title: [Herpesviridae and laryngeal neoplasia].
abstract: OBJECTIVE
  To investigate the relationship between herpesviridae and malignant or benign laryngeal diseases.
  
  
  METHODS
  128 paraffin-embedded laryngeal squamous cell carcinoma and laryngeal epithelium hyperplastic lesions were detected by polymerase chain reaction (PCR) and PCR-ISH for herpesviridae.
  
  
  RESULTS
  HSV-1 was detected in 10 cases by PCR, among them 3 were laryngeal squamous cell carcinoma (LSCC), 1 was carcinoma in situ(CIS), 4 were laryngeal polyps and 2 were laryngeal keratosis. Except 1 LSCC and 1 CIS 8 of 10 cases were positive while detected by PCR-ISH. In benign diseases, signals were shown from basal layer to superficial cell; in malignant lesions, the signals were scattered in the diseases.
  
  
  CONCLUSIONS
  Most of laryngeal diseases were not related to herpesviridae, but HSV-1 may acts as initiator in the development of a few cases.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005.
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Jiang
authors.forename: W
authors.initials: W
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: Z
authors.initials: Z
authors.lastname: Yi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology; D005260:Female; D006564:Herpesviridae / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000473:pathology*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D006801:Humans; D007818:Laryngeal Diseases / Q000821:virology*; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000821:virology; D011230:Precancerous Conditions / Q000821:virology