Primary small-cell carcinoma of the endometrium: clinicopathological study of a case and review of the literature.
BACKGROUND
Small-cell carcinomas are almost always primary in the lungs and are highly malignant. These tumors may also occur in the female genital tract. However, primary small-cell carcinoma of the endometrium is extremely rare with very few cases reported in the English literature. This tumor may exhibit evidence of neuroendocrine differentiation and has a high propensity for systemic spread and poor prognosis.


METHODS
A 55-year-old postmenopausal woman with primary small-cell carcinoma of the endometrium, FIGO stage Ib, underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and sampling node biopsies of the parametrial spaces, followed by adjuvant combined chemotherapy.


CONCLUSIONS
A case of small-cell carcinoma of the endometrium, is reported and its clinical, histological and immunohistochemical features are discussed.
Varras
M
M
Department of Obstetrics and Gynaecology, G. Chatzikosta-General State Hospital, Ioannina, Greece.
Akrivis
Ch
Ch
Demou
A
A
Hadjopoulos
G
G
Stefanaki
S
S
Antoniou
N
N
D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D014463:Ultrasonography