[Evaluation of methods of drug release rate in root canal disinfection controlled-release delivery system containing metronidazole].
OBJECTIVE
To measure the release rate of drug in controlled-release delivery system containing metronidazole.


METHODS
Drug release tests in vitro, in vivo and through the roots of extracted teeth were performed. The release rate of metronidazole was calculated after 1 day, 3 days, 7 days and 10 days, and the results were statistically analyzed.


RESULTS
Significant difference was observed among the total drug release rate in vitro, in vivo and through the roots of extracted teeth (P < 0.01). There was no statistically significant difference between the release test in vivo and through the roots of extracted teeth in vitro (P > 0.05).


CONCLUSIONS
The method of using extracted teeth and the controlled release medium at 37 degrees C, pH7.4 was close to the situation in vivo, and it was an effective method to measure the drug release rate of the root canal disinfection controlled-release delivery system.
Wang
Z
Z
Department of Stomatology, Shangdong Medical University.
Wang
D
D
Gao
J
J
Zhang
W
W
D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005069:Evaluation Studies as Topic; D006801:Humans; D066298:In Vitro Techniques; D008795:Metronidazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012390:Root Canal Therapy; D012995:Solubility
D000891:Anti-Infective Agents, Local; D008795:Metronidazole