title: [Effects of chitin and chitosan on degradation of DL-polylactide in vitro].
abstract: The authors assessed the variations of pH-values of the physiological saline used for in vitro degradation tests of DL-Polylactide (DL-PLA)/chitin and DL-PLA/chitosan composites and DL-PLA. The weight-loss rations, the appearance and morphology of the tested specimens, and the molecular weights of DL-PLA in composites and pure DL-PLA were alse investigated. The results showed that both chitin and chitosan had significant inhibitory effects on the degradation of DL-PLA, and the effect of chitosan was stronger than that of chitin. A discussion on the mechanism of such inhibition is presented.
authors.affiliation: Institute of Polymer Science, Zhongshan University, Guangzhou 510275.
authors.forename: K
authors.initials: K
authors.lastname: Liao
authors.forename: F
authors.initials: F
authors.lastname: Tang
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: Z
authors.initials: Z
authors.lastname: Lu
authors.forename: H
authors.initials: H
authors.lastname: Huang
mesh_terms: D001672:Biocompatible Materials; D001673:Biodegradation, Environmental / Q000187:drug effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D002686:Chitin; C033616:poly(lactide)