title: [Use of Azopiram for rapid diagnosis of epithelial tumors of the urinary bladder (experimental data)].
abstract: Correlation of development of tumor pathology and macro- and microhematuria was investigated in the experiments using 50 male rats with N-butyl-N-(4-hydroxybutyl)-nitrosoamine-induced tumors of the urinary bladder. Our highly-sensitive agent Azopiram was employed to monitor hematuria. Microhematuria, which subsequently developed into macrohematuria as tumor matured and turned malignant, was identified as early as at such incipient neoplastic changes as focal hyperplasia of the urothelium and micropapillomatosis. The test can be used outside clinic as a measure of self-control in recurrent cancer of the urinary bladder.
authors.affiliation: N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: G B
authors.initials: GB
authors.lastname: Pliss
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Al'-Shurki
authors.forename: A S
authors.initials: AS
authors.lastname: Mel'nikov
authors.forename: M G
authors.initials: MG
authors.lastname: Pliss
mesh_terms: D000632:Aminopyrine; D000814:Aniline Compounds; D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002273:Carcinogens; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D006417:Hematuria / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*
chemical_list: D000814:Aniline Compounds; D002273:Carcinogens; D000632:Aminopyrine; C057507:azopyram; D002085:Butylhydroxybutylnitrosamine