[Morpho-functional changes of Mauthner neurons after treatment with neuropeptide kyotorphin ].
Influence of neuropeptide kyotorphin (L-thyrosyl-L-arginine) treatment on goldfish Mauthner cells was studied separately or in combination with prolonged natural stimulation of these neurons. The neuroprotective effect of this substance at both functional and ultrastructural levels was demonstrated. Possible mechanisms of kyotorphin action is discussed with regard to its modulating effect on intracellular calcium ion concentration.
Santalova
I M
IM
Laboratory of Neuronal Ultrastructure, RAS Institute of Theoretical and Experimental Biology, Educational Center of Biophysics and Physiology, Pushino State University.
Mavliutov
T A
TA
Moshkov
D A
DA
D000222:Adaptation, Physiological / Q000187:drug effects*; D000700:Analgesics / Q000633:toxicity*; D000818:Animals; D018871:Endoplasmic Reticulum, Smooth / Q000648:ultrastructure; D004723:Endorphins / Q000633:toxicity*; D006054:Goldfish / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D008845:Microinjections; D008854:Microscopy, Electron; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000648:ultrastructure*; D010812:Physical Stimulation; D012399:Rotation; D012965:Sodium Chloride / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D000700:Analgesics; D004723:Endorphins; C019448:kyotorphin; D012965:Sodium Chloride; D014700:Verapamil