title: Effects of metabolic control on vitamin E nutritional status in children with type 1 diabetes mellitus.
abstract: OBJECTIVE
  To evaluate the effects of the metabolic control of the insulin-dependent diabetes mellitus (IDDM) on the nutritional status of vitamin E.
  
  
  METHODS
  A total of 47 children with IDDM and a mean age of 11.91+/-1.60 (mean+/-SD) years were studied, matched for age and sex with 16 healthy children (11.75+/-1.83 years). Following the American and British Associations for IDDM, we used a classification of "good", "moderate" or "poor" control of the illness: (a) good control [glycosilated haemoglobin (HbAlc) < or =7%]; (b) moderate control (7%< HbAlc < or =8%); and (c) poor control (HbAlc>8%). Serum concentrations of total cholesterol (CHOL), triglycerides (TG), high-density lipoproteins-cholesterol (HDLc), very low- and low-density lipoproteins cholesterol (VLDLc and LDLc), plasma and erythrocyte vitamin E (Vit Ep and Vit Ee) and plasma vitamin A (Vit Ap) were measured in all children.
  
  
  RESULTS
  The children with "poor" metabolic control of the illness presented significantly higher plasma concentrations of CHOL, LDLc, VLDLc, LDLc/HDLc, (VLDL+LDL)c/HDLc, TG and Vit Ep; higher indices Vit Ep/Vit Ee and Vit Ep/Vit Ap relative to those with a "good" control of the illness. Direct-linear correlations were found between Vit Ep and the percentage of HbAlc and with the markers of atherogenic risk in the IDDM children.
  
  
  CONCLUSIONS
  There is a significant rise in Vit Ep concentrations as metabolic control of the illness worsens, whereas Vit Ee remained unchanged. These results suggest that vitamin E maintains its nutritional status despite a poor control of the IDDM during childhood.
authors.affiliation: Department of Paediatrics, School of Medicine, University of Granada, Avda. de Madrid 11, Granada 18012, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Campoy
authors.forename: R M
authors.initials: RM
authors.lastname: Baena
authors.forename: E
authors.initials: E
authors.lastname: Blanca
authors.forename: C
authors.initials: C
authors.lastname: López-Sabater
authors.forename: J M
authors.initials: JM
authors.lastname: Fernandez-García
authors.forename: M T
authors.initials: MT
authors.lastname: Miranda
authors.forename: J A
authors.initials: JA
authors.lastname: Molina-Font
authors.forename: R
authors.initials: R
authors.lastname: Bayés
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D015415:Biomarkers; D002648:Child; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D015415:Biomarkers; D002784:Cholesterol; D006442:Glycated Hemoglobin; D008074:Lipoproteins; D014280:Triglycerides; D014801:Vitamin A; D014810:Vitamin E