Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
As part of a study on antitumor agents from rainforest plants, two new flavanones, buceracidin A (1), 5,2'-dihydroxy-3-methoxy-6,7-(2' ',2' '-dimethylchromene)flavanone, and buceracidin B (2), 5,2'-dihydroxy-6,7-(2' ',2' '-dimethylchromene)flavanone, were isolated together with four known prenylated flavanones, minimiflorin (3), 3-hydroxyminimiflorin (4), 3-methoxyminimiflorin (5), and mundulinol (6), from Bucida buceras. The structures of buceracidins A and B were elucidated from detailed 2D NMR analyses. Among the six flavanones, 3, 5, and 6 were marginally cytotoxic in a human tumor cell line panel.
Hayashi
Ken-Ichiro
K
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA. khlee@unc.edu
Nakanishi
Yuka
Y
Bastow
Kenneth F
KF
Cragg
Gordon
G
Nozaki
Hiroshi
H
Lee
Kuo-Hsiung
KH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001531:Belize; D029764:Combretaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; D005419:Flavonoids; C474701:buceracidin A; C474703:buceracidin B