Vitamin E attenuates reserpine-induced oral dyskinesia and striatal oxidized glutathione/reduced glutathione ratio (GSSG/GSH) enhancement in rats.
The effects of a previous and concomitant treatment with vitamin E (VE) were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats treated with reserpine (RE). VE (5, 10, 20 or 40 mg/kg administered intraperitoneally, daily, for 19 days) attenuated the increase in tongue protrusion frequency induced by RE (1 mg/kg administered subcutaneously, on Days 16 and 18, 1 h after VE), which was quantified on Day 19. In a second experiment, a similar treatment with 20 mg/kg VE attenuated RE-induced increase in the striatal ratio of oxidized/reduced glutathione (GSSG/GSH), an index of the oxidative stress process. These results support the free radical hypothesis of tardive dyskinesia.
Abílio
Vanessa C
VC
Departamento de Farmacologia, Universidade Federal de São Paulo, Rua Botucatu, 862-Ed. Leal Prado, São Paulo, SP CEP 04023-970, Brazil.
Araujo
Carlos C S
CC
Bergamo
Marcelo
M
Calvente
Patricia R V
PR
D'Almeida
Vânia
V
Ribeiro
Rosana de A
Rde A
Frussa-Filho
Roberto
R
D018759:Adrenergic Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000737:chemistry; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000662:veterinary; D005978:Glutathione / Q000378:metabolism*; D007279:Injections, Subcutaneous; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000008:administration & dosage / Q000009:adverse effects; D014059:Tongue / Q000502:physiology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D018759:Adrenergic Uptake Inhibitors; D000975:Antioxidants; D014810:Vitamin E; D012110:Reserpine; D005978:Glutathione