[Prion diseases: current views].
This is a review of the problem. The above diseases represent a peculiar type of fatal neurodegenerative diseases of man and animals provoker of which is prion--a low molecular anucleinic protein resistant to inactivation. Human prior diseases include fatal familial sleeplessness, Kreutzfeldt-Jakob disease, kuru, Gerstmann-Streussler-Sheinker's syndrome, etc. Prion proteins possess a characteristic capacity to change a tertiary conformation resulting in the formation of a pathological form of protein having infectious properties. Pathogenesis, morphological and clinical manifestations as well as principles of diagnosis and treatment of these diseases are discussed.
Kogan
E A
EA
Zelenkov
P V
PV
Uspenskaia
O V
OV
Epifanov
Ia V
IaV
D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D017096:Prion Diseases / Q000145:classification / Q000209:etiology / Q000473:pathology*; D011328:Prions / Q000235:genetics / Q000472:pathogenicity*
D011328:Prions