title: Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
abstract: Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.
authors.affiliation: Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. steve_colletti@merck.com
authors.forename: Steven L
authors.initials: SL
authors.lastname: Colletti
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Frie
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Dixon
authors.forename: Suresh B
authors.initials: SB
authors.lastname: Singh
authors.forename: Bernard K
authors.initials: BK
authors.lastname: Choi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Scapin
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Fitzgerald
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Nichols
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Keefe
authors.forename: Edward A
authors.initials: EA
authors.lastname: O'Neill
authors.forename: Gene
authors.initials: G
authors.lastname: Porter
authors.forename: Koppara
authors.initials: K
authors.lastname: Samuel
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Schmatz
authors.forename: Cheryl D
authors.initials: CD
authors.lastname: Schwartz
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Shoop
authors.forename: Chris M
authors.initials: CM
authors.lastname: Thompson
authors.forename: James E
authors.initials: JE
authors.lastname: Thompson
authors.forename: Ruixiu
authors.initials: R
authors.lastname: Wang
authors.forename: Andrea
authors.initials: A
authors.lastname: Woods
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Zaller
authors.forename: James B
authors.initials: JB
authors.lastname: Doherty
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D004791:Enzyme Inhibitors; D011724:Pyridazines; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases