[Lectin activity of antitumor substances synthesized by Bacillus subtilis B-7025].
Nutrient medium, which is optimal for synthesis of biologically active substances and allows obtaining stable outflow of Bacillus subtilis B-7025 to the culture medium, has been selected under the conditions of the bacillus periodic cultivation. It has been established that these substances are extracellular lectins with high activity and carbohydrate specificity to fructose-1.6-di phosphate, N-acetylneuraminic acid and glucose derivatives: D-glucuronic acid and D-glucosamine.
Podgorskiĭ
V S
VS
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
Kovalenko
E A
EA
Get'man
E I
EI
Potebnia
G P
GP
Tanasienko
O A
OA
D000970:Antineoplastic Agents / Q000032:analysis* / Q000378:metabolism; D001412:Bacillus subtilis / Q000254:growth & development / Q000378:metabolism*; D003470:Culture Media; D005635:Fructosediphosphates / Q000737:chemistry; D005944:Glucosamine / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006388:Hemagglutinins / Q000032:analysis* / Q000096:biosynthesis; D037102:Lectins / Q000032:analysis* / Q000096:biosynthesis; D019158:N-Acetylneuraminic Acid / Q000737:chemistry; D013045:Species Specificity
D000970:Antineoplastic Agents; D003470:Culture Media; D005635:Fructosediphosphates; D006388:Hemagglutinins; D037102:Lectins; D020723:Glucuronic Acid; D019158:N-Acetylneuraminic Acid; C029063:fructose-1,6-diphosphate; D005944:Glucosamine