Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.
During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
Biava
Mariangela
M
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università 'La Sapienza', P. le A Moro 5, 00185, Rome, Italy. mariangela.biava@uniromal.it
Cesare Porretta
Giulio
G
Deidda
Delia
D
Pompei
Raffaello
R
Tafi
Andrea
A
Manetti
Fabrizio
F
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007202:Indicators and Reagents; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects*; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; D000995:Antitubercular Agents; D000998:Antiviral Agents; D007202:Indicators and Reagents; D009025:Morpholines; D010879:Piperazines; D011758:Pyrroles; C115651:BM 212; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin