The threonine story.
L-Threonine is an essential amino acid which has recently been brought into agricultural industry for balancing the livestock feed. L-Threonine is produced by microbial synthesis using glucose or sucrose as substrates. For the process to be cost-effective, the microbial strain must be capable of threonine overproduction. This paper reviews the biochemical pathways of L-threonine synthesis in bacteria and the regulation of these pathways, the principles and the techniques of constructing high-producing strains, and the most efficient strains thus developed.
Debabov
Vladimir G
VG
State Research Institute of Genetics and Selection of Industrial Microorganisms, 1st Dorozhnyi proezd, Moscow 113545, Russia. boss@genetika.ru
D000438:Alcohols / Q000378:metabolism; D003352:Corynebacterium / Q000145:classification / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D005285:Fermentation; D015964:Gene Expression Regulation, Bacterial; D015202:Protein Engineering; D011786:Quality Control; D011995:Recombination, Genetic; D013045:Species Specificity; D013912:Threonine / Q000096:biosynthesis* / Q000235:genetics*
D000438:Alcohols; D013912:Threonine