title: Changes in CAP adaptation in experimentally induced endolymphatic hydrops.
abstract: OBJECTIVE
  To determine the effect of experimentally induced endolymphatic hydrops (ELHs) on compound action potential (CAP) adaptation.
  
  
  METHODS
  The CAP was recorded 1 month after surgical treatment to produce ELH. The CAP threshold in response to click stimuli showed no significant differences between the hydropic and control groups. The CAP was elicited from the retroauricular-exposed round window using a silver ball electrode. Click trains consisting of 10 clicks with an interclick interval (Deltat) of either 4 or 8 ms were delivered through a loudspeaker placed in front of the animals' ears. The patterns of adaptation to these click trains were evaluated as functions of Deltat and intensity level.
  
  
  RESULTS
  An abnormal pattern of CAP adaptation was observed in hydropic ears.
  
  
  CONCLUSIONS
  These findings suggest that early ELH influences CAP adaptation.
authors.affiliation: Department of Otolaryngology, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ochi
authors.forename: Natsuki
authors.initials: N
authors.lastname: Sugiura
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Kenmochi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Nishino
authors.forename: Toru
authors.initials: T
authors.lastname: Ohashi
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D003051:Cochlea / Q000473:pathology / Q000503:physiopathology; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D018159:Endolymphatic Hydrops / Q000473:pathology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D008297:Male; D010897:Pitch Discrimination / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*