title: Instantaneous parameter estimation in cardiovascular time series by harmonic and time-frequency analysis.
abstract: Time-frequency distributions, such as smoothed pseudo Wigner-Ville distribution (SPWVD), complex demodulation (CDM), and provide useful time-varying spectral parameter estimators. However, each of these methods has limitations that a joint utilization could largely reduce, due to their interesting complementary features. The aim of this paper is to validate the joint SPWVD-CDM method on synthetic and real cardiovascular time series with normal and reduced variability such as in autonomic blockade or autonomic deficiency. We propose two indexes related to the noise present in the signal and to the dispersion of the power spectrum in order to validate instantaneous parameter estimation. In the low-frequency band, the interpretation of the instantaneous frequency and phase of cardiovascular time-series should be discarded in many real-life situations. Conversely, in the high frequency band, under paced breathing, the reliability of the instantaneous parameters is demonstrated even in conditions of reduced cardiovascular variability.
authors.affiliation: French National Institute for Research in Computer Science and Control (INRIA), Project SOSSA, Bt. 12, BP 105, Le Chesnay 78153, France. alessandro.monti@inria.fr
authors.forename: Alessandro
authors.initials: A
authors.lastname: Monti
authors.forename: Claire
authors.initials: C
authors.lastname: Médigue
authors.forename: Laurence
authors.initials: L
authors.lastname: Mangin
mesh_terms: D000465:Algorithms; D002908:Chronic Disease; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D006333:Heart Failure / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D011187:Posture; D012016:Reference Values; D015203:Reproducibility of Results; D012119:Respiration; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes