HLA-G and MIC expression in tumors and their role in anti-tumor immunity.
Non-classical MHC class Ib molecules have attracted growing interest in recent years, especially because they interact with non-T-cell inhibitory or triggering receptors expressed on natural killer (NK) and T cells, suggesting that they have a role in immune recognition. Abnormalities in MHC class Ib expression are frequently found in human tumors of various histologies and might be associated with poor clinical outcome despite the local accumulation of immune competent cells. Available data suggest that the balance between activating and suppressing signals significantly influences the efficacy of the immune response and consequently of tumor progression.
Seliger
Barbara
B
Johannes Gutenberg University, IIIrd Department of Internal Medicine, Johannes Gutenberg Universität, Langenbeckstr. 1D-55101 Mainz, Germany. b.seliger@3-med.klinik.uni-mainz.de
Abken
Hinrich
H
Ferrone
Soldano
S
D005260:Female; D015870:Gene Expression; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A