title: Alleviation of pre-exposure to low-dose 16O8+ ion on mouse testicular histological damage induced by subsequent high-dose irradiation.
abstract: The testes of the B6C3F1 hybrid strain mice were irradiated with 0.05 Gy of 16O8+ ion as the pre-exposure dose (D1), and were then irradiated with 2 Gy of 16O8+ ion as challenging radiation dose (D2) at 4 h after per-exposure. Testicular morphology was observed by light microscope at 35th day after radiation. The results showed that irradiation of mouse testes with 2 Gy of 16O8+ ion significantly impaired, mainly reduction of tubule diameter and decrease or loss of germ cells in various developing stages, especially spermatogenic elements. Pre-exposure to a low-dose (0.05 Gy) of 16O8+ ion significantly alleviated above mentioned damage on testicular morphology induced by subsequent a high-dose (2 Gy) radiation.
authors.affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: R L
authors.initials: RL
authors.lastname: Zheng
authors.forename: Q X
authors.initials: QX
authors.lastname: Gao
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Wei
authors.forename: W J
authors.initials: WJ
authors.lastname: Li
authors.forename: W Q
authors.initials: WQ
authors.lastname: Chen
authors.forename: J P
authors.initials: JP
authors.lastname: Liang
authors.forename: G W
authors.initials: GW
authors.lastname: Han
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.forename: H M
authors.initials: HM
authors.lastname: Xie
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007477:Ions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013737:Testis / Q000473:pathology / Q000528:radiation effects*
chemical_list: D007477:Ions; D010100:Oxygen