Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition.
[reaction: see text] A copper-free palladium-mediated cleavage of O/N-propargyl bonds in aqueous media has been investigated, affording a mild and convenient method for the deprotection of phenols and anilines. The methodology could be utilized for the selective removal of propargyl groups from aryl ethers and amines without affecting a variety of unprotected functional groups present in the substrates. The mechanism and scope of the reaction is discussed.
Pal
Manojit
M
Chemistry-Discovery Research, Dr Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500050, India. manojitpal@drreddys.com
Parasuraman
Karuppasamy
K
Yeleswarapu
Koteswar Rao
KR