[Assessment of the status of biological health of the population of tundra Nentsy inhabiting northwestern Siberia from data on analysis of autoantibodies and lipoproteins from blood donors].
As a result of large-scale nuclear explosion on Novaya Zemlya test site (1955-62) the Tundra Nentsy population of Yamal-Nentsy autonomous region (YNAR) fell under constant influence of incorporated radioactive isotopes (137Cs and 90Sr). Therefore, it is very important to analyze a possible spectrum of diseases of Tundra Nentsy population. We have developed recently a new method for determination of concentrations of all main fraction and subfraction of lipoproteins (LP, 30 parameters) in human sera using small-angle X-ray scattering, and a general mathematical model to describe LP composition in human blood. The analysis of the 30 parameters characterizing fine spectrum of LPs in 374 YNAR natives showed that only approximately 10% of the donors are normal, while the indices for approximately 90% of the test subjects fall into the range of different pathologies (3-8% incidence in normal population, according to epidemiological studies). Moreover, we found that approximately 41% of European and approximately 56% of Tundra Nentsy have high level of autoantibodies to DNA and cardiolopine like the same for autoimmune diseases patients.
Nevinskiĭ
G A
GA
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Akademy of Sciences, Novosibirsk, 630090 Russia. nevinsky@niboch.nsc.ru
Osipova
L P
LP
Korovkina
E S
ES
Tuzikov
F V
FV
Tuzikova
N A
NA
Garmashova
N V
NV
Buneva
V N
VN
D001323:Autoantibodies / Q000097:blood*; D006305:Health Status Indicators; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D012542:Scattering, Radiation; D012800:Siberia / Q000453:epidemiology
D001323:Autoantibodies; D008074:Lipoproteins