title: Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop.
abstract: BACKGROUND
  Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification.
  
  
  METHODS
  This study analyzes 48 cases of primary cutaneous lymphoma expressing cytotoxic proteins and/or the NK cell marker, CD56. These cases were collected for a workshop of the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Task Force, to better clarify the clinical, morphologic, and phenotypic features of these uncommon tumors.
  
  
  RESULTS
  Several categories with different clinical and pathologic features were delineated: 1) aggressive, CD8+, epidermotropic, cytotoxic T-cell lymphoma; 2) mycosis fungoides, cytotoxic immunophenotype variant; 3) subcutaneous panniculitis-like T-cell lymphoma; 4) NK/T-cell lymphoma, nasal type; 5) CD4+, NK cell lymphoma; 6) blastoid NK cell lymphoma; (7) intravascular NK-like lymphoma; and 8) cytotoxic, peripheral T-cell lymphoma.
  
  
  CONCLUSIONS
  Our data show that primary cutaneous cytotoxic/NK cell lymphomas include distinct groups of diseases, clinically, histologically, and biologically. Because the finding of a cytotoxic phenotype often has prognostic significance, the routine use of cytotoxic markers in the diagnosis and classification of cutaneous lymphomas should be expanded.
authors.affiliation: Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy. Marco.Santucci@UNIFI.IT
authors.forename: Marco
authors.initials: M
authors.lastname: Santucci
authors.forename: Nicola
authors.initials: N
authors.lastname: Pimpinelli
authors.forename: Daniela
authors.initials: D
authors.lastname: Massi
authors.forename: Marshall E
authors.initials: ME
authors.lastname: Kadin
authors.forename: Chris J L M
authors.initials: CJ
authors.lastname: Meijer
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: Marco
authors.initials: M
authors.lastname: Paulli
authors.forename: Janine
authors.initials: J
authors.lastname: Wechsler
authors.forename: Rein
authors.initials: R
authors.lastname: Willemze
authors.forename: Heike
authors.initials: H
authors.lastname: Audring
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bernengo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerroni
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Andreas
authors.initials: A
authors.lastname: Chott
authors.forename: José L
authors.initials: JL
authors.lastname: Díaz-Pérez
authors.forename: Edgard
authors.initials: E
authors.lastname: Dippel
authors.forename: Lyn M
authors.initials: LM
authors.lastname: Duncan
authors.forename: Alfred C
authors.initials: AC
authors.lastname: Feller
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Geerts
authors.forename: Christian
authors.initials: C
authors.lastname: Hallermann
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Robin
authors.initials: R
authors.lastname: Russell-Jones
authors.forename: Christian
authors.initials: C
authors.lastname: Sander
authors.forename: Emilio
authors.initials: E
authors.lastname: Berti
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D019002:CD56 Antigen / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology; D008223:Lymphoma / Q000145:classification* / Q000276:immunology / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification / Q000276:immunology / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000145:classification / Q000276:immunology / Q000473:pathology; D008565:Membrane Proteins / Q000276:immunology*; D009182:Mycosis Fungoides / Q000276:immunology / Q000473:pathology; D015434:Panniculitis / Q000276:immunology / Q000473:pathology; D010641:Phenotype; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins / Q000276:immunology*; D012878:Skin Neoplasms / Q000145:classification* / Q000276:immunology / Q000473:pathology; D000074019:T-Cell Intracellular Antigen-1
chemical_list: D019002:CD56 Antigen; D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human