Alpha2-adrenoceptor antagonist SL 84.0418 reduces the expression of neocortical spike-and-wave spindling episodes in DBA/2J mice.
The present work was undertaken to study the effects of alpha(2)-adrenoceptor antagonist 2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3,2,1-hi]-indole hydrochloride (SL 84.0418) on the neocortical spike-and-wave spindling episodes (S and W) in the cortical electroencephalogram (ECoG) of DBA/2J mice. Our data indicate that SL 84.0418 (0.1-1.0-10 mg/kg ip) dose-dependently reduces the S and W of DBA/2J mice. This effect appears 30 min after drug administration and lasts for the duration of the recording period (240 min). The reducing effect of the SL 84.0418 on the S and W of mice was comparable to that induced by tolazoline (10-20-40 mg/kg ip), a well-known alpha(2)-adrenoceptor antagonist, whereas the alpha(2)-adrenoceptor agonist clonidine (0.02-0.1-0.5 mg/kg ip) significantly increased it. The present results indicate that SL 84.0418 administration induces significant reduction on S and W of DBA/2J mice suggesting a possible involvement of noradrenergic system in the development of S and W of DBA/2J mice.
Capasso
Anna
A
Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy. annacap@unisa.it
Loizzo
Alberto
A
D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D019579:Neocortex / Q000187:drug effects* / Q000502:physiology*; D011758:Pyrroles / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology
D007211:Indoles; D011758:Pyrroles; D011942:Receptors, Adrenergic, alpha; C074936:SL 84.0418