Genotoxicity of lomefloxacin--an antibacterial drug in somatic and germ cells of Swiss albino mice in vivo.
The in vivo genotoxicity of lomefloxacin, a diflourinated antibacterial drug, was evaluated by employing mouse in vivo chromosomal aberration test in bone marrow cells and dominant lethal mutation assay in germ cells. Statistically significant reduction in mitotic index, increase in chromosomal aberrations (CAs)/cell and percent abnormal metaphase was observed only at the highest dose (160 mg/kg b.w.) of the drug. In the dominant lethal mutation assay, a statistically significant decrease in the number of implants/female, compared to vehicle control, was noticed only in the females mated with males treated with 32 mg/kg b.w. during the third week of mating, while statistically significant reduction in live implants/female was noticed at both the doses during the second and third weeks of mating. Nevertheless, no significant change in the number of dead implants/female was observed after lomefloxacin treatment. These results seems to indicate that lomefloxacin is a weak clastogen in the bone marrow cells and non-mutagenic in the germ cells of mouse in vivo.
Singh
Akhilesh C
AC
Genetic Toxicology Laboratory, Department of Botany and Biotechnology, Samastipur College, Samastipur 848134, India.
Kumar
Mithilesh
M
Jha
Anand M
AM
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D005298:Fertility / Q000187:drug effects; D024841:Fluoroquinolones; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D010063:Ovum / Q000187:drug effects; D015363:Quinolones / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009153:Mutagens; D015363:Quinolones; C053091:lomefloxacin