title: Identification of t(15;17) and a segmental duplication of chromosome 11q23 in a patient with acute myeloblastic leukemia M2.
abstract: A 32-year-old man was newly diagnosed with acute myelocytic leukemia, classified as acute myeloblastic leukemia with maturation (AML-M2) according to the French-American-British classification system. Conventional chromosome analysis before chemotherapy treatment revealed an abnormal karyotype: a possible segmental duplication of 11q23, plus a translocation between chromosomes 15 and 17 [t(15;17) (q22;q21.1)] in the majority of cells analyzed. Fluorescence in situ hybridization analysis using commercially available probes confirmed the cytogenetic findings. To our knowledge, this is the first report of a combination of t(15;17) and a segmental duplication of 11q23 in a patient with AML-M2.
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. shibo-li@ouhsc.edu
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.forename: William F
authors.initials: WF
authors.lastname: Kern
authors.forename: Dario
authors.initials: D
authors.lastname: Andrade
authors.forename: Jean E
authors.initials: JE
authors.lastname: Forsberg
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Bates
authors.forename: John J
authors.initials: JJ
authors.lastname: Mulvihill
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D020440:Gene Duplication; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*