[The application of liquid chromatography in genetic engineering].
The recent development of the molecular conformation, renaturation and intermediates on therapeutic proteins produced in biotechnology is reviewed. It also includs the quality control and in preparation of the therapeutic proteins in large scale by liquid chromatography in down-stream technology. This review includes 42 references.
Liu
T
T
Institute of Modern Separation Science, Shaanxi Provincial Key Laboratory of Modern Separation Science, Northwest University, Xi'an 710069, China.
Geng
X D
XD
D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods*; D005818:Genetic Engineering; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000302:isolation & purification; D008968:Molecular Conformation; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification
D007376:Interleukin-2; D011994:Recombinant Proteins