[Effects of biomaterials on immunoglobulins and biochemistry in serum of extracoporal circulation].
The polyvinyl chloride(PVC) tube coated with cellulose acetate(CA), polyether suffone(PES), polyurethane(PU), silicon rubber(SR) and polyester fibre(PETF) were put in contact with circular serum at 37 degrees C. According to different time-periods of exposure, the immunoglobulins (G.A.M), albumin(ALB), total protein (TP) and total cholesteral(Tch) in serum were measured by an IL-Monarch biomedical analyser. The results showed that the levels of immunoglobutins significantly decreased after the serum came in contact with CA, PETF, SR and that the levels of ALB, TP and Tch were significantly lower in the serum exposed to PETF while those in the serum exposed to other materials were normal. These changes may relate to the complement activation induced by different materials.
Zhu
M
M
Biomaterial Test Center of Sichuan, Chengdu 610041.
Wu
Z
Z
Zheng
Y
Y
Huang
P
P
Shun
T
T
Jiang
L
L
Yei
C
C
Li
N
N
D001672:Biocompatible Materials / Q000633:toxicity*; D001798:Blood Proteins / Q000187:drug effects* / Q000378:metabolism; D002482:Cellulose / Q000633:toxicity; D005112:Extracorporeal Circulation; D006801:Humans; D007136:Immunoglobulins / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008422:Materials Testing; D011140:Polyurethanes / Q000633:toxicity; D011143:Polyvinyl Chloride / Q000633:toxicity; D012709:Serum Albumin / Q000187:drug effects* / Q000378:metabolism
D001672:Biocompatible Materials; D001798:Blood Proteins; D007136:Immunoglobulins; D011140:Polyurethanes; D012709:Serum Albumin; D011143:Polyvinyl Chloride; D002482:Cellulose