Hepatoprotective activity of 1-ethoxysilatrane and 1-isopropoxygermatrane.
1-Ethoxysilatrane and 1-isopropoxygermatrane stimulated liver regeneration via activation of some components of the protein-synthesizing complex, in particular, aminoacyl-tRNA synthetases. Acylating activity of aminoacyl-tRNA synthetases increased. Possible mechanisms of these changes are discussed.
Voronkov
M G
MG
Abu Ali ibn Sina Tajik State Medical University, Dushanbe.
Nurbekov
M K
MK
Rasulov
M M
MM
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D005857:Germanium / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009570:Nitriles / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D017646:Organosilicon Compounds / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats; D013379:Substrate Specificity
D019086:Bridged Bicyclo Compounds, Heterocyclic; D009570:Nitriles; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D005857:Germanium; C042292:1-ethoxysilatrane; C060353:isopropoxygermatrane; D000604:Amino Acyl-tRNA Synthetases