title: Individualizing salvage regimens: the inhibitory quotient (Ctrough/IC50) as predictor of virological response.
abstract: Increased drug levels could overcome resistance and improve the response to a salvage regimen. We evaluate the inhibitory quotient (IQ, Ctrough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens. The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1. The IQ could be useful to improve the virological response to a dual PI salvage regimen.
authors.affiliation: Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Casado
authors.forename: Ana
authors.initials: A
authors.lastname: Moreno
authors.forename: Raquel
authors.initials: R
authors.lastname: Sabido
authors.forename: Paloma
authors.initials: P
authors.lastname: Martí-Belda
authors.forename: Antonio
authors.initials: A
authors.lastname: Antela
authors.forename: Fernando
authors.initials: F
authors.lastname: Dronda
authors.forename: María J
authors.initials: MJ
authors.lastname: Perez-Elías
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
mesh_terms: D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000097:blood* / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D016879:Salvage Therapy
chemical_list: D017320:HIV Protease Inhibitors