Hepcidin, a new iron regulatory peptide.
Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction. Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis.
Nicolas
Gaël
G
Département de génétique, développement et Pathologie Moléculaire, Institut Cochin, Faculté de Médecine Cochin-Port Royal, 24 rue du Fg St Jacques, 75014 Paris, France.
Viatte
Lydie
L
Bennoun
Myriam
M
Beaumont
Carole
C
Kahn
Axel
A
Vaulont
Sophie
S
D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D004921:Erythropoietin / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D064451:Hepcidins; D007501:Iron / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data
D023181:Antimicrobial Cationic Peptides; C579599:Hamp protein, mouse; D064451:Hepcidins; D004921:Erythropoietin; D007501:Iron