Oral cadmium exposure throughout puberty does not inhibit secretion of prolactin, GH and ACTH through dopamine metabolism changes in male rat.
This work analyzed possible dopamine-mediated cadmium effects on plasma prolactin, GH and ACTH levels and if these changes were related to metal accumulation. Male rats were treated from day 30 to 60 of life with 50 mg/L of CdCl2 in the drinking water. Cadmium exposure decreased the dopamine (DA) metabolism (DOPAC/DA ratio) in all brain areas studied, and plasma levels of prolactin, GH and ACTH were diminished. The cadmium concentration did not increase nor in hypothalamus nor in the pituitary after the metal exposure. These results suggest that cadmium inhibits the secretion of these pituitary hormones and this inhibitory effect is not mediated by dopamine or the degree of metal accumulation.
Lafuente
Anunciación
A
Laboratorio de Toxicología, Facultad de Ciencias, Universidad de Vigo, Orense, Spain. lafuente@uvigo.es
González-Carracedo
Aníbal
A
Márquez
Nuria
N
Pazo
David
D
Esquifino
Ana I
AI
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000284:Administration, Oral; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D004298:Dopamine / Q000737:chemistry / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D011388:Prolactin / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012741:Sexual Maturation / Q000502:physiology*
D002104:Cadmium; D015102:3,4-Dihydroxyphenylacetic Acid; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D004298:Dopamine