title: Effects of electroconvulsive therapy on regional cerebral blood flow measured by 99mtechnetium HMPAO SPECT.
abstract: Decreased cerebral blood flow is documented in depression. In this study, 15 patients were studied with 99mTc-HMPAO SPECT before and after a course of electroconvulsive therapy (ECT). Improvement in frontal and temporal hypoperfusion was seen only in those patients who responded to ECT. Cerebral hypoperfusion may be a state-dependent marker in depressive illness.
authors.affiliation: Division of Nuclear Medicine, Johannesburg Hospital, Private Bag x39, Johannesburg 2000, South Africa. 084mboy@chiron.wits.ac.za
authors.forename: Mboyo Di Tamba
authors.initials: MD
authors.lastname: Vangu
authors.forename: Jan Daniel
authors.initials: JD
authors.lastname: Esser
authors.forename: Ivan Harry
authors.initials: IH
authors.lastname: Boyd
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime