title: Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients.
abstract: OBJECTIVE
  To correlate the susceptibility of low-(LDL) and very-low-density lipoprotein to oxidation in vitro and the concentrations of serum antibodies against malondialdehyde-modified LDL and plasma vitamin E with the anthropometric and laboratory characteristics of obesity.
  
  
  METHODS
  A total of 75 nondiabetic, normotensive obese patients were assigned to one of four groups according to their body mass index (BMI): moderately obese (30 <or= BMI <or= 34.9 kg/m(2), n = 11), severely obese (35 <or= BMI <or= 39.9 kg/m(2), n = 20), morbidly obese (40 <or= BMI <or= 50 kg/m(2), n = 29), and very severely obese (BMI > 50 kg/m(2), n = 15).
  
  
  RESULTS
  The oxidation lag time for LDL from patients with a BMI >or=35 kg/m(2) was shorter than that for LDL from non-obese controls (n = 13), whereas very-low-density lipoprotein oxidation lag times were not significantly different. The serum antibodies against modified LDL were similar in all groups, whereas the plasma vitamin E concentrations of obese patients were decreased (p <or= 0.01). There was a negative correlation between LDL oxidation lag time and BMI (r = -0.35, p = 0.0008), and between plasma vitamin E and BMI (r = -0.53, p < 0.0001) and waist-to-hip ratio (r = -0.40, p = 0.0003).
  
  
  CONCLUSIONS
  The LDL of nondiabetic, normotensive obese patients is more readily oxidized, and plasma vitamin E concentrations are low. These are both risk factors for coronary heart disease.
authors.affiliation: INSERM U 430, Broussais Hospital, and Claude Bernard Association, Paris, France.
authors.forename: Isaac
authors.initials: I
authors.lastname: Myara
authors.forename: Catherine
authors.initials: C
authors.lastname: Alamowitch
authors.forename: Odile
authors.initials: O
authors.lastname: Michel
authors.forename: Didier
authors.initials: D
authors.lastname: Heudes
authors.forename: Jean
authors.initials: J
authors.lastname: Bariety
authors.forename: Bernard
authors.initials: B
authors.lastname: Guy-Grand
authors.forename: Jacques
authors.initials: J
authors.lastname: Chevalier
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000906:Antibodies / Q000097:blood; D001824:Body Constitution; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000737:chemistry; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood / Q000276:immunology; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D000906:Antibodies; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D014810:Vitamin E; D008315:Malondialdehyde; D003300:Copper; D002784:Cholesterol