title: Allele frequency determination of publicly available cSNPs in the Korean population.
abstract: OBJECTIVE
  As a first step toward the construction of a single-nucleotide polymorphism (SNP) database of the Korean population, the authors determined the allele frequencies of 406 cSNPs selected from the public database.
  
  
  METHODS
  A pooled DNA sequencing approach was used to determine the allele frequencies of 406 cSNPs selected from 120 genes in 24 individuals.
  
  
  RESULTS
  Of 406 cSNPs, 53% were monomorphic in the Korean samples. Among tested SNPs, 292 SNPs (72%) were uncommon (minor allele < 20%) and 114 SNPs (28%) were common (minor allele > or = 20%) in our population.
  
  
  CONCLUSIONS
  An extensive SNP characterization would be necessary, and the ethnic and population-based differences should be considered in the selection of SNPs for the study of complex diseases with association mapping methods.
authors.affiliation: Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seong-Gene
authors.initials: SG
authors.lastname: Lee
authors.forename: Yongsook
authors.initials: Y
authors.lastname: Yoon
authors.forename: Sunghee
authors.initials: S
authors.lastname: Hong
authors.forename: Jieun
authors.initials: J
authors.lastname: Yoo
authors.forename: Insil
authors.initials: I
authors.lastname: Yang
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
mesh_terms: D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers