An improved procedure for the palladium-catalyzed oxidative carbonylation of beta-amino alcohols to oxazolidin-2-ones.
A highly efficient oxidative cyclocarbonylation of beta-amino alcohols and 2-aminophenol to oxazolidin-2-ones has been achieved by using PdI(2) in conjunction with KI as the catalytic system in DME under relatively mild conditions (100 degrees C and 20 atm of a 4:1 mixture of CO and air).
Gabriele
Bartolo
B
Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende, Cosenza, Italy. b.gabriele@unical.it
Mancuso
Raffaella
R
Salerno
Giuseppe
G
Costa
Mirco
M