title: Neonatal lupus erythematosus with recurrent pancytopenia: a case report.
abstract: Neonatal lupus erythematosus is an immune-mediated disease associated with the transplacental passage of maternal autoantibodies, primarily anti-Ro (SS-A) and anti-La (SS-B). The major clinical manifestations are isolated congenital heart block and cutaneous lupus lesions. Other symptoms include hematologic and hepatic abnormalities. We report a male neonate, born to a mother with Sjögren's syndrome, who experienced cutaneous lupus lesions and 2 episodes of pancytopenia. Both anti-Ro and anti-La antibodies were positive in infant and mother.
authors.affiliation: Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC.
authors.forename: Ling-Jen
authors.initials: LJ
authors.lastname: Wang
authors.forename: Yao-Hsu
authors.initials: YH
authors.lastname: Yang
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Lin
authors.forename: Bor-Luen
authors.initials: BL
authors.lastname: Chiang
authors.forename: Shu-Chi
authors.initials: SC
authors.lastname: Mu
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006327:Heart Block / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male; D010198:Pancytopenia / Q000150:complications*; D011247:Pregnancy; D012008:Recurrence; D012859:Sjogren's Syndrome / Q000235:genetics
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C035356:SS-A antibodies