title: Tumor angiogenesis of non-small cell lung cancer.
abstract: Lung cancer is one of the commonest causes of cancer death in developed countries. Recent evidence suggests that angoigenesis is related to poor prognosis in many solid tumors including non-small cell lung cancer (NSCLC). Angiogenesis is regulated by a complex interaction among growth factors and cytokines and influenced by proteolytic enzymes such as plasminogen activators and matrix metalloproteases, expression of adhesion molecules, and distribution of extracellular matrices. Fibroblasts, macrophages, mast cells, and endothelial cells themselves also affect angiogenesis. This review concentrates on angiogenic growth factors including vascular endothelial growth factor, angiopoietins, platelet derived endothelial growth factor, and basic fibroblast growth factor, proteases, adhesion molecules including vascular endothelial cadherin and integrins, osteopontin, and mast cell products in tumor angiogenesis of NSCLC.
authors.affiliation: Third Department of Internal Medicine and Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan. shijubo@sapmed.ac.jp
authors.forename: Noriharu
authors.initials: N
authors.lastname: Shijubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
authors.forename: Manabu
authors.initials: M
authors.lastname: Nagata
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohchi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Suzuki
authors.forename: Shosaku
authors.initials: S
authors.lastname: Abe
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sato
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology; D016228:Endothelial Growth Factors / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000473:pathology; D008407:Mast Cells / Q000502:physiology; D009389:Neovascularization, Pathologic; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D016228:Endothelial Growth Factors; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin; D010450:Endopeptidases