title: Novel targets for antibiotic drug design.
abstract: The urgent need for new antibiotics has led to an explosion in the number and diversity of antibiotic drug targets under investigation. The majority of such targets are enzymes required for essential cellular functions. Often, such novel targets are completely unexploited for antibiotic therapy and therefore have the advantage of avoiding current resistance mechanisms. In general, the most advanced novel targets are drawn from processes where an existing antibacterial compound has validated that process for antibiotic therapy. This review describes a number of the more promising targets under development.
authors.affiliation: PanTherix Ltd, Todd Campus, West of Scotland Science Park, Glasgow, G20 0XA, UK.
authors.forename: Sohail T
authors.initials: ST
authors.lastname: Ali
authors.forename: Anne E
authors.initials: AE
authors.lastname: Gill
authors.forename: Ann
authors.initials: A
authors.lastname: Lewendon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents