title: Calcospherules associated with juvenile hyaline fibromatosis.
abstract: Juvenile hyaline fibromatosis is a rare autosomal recessive genodermatosis that manifests with 1 to 5 cm skin tumors, gingival hyperplasia, osteolytic bone lesions, and joint contractures. The skin tumors are most often located on the head and periarticular extremities. A case of juvenile hyaline fibromatosis with typical skin tumors that on biopsy exhibited basophilic calcospherules is presented. Although noted in a single case, these structures may be a novel, yet helpful, diagnostic marker.
authors.affiliation: Department of Dermatology and Dermatopathology Laboratory, University of California, Irvine, USA.
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Ko
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Barr
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005350:Fibroma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*