title: Further important sensitizers in patients sensitive to fragrances.
abstract: In order to find sensitizers additional to the current fragrance mix (FM) a series of fragrance materials (series II) was evaluated in 6 dermatological centres in Europe. 11 of the test materials were essential oils, the remaining 7 being either mixtures of isomers or simple chemicals of frequent usage in the perfume industry. 1606 patients were consecutively tested with series II and 8% FM. Each patient was classified regarding a history of adverse reactions to scented products: certain, probable, questionable, none. Reactions to FM occurred most frequently in 11.4% of the subjects. The 6 materials with the highest reactivity after the FM were ylang-ylang oil (YY) I (2.6%), YY II (2.5%), lemongrass oil (1.6%), narcissus absolute (1.3%), jasmine absolute (1.2%) and sandalwood oil (0.9%). 48 (3.0%) of the patients reacted only to materials of series II and not to FM. 6.0% of 1606 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 22.9%, to series II and FM in 15.6% and to series II only in 5.2%. 63.5% of the patients reacting to both FM and 1 of the materials of series II had some type of positive fragrance history, which was higher in comparison to those with isolated reactions to FM (46.2% of 121) or to series II, respectively, (45.8% of 48). However, this difference was not statistically significant. In conclusion, the materials of series II identified a further subset of patients with a fragrance problem, which would have been missed by the current FM as the single screening tool for patch testing.
authors.affiliation: Department of Dermatology, Klinikum Dortmund gGmbH and University of Witten/Herdecke, Dortmund, Germany. P.Frosch@derma.de
authors.forename: P J
authors.initials: PJ
authors.lastname: Frosch
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: C
authors.initials: C
authors.lastname: Pirker
authors.forename: S C
authors.initials: SC
authors.lastname: Rastogi
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: A
authors.initials: A
authors.lastname: Goossens
authors.forename: J P
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: I R
authors.initials: IR
authors.lastname: White
mesh_terms: D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D005060:Europe; D006801:Humans; D007509:Irritants; D010328:Patch Tests / Q000592:standards*; D010476:Perfume / Q000009:adverse effects; D010938:Plant Oils
chemical_list: D007509:Irritants; D010476:Perfume; D010938:Plant Oils