Effects of electroconvulsive therapy on regional cerebral blood flow measured by 99mtechnetium HMPAO SPECT.
Decreased cerebral blood flow is documented in depression. In this study, 15 patients were studied with 99mTc-HMPAO SPECT before and after a course of electroconvulsive therapy (ECT). Improvement in frontal and temporal hypoperfusion was seen only in those patients who responded to ECT. Cerebral hypoperfusion may be a state-dependent marker in depressive illness.
Vangu
Mboyo Di Tamba
MD
Division of Nuclear Medicine, Johannesburg Hospital, Private Bag x39, Johannesburg 2000, South Africa. 084mboy@chiron.wits.ac.za
Esser
Jan Daniel
JD
Boyd
Ivan Harry
IH
Berk
Michael
M
D000328:Adult; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime