title: Human albumin synthesis is increased by an ultra-endurance trial.
abstract: OBJECTIVE
  The purpose of this study was to determine whether an ultra-endurance event is a strong stimulus to increase albumin synthesis involved in the process of intravascular albumin mass increase associated with transient hypervolemia.
  
  
  METHODS
  The albumin synthetic rate was measured in six young men, 3 d before (C) and on the 1st (R1) and 8th (R8) days of the recovery from an ultra-endurance trial (5 h daily for 4 d). Albumin fractional (FSR) and absolute (ASR) synthetic rate were determined using a primed-constant infusion of [1(-13) C] leucine. Plasma volume (PV) using Evans Blue dye dilution and total body water (TBW) using bioelectrical impedance analysis were measured on C, R1, and R8.
  
  
  RESULTS
  On R1 as compared with C: 1). PV (+23.3 +/- 3.2%; P<or= 0.001) and TBW (+4.2 +/- 0.8%; P<or= 0.01) expanded; 2). FSR and ASR both increased from 5.36 +/- 0.46 to 6.86 +/- 0.62%.24 h (+ 29.0 +/- 7.1%; P<or= 0.01) and from 103 +/- 10 to 153 +/- 19 mg.kg body weight (-1).24 h (-1) (+47.5 +/- 6.8%; P<or= 0.01); and 3). plasma albumin and protein masses increased (P<or= 0.05) from 1.92 +/- 0.08 to 2.22 +/- 0.14 g.kg body weight (-1) (i.e., +15.3 +/- 4.9%) and from 3.15 +/- 0.18 to 3.56 +/- 0.21 g.kg body weight (-1) (+13.3 +/- 3.9%), respectively. By R8, all these parameters had returned to their control levels except for albumin mass (1.73 +/- 0.08 g.kg body weight(-1), which was lower than C ( P<or= 0.05).
  
  
  CONCLUSIONS
  The increase in the albumin synthetic rate the day after an ultra-endurance trial is a major event associated with a greater circulating protein mass. The impact of exercise on albumin synthesis has disappeared 8 d later, as did PV and total protein mass expansion.
authors.affiliation: Laboratoire de Physiologie-Biologie du Sport, Faculté de Médecine, Université d'Auvergne, Clermont-Ferrand, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mischler
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Pierre
authors.initials: P
authors.lastname: Gachon
authors.forename: Vincent
authors.initials: V
authors.lastname: Pialoux
authors.forename: Remi
authors.initials: R
authors.lastname: Mounier
authors.forename: Paulette
authors.initials: P
authors.lastname: Rousset
authors.forename: Jean
authors.initials: J
authors.lastname: Coudert
authors.forename: Nicole
authors.initials: N
authors.lastname: Fellmann
mesh_terms: D000328:Adult; D000418:Albumins / Q000096:biosynthesis*; D001834:Body Water; D001835:Body Weight; D017097:Electric Impedance; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D010953:Plasma Volume
chemical_list: D000418:Albumins