title: A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report.
abstract: An immunocompetent 29-year-old male presented with an embolic stroke from an unusual primary cardiac lymphoma. The cardiac lesion consisted of a polypoid, left atrial, mural fibrin thrombus with anaplastic tumor cells lining the surface of the clot. Histologic, immunophenotypic, and molecular characterizations were consistent with a diagnosis of CD30+ large B-cell lymphoma with anaplastic cytology. While tumor emboli from invasive primary cardiac lymphomas have been reported, this noninvasive fibrin thrombus-associated lymphoma appears to be unique and previously unreported.
authors.affiliation: Department of Pathology, Division of Cardiology, Naval Medical Center, San Diego, CA 92134, USA. mmquigley@nmcsd.med.navy.mil
authors.forename: Michael M
authors.initials: MM
authors.lastname: Quigley
authors.forename: Eric
authors.initials: E
authors.lastname: Schwartzman
authors.forename: Pamela D
authors.initials: PD
authors.lastname: Boswell
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Christensen
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Gleason
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sharpe
authors.forename: Thomas A
authors.initials: TA
authors.lastname: D'Amato
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005337:Fibrin / Q000032:analysis; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D020766:Intracranial Embolism / Q000209:etiology*; D017730:Ki-1 Antigen / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009232:Myxoma; D010976:Platelet Count; D020521:Stroke / Q000209:etiology*; D014463:Ultrasonography
chemical_list: D017730:Ki-1 Antigen; D005337:Fibrin