[The effect of salvia miltiorrhiza and shengmai on inflammatory mediator and renal function of post-operative patients with obstructive jaundice].
OBJECTIVE
To investigate the effect of salvia miltiorrhiza and shengmai (SS) on inflammatory mediator and renal function in patients with obstructive jaundice (OJ).


METHODS
This study included three groups: the OJ patients receiving SS for 6 days after operation (the SS group, n = 15); the OJ patients not receiving SS (the OJ group, n = 15); the patients with other hepato-biliary disorders (the Non-OJ group, n = 15). The levels of ET, LPs, TNF-alpha, IL-6, IL-8 and urine RBP, TFR, ALB were measured one day before operation and 1, 4, 7 days after operation.


RESULTS
The SS group's LPs, TNF-alpha, IL-6, IL-8, ET, RBP, TFR and ALB levels were obviously lower on Day 7 after operation as compared with those on Day 1 after operation (P < 0.05). The urine RBP and ALB levels were significantly lower in the SS group than in the OJ group (P < 0.05).


CONCLUSIONS
The post-operative use of salvia miltiorrhiza and shengmai for patients with obstructive jaundice may effectively decrease the postoperative levels of plasma LPs, ET, TNF-alpha, IL-6 and IL-8. At the same time, salvia miltiorrhiza and shengmai may protect renal function by inhibiting inflammatory mediator and improving blood dynamics.
Peng
B
B
Department of Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Du
J
J
Jia
Q
Q
Qiao
A
A
Wu
Y
Y
Liu
X
X
Qiang
Q
Q
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004731:Endotoxins / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts; D027561:Salvia miltiorrhiza; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D015850:Interleukin-6; D016209:Interleukin-8; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination