Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies.
The classification and grading of the non-invasive, intraepithelial neoplasms of the urothelium are based on the morphological pattern of growth-that is, papillary or flat (and endophytic)-and on their degree of architectural and cytological abnormalities. Recent advances in the morphological, molecular, and quantitative evaluation of these lesions have contributed to the refinement of the current classification and grading schemes. However, some controversies on the precise criteria and terminology, especially when the papillary lesions are concerned, are still present.
Montironi
R
R
Institute of Pathological Anatomy and Histopathology, Ancona University School of Medicine, I-60020 Torrette, Ancona, Italy. r.montironi@unian.it
Lopez-Beltran
A
A
Mazzucchelli
R
R
Bostwick
D G
DG
D002278:Carcinoma in Situ / Q000145:classification / Q000235:genetics / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000145:classification / Q000235:genetics / Q000473:pathology*; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D019656:Loss of Heterozygosity; D009626:Terminology as Topic; D001749:Urinary Bladder Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*