title: Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
abstract: We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
authors.affiliation: Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK.
authors.forename: Georg
authors.initials: G
authors.lastname: Lautscham
authors.forename: Tracey
authors.initials: T
authors.lastname: Haigh
authors.forename: Sabine
authors.initials: S
authors.lastname: Mayrhofer
authors.forename: Graham
authors.initials: G
authors.lastname: Taylor
authors.forename: Debbie
authors.initials: D
authors.lastname: Croom-Carter
authors.forename: Alison
authors.initials: A
authors.lastname: Leese
authors.forename: Stephan
authors.initials: S
authors.lastname: Gadola
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cerundolo
authors.forename: Alan
authors.initials: A
authors.lastname: Rickinson
authors.forename: Neil
authors.initials: N
authors.lastname: Blake
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D018984:Epitopes, T-Lymphocyte; D015789:HLA-A2 Antigen; C073119:TAP1 protein, human; C071313:LMP-2 protein; D003546:Cysteine Endopeptidases