title: Common HLA-B8-DR3 haplotype in Northern India is different from that found in Europe.
abstract: The aim of this study was to determine whether a common diabetic haplotype, including human leukocyte antigen (HLA)-B8 and HLA-DR3, in Northern India is the same haplotype as the European HLA-B8-DR3 haplotype. DNA samples from Northern Indian subjects selected on the basis of HLA-B8 and HLA-DR3 were tested for microsatellite and single nucleotide polymorphism alleles throughout the major histocompatibility complex (MHC). It was found that the Indian samples represent a conserved haplotype in which all alleles were shared by Indian subjects with HLA-B8 and HLA-DR3, but were different to those that are characteristic of the European 8.1 ancestral haplotype. The Indian and European haplotypes share HLA-B*0801, HLA-DRB1*0301 and HLA-DQB1*02 but differ for subtypes of HLA-Cw*07 and HLA-DRB3 and all central MHC alleles tested. In contrast, Indian subjects selected on the basis of HLA-B58 ( 1-17) and HLA-DR3 shared the same alleles at other MHC loci as have been described in the common Chinese haplotype with HLA-B58/17 and HLA-DR3. A third haplotype, HLA-B50/21 and HLA-DR3, was also found to be highly conserved but shares little in common with the other two HLA-DR3-containing Indian haplotypes.
authors.affiliation: Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, WA, Australia. campbell.witt@health.wa.gov.au
authors.forename: C S
authors.initials: CS
authors.lastname: Witt
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: G
authors.initials: G
authors.lastname: Kaur
authors.forename: K
authors.initials: K
authors.lastname: Cheong
authors.forename: U
authors.initials: U
authors.lastname: Kanga
authors.forename: D
authors.initials: D
authors.lastname: Sayer
authors.forename: F
authors.initials: F
authors.lastname: Christiansen
authors.forename: N K
authors.initials: NK
authors.lastname: Mehra
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology* / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D015795:HLA-B8 Antigen / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D018895:Microsatellite Repeats; D012307:Risk Factors
chemical_list: D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen