Memory traces unbound.
The idea that new memories are initially 'labile' and sensitive to disruption before becoming permanently stored in the wiring of the brain has been dogma for >100 years. Recently, we have revisited the hypothesis that reactivation of a consolidated memory can return it to a labile, sensitive state - in which it can be modified, strengthened, changed or even erased! The data generated from some of the best-described paradigms in memory research, in conjunction with powerful neurobiological technologies, have provided striking support for a very dynamic neurobiological basis of memory, which is beginning to overturn the old dogma.
Nader
Karim
K
Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1. nader@hebb.psych.mcgill.ca
D000818:Animals; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D008959:Models, Neurological; D008960:Models, Psychological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D012313:RNA / Q000235:genetics / Q000502:physiology*; D012054:Reinforcement, Psychology
D009419:Nerve Tissue Proteins; D012313:RNA