Progress in the control system of the undulation pump total artificial heart.
The undulation pump total artificial heart (UPTAH) is a small implantable total artificial heart. As the UPTAH generates outflow and inflow at the same time, control of the UPTAH is very difficult. Therefore suitable control methods specifically for the UPTAH should be established. Various motor control, left-right flow balance control, and physiological control methods were examined and tried for the UPTAH control in this study. The control system is divided into seven categories. It has a hierarchical structure and all control modes work at the same time. The UPTAH with the newly developed control method has been implanted into the chest cavities of 48 goats. Until now, six goats survived for more than one month, including 63 days in the longest case. The good condition of the UPTAH implanted animal could be maintained with the newly developed control scheme, consisting of the 1/R control and several other additional controls.
Saito
Itsuro
I
Research Center for Advanced Science and Technology, The University of Tokyo, Japan. saito@bme.rcast.u-tokyo.ac.jp
Chinzei
Tsuneo
T
Abe
Yusuke
Y
Ishimaru
Mitsuhiko
M
Mochizuki
Shuichi
S
Ono
Toshiya
T
Isoyama
Takashi
T
Iwasaki
Kiyotaka
K
Kouno
Akimasa
A
Baba
Atsushi
A
Ozeki
Toshinaga
T
Takiura
Koki
K
Tohyama
Takahiro
T
Nakagawa
Hidemoto
H
Imachi
Kou
K
D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D006041:Goats; D006331:Heart Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006354:Heart, Artificial / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology; D011183:Postoperative Complications; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000009:adverse effects*; D015996:Survival Rate