title: Influence of human leukocyte antigen in the pathogenesis of Ménière's disease in the South Korean population.
abstract: In order to study the associations of Ménière's disease (MD) with human leukocyte antigen (HLA) alleles in the South Korean population, we examined the distribution of HLA class I and II alleles in 39 MD patients and 199 healthy controls. The frequencies of HLA-Cw*0303 (relative risk (RR) = 2.5; p < 0.02) and -Cw*0602 (RR = 3.7; p < 0.03) were significantly increased in patients with MD compared to controls. However, HLA-B44 (RR = 0.2, p < 0.004) and -Cw*0102 (RR = 0.3; p < 0.03) were significantly decreased in patients compared to controls. When the association between hearing level and the presence of HLA alleles was evaluated, the frequencies of HLA-B13 (RR = 7.4; p < 0.004), -B39 (RR = 45.7; p < 0.003), -Cw*0303 (RR = 4.5; p < 0.02) and -Cw*0602 (RR = 6.5; p < 0.02) were significantly increased and those of -B44 (RR = 0.1; p < 0.02) and -Cw*0102 (RR = 0.1; p < 0.03) were significantly decreased in MD patients with hearing losses (stages II-IV) compared to controls. The frequency of HLA-B13 was significantly higher in MD patients with hearing loss (stages II-IV) than in those with normal hearing (stage I). In terms of HLA-DRB1, -DQA1 and -DQB1 allele frequencies, a significantly higher frequency of DRB1*15 was seen in the patients (RR = 2.4; p < 0.03). These results suggest that some HLA alleles may be a useful genetic marker for predicting prognosis in South Korean patients with MD.
authors.affiliation: Department of Otolaryngology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Sang W
authors.initials: SW
authors.lastname: Yeo
authors.forename: Shi-Nae
authors.initials: SN
authors.lastname: Park
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Jeon
authors.forename: Heung-Youp
authors.initials: HY
authors.lastname: Lee
authors.forename: Chul-Woo
authors.initials: CW
authors.lastname: Pyo
authors.forename: Tai-Gyu
authors.initials: TG
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000150:complications; D006801:Humans; D007723:Korea; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D008875:Middle Aged
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006681:HLA-D Antigens