A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis.
Xerotic skin is a pattern of reaction to a variety of disorders (eg, winter xerosis, hereditary ichthyosis) with abnormalities of desquamation in common. The trial described in this article was a double-blind randomized-comparison clinical trial investigating the effect of pure lanolin versus ammonium lactate 12% cream in treating moderate to severe foot xerosis. Xerosis was clinically assessed at baseline visit, and designated sites were reevaluated after 1, 2, and 4 weeks of therapy. Ninety-two patients were enrolled; 41 of these were excluded from analysis (25 were lost to follow-up, 8 were noncompliant, 1 was discharged from study because of an adverse event after visit 1, and 7 were noncompliant after visit 2). Although there was significant improvement in xerosis scores for both treatment groups after 2 and 4 weeks of treatment, no differences were statistically significant. Used twice daily for 4 weeks, pure lanolin and ammonium lactate cream were both effective in treating moderate to severe xerosis.
Jennings
Maureen B
MB
New York College of Podiatric Medicine, 1800 Park Ave, New York, NY 10035, USA. mjennin@nycpm.edu
Alfieri
Donna M
DM
Parker
Eunice Ramsey
ER
Jackman
Lorraine
L
Goodwin
Susan
S
Lesczczynski
Christine
C
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy*; D019344:Lactic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007809:Lanolin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013997:Time Factors
D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; D019344:Lactic Acid; D007809:Lanolin