title: Objective evidence of a high prevalence of renal damage in women with type 2 diabetes by technetium-99m DMSA renal cortex scan findings.
abstract: OBJECTIVE
  To compare control women with men and women with type 2 diabetes mellitus (DM) for the prevalence and type of renal damage due to urinary tract infections (UTIs) using technetium-99m dimercapto-succinic acid (99mTc DMSA) renal scanning. Women with DM have UTIs more often than do women without DM. It is unknown, however, what the prevalence and type of renal damage due to UTI are in these women.
  
  
  METHODS
  Three groups of patients: 28 control women without type 2 DM and a history of UTIs, 25 male patients with type 2 DM but without a history of UTIs, and 103 female patients with type 2 DM underwent 99mTc DMSA renal scan. The 103 women with type 2 DM were separated into three groups: 36 women without a history of UTIs, 34 patients with a history of cystitis only, and 33 with a history of pyelonephritis.
  
  
  RESULTS
  All the control women and male patients with type 2 DM without a history of UTIs had normal 99mTc DMSA renal scan findings. However, 39.8% of women with type 2 DM had abnormal 99mTc DMSA renal scan findings. Women with type 2 DM without a history of UTI had a significantly lower prevalence of abnormal renal scan findings than did those with a history of cystitis only or pyelonephritis. In addition, the prevalence of abnormal renal scan findings was significantly higher in women with type 2 DM with pyelonephritis than in those with a history of cystitis only. Renal scars on 99mTc DMSA renal scans were found in women with type 2 DM and a history of pyelonephritis.
  
  
  CONCLUSIONS
  Compared with control women and men with type 2 DM, women with type 2 DM, especially if they had a history of UTIs, had a significantly higher prevalence of abnormal 99mTc DMSA renal scan findings.
authors.affiliation: Department of Urology, China Medical College Hospital, Taichung, Taiwan.
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Huang
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Cheng-Chun
authors.initials: CC
authors.lastname: Lee
authors.forename: Albert
authors.initials: A
authors.lastname: Kao
authors.forename: Wen-Shen
authors.initials: WS
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging; D007672:Kidney Cortex / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011877:Radionuclide Imaging; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging* / Q000453:epidemiology*
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid