[Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional therapy for periodontitis].
OBJECTIVE
This study was designed to evaluate the clinical effects of metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for periodontitis.


METHODS
13 patients with adult periodontitis were selected and each of them had two or more sites with probing depth > or = 4 mm, so totally 35 teeth were included in this study. After conventional therapy, the subjects were randomly divided into three groups: (1) experimental group application with MO gel, (2) standard group application with metronidazole stitus, and (3) control group application with placebo gel. Local application was performed once a week for 12 weeks. Clinical parameters including PD, PAL, GI, BOP, PLI was recorded after 6 weeks and 12 weeks respectively.


RESULTS
All clinical parameters from group of gel and group of metronidazole stilus were better than that from control group, while no significant difference was observed between MO gel group and metronidazole stilus group.


CONCLUSIONS
It indicates local application with MO gel treatment as an adjunct to conventional therapy may lead to a more advantageous outcome for periodontitis.
Yang
H
H
College of Stomatology, West China University of Medical Sciences.
Wang
X
X
Xu
Y
Y
Zhang
J
J
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy*
D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005782:Gels; D008795:Metronidazole