Intra-erythrocyte deposition of growth hormone in rheumatic diseases.
Standard radioimmunoassay was employed to quantify matched basal intra-erythrocyte growth hormone (GH) and serum GH levels from patients with osteoarthritis, diffuse idiopathic skeletal hyperostosis (DISH), gout, and Sjögren's syndrome and in a group of normal volunteers (control group). Basal intra-erythrocyte GH concentration was significantly higher ( P<0.05) than serum GH concentration in blood samples from patients with osteoarthritis and DISH but not from those with gout or Sjögren's syndrome. Regression analysis determined that basal serum GH levels did not correlate with age. While intra-erythrocyte GH levels exceeded serum GH levels in osteoarthritis and DISH, intra-erythrocyte GH was not a strong predictor of serum GH levels in osteoarthritis, DISH, or in the control group.
Denko
Charles W
CW
Department of Medicine, Case Western Reserve University School of Medicine, Division of Rheumatic Diseases, Foley Building, Room 207, 2061 Cornell Road, Cleveland, OH 44106-5076, USA.
Boja
Betty
B
Malemud
Charles J
CJ
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006073:Gout / Q000097:blood / Q000503:physiopathology; D019382:Human Growth Hormone / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000503:physiopathology; D011336:Probability; D011863:Radioimmunoassay; D012016:Reference Values; D012044:Regression Analysis; D012216:Rheumatic Diseases / Q000097:blood* / Q000503:physiopathology; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000097:blood / Q000503:physiopathology
D015415:Biomarkers; D019382:Human Growth Hormone