[Delayed cardioprotection of captopril in patients undergoing open heart surgery].
OBJECTIVE
To investigate whether there is delayed cardioprotection of captopril pretreatment in open heart surgery.


METHODS
Twenty patients with ventricular septal defect (VSD) undergone open heart surgery were randomly divided into captopril group (CAP group) and control group. In the CAP group, patients were pretreated with captopril (1 mg.kg-1, oral) at 48 hours before operation, No special treatment was given at the same time in the control group. Release of creatine phosphokinase-MB (CK-MB) and myocardial adenosine triphosphate (ATP) content was studied. Heart shock protein 70 (HSP70) in myocardum was examined using Western blotting analysis.


RESULTS
No statistically significant difference was found in release of CK-MB between control group and CAP group. ATP depletion was (1.40 +/- 0.56) mumol.g-1, (2.06 +/- 0.72) mumol.g-1 in CAP group and control group respectively (P < 0.05). Western blotting analysis showed that both group had HSP70 expression. In CAP group, HSP70 expression was higher than that in control group.


CONCLUSIONS
The results suggest that captopril pretreatment 48 hours before operation could reduce ATP depletion in pediatric patients of VSD during open-heart surgery, and HSP70 might be involved in the delayed cardioprotection induced by captopril.
Huang
L J
LJ
Department of Cardiothoraci Surgery, Xiangya Hospital, Central South University, Changsha 410008.
Chen
S X
SX
Lou
W J
WJ
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents; D002648:Child; D002675:Child, Preschool; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D008297:Male; D011300:Preoperative Care
D000806:Angiotensin-Converting Enzyme Inhibitors; D002316:Cardiotonic Agents; D018840:HSP70 Heat-Shock Proteins; D002216:Captopril