title: Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.
abstract: Ascaridol is the active principle of the American wormseed Chenopodium anthelminticum L. We isolated ascaridol from a commercial preparation of Chenopodium oil and analyzed its activity against different tumor cell lines in vitro (CCRF-CEM, HL60, MDA-MB-231). Multidrug-resistant (MDR) counterparts of these cell lines express differentially the MDR-conferring ATP-binding cassette transporter genes MDR1, MRP1 and BCRP, respectively. We found that ascaridol exerts antineoplastic activity. The findings of the present investigation are the first hint that ascaridol may be an interesting novel candidate drug for cancer treatment.
authors.affiliation: Virtual Campus Rhineland-Palatinate, Saac Fulda-Allee 3, 55124 Mainz, Germany. efferth@vcrp.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
authors.forename: Armin
authors.initials: A
authors.lastname: Olbrich
authors.forename: Axel
authors.initials: A
authors.lastname: Sauerbrey
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Ross
authors.forename: Erich
authors.initials: E
authors.lastname: Gebhart
authors.forename: Michael
authors.initials: M
authors.lastname: Neugebauer
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D027462:Chenopodium / Q000737:chemistry*; D000081005:Cyclohexane Monoterpenes; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D010545:Peroxides; C043372:ascaridole