Serotonin syndrome: a reported case.
We describe a patient treated with SSRI and Ldopa, who developed agitation, rigidity, hyperreflexia, restlessness, autonomic instability, fever and finally death. CSF examination, MRI of the brain, laboratory investigations, except for serum CK, glycemia and WBC, were normal. His condition was thought to result from an central serotonin activity. The serotonin syndrome occurs following the use of serotomimetic agents (serotonin reuptake inhibitors, tricyclic and tetracyclic antidepressants, tryptophan alone or in combination with monoamine oxidase inhibitors).
Avarello
T P
TP
Department of Neurology, Villa Sofia Hospital, Palermo, Italy.
Cottone
S
S
D000368:Aged; D004344:Drug Incompatibility; D017809:Fatal Outcome; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D018490:Serotonin Agents / Q000008:administration & dosage / Q000009:adverse effects*; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects
D007980:Levodopa; D008996:Monoamine Oxidase Inhibitors; D018490:Serotonin Agents; D017367:Selective Serotonin Reuptake Inhibitors