[Influence of dextran 40 and dextran 70 on the adhesion of erythrocytes to endothelial cells].
Adopting the flow chamber realtime microrecordation system, we studied the dynamic effects of dextran 40(DX40) and dextran 70(DX70) on the adhesion of erythrocytes to monolayer of cultured human umbilical vein endothelial cells (HUVEC). The results demonstrated that erytherocytes pretreated with DX40 adhered to HUVEC less than the erythrocytes of the control group did, but DX70 increased the number of erythrocytes adhering to HUVEC. The higher the concentration of DX70 was, the more the erythrocytes pretreated with DX70 adhered to HUVEC. When shear stress increased, the decrease rate of the number of erythrocytes (pretreated with DX70) adhering to HUVEC declined with the increase of DX70 concentration. These indicate that DX40 as an expander of blood plasma is better than DX70.
Huang
X
X
Analytical Test Center, West China University of Medical Sciences, Chengdu 610041.
Chen
H
H
Wang
L
L
Lin
Y
Y
D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D003911:Dextrans / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology*; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D014471:Umbilical Veins / Q000166:cytology
D003911:Dextrans