title: Significance of tumor-associated antigens in the diagnosis and therapy of cancer: an overview.
abstract: An enormous effort using a wide variety of approaches has been undertaken over the last three decades to transform both basic and clinical research into improved diagnoses and therapies of cancer. This brief overview summarizes the significance of tumor-associated antigens (TAAs) in the diagnosis and therapy of cancer. Current data suggest that immunotherapy and gene therapy using antibody-recognized TAAs as their targets are promising, whereas those using T cell-recognized peptide epitopes of TAAs as their targets remain controversial regarding their efficacy, mainly due to general losses of HLA molecules in tumor cells.
authors.affiliation: Department of Biochemistry, Fukuoka University School of Medicine, 7-45-1 Jonan-ku, Fukuoka, 814-0180, Japan. kurokima@fukuoka-u.ac.jp
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
authors.forename: Aruto
authors.initials: A
authors.lastname: Ueno
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Abe
authors.forename: Tieli
authors.initials: T
authors.lastname: Li
authors.forename: Takayuki
authors.initials: T
authors.lastname: Imakiire
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Uno
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shirota
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Shibaguchi
authors.forename: Motomu
authors.initials: M
authors.lastname: Kuroki
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate