title: CFTR and bicarbonate secretion by [correction of to] epithelial cells.
abstract: Defective HCO(3)(-) and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO(3)(-) secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO(3)(-).
authors.affiliation: Institute of Physiology, University of Münster, D-48149 Münster, Germany.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hug
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tamada
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Bridges
mesh_terms: D001639:Bicarbonates / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans
chemical_list: D001639:Bicarbonates; C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator