title: Analysis of skin line pattern for lesion classification.
abstract: OBJECTIVE
  It has been observed that skin patterning tends to be disrupted by malignant but not by benign skin lesions. This suggests that measurements of skin pattern disruption on simply captured white light optical skin images could be a useful contribution to a diagnostic feature set. Previous work using a measurement of line strength by a consistent high-value profiling technique followed by local variance measurement or a region agglomerative classifier to measure skin line pattern disruption was extremely promising but computationally intensive, suggesting that the idea of measuring skin pattern disruption was useful but a simpler method was required.
  
  
  METHODS
  The skin pattern was extracted by high-pass filtration and enhanced by adaptive anisotropic (spatial variant) filtering which smoothes along skin lines but not across them. The skin line main direction and direction variance were estimated using a local image gradient matrix and the difference of these measures across the lesion image boundary was used as a lesion classifier.
  
  
  RESULTS
  A set of images of malignant melanoma and benign naevi were processed as above and the scatter plot of results in a two-dimensional feature (line direction and line variation difference) space showed excellent separation of benign and malignant lesions. An ROC plot enclosed an area of 0.88.
  
  
  CONCLUSIONS
  The experimental results showed that the local line direction and the local line variation were promising features for distinguishing malignant melanoma from benign lesion and the methods used were effective and computationally low-cost.
authors.affiliation: School of Informatics, University of Wales, Dean Street, Bangor, LL57 1UT, UK.
authors.forename: Zhishun
authors.initials: Z
authors.lastname: She
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fish
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008953:Models, Anatomic; D009506:Nevus / Q000473:pathology*; D012372:ROC Curve; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*