Effect of mifegin on the content of cyclic nucleotides in the cervical myometrium in full-term pregnancy.
Cervical myometrium was examined in 22 pregnant women at 39-41 weeks gestation at risk of labor abnormalities. The patients received mifegin for preparing to labor. A new component in the mechanism of mifegin effect on the uterine cervix in full-term pregnancy was revealed: mifegin elevated the content of cAMP by 50% and almost 2-fold increased the cAMP/cGMP ratio compared to the initial level.
Sergeev
P V
PV
Department of Molecular Pharmacology, Russian State Medical University, Russia.
Kareva
E N
EN
Gasparyan
N D
ND
Podval'nyuk
V V
VV
D000284:Administration, Oral; D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism; D015735:Mifepristone / Q000008:administration & dosage / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D011256:Pregnancy Outcome
D015735:Mifepristone; D000242:Cyclic AMP; D006152:Cyclic GMP