Major Depressive Disorder (MDD) is associated with a primary defect within the serotonergic system.
Perlis
Michael
M
Sleep Research Laboratory, Department of Psychiatry, University of Rochester, NY 14642, USA. michael_perlis@urmc.rochester.edu
Smith
Michael
M
Orff
Henry
H
D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D012701:Serotonin / Q000378:metabolism*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000378:metabolism*; D012895:Sleep, REM / Q000502:physiology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D012701:Serotonin