[Involvement of the maxillary sinus in Langerhans cell histiocytosis].
OBJECTIVE
A clinical presentation of Langerhans cell histiocytosis (LCH) in the maxillary sinus of two patients is given. LCH in the maxillary sinus is a rare occurrence. Our aim was to compare the different treatment alternatives available and to suggest a classification as well as a therapeutic regime.


METHODS
Records and clinical data of two patients treated between 1994 and 2001 were retrospectively evaluated. Both patients suffered from LCH in the maxillary sinus and the maxilla regions. Only surgical treatment was used. After resection, a large defect of the maxillary sinus, which did not allowing coverage, was seen in both cases. After reconstructive operations, closure was finally achieved. Both patients underwent follow-ups, whereby one suffered from a relapse after 15 months.


RESULTS
Although one of the patients under investigation showed a recurrence of LCH, we are of the opinion that surgical treatment is very effective in the elimination of this condition. A proposal for a classification of LCH in the oral-maxillo-facial-region is made.


CONCLUSIONS
The evaluation of our clinical study suggests that LCH is a disease that should be treated surgically. Only in very severe cases should the surgical treatment be complimented by either radiotherapy or chemotherapy. In disseminated cases, especially chemotherapy seems to improve the outcome. Surgery offers the possibility of eliminating systemic side effects.
Bartnick
A
A
Mund-Kiefer-Gesichts-Chirurgie, Nordwestdeutsche Kieferklinik, Universitätsklinikum Hamburg-Eppendorf. bartnick@uke.uni-hamburg.de
Friedrich
R E
RE
Röser
K
K
Schmelzle
R
R
D003758:Dental Implantation, Endosseous; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery*; D010254:Paranasal Sinus Diseases / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000601:surgery; D011859:Radiography; D012086:Reoperation; D012189:Retrospective Studies; D013524:Surgical Flaps; D014081:Tooth Extraction