Adult worms of the rodent intestinal nematode, Strongyloides venezuelensis, successfully invade chick intestinal mucosa.
In order to study the mucosal invasion of a rodent intestinal nematode in bird intestine, chicks were infected with the intestinal nematode of rodents, Strongyloides venezuelensis, by subcutaneous larva inoculation and adult worm implantation. No evidence was obtained for larvae reaching the lungs or the intestine after infective larva inoculation. Adult worms implanted in the small intestine invaded the mucosa and remained there at least for 24 h, whereas those implanted in the caecum were trapped by mucus, and did not invade the mucosa. Mucosal invasion of adult worms in the small intestine was confirmed by histological examination. The number of adult worms in the intestinal mucosal tissue dropped rapidly within the first 24 h, which was associated with infiltrating granulocytes around the worms. The present study suggests that S. venezuelensis adult worms are able to invade the intestinal tissue of chicks, which do not belong to the vertebrate class of its normal definitive host, but that they are eliminated rapidly by mucosal defense system of the bird.
Maruyama
Haruhiko
H
Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences, Kawasumi-1, Mizuho, Nagoya 467-8601, Japan. maruyama@med.nagoya-cu.ac.jp
Aoki
Mikiko
M
Okamura
Sou
S
Yoshida
Ayako
A
Itagaki
Tadashi
T
Ohta
Nobuo
N
D000818:Animals; D002645:Chickens; D005243:Feces / Q000469:parasitology; D007413:Intestinal Mucosa / Q000033:anatomy & histology / Q000469:parasitology*; D007422:Intestines / Q000033:anatomy & histology / Q000469:parasitology; D007814:Larva / Q000254:growth & development; D051379:Mice; D009093:Mucus / Q000469:parasitology / Q000502:physiology; D009348:Nematoda / Q000254:growth & development / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D012377:Rodentia; D013321:Strongyloides / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*