[The enantiomeric separation of aromatic alcohol amino drugs by thin-layer chromatography].
Two chiral aromatic alcohol amino drugs, Labarol and Bataroc, were resolved by thinlayer chromatography (TLC) on the silica gel GF254 plates (2.5 cm x 10 cm), by using the ammonium-D-10-camphorsulfonate (CSA) as chiral ion-pair interaction agent which was added to the mobile phase in the ammonium form. All developments were carried out at lower temperature (2-4 degrees C, in a refrigerator) in small glass jars of 250 mL volume. These two drugs were not resolved at room temperature (15-30 degrees C). Analytical reagent grade methanol and dichloromethane can be directly used as mobile phase without further drying. The chiral separation occured over a range from 40% to 70% (optimum 67%) dichloromethane in the mobile phase volume ratio and 55% to 80% (optimum 60%) dichloromethane in the mobile phase volume ratio. These separation conditions were easily obtained. This method is relatively inexpensive and attractive.
Li
G
G
Department of Chemistry, Shandong University, Jinan, 250100.
Huang
M
M
Yang
G
G
Wu
G
G
Du
A
A
Su
Y
Y
D000605:Amino Alcohols; D002164:Camphor / Q000031:analogs & derivatives*; D002855:Chromatography, Thin Layer; D007741:Labetalol / Q000032:analysis / Q000737:chemistry*; D008790:Metoprolol / Q000032:analysis / Q000737:chemistry*; D013237:Stereoisomerism
D000605:Amino Alcohols; D002164:Camphor; C006881:10-camphorsulfonic acid; D008790:Metoprolol; D007741:Labetalol