[Preliminary evaluation of microsatellite instability in skin cancers].
Microsatellites of DNA--short, tandem repeat segments dispersed throughout the human genome--probably play a role in carcinogenesis. In this study the presence of microsatellite instability (MSI) was evaluated in skin cancers. Only one specimen (basal cell carcinoma) out of twelve skin cancers exhibited MSI at chromosome 2. MSI was not found in benign skin lesions (seborrhoeic verruca, keratoacanthoma, senile keratosis).
Rucińska
Monika
M
Zakład Onkologii AM w Białymstoku.
Kozłowski
Leszek
L
Pepiński
Witold
W
Skawrońska
Małgorzata
M
Janica
Jerzy
J
Wojtukiewicz
Marek Z
MZ
D002280:Basal Cell Carcinoma / Q000097:blood / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D004273:DNA, Neoplasm / Q000032:analysis*; D005069:Evaluation Studies as Topic; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000097:blood / Q000235:genetics*
D004273:DNA, Neoplasm