Region-specific apoptosis limits neural stem cell proliferation.
Regulation of stem cell division is of particular interest, both for studies of development and for stem cell therapeutics. In this issue of Neuron, Bello et al. show that the number of divisions of Drosophila neural stem cells is limited, in a region-specific manner, by regulated apoptosis in response to a pulse of expression of the Hox gene abdominal-A (abdA).
Brand
Andrea H
AH
Wellcome Trust/Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom.
van Roessel
Peter J
PJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division; D019070:Cell Lineage; D004330:Drosophila; D008938:Mitosis / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*