title: Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region.
abstract: The sequence-based map of a part of the rhesus macaque major histocompatibility complex (MHC) extended class II region is presented. The sequenced region encompasses 67,401 bp and contains the SACM2L, RING1, FABGL and KE4 genes, as well as the HTATSF1-like and ZNF-like pseudogenes. Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L- RING1 interval. The rhesus macaque extended MHC class II region shows a high degree of conservation of exonic as well as intronic and intergenic sequences compared with the respective human region. It is concluded that this particular genomic organization of the extended class II region-i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes-can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago.
authors.affiliation: Max-Planck-Institut für Molekulare Genetik, Berlin, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Sudbrak
authors.forename: Richard
authors.initials: R
authors.lastname: Reinhardt
authors.forename: Steffen
authors.initials: S
authors.lastname: Hennig
authors.forename: Hans
authors.initials: H
authors.lastname: Lehrach
authors.forename: Eberhard
authors.initials: E
authors.lastname: Günther
authors.forename: Lutz
authors.initials: L
authors.lastname: Walter
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data