title: Tumor necrosis factor-induced signal transduction and left ventricular remodeling.
abstract: Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently, it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article will review the role of tumor necrosis factor-induced signal transduction and the process of left ventricular remodeling.
authors.affiliation: Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, Houston Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D032383:Myocytes, Cardiac / Q000378:metabolism; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D020257:Ventricular Remodeling
chemical_list: D014409:Tumor Necrosis Factor-alpha