title: [Prion diseases: current views].
abstract: This is a review of the problem. The above diseases represent a peculiar type of fatal neurodegenerative diseases of man and animals provoker of which is prion--a low molecular anucleinic protein resistant to inactivation. Human prior diseases include fatal familial sleeplessness, Kreutzfeldt-Jakob disease, kuru, Gerstmann-Streussler-Sheinker's syndrome, etc. Prion proteins possess a characteristic capacity to change a tertiary conformation resulting in the formation of a pathological form of protein having infectious properties. Pathogenesis, morphological and clinical manifestations as well as principles of diagnosis and treatment of these diseases are discussed.
authors.forename: E A
authors.initials: EA
authors.lastname: Kogan
authors.forename: P V
authors.initials: PV
authors.lastname: Zelenkov
authors.forename: O V
authors.initials: OV
authors.lastname: Uspenskaia
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Epifanov
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D017096:Prion Diseases / Q000145:classification / Q000209:etiology / Q000473:pathology*; D011328:Prions / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D011328:Prions