title: [Fractionated stereotactically guided radiotherapy for pharmacoresistant epilepsy].
abstract: OBJECTIVE
  This prospective study evaluated the efficiency of fractionated stereotactically guided radiotherapy as a treatment of pharmacoresistant temporal lobe epilepsy.
  
  
  METHODS
  Inclusion criteria were patients aged between 17 and 65 years with one-sided temporally located focus, without sufficient epilepsy control by antiepileptic drugs or neurosurgery. Between 1997 and 1999, two groups of six patients each were treated with 21 Gy (7 times 3 Gy) and 30 Gy (15 times 2 Gy). Study end points were seizure frequency, intensity, seizure length and neuropsychological parameters.
  
  
  RESULTS
  All patients experienced a marked reduction in seizure frequency. The mean reduction of seizures was 37% (range 9-77%, i. e. seizures reduced from a monthly mean number of 11.75 to 7.52) at 18 months following radiation treatment and 46% (23-94%, i. e. 0.2-23 seizures per month) during the whole follow-up time. Seizure length was reduced in five out of eleven patients and intensity of seizures in seven out of eleven patients.
  
  
  CONCLUSIONS
  Radiotherapy was identified as safe and effective for pharmacoresistant epilepsy since a very good reduction of seizure frequency was observed. It is no substitute for regular use of antiepileptic drugs, but means an appropriate alternative for patients with contraindication against neurosurgery or insufficient seizure reduction after neurosurgery.
authors.affiliation: Klinik und Poliklinik für Strahlentherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. gerd.grabenbauer@strahlen.med.uni-erlangen.de
authors.forename: Gerhard G
authors.initials: GG
authors.lastname: Grabenbauer
authors.forename: Christian
authors.initials: C
authors.lastname: Reinhold
authors.forename: Frank
authors.initials: F
authors.lastname: Kerling
authors.forename: Reinhold G
authors.initials: RG
authors.lastname: Mueller
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lambrecht
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Pauli
authors.forename: Oliver
authors.initials: O
authors.lastname: Ganslandt
authors.forename: Hermann
authors.initials: H
authors.lastname: Stefan
authors.forename: Rolf
authors.initials: R
authors.lastname: Sauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019583:Dose Fractionation, Radiation; D004351:Drug Resistance; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D016896:Treatment Outcome