Gene targeting in immunology.
Transgenics and gene targeting by homologous recombination provide an ideal opportunity to delineate immune functions of specific genes. These gene knockout mice are powerful tools to understand complex mechanism of immune system and molecular processes underlying autoimmune diseases and immunodeficiencies. Availability of an increased pool of genetically manipulated mice will provide a basic foundation for developing of novel strategies to treat immunological diseases.
Totey
S M
SM
Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Kulkarni
A B
AB
D000818:Animals; D018390:Gene Targeting; D005822:Genetic Vectors; D006801:Humans; D007107:Immune System; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D011995:Recombination, Genetic