[A water-soluble synthetic polymer, alpha,beta-poly(hydroxyalkyl)-DL-asparamide, and conjugating drug].
A water-soluble polymer alpha,beta-poly (hydroxyalkyl)-DL-asparamide was synthesized by polysuccinimide(PSI) and different lengths of hydroxyalkyls, including alpha,beta-poly(hydroxyethyl)-DL-asparamide(PHEA), alpha,beta-poly(hydroxypropyl)-DL-asparamide(PHPA), and alpha,beta-poly(hydroxybutyl)-DL-asparamide(PHBA). These polymers were characterized by differential scanning calorimetry(DSC) and infrared spectrophotometry(IR). Stability and acutetoxicity of these polymers were studied. The experiment indicated that these materials were of low-toxicity and high stability. Acetylsalicylic acid, as a model drug, was conjugated into polymers; the drug loadings were 38.63%, 37.68% and 38.70% respectively. Polymer drugs were made into cylinder, and in-vivo release in rabbits was set out. It showed that the longer the spacer was linked into the polymer, the faster the drug was released.
Zhang
Z
Z
Department of Pharmacy, Zhejiang Medical University, Hangzhou 310031.
Tang
G
G
Chen
Q
Q
Wang
B
B
Ma
M
M
Zhang
X
X
D000818:Animals; D001224:Aspartic Acid; D001241:Aspirin / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D004337:Drug Carriers; D005260:Female; D008297:Male; D008422:Materials Testing; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis*; D011817:Rabbits
D004337:Drug Carriers; D010455:Peptides; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); D001224:Aspartic Acid; D001241:Aspirin