title: Expanding the organismal scope of proteomics: cross-species protein identification by mass spectrometry and its implications.
abstract: Due to the limited applicability of conventional protein identification methods to the proteomes of organisms with unsequenced genomes, researchers have developed approaches to identify proteins using mass spectrometry and sequence similarity database searches. Both the integration of mass spectrometry with bioinformatics and genomic sequencing drive the expanding organismal scope of proteomics.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Liska
authors.forename: Andrej
authors.initials: A
authors.lastname: Shevchenko
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D023281:Genomics; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D010802:Phylogeny; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification*; D040901:Proteomics / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D016415:Sequence Alignment; D013045:Species Specificity
chemical_list: D011506:Proteins