Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene.
[reaction: see text] The regioselective palladium(0)-catalyzed arylation of 3-furoate and 3-thiophenecarboxylate esters with aryl bromides is described. Conditions were developed that allow for the selective synthesis of either 2-aryl or 5-aryl products.
Glover
Bobby
B
GlaxoSmithKline, Chemical Development, Five Moore Drive, P O Box 13398, Research Triangle Park, North Carolina 27709, USA.
Harvey
Kimberly A
KA
Liu
Bing
B
Sharp
Matthew J
MJ
Tymoschenko
Maria F
MF
D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*
D005663:Furans; D013876:Thiophenes; D010165:Palladium