Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats.
We demonstrated recently a significantly lower fraction of cardiac precapillary arterioles that expressed smooth muscle myosin heavy chain (MyHC) B (SMB) in spontaneously hypertensive rats. To clarify whether this reduction of SMB expression is of genetic origin, we investigated SMB expression in cardiac precapillary arterioles of normotensive and experimentally hypertensive rats (one clip, one kidney or ANG II minipump). We observed similar SMB expression patterns in precapillary arterioles of experimentally hypertensive rats compared with normotensive controls. These observations suggest that the downregulation of SMB in spontaneously hypertensive rats is of genetic origin rather than an adaptive response to chronically enhanced blood pressure and cardiac hypertrophy.
Wetzel
Katharina
K
Max Delbrück Center for Molecular Medicine, 13122 Berlin-Buch, Germany.
Baltatu
Ovidiu
O
Nafz
Benno
B
Persson
Pontus B
PB
Haase
Hannelore
H
Morano
Ingo
I
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D006332:Cardiomegaly / Q000378:metabolism*; D004195:Disease Models, Animal; D015536:Down-Regulation; D005455:Fluorescent Antibody Technique; D005786:Gene Expression Regulation; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D024501:Nonmuscle Myosin Type IIB; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley
D024501:Nonmuscle Myosin Type IIB; C103815:nonmuscle myosin type IIB heavy chain; D018995:Myosin Heavy Chains