title: Peripheral benzodiazepine receptors: on mice and human brain imaging.
abstract: There are numerous methods designed to monitor brain neuropathologies resulting from a wide arsenal of insults. Regardless of the cause of neuronal death, reactive glial cells always appear at and around the site of degeneration. These cells are distinguished by the exceptional abundance of peripheral benzodiazepine receptors, particularly compared with surrounding neurons. Measuring the binding of specific ligands to these peripheral benzodiazepine receptors offers a unique indirect marker for reliable damage assessment in the CNS and a faithful indicator for the accompanying cognitive deficits.
authors.affiliation: Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona, Israel. baw@iibr.gov.il
authors.forename: Ben Avi
authors.initials: BA
authors.lastname: Weissman
authors.forename: Lily
authors.initials: L
authors.lastname: Raveh
mesh_terms: D000818:Animals; D001345:Autoradiography; D001570:Benzodiazepinones / Q000493:pharmacokinetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D002250:Carbon Radioisotopes; D005911:Gliosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics; D008024:Ligands; D051379:Mice; D011237:Predictive Value of Tests; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000378:metabolism*; D013379:Substrate Specificity; D014055:Tomography, Emission-Computed; D014316:Tritium
chemical_list: D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D007546:Isoquinolines; D008024:Ligands; D011963:Receptors, GABA-A; D014316:Tritium; C028513:4'-chlorodiazepam; C037850:PK 11195