Fox odour affects corticosterone release but not hippocampal serotonin reuptake and open field behaviour in rats.
Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. When group-housed SD rats were tested 1 week after a 1-h exposure to TMT, hippocampal 5-HT metabolism, [3H]5-HT reuptake, and [3H]paroxetine binding at the 5-HT transporter remained unchanged. This study questions TMT as a specific predatory stimulus as both butyric acid and TMT increased plasma corticosterone levels whilst leaving intact open field behaviour (at least in group-housed SD rats).
Dias Soares
Danusa
D
INSERM U471-INRA, Institut F. Magendie, Rue Camille Saint Saëns, 33077 Bordeaux, France.
Fernandez
Francesca
F
Aguerre
Sylvie
S
Foury
Aline
A
Mormède
Pierre
P
Chaouloff
Francis
F
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism*; D005589:Foxes / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009419:Nerve Tissue Proteins; D009812:Odorants; D017374:Paroxetine / Q000378:metabolism; D051381:Rats / Q000502:physiology*; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology
D002352:Carrier Proteins; D003345:Corticosterone; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017374:Paroxetine; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D013844:Thiazoles; C411827:2,5-dihydro-2,4,5-trimethylthiazoline; C493232:Slc6a4 protein, rat