title: [Effects of para-aminobenzoic acid (PABA) on growth of Lactobacillus acidophilus].
abstract: OBJECTIVE
  The aim of this study is to examine effects of para-aminobenzoic acid (PABA) on the growth of Lactobacillus acidophilus (L. acidophilus).
  
  
  METHODS
  Different concentrations of PABA (10(-10)-10(-3) g/L) were separately transferred to the modified Carlsson medium. L. acidophilus (ATCC4356) grew in these Carlsson media. All cultures were incubated at 37 degrees C anaerobically in atmosphere of 80% of nitrogen, 10% of hydrogen, and 10% of carbon dioxide for 48 hours. Absorbance values (lambda = 540 nm) of bacterial suspensions were measured using a spectrometer (UV-1601). Colony forming units (CFU) were obtained by growing L. acidophilus in Carlsson media with different concentration of PABA (10(-10)-10(-3) g/L).
  
  
  RESULTS
  Different concentrations of PABA (10(-10)-10(-4) g/L) had different stimulating effects on the growth of L. acidophilus (P < 0.05). But stimulating effects declined, when PABA concentration was 10(-5) g/L, and when the concentration of PABA reached 10(-3) g/L, the stimulating effect disappeared.
  
  
  CONCLUSIONS
  This study indicates PABA stimulates the growth of L. acidophilus, and PABA can promote growth of L. acidophilus.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: B
authors.initials: B
authors.lastname: Guo
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Xiao
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Li
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000254:growth & development; D062366:para-Aminobenzoates
chemical_list: D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid