[The function of benzol peroxide in the induction of Syrian golden hamster tongue carcinoma by chemical carcinogen].
OBJECTIVE
To testify the function of promoter(benzol peroxide) in the induced tongue carcinogenesis of Syrian golden hamster as well as the function of carcinogen (DMBA).


METHODS
In this study, group 1: 20% benzoyl peroxide in acetone solution was brushed to the right tongue border of Syrian golden hamster, followed by 0.5% 7, 12-dimethybenzanthrancene(DMBA) in acetone, twice a week, lasting 20 weeks. Group 2: 0.5% 7,12-dimethybenzanthrancene(DMBA) in acetone was painted on the right tongue border of golden Syrian hamster in the manner of group 1. Group 3: 20% benzoyl peroxide in acetone solution was used with mentioned methods.


RESULTS
Group 2: showed 90% (27/30) carcinogenesis-rate in tongue of Syrian golden hamster. While it was 100% (30/30) of induced tongue carcinoma and 3/30 lymph node metastasis was found in group 1. No tongue carcinogenesis was found in group 3. The former two groups had the manifestations of hyperplasia of epithelium cell, carcinoma in situ, invasive and cervical lymph node metastatic carcinoma in the process of experiment, but it was 2 weeks shorter in group 1 than that of group 2. Both groups had the same features under eye and light microscope. The samples were high-differentiated squamous cell carcinoma histologically through HE stain.


CONCLUSIONS
This study indicated that benzoyl peroxide could increase carcinogenesis of golden hamster tongue which induced by DMBA. Consideration of promoting agent should be taken in carcinogenesis as well as carcinogen.
Qiu
C
C
College of Stomatology, West China University of Medical Sciences.
Fu
F
F
Gao
Q
Q
Wang
C
C
Wen
Y
Y
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001585:Benzoyl Peroxide; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D004357:Drug Synergism; D008647:Mesocricetus; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D001585:Benzoyl Peroxide