X-chromosome inactivation: X marks the spot for BRCA1.
X-chromosome inactivation equalizes the dosage of X-linked genes in XX females with that in XY males. Recent findings reveal that the BRCA1 breast cancer susceptibility gene has an important function in this epigenetic phenomenon.
Stone
Caroline
C
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, SW3 6JB, London, UK.
McCabe
Nuala
N
Ashworth
Alan
A
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D008297:Male; D013045:Species Specificity; D014960:X Chromosome / Q000235:genetics