title: 3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.
abstract: Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.
authors.affiliation: PGRD Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340, USA. michael_p_deninno@groton.pfizer.com
authors.forename: Michael P
authors.initials: MP
authors.lastname: DeNinno
authors.forename: Hiroko
authors.initials: H
authors.lastname: Masamune
authors.forename: Lois K
authors.initials: LK
authors.lastname: Chenard
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: DiRico
authors.forename: Cynthia
authors.initials: C
authors.lastname: Eller
authors.forename: John B
authors.initials: JB
authors.lastname: Etienne
authors.forename: Jeanene E
authors.initials: JE
authors.lastname: Tickner
authors.forename: Scott P
authors.initials: SP
authors.lastname: Kennedy
authors.forename: Delvin R
authors.initials: DR
authors.lastname: Knight
authors.forename: Jimmy
authors.initials: J
authors.lastname: Kong
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Oleynek
authors.forename: W Ross
authors.initials: WR
authors.lastname: Tracey
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hill
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D043684:Receptor, Adenosine A3; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; C471165:CP 608039; D007555:Isoxazoles; D058906:Purinergic P1 Receptor Agonists; D043684:Receptor, Adenosine A3; D000241:Adenosine