title: Expression of surface protein receptors in lung cancer.
abstract: Cell adhesion is a basic count in inter- and intracellular communication and plays an important role in tumor progression. In this study, the expression of E-selectin, ICAM-1 and VCAM-1 were evaluated by means of immunohistochemistry in a group of 153 lung cancer specimens. E-selectin immunoreactivity was localized mostly on endothelial cell venules and capillaries with an average staining intensity of 75% of cells in the NSCLC, while in SCLC the intensity of the staining was 69%. The staining pattern for ICAM-1 reached an average intensity of 57%, in both NSCLC and SCLC. Finally, VCAM-1 immunoreactivity was detected only in NSCLC with an average intensity of 12% on endothelial cell venules and capillaries. This study provides a contribution towards the understanding of the basic mechanisms of cell adhesion in lung cancer progression.
authors.affiliation: III Division A. O. D. Cotugno Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Esposito
authors.forename: Angela M
authors.initials: AM
authors.lastname: Groeger
authors.forename: Luca
authors.initials: L
authors.lastname: De Luca
authors.forename: Mariapia
authors.initials: M
authors.lastname: Di Marino
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.forename: Paolo
authors.initials: P
authors.lastname: Marchei
authors.forename: Feliciano
authors.initials: F
authors.lastname: Baldi
authors.forename: Ernst
authors.initials: E
authors.lastname: Wolner
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D015153:Blotting, Western; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D019040:E-Selectin / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1