title: [Tissue factor (TF) and inhibitor (TFPI) concentrations in patients with urinary tract tumors and haematological malignancies].
abstract: The aim of study was to evaluate TF activity and TFPI concentration in patients with haematological malignancies and urinary tract tumors. TFPI concentration and activity and TF concentration were measured in 20 patients suffering from acute myeloblastic leukaemia (AML), 21 patients with chronic myelogenous leukaemia (CML), 17 patients with chronic lymphatic leukaemia (CLL), 16 patients with multiple myeloma (MM) and 65 healthy adults. TFPI and TF concentrations were measured also in patients with renal cell carcinoma (n = 12) and bladder cancer (n = 17) and patients with benign prostatic hyperplasia (BPH) (n = 15). Patients with AML, CML, CLL, and cancer revealed elevated TFPI concentrations. Patients with AML, CML, CLL, MM showed decreased TFPI activity. However TFPI concentration correlated inversely with TFPI activity only in the AML group. No significant changes were observed in TF concentrations in all investigated groups.
authors.affiliation: Klinika Hematologii AM w Białymstoku, Regionalne Centrum Krwiodawstwa i Krwiolecznictwa w Białymstoku.
authors.forename: Piotr
authors.initials: P
authors.lastname: Radziwon
authors.forename: Joachim F
authors.initials: JF
authors.lastname: Schenk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mazgajska
authors.forename: Barbara
authors.initials: B
authors.lastname: Boczkowska-Radziwon
authors.forename: Marzenna
authors.initials: M
authors.lastname: Galar
authors.forename: Janusz
authors.initials: J
authors.lastname: Kłoczko
authors.forename: Marek Z
authors.initials: MZ
authors.lastname: Wojtukiewicz
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood; D007938:Leukemia / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009101:Multiple Myeloma / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*; D013925:Thromboplastin / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000097:blood; D014571:Urologic Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin