[Study on p53 gene expression following transient ischemia in the gerbil].
OBJECTIVE
To study the expression of p53 gene after transient ischemia in the gerbil.


METHODS
Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil.


RESULTS
The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05).


CONCLUSIONS
The high level expression of p53 might induce neuronal apoptosis after ischemia.
Gu
W P
WP
Institute of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Yang
Q D
QD
Xie
G J
GJ
D000818:Animals; D017209:Apoptosis; D016158:Genes, p53; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000235:genetics* / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D015427:Reperfusion Injury / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53