[Study on IGF-I regulation the proliferation of rat condylar chondrocytes in vitro].
This study was aimed at the mechanism for the changes in the proliferation of cultured rat mandibular condylar chondrocytes. Flow cytometry was used to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes. The results showed that when the mandibular condylar chondrocytes were cultured with IGF-I for 24 hours and 96 hours, the cellular proliferation in the experimental group enhanced higher than that in the control group. It was implied that IGF-I may be a mitogen on rat mandibular condylar chondrocytes. The mitogenic effect of IGF-I had a lag period.
Yang
H
H
Department of Cariology, School of Stomatology, WCUMS, Chengdu 610041.
Luo
S
S
Li
F
F
Zhou
Z
Z
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology*; D004247:DNA / Q000096:biosynthesis; D005434:Flow Cytometry; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008335:Mandibular Condyle / Q000166:cytology*; D051381:Rats
D007334:Insulin-Like Growth Factor I; D004247:DNA