Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system.
The recent appreciation that two G-protein-coupled receptors, metabotropic glutamate and cannabinoid, are trans-synaptically linked by a small lipid messenger has profound implications, both for control of synaptic transmission and for novel therapeutic strategies. There is much evidence for this assertion and on the significance of this dual receptor cooperation for modulation of synaptic transmission in the central nervous system.
Doherty
James
J
Correspondence: Department of Neuroscience, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19803, USA. james.doherty@astrazeneca.com
Dingledine
Raymond
R
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D018094:Receptors, Metabotropic Glutamate