Genetic structure of seven Mexican indigenous populations based on five polymarker loci.
This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas-Guerrero, Nahuas-Xochimilco, and Tzeltales) on the basis of five PCR-based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H(T)) can be attributed to individual variation within populations. Mixteca-Alta, Mixteca-Baja, and Nahuas-Xochimilco show indications of higher admixture with European-derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease-marker associations in the search for candidate genes of complex diseases.
Buentello-Malo
Leonora
L
Instituto de Investigaciónes Antropologicas, Universidad Nacional Autonoma de Mexico, Mexico DF.
Peñaloza-Espinosa
Rosenda I
RI
Loeza
Francisco
F
Salamanca-Gomez
Fabio
F
Cerda-Flores
Ricardo M
RM
D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D005819:Genetic Markers