title: Tadpole skin dies autonomously in response to thyroid hormone at metamorphosis.
abstract: Transgenic tadpoles that express a dominant negative thyroid hormone (TH) receptor specifically in their skin undergo normal metamorphosis, with one exception: they retain a larval epidermis over the developing adult epithelium. TH-induced death of the tadpole epidermis is inhibited by the dominant negative TH receptor whereas the TH-induced response of the neighboring fibroblasts and the cells that form the adult skin occur normally. Therefore death of the tadpole skin is a direct and cell autonomous target of TH, and its protection has no detectable influence on TH-induced changes of other cell types.
authors.affiliation: Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Schreiber
authors.forename: Donald D
authors.initials: DD
authors.lastname: Brown
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007814:Larva / Q000502:physiology*; D008675:Metamorphosis, Biological; D012879:Skin Physiological Phenomena; D013963:Thyroid Hormones / Q000502:physiology*; D014982:Xenopus laevis / Q000254:growth & development*
chemical_list: D013963:Thyroid Hormones