Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report.
The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei. Metastases occurred 4 months after incomplete resection with prior therapeutic embolization. The recurrent tumor in turn displayed anaplastic features and an increased Ki-67 labeling index. Genetic alterations in such morphologically benign meningiomas have been implicated in the malignant development and progression of these tumors.
Cerdá-Nicolás
Miguel
M
Department of Pathology, University Clinic Hospital of Valencia, University of Valencia, Spain. jose.m.cerda@uv.es
Lopez-Gines
Concha
C
Perez-Bacete
Miguel
M
Roldan
Pedro
P
Talamantes
Fernando
F
Barberá
José
J
D000368:Aged; D020732:Cytogenetic Analysis; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D013160:Splenic Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery