title: Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides.
abstract: Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion.
authors.affiliation: Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Meng
authors.forename: Meng-Shen
authors.initials: MS
authors.lastname: Cai
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
authors.forename: Rou-Li
authors.initials: RL
authors.lastname: Zhou
authors.forename: Ta-Lin
authors.initials: TL
authors.lastname: Suo
mesh_terms: D000606:Amino Sugars / Q000138:chemical synthesis* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D006031:Glycosylation; D006801:Humans; D007797:Laminin; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D014407:Tumor Cells, Cultured
chemical_list: D000606:Amino Sugars; D007797:Laminin; C000458:N-acetyllactosamine