title: Targeted retroviral infection of tumor cells by receptor cooperation.
abstract: Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.
authors.affiliation: Department of Immunology and Molecular Pathology, Windeyer Institute, 46 Cleveland Street, London W1T 2AH, United Kingdom.
authors.forename: Francisco
authors.initials: F
authors.lastname: Martin
authors.forename: Simon
authors.initials: S
authors.lastname: Chowdhury
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Neil
authors.forename: Kerry A
authors.initials: KA
authors.lastname: Chester
authors.forename: Francois-Loic
authors.initials: FL
authors.lastname: Cosset
authors.forename: Mary K
authors.initials: MK
authors.lastname: Collins
mesh_terms: D000912:Antibodies, Neoplasm / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005822:Genetic Vectors; D006801:Humans; D007128:Immunoglobulin Fragments / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008979:Moloney murine leukemia virus / Q000378:metabolism / Q000472:pathogenicity*; D011991:Receptors, Virus / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen; D007128:Immunoglobulin Fragments; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; C070506:ecotropic murine leukemia virus receptor