New multidrug resistance reversal agents.
Multidrug resistance (MDR) to antitumor agents represents a significant challenge to effective chemotherapy. The use of MDR modulators is a promising approach to overcome the undesired MDR phenotype. The more effective MDR modulators are urgently needed for clinical use. This review focuses on literatures published in 1998-2001.
Kawase
Masami
M
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan. kawasema@josai.ac.jp
Motohashi
Noboru
N
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004095:Dihydropyridines / Q000737:chemistry / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010640:Phenothiazines / Q000737:chemistry / Q000494:pharmacology; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology; D011405:Propafenone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology; D014700:Verapamil / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D004095:Dihydropyridines; D005419:Flavonoids; D010640:Phenothiazines; D028321:Plant Preparations; D011804:Quinolines; D011405:Propafenone; D014700:Verapamil