title: [Structure of the adrenal gland in rat strain with hereditary stress-induced arterial hypertension nursed by Wistar dams].
abstract: The comparative investigation of the adrenal structure in two groups of rats of Inherited Stress-Induced Arterial Hypertension (ISIAH) strain was conducted. The animals of the first group were nursed by normotensive Wistar rats, while those of the second (control) group were reared by their own mothers. The volume of the adrenal medulla in rats of the first group was found to exceed that in the second group. In the adrenal zona glomerulosa and zona fasciculata of 3-week-old rats of the first group parenchymal-stromal ratio and the average volume of adrenocorticocytes were lower than those in the animals of the second group. This was accompanied by a decrease in mitochondrial volume density and accumulation of lipid droplets in the cytoplasm, indicating a reduction of hormone-producing activity of endocrinocytes in the animals the first group as compared to controls. By 6 month of age, arterial pressure and quantitative parameters of adrenal medulla and cortex in the animals the first group were..... as compared to those in the second group. It is suggested that the nursing of ISIAH rat pups by normotensive Wistar dams had modulating effect on the adrenal structure and therefore on arterial hypertension development.
authors.affiliation: Laboratory of Electron Microscopy and Laboratory of Pathophysiology, Institute of Physiology, Laboratory of Evolutionary Animal Genetics, Institute of Cytology, Siberian Section of RAMS, Novosibirsk.
authors.forename: I I
authors.initials: II
authors.lastname: Buzueva
authors.forename: M D
authors.initials: MD
authors.lastname: Shmerling
authors.forename: E E
authors.initials: EE
authors.lastname: Filiushina
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
authors.forename: G S
authors.initials: GS
authors.lastname: Iakobson
mesh_terms: D000302:Adrenal Cortex / Q000473:pathology / Q000648:ultrastructure*; D000818:Animals; D000833:Animals, Suckling; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D007774:Lactation / Q000502:physiology; D008854:Microscopy, Electron; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000150:complications*; D015383:Zona Fasciculata / Q000473:pathology / Q000648:ultrastructure; D015384:Zona Glomerulosa / Q000473:pathology / Q000648:ultrastructure