Egg white protein-bonded columns and their applications.
Egg white protein-bonded columns were developed for HPLC. These columns can be used under aqueous mobile phase and separate various kinds of drug enantiomers. Hyphenated techniques using protein-bonded columns with LC/MS and/or column switching have been recognized as integral methods in pharmaceutical research to analyze drug enantiomers. Therefore, these methods are very useful for research fields of pharmacokinetics and pharmacology.
Oda
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Laboratory of Seeds Finding Technology, Eisai Co. Ltd, Tsukuba Ibaraki 300-2635, Japan. y-oda@hhc.eisai.co.jp
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification; D001360:Avidin; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D003207:Conalbumin; D000077265:Donepezil; D004529:Egg White; D005420:Flavoproteins; D007189:Indans / Q000097:blood* / Q000302:isolation & purification; D007660:Ketoprofen / Q000097:blood / Q000302:isolation & purification*; D010880:Piperidines / Q000097:blood* / Q000302:isolation & purification; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005420:Flavoproteins; D007189:Indans; D010880:Piperidines; D003207:Conalbumin; D001360:Avidin; D000077265:Donepezil; D007660:Ketoprofen