title: [Pyoderma gangrenosum--positive effect of cyclosporin A therapy ].
abstract: Although pyoderma gangrenosum is a disorder known since over 70 years, it still remains a diagnostic and therapeutic problem. We describe three subjects with pyoderma gangrenosum; two were females, one was male, one case was associated with colitis ulcerosa, two were without any related disorders. Histopathologic examinations supported the diagnosis in all cases. In spite of intensive topical and systemic treatment with corticosteroids, Dapsone, Clofazimine, no sufficient effects were achieved. Cyclosporin A introduced in the dose of 5 mg/kg/d resulted in dramatic response and complete remission. Serum CyA levels, biochemical parameters of liver and kidney function, blood pressure were monitored during the therapy. No adverse events due to Cyclosporin A were observed.
authors.affiliation: Katedra i Klinika Dermatologii Sl. AM w Katowicach.
authors.forename: Ewa
authors.initials: E
authors.lastname: Krauze
authors.forename: Anna
authors.initials: A
authors.lastname: Lis
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kamińska-Budzińska
authors.forename: Mariola
authors.initials: M
authors.lastname: Wygledowska-Kania
authors.forename: Ewa
authors.initials: E
authors.lastname: Pierzchała
authors.forename: Ligia
authors.initials: L
authors.lastname: Brzezińska-Wcisło
mesh_terms: D000287:Administration, Topical; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine