title: 55 cases of allergic reactions to hair dye: a descriptive, consumer complaint-based study.
abstract: Severe facial and scalp dermatitis following the use of permanent hair dyes has been reported in several cases. Para-phenylenediamine (PPD) is known as a potent contact allergen, and PPD is allowed in hair dye at a concentration of 6%. Hair dye reactions are usually diagnosed by the patients themselves, and adverse reactions to hair dye may not necessarily be recorded by the health care system, unless the reactions are especially severe. Based on this assumption, we suspected that hair dye dermatitis was occurring more frequently than reported in the literature. Consumer complaint-based data were obtained by advertising for persons with adverse reactions to hair dye. Among those responding to the advertisement, 55 cases of severe, acute allergic contact dermatitis were identified. The main symptoms were severe oedema of the face, scalp and ears, and clinically this was often mistaken for angio-oedema. The 55 cases comprised a total of 75 visits to the health service and 5 admissions to hospital. 18 persons had sick leave, which supports the impression of very severe dermatitis reactions. 60% were treated with antihistamine, while 52% were treated with corticosteroids. 29% of the cases were patch tested and all were found positive to PPD. Our data presented here clearly show that PPD and its derivatives in hair dye at the present concentrations presents a significant health risk for the population. Furthermore, the severe acute allergic skin reactions are often misdiagnosed in the health care system. The frequency of allergic contact dermatitis resulting from hair dye is likely to be underestimated. New methods to survey the frequency of adverse reactions should be considered.
authors.affiliation: The National Allergy Research Centre for Consumer Products, Department of Dermatology, University of Copenhagen, Gentofte Hospital, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Søsted
authors.forename: T
authors.initials: T
authors.lastname: Agner
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: T
authors.initials: T
authors.lastname: Menné
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000485:Allergens / Q000009:adverse effects*; D003718:Denmark / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010655:Phenylenediamines / Q000009:adverse effects; D012536:Scalp Dermatoses / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000485:Allergens; D006203:Hair Preparations; D010655:Phenylenediamines; C029728:4-phenylenediamine