Adaptors as central mediators of signal transduction in immune cells.
Adaptors are molecular scaffolds that recruit effectors, which are critical for immune cell activation. Recent work has underscored the requirement for adaptors in propagating stimulatory signals as well as their ability to inhibit immune cell function. The mechanisms by which adaptors function rely not only on the intermolecular interactions they mediate, but also on where they are localized within the cell. The use of sophisticated genetic, biochemical, cellular and imaging approaches has provided important new insights into the biology of adaptor protein function. Here we focus on T lymphocytes as a model to illustrate the critical roles adaptors play as regulators of cellular activation.
Jordan
Martha S
MS
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA.
Singer
Andrew L
AL
Koretzky
Gary A
GA
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport / Q000737:chemistry / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008565:Membrane Proteins; D051379:Mice; D018448:Models, Immunological; D010750:Phosphoproteins / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; C110810:LAT protein, human; C491734:Lat protein, mouse; D008565:Membrane Proteins; D010750:Phosphoproteins; C092947:SLP-76 signal Transducing adaptor proteins