Electrostatic fasteners hold the T cell receptor-CD3 complex together.
Assembly of the T cell receptor includes the formation of trimers stabilized by electrostatic interactions inside the membrane (Call et al., 2003). Such interactions can strongly stabilize subunit associations while permitting conformation changes during signaling.
Engelman
Donald M
DM
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
D017252:CD3 Complex / Q000737:chemistry* / Q000276:immunology; D046911:Macromolecular Substances; D008958:Models, Molecular; D011487:Protein Conformation; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000737:chemistry* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000276:immunology; D015398:Signal Transduction; D055672:Static Electricity
D017252:CD3 Complex; D046911:Macromolecular Substances; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011948:Receptors, Antigen, T-Cell