[Determination and stability tests of triclosan in disinfectants].
A method has been developed for the determination of triclosan in antibacterial detergent by RP-HPLC equipped with a diode-array detector. A Kromasil C18 column (200 mm x 4.6 mm i.d., 7 microns) was used with a mobile phase of methanol-acetonitrile-water (40:40:20, volume ratio) containing 0.02 mol/L KH2PO4 at pH 2.7 and UV detection at 280 nm. The samples were dissolved with the mobile phase by ultrasonic method. The recoveries of triclosan were from 94.2% to 102.2% and the RSDs were from 2.2% to 3.0%. The method is simple, rapid, accurate and reproducible. The concentrations of standards and samples did not change evidently after storage at 54 degrees C for 14 d and at 37 degrees C for 90 d. The results showed that triclosan has a good stability.
Li
Jie
J
Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Zhao
Hai-yan
HY
Peng
Guo-ke
GK
Tian
Pei-yao
PY
Li
Chang-qing
CQ
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D015203:Reproducibility of Results; D014260:Triclosan / Q000032:analysis*
D000891:Anti-Infective Agents, Local; D014260:Triclosan