Influence of the apolipoprotein E type 4 allele on cerebral glucose metabolism in Alzheimer's disease patients.
It is still unclear whether apolipoprotein E epsilon 4 (APOE E4) influences the cerebral glucose metabolism abnormalities found in Alzheimer's disease (AD), although APOE E4 is a well-known risk factor for AD. [(18)F]Fluorodeoxyglucose PET was conducted in patients with very mild (n=17), mild (n=27), and moderate-to-severe (n=19) AD. The presence of APOE E4 was associated with greater reduction of glucose metabolism in the left inferior temporal region in very mild AD but neither in mild nor in moderate-to-severe AD. These findings favor the hypothesis that APOE E4 is related mainly to the development of AD, not to its progression.
Lee
Kang U
KU
Department of Neuropsychiatry, Kangwon National University College of Medicine, Chunchon, South Korea.
Lee
Jae S
JS
Kim
Ki W
KW
Jhoo
Jin H
JH
Lee
Dong Y
DY
Yoon
Jong C
JC
Lee
Jung H
JH
Lee
Dong S
DS
Lee
Myung C
MC
Woo
Jong I
JI
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000145:classification / Q000000981:diagnostic imaging / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18