[Pharmacokinetic studies on artemether under conditions simulated in vivo].
Pharmacokinetics of artemether under conditions simulated in vivo was studied by high performance liquid chromatography. The pharmacokinetic curves of artemether and its metabolites dihydroartemisinin and furano acetate of artemether were determined and the results showed that the half-life of artemether under the conditions simulated the pH of plasma or small intestine was more than 150 min and that of stomach acid was 74.6 min. The results also showed that dihydroartemisinin and furano acetate of artemether were the main metabolites of artemether under the above conditions. Furthermore, the determination methods reported in literature were improved.
Chen
You-gen
YG
College of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210038, China.
Yu
Bo-yang
BY
D000077549:Artemether; D037621:Artemisinins / Q000032:analysis / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D016544:Patient Simulation; D012717:Sesquiterpenes / Q000032:analysis / Q000493:pharmacokinetics*
D037621:Artemisinins; D012717:Sesquiterpenes; C039060:artenimol; D000077549:Artemether