Effects of cilazapril on endothelial function and pulmonary hypertension in patients with congestive heart failure.
Flow-mediated vasodilation (FMV), brachial artery flow (BAF), and brachial artery diameter were evaluated in 30 patients with congestive heart failure before and after cilazapril treatment. While mean pulmonary artery pressure and pulmonary capillary wedge pressure decreased significantly, flow-mediated vasodilation and left ventricular ejection fraction increased significantly following cilazapril administration (P < 0.001). Brachial artery diameter and brachial artery flow did not change following the treatment period (P > 0.05). In conclusion, short-term cilazapril administration improved endothelial function and pulmonary pressure in patients with congestive heart failure.
Tavli
Talat
T
Department of Cardiology, Celal Bayar University, School of Medicine, Zubeyde Hanim Cad. 39-1, Karsiyaka, Izmir, Turkey.
Gocer
Hakan
H
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001775:Blood Circulation / Q000187:drug effects; D001916:Brachial Artery / Q000502:physiology; D017315:Cilazapril / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014664:Vasodilation
D000806:Angiotensin-Converting Enzyme Inhibitors; D017315:Cilazapril