title: Intramedullary spinal cavernous malformation following spinal irradiation. Case report and review of the literature.
abstract: There is a growing body of evidence in the literature suggesting that cavernous malformations of the central nervous system may develop after neuraxis irradiation. The authors discuss the case of a 17-year-old man who presented with progressive back pain and myelopathy 13 years after undergoing craniospinal irradiation for a posterior fossa medulloblastoma. Spinal magnetic resonance (MR) imaging, performed at the time of his initial presentation with a medulloblastoma, demonstrated no evidence of a malformation. Imaging studies and evaluation of cerebrospinal fluid revealed no evidence of recurrence or dissemination. Spinal MR imaging demonstrated an extensive lesion in the thoracic spine with an associated syrinx suggestive of a cavernous malformation. A thoracic laminectomy was performed and the malformation was successfully resected. Pathological examination confirmed the diagnosis. The patient did well after surgery and was ambulating without assistance 6 weeks later. To the best of the authors' knowledge, this is the second reported case in the literature and the first in the young adult age group suggesting the de novo development of cavernous malformations in the spinal cord after radiotherapy. An increased awareness of these lesions and close follow-up examination are recommended in this setting.
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: Prithvi
authors.initials: P
authors.lastname: Narayan
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Barrow
mesh_terms: D000293:Adolescent; D002528:Cerebellar Neoplasms / Q000532:radiotherapy*; D006801:Humans; D015192:Infratentorial Neoplasms / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology