title: Induction of humoral and cell-mediated immunity to hepatitis B surface antigen by a novel adjuvant activity of Oka varicella vaccine.
abstract: Oka varicella vaccine induces humoral and cell-mediated immunity to varicella-zoster virus (VZV), even in immunocompromised hosts. This vaccine showed novel adjuvant activity against co-inoculated hepatitis B surface antigen (HBsAg). Either a mixed inoculation of HBsAg with heat-inactivated Oka varicella vaccine at one site or a separate inoculation of HBsAg and live vaccine at different sites induced an antibody response but failed to induce delayed type hypersensitivity (DTH) to HBsAg. In contrast, immunization of HBsAg mixed with live vaccine induced DTH and an enhanced antibody response to HBsAg. The adjuvant activity of Oka varicella vaccine was similar in terms of antibody production to that of alum adjuvant. A T helper cell-dominant immunity to VZV and HBsAg continued for 1 year. Oka varicella vaccine combined with a foreign antigen may serve as a novel polyvalent vaccine for the infectious diseases for which cell-mediated immunity is beneficial.
authors.affiliation: Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Supaporn
authors.initials: S
authors.lastname: Phumiamorn
authors.affiliation: Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kamiyama
authors.affiliation: Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurokawa
authors.affiliation: Department of Virology, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Kimiyasu
authors.initials: K
authors.lastname: Shiraki
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D019433:Chickenpox Vaccine / Q000276:immunology*; D006168:Guinea Pigs; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007114:Immunization; D018417:Th1 Cells / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D019433:Chickenpox Vaccine; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines