[Measurement of central respiratory drive and inspiratory muscles strength in patients with uremia].
OBJECTIVE
To investigate the changes of central respiratory drive and inspiratory muscles function in patients with uremia.


METHODS
We performed the measurement of forced vital capacity (FVC), maximal voluntary ventilation (MBC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), maximal midexpiratory flow (MMEF), expiratory flow of 25 per cent of FVC (V25), lung carbon monoxide diffusing capacity (DLco), maximal inspiratory mouth pressure (MIP) and airway occlusion pressure (P0.1) in 25 patients with uremia and 20 normal subjects.


RESULTS
In patients with uremia, the FVC, MBC, FEV1, PEF, MMEF and V25 which reflect the lung ventilatory function and the DLco which reflects the lung diffusing function were significantly lower than those in normal subjects. The patients' MIP which reflects inspiratory muscles strength was significantly lower and their P0.1 which reflects the central respiratory drive was significantly higher, compared with the normal subjects'.


CONCLUSIONS
Our findings suggest that on the basis of the disorder of ventilation and diffusing function of the lungs, the inspiratory muscles function of the patients with uremia is significantly decreased and the central respiratory drive of the patients is increased.
Wang
Y
Y
Department of Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Xiao
M
M
Tang
X
X
Yang
L
L
Yuan
Y
Y
Luo
Y
Y
D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000503:physiopathology; D012125:Respiratory Center / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology*; D014511:Uremia / Q000503:physiopathology*