[The effect of rIFN alpha-2b on mice NK cell activity].
OBJECTIVE
This animal experiment was made to study the effect of the recombined interferon alpha-2b(rIFN alpha-2b) on natural killer cells activity of mice spleen in vivo, and by way of this, to test the activity of rIFN alpha-2b.


METHODS
BALB/c mice were given rIFN alpha-2b subcutaneously. The inhibiting 3H-TdR intaking method was used to test the NK activity of spleen cells of BALB/c mice.


RESULTS
The NK cell activity levels of the high-dose group, the mid-dose group and the low-dose group were 65.19 +/- 17.56, 44.19 +/- 14.30 and 35.46 +/- 17.49, respectively.


CONCLUSIONS
rIFN a-2b can enhance NK cells activity observably and its effect is dose dependent.
Zhang
P
P
Department of Immunology, WCUMS, Chengdu 610041, China.
Wei
D
D
Wang
R
R
Zhao
Z
Z
Wang
X
X
Cai
M
M
D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D005260:Female; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D011994:Recombinant Proteins; D013154:Spleen / Q000276:immunology
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins