[Susceptibility of wild and knockout p53 FVB/N line mice to benz(a)pyrene-induced subcutaneous sarcoma].
Susceptibility to benz(a)pyrene (BP) has been compared between wild and knockout p53 homo- and heterozygous FVB/N, C57BL/6 and NMRI line mice. Each group included 34-80 animals. Each animal was injected 2 mg BP, s.c., in sunflower oil solution. The animals were followed up for 24 weeks. Fibrosarcomas arose at the site of injection in: wild FVB/N line mice--93%; FVB/N heterozygous--100%; p53 homozygous knockout--95%; C57B1/6--84%, and NMRI mice--83%. Mean latent period was 68, 66, 69, 112 and 109 days, respectively. Hence, FVB/N line mice developed tumors much earlier than C57B1/6 or NMRI did, suggesting their higher susceptibility to carcinogenic BP injection. No significant difference in susceptibility to carcinogen versus p53 expression was reported.
Anikin
I V
IV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Kozlov
A P
AP
Popov
A V
AV
Zabezhinskiĭ
M A
MA
Tyndyk
M L
ML
Anisimov
V N
VN
D000818:Animals; D001564:Benzo(a)pyrene; D002273:Carcinogens; D005354:Fibrosarcoma / Q000139:chemically induced / Q000235:genetics*; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency* / Q000235:genetics
D002273:Carcinogens; D016159:Tumor Suppressor Protein p53; D001564:Benzo(a)pyrene