[Relationship between basic fibroblast growth factor (bFGF) and cell proliferation, invasion in pituitary adenoma].
Basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) were examined by immunohistochemistry in fifty-one pituitary adenomas. The results showed that the intensity of bFGF expression was strong or intermediate in twenty-nine adenomas, which was positively related to cell proliferation, there was positive relationship between bFGF expressin and tumor invasion in non-functional adenomas. The data suggest that bFGF may play some role in the origin and progression of pituitary adenomas.
Wen
L
L
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen
L
L
Liu
Y S
YS
D000236:Adenoma / Q000737:chemistry* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002455:Cell Division; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000737:chemistry* / Q000473:pathology
D014408:Biomarkers, Tumor; D016222:Fibroblast Growth Factor 2