[Advances in the study of mechanisms of the tumor angiogenesis inhibitors].
Tumor angiogenesis inhibitor is the drugs which can destroy or inhibit neovascularization, and block the growth and metastasis of cancer. For clinical applications it may be useful to divide the antiangiogenic drugs into two categories: class 1(specific inhibitors) and class 2 (non-specific inhibitors). This review intends to provide the recent progress of the mechanisms of antiangiogenic drugs (1) Regulation of angiogenesis growth factors; (2) Inhibition of basement membrane degradation; (3) Mediating signal transduction pathway; (4) Effect of cell cycle; (5) Regulation of tumor-related gene.
Xiao
D
D
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031.
Ding
J
J
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*
D020533:Angiogenesis Inhibitors