title: Studies of strontium biokinetics in humans. Part 2: uptake of strontium from aqueous solutions and labelled foodstuffs.
abstract: The accidental release of radioactive isotopes of strontium, mainly (90)Sr, into the environment and its transfer into the biosphere results in an internal radiation exposure of the affected population. In order to obtain reliable estimates of the committed dose due to an intake of Sr radionuclides, reliable information on its metabolic behaviour inside the human body is needed, i.e. biokinetic data on fractional uptake from contaminated foodstuffs, distribution to and retention in different organs and tissues of the human body. Such information can be obtained by tracer kinetic investigations. The committed effective dose is dependent on the fractional intestinal absorption of the ingested activity (f(1) value). The International Commission on Radiological Protection in its publication ICRP 67 adopted an f(1) value of 0.3 for adults. This study is aimed at investigating if the value corresponds with the actual uptake from contaminated foodstuffs. Aqueous solutions and contaminated vegetables, i.e. cress and salad (lettuce) were used as test materials. For this purpose, the methodology for intrinsic labelling of foodstuffs described in part 1 was applied. For aqueous solutions, a mean f(1) value of 0.63+/-0.14 (mean +/- SD) was obtained by administering 1 mg of strontium. The uptake of Sr from cress intrinsically labelled with about 1 mg Sr almost corresponds to that from aqueous solutions (f(1)=0.62+/-0.10), but from lettuce it is reduced by a factor of 2 (f(1)=0.27+/-0.08).
authors.affiliation: Institute of Radiation Protection, GSF National Research Center for Environment and Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany. vera.hoellriegl@gsf.de
authors.forename: Vera
authors.initials: V
authors.lastname: Höllriegl
authors.forename: Pascale
authors.initials: P
authors.lastname: Louvat
authors.forename: Eckhard
authors.initials: E
authors.lastname: Werner
authors.forename: Paul
authors.initials: P
authors.lastname: Roth
authors.forename: Peter
authors.initials: P
authors.lastname: Schramel
authors.forename: Iris
authors.initials: I
authors.lastname: Wendler
authors.forename: Norbert
authors.initials: N
authors.lastname: Felgenhauer
authors.forename: Thomas
authors.initials: T
authors.lastname: Zilker
mesh_terms: D000328:Adult; D005260:Female; D005502:Food; D005507:Food Contamination, Radioactive; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011829:Radiation Dosage; D013326:Strontium Radioisotopes / Q000493:pharmacokinetics*; D014867:Water
chemical_list: D013326:Strontium Radioisotopes; D014867:Water