NO-inhibiting and vasotropic activity of some compounds with thioamidine group.
Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group.
Proskuryakov
S Ya
SY
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia.
Kucherenko
N G
NG
Trishkina
A I
AI
Filimonova
M V
MV
Shevchuk
A G
AG
Shtein
L V
LV
Verkhovskii
Yu G
YG
Konoplyannikov
A G
AG
Mandrugin
A A
AA
Fedoseev
V M
VM
Skvortsov
V G
VG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects; D013045:Species Specificity; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D004731:Endotoxins; D004791:Enzyme Inhibitors; D013843:Thiazines; D013844:Thiazoles; D014662:Vasoconstrictor Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase