[The investigation of bioadhesive property of carbomer 934 by gamma camera in vivo].
To study bioadhesive property of carbomer 934 in dog alimentary tract, carbomer 934 and ethylcellulose were radiolabelled with technetium-99 m. The gastrointestinal emptying rate of these materials was measured by the technique of gamma scintiscan. The results showed that the empty rate of adhesive material (carbomer 934) was remarkably slower in dog alimentary tract compared to nonadhesive material (ethylcellulose). It is concluded that, in dog, the interaction between gastrointestinal mucus layer and adhesive material or nonadhesive material was significantly different. Carbomer 934 had stronger bioadhesive property in vivo than that of ethylcellulose.
Fu
Jie
J
West China School of Pharmacy, Sichuan University, Chengdu 610041.
Sun
Xun
X
Zhang
Zhirong
Z
D000180:Acrylic Resins / Q000493:pharmacokinetics*; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004064:Digestive System / Q000000981:diagnostic imaging; D004285:Dogs; D015902:Gamma Cameras; D005746:Gastric Emptying; D007413:Intestinal Mucosa / Q000378:metabolism; D016719:Radioimmunodetection
D000180:Acrylic Resins; C006903:carbopol 940; C013517:ethyl cellulose; D002482:Cellulose