[Clinical observation of TNF-alpha content in nasopharyngeal secretion of patients with nasopharyngeal carcinoma].
OBJECTIVE
To detect the changes of tumor necrosis factor-alpha (TNF-alpha) in nasopharyngeal secretion of patients with nasopharyngeal carcinoma(NPC).


METHODS
The content of TNF-alpha in nasopharyngeal secretion was determined by radioimmunoassay (RIA) in 20 controls, 52 patients with NPC.


RESULTS
The average concentrations of TNF-alpha were (12.95 +/- 4.62) pmol/L in control group, (33.68 +/- 15.13) pmol/L in NPC group and (64.00 +/- 11.57) pmol/L in NPC with necrosis group. The content of TNF-alpha in nasopharyngeal secretion in control group was lower significantly than that of patients with NPC (P < 0.01).


CONCLUSIONS
The level of TNF-alpha in nasopharyngeal secretion of NPC patients was higher than that of normal subjects. To detect the content of TNF-alpha in nasopharyngeal secretion is a useful test for the study and diagnosis of NPC.
Cui
D
D
Department of Otolaryngology, Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001.
Zhao
Y
Y
Deng
Y
Y
Luo
G
G
Su
M
M
Chen
X
X
D000328:Adult; D000368:Aged; D012634:Bodily Secretions / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha