In vitro and in vivo models for assessing drug efflux transporter activity.
Determining the activity of drug efflux transport proteins has important implications in the identification of substrates and/or inhibitors of the various transport systems, as well as mechanistic determination of localization, and functional role of the transporters in absorption, distribution and elimination of compounds in the body. This review examines both in vitro and in vivo approaches used to determine drug efflux transporter activity, their applications, and advantages and potential limitations.
Zhang
Yan
Y
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA.
Bachmeier
Corbin
C
Miller
Donald W
DW
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D030801:Animals, Genetically Modified; D001693:Biological Transport, Active; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011922:Rats, Mutant Strains
D018528:ATP-Binding Cassette Transporters; D004364:Pharmaceutical Preparations