A new connection: chaperones meet a mitochondrial receptor.
Cytosolic chaperones stabilize cellular proteins under stress conditions and protect nascent protein chains during normal growth. Recent data from Young et al. (2003) extend the function of chaperones by demonstrating that Hsp90 and Hsp70 specifically interact with the mitochondrial protein import receptor Tom70 at the outer membrane and are required for translocation of precursor proteins.
Voos
Wolfgang
W
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.
D005656:Fungal Proteins / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism
D005656:Fungal Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D011498:Protein Precursors; D011956:Receptors, Cell Surface