The metabolic syndrome: a tug-of-war with no winner.
The metabolic syndrome may be viewed as a state of insulin-counterregulatory overdrive: counterregulatory hormones and fatty acids chronically duel with insulin, causing a cascade of biochemical interactions resulting in insulin resistance, hypertension, and dyslipidemia. Even before beta cells fail and type 2 diabetes ensues, the deadly quartet is quietly rehearsing.
Brotman
Daniel J
DJ
Girod
John P
JP
D015444:Exercise / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D005247:Feeding Behavior / Q000502:physiology; D005938:Glucocorticoids / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D007515:Islets of Langerhans / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism
D005227:Fatty Acids; D005938:Glucocorticoids; D007328:Insulin; D011994:Recombinant Proteins; D019382:Human Growth Hormone