[Therapeutic effect of gamma-ray stereotactic radiotherapy on brain metastases].
OBJECTIVE
To evaluate the therapeutic effects of gamma-ray stereotactic radiotherapy (SRT) plus whole brain irradiation and radiotherapy alone in brain metastases.


METHODS
Forty-three patients with brain metastases were treated by SRT plus whole brain irradiation and 50 patients were treated by routine radiotherapy. SRT was given with the dosage of 15-27 Gy, and whole brain irradiation was given with the dosage of 30-40 Gy.


RESULTS
One-year survival rate, median survival period, and tumor local control rate in SRT plus whole brain irradiation group were higher or longer than those in the routine radiotherapy group (P < 0.01). Mortality in SRT plus whole brain irradiation group was lower than that in the routine radiotherapy group (P < 0.05).


CONCLUSIONS
The therapeutic effect of SRT plus whole brain irradiation on brain metastasis of cancer is superior to the routine radiotherapy.
Wei
R
R
Department of Radiation Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Ma
Z M
ZM
Yuan
J
J
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D016371:Cranial Irradiation; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D015996:Survival Rate