[Changes serum level of tumor specific growth factor and their clinical significance in mechanical trauma patients].
OBJECTIVE
To investigate the post-traumatic changes in the serum level of tumor specific growth factor (TSGF) and their relationship with Injury Severity Score and to inquire into the possible mechanism and clinical significance.


METHODS
Fifty patients with mechanical trauma were eligible and included. According to the standard of Injury Severity Score (ISS), the patients were divided into there groups: mild degree group, (ISS < or = 16, n = 31) severe degree group (16 < ISS < 25, n = 13) extreme severe degree group (ISS > or = 25, n = 6). The blood samples of all patients were obtained within 24 hours, and those of 25 dynamically observed patients were obtained on days 3, 5, 7, 9 and 12.


RESULTS
The serum level of TSGF was significantly higher in patients with trauma in different groups (P < 0.05). The dynamical observation showed that the index demonstrated curve changes with increase in early stage and decrease later. the climax of TSGF appeared on 7 day in all 3 groups. The TSGF serum levels in extremely severe degree and severe degree groups > mild degree group on days 5, 7, 9 and 12 day (P < 0.05).


CONCLUSIONS
TSGF has relationship with the inflammatory response and recovery of trauma.
Zhang
X
X
Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Li
Y
Y
Wu
D
D
Wu
J
J
Cheng
Q
Q
Zeng
X
X
Liu
X
X
D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D001696:Biomechanical Phenomena; D005260:Female; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood*
D000951:Antigens, Neoplasm; D006133:Growth Substances; D009363:Neoplasm Proteins; C000594811:TSGF protein, human