A new allele within the transmembrane region of the human MICA gene with seven GCT repeats.
Major histocompatibility complex class I chain-related genes (MIC) belong to a multicopy gene family located within the HLA class I region of chromosome 6. They encode for proteins that have a completely different organization, expression, and products from classical HLA class I gene products. One member of this family is the MICA gene, which is characterized by its high degree of polymorphism, with over 50 MICA alleles described. Moreover, MICA exon 5 presents a microsatellite polymorphism consisting of a variable number of GCT repeats that encode for 4, 5, 6, 9, or 10 alanine residues, and a variant (MICA A5.1) that includes a nucleotide insertion (GCT-->GGCT). In this study, we report a novel allele in the transmembrane region of the MICA gene consisting of seven GCT repeats found in a family based study of MICA polymorphism in celiac disease.
Rueda
B
B
Instituto de Parasitlogía y Biomedicina "López-Neyra, CSIC, Granada, Spain.
Pascual
M
M
López-Nevot
M A
MA
González
E
E
Martín
J
J
D001483:Base Sequence; D002446:Celiac Disease / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D018911:Trinucleotide Repeats
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A