title: Temperament in schizophrenia: a study of the tridimensional personality questionnaire (TPQ).
abstract: OBJECTIVE
  The aim of this study was to assess dimensions of temperament as defined by Cloninger's neurobiological model using the tridimensional personality questionnaire (TPQ) in a sample of consecutively recruited schizophrenic patients.
  
  
  METHODS
  We used the French version of the TPQ to compare 45 stable, euthymic schizophrenic patients with 126 controls with no personal or familial history of psychiatric disorder. After comparison of TPQ scores between groups, we also performed a multivariate analysis to avoid the confounding effects of age, gender, and alcohol and substance use disorder comorbidity.
  
  
  RESULTS
  Harm avoidance (HA) was higher in schizophrenic patients than in controls.
  
  
  CONCLUSIONS
  This replicates and extends the results of previous studies suggesting that schizophrenic patients have high HA and that HA might be a marker for underlying genetic vulnerability to schizophrenia.
authors.affiliation: Service de psychiatrie adulte, Hôpital Henri Mondor et Albert Chenevier, 40, rue de Mesly, AP-HP, 94000, Créteil, France.
authors.forename: Andrei
authors.initials: A
authors.lastname: Szöke
authors.forename: Franck
authors.initials: F
authors.lastname: Schürhoff
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ferhadian
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rouillon
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010554:Personality Disorders / Q000150:complications* / Q000175:diagnosis*; D010555:Personality Inventory; D012559:Schizophrenia / Q000150:complications*; D012720:Severity of Illness Index; D013694:Temperament