HTLV-I carrier status disclosed at diagnosis of cytomegalovirus gastric ulcer.
A 50-year-old man experienced epigastric pain and gastrofiberscopy (GF) disclosed A2 to H1 stage multiple ulcerative lesions in the stomach. Inclusion bodies were found in the gastric mucosal cells of the biopsy specimen and the cells were positive for monoclonal antibody against cytomegalovirus. Serum HTLV-I antibody was positive and no atypical lymphocytes were seen in the peripheral blood. Gancyclovir and lansoprazole were given. A follow-up GF showed good ulcer healing with immunohistological improvement. The patient died from acute hepatic failure of undetermined cause eleven months after diagnosis. This is the first case report where a cytomegaloviral-induced gastric ulcer disclosed HTLV-I carrier state.
Watanabe
Jun'ichiro
J
Division of Cancer Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan. jwatanabe@jfcr.or.jp
Hatake
Kiyohiko
K
Ogata
Etsuroh
E
D000911:Antibodies, Monoclonal / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D002353:Carrier State; D003586:Cytomegalovirus Infections / Q000150:complications*; D017809:Fatal Outcome; D005753:Gastric Mucosa / Q000473:pathology / Q000648:ultrastructure; D015490:HTLV-I Infections / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D002479:Inclusion Bodies / Q000276:immunology; D017114:Liver Failure, Acute; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000821:virology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral