[Experimental study on allogeneic mandible transplantation combined with basic fibroblast growth factor]
OBJECTIVE: To study the effect of basic fibroblast growth factor(b-FGF) on revascularization and bone remodeling of allogeneic mandible transplantation in repair of mandible defects in rabbits. METHODS: The mandible defects of 20 adult rabbits were created in both sides. The defects on the left side were implanted with allogeneic bone and local administration of b-FGF; the defects on the right side were only repaired with allogeneic bone as control group. At 1, 3 months after operation, the revascularization and bone remodeling were observed by ink-gelation vascular perfusion-transparency and histological examination. RESULTS: The allogeneic bone and b-FGF group had more marked vascularization and more quick and complete bone formation than control group. CONCLUSION: b-FGF can improve revascularization and bone formation after allogeneic mandible transplantation; allogeneic bone combined with b-FGF is a promising bone substitute in clinical uses.
Zhu
Hui-Yong
HY
The First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China.
Wu
Qiu-Liang
QL
Zhang
Ming
M
Hu
Ji-An
JA
Chao
Zhi-Qiang
ZQ
Li
Song-Ying
SY