Protective effect of enterosgel on rat liver lysosomes during cytostatic treatment.
Polychemotherapy with a complex of cytostatics (cyclophosphamide, doxorubicin, vincristine, prednisolone) induces progressive damage to hepatocyte membranes, which manifested in labilization of lysosomes and activation of lysosomal enzymes and serum transaminases. Enterosgel stabilized liver lysosomes and reduced manifestation of hepatocyte cytolysis.
Grek
O R
OR
Department of Pharmacology, Central Research Laboratory, Novosibirsk State Medical Academy.
Mishenina
S V
SV
Pupyshev
A B
AB
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000008:administration & dosage / Q000494:pharmacology*; D016060:Sorption Detoxification; D013997:Time Factors
D000970:Antineoplastic Agents; D005782:Gels; D012828:Silicones; C078211:polymethylsiloxane