title: Novel one-pot synthesis of 3-amino-1-alkenylphophonates by addition of imines to alkynylphosphonate titanium(II) complexes.
abstract: [reaction: see text] A new method of synthesis of 3-amino-1-alkenylphosphonates is described. It involves the addition of imines to the alkynylphosphonate titanium(II) complexes 2, which are prepared in situ from 1-alkynylphosphonates and Ti(O-i-Pr)(4)/2 equiv of i-PrMgCl. Compounds 4a-i were obtained regio- and stereoselectivily in high yields.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University in Jerusalem, Jerusalem 91120, Israel.
authors.forename: Abed Al Aziz
authors.initials: AA
authors.lastname: Al Quntar
authors.forename: Valery M
authors.initials: VM
authors.lastname: Dembitsky
authors.forename: Morris
authors.initials: M
authors.lastname: Srebnik