title: Seasonal variation of the lipoidal matters and hypolipidaemic activity of the red alga Corallina officinalis L.
abstract: The lipoidal matters of Corallina officinalis L. showed a seasonal nonsignificant quantitative variation. However, the fatty acids revealed a relative increase in the summer and winter, while unsaponifiable matter exhibited a slight increase in the spring. The GC/MS analysis of saponifiable and unsaponifiable matter of the algal samples collected in different seasons revealed that samples collected in the spring contained a low cholesterol content and high steroidal compounds as well as high polyunsaturated fatty acids. The alcohol extract, hexane extract and fatty acid fraction of this algal sample exhibited a significant hypolipidaemic activity. Also, two biologically active fractions of hydrocarbons were isolated by CC technique from the hexane fraction of C. officinalis L. and identified by GC/MS.
authors.affiliation: Pharmacognosy and Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt.
authors.forename: N E
authors.initials: NE
authors.lastname: Awad
authors.forename: M A
authors.initials: MA
authors.lastname: Selim
authors.forename: M M
authors.initials: MM
authors.lastname: Saleh
authors.forename: A A
authors.initials: AA
authors.lastname: Matloub
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000187:drug effects; D008078:Cholesterol, LDL / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000032:analysis*; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D000461:Rhodophyta; D012621:Seasons; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol