title: Organ preservation strategies in the treatment of laryngeal cancer.
abstract: For most patients, a total laryngectomy should not be used as the initial treatment for any stage laryngeal tumor. The goal in treating a patient with laryngeal cancer must be not only to cure but also to provide the best functional outcome for the patient. In the United States, the treatment of laryngeal cancer has moved from radical surgery toward a more conservative approach involving definitive radiotherapy and chemotherapy, with extirpative surgery held in reserve for salvage. In Europe, there has been increasing reliance on limited endoscopic cordectomy procedures for early tumors and the use of function-preserving surgical approaches for more advanced lesions. Careful monitoring of the conservatively treated patient is mandatory to allow for early salvage of failures to the original therapy. Because of the high costs of hospitalization, the direct medical costs attributable to conservative approaches are equal to or less than the costs for more radical surgical resections. Even if survivals are only equivalent, organ preservation approaches should be the treatment of choice for most patients.
authors.affiliation: Department of Radiation Oncology, Box 356043, University of Washington Medical Center, Seattle, WA 98195-6043, USA. georgel@uwashington.edu
authors.forename: George E
authors.initials: GE
authors.lastname: Laramore
authors.forename: Marc D
authors.initials: MD
authors.lastname: Coltrera
mesh_terms: D003131:Combined Modality Therapy; D003413:Cricoid Cartilage / Q000601:surgery; D004825:Epiglottis / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D009367:Neoplasm Staging; D016879:Salvage Therapy