title: t(5;9)(q11;q34): a novel familial translocation involving Abelson oncogene and association with hypereosinophilia.
abstract: A 6-year-old girl with hypereosinophilia was found to have a familial constitutional translocation t(5;9)(q11;q34). Flow cytometry and gene rearrangement studies did not show any clonal T-helper cell proliferation. Presence of cryptic Philadelphia translocation was ruled out by reverse transcription polymerase chain reaction. Abelson oncogene translocation on chromosome 5 was confirmed by fluorescent in situ hybridization. This is the first example of a familial translocation involving the abelson oncogene and association with hypereosinophilia. The authors discuss a novel mechanism of hypereosinophilia involving the hybrid product of the abelson oncogene with an unknown partner gene on chromosome 5 (probably granzyme-A).
authors.affiliation: Division of Pediatric Hematology and Oncology, Children's Hospital of Michigan, 39012 Beaubien Boulevard, Detroit, MI 48201, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Merlin
authors.initials: M
authors.lastname: Hamre
authors.forename: Anwar N
authors.initials: AN
authors.lastname: Mohamed
authors.forename: Gerald
authors.initials: G
authors.lastname: Feldman
authors.forename: Yaddanapudi
authors.initials: Y
authors.lastname: Ravindranath
mesh_terms: D002648:Child; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics* / Q000473:pathology; D017404:In Situ Hybridization, Fluorescence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics*