title: Fetal liver hyperechogenicity on sonography may be a serendipitous sign of a transient myeloproliferating disorder.
abstract: OBJECTIVE
  To demonstrate that thorough antenatal and postnatal investigations are helpful in any genetic syndrome.
  
  
  METHODS
  A woman without a specific risk had a finding of hyperechogenic foci at ultrasound. Karyotype on fetal blood was 47, XY+21 and extensive biochemical investigation revealed abnormal liver function. Given the suspicion of a coincidental hepatic compromise, targeted postmortem examination was performed, which showed hepatic fibrosis, megakaryocytes proliferation and invasion of sinusoid capillaries, all suggestive of a transient myeloproliferative disorder.
  
  
  CONCLUSIONS
  When compared with chorionic villous and amniotic fluid sampling, fetal blood allows the collection of additional data, which may help in understanding the pathological process behind an apparently serendipitous association.
authors.affiliation: Institute of Obstetrics and Gynaecology-University of Bari, Italy. avimercati@gynecology2.uniba.it
authors.forename: Antonella
authors.initials: A
authors.lastname: Vimercati
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Greco
authors.forename: Antonia
authors.initials: A
authors.lastname: Gentile
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ingravallo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Loverro
authors.forename: Luigi
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000025:Abortion, Eugenic; D000328:Adult; D000649:Amniocentesis; D015193:Chorionic Villi Sampling; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000196:embryology; D008103:Liver Cirrhosis / Q000151:congenital / Q000473:pathology; D008111:Liver Function Tests; D008533:Megakaryocytes / Q000378:metabolism / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000151:congenital / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
chemical_list: D005169:Factor VIII