title: Annular crystalline keratopathy in association with immunoglobulin therapy for pyoderma gangrenosum.
abstract: OBJECTIVE
  To report on a patient with a clinical presentation of annular crystalline keratopathy after immunoglobulin therapy for pyoderma gangrenosum.
  
  
  METHODS
  Case report of a 6-year-old boy with biopsy-proven history of pyoderma gangrenosum who had undergone several cycles of systemic immunoglobulin therapy. The literature on ocular manifestations associated with pyoderma gangrenosum was reviewed.
  
  
  RESULTS
  One year after the last cycle, the patient complained of the sudden onset of photophobia. Slit-lamp biomicroscopy revealed bilateral symmetric crystalline deposits in an annular region of the cornea. Because visual acuity was not reduced, specific therapy was not initiated. Symptoms could be reduced by the prescription of medical edged filter lenses.
  
  
  CONCLUSIONS
  Annular crystalline corneal deposits may be associated with immunoglobulin therapy or represent a hitherto unknown ocular complication of pyoderma gangrenosum.
authors.affiliation: Department of Ophthalmology, Friedrich-Alexander-University Erlangen-Nürnberg in Erlangen, Erlangen, Germany.
authors.forename: Maike
authors.initials: M
authors.lastname: Budde
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: Gusek-Schneider
authors.forename: Ursula
authors.initials: U
authors.lastname: Mayer
authors.forename: Berthold
authors.initials: B
authors.lastname: Seitz
mesh_terms: D002648:Child; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects* / Q000379:methods; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity
chemical_list: D016756:Immunoglobulins, Intravenous