title: Dysfunction of wild-type huntingtin in Huntington disease.
abstract: Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD.
authors.affiliation: Department of Pharmacological Sciences and Center for Excellence in Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cattaneo
mesh_terms: D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins