title: Systolic blood pressure is the main etiology for poorly controlled hypertension.
abstract: BACKGROUND
  Isolated systolic hypertension is an important risk factor for cardiovascular events. The purpose of this study was to detect the prevalence of and to evaluate the effectiveness of currently available medications in the treatment of uncontrolled isolated systolic hypertension.
  
  
  METHODS
  We randomly selected a total of 585 patients with hypertension from our database. The two most recent blood pressure (BP) readings and other data were obtained by chart review.
  
  
  RESULTS
  Of 585 patients, 340 (58%) had controlled BP. Of 245 patients with uncontrolled hypertension, 77.1% had uncontrolled isolated systolic hypertension and the remaining 22.9% had uncontrolled diastolic hypertension. Patients with uncontrolled systolic hypertension were on average taking more antihypertensive medications than patients with controlled BP (2.10 +/- 0.09; P = .034).
  
  
  CONCLUSIONS
  Systolic hypertension is the etiology of uncontrolled hypertension in the majority of patients. Currently available antihypertensive medications are less effective in controlling systolic hypertension.
authors.affiliation: Division of Nephrology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA. alammuhammad@uams.edu
authors.forename: Muhammad G
authors.initials: MG
authors.lastname: Alam
authors.forename: Yousri M
authors.initials: YM
authors.lastname: Barri
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008875:Middle Aged; D012189:Retrospective Studies; D013599:Systole; D017211:Treatment Failure
chemical_list: D000959:Antihypertensive Agents