title: Simulation of waves in calcium models with 3D spherical geometry.
abstract: Waves of calcium ions are present in fertilized eggs of many species. Models for pulse and tidal wave propagation have usually been studied in one or two spatial coordinates only. We examine in three spatial coordinates some established models, based on Ca(2+)-induced Ca(2+)-release from both (assumed) continuously or heterogeneously distributed stores of endoplasmic reticulum (ER) through channels activated by inositol triphosphate (IP(3)). With continuous IP(3) distribution decreasing radially towards the interior, we obtain concave pulse shapes for waves penetrating the interior. Concave waves are also recorded in systems with ER confined to distributions of small spheres (microdomains) inside the cell, which we simulate for front waves (tides) in bistable systems.
authors.affiliation: Department of Chemistry C116, H C Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen, Denmark. axhun@osc.kiku.dk
authors.forename: Axel
authors.initials: A
authors.lastname: Hunding
authors.forename: Mads
authors.initials: M
authors.lastname: Ipsen
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D003198:Computer Simulation; D004721:Endoplasmic Reticulum / Q000502:physiology; D007295:Inositol Phosphates / Q000502:physiology; D008954:Models, Biological; D015053:Zygote / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D007295:Inositol Phosphates; D002118:Calcium