title: Adiponectin and protection against type 2 diabetes mellitus.
abstract: Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5.34 microg/mL [SD 3.49] vs 6.87 microg/mL [4.58], p<0.0001). High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A(1c) (odds ratio 4th vs 1st quartile 0.3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals.
authors.affiliation: Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany. spranger@mail.dife.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Spranger
authors.forename: Anja
authors.initials: A
authors.lastname: Kroke
authors.forename: Matthias
authors.initials: M
authors.lastname: Möhlig
authors.forename: Manuela M
authors.initials: MM
authors.lastname: Bergmann
authors.forename: Michael
authors.initials: M
authors.lastname: Ristow
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Andreas F H
authors.initials: AF
authors.lastname: Pfeiffer
mesh_terms: D052242:Adiponectin; D000328:Adult; D000368:Aged; D001824:Body Constitution; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology; D015444:Exercise; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics / Q000302:isolation & purification*; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins