Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks.
The present study was done to clarify whether intracerebroventricular (ICV) injection of cocaine- and amphetamine-regulated transcript (CART) affects feeding in chicks. ICV injection of CART significantly inhibited fasting-induced feeding of broiler chicks. In layer chicks, on the other hand, CART inhibited food intake in birds with ad libitum access to feed but only weakly affected intake of fasted birds. In addition, the ICV injection of CART attenuated neuropeptide Y (NPY)-induced feeding in both broiler and layer chicks. These results indicate that CART is one of the important regulators of feeding in chicks, but the suppressive effect on feeding is somewhat different between strains. Furthermore, the present study also demonstrates that CART interacts with NPY in the central nervous system to regulate feeding in chicks.
Tachibana
Tetsuya
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, 812-8581, Fukuoka, Japan. tetsu@brs.kyushu-u.ac.jp
Takagi
Tomo
T
Tomonaga
Shozo
S
Ohgushi
Atsushi
A
Ando
Ryuichi
R
Denbow
D Michael
DM
Furuse
Mitsuhiro
M
D000367:Age Factors; D000818:Animals; D002645:Chickens / Q000145:classification / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D005215:Fasting / Q000502:physiology; D007276:Injections, Intraventricular / Q000379:methods; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000494:pharmacology; D013997:Time Factors; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein