title: Ultrustructural and enzymatic studies of rat liver after acute cadmium exposure.
abstract: The aim of the study was to examine morphological and enzymatic changes in the rat liver following single i.v. administration of CdCl2 (5 and 10 mumol/kg b.w.). In the rats given 5 and 10 mumol CdCl2/kg b.w., a correlation was found between the dose and the intensity of changes in the liver both in pathomorphological, ultrastructural and enzymatic analyses. Pathomorphological and ultrastructural investigations showed that a single dose of 10 mumol CdCl2/kg b.w. caused vacuolar degeneration, and fatty degeneration in single hepatocytes. Structural changes were accompanied by an increase in the activity of indicatory enzymes of the liver-AST and ALT. At the same time, stimulation and activation of B-K cells were observed. However, a single 5 mumol CdCl2/kg b.w. dose induced only blurring of cell structure in single hepatocytes within the peripheral zone of the lobules, which looked as if they had been filled with pinkish "mush".
authors.affiliation: Departments of Histology and Embryology, Clinical Pathomorphology, Medical Academy of Białystok, Białystok, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Czykier
authors.forename: Beata
authors.initials: B
authors.lastname: Szynaka
authors.forename: Janina
authors.initials: J
authors.lastname: Moniuszko-Jakoniuk
authors.forename: Bogusław
authors.initials: B
authors.lastname: Sawicki
mesh_terms: D000410:Alanine Transaminase / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000378:metabolism*; D019256:Cadmium Chloride / Q000494:pharmacology*; D002105:Cadmium Poisoning; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure*; D008107:Liver Diseases / Q000201:enzymology* / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008930:Mitochondria, Liver / Q000648:ultrastructure; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013053:Spectrophotometry
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D019256:Cadmium Chloride