title: Constitutional rearrangements of 7q22 in hematologic malignancies. a new case report.
abstract: Abnormalities of chromosome 7 are a frequent finding in myelocytic malignancies and are associated with a poor prognosis. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and the second in region 7q32 approximately q35. The chromosomal breakpoint in band 7q22 appears to be heterogeneous and may involve tumor suppressor gene(s). Constitutional rearrangements of 7q22 have rarely been reported in myeloid malignancies. To our knowledge, this is the first report in the literature of a myeloproliferative disorder with a constitutional t(1;7)(q42;q22).
authors.affiliation: The Division of Hematology, Department of Medicine, Queen Elizabeth II Health Sciences Centre, Nova Scotia, Halifax, Canada. dforrest@is.dal.ca
authors.forename: Donna L
authors.initials: DL
authors.lastname: Forrest
authors.forename: Christine L Y
authors.initials: CL
authors.lastname: Lee
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D015321:Gene Rearrangement; D016147:Genes, Tumor Suppressor; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D009674:Nova Scotia; D044465:White People