Drug induced nightmares--an etiology based review.
OBJECTIVE
Recent clinical trials have included patient complaints of nightmares as a category of reportable medication side effects. This study integrates that data into current experimental and theoretical research of drug effects that may alter dreaming and nightmares. The objective is to provide a clinical and theoretical framework useful in categorizing the potential and reported drug effects on nightmares.


METHODS
This study reviews case reports and clinical trials that have reported nightmares or alterations in dreaming occurring secondary to medication usage. These data are analysed as to the probability of the drug/nightmare association, and integrated into current electrophysiological and neurochemical theories of dreaming and nightmares.


RESULTS
Pharmacological agents affecting the neurotransmitters norepinephrine, serotonin and dopamine are clearly associated with patient reports of nightmares. Agents affecting immunological response to infectious disease are likely to induce nightmares in some patients. A possible association exists between reports of nightmares and agents affecting the neurotransmitters acetylcholine, GABA and histamine, as well as for some anesthetics, antipsychotics and antiepileptic agents.


CONCLUSIONS
By utilizing our current experimental and theoretical knowledge base, the potential etiology of a majority of reported drug effects on nightmares can be classified. These data support current neurochemical theories of dreaming, as well as suggesting that the biochemical basis for dreaming and nightmare induction may be more complex than generally suggested.
Pagel
J F
JF
Parkview Neurological Institute, University of Colorado Medical School, 1619 North Greenwood, Pueblo, Colorado 81003, USA. pueo34@juno.com
Helfter
P
P
D015984:Causality; D002986:Clinical Trials as Topic; D003625:Data Collection / Q000379:methods; D004325:Dreams / Q000187:drug effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D018377:Neurotransmitter Agents / Q000009:adverse effects
D018377:Neurotransmitter Agents