[Progress in the controlled release systems of hirudin].
Hirudin is very effective in treating and preventing cardiovascular disorders. In this review several polymeric controlled release systems of hirudin are introduced. The advantages of the local delivery for restenosis and the feasibility of endovascular drug-containing pharmaceutic stents for local therapy of cardiovascular thrombosis are discussed.
Li
T
T
Dept of Appl Chem, Sichuan Union University, Chengdu 610065.
Wan
C
C
Li
Y
Y
D003328:Coronary Thrombosis / Q000517:prevention & control*; D016503:Drug Delivery Systems; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D024764:Hirudin Therapy; D006629:Hirudins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D015607:Stents
D005343:Fibrinolytic Agents; D006629:Hirudins