[Differential expression of cyclins D1, E and A in human breast diseases].
OBJECTIVE
To understand with greater clearness the effect of overexpression of cyclins gene and the potential implications of it for tumorgenesis in breast.


METHODS
We assayed the expression of cyclins D1, E and A in different types of human breast diseases by immunohistochemical staining.


RESULTS
Significant difference was seen among the malignant tumor, benign tumor and dysplasis(P < 0.001). The expressive intensity of above three kind of cyclins in malignant tumor was the highest, that in benign tumor was higher, and that in dysplasis was low.


CONCLUSIONS
These data suggest that the expressive intensity of cyclins gene may serve as an indicator for malignant intensity of tumors. The expressive ratio difference of cyclins E and A between infiltrating ductal carcinoma and infiltrating lobular carcinoma may imply that there are different mechanisms involving the occurrence of different histological types of breast tumor.
Ma
L
L
Laboratory Animal Center, WCUMS, Chengdu 610041, China.
Yin
H
H
Yang
W
W
Yang
G
G
Lü
Q
Q
Liu
X
X
D001943:Breast Neoplasms / Q000737:chemistry*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry*; D019925:Cyclin A / Q000032:analysis*; D019938:Cyclin D1 / Q000032:analysis*; D019927:Cyclin E / Q000032:analysis*; D005260:Female; D006801:Humans
D019925:Cyclin A; D019927:Cyclin E; D019938:Cyclin D1