[The effect of glucocorticoid on neural system development].
During the early developmental period of central nerves system, glucocorticoid can influence the activity of hypothalamic-pituitary-adrenocortical axis via glucocorticoid receptors, and modulate the process of neural survival, outgrowth and programming death process; In adult, glucocorticoid can regulate the expression of the factors which correlate with the plasticity of neurons; In aged individual, glucocorticoid can be harmful to nerves under most conditions. Therefore, glucocorticoid plays an important role in the development of neural system.
Hu
J F
JF
Institute of Psychology, Chinese Academy of Sciences, Beijing 100101.
Sui
N
N
Kuang
P Z
PZ
Guan
L C
LC
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000502:physiology*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid