Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe.
This paper summarizes quantitative in vivo laminin immunofluorescence analysis of mammary glands and skin epithelial structures from mice exposed to 1 GeV/amu Fe ions. Digital confocal microscopic images were quantified and linked to the rough "core-penumbra" Fe track physical description. Comparison to gamma-ray sparsely ionizing radiation suggested the core of the Fe track being responsible for a biological response only seen with energetic Fe particles. Conclusions for modeling in vivo responses to radiation were then implied.
Costes
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National Cancer Institute, Ft. Detrick, Frederick, MD 21702, USA.
Barcellos-Hoff
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D000818:Animals; D001485:Basement Membrane / Q000528:radiation effects; D001940:Breast / Q000528:radiation effects*; D003359:Cosmic Radiation; D004307:Dose-Response Relationship, Radiation; D004817:Epidermis / Q000528:radiation effects; D004847:Epithelial Cells / Q000528:radiation effects; D004848:Epithelium / Q000528:radiation effects*; D005260:Female; D020450:Heavy Ions / Q000009:adverse effects*; D007501:Iron; D007797:Laminin / Q000528:radiation effects*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D012062:Relative Biological Effectiveness; D012867:Skin / Q000528:radiation effects*
D007797:Laminin; D007501:Iron