title: Epidemic Rift Valley fever in Saudi Arabia: a clinical study of severe illness in humans.
abstract: We describe the clinical patterns and case-fatality rate associated with severe Rift Valley fever (RVF) in patients who were admitted to the Gizan regional referral hospital during an outbreak of RVF in Saudi Arabia from September through November 2000. A total of 165 consecutive patients (136 men and 29 women) were prospectively studied; all were identified according to a strict case definition, were confirmed to have RVF by serologic testing, and were treated according to a predetermined protocol. The major clinical characteristics of RVF included a high frequency of hepatocellular failure in 124 patients (75.2%), acute renal failure in 68 patients (41.2%), and hemorrhagic manifestations in 32 patients (19.4%). Sixteen patients had retinitis and 7 patients had meningoencephalitis as late complications in the course of the disease. A total of 56 patients (33.9%) died. Hepatorenal failure, shock, and severe anemia were major factors associated with patient death.
authors.affiliation: Department of Medicine, King Fahd Central Hospital, Gizan, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Hazmi
authors.forename: Ephraim Ayobanji
authors.initials: EA
authors.lastname: Ayoola
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abdurahman
authors.forename: Subodh
authors.initials: S
authors.lastname: Banzal
authors.forename: Jammal
authors.initials: J
authors.lastname: Ashraf
authors.forename: Adil
authors.initials: A
authors.lastname: El-Bushra
authors.forename: Ali
authors.initials: A
authors.lastname: Hazmi
authors.forename: Mohammed
authors.initials: M
authors.lastname: Abdullah
authors.forename: Hamid
authors.initials: H
authors.lastname: Abbo
authors.forename: Abdulhadi
authors.initials: A
authors.lastname: Elamin
authors.forename: El-Tayeb
authors.initials: el-T
authors.lastname: Al-Sammani
authors.forename: Mohammed
authors.initials: M
authors.lastname: Gadour
authors.forename: Chandra
authors.initials: C
authors.lastname: Menon
authors.forename: Mirghani
authors.initials: M
authors.lastname: Hamza
authors.forename: Inam
authors.initials: I
authors.lastname: Rahim
authors.forename: Magdy
authors.initials: M
authors.lastname: Hafez
authors.forename: Manish
authors.initials: M
authors.lastname: Jambavalikar
authors.forename: Haider
authors.initials: H
authors.lastname: Arishi
authors.forename: Ali
authors.initials: A
authors.lastname: Aqeel
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D004660:Encephalitis / Q000209:etiology; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D017093:Liver Failure / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009026:Mortality; D012173:Retinitis / Q000209:etiology; D012295:Rift Valley Fever / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D012529:Saudi Arabia / Q000453:epidemiology; D012769:Shock / Q000209:etiology