title: AMP-activated protein kinase, super metabolic regulator.
abstract: The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
authors.affiliation: St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia. kemp@ariel.unimelb.edu.au
authors.forename: B E
authors.initials: BE
authors.lastname: Kemp
authors.forename: D
authors.initials: D
authors.lastname: Stapleton
authors.forename: D J
authors.initials: DJ
authors.lastname: Campbell
authors.forename: Z-P
authors.initials: ZP
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Murthy
authors.forename: M
authors.initials: M
authors.lastname: Walter
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: J J
authors.initials: JJ
authors.lastname: Adams
authors.forename: F
authors.initials: F
authors.lastname: Katsis
authors.forename: B
authors.initials: B
authors.lastname: van Denderen
authors.forename: I G
authors.initials: IG
authors.lastname: Jennings
authors.forename: T
authors.initials: T
authors.lastname: Iseli
authors.forename: B J
authors.initials: BJ
authors.lastname: Michell
authors.forename: L A
authors.initials: LA
authors.lastname: Witters
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D008055:Lipids; D008954:Models, Biological; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009154:Mutation; D009765:Obesity / Q000235:genetics; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D017434:Protein Structure, Tertiary
chemical_list: D008055:Lipids; D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose