title: [Determination of heroin metabolites in biological fluids, tissues and hair of heroin addicts using GC/MS-SIM].
abstract: Using GC/MS-SIM, we examined morphine distribution in human bodies of 2 delayed death cases and analyzed content of morphine and 6-acetylmorphine (MAM) in hair specimens of 7 cases. After hydrolysis and extraction, MOR and 6-MAM were derived with acetic anhydride or BSTFA and then the derivatives were qualitatively and quantitatively analyzed by GC/MS-SIM. The results indicated that urine, bile and liver were the best samples to reveal the heroin-related deaths. Hair analysis has its unique advantage for its long time of abusing monitor, compared to biological fluids.
authors.affiliation: Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063, P. R. China.
authors.forename: P
authors.initials: P
authors.lastname: Xiang
authors.forename: M
authors.initials: M
authors.lastname: Shen
authors.forename: H J
authors.initials: HJ
authors.lastname: Wu
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Huang
mesh_terms: D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D003932:Heroin / Q000378:metabolism*; D006556:Heroin Dependence / Q000378:metabolism; D006801:Humans; D008297:Male; D009020:Morphine / Q000032:analysis*; D009022:Morphine Derivatives / Q000032:analysis*
chemical_list: D009022:Morphine Derivatives; D003932:Heroin; D009020:Morphine; C026979:6-O-monoacetylmorphine