A case of pulmonary adenocarcinoma associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor.
A 62-year-old male patient was admitted, because a chest X-ray examination revealed an abnormal shadow (4 cm in diameter) in the left upper lobe. A transbronchial lung biopsy showed the features of adenocarcinoma. Chest and abdominal computed tomography (CT) scan showed the features of lymphangitis carcinomatosa, and bilateral metastatic adrenal tumors. After effective chemotherapy, he complained of arthralgia and a bone scintigram showed abnormal uptakes in his bilateral shoulder, knee and wrist. He was diagnosed with pulmonary hypertrophic osteoarthropathy (PHOA). The serum level of vascular endothelial growth factor (VEGF) was elevated to 424 pg/ml, while serum growth hormone (GH) and GH-releasing hormone were normal. Immunohistochemical analysis showed positive features of VEGF in the pulmonary tumor cells. He died of cachexia on May 2nd, 2001, more than 2 years after the diagnosis of pulmonary adenocarcinoma at stage IV.
Abe
Yoshiyuki
Y
Department of Respiratory Disease, National Kanagawa Hospital, Ochiai 666-1, Kanagawa, 257-8585, Japan.
Kurita
Satoshi
S
Ohkubo
Yasuyuki
Y
Usui
Hiroshi
H
Hashizume
Toshinori
T
Nakamura
Masato
M
Ueyama
Yoshito
Y
Fujino
Tadahiko
T
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D009077:Mucins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors