Effect of Ginkgo biloba leaf extract on electroencephalography of rat with cerebral ischemia and reperfusion.
OBJECTIVE
To test the effect of Ginkgo biloba leaf extract on electroencephalography (EEG) during cerebral ischemia and reperfusion.


METHODS
Based on the quantitative analysis of EEG using the fast Fourier transform (FFT), the effect of Ginkgo biloba extract (GbE) on rat EEG was surveyed in the model of middle cerebral artery (MCA) occlusion and global cerebral ischemia.


RESULTS
In the global cerebral ischemia, GbE 8 and 16 mg/kg could accelerate the recovery of EEG after reperfusion, and GbE 4 mg/kg had the same effect but much weaker. In the MCA occlusion model, GbE 16 and 32 mg/kg greatly suppressed the drop of power spectrum of EEG.


CONCLUSIONS
GbE could mitigate the cerebral damage caused by ischemia.
Zhang
Yun-Yi
YY
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China. zhcheng@shmu.edu.cn
Li
Pei-Fen
PF
Li
Duan
D
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D005583:Fourier Analysis; D020441:Ginkgo biloba / Q000737:chemistry; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents