Is HIV sequestered in bone? Possible implications of virological and immunological findings in some HIV-infected patients with bone disease.
To determine the prevalence of CD4 lymphocyte levels less than 350 cells/mm3 accompanying viral loads (VL) less than 500 copies/ml (discordant CD4 lymphocyte levels/VL) in HIV-infected men with bone pathologies, we conducted a review of the records of 3512 men. We found discordant CD4 lymphocyte levels/VL in 26 (36.1%) out of 72 with bone pathologies, and in 704 (20.5%) out of 3440 without bone pathologies (P < 0.01), and concluded that HIV sequestered in bone was a possible explanation.
Fessel
W Jeffrey
WJ
HIV Research Unit, San Francisco, CA, USA.
Hurley
Leo B
LB
D001847:Bone Diseases / Q000821:virology*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D008297:Male; D019562:Viral Load