Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.
It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
Massey
P V
PV
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, Bristol, UK. p.v.massey@bris.ac.uk
Warburton
E C
EC
Wynick
D
D
Brown
M W
MW
Bashir
Z I
ZI
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D019004:Galanin / Q000235:genetics / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D036881:Long-Term Synaptic Depression; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000502:physiology*; D020534:Parahippocampal Gyrus / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D013028:Space Perception / Q000502:physiology
D018679:Cholinergic Agonists; D019004:Galanin; D002217:Carbachol