[Relationship between sex hormone levels and blood calcitonin gene-related peptide/endothelin-1 in postmenopausal women with coronary heart disease].
OBJECTIVE
To investigate the relationship between sex hormone levels and blood calcitonin gene-related peptide/endothelin-1, and to evaluate the therapeutic effects of nylestriol.


METHODS
Forty perimenopausal women without coronary heart disease (CHD) and 30 postmenopausal women with CHD were studied, and 30 postmenopausal women were divided into two groups and treated randomly with either 2 mg nylestriol or placebo. Serum 17 beta-estradiol (E2), testosterone (T), plasma calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1) were measured.


RESULTS
In postmenopausal women, serum levels of E2 and plasma concentrations of CGRP decreased, while serum levels of T and plasma concentrations of ET-1 increased; E2 was positively related to CGRP, and negatively related to ET-1; T was negatively related to CGRP or ET-1. In the nylestriol group, compared with the parameters before treatment, plasma CGRP increased and ET-1 decreased after treatment.


CONCLUSIONS
Estradiol possesses certain effects on endothelial cell, which may be an important aspect of its protective effects.
Ma
Q L
QL
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhou
H Y
HY
Sun
M
M
D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D019332:Endothelin-1 / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D045166:Estradiol Congeners / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D019332:Endothelin-1; D045166:Estradiol Congeners; D004958:Estradiol; C010722:nylestriol; D015740:Calcitonin Gene-Related Peptide; D011800:Quinestrol