Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report.
This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.
Fridell
Jonathan A
JA
Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.
Jain
Ashok Kumar B
AK
Patel
Kusum
K
Virji
Mohamed
M
Rao
K N
KN
Fung
John J
JJ
Venkataramanan
Raman
R
D019540:Area Under Curve; D004347:Drug Interactions; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D016031:Liver Transplantation / Q000706:statistics & numerical data; D008875:Middle Aged; D010672:Phenytoin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D020123:Sirolimus / Q000097:blood* / Q000627:therapeutic use
D010672:Phenytoin; D020123:Sirolimus