[Synthesis and pharmacological activity of betulin dinicotinate].
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru.
Flekhter
O B
OB
Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054 Russia. obf@anrb.ru
Karachurina
L T
LT
Nigmatullina
L R
LR
Sapozhnikova
T A
TA
Baltina
L A
LA
Zarudiĭ
F S
FS
Galin
F Z
FZ
Spirikhin
L V
LV
Tolstikov
G A
GA
Pliasunova
O A
OA
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D000917:Antibody Formation / Q000187:drug effects; D001168:Arthritis / Q000188:drug therapy; D029662:Betula / Q000737:chemistry; D002056:Burns / Q000188:drug therapy; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use / Q000633:toxicity; D000094062:Betulinic Acid
D000276:Adjuvants, Immunologic; D019380:Anti-HIV Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016655:HIV Core Protein p24; D014315:Triterpenes; C473190:betulin dinicotinate; D000094062:Betulinic Acid; C002503:betulin