Propofol anaesthesia and metabolic acidosis in children.
BACKGROUND
We aimed to investigate the effect of propofol infusion anaesthesia on acid-base status and liver and myocardial enzyme levels of children during short-term anaesthesia.


METHODS
Thirty-six children, aged 3-12 years, were randomized into two groups. In group P (n = 18), induction and maintenance were performed with propofol, 3 mg x kg-1 and 20, 15 and 10 mg x kg-1 x h-1, respectively. In group H (n = 18) following induction with 5 mg x kg-1 thiopenthal, anaesthesia was maintained with 2-3% halothane. Blood samples were obtained following anaesthesia induction and 30, 60 and 120 min after discontinuation of anaesthesia.


RESULTS
There was no difference in lactate dehydrogenase, myocardial creatininephosphokinase, aspartate aminotransferase, alanine aminotransferase and cholesterol levels between and within the groups. All postoperative triglyceride levels were higher and pH levels were lower in group P than group H (P < 0.05) and there was no difference within the groups.


CONCLUSIONS
In these healthy patients, short-term use of propofol did not result in significant acidaemia, nor alterations in hepatic or myocardial enzyme levels.
Ozlü
Onur
O
Department of Anesthesia, Ankara Children Hospital, Ankara, Turkey. onurozluttnet.net.tr
Ozkara
H Asuman
HA
Eris
Senay
S
Ocal
Turgay
T
D000138:Acidosis / Q000209:etiology*; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001784:Blood Gas Analysis; D002648:Child; D002675:Child, Preschool; D006221:Halothane; D006801:Humans; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D015742:Propofol; D011446:Prospective Studies; D013997:Time Factors
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D006221:Halothane; D015742:Propofol