Separation of albendazole sulfoxide enantiomers by chiral supercritical-fluid chromatography.
The enantioseparation of albendazole sulfoxide (ABZSO) by chiral supercritical-fluid chromatography (SFC) on two columns, based on the polysaccharide derivatives Chiralpak AD and Chiralcel OD, was studied. The effect of different modifiers, methanol, ethanol, 2-propanol, and acetonitrile, was examined. The results showed that ABZSO can be separated on both columns, using an alcohol-type modifier. Using the Chiralpak AD column, the best results were obtained with 2-propanol and, in the case of the Chiralcel OD, with methanol.
del Nozal
M J
MJ
Department of Analytical Chemistry, Faculty of Sciences, University of Valladolid, Prado de la Magdalena s/n, E-47005 Valladolid, Spain. mjdnozal@qu.uva.es
Toribio
L
L
Bernal
J L
JL
Nieto
E M
EM
Jiménez
J J
JJ
D000097:Acetonitriles / Q000737:chemistry; D015766:Albendazole / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*; D000438:Alcohols / Q000737:chemistry; D000688:Amylose / Q000031:analogs & derivatives*; D002219:Carbamates; D002482:Cellulose / Q000031:analogs & derivatives*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D048448:Phenylcarbamates; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism
D000097:Acetonitriles; D000438:Alcohols; D002219:Carbamates; D048448:Phenylcarbamates; D012996:Solutions; C065943:cellulose tris-3,5-dimethylphenyl-carbamate; C080033:Chiralpak AD; D002482:Cellulose; D000688:Amylose; D015766:Albendazole; C027186:albendazole sulfoxide; C032159:acetonitrile