title: [Effects of para-aminobenzoic acid (PABA) on growth of Streptococcus mutans].
abstract: OBJECTIVE
  The aim of this study is to examine effects of para-aminobenzoic acid (PABA) on the growth of Streptococcus mutans (S. mutans).
  
  
  METHODS
  Different concentrations of PABA (10(-10)-10(-3) g/L) were separately transferred to modified Carlsson medium. S. mutans (ATCC 25175) grew in modified Carlsson medium with different concentrations of PABA. All cultures were incubated at 37 degrees C anaerobically in an atmosphere of 80% of nitrogen (v/v), 10% of hydrogen (v/v) and 10% of carbon dioxide (v/v) for 48 hours. The absorbance values of S. mutans were measured by using a spectrometer (UV-1601). The colony forming units (CFU) were obtained by growing S. mutans in media with different concentrations of PABA (10(-10)-10(-3) g/L).
  
  
  RESULTS
  Different concentrations of PABA had different stimulating effects on the growth of S. mutans (P < 0.05). But this kind of stimulating effects declined when the concentration of PABA was 10(-3) g/L.
  
  
  CONCLUSIONS
  This experiment indicates PABA has stimulating effects on the growth of S. mutans, and PABA can promote growth of S. mutans.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: B
authors.initials: B
authors.lastname: Guo
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Xiao
authors.forename: T
authors.initials: T
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
authors.forename: L
authors.initials: L
authors.lastname: Li
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D062366:para-Aminobenzoates
chemical_list: D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid