[Fraction P isolated from the ribosomes of Serratia odorifera and its tumor inhibiting effect].
A protein(component P) with molecular weight of 16 kD was isolated by the method of preparation electrophoresis from the ribosomes of Serratia odorifera, which were obtained by the method of differential centrifugation. This protein showed specific immune response reactivity with the antiserum of the ribosomes mentioned above. Meanwhile, component P showed apparent protective function for QGY-tumorcharged nude mouse and different ways of giving medicine. It was evident from study results that component P isolated from the ribosomes of Serratia odorifera showed a direct function for tumor growth inhibition and it was the effective component of the ribosomes of Serratia odorifera.
Wang
X
X
Department of Microbiology and Microbial Techique, Fu Dan University, Shanghai 200433.
Liang
W
W
Zhang
W
W
Wang
H
H
Chen
Y
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000517:prevention & control; D012270:Ribosomes / Q000737:chemistry*; D012705:Serratia / Q000737:chemistry*
D000970:Antineoplastic Agents; D001426:Bacterial Proteins