title: [Clinical observation of combined therapeutic effect of prostaglandin E1 and mecobalamin on diabetic peripheral neuropathy].
abstract: OBJECTIVE
  To observe the clinical effect of combined treatment of prostaglandin E1 and mecobalamin on diabetic peripheral neuropathy(DPN).
  
  
  METHODS
  Seventy two patients of DPN were divided into 3 groups, they were given the drug of prostaglandin E1 (PGE1), mecobalamin, PGE1 plus mecobalamin (combined therapeutic group) and compared the therapeutic effects respectively.
  
  
  RESULTS
  The improvement of DPN symptoms and nerve conducting speeds of combined therapeutic group was obviously better than that of the single PGE1 group or mecobalamin group(P < 0.01).
  
  
  CONCLUSIONS
  Combined therapy of PGE1 and mecobalamin is better than each of single drug for improvement of DPN symptoms.
authors.affiliation: Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Zhu
authors.forename: Z G
authors.initials: ZG
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: C019476:mecobalamin; D000527:Alprostadil; D014805:Vitamin B 12