title: [Acute experimental pancreatitis in the opossum. The role of early splenectomy in the inflammatory response]].
abstract: BACKGROUND
  The role of the Autonomous Nervous System in the immunologic and inflammatory response is still an issue of discussion. Furthermore, the physiopathologic mechanisms involved are still unknown. Acute pancreatitis (AP) does not escape this disconcert. In fact, like in every severe acute inflammatory process, its discontrol could be responsible of the high morbidity and mortality rates.
  
  
  OBJECTIVE
  To assess to which degree bilateral splanchnicectomy changes the course of acute inflammatory response in AP.
  
  
  METHODS
  Prospective research.
  
  
  RESULTS
  The following parameters were evaluated: red blood cell count, white blood cell count, calcium, glucemia, urea, aminase, lypase and liver enzymes. Macroscopy and microscopy views of the pancreas were also obtained. The leucocitary response was abolished, and the calcium levels dropped to a lesser degree.
  
  
  CONCLUSIONS
  Bilateral splanchnicectomy prior to unchaining AP had a beneficial effect, Its mechanism of action could have been through the disconnection of the respective reflex arches.
authors.affiliation: Secciòn Cirugìa Experimental, Servicio de Cirugìa General-Hospital Churruca-Visca.
authors.forename: H A
authors.initials: HA
authors.lastname: Garcìa
authors.forename: O
authors.initials: O
authors.lastname: Iodice
authors.forename: W M
authors.initials: WM
authors.lastname: Garcìa
authors.forename: Graciela
authors.initials: G
authors.lastname: Otero
authors.forename: L
authors.initials: L
authors.lastname: Uchiumi
authors.forename: J
authors.initials: J
authors.lastname: Affani
authors.forename: O M
authors.initials: OM
authors.lastname: Tiscornia
authors.forename: G
authors.initials: G
authors.lastname: Eufemio
authors.forename: Susana
authors.initials: S
authors.lastname: Sutera
authors.forename: Fernanda
authors.initials: F
authors.lastname: Sapin
authors.forename: P
authors.initials: P
authors.lastname: Cap
authors.forename: J
authors.initials: J
authors.lastname: Llaya Candiotti
authors.forename: A
authors.initials: A
authors.lastname: Maschietto
mesh_terms: D000208:Acute Disease; D000210:Acute-Phase Reaction; D000681:Amylases / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004906:Erythrocyte Count; D006400:Hematocrit; D007958:Leukocyte Count; D008049:Lipase / Q000097:blood; D009893:Opossums; D010179:Pancreas / Q000648:ultrastructure; D010195:Pancreatitis / Q000378:metabolism / Q000601:surgery*; D013156:Splenectomy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol; D008049:Lipase; D000681:Amylases; D002118:Calcium