[The degradation performance of bioabsorbable acylchitin fiber reinforced PLA composite materials in vitro and in vivo].
The present authors have investigated the degradation performance of acylchitin fiber reinforced polylactide composite materials plates both in vitro and in vivo. The initial flexural strength and the initial flexural modulus of this plate are 114.72 MPa and 3980.05 MPa, respectively. The flexural strength of this plate decreases to 31.42 MPa after the plate has been submerged in injectio natrii lactatic ringeri tissue fluid for a period of 16 weeks at 37 degrees C. Both the in vitro degradation performance and the strength retention of this plate are better than those of the self-reinforced PGA/PLA and PGA, though the initial strength of the latter two being much higher than that of the former. The degradation products of the chitin/PLA composite materials can be absorbed by metabolic pathway.
Chen
C
C
Institute of Composite Materials, Shanghai Jiaotong University, Shanghai 200030.
Cheng
H
H
Sun
K
K
Wu
R
R
Jiang
R
R
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002483:Cellulose, Oxidized / Q000737:chemistry / Q000493:pharmacokinetics*; D002686:Chitin / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics*; D019736:Prostheses and Implants; D011817:Rabbits; D013718:Tensile Strength
D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D011091:Polyesters; D002686:Chitin; C033616:poly(lactide)