A-kinase-anchoring proteins and cytoskeletal signalling events.
Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cell properties such as shape, movement and division. Targeting of the cAMP-dependent kinase (protein kinase A) and other enzymes to this compartment is achieved through interaction with A-kinase-anchoring proteins (AKAPs). The present paper discusses recent progress on dissecting the biological role of WAVE1 (Wiskott-Alrich syndrome protein family verprolin homology protein 1), an AKAP that assembles a cytoskeletal transduction complex in response to signals that emanate from the low-molecular-mass GTPase, Rac.
Scott
J D
JD
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, 3181 Sam Jackson Park Road, Portland, OR 97201-3098, USA. scott@ohsu.edu
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D011485:Protein Binding; D015398:Signal Transduction; D051300:Wiskott-Aldrich Syndrome Protein Family; D020744:rac GTP-Binding Proteins / Q000378:metabolism
D002352:Carrier Proteins; D008840:Microfilament Proteins; D051300:Wiskott-Aldrich Syndrome Protein Family; D017868:Cyclic AMP-Dependent Protein Kinases; D020744:rac GTP-Binding Proteins