A modified method for preparation of adriamycin carried by magnetic albumin microspheres.
The targeting of antineoplastic agents to restricted anatomic sites and specific target cells have been challenged clinicians all the time in cancer chemotherapy, which resulted in recent efforts to focus the effects of existing antitumor agents and treatments on tumor cells and spare their effects on normal cells. The drug-carrier complex, adriamycin carried by magnetic albumin microspheres (ADM-MAM) was prepared by using our discovered new and modified method. The physical feature of the prepared drug-carrier microspheres was much better than by the traditional method in comparison. The successful preparation of the drug-carrier complex, ADM-MAM, is one of the key steps for our later further researches in the targeted chemotherapy.
Ma
J
J
Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Chen
D
D
Tian
Y
Y
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D004333:Drug Administration Routes; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins; D008280:Magnetics; D008863:Microspheres; D010316:Particle Size; D004364:Pharmaceutical Preparations; D012709:Serum Albumin
D000970:Antineoplastic Agents; D004337:Drug Carriers; D000922:Immunotoxins; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D004317:Doxorubicin