[Effects on the amount of total hemolytic complement levels(CH50) and immunoglobulin in serum induced by the implantation of biomaterials into rats].
Three kinds of biomaterials, PES, YP and SR, were implanted into the subcutaneous tissue of rats and stayed there for 7, 14, 30, 60 and 90 days. Then using the immunity assaying system (Beckman, ICS) and the standard method of measuring the value of total hemolytic complement levels (CH50), we determined the values of immunoglobulin and CH50 in serum of rats. The results showed the amounts of IgG and IgA of rats with the implanted YP and SR materials were significantly higher than those of the control groups, and their value of CH50 was significantly lower than that of the control group. There was no significant difference between the PES group and the control group.
Zhu
M
M
Biomedical Material Test Centre of Sichuan, Chengdu 610041.
Zeng
Y
Y
Jiang
L
L
Huang
P
P
Wu
Z
Z
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D015941:Complement Hemolytic Activity Assay; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008422:Materials Testing; D019919:Prosthesis Implantation; D051381:Rats; D017207:Rats, Sprague-Dawley
D001672:Biocompatible Materials; D007136:Immunoglobulins; D003165:Complement System Proteins