[Study on correlation between in vivo and in vitro tests of biomaterials--correlation between leukocyte chemotaxis test and muscular implant test in rabbits].
The purpose of this study was to investigate the correlation between the results of in vivo and in vitro tests of biomaterials. With muscular implant test and leukocyte chemotaxis test, the levels of tissue toxicity of seven biomaterials were evaluated. The samples with high-level toxicity showed weak leukocyte chemotaxis, which would influence the anti-inflammatory reaction to foreign bodies. By the method of Spearman rank correlation, the coefficient was between 0.89286-0.98198 indicating that the correlation of the two tests is excellent.
Wen
X
X
Shanghai Biomaterial Research and Test Center, No. 9 Hospital, Shanghai Second Medical University, Shanghai 200023.
Zhang
C
C
Liu
X
X
Gu
G
G
Qian
Y
Y
Meng
A
A
Huang
Z
Z
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D066298:In Vitro Techniques; D008422:Materials Testing / Q000379:methods*; D009132:Muscles / Q000637:transplantation; D011817:Rabbits
D001672:Biocompatible Materials