title: Directionality of kinesin motors.
abstract: Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.
authors.affiliation: Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, L Pasteura 3, 020-093 Warszawa, Poland. aak@nencki.gov.pl
authors.forename: Andrzej A
authors.initials: AA
authors.lastname: Kasprzak
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Hajdo
mesh_terms: D000818:Animals; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000378:metabolism*; D009068:Movement; D011487:Protein Conformation
chemical_list: D020409:Molecular Motor Proteins; D016547:Kinesins