[Expression and significance of urokinase-type plasminogen activator in medulloblastoma].
OBJECTIVE
To detect the expression and evaluate the clinical significance of urokinase-type plasminogen activator (uPA) in medulloblastoma.


METHODS
LSAB (labelled streptavidin biotin method) immunohistochemical technique was applied for detecting the expression of uPA in 50 patients with medulloblastoma, and a follow-up survey with Cox regression analysis was made.


RESULTS
The staining for uPA was localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA was an independent prognostic factor affecting survival and it had a negative correlation with the prognosis.


CONCLUSIONS
uPA appears to be an independent marker for predicting the prognosis of medulloblastoma.
Wang
Y
Y
Department of Neurosurgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Mao
B
B
Zhang
S
S
Cheng
H
H
D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000201:enzymology*; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis* / Q000235:genetics
D014568:Urokinase-Type Plasminogen Activator