[Rat submandibular gland tumor induced by 3-methylcholanthrene].
OBJECTIVE
To study the genesis and the development of salivary gland tumor (SGT).


METHODS
SGT animal models were established by injection of 3-methylcholanthrene (3-MCA) oil solution into 40 submandibular glands of Sprague-Dawley (SD) rats, then histopathology and ultrastructure of induced tumors were observed under microscope, and immunohistochemical detection of keratin and actin was carried out.


RESULTS
32 models of submandibular gland tumors were induced successfully, with 4 rats of squamous cell carcinoma and 28 leiomyosarcoma, and the carcinogenesis of 3-MCA and tissue genesis of induced tumors were discussed.


CONCLUSIONS
Submandibular gland tumor can be induced by 3-MCA, and sarcoma was of high incidence.
Cao
X
X
Faculty of Stomatology, Henan Medical University.
Liu
X
X
He
W
W
Liu
X
X
Hao
Z
Z
Zhao
Q
Q
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D007890:Leiomyosarcoma / Q000139:chemically induced* / Q000473:pathology; D008748:Methylcholanthrene; D051381:Rats; D017207:Rats, Sprague-Dawley; D013365:Submandibular Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008748:Methylcholanthrene