title: Effects of duodenal seal oil administration in patients with inflammatory bowel disease.
abstract: Long-chain n-3 PUFA in fish oil have modulating effects on inflammatory responses. The aim of this open pilot study was to investigate whether duodenal seal oil administration would benefit patients with inflammatory bowel disease (IBD). Seal oil (10 mL) was administered three times a day directly into the distal part of the duodenum via a nasoduodenal feeding tube for 10 d in 10 patients, 5 of whom had Crohn's disease and 5 ulcerative colitis. Nine of the 10 patients suffered from IBD-associated joint pain. Various parameters of disease activity and FA incorporation in tissues were analyzed before and after treatment. Following seal oil therapy, joint pain index, disease activity, and serum cholesterol level were significantly decreased, whereas the n-3 to n-6 ratio both in intestinal biopsies and blood was significantly increased. Measures of calprotectin concentration in gut lavage fluid, intestinal permeability, and lipid peroxidation were not significantly changed. The results suggest positive effects of seal oil in patients with IBD, especially on IBD-associated joint pain. Further controlled studies are warranted.
authors.affiliation: Division of Gastroenterology, Institute of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway. gulen.arslan@med.uib.no
authors.forename: Gülen
authors.initials: G
authors.lastname: Arslan
authors.forename: Linn Anne
authors.initials: LA
authors.lastname: Brunborg
authors.forename: Livar
authors.initials: L
authors.lastname: Frøyland
authors.forename: Johan G
authors.initials: JG
authors.lastname: Brun
authors.forename: Merete
authors.initials: M
authors.lastname: Valen
authors.forename: Arnold
authors.initials: A
authors.lastname: Berstad
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018771:Arthralgia / Q000188:drug therapy; D002908:Chronic Disease; D003092:Colitis / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000188:drug therapy*; D008137:Longitudinal Studies; D008297:Male; D009821:Oils / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D046048:Seals, Earless
chemical_list: D005231:Fatty Acids, Unsaturated; D009821:Oils