[The alterations in vasoactive intestinal polypeptide-immune reaction positive neurons of cerebral tissues in epileptic rats induced by penicillin].
To further explore the action of vasoactive intestinal polypeptide(VIP) in epileptogenesis, we made an immunocytochemical analysis and observed the alterations in VIP-energic neurons of the cerebral cortex, hippocampus and amygdaloid in rats. The animals were divided into three groups: the control, the epileptic group in which seizure was induced by injected Penicillin(PNC) intraperitoneally, and the nimodipline(NIM) group in which seizure was impressed by giving PNC after NIM, a dihydropyridine calcium entry blocker, was injected. The results showed that the number of neurons of epileptic group increased, compared with that of control group (P < 0.01), the neuronic number of the epileptic group was higher than that of the NIM group(P < 0.01), whereas there was no significant difference in neuronic number between the control group and the NIM group(P > 0.05). These suggest that VIP and Ca2+ participate in the process of epileptogenesis.
Zou
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Department of Neurology, First Affiliated Hospital, WCUMS, Chengdu, 610041.
Ruan
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D010406:Penicillins; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
D010406:Penicillins; D014660:Vasoactive Intestinal Peptide; D002118:Calcium