title: A herd-level analysis of risk factors for antibodies to Sarcocystis neurona in Michigan equids.
abstract: Equine protozoal myeloencephalitis (EPM) is a neurological disease of horses and ponies caused by infection of the central nervous system with the protozoan parasite Sarcocystis neurona. A herd-level analysis of a cross-sectional study of serum antibodies to S. neurona in Michigan equids was conducted, using data collected in 1997 for study that included 1121 equids from 98 Michigan horse farms. Our objective was to identify specific herd-level risk factors associated with seropositivity. We tested associations between herd seroprevalence and various farm-management practices (including feed-storage methods and wildlife control). Multivariable models were developed for three strata based on relative opossum abundance (opossum districts). Herd seroprevalence ranged from 0 to 100% (median=57%). No risk factor was significantly associated with herd seroprevalence at P< or = 0.05 in all opossum districts. Our results suggest that equids living in areas with large opossum populations might be infected with S. neurona from multiple sources.
authors.affiliation: College of Veterinary Medicine, Population Medicine Center, A-109 Veterinary Medical Center, Michigan State University, East Lansing, MI 48824-1314, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Rossano
authors.forename: J B
authors.initials: JB
authors.lastname: Kaneene
authors.forename: J V
authors.initials: JV
authors.lastname: Marteniuk
authors.forename: B D
authors.initials: BD
authors.lastname: Banks
authors.forename: H C
authors.initials: HC
authors.lastname: Schott
authors.forename: L S
authors.initials: LS
authors.lastname: Mansfield
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000302:isolation & purification*; D020808:Central Nervous System Protozoal Infections / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D003430:Cross-Sectional Studies; D004197:Disease Reservoirs / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology*; D006736:Horses / Q000276:immunology / Q000469:parasitology*; D008297:Male; D008824:Michigan / Q000453:epidemiology; D009893:Opossums; D012307:Risk Factors; D012522:Sarcocystis / Q000276:immunology*; D012523:Sarcocystosis / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D016036:Seroepidemiologic Studies
chemical_list: D000913:Antibodies, Protozoan