title: [Rat submandibular gland tumor induced by 3-methylcholanthrene].
abstract: OBJECTIVE
  To study the genesis and the development of salivary gland tumor (SGT).
  
  
  METHODS
  SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.
  
  
  RESULTS
  32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.
  
  
  CONCLUSIONS
  Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.
authors.affiliation: Faculty of Stomatology, Henan Medical University.
authors.forename: X
authors.initials: X
authors.lastname: Cao
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: He
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Hao
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D007890:Leiomyosarcoma / Q000139:chemically induced* / Q000473:pathology; D008748:Methylcholanthrene; D051381:Rats; D017207:Rats, Sprague-Dawley; D013365:Submandibular Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D008748:Methylcholanthrene