title: [An experimental study on the implantation of a biomaterial with electro-activity for replacement of hard tissue in bone].
abstract: OBJECTIVE
  To assess the effects of a piezoelectric biological ceramic on osteogenesis.
  
  
  METHODS
  Hydroxyapatite (HA) and piezoelectric biological ceramics (hydroxyapatite and barium titanate, HABT) were implanted in the jawbones of 5 dogs, and for sample collection, the dogs were killed separately at 1 week, 2 weeks, 1 month, 2 months and 3 months after implantation. The samples from a rhesus monkey and a blank control were collected 34 months after implantation. The implanted samples and surrounding tissues were subjected to histological observations using light microscopy (LM) and scanning electronmicroscopy (SEM) were made.
  
  
  RESULTS
  Compared with the control groups, the HABTs promoted osteogenesis significantly. One week after implantation, new bone tissues were found on the surface vertical to the longitudinal direction of HABT; more bone tissues were found after 2 weeks. HABTs induced the bone tissues to arrange orderly. After two years and ten months of implantation, the piezoelectric bioceramic and bone became monolithic, and the structure of bone was normal.
  
  
  CONCLUSIONS
  HABTs could promote osteogenesis.
authors.affiliation: Department of Biomaterials, School of Stomatology, WCUMS, Chengdu 610041, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003758:Dental Implantation, Endosseous; D003776:Dental Porcelain; D004285:Dogs; D017097:Electric Impedance; D020007:Implants, Experimental; D008253:Macaca mulatta; D008297:Male; D008963:Molar / Q000293:injuries; D010012:Osteogenesis
chemical_list: D001672:Biocompatible Materials; D003776:Dental Porcelain