title: [Two cases of effective weekly paclitaxel administration and concurrent radiation for metastatic breast cancer].
abstract: We report two cases in which weekly paclitaxel (TXL) administration and concurrent radiation was effective for metastatic breast cancer. TXL (80 mg/m2) was infused over 1 hour after short premedication. Case 1: A 50-year-old woman was found to have atelectasis of the middle lobe after treatment for brain metastasis. She was diagnosed with hilar, mediastinal and supraclavicular lymph nodes metastases. She received weekly TXL administration and concurrent radiation to the mediastinum and supraclavicular fossa. The metastatic lymph nodes had disappeared one month after the treatment. Case 2: A 31-year-old woman was diagnosed with advanced breast cancer with lung, pleural, bone and orbital metastases. She received weekly TXL administration and concurrent radiation to the orbit. The lung and pleural metastases had disappeared and the orbital metastasis was decreased by 75% one month after the treatment, and the case was assessed as a partial response. Leukopenia and other major adverse effects were not observed in either of the two cases.
authors.affiliation: Dept. of Surgery, Itami City Hospital.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kokufu
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tanei
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Fukuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Tokiharu
authors.initials: T
authors.lastname: Yano
authors.forename: Katsumi
authors.initials: K
authors.lastname: Yamada
authors.forename: Koichi
authors.initials: K
authors.lastname: Tamaoka
authors.forename: Masako
authors.initials: M
authors.lastname: Hosono
mesh_terms: D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017239:Paclitaxel / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011838:Radiation-Sensitizing Agents; D017239:Paclitaxel