title: [Short-term course under beta blockers of clinical and echocardiographic parameters in mitral stenosis in sinus rhythm].
abstract: The purpose of this study is to evaluate the short-term benefit of a beta-blocker (atenolol) on clinical and echocardiographic parameters of patients presenting isolated or predominant mitral stenosis in sinus rhythm. It is a prospective study performed on 26 patients who have had a clinical and echocardiographic assessment before and 15 days after treatment by atenolol. After 15 days of beta-blocker treatment, there is a significant improvement of dyspnea (57.6% in class III or IV before beta-blockade versus 15.3% with atenolol; P = 0.001) and a significant decrease of the heart rate (83.3 +/- 15.2 versus 68.9 +/- 13.9; P = 0.001) and the diastolic blood pressure (8 mmHg +/- 1.3 versus 7.2 mmHg +/- 0.9; P = 0.01). The Doppler echocardiography shows a significant increase of the stroke volume calculated by the Doppler method (28.7 +/- 6.2 versus 38.6 +/- 9.7 mL; P = 0.04). There is an insignificant trend to an improvement of the left ventricular systolic function, an increase of cardiac output and the decrease of the mean transmitral gradient. The factors associated with the failure of beta-blocker treatment are: the right heart failure (P = 0.04) and the low diastolic blood pressure (P = 0.01). The beta-blockers could be a logical and effective treatment of patients with mitral stenosis waiting for balloon commissurotomy or surgery.
authors.affiliation: Clinique cardiologique, hôpital Aristide-le-Dantec, avenue Pasteur, BP 3001, Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Kane
authors.forename: S Y
authors.initials: SY
authors.lastname: Djamadar
authors.forename: A
authors.initials: A
authors.lastname: Affangla
authors.forename: I B
authors.initials: IB
authors.lastname: Diop
authors.forename: M
authors.initials: M
authors.lastname: Sarr
authors.forename: S A
authors.initials: SA
authors.lastname: Ba
authors.forename: S M
authors.initials: SM
authors.lastname: Diouf
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001262:Atenolol / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D000319:Adrenergic beta-Antagonists; D001262:Atenolol