title: Decreased levels of fibrinogen in very high parity women.
abstract: OBJECTIVE
  To evaluate coagulation parameters in healthy pregnant grand grand multiparous women.
  
  
  METHODS
  Prothrombin time (PT), activated partial thromboplastin time (PTT), fibrinogen, D-dimer, albumin and blood lipids were prospectively determined in 50 pregnant grand grand multiparas (> or =9 deliveries) and 50 age-matched pregnant women with low parity (< or =3 deliveries).
  
  
  RESULTS
  The average concentrations of fibrinogen in the grand grand multiparas were 4.0+/-0.6 as compared to 4.7+/-0.7 g/l in the control group (P<0.001). In both groups D-dimer levels were >1000 ng/ml and the concentrations of albumin, triglycerides, cholesterol, high-density lipoprotein (HDL) were not significantly different.
  
  
  CONCLUSIONS
  In healthy pregnant grand grand multiparous women fibrinogen levels are lower than in age-matched women with low parity. These changes are not directly associated with lipids metabolism during pregnancy.
authors.affiliation: Division of Clinical Laboratories, Bikur Cholim Hospital, 5 Strauss Street, 91004, Jerusalem, Israel. almagors@hotmail.com
authors.forename: Miriam
authors.initials: M
authors.lastname: Almagor
authors.forename: Diana
authors.initials: D
authors.lastname: Gorten
authors.forename: Haim
authors.initials: H
authors.lastname: Yaffe
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D010298:Parity / Q000502:physiology*; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011446:Prospective Studies; D011517:Prothrombin Time; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; D012709:Serum Albumin; C036309:fibrin fragment D; D005340:Fibrinogen; D002784:Cholesterol