title: [Prostate-specific antigen and its related parameters in detecting prostate cancer].
abstract: Prostate-specific antigen (PSA) is the most useful tumor marker available today. However, its inability to clearly distinguish between prostate cancer and benign prostatic hyperplasia may result in serial and unnecessary prostate biopsies. Various attempts have been made to improve its specificity. PSA-related parameters including PSA density, PSA density for the transition zone, age- or race-specific PSA reference range, PSA velocity, and percent free PSA are the most promising approaches available at present.
authors.affiliation: Dept. of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kuruma
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D011933:Reagent Kits, Diagnostic; D017430:Prostate-Specific Antigen