title: [Purity analysis of cephalosporins with capillary zone electrophoresis].
abstract: A capillary zone electrophoresis method is proposed for the purity determination of nine cephalosporin drugs. A background electrolyte comprising of either 20 mmol/L pH 9.20 borate buffer or 20 mmol/L pH 6.86 phosphate buffer was used for most drugs studied except for cefaloridine which formed neutral molecules at these pH values. For it 50 mmol/L pH 2.05 phosphate buffer was used instead. Internal normalization method was employed for quantitation. The method is simple, rapid and versatile. Analysis was completed within 8 min. The merits and limitations of the method were also discussed.
authors.affiliation: Department of Chemistry, Peking University, Beijing 100871, China.
authors.forename: H
authors.initials: H
authors.lastname: Long
authors.forename: Q
authors.initials: Q
authors.lastname: Ding
authors.forename: T S
authors.initials: TS
authors.lastname: Wang
authors.forename: A J
authors.initials: AJ
authors.lastname: Huang
authors.forename: Y L
authors.initials: YL
authors.lastname: Sun
mesh_terms: D002437:Cefazolin / Q000032:analysis; D002439:Cefotaxime / Q000032:analysis; D002506:Cephalexin / Q000032:analysis; D002509:Cephaloridine / Q000032:analysis; D002511:Cephalosporins / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*
chemical_list: D002511:Cephalosporins; D002437:Cefazolin; D002509:Cephaloridine; D002439:Cefotaxime; D002506:Cephalexin