The chelating treatment is not useful in human's intoxication with acute herbicidal organic arsenic.
The clinical manifestations of acute organic arsenic intoxication in humans have seldom been described and the associated treatment has been thought to be the same as that of acute inorganic arsenic intoxication. We have studied a collection of patients from 1996 to 2001 who called the Poison Control Center of Kaohsiung Medical University Hospital asking for information regarding acute organic arsenic intoxication. The 17 patients ranged in age from 23 to 64 years old, with 5 females and 12 males. The cause of arsenic ingestion was attempted suicide. Abdominal pain and vomiting were the main symptoms. There were no differences in results between patients treated with and those treated without chelating agents. We therefore believe that the results of acute organic intoxication are not same as acute inorganic intoxication and it is unnecessary to use chelating agents in such conditions.
Chou
C J
CJ
Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Tsai
M S
MS
Tsai
J L
JL
Lee
H H
HH
Lin
T J
TJ
D000208:Acute Disease; D000328:Adult; D001151:Arsenic / Q000493:pharmacokinetics; D020261:Arsenic Poisoning / Q000628:therapy*; D015913:Chelation Therapy; D005260:Female; D006540:Herbicides / Q000506:poisoning*; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D013406:Suicide, Attempted; D017211:Treatment Failure
D006540:Herbicides; D001151:Arsenic