title: [Nonsyndromic deafness and mitochondrial DNA mutation].
abstract: OBJECTIVE
  To analysis whether there is any mtDNA 1555A-->G homoplasmic point mutation among familial nonsyndromic deafness.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to screen the mutation 1555A-->G among four nonsyndromic deafness families.
  
  
  RESULTS
  The same mutations were checked out in 4 of 5 individuals in 1 of 4 families.
  
  
  CONCLUSIONS
  The 1555A-->G change on mtDNA might be one of the multiple genetic defects and pathogenetic of familial nonsyndromic deafness.
authors.affiliation: First Hospital, Beijing Medical University, Beijing 100034.
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
authors.forename: X M
authors.initials: XM
authors.lastname: Ke
authors.forename: Z P
authors.initials: ZP
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D000328:Adult; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D017354:Point Mutation
chemical_list: D004272:DNA, Mitochondrial