title: [Bcl-2 and bax expression in rat cerebral ischemic preconditioning].
abstract: OBJECTIVE
  To study the expression of apoptosis regulated genes bcl-2 and bax nocoprotein expression and its significance in rat cerebral ischemic preconditioning.
  
  
  METHODS
  With immunohistochemical assay, bcl-2 and bax expression were studied in rat brains which were divided into four groups: the sham-operation control group, the cerebral ischemic group and the cerebral ischemic preconditioning group.
  
  
  RESULTS
  Bcl-2 oncoprotein was induced in cerebral ischemic preconditioning control group. Bax oncoprotein expression had no obviously difference in four groups.
  
  
  CONCLUSIONS
  The expression of bcl-2 and bax oncoprotein after sublethal ischemic preconditioning might be associated with the preconditioning protection against neuronal damage following subsequent lethal ischemia.
authors.affiliation: Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: E
authors.initials: E
authors.lastname: Wang
authors.forename: Q L
authors.initials: QL
authors.lastname: Guo
authors.forename: X J
authors.initials: XJ
authors.lastname: Tan
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000235:genetics / Q000378:metabolism*; D019194:Ischemic Preconditioning; D008297:Male; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein
chemical_list: C494828:Bax protein, rat; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein