Modular organization of cellular networks.
We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.
Rives
Alexander W
AW
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.
Galitski
Timothy
T
D002450:Cell Communication; D016000:Cluster Analysis; D019992:Databases as Topic; D005656:Fungal Proteins / Q000378:metabolism*; D015398:Signal Transduction; D012984:Software
D005656:Fungal Proteins