title: [Synthesis of a new cyclodextrin derivative and its application as CGC chiral stationary phase in determination of enantiomeric excess].
abstract: A new cyclodextrin (CD) derivative, 2,6-di-O-benzyl-3-O-valeryl-beta-CD, was synthesized and characterized by 1H NMR and IR. Using the beta-CD derivative as chiral stationary phase of capillary gas chromatography, one chiral column was prepared. On this column, the enantiomeric excesses (e.e.) of 1-(2,4-dichlorophenyl) ethanol obtained by asymmetric catalytic hydrogenation of 2,4-dichloroacetophone and trans-3-propyloxiranemethanol synthesized by Sharpless epoxidation of trans-2-hexenol were determined and the catalytic reactions were evaluated. The results are satisfactory.
authors.affiliation: College of Applied Chemistry, China Agricultural University, Beijing 100094, China.
authors.forename: Xue-yan
authors.initials: XY
authors.lastname: Shi
authors.forename: Hong-chao
authors.initials: HC
authors.lastname: Guo
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Wen-ge
authors.initials: WG
authors.lastname: Jin
authors.forename: Jing-mei
authors.initials: JM
authors.lastname: Zhou
mesh_terms: D000098:Acetophenones / Q000032:analysis / Q000302:isolation & purification*; D002849:Chromatography, Gas / Q000295:instrumentation* / Q000379:methods; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014631:Valerates / Q000138:chemical synthesis*; D047392:beta-Cyclodextrins
chemical_list: C476554:2,6-di-O-benzyl-3-O-valeryl-beta-cyclodextrin; D000098:Acetophenones; D003505:Cyclodextrins; D014631:Valerates; D047392:beta-Cyclodextrins; C036847:2',4'-dichloroacetophenone