Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses.
Serine palmitoyltransferase is the first and rate-limiting enzyme of sphingolipid synthesis. As such, it is a central control point in the synthesis of bioactivate sphingolipids, and it plays an important role in mediating cellular stress responses. In this review, its role in mediating these responses is discussed within the context of de novo ceramide synthesis. Furthermore, a discussion is provided of its regulation as discerned from both yeast and mammalian studies.
Perry
David K
DK
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Hollings Cancer Center, 86 Jonathon Lucas St., P.O. Box 250955, Charleston, SC 29403, USA. perryd@musc.edu
D000217:Acyltransferases / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002518:Ceramides / Q000096:biosynthesis*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008956:Models, Chemical; D009154:Mutation; D018384:Oxidative Stress; D012440:Saccharomyces; D051102:Serine C-Palmitoyltransferase
D002518:Ceramides; D000217:Acyltransferases; C495089:SPTLC2 protein, human; D051102:Serine C-Palmitoyltransferase