Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma.
A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiety and impatience. These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system.
Wirtz
Paul W
PW
Department of Neurology, J3R-166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands. pwwirtz@lumc.nl
Sillevis Smitt
Peter A E
PA
Hoff
Jorrit I
JI
de Leeuw
Bertie
B
Lammers
Gert Jan
GJ
van Duinen
Sjoerd G
SG
Verschuuren
Jan J
JJ
D000368:Aged; D000912:Antibodies, Neoplasm / Q000096:biosynthesis / Q000097:blood*; D000951:Antigens, Neoplasm / Q000276:immunology*; D018567:Breast Neoplasms, Male / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D016601:RNA-Binding Proteins
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins