title: Genetic structure of seven Mexican indigenous populations based on five polymarker loci.
abstract: This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H(T)) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases.
authors.affiliation: Instituto de Investigaciónes Antropologicas, Universidad Nacional Autonoma de Mexico, Mexico DF.
authors.forename: Leonora
authors.initials: L
authors.lastname: Buentello-Malo
authors.forename: Rosenda I
authors.initials: RI
authors.lastname: Peñaloza-Espinosa
authors.forename: Francisco
authors.initials: F
authors.lastname: Loeza
authors.forename: Fabio
authors.initials: F
authors.lastname: Salamanca-Gomez
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Cerda-Flores
mesh_terms: D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers