[Experience in treating cysticercosis of the brain with azinox].
A case of a patient resident from Tuva who had cerebral cysticercosis is presented. The diagnosis was established on the basis of the available clinical symptoms, brain RCT and NMRI findings and a positive serological reaction (enzyme immunoassay) with C. cellulosus antigen. The patient received 2 courses of treatment with the Russian drug azinox (praziquantel) in a daily dose of 50 mg/kg body weight thrice before meal. Prednisolone was additionally given in a daily dose of 30 mg. The course of treatment was 14 days. The first treatment days were marked by worse headache. Thereafter treatment induced no complications. Better condition, less headache, lower serological reaction titers, regressed cerebral structural changes were observed after the treatment. RCT and NMRI revealed transformation of cysts to high-density foci and calcificates.
Tumol'skaia
N I
NI
Glazunova
T I
TI
Dobzhanskiĭ
N V
NV
Sushurov
E B
EB
Stankov
D S
DS
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000097:blood; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D003552:Cysticercus / Q000302:isolation & purification; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020019:Neurocysticercosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011223:Praziquantel / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012698:Serologic Tests; D014057:Tomography, X-Ray Computed
D000871:Anthelmintics; D000893:Anti-Inflammatory Agents; D000909:Antibodies, Helminth; C078071:azinox; D011223:Praziquantel; D011239:Prednisolone