title: [The effect of rIFN alpha-2b on mice NK cell activity].
abstract: OBJECTIVE
  This animal experiment was made to study the effect of the recombined interferon alpha-2b(rIFN alpha-2b) on natural killer cells activity of mice spleen in vivo, and by way of this, to test the activity of rIFN alpha-2b.
  
  
  METHODS
  BALB/c mice were given rIFN alpha-2b subcutaneously. The inhibiting 3H-TdR intaking method was used to test the NK activity of spleen cells of BALB/c mice.
  
  
  RESULTS
  The NK cell activity levels of the high-dose group, the mid-dose group and the low-dose group were 65.19 +/- 17.56, 44.19 +/- 14.30 and 35.46 +/- 17.49, respectively.
  
  
  CONCLUSIONS
  rIFN a-2b can enhance NK cells activity observably and its effect is dose dependent.
authors.affiliation: Department of Immunology, WCUMS, Chengdu 610041, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Cai
mesh_terms: D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D005260:Female; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D011994:Recombinant Proteins; D013154:Spleen / Q000276:immunology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins