title: Chronic lymphocytic leukaemia developing in the course of chronic myeloid leukaemia.
abstract: Both chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL) are rare illnesses. Their co-existence has been previously reported, typically with CML following CLL. We report to our knowledge the first case of CLL developing some years after initial diagnosis of Philadelphia (Ph) chromosome positive CML. We provide molecular evidence that CLL arose in a Ph negative clone. The implications of the findings are discussed.
authors.affiliation: Department of Haematology, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK. rahuman.salim@rlbuh-tr.nwest.nhs.uk
authors.forename: R
authors.initials: R
authors.lastname: Salim
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Lin
authors.forename: R E
authors.initials: RE
authors.lastname: Clark
mesh_terms: D001549:Benzamides; D002999:Clone Cells / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D000068877:Imatinib Mesylate; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use
chemical_list: D001549:Benzamides; D007143:Immunoglobulin Heavy Chains; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate