title: [The proliferating cells in the rat endolymphatic sac].
abstract: OBJECTIVE
  To study the cellular proliferating activity of the endolymphatic sac.
  
  
  METHODS
  10 healthy adult S-D rats were used for the experiment. After administration of 5-bromo-2'-deoxyuridine (BrdUrd) intraperitoneally, the rats were sacrificed and the temporal bones were removed, then the decalcified samples examined immunohistochemically by using monoclonal antibodies against BrdUrd.
  
  
  RESULTS
  Scattered BrdUrd+ cells were detected within the endolymrhatic sac (ES) whereas labelled cells were not fonnd in the cochlea.
  
  
  CONCLUSIONS
  Possessing a low rat of mitotic activity, the ES may be an important the sole site for the cell-renewing in the inner ear.
authors.affiliation: Department of Otolaryngology, Union Hospital, Tongji Medical University, Wuhan 430022.
authors.forename: X W
authors.initials: XW
authors.lastname: Huang
authors.forename: H J
authors.initials: HJ
authors.lastname: Xiao
authors.forename: J B
authors.initials: JB
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Huang
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D004712:Endolymphatic Sac / Q000166:cytology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016196:S Phase / Q000502:physiology
chemical_list: D001973:Bromodeoxyuridine