title: Hepcidin, a new iron regulatory peptide.
abstract: Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction. Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis.
authors.affiliation: Département de génétique, développement et Pathologie Moléculaire, Institut Cochin, Faculté de Médecine Cochin-Port Royal, 24 rue du Fg St Jacques, 75014 Paris, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Nicolas
authors.forename: Lydie
authors.initials: L
authors.lastname: Viatte
authors.forename: Myriam
authors.initials: M
authors.lastname: Bennoun
authors.forename: Carole
authors.initials: C
authors.lastname: Beaumont
authors.forename: Axel
authors.initials: A
authors.lastname: Kahn
authors.forename: Sophie
authors.initials: S
authors.lastname: Vaulont
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D004921:Erythropoietin / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D064451:Hepcidins; D007501:Iron / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data
chemical_list: D023181:Antimicrobial Cationic Peptides; C579599:Hamp protein, mouse; D064451:Hepcidins; D004921:Erythropoietin; D007501:Iron