The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation.
BACKGROUND
Solanum melongena L. (Solanaceae) has antioxidant, analgesic, hypolipidemic and antiallergic activity.


METHODS
The anti-inflammatory effects of the water extract of the S. melongena (SMWE) were investigated in PAR2-mediated mouse paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw of mice. The SMWE (1, 5, 10, and 100 mg/kg) was orally administered 1 h before induction of inflammation.


RESULTS
At doses of 5, 10, and 100 mg/kg, the SMWE showed significant inhibition of both paw edema and vascular permeability. The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue.


CONCLUSIONS
These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema.
Han
Seung-Woo
SW
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea.
Tae
Jin
J
Kim
Jin-A
JA
Kim
Dae-Ki
DK
Seo
Geom-Seog
GS
Yun
Ki-Jung
KJ
Choi
Suck-Chei
SC
Kim
Tae-Hyun
TH
Nah
Yong-Ho
YH
Lee
Young-Mi
YM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004487:Edema / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009842:Oligopeptides / Q000494:pharmacology; D009195:Peroxidase / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000494:pharmacology*; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000819:agonists*; D032323:Solanum melongena; D014357:Trypsin / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009842:Oligopeptides; D010936:Plant Extracts; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; D014409:Tumor Necrosis Factor-alpha; C113425:cinnamoyl-LIGRLO-amide; D009195:Peroxidase; D014357:Trypsin