title: Progress in the control system of the undulation pump total artificial heart.
abstract: The undulation pump total artificial heart (UPTAH) is a small implantable total artificial heart. As the UPTAH generates outflow and inflow at the same time, control of the UPTAH is very difficult. Therefore suitable control methods specifically for the UPTAH should be established. Various motor control, left-right flow balance control, and physiological control methods were examined and tried for the UPTAH control in this study. The control system is divided into seven categories. It has a hierarchical structure and all control modes work at the same time. The UPTAH with the newly developed control method has been implanted into the chest cavities of 48 goats. Until now, six goats survived for more than one month, including 63 days in the longest case. The good condition of the UPTAH implanted animal could be maintained with the newly developed control scheme, consisting of the 1/R control and several other additional controls.
authors.affiliation: Research Center for Advanced Science and Technology, The University of Tokyo, Japan. saito@bme.rcast.u-tokyo.ac.jp
authors.forename: Itsuro
authors.initials: I
authors.lastname: Saito
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Chinzei
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Ishimaru
authors.forename: Shuichi
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ono
authors.forename: Takashi
authors.initials: T
authors.lastname: Isoyama
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Akimasa
authors.initials: A
authors.lastname: Kouno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Baba
authors.forename: Toshinaga
authors.initials: T
authors.lastname: Ozeki
authors.forename: Koki
authors.initials: K
authors.lastname: Takiura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tohyama
authors.forename: Hidemoto
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Kou
authors.initials: K
authors.lastname: Imachi
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D006041:Goats; D006331:Heart Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006354:Heart, Artificial / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology; D011183:Postoperative Complications; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000009:adverse effects*; D015996:Survival Rate