title: Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands.
abstract: Autistic probands exhibit impaired spatial accuracy and impaired response suppression errors during a delayed oculomotor response task. Family members of autistic probands, and thus the possible familial nature of these deficits, have not been assessed. Eleven parents of autistic probands and 17 adults from unaffected families, ages 25-50 years, completed oculomotor delayed-response tasks. Parents of autistic probands demonstrated poorer spatial accuracy than the comparison group (p = .002), with no significant differences between groups on percentage of premature saccades or latency of remembered saccades. Spatial working memory deficits, as measured by the delayed oculomotor response task, appear to be familial in families with an autistic proband. These deficits deserve further evaluation as a potential endophenotypic marker for genetic risk for autism.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
authors.forename: Dianne L
authors.initials: DL
authors.lastname: Koczat
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Rogers
authors.forename: Bruce F
authors.initials: BF
authors.lastname: Pennington
authors.forename: Randal G
authors.initials: RG
authors.lastname: Ross
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology* / Q000235:genetics; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D010290:Parents / Q000523:psychology*; D010641:Phenotype; D011930:Reaction Time; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors