title: Conversion from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine is safe and cost-effective in patients receiving long-term prophylaxis to prevent hepatitis B recurrence after liver transplantation.
abstract: Recurrent hepatitis B infection after liver transplantation was previously frequent and associated with significant allograft failure and mortality. Recurrence rates of hepatitis B were improved with the use of passive immunoprophylaxis with hepatitis B immune globulin, and later, lamivudine monotherapy. Combination prophylaxis with intravenous hepatitis B immune globulin and lamivudine substantially decreased rates of hepatitis B recurrence, but intravenous administration of hepatitis B immune globulin was expensive and associated with significant adverse effects. In the current study, 59 patients receiving primary liver transplantation for chronic hepatitis B infection were prospectively followed up after converting from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine. All patients tolerated intramuscular hepatitis B immune globulin well. At a median follow-up of 511 days after conversion to intramuscular hepatitis B immune globulin, 58 of 59 patients (98.3%) were hepatitis B surface antigen-negative. Twenty-one patients (35.6%) required a median of one supplemental intravenous hepatitis B immune globulin infusion to maintain therapeutic antibody levels. Economic analysis showed an average cost-effectiveness ratio for combination intramuscular hepatitis B immune globulin plus lamivudine of $52,600 per recurrence prevented, which was far below the cost of lamivudine monotherapy and of intravenous hepatitis B immune globulin alone or in combination with lamivudine. These results suggest that intramuscular administration of hepatitis B immune globulin in combination with lamivudine offers a safe, effective, and cost-effective approach to preventing hepatitis B recurrence after orthotopic liver transplantation.
authors.affiliation: Division of Digestive Diseases, UCLA School of Medicine, Los Angeles, CA, USA. shbhan@ucla.edu
authors.forename: Steven-Huy
authors.initials: SH
authors.lastname: Han
authors.forename: Paul
authors.initials: P
authors.lastname: Martin
authors.forename: Marc
authors.initials: M
authors.lastname: Edelstein
authors.forename: Rena
authors.initials: R
authors.lastname: Hu
authors.forename: Gregg
authors.initials: G
authors.lastname: Kunder
authors.forename: Curtis
authors.initials: C
authors.lastname: Holt
authors.forename: Sammy
authors.initials: S
authors.lastname: Saab
authors.forename: Francisco
authors.initials: F
authors.lastname: Durazo
authors.forename: Leonard
authors.initials: L
authors.lastname: Goldstein
authors.forename: Douglas
authors.initials: D
authors.lastname: Farmer
authors.forename: Rafik M
authors.initials: RM
authors.lastname: Ghobrial
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Busuttil
mesh_terms: D000328:Adult; D000368:Aged; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D004359:Drug Therapy, Combination; D005260:Female; D006085:Graft Survival; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000191:economics*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D019259:Lamivudine / Q000191:economics* / Q000627:therapeutic use*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D018894:Reverse Transcriptase Inhibitors / Q000191:economics* / Q000627:therapeutic use*; D012449:Safety; D055502:Secondary Prevention; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; C045213:hepatitis B hyperimmune globulin