Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines.
[reaction: see text] To improve upon the previous orthogonal method for synthesis of a triazine library, an alternative strategy has been developed via oxidation-activation of the thioether to the sulfone. Through a comparison between these two methods, the sulfone strategy was demonstrated as an enhanced method in the generation of highly pure triazine library compounds.
Bork
Jacqueline T
JT
Department of Chemistry, New York University, New York, New York 10003, USA.
Lee
Jae Wook
JW
Khersonsky
Sonya M
SM
Moon
Ho-Sang
HS
Chang
Young-Tae
YT
D020650:Combinatorial Chemistry Techniques; D012117:Resins, Synthetic; D014227:Triazines / Q000138:chemical synthesis*; D050257:Tubulin Modulators
D012117:Resins, Synthetic; D014227:Triazines; D050257:Tubulin Modulators