title: Quantification of renal perfusion using an intravascular contrast agent (part 1): results in a canine model.
abstract: In this work absolute values of regional renal blood volume (rRBV) and flow (rRBF) are assessed by means of contrast-enhanced (CE) MRI using an intravascular superparamagnetic contrast agent. In an animal study, eight foxhounds underwent dynamic susceptibility-weighted MRI upon injection of contrast agent. Using principles of indicator dilution theory and deconvolution analysis, parametric images of rRBV, rRBF, and mean transit time (MTT) were computed. For comparison, whole-organ blood flow was determined invasively by means of an implanted flow probe, and the weight of the kidneys was evaluated postmortem. A mean rBV value of 28 ml/100 g was found in the renal cortex, with a corresponding mean rBF value of 524 ml/100 g/min and an average MTT of about 3.4 s. Although there was a systematic difference between the absolute blood flow values determined by MRI and the ultrasonic probe, a significant correlation (r(s) = 0.72, P < 0.05) was established. The influence of the arterial input function (AIF), T(1) relaxation effects, and repeated measurements on the precision of the perfusion quantitation is discussed.
authors.affiliation: Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Aumann
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.forename: Armin
authors.initials: A
authors.lastname: Just
authors.forename: Karen
authors.initials: K
authors.lastname: Briley-Saebo
authors.forename: Atle
authors.initials: A
authors.lastname: Bjørnerud
authors.forename: Michael
authors.initials: M
authors.lastname: Bock
authors.forename: Gunnar
authors.initials: G
authors.lastname: Brix
mesh_terms: D000818:Animals; D001810:Blood Volume; D003287:Contrast Media / Q000008:administration & dosage*; D003911:Dextrans; D004285:Dogs; D052203:Ferrosoferric Oxide; D007091:Image Processing, Computer-Assisted; D007262:Infusions, Intravenous; D007501:Iron / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D010087:Oxides / Q000008:administration & dosage; D012079:Renal Circulation
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide