title: A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program.
abstract: BACKGROUND
  Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives).
  
  
  METHODS
  The evidence was synthesized using meta-analysis.
  
  
  RESULTS
  Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage.
  
  
  CONCLUSIONS
  No regions show uniformly large effects on BP/hypertension in all populations.
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA. mike@wubios.wustle.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Province
authors.forename: Sharon L R
authors.initials: SL
authors.lastname: Kardia
authors.forename: Koustubh
authors.initials: K
authors.lastname: Ranade
authors.forename: Dabeeru C
authors.initials: DC
authors.lastname: Rao
authors.forename: Bonnie A
authors.initials: BA
authors.lastname: Thiel
authors.forename: Richard S
authors.initials: RS
authors.lastname: Cooper
authors.forename: Neil
authors.initials: N
authors.lastname: Risch
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Turner
authors.forename: David R
authors.initials: DR
authors.lastname: Cox
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.forename: Alan B
authors.initials: AB
authors.lastname: Weder
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D019992:Databases as Topic; D008040:Genetic Linkage; D015894:Genome, Human; D006078:Government Programs; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008126:Lod Score; D009316:National Institutes of Health (U.S.); D014481:United States