title: Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene.
abstract: [reaction: see text] The regioselective palladium(0)-catalyzed arylation of 3-furoate and 3-thiophenecarboxylate esters with aryl bromides is described. Conditions were developed that allow for the selective synthesis of either 2-aryl or 5-aryl products.
authors.affiliation: GlaxoSmithKline, Chemical Development, Five Moore Drive, P O Box 13398, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Bobby
authors.initials: B
authors.lastname: Glover
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Harvey
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sharp
authors.forename: Maria F
authors.initials: MF
authors.lastname: Tymoschenko
mesh_terms: D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D005663:Furans; D013876:Thiophenes; D010165:Palladium