title: Expression of 1A6 gene and its correlation with intestinal gastric carcinoma.
abstract: OBJECTIVE
  To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.
  
  
  METHODS
  One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.
  
  
  RESULTS
  The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant.
  
  
  CONCLUSIONS
  As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
authors.affiliation: Department of Pathology, Peking University School of Oncology, Beijing 100036, China.
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Tao
authors.initials: T
authors.lastname: Ning
authors.forename: Yang
authors.initials: Y
authors.lastname: Ke
authors.forename: Ji-You
authors.initials: JY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D012016:Reference Values; D012509:Sarcoma / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D014157:Transcription Factors