Targeting molecular mechanisms in cancer.
Malignant disease is characterized by the disregulated growth of transformed cells. In recent years, dramatic insight into the molecular mechanisms of this phenomenon have come from basic cancer research. Detailed knowledge of the molecular pathology of cancer allows therapeutic agents to be designed that specifically target aberrant cellular processes. There are currently a number of targeted treatment strategies being evaluated. In the future, it is likely that this mechanistic approach will have a significant impact on clinical oncology and the diagnostic evaluation of tumours.
Balleine
Rosemary L
RL
Department of Translational Oncology, Westmead Hospital, New South Wales, Australia. roseary_balleine@wmi.usyd.edu.au
Kefford
Richard F
RF
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D020411:Oligonucleotide Array Sequence Analysis
D000970:Antineoplastic Agents