A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report.
An immunocompetent 29-year-old male presented with an embolic stroke from an unusual primary cardiac lymphoma. The cardiac lesion consisted of a polypoid, left atrial, mural fibrin thrombus with anaplastic tumor cells lining the surface of the clot. Histologic, immunophenotypic, and molecular characterizations were consistent with a diagnosis of CD30+ large B-cell lymphoma with anaplastic cytology. While tumor emboli from invasive primary cardiac lymphomas have been reported, this noninvasive fibrin thrombus-associated lymphoma appears to be unique and previously unreported.
Quigley
Michael M
MM
Department of Pathology, Division of Cardiology, Naval Medical Center, San Diego, CA 92134, USA. mmquigley@nmcsd.med.navy.mil
Schwartzman
Eric
E
Boswell
Pamela D
PD
Christensen
Rebecca L
RL
Gleason
Lisa A
LA
Sharpe
Robert W
RW
D'Amato
Thomas A
TA
D000328:Adult; D003937:Diagnosis, Differential; D005337:Fibrin / Q000032:analysis; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D020766:Intracranial Embolism / Q000209:etiology*; D017730:Ki-1 Antigen / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009232:Myxoma; D010976:Platelet Count; D020521:Stroke / Q000209:etiology*; D014463:Ultrasonography
D017730:Ki-1 Antigen; D005337:Fibrin