t(5;9)(q11;q34): a novel familial translocation involving Abelson oncogene and association with hypereosinophilia.
A 6-year-old girl with hypereosinophilia was found to have a familial constitutional translocation t(5;9)(q11;q34). Flow cytometry and gene rearrangement studies did not show any clonal T-helper cell proliferation. Presence of cryptic Philadelphia translocation was ruled out by reverse transcription polymerase chain reaction. Abelson oncogene translocation on chromosome 5 was confirmed by fluorescent in situ hybridization. This is the first example of a familial translocation involving the abelson oncogene and association with hypereosinophilia. The authors discuss a novel mechanism of hypereosinophilia involving the hybrid product of the abelson oncogene with an unknown partner gene on chromosome 5 (probably granzyme-A).
Bakhshi
Sameer
S
Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, 39012 Beaubien Boulevard, Detroit, MI 48201, USA.
Hamre
Merlin
M
Mohamed
Anwar N
AN
Feldman
Gerald
G
Ravindranath
Yaddanapudi
Y
D002648:Child; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics* / Q000473:pathology; D017404:In Situ Hybridization, Fluorescence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics*