Ubiquitin-dependent proteolysis in neurons.
Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases.
Klimaschewski
Lars
L
Institute of Anatomy and Histology, Deptartment of Neuroanatomy, University of Innsbruck, A-6010 Innsbruck, Austria.
D000818:Animals; D001927:Brain Diseases / Q000378:metabolism* / Q000473:pathology; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D046988:Proteasome Endopeptidase Complex; D025801:Ubiquitin / Q000378:metabolism*
D009097:Multienzyme Complexes; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex