Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis.
Calprotectin has been proposed as a useful marker of inflammatory bowel disease in children. We did a pilot study to establish whether it can be used to aid diagnosis of necrotising enterocolitis in preterm infants. Patients with clinical features of necrotising enterocolitis had raised faecal calprotectin concentrations at the time of diagnosis compared with matched controls (288.4 mg/L [SD 49.1] and 98.0 mg/L [60.6], respectively; p=0.0006). Faecal calprotectin might be a useful marker of gastrointestinal mucosal inflammation in neonates.
Carroll
Daniel
D
Department of Paediatric Surgery, Bristol Royal Hospital for Sick Children, BS2 8BJ, Bristol, UK. danderosier@doctors.org.uk
Corfield
Anthony
A
Spicer
Richard
R
Cairns
Pamela
P
D016022:Case-Control Studies; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D008297:Male
D039841:Leukocyte L1 Antigen Complex