title: Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
abstract: Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
authors.affiliation: National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC. lclin@cma23.nricm.edu.tw
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Yang
authors.forename: Cheng-Jen
authors.initials: CJ
authors.lastname: Chou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D007651:Keto Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D029606:Plumbaginaceae / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D005960:Glucosides; D007651:Keto Acids; D009285:Naphthoquinones