[Neurobiological problems of brain ischemia and post stroke epilepsy].
A review. Current literature data concerning pathophysiological mechanisms of cerebral ischemia and poststroke epilepsy are presented. Results of investigations of structural-functional changes in activity of inhibitory inter neurons, mechanisms of brain plasticity, and main components of neuroprotection in ischemia are also discussed. The presented data confirm the current concept of apoptosis and necrosis as a consequence of injuring action of ischemia, the role of excitotoxicity in pathogenesis of ischemia and poststroke epilepsy, and different kinds of plasticity in recovery of brain functions.
Sorokina
N D
ND
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Selitskiĭ
G V
GV
Kositsyn
N S
NS
Svinov
M M
MM
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology*; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D009473:Neuronal Plasticity; D009474:Neurons / Q000473:pathology / Q000502:physiology; D020521:Stroke / Q000150:complications / Q000503:physiopathology*