title: [Comparative studies on activities on antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2000). III. Secular changes in susceptibility].
abstract: The bacteria (Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa) isolated from patients diagnosed as having urinary tract infections (UTIs) in 10 institutions in Japan were supplied between August 2000 and July 2001. Then, the susceptibilities of these bacteria to various antimicrobial agents were examined, and the results were compared with those obtained between 1992 and 1999. Comparison was made by classifying strains isolated from patients into those in uncomplicated UTIs and those in complicated UTIs (including with or without indwelling catheter). E. faecalis showed good susceptibility to ampicillin (ABPC) and imipenem (IPM), and the MIC90s were 2 micrograms/ml. Also, E. faecalis showed good susceptibility to vancomycin (VCM). However, the MIC90, which was 2 micrograms/ml between 1992 and 1999, rose to 4 micrograms/ml in patients with complicated UTIs because the strains inhibited at 4 micrograms/ml increased more than before. The low susceptibility of S. aureus to arbekacin (ABK) in complicated UTIs, as shown in 1998 and 1999, recovered in 2000, and no strains inhibited at > or = 4 micrograms/ml were detected. E. coli showed good susceptibility to CTM (MIC90: 0.25-0.5 microgram/ml) and CZOP (MIC90: < or = 0.125 microgram/ml) and was not resistant to those. E. coli also showed good susceptibility to the other drugs except to penicillins. Decreases in susceptibility of E. coli to quinolones, ciprofloxacin (CPFX), and sparfloxacin (SPFX) were observed in the patients with complicated UTIs. The susceptibility of Klebsiella spp. to all drugs did not significantly change in 2000 and was generally good except to penicillins. Although the susceptibility of P. aeruginosa to carbapenems was notable, the MIC90 went up from 4 micrograms/ml to 16 micrograms/ml in complicated UTIs compared with those observed in the previous year.
authors.affiliation: Department of Urology, Sapporo Medical University, School of Medicine.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kumamoto
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Takaoki
authors.initials: T
authors.lastname: Hirose
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsukawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Yasuharu
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authors.lastname: Kunishima
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujime
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Fujita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ogihara
authors.forename: Kei
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Jun
authors.initials: J
authors.lastname: Igari
authors.forename: Shiro
authors.initials: S
authors.lastname: Shigeta
authors.forename: Toyoko
authors.initials: T
authors.lastname: Oguri
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Fusako
authors.initials: F
authors.lastname: Kashitani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Imafuku
authors.forename: Masaru
authors.initials: M
authors.lastname: Murai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ooe
authors.forename: Mineko
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchida
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Oka
authors.forename: Masaya
authors.initials: M
authors.lastname: Kitamura
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Takano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Seiji
authors.initials: S
authors.lastname: Matsuda
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Toshinari
authors.initials: T
authors.lastname: Furuhama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.forename: Koichi
authors.initials: K
authors.lastname: Monden
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tomono
authors.forename: Siho
authors.initials: S
authors.lastname: Aoki
authors.forename: Chikako
authors.initials: C
authors.lastname: Mochida
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000892:Anti-Infective Agents, Urinary