Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Three new malyngamides, U (1), V (2), and W (3), all possessing an uncommon oxygenation pattern, have been isolated from the marine cyanobacterium Lyngbya majuscula collected in Papua New Guinea. The planar structures of these compounds were deduced from NMR data. Aspects of their relative stereochemistry were investigated using selective (1)H decoupling, 1D and 2D NOESY, and E-COSY experiments in three different NMR solvents.
McPhail
Kerry L
KL
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Gerwick
William H
WH
D000818:Animals; D001156:Artemia / Q000187:drug effects; D000458:Cyanobacteria / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D003512:Cyclohexanones; D005229:Fatty Acids, Monounsaturated; C474704:malyngamide U; C474706:malyngamide V; C474705:malyngamide W