Allele frequency determination of publicly available cSNPs in the Korean population.
OBJECTIVE
As a first step toward the construction of a single-nucleotide polymorphism (SNP) database of the Korean population, the authors determined the allele frequencies of 406 cSNPs selected from the public database.


METHODS
A pooled DNA sequencing approach was used to determine the allele frequencies of 406 cSNPs selected from 120 genes in 24 individuals.


RESULTS
Of 406 cSNPs, 53% were monomorphic in the Korean samples. Among tested SNPs, 292 SNPs (72%) were uncommon (minor allele < 20%) and 114 SNPs (28%) were common (minor allele > or = 20%) in our population.


CONCLUSIONS
An extensive SNP characterization would be necessary, and the ethnic and population-based differences should be considered in the selection of SNPs for the study of complex diseases with association mapping methods.
Lee
Seong-Gene
SG
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Yoon
Yongsook
Y
Hong
Sunghee
S
Yoo
Jieun
J
Yang
Insil
I
Song
Kyuyoung
K
D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers