[Detection of EBV-DNA, EBNA2 and LMP-1 in tumor tissues of han and uygur patients with nasopharyngeal carcinoma in Xinjiang].
OBJECTIVE
To investigate the possible differences of human nasopharyngeal carcinogenesis between Han and Uygur patients in xinjiang.


METHODS
Detection of EBV-DNA, EBNA2 and LMP-1 in tumor tissues of 73 patients (Han 41, uygur 32) with nasopharyngeal carcinoma (NPC) were performed by PCR and immunohistochemistry.


RESULTS
Tho positive rate of EBV-DNA, EBNA2 expression was 48.2%(20/41), 43.9% (18/41) in Han and 59.3%(19/32), 43.7%(14/32) in Uygur respectively, no significant difference was found (P > 0.05). Expression of LMP-1 in NPC, in both positive and negative EBV-DNA specimens, was higher in Uygur (78.9%) than that in Han (40%) (P < 0.05),


CONCLUSIONS
The EBV infection may involve in nasopharyngeal carcinogenesis in xinjiang; the LMP-1 of EBV could be a more critical factor in malignant transformation of normal nasopharyngeal epithelium in uygur people than in han Chinese.
Li
T Y
TY
Department of ENT, First Teaching Hospital of Xinjiang Medical University, Urumqi 830000.
Lu
X M
XM
Su
S W
SW
Mu
N R
NR
Shen
B Y
BY
Pa
T M
TM
Chen
Z L
ZL
D000293:Adolescent; D000328:Adult; D044466:Asian People; D002648:Child; D002681:China / Q000208:ethnology; D004279:DNA, Viral / Q000032:analysis*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000821:virology*; D016133:Polymerase Chain Reaction; D044465:White People
D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens