Endoneurial microangiopathy of sural nerve in experimental vacor-induced diabetes.
The pathogenic mechanism of diabetic peripheral neuropathy is multifactorial. This study investigated microangiopathic changes of endoneurial vessels of sural nerve in Vacor-induced diabetic rats. Experimental rats were divided into 3 groups: acute (80 mg/kg, once), chronic diabetic (8 mg/kg, 14 times), and control. Ultrastructural morphometric parameters of endoneurial microvessels, blood glucose, and body weight changes were statistically analyzed, and correlations among the variables were evaluated. The body weight and blood glucose levels were significantly different between the control and diabetic rats. The blood glucose was more significantly elevated in the acute diabetic rats than the chronic diabetic rats. Inner and outer vascular circumference, vascular area, luminal area, basement membrane area, and basement membrane thickness were significantly increased in the acute diabetic rats compared to the control group, but not between the chronic diabetic rats and the control group. The thickness of basement membrane was positively correlated with hyperglycemia and body weight loss (P < .01). These results suggest that the microangiopathy of the peripheral nerve could be developed in acute Vacor-induced diabetes. The decreased perfusion through microangiopathic endoneurial vessels appears to have a pathogenic role causing diabetic peripheral neuropathy.
Kim
Jung-Min
JM
Department of Medicine, Chonnam National University Medical School and Research Institute of Medical Sciences, Kwangju, Korea.
Lee
Tai-Hee
TH
Lee
Min-Cheol
MC
Moon
Jae-Dong
JD
Lee
Ji-Shin
JS
Kim
Hyung-Seok
HS
Suh
Chae-Hong
CH
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000473:pathology; D003925:Diabetic Angiopathies / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D006943:Hyperglycemia / Q000139:chemically induced / Q000473:pathology; D008297:Male; D010671:Phenylurea Compounds; D051381:Rats; D017208:Rats, Wistar; D013497:Sural Nerve / Q000098:blood supply* / Q000648:ultrastructure; D015431:Weight Loss
D010671:Phenylurea Compounds; C012598:pyriminil