title: Systemic Apophysomyces elegans after trauma: case report and literature review.
abstract: We present a case of systemic fungal infection caused by Apophysomyces elegans in a 50-year-old patient who developed a progressive skin lesion after a motor vehicle crash. Histopathological and mycological examination of the surgical sample showed non-septated hyphae characteristic of mucoraceous fungi. Despite extensive surgical debridement, and parenteral administration of amphotericin B, the patient died of multi-organ failure. Autopsy findings suggested systemic involvement. The fungi recovered from culture had non-apophyseal and globose sporangi, and branched sporaniophores and was identified as Apophysomyces elegans.
authors.affiliation: Division of Surgical Infectious Disease, University of Texas Medical Branch, Galveston, Texas 77550-1115, USA. juewang@utmb.edu
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Charles M
authors.initials: CM
authors.lastname: Harvey
authors.forename: Jason H
authors.initials: JH
authors.lastname: Calhoun
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yin
authors.forename: Jon T
authors.initials: JT
authors.lastname: Mader
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009090:Mucorales; D009091:Mucormycosis / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D009102:Multiple Organ Failure / Q000209:etiology; D014946:Wound Infection / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B