Synaptogenesis: Wnt and TGF-beta take centre stage.
The formation of functional synapses requires precise coordination between neurons and their synaptic targets. Recent studies have identified two signaling molecules, Wnt and TGF-beta, which are required for formation and growth of the neuromuscular synapse.
Salinas
Patricia C
PC
Department of Biological Sciences, Imperial College London, Exhibition Road, SW8 2AZ, London, UK. p.salinas@ic.ac.uk
D000818:Animals; D004330:Drosophila / Q000254:growth & development / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D008959:Models, Neurological; D009469:Neuromuscular Junction / Q000254:growth & development / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins; C074622:wg protein, Drosophila