Pigment epithelium-derived factor (PEDF), a serpin with potent anti-angiogenic and neurite outgrowth-promoting properties.
Pigment epithelium-derived factor is a member of the serpin superfamily of proteins, but one that lacks inhibitory properties against either serine or cysteine proteinases. Nevertheless it possesses a number of physiological properties that make it a potentially important protein in regulation of angiogenesis, in neuronal cell survival and in protection of neurons from neurotoxic agents. It is also a protein that is highly up-regulated in the G0 phase of early-passage cells compared with rapidly proliferating cells or senescent cells, and so is also linked to both the cell cycle and cell senescence. The determination of a high resolution X-ray crystal structure of native PEDF provides insight into regions of the protein that may be involved in one or more of these functions.
Gettins
Peter G W
PG
Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Simonovic
Miljan
M
Volz
Karl
K
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D005136:Eye Proteins; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D009414:Nerve Growth Factors; D009420:Nervous System / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D016501:Neurites / Q000187:drug effects*; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology*; D015843:Serpins / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology*; D000099174:Pigment Epithelium-Derived Factor
D020533:Angiogenesis Inhibitors; D005136:Eye Proteins; D009414:Nerve Growth Factors; D011506:Proteins; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor