RNA as a drug target.
In the antiviral and antibacterial area, increasing drug resistance means that there is an ever growing need for novel approaches towards structures and mechanisms which avoid the current problems. The huge increase in high resolution structural data is set to make a dramatic impact on targeting RNA as a drug target. The examples of the RNA binding antibiotics, particularly, the totally synthetic oxazolidinones, should help persuade the skceptics that clinically useful, selective drugs can be obtained from targeting RNA directly.
Drysdale
Martin J
MJ
Department of Chemistry, RiboTargets Ltd., Granta Park, Abington, Cambridge, CB1 6GB, UK.
Lentzen
Georg
G
Matassova
Natalia
N
Murchie
Alastair I H
AI
Aboul-Ela
Fareed
F
Afshar
Mohammad
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D009690:Nucleic Acid Conformation; D011500:Protein Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000187:drug effects; D012335:RNA, Ribosomal / Q000187:drug effects*; D012367:RNA, Viral / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D011500:Protein Synthesis Inhibitors; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D012367:RNA, Viral