title: Helicobacter pylori gastritis in children: endoscopical and histological aspects.
abstract: Helicobacter pylori (Hp) infection is involved in both digestive and extradigestive diseases. Endoscopically, antral location of gastritis, as well as antral nodularity, a consequence of the development of lymphoid follicles in the mucosa of this area, are considered by some authors specific for gastritis in children. Histologically, lymphoid follicles, noticed usually in children, are considered pathognomonic.
  
  
  OBJECTIVE
  To establish prevalence of gastritis in children and the correlation between of endoscopical and histological findings.
  
  
  METHODS
  The study group included 267 children in whom upper digestive endoscopy was performed for digestive symptoms. The diagnosis of Hp infection was based on the concordance between the positive urease test and the histological examination (documenting the presence of Hp in the gastric mucosa).
  
  
  RESULTS
  Endoscopical aspect of antral nodular gastritis was mainly found in children infected with Hp. Follicular gastritis, considered the histological marker of nodular gastritis, was also revealed in congestive gastritis. Patients infected with Hp most often displayed chronic gastritis and noninfected patients acute gastritis. Hp was not found in gastric mucosa without histological changes.
  
  
  CONCLUSIONS
  Nodular pattern of antral mucosa might be considered specific for Hp infection in childhood. In patients infected with Hp chronic gastritis was mainly found while in noninfected children acute gastritis was usually revealed. Hp was not found in gastric mucosa without histological changes.
authors.affiliation: 1st Pediatric Clinic, University of Medicine and Pharmacy, Str. Motilor no. 68, 3400 Cluj-Napoca, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Serban
authors.forename: Paula
authors.initials: P
authors.lastname: Grigorescu-Sido
authors.forename: Dan
authors.initials: D
authors.lastname: Gheban
authors.forename: Eva
authors.initials: E
authors.lastname: Kiss
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D015995:Prevalence; D014510:Urease / Q000032:analysis
chemical_list: D014510:Urease