Statin-induced myositis migrans.
Muscle related side effects of statins might be more frequent than once considered. Without affecting CK, they appear in various forms. Here, for the first time, we describe a new appearance we call "Statin-induced myositis migrans" in a 74-year-old female. Symptoms appeared more during the day and were not related to exercise. They were seen after simvastatin, pravastatin and--most intensively--after atorvastatin, but not on lovastatin, which the patient took for about 7 years without any problem. The clinical consequence (to withdraw the drug or not) of these milder statin side effects are discussed.
Sinzinger
Helmut
H
Wilhelm Auerswald Atherosclerosis Research Group (ASF), Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis (ATHOS), Vienna, Austria. helmut.sinzinger@univie.ac.at
D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D000069059:Atorvastatin; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008148:Lovastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D009220:Myositis / Q000139:chemically induced*; D017035:Pravastatin / Q000008:administration & dosage / Q000009:adverse effects*; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects*; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D011758:Pyrroles; D008148:Lovastatin; D000069059:Atorvastatin; D019821:Simvastatin; D017035:Pravastatin