[Relationship between the genotypes of hepatitis B virus and the severity of liver diseases].
OBJECTIVE
To investigate the relationship between different genotypes of hepatitis B virus (HBV) and the severity of liver diseases.


METHODS
The S nucleotide sequences of HBV strains isolated from plasma samples of 284 patients were detected and compared. Among them, 87 patients were HBV asymptomatic carriers (ASC), 157 chronic hepatitis B (CHB), 22 liver cirrhosis (LC), and 18 hepatocellular carcinoma (HCC).


RESULTS
Genotypes B and C were predominant, with a 26.1% proportion and a 63.2% proportion respectively. The percentage of genotypes B and C in patients with ASC, CHB, LC, and HCC were significantly different (x(2)=15.09, P<0.001). Compared with genotype B, genotype C was more common in patients with CHB and HCC (59.6% vs 43.2%, chi(2)=10.87, P<0.001; 7.7% vs 1.4%, x(2)=7.41, P<0.001), but in patients with LC there was no different (7.7% vs 8.1%, chi(2)=1.29, P>0.05).


CONCLUSIONS
This study suggests that genotype B and C are predominant. And genotype C may induce more severe the liver inflammation than genotype B may do.
Xu
Jun
J
Institute of Liver Diseases and People's Hospitol, Beijing University, Beijing 100044, China.
Wang
Qi Xin
QX
Jiang
Dong
D
Yang
Liu Ming
LM
Zhao
Yan Long
YL
Chen
Hong Song
HS
Wei
Lai
L
D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors