Expression of 1A6 gene and its correlation with intestinal gastric carcinoma.
OBJECTIVE
To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.


METHODS
One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.


RESULTS
The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant.


CONCLUSIONS
As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
Liu
Yi-Qiang
YQ
Department of Pathology, Peking University School of Oncology, Beijing 100036, China.
Zhao
Hong
H
Ning
Tao
T
Ke
Yang
Y
Li
Ji-You
JY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D012016:Reference Values; D012509:Sarcoma / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D014408:Biomarkers, Tumor; D014157:Transcription Factors