Structure and mechanism of the oestrogen receptor.
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.
Kong
E H
EH
Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK.
Pike
A C W
AC
Hubbard
R E
RE
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000502:physiology*; D020218:Response Elements; D015533:Transcriptional Activation
D020033:Protein Isoforms; D011960:Receptors, Estrogen