Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole.
OBJECTIVE
To evaluate the fungitoxic activity of the essential oil of Agastache rugosa alone and to determine its combination effect with ketoconazole against Blastoschizomyces capitatus.


RESULTS
The antifungal activities of the essential oil of A. rugosa and its main constituent estragole were investigated using the broth microdilution, disk diffusion methods and checkerboard microtitre assay. Both estragole and the essential oil exhibited strong activities against the tested fungi and showed synergism with ketoconazole against B. capitatus.


CONCLUSIONS
Both estragole and the essential oil of A. rugosa have significant growth-inhibiting activities against B. capitatus showing strong synergistic effect with ketoconazole.


CONCLUSIONS
The essential oil of A. rugosa, combined with ketoconazole, may be particularly useful against B. capitatus, a rare pathogenic fungus documented to cause severe and fatal mycoses in immunocompromised patients.
Shin
S
S
College of Pharmacy, Duksung Women's University, Ssangmoondong 419, Dobongku, Seoul, Korea. swshin@duksung.ac.kr
Kang
C-A
CA
D031327:Agastache / Q000737:chemistry*; D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000517:prevention & control; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000935:Antifungal Agents; D009822:Oils, Volatile; C007633:estragole; D007654:Ketoconazole