[The relationship between GPx activity in gingival fluid and clinical parameters of adult periodontitis].
OBJECTIVE
To study the relationship of glutathione peroxidase (a natural FR scavenger) in gingival cervical fluid (GCF) of patients with periodontitis.


METHODS
GCF was collected from 44 sites of 23 patients with adult periodontitis. The volume of GCF was measured with Periotron 8000. GCF-GPx activity was determined by DTNB methods before and after treatment, and the periodontal parameters GI, PD and AL were recorded.


RESULTS
GCF-GPx activity was negatively correlated with PD and AL (P < 0.01, P < 0.005), but was not correlated with GI (P > 0.05). After treatment, clinical parameters decreased while GCF-GPx activity increased (P < 0.001), but the increment of GCF-GPx activity showed no correlation with the base level and the changes of clinical parameters.


CONCLUSIONS
The imbalance between FR's production and scavenging might be an important pathological factor of periodontal diseases, and GCF-GPx might be a promising indicator of periodontal status.
Huang
P
P
College of Stomatology, West China University of Medical Sciences.
Su
T
T
Wang
H
H
D000328:Adult; D015415:Biomarkers; D005260:Female; D005881:Gingiva / Q000201:enzymology; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000201:enzymology* / Q000628:therapy; D010519:Periodontium / Q000201:enzymology*
D015415:Biomarkers; D005979:Glutathione Peroxidase