Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients.
We investigated whether a different pattern of HLA-specific inhibitory natural killer receptor (iNKR) expression on peripheral blood mononuclear cells (PBMC) of long-term non-progressor (LTNP) patients explained their benign course of HIV-1 infection. The surface expression of p70, p140 and CD94/NKG2A in their CD3+CD8+ PBMC was comparable to that of uninfected donors. The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients.
Costa
Paola
P
Dipartimento di Medicina Interna, University of Genova, Genoa, Italy.
Rusconi
Stefano
S
Fogli
Manuela
M
Mavilio
Domenico
D
Murdaca
Giuseppe
G
Puppo
Francesco
F
Mingari
Maria Cristina
MC
Galli
Massimo
M
Moretta
Lorenzo
L
De Maria
Andrea
A
D000328:Adult; D003602:Cytotoxicity, Immunologic; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D011971:Receptors, Immunologic / Q000097:blood*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014407:Tumor Cells, Cultured
D011971:Receptors, Immunologic