Suppression of cortical representation through backward conditioning.
Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of cortical reorganization. Pairing ventral tegmental area stimulation with a sound in a backward conditioning paradigm specifically reduced representations of the paired sound in the primary auditory cortex (AI). This temporal sequence-dependent bidirectional cortical plasticity modulated by dopamine release hypothetically serves to prevent the over-representation of frequently occurring stimuli resulting from their random pairing with unrelated rewards.
Bao
Shaowen
S
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA.
Chan
Vincent T
VT
Zhang
Li I
LI
Merzenich
Michael M
MM
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D004594:Electrophysiology; D005260:Female; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013569:Synapses; D013997:Time Factors
D004298:Dopamine