[Effects of monoclonal antibody against the major cell surface protein on salivary agglutinin mediated aggregation of Streptococcus sobrinus].
OBJECTIVE
To investigate the effects of monoclonal antibody on salivary agglutinin-mediated aggregation of Streptococcus sobrinus in vitro.


METHODS
Bacterial aggregation inhibition was measured under OD650 at 10 minutes intervals for 1 hour.


RESULTS
It showed that the McAb ZS2/286 raised against the PAg of S. sobrinus 6715 could inhibit the aggregation by some degree, but the effect was not significant.


CONCLUSIONS
The McAb ZS2/286 might not bind directly to the functionally important region of PAg related to aggregation.
Zhang
P
P
College of Stomatology, Hubei Medical University.
Fan
M
M
Bian
Z
Z
D000373:Agglutinins / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001422:Bacterial Adhesion / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D012463:Saliva / Q000276:immunology*; D016986:Streptococcus sobrinus / Q000276:immunology*
D000373:Agglutinins; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial