title: Endoscopic laser treatment in pre-malignant and malignant vocal fold epithelial lesions.
abstract: Endoscopic laser treatment was performed in 43 patients with pre-malignant or malignant vocal fold epithelial lesions, 10 were treated with endoscopic laser surgery for dysplasia, 12 for carcinoma in situ (CIS), five for verrucous carcinoma and 16 patients for squamous cell carcinoma (SCC). Thirty-two patients received laser therapy as their first therapy, whereas 11 patients had had previous radiation therapy for laryngeal carcinoma (n = 9) or CIS (n = 2). Recurrence after initial laser therapy necessitating re-treatment (a second laser treatment or radiotherapy) occurred in nine out of 32 patients (28 per cent), thus 23 (72 per cent) were maintained free of disease during the follow-up period. Besides the 32 patients without previous therapy, patients who had already undergone radiation therapy were also included in this study. In this group there were nine patients with SCC, one patient with CIS and one with dysplasia. They all underwent laser therapy. Four were free of disease during follow-up (36 per cent) and seven developed recurrences. Six (58 per cent of all patients with previous radiation therapy) underwent total laryngectomy.
authors.affiliation: Department of Otorhinolaryngology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
authors.forename: E E G
authors.initials: EE
authors.lastname: Remijn
authors.forename: H A M
authors.initials: HA
authors.lastname: Marres
authors.forename: F J A
authors.initials: FJ
authors.lastname: van den Hoogen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000503:physiopathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology / Q000601:surgery*; D018289:Carcinoma, Verrucous / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000601:surgery*; D007828:Laryngoscopy; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D017060:Patient Satisfaction; D011230:Precancerous Conditions / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014827:Vocal Cords / Q000502:physiology / Q000601:surgery*