title: [Determination of sotalol hydrochloride by reversed-phase high performance liquid chromatography].
abstract: An RP-HPLC method for determination and detection of sotalol hydrochloride is described. The baseline separation was achieved on ODS column within 15 minutes by using 0.1% HAc-acetonitrile (80:20, V/V) as mobile phase at a flow rate 1.5 mL/min, and the wavelength was set at 227 nm. The linear range was 5-45 mg/L (r = 0.9991) and the limit of detection was 1 mg/L(S/N > 3). The intra-day and inter-day RSDs were 0.20% and 0.93% respectively.
authors.affiliation: College of Pharmacy, Shandong Medical University, Jinan 250062, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Wang
authors.forename: G S
authors.initials: GS
authors.lastname: Zhao
authors.forename: W L
authors.initials: WL
authors.lastname: Jiang
authors.forename: A X
authors.initials: AX
authors.lastname: Zuo
authors.forename: H T
authors.initials: HT
authors.lastname: Bi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013015:Sotalol / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D000319:Adrenergic beta-Antagonists; D013015:Sotalol