[The study of human papillomavirus(HPV) DNA expression in middle-ear carcinomas].
OBJECTIVE
To study the expressions of human papillomavirus DNA in the middle-ear carcinomas.


METHODS
A PCR method using consensus primers for the detection of HPV6,11,16,18 was applied in 5 biopsies of middle-ear carcinomas. Eight biopsies of mucosa in middle-ear and mastoid were concluded as controls.


RESULTS
It was found that a resulting 80% (4/5) of the middle-ear carcinomas contained high-risk-type HPV DNA, while the 0%(0/8) of the controls.


CONCLUSIONS
The high prevalence of high-risk-type HPV in carcinomas of the middle ear suggests that viral infections may be an important etiologic component in the carcinogenic process.
Wang
M
M
Department of Otorhinolaryngology, Third Hospital of Beijing University, Beijing 100083.
Hu
M
M
Liu
C
C
Liu
S
S
D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D004428:Ear Neoplasms / Q000821:virology*; D004432:Ear, Middle / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections; D014412:Tumor Virus Infections
D004279:DNA, Viral