Protein-protein interactions during mammalian DNA single-strand break repair.
The genetic stability of living cells is continually threatened by endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of single-strand breaks that arise in each cell every day. If left unrepaired, such breaks can give rise to potentially clastogenic or lethal chromosomal double-strand breaks. This article summarizes our current understanding of how mammalian cells detect and repair single strand breaks, and provides insights into novel polypeptide components of this process.
Caldecott
K W
KW
Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RH, UK. k.w.caldecott@sussex.ac.uk
D000818:Animals; D016923:Cell Death; D004249:DNA Damage; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D020798:Two-Hybrid System Techniques
D004277:DNA, Single-Stranded