Lymphangiogenesis new mechanisms.
A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.
Chang
Lynn
L
Department of Surgery, Harvard Medical School, and Surgical Research Laboratory, Children's Hospital, Boston, Massachusetts 02115, USA.
Kaipainen
Arja
A
Folkman
Judah
J
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D016510:Corneal Neovascularization / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D004195:Disease Models, Animal; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006801:Humans; D008206:Lymphatic Diseases / Q000503:physiopathology; D008208:Lymphatic System / Q000098:blood supply*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000503:physiopathology*
D020533:Angiogenesis Inhibitors; D016222:Fibroblast Growth Factor 2