title: [Determination of benproperine phosphate tablets by high performance liquid chromatography].
abstract: A reversed-phase HPLC method for the determination of benproperine phosphate tablets is reported. The chromatographic conditions were Hypersil-C18 column(5 microns, 4.6 mm i.d. x 150 mm) at 35 degrees C, mobile phase of methanol-water-glacial acetic acid-triethylamine(60:35:5:0.1, V/V) with a flow rate of 0.9 mL/min and UV detection at 270 nm. Cortisone acetate was selected as the internal standard. The linear relationship of calibration curve was good in the range of 9.96 mg/L-49.8 mg/L(r = 0.9998). The average recovery and RSD were 99.91%(n = 5) and 0.43% respectively. The total time of analysis for a run was within 7 min. The method is simple, sensitive, rapid and accurate.
authors.affiliation: Changchun Institute for Drug Control, Changchun 130061, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Yang
authors.forename: X Y
authors.initials: XY
authors.lastname: Yang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003348:Cortisone / Q000031:analogs & derivatives*; D005100:Expectorants / Q000032:analysis*; D010880:Piperidines / Q000032:analysis*
chemical_list: D005100:Expectorants; D010880:Piperidines; D003348:Cortisone