Long-term virological outcome in patients infected with multi-nucleoside analogue-resistant HIV-1.
The emergence of HIV strains that are resistant to antiretroviral drugs is a major cause of treatment failure. Two sets of mutations: the Q151 M complex and the 69 insert, cause resistance to multiple nucleoside analogues. We report the response to treatment in 12 patients with multiple NRTI-resistant HIV-1 strains. Seven of 12 patients (58%) were able to maintain a viral load below 200 copies/ml at week 48. The patients most likely to obtain therapeutic success were those having no or low-level resistance to non-nucleoside reverse transcriptase inhibitors and/or protease inhibitors. New and more effective drugs are needed for patients with HIV-1 that is resistant to more than one of the current three classes of HIV drugs.
Clevenbergh
Philippe
P
Outpatients clinic, Paris, France. clevenberghph@hotmail.com
Kirstetter
Myriam
M
Liotier
Jean-Yves
JY
Dupon
Michel
M
Philibert
Patrick
P
Jacomet
Christine
C
Cua
Eric
E
Montagne
Nathalie
N
Schmit
Jean Claude
JC
Dellamonica
Pierre
P
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral; D004359:Drug Therapy, Combination; D015497:HIV-1; D006801:Humans; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*; D019562:Viral Load
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors