Adaptation to heat limits stress-induced activation of caspases in the thymus.
We demonstrated selective activation of caspases in the thymus during heat shock, i.e. primary activation of initiator caspase 9 (but not caspase 8) and effector caspase 3 (but not caspase 6). Preadaptation to heat improved animal survival after heat shock and reduced heat shock-induced activation of both initiator and effector caspases. Hence, adaptation to heat produced an antiapoptotic effect, which was not selective towards receptor-dependent or mitochondrial pathway of the caspase cascade activation.
Kruglov
S V
SV
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Baida
L A
LA
Pshennikova
M G
MG
Larionov
N P
NP
Manukhina
E B
EB
Malyshev
I Yu
IY
D000222:Adaptation, Physiological; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D002457:Cell Extracts; D004789:Enzyme Activation; D006358:Hot Temperature; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000201:enzymology*; D013997:Time Factors
D002457:Cell Extracts; D020169:Caspases