title: A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
abstract: BACKGROUND
  Our understanding of genes that predispose to essential hypertension is poor.
  
  
  METHODS
  A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).
  
  
  RESULTS
  There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.
  
  
  CONCLUSIONS
  We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, USA. koustubh.ranade@bms.com
authors.forename: Koustubh
authors.initials: K
authors.lastname: Ranade
authors.forename: David
authors.initials: D
authors.lastname: Hinds
authors.forename: Chao Agnes
authors.initials: CA
authors.lastname: Hsiung
authors.forename: Lee-Ming
authors.initials: LM
authors.lastname: Chuang
authors.forename: Mau-Song
authors.initials: MS
authors.lastname: Chang
authors.forename: Ying-Tsung
authors.initials: YT
authors.lastname: Chen
authors.forename: Robert
authors.initials: R
authors.lastname: Pesich
authors.forename: Joan
authors.initials: J
authors.lastname: Hebert
authors.forename: Yii-Der I
authors.initials: YD
authors.lastname: Chen
authors.forename: Victor
authors.initials: V
authors.lastname: Dzau
authors.forename: Richard
authors.initials: R
authors.lastname: Olshen
authors.forename: David
authors.initials: D
authors.lastname: Curb
authors.forename: David
authors.initials: D
authors.lastname: Botstein
authors.forename: David R
authors.initials: DR
authors.lastname: Cox
authors.forename: Neil
authors.initials: N
authors.lastname: Risch
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007564:Japan / Q000208:ethnology; D008126:Lod Score; D008875:Middle Aged