title: Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21.
abstract: Human personality traits are moderately heritable but only recently have specific polymorphisms been associated with particular personality dimensions especially anxiety-related and novelty-seeking traits. The first genome-wide scan for personality traits was recently carried out by Cloninger et al. [1998: Am J Med Genet 81:313-317] and his colleagues and they reported that a region on 8p21 showed linkage to TPQ Harm Avoidance, an anxiety-related personality trait. Towards replicating and extending these results, we examined both 8p21 and two additional chromosomal regions (1q21-24 and 22q12-13) for linkage to TPQ personality traits by genotyping at least three microsatellite markers in each region in a group of 384 sibling pairs. We found evidence for linkage to TPQ HA at 8p21-23 (Lod score = 2.907) confirming in an independent sample the initial findings by Cloninger and his colleagues.
authors.affiliation: The Ruppin Institute of Higher Education, Emek Hefer 40250, Israel.
authors.forename: Ada H
authors.initials: AH
authors.lastname: Zohar
authors.forename: Christian
authors.initials: C
authors.lastname: Dina
authors.forename: Naama
authors.initials: N
authors.lastname: Rosolio
authors.forename: Yamima
authors.initials: Y
authors.lastname: Osher
authors.forename: Inga
authors.initials: I
authors.lastname: Gritsenko
authors.forename: Rachel
authors.initials: R
authors.lastname: Bachner-Melman
authors.forename: Jonathan
authors.initials: J
authors.lastname: Benjamin
authors.forename: Robert H
authors.initials: RH
authors.lastname: Belmaker
authors.forename: Richard P
authors.initials: RP
authors.lastname: Ebstein
mesh_terms: D001008:Anxiety Disorders / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010551:Personality / Q000235:genetics*; D035781:Siblings; D011795:Surveys and Questionnaires