title: Off-pump coronary artery bypass surgery does not reduce gastrointestinal complications.
abstract: OBJECTIVE
  Gastrointestinal (GI) complications following on-pump coronary artery bypass grafting (CABG) are rare, but carry a high mortality rate. Prolonged cardiopulmonary bypass (CPB) has been associated with a higher incidence of such complications. Little is known about the effect of avoiding CPB on GI complications. Our hypothesis was that off-pump CABG might reduce such complications.
  
  
  METHODS
  A total of 2327 consecutive cases undergoing isolated CABG between April 1997 and May 2001 were identified from four consultants' practice at the two cardiothoracic centres involved in this study. We performed a multivariable logistic regression analysis to identify the risk factors for development of post-operative GI complications. Potential risk factors considered in the logistic model were age, sex, angina, ejection fraction, peripheral vascular disease, renal dysfunction, redo operations, previous GI complications, priority of surgery and the use of CPB.
  
  
  RESULTS
  A total of 1210 cases were performed on CPB, compared to 1117 off-pump. The incidence of GI complications was 1.2% (n = 14) in the on-pump group and 1.6% (n = 18) in the off-pump group (P = 0.347). The incidence of in-hospital mortality, in the patients who had a GI complication, was 28.6% (n = 4) and 22.2% (n = 4), respectively (P = 0.681). The results of the logistic regression analysis showed that renal dysfunction, advancing age and previous history of GI surgery are significant risk factors for GI complications after coronary bypass surgery whether CPB is used or not.
  
  
  CONCLUSIONS
  Our study suggests that off-pump and on-pump techniques are similar in the rates of GI complications. We suggest that a properly designed randomized control trial is needed to verify our findings.
authors.affiliation: Department of Cardiothoracic Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Musleh
authors.forename: Nirav C
authors.initials: NC
authors.lastname: Patel
authors.forename: Antony D
authors.initials: AD
authors.lastname: Grayson
authors.forename: D Mark
authors.initials: DM
authors.lastname: Pullan
authors.forename: Daniel J M
authors.initials: DJ
authors.lastname: Keenan
authors.forename: Brian M
authors.initials: BM
authors.lastname: Fabri
authors.forename: Ragheb
authors.initials: R
authors.lastname: Hasan
mesh_terms: D000367:Age Factors; D000368:Aged; D017091:Colitis, Ischemic / Q000209:etiology; D003108:Colonic Diseases / Q000209:etiology; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D003327:Coronary Disease / Q000601:surgery*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors