title: [Medico-economic evaluation of abciximab].
abstract: Abciximab (RéoPro) is a chimeric monoclonal antibody directed against platelet glycoprotein IIb-IIIa. It reduces the frequency of major cardiac ischaemic events after percutaneous transluminal coronary angioplasty (PTCA). This treatment is more expensive than the commonly used treatment (aspirin and heparin). However, a treatment can only be validly assessed in term of its cost-benefit ratio. The authors present the results of a medico-economic evaluation of abciximab in the French institutional context, based on the three-year clinical results of the EPIC study (Evaluation of abciximab for the Prevention of Ischemic Complications). The efficacy of treatment was expressed by means of two quantitative indicators: the number of patients with no major ischaemic event (MIE) and the number of years of life without myocardial infarction or revascularization. According to French good practice recommendations for economic evaluation of therapeutic strategies, major ischaemic events were assessed by using the complete cost of the corresponding homogeneous groups of diseases (GHM). Medico-economic evaluation of abciximab showed that the net excess cost per patient for national health insurance was 395 Francs, while the cost of the product is 5,300 Francs. The incremental cost per additional patient with no major ischaemic event is 6,585 Francs and the incremental cost per additional year of life without myocardial infarction or revascularization is 2,469 F. From a public health point of view, abciximab administered by bolus injection plus a 12-hour infusion, presents a good cost-effectiveness ratio in the prevention of cardiac ischaemic complications in high-risk patients after PTCA.
authors.affiliation: Université Paris Dauphine, Paris, CLP Santé, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Le Pen
authors.forename: J
authors.initials: J
authors.lastname: Bonastre
authors.forename: P
authors.initials: P
authors.lastname: Pinton
mesh_terms: D000077284:Abciximab; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000191:economics* / Q000494:pharmacology / Q000627:therapeutic use*; D000925:Anticoagulants / Q000191:economics* / Q000494:pharmacology / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D018572:Disease-Free Survival; D016527:Drug Costs / Q000706:statistics & numerical data; D005602:France / Q000453:epidemiology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000191:economics* / Q000494:pharmacology / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D017059:Models, Econometric; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D009313:National Health Programs / Q000191:economics; D010975:Platelet Aggregation Inhibitors / Q000191:economics* / Q000494:pharmacology / Q000627:therapeutic use*; D015980:Public Health Practice / Q000191:economics; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab