title: Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3.
abstract: [reaction: see text] Catalytic Sc(OTf)(3) greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl-aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.
authors.affiliation: Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton S017 1BJ, United Kingdom.
authors.forename: Mizio
authors.initials: M
authors.lastname: Matteucci
authors.forename: Gurdip
authors.initials: G
authors.lastname: Bhalay
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley