title: Molecular targets in breast cancer: current status and future directions.
abstract: Our increasing understanding of the pathophysiologic mechanisms of breast carcinogenesis has generated detailed information about the potential roles of specific biomolecular markers in this process. Furthermore, in the last few years the process of targeted drug design has become faster and more sophisticated, providing a variety of agents targeted at these molecules. In this review, we describe the most widely recognized molecular targets in breast cancer.
authors.affiliation: Department of Breast Medical Oncology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 424, Houston, Texas 77030, USA. mcristof@notes.mdacc.tmc.edu
authors.forename: M
authors.initials: M
authors.lastname: Cristofanilli
authors.forename: G N
authors.initials: GN
authors.lastname: Hortobagyi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D015195:Drug Design; D005260:Female; D005544:Forecasting; D005819:Genetic Markers; D006801:Humans; D009389:Neovascularization, Pathologic
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D005819:Genetic Markers