[Expression of platelet-derived growth factor-b and transforming growth factor-beta 1 in the alveolar macrophages of allergic rats].
OBJECTIVE
To investigate the role of alveolar macrophages in airway remodeling in asthma.


METHODS
Sixteen Wistar rats were divided into two groups: control group and asthmatic group. The expressions of platelet-derived growth factor-b (PDGF-b) and transforming growth factor-beta. (TGF-beta 1) in the alveolar macrophages of allergic rats were detected by immunohistochemistry and in situ hybridization.


RESULTS
The expression of TGF-beta 1 in alveolar macrophages in allergic group was increased in both protein level (P < 0.05) and TGF-beta 1 mRNA(P < 0.01); but the expression of PDGF-b had no difference between the two groups.


CONCLUSIONS
The alveolar macrophages may involve in the airway remodeling of asthma.
Pan
P H
PH
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen
Q L
QL
Wu
E S
ES
D000818:Animals; D001249:Asthma / Q000378:metabolism*; D005260:Female; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D020574:Proto-Oncogene Proteins c-sis / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics
D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta