The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.
Successful drug delivery to the central nervous system (CNS) is highly dependent on DMPK as well as physicochemical properties and it is therefore important to characterise these properties and take them into account when designing chemical lead series that act at CNS targets. Since the drug discovery/development process is becoming increasingly focused on reducing the time required to enter molecules into the market, industrial DMPK scientists have emerged from their traditional supportive role in drug development to provide valuable support in the drug discovery process, using novel methods to meet the demands of combinatorial chemistry and bioscience groups.
Lundquist
Stefan
S
Department of DMPK Research, AstraZeneca R&D Södertälje, S-151 85 Södertälje, Sweden.
Renftel
Mila
M
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply; D002196:Capillaries / Q000166:cytology / Q000378:metabolism; D002199:Capillary Permeability; D002478:Cells, Cultured / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010539:Permeability