title: [Distribution of IL-1 beta in periodontium of experimental osteoporosis rats during orthodontic tooth movement].
abstract: OBJECTIVE
  The purpose of this research is to study the expression change of IL-1 beta induced by forces in the periodontium of osteoporosis rats.
  
  
  METHODS
  Eighteen SD rats were randomly divided into three groups: the normal controlled, the normal orthodontically controlled and the experimental group of osteoporosis. Six weeks after ovariectomy, the first molars were moved mesially by 50 g force created from elastic-thread for one week in the force loading groups. Then the rats were killed, and the 5 microns-thick mesiodistal sections of maxillary teeth, including the roots and periodontium were made. IL-1 beta were localized immunohistochemically in periodontium, and semiquantitative analysis of cellular-staining intensity was done by microphotometry.
  
  
  RESULTS
  The IL-1 beta of periodontal ligament cells without loading force were mildly stained in the controlled group, but the staining intensity increased significantly in the periodontium of orthodontically moved teeth, and it showed more strengthened staining in the periodontium of force-loading teeth in osteoporosis rats.
  
  
  CONCLUSIONS
  The results demonstrate that periodontal ligament cells respond to mechanical force by increased production of IL-1 beta, and this can be enhanced by osteoporosis. IL-1 beta is an important cytokine in the process of orthodontically periodontal remodeling.
authors.affiliation: Department of Orthodontics, Stomatological College, Fourth Military Medical University.
authors.forename: M
authors.initials: M
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Zhou
mesh_terms: D000818:Animals; D004967:Estrogens / Q000502:physiology; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis*; D010024:Osteoporosis / Q000378:metabolism*; D010519:Periodontium / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014087:Tooth Movement Techniques
chemical_list: D004967:Estrogens; D007375:Interleukin-1