[The preparation of collagen burn pellicle of compound sulfadiazine silver and assessment of its efficacy in an animal experiment on deep partial thickness burn wound].
OBJECTIVE
To prepare the collagen burn pellicle of compound sulfadiazine sliver and observe its therapeutic effect on deep partial thickness burn wound.


METHODS
The initator method was adopted for preparing the collagen burn pellicle of compound sulfadiazine sliver. A model of deep partial thickness burn wound was established in 84 SD rats for the observation of the effect of collagen burn pellicle of compound sulfadiazine sliver on burn wound healing.


RESULTS
The collagen burn pellicle of compound sulfadiazine sliver enhanced the coming off of necrotic tissues and the healing of burn wound. The hydroxyproline content of burn wound was higher in the experiment group than that in the comparison groups, (P < 0.05). The percentage of G0/G1-phase in full skin cells of burn wound at 5, 7, 10 and 14 days after burn was lower than that in the comparison groups (P < 0.05). The percentage of S-phase at 5, 7 and 14 days was higher in the experiment group than that in the comparison groups (P < 0.05). The water content in full skin cells of burn wound at 24, 36 and 48 hours after burn was significantly lower in the experiment group than that the comparison groups (P < 0.05).


CONCLUSIONS
The collagen burn pellicle of compound sulfadiazine sliver can enhance wound healing in the management of deep partial thickness burn wound.
La
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Department of Pharmacy, Nan Fang Hospital, Frist Military Medical University, Guangzhou 510515, China.
Jiang
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Huo
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D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D003094:Collagen / Q000627:therapeutic use*; D004338:Drug Combinations; D008567:Membranes, Artificial; D011897:Random Allocation; D051381:Rats; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D008567:Membranes, Artificial; D003094:Collagen; D012837:Silver Sulfadiazine