Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.
BACKGROUND
The deleted GSTT1 and GSTM1 genotypes (null genotypes) resulting in loss of transferase activity are found in 10-20% and 50-60% of the population, respectively.


METHODS
The GSTT1- and GSTM1-dependent risk for sporadic colorectal cancer (CRC) was studied in 247 incident CRC cases and 296 hospital-based controls.


RESULTS
The GSTT1-null genotype was found to be 1.5 times more prevalent in CRC patients (17.4%) compared with controls (11.1%) (crude OR 1.6; p = 0.03). The GSTM1-null genotype was found to be equally prevalent in cases and controls (53%). Multivariate analysis showed a significant 1.7-fold risk for CRC associated with the GSTT1-null genotypes (p = 0.04) and this increased to 2.9 for smokers (p = 0.02).


CONCLUSIONS
This study provides evidence of gene-environment interaction and illustrates the importance of further research into the role of genetic susceptibility for CRC.
Laso
N
N
Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, E-08036 Barcelona, Spain.
Lafuente
M J
MJ
Mas
S
S
Trias
M
M
Ascaso
C
C
Molina
R
R
Ballesta
A
A
Rodriguez
F
F
Lafuente
A
A
D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1