[Clinical effects of intra-arterial nitrogen mustard (NH2) chemotherapy during operation for oral cancer].
OBJECTIVE
To discuss the general and local side-effects and clinic appliance of the intra-arterial chemotherapy, and evaluate the short-time clinic effects of the intra-arterial chemotherapy.


METHODS
From February, 1997 to December, 1997 11 patients with oral cancer (9 cases with lingual carcinoma, 2 cases with mouth carcinoma) were received one-shot chemotherapy during operation by NH2 catheterizing of lingual arteries (concentration of 1 mg/ml, dosage of 5 mg), and the other 16 oral cancer patients (13 cases with lingual carcinoma, 3 cases with mouth carcinoma) were only received operation as the control. At the same time, all patients were treated with Chinese flaps or Major pectoris myocutanous flaps homochronously. Then the general and local side-effects including the flap complexion were observed 1 week post-operatively and the follow-up was done in a shot time of 3-12 months.


RESULTS
No obvious general and local side-effects (including blood, mal function of liver and kidney, flap complexion, vomit and hemiplegia) happened and all the 11 flaps (6 Chinese flaps, 5 major pectoris myocutanous flaps) were alive in the experimental group. The local recurrent rate of the experimental group was 9.1%, while the rate was 18.8% in the control group (following up of 3-12 months). There was no significant difference between the experiment and the control groups by Student t-test.


CONCLUSIONS
The one-shot chemotherapy intra-operationally is a method with few side-effects, and it doesn't injure the homochronously reconstructed flaps. It might be an effective means of reducing the local recurrence of oral cancer.
He
Y
Y
School of Stomatology, Shanghai Second Medical University.
Guo
W
W
Zhang
C
C
Zhu
H
H
Zhang
Z
Z
D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013524:Surgical Flaps; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000601:surgery
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine