LC method for the determination of oxcarbazepine in pharmaceutical preparations.
A simple and accurate HPLC method for determination of oxcarbazepine (OXC) in a new tablet formulation is described. Chromatographic separation was achieved on a Diamonsil C18 column using a mobile phase consisting of acetonitrile, potassium phosphate monobasic buffer (pH 6.8) and water (36:8:56, v/v) at a flow rate of 1.0 ml/min. Absorbance was monitored at 255 nm where OXC has maximum absorption. The linear range of detection for OXC was from 9.96 to 99.6 microg/ml. The proposed method was validated for selectivity, precision, accuracy and limits of detection and quantitation, etc.
Qi
M L
ML
Department of Chemistry, School of Chemical Engineering and Materials Science, Beijing Institute of Technology, 100081 Beijing, People's Republic of China. mlqi@bit.edu.cn
Wang
P
P
Wang
L J
LJ
Fu
R N
RN
D000927:Anticonvulsants / Q000032:analysis*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D000078330:Oxcarbazepine; D015203:Reproducibility of Results; D013607:Tablets
D000927:Anticonvulsants; D013607:Tablets; D002220:Carbamazepine; D000078330:Oxcarbazepine