title: New approaches for treatment of diabetic nephropathy: the endothelium as a target for drug discovery.
abstract: Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). There are currently no therapeutic Hyperlipidaemiants which directly intervene in the pathogenesis of diabetic nephropathy. The mechanisms behind development of diabetic nephropathy are complex and not completely understood. The hyperglycaemia, hyperlipidaemia and hyperinsulinaemia found in diabetics might all act on the kidney endothelium to induce expression of genes important in kidney dysfunction. We propose that targeting kidney endothelial gene expression may provide a new approach for control of kidney dysfunction.
authors.affiliation: Reddy US Therapeutics Inc., 3065 Northwoods Circle, Norcross, GA 30071 USA. usaxena@reddyus.com
authors.forename: Uday
authors.initials: U
authors.lastname: Saxena
authors.forename: Richard T
authors.initials: RT
authors.lastname: Timmer
authors.forename: Sivaram
authors.initials: S
authors.lastname: Pillarisetti