HIV update 2002: delaying treatment to curb rising resistance.
The recommendation for HIV antiretroviral therapy is changing from "treat early, treat hard" to "treat a little later, treat hard" as more toxicities of the drugs are recognized. Drug-resistant HIV is becoming a serious problem, even in treatment-naive patients. For HIV patients with organ failure, transplantation is increasingly an option.
Armstrong
Wendy
W
Department of Infectious Disease, The Cleveland Clinic Foundation, OH 44195, USA. armstrw@ccf.org
Calabrese
Leonard
L
Taege
Alan
A
D016915:AIDS Vaccines / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000639:trends*; D003906:Developing Countries; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D009369:Neoplasms / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology / Q000601:surgery; D014184:Transplantation, Homologous / Q000639:trends
D016915:AIDS Vaccines