title: Recent progress in artificial organ research at Tohoku University.
abstract: Tohoku University has developed various artificial organs over the last 30 years. Pneumatic driven ventricular assist devices with a silicone ball valve have been designed by the flow visualization method, and clinical trials have been performed in Tohoku University Hospital. On the basis of these developments, a pneumatic driven total artificial heart has been developed and an animal experimental evaluation was conducted. The development of artificial organs in Tohoku University has now progressed to the totally implantable type using the transcutaneous energy transmission system with amorphous fibers for magnetic shielding. Examples of implantable systems include a vibrating flow pump for ventricular assist device, an artificial myocardium by the use of shape memory alloy with Peltier elements, and an artificial sphincter for patients with a stoma. An automatic control system for artificial organs had been developed for the ventricular assist devices including a rotary blood pump to avoid suction and to maintain left and right heart balance. Based upon the technology of automatic control algorithm, a new diagnostic tool for evaluating autonomic nerve function has been developed as a branch of artificial organ research and this new machine has been tested in Tohoku University Hospital. Tohoku University is following a variety of approaches aimed at innovation in artificial organs and medical engineering fields.
authors.affiliation: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. yambe@idac.tohoku.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Abe
authors.forename: Satoyuki
authors.initials: S
authors.lastname: Kawano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Matsuki
authors.forename: Shigenao
authors.initials: S
authors.lastname: Maruyama
authors.forename: Shintato
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authors.lastname: Amae
authors.forename: Naoshi
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authors.lastname: Wada
authors.forename: Takamichi
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authors.lastname: Kamiyama
authors.forename: Toshiyuki
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authors.lastname: Takagi
authors.forename: Run
authors.initials: R
authors.lastname: Luo
authors.forename: Junko
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authors.lastname: Hayashi
authors.forename: Yuri A
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authors.lastname: Kovalev
authors.forename: Dan
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authors.lastname: X D Sha
authors.forename: Shunsuke
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authors.lastname: Nanka
authors.forename: Yoshifumi
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authors.lastname: Saijo
authors.forename: Yoshiyuki
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authors.lastname: Mibiki
authors.forename: Mune-ichi
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authors.lastname: Shibata
authors.forename: Shin-ichi
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authors.lastname: Nitta
mesh_terms: D000046:Academic Medical Centers; D000818:Animals; D001187:Artificial Organs; D006041:Goats; D006801:Humans; D007564:Japan; D012106:Research; D013552:Swine