title: Acute fatty liver of pregnancy: a report of two cases.
abstract: Acute fatty liver of pregnancy is an uncommon, potentially fatal disorder. Between 1998 and 2000, two patients with acute fatty liver of pregnancy presented at the Christian Medical College Hospital, Vellore. Both patients were in the thirty-sixth week of pregnancy. jaundice and encephalopathy were the predominant symptoms. Both the mothers died after they delivered a stillborn Infant each. The maternal deaths were due to multiorgan failure and/or postpartum haemorrhage and sepsis. The route of delivery was vaginal in both the patients. Extrahepatic and metabolic complications in both cases Included renal failure, sepsis, hypoglycaemia, disseminated intravascular coagulation and gastrointestinal bleeding. Liver biopsy done in both patients was consistent with the diagnosis of acute fatty liver of pregnancy. To the best of our knowledge, this is the first report from India on acute fatty liver of pregnancy.
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India
authors.forename: G
authors.initials: G
authors.lastname: Loganathan
authors.forename: C E
authors.initials: CE
authors.lastname: Eapen
authors.forename: Rachel G
authors.initials: RG
authors.lastname: Chandy
authors.forename: Padmini
authors.initials: P
authors.lastname: Jasper
authors.forename: Matthews
authors.initials: M
authors.lastname: Mathai
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Seshadri
authors.forename: Banumathi
authors.initials: B
authors.lastname: Ramakrishna
authors.forename: Atanu Kumar
authors.initials: AK
authors.lastname: Jana
authors.forename: George
authors.initials: G
authors.lastname: John
authors.forename: George M
authors.initials: GM
authors.lastname: Chandy
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005234:Fatty Liver / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*