[Study on mechanical compression regulating the proliferation of rat mandibular condylar chondrocytes in vitro].
OBJECTIVE
To study the proliferative changes of cultured rat mandibular condylar chondrocytes effected by mechanical compression.


METHODS
Using flow cytometry(FCM) to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes.


RESULTS
During certain force range (0-207 g/cm2), the proliferation of rat mandibular condylar chondrocytes rose, reaching the maximum after 6-hour application of force. The cellular proliferation went down when the chondrocytes were cultured under continuous pressure for 24 hours.


CONCLUSIONS
The proliferation of rat mandibular condylar chondrocytes increase under certain force and certain period of time, but decreased if the applied pressure is beyond the magnitude.
Yang
H
H
College of Stomatology, West China University of Medical Sciences.
Luo
S
S
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D019902:Chondrocytes / Q000502:physiology*; D005434:Flow Cytometry; D008335:Mandibular Condyle / Q000166:cytology*; D051381:Rats; D013314:Stress, Mechanical