Initial in vivo experience of the VentrAssist implantable rotary blood pump in sheep.
VentrAssist (VentrAssist Division, Ventracor Ltd., Chatswood, NSW, Australia) has developed an implantable centrifugal blood pump with an integrated rotor and impeller that is hydrodynamically suspended. Bench testing has been used to assess the performance of the pump under a broad range of operating conditions. This study examined the performance of the pump in vivo up to 90 days implantation. Pumps were implanted via a left lateral thoracotomy. The inflow cannula was inserted at the apex of the left ventricle. The outflow cannula was anastomosed to the descending thoracic aorta. Eighteen implants were performed. Poor recovery from surgery was the main cause of early study termination. These studies demonstrate the suitability of the animal model for evaluation of the VentrAssist rotary blood pump. Further in vivo studies prior to preclinical trials are in progress.
van der Meer
Anita L
AL
VentrAssist Division, Ventracor Ltd., Sydney, New South Wales, Australia.
James
Natalie L
NL
Edwards
Glenn A
GA
Esmore
Donald S
DS
Rosenfeldt
Franklin L
FL
Begg
John D
JD
Woodard
John C
JC
D000818:Animals; D004195:Disease Models, Animal; D006353:Heart-Assist Devices / Q000009:adverse effects*; D011183:Postoperative Complications; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000009:adverse effects*; D020127:Recovery of Function / Q000502:physiology; D012756:Sheep; D015996:Survival Rate; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*