Novel chiral gallium Lewis acid catalysts with semi-crown ligands for aqueous asymmetric Mukaiyama aldol reactions.
Asymmetric Mukaiyama aldol reactions in aqueous media (water-ethanol = 9:1) were catalyzed by chiral gallium catalysts with semi-crown ligands to give aldol products with good yields, syn-diastereoselectivities and enantioselectivities.
Li
Hui-Jing
HJ
Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P.R. China.
Tian
Hong-Yu
HY
Chen
Yong-Jun
YJ
Wang
Dong
D
Li
Chao-Jun
CJ