title: Versatile enantiocontrolled synthesis of (+)-fostriecin.
abstract: Fostriecin, a potent protein phosphatase inhibitor and antitumor agent, has been enantioselectively synthesized in naturally occurring form via a versatile route, which also allows one to secure all possible stereoisomeres of the C1-C13 fragment including the C11 stereocenter and the geometry of the delta 12-double bond.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan. susumi@net.nagasaki-u.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Esumi
authors.forename: Nanako
authors.initials: N
authors.lastname: Okamoto
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors; D011090:Polyenes; D011753:Pyrones; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D004791:Enzyme Inhibitors; D011090:Polyenes; D011753:Pyrones; D010749:Phosphoprotein Phosphatases; C040313:fostriecin