title: Light-scattering instrument to detect thromboemboli in blood.
abstract: The characteristics and capabilities of a light-scattering microemboli detector (LSMD) are delineated by detailing its state-of-the-art configuration, by discussing the theoretical and empirical aspects of instrument calibration, and by summarizing various experimental studies that have benefited from this instrument. In the past, thromboembolism, which often results when blood contacts medical devices, has eluded scientific scrutiny due to the absence of instruments that could detect and quantify thromboemboli in circulating blood. More recently, the ability of the LSMD to provide continuous, noninvasive detection of thromboemboli in whole blood (meaning that the LSMD probe does not contact the blood) was exploited in various in vitro and ex vivo models to explore thromboembolic phenomena. Through this work, the LSMD evolved as a sensitive and an economical research tool for the study of thromboembolic phenomena.
authors.affiliation: Brigham Young University, Department of Chemical Engineering, Provo, Utah 84602, USA. kenneth_solen@byu.edu
authors.forename: Kenneth
authors.initials: K
authors.lastname: Solen
authors.forename: Sivaprasad
authors.initials: S
authors.lastname: Sukavaneshvar
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.forename: Brian
authors.initials: B
authors.lastname: Hanrahan
authors.forename: Matthew
authors.initials: M
authors.lastname: Hall
authors.forename: Paul
authors.initials: P
authors.lastname: Goodman
authors.forename: Benjamin
authors.initials: B
authors.lastname: Goodman
authors.forename: Fazal
authors.initials: F
authors.lastname: Mohammad
mesh_terms: D000783:Aneurysm / Q000097:blood / Q000628:therapy; D000818:Animals; D002417:Cattle; D004867:Equipment Design; D006353:Heart-Assist Devices / Q000009:adverse effects; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D008863:Microspheres; D008962:Models, Theoretical; D055095:Optics and Photonics / Q000295:instrumentation*; D012542:Scattering, Radiation; D012756:Sheep; D013923:Thromboembolism / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology