[Expression of Fas and Fas ligand in lesions of patients with discoid lupus erythematosus].
OBJECTIVE
To study the relation of apoptosis and pathogenesis of lupus erythematosus.


METHODS
Expressions of Fas and Fas ligand(FasL) were detected in 30 lesions of discoid lupus erythematosus(DLE) and 5 skin specimens from healthy controls by immunohistochemical staining.


RESULTS
Fas and FasL were positively expressed in most epidermal keratinocytes, infiltrating lymphocytes around blood vessels and appendages, and Fas was positively expressed in a few sweat ducts and hair follicles. Fas and FasL expressions were weakly positive or negative in healthy controls.


CONCLUSIONS
Apoptosis induced by Fas, FasL pathway may be related to the pathogenesis of lupus erythematosus.
Zhang
M
M
Department of Dermatology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Zhang
Y
Y
Wang
L
L
Li
F
F
D000328:Adult; D000368:Aged; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D053222:Fas Ligand Protein; D005260:Female; D029941:Fish Proteins; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry; D008179:Lupus Erythematosus, Discoid / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis / Q000096:biosynthesis*; D008875:Middle Aged; D011897:Random Allocation; D012867:Skin / Q000737:chemistry*; D014157:Transcription Factors / Q000032:analysis / Q000096:biosynthesis*
D004268:DNA-Binding Proteins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C109105:Fash1 protein, Takifugu rubripes; D029941:Fish Proteins; D008562:Membrane Glycoproteins; D014157:Transcription Factors