GDNF and somatostatin in sensory neurones.
Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory neurones exerts anti-inflammatory actions. The expression of SOM in sensory neurones can be modulated by the trophic factor glial-cell-line-derived neurotrophic factor (GDNF). Recent data show that GDNF modulates activity-induced release of endogenous SOM from both central and peripheral terminals of adult sensory neurones. This novel mechanism deserves exploration as a potential new therapeutic strategy to control two major features of inflammation: pain and leukocyte recruitment.
Malcangio
Marzia
M
Sensory Function Group, Centre for Neuroscience, Hodgkin Building, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK. Marzia.Malcangio@kcl.ac.uk
D000818:Animals; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D009414:Nerve Growth Factors / Q000819:agonists / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D013004:Somatostatin