Triton X-100-stabilized "oil-in-water" emulsions as suitable media for alkalimetric determination of hydrophobic organic acids.
The protolytic properties of fat row carbonic acids in Triton X-100-stabilized "oil-in-water" (O/W) emulsions were studied. The differential influence of emulsions on the force of acids was shown to depend on the length of the hydrocarbon radical. The conditions for separate alkalimetric determinations of acids with different hydrophobicities in their mixtures using emulsions stabilized by non-ionic surfactant were suggested. The procedure for the determination of 4-chloro- N-(2-furilmethyl)-5-sulfamoylanthranilic acid (furosemide) main substance content in pharmaceuticals using Triton X-100-stabilized emulsion was proposed.
Kulichenko
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Analytical Chemistry Department, Taras Shevchenko Kyiv University, Volodymyrska Str. 61, Ukraine. kulichenko@mail.univ.kiev.ua
Shevchenko
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