title: Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline.
abstract: The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline extracted from Uncaria rhynchophylla Miq Jacks were reviewed. The alkaloids mainly act on cardiovascular system and central nervous system including the hypotension, brachycardia, antiarrhythmia, and protection of cerebral ischemia and sedation. The active mechanisms were related to blocking of calcium channel, opening of potassium channel, and regulating of nerve transmitters transport and metabolism, etc.
authors.affiliation: Department of Pharmacology, Zunyi Medical College, 563003, China. jsshi@zmc.gz.cn
authors.forename: Jing-Shan
authors.initials: JS
authors.lastname: Shi
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: Yu
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Chen
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Xu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006801:Humans; D026121:Indole Alkaloids; D018696:Neuroprotective Agents / Q000494:pharmacology; D000078183:Oxindoles; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013237:Stereoisomerism; D032070:Uncaria / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D026121:Indole Alkaloids; D018696:Neuroprotective Agents; D000078183:Oxindoles; D010975:Platelet Aggregation Inhibitors; C052714:rhyncophylline