title: Landau-Kleffner syndrome beginning with stuttering: case report.
abstract: Landau-Kleffner syndrome is marked by an acquired aphasia in children who have had normal language and motor development. A 3.5-year-old girl was referred to our clinic with stuttering. She was diagnosed as having benign myoclonic epilepsy of infancy at 3.5 months of age and treated with valproic acid. Her electroencephalogram (EEG) returned to normal at the end of the first year. The therapy was stopped after a 2-year seizure-free period. She started to stutter prominently 3 months after the discontinuation of antiepilepsy drugs. She had no verbal agnosia. Her EEG revealed multiple spike and wave discharges. She was diagnosed as having Landau-Kleffner syndrome. Her previous epilepsy history had contributed to her having obtained an EEG in the early period. We suggest that if a child with normal language function starts to stutter, Landau-Kleffner syndrome must be considered in the differential diagnosis.
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Sarenur
authors.initials: S
authors.lastname: Tütüncüoğlu
authors.forename: Gül
authors.initials: G
authors.lastname: Serdaroğlu
authors.forename: Bengü
authors.initials: B
authors.lastname: Kadioğlu
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D001037:Aphasia / Q000209:etiology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D013342:Stuttering / Q000209:etiology*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D016756:Immunoglobulins, Intravenous; D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone