title: Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients.
abstract: We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.
authors.affiliation: Dipartimento di Medicina Interna, University of Genova, Genoa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Costa
authors.forename: Stefano
authors.initials: S
authors.lastname: Rusconi
authors.forename: Manuela
authors.initials: M
authors.lastname: Fogli
authors.forename: Domenico
authors.initials: D
authors.lastname: Mavilio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Murdaca
authors.forename: Francesco
authors.initials: F
authors.lastname: Puppo
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Mingari
authors.forename: Massimo
authors.initials: M
authors.lastname: Galli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Moretta
authors.forename: Andrea
authors.initials: A
authors.lastname: De Maria
mesh_terms: D000328:Adult; D003602:Cytotoxicity, Immunologic; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D011971:Receptors, Immunologic / Q000097:blood*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D011971:Receptors, Immunologic