title: [Multimodal treatment strategy for Langerhans cell histiocytosis at head and neck manifestations].
abstract: Langerhans cell histiocytosis (LCH) is a rare disorder with different clinical features. An established standardized treatment does not exist.We present a case report of a patient with localized LCH of the temporal bone and discuss the interdisciplinary treatment strategies. We reviewed the international literature and summarized the current knowledge. Beside a wait and see policy in cases without symptomatic disease, surgery, radiotherapy or chemotherapy, and combinations of these options are used as treatment modalities. While surgery or radiotherapy are preferred in localized (symptomatic) lesions, stage-adapted chemotherapeutic regimens are the treatments of choice in disseminated disease. Treatment selection depends on the individual clinical features.
authors.affiliation: Klinik für Radioonkologie und Strahlentherapie,Klinik am Eichert, Göppingen. Radioonkologie@KaE.de
authors.forename: G
authors.initials: G
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Bücheler
authors.forename: F
authors.initials: F
authors.lastname: Paulsen
authors.forename: C
authors.initials: C
authors.lastname: Denzlinger
authors.forename: C
authors.initials: C
authors.lastname: Belka
authors.forename: P K
authors.initials: PK
authors.lastname: Plinkert
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D004427:Ear Diseases / Q000175:diagnosis / Q000532:radiotherapy / Q000601:surgery*; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008416:Mastoid / Q000473:pathology / Q000601:surgery; D010348:Patient Care Team; D018714:Radiotherapy, Adjuvant; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed