[The proliferating cells in the rat endolymphatic sac].
OBJECTIVE
To study the cellular proliferating activity of the endolymphatic sac.


METHODS
10 healthy adult S-D rats were used for the experiment. After administration of 5-bromo-2'-deoxyuridine (BrdUrd) intraperitoneally, the rats were sacrificed and the temporal bones were removed, then the decalcified samples examined immunohistochemically by using monoclonal antibodies against BrdUrd.


RESULTS
Scattered BrdUrd+ cells were detected within the endolymrhatic sac (ES) whereas labelled cells were not fonnd in the cochlea.


CONCLUSIONS
Possessing a low rat of mitotic activity, the ES may be an important the sole site for the cell-renewing in the inner ear.
Huang
X W
XW
Department of Otolaryngology, Union Hospital, Tongji Medical University, Wuhan 430022.
Xiao
H J
HJ
Wang
J B
JB
Huang
X
X
D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D004712:Endolymphatic Sac / Q000166:cytology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016196:S Phase / Q000502:physiology
D001973:Bromodeoxyuridine