[Effect of 5 polycyclic aromatic hydrocarbons on estrogen receptor binding in rats].
The estrogenic activity of 5 polycyclic aromatic hydrocarbons(PAHs) of rat uterine wet weight bioassy and estrogen receptor binding bioassy are determined. The results show that penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene could statistically increase uterine wet weight of immature female rats(P < 0.01 or P < 0.05) while benz(a)anthracene and chrysene can not significantly increase uterine wet weight(P > 0.05). Penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene effectively inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P < 0.01). Whereas benz(a)anthracene and chrysene can not inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P > 0.05). The results from this study indicate that penzo(a)pyrene, 7,12-dimethyl benz(a) anthracene and pentacene have significant estrogenic activity.
Yang
Jianjun
J
Department of Toxicology, Second Military Medical University, Shanghai 200433, China.
Yin
Muquan
M
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D000831:Animals, Newborn; D000873:Anthracenes / Q000633:toxicity; D001564:Benzo(a)pyrene / Q000633:toxicity; D001665:Binding Sites / Q000187:drug effects; D002911:Chrysenes / Q000633:toxicity; D005260:Female; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D000873:Anthracenes; D002911:Chrysenes; D011084:Polycyclic Aromatic Hydrocarbons; D011960:Receptors, Estrogen; D001564:Benzo(a)pyrene; D015127:9,10-Dimethyl-1,2-benzanthracene