[Simulation of local cerebral hemorrhage in different brain structures of experimental animals].
A standardized experimental model of intracerebral hemorrhagic stroke in small laboratory animals is developed and advanced for chronic neurobiological studies of normal and pathological higher nervous activity as well as disorders developed after acute hemorrhages. A device is advanced which allows a researcher to destroy appropriate brain structures (tissues and local blood vessels) with necessary precision by four-six rotations of curved stereotaxically inserted mandrel-wire knife and, subsequently, to inject autoblood into the area of the lesion. The advanced model is convenient for the reproduction of lesions in different brain regions (for the purpose of experimental knockouts) in neurophysiological, neuropharmacological, and clinical investigations.
Makarenko
A N
AN
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Kositsyn
N S
NS
Pasikova
N V
NV
Svinov
M M
MM
D000818:Animals; D001921:Brain / Q000601:surgery*; D004195:Disease Models, Animal; D020299:Intracranial Hemorrhage, Hypertensive / Q000209:etiology* / Q000473:pathology; D009482:Neurophysiology / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D013238:Stereotaxic Techniques / Q000295:instrumentation; D013525:Surgical Instruments