title: Ribosome-lamella complex of leukemic cells in a patient with aggressive NK cell leukemia.
abstract: A 36-year-old male was admitted to the hospital with anemia and leukopenia. A bone marrow specimen revealed the proliferation of leukemic cells with flower-like nuclei observed in adult T-cell leukemia. The leukemic cells were positive for HLA-DR, CD2, CD7, and CD56. A diagnosis of aggressive NK cell leukemia was made, the patient was treated with induction chemotherapy and cord blood stem cell transplantation, and he is well now. Seen with electron microscopy, some leukemic cells had ribosome-lamella complexes (RLC). This is the first reported case of leukemic cells with flower-like nuclei seen with light microscopy and RLC seen with electron microscopy.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Hatsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yokohama
authors.forename: Hideki
authors.initials: H
authors.lastname: Uchiumi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Matsushima
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Karasawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ogawara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
mesh_terms: D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure; D007694:Killer Cells, Natural / Q000648:ultrastructure*; D015458:Leukemia, T-Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008297:Male; D009685:Nuclear Envelope / Q000648:ultrastructure; D012270:Ribosomes / Q000648:ultrastructure