title: A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13).
abstract: We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.
authors.affiliation: Department of Internal Medicine II, Graduate School of Medicine and Dentistry, Okayama University, Japan. kkoji@m.ehime-u.ac.jp
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Kaneda
authors.forename: Chikamasa
authors.initials: C
authors.lastname: Yoshida
authors.forename: Hirokata
authors.initials: H
authors.lastname: Dansako
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Fujii
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Yano
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shinagawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujita
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D015321:Gene Rearrangement; D051548:Histone Acetyltransferases; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014178:Translocation, Genetic
chemical_list: D002352:Carrier Proteins; D029701:Saccharomyces cerevisiae Proteins; C020723:citrate-binding transport protein; D003561:Cytarabine; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D015255:Idarubicin