[Linkage of allergic rhinitis with HLA-DRB alleles polymorphism].
OBJECTIVE
To investigate whether susceptibility or resistance to allergic rhinitis associated with HLA-DRB alleles.


METHODS
Using PCR-SSP (sequence-specific primer polymerase chain reaction), we tested the frequency distribution of HLA-DRB alleles in 41 patients with allergic rhinitis (AR) and 41 healthy controls from Beijing China.


RESULTS
The frequence of HLA-DRB1 * 0301.2 and HLA-DRB4 * 0101 was lower in AR than in controls (2.44% vs 17.07%, P < 0.05; 29.27% vs 51.22%, P < 0.05).


CONCLUSIONS
HLA-DRB1 * 0301.2 and HLA-DRB4 * 0101 alleles might confer protection against AR.
Xing
Z
Z
Department of Otolaryngology, People's Hospital, Beijing University, Beijing 100044.
Yu
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D000328:Adult; D000483:Alleles; D005260:Female; D008040:Genetic Linkage; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
D006684:HLA-DR Antigens