Oxidative stress, nitric oxide, and vascular disease.
Superoxide (O2-) is a key risk factor for cardiovascular disease (CVD), including atherogenesis, reperfusion injury, angina, restenosis following balloon angioplasty, and vein graft failure. Axiomatically, O2- reacts with nitric oxide (NO) to form peroxynitrite (ONOO) resulting in a depletion of endogenous vascular NO, which is now firmly associated with CVD. Furthermore, risk factors for CVD, in particular diabetes mellitus (DM), dyslipidemia, and hyperhomocysteinemia are all associated with oxidative stress OS. Antioxidant therapies, including the gene transfer of antioxidant enzymes, are potentially valuable in the treatment of CVD.
Jeremy
Jamie Y
JY
Bristol Heart Institute, The University of Bristol, United Kingdom. j.y.jeremy@bristol.ac.uk
Yim
Anthony P
AP
Wan
Song
S
Angelini
Gianni D
GD
D017209:Apoptosis / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism* / Q000503:physiopathology*; D014661:Vasoconstriction / Q000502:physiology
D013481:Superoxides; D009569:Nitric Oxide