title: Primary brain tumours in adults.
abstract: The most frequent primary brain tumours in adults are gliomas and primary CNS lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification and treatment planning, a feature well illustrated by the chemosensitive oligodendrogliomas. Unfortunately, management of glioblastoma is still mainly palliative. Incidence of primary CNS lymphoma has increased strikingly in the past 20 years; substantial progress has been achieved in patients who are immunocompetent with the addition of methotrexate-based chemotherapy to radiotherapy, but the potential neurotoxic effects of this combination in elderly patients is worrisome.
authors.affiliation: Fédération de Neurologie Mazarin, G H Pitié-Salpêtrière, 75013, Paris, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Behin
authors.forename: Khe
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Carpentier
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D003131:Combined Modality Therapy; D005910:Glioma / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008967:Molecular Biology