[Experimental evaluation of immunotoxicity of olipifat].
The paper presents our data on the influence of Olipifat on the mass and cell patterns of the immune system organs, phagocytic activity of macrophages, number of antibody-producing B-lymphocytes and immune rosette-forming T-lymphocytes. Olipifat showed no immunotoxic characteristics; it stimulated T-system immunity as evidenced by a significant increase in the number of immune rosette-forming T-lymphocytes in mice after injection of 100 or 50 mg/kg.
Belokhvostova
A T
AT
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Okulov
V B
VB
Potapenkova
L S
LS
Reztsova
V V
VV
Filov
V A
VA
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D007107:Immune System / Q000187:drug effects; D008031:Lignin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
C413426:olipifat; D008031:Lignin