Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
This review summarizes recent findings and common principles for intramembrane-cleaving proteases that catalyse critical steps in cell regulation and signalling and which are involved in diseases such as Alzheimer's disease and hepatitis C virus infection.
Weihofen
Andreas
A
Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), ETH-Hoenggerberg, 8093 Zurich, Switzerland.
Martoglio
Bruno
B
D000818:Animals; D020134:Catalytic Domain / Q000502:physiology; D002462:Cell Membrane / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D006868:Hydrolysis; D007425:Intracellular Membranes / Q000201:enzymology*; D008565:Membrane Proteins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D053764:Presenilin-1
D008565:Membrane Proteins; C508853:PSEN1 protein, human; D010455:Peptides; D053764:Presenilin-1; D010450:Endopeptidases; D008666:Metalloendopeptidases; C120654:MBTPS2 protein, human