title: High-frequency electrical stimulation of the subthalamic nucleus in Parkinson's disease: kinetic and kinematic gait analysis.
abstract: In the advanced phase of Parkinson's disease (PD), gait disturbances represent one of the main causes of disability. Several studies demonstrated that high-frequency electrical stimulation (HFS) of the subthalamic nucleus (STN) significantly improves the motor symptoms of PD. This study was finalised to quantitatively analyze the effect of STN HFS on gait of PD patients, through a three-dimensional gait analysis system. Ten PD patients were studied, with and without STN HFS. The results demonstrated that STN HFS significantly improves all the main gait parameters in PD patients.
authors.affiliation: U.O.A. of Neurology, ASL 19, Asti, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rizzone
authors.forename: M
authors.initials: M
authors.lastname: Ferrarin
authors.forename: A
authors.initials: A
authors.lastname: Pedotti
authors.forename: B
authors.initials: B
authors.lastname: Bergamasco
authors.forename: E
authors.initials: E
authors.lastname: Bosticco
authors.forename: M
authors.initials: M
authors.lastname: Lanotte
authors.forename: P
authors.initials: P
authors.lastname: Perozzo
authors.forename: A
authors.initials: A
authors.lastname: Tavella
authors.forename: E
authors.initials: E
authors.lastname: Torre
authors.forename: M
authors.initials: M
authors.lastname: Recalcati
authors.forename: A
authors.initials: A
authors.lastname: Melcarne
authors.forename: L
authors.initials: L
authors.lastname: Lopiano
mesh_terms: D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D004599:Electric Stimulation Therapy; D005260:Female; D005684:Gait; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology