[Bcl-2 protein expression in developing human brain].
Using immunocytochemical methods, the expression of bcl-2 antiapoptotic protein was studied in developing brain of human 5-8-week embryos. It was established that during the period studied several zones of bcl-2-positive cell concentration were present. These included the ventricular zone of the brain vesicles wall, cortical plate, medullary nuclei, vascular plexus primordium (in 5-6-week embryos), IV ventricle roof and vascular plexus of rhombencephalon. In the area of forming leptomeninx, bcl-2 protein was demonstrated in the endothelium of blood vessels. The detection of intensified expression of bcl-2 protein in some cellular populations of developing human brain proves their increased stability against apoptosis and indicates their priority significance in the provision of normal neurohistogenesis.
Korzhevskiĭ
D E
DE
Department of Morphology, RAMS Scientific Research Institute of Experimental Medicine and Laboratory of Normal and Pathological Physiology of the Fetus, D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology, St. Petersburg.
Talantova
O E
OE
Pavlova
N G
NG
D001921:Brain / Q000196:embryology* / Q000378:metabolism*; D002831:Choroid Plexus / Q000196:embryology / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D019579:Neocortex / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism
D019253:Proto-Oncogene Proteins c-bcl-2