title: [Combined use of killed vaccines and immunomodulator ridostin for urgent prevention of epidemic stomatitis, Aujeszky disease and carnivore plague in experiment].
abstract: Results of experimental studies of mice and pigs infected with foot-and-mouth disease virus, minks infected with Aujeszky's disease virus, and dogs infected with canine distemper virus are described. In animals with foot-and-mouth disease and Aujeszky's disease, combined treatment with killed vaccine and immunomodulator Ridostin by the scheme of urgent prophylaxis (3 days before infection) caused 75% (foot-and-mouth disease) and 100% (Aujeszky's disease) prevention of animal death and development of generalized infection. The use of Ridostin by the scheme of urgent prophylaxis in a canine distemper infection focus arrested clinical symptoms of the disease in 50% of animals received immunomodulator. Clinical symptoms of canine distemper in the other dogs treated with immunomodulator were manifested in a mild form, and their appearance was delayed to 23-25 days after contact with infected animal.
authors.forename: I F
authors.initials: IF
authors.lastname: Barinskiĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Ulasov
authors.forename: V M
authors.initials: VM
authors.lastname: Kravchenko
authors.forename: A S
authors.initials: AS
authors.lastname: Toloknov
authors.forename: I A
authors.initials: IA
authors.lastname: Lycheva
authors.forename: L M
authors.initials: LM
authors.lastname: Alimbarova
authors.forename: N P
authors.initials: NP
authors.lastname: Kosiakova
mesh_terms: D000818:Animals; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology; D004285:Dogs; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D006564:Herpesviridae / Q000276:immunology; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D008907:Mink; D010849:Picornaviridae / Q000276:immunology; D011557:Pseudorabies / Q000517:prevention & control*; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D012331:RNA, Fungal / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D014765:Viral Vaccines; C076741:ridostin