title: [Tissue reaction and degradation of super-high molecular weight poly D, L-lactic acid mini-plates and screws: an animal experiment].
abstract: OBJECTIVE
  To investigate the tissue reaction and degradation processes of the super-high molecular weight(Mv = 6.0 x 10(5) kD) poly D, L-lactic acid(PDLLA) mini-plates and screws through the internal fixation for zygomatic arch fracture.
  
  
  METHODS
  It was carried out by the self-contrast study method and comparing with the titanium mini-plates and screws.
  
  
  RESULTS
  There was no side-effects on bone healing. The reaction of soft and hard tissues to PDLLA mini-plates and screws was similar to that of the titanium mini-plates and screws. No complication had been seen with the use of PDLLA mini-plates and screws, including infection, foreign body reaction and underlying osteolysis. The PDLLA devices had no changes in shape after 3 months, and then became the grains in different sizes after 6 months, and were completely resorbed within 12 months in vivo.
  
  
  CONCLUSIONS
  The super-high molecular weight PDLLA mini-plates and screws has good biocompatibility and proper degradation time. It is safe and effective to use the mini-plates and screws made of the super-high molecular weight PDLLA for internal fixation of bone.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: S
authors.initials: S
authors.lastname: Wei
authors.forename: Q
authors.initials: Q
authors.lastname: Zheng
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Xiong
authors.forename: X
authors.initials: X
authors.lastname: Deng
authors.forename: F
authors.initials: F
authors.lastname: Luo
authors.forename: C
authors.initials: C
authors.lastname: Luo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001860:Bone Plates; D001863:Bone Screws; D004285:Dogs; D005593:Fracture Fixation, Internal / Q000295:instrumentation; D011091:Polyesters / Q000378:metabolism*; D015051:Zygomatic Fractures / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)