title: New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.
abstract: Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Olimjon K
authors.initials: OK
authors.lastname: Khodzhimatov
authors.forename: Ozodbek A
authors.initials: OA
authors.lastname: Ashurmetov
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D004224:Diterpenes; D014344:Trypanocidal Agents