Regioselective sulfonylation at O-2 of cyclomaltoheptaose with 1-(p-tolylsulfonyl)-(1H)-1,2,4-triazole.
2(I)-O-p-Tolylsulfonylcyclomaltoheptaose was obtained in 42% yield by reaction of 1-(p-tolylsulfonyl)-(1H)-1,2,4-triazole on NaH-deprotonated cyclomaltoheptaose in DMF and further converted into the corresponding mono-2(I),3(I)-manno-epoxide.
Law
Ho
H
Département de Pharmacochimie Moléculaire, CNRS and Université Joseph Fourier-Grenoble 1 (UMR 5063), BP 138, F-38243, Meylan, France.
Baussanne
Isabelle
I
García Fernández
José M
JM
Defaye
Jacques
J
D003505:Cyclodextrins / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D014230:Triazoles; D047392:beta-Cyclodextrins; C031215:betadex