title: A case of pulmonary adenocarcinoma associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor.
abstract: A 62-year-old male patient was admitted, because a chest X-ray examination revealed an abnormal shadow (4 cm in diameter) in the left upper lobe. A transbronchial lung biopsy showed the features of adenocarcinoma. Chest and abdominal computed tomography (CT) scan showed the features of lymphangitis carcinomatosa, and bilateral metastatic adrenal tumors. After effective chemotherapy, he complained of arthralgia and a bone scintigram showed abnormal uptakes in his bilateral shoulder, knee and wrist. He was diagnosed with pulmonary hypertrophic osteoarthropathy (PHOA). The serum level of vascular endothelial growth factor (VEGF) was elevated to 424 pg/ml, while serum growth hormone (GH) and GH-releasing hormone were normal. Immunohistochemical analysis showed positive features of VEGF in the pulmonary tumor cells. He died of cachexia on May 2nd, 2001, more than 2 years after the diagnosis of pulmonary adenocarcinoma at stage IV.
authors.affiliation: Department of Respiratory Disease, National Kanagawa Hospital, Ochiai 666-1, Kanagawa, 257-8585, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Abe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurita
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Ohkubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Usui
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hashizume
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ueyama
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Fujino
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D009077:Mucins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors