title: Excessive expression of the scavenger receptor class A type I can significantly affect the serum lipids.
abstract: Scavenger receptor (SR) is characterized by its ability to bind negatively charged macromolecules, particularly the modified lipoproteins that are pertinent to the development of vascular disease. To determine the role of excessive scavenger receptor A in the serum lipoprotein metabolism, transgenic mice lines with mouse scavenger receptor A gene type I (SR-AI) under the control of human SR-AI enhancer and metallothionein gene promotor were established. After zinc induction, the expression of SR-AI in transgenic mice was a little higher than the controls, but the serum lipids levels were significantly different from the controls, especially the cholesterol. These results demonstrated that overexpression of SR-AI significantly affected the serum lipids levels.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Liu
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Wen-Ji
authors.initials: WJ
authors.lastname: Dong
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Feng
authors.forename: Chih-Chuan
authors.initials: CC
authors.lastname: Liang
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D018955:CD36 Antigens / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008055:Lipids / Q000097:blood*; D051379:Mice; D008822:Mice, Transgenic; D010957:Plasmids / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051117:Scavenger Receptors, Class A; D014280:Triglycerides / Q000097:blood
chemical_list: D018955:CD36 Antigens; D008055:Lipids; D051117:Scavenger Receptors, Class A; D014280:Triglycerides; D012313:RNA; D004247:DNA; D002784:Cholesterol