title: Convenient synthesis of fluorinated nucleosides with perfluoroalkanesulfonyl fluorides.
abstract: Perfluoroalkanesulfonyl fluorides are effective dehydroxy-fluorination agents for the hydroxyl group at the sugar moiety of nucleoside derivatives and give the corresponding fluorinated nucleosides in good yield with an inversion of configuration in a single step.
authors.affiliation: AminoScience Laboratories, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan. satoshi_takamatsu@ajinomoto.com
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Katayama
authors.forename: Naoko
authors.initials: N
authors.lastname: Hirose
authors.forename: Etienne
authors.initials: E
authors.lastname: De Cock
authors.forename: Geert
authors.initials: G
authors.lastname: Schelkens
authors.forename: Marc
authors.initials: M
authors.lastname: Demillequand
authors.forename: Jozef
authors.initials: J
authors.lastname: Brepoels
authors.forename: Kunisuke
authors.initials: K
authors.lastname: Izawa
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005461:Fluorine / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D013441:Sulfinic Acids; D005461:Fluorine; C048899:sulfuryl fluoride