Not just any T cell receptor will do.
Although our structural understanding of T cell recognition has rapidly evolved due to recent crystallographic results, the reality is that detailed answers to many of the most fundamental questions still remain elusive. In this issue, high-resolution insight into the phenomenon of TCR chain bias takes down another brick from the wall.
Bankovich
Alexander J
AJ
Department of Microbiology and Immunology, Department of Structural Biology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305, USA.
Garcia
K Christopher
KC
D001665:Binding Sites; D022801:Complementarity Determining Regions; D015395:Histocompatibility Antigens Class I / Q000737:chemistry; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology
D022801:Complementarity Determining Regions; D015395:Histocompatibility Antigens Class I; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell