A novel synthesis of 5-functionalized oxazolidin-2-ones from enantiomerically pure 2-substituted N-[(R)-(+)-alpha-methylbenzyl]aziridines.
5-Funtionalized enantiomerically pure oxazolidin-2-ones were prepared in one pot from commercially available chiral aziridines bearing an electron-withdrawing group at C-2 with retention of the configuration in high yields by regioselective aziridine ring-opening followed by intramolecular cyclization.
Sim
Tae Bo
TB
Department of Chemistry, Sogang University, Seoul, Korea.
Kang
Se Hun
SH
Lee
Kun Su
KS
Lee
Won Koo
WK
Yun
Hoseop
H
Dong
Yongkwan
Y
Ha
Hyun-Joon
HJ