title: Extraosseous accumulation of 99mTc phosphonate complexes in primary brain tumor evaluated with SPECT.
abstract: Although extraosseous accumulations of 99mTc phosphate complexes are phenomena which can often be seen, no case showing extraosseous accumulation to brain tumor on SPECT has been reported. We report here two cases of primary brain tumor showing extraosseous accumulation of 99mTc phosphate in bone SPECT. 201Tl SPECT also showed increased 201Tl uptake by the tumor. Comparing bone SPECT with 201Tl SPECT, the regions of abnormality of both SPECTs were very similar in the case of glioblastoma, but in the case of malignant lymphoma the region showing intense uptake of 99mTc-MDP was smaller than that on 201Tl SPECT. It was revealed that bone SPECT is more useful in the assessment of extraosseous accumulation to a primary brain tumor than conventional bone scintigraphy.
authors.affiliation: Division of Nuclear Medicine, Chiba Cancer Center, Japan. asuzuki@internet.chiba-cc.pref.chiba.jp
authors.forename: Aya
authors.initials: A
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Togawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Kuyama
authors.forename: Tadaki
authors.initials: T
authors.lastname: Nakahara
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Yui
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iuchi
authors.forename: Masaru
authors.initials: M
authors.lastname: Oga
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Osato
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D004164:Diphosphonates / Q000493:pharmacokinetics; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012886:Skull / Q000000981:diagnostic imaging* / Q000378:metabolism; D013667:Technetium / Q000493:pharmacokinetics; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D004164:Diphosphonates; D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D013669:Technetium Tc 99m Medronate