title: A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients.
abstract: Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, Scotland, UK.
authors.forename: Roma
authors.initials: R
authors.lastname: Maguire
authors.forename: Donald C
authors.initials: DC
authors.lastname: McMillan
authors.forename: A Michael
authors.initials: AM
authors.lastname: Wallace
authors.forename: Colin
authors.initials: C
authors.lastname: McArdle
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary*; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000368:Aged; D001066:Appetite; D001823:Body Composition; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis
chemical_list: D007328:Insulin; D020738:Leptin; D012709:Serum Albumin; D002097:C-Reactive Protein; D006854:Hydrocortisone