title: Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.
abstract: Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Jacqueline D
authors.initials: JD
authors.lastname: Trudeau
authors.forename: Carolyn
authors.initials: C
authors.lastname: Kelly-Smith
authors.forename: C Bruce
authors.initials: CB
authors.lastname: Verchere
authors.forename: John F
authors.initials: JF
authors.lastname: Elliott
authors.forename: Jan P
authors.initials: JP
authors.lastname: Dutz
authors.forename: Diane T
authors.initials: DT
authors.lastname: Finegood
authors.forename: Pere
authors.initials: P
authors.lastname: Santamaria
authors.forename: Rusung
authors.initials: R
authors.lastname: Tan
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism; D007515:Islets of Langerhans / Q000276:immunology; D018655:Lymphocyte Count; D051379:Mice; D016688:Mice, Inbred NOD
chemical_list: D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I