title: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
abstract: This review summarizes recent findings and common principles for intramembrane-cleaving proteases that catalyse critical steps in cell regulation and signalling and which are involved in diseases such as Alzheimer's disease and hepatitis C virus infection.
authors.affiliation: Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), ETH-Hoenggerberg, 8093 Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Weihofen
authors.forename: Bruno
authors.initials: B
authors.lastname: Martoglio
mesh_terms: D000818:Animals; D020134:Catalytic Domain / Q000502:physiology; D002462:Cell Membrane / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D006868:Hydrolysis; D007425:Intracellular Membranes / Q000201:enzymology*; D008565:Membrane Proteins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D053764:Presenilin-1
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D010455:Peptides; D053764:Presenilin-1; D010450:Endopeptidases; D008666:Metalloendopeptidases; C120654:MBTPS2 protein, human