[Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously].
The changes of the histological structure of intact skin and of the skin within the area of burn trauma, caused by treatment with methyluracil-containing ointments, were studied. Morphometric investigations employing computer technologies have been performed using "DiaMorph" device-program complex (Russia). It was established that methyluracil possessed wound-healing properties by stimulating epidermal proliferation in the zone of injury and by modifying an inflammatory reaction enhancing its fibroblastic component. Daily applications of methyluracil to intact skin for a period of half a year resulted in some reduction of reserve capabilities of cambial keratinocytes, that was objectively manifested by a decrease of epidermal germinal layer thickness.
Nozdrin
V I
VI
Retinoids Parmaceutical Scientific-Production Enterprise, Moscow.
Belousova
T A
TA
Iatskovskiĭ
A N
AN
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004817:Epidermis / Q000187:drug effects / Q000473:pathology*; D005260:Female; D008297:Male; D009824:Ointments; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D009824:Ointments; D014498:Uracil; C008378:6-methyluracil