title: Solitary splenic recurrence of epithelial ovarian cancer: a case report and review.
abstract: The metastatic involvement of the spleen in epithelial ovarian cancer is rare and usually reflects late disseminated disease. Isolated parenchymal metastasis in the spleen is an extremely unusual event, in fact in most cases in medical literature, the spleen was involved as part of diffuse peritoneal carcinomatosis. We report a rare case of epithelial ovarian carcinoma, which recurred in the splenic parenchyma 15 years after initial treatment. The patient underwent a splenectomy followed by six cycles of platinum-based poly-chemotherapy. Currently, 8 years after splenectomy, the patient has no evidence of relapsed disease. In the solitary splenic recurrence of epithelial ovarian cancer our case suggests that accurate surgical resection of the spleen, followed by platinum-based chemotherapy, is correlated with a prolonged survival.
authors.affiliation: Chair of Medical Oncology, La Sapienza University of Rome, 2nd Faculty of Medicine and Surgery, Azienda Policlinico S. Andrea, Via di Grottarossa 1035, 00189, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Lauro
authors.forename: L
authors.initials: L
authors.lastname: Trasatti
authors.forename: C
authors.initials: C
authors.lastname: Capalbo
authors.forename: A
authors.initials: A
authors.lastname: Conti
authors.forename: F
authors.initials: F
authors.lastname: Ricci
authors.forename: P L
authors.initials: PL
authors.lastname: Mingazzini
authors.forename: A
authors.initials: A
authors.lastname: Vecchione
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000556:secondary* / Q000601:surgery