Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion.
A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.
Toorisaka
Eiichi
E
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Hakozaki, 812-8581, Fukuoka, Japan.
Ono
Hiroshige
H
Arimori
Kazuhiko
K
Kamiya
Noriho
N
Goto
Masahiro
M
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004655:Emulsions / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007328:Insulin / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D009821:Oils / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014867:Water / Q000737:chemistry
D004655:Emulsions; D007004:Hypoglycemic Agents; D007328:Insulin; D009821:Oils; D013501:Surface-Active Agents; D014867:Water