[Expression of bone morphogenetic protein (BMP)-2, 4 in mouse embryonic tooth during the bud stage].
OBJECTIVE
The purpose of this paper was to investigate the distributions of bone morphogenic protein (BMP)-2, 4 in the developing molars of mice during the bud stage and, the functional relationship between BMP-2 and BMP-4.


METHODS
The distribution of BMP-2, 4 were examined in developing mouse molars on the 14th (the 14th embryonic day), using monoclonal antibodies and immunohistochemistry methods.


RESULTS
BMP-2, 4 were detected both in the epithelial cells and dental mesenchyme cells.


CONCLUSIONS
There is a similar distribution pattern between BMP-2 and BMP-4. Therefore, there may be a functional relationship between BMP-2 and BMP-4 during the development of mouse embryonic teeth in the bud stage.
Zhang
J
J
College of Stomatology, West China University of Medical Sciences.
Tian
W
W
Liu
L
L
Li
S
S
Tang
W
W
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis*; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014070:Tooth / Q000196:embryology / Q000378:metabolism*; D014083:Tooth Germ / Q000196:embryology / Q000378:metabolism*; D016212:Transforming Growth Factor beta
C525719:Bmp2 protein, mouse; C525720:Bmp2 protein, rat; C525810:Bmp4 protein, mouse; C525811:Bmp4 protein, rat; D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta