Decreased levels of fibrinogen in very high parity women.
OBJECTIVE
To evaluate coagulation parameters in healthy pregnant grand grand multiparous women.


METHODS
Prothrombin time (PT), activated partial thromboplastin time (PTT), fibrinogen, D-dimer, albumin and blood lipids were prospectively determined in 50 pregnant grand grand multiparas (> or =9 deliveries) and 50 age-matched pregnant women with low parity (< or =3 deliveries).


RESULTS
The average concentrations of fibrinogen in the grand grand multiparas were 4.0+/-0.6 as compared to 4.7+/-0.7 g/l in the control group (P<0.001). In both groups D-dimer levels were >1000 ng/ml and the concentrations of albumin, triglycerides, cholesterol, high-density lipoprotein (HDL) were not significantly different.


CONCLUSIONS
In healthy pregnant grand grand multiparous women fibrinogen levels are lower than in age-matched women with low parity. These changes are not directly associated with lipids metabolism during pregnancy.
Almagor
Miriam
M
Division of Clinical Laboratories, Bikur Cholim Hospital, 5 Strauss Street, 91004, Jerusalem, Israel. almagors@hotmail.com
Gorten
Diana
D
Yaffe
Haim
H
D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D010298:Parity / Q000502:physiology*; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011446:Prospective Studies; D011517:Prothrombin Time; D012709:Serum Albumin / Q000378:metabolism
D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; D012709:Serum Albumin; C036309:fibrin fragment D; D005340:Fibrinogen; D002784:Cholesterol