title: No effects of estrogen receptor overexpression on gonadal sex differentiation and reversal in medaka fish.
abstract: In order to elucidate a possible role of estrogen receptor in the gonadal sex differentiation and the sex reversal with sex steroids, we examined for the formation of testis or ovary in transgenic medaka fish overexpressing the medaka estrogen receptor under the constitutive medaka beta-actin promoter. The transgenic fish underwent the genetically determined gonadal differentiation and showed the same sex-reversal rates as those of wild-type non-transgenic fish after treatments with estrogen and androgen. These results present invaluable data to reconsider the role of estrogen receptor in the gonadal sex determination.
authors.affiliation: Center for Gene Science, Hiroshima University, Kagamiyama 1-4-2, Higashi-hiroshima 739-8527, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawamura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Omura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sakai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamashita
mesh_terms: D000728:Androgens / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D030801:Animals, Genetically Modified; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology; D005260:Female; D015870:Gene Expression; D057850:Hermaphroditic Organisms; D008297:Male; D009990:Oryzias / Q000196:embryology* / Q000235:genetics*; D010053:Ovary / Q000196:embryology; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D019849:Sex Determination Processes; D013737:Testis / Q000196:embryology
chemical_list: D000728:Androgens; D004967:Estrogens; D011960:Receptors, Estrogen