title: Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis.
abstract: Calprotectin has been proposed as a useful marker of inflammatory bowel disease in children. We did a pilot study to establish whether it can be used to aid diagnosis of necrotising enterocolitis in preterm infants. Patients with clinical features of necrotising enterocolitis had raised faecal calprotectin concentrations at the time of diagnosis compared with matched controls (288.4 mg/L [SD 49.1] and 98.0 mg/L [60.6], respectively; p=0.0006). Faecal calprotectin might be a useful marker of gastrointestinal mucosal inflammation in neonates.
authors.affiliation: Department of Paediatric Surgery, Bristol Royal Hospital for Sick Children, BS2 8BJ, Bristol, UK. danderosier@doctors.org.uk
authors.forename: Daniel
authors.initials: D
authors.lastname: Carroll
authors.forename: Anthony
authors.initials: A
authors.lastname: Corfield
authors.forename: Richard
authors.initials: R
authors.lastname: Spicer
authors.forename: Pamela
authors.initials: P
authors.lastname: Cairns
mesh_terms: D016022:Case-Control Studies; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D008297:Male
chemical_list: D039841:Leukocyte L1 Antigen Complex