title: [Analysis and stability study on nimotop injections by RP-HPLC].
abstract: A method was developed by using reversed-phase high performance liquid chromatography (HPLC) to analyze nimotop injections. Methyltestosterone was used as an internal standard. The separation was performed on a YWG C18 column with mobile phase of V (methanol):V (water) = 65:35 and detected at 238 nm. The linear concentration range of this method was 5.98 mumol/L-299.0 mumol/L. This method was simple, rapid and has been used to study the stability of nimotop injections. The experimental results showed that the nimotop was stable at higher temperature (50 degrees C) but unstable under light. Nimotop injection should be kept away from light.
authors.affiliation: 175th Hospital PLA, Zhangzhou 363000, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Hu
authors.forename: Q H
authors.initials: QH
authors.lastname: Tang
authors.forename: Q Y
authors.initials: QY
authors.lastname: Du
mesh_terms: D002121:Calcium Channel Blockers / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D009553:Nimodipine / Q000032:analysis*
chemical_list: D002121:Calcium Channel Blockers; D009553:Nimodipine