3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.
Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.
DeNinno
Michael P
MP
PGRD Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. michael_p_deninno@groton.pfizer.com
Masamune
Hiroko
H
Chenard
Lois K
LK
DiRico
Kenneth J
KJ
Eller
Cynthia
C
Etienne
John B
JB
Tickner
Jeanene E
JE
Kennedy
Scott P
SP
Knight
Delvin R
DR
Kong
Jimmy
J
Oleynek
Joseph J
JJ
Tracey
W Ross
WR
Hill
Roger J
RJ
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D043684:Receptor, Adenosine A3; D013329:Structure-Activity Relationship
D000577:Amides; C471165:CP 608039; D007555:Isoxazoles; D058906:Purinergic P1 Receptor Agonists; D043684:Receptor, Adenosine A3; D000241:Adenosine