Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen.
BACKGROUND
Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer.


METHODS
A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori, including 5 cagA+ strains.


RESULTS
Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml.


CONCLUSIONS
These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.
Mahady
G B
GB
Department of Pharmacy Practice, College of Pharmacy, WHO Collaborating Centre for Traditional Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. mahady@uic.edu
Pendland
S L
SL
Yun
G
G
Lu
Z Z
ZZ
D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology
D010936:Plant Extracts; D003474:Curcumin; D000432:Methanol