[Histological and molecular-biological markers of malignancy in different variants of thyroid papillary carcinoma].
Material for this study from 61 patients (thyroid papillary carcinoma) is shown to represent a heterogenic group of tumors differing from each other morphologically, molecular-biologically and histogenetically. The most malignant were long-cell and B-cell variants and the least malignant--a follicular variant. 81% of the tumors had neuro-endocrine differentiation and their malignant potential was higher compared to tumors without this differentiation.
Sviridova
T E
TE
I. M. Sechenov Moscow Medical Academy, 119881, Moscow.
Kogan
E A
EA
Pal'tsev
M A
MA
Seredin
V P
VP
D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000276:immunology; D009361:Neoplasm Invasiveness; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000276:immunology; D013964:Thyroid Neoplasms / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018396:Mucin-1; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2