title: An investigation of the 5-HT2C receptor gene as a migraine candidate gene.
abstract: Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition.
authors.affiliation: Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Johnson
authors.forename: Rod A
authors.initials: RA
authors.lastname: Lea
authors.forename: Robert P
authors.initials: RP
authors.lastname: Curtain
authors.forename: John C
authors.initials: JC
authors.lastname: MacMillan
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D016022:Case-Control Studies; D041321:Chromosomes, Human, X; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics*; D012737:Sex Factors
chemical_list: D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin