[Hyaluronic acid and laminin in patients with ischemic necrosis of femoral head].
To study the course and clinical significance of hyaluronic acid (HA) and laminin(LN), the main components of extracellular matrix in ischemic necrosis of femoral head(INFH), the quantities of HA and LN were measured by radioimmunoassay in 45 patients suffering from INFH with different pathogenesis, and in 30 normal subjects(NS). The results showed that the level of HA in patients with INFH was markedly higher than that of NS group(t = 3.29, P < 0.01). The patients with hormone type INFH had the highest level of HA(t = 3.62, P < 0.01). The level of LN in patient with INFH was significantly higher than that of NS group(t = 2.84, P < 0.01). The increased levels of HA and LN were positively correlated with the development of the disease. These suggest that quantity analysis of HA and LN may be used as a good indicator in early diagnosis and prognosis of INFH.
Luo
N
N
Department of Immunology, General Hospital of Jinan Military Area, Jinan 250031.
Yang
D
D
Fu
Z
Z
Sun
W
W
Chen
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007797:Laminin / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007797:Laminin; D006820:Hyaluronic Acid