title: Intercaudate nucleus ratio as a linear measure of brain atrophy in multiple sclerosis.
abstract: Intercaudate nucleus ratio (ICR) is a linear measure of brain atrophy that does not require software application and is independent of image acquisition techniques. The authors examined the relationship between ICR and disability in 190 patients with MS. The results show that ICR correlates with Expanded Disability Status Scale score (r = 0.67; p = 0.0001) and disease duration (r = 0.32; p < 0.01). Intercaudate ratio appears to be a reliable and reproducible linear measure of brain atrophy and correlates with disability and disease duration in MS.
authors.affiliation: Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: C
authors.initials: C
authors.lastname: Caon
authors.forename: M
authors.initials: M
authors.lastname: Zvartau-Hind
authors.forename: W
authors.initials: W
authors.lastname: Ching
authors.forename: R P
authors.initials: RP
authors.lastname: Lisak
authors.forename: A C
authors.initials: AC
authors.lastname: Tselis
authors.forename: O A
authors.initials: OA
authors.lastname: Khan
mesh_terms: D000328:Adult; D001284:Atrophy / Q000150:complications / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000150:complications / Q000175:diagnosis*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012737:Sex Factors