title: Coronary calcium detected by digital cinefluoroscopy and coronary artery disease in patients undergoing coronary arteriography: effects of age and sex.
abstract: BACKGROUND
  Coronary artery calcium, detected non-invasively, correlates well with angiographically documented coronary artery disease (CAD). This study was conducted to evaluate the diagnostic efficacy of coronary artery calcium detected by digital cinefluoroscopy for CAD and assess the effects of age and sex on it.
  
  
  METHODS
  In 242 patients who underwent coronary angiography, coronary calcium status was determined and related to angiographic findings.
  
  
  RESULTS
  Calcium detection had a sensitivity 85%, specificity 52%, positive predictive value 92%, negative predictive value 33% and diagnostic accuracy 81% for significant CAD. There was a better positive predictive value in men (95% vs. 80%) and negative predictive value in women (65% vs. 16%), while a higher sensitivity and diagnostic accuracy was found in older than in younger (90% and 86% vs. 78% and 74%). The sensitivity of the method increased with the number of the diseased vessels.
  
  
  CONCLUSIONS
  Coronary calcium can be quite accurately detected by digital cinefluoroscopy. This, however, should be made in the context of sex and age.
authors.affiliation: Division of Cardiology, Department of Medicine, University of Patras Medical School, 26500 Rio, Patras, Greece. dcalex@otenet.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
authors.forename: Theodoros
authors.initials: T
authors.lastname: Toulgaridis
authors.forename: Periklis
authors.initials: P
authors.lastname: Davlouros
authors.forename: John
authors.initials: J
authors.lastname: Christodoulou
authors.forename: Christos
authors.initials: C
authors.lastname: Stathopoulos
authors.forename: George
authors.initials: G
authors.lastname: Hahalis
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002118:Calcium / Q000032:analysis; D016009:Chi-Square Distribution; D002933:Cineradiography / Q000379:methods*; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution
chemical_list: D002118:Calcium