Pharmacology and biology of corticotropin-releasing factor (CRF) receptors.
The biology of corticotropin-releasing factor (CRF) finds increasing interest in the scientific community because of the neuromodulatory actions of CRF on brain functions such as learning, anxiety, feeding, and locomotion. Additional actions on immunumodulation and apoptosis have recently been discovered. All actions of CRF are mediated by G protein-coupled receptors, which trigger different, sometimes opposite actions in different regions of the central nervous system. The CRF system exhibits considerable plasticity by the involvement of numerous different ligands, splice variants, and transductional couplings. The generation of multiple splice variants is facilitated by the intron exon structure of the CRF receptor genes.
Eckart
K
K
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, D-37075 Goettingen, Germany.
Jahn
O
O
Radulovic
J
J
Radulovic
M
M
Blank
T
T
Stiedl
O
O
Brauns
O
O
Tezval
H
H
Zeyda
T
T
Spiess
J
J
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001519:Behavior / Q000502:physiology; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D015398:Signal Transduction; D000099052:CRF Receptor, Type 1
C101518:CRF(2alpha) receptor; D002352:Carrier Proteins; D008024:Ligands; D018019:Receptors, Corticotropin-Releasing Hormone; C067133:corticotropin releasing factor-binding protein; D000099052:CRF Receptor, Type 1; D003346:Corticotropin-Releasing Hormone; D019204:GTP-Binding Proteins