title: Surgical treatment of complete A-V canal defects in children before 3 months of age.
abstract: OBJECTIVE
  Surgical repair of complete A-V canal defects (CAVCD) is a well established procedure which is currently performed in infancy. The aim of this study is to evaluate surgical results of correction in early infancy in comparison to older age.
  
  
  METHODS
  From January 1985 to March 2001, 119 consecutive patients (age range 27 days to 83 months, mean 6.7 months) underwent repair of CAVCD in our Institution. Forms with unbalanced ventricles in association with Fallot's tetralogy or heterotaxia were excluded from this series. Fifty-eight patients (49%) underwent correction before 3 months of age (Group A), and 61 patients (51%) after 3 months (Group B). Surgical repair was accomplished with a double patch technique in 100 patients (84%). Associated surgical lesions were treated simultaneously in 48 patients (40%).
  
  
  RESULTS
  There were 11 operative deaths (<30 days) (two in Group A (3.4%) and nine in Group B (15%)) (P = 0.05). The remaining patients were discharged home in good haemodynamic condition. Reoperation for postoperative left A-V incompetence occurred in five patients in Group A and in eight patients in Group B. There were eight late deaths (three in Group A and five in Group B), of which four were non-cardiac related. At a mean follow-up time of 80 months (range 2-184 months) 100 patients are asymptomatic and well, and free from oral medication. Echocardiographic examination showed absent or mild residual left A-V valve incompetence in 91 patients (49 in Group A and 42 in Group B) and moderate left A-V valve incompetence in nine patients (four in Group A and five in Group B). Kaplan-Meier survival estimates at 10 years were 90% for Group A and 75% for Group B. Kaplan-Meier freedom from reoperation at 10 years was 89% for Group A and 84% for Group B.
  
  
  CONCLUSIONS
  Our data demonstrate that repair of CAVCD under 3 months of age is the ideal approach to this malformation with a lower mortality rate at operation compared to older patients. Logistic analysis showed that an operative age >3 months is, compared to an age < or =3 months, an incremental risk factor for hospital mortality with an odds ratio of 4.8 (95% confidence limit 1-23.5) (P = 0.05). In the long term, freedom from reoperation for left A-V valve incompetence is higher when compared to children repaired at an older age.
authors.affiliation: Department of Cardiovascular Surgery, University of Padova Medical School, Via Giustiniani, 2, 35128 Padova, Italy. giovanni.stellin@unipd.it
authors.forename: G
authors.initials: G
authors.lastname: Stellin
authors.forename: V L
authors.initials: VL
authors.lastname: Vida
authors.forename: O
authors.initials: O
authors.lastname: Milanesi
authors.forename: G
authors.initials: G
authors.lastname: Rizzoli
authors.forename: M
authors.initials: M
authors.lastname: Rubino
authors.forename: M A
authors.initials: MA
authors.lastname: Padalino
authors.forename: R
authors.initials: R
authors.lastname: Bonato
authors.forename: D
authors.initials: D
authors.lastname: Casarotto
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006343:Heart Septal Defects / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D012086:Reoperation; D012306:Risk; D016896:Treatment Outcome