Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological response profile. Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor.
Abbracchio
Maria P
MP
Department of Pharmacological Sciences, University of Milan, Italy.
Boeynaems
Jean-Marie
JM
Barnard
Eric A
EA
Boyer
José L
JL
Kennedy
Charles
C
Miras-Portugal
Maria Teresa
MT
King
Brian F
BF
Gachet
Christian
C
Jacobson
Kenneth A
KA
Weisman
Gary A
GA
Burnstock
Geoffrey
G
D000818:Animals; D001665:Binding Sites / Q000502:physiology; D006801:Humans; D043562:Receptors, G-Protein-Coupled; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D058470:Receptors, Purinergic P2Y; D014532:Uridine Diphosphate Glucose / Q000378:metabolism*
D043562:Receptors, G-Protein-Coupled; D018048:Receptors, Purinergic P2; D058470:Receptors, Purinergic P2Y; D014532:Uridine Diphosphate Glucose; C518528:P2Y14 receptor, human