Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly.
We analyzed neuronal phenotypes and dendritic growth in the newborn with semilobar holoprosencephaly and 18p deletion. We found that the holoprosencephalic neocortex retained its basic six-layered lamination but displayed a number of intralaminar and modular architectonic alterations and contained a mixture of normal and aberrant neuronal phenotypes. The most conspicious finding was the presence of the pronounced increase in soma size and total basal dendritic length of holoprosencephalic layer III pyramidal neurons in comparison to age-matched control brains. The dramatic (5-fold) dendritic overgrowth observed in associative cortico-cortical pyramidal neurons is probably related to the pronounced diminution of the cortical afferent input.
Judas
Milos
M
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 12, 10000 Zagreb, Croatia.
Rasin
Mladen Roko
MR
Kruslin
Bozo
B
Kostović
Kresimir
K
Jukić
Drazen
D
Petanjek
Zdravko
Z
Kostović
Ivica
I
D000110:Acetylcholinesterase / Q000378:metabolism; D003712:Dendrites / Q000473:pathology; D005260:Female; D016142:Holoprosencephaly / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D019579:Neocortex / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology*
D000110:Acetylcholinesterase