title: Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying.
abstract: The effect of rhizomes of Atractylodes lancea on gastric disorders, in particular, the delay in gastric emptying induced by N(G)-nitro-L-arginine in rats, was investigated. Intragastric treatment with an aqueous extract (250 mg/kg) and its lipophilic fractions (4 mg/kg) significantly improved delayed gastric emptying. The major constituents of the lipophilic fraction were two sesquiterpens, hinesol and beta-eudesmol, and four known polyacetylenic compounds, atractylodin, atractylodinol, acetylatractylodinol and 4,6,12-tetradecatriene-8,10-diyne-1,3,14-triol. The activity was found in the four polyacetylenic compounds at a similar potency, but not in the two sesquiterpens. To clarify the effect of the four polyacetylenic compounds in this extract, we attempted to evaluate the activity of atractylodin, as representative, at a dose of 0.2 mg/kg based on the total amounts (0.2 mg/250 mg aqueous extract) of the four polyacetylenic compounds. In addition, atractylodin improved the delay in gastric emptying at between 0.1 and 0.3 mg/kg in a dose-dependent manner. These results suggest that the aqueous extract improved the delayed gastric emptying, and polyacetylenic compounds contributed to its activity.
authors.affiliation: Kampo and Pharmacognosy Laboratory, Tsumura and Co, 3586 Yoshiwara Ami-machi Inashiki-gun, Ibaraki 300-1192, Japan. nakai_youichirou@mail.tsumura.co.jp
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Nakai
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kido
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kase
authors.forename: Iwao
authors.initials: I
authors.lastname: Sakakibara
authors.forename: Masami
authors.initials: M
authors.lastname: Higuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry*
chemical_list: D005663:Furans; D010936:Plant Extracts; C106914:atractylodin