Hantavirus immunology.
Two clinical syndromes are associated with hantavirus infection in humans: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Autopsy findings typically reveal a common feature of increased permeability in microvascular beds, suggesting vascular endothelium is a prime target for virus infection. Endothelial cells are susceptible to hantavirus infection; however, virus does not cause cytopathic effects, to explain increased endothelium permeability. Therefore, immune mechanisms were suggested to play a crucial role in hantavirus pathogenesis. In this review, we summarize data on hantavirus-induced immune disturbances and discuss their implication in capillary leakage caused by hantavirus infection.
Khaiboullina
Svetlana F
SF
Department of Microbiology and Cell and Molecular Biology Program, School of Medicine, University of Nevada, Reno, Nevada 89577, USA.
St  Jeor
Stephen C
SC
D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology* / Q000821:virology; D006476:Orthohantavirus / Q000276:immunology / Q000472:pathogenicity*; D018804:Hantavirus Pulmonary Syndrome / Q000276:immunology* / Q000503:physiopathology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans