[Clinical study of capsaicin in the treatment of allergic rhinitis].
OBJECTIVE
To study the clinical effect of capsaicin of nasal administration in 100 cases of allergic rhinitis.


METHODS
Capsaicin was applied by nostril, once 5 days and 5 times as a therapeutic course. Acidophil were measured and nasal airflow resistance was analysed before and after capsaicin therapy.


RESULTS
It showed that nasal symptoms of patients were obviously relieved and 94% of the cases in the measure of acidophil changed to negative from positive. Moreover, capsaicin induced decrease in nasal airflow resistance from (0.6272 +/- 0.3534) kPa.s/L before therapy to (0.4057 +/- 0.2419) kPa.s/L after therapy (P < 0.001). 90 cases of 100 patients were fellowed up one year, the total effective rate was 89%.


CONCLUSIONS
Our study suggests that capsaicin possessed remarkable effects in the treatment of allergic rhinitis; analyse of nasal airflow resistance may be used as one of the objective guideline in the determinant of therapeutic effects.
Zhang
F
F
Department of Otolaryngology, 466 Hospital of PLA, Beijing 100081.
Zhu
X
X
Han
D
D
Wang
H
H
Wang
L
L
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage*; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D002211:Capsaicin