[Simultaneous determination of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride in composite tablets by high performance liquid chromatography].
An HPLC method is described for the determination of chlorpheniramine, paracetamol and pseudoephedrine hydrochloride simultaneously in Nuonuo composite tablets. Chromatographic conditions were: column, YWG-C18 column (150 mm x 4.0 mm i.d., 10 microns); mobile phase, 25% methanol(0.05 mol/L sodium dihydrogen phosphate); flow rate, 1.0 mL/min; detection wavelength, 205 nm; injection volume, 20 microL. The detection limits of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride were 1.16 mg/L, 0.15 mg/L and 1.82 mg/L respectively and the corresponding average recoveries were 98.35% (n = 5, RSD = 1.60%), 101.16% (n = 5, RSD = 1.50%) and 98.50% (n = 5, RSD = 1.59%) respectively. The proposed method is simple, rapid and accurate and has been satisfactorily used for the quantitative analysis of real samples.
Chen
Z L
ZL
Department of Chemistry, Fuzhou University, Fuzhou 350002, China.
Zhang
L
L
Wang
M
M
Huang
Y
Y
D000082:Acetaminophen / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry; D002744:Chlorpheniramine / Q000032:analysis*; D004338:Drug Combinations; D004809:Ephedrine / Q000032:analysis*; D013607:Tablets
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D013607:Tablets; D000082:Acetaminophen; D002744:Chlorpheniramine; D004809:Ephedrine