[Immunological changes after the Ross operation].
The aim of present paper is to analyze immunological changes due to Ross operation. Cellular immune response as well as incidence of antibodies directed against human leukocyte antigens were studied in patients who received cardiac valve allografts. Standard microlymphocytotoxicity test was used to determine the percentage of panel reactive antibodies. Activated lymphocyte response to Pokeweed mitogen was revealed in patients after Ross operation. The panel reactive antibodies became positive in 3 out of 6 recipients tested. This production of donor specific anti-HLA antibodies can contribute to graft failure in case of subsequent cardiac transplantation.
Malickaite
Radvile
R
Heart Surgery Center, Vilnius University, Santariskiu 2, 2021 Vilnius, Lithuania. radvile.malickaite@santa.lt
Staneviciene
Aldona
A
Dranenkiene
Alicija
A
Sudikiene
Rita
R
D000293:Adolescent; D000328:Adult; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000276:immunology; D006351:Heart Valves / Q000276:immunology / Q000637:transplantation*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D011043:Pokeweed Mitogens / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology*
D006680:HLA Antigens; D011043:Pokeweed Mitogens