Ribosome-lamella complex of leukemic cells in a patient with aggressive NK cell leukemia.
A 36-year-old male was admitted to the hospital with anemia and leukopenia. A bone marrow specimen revealed the proliferation of leukemic cells with flower-like nuclei observed in adult T-cell leukemia. The leukemic cells were positive for HLA-DR, CD2, CD7, and CD56. A diagnosis of aggressive NK cell leukemia was made, the patient was treated with induction chemotherapy and cord blood stem cell transplantation, and he is well now. Seen with electron microscopy, some leukemic cells had ribosome-lamella complexes (RLC). This is the first reported case of leukemic cells with flower-like nuclei seen with light microscopy and RLC seen with electron microscopy.
Hatsumi
Nahoko
N
Third Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan.
Saitoh
Takayuki
T
Yokohama
Akihiko
A
Uchiumi
Hideki
H
Matsushima
Takafumi
T
Tsukamoto
Norifumi
N
Nojima
Yoshihisa
Y
Karasawa
Masamitsu
M
Handa
Hiroshi
H
Ogawara
Hatsue
H
Murakami
Hirokazu
H
D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure; D007694:Killer Cells, Natural / Q000648:ultrastructure*; D015458:Leukemia, T-Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008297:Male; D009685:Nuclear Envelope / Q000648:ultrastructure; D012270:Ribosomes / Q000648:ultrastructure