title: [Morphological peculiarities of rat liver reaction to chronic xenobiotic exposure].
abstract: The data of the morphological studies of liver of animals subjected to chronic (3 months long) intoxication with different chemical substances (ammonium nitrogen, nitrite nitrogen, fluorine, chromium, arsenic) are presented. The xenobiotics tested induced stereotyped responses in liver which differed in their intensity and the extent of hemomicrocirculatory and inflammatory-destructive alterations. Most pronounced reactive changes were found in animals exposed to arsenic compounds, while sodium nitrate caused practically no destructive changes in hepatocytes.
authors.affiliation: Department of Pathophysiology and Department of Histology and Embryology, 2nd Tashkent Medical Institute, Uzbekistan.
authors.forename: Kh Ia
authors.initials: KhIa
authors.lastname: Karimov
authors.forename: F Sh
authors.initials: FSh
authors.lastname: Inoiatov
authors.forename: Sh N
authors.initials: ShN
authors.lastname: Dadazhanov
authors.forename: R I
authors.initials: RI
authors.lastname: Israilov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis; D051381:Rats; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D015262:Xenobiotics