[Antibacterial activities of seven commonly used antibiotics to 106 isolated strains of porphyromonas gingivalis in vitro].
OBJECTIVE
Porphyromonas gingivalis (Pg) is one of the main putative pathogens of periodontal disease, especially of adult periodontitis. This in vitro study was aimed at observing the inhibitory activities of 7 commonly used antimicrobical drugs on 106 stains of Pg which isolated from subgingival plaques of sites with adult periodontits.


METHODS
Kirby-Bauer paper disk method was used in this study.


RESULTS
Pg was highly susceptible to Clindamycin, Sulfamzthoxazole timethoprin, Tetracycline and Cefazolin, the susceptibility rates were 93.4%, 78.3%, 60.4% and 56.6% respectively.


CONCLUSIONS
Majority of the strains of Pg was moderately susceptible to cefalexin and acetylspiramycin, while no strains of Pg was susceptible to Penicillin G. The concentrations of Pg solutions (10(5) CFU/ml, 10(6) CFU/ml and 10(8) CFU/ml) had not influence on the results. This data is helpful for clinically antibiotic selection of periodontal treatment.
Tang
M
M
Department of Stomatology, First Hospital, Chongqing University of Medical Sciences.
Zhang
J
J
Xiao
X
X
Zhu
Z
Z
Liu
Y
Y
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005881:Gingiva / Q000382:microbiology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010518:Periodontitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents