title: Lobular capillary hemangioma of the oral mucosa: clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements.
abstract: Clinical and histopathological features were investigated in 43 cases of oral lobular capillary hemangiomas (LCH) with a special reference to characteristics of the vascular elements. The lesions affected females more than males by a ratio of 1:1.5. Average age of the patients was 52.7 years. The lesions involved the gingiva (n = 15), the tongue (n = 13), the labial mucosa (n = 10) and other sites. The lesions appeared usually as a pedunculated mass with ulceration; size of the lesions was up to 15 mm. Histologically, a lobular area and an ulcerative area were distinguished. The density of vessels was about 1045/mm2 and 160/mm2 in the lobular and ulcerative areas, respectively. The average diameter of the vascular lumen was 9.1 5.6 mm (range: 2.8-42.0 mm) and 18.8 20.9 mm (range: 5.6-139.7 mm) in the lobular and ulcerative areas, respectively. In the lobular area, most of the vessels had an inner layer of endothelial cells showing positive reaction for von Willebrand factor (vWF) and CD34, as well as an outer layer of mesenchymal cells showing positive reaction for alpha-smooth muscle actin (ASMA). However, in the ulcerative area, there was a variety of types of vessels consisting of various proportions of both endothelial and ASMA-positive perivascular mesenchymal cells. These results indicate that most of the vascular elements in the lobular area resemble more pericapillary microvascular segments than they do capillaries. Thus, the authors propose the term 'lobular pericapillary hemangioma' to represent this type of lesion.
authors.affiliation: Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu, Japan. toida@cc.gifu-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Toida
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Watanabe
authors.forename: Keizo
authors.initials: K
authors.lastname: Kato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Makita
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujitsuka
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kato
authors.forename: Ken
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shibata
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Shimokawa
mesh_terms: D000199:Actins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D002648:Child; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005260:Female; D017789:Granuloma, Pyogenic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism / Q000473:pathology*; D009061:Mouth Mucosa / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014841:von Willebrand Factor