title: Tumorous deformity of mitral valve leaflet after chordal rupture in a child.
abstract: A case with tumorous deformity of the posterior mitral valve leaflet after spontaneous chordal rupture in a child is described. A partial rupture in the chordae tendineae of the posterior mitral leaflet was found by echocardiography in a 9-year-old Japanese boy. Tumorous bulging was gradually developed in the leaflet and was surgically excised 5 years later. Multiple nodular tumors were found on the atrial surface of the posterior mitral leaflet. Histological examination revealed that the tumorous bulging consisted of myxomatous materials in which collagen fibrils and very fine elastic fibers were distributed loosely and irregularly. Normal-looking endothelial cells covered the luminal surface of the bulging lesion. Vimentin-positive spindle-shaped mesenchymal cells were scattered in the bulge area. The labeling index of proliferating cell nuclear antigen (PCNA) in these cells was 29.3%. These spindle cells were positive for matrix metalloproteinase (MMP)-1 in the entire bulge area. The cells and matrix were positive for MMP-2 and tissue inhibitor of MMP (TIMP)-1 in the basal area of bulging, but were weakly positive or negative at the surface area. Reactivity for TIMP-2 in the cells in the bulge area was obviously weaker than that in the cells at the spongiosa of the anterior mitral leaflet, which was obtained from the patient at the valve replacement operation 9 months after the initial operation. These findings indicated that the tumorous deformity of the mitral valve was formed by the overgrowth of valve tissue under the stimulation of mitral regurgitation in this child, and the imbalance of MMP and TIMP might play an important role in the bulge formation.
authors.affiliation: Division of Surgical Pathology, Nippon Medical School Hospital, Tokyo, Japan. tamura@nms.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugisaki
authors.forename: Shunichi
authors.initials: S
authors.lastname: Ogawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Ryozo
authors.initials: R
authors.lastname: Okada
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002815:Chordae Tendineae; D004452:Echocardiography; D006338:Heart Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008943:Mitral Valve / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009232:Myxoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012422:Rupture, Spontaneous; D016896:Treatment Outcome; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen; D014746:Vimentin