title: Prognostic value of glucose transporter 1 expression in patients with hypopharyngeal carcinoma.
abstract: BACKGROUND
  The increase of glucose transport is a distinguishing marker of tumor cells. We hypothesized that a hypopharyngeal carcinoma, characterized by high frequency of lymph node spread or distant metastasis, was associated with glucose transporter 1 (Glut 1) overexpression.
  
  
  METHODS
  We investigated the incidence of Glut1 expression by immunostaining in 99 patients with hypopharyngeal carcinoma, and revealed the correlation with the clinical characteristics.
  
  
  RESULTS
  The analysis showed 46 patients (46%) of Glut1 overexpression (> 70% tumor cell stained). Glut1 expression did not correlate with gender, subsite, histological grade, tumor size, lymph node status or stage grouping. The 5-year relapse-free survival (RFS) rate of patients with Glut1 overexpression (> 70%) (35%) was significantly lower than that of patients with low Glut1 expression (< or = 70%) (57%) (p = 0.047). Multivariate analysis showed that advanced tumor stage (stages III and IV) and Glut1 overexpression were predictors of reduced RFS (p = 0.031 and 0.021, respectively).
  
  
  CONCLUSIONS
  Glut1 expression is an indicator for predicting the prognosis of hypopharyngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Hamamatsu University School of Medicine, Hamamatsu, Japan. mineta@hama-med.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mineta
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Miura
authors.forename: Satoru
authors.initials: S
authors.lastname: Takebayashi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Misawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Araki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Misawa
authors.forename: Yoh
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D051272:Glucose Transporter Type 1; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000096:biosynthesis*; D015999:Multivariate Analysis; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human