title: Hepatoprotective and antihyperliposis activities of in vitro cultured Anoectochilus formosanus.
abstract: The pharmacological effects of an aqueous extract of the whole plants of in vitro cultured Anoectochilus formosanus were investigated experimentally for hepatoprotective and antihyperliposis activities. The extract showed significant antihepatotoxic activity against carbon tetrachloride induced cytotoxicity in primary cultured rat hepatocytes. In an assay for antihyperliposis using aurothioglucose-induced obese mice, the extract suppressed significantly the increase in the weights of body and liver, ameliorated triglyceride levels in the liver and serum, and also significantly reduced the deposition of adipose tissue.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582 , Japan.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Du
authors.forename: Ning-Yi
authors.initials: NY
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugiura
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Shoyama
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006051:Aurothioglucose; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D022781:Hepatocytes / Q000187:drug effects; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029595:Orchidaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D006051:Aurothioglucose; D002251:Carbon Tetrachloride