title: Detection of gene expression pattern in the early stage after spinal cord injury by gene chip.
abstract: OBJECTIVE
  To study the changes of the gene expression pattern of spinal cord tissues in the early stage after injury by DNA microarray (gene chip).
  
  
  METHODS
  The contusion model of rat spinal cord was established according to Allen's falling strike method and the gene expression patterns of normal and injured spinal cord tissues were studied by gene chip.
  
  
  RESULTS
  The expression of 45 genes was significantly changed in the early stage after spinal cord injury, in which 22 genes up-regulated and 23 genes down-regulated.
  
  
  CONCLUSIONS
  The expression of some genes changes significantly in the early stage after spinal cord injury, which indicates the complexity of secondary spinal cord injury.
authors.affiliation: Department of Orthopedics, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. lclong@mail.china.com
authors.forename: Cheng-long
authors.initials: CL
authors.lastname: Liu
authors.forename: An-min
authors.initials: AM
authors.lastname: Jin
authors.forename: Bin-hui
authors.initials: BH
authors.lastname: Tong
mesh_terms: D000818:Animals; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D016762:Genes, fos / Q000235:genetics; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000235:genetics*; D015854:Up-Regulation