[Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum].
Different Sorangium cellulosum strains not only showed diversity in their cell and fruiting body morphologies, but also differences of bio-activities and components of the metabolites. All the Sorangial strains studied in this paper had no activity on Gram-negative bacteria, some were able to repress Gram-positive bacteria. However, all the strains were able to repress growth of fungi and tumor cells strongly and widely. Thin layer chromatography assay of metabolites showed multi-components in the metabolites, and most of them have abilities of repressing fungi and tumor cells in different degrees. Four strains were found to be able to produce compounds with activity of promoting polymerization of microtubule. Based on Rf value on TLC, the bio-active component produced by So33-1 strain was similar to Epothilone A, while that of So81 was much different. The results of this paper suggested that Sorangium cellulosum is a much beneficial resource for screening nature compounds with bio-activities against eukaryotes.
Li
Y
Y
State Key Laboratory of Microbial Technology, College of Life Science, Shandong University, Jinan 250100, China.
Hu
W
W
Wu
B
B
Yan
Z
Z
Chen
Q
Q
D000970:Antineoplastic Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D045744:Cell Line, Tumor; D034261:Epothilones / Q000096:biosynthesis* / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008870:Microtubules / Q000187:drug effects; D009231:Myxococcales / Q000378:metabolism*; D013045:Species Specificity
D000970:Antineoplastic Agents; D034261:Epothilones; C093787:epothilone A