title: [A histopathologic and immunohistochemical study of 68 cases of hemangioblastoma].
abstract: The aim of this study was to evaluate the histologic characteristics of hemangioblastoma (HB) and investigate the histogenesis of its stromal cells. Sixty-eight cases of hemangioblastoma were studied by light microscopy and thirty-three cases were examined by immunohistochemical stainning. Forty-eight of the 68 patients were males and 20 were females. The average age was 37. Fifty-two cases (76.6%) had been present for two months to one year before the diagnosis was made. Sixty cases (88.2%) arose in the cerebellum. Fifty cases (73.5%) appeared as cystic nodules. Histologically, the 68 cases of HB were further categorized into three subtypes: typical (30 cases), cellular (21 cases) and reticular (17 cases). In 33 cases, the stromal cell were positive for NSE, but negative for F-VIII, UEA-1, GFAP and EMA. In summary, there are three essential histologic categories of hemangioblastoma, and its stromal cells may well have the characters of neuroendocrine differentiation.
authors.affiliation: Department of Pathology, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Pang
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology*; D002648:Child; D005260:Female; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D018325:Hemangioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D017154:Stromal Cells / Q000473:pathology
chemical_list: D010751:Phosphopyruvate Hydratase