title: [Study on the coagulation state of laryngeal cancer patients before and after operation].
abstract: OBJECTIVE
  To explore the coagulation state of laryngeal cancer patients before and after operation.
  
  
  METHODS
  The eight parameters of coagulant system of 46 laryngeal cancer patients were examined before operation, 1 day and 10 days after operation, and compared with control group.
  
  
  RESULTS
  The result suggests, anticoagulant activity decreased and fibrinolytic activity increased in laryngeal cancer patients before operation. Laryngectomy trauma may worsen the abnormality. With the incision of tumors and recovery from operation trauma, anticoagulant activity and fibrinolytic activity of the patients gradually returned to normal level.
  
  
  CONCLUSIONS
  Coagulation disorders in laryngeal cancer patients had existed in a way. With operation trauma, it may worsen the abnormality. So anticoagulant and fibrinolytic systems of these patients should be taken seriously to prevent thrombosis and bleeding.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital, Nangjing Medical University, Nangjing 210029.
authors.forename: W
authors.initials: W
authors.lastname: Dong
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000150:complications / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged