title: Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000.
abstract: The authors examined the pattern of use of psychiatric medication as prescribed by community physicians in 1,155 patients with probable Alzheimer's disease (AD) referred to the Alzheimer's Disease Research Center of Pittsburgh between April 1983 and July 2000. The use of antidepressants and of sedatives, hypnotics, and anxiolytics (SHA) increased over time, while the use of antipsychotics decreased. The increased use of antidepressants and decreased use of antipsychotics may reflect the growing evidence that newer antidepressants (e.g., selective serotonin reuptake inhibitors) can be used to treat not only mood-related disorders, but also abnormal behavior (e.g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades.
authors.affiliation: Alzheimer's Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA. Lopezol@msx.upmc.edu
authors.forename: Oscar L
authors.initials: OL
authors.lastname: Lopez
authors.forename: James T
authors.initials: JT
authors.lastname: Becker
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sweet
authors.forename: William
authors.initials: W
authors.lastname: Klunk
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Kaufer
authors.forename: Judith
authors.initials: J
authors.lastname: Saxton
authors.forename: Steven T
authors.initials: ST
authors.lastname: DeKosky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004363:Drug Utilization / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010414:Pennsylvania; D011619:Psychotropic Drugs / Q000008:administration & dosage* / Q000009:adverse effects; D012042:Registries; D016896:Treatment Outcome
chemical_list: D011619:Psychotropic Drugs