title: Regional cerebral blood flow changes during visually induced subjective sadness in healthy elderly persons.
abstract: This study examined regional cerebral blood flow (rCBF) changes associated with visually induced sad affect in healthy elderly persons. Subjects viewed sadness-laden, happiness-laden, and emotionally neutral image sets while rCBF was recorded using [(15)O] water PET. The sad image set included human faces and scenery/objects ("scenes"). To control for secondary sensory processing, the neutral and happy comparison sets included exclusively either human faces or scenes. During the sad condition, the ventral prefrontal and temporal cortices were more active compared with happy and neutral scenes conditions and the thalamus was more active compared with happy and neutral faces conditions. Ventral prefrontal cortex and thalamus were associated with processing of sad visual stimuli, whether compared with neutral or happy stimuli. The specific findings associated with sad affect were contingent on the comparison stimuli content (scenes or human faces), not affect (i.e., comparison with neutral or happy conditions).
authors.affiliation: Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA. sergio-paradiso@uiowa.edu
authors.forename: Sergio
authors.initials: S
authors.lastname: Paradiso
authors.forename: Robert G
authors.initials: RG
authors.lastname: Robinson
authors.forename: Laura L
authors.initials: LL
authors.lastname: Boles Ponto
authors.forename: G Leonard
authors.initials: GL
authors.lastname: Watkins
authors.forename: Richard D
authors.initials: RD
authors.lastname: Hichwa
mesh_terms: D000339:Affect / Q000502:physiology*; D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D005260:Female; D006240:Happiness; D006801:Humans; D007092:Imagination / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000098:blood supply / Q000000981:diagnostic imaging; D010364:Pattern Recognition, Visual / Q000502:physiology; D017397:Prefrontal Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D012016:Reference Values; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D013788:Thalamus / Q000098:blood supply / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed