Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers.
Expression of retinoic acid receptor beta (RAR beta) and telomerase catalytic subunit (human telomerase reverse transcriptase [hTERT]) was analyzed in 285 bronchial biopsy specimens from 53 heavy cigarette smokers and four former smokers by using in situ hybridization. Of the 191 biopsy specimens that were positive for RAR beta, 69% expressed hTERT, whereas only 54% of the 94 RAR beta negative biopsy specimens expressed hTERT (P =.014). Because hTERT expression in bronchial tissue has been previously associated with increased risk of lung cancer, the association between RAR beta and hTERT expression suggests that RAR beta expression may be an indicator of increased risk of lung cancer in heavy smokers.
Soria
Jean-Charles
JC
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, USA.
Xu
Xiaochun
X
Liu
Diane D
DD
Lee
J Jack
JJ
Kurie
Jonathan
J
Morice
Rodolfo C
RC
Khuri
Fadlo
F
Mao
Li
L
Hong
Waun K
WK
Lotan
Reuben
R
D000328:Adult; D000368:Aged; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D001980:Bronchi / Q000378:metabolism*; D020134:Catalytic Domain; D004268:DNA-Binding Proteins; D005260:Female; D017313:Fenretinide / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000201:enzymology / Q000378:metabolism*; D012307:Risk Factors; D012907:Smoking / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism*; D013997:Time Factors; D015854:Up-Regulation
D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D018168:Receptors, Retinoic Acid; C082925:retinoic acid receptor beta; D017313:Fenretinide; D019098:Telomerase