title: Autoimmune thyroid disease accompanied by recurring episodes of painful thyroid ameliorated by thyroidectomy.
abstract: A 71-yr-old female initially presented with clinical and biochemical hyperthyroidism with high TSH binding inhibitory immunoglobulin (TBII) and anti-thyroid peroxidase antibody (TPOAb) titers. Histological findings of the thyroid revealed hyperplasia with a focal germinal center, indicating Graves' disease and mild focal chronic thyroiditis. Four episodes of painful and tender thyroid occurred over the next 2 yr accompanied by acute inflammatory reactions. The first episode that developed while the patient was in a hyperthyroid state was soon followed by hypothyroidism associated with further increases in anti-thyroglobulin antibody (TGAb) and TPOAb titers. The subsequent 3 episodes occurred during the hypothyroid state, when the TGAb titer progressively increased with each episode. We performed subtotal thyroidectomy to prevent further episodes. Specimens obtained at thyroidectomy showed that extreme fibrosis had replaced the thyroid parenchyma with collapsed follicles and moderate lymphocyte infiltration. No further episodes occurred after thyroidectomy, and during a 3-yr follow-up period, TBII and thyroid-stimulating antibody (TSAb) disappeared and TGAb and TPOAb titers decreased. This case report provides further evidence supporting the notion that thyroid epithelial destruction progresses during relatively short periods of recurrent painful thyroid and that thyroidectomy helps patients affected by this condition that are unresponsive to other treatment strategies.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan. nori-kon@gray.plata.or.jp
authors.forename: S
authors.initials: S
authors.lastname: Konno
authors.forename: N
authors.initials: N
authors.lastname: Konno
authors.forename: M
authors.initials: M
authors.lastname: Yokobori
authors.forename: K
authors.initials: K
authors.lastname: Kazui
authors.forename: T
authors.initials: T
authors.lastname: Hase
authors.forename: T
authors.initials: T
authors.lastname: Uematsu
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006111:Graves Disease / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D007453:Iodide Peroxidase / Q000276:immunology; D010146:Pain; D011877:Radionuclide Imaging; D011989:Receptors, Thyrotropin / Q000097:blood; D012008:Recurrence; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D013965:Thyroidectomy
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; C094372:thyrotropin-binding inhibitory immunoglobulin; D013954:Thyroglobulin; D007453:Iodide Peroxidase