[Study on the expression of fibronectin after cerebral contusion in rats for timing of injuries].
An experimental model of reproducible focal cerebral contusions in rats was made by a free-drop impacting right hemisphere. The expression of fibronectin and its mRNA after cerebral contusion were detected respectively by immunohistochemical staining and in situ hybridization. Results indicated that the expression of fibronectin and its mRNA increased after injury, and there existed a relationship between increased fibronectin and its mRNA and different intervals after brain injury. It is inferred that the expression of fibronectin and its mRNA can be used for timing of brain injuries and distinguishing antemortem and postmortem brain contusions.
Chen
L
L
Department of Forensic Medicine, Medical Center of Fudan University, Shanghai 200032.
Chen
Y J
YJ
Liu
N G
NG
Li
Z
Z
Zhao
Z Q
ZQ
Gu
Y J
YJ
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D005353:Fibronectins / Q000096:biosynthesis*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D011180:Postmortem Changes; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D005353:Fibronectins; D012333:RNA, Messenger