Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids.
Long-chain PUFA play an important role in early human neurodevelopment. Significant inverse correlations were reported between values of trans isomeric and long-chain PUFA in plasma lipids of preterm infants and children aged 1-15 yr as well as in venous cord blood lipids of full-term infants. Here we report FA compositional data of cord blood vessel wall lipids in 308 healthy, full-term infants (gestational age: 39.7 +/- 1.2 wk, birth weight: 3528 +/- 429 g, mean +/- SD). The median (interquartile range) of the sum of 18-carbon trans FA was 0.22 (0.13) % w/w in umbilical artery and 0.16 (0.10) % w/w in umbilical vein lipids. Nonparametric correlation analysis showed significant inverse correlations between the sum of 18-carbon trans FA and both arachidonic acid and DHA in artery (r = -0.38, P < 0.01, and r = -0.20, P < 0.01) and vein (r = -0.36, P < 0.01, and -0.17, P < 0.01) wall lipids. In addition, the sum of 18-carbon trans FA was significantly positively correlated to Mead acid, a general indicator of EFA deficiency, in both artery (r = +0.35, P < 0.01) and vein (r = +0.31, P< 0.01) wall lipids. The present results obtained in a large group of full-term infants suggest that maternal trans FA intake is inversely associated with long-chain PUFA status of the infant at birth.
Decsi
Tamás
T
Department of Paediatrics, University of Pécs, H-7623 Pécs, Hungary. tamas.decsi@aok.pte.hu
Boehm
Günther
G
Tjoonk
H M Ria
HM
Molnár
Szilárd
S
Dijck-Brouwer
D A Janneke
DA
Hadders-Algra
Mijna
M
Martini
Ingrid A
IA
Muskiet
Frits A J
FA
Boersma
E Rudy
ER
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis*; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007536:Isomerism; D008297:Male; D011247:Pregnancy; D013229:Stearic Acids / Q000032:analysis* / Q000737:chemistry*; D014469:Umbilical Arteries / Q000737:chemistry* / Q000166:cytology*; D014471:Umbilical Veins / Q000737:chemistry* / Q000166:cytology*; D014481:United States
D013229:Stearic Acids; D016718:Arachidonic Acid; C031183:stearic acid; D015126:8,11,14-Eicosatrienoic Acid; C010944:mead acid