title: [Macular hole surgery: experience with autologous platelet concentrate and indocyanine green-assisted internal limiting membrane peeling].
abstract: BACKGROUND
  To report on our clinical experience with autologous platelet concentrate and indocyanine green(ICG)-assisted internal limiting membrane (ILM) peeling in macular hole surgery.
  
  
  METHODS
  Standard 3-port vitrectomy was performed in 107 eyes of 101 patients (m: f = 27 : 74; mean age 60 +/- 9, range 30 - 80 years) with idiopathic macular hole stages II - IV. After fluid/air exchange, autologous platelet concentrate was applied (1.9 +/- 0,1 x 10(8) thrombocytes). ILM peeling, which was preceded by ICG staining in 19 eyes, was performed in 34 patients.
  
  
  RESULTS
  After one procedure, anatomic success (hole closure) could be achieved in 85 % (n = 68), 75 % (n = 27) and 100 % (n = 3) of the eyes with stage II, III and IV holes, respectively. The mean visual acuity improved by 1 line. The overall initial closure rate of 82 % could be further enhanced to 96 % with a second procedure. In eyes pretreated with ICG, an initial rate of hole closure in 94 % and an improvement of visual acuity by 2 lines was observed.
  
  
  CONCLUSIONS
  Autologous platelet concentrate appears to be a safe and reliable adjunct to improve the anatomical outcome of conventional macular hole surgery. Functional results can be further enhanced by ICG-assisted ILM peeling
authors.affiliation: Augenklinik der Albert-Ludwigs-Universität Freiburg, Freiburg. kube@aug.ukl.uni-freiburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Kube
authors.forename: Martin
authors.initials: M
authors.lastname: Hermel
authors.forename: Claudia
authors.initials: C
authors.lastname: Dahlke
authors.forename: Gabriele
authors.initials: G
authors.lastname: Hutschenreuter
authors.forename: Norbert
authors.initials: N
authors.lastname: Schrage
authors.forename: Bernd
authors.initials: B
authors.lastname: Kirchhof
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets; D001804:Blood Transfusion, Autologous; D019773:Epiretinal Membrane / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008266:Macula Lutea / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D017713:Platelet Transfusion; D012167:Retinal Perforations / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods*
chemical_list: D009883:Ophthalmic Solutions; D007208:Indocyanine Green