Reassessing the presence of Candida albicans in denture-related stomatitis.
OBJECTIVE
The aim of this study was to reevaluate the link between Candida albicans and denture-related stomatitis according to a modified Newton classification, which reflects the classic types of inflammation as well as the extent to which the tissue is affected.


METHODS
Two groups of denture wearers were evaluated for denture-related stomatitis. The presence and number of yeasts on the dentures, the identification of the Candida species present, and the amount of plaque coverage were determined. Putative risk factors were included in the study. Relations between these variables and stomatitis were analyzed statistically.


RESULTS
According to Newton's classification, the presence of yeast on the denture was not linked to whether subjects had stomatitis. But with our classification, higher prevalence of yeast carriers, yeast colony number, and plaque coverage were found on the dentures of individuals with the most extensive inflammation, regardless of Newton type. Among risk factors evaluated, wearing dentures at night and smoking were associated with the most extensive inflammation. We also demonstrated that the presence of C albicans as well as the cohabitation of different Candida species was more frequent in denture-related stomatitis. The differences were statistically significant.


CONCLUSIONS
Statistical analysis of microbiologic data from different denture-related stomatitis categories according to our modified classification showed that the presence of yeast on dentures was significantly associated with the extent of the inflammation, rather than with the Newton type. Our findings suggest that the inflammatory process of stomatitis favors the colonization of Candida. These results could have new implications for diagnosis and management of the condition.
Barbeau
Jean
J
Department of Stomatology, Faculty of Dentistry, Université de Montréal, Québec, Canada. Jean.Barbeau@umontreal.ca
Séguin
Jacynthe
J
Goulet
Jean Paul
JP
de Koninck
Louis
L
Avon
Sylvie Louise
SL
Lalonde
Benoit
B
Rompré
Pierre
P
Deslauriers
Noëlla
N
D000704:Analysis of Variance; D002176:Candida albicans / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000150:complications; D016009:Chi-Square Distribution; D003773:Dental Plaque / Q000382:microbiology; D003827:Denture, Complete, Upper / Q000009:adverse effects / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D016017:Odds Ratio; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013282:Stomatitis, Denture / Q000145:classification / Q000209:etiology / Q000382:microbiology*