[Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance].
OBJECTIVE
To investigate the effects of ketamine on cardiopulmonary bypass-induced IL-6 and IL-8 response.


METHODS
Twenty-four adult patients undergoing cardiac valve replacement were divided into control and ketamine group (n = 12). In the ketamine group, 1 mg.kg-1 ketamine was infused intravenously at the beginning of operation and CBP. Plasma levenof IL-6 and IL-8 were measured at different time after induction of anesthesia.


RESULTS
In both groups, the levels of IL-6 and IL-8 increased significantly compared with those at the time before CBP (P < 0.05), but compared with those in control groups, IL-6 and IL-8 levels decreased obviously in ketamine group(P < 0.05).


CONCLUSIONS
Ketamine is effective to reduce cardiopulmonary bypass-induces IL-6 and IL-8 response and protect reperfusion myocardium.
Cao
D Q
DQ
Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Chen
Y P
YP
Zou
D Q
DQ
D000328:Adult; D000778:Anesthetics, Dissociative; D002315:Cardiopulmonary Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D007649:Ketamine; D008297:Male; D008875:Middle Aged
D000778:Anesthetics, Dissociative; D015850:Interleukin-6; D016209:Interleukin-8; D007649:Ketamine