title: [Calcium dependent synaptic plasticity].
abstract: Recent work shows that the intracellular free Ca2+ concentrations ([Ca2+]i) of the presynaptic and postsynaptic neurons play crucial signaling roles in short- and long-term synaptic plasticity. Residual [Ca2+]i followed conditioning stimulation may cause short-term synaptic enhancement. Presynaptic [Ca2+]i could influence the replacing of presynaptic depressed vesicles, as well as encode the precise relative timing of presynaptic input and postsynaptic activity and generate long-term synaptic modification of opposite polarity(LTP or LTD).
authors.affiliation: Department of Pathophysiology, Qingdao Medical College, Qingdao 266021.
authors.forename: Y
authors.initials: Y
authors.lastname: Dou
authors.forename: J
authors.initials: J
authors.lastname: Yan
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wu
authors.forename: R Y
authors.initials: RY
authors.lastname: Cui
authors.forename: C L
authors.initials: CL
authors.lastname: Lu
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D006801:Humans; D017774:Long-Term Potentiation; D009473:Neuronal Plasticity / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology; D013569:Synapses / Q000502:physiology*
chemical_list: D002118:Calcium