[Influence of anisodamine on guinea pig experimental nasal hypersensitivity].
OBJECTIVE
To observe the influence of anisodamine on guinea pig experimental nasal hypersensitivity.


METHODS
Experimental animals were divided into normal control group, TDI group, reserpine group and anisodamine group. The scores of symptom of nose and the cytologic changes of nasal mucosa were parameters of observing.


RESULTS
The nasal symptom of reserpine group was significantly stronger than the TDI group, and the eosinophilia evidently increased (both P < 0.01). The nasal symptom of the anisodamine group reduced and the eosinophilia decreased. It is significantly difference between the TDI group and the reserpine group (both P < 0.01).


CONCLUSIONS
Anisodamine may play a role in therapy of the experimental nasal hypersensitivity with hyperfunction of parasympathetic nerve.
Zhu
Z
Z
Department of Otolaryngology-Head and Neck Surgery, Chinese Japan United Hospital of Jilin University, Changchun 130031.
Dong
Z
Z
Yang
Z
Z
D000818:Animals; D006168:Guinea Pigs; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D009668:Nose Diseases / Q000188:drug therapy*; D010276:Parasympatholytics / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D012991:Solanaceous Alkaloids / Q000494:pharmacology*
D010276:Parasympatholytics; D012991:Solanaceous Alkaloids; C003922:anisodamine