[Application of Ca(2+)-ISME in the studies on pharmacokinetics of calcium supplements].
OBJECTIVE
To determined the concentration of Ca2+ in serum by a self-made Ca(2+)-ISME in order to indicate the absorption of calcium supplement.


METHODS
We have developed a calibration curve method to measure Ca2+ activities in serum sample. The pharmacokinetics of three kinds of calcium supplements were investigated by the Ca(2+)-ISME after P.O. administration in 5 healthy rats.


RESULTS
Though the Tmax (hours) of the three kinds of preparations were different, there were no significant differences among their AUC by paired t-text.


CONCLUSIONS
The above results demonstrate that our self-made Ca(2+)-ISME is applicable to the researches on pharmacokinetics of calcium supplements.
Yang
H
H
School of Pharmaccology, WCUMS, Chengdu 610041, China.
Lü
T
T
Jiang
Y
Y
D000818:Animals; D002118:Calcium / Q000097:blood / Q000493:pharmacokinetics*; D019587:Dietary Supplements; D005260:Female; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017208:Rats, Wistar
D002118:Calcium