Small G proteins as novel therapeutic targets in cardiovascular medicine.
Small G proteins are implicated in regulation of endothelial function, smooth muscle cell contraction, proliferation, and migration, as well as cardiomyocyte hypertrophy. Targeting small G proteins and their downstream signaling could constitute promising therapeutic approaches in cardiovascular disorders such as atherosclerosis, restenosis, hypertension, vasospasm, and cardiac hypertrophy.
Barandier
Christine
C
Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Ming
Xiu-Fen
XF
Yang
Zhihong
Z
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans
D019204:GTP-Binding Proteins