title: Acute blindness as a presenting sign in childhood non-Hodgkin lymphoma.
abstract: Non-Hodgkin lymphoma is the third most common malignancy in childhood. Occasionally, a patient with lymphoma may present with neuroophthalmologic symptoms and signs. It is usually associated with 3rd, 4th, and 6th cranial nerve palsies. Here, we report three children presenting with loss of vision. Two of them were cured with modified LMB-89 (lymphoma malignant B) chemotherapy regimen and radiotherapy. In one patient, loss of vision returned to normal in the left eye but persisted in the right eye. The second patient suffered from permanent visual loss, although the primary disease responded well to treatment. Unfortunately, the third patient died at an early phase of treatment. Acute blindness as a presenting symptom is rare in lymphoma. Early diagnosis and treatment is critical to increase the survival rate and to improve the quality of the vision.
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Institute of Oncology, 06100 Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Güler
authors.forename: Tezer
authors.initials: T
authors.lastname: Kutluk
authors.forename: Nejat
authors.initials: N
authors.lastname: Akalan
authors.forename: Canan
authors.initials: C
authors.lastname: Akyüz
authors.forename: Lale
authors.initials: L
authors.lastname: Atahan
authors.forename: Münevver
authors.initials: M
authors.lastname: Büyükpamukçu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001766:Blindness / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D018714:Radiotherapy, Adjuvant