title: A new phenylacetate-bisphosphonate inhibits breast cancer cell growth by proapoptotic and antiangiogenic effects.
abstract: Sodium phenylacetate (NaPa) and some bisphosphonates demonstrated antiproliferative and proapoptotic properties against cancer. We have previously shown that NaPa inhibited cell proliferation of MCF7-ras tumor breast cells both in vitro and in vivo. On the other hand, bisphosphonate activities have only been demonstrated in vitro. Here we evaluated the antitumor effects of a new bisphosphonate, the phenylacetate-bisphosphonate (PaBp), on human breast cancer MCF7 and MCF7-ras cell lines, both in vitro and in vivo. To our knowledge, this is the first report indicating the use of a bisphosphonate derivative as a powerful cytostatic and cytotoxic agent, with proapoptotic and antiangiogenic properties on human breast cancer cells lines, with no animal toxicity.
authors.affiliation: UPRES 2360 Ciblage et Imagerie Fonctionnells de la Progression Tumorale, Université de Médecine Paris-XIII, 74, rue Marcel Cachin, 93017 Bobigny, France.
authors.forename: Malika
authors.initials: M
authors.lastname: Sebbah-Louriki
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Colombo
authors.forename: Driss
authors.initials: D
authors.lastname: el Manouni
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Salzmann
authors.forename: Yves
authors.initials: Y
authors.lastname: Leroux
authors.forename: Gérard Y
authors.initials: GY
authors.lastname: Perret
authors.forename: Michel
authors.initials: M
authors.lastname: Crépin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010648:Phenylacetates / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D010648:Phenylacetates; C471708:phenylacetate-bisphosphonate