[Inhibitory effect of the combination of DHPAs and hyperbaric oxygen on Japanese B encephalitis virus infection in mice].
OBJECTIVE
To investigate the inhibitory effect of the combination of 2,3-dihydroxypropyl-adenine (DHPAs) and hyperbaric oxygen (HBO) on Japanese B encephalitis virus infection in mice.


METHODS
Mice infected P3-55 and P3-53 virus were used in the experiments. Virus was inoculated intraperitoneally to Kumming strain mice (8.5-9.5 g). Mice were divided into groups and treated in the incubation period of the infection. The duration of treatment was 5 days, and the experiments were terminated at the end of 2 weeks after treatment. The living and the dead were then counted finally.


RESULTS
The intergroup comparison showed marked difference between the control group and combination of DHPAs and hyperbaric oxygen group (P < 0.025 and P < 0.01), but there was no statistical difference between other groups and the control group (P > 0.05).


CONCLUSIONS
The combined treatment of (S) DHPA and/or (RS)-DHPA and HBO has inhibitory effect on Japanese encephalitis virus infection in experimental mice.
Lu
M H
MH
Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiong
H E
HE
Tan
D M
DM
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004664:Encephalitis Virus, Japanese / Q000187:drug effects*; D004672:Encephalitis, Japanese / Q000628:therapy* / Q000821:virology; D006931:Hyperbaric Oxygenation; D051379:Mice; D011897:Random Allocation
D000998:Antiviral Agents; C016391:9-(2,3-dihydroxypropyl)adenine; D000225:Adenine