title: Low interleukin-10 production is associated with higher disability and MRI lesion load in secondary progressive multiple sclerosis.
abstract: Abnormalities in T-cell-derived cytokine production are a well-known phenomenon in multiple sclerosis (MS). An association between disability and the production of interferon gamma has been demonstrated recently. The present study investigated associations between disability, cytokine production in stimulated blood lymphocytes and magnetic resonance imaging data in 37 patients with the secondary progressive course in the stable phase of the disease. Patients with high interleukin-10 (IL-10) production had significantly lower disability scores (p=0.009) and lower T2 lesion load (p=0.03). Interleukin-10 might not only play a role in the pathological process of multiple sclerosis but has an impact on disease outcome as well.
authors.affiliation: Department of Neurology and Psychiatry, University of Cologne, Josef-Stelzmann-Str. 9, D-50924 Cologne, Germany. hela.petereit@medizin.uni-koeln.de
authors.forename: H F
authors.initials: HF
authors.lastname: Petereit
authors.forename: R
authors.initials: R
authors.lastname: Pukrop
authors.forename: F
authors.initials: F
authors.lastname: Fazekas
authors.forename: S U
authors.initials: SU
authors.lastname: Bamborschke
authors.forename: S
authors.initials: S
authors.lastname: Röpele
authors.forename: H W
authors.initials: HW
authors.lastname: Kölmel
authors.forename: S
authors.initials: S
authors.lastname: Merkelbach
authors.forename: G
authors.initials: G
authors.lastname: Japp
authors.forename: P J H
authors.initials: PJ
authors.lastname: Jongen
authors.forename: H P
authors.initials: HP
authors.lastname: Hartung
authors.forename: O R
authors.initials: OR
authors.lastname: Hommes
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001774:Blood Chemical Analysis; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D013223:Statistics as Topic; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma