title: [MRI in Crohn's disease after transduodenal contrast administration using negative oral MRI contrast media].
abstract: OBJECTIVE
  To compare the efficacy and quality of conventional and MR enteroclysis with different filling methods regarding the assessment of extension and extraluminal manifestations in Crohn's disease.
  
  
  METHODS
  190 patients with known Crohn's disease were studied following small bowel enteroclysis, after oral administration or direct transduodenal filling in the MRI-department.T1- and T2-weighted breathhold MRI-scans w/o spectral fat suppression w/o i.v. Gd-DTPA were applied using negative oral superparamagnetic contrast media.
  
  
  RESULTS
  Typical findings were marked bowel wall thickening with laminated wall contrast enhancement. In 135 patients 98,2% of affected bowel segments, 97,5% of stenoses and all 16 fistulas were detected, when conventional enteroclysis was employed as standard of reference. Additional important extraluminal findings such as ileoileal (n = 18), ileosigmoidal adhesions (n = 12), extraluminal abscesses (n = 35) and pseudotumors (n = 8) were visualized in 73/135 patients. Concerning the distension of jejunum and ileum, oral filling was rated significantly inferior to transduodenal filling in all small bowel segments,whereas filling in the MRI-unit was rated superior to fluoroscopic, mostly due to a mean transport time of 20 min to the MRI-unit.
  
  
  CONCLUSIONS
  No clinically important findings of enteroclysis were missed when using MRI. Therefore, in patients with Crohn's disease, conventional enteroclysis can be replaced by MRI. For optimal bowel distension oral contrast administration is inferior to transduodenal filling, if a larger time delay between filling and the MRI-scan can be avoided.
authors.affiliation: Institut für Klinische Radiologie, Klinikum Grosshadern, Ludwig-Maximilians-Universität München, Munich. holzknecht@ikra.med.uni-muenchen.de
authors.forename: N
authors.initials: N
authors.lastname: Holzknecht
authors.forename: T
authors.initials: T
authors.lastname: Helmberger
authors.forename: K
authors.initials: K
authors.lastname: Herrmann
authors.forename: T
authors.initials: T
authors.lastname: Ochsenkühn
authors.forename: B
authors.initials: B
authors.lastname: Göke
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage*; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004733:Enema; D005260:Female; D005471:Fluoroscopy; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA