title: Seroprevalence of hepatitis B virus infection in individuals with clinical evidence of hepatitis in Goiânia, Goiás. Detection of viral DNA and determination of subtypes.
abstract: The presence of serological markers for hepatitis B virus (HBsAg, anti-HBc IgM and Anti-HBc total) was investigated in the serum of 1,396 individuals who had clinical suspect of hepatitis. It was observed that 50.7% of the individuals were positive and, from the total of the studied individuals, 14.5% were positive for HBsAg. From these, 8.5% were also positive for anti-HBc IgM. The analysis in relation to gender showed a higher seroprevalence index among male individuals (p < 0.0001). It was observed the occurrence of subtypes adw2 (62.7%), ayw3 (23.5%), ayw2 (9.8%) and adw4 (3.9%). The viral DNA was detected in 61 (33.9%) HBsAg positive samples and in one sample positive only for anti-HBc total. These results indicate an important incidence of the HBV infection in this population, and reinforce previous studies regarding this virus in the central west region of Brazil.
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Claudia de Oliveira e
authors.initials: Cde O
authors.lastname: Silva
authors.forename: Marli da Silva Pereira
authors.initials: Mda S
authors.lastname: Azevedo
authors.forename: Célia Maria de Almeida
authors.initials: CM
authors.lastname: Soares
authors.forename: Regina Maria Bringel
authors.initials: RM
authors.lastname: Martins
authors.forename: Carmen Helena
authors.initials: CH
authors.lastname: Ramos
authors.forename: Roberto Ruhman
authors.initials: RR
authors.lastname: Daher
authors.forename: Divina das Dôres de Paula
authors.initials: Dd
authors.lastname: Cardoso
mesh_terms: D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000302:isolation & purification; D006511:Hepatitis B Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D016036:Seroepidemiologic Studies; D012703:Serotyping
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens