title: Anti-inflammatory and anti-platelet aggregation activity of human placental extract.
abstract: OBJECTIVE
  To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract (HPE, Placentrex).
  
  
  METHODS
  The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin (5-HT), and prostaglandin E1 (PGE1) induced edema in acute model and cotton pellet induced granuloma on sub-acute model. Anti-platelet aggregation was studied against protection of adinosine diphosphate (ADP)-induced aggregation of human platelet through in vitro study.
  
  
  RESULTS
  HPE showed positive results both in acute and sub-acute models of inflammation. Highly significant (P<0.01) results were obtained against 5-HT induced acute inflammation and cotton pellet induced sub-acute inflammation in comparison with standard (diclofenac sodium) and control (normal saline) drugs. The anti-inflammatory property of HPE in animal model was well supported with clinical study of platelet aggregation. There was highly significant (P<0.01) inhibition of platelet aggregation with HPE at different doses against ADP.
  
  
  CONCLUSIONS
  Our data suggest that human placental extract may be useful in suppressing inflammation and platelet aggregation.
authors.affiliation: Department of Pharmacology, Dr BC Roy Postgraduate Institute of Basic Medical Sciences 244B, Acharya J C Bose Road, Calcutta 700020, India.
authors.forename: Tapas Kumar
authors.initials: TK
authors.lastname: Sur
authors.forename: Tuhin Kanti
authors.initials: TK
authors.lastname: Biswas
authors.forename: Liaquat
authors.initials: L
authors.lastname: Ali
authors.forename: Biswapati
authors.initials: B
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D010924:Placental Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008419:Materia Medica; D010924:Placental Extracts; D010975:Platelet Aggregation Inhibitors