title: Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity.
abstract: Immune mechanisms have important roles in the pathogenesis of atherosclerosis. The present study was conducted to evaluate the association of pulse wave velocity (PWV) with either hepatitis C or B. In 7514 subjects, we determined the PWV, as well as the plasma levels of hepatitis B virus antigen and antibody and of hepatitis C virus antibody. The results of multiple regression analysis showed that seropositivity for hepatitis C virus was a significant variable for PWV independent from atherosclerotic risk factors. Thus, hepatitis C virus seropositivity was associated with increased PWV.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. tomiyama@tokyo-med.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hirose
authors.forename: Sabroh
authors.initials: S
authors.lastname: Hori
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000276:immunology*; D001783:Blood Flow Velocity; D002353:Carrier State; D015331:Cohort Studies; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010991:Plethysmography; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D018709:Statistics, Nonparametric
chemical_list: D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies