Anti-inflammatory and anti-platelet aggregation activity of human placental extract.
OBJECTIVE
To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract (HPE, Placentrex).


METHODS
The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin (5-HT), and prostaglandin E1 (PGE1) induced edema in acute model and cotton pellet induced granuloma on sub-acute model. Anti-platelet aggregation was studied against protection of adinosine diphosphate (ADP)-induced aggregation of human platelet through in vitro study.


RESULTS
HPE showed positive results both in acute and sub-acute models of inflammation. Highly significant (P<0.01) results were obtained against 5-HT induced acute inflammation and cotton pellet induced sub-acute inflammation in comparison with standard (diclofenac sodium) and control (normal saline) drugs. The anti-inflammatory property of HPE in animal model was well supported with clinical study of platelet aggregation. There was highly significant (P<0.01) inhibition of platelet aggregation with HPE at different doses against ADP.


CONCLUSIONS
Our data suggest that human placental extract may be useful in suppressing inflammation and platelet aggregation.
Sur
Tapas Kumar
TK
Department of Pharmacology, Dr BC Roy Postgraduate Institute of Basic Medical Sciences 244B, Acharya J C Bose Road, Calcutta 700020, India.
Biswas
Tuhin Kanti
TK
Ali
Liaquat
L
Mukherjee
Biswapati
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D010924:Placental Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008419:Materia Medica; D010924:Placental Extracts; D010975:Platelet Aggregation Inhibitors