[Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma].
OBJECTIVE
To explore the influence of blood transfusion on cellular immunofunction in patient with laryngeal carcinoma.


METHODS
EPICS-XL flow cytometry was used to measure T cell subgroup, NK cell and CD28 in 36 patients with laryngeal carcinoma pre-operation and 2 weeks post-operation. Patients were divided into allotransfusion group and non-transfusion group. Comparison was conducted between the 2 groups.


RESULTS
1. Comparison with normal population, decreasing of CD3, CD4, NK cell and CD28 in the 36 patients pre-operation was statistically significant (P < 0.01). 2. Decreasing of CD3, CD4, NK cell and CD28 was statistically significant post-operation (P < 0.05). 3. In the non-transfusion group change of CD3, CD4, CD8, NK cell and CD28 post-operation was statistically insignificant (P > 0.05).


CONCLUSIONS
While cellular immunofunction is generally low in patients with laryngeal carcinoma, allotransfusion will reduce further. It makes contribution to spreading and metastasis of carcinoma easier.
Wang
J
J
Department of Otolaryngology, First People's Hospital, Shanghai 200080.
Dai
C
C
Liu
S
S
Wang
S
S
Dong
H
H
Xie
K
K
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007430:Intraoperative Care; D007694:Killer Cells, Natural / Q000276:immunology; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D065227:Transfusion Reaction