Take care of your chromosomes lest cancer take care of you.
The analysis of compound mouse mutants for nonhomologous end-joining DNA double-strand break repair and those deficient for the p53 checkpoint pathway has provided a fascinating look at the carcinogenic consequences of the failure to properly repair DNA damage and to elicit appropriate checkpoints.
Maser
Richard S
RS
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. richard_maser@dfci.harvard.edu
DePinho
Ronald A
RA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D009369:Neoplasms / Q000209:etiology*