Genetic basis of antibiotic resistance in Streptococcus agalactiae strains isolated in a French hospital.
The genetic basis of antibiotic resistance in 113 unrelated group B streptococci was studied by PCR. Ninety-four strains were resistant to tetracycline-minocycline, and tet(M) was detected in 85% of these isolates. Seventeen erythromycin-resistant strains contained the erm(B), erm(TR), or mef(A) gene. Eleven strains exhibited high-level resistance to kanamycin due to the presence of the aphA3 gene; eight of these strains were also highly resistant to streptomycin; aad-6-related sequences were detected in seven strains.
Poyart
Claire
C
Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15, France. poyart@necker.fr
Jardy
Laurence
L
Quesne
Gilles
G
Berche
Patrick
P
Trieu-Cuot
Patrick
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005602:France; D006801:Humans; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D013292:Streptococcus agalactiae / Q000235:genetics* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents