AML1 amplification in a child with acute lymphoblastic leukemia.
We report a case of de novo acute lymphoblastic leukemia with tandem amplification of the AML1 gene located in a chromosome marker that originated from chromosome 21 and a long event-free survival.
Alvarez
Yolanda
Y
Departamento de Biologi;a Animal, Biologi;a Vegetal y Ecologi;a, Unidad de Antropologi;a, Facultad de Ciencias, Universidad Autónoma de Barcelona, Barcelona, Spain. mariarosa.caballin@uab.es
Coll
M D
MD
Bastida
P
P
Ortega
J J
JJ
Caballín
M R
MR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D002648:Child; D002869:Chromosome Aberrations; D020223:Chromosome Painting; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics* / Q000648:ultrastructure; D050676:Core Binding Factor Alpha 2 Subunit; D003520:Cyclophosphamide / Q000008:administration & dosage; D004268:DNA-Binding Proteins / Q000235:genetics*; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D005784:Gene Amplification; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D011239:Prednisolone / Q000008:administration & dosage; D011518:Proto-Oncogene Proteins; D012074:Remission Induction; D014157:Transcription Factors / Q000235:genetics*; D014750:Vincristine / Q000008:administration & dosage
D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; D014157:Transcription Factors; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone; D001215:Asparaginase; D003630:Daunorubicin