title: [The alterations in vasoactive intestinal polypeptide-immune reaction positive neurons of cerebral tissues in epileptic rats induced by penicillin].
abstract: To further explore the action of vasoactive intestinal polypeptide(VIP) in epileptogenesis, we made an immunocytochemical analysis and observed the alterations in VIP-energic neurons of the cerebral cortex, hippocampus and amygdaloid in rats. The animals were divided into three groups: the control, the epileptic group in which seizure was induced by injected Penicillin(PNC) intraperitoneally, and the nimodipline(NIM) group in which seizure was impressed by giving PNC after NIM, a dihydropyridine calcium entry blocker, was injected. The results showed that the number of neurons of epileptic group increased, compared with that of control group (P < 0.01), the neuronic number of the epileptic group was higher than that of the NIM group(P < 0.01), whereas there was no significant difference in neuronic number between the control group and the NIM group(P > 0.05). These suggest that VIP and Ca2+ participate in the process of epileptogenesis.
authors.affiliation: Department of Neurology, First Affiliated Hospital, WCUMS, Chengdu, 610041.
authors.forename: X
authors.initials: X
authors.lastname: Zou
authors.forename: X
authors.initials: X
authors.lastname: Ruan
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D010406:Penicillins; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
chemical_list: D010406:Penicillins; D014660:Vasoactive Intestinal Peptide; D002118:Calcium