[The effect of HJ-1 NO--HFJV respirator on treating pulmonary edema caused by seawater drowning].
The study was to observe the therapeutic effect of HJ-1 NO--HFJV respirator on treating pulmonary edema caused by seawater drowning. Seawater was infused into the rabbit's lung to establish the animal model of pulmonary edema caused by seawater drowning(PE-SWD). Then the animals were divided into three groups: simple PE-SWD model as control group, treat group(animal model treated with HFJV respirator and four medicines) and HFJV respiratior plus NO group. Pao2, Sao2 and pH were measured by the blood-gas analyzer. The survival time and seawater drowing-respiratiory distress syndrom(SW-RDS) were observed. The results showed that Pao2, Sao2 in NO group were remarkably higher than that of PE-SWD control group, and the survival time was longer than that of medicine treated group and the incidence of SW-RDS decreased to zero. We assume that HJ-1 NO-HFJV respirator is efficient on treating pulmonary edema.
Fan
Yanrong
Y
Institute of Molecular Medicine, Nanjing Military Medical College, Nanjing 210099.
Dong
Wendu
W
He
Jingjin
J
Du
Li
L
Xu
Genxing
G
Liu
Xinjuan
X
Pei
Yun
Y
Fu
Gengfeng
G
Ma
Guohua
G
D000818:Animals; D004195:Disease Models, Animal; D006611:High-Frequency Jet Ventilation / Q000295:instrumentation; D015701:Near Drowning / Q000150:complications*; D009569:Nitric Oxide / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000209:etiology / Q000628:therapy*; D011817:Rabbits
D009569:Nitric Oxide