[Effect of the Purariae-isofiavones on atrophic nasal mucosas in ovariectomized rats].
OBJECTIVE
To study the effect of Purariae-isoflavone on atrophic nasal mucosas in ovariectomized rats.


METHODS
60 rats were divided into four groups randomly, every group with 15 rats. The first group was studied as normal control group. Rats of the second group were ovariectomized and not given any treatment. Rats of the third group were given Weinian by gastrogavage from 30 days after being ovariectomized to being killed. Rats of the forth group were given purariae isoflavone by gastrogavage from 30 days after operation to being killed. Level of Estrodiol (E2) of every rat was measured. Morphological changes of the nasal mucosas were observed by light-microscopy and electron-microscopy.


RESULTS
30 days after being ovariectomized, atrophic nasal mucosas occured, and average E2 level was lower significantly than that of control group (P < 0.05). Atrophic mucosas recovered after being treated with Weinian or Purariae isoflavone. E2 level of the third group was lower significantly than that of the first group and the second group (P < 0.05). E2 level of the forth group recovered (P > 0.05).


CONCLUSIONS
Purariae-isoflavone have effects on treating the atrophic nasal mucosas and recovering E2 level in ovariectomized rats.
Qi
B
B
Department of Otolaryngology, Second Affiliated Hospital of Kunming Medical College, Kunming 650031.
Wang
Z
Z
Zheng
M
M
Wu
P
P
D000818:Animals; D001284:Atrophy / Q000188:drug therapy; D015914:Estrogen Replacement Therapy; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000627:therapeutic use*; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology*; D010052:Ovariectomy; D029908:Pueraria / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007529:Isoflavones