Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.
Trudeau
Jacqueline D
JD
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Kelly-Smith
Carolyn
C
Verchere
C Bruce
CB
Elliott
John F
JF
Dutz
Jan P
JP
Finegood
Diane T
DT
Santamaria
Pere
P
Tan
Rusung
R
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism; D007515:Islets of Langerhans / Q000276:immunology; D018655:Lymphocyte Count; D051379:Mice; D016688:Mice, Inbred NOD
D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I