title: [Study of reparative DNA synthesis in lymphocytes of persons occupationally exposed to radiation].
abstract: The UDS efficiency in lymphocytes of professionals chronically exposed to gamma/neutron radiation, as well as for a control cohort was estimated. A credible reduction of UV-induced UDS (KUV) index as compared to the control was demonstrated. This shows an invalid repair state of blood cells in professionals. As for the control cohort, the decreasing tendency of UDS index with age was found. The correlative analysis of UDS index dependence upon an absorbed dose (based on physical dosimetry data) revealed the trend towards repair index reduction along with a higher total absorbed doze, that is followed by UDS index coming onto a plateau. It was also demonstrated that after a sharp and/or accidental irradiation UDS index reduces as compared to permanent portioned irradiation. It was not observed the influence of smoking upon UDS efficiency in blood lymphocytes neither for control, nor for experimental group. The analysis of vitamin therapy of the both cohorts showed that such therapy raises UDS index of the control (i.e., non-professional) group. Besides, it was found out an additional positive effect of vitamin therapy, i.e. doze leveling in long-term perspective after irradiation. The most expressed KUV/doze correlation was characteristic for professionals, who do not take vitamins and do not smoke. This proves that in blood cells of professionals it is preserved a dependence of repair system invalidity upon the absorbed doze without similar external factors.
authors.affiliation: All-Russian Research Institute of Experimental Physics, Sarov, 607190 Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Nikanorova
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Ivanov
authors.forename: T I
authors.initials: TI
authors.lastname: Khaĭmovich
authors.forename: S N
authors.initials: SN
authors.lastname: Ptitsina
authors.forename: V A
authors.initials: VA
authors.lastname: Shevchenko
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004260:DNA Repair; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009502:Neutrons; D016273:Occupational Exposure; D011210:Power Plants; D012907:Smoking / Q000235:genetics; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014815:Vitamins