title: In vitro and in vivo models for assessing drug efflux transporter activity.
abstract: Determining the activity of drug efflux transport proteins has important implications in the identification of substrates and/or inhibitors of the various transport systems, as well as mechanistic determination of localization, and functional role of the transporters in absorption, distribution and elimination of compounds in the body. This review examines both in vitro and in vivo approaches used to determine drug efflux transporter activity, their applications, and advantages and potential limitations.
authors.affiliation: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Corbin
authors.initials: C
authors.lastname: Bachmeier
authors.forename: Donald W
authors.initials: DW
authors.lastname: Miller
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D030801:Animals, Genetically Modified; D001693:Biological Transport, Active; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011922:Rats, Mutant Strains
chemical_list: D018528:ATP-Binding Cassette Transporters; D004364:Pharmaceutical Preparations