[Expression and significance of TGF-beta 1 in nasal polyps].
OBJECTIVE
To study the expression and significance of transforming growth factor-beta 1(TGF-beta 1) in nasal polyps.


METHODS
Expression of TGF-beta 1 in nasal polyps from 34 patients and middle turbinates from 30 patients with deviation of nasal septum were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope.


RESULTS
1. The TGF-beta 1 positivity in extracellular matrix and in cells in the stroma was significantly higher in nasal polyps than in middle turbinates (P < 0.01). 2. The distribution and shape of TGF-beta 1 expressing cells in nasal polyps was similar to that of eosinophil, their positivities were significantly correlative (P < 0.05). 3. The positivity of TGF-beta 1 did not correlate with clinical type of nasal polyps (P > 0.05), eosinophil infiltration correlated significantly with clinical type of nasal polyps(P < 0.05).


CONCLUSIONS
1. The TGF-beta 1 may contribute to some of the pathologic changes observed in nasal polyps, such as thickening of the epithelial basement membrane and stromal fibrosis. 2. Eosinophils in nasal polyps represent a major source of TGF-beta 1. 3. Eosinophils infiltration may play a prominent role in the development and recurrence of nasal polyps.
Guo
J
J
First Affiliated Hospital of Inner Mongolia Medical College, Huhehaote 010050.
Liu
M
M
Wang
X
X
Tao
H
H
Zhang
H
H
Han
D
D
Zhu
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1