title: Gene therapy in psychiatric disorders: too early, too complex?
abstract: Gene transfer strategies are being tested in a variety of animal models for psychiatric disorders. These promise to translate viral-mediated, non-viral and combinatorial techniques for delivery of transgenes into neuroanatomical and cell-type-specific therapeutic tools. However, these disorders involve complex functional neurocircuits and developmental aetiologies that may present even greater challenges than other neurological conditions.
authors.affiliation: University of Washington, Department of Psychiatry and Behavioral Sciences, Box 359911, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104-2499, USA. neumaier@u.washington.edu
authors.forename: John F
authors.initials: JF
authors.lastname: Neumaier
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics*; D016372:RNA, Antisense / Q000627:therapeutic use
chemical_list: D016372:RNA, Antisense