Characterization of soluble polymer supported organic compounds by LC/electrospray ionization MS toward a complete automation of the liquid-phase process in combinatorial chemistry.
In the case of a soluble polymer supported synthesis, the tuning of the support solubility depending on the solvent offers new opportunities for combinatorial chemistry for two reasons. First, organic syntheses in solution are generally easily translated on a soluble polymer supported substrate. Second, complete automation of the three successive steps of combinatorial chemistry (synthesis, analytical control, biological test) is approached without releasing the synthesized compound from the support. We report in this paper the preliminary results toward automation of both soluble polymer supported syntheses and their subsequent monitoring by ESI mass spectrometry.
Enjalbal
C
C
Laboratoire des Amino acides, Peptides et Protéines, UMR 5810, CNRS-Universités Montpellier I & II, Place E. Bataillon, 34095 Montpellier Cedex 05, France.
Lamaty
F
F
Sanchez
P
P
Suberchicot
E
E
Ribière
P
P
Varray
S
S
Lazaro
R
R
Yadav-Bhatnagar
N
N
Martinez
J
J
Aubagna
J L
JL
D001331:Automation; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D009930:Organic Chemicals / Q000138:chemical synthesis*; D011092:Polyethylene Glycols / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D009930:Organic Chemicals; D011092:Polyethylene Glycols