Granuloma annulare-like infiltrates with concomitant cutaneous involvement by B-cell non-Hodgkin's lymphoma: report of a case.
Granulomatous infiltrates, including granuloma annulare-like changes, in patients with T-cell non-Hodgkin's lymphoma and Hodgkin's disease are well described but are exceedingly uncommon in B-cell non-Hodgkin's lymphoma. Herein, we describe a 73-year-old male with a 10-year history of B-cell chronic lymphocytic leukemia who developed erythematous annular plaques symmetrically on his upper extremities. Biopsies of these lesions revealed both granuloma annulare-like areas, in conjunction with nodular atypical lymphoid infiltrates consistent with secondary involvement by B-cell chronic lymphocytic leukemia. To our knowledge, this is the first report of cutaneous lesions resembling granuloma annulare with concomitant involvement by B-cell chronic lymphocytic leukemia. Awareness of this association may prevent nonrecognition of a neoplastic B-cell infiltrate in a granuloma annulare-like process.
Fullen
Douglas R
DR
Department of Pathology, University of Michigan Hospitals, University of Michigan, Ann Arbor, 48109-0602, USA. dfullen@umich.edu
Jacobson
Sarah N
SN
Valdez
Riccardo
R
Novice
Fred M
FM
Lowe
Lori
L
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016460:Granuloma Annulare / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D000970:Antineoplastic Agents