Differential functional magnetic resonance imaging language activation in twins discordant for a left frontal tumor.
Eight-year-old twins, one with a left frontal tumor and aphasic seizures, the other neurologically normal, underwent serial assessment of expressive language with functional magnetic resonance imaging and neuropsychology. The affected twin showed a significant amount of right hemisphere activation coincident with behavioral deterioration in expressive language and late growth in the tumor. This pattern of language dysfunction and the left language dominance of her co-twin suggested that the affected twin was also left dominant for language, and the significance of her right activation is discussed. We postulate that the right hemisphere activation represents a stabilizing mechanism in the context of a developmental and progressive lesion in language cortex rather than language transfer per se.
Anderson
Dianne P
DP
Royal Children's Hospital Melbourne, Australia.
Harvey
A Simon
AS
Saling
Michael M
MM
Anderson
Vicki
V
Kean
Michael
M
Jacobs
Rani
R
Abbott
David F
DF
Wellard
R Mark
RM
Puce
Aina
A
Jackson
Graeme
G
D001932:Brain Neoplasms / Q000150:complications* / Q000503:physiopathology*; D002648:Child; D004200:Diseases in Twins; D004292:Dominance, Cerebral; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality; D018303:Ganglioglioma / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007806:Language Disorders / Q000209:etiology* / Q000503:physiopathology*; D007807:Language Tests; D008279:Magnetic Resonance Imaging