Contribution of classic photoreceptors to entrainment.
The ability to phase shift and entrain in response to light is spared in retinally degenerate mice (rd/rd). In the present work, fewer retinally degenerate C57BL/6 mice than wildtypes entrained in dim lights, suggesting that rods and/or cones contribute toward entrainment even though they are not necessary. Thresholds for entrainment appear to be a more sensitive test of deficits in entrainment than phase shifts in response to light pulses.
Mrosovsky
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Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada. mro@zoo.utoronto.ca
D000818:Animals; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000502:physiology; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000502:physiology*; D012162:Retinal Degeneration / Q000235:genetics / Q000503:physiopathology*; D014785:Vision, Ocular / Q000502:physiology