title: A case report of difficult diagnosis in the patient with advanced laryngeal tuberculosis.
abstract: We report a patient with severe laryngeal tuberculosis (LTB) involving thyroid cartilage and combined with whole-bone metastasis. A 57-year-old male had presented only with hoarseness. Radiological findings were indicative of suspected metastasis from a malignant tumor. However, tuberculosis was considered by histopathological findings, and so sputum samples were tested for acid-fast bacilli and purified protein derivatives of tuberculin in order to detect the presence of LTB. A polymerase chain reaction confirmed the diagnosis. Anti-tuberculous medications were effective in resolving the hoarseness, and the removal of the mass in the right wing of thyroid cartilage was confirmed by computed tomography (CT).
authors.affiliation: Department of Otolaryngology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, 1197-1, Yasashi-chou, Asahi-ku, 241-0811, Yokohama, Japan. mkenmochi@marianna-u.ac.jp
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Kenmochi
authors.forename: Toru
authors.initials: T
authors.lastname: Ohashi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Nishino
authors.forename: Sigeki
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Izumi
authors.initials: I
authors.lastname: Koizuka
authors.forename: Toshihito
authors.initials: T
authors.lastname: Shinagawa
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D002574:Cervical Vertebrae / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006685:Hoarseness / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013957:Thyroid Cartilage / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014374:Tuberculin Test; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014399:Tuberculosis, Spinal / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014827:Vocal Cords / Q000473:pathology
chemical_list: D000995:Antitubercular Agents