title: Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development.
abstract: Our earlier work implicates transcription factors GATA-4 and GATA-6 in the murine adrenal. We have now studied their expression during mouse and human adrenal development in detail. GATA-4 and GATA-6 mRNAs are readily detectable from embryonic day 15 in mouse and gestational week 19 in human adrenal cortex. In postnatal adrenal, GATA-4 expression is down-regulated, whereas GATA-6 mRNA and protein continue to be abundantly present. In a human adrenocortical cell line NCI-H295R, GATA-6 mRNA is up-regulated by cAMP. This cell line does not express GATA-4. Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation.
authors.affiliation: Children's Hospital, P.O. Box 63, 00014, University of Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Kiiveri
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Westerholm-Ormio
authors.forename: N
authors.initials: N
authors.lastname: Narita
authors.forename: D B
authors.initials: DB
authors.lastname: Wilson
authors.forename: R
authors.initials: R
authors.lastname: Voutilainen
authors.forename: M
authors.initials: M
authors.lastname: Heikinheimo
mesh_terms: D000302:Adrenal Cortex / Q000196:embryology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development; D050991:GATA4 Transcription Factor; D050993:GATA6 Transcription Factor; D006801:Humans; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D050991:GATA4 Transcription Factor; D050993:GATA6 Transcription Factor; C494759:GATA6 protein, human; C494760:Gata6 protein, mouse; D012333:RNA, Messenger; D014157:Transcription Factors; D003994:Bucladesine