title: Recombinant interferon alfa 2a in hepatic hemangiomatosis with congestive heart failure: a case report.
abstract: A 45-day-old patient was admitted with dyspnea, hepatomegaly, tachycardia, holosystolic murmur in the precordial region, and continuous murmur at the right hypochondrium. Four cutaneous angiomas were noted. Instrumental examinations revealed congestive heart failure and multiple focal lesions in the liver with typical features of hemangiomas. The therapy with subcutaneous interferon-alfa-2a (IFN-alpha) was administered for 12 months with progressive regression of cutaneous hemangiomas, liver lesions, and cardiological alterations. IFN-alpha therapy was effective without any significant adverse effects.
authors.affiliation: Department of Pediatrics-Oncology, University of Rome La Sapienza, Rome, Italy. amaliasc@tiscalinet.it
authors.forename: A
authors.initials: A
authors.lastname: Schiavetti
authors.forename: M D
authors.initials: MD
authors.lastname: De Pasquale
authors.forename: S
authors.initials: S
authors.lastname: Di Salvo
authors.forename: F
authors.initials: F
authors.lastname: Ventriglia
authors.forename: A
authors.initials: A
authors.lastname: Clerico
mesh_terms: D000008:Abdominal Neoplasms / Q000151:congenital / Q000188:drug therapy; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D004071:Digitalis Glycosides / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004417:Dyspnea / Q000209:etiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000151:congenital / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology*; D006344:Heart Septal Defects, Atrial / Q000150:complications; D006365:Heel; D006391:Hemangioma / Q000151:congenital / Q000188:drug therapy* / Q000503:physiopathology; D018324:Hemangioma, Capillary / Q000151:congenital / Q000188:drug therapy; D006392:Hemangioma, Cavernous / Q000151:congenital / Q000188:drug therapy; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007223:Infant; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007717:Knee; D008113:Liver Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000503:physiopathology; D009378:Neoplasms, Multiple Primary / Q000151:congenital / Q000188:drug therapy; D011994:Recombinant Proteins; D012074:Remission Induction
chemical_list: D020533:Angiogenesis Inhibitors; D004071:Digitalis Glycosides; D004232:Diuretics; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005665:Furosemide