[Effects of chuanxiong-chishao dispensing ratio on the pharmacokinetics of paeoniflorin in the canine].
OBJECTIVE
To explore the effects of dispensing ratio of Chinese herbs on the pharmacokinetic characteristics of effective components.


METHODS
Paeoniflorin (PF) in serum was determined by RP-HPLC with UV-detector. The concentration-time data were fitted using 3P87 Pharmacokinetic Program, and the pharmacokinetic parameters were compared by t-test.


RESULTS
The concentration-time curves of PF in both groups of Chuanxiong: Chishao 1:2 and 2:1 Xiongshao Pharmaceutics administrated intragastrically fitted open one compartment model. Parameters of Chuanxiong: Chishao 1:2 and 2:1 groups: Ka = 0.0082 +/- 0.0010 and 0.0088 +/- 0.0011(min-1), Ke = 0.0060 +/- 0.0015 and 0.0071 +/- 0.0008(min-1), t1/2Ka = 86.10 +/- 12.38 and 79.11 +/- 18.69(min), t1/2Ke = 119.95 +/- 27.23 and 98.14 +/- 10.82(min), tpeak = 169.16 +/- 21.18 and 149.39 +/- 29.51(min), Cmax = 3845.89 +/- 716.70 and 1635.81 +/- 230.95 (micrograms.L-1) respectively. The pharmacokinetic parameters of the two groups had no statistically significant differences (p > 0.05).


CONCLUSIONS
Different formulae of Chinese herbs do not always result in changes of pharmacokinetic characteristics of some one component.
Zhang
Z
Z
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China.
Yan
Y F
YF
Chen
K
K
D000818:Animals; D001565:Benzoates / Q000493:pharmacokinetics*; D001952:Bridged-Ring Compounds / Q000493:pharmacokinetics*; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005960:Glucosides / Q000493:pharmacokinetics*; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; C015423:peoniflorin; D006027:Glycosides