title: [Expression of CDK4 protein in oral carcinogenesis].
abstract: OBJECTIVE
  To study the expression of cyclin dependent kinase 4(CDK4) protein in oral carcinogenesis.
  
  
  METHODS
  An LSAB immunohistochemistry method was applied to 80 cases of paraffine-fixed tissues to study the expression and distribution of CDK4 in normal oral mucosa, oral premalignant lesion (OPL) and oral squamous cell carcinoma.
  
  
  RESULTS
  The overexpression of CDK4 protein was observed in the progression of OPL. Meanwhile, a correlation analysis was applied to investigate the relationship between P16 and CDK4 expression, and the result showed that the coefficient of correlation was 0.813, which was statistically significant.
  
  
  CONCLUSIONS
  The overexpression of CDK4 is involved in the progression of OPL, and there is a positive feedback loop between CDK4 and P16.
authors.affiliation: Department of Oral Medicine, College of Stomatology, West China University of Medical Sciences.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Luo
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Cao
authors.forename: M
authors.initials: M
authors.lastname: Nie
mesh_terms: D051358:Cyclin-Dependent Kinase 4; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D011518:Proto-Oncogene Proteins; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases