The forkhead transcription factor Foxo1: a possible link between obesity and insulin resistance.
The forkhead transcription factor Foxo1 has previously been shown to be a mediator of insulin action in liver and pancreas. New data from demonstrate that it also functions in adipose cells to couple insulin signaling to adipogenesis, which involves switching preadipocytes from proliferation to terminal differentiation.
Farmer
Stephen R
SR
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
D017667:Adipocytes / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; D007328:Insulin; D014157:Transcription Factors