Antigen-driven clonal T cell expansion in disorders of hematopoiesis.
Patients with myelodysplastic syndrome, aplastic anemia, and LGL leukemia may have overlapping clinical features. This commentary highlights a possible common pathogenetic mechanism of antigen-driven cytotoxic T lymphocytes mediating hematopoietic failure.
Kanchan
Kamath
K
Loughran
Thomas P
TP
D000941:Antigens / Q000276:immunology; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000941:Antigens