Periodontal delivery of ipriflavone: new chitosan/PLGA film delivery system for a lipophilic drug.
The aim of the present work was to design a film dosage form for sustained delivery of ipriflavone into the periodontal pocket. For this purpose, monolayer composite systems made of ipriflavone loaded poly(D,L-lactide-co-glycolide) (PLGA) micromatrices in a chitosan film form, were obtained by emulsification/casting/evaporation technique. Multilayer films, made of three layers of polymers (chitosan/PLGA/chitosan), were also prepared and compared to monolayer films for their "in vitro" characteristics. Morphology and physico-chemical properties of the different systems were evaluated. The influence of pH, ionic strength and enzymatic activity on film degradation, was also investigated. Significant differences in swelling, degradation and drug release were highlighted, depending on film structure and composition. In vitro experiments demonstrated that the composite micromatricial films represent a suitable dosage form to prolong ipriflavone release for 20 days.
Perugini
P
P
Department of Pharmaceutical Chemistry, University of Pavia, V.le Taramelli 12, 27100, Pavia, Italy. paola.perugini@unipv.it
Genta
I
I
Conti
B
B
Modena
T
T
Pavanetto
F
F
D002686:Chitin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D048271:Chitosan; D016503:Drug Delivery Systems / Q000379:methods*; D007529:Isoflavones / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008055:Lipids / Q000008:administration & dosage / Q000493:pharmacokinetics; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000378:metabolism; D011100:Polyglycolic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012995:Solubility
D007529:Isoflavones; D008055:Lipids; D011108:Polymers; D002686:Chitin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C018986:ipriflavone; D048271:Chitosan