title: Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors.
abstract: Management of bleeding in haemophiliacs with a history of inhibitor remains problematic. With infusion of factor VIII (FVIII), development of an anamnestic response and possible appearance of high-titre inhibitor remains a valid concern. We report a case of a haemophiliac with a history of moderately high-titre FVIII inhibitor that had become undetectable. He had not received FVIII since 1997, when he became inhibitor negative. He had been managed during his bleeding episodes with prothrombin complex factor concentrates, which became less effective in controlling his bleeding. The patient had a history of recurrent, spontaneous shoulder joint dislocations with bleeding, pain and significant disability. Shoulder joint replacement surgery was suggested. Replacement therapy was discussed with the patient, who refused treatment with human FVIII because of his concern for possible anamnestic response and inhibitor rebound. Porcine FVIII was not acceptable due to his poor response when used once in the past, and his history of moderate allergic reaction. Therefore, recombinant factor VIIa (NovoSeven, Novo Nordisk, Princeton, NJ) was considered to be an acceptable option for the contemplated shoulder surgery. The patient underwent 2.5 h of surgery with NovoSeven infusion. The surgeons were impressed with the lack of bleeding in this traumatic surgery. Despite the continuously prolonged activated partial thromboplastin time and low FVIII levels, the patient maintained a remarkably dry surgical field. Effective haemostasis was achieved during and after this procedure. This case illustrates the usage of NovoSeven as an effective treatment modality in a haemophilia A patient with past history of inhibitor undergoing joint surgery.
authors.affiliation: Adult Comprehensive Hemophilia Treatment Center, Department of internal medicine, University of South Florida College of Medicine, Tampa, FL, USA. genevieve.morelli@med.va.gov
authors.forename: H I
authors.initials: HI
authors.lastname: Saba
authors.forename: G A
authors.initials: GA
authors.lastname: Morelli
authors.forename: R R
authors.initials: RR
authors.lastname: Azam
authors.forename: C J
authors.initials: CJ
authors.lastname: Klein
authors.forename: G D
authors.initials: GD
authors.lastname: Letson
mesh_terms: D000328:Adult; D019643:Arthroplasty, Replacement; D005167:Factor VII / Q000627:therapeutic use*; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D015942:Factor VIIa; D006467:Hemophilia A / Q000188:drug therapy*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012783:Shoulder Dislocation / Q000601:surgery
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa