title: Integration of chemical and biochemical analysis systems into a glass microchip.
abstract: This review focuses on the integration of chemical and biochemical analysis systems into glass microchips for general use. By combining multiphase laminar flow driven by pressure and micro unit operations, such as mixing, reaction, extraction and separation, continuous-flow chemical processing systems can be realized in the microchip format, while the application of electrophoresis-based chip technology is limited. The performances of several analysis systems were greatly improved by microchip integration because of some characteristics of microspace, i.e., a large specific interface area, a short molecular diffusion time, a small heat capacity and so on. By applying these concepts, several different analysis systems, i.e., wet analysis of cobalt ion, multi-ion sensor, immunoassay, and cellular analysis, were successfully integrated on a microchip. These microchip technologies are promising for meeting the future demands of high-throughput chemical processing.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
authors.forename: Kiichi
authors.initials: K
authors.lastname: Sato
authors.forename: Akihide
authors.initials: A
authors.lastname: Hibara
authors.forename: Manabu
authors.initials: M
authors.lastname: Tokeshi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hisamoto
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kitamori
mesh_terms: D015374:Biosensing Techniques; D005898:Glass; D008904:Miniaturization