title: Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hyperpyrexia.
abstract: Serum cytokine profiles in patients with Plasmodium vivax malaria who presented with and without hyperpyrexia were compared by a retrospective review of the medical records of the consecutive patients seen at the military hospitals near the demilitarized zone in the Republic of Korea from April 2000 through October 2001. Of 162 male patients studied, 120 (86.4%) presented with hyperpyrexia (i.e., an axillary temperature > or = 40 degrees C). The mean +/- SEM ages of the patients with and without hyperpyrexia were 21.5 +/- 0.14 and 21.9 +/- 0.39 years, respectively (P = 0.33). The mean +/- SEM concentrations of serum interleukin (IL)-6 (379.7 +/- 44.1 pg/mL versus 105.4 +/- 26.8 pg/mL; P = 0.002), IL-10 (583.4 +/- 58.2 pg/mL versus 142.4 +/- 39.7 pg/mL; P = 0.0001), and interferon-gamma (312.6 +/- 33.9 pg/mL versus 112.9 +/- 27.1 pg/mL; P = 0.0001) were significantly higher in patients with hyperpyrexia compared with those without hyperpyrexia. The mean +/- SEM concentrations of serum tumor necrosis factor-alpha were 155.5 +/- 54.5 pg/mL and 109.9 +/- 29.3 pg/mL (P = 0.27) in patients who presented with and without hyperpyrexia, respectively. Further studies are needed to examine whether serum concentrations of these cytokines also parallel their concentrations at the tissue sites of their production and action.
authors.affiliation: Department of Microbiology, Parasitology, Preventive Medicine, Internal Medicine, and Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Seoh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khan
authors.forename: Se-Ho
authors.initials: SH
authors.lastname: Park
authors.forename: Hae-Kyung
authors.initials: HK
authors.lastname: Park
authors.forename: Myong-Heon
authors.initials: MH
authors.lastname: Shin
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Bo-Eun
authors.initials: BE
authors.lastname: Lee
authors.forename: Kwon
authors.initials: K
authors.lastname: Yoo
authors.forename: Ho-Seong
authors.initials: HS
authors.lastname: Han
authors.forename: Sejoong
authors.initials: S
authors.lastname: Oh
authors.forename: Jun-Hwan
authors.initials: JH
authors.lastname: Wi
authors.forename: Chang-Kwon
authors.initials: CK
authors.lastname: Hong
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: Young-A
authors.initials: YA
authors.lastname: Kim
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Park
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005334:Fever / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007723:Korea; D016780:Malaria, Vivax / Q000150:complications / Q000276:immunology*; D008889:Military Personnel; D012189:Retrospective Studies
chemical_list: D016207:Cytokines