title: A pharmacoeconomic evaluation of 7-valent pneumococcal conjugate vaccine in Canada.
abstract: The objective of this study was to evaluate the projected health benefits, costs, and cost-effectiveness of pneumococcal conjugate vaccination for infants and children aged <5 years in Canada. A health state model incorporating incidence, vaccine efficacy, costs, and transitional probabilities for the health states (well, meningitis, bacteremia, otitis media, pneumonia, and death) was constructed for a 10-year time horizon. Implementation of a pneumococcal conjugate vaccine program in Canada for each annual birth cohort of 340,000 persons observed over 10 years would be expected to save approximately 12 lives and 100,000 cases of pneumococcal disease over 10 years, resulting in total savings of $67 million (Canadian dollars [Can$]). Vaccination of healthy infants would result in net savings for society if the vaccine costs less than Can$50 per dose. Moreover, for a vaccine purchase price of Can$67.50, infant vaccination would cost society Can$79,000 per life-year gained. Pneumococcal conjugate vaccination is a potentially cost-effective means of pneumococcal disease prevention.
authors.affiliation: Division of Infectious Diseases, Sainte-Justine Hospital, University of Montreal, Quebec, Canada.
authors.forename: Marc H
authors.initials: MH
authors.lastname: Lebel
authors.forename: James D
authors.initials: JD
authors.lastname: Kellner
authors.forename: E Lee
authors.initials: EL
authors.lastname: Ford-Jones
authors.forename: Kyle
authors.initials: K
authors.lastname: Hvidsten
authors.forename: Edward C Y
authors.initials: EC
authors.lastname: Wang
authors.forename: Vincent
authors.initials: V
authors.lastname: Ciuryla
authors.forename: Steve
authors.initials: S
authors.lastname: Arikian
authors.forename: Roman
authors.initials: R
authors.lastname: Casciano
mesh_terms: D002170:Canada; D003362:Cost-Benefit Analysis; D005260:Female; D017048:Health Care Costs; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000191:economics*; D018570:Risk Assessment; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000191:economics*
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate