title: A new platelet parameter, the mean platelet component, can demonstrate abnormal platelet function and structure in myelodysplasia.
abstract: The mean platelet component (MPC) is a new platelet parameter generated by the Bayer ADVIA 120 full blood count analyser as part of the routine complete blood count (CBC) test cycle. We report a case of myelodysplasia with bleeding complications and abnormal template bleeding time in whom low mean platelet component parameters were associated with partial platelet granule deficiency, demonstrated by transmission electron microscopy. We suggest that the mean platelet component is an inexpensive and rapid test to screen for platelet dysfunction related to ultrastructural abnormalities in myelodysplasia.
authors.affiliation: Department of Haematology, Rotherham General Hospitals NHS Trust, Rotherham, S60 2UD, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Brummitt
authors.forename: H F
authors.initials: HF
authors.lastname: Barker
authors.forename: N
authors.initials: N
authors.lastname: Pujol-Moix
mesh_terms: D001791:Blood Platelet Disorders / Q000175:diagnosis / Q000473:pathology*; D001792:Blood Platelets / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications*; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods*