MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules.
CONCLUSIONS
Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.


BACKGROUND
Freely accessible from http://surya.bic.nus.edu.sg/mpid.
Govindarajan
Kunde Ramamoorthy
KR
Department of Biochemistry, National University of Singapore, Singapore 119260.
Kangueane
Pandjassarame
P
Tan
Tin Wee
TW
Ranganathan
Shoba
S
D001665:Binding Sites; D003628:Database Management Systems; D030562:Databases, Protein; D006649:Histocompatibility Antigens / Q000737:chemistry; D016247:Information Storage and Retrieval / Q000379:methods; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D010446:Peptide Fragments / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014584:User-Computer Interface
D006649:Histocompatibility Antigens; D046911:Macromolecular Substances; D010446:Peptide Fragments; D010455:Peptides