Analysis of reaction products of morphine and codeine with hydrogen peroxide by high-performance liquid chromatography/mass spectrometry.
Changes in the chemical structures of morphine and codeine in the presence of hydrogen peroxide, a major component of hair dye and decolorant treatments, were examined with high-performance liquid chromatography/mass spectrometry (LC/MS). A mixture of morphine and hydrogen peroxide solution, after incubation at 39 degrees C for 24 h, produced two reaction products (hydroxymorphines). When codeine was used in place of morphine, one reaction product (hydroxycodeine) was produced, in which the benzene ring was hydroxylated.
Tanaka
Seishi
S
Forensic Science Laboratory, Ishikawa Prefectural Police Headquarters, Hirosaka, Kanazawa 920-8553, Japan. tanakase@plum.ocn.ne.jp
Iio
Reiko
R
Chinaka
Satoshi
S
Takayama
Nariaki
N
Hayakawa
Kazuichi
K
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003061:Codeine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D009020:Morphine / Q000737:chemistry*
D009020:Morphine; D006861:Hydrogen Peroxide; D003061:Codeine