Mumps outbreak in vaccinated children in Gipuzkoa (Basque Country), Spain.
A mumps outbreak occurred in a group of vaccinated children aged 3-4 years in San Sebastián (Gipuzkoa, Basque Country, Spain) in 2000 during the same period as a revaccination campaign against measles-mumps-rubella (MMR) was performed. The clinical cases were confirmed by viral culture, detection of viral RNA and/or specific IgM. Eighty-eight percent of the children had been vaccinated with the Rubini strain and the remainder with the Jeryl-Lynn strain. The attack rate was 47.9% (35 cases in 73 school-attending children of this age). The outbreak was caused by an H genotype strain of mumps virus which was circulating at the same time as a D genotype strain that caused sporadic cases. By sequencing the small hydrophobic (SH) gene, the strains of the clinical cases were identified as wild-type mumps virus with heterologous genotypes in comparison to the vaccine strains used in our area.
Montes
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Servicio de Microbiologia, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain.
Cilla
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Artieda
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Vicente
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Basterretxea
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D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D015994:Incidence; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009107:Mumps / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013030:Spain / Q000453:epidemiology
D004279:DNA, Viral; D007075:Immunoglobulin M; D022542:Measles-Mumps-Rubella Vaccine; D012367:RNA, Viral