title: Photoprotective activity of melanin preparations in human skin exposed to UV irradiation: dependence on previous photoexposure.
abstract: Photoprotective effects of three melanin preparations (from black yeast fungi and Sepia sp.) were studied. These preparations in aqueous solutions (5 g/ml, dark exposure for 7 days) demonstrated high photomodification capacity upon exposure to visible light in doses of up to 1.8 kJ/m2. Preliminary exposure of these solutions to visible light in a dose of 360 kJ/m2 notably decreased the photoprotective effect of melanins during UV exposure of the skin treated with these solutions (at UV dose of 3.4 kJ/m2). This necessitates empirical selection of the dose and storage condition of melanin preparations for attaining the optimal photoprotective effect.
authors.affiliation: SPb-Tekhnologiya Firm, St. Petersburg.
authors.forename: B A
authors.initials: BA
authors.lastname: Paramonov
authors.forename: I I
authors.initials: II
authors.lastname: Turkovskii
authors.forename: I L
authors.initials: IL
authors.lastname: Potokin
authors.forename: N A
authors.initials: NA
authors.lastname: Yurlova
authors.forename: V Yu
authors.initials: VY
authors.lastname: Chebotarev
mesh_terms: D001203:Ascomycota / Q000737:chemistry; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008543:Melanins / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D008543:Melanins; D011837:Radiation-Protective Agents