title: Utility of antiepileptic drug monitoring in the pediatric emergency department.
abstract: Convulsive disorders are common in the pediatric age group, and measurement of serum concentration of an antiepileptic drug (AED) is frequently ordered for epileptic patients in the emergency department (ED). The objective of this study was to develop a better understanding of the indications for, and consequences of, monitoring AED serum concentrations in the pediatric ED. Charts of 116 patients who visited the ED and were tested for blood levels of AED were retrospectively reviewed. Main outcome measures were number and percentage of levels outside the therapeutic range, discontinuation of an AED or introduction of a new one, dosage modifications, and admission to hospital. Two pediatricians and a pediatric neurologist aware only of patients' age, weight, diagnosis, history, clinical presentation, and drug details reviewed each case and on the basis of predetermined criteria decided whether measurement of AED was indicated. Mean age (+/- SD) of the study population was 7 +/- 5 years (range, 2 months-17 years). Forty-two patients (36%) were on monotherapy, and 74 (64%) were on polytherapy. Sixty-eight patients (59%) presented with increased seizure frequency, 7 (6%) with status epilepticus, and 13 (11%) with suspected AED toxicity. The remainder of the children presented with problems unrelated to epilepsy. No significant difference was found between patients with AED levels within the therapeutic range and those with levels outside it in the proportion of children needing dosage change, change in medication, or hospital admission (P = 0.5, 0.8, and 0.8, respectively). None of the patients presenting with status epilepticus and only 15% of those with increased seizure activity had subtherapeutic levels. Review of the cases suggested that measuring serum AED level was not indicated in 57 (49.1%) patients. In the pediatric ED, abnormal AED levels do not correlate with clinical management. Before ordering tests, physicians should consider whether their results would alter patient treatment.
authors.affiliation: Division of Emergency Services, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Eran
authors.initials: E
authors.lastname: Kozer
authors.forename: Dennis
authors.initials: D
authors.lastname: Scolnik
authors.forename: Whitty M
authors.initials: WM
authors.lastname: Agamata
authors.forename: Shelly K
authors.initials: SK
authors.lastname: Weiss
authors.forename: Zulfikaral H
authors.initials: ZH
authors.lastname: Verjee
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000097:blood*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D016903:Drug Monitoring / Q000379:methods* / Q000706:statistics & numerical data; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants