title: GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.
abstract: GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.
authors.affiliation: University of Michigan, Ann Arbor, MI 48104-1687, USA.
authors.forename: Dorothy M
authors.initials: DM
authors.lastname: Jones-Davis
authors.forename: Robert L
authors.initials: RL
authors.lastname: Macdonald
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D006801:Humans; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A