Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers.
This study investigated the effects of continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on functional hemispheric differences, as indexed by quantitative electroencephalographic (EEG) asymmetry and coherence measures. Twenty-four adult volunteers (15 females and 9 males) were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel-group design, with EEG being recorded before and during (10 and 40 min) a 60-min infusion period. No significant treatment differences were observed for absolute EEG power but, compared to placebo, CCK-4 infusion increased asymmetry and reduced coherence of slow-wave activity at midtemporal recording sites. These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD).
Knott
Verner
V
Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada. vknott@rohcg.on.ca
Mahoney
Colleen
C
Bradwejn
Jacques
J
Shlik
Jakov
J
Gunnarsson
Tove
T
D000293:Adolescent; D000328:Adult; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016584:Panic Disorder / Q000503:physiopathology; D010919:Placebos; D013702:Temporal Lobe / Q000187:drug effects / Q000502:physiology*
D010919:Placebos; D002766:Cholecystokinin