[Mutation at the T-cell receptor locus in people a long time after acute and prolonged irradiation].
The frequency of lymphocytes with mutations at genes of T-cell receptor (TCR) is determined in 165 persons exposed to ionizing radiation 16-40 years after the influence. Depending on a type of irradiation and time, elapsed from the moment of exposure, all inspected persons were divided into 3 groups: 1) the analysis performed 16-40 years after acute irradiation; 2) the analysis--9-13 years after acute irradiation; 3) the analysis--9-13 years after prolonged irradiation. The persons with elevated frequencies of TCR-mutant cells were detected in all three groups. In the first group they have compounded 36% of persons inspected, in the second--25%, in the third--15%. The percentage of persons with elevated frequencies of mutant cells in all groups was significantly higher than in control groups. Taking into account fast enough elimination of radiation-induced TCR-mutant cells it is possible to suspect, that the cause of elevated frequency of mutant cells in the part of the persons can be genome instability.
Smirnova
S G
SG
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. sgsmirn@mail.ru
Orlova
N V
NV
Zamulaeva
I A
IA
Saenko
A S
AS
D006801:Humans; D009154:Mutation; D011831:Radiation Genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D011948:Receptors, Antigen, T-Cell