title: Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
abstract: BACKGROUND
  A critical point during craniotomy is opening of dura, where a high intracranial pressure (ICP) results in swelling of cerebral tissue. Controlled studies concerning ICP, degree of dural tension, and degree of cerebral swelling are therefore warranted.
  
  
  METHODS
  In an open-label study, 117 patients with supratentorial cerebral tumors were randomized to propofol-fentanyl (group 1), isoflurane-fentanyl (group 2), or sevoflurane-fentanyl anesthesia (group 3). Normo- to moderate hypocapnia was applied, with a target level of arterial carbon dioxid tension of 30-40 mmHg. Mean arterial blood pressure was stabilized with intravenous ephedrine (2.5-5 mg) if necessary. Subdural ICP, mean arterial blood pressure, cerebral perfusion pressure (CPP), arteriovenous oxygen difference (AVDo2), internal jugular vein oxygen saturation were monitored before and after a 10-min period of hyperventilation, and the carbon dioxide reactivity was calculated. Furthermore, the tension of dura before and during hyperventilation and the degree of cerebral swelling during hyperventilation and after opening of the dura were estimated by the neurosurgeon.
  
  
  RESULTS
  No differences were found between groups with regard to demographics, neuroradiologic examination, positioning of the head, and time to ICP measurement. Before and during hyperventilation, ICP was significantly lower and mean arterial blood pressure and CPP significantly higher in group 1 compared with groups 2 and 3 (P < 0.05). The tension of dura before and during hyperventilation was significantly lower in group 1 compared with group2 (P < 0.05), but not significantly different from group 3. In group 1, cerebral swelling after opening of dura was significantly lower compared with groups 2 and 3 (P < 0.05). Furthermore, AVDo was significantly higher and jugular vein oxygen saturation and carbon dioxide reactivity were significantly lower in group 1 compared with groups 2 and 3 (P < 0.05). No significant differences with regard to ICP, CPP, AVDo, carbon dioxide reactivity, and jugular vein oxygen saturation were found between patients anesthetized with isoflurane and sevoflurane.
  
  
  CONCLUSIONS
  The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane. These findings were associated with less tendency for cerebral swelling after opening of dura in the propofol group. The carbon dioxide reactivity in patients anesthetized with isoflurane and sevoflurane was significantly higher than in the propofol group. The differences in subdural ICP between the groups are presumed to be caused by differences in the degree of vasoconstriction elicited by the anesthetic agents, but autoregulatory mechanisms caused by differences in CPP cannot be excluded.
authors.affiliation: Department of Anesthesia and Neurosurgery, Aarhus University Hospital, Denmark.
authors.forename: Kurt D
authors.initials: KD
authors.lastname: Petersen
authors.forename: Uffe
authors.initials: U
authors.lastname: Landsfeldt
authors.forename: Georg Emil
authors.initials: GE
authors.lastname: Cold
authors.forename: Carsten B
authors.initials: CB
authors.lastname: Petersen
authors.forename: Søren
authors.initials: S
authors.lastname: Mau
authors.forename: John
authors.initials: J
authors.lastname: Hauerberg
authors.forename: Peter
authors.initials: P
authors.lastname: Holst
authors.forename: Karsten Skovgaard
authors.initials: KS
authors.lastname: Olsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001929:Brain Edema / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003399:Craniotomy; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D007427:Intracranial Pressure / Q000502:physiology*; D007530:Isoflurane; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015742:Propofol; D000077149:Sevoflurane; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000503:physiopathology*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D007530:Isoflurane; D010100:Oxygen; D005283:Fentanyl; D015742:Propofol