Malignant retroperitoneal paraganglial tumour in a cow.
A large primary retroperitoneal sublumbar neoplasm was identified in an 11-year-old Holstein cow, with metastases to the lungs, kidneys and lymph nodes. The tumour cells proliferated in a characteristic endocrine pattern, were argyrophilic and positive for neuron-specific enolase, and had membrane-bounded intracytoplasmic granules. In addition, the cells were occasionally positive for cytokeratin and had desmosome-like intercellular junctions. The primary tumour mass was diagnosed as a malignant paraganglial tumour of the aortico-sympathetic ganglion (organ of Zuckerkandl), and was considered to contain primitive cells with epithelial differentiation.
Matsuda
K
K
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Mochizuki
T
T
Kobayashi
Y
Y
Furuoka
H
H
Matsui
T
T
Umemura
T
T
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003896:Desmosomes / Q000648:ultrastructure; D005260:Female; D005728:Ganglia, Sympathetic / Q000473:pathology; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000556:secondary / Q000662:veterinary; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D010235:Paraganglioma / Q000737:chemistry / Q000556:secondary / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012186:Retroperitoneal Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D016622:Silver Staining / Q000662:veterinary
D014408:Biomarkers, Tumor; D007633:Keratins; D010751:Phosphopyruvate Hydratase