Chlamydia trachomatis infection in women with CIN and invasive uterine cervix cancer. Significance of hormonal status.
In women with CIN at fertile age and those over 50 years of age, EGFR expression is lower in the presence of Chlamydia trachomatis (Cht) infection. In all Cht infected women over 50 years of age expression of Ki 67 is higher; the increase is significant among women with invasive carcinoma. In these groups of women with CIN and invasive carcinoma TGF-alpha expression is insignificantly augmented. Chronic Cht infection is associated with cervical hypertrophy.
Markowska
J
J
Holy Family Clinic, Poznan, Poland.
Fischer
N
N
Fischer
Z
Z
Warchoł
J B
JB
D000328:Adult; D000367:Age Factors; D002690:Chlamydia Infections / Q000150:complications / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D017931:DNA Primers; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006728:Hormones; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D016211:Transforming Growth Factor alpha / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000382:microbiology* / Q000473:pathology
D017931:DNA Primers; D006728:Hormones; D019394:Ki-67 Antigen; D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors