title: No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics.
abstract: OBJECTIVE
  We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits.
  
  
  METHODS
  The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted.
  
  
  RESULTS
  High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls.
  
  
  CONCLUSIONS
  Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
authors.affiliation: Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 München, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Koller
authors.forename: B
authors.initials: B
authors.lastname: Bondy
authors.forename: U W
authors.initials: UW
authors.lastname: Preuss
authors.forename: M
authors.initials: M
authors.lastname: Bottlender
authors.forename: M
authors.initials: M
authors.lastname: Soyka
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000523:psychology; D000483:Alleles; D000987:Antisocial Personality Disorder / Q000201:enzymology / Q000235:genetics* / Q000523:psychology; D041321:Chromosomes, Human, X; D018900:Dinucleotide Repeats / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D005838:Genotype; D006801:Humans; D007438:Introns; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D008995:Monoamine Oxidase