title: Computational fluid dynamics analysis of an intra-cardiac axial flow pump.
abstract: A low rate of hemolysis is an important factor for the development of a rotary blood pump. It is, however, difficult to identify the areas where hemolysis occurs. Computational fluid dynamics (CFD) analysis enables the engineer to predict hemolysis on a computer. In this study, fluid dynamics throughout intracardiac axial flow pumps with different designs were analyzed three-dimensionally using CFD software. The computed pressure-flow characteristics of the pump were in good agreement with the measurements. The Reynolds shear stress was computed along particle trace lines. Hemolysis was estimated on the basis of shear stress (tau) and its exposure time (Deltat): dHb/Hb = 3.62 x 10(-7)(tau)(i)(2.416) x Delta(t)(i)(0.785). Particle damage increased with time along the particle trace lines. Hemolysis of each of the pumps was measured in vitro. The computed hemolysis values were in good agreement with the experimental results. CFD is a useful tool for developing a rotary blood pump.
authors.affiliation: Tomakomai National College of Technology, Tomakomai, Hokkaido, Japan. amitoh@me.tomakomai-ct.ac.jp
authors.forename: Ayumi
authors.initials: A
authors.lastname: Mitoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yano
authors.forename: Kazumitsu
authors.initials: K
authors.lastname: Sekine
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Okamoto
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yozu
authors.forename: Shiaki
authors.initials: S
authors.lastname: Kawada
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology; D006354:Heart, Artificial; D006439:Hemodynamics / Q000502:physiology; D006461:Hemolysis / Q000502:physiology*; D018056:Hemorheology; D006801:Humans; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D033081:Shear Strength