title: Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma.
abstract: A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiety and impatience. These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system.
authors.affiliation: Department of Neurology, J3R-166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands. pwwirtz@lumc.nl
authors.forename: Paul W
authors.initials: PW
authors.lastname: Wirtz
authors.forename: Peter A E
authors.initials: PA
authors.lastname: Sillevis Smitt
authors.forename: Jorrit I
authors.initials: JI
authors.lastname: Hoff
authors.forename: Bertie
authors.initials: B
authors.lastname: de Leeuw
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: Lammers
authors.forename: Sjoerd G
authors.initials: SG
authors.lastname: van Duinen
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Verschuuren
mesh_terms: D000368:Aged; D000912:Antibodies, Neoplasm / Q000096:biosynthesis / Q000097:blood*; D000951:Antigens, Neoplasm / Q000276:immunology*; D018567:Breast Neoplasms, Male / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D016601:RNA-Binding Proteins
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins