title: Acute clinical hepatitis by immune restoration in a human immunodeficiency virus/hepatitis B virus co-infected patient receiving antiretroviral therapy.
abstract: We describe a human immunodeficiency virus (HIV)-infected patient with chronic active hepatitis B. The patient presented with acute clinical hepatitis during highly active antiretroviral therapy concomitant with immunovirological improvement of HIV infection. The hepatitis resolved within a few weeks despite the pursuit of antiretroviral drugs. Hepatitis B tests, which remained unchanged after two cycles of interferon alfa therapy and continuous administration of lamivudine, were improved with the clearance of hepatitis B virus (HBV) early antigen (HBeAg), the detection of antibody to HBV early antigen (HBeAb) and the undetectability of serum HBV DNA. Several months after this episode, HBV and HIV tests are still controlled.
authors.affiliation: Internal Medicine-A Pneumology Department, Gaston Doumergue Hospital, Nimes, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouanet
authors.forename: Hélène
authors.initials: H
authors.lastname: Peyrière
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Mauboussin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Terrail
authors.forename: Denis
authors.initials: D
authors.lastname: Vincent
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000208:Acute Disease; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006509:Hepatitis B / Q000150:complications*; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged