title: Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines.
abstract: [reaction: see text] To improve upon the previous orthogonal method for synthesis of a triazine library, an alternative strategy has been developed via oxidation-activation of the thioether to the sulfone. Through a comparison between these two methods, the sulfone strategy was demonstrated as an enhanced method in the generation of highly pure triazine library compounds.
authors.affiliation: Department of Chemistry, New York University, New York, New York 10003, USA.
authors.forename: Jacqueline T
authors.initials: JT
authors.lastname: Bork
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Sonya M
authors.initials: SM
authors.lastname: Khersonsky
authors.forename: Ho-Sang
authors.initials: HS
authors.lastname: Moon
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D020650:Combinatorial Chemistry Techniques; D012117:Resins, Synthetic; D014227:Triazines / Q000138:chemical synthesis*; D050257:Tubulin Modulators
chemical_list: D012117:Resins, Synthetic; D014227:Triazines; D050257:Tubulin Modulators