Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness.
Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.
Henderson
R F
RF
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA. rhenders@lrri.org
Barr
E B
EB
Blackwell
W B
WB
Clark
C R
CR
Conn
C A
CA
Kalra
R
R
March
T H
TH
Sopori
M L
ML
Tesfaigzi
Y
Y
Ménache
M G
MG
Mash
D C
DC
Dokladny
K
K
Kozak
W
W
Kozak
A
A
Wachulec
M
M
Rudolph
K
K
Kluger
M J
MJ
Singh
S P
SP
Razani-Boroujerdi
S
S
Langley
R J
RJ
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002619:Chemical Warfare Agents / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology*; D004195:Disease Models, Animal; D007107:Immune System / Q000187:drug effects; D019570:Inhalation Exposure; D008569:Memory Disorders / Q000209:etiology*; D018923:Persian Gulf Syndrome; D051381:Rats; D011916:Rats, Inbred F344; D011950:Receptors, Cholinergic / Q000032:analysis* / Q000187:drug effects; D012524:Sarin / Q000009:adverse effects*
D002619:Chemical Warfare Agents; D011950:Receptors, Cholinergic; D012524:Sarin