title: Effects of estrogenic and antiandrogenic compounds on the testis structure of the adult guppy (Poecilia reticulata).
abstract: Sexually mature male guppies (Poecilia reticulata) were exposed to 17beta-estradiol, 4-tert-octylphenol, bisphenol A, flutamide, p,p'-DDE, or vinclozolin to determine the effects of these estrogenic or antiandrogenic substances on the testis structure. Flutamide, p,p'-DDE, 4-tert-octylphenol, and bisphenol A exposure caused similar effects. These included a reduced number of spermatogenetic cysts and an increased number of spermatozeugmata in the ducts. These effects are indicative of a blocked spermatogonial mitosis. 17beta-Estradiol produced effects different from those of the other compounds studied. The effects were seen as an increased number of hypertrophied Sertoli cells/efferent duct cells. The mammalian antiandrogen vinclozolin had no observable effects on the testis structure when given in doses of 1, 10, or 100 microg/mg food.
authors.affiliation: Institute of Biology, University of Southern Denmark-Odense, DK-5230 Odense M, Denmark. kinnberg@biology.edu.dk
authors.forename: Karin
authors.initials: K
authors.lastname: Kinnberg
authors.forename: Gunnar
authors.initials: G
authors.lastname: Toft
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects*; D000818:Animals; D004703:Endocrine System / Q000187:drug effects; D004967:Estrogens / Q000009:adverse effects*; D008297:Male; D011036:Poecilia / Q000502:physiology*; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000002:abnormalities* / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D000726:Androgen Antagonists; D004967:Estrogens; D014874:Water Pollutants, Chemical