Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture.
Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential for transmission and establishment of infection. The B. burgdorferi beta(3) integrin ligand P66 is expressed by the bacteria in mammals, laboratory culture, and engorged but not unfed ticks. No in vitro culture conditions in which P66 expression reflected that in the unfed tick were found, suggesting that there are aspects of B. burgdorferi-tick interaction that remain unexplored.
Cugini
Carla
C
Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, Boston, Massachusetts, USA.
Medrano
Melisa
M
Schwan
Tom G
TG
Coburn
Jenifer
J
D000818:Animals; D001426:Bacterial Proteins; D025065:Borrelia burgdorferi / Q000254:growth & development* / Q000378:metabolism; D003470:Culture Media; D005247:Feeding Behavior; D015964:Gene Expression Regulation, Bacterial; D006863:Hydrogen-Ion Concentration; D039661:Integrin beta3 / Q000378:metabolism; D018884:Ixodes / Q000382:microbiology* / Q000502:physiology; D008024:Ligands; D051379:Mice; D018272:Porins / Q000235:genetics / Q000378:metabolism*; D013696:Temperature
D001426:Bacterial Proteins; D003470:Culture Media; D039661:Integrin beta3; D008024:Ligands; C107893:Oms66 protein, Borrelia; D018272:Porins