title: Effect of omeprazole on plasma zinc levels after oral zinc administration.
abstract: BACKGROUND
  The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption.
  
  
  METHODS
  Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days.
  
  
  RESULTS
  Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p < 0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p < 0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p < 0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p < 0.01).
  
  
  CONCLUSIONS
  Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.
authors.affiliation: Department of Gastroenterology, Ege University School of Medicine, Bornova TR-35100, Izmir, Turkey. ozutemiz@med.ege.edu.tr
authors.forename: A Omer
authors.initials: AO
authors.lastname: Ozutemiz
authors.forename: H Hakan
authors.initials: HH
authors.lastname: Aydin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Isler
authors.forename: Handan Ak
authors.initials: HA
authors.lastname: Celik
authors.forename: Yucel
authors.initials: Y
authors.lastname: Batur
mesh_terms: D000126:Achlorhydria / Q000097:blood* / Q000139:chemically induced; D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D005260:Female; D005744:Gastric Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D015032:Zinc / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism
chemical_list: D015032:Zinc; D009853:Omeprazole