[Calcium dependent synaptic plasticity].
Recent work shows that the intracellular free Ca2+ concentrations ([Ca2+]i) of the presynaptic and postsynaptic neurons play crucial signaling roles in short- and long-term synaptic plasticity. Residual [Ca2+]i followed conditioning stimulation may cause short-term synaptic enhancement. Presynaptic [Ca2+]i could influence the replacing of presynaptic depressed vesicles, as well as encode the precise relative timing of presynaptic input and postsynaptic activity and generate long-term synaptic modification of opposite polarity(LTP or LTD).
Dou
Y
Y
Department of Pathophysiology, Qingdao Medical College, Qingdao 266021.
Yan
J
J
Wu
Y Y
YY
Cui
R Y
RY
Lu
C L
CL
D000818:Animals; D002118:Calcium / Q000502:physiology*; D006801:Humans; D017774:Long-Term Potentiation; D009473:Neuronal Plasticity / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D002118:Calcium