title: Coagulation factor VII activity, Arg/Gln353 polymorphism and features of insulin resistance in first-degree-relatives of South Asian patients with stroke.
abstract: The aim of the study was to determine associations of factor VII:C levels in 140 South Asian stroke subjects and 143 first-degree relatives versus age-sex matched 146 control subjects without a personal or a family history of stroke subjects living in UK. There were no significant differences in Factor VII:C levels or FVII Msp I gene polymorphism (Arg-Gln 353) R353Q genotype frequency between the groups. R353Q genotype determined Factor VII:C levels in all the three groups. Factor VII:C levels correlated with triglycerides (patients, r = 0.23; relatives r = 27; control subjects, r = 0.24) and plasminogen activator inhibitor activity (patients, r = 0.30; relatives r = 0.22; control subjects r = 0.20) in all the three groups, but with insulin only in patients (p = 0.19). Circulating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke.
authors.affiliation: Academic Unit of Molecular Vascular Medicine, University of Leeds, Leeds General Infirmary, Leeds, United Kingdom. k.kain@leeds.ac.uk
authors.forename: Kirti
authors.initials: K
authors.lastname: Kain
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Catto
authors.forename: John
authors.initials: J
authors.lastname: Young
authors.forename: John
authors.initials: J
authors.lastname: Bamford
authors.forename: John
authors.initials: J
authors.lastname: Bavington
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000941:Antigens / Q000097:blood*; D001208:Asia; D001483:Base Sequence; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000235:genetics* / Q000378:metabolism
chemical_list: D000941:Antigens; C042580:factor VII clotting antigen; D005167:Factor VII; D004247:DNA