[Analysis of eosinophilia and ECP levels in blood and nasal secretions of 119 nasal polyposis patients].
OBJECTIVE
The aim of this prospective study was to determine eosinophilia and ECP (Eosinophilic Cationic Protein) levels in blood and in nasal secretions of patients with nasal polyposis (NP).


METHODS
119 patients with NP were prospectively studied. The control group included 25 patients.


METHODS
They included: questionnaire about asthma and intolerance to aspirin; nasal endosopic grading; nasal symptoms scoring; allergy testing; measurements of serum and nasal values of eosinophilia expressed as a percentage; measurements of serum and nasal values of ECP expressed in ng/ml; the Spearman correlation test, the T series and Khideux tests were used in the statistical analysis.


RESULTS
In NP group, 66 were asthmatic (As) and 53 non asthmatics (NAs), 40 were atopic (ATo), and 79 were non atopic (NAto). Values of nasal eosinophilia and nasal ECP in NP patients were significantly higher (respectively 40.7+/-35.6% and 22.8+/-48.0 ng/ml) than the control group (respectively 3.0+/-14% and 2.1+/-3.6 ng/ml). Nasal and serum eosinophilia values in asthmatic patients (As) (respectively 47+/-36% and 7.6+/-6.3%) were significantly higher (p<0.05) than in non asthmatic patients (NAs) (respectively 32.6+/-33.8% and 4.6+/-3.1%). No difference was found in nasal and serum ECP values between asthmatic and non asthmatic patients. Nasal eosinophilia values were significantly correlated (p=0.02) with nasal scoring in NP patients. No correlation was found between nasal ECP and serum ECP values and clinical scoring.


CONCLUSIONS
Nasal eosinophilia and nasal ECP values are significantly increased in NP. Nasal eosinophilia seems to be a relevant biological marker of clinical severity (association with asthma and a high clinical score) in NP patients. By contrast, nasal ECP cannot be consider as a marker of clinical severity.
Advenier
D
D
Service d'ORL et de Chirurgie de la face et du cou, Centre Hospitalier Universitaire, BP 69, 63003 Clermont-Ferrand Cedex 1.
Guichard
Ch
Ch
Kémény
J-L
JL
Tridon
A
A
Gilain
L
L
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D047091:Eosinophil Granule Proteins; D004802:Eosinophilia / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D009298:Nasal Polyps / Q000097:blood / Q000378:metabolism*; D011446:Prospective Studies; D012260:Ribonucleases; D011795:Surveys and Questionnaires
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases