title: Yardenone A and B: new cytotoxic triterpenes from the Indian Ocean sponge Axinella cf. bidderi.
abstract: Two new polyepoxysqualene-derived triterpenes, yardenone A (1) and B (2), together with the known yardenone (3) and sodwanone A (4), have been isolated from the marine sponge Axinella cf. bidderi from Yemen's Socotra Island in the Indian Ocean. The structures were elucidated using spectroscopic data. The relative stereochemistry was established by the analysis of ROESY spectra as well as coupling constants and molecular modeling. Furthermore, the absolute configuration of 1 was confirmed by the advanced Mosher's method. The cytotoxicity of these compounds was evaluated against a NSCLC cell line.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR-CNRS 6001, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carletti
authors.forename: Christophe
authors.initials: C
authors.lastname: Long
authors.forename: Corinne
authors.initials: C
authors.lastname: Funel
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D015006:Yemen
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; C474000:yardenone A; C474001:yardenone B