[Effects of para-aminobenzoic acid (PABA) on growth of Lactobacillus acidophilus].
OBJECTIVE
The aim of this study is to examine effects of para-aminobenzoic acid (PABA) on the growth of Lactobacillus acidophilus (L. acidophilus).


METHODS
Different concentrations of PABA (10(-10)-10(-3) g/L) were separately transferred to the modified Carlsson medium. L. acidophilus (ATCC4356) grew in these Carlsson media. All cultures were incubated at 37 degrees C anaerobically in atmosphere of 80% of nitrogen, 10% of hydrogen, and 10% of carbon dioxide for 48 hours. Absorbance values (lambda = 540 nm) of bacterial suspensions were measured using a spectrometer (UV-1601). Colony forming units (CFU) were obtained by growing L. acidophilus in Carlsson media with different concentration of PABA (10(-10)-10(-3) g/L).


RESULTS
Different concentrations of PABA (10(-10)-10(-4) g/L) had different stimulating effects on the growth of L. acidophilus (P < 0.05). But stimulating effects declined, when PABA concentration was 10(-5) g/L, and when the concentration of PABA reached 10(-3) g/L, the stimulating effect disappeared.


CONCLUSIONS
This study indicates PABA stimulates the growth of L. acidophilus, and PABA can promote growth of L. acidophilus.
Guo
B
B
College of Stomatology, West China University of Medical Sciences.
Zhou
X
X
Xiao
X
X
Li
J
J
Li
L
L
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000254:growth & development; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid