Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells.
Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.
Nosach
Lidiya
L
Institute of Microbiology and Virology NAS of Ukraine, Kyiv, Ukraine. Dyachenko@serv.imv.kiev.ua
Dyachenko
Nataliya
N
Zhovnovataya
Valentina
V
Lozinskiy
Miron
M
Lozitsky
Victor
V
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000260:Adenoviruses, Human / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D014764:Viral Proteins / Q000378:metabolism*; D014771:Virion / Q000187:drug effects / Q000378:metabolism; D019065:Virus Assembly / Q000187:drug effects
D000998:Antiviral Agents; D014764:Viral Proteins; D010129:4-Aminobenzoic Acid; D015119:Aminocaproic Acid