title: [Effects of TAK-147, a novel acetylcholinesterase inhibitor, on spatial memory deficit as evaluated by Morris water maze of rats]
abstract: OBJECTIVE: To evalute the effects of TAK-147, a novel acetylcholinesterase inhibitor on rat spatial memory deficit using the Morris water maze. METHODS: Morris water maze was used to measure spatial memory in rats, and open field test was used to analysis locomotor activity. RESULTS: Scopolamine (0.4mg/kg,IP) significantly increased the latency period in memory acquisition. Intraperitoneal TAK-147 injection ameliorated scopolamine-induced deficit in a dose-related manner. A significant effect was obtained at doses of 0.3 and 1.0 mg/kg. Both TAK-147 (0.3 and 1.0 mg/kg) and tacrine (3 and 5 mg/kg) significantly reversed scopolamine (1.5 mg/kg) increased latency in memory retrieval. However, TAK-147 had a more potent effect than tacrine. In the locomotor test, TAK-147 created no appreciable change, compared with scopolamine or saline. CONCLUSION: A novel acetycholinesterase inhibitor, TAK-147 ameliorates the scopolamine induced impaired spatial memory in rats.
authors.affiliation: College of Medical Sciences, Zhejiang University, Hangzhou 310031, China.
authors.forename: A-Jing
authors.initials: AJ
authors.lastname: Xu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Ren
authors.initials: R
authors.lastname: Li
authors.forename: Chao-Yang
authors.initials: CY
authors.lastname: Zhu
authors.forename: Er-Qing
authors.initials: EQ
authors.lastname: Wei