Effects of acute and chronic caffeine intake on intravenous self-administration of morphine in two rat strains.
Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed.
Sudakov
S K
SK
Institute of Biomedical Engineering, Moscow, Russia. s-sudakov@mtu-net.ru
Papazov
I P
IP
Lyupina
Yu V
YV
Medvedeva
O F
OF
Figurina
I V
IV
Rusakova
I V
IV
D000818:Animals; D001007:Anxiety / Q000209:etiology; D001522:Behavior, Animal; D002110:Caffeine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D012646:Self Administration; D013045:Species Specificity; D013997:Time Factors
D002110:Caffeine; D009020:Morphine