[The correlation of serum levels of insulin-like growth factors and intrauterine growth: report of a study in rats].
This animal experiment was designed to investigate the relationship of the serum insulin-like growth factors (IGFs) with fetal intrauterine growth. The serum concentrations of IGF-I, -II in 21 fetal rats were measuerd and their relationships with fetal birth weight, length and tissue weights of brain, lung, liver were analysed respecively. The results showed that both of the serum concentrations of IGF-I, -II were positively correlated (P < 0.01) with fetal birth weight, length and tissue weights of brain, lung, liver respectively. These data suggest that both IGF-I and IGF-II may play an important role in fetal intrauterin growth and their decreased concentrations in serum may be factors contributing to fetal intrauterine growth retardation.
Bai
B
B
Department of Pediatrics, Second Affiliated Hospital, WCUMS, Chengdu, 610041.
Li
W
W
Yao
Y
Y
Zeng
Y
Y
Yang
F
F
Xiong
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II