title: Dynamic contrast enhanced magnetic resonance imaging aids the surgical management of invasive lobular breast cancer.
abstract: OBJECTIVE
  Infiltrating Lobular Carcinoma (ILC) accounts for 5-10% of all breast cancers and is associated with subtle clinical and mammographic changes. It is also frequently multifocal and traditional diagnostic methods are unable to reliably detect this preoperatively. The aim of the study was to evaluate the efficacy of current imaging modalities compared with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the evaluation of ILC.
  
  
  METHODS
  Data from women with ILC treated between 1996 and 2000 who had undergone preoperative triple assessment and DCE-MRI was analysed. The diagnostic accuracy and the detection of multifocal disease for each modality was assessed and any changes in clinical management following DCE-MRI were recorded.
  
  
  RESULTS
  Twenty-one women (mean age 57, range 43-72 years) were recruited. The sensitivity of X-ray mammography, ultrasound, clinical assessment, fine needle aspiration cytology or core biopsy and DCE-MRI was 90.5, 87.5, 76.2, 85.7 and 95.2% respectively. DCE-MRI identified all the patients with subsequently histologically proven multifocal disease (n=11) with PPV and NPV of 100 and 95.2% respectively. X-ray mammography and ultrasound combined identified only 27% (n=3/11) with PPV and NPV of 100 and 55.6% respectively. Management was changed in 24% (5/21) of the cases following DCE-MRI.
  
  
  CONCLUSIONS
  DCE-MRI has a higher sensitivity than other imaging modalities and is able to accurately delineate multifocal disease not evident on conventional imaging. DCE-MRI should therefore be used for accurate staging prior to surgery for invasive lobular breast cancer.
authors.affiliation: Academic Surgical Unit, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kneeshaw
authors.forename: L W
authors.initials: LW
authors.lastname: Turnbull
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: P J
authors.initials: PJ
authors.lastname: Drew
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D003287:Contrast Media; D019468:Disease Management; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D016217:Ultrasonography, Mammary; D006113:United Kingdom; D016387:Women's Health
chemical_list: D003287:Contrast Media