Expression of tissue factor is associated with clinical features and angiogenesis in prostate cancer.
BACKGROUND
Tissue factor (TF), the main initiator of blood coagulation, is involved in cancer metastasis and progression. We examined the role of TF on prostate cancer.


METHODS
Immunohistochemical analysis was performed using the anti-TF antibody. Intra-tumoral blood vessels were visualized by staining endothelial cells with CD34 antibody. We examined the expression of TF and the microvessel density (MVD) in 66 biopsy specimens of prostate cancer, in order to investigate the relationship between the expression of TF and the clinicopathology of prostate cancer.


RESULTS
TF antigen was positive in 41 (62%) of the specimens. There were significant differences in TF expression according to the pretreatment prostate specific antigen (PSA) level (p = 0.0193) and bone metastasis (p = 0.0029). MVD was significantly related to bone metastasis (p = 0.0175). TF-positive carcinomas more frequently presented high MVD expressions (p = 0.017) than TF-negative tumors.


CONCLUSIONS
These results suggest that increased angiogenesis associated with TF expression might cause the metastasis and progression of prostate cancer.
Ohta
Shoichiro
S
Department of Urology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan. a0412@ms.toyama-mpu.ac.jp
Wada
Hideo
H
Nakazaki
Takahiro
T
Maeda
Yoshinobu
Y
Nobori
Tsutomu
T
Shiku
Hiroshi
H
Nakamura
Shin
S
Nagakawa
Osamu
O
Furuya
Yuzo
Y
Fuse
Hideki
H
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D013925:Thromboplastin / Q000096:biosynthesis*
D013925:Thromboplastin