[The expression of the epidermal growth factor-receptor mRNA in laryngeal squamous cell carcinoma and its correlation with clinical pathological characteristics].
OBJECTIVE
To study the expression of the epidermal growth factor-receptor(EGF-R) mRNA in laryngeal squamous cell carcinoma and its correlation with clinical characteristic and difference of tissues.


METHODS
All 20 samples of laryngeal squamous cell carcinoma were determined by dot blot.


RESULTS
The EGF-R mRNA expression was evaluated in 20 laryngeal squamous cell carcinomas and 15(75%) were finded with EGF-R mRNA expression. When the mRNA of the laryngeal squmous cell carcinoma was decreased, the expression of the EGF-R mRNA was decreased. The EGF-R mRNA expression did not correlated with age or tumor localization (P > 0.05) but correlated with differentiated tumors (P < 0.05) and the stages of TNM according to classification (P < 0.05). Four patients with recuence cancers and six patients with the metastatic cervical-lymph-node involvement had an enhanced expression of EGF-R mRNA.


CONCLUSIONS
The uncontrolled growth and proliferation of the laryngeal squmous cell carcinomas may be related to the abnormal EGF-R mRNA expression. The enhanced expression of EGF-R mRNA was correlated with the differentiation and stages of laryngeal squmous cell carcinomas.
Fu
Z
Z
Department of Otolaryngology, Union Hospital of Tongji Medical University, Wuhan 430022.
Wang
J
J
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000096:biosynthesis
D012333:RNA, Messenger; D066246:ErbB Receptors