title: Interleukin-2 Increases CD4+ lymphocyte numbers but does not enhance responses to immunization: results of A5046s.
abstract: To ascertain whether CD4(+) lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4(+) lymphocyte counts, IL-2 did not enhance immunization responses.
authors.affiliation: Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA. valdez.hernan@clevelandactu.org
authors.forename: Hernan
authors.initials: H
authors.lastname: Valdez
authors.forename: Ronald
authors.initials: R
authors.lastname: Mitsuyasu
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
authors.forename: Anne D
authors.initials: AD
authors.lastname: Sevin
authors.forename: Ellen S
authors.initials: ES
authors.lastname: Chan
authors.forename: John
authors.initials: J
authors.lastname: Spritzler
authors.forename: Spyros A
authors.initials: SA
authors.lastname: Kalams
authors.forename: Richard B
authors.initials: RB
authors.lastname: Pollard
authors.forename: John
authors.initials: J
authors.lastname: Fahey
authors.forename: Lawrence
authors.initials: L
authors.lastname: Fox
authors.forename: Ann
authors.initials: A
authors.lastname: Namkung
authors.forename: Scharla
authors.initials: S
authors.lastname: Estep
authors.forename: Ronald
authors.initials: R
authors.lastname: Moss
authors.forename: David
authors.initials: D
authors.lastname: Sahner
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D022362:Hepatitis A Vaccines / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D019380:Anti-HIV Agents; D022362:Hepatitis A Vaccines; D017325:Hepatitis B Vaccines; D007376:Interleukin-2; D013745:Tetanus Toxoid