title: The effect of in utero hypoxia on fetal heart and brain trace metals.
abstract: This study determined the effect of in utero hypoxia on fetal heart and brain pro- and antioxidant trace metals. Dunkin-Hartley guinea pigs (50-60 days gestation) were exposed to 1 h hypoxia (7% O2/93% N2) followed by 4 h reoxygenation in room air. Fetal hearts and brains were harvested and analyzed for copper, iron, magnesium and zinc. Fetal brain iron was significantly increased 28% after hypoxia and 35% by 1 h posthypoxia. Fetal brain magnesium demonstrated progressive decreases of 18% by 4 h posthypoxia. No significant effects of hypoxia were observed on heart trace metals. These results indicate that prooxidant metals may be increased and antioxidant metals may be decreased in posthypoxic fetal brain during a time when these tissues may be vulnerable to oxidative injury.
authors.affiliation: Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, USA. spowell@lij.edu
authors.forename: Saul R
authors.initials: SR
authors.lastname: Powell
authors.forename: Sayed Emal
authors.initials: SE
authors.lastname: Wahezi
authors.forename: Dev
authors.initials: D
authors.lastname: Maulik
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001921:Brain / Q000196:embryology*; D001923:Brain Chemistry; D003300:Copper / Q000032:analysis; D005260:Female; D005318:Fetal Heart / Q000737:chemistry*; D005311:Fetal Hypoxia / Q000378:metabolism*; D005333:Fetus; D006168:Guinea Pigs; D007501:Iron / Q000032:analysis; D008274:Magnesium / Q000032:analysis; D016877:Oxidants / Q000032:analysis; D010084:Oxidation-Reduction; D011247:Pregnancy; D014131:Trace Elements / Q000032:analysis*; D015032:Zinc / Q000032:analysis
chemical_list: D000975:Antioxidants; D016877:Oxidants; D014131:Trace Elements; D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc