[Effect of small doses of ionizing radiation on selected antioxidant and immunologic parameters in patients with cervical cancer].
We analyzed the indices of antioxidant and immune systems in 69 patients with cervical carcinoma T3NxMo at different stages of radiotherapy. Radiation doses of 10-20 Gy were followed by certain normalization of antioxidant enzyme levels, increased concentrations of vitamins E and A in immunocompetent blood cells and improved the penetration and elastic properties of formed cells. The dosage stimulated the activity of helper-inducing and cytotoxic T-cells. Such effects should be taken into account when working out regimens of complex treatment of locally-advanced cervical carcinoma which include cytostatic drugs and radiation.
Frantsiiants
E M
EM
Research Institute of Oncology, Ministry of Health of the RF, Rostov-on-Don.
Rozenko
L Ia
LIa
Zlatnik
E Iu
EIu
Zakora
G I
GI
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011839:Radiation, Ionizing; D011879:Radiotherapy Dosage; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D013602:T-Lymphocytes, Cytotoxic / Q000528:radiation effects; D006377:T-Lymphocytes, Helper-Inducer / Q000528:radiation effects; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D014801:Vitamin A / Q000528:radiation effects; D014810:Vitamin E / Q000528:radiation effects
D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E