title: Cerebral tissue alterations and daily life stress experience in psychosis.
abstract: OBJECTIVE
  To examine whether the total volumes of cerebrospinal fluid (CSF), cerebral grey matter and white matter were correlated with the experience of environmental stress in daily life situations.
  
  
  METHODS
  Twenty-seven patients with psychosis underwent magnetic resonance imaging scanning and a random time-sampling self-assessment technique (Experience Sampling Method) to determine subjective daily life stress experiences. Total cerebral tissue volumes were derived from an automated segmentation procedure.
  
  
  RESULTS
  CSF volume was positively associated with daily life event-related stress (beta=0.016, P=0.002), while the association with total white matter was negative (beta=-0.013, P=0.005). The effects were independent of each other and of total cerebral volume and other confounders. No large or significant association was found with grey matter volume.
  
  
  CONCLUSIONS
  Subjective stress experience in daily life is associated with increased CSF and reduced white matter volumes in patients with psychosis, suggesting functional significance of these cerebral measures.
authors.affiliation: Department of Psychiatry and Neuropsychology, azM/Mondriaan/Riagg/RIBW/Vijverdal Academic Centre, European Graduate School of Neuroscience, Maastricht University, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Marcelis
authors.forename: I
authors.initials: I
authors.lastname: Myin-Germeys
authors.forename: J
authors.initials: J
authors.lastname: Suckling
authors.forename: P
authors.initials: P
authors.lastname: Woodruff
authors.forename: P
authors.initials: P
authors.lastname: Hofman
authors.forename: E
authors.initials: E
authors.lastname: Bullmore
authors.forename: P
authors.initials: P
authors.lastname: Delespaul
authors.forename: J
authors.initials: J
authors.lastname: van Os
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D008016:Life Change Events; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000453:epidemiology*; D012494:Sampling Studies; D012647:Self-Assessment; D013315:Stress, Psychological / Q000175:diagnosis / Q000453:epidemiology*