[Inhibitory Effects of Etoposide Combined with 8-methoxypsoral en on Highly Metastatic Human Mucoepidermoid Carcinoma Cells].
OBJECTIVE
To study the inhibitory effects of Etoposide (VP16) combined with 8-methoxypsoralen (8-MOP) on human highly metastatic mucoepidermoid carcinoma cells (Mc3).


METHODS
Mc3 cells were exposed to the drugs and their combinations at various concentrations. The inhibitory effects were tested with microculture tetrazolium colorimetric assay (MTT assay) and cologenic assay.


RESULTS
The IC50 values of VP16 and 8-MOP were 1625. 25 ng/ml and 750000 ng/ml respectively, the CI50 of the combination at 100320 and 1000 ng/ml of VP16 with 8-MOP were 0.350, 0.599 and 0.880 respectively.


CONCLUSIONS
The data indicate that combination of VP16 and 8-MOP is synergic in the inhibition of Mc3 cell growth.
Li
Y
Y
Wu
J
J
Situ
Z
Z
Liu
B
B
Han
J
J
D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004357:Drug Synergism; D005047:Etoposide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage / Q000494:pharmacology*; D009362:Neoplasm Metastasis; D014407:Tumor Cells, Cultured
D005047:Etoposide; D008730:Methoxsalen