title: Arthropathy in juvenile hemochromatosis.
abstract: OBJECTIVE
  To evaluate whether arthropathy is associated with juvenile hemochromatosis and, if so, to assess the relationship between this feature and other clinical features of the disease.
  
  
  METHODS
  Clinical, laboratory, and radiologic evidence of arthropathy was studied in 8 Greek patients with genetically proven juvenile hemochromatosis. Osteopenia and osteoporosis were assessed by bone mineral density measurement.
  
  
  RESULTS
  Seven of the 8 patients had articular manifestations. The main affected joint was the metacarpophalangeal joint, and the arthritis was progressive independent of phlebotomy therapy. Osteopenia was observed in 2 patients, and osteoporosis in 2 patients.
  
  
  CONCLUSIONS
  Arthropathy may be present in patients with juvenile hemochromatosis, with features similar to those found in patients with hemochromatosis type 1.
authors.affiliation: University of Athens Medical School, Athens, Greece. georgi@otenet.gr
authors.forename: George
authors.initials: G
authors.lastname: Vaiopoulos
authors.forename: George
authors.initials: G
authors.lastname: Papanikolaou
authors.forename: Marianna
authors.initials: M
authors.lastname: Politou
authors.forename: Iyad
authors.initials: I
authors.lastname: Jibreel
authors.forename: Nikos
authors.initials: N
authors.lastname: Sakellaropoulos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Loukopoulos
mesh_terms: D000328:Adult; D017668:Age of Onset; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005293:Ferritins / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D006432:Hemochromatosis / Q000150:complications*; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography
chemical_list: D012739:Gonadal Steroid Hormones; D005293:Ferritins