[Purity analysis of cephalosporins with capillary zone electrophoresis].
A capillary zone electrophoresis method is proposed for the purity determination of nine cephalosporin drugs. A background electrolyte comprising of either 20 mmol/L pH 9.20 borate buffer or 20 mmol/L pH 6.86 phosphate buffer was used for most drugs studied except for cefaloridine which formed neutral molecules at these pH values. For it 50 mmol/L pH 2.05 phosphate buffer was used instead. Internal normalization method was employed for quantitation. The method is simple, rapid and versatile. Analysis was completed within 8 min. The merits and limitations of the method were also discussed.
Long
H
H
Department of Chemistry, Peking University, Beijing 100871, China.
Ding
Q
Q
Wang
T S
TS
Huang
A J
AJ
Sun
Y L
YL
D002437:Cefazolin / Q000032:analysis; D002439:Cefotaxime / Q000032:analysis; D002506:Cephalexin / Q000032:analysis; D002509:Cephaloridine / Q000032:analysis; D002511:Cephalosporins / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*
D002511:Cephalosporins; D002437:Cefazolin; D002509:Cephaloridine; D002439:Cefotaxime; D002506:Cephalexin