CD40 in hepatocellular carcinoma: relevant or not?
The expression of the CD40 receptor in different tumours suggests that it might be involved in tumour development and proliferation. In this article, we discuss recent findings on CD40 expression in hepatocellular carcinoma, its possible biological role for tumour development, and different experimental therapeutic strategies such as gene therapy and immunotherapy protocols.
Greten
Tim F
TF
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Pasteurallee 5, 30655 Hannover, Germany. greten.tim@mh-hannover.de
Ott
Michael
M
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis / Q000502:physiology; D019013:CD40 Antigens / Q000032:analysis / Q000502:physiology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D008024:Ligands; D008113:Liver Neoplasms / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D019013:CD40 Antigens; D008024:Ligands