[A comparative morphometrical study on development of anterior septonasal accessory organs in the cleft palate mice].
OBJECTIVE
The aim of this study was to investigate whether cleft palate is associated with the mal-development of the vomer, Jacobson's organ and para-septal cartilage.


METHODS
Sixty craniomaxillary complexes, which came from 30 pairs of trisomy 18 with cleft palate (Ts + CP) and euploid mouse fetuses were precisely orientated in the coronal plane, and serially sectioned at 7 microns thickness. With the aid of computer imaging analysis system the vomer in coronal and sagittal direction, Jacobson's organ and para-septal cartilage in the boundary plane of the primary and secondary palate were measured and compared quantitatively.


RESULTS
The hard tissues (including the vomer and para-septal cartilage) of the anterior nasal septum in Ts + CP foetuses show serious developmental hypoplasia, however, the Jacobson's organ had no significant different between the cleft and non-cleft samples.


CONCLUSIONS
Development hypoplasia of these hard tissues may be more closely related with the autosomal trisomic condition more than the cleft palate.
Cai
Z
Z
Department Oral and Maxillofacial Surgery, Peking University School of Stomatology.
von Domarus
H
H
Engel
E
E
D000818:Animals; D002356:Cartilage / Q000196:embryology*; D002508:Cephalometry; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D008297:Male; D051379:Mice; D009300:Nasal Septum / Q000196:embryology*; D014314:Trisomy; D019147:Vomeronasal Organ / Q000196:embryology*