Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer.
Itakura
Haruka
H
University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA.
Vaughn
David
D
Haller
Daniel G
DG
O'Dwyer
Peter J
PJ
D000368:Aged; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism*; D007654:Ketoconazole / Q000378:metabolism*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000378:metabolism*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D003577:Cytochrome P-450 Enzyme System; D019821:Simvastatin; D007654:Ketoconazole