title: Case of postradiation osteosarcoma with a short latency period of 3 years.
abstract: Osteosarcoma is one of the neoplasms that may occur following exposure to radiation. A case of osteosarcoma arising in the craniofacial bone with a short latency period of 3 years after radiotherapy for maxillary squamous cell carcinoma is described. A 64-year-old-man underwent right partial maxillectomy and chemoradiotherapy due to squamous cell carcinoma of his right maxillary sinus. Histologically, the tumor was composed of moderately differentiated squamous cell carcinoma with a component of spindle cell carcinoma. Three years later, osteosarcoma developed in the craniofacial bone within the irradiation field of the first tumor. Detailed histological examination demonstrated that there was no component of osteosarcoma in the first tumor or squamous cell carcinoma in the second tumor. Radiation-induced osteosarcoma usually occurs after a long latency period of more than 10 years after the radiotherapy. In this case, osteosarcoma was possibly a radiation-induced osteosarcoma with a short latency period of 3 years.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Saga Medical School, Saga, Japan. amatsu@fujita-hu.ac.jp
authors.forename: Atsuji
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Yonemitsu
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Hayashida
authors.forename: Keiko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hajime
authors.initials: H
authors.lastname: Sugihara
authors.forename: Akira
authors.initials: A
authors.lastname: Inokuchi
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005147:Facial Bones / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors