title: RNA as a drug target.
abstract: In the antiviral and antibacterial area, increasing drug resistance means that there is an ever growing need for novel approaches towards structures and mechanisms which avoid the current problems. The huge increase in high resolution structural data is set to make a dramatic impact on targeting RNA as a drug target. The examples of the RNA binding antibiotics, particularly, the totally synthetic oxazolidinones, should help persuade the skceptics that clinically useful, selective drugs can be obtained from targeting RNA directly.
authors.affiliation: Department of Chemistry, RiboTargets Ltd., Granta Park, Abington, Cambridge, CB1 6GB, UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Drysdale
authors.forename: Georg
authors.initials: G
authors.lastname: Lentzen
authors.forename: Natalia
authors.initials: N
authors.lastname: Matassova
authors.forename: Alastair I H
authors.initials: AI
authors.lastname: Murchie
authors.forename: Fareed
authors.initials: F
authors.lastname: Aboul-Ela
authors.forename: Mohammad
authors.initials: M
authors.lastname: Afshar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D009690:Nucleic Acid Conformation; D011500:Protein Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000187:drug effects; D012335:RNA, Ribosomal / Q000187:drug effects*; D012367:RNA, Viral / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D011500:Protein Synthesis Inhibitors; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D012367:RNA, Viral