Salycylate--induced pancreatic injury in the cat: a preliminary study.
The effect of intravenous aspirin on the exocrine pancreatic secretion was investigated in a feline isolated pancreaticoduodenal preparation. The study group received a 500 mg/kg bolus dose of aspirin intravenously. Duodenal washouts were collected for six hours. The serum and perfusate aspirin content increased significantly after aspirin administration (p = 0.01). However, the pH, bicarbonate, sodium, potassium and calcium content in the duodenal outflow did not show significant changes between 0 and 6 hours. A significant difference in the perfusate calcium content was present between ASA treated and control cats starting at the end of the first hour of the experiment (p=0.005). Histopathological examination of the pancreas revealed marked erythrocyte extravasation in the ASA treated animals. It is suggested that the ASA- related increase in the calcium secretion of the pancreas should be regarded as an indication of aspirin induced pancreatic damage.
Mentes
Ali
A
Department of Surgery, Aegean University Faculty of Medicine, Bornova, 35100 Yzmir, Turkey.
Batur
Y
Y
Bayol
U
U
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers; D002118:Calcium / Q000378:metabolism; D002415:Cats; D004195:Disease Models, Animal; D010195:Pancreatitis / Q000139:chemically induced* / Q000473:pathology / Q000662:veterinary
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D001241:Aspirin; D002118:Calcium