Temperament in schizophrenia: a study of the tridimensional personality questionnaire (TPQ).
OBJECTIVE
The aim of this study was to assess dimensions of temperament as defined by Cloninger's neurobiological model using the tridimensional personality questionnaire (TPQ) in a sample of consecutively recruited schizophrenic patients.


METHODS
We used the French version of the TPQ to compare 45 stable, euthymic schizophrenic patients with 126 controls with no personal or familial history of psychiatric disorder. After comparison of TPQ scores between groups, we also performed a multivariate analysis to avoid the confounding effects of age, gender, and alcohol and substance use disorder comorbidity.


RESULTS
Harm avoidance (HA) was higher in schizophrenic patients than in controls.


CONCLUSIONS
This replicates and extends the results of previous studies suggesting that schizophrenic patients have high HA and that HA might be a marker for underlying genetic vulnerability to schizophrenia.
Szöke
Andrei
A
Service de psychiatrie adulte, Hôpital Henri Mondor et Albert Chenevier, 40, rue de Mesly, AP-HP, 94000, Créteil, France.
Schürhoff
Franck
F
Ferhadian
Nathalie
N
Bellivier
Frank
F
Rouillon
Frédéric
F
Leboyer
Marion
M
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010554:Personality Disorders / Q000150:complications* / Q000175:diagnosis*; D010555:Personality Inventory; D012559:Schizophrenia / Q000150:complications*; D012720:Severity of Illness Index; D013694:Temperament