title: Modulation of EGF receptor autophosphorylation by alpha-hemolysin of Staphylococcus aureus via protein tyrosine phosphatase.
abstract: In the presence of assembled alpha-hemolysin (alpha-HL) of Staphylococcus aureus, the epidermal growth factor receptor (EGFr) is rapidly dephosphorylated. Several obvious possibilities that otherwise would have contributed to the dephosphorylation were ruled out. Instead, an elevation in the activity of a protein tyrosine phosphatase appears to be responsible for the observed loss of phosphorylation signal of EGFr. For this dephosphorylation, the assembly of alpha-HL is necessary while lytic pore formation is not required. In summary, the EGFr is unable to retain its phosphorylation signal in the presence of alpha-HL and the process is irreversible.
authors.affiliation: National Center for Cell Science, Ganeshkind Road, Pune 411 007, India.
authors.forename: Sharma
authors.initials: S
authors.lastname: Vandana
authors.forename: Sangha
authors.initials: S
authors.lastname: Navneet
authors.forename: Kaur
authors.initials: K
authors.lastname: Surinder
authors.forename: M V
authors.initials: MV
authors.lastname: Krishnasastry
mesh_terms: D019943:Amino Acid Substitution; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D011485:Protein Binding / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000201:enzymology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D010446:Peptide Fragments; C021091:staphylococcal alpha-toxin; D066246:ErbB Receptors; D017027:Protein Tyrosine Phosphatases