title: Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Feling
authors.forename: Greg O
authors.initials: GO
authors.lastname: Buchanan
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: Mincer
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification; D000230:Adenocarcinoma / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism; D018360:Crystallography, X-Ray; D003546:Cysteine Endopeptidases; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex; D011758:Pyrroles; D014407:Tumor Cells, Cultured
chemical_list: D007783:Lactones; D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D011758:Pyrroles; C475865:marizomib; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex