title: An efficient and practical N-methylation of amino acid derivatives.
abstract: [reaction: see text] An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.
authors.affiliation: Process Research and Development, Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA. mahavir.prashad@pharma.novartis.com
authors.forename: Mahavir
authors.initials: M
authors.lastname: Prashad
authors.forename: Denis
authors.initials: D
authors.lastname: Har
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.forename: Hong-Yong
authors.initials: HY
authors.lastname: Kim
authors.forename: Oljan
authors.initials: O
authors.lastname: Repic
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Blacklock
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D008745:Methylation; D012972:Sodium Hydroxide / Q000737:chemistry; D013463:Sulfuric Acid Esters / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D013463:Sulfuric Acid Esters; D014867:Water; D012972:Sodium Hydroxide; C007482:dimethyl sulfate