title: Major-to-ultratrace elements in bone-marrow fluid as determined by ICP-AES and ICP-MS.
abstract: The major-to-ultratrace elements in human bone-marrow fluid were determined by ICP-AES (inductively coupled plasma atomic emission spectrometry), and ICP-MS (inductively coupled plasma mass spectrometry). The bone-marrow fluid sample was centrifuged prior to acid digestion to exclude the bone piece from bone marrow, and then digested with nitric acid. As a result, 20 elements could be determined over the concentration range from 1610 microg g(-1) for Na to 0.00043 microg g(-1) for W. It was found that Fe, Zn and Sb were enriched by ca. 264-, 7- and 15-fold, respectively, in bone-marrow fluid, compared to those in human blood serum. Alkali metals (K, Rb, Cs), except for Na, were also significantly enriched in bone-marrow fluid. Furthermore, the concentrations of various elements, such as Fe, P, Al, Zn, Cu, Se, Zr, Sn, Ag and W, were significantly higher than those in open seawater.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsuura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Inagaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Haraguchi
mesh_terms: D001853:Bone Marrow / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D012623:Seawater / Q000737:chemistry; D014131:Trace Elements / Q000032:analysis* / Q000097:blood
chemical_list: D014131:Trace Elements