Detection of gene expression pattern in the early stage after spinal cord injury by gene chip.
OBJECTIVE
To study the changes of the gene expression pattern of spinal cord tissues in the early stage after injury by DNA microarray (gene chip).


METHODS
The contusion model of rat spinal cord was established according to Allen's falling strike method and the gene expression patterns of normal and injured spinal cord tissues were studied by gene chip.


RESULTS
The expression of 45 genes was significantly changed in the early stage after spinal cord injury, in which 22 genes up-regulated and 23 genes down-regulated.


CONCLUSIONS
The expression of some genes changes significantly in the early stage after spinal cord injury, which indicates the complexity of secondary spinal cord injury.
Liu
Cheng-long
CL
Department of Orthopedics, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. lclong@mail.china.com
Jin
An-min
AM
Tong
Bin-hui
BH
D000818:Animals; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D016762:Genes, fos / Q000235:genetics; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000235:genetics*; D015854:Up-Regulation