title: [Study on the association between HPV16/18 and expression of p53 protein in laryngeal papillomas].
abstract: OBJECTIVE
  To understand the relationship between the expression of p53 protein and HPV16/18 infection in laryngeal papillomas.
  
  
  METHODS
  Using PCR and immunohistochemistry techniques examined the paraffin embedded tissues of 35 cases of laryngeal papillomas.
  
  
  RESULTS
  Showed that HPV16/18-DNA were found in 24 cases of laryngeal papillomas (68.8%); overexpression of p53 protein were detected in 19 cases (54.3%); both of HPV16/18-DNA and overexpression of p53 protein were demonstrated in 12 cases of laryngeal papillomas (34.3%).
  
  
  CONCLUSIONS
  This study suggests that HPV16/18 infection and p53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and p53 mutation in tissues of laryngeal papillomas remains to be clarified.
authors.affiliation: Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Chu
authors.forename: E
authors.initials: E
authors.lastname: Reyt
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000821:virology*; D008297:Male; D010212:Papilloma / Q000378:metabolism / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D004279:DNA, Viral; D016159:Tumor Suppressor Protein p53