[Expression of cell cycle associated proteins cyclin D1 and P16 in endometrial carcinoma and the correlation between their expression status].
OBJECTIVE
To study the expression of cell cycle associated proteins Cyclin D1, P16 in endometrial carcinoma and their correlation to clinical parameters, and to assess the correlation between their expression status.


METHODS
Immunohistochemical method was used to detect Cyclin D1 and P16 expressions in 64 cases of endometrial carcinoma.


RESULTS
The positive rate of Cyclin D1 was 54.68%. The Cyclin D1 expression was significantly associated with FIGO stage (P < 0.05). The positive rate of P16 was 53.13% and its expression was related to age, histological grade and FIGO stage (P < 0.05). There was an inverse correlation between Cyclin D1 and P16, r = -0.4007 (P < 0.01).


CONCLUSIONS
Cyclin D1 and P16 had cooperative effect and may play an important role in the development and progression of endometrial carcinoma.
Xiong
J
J
Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041, China.
Peng
Z
Z
Yang
K
K
D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002453:Cell Cycle; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis* / Q000235:genetics; D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged
D019941:Cyclin-Dependent Kinase Inhibitor p16; D019938:Cyclin D1