title: Clonal development of a blastoid mantle cell lymphoma studied with comparative genomic hybridization.
abstract: A molecular cytogenetic study was performed on the diagnostic tumor sample and three relapses from a case with blastoid mantle cell lymphoma. The clonal relatedness of the tumors was demonstrated by identical rearrangements of the immunoglobulin heavy chain gene and was supported by results from comparative genomic hybridization analyses. All samples shared the common alterations of losses of 6q, 9p, and 11q and gains of 3q, 9q, 12p, and 13q, suggesting that they were relatively early events in the tumorigenesis. Relapse 1 also showed a loss of 8p, while relapses 2 and 3 had gained the X chromosome and 7p, in addition, relapse 3 displayed gains of chromosomes 3 and 20. Taken together, the findings suggest that relapses 2 and 3 developed from the diagnostic tumor sample, while relapse 1 represents a separate lineage of tumor progression originating directly from a postulated ancestral tumor cell carrying the common chromosomal alterations identified in all tumors.
authors.affiliation: Department of Molecular Medicine, Karolinska Hospital, SE-171 76, Stockholm, Sweden.
authors.forename: Emma
authors.initials: E
authors.lastname: Flordal
authors.forename: Mattias
authors.initials: M
authors.lastname: Berglund
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.forename: Martin
authors.initials: M
authors.lastname: Erlanson
authors.forename: Gunilla
authors.initials: G
authors.lastname: Enblad
authors.forename: Göran
authors.initials: G
authors.lastname: Roos
authors.forename: Catharina
authors.initials: C
authors.lastname: Larsson
authors.forename: Svetlana
authors.initials: S
authors.lastname: Lagercrantz
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization / Q000235:genetics*; D012008:Recurrence
chemical_list: D007143:Immunoglobulin Heavy Chains