title: [Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population].
abstract: OBJECTIVE
  To study the Mitochondrial DNA 7445A-->G mutation in nonsyndromic deafness patients in Chinese population.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to screen the mitochondrial DNA 7445A-->G mutation among 128 nonsyndromic deafness individuals from 32 pedigrees, 135 sporadic nonsyndromic deafness patients and 100 normal subjects.
  
  
  RESULTS
  The 7445A-->G mutation did not appear in the experiment.
  
  
  CONCLUSIONS
  Incidence of the mitochondrial 7445A-->G mutation was lower than that of mtDNA 1555A-->G mutation in nonsyndromic deafness patients in China.
authors.affiliation: First Hospital, Beijing Medical University, Beijing 100034.
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
authors.forename: X M
authors.initials: XM
authors.lastname: Ke
authors.forename: Y
authors.initials: Y
authors.lastname: Qi
authors.forename: H B
authors.initials: HB
authors.lastname: Xu
authors.forename: Z P
authors.initials: ZP
authors.lastname: Gu
authors.forename: X C
authors.initials: XC
authors.lastname: Liu
authors.forename: J F
authors.initials: JF
authors.lastname: Liu
mesh_terms: D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D004272:DNA, Mitochondrial