[On the mechanisms of cardiac hypertrophy].
Here we reviewed the progress of researches on the mechanism of cardiac hypertrophy and discussed its putative mechanisms. With regard to the heredity and variability of familial hypertrophic cardiomyopathy and mitochondrial cardiomyopathy and other changes, we emphasize that the imbalance between the energy supply and demand of the overloaded pressure determines the occurrence of cardiac hypertrophy. Also we refer to the involving roles of the mechanical stress and some paracrine/autocrine factors in cardiac hypertrophy. Finally we hypothesize that there exists an unknown small molecule being involved in regulating the gene expression and phenotype in cardiac hypertrophy.
Pan
D S
DS
Fuwai Heart Hospital, Chinese Academy of Medical Sciences, Peking Union Medicine College, Beijing 100037.
Tian
C
C
Chen
L Y
LY
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000503:physiopathology; D004734:Energy Metabolism; D006801:Humans