Comparison of methods of interpretation of checkerboard synergy testing.
Four different methods for interpreting the results of checkerboard synergy testing were compared by applying each to a set of synergy study data. Statistically significant differences in synergy were detected among methods (% synergy ranged from 10 to 83%). As interpretations were found to vary widely based upon method, one should be aware of this in interpreting the relevant literature.
Bonapace
Charles R
CR
Anti-Infective Research Laboratory, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA.
Bosso
John A
JA
Friedrich
Lawrence V
LV
White
Roger L
RL
D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000900:Anti-Bacterial Agents