title: Local differences in the trabecular bone structure of the proximal femur depicted with high-spatial-resolution MR imaging and multisection CT.
abstract: OBJECTIVE
  The authors performed this study to investigate structural variations in the trabecular bone of the proximal femur at high-resolution magnetic resonance (MR) imaging and high-resolution multisection computed tomography (CT).
  
  
  METHODS
  Bone mineral density (BMD) was measured in 36 proximal human femur specimens by using dual x-ray absorptiometry. High-resolution MR imaging was performed at 1.5 T with an in-plane spatial resolution of 0.195 x 0.195 mm and a section thickness of 0.3 and 0.9 mm. Multisection CT was performed with an ultra-high-resolution protocol; images were obtained with an in-plane spatial resolution of 0.25 mm and a section thickness of 1 mm. In a subset of these specimens, micro CT was performed with an isotropic spatial resolution of 30 microm. Identical regions of interest (ROIs) were used to analyze images obtained with MR imaging, multisection CT, and micro CT. Trabecular bone structural parameters were obtained, and the parameters from the individual imaging modalities and BMD were correlated.
  
  
  RESULTS
  Significant differences concerning the trabecular microarchitecture between the individual ROIs were demonstrated with multisection CT and MR imaging. A number of the correlations between structural parameters derived with multisection CT, MR imaging, micro CT, and BMD measurements were significant. For MR imaging, threshold technique and section thickness had an effect on structural parameters.
  
  
  CONCLUSIONS
  Structural parameters obtained in the proximal femur with multisection CT and high-resolution MR imaging show regional differences. These techniques may be useful for depicting the trabecular architecture in the diagnosis of osteoporosis.
authors.affiliation: Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, USA.
authors.forename: Ahi Sema
authors.initials: AS
authors.lastname: Issever
authors.forename: Volker
authors.initials: V
authors.lastname: Vieth
authors.forename: Albrecht
authors.initials: A
authors.lastname: Lotter
authors.forename: Norbert
authors.initials: N
authors.lastname: Meier
authors.forename: Andres
authors.initials: A
authors.lastname: Laib
authors.forename: David
authors.initials: D
authors.lastname: Newitt
authors.forename: Sharmila
authors.initials: S
authors.lastname: Majumdar
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Link
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed