Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice.
The murine gammaherpesvirus-68 kills I-A(b-/-) mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-A(b-/-) mice and I-A(b+/+) controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.
Belz
Gabrielle T
GT
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Liu
Haiyan
H
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Andreansky
Samita
S
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Doherty
Peter C
PC
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Stevenson
Philip G
PG
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018142:Gammaherpesvirinae / Q000472:pathogenicity*; D006183:H-2 Antigens / Q000378:metabolism; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology; D064532:Histocompatibility Antigen H-2D; D051379:Mice; D010446:Peptide Fragments / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006183:H-2 Antigens; C024755:H-2K(K) antigen; D064532:Histocompatibility Antigen H-2D; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta