title: Clinical outcomes after laparoscopic antireflux surgery in patients with and without preoperative endoscopic esophagitis.
abstract: A wide spectrum of endoscopic findings exists in patients with gastroesophageal reflux disease (GERD). This study compared clinical outcomes after laparoscopic antireflux surgery (LARS) in patients who had GERD with and without preoperative endoscopic esophagitis. From 1992 to 2001, a total of 414 patients who underwent LARS with 6 months or more of follow-up were prospectively entered into a database. Among these patients, 84 (20%) had no endoscopic evidence of esophagitis on preoperative endoscopy (group 1), whereas 330 (80%) did have esophagitis (group 2). Perioperative outcomes, GERD symptom relief, and the use of acid-reducing medication were assessed. Preoperative DeMeester scores in groups 1 and 2 were 44 +/- 29 and 61 +/- 62 (P < 0.05) and mean esophageal peristaltic amplitude was 86 +/- 32 mm Hg vs. 60 +/- 42 mm Hg, respectively (P < 0.05). Although procedure time was significantly shorter in group 1, other perioperative outcomes were similar. At postoperative follow-up, the use of proton pump inhibitors was reduced in both groups (86% to < or =14%). With the exception of postoperative dysphagia, there was no difference in GERD symptom relief between groups 1 and 2. The presence or absence of preoperative esophagitis has minimal effect on favorable symptomatic outcomes after LARS. Thus LARS is an effective treatment option for patients, irrespective of endoscopic evidence of esophagitis, leading to excellent symptom relief and a marked reduction in the use of proton pump inhibitors.
authors.affiliation: Department of Surgery, Washington University School of Medicine, 4940 Parkview, Room 4449, WUMS Box 8109, 63110, St. Louis, MO.
authors.forename: Ketan M
authors.initials: KM
authors.lastname: Desai
authors.affiliation: Department of Surgery, Washington University School of Medicine, 4940 Parkview, Room 4449, WUMS Box 8109, 63110, St. Louis, MO.
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Frisella
authors.affiliation: Department of Surgery, Washington University School of Medicine, 4940 Parkview, Room 4449, WUMS Box 8109, 63110, St. Louis, MO. sopern@msnotes.wustl.edu.
authors.forename: Nathaniel J
authors.initials: NJ
authors.lastname: Soper
mesh_terms: D001471:Barrett Esophagus / Q000150:complications; D004942:Esophagitis, Peptic / Q000150:complications* / Q000175:diagnosis; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications / Q000601:surgery*; D006801:Humans; D007431:Intraoperative Complications; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011446:Prospective Studies; D016896:Treatment Outcome