Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans.
Our purpose was to evaluate inherited short tandem repeat polymorphisms of the insulin-like growth factor II receptor gene (IGF2R) in oral cancer risk. The 197 individuals that consented to participate in a hospital-based, case-control study were interviewed with a structured questionnaire and provided blood and saliva. DNA was extracted for genotyping using a PCR-based method. Odds ratios were calculated using multivariate logistic regression. Subjects carrying the heterozygous 167-bp IGF2R genotype had a 2.7-fold higher risk of oral cancer compared with subjects with other genotypes (odds ratio = 2.7, 95% confidence interval: 1.16-6.48), controlling for major confounders. Our results suggest that genetic variation of IGF2R may influence significantly the risk of oral cancer.
Zavras
Athanasios I
AI
Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA.
Pitiphat
Waranuch
W
Wu
Tianxia
T
Cartsos
Vassiliki
V
Lam
Albert
A
Douglass
Chester W
CW
Diehl
Scott R
SR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D017527:Receptor, IGF Type 2 / Q000235:genetics*; D020080:Tandem Repeat Sequences
D017527:Receptor, IGF Type 2