title: Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report.
abstract: The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei. Metastases occurred 4 months after incomplete resection with prior therapeutic embolization. The recurrent tumor in turn displayed anaplastic features and an increased Ki-67 labeling index. Genetic alterations in such morphologically benign meningiomas have been implicated in the malignant development and progression of these tumors.
authors.affiliation: Department of Pathology, University Clinic Hospital of Valencia, University of Valencia, Spain. jose.m.cerda@uv.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Cerdá-Nicolás
authors.forename: Concha
authors.initials: C
authors.lastname: Lopez-Gines
authors.forename: Miguel
authors.initials: M
authors.lastname: Perez-Bacete
authors.forename: Pedro
authors.initials: P
authors.lastname: Roldan
authors.forename: Fernando
authors.initials: F
authors.lastname: Talamantes
authors.forename: José
authors.initials: J
authors.lastname: Barberá
mesh_terms: D000368:Aged; D020732:Cytogenetic Analysis; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D013160:Splenic Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery