Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
Lin
Lie-Chwen
LC
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC. lclin@cma23.nricm.edu.tw
Yang
Ling-Ling
LL
Chou
Cheng-Jen
CJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D007651:Keto Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D029606:Plumbaginaceae / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D005960:Glucosides; D007651:Keto Acids; D009285:Naphthoquinones