Conjugates of aberrant gangliosides in antiglioma vaccine: toxicological assay.
We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings substantiated the necessity of father development of this method of vaccination. The vaccine should undergo clinical tests in patients with malignant gliomas.
Lombardi
V
V
University of Bari, Institute of Pathological Anatomy, Italy. vinlombardi@libero.it
Shnaar
R
R
Minev
B
B
Misasi
R
R
Gitstsi
Kh
Kh
Sorice
M
M
Troncone
A
A
D000818:Animals; D019496:Cancer Vaccines / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005732:Gangliosides / Q000276:immunology* / Q000378:metabolism; D005910:Glioma / Q000276:immunology / Q000378:metabolism; D006433:Hemocyanins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology* / Q000633:toxicity
D019496:Cancer Vaccines; D005732:Gangliosides; D018074:Vaccines, Conjugate; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin