Bringing classical embryology to C elegans gastrulation.
In a recent paper, Lee and Goldstein develop an explant assay that recapitulates key aspects of gastrulation in C elegans and permits classical embryological manipulations. The resulting detailed analysis of cell behavior will ultimately extend to broader issues, such as, whether morphogenesis can be described as the sum of single-cell events or if unique phenomena emerge at the multicellular level.
Dawes-Hoang
Rachel E
RE
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA.
Zallen
Jennifer A
JA
Wieschaus
Eric F
EF
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology*; D002454:Cell Differentiation; D002465:Cell Movement; D005775:Gastrula / Q000166:cytology*