Alleviation of pre-exposure to low-dose 16O8+ ion on mouse testicular histological damage induced by subsequent high-dose irradiation.
The testes of the B6C3F1 hybrid strain mice were irradiated with 0.05 Gy of 16O8+ ion as the pre-exposure dose (D1), and were then irradiated with 2 Gy of 16O8+ ion as challenging radiation dose (D2) at 4 h after per-exposure. Testicular morphology was observed by light microscope at 35th day after radiation. The results showed that irradiation of mouse testes with 2 Gy of 16O8+ ion significantly impaired, mainly reduction of tubule diameter and decrease or loss of germ cells in various developing stages, especially spermatogenic elements. Pre-exposure to a low-dose (0.05 Gy) of 16O8+ ion significantly alleviated above mentioned damage on testicular morphology induced by subsequent a high-dose (2 Gy) radiation.
Zhang
H
H
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000
Zhang
X
X
Zheng
R L
RL
Gao
Q X
QX
Wei
Z Q
ZQ
Li
W J
WJ
Chen
W Q
WQ
Liang
J P
JP
Han
G W
GW
Huang
T
T
Xie
H M
HM
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007477:Ions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013737:Testis / Q000473:pathology / Q000528:radiation effects*
D007477:Ions; D010100:Oxygen