title: Langerhans' cell histiocytosis diagnosed through periodontal lesions: a case report.
abstract: BACKGROUND
  Langerhans' cell histiocytosis (LCH) is a rare disorder in which a neoplastic proliferation of cells similar to the Langerhans' cell of the epidermis is observed. The disease may affect different organs as solitary or multiple lesions with a complete dissemination in different organs such as the bone (jaws), lung, hypothalamus, skin and mucous membranes, lymph nodes, liver, and other tissues. Although LCH is considered a childhood or juvenile disease, the diagnosis is often made in adults, and in many cases, a juvenile form progresses into adult life. Hand-Schuller-Christian disease (HSCD) is an LCH form in which the typical lesions Involve the cranial bones, the eyes, and the pituitary gland.
  
  
  METHODS
  This article describes a case of a patient diagnosed, through periodontal lesions and diabetes insipidus, as having Langerhans' cell histiocytosis.
  
  
  CONCLUSIONS
  As far as LCH lesions appearing in periodontal tissues, the periodontist should be involved in the detection of oral lesions.
authors.affiliation: Department of Odontology and Stomatology, University of Florence, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Muzzi
authors.forename: Giovan Paolo
authors.initials: GP
authors.lastname: Pini Prato
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ficarrat
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000175:diagnosis / Q000209:etiology*; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D008336:Mandibular Diseases / Q000175:diagnosis / Q000209:etiology; D008963:Molar