title: Structure and mechanism of the oestrogen receptor.
abstract: We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.
authors.affiliation: Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK.
authors.forename: E H
authors.initials: EH
authors.lastname: Kong
authors.forename: A C W
authors.initials: AC
authors.lastname: Pike
authors.forename: R E
authors.initials: RE
authors.lastname: Hubbard
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000502:physiology*; D020218:Response Elements; D015533:Transcriptional Activation
chemical_list: D020033:Protein Isoforms; D011960:Receptors, Estrogen