New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.
Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.
Uchiyama
Nahoko
N
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Kiuchi
Fumiyuki
F
Ito
Michiho
M
Honda
Gisho
G
Takeda
Yoshio
Y
Khodzhimatov
Olimjon K
OK
Ashurmetov
Ozodbek A
OA
D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
D004224:Diterpenes; D014344:Trypanocidal Agents