title: New thoughts on sepsis: the unifier of critical care.
abstract: In the United States, more than $16 billion annually is spent managing patients with severe sepsis and its sequelae. Insight into the inflammatory response, endothelial tissue, and the coagulation cascade suggest promising new treatment regimens that limit morbidity and mortality due to sepsis and multisystem organ failure. This article will discuss new information regarding the pathophysiology of the inflammatory response and sepsis. Current thoughts on clinical management and a promising new agent, Activated Protein C, will be presented.
authors.affiliation: Clinical Education, Harborview Medical Center, Mailstop 359733, 325 Ninth Avenue, Seattle, WA 98102, USA. schulman@u.washington.edu
authors.forename: Christine Smith
authors.initials: CS
authors.lastname: Schulman
authors.forename: Kathy
authors.initials: K
authors.lastname: Hare
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004727:Endothelium / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000150:complications / Q000628:therapy; D017410:Practice Guidelines as Topic; D011486:Protein C / Q000502:physiology / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D018805:Sepsis / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated