Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors.
Previous work from this laboratory demonstrated that intracerebroventricular (i.c.v.) administration of IgG antibodies directed against selected neuropeptides changed the density of opioid receptors, suggesting that neuropeptides in the CNS can perform a regulatory role. To further test this hypothesis, we administered anticorticotropin (CRF) IgG to rats via the i.c.v. route and measured the density of opioid mu and delta receptors and also beta- and alpha(2)-adrenergic receptors. The results demonstrated that anti-CRF IgG upregulates mu and beta-adrenergic receptors. We conclude that CRF in the cerebrospinal fluid may exert regulatory effects throughout the brain.
Rothman
Richard B
RB
Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. rrothman@intra.nida.nih.gov
Vu
Nga
N
Xu
Heng
H
Baumann
Michael H
MH
Lu
Yi-Feng
YF
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000276:immunology / Q000378:metabolism*; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*
D007074:Immunoglobulin G; D011941:Receptors, Adrenergic; D011957:Receptors, Opioid; D003346:Corticotropin-Releasing Hormone