[The effect of leukotriene antagonist on the parameters of dose-response curve obtained after methacholine challenge test].
OBJECTIVE
To investigate the effect of leukotriene antagonist (zafirlucast) on the parameters of dose-response curve (DRC) obtained after methacholine challenge test.


METHODS
A therapy trial was conducted with the use of zafirlucast in 20 cases of cough variant asthma (CVA) and 20 cases of asthma. Placebo was used in 4 cases of CVA and 10 cases of asthma for comparison with the two therapy groups respectively. Before and after the zafirlucast treatment a series of parameters of DRC were obtained after the methacholine challenge test and were calculated. These included the response threshold (PC35sGaw), the dose-response slope (DRS), the ratio of the area under the curve to the logarithm of the maximal concentration (AUC/1 g[Cmax]), and the maximal response.


RESULTS
Zafirlucast significantly increased the PC35sGaw in the CVA and asthma groups. It conspicuously decreased all the parameters of DRS and AUC/1 g[Cmax] except for maximal response in the cases of CVA, and it had no significant effects on all the parameters of DRS and AUC/1 g[Cmax] except for PC35sGaw in the cases of asthma.


CONCLUSIONS
Short-term use of Zafirlucast in asthmatic patients could improve the parameters of dose-response curve obtained after the methacholine challenge test.
Chen
X
X
Department of Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Feng
Y
Y
Luo
Y
Y
Yuan
Y
Y
He
T
T
Zeng
J
J
D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged
D018927:Anti-Asthmatic Agents; D016085:Bronchoconstrictor Agents; D020024:Leukotriene Antagonists; D016210:Methacholine Chloride