[An electrophysiological study of the kainic acid toxicity on cochleas].
OBJECTIVE
The purpose of this study was to investigate the kainic acid (KA) toxicity on cochleas.


METHODS
One microliter KA in the concentration of 60 mM was applied to the round window membrane of guinea pig. The compound action potential (CAP), cochlear microphonic potential (CM) and distortion product otoacoustic emissions (DPOAE) were measured 12 hours after KA was administrated.


RESULTS
CAP was suppressed significantly or abolished after the drug administration, however, the CM and DPOAE almost presented no change.


CONCLUSIONS
The targets of KA toxicity are the primary auditory afferent endings.
Han
S
S
Department of Otorhinolaryngology, Union Hospital, Tongji Medical University, Wuhan 430022.
Kong
W
W
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects*; D004594:Electrophysiology; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid