Inhibitory effects of lapachol derivatives on epstein-barr virus activation.
Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods.
Sacau
Elisa Pérez
EP
Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez No. 2, E-38206, Tenerife, La Laguna, Spain.
Estévez-Braun
Ana
A
Ravelo
Angel G
AG
Ferro
Esteban A
EA
Tokuda
Harunkuni
H
Mukainaka
Teruo
T
Nishino
Hoyoku
H
D000215:Acylation; D000956:Antigens, Viral / Q000096:biosynthesis / Q000235:genetics; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D003500:Cyclization; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006900:Hydroxylation; D009285:Naphthoquinones / Q000494:pharmacology*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000956:Antigens, Viral; D000998:Antiviral Agents; D009285:Naphthoquinones; D011083:Polycyclic Compounds; C008252:lapachol