Effects of tGLP-1 on feeding behaviour and neurohypophysial function under chronic osmotic stimulation.
Effects of repeated daily intracerebroventricular injections of 1 microg of glucagon-like peptide-1 (7-36) amide (tGLP-1) on feeding and drinking behaviour, as well as neurohypophysial hormone secretion, was investigated in rats drinking tap water or 2% saline for 6 days. In euhydrated rats, tGLP-1 decreased moderately food and water consumption without a marked reduction of body weight. In salt-loaded rats, tGLP-1 considerably inhibited saline intake. On the other hand, food consumption and body weight changes were similar in vehicle- and tGLP-1-treated rats drinking 2% saline. Osmotic stimulation resulted in the augmented release of both neurohypophysial hormones. tGLP-1 did not alter plasma vasopressin and oxytocin concentrations either in euhydrated or osmotically stimulated rats. It is concluded that tGLP-1 may modify feeding and drinking behaviour under conditions of normal or disturbed water-electrolyte balance in the rat.
Bojanowska
Ewa
E
Department of Pathophysiology, Medical University of Lodz, 60 Narutowicza Street, PL-90-136, Lodz, Poland. ebojanow@mail.bg.am.lodz.pl
Stempniak
Bozena
B
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D006400:Hematocrit; D007276:Injections, Intraventricular; D008297:Male; D009994:Osmolar Concentration; D010121:Oxytocin / Q000097:blood / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000378:metabolism; D011498:Protein Precursors / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*
D010446:Peptide Fragments; D011498:Protein Precursors; D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin; D010121:Oxytocin; D052216:Glucagon-Like Peptide 1; D005934:Glucagon