Using genome-wide mapping in the mouse to identify genes that influence drug response.
Differential drug response is most often likely to be a complex trait, controlled by the combined influences of multiple genes and environmental influences. As a result of theoretical and technical limitations, to date, most clinically useful pharmacogenomic studies in humans have been limited to a small number of candidate genes that have a relatively major impact on drug response. Here, the problems involved in identifying genes that underlie drug response in humans are discussed and the power of mouse genetics as a tool for pharmacogenomic discovery is highlighted.
Watters
James W
JW
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
McLeod
Howard L
HL
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D006801:Humans; D051379:Mice; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010597:Pharmacogenetics / Q000379:methods*; D013045:Species Specificity
D004364:Pharmaceutical Preparations