title: [Separation and determination of the ingredients of cold medicines by capillary electrophoresis with amperometric detection].
abstract: Determination and separation of three ingredients--chlorphenamine maleate, acetaminophen and vitamin C in cold medicines by capillary electrophoresis with amperometric detection were carried out. The effects of detection potential and organic modifier were extensively investigated. Separation efficiency could be improved by adding 1, 2-propanediol into buffer. On optimizing condition, chlorphenamine maleate, acetaminophen and vitamin C were separated satisfactorily and eluted within 12 min. The detection limits were 0.02, 0.08 and 0.01 mg/L respectively. The ingredients in several cold medicines were detected successfully. The recoveries of the samples were 94.2%-102.8%. The method is simple, rapid and highly reliable for routine analysis.
authors.affiliation: School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, China.
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Mo
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000082:Acetaminophen / Q000032:analysis / Q000302:isolation & purification*; D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000302:isolation & purification; D018926:Anti-Allergic Agents / Q000032:analysis / Q000302:isolation & purification; D001205:Ascorbic Acid / Q000032:analysis / Q000302:isolation & purification*; D002744:Chlorpheniramine / Q000032:analysis / Q000302:isolation & purification*; D004339:Drug Compounding; D019075:Electrophoresis, Capillary / Q000379:methods*
chemical_list: D018712:Analgesics, Non-Narcotic; D018926:Anti-Allergic Agents; D000082:Acetaminophen; D002744:Chlorpheniramine; D001205:Ascorbic Acid