Relationship between alcohol motivation and ethanol sensitivity and blood and brain catecholamine content in the progeny of rats preferring and nonpreferring alcohol.
A system of neurochemical signs indicating predisposition to high ethanol consumption is formed in the third generation descendants of ethanol-preferring male rats. Risk-group males are detected (with 95% probability) by the content of dopamine and norepinephrine and their ratio in the brain. Alcohol motivation depends on blood epinephrine content reflecting individual sensitivity to stress.
Anokhina
I P
IP
Institute of Drug Abuse, Ministry of Health of Russian Federation, Moscow, Russia.
Stanishevskaya
A V
AV
L'vova
O F
OF
Veretinskaya
A G
AG
Khristolyubova
N A
NA
D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology; D000437:Alcoholism / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood / Q000378:metabolism*; D003433:Crosses, Genetic; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D009042:Motivation; D051381:Rats; D012680:Sensitivity and Specificity; D013315:Stress, Psychological
D002395:Catecholamines; D000431:Ethanol