title: Renal impairment in patients with ovarian cancer.
abstract: OBJECTIVE
  To investigate the prevalence of renal impairment in patients with ovarian cancer at the time of the diagnosis.
  
  
  METHODS
  Creatinine clearance was estimated according to Cockcroft and Gault (C&G Ccr), glomerular filtration rate (GFR) was determined as renal clearance of 99mTc-DTPA, and renal ultrasound was performed in 60 consecutive patients with newly diagnosed ovarian cancer.
  
  
  RESULTS
  A 28% of the total population studied had a GFR <60 ml/min/1.73 m(2). A moderate/severe dilation of the upper urinary tract was found in 12% of patients. The length of kidneys ranged between 9.0 and 13.5 cm, and a statistically significant correlation was found between kidney length and values of GFR.
  
  
  CONCLUSIONS
  A reduction in renal function and a moderate to severe dilation of upper urinary tract frequently occur in patients with ovarian cancer at the time of the diagnosis.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, University of Pisa, I-56100, Pisa, Italy. cd.donadio@med.unipi.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Donadio
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lucchesi
authors.forename: Michela
authors.initials: M
authors.lastname: Ardini
authors.forename: Stefania
authors.initials: S
authors.lastname: Cosio
authors.forename: Angiolo
authors.initials: A
authors.lastname: Gadducci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications*; D014463:Ultrasonography
chemical_list: D003404:Creatinine