[Separation and determination of the ingredients of cold medicines by capillary electrophoresis with amperometric detection].
Determination and separation of three ingredients--chlorphenamine maleate, acetaminophen and vitamin C in cold medicines by capillary electrophoresis with amperometric detection were carried out. The effects of detection potential and organic modifier were extensively investigated. Separation efficiency could be improved by adding 1, 2-propanediol into buffer. On optimizing condition, chlorphenamine maleate, acetaminophen and vitamin C were separated satisfactorily and eluted within 12 min. The detection limits were 0.02, 0.08 and 0.01 mg/L respectively. The ingredients in several cold medicines were detected successfully. The recoveries of the samples were 94.2%-102.8%. The method is simple, rapid and highly reliable for routine analysis.
Yang
B
B
School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, China.
Mo
J
J
Yang
X
X
Wang
L
L
D000082:Acetaminophen / Q000032:analysis / Q000302:isolation & purification*; D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000302:isolation & purification; D018926:Anti-Allergic Agents / Q000032:analysis / Q000302:isolation & purification; D001205:Ascorbic Acid / Q000032:analysis / Q000302:isolation & purification*; D002744:Chlorpheniramine / Q000032:analysis / Q000302:isolation & purification*; D004339:Drug Compounding; D019075:Electrophoresis, Capillary / Q000379:methods*
D018712:Analgesics, Non-Narcotic; D018926:Anti-Allergic Agents; D000082:Acetaminophen; D002744:Chlorpheniramine; D001205:Ascorbic Acid