A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13).
We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.
Kojima
Kensuke
K
Department of Internal Medicine II, Graduate School of Medicine and Dentistry, Okayama University, Japan. kkoji@m.ehime-u.ac.jp
Kaneda
Kinuyo
K
Yoshida
Chikamasa
C
Dansako
Hirokata
H
Fujii
Nobuharu
N
Yano
Tomofumi
T
Shinagawa
Katsuji
K
Yasukawa
Masaki
M
Fujita
Shigeru
S
Tanimoto
Mitsune
M
D000123:Acetyltransferases / Q000235:genetics*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D015321:Gene Rearrangement; D051548:Histone Acetyltransferases; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014178:Translocation, Genetic
D002352:Carrier Proteins; D029701:Saccharomyces cerevisiae Proteins; C020723:citrate-binding transport protein; D003561:Cytarabine; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D015255:Idarubicin