GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.
GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.
Jones-Davis
Dorothy M
DM
University of Michigan, Ann Arbor, MI 48104-1687, USA.
Macdonald
Robert L
RL
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D006801:Humans; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000378:metabolism
D000927:Anticonvulsants; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A