Roles of phospholipase D in apoptosis and pro-survival.
Accumulating evidence has recognized phospholipase D (PLD) as an important element in signal transduction of cell responses, including proliferation and differentiation, However, its role in pro-apoptotic, anti-apoptotic or pro-survival signaling is not well-understood. Involvement of PLD in these signaling mechanisms is considered to differ depending on the cell type and the extracellular stimulus.
Nozawa
Yoshinori
Y
Department of Environmental Cell Responses, Gifu International Institute of Biotechnology, Mitakecho 2193-128, Kanigun, Gifu 505-0116, Japan. nozawa@cc.gifu-u.ac.jp
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015687:Cell Hypoxia; D002460:Cell Line; D002462:Cell Membrane / Q000201:enzymology; D002470:Cell Survival; D004789:Enzyme Activation; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010739:Phospholipase D / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D012333:RNA, Messenger / Q000032:analysis; D015398:Signal Transduction
D020559:Monomeric GTP-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D010739:Phospholipase D; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D012333:RNA, Messenger