title: Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis.
abstract: OBJECTIVE
  The purpose of the present study was to clarify the correlation between phenotypic expression of gastrointestinal differentiation markers and colorectal cancer behaviour, particularly invasion and hepatic metastasis.
  
  
  METHODS
  Thirty-one cases of advanced colorectal adenocarcinoma (CRC) with liver metastasis were selected. Phenotypic patterns were evaluated immunohistochemically by means of antibodies to CD10, MUC2, and human gastric mucin (HGM).
  
  
  RESULTS
  The incidence of MUC2 (45.2%) and HGM (16.1%) expression in CRCs with liver metastasis did not differ from non-metastatic CRCs. In contrast, the incidence of CD10 expression was significantly higher in CRCs with liver metastasis (58.1%) than in control CRCs (21.7%). Phenotypic expression in the liver metastasis carcinomas was similar to that of the primary lesions.
  
  
  CONCLUSIONS
  The findings suggest that cases of CRC with CD10 expression are at increased risk of liver metastasis. Even if there is no liver metastasis at laparotomy for CRC, careful follow-up is recommended for CRCs with CD10 expression.
authors.affiliation: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Miyuki
authors.initials: M
authors.lastname: Takata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Tustsumi
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Taguchi
authors.forename: Eishi
authors.initials: E
authors.lastname: Nagai
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000378:metabolism* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D015179:Colorectal Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005752:Gastric Mucins / Q000096:biosynthesis; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D055262:Mucin-2; D009077:Mucins / Q000096:biosynthesis; D015260:Neprilysin / Q000096:biosynthesis; D010641:Phenotype
chemical_list: D014408:Biomarkers, Tumor; D005752:Gastric Mucins; C524625:MUC2 protein, human; D055262:Mucin-2; D009077:Mucins; D015260:Neprilysin