I do it my way: Regulation of ammonium uptake and ammonium assimilation in Corynebacterium glutamicum.
In order to utilize different nitrogen sources and to survive situations of nitrogen limitation, microorganisms have developed several mechanisms to adapt their metabolism to changes in the nitrogen supply. In this communication, recent advances in our knowledge of ammonium uptake, its assimilation, and connected regulatory systems in Corynebacterium glutamicum are discussed with respect to the situation in the bacterial model organisms Escherichia coli and Bacillus subtilis. The regulatory network of nitrogen control in C. glutamicum differs substantially from that in these bacteria, for example, by the presence of AmtR, the unique "master regulator" of nitrogen control, the absence of a NtrB/NtrC two-component signal transduction system, and a different sensing mechanism in C. glutamicum.
Burkovski
Andreas
A
Institut für Biochemie der Universität zu Köln, Zülpicher-Strasse 47, 50674, Köln, Germany. a.burkovski@uni-koeln.de
D001412:Bacillus subtilis / Q000378:metabolism; D001482:Base Composition; D002352:Carrier Proteins / Q000378:metabolism; D003352:Corynebacterium / Q000145:classification / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009171:Mycolic Acids / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*; D015398:Signal Transduction
D002352:Carrier Proteins; D009171:Mycolic Acids; D000644:Quaternary Ammonium Compounds; D009584:Nitrogen