New minor taxanes analogues from the needles of Taxus canadenis.
Seven new taxanes were isolated from the needles of the Canadian yew: unusual functional groups, positions and/or stereochemical features are described. Their chemical structures were rigorously characterized by detailed high resolution NMR analyses and confirmed by high resolution Fast Atom Bombardment Mass Spectrometry. Unlike paclitaxel and taxuspine D, these taxanes had no effect on tubulin assembly.
Shi
Qing Wen
QW
Human Health Research Center, INRS-Institut Armand-Frappier, Universite du Quebec, 531 Boulevard des Praries, Laval, Quebec, Canada H7V 1B7.
Sauriol
Françoise
F
Mamer
Orval
O
Zamir
Lolita O
LO
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D043823:Taxoids; D020946:Taxus / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D043823:Taxoids; C094551:taxuspine D; C080625:taxane; D017239:Paclitaxel