title: Influence of ethanolic extract of Tephrosia purpurea Linn. on mast cells and erythrocytes membrane integrity.
abstract: The ethanolic extract of T. purpurea Linn. was studied for its in vitro effect on rat mast cell degranulation and erythrocyte membrane integrity in vitro. The extract in concentration of 25-200 microg/ml showed a dose-dependant inhibition of rat mast cell degranulation induded by compound 48/80 and egg albumin. T. purpurea extract was found to inhibit haemolysis of erythrocytes induced by hypotonic solution but accelerated haemolysis induced by heat at a concentration of 100 microg/ml. The studies reveal that the ethanolic extract of T. purpurea may inhibit degranulation of mast cells by a mechanism other than membrane stabilization.
authors.affiliation: Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai 400 098, India.
authors.forename: A B
authors.initials: AB
authors.lastname: Gokhale
authors.forename: V J
authors.initials: VJ
authors.lastname: Dikshit
authors.forename: A S
authors.initials: AS
authors.lastname: Damre
authors.forename: K R
authors.initials: KR
authors.lastname: Kulkarni
authors.forename: M N
authors.initials: MN
authors.lastname: Saraf
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D000431:Ethanol / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D000431:Ethanol