title: [Two patients with distant metastases from head and neck squamous cell carcinomas successfully treated with docetaxel and cisplatin].
abstract: Two cases of distant metastases from head and neck squamous cell carcinomas are reported. The patients were treated intravenously with docetaxel (60 mg/m2) in combination with cisplatin (70 mg/m2). The chemotherapy was repeated every three weeks. Both cases showed a remarkable response. A complete response was obtained in one case. Grade 1 nausea and alopecia were observed. One patient had grade 3 neutropenia, which was treated with G-CSF. We herein describe the efficacy of newly developed docetaxel with cisplatin in treating distant metastasis from head and neck cancer.
authors.affiliation: Dept. of Otolaryngology, Tokai University School of Medicine.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakai
authors.forename: Junichi
authors.initials: J
authors.lastname: Onuki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Odagiri
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012074:Remission Induction; D043823:Taxoids
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin