Nodulisporic acids C, C1, and C2: a series of D-ring-opened nodulisporic acids from the fungus Nodulisporium sp.
Nodulisporic acids C (4a), C1 (5a), and C2 (6a), a series of D-ring-opened nodulisporic acids, were isolated from fermentations of a mutant culture of Nodulisporium sp. MF5954. Nodulisporic acid C, the most potent of the three, showed good activity against fleas with an LD90 of 10 micro g/mL. These compounds tend to be unstable in the free acid form and were isolated as stable sodium salts.
Ondeyka
John G
JG
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. john_ondeyka@merck.com
Byrne
Kevin
K
Vesey
Diane
D
Zink
Deborah L
DL
Shoop
Wesley L
WL
Goetz
Michael A
MA
Singh
Sheo B
SB
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D005423:Siphonaptera / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000977:Antiparasitic Agents; D004224:Diterpenes; D007211:Indoles; C474699:nodulisporic acid C; C474702:nodulisporic acid C1; C474700:nodulisporic acid C2