t(4;12)(q11;p13): a rare chromosomal translocation in acute myeloid leukemia.
We present a case of acute myeloid leukemia with t(4;12). This translocation is rare and has been observed in acute leukemias with different but immature phenotypes. To the best of our knowledge, there are around 15 descriptions of t(4;12) in AML, and most interesting, presenting morphological aspects of a pseudo-lymphoid cell with dysplasia of other series.
Chauffaille
Maria de Lourdes L F
Mde L
Disciplina de Hematologia e Hemoterapia, Escola Paulista de Medicina-UNIFESP, São Paulo, SP, Brazil. chauffaill@hemato.epm.br
Fermino
Fabiana A
FA
Pelloso
Luis A F
LA
Silva
Maria R R
MR
Bordin
José O
JO
Yamamoto
Mihoko
M
D000208:Acute Disease; D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D014178:Translocation, Genetic