Predicting outcome in hematological stem cell transplantation.
This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-alpha, IFN-gamma, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.
Dickinson
Anne M
AM
University Department Haematology, Tyneside Leukemia Research Laboratory, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK. a.m.dickinson@ncl.ac.uk
Cavet
James
J
Cullup
Hannah
H
Wang
Xiao N
XN
Jarvis
Mark
M
Sviland
Lisbet
L
Middleton
Peter G
PG
D016207:Cytokines / Q000235:genetics; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011110:Polymorphism, Genetic; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D016207:Cytokines