Neoplasia of the tongue in a patient with Crohn's disease treated with azathioprine: case report.
Azathioprine is now widely used for the maintenance treatment of Crohn's disease, but there are concerns whether azathioprine could predispose to malignancy in patients with inflammatory bowel disease. We report here a case of a 39-year-old non-smoking male with Crohn's disease who had been treated for 3 years with azathioprine and developed a lingual ulcer. Biopsy revealed squamous cell carcinoma, a tumour not previously associated with Crohn's disease.
Li
Andy C Y
AC
Gastrointestinal Laboratory, The Rayne Institute, St Thomas' Hospital, Lambeth Road, London SE1 7EH, UK.
Warnakulasuriya
Saman
S
Thompson
Richard P H
RP
D000328:Adult; D000963:Antimetabolites / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects*; D002278:Carcinoma in Situ / Q000139:chemically induced* / Q000473:pathology; D003424:Crohn Disease / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D000963:Antimetabolites; D001379:Azathioprine