[Transcriptional activator PlcR regulate the expression of multiple genes in Bacillus cereus].
Food-poisoning and some diseases of human can be caused by potential pathogenic factors including phospholipases of c-type, hemolysins, enterotoxins, emetic toxin and others from Bacillus cereus which is an opportunistic pathegon. Generally, the expression of pathogenic genes is completed by a co-regulation in many bacteria. The isolation of a mutant, displaying significant reducing expression of lecithinase and general proteolytic activities, from a transposon-induced bank of B. cereus type strain ATCC14579T were described. Sequencing data revealed that a gene with high homology to transcriptional activator (plcR) of B. thuringiensis was inactivated by insertion in this mutant. The results suggest that plcR regulates the expression of multiple genes in B. cereus.
Wang
L
L
Department of Microbial Science and Technology, Huazhong Agricultural University, Key Laboratory of Agro-Microbiology, Ministry of Agriculture, Wuhan, 430070, China.
Chen
Y
Y
Mahillion
J
J
Yu
Z
Z
D000595:Amino Acid Sequence; D001409:Bacillus cereus / Q000235:genetics*; D001413:Bacillus thuringiensis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D020868:Gene Silencing; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D010740:Phospholipases / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C099480:PlcR protein, Bacillus; D015534:Trans-Activators; D010740:Phospholipases