title: Balloon angioplasty and stenting of multiple intralobar pulmonary arterial stenoses in adult patients.
abstract: Balloon angioplasty and stent placement for pulmonary arterial stenoses in children are well-established therapies. In contrast, management of isolated peripheral pulmonary arterial stenoses in adults remains relatively unexplored. Four women (ages 18-63 years) with multiple discrete intralobar pulmonary arterial stenoses were treated with balloon angioplasty. Initially, 4-5 stenoses were dilated in each patient. The mean minimum diameter of the stenoses increased from 1.3 to 3.1 mm (P < 0.001), and the mean ratio of right ventricular to aortic systolic pressure decreased from 0.92 to 0.62 (P < 0.05). Each patient had marked symptomatic improvement. However, three patients developed recurrence of symptoms 4-24 months after angioplasty, and two had angiographic evidence of restenosis at previously dilated sites. These restenoses were treated with repeat angioplasty or stent implantation (three stents in each patient). One of these two patients developed near-occlusive restenosis of the stents and had successful bilateral lung transplantation. The other patient had a third catheterization with successful implantation of three additional stents. The third patient with recurrent symptoms died 2 years later, without further intervention. Transcutaneous catheter therapy for multiple intralobar pulmonary arterial stenoses in adults is highly successful acutely, but restenosis is common within several months. For some patients, balloon angioplasty and stent implantation may provide definitive management, while for others these procedures may serve as a bridge to lung transplantation.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of California, San Diego, California, USA. arothman@chsd.org
authors.forename: Abraham
authors.initials: A
authors.lastname: Rothman
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Levy
authors.forename: Mark S
authors.initials: MS
authors.lastname: Sklansky
authors.forename: Paul D
authors.initials: PD
authors.lastname: Grossfeld
authors.forename: William R
authors.initials: WR
authors.lastname: Auger
authors.forename: Gholam H
authors.initials: GH
authors.lastname: Ajami
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Behling
mesh_terms: D000293:Adolescent; D000328:Adult; D000792:Angiography; D000800:Angioplasty, Balloon; D003251:Constriction, Pathologic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D012008:Recurrence; D015607:Stents; D016896:Treatment Outcome