Spin trapping of superoxide in the presence of beta-cyclodextrins.
The trapping of superoxide anion with DMPO and DEPMPO has been carried out in the presence of a methylated beta-cyclodextrin, Me-beta-CD; inclusion of the spin adducts in the cavity of Me-beta-CD resulted in a seven-fold increase of their half-life (t1/2 = 96 min for DEPMPO-superoxide spin adduct) and in their protection towards glutathione peroxidase (Gpx) and also ascrobate anion in the case of DEPMPO.
Karoui
Hakim
H
UMR 6517 CNRS and Universités d'Aix-Marseille 1 and 3, Faculté des Sciences de Saint Jérôme, 13397 Marseille, France. hakim@srepir1.univ-mrs.fr
Rockenbauer
Antal
A
Pietri
Sylvie
S
Tordo
Paul
P
D003505:Cyclodextrins / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D013113:Spin Labels; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D013113:Spin Labels; D047392:beta-Cyclodextrins; D013481:Superoxides; C031215:betadex