microtubule Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D020409:Molecular Motor Proteins / Q000502:physiology; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D008868:Microtubule Proteins; D020409:Molecular Motor Proteins