Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3.
[reaction: see text] Catalytic Sc(OTf)(3) greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl-aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.
Matteucci
Mizio
M
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton S017 1BJ, United Kingdom.
Bhalay
Gurdip
G
Bradley
Mark
M