Femoral central venous catheter-associated deep venous thrombosis in children with diabetic ketoacidosis.
OBJECTIVE
To describe the incidence of clinical deep venous thrombosis associated with femoral central venous catheters (CVC-DVT) in children with diabetic ketoacidosis (DKA).


METHODS
Retrospective case-matched control series.


METHODS
Pediatric intensive care units of two university-affiliated hospitals.


METHODS
All eight pediatric DKA patients with femoral central venous catheters between 1998 and 2001, and 16 age-matched control patients with femoral central venous catheters and circulatory shock.


METHODS
None.


RESULTS
The records of all children with DKA and the control patients were reviewed. CVC-DVT was defined as persistent ipsilateral leg swelling after removal of a femoral central venous catheter. Control patients with coagulopathies, thrombocytopenia, cancer, and hyperglycemia were excluded. Four of eight patients with DKA developed CVC-DVT compared with none of the 16 control patients (p = .007, Fisher's exact test). All four patients with DKA and CVC-DVT were <3 yrs old. Doppler ultrasound examination was performed on three of the four patients with clinical CVC-DVT, confirming the diagnosis in each case.


CONCLUSIONS
This study suggests that young children with DKA have an increased incidence of clinical DVT associated with the placement of femoral central venous catheters.
Gutierrez
Juan A
JA
Department of Pediatrics, Steele Memorial Children's Research Center, University of Arizona College of Medicine, Tucson, USA.
Bagatell
Rochelle
R
Samson
Meredith P
MP
Theodorou
Andreas A
AA
Berg
Robert A
RA
D000293:Adolescent; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000628:therapy*; D005260:Female; D005268:Femoral Vein; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D016555:Matched-Pair Analysis; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000209:etiology*