Selected aspects of endocrine pharmacology of the aging male.
This minireview explores the endocrinology and the clinical consequences of age-related hypogonadism (hypotestosteronemia). In addition, pharmacological and clinical applicability of new androgen formulations is described briefly. Other topics include selective androgen receptor modulators, non-feminizing estrogens, and the possible use of selective aromatase modulators. Finally, a theoretical concept of hormone displacement (i.e. excessive hormone production) is introduced using cortisol as an example.
Oettel
Michael
M
Jenapharm, Otto-Schott-Strasse 15, 07743 Jena, Germany. michael.oettel@jenapharm.de
Hübler
Doris
D
Patchev
Vladimir
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001141:Aromatase / Q000378:metabolism; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D020249:Hormone Replacement Therapy; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007006:Hypogonadism / Q000188:drug therapy* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism* / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D004967:Estrogens; D020738:Leptin; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D001141:Aromatase; D006854:Hydrocortisone