Influence of haemoglobin concentration and peripheral muscle pO2 on tumour oxygenation in advanced head and neck tumours.
Haemoglobin concentrations and tumour-pO(2) were evaluated pre-therapy in 30 patients with head and neck cancers. Anterior tibialis muscle-pO(2) was additionally measured in 16 of these patients. Tumour-pO(2) was lower in the most anaemic patients (P=0.032) and correlated with muscle-pO(2) (r=0.809, P<0.001). These results suggest that haemoglobin concentration influences tumour-oxygenation.
Clavo
Bernardino
B
Department of Radiation Oncology and Research Unit, Dr. Negrín Hospital, C/Barranco la Ballena s/n, 35020 Las Palmas (Canary Islands), Spain.
Pérez
Juan L
JL
López
Laura
L
Suárez
Gerardo
G
Lloret
Marta
M
Morera
Jesús
J
Macías
David
D
Martínez
José C
JC
Santana
Maite
M
Hernández
María A
MA
Robaina
Francisco
F
Günderoth
Martina
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D019069:Cell Respiration; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D009367:Neoplasm Staging; D010101:Oxygen Consumption / Q000502:physiology*; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D015415:Biomarkers; D006454:Hemoglobins