title: Efficacy of inhaled corticosteroids administered once daily for asthma.
abstract: Inhaled corticosteroids (ICS) are the most effective medications for the long term control of asthma. When first used in asthma management, these drugs were scheduled 3- or 4-times daily, but by the late 1980s, it became clear that most patients respond excellently to twice-daily dosing. Numerous recent double-blind, randomized trials have demonstrated the efficacy of once-daily ICS in the management of pediatric and adult asthma. Once-daily dose ICS is most appropriate for patients' mild persistent asthma, and will be effective for many patients with moderate persistent asthma. Some studies suggest late afternoon/early evening dosing is preferable to single daily dosing in the morning.
authors.affiliation: Department of Clinical Pharmacy, University of Tennessee, 26 S. Dunlap, Memphis, TN 38163, USA. tself@utmem.edu
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Self
authors.forename: Roya M
authors.initials: RM
authors.lastname: Sameri
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000145:classification; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001249:Asthma / Q000145:classification / Q000188:drug therapy* / Q000517:prevention & control; D004513:Education, Pharmacy, Continuing; D006801:Humans; D011278:Pregnanes / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D012449:Safety; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D011278:Pregnanes