In vivo and in vitro MR spectroscopic profile of central neurocytomas.
This study reports in vivo and in vitro magnetic resonance spectroscopic findings in two cases of central neurocytomas (CNC) confirmed by immunohistochemistry. Volume localized in vivo proton magnetic resonance spectroscopy (MRS) was carried out before surgery using a point resolved spectroscopy (PRESS) sequence with a repetition time of six seconds and an echo time of 135 msec. Normal spectrum was obtained from gray matter from a volunteer for comparison. (1)H and (31)P in vitro MRS studies were carried out at 9.4 T on the extracts prepared from the surgically excised tumors. The in vivo spectra showed prominent glycine (Gly) and choline (Cho) and low N-acetyl aspartate compared to the normal. The Gly peak was assigned using the in vitro studies. These studies showed that the major contribution to the Cho peak observed in vivo is from phosphocholine. A combination of the presence of NAA and an increased Gly in the proton MR spectrum could be a characteristic feature of CNCs, which are rare intraventricular tumors of neuronal origin.
Jayasundar
Rama
R
Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, 110 029 New Delhi, India. ramajayasundar@hotmail.com
Shah
Tariq
T
Vaishya
Sandeep
S
Singh
Virender P
VP
Sarkar
Chitra
C
D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis*; D002552:Cerebral Ventricles / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018306:Neurocytoma / Q000175:diagnosis*