Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson's disease.
Through electrodes implanted for deep brain stimulation in three patients (5 sides) with Parkinson's disease, we recorded the electrical activity from the human basal ganglia before, during and after voluntary contralateral finger movements, before and after L-DOPA. We analysed the movement-related spectral changes in the electroencephalographic signal from the subthalamic nucleus (STN) and from the internal globus pallidus (GPi). Before, during and after voluntary movements, signals arising from the human basal ganglia contained two main frequencies: a high beta (around 26 Hz), and a low beta (around 18 Hz). The high beta (around 26 Hz) power decreased in the STN and GPi, whereas the low beta (around 18 Hz) power decrease was consistently found only in the GPi. Both frequencies changed their power with a specific temporal modulation related to the different movement phases. L-DOPA specifically and selectively influenced the spectral power changes in these two signal bands.
Priori
A
A
Department of Neurological Sciences, IRCCS Ospedale Maggiore, Policlinico, University of Milan, Padiglione Ponti, Via F. Sforza 35, 20122 Milan, Italy.
Foffani
G
G
Pesenti
A
A
Bianchi
A
A
Chiesa
V
V
Baselli
G
G
Caputo
E
E
Tamma
F
F
Rampini
P
P
Egidi
M
M
Locatelli
M
M
Barbieri
S
S
Scarlato
G
G
D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001479:Basal Ganglia / Q000187:drug effects; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D005385:Fingers; D005917:Globus Pallidus / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D009068:Movement; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000187:drug effects* / Q000503:physiopathology
D000978:Antiparkinson Agents; D007980:Levodopa