title: Alterations in Na+/H+ exchanger and Na+/HCO3- cotransporter immunoreactivities within the gerbil hippocampus following seizure.
abstract: In this study, a chronological and comparative analysis of the immunoreactivities of Na(+)/H(+) exchanger 1 (NHE1), Na(+)/HCO(3)(-) cotransporter (NBC) and Na(+)/Ca(2+) exchanger (NCE) was conducted in order to identify the effects of spontaneous seizure on their protein expression levels using the gerbil model. The distribution of NHE1 and NBC immunoreactivity in the hippocampus of seizure-resistant (SR) gerbils was similar to that observed in the pre-seizure group of seizure-sensitive (SS) gerbils. From 30 min to 3 h after the onset of the seizure, both NHE1 and NBC immunoreactivities were elevated in the hippocampus, as compared to the pre-seizure group of SS gerbils. At 6 h postictal, these immunoreactivities in the hippocampus had reduced to the pre-seizure level. However, NCE immunoreactivity within the hippocampus was unaltered. These findings suggest that the changes in both NHE1 and NBC immunoreactivity within the hippocampus following seizure may affect tissue excitability and play a role in the reduction of the seizure activity in the gerbil.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea. tckang@hallym.ac.kr
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: In-Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Jae Chun
authors.initials: JC
authors.lastname: Bae
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D012640:Seizures / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000276:immunology / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000276:immunology / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D027982:Sodium-Bicarbonate Symporters; D019831:Sodium-Calcium Exchanger; D017923:Sodium-Hydrogen Exchangers; C069139:growth factor-activatable Na-H exchanger NHE-1