[The effects of iron supplementation on auditory brain-stem response with iron deficiency anemia in rats].
OBJECTIVE
To evaluate the therapeutic methods of sensorineural hearing loss with iron deficiency anemia and their effects.


METHODS
Sixty-eight Wistar rats were randomly divided into 3 groups: Group A (iron deficiency group A) 24 rats, group B (iron deficiency group B) 24 rats and group C (control group) 20 rats. Group A and B were fed with iron deficiency diet for 6 weeks. By analyzing ABR and DPOAE, hearing loss was detected in group A and B. Then, group A was given iron supplementation diet and hyperbaric oxygen therapies, and group B was given iron supplementation diet only.


RESULTS
The auditory thresholds and period latencies (PL) of I waves of ABR and DPOAE amplitude in 2 kHz and 3 kHz within group A and B were significantly different before and after treatment (P < 0.05). But the effects of treatment between these two groups had not significant differences (P > 0.05).


CONCLUSIONS
It suggested that good results can be obtained by early iron supplementation in iron deficiency hearing loss cases. Hyperbaric Oxygen therapy may not be necessary.
Zhou
B
B
Department of Otorhinolaryngology, PLA Hospital No. 105, Hefei 230031.
Sun
A
A
Wang
S
S
Ma
Y
Y
Shen
J
J
Wang
Q
Q
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000503:physiopathology; D007501:Iron / Q000627:therapeutic use*; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D007501:Iron