title: A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein.
abstract: A model for the cytoplasmic domain of the M2 proton channel of influenza A virus was formulated based primarily on the cytoplasmic domain of the Vpu protein of HIV-1 using sequence similarity and structure prediction techniques. The model consists of a pair of antiparallel helices followed by a strand parallel to the first helix. Structural analogies with other proteins contribute support for features of the model and suggest ways in which the M2 cytoplasmic domain can interact with other viral and cellular factors.
authors.affiliation: Divisions of Mathematical Biology, NIMR, Mill Hill, London, NW7 1AA, UK. jsaldan@nimr.mrc.ac.uk
authors.forename: José W
authors.initials: JW
authors.lastname: Saldanha
authors.forename: Peter E
authors.initials: PE
authors.lastname: Czabotar
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Hay
authors.forename: William R
authors.initials: WR
authors.lastname: Taylor
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism; D054298:Human Immunodeficiency Virus Proteins; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary / Q000502:physiology; D016415:Sequence Alignment; D012694:Serine / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics / Q000378:metabolism*; D000086082:Viroporin Proteins
chemical_list: D054298:Human Immunodeficiency Virus Proteins; D012694:Serine; D014763:Viral Matrix Proteins; D054334:Viral Regulatory and Accessory Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C514859:vpu protein, Human immunodeficiency virus 1