title: [Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma].
abstract: OBJECTIVE
  To explore the influence of blood transfusion on cellular immunofunction in patient with laryngeal carcinoma.
  
  
  METHODS
  EPICS-XL flow cytometry was used to measure T cell subgroup, NK cell and CD28 in 36 patients with laryngeal carcinoma pre-operation and 2 weeks post-operation. Patients were divided into allotransfusion group and non-transfusion group. Comparison was conducted between the 2 groups.
  
  
  RESULTS
  1. Comparison with normal population, decreasing of CD3, CD4, NK cell and CD28 in the 36 patients pre-operation was statistically significant (P < 0.01). 2. Decreasing of CD3, CD4, NK cell and CD28 was statistically significant post-operation (P < 0.05). 3. In the non-transfusion group change of CD3, CD4, CD8, NK cell and CD28 post-operation was statistically insignificant (P > 0.05).
  
  
  CONCLUSIONS
  While cellular immunofunction is generally low in patients with laryngeal carcinoma, allotransfusion will reduce further. It makes contribution to spreading and metastasis of carcinoma easier.
authors.affiliation: Department of Otolaryngology, First People's Hospital, Shanghai 200080.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Dai
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Dong
authors.forename: K
authors.initials: K
authors.lastname: Xie
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007430:Intraoperative Care; D007694:Killer Cells, Natural / Q000276:immunology; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D065227:Transfusion Reaction