title: [Animal experimental study on endocrine factors affecting alveolar repair].
abstract: OBJECTIVE
  To investigate the endocrine effects on activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) and to obtain the mechanism of the resorption and regeneration of the alveolar bone.
  
  
  METHODS
  24 dog models with two-side osseous infrabony pocket were divided into 4 groups randomly and were studied by histologic examination, enzyme cytochemistry and image analysis system.
  
  
  RESULTS
  The activities of ALP and ACP, except ACP in the sixth month significantly decreased in the group of thyroidism comparing with that of the control group (P < 0.01), but only the activities of ALP significantly decreased in groups of ovariectomy and diabetes (P < 0.05, P < 0.01), and there was close relationship between enzyme activities and histopathologic variations.
  
  
  CONCLUSIONS
  Alveolar bone repair was regulated by systemic endocrine factors and was associated with the activities of ALP and ACP osteoblasts of and osteoclasts.
authors.affiliation: Ninth Affiliated Renmin Hospital, Shanghai Second Medical University.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Ye
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000539:Alveolar Process / Q000201:enzymology*; D000818:Animals; D001862:Bone Resorption / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004285:Dogs; D005260:Female; D008297:Male; D010052:Ovariectomy; D013974:Thyroxine / Q000378:metabolism*
chemical_list: D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D013974:Thyroxine