title: Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity.
abstract: Acanthosis nigricans (AN) is a cutaneous marker of various underlying systemic conditions. To date, no satisfactory topical therapy for this cutaneous disorder has been described. The following is a report of the successful use of a combination of 12% ammonium lactate cream and 0.05% tretinoin cream to treat AN associated with obesity.
authors.affiliation: New York-Presbyterian University Hospital of Columbia, Cornell Department of Dermatology, New York Weill-Cornell Center, New York, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Blobstein
mesh_terms: D000052:Acanthosis Nigricans / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D000287:Administration, Topical; D000293:Adolescent; D004359:Drug Therapy, Combination; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D019344:Lactic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D009765:Obesity / Q000150:complications*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage* / Q000627:therapeutic use*; D014212:Tretinoin / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D007641:Keratolytic Agents; D000644:Quaternary Ammonium Compounds; D019344:Lactic Acid; D014212:Tretinoin