title: Molecular aspects of membrane fission in the secretory pathway.
abstract: Membrane fission is essential in various intracellular dissociative transport steps. The molecular mechanisms by which endocytic vesicles detach from the plasma membrane are being rapidly elucidated. Much less is known about the fission mechanisms operating at Golgi tubular networks; these include the Golgi transport and sorting stations, the trans-Golgi and cis-Golgi networks, where the geometry and physical properties of the membranes differ from those at the cell surface. Here we discuss the lipid and protein machineries that have so far been related to the fission process, with emphasis on those acting in the Golgi complex.
authors.affiliation: Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, Italy. corda@dcbo.negrisud.it
authors.forename: D
authors.initials: D
authors.lastname: Corda
authors.forename: C
authors.initials: C
authors.lastname: Hidalgo Carcedo
authors.forename: M
authors.initials: M
authors.lastname: Bonazzi
authors.forename: A
authors.initials: A
authors.lastname: Luini
authors.forename: S
authors.initials: S
authors.lastname: Spanò
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D034281:Dynamins / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008055:Lipids / Q000502:physiology; D008322:Mammals / Q000502:physiology; D008561:Membrane Fusion / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D010739:Phospholipase D / Q000502:physiology; D049294:Phospholipid Transfer Proteins; D011493:Protein Kinase C / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C119945:Ctbp1 protein, rat; D008055:Lipids; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; C118289:SEC24 protein, S cerevisiae; C107640:SH3GL2 protein, human; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C089212:protein kinase D; D011493:Protein Kinase C; D010739:Phospholipase D; D034281:Dynamins