Advanced renal cell carcinoma in which a combination of IFN-alpha and meloxicam was thought to be effective.
An 83-year-old man with left renal cell carcinoma (RCC; pT4N0M0) was treated with postoperative combined subcutaneous injection therapy of alpha interferon (IFN-alpha) and IFN gamma-1a (IFN-gamma-1a). Metastasis to the pleura occurred 3 months after surgery. The metastatic lesion grew while the treatment was changed to intramuscular injection of IFN-alpha-2b due to the presence of severe general malaise, which seemed to be caused by IFN-alpha and IFN-gamma therapy. As melosalgia associated with sciatica was also severe, treatment with meloxicam, which is known as a potent cyclooxigenase-2 inhibitor among commercially available non-steroidal anti-inflammatory drugs, was combined, resulting in significant improvement in activity of daily life, 43.2% decrease in the size of the pleural metastasis and complete regression of retroperitoneal residual tumor.
Yoshino
Shuji
S
Department of Urology, Japanese Red Cross Hospital Omori, Ota-ku, Tokyo, Japan. y-shuji@mvh.biglobe.ne.jp
Okabe
Tadashi
T
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D005221:Fatigue / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D000077239:Meloxicam; D009392:Nephrectomy; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000556:secondary; D011994:Recombinant Proteins; D012585:Sciatica / Q000188:drug therapy; D013843:Thiazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
D016861:Cyclooxygenase Inhibitors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007527:Isoenzymes; D011994:Recombinant Proteins; D013843:Thiazines; D013844:Thiazoles; D007371:Interferon-gamma; D000077239:Meloxicam