[Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population].
OBJECTIVE
To study the Mitochondrial DNA 7445A-->G mutation in nonsyndromic deafness patients in Chinese population.


METHODS
Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to screen the mitochondrial DNA 7445A-->G mutation among 128 nonsyndromic deafness individuals from 32 pedigrees, 135 sporadic nonsyndromic deafness patients and 100 normal subjects.


RESULTS
The 7445A-->G mutation did not appear in the experiment.


CONCLUSIONS
Incidence of the mitochondrial 7445A-->G mutation was lower than that of mtDNA 1555A-->G mutation in nonsyndromic deafness patients in China.
Liu
Y H
YH
First Hospital, Beijing Medical University, Beijing 100034.
Ke
X M
XM
Qi
Y
Y
Xu
H B
HB
Gu
Z P
ZP
Liu
X C
XC
Liu
J F
JF
D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male
D004272:DNA, Mitochondrial