title: Antiphospholipid antibody syndrome complicated by Grave's disease.
abstract: The report describes a woman with primary antiphospholipid antibody syndrome complicated with Grave's disease. Developing symptoms included a small cutaneous nodule on her finger and subsequently ecchymotic purpura on the cheeks, ears, buttocks and lower legs. Histological examinations showed thrombosed vessels in the dermis without or with hemorrhage, respectively. Laboratory investigation revealed positive lupus anticoagulant and immunogenic hyperthyroidism due to Grave's disease. There is a close relationship between the cutaneous manifestation of antiphospholipid antibody syndrome and the activities of Grave's disease and a possible link of antiphospholipid antibody syndrome with Grave's disease was suggested both by the etiology of the disease as well as the disease activity.
authors.affiliation: Department of Dermatology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011256:Pregnancy Outcome; D018570:Risk Assessment; D012720:Severity of Illness Index; D013960:Thyroid Function Tests
chemical_list: D017152:Antibodies, Antiphospholipid