[The effects of BDP on the inflammatory cells in nasal secretions of the patients with allergic rhinitis].
OBJECTIVE
To study the effects of beclomethasone dipropionate (BDP) on the inflammatory cells in nasal secretions of the patients with allergic rhinitis.


METHODS
The variation of intercellular RNA and RNA/DNA ratio of the eosinophils, neutrocyte and lymphocyte in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence.


RESULTS
The scanning images displayed that either in eosinophils or in neutrocyte, the fluorescence signal of intercellular RNA was significantly decreased after BDP treatment, and the intercellular RNA/DNA ratio was significantly reduced (eosinophils group P < 0.001, and neutrocyte group P < 0.01). The fluorescence singal of lymphocyte intercellular RNA and RNA/DNA ratio were not significantly changed (P > 0.05).


CONCLUSIONS
BDP can reduce the content of intercellular RNA of the eosinophils and neutrocyte. The anti-inflammation function of BDP is realized by regulating the intercellular RNA synthesize and/or RNA degradation, and by inhibiting the intercellular inflammatory medium production. BDP does not directly influence the intercellular RNA metabolize of the lymphocyte.
Shen
Z
Z
Department of Otolaryngology, First Affiliated Hospital of Shantou University Medical College, Shantou 515041.
Wang
H
H
Wang
H
H
Chen
Y
Y
Lin
J
J
Song
D
D
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001507:Beclomethasone / Q000494:pharmacology*; D004804:Eosinophils / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D001507:Beclomethasone