title: A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas.
abstract: Increasing clinical and pathological evidence suggests that malignant fibrous histiocytomas (MFH) comprise a heterogeneous tumor group. In a series of 108 MFH tested by comparative genomic hybridization, we found in 22 tumors high-level coamplification of the 12q14 approximately q15 chromosome region with other loci, a genetics strongly reminiscent of what has been observed for well-differentiated liposarcomas. Nevertheless, these MFH differ from liposarcomas by a high recurrence of coamplified partners because coamplified loci were seen at 1p32 in nine cases, 6q23 in seven cases, and 12q24 in six cases. The same recurrence was observed in a series of dedifferentiated liposarcomas, but not in a series of well-differentiated liposarcomas. These observations demonstrate that a subgroup of MFH share a genetic partner very similar to that observed in liposarcomas, and suggest that the undifferentiated status of these tumors is closely related to the amplifications of specific chromosome loci.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U509, Curie Institute, cedex, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chibon
authors.forename: Odette
authors.initials: O
authors.lastname: Mariani
authors.forename: Josette
authors.initials: J
authors.lastname: Derré
authors.forename: Sébastien
authors.initials: S
authors.lastname: Malinge
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Coindre
authors.forename: Louis
authors.initials: L
authors.lastname: Guillou
authors.forename: Réal
authors.initials: R
authors.lastname: Lagacé
authors.forename: Alain
authors.initials: A
authors.lastname: Aurias
mesh_terms: D022981:Allelic Imbalance; D002454:Cell Differentiation; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002896:Chromosomes, Human, Pair 6; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization