Analysis of Wuchereria bancrofti infections in a village community in northern Nigeria: increased prevalence in individuals infected with Onchocerca volvulus.
Infections with Wuchereria bancrofti causing lymphatic filariasis still represent one of the major health problems in the tropics, with 120 million people infected and over 750 million exposed to this filarial parasite. We have studied lymphatic filariasis infections as part of a multi-parasite survey in a village community in the savannah of northern Nigeria. We analysed serum samples from 341 individuals aged 5-70 years, detecting a W. bancrofti circulating antigen using the commercially available ICT Filariasis card test. The prevalence of infections was 10% and clearly age-dependent, increasing from below 2% in children to over 20% in subjects older than 40 years. Measuring IgG4 antibodies against the recombinant W. bancrofti antigen SXP1 showed that 36% of all tested individuals had been at least exposed to the parasite. Antibody levels also increased very significantly with age. A further analysis measuring Onchocerca volvulus-specific IgG4 antibodies showed a very significant association between infections with O. volvulus and those with W. bancrofti. Our data show that infections with W. bancrofti in Nigeria are still a frequently occurring health problem, since they are more prevalent than previously reported, and that individuals with an O. volvulus infection are more often infected with W. bancrofti than expected statistically.
Engelbrecht
Fred
F
Department of Parasitology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany. engelbrecht.fred@reenet.de
Oettl
Tobias
T
Herter
Ursula
U
Link
Claudia
C
Philipp
Diana
D
Edeghere
Henry
H
Kaliraj
P
P
Enwezor
Felicia
F
D000368:Aged; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005368:Filariasis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D017181:Onchocerca volvulus / Q000302:isolation & purification; D009855:Onchocerciasis / Q000150:complications* / Q000175:diagnosis / Q000469:parasitology; D015995:Prevalence; D013045:Species Specificity; D014958:Wuchereria bancrofti / Q000472:pathogenicity
D000909:Antibodies, Helminth; D007074:Immunoglobulin G