Renal impairment in patients with ovarian cancer.
OBJECTIVE
To investigate the prevalence of renal impairment in patients with ovarian cancer at the time of the diagnosis.


METHODS
Creatinine clearance was estimated according to Cockcroft and Gault (C&G Ccr), glomerular filtration rate (GFR) was determined as renal clearance of 99mTc-DTPA, and renal ultrasound was performed in 60 consecutive patients with newly diagnosed ovarian cancer.


RESULTS
A 28% of the total population studied had a GFR <60 ml/min/1.73 m(2). A moderate/severe dilation of the upper urinary tract was found in 12% of patients. The length of kidneys ranged between 9.0 and 13.5 cm, and a statistically significant correlation was found between kidney length and values of GFR.


CONCLUSIONS
A reduction in renal function and a moderate to severe dilation of upper urinary tract frequently occur in patients with ovarian cancer at the time of the diagnosis.
Donadio
Carlo
C
Department of Internal Medicine, Division of Nephrology, University of Pisa, I-56100, Pisa, Italy. cd.donadio@med.unipi.it
Lucchesi
Annalisa
A
Ardini
Michela
M
Cosio
Stefania
S
Gadducci
Angiolo
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications*; D014463:Ultrasonography
D003404:Creatinine