[Influence of human cytomegalovirus infection on the expression of HOXB5, HOXB6, HOXB7, and HOXB8 genes in gliomaous cells].
The expressions of HOXB5, HOXB6, HOXB7, and HOXB8 genes of U251 cell infected by human cytomegalovirus and/or treated with all trans-retinoic acid(ATRA) were detected by semi-quantitative RT-PCR. The results were that U251 cell did not express HOXB5, HOXB6, and HOXB8 but expressed HOXB7 without infecting HCMV and/or being treated with ATRA. After infected with HCMV and/or treated with ATRA, the expressions of HOXB7 and HOXB8 were up-regulated and the expression of HOXB7 lasted the fourth generation, while HOXB8 was up-regulated only in the second generation. These results indicate that the abnormal expression of HOXB gene induced by HCMV may play an important role in the maldevelopment.
Wu
G J
GJ
Department of Microbiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Chen
L Y
LY
Dai
G
G
D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000235:genetics / Q000378:metabolism*; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
C489126:HOXB5 protein, human; C093252:HOXB6 protein, human; C490538:HOXB7 protein, human; C490669:HOXB8 protein, human; D018398:Homeodomain Proteins; C490537:Hoxb6 protein, mouse