Influence of low- and high-molecular-weight plasminogen activators on the onset of labor and on the hemostatic system.
Measurement of activities of urinary (u-PA) and tissue plasminogen activator (t-PA) and analysis of euglobulin lysis times (ELTs) and prekallikrein were performed simultaneously using the plasma of normal pregnant women and nonpregnant women. The activities of plasminogen activators were determined by the method of electrophoretic zymography. The activity of low-molecular-weight (LMW) u-PA was significantly decreased at the onset of labor (p = 0.05) compared with that during the latter half of pregnancy. The same tendency was observed in the analysis of prekallikrein. On the contrary, no significance was shown in activities of high-molecular-weight (HMW) u-PA or t-PA. It is suggested that the action of kallikrein on low-molecular-weight u-PA causes it to change into plasmin at the onset of labor.
Moriyama
Takanori
T
Department of Laboratory Technology, College of Medical Technology, Hokkaido University, N-12 W-5, Kita-ku, Sapporo 0600812, Japan. moriyama@cme.hokudai.ac.jp
Suzuki
Shigenori
S
Matsuno
Kazuhiko
K
Okada
Kiyotaka
K
Matsuo
Osamu
O
D016022:Case-Control Studies; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007745:Labor Onset / Q000097:blood*; D008970:Molecular Weight; D011247:Pregnancy; D011288:Prekallikrein / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000737:chemistry; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood* / Q000737:chemistry
D012712:Serum Globulins; D011288:Prekallikrein; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator