[Effects of chitin and chitosan on degradation of DL-polylactide in vitro].
The authors assessed the variations of pH-values of the physiological saline used for in vitro degradation tests of DL-Polylactide (DL-PLA)/chitin and DL-PLA/chitosan composites and DL-PLA. The weight-loss rations, the appearance and morphology of the tested specimens, and the molecular weights of DL-PLA in composites and pure DL-PLA were alse investigated. The results showed that both chitin and chitosan had significant inhibitory effects on the degradation of DL-PLA, and the effect of chitosan was stronger than that of chitin. A discussion on the mechanism of such inhibition is presented.
Liao
K
K
Institute of Polymer Science, Zhongshan University, Guangzhou 510275.
Tang
F
F
Luo
L
L
Lu
Z
Z
Huang
H
H
D001672:Biocompatible Materials; D001673:Biodegradation, Environmental / Q000187:drug effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism*
D001672:Biocompatible Materials; D011091:Polyesters; D002686:Chitin; C033616:poly(lactide)