title: Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.
abstract: During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università 'La Sapienza', P. le A Moro 5, 00185, Rome, Italy. mariangela.biava@uniromal.it
authors.forename: Mariangela
authors.initials: M
authors.lastname: Biava
authors.forename: Giulio
authors.initials: G
authors.lastname: Cesare Porretta
authors.forename: Delia
authors.initials: D
authors.lastname: Deidda
authors.forename: Raffaello
authors.initials: R
authors.lastname: Pompei
authors.forename: Andrea
authors.initials: A
authors.lastname: Tafi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Manetti
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007202:Indicators and Reagents; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects*; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; D000995:Antitubercular Agents; D000998:Antiviral Agents; D007202:Indicators and Reagents; D009025:Morpholines; D010879:Piperazines; D011758:Pyrroles; C115651:BM 212; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin