Serum concentration of TNF-alpha and IL-1 beta in patients with chronic hepatitis C treated with interferon alpha--a preliminary report.
The aim of the study was to evaluate the concentration of TNF-alpha and IL-1 beta in 14 chronic hepatitis C patients during interferon treatment in a correlation with biochemical indicators of hepatic cell damage, AspAT and ALAT activity. The study included the sera obtained every month (10-12 measurements) during 48-week therapy. IL-1 beta and TNF-alpha concentrations were determined by ELISA method. Statistic analysis were performed with AnStat program. The wide range of IL-1 beta and TNF-alpha concentration values may prove a differentiated response to immunomodulating treatment with INF-alpha. Concentrations of TNF-alpha, IL-1 beta, show decreasing tendency during therapy. A positive correlation between proinflammatory cytokines (IL-1 beta and TNF-alpha), ALAT and AspAT indicates the role of these cytokines and their relation to a necrotic-inflammatory process demonstrated by aminotransferases concentration.
Zajkowska
Joanna M
JM
Department of Infectious Diseases and Neuroinfection, Medical Academy of Białystok, Białystok, Poland. zajkowsk@kki.pl
Hermanowska-Szpakowicz
Teresa
T
Pancewicz
Sławomir A
SA
Kondrusik
Maciej
M
Swierzbińska
Renata
R
Grygorczuk
Sambor
S
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D007375:Interleukin-1 / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D011994:Recombinant Proteins; D012016:Reference Values; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015415:Biomarkers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007375:Interleukin-1; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha