[Study on chemosensitivity assay in vitro in the peripheral blood lymphocyte and the tumor cells].
In this study, the MTT method was used to test the sensitivity of the peripheral blood lymphocyte and the tumor cells of 35 patients with neuroglioma to 15 kinds of anti-cancer drugs. The results showed that the peripheral blood lymphocyte and the tumor cells were more sensitive to chemotherapeutic drugs Vm26 and TAX, and sensitive to DDP, Me-CCNU, EADM, ADM, MMC, HCPT, but not sensitive to MTX, ACR, VP-16, VCR and BLM. There were no statistical differences in the rate of sensitivity to the above-mentioned drugs between the peripheral blood lymphocyte and the tumor cells. These results prompt that the chemosensitivity test of the peripheral blood lymphocyte may take the place of the tumor cells for reference to choosing chemotherapeutic drugs in clinical practice.
Yuan
S
S
Institute of Cancer Research, First Affiliated Hospital, WCUMC, Chengdu 610041.
Wang
Y
Y
Jiang
S
S
Yang
Y
Y
Song
Y
Y
Chen
X
X
Tu
C
C
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005910:Glioma / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D016685:Mitomycin / Q000008:administration & dosage; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D016685:Mitomycin; D014750:Vincristine; D004317:Doxorubicin