title: Expression of tissue factor is associated with clinical features and angiogenesis in prostate cancer.
abstract: BACKGROUND
  Tissue factor (TF), the main initiator of blood coagulation, is involved in cancer metastasis and progression. We examined the role of TF on prostate cancer.
  
  
  METHODS
  Immunohistochemical analysis was performed using the anti-TF antibody. Intra-tumoral blood vessels were visualized by staining endothelial cells with CD34 antibody. We examined the expression of TF and the microvessel density (MVD) in 66 biopsy specimens of prostate cancer, in order to investigate the relationship between the expression of TF and the clinicopathology of prostate cancer.
  
  
  RESULTS
  TF antigen was positive in 41 (62%) of the specimens. There were significant differences in TF expression according to the pretreatment prostate specific antigen (PSA) level (p = 0.0193) and bone metastasis (p = 0.0029). MVD was significantly related to bone metastasis (p = 0.0175). TF-positive carcinomas more frequently presented high MVD expressions (p = 0.017) than TF-negative tumors.
  
  
  CONCLUSIONS
  These results suggest that increased angiogenesis associated with TF expression might cause the metastasis and progression of prostate cancer.
authors.affiliation: Department of Urology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan. a0412@ms.toyama-mpu.ac.jp
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohta
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakazaki
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maeda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
authors.forename: Shin
authors.initials: S
authors.lastname: Nakamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagakawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Furuya
authors.forename: Hideki
authors.initials: H
authors.lastname: Fuse
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D013925:Thromboplastin / Q000096:biosynthesis*
chemical_list: D013925:Thromboplastin