[Expression of TNF alpha and VCAM-1 in nasal polyps and relation with eosinophil infiltration].
OBJECTIVE
To study the expression of TNF alpha and VCAM-1 in nasal polyps tissue and its significance.


METHODS
Paraffin sections of nasal polyps and chronic rhinitis samples were studied with immunohistochemical technique.


RESULTS
Expression of TNF alpha and VCAM-1 were stranger in nasal polyps tissues than in controls. There was positive relationship between the expression of TNF alpha and that of VCAM-1(r = 0.833), and expression of VCAM-1 coincide with eosinophil infiltration(r = 0.746).


CONCLUSIONS
It is suggested that TNF alpha may up-regulate the expression of VCAM-1 in vessel endothelium, and prompt adhesion and migration of eosinophils, TNF alpha and VCAM-1 may play important role in the pathogenesis of nasal polyps.
Wang
C
C
Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital, Bethune Faculty of Medical Sciences, Jilin University, Changchun 130031.
Dong
Z
Z
Guan
G
G
Yang
Z
Z
D000328:Adult; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1