title: [Assessment of the status of biological health of the population of tundra Nentsy inhabiting northwestern Siberia from data on analysis of autoantibodies and lipoproteins from blood donors].
abstract: As a result of large-scale nuclear explosion on Novaya Zemlya test site (1955-62) the Tundra Nentsy population of Yamal-Nentsy autonomous region (YNAR) fell under constant influence of incorporated radioactive isotopes (137Cs and 90Sr). Therefore, it is very important to analyze a possible spectrum of diseases of Tundra Nentsy population. We have developed recently a new method for determination of concentrations of all main fraction and subfraction of lipoproteins (LP, 30 parameters) in human sera using small-angle X-ray scattering, and a general mathematical model to describe LP composition in human blood. The analysis of the 30 parameters characterizing fine spectrum of LPs in 374 YNAR natives showed that only approximately 10% of the donors are normal, while the indices for approximately 90% of the test subjects fall into the range of different pathologies (3-8% incidence in normal population, according to epidemiological studies). Moreover, we found that approximately 41% of European and approximately 56% of Tundra Nentsy have high level of autoantibodies to DNA and cardiolopine like the same for autoimmune diseases patients.
authors.affiliation: Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of Russian Akademy of Sciences, Novosibirsk, 630090 Russia. nevinsky@niboch.nsc.ru
authors.forename: G A
authors.initials: GA
authors.lastname: Nevinskiĭ
authors.forename: L P
authors.initials: LP
authors.lastname: Osipova
authors.forename: E S
authors.initials: ES
authors.lastname: Korovkina
authors.forename: F V
authors.initials: FV
authors.lastname: Tuzikov
authors.forename: N A
authors.initials: NA
authors.lastname: Tuzikova
authors.forename: N V
authors.initials: NV
authors.lastname: Garmashova
authors.forename: V N
authors.initials: VN
authors.lastname: Buneva
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D006305:Health Status Indicators; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D012542:Scattering, Radiation; D012800:Siberia / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D008074:Lipoproteins