title: A case of diffuse leptomeningeal oligodendrogliomatosis associated with HHV-6 variant A.
abstract: We describe a rare case of diffuse leptomeningeal oligodendrogliomatosis associated with the human herpes virus 6 variant A (HHV-6 A). A 2-year-old boy presented with progressive neurological symptoms and hydrocephalus. The patient had a VP shunt placement but did not fully recover. HHV-6 A was detected in both CSF and serum by nested PCR. His symptoms improved repeatedly, but temporarily, on antiviral treatment. An open brain biopsy, ten months after presentation, revealed leptomeningeal tumour as well as the presence of viral DNA in the tumour tissue. The role of HHV-6 A could be that of a reactivated opportunist. However, this case also raises the question whether this neurotropic virus, with malignant transforming properties in vitro, may have a role in pathogenesis in some cases of brain malignancy.
authors.affiliation: Department of Neuropediatrics, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden. tommy.stodberg@ks.se
authors.forename: T
authors.initials: T
authors.lastname: Stödberg
authors.forename: Y
authors.initials: Y
authors.lastname: Deniz
authors.forename: N
authors.initials: N
authors.lastname: Esteitie
authors.forename: B
authors.initials: B
authors.lastname: Jacobsson
authors.forename: M
authors.initials: M
authors.lastname: Mousavi-Jazi
authors.forename: H
authors.initials: H
authors.lastname: Dahl
authors.forename: B
authors.initials: B
authors.lastname: Zweygberg Wirgart
authors.forename: L
authors.initials: L
authors.lastname: Grillner
authors.forename: A
authors.initials: A
authors.lastname: Linde
mesh_terms: D002675:Child, Preschool; D015654:Herpesvirus 6, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000821:virology*; D018302:Neoplasms, Neuroepithelial / Q000209:etiology* / Q000473:pathology / Q000821:virology*; D009837:Oligodendroglioma / Q000209:etiology* / Q000473:pathology / Q000821:virology*