title: Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness.
abstract: Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA. rhenders@lrri.org
authors.forename: R F
authors.initials: RF
authors.lastname: Henderson
authors.forename: E B
authors.initials: EB
authors.lastname: Barr
authors.forename: W B
authors.initials: WB
authors.lastname: Blackwell
authors.forename: C R
authors.initials: CR
authors.lastname: Clark
authors.forename: C A
authors.initials: CA
authors.lastname: Conn
authors.forename: R
authors.initials: R
authors.lastname: Kalra
authors.forename: T H
authors.initials: TH
authors.lastname: March
authors.forename: M L
authors.initials: ML
authors.lastname: Sopori
authors.forename: Y
authors.initials: Y
authors.lastname: Tesfaigzi
authors.forename: M G
authors.initials: MG
authors.lastname: Ménache
authors.forename: D C
authors.initials: DC
authors.lastname: Mash
authors.forename: K
authors.initials: K
authors.lastname: Dokladny
authors.forename: W
authors.initials: W
authors.lastname: Kozak
authors.forename: A
authors.initials: A
authors.lastname: Kozak
authors.forename: M
authors.initials: M
authors.lastname: Wachulec
authors.forename: K
authors.initials: K
authors.lastname: Rudolph
authors.forename: M J
authors.initials: MJ
authors.lastname: Kluger
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Razani-Boroujerdi
authors.forename: R J
authors.initials: RJ
authors.lastname: Langley
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002619:Chemical Warfare Agents / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology*; D004195:Disease Models, Animal; D007107:Immune System / Q000187:drug effects; D019570:Inhalation Exposure; D008569:Memory Disorders / Q000209:etiology*; D018923:Persian Gulf Syndrome; D051381:Rats; D011916:Rats, Inbred F344; D011950:Receptors, Cholinergic / Q000032:analysis* / Q000187:drug effects; D012524:Sarin / Q000009:adverse effects*
chemical_list: D002619:Chemical Warfare Agents; D011950:Receptors, Cholinergic; D012524:Sarin