title: Necessity of screening for multiple primary cancers in patients with esophageal cancer.
abstract: This study divided patients with esophageal cancer and multiple primary cancers into two groups, a head and neck cancer (HNC) group and a non-head and neck cancer (NHNC) group. These groups were then evaluated on the basis of clinical and pathological studies. Among 92 patients with esophageal cancer as one of multiple primary cancers, 38 (41.8%) were assigned to the HNC group. The following characteristics distinguished patients in the HNC group from those in the NHNC group: (1) younger age; (2) shorter interval between diagnosis of metachronous cancers; (3) many displayed superficial esophageal cancer. Among the cases in which esophageal cancer was discovered synchronously with head and neck cancer, head and neck cancers were discovered before esophageal cancer; and (4) many patients displayed esophageal dysplasia, and many had multiple esophageal cancers. In the present study, we demonstrated the necessity of screening for multiple primary cancers in patients with esophageal cancer.
authors.affiliation: Department of Oncological Science Surgery II, Oita Medical University, Oita, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kato
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Takeno
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Wada
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D002423:Cause of Death; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D018570:Risk Assessment