[An experimental study on effects of pingyangmycin on vessels].
OBJECTIVE
The aim of this study was to investigate the mechanism of Pingyangmycin sclerotherapy for cavernous hemangiomas.


METHODS
Totally 9 rabbits (one as the control) were selected to be injected with Pingyangmycin and sodium morrhuate into the auricularis posterior vein, and then these veins were examined histologically 2, 7, 14 and 21 days after injection respectively.


RESULTS
After injection, Pingyangmycin nonspecifically made the endothelia and veins defective, and induced proliferation of endothelial cells and smooth muscle cells after 7 days. Further, the veins became sclerostenosis 21 days after injection. On the other hand, sodium morrhuate caused thrombosis quickly and the vascular cavity disappeared. Finally, the thrombus became fibrogenesis. The local skin could be observed swollen and necrosis.


CONCLUSIONS
Pingyangmycin is a better sclerosant for the therapy of cavernous hemangioma.
Gao
Q
Q
College of Stomatology, West China University of Medical Sciences.
Wang
C
C
Wen
Y
Y
Li
L
L
Zhang
J
J
He
Z
Z
Yang
Z
Z
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004431:Ear, External / Q000098:blood supply; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006392:Hemangioma, Cavernous / Q000188:drug therapy*; D015552:Injections, Intralesional; D008297:Male; D011817:Rabbits; D015911:Sclerotherapy; D014680:Veins / Q000187:drug effects / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C021771:zhengguangmycin