title: End-expiratory lung impedance change enables bedside monitoring of end-expiratory lung volume change.
abstract: OBJECTIVE
  The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside.
  
  
  METHODS
  Clinical trial on patients requiring mechanical ventilation.
  
  
  METHODS
  Intensive care units of a university hospital.
  
  
  METHODS
  Ten mechanically ventilated patients were included in the study.
  
  
  METHODS
  Patients were ventilated in volume-controlled mode with constant flow and respiratory rate. In order to induce changes in the end-expiratory lung volume (EELV), PEEP levels were increased from 0 mbar to 5 mbar, 10 mbar, and 15 mbar. At each PEEP level EELV was measured by an open-circuit nitrogen washout manoeuvre and ELIC was measured simultaneously using Electrical Impedance Tomography (EIT) with sixteen electrodes placed on the circumference of the thorax and connected with an EIT device. Cross-sectional electro-tomographic measurements of the thorax were performed at each PEEP level, and a modified Sheffield back-projection was used to reconstruct images of the lung impedance. ELIC was calculated as the average of the end-expiratory lung impedance change. RESULTS. Increasing PEEP stepwise from 0 mbar to 15 mbar resulted in an linear increase of EELV and ELIC according to the equation: y =0.98 x -0.68, r(2)=0.95.
  
  
  CONCLUSIONS
  EIT is a simple bedside technique which enables monitor lung volume changes during ventilatory manoeuvres such as PEEP changes.
authors.affiliation: Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany. mail@josehinz.de
authors.forename: J
authors.initials: J
authors.lastname: Hinz
authors.forename: G
authors.initials: G
authors.lastname: Hahn
authors.forename: P
authors.initials: P
authors.lastname: Neumann
authors.forename: M
authors.initials: M
authors.lastname: Sydow
authors.forename: P
authors.initials: P
authors.lastname: Mohrenweiser
authors.forename: G
authors.initials: G
authors.lastname: Hellige
authors.forename: H
authors.initials: H
authors.lastname: Burchardi
mesh_terms: D000328:Adult; D000368:Aged; D017097:Electric Impedance; D006801:Humans; D016018:Least-Squares Analysis; D008176:Lung Volume Measurements / Q000379:methods*; D008875:Middle Aged; D009584:Nitrogen / Q000032:analysis; D019095:Point-of-Care Systems; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics; D018709:Statistics, Nonparametric; D014054:Tomography / Q000379:methods*
chemical_list: D009584:Nitrogen