title: Enhanced effects of central angiotensin II on cardiovascular and drinking responses in inbred polydipsic (STR/N) mice.
abstract: STR/N, an inbred strain of mice, is known to exhibit extreme polydipsia and polyuria. The objective of this study was to investigate the possible reasons for polydipsia. First, comparisons were made between STR/N mice and control mice from the Institute of Cancer Research (ICR) concerning daily drinking, urinary excretion, and basal cardiovascular function. Then, since angiotensin II (ANG II) is a potent stimulus for drinking behavior, we investigated the effects of intracerebroventricular (i.c.v.) administration of ANG II on cardiovascular and water intake responses. Daily water intake, food intake, urinary volume, and urinary electrolytes (Na and K) excretion were larger in STR/N mice than in ICR mice, and the basal blood pressure was significantly lower in STR/N mice than in ICR mice. The i.c.v. administration of ANG II (10 pmol/per mouse) resulted in increased mean arterial blood pressure (MAP) and water intake in both STR/N and ICR mice, but the changes in MAP were significantly larger in STR/N mice than in ICR mice. These results suggest that polydipsia in STR/N mice is at least partially attributable to high sensitivity of central ANG II receptors and low MAP.
authors.affiliation: Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan.
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Chu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kato
authors.forename: Takato
authors.initials: T
authors.lastname: Kunitake
authors.forename: Shoichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: De-Lai
authors.initials: DL
authors.lastname: Qiu
authors.forename: Youichi
authors.initials: Y
authors.lastname: Ueta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kannan
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D007276:Injections, Intraventricular; D051379:Mice; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains; D011141:Polyuria / Q000235:genetics; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
chemical_list: D000804:Angiotensin II; D012964:Sodium; D011188:Potassium