title: Cerebrovascular carbon dioxide reactivity in children anaesthetized with propofol.
abstract: BACKGROUND
  Propofol, by virtue of its favourable pharmacokinetic profile, is suitable for maintenance of anaesthesia by continuous infusion during neurosurgical procedures in adults. It is gaining popularity for use in paediatric patients. To determine the effects of propofol on carbon dioxide cerebrovascular reactivity in children, middle cerebral artery blood flow velocity was measured at different levels of endtidal (PECO2) by transcranial Doppler sonography.
  
  
  METHODS
  Ten ASA I or II children, aged 1-6 years undergoing elective urological surgery were enrolled. Anaesthesia comprized propofol aimed at producing an estimated steady-state serum concentration of 3 microg x ml-1 and a caudal epidural block. PECO2 was adjusted randomly in an increasing or decreasing fashion between 3.3, 5.2 and 7.2 kPa (25, 40 and 55 mmHg) with an exogenous source of CO2 while maintaining ventilation parameters constant.
  
  
  RESULTS
  Cerebral blood flow velocity increased as PECO2 increased from 3.3 to 5.2 kPa (25-40 mmHg) (P < 0.001) and from 5.2 to 7.2 kPa (40-55 mmHg) (P < 0.001). Mean heart rate and blood pressure did not change significantly.
  
  
  CONCLUSIONS
  This study demonstrates that cerebrovascular CO2 reactivity is maintained over PECO2 values of 3.3, 5.2 and 7.2 kPa (25, 40 and 55 mmHg) in healthy children anaesthetized with propofol.
authors.affiliation: Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Karsli
authors.forename: Igor
authors.initials: I
authors.lastname: Luginbuehl
authors.forename: Marc
authors.initials: M
authors.lastname: Farrar
authors.forename: Bruno
authors.initials: B
authors.lastname: Bissonnette
mesh_terms: D018686:Anesthetics, Intravenous; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D015742:Propofol; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D015742:Propofol