title: Women's angiographic vitamin and estrogen trial: design and methods.
abstract: The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more angiographically documented coronary stenoses of 15-75% at baseline were assigned in a 2 x 2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years.
authors.affiliation: Department of Medicine, George Washington University, Washington, DC, USA. jhsia@mfa.gwu.edu
authors.forename: Judith
authors.initials: J
authors.lastname: Hsia
authors.forename: Edwin L
authors.initials: EL
authors.lastname: Alderman
authors.forename: Joel I
authors.initials: JI
authors.lastname: Verter
authors.forename: William J
authors.initials: WJ
authors.lastname: Rogers
authors.forename: Paul
authors.initials: P
authors.lastname: Thompson
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Cobb
authors.forename: Pamela
authors.initials: P
authors.lastname: Ouyang
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Tardif
authors.forename: Lyall
authors.initials: L
authors.lastname: Higginson
authors.forename: Vera
authors.initials: V
authors.lastname: Bittner
authors.forename: Ivan
authors.initials: I
authors.lastname: Barofsky
authors.forename: Michael
authors.initials: M
authors.lastname: Steffes
authors.forename: David J
authors.initials: DJ
authors.lastname: Gordon
authors.forename: Michael
authors.initials: M
authors.lastname: Proschan
authors.forename: Naji
authors.initials: N
authors.lastname: Younes
authors.forename: David
authors.initials: D
authors.lastname: Waters
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002170:Canada; D017023:Coronary Angiography; D003327:Coronary Disease / Q000517:prevention & control*; D023381:Endpoint Determination; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D012107:Research Design; D014481:United States
chemical_list: D000975:Antioxidants