title: A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes.
abstract: [reaction: see text] A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.
authors.affiliation: Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, 91 128 Palaiseau Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Bacqué
authors.forename: François
authors.initials: F
authors.lastname: Pautrat
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D003508:Cycloheptanes / Q000138:chemical synthesis* / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds; D000097567:Pleuromutilins
chemical_list: D003508:Cycloheptanes; D004224:Diterpenes; D011083:Polycyclic Compounds; D000097567:Pleuromutilins