title: Reference values for the bone marrow aspirates in adult dogs.
abstract: Reference ranges for each cell type and six different ratios (M : E ratio = quotient of number of myeloid cells/erythroid precursors; different maturation ratios) were calculated for bone marrow aspirates of adult dogs. These values were based on 2.5 and 97.5% percentiles of differentials of 1000 cells in bone marrow aspirates of 92 healthy 1-8-year-old dogs. The results of intact male and female dogs were compared. No distinct sex-related differences were found (P > 0.05). A wide physiological range was observed in almost all bone marrow cells resulting in broad reference ranges for the ratios. The clinically relevant M : E ratio varied between 0.45 and 2.87. The accurate cytological examination of bone marrow based on the reference ranges presented in this study requires preparation of high-quality bone marrow films with minimal blood contamination.
authors.affiliation: Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany. reinhard.mischke@tiho-hannover.de
authors.forename: R
authors.initials: R
authors.lastname: Mischke
authors.forename: L
authors.initials: L
authors.lastname: Busse
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000145:classification* / Q000166:cytology*; D001856:Bone Marrow Examination / Q000662:veterinary; D004285:Dogs / Q000502:physiology*; D005260:Female; D008297:Male; D012016:Reference Values