Reverse seroconversion of hepatitis B virus after hematopoietic stem cell transplantation.
Hepatitis B virus (HBV) reactivation in patients previously positive for hepatitis B surface antibody (HBsAb), so-called reverse seroconversion, has been considered to be a rare complication after hematopoietic stem cell transplantation (HSCT). We experienced two patients who developed reverse seroconversion among nine who were HBsAb positive and Hepatitis B core antibody (HBcAb) positive before HSCT; one after autologous bone marrow transplantation (BMT) and another after allogeneic peripheral blood stem cell transplantation (PBSCT). We reviewed the literature and considered that reverse seroconversion of HBV after HSCT is not uncommon among HBsAb positive recipients. The use of corticosteroids, the lack of HBsAb in donor, and a decrease in serum HBsAb and HBcAb levels may predict reverse seroconversion after HSCT.
Goyama
S
S
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Kanda
Y
Y
Nannya
Y
Y
Kawazu
M
M
Takeshita
M
M
Niino
M
M
Komeno
Y
Y
Nakamoto
T
T
Kurokawa
M
M
Tsujino
S
S
Ogawa
S
S
Aoki
K
K
Chiba
S
S
Motokura
T
T
Shiratori
Y
Y
Hirai
H
H
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006509:Hepatitis B / Q000139:chemically induced; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014775:Virus Activation / Q000187:drug effects*
D000305:Adrenal Cortex Hormones; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens