[Endogenous descending inhibitory/facilitatory system and serotonin (5-HT) modulating spinal nociceptive transmission].
Endogenous descending inhibitory system plays an important role in the modulation of nociceptive transmission. In recent years, descending facilitatory system has been noted. CNS bi-directionally modulates the peripheral nociceptive transmission at the spinal cord level via the descending inhibitory/facilitatory system. Serotonin (5-HT) is the main neurotransmitter in descending pain modulation. Intrathecal application of 5-HT or electrical stimulation or glutamate microinjection into the nucleus raphe magnus (NRM) and nucleus reticularis gigantocellularis(NGC) may produce inhibition and/or facilitation of spinal nociceptive transmission. The contradictory results may be attributed to the nonselective action(s) of 5-HT at multiple subtypes of 5-HT receptor in spinal cord.
Zhang
Y Q
YQ
State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031.
Wu
G C
GC
D000818:Animals; D006801:Humans; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission
D011985:Receptors, Serotonin; D012701:Serotonin