Novel dic(16;18)(q11;p11) in two cases of Philadelphia chromosome positive acute B-cell lymphoblastic leukemia.
We report two adult patients with Philadelphia chromosome positive (Ph+) B-cell acute lymphoblastic leukemia (ALL) who presented an additional dic(16;18)(q11;p11) that, to the best of our knowledge, has never been previously reported. Fluorescence in situ hybridization analysis confirmed the translocation and showed it to be dicentric. Both patients were treated for the ALL, but showed refractory disease and died despite aggressive treatment. Similarly to what has been reported with other additional chromosome abnormalities, our cases suggest that the presence of this novel translocation confers an adverse effect to the already poor prognosis of Ph+ ALL.
Domingo-Domènech
Eva
E
Department of Hematology and Cytology, Institut Català d'Oncologia, Ciudad Sanitaria y Universitaria de Bellvitge, Barcelona, Spain. 31577edd@comb.es
Boqué
Concha
C
Aventin
Ana
A
Calasanz
Maria Jose
MJ
Valiente
Alberto
A
Perez-Equiza
Katy
K
Domingo-Clarós
Alicia
A
Grañena
Albert
A
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male