title: Allele frequencies of alpha-1-antitrypsin (PI) in the Balkans.
abstract: The phenotype and allele frequencies of alpha-1-antitrypsin has been studied by an IEF technique (pH 4.2-4.9) in ten population samples from the Balkans. The allele frequencies varied from 0.6667 to 0.7361 (*M1), 0.1100 to 0.1793 (*M2), 0.0992 to 0.1700 (*M3), 0 to 0.0105 (*S), 0 to 0.0078 (*Z) and 0 to 0.0172 (others). The results were compared with data from South and Middle European populations from the literature. Most of the populations form a cluster with small genetic distances, and a weak relationship to geographical distributions. In contrast, the samples from Southern France, the Iberian Peninsula and Madeira form a clearly separated cluster. The differences are mainly based on high frequencies of PI*S in the latter populations.
authors.affiliation: Institute of Human Genetics and Anthropology, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: H G
authors.initials: HG
authors.lastname: Scheil
authors.forename: S
authors.initials: S
authors.lastname: Schuhen
authors.forename: W
authors.initials: W
authors.lastname: Huckenbeck
authors.forename: H D
authors.initials: HD
authors.lastname: Schmidt
mesh_terms: D000415:Albania; D002031:Bulgaria; D005787:Gene Frequency; D006115:Greece; D006801:Humans; D010641:Phenotype; D012383:Romania; D015022:Yugoslavia; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000515:alpha 1-Antitrypsin