title: Primary Hodgkin's disease of the nasopharynx: a rare but bona fide disease.
abstract: We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated polypoid mass of the nasopharynx was observed in a 41-year-old man presenting with increasing bilateral nasal obstruction. Histological study revealed a mixed cellularity type of Hodgkin's disease. Immunohistochemical analysis revealed CD30 and LMP1 expression and a lack of reactivity to CD15, CD3 and CD20. Serological tests excluded recent infection with Epstein-Barr virus. HD of nasopharynx is rare, but has to be recognized as such in view of appropriate treatment.
authors.affiliation: Histopathology Department, Salah Azaiez Institute, 10006 Bab Saadoun, Tunis, Tunisia.
authors.forename: I
authors.initials: I
authors.lastname: Abbes
authors.forename: K
authors.initials: K
authors.lastname: Mrad
authors.forename: S
authors.initials: S
authors.lastname: Sassi
authors.forename: M
authors.initials: M
authors.lastname: Jellouli
authors.forename: L
authors.initials: L
authors.lastname: Kochbati
authors.forename: M
authors.initials: M
authors.lastname: Maalej
authors.forename: K
authors.initials: K
authors.lastname: Ben Romdhane
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000473:pathology / Q000532:radiotherapy; D004854:Herpesvirus 4, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D008297:Male; D015508:Nasal Obstruction / Q000209:etiology; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D012074:Remission Induction; D012913:Snoring / Q000209:etiology; D014763:Viral Matrix Proteins / Q000032:analysis
chemical_list: D000914:Antibodies, Viral; D014408:Biomarkers, Tumor; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D017730:Ki-1 Antigen; D014763:Viral Matrix Proteins