title: Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia.
abstract: T-cell large granular lymphocyte (T-LGL) leukemia is an uncommon disease, with limited information on karyotypic aberrations. No consistent chromosomal changes have thus far been described. We report two cases of T-LGL leukemia who presented with severe anemia. The LGL were CD3+, CD4-, CD8+, CD56-, and CD161-, with variable expression of CD94, CD158a, and CD158b, and had clonal T-cell receptor gene rearrangement. A deletion of the long arm of chromosome 6 was the sole aberration in both cases. This is the first report of a recurrent chromosomal aberration in T-LGL leukemia.
authors.affiliation: Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Man
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: A
authors.initials: A
authors.lastname: Pang
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
mesh_terms: D015703:Antigens, CD / Q000235:genetics; D002051:Burkitt Lymphoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping
chemical_list: D015703:Antigens, CD