[Nutrition and health--favorable effect of wine and wine flavonoids on cardiovascular diseases].
Epidemiological studies have shown a favourable effect of moderate alcohol consumption with regard to atherosclerotic disorders. In addition to alcohol, wine contains a large number of other components including polyphenols. These polyphenols mainly originate from the skins and seeds of grapes and, because of differences in vinification, their variety and concentration is higher in red wine than in white wine. In vitro and ex vivo studies have shown that some of these polyphenols are able to slow down LDL-cholesterol oxidation, stimulate NO production, influence prostaglandin synthesis and inhibit platelet aggregation. However, little is known about their resorption, bioavailability and effectiveness in vivo. Since data from intervention studies with wine polyphenols are also lacking, no statement can yet be made about any clinically relevant effect of these components, in either red or white wine, in terms of cardiovascular diseases.
van de Wiel
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A
Meander Medisch Centrum, afd. Interne Geneeskunde, Postbus 1502, 3800 BM Amersfoort. a.wiel@meandermc.nl
D000428:Alcohol Drinking; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010084:Oxidation-Reduction; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D011108:Polymers / Q000494:pharmacology* / Q000627:therapeutic use; D027843:Vitis / Q000737:chemistry*; D014920:Wine / Q000032:analysis*
D008078:Cholesterol, LDL; D005419:Flavonoids; D010636:Phenols; D011108:Polymers