Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma.
We used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open angle glaucoma (POAG), and 15 normal controls. The most statistically significant (P=0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-response. A sensitivity of 93% was achieved, with 60% specificity at minimum error rate. This is presumed to reflect reduced activity in the S-cone and magnocellular visual pathways, and may provide an effective method for research and monitoring change in early glaucoma.
Aldebasi
Yousef H
YH
Department of Optometry, King Saud University, Riyadh, Saudi Arabia.
Drasdo
Neville
N
Morgan
James E
JE
North
Rachel V
RV
D000368:Aged; D016022:Case-Control Studies; D005074:Evoked Potentials, Visual; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways