[Sedative and anticonvulsant effect of jujuboside A]
OBJECTIVE: To study the sedative effects of Jujuboside A (JuA) on the Central Nervous System of mice. METHODS: Using a novel jiggle-cage test, we compared the sedative effect of JuA with that of Diazepam (DZP) both with a single and cumulative dose of JuA. We also assessed the anticonvulsant effect of JuA on pentylenetetrazol (PTZ)-induced seizures in mice. RESULTS: JuA significantly decreased total activity intensity and increased the quiet state time of mice. The sedative effects of JuA were more stable and more lasting than that of DZP. However, JuA failed to resist and delay the induced seizure activity in mice. CONCLUSION: Though JuA has sedative effects on mice CNS, it has no anticonvulsant effect on PTZ-induced seizures.
Feng
Zhou-Yan
ZY
College of Life Sciences, Zhejiang University, Hangzhou 310027, China.
Guo
Dian-Wu
DW
Su
Song
S
Zhao
Hui
H
Zheng
Xiao-Xiang
XX