Post-transcriptional regulation of human iron metabolism by iron regulatory proteins.
In mammalian iron metabolism, ferritin, transferrin receptor and several other iron metabolism genes are post-transcriptionally regulated. Iron regulatory proteins 1 and 2 are cytosolic proteins that bind to RNA stem-loops known as iron-responsive elements in several transcripts. We have studied the role of these proteins in knockout mice and discovered that misregulation of iron metabolism can be a primary cause of neurodegeneration.
Rouault
Tracey A
TA
Section on Human Iron Metabolism, Cell Biology and Metabolism Branch, NICHD/NIH, Building 18, Room 101, Bethesda, MD 20892, USA. trou@helix.nih.gov
D000818:Animals; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice
D035925:Iron-Regulatory Proteins; D005293:Ferritins; D007501:Iron