title: Patterns of polymorphism in the MHC class II of a non-passerine bird, the great snipe (Gallinago media).
abstract: The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, the great snipe (Gallinago media). Eleven alleles were found in five sequenced individuals; these come from at least three different loci, but RFLP data suggest that a larger number of genes may be present. For MHC genes, amino acid substitutions followed the, for MHC genes, general pattern of high non-synonymous substitution rates in peptide-binding regions, suggesting that the sequenced alleles may be expressed. The number of genes, lengths of introns and exon sequences of the great snipe MHC seem to be intermediate between those of chicken and passerine birds.
authors.affiliation: Population Biology/Evolutionary Biology Centre, Uppsala University, Norbyv.18D, 752 36 Uppsala, Sweden. robert.ekblom@ebc.uu.se
authors.forename: Robert
authors.initials: R
authors.lastname: Ekblom
authors.forename: Mats
authors.initials: M
authors.lastname: Grahn
authors.forename: Jacob
authors.initials: J
authors.lastname: Höglund
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001717:Birds / Q000235:genetics* / Q000276:immunology; D005091:Exons; D005802:Genes, MHC Class II; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length