Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds.
Silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% were compared to assess the antibacterial effect of a once-daily application on experimental rat 15% full-skin thickness burn wounds seeded 24 hours earlier with a 10 standard strain of methicillin-resistant staphylococci. The quantitative counts of seeded organism in burn eschar and subjacent muscle were determined at postburn day 7, beside the cultures of blood and lung biopsies. All tested topical agents were equally effective against methicillin-resistant in reducing local burn wound bacterial count and preventing systemic infection.
Acikel
Cengiz
C
Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Oncul
Oral
O
Ulkur
Ersin
E
Bayram
Ismail
I
Celikoz
Bahattin
B
Cavuslu
Saban
S
D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002056:Burns / Q000150:complications* / Q000188:drug therapy*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005672:Fusidic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D016106:Methicillin Resistance; D016712:Mupirocin / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D015599:Trauma Severity Indices
D000891:Anti-Infective Agents, Local; D005672:Fusidic Acid; D016712:Mupirocin; D012837:Silver Sulfadiazine