[An experimental study on the blood vessel sclerosing therapeutic agents for cavernous hemangiomas].
OBJECTIVE
This study was designed to test what are the suitable drugs for sclerotherapy and investigate the formation mechanism of cavernous hemangiomas.


METHODS
A total of 84 rabbits were selected for this study, and divided into 6 groups, including one control group and five experimental groups. We selected auricular veins of rabbits as the location of injection. The rabbits of the control were injected with physiological saline, and the rabbits of the experimental groups were injected respectively with various drugs, including 5% sodium morrhuate, 10% alum, pinyungmycin, leurocristine and the combination of pinyungmycin and dexamethasone. Histopathological changes were analyzed after 3, 7, 14, 21, 28, 35 days of sclerotherapy.


RESULTS
According to histopathological changes of tissue, 5% sodium morrhuate, 10% alum, and the combination of pinyungmycin and dexamethasone produced better eutherapeutic effects, when comparing with other methods. However, 5% sodium morrhuate caused tissue necrosis of the injection site.


CONCLUSIONS
The combined therapy of pinyungmycin and dexamethasone produced excellent sclerotic effects. Whatever drugs causing serious damage of HVEC may contribute to the therapy for cavernous hemangiomas.
Guo
J
J
Department of Stomatology, Second Affiliated Hospital, Hunan Medical University.
Wu
H
H
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004423:Ear / Q000098:blood supply; D006392:Hemangioma, Cavernous / Q000628:therapy*; D011817:Rabbits; D015911:Sclerotherapy; D014680:Veins / Q000473:pathology
D001761:Bleomycin; D003907:Dexamethasone