title: Analysis of reaction products of morphine and codeine with hydrogen peroxide by high-performance liquid chromatography/mass spectrometry.
abstract: Changes in the chemical structures of morphine and codeine in the presence of hydrogen peroxide, a major component of hair dye and decolorant treatments, were examined with high-performance liquid chromatography/mass spectrometry (LC/MS). A mixture of morphine and hydrogen peroxide solution, after incubation at 39 degrees C for 24 h, produced two reaction products (hydroxymorphines). When codeine was used in place of morphine, one reaction product (hydroxycodeine) was produced, in which the benzene ring was hydroxylated.
authors.affiliation: Forensic Science Laboratory, Ishikawa Prefectural Police Headquarters, Hirosaka, Kanazawa 920-8553, Japan. tanakase@plum.ocn.ne.jp
authors.forename: Seishi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Reiko
authors.initials: R
authors.lastname: Iio
authors.forename: Satoshi
authors.initials: S
authors.lastname: Chinaka
authors.forename: Nariaki
authors.initials: N
authors.lastname: Takayama
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003061:Codeine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D009020:Morphine / Q000737:chemistry*
chemical_list: D009020:Morphine; D006861:Hydrogen Peroxide; D003061:Codeine