[Study on the association between HPV16/18 and expression of p53 protein in laryngeal papillomas].
OBJECTIVE
To understand the relationship between the expression of p53 protein and HPV16/18 infection in laryngeal papillomas.


METHODS
Using PCR and immunohistochemistry techniques examined the paraffin embedded tissues of 35 cases of laryngeal papillomas.


RESULTS
Showed that HPV16/18-DNA were found in 24 cases of laryngeal papillomas (68.8%); overexpression of p53 protein were detected in 19 cases (54.3%); both of HPV16/18-DNA and overexpression of p53 protein were demonstrated in 12 cases of laryngeal papillomas (34.3%).


CONCLUSIONS
This study suggests that HPV16/18 infection and p53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and p53 mutation in tissues of laryngeal papillomas remains to be clarified.
Chu
H Q
HQ
Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Reyt
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D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000821:virology*; D008297:Male; D010212:Papilloma / Q000378:metabolism / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D004279:DNA, Viral; D016159:Tumor Suppressor Protein p53