title: [The immunologic study on local nasal immunotherapy for perennial allergic rhinitis].
abstract: OBJECTIVE
  To investigate the clinical efficacy and immune mechanism of local nasal immunotherapy (LNIT).
  
  
  METHODS
  142 cases of perennial allergic rhinitis (PAR) were treated with LNIT. Immunologic study was carried out in 30 cases.
  
  
  RESULTS
  LNIT was as effective as traditional subcutaneous immunotherapy (P > 0.05). Immunologic study demonstrated, that the nasal secretory IgA (S-IgA) increased significantly after treatment (P < 0.05). The levels of nasal secretory total IgE, serum total IgE and serum specific IgE (anti-mite, ragweed pollon) decreased, but there was no significance (P > 0.05).
  
  
  CONCLUSIONS
  LNIT can improve the local immune function and modify the local nasal allergic inflammatory response. It is an effective, safe and convenient treatment.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029.
authors.forename: Q H
authors.initials: QH
authors.lastname: Qi
authors.forename: Z C
authors.initials: ZC
authors.lastname: Pu
authors.forename: M D
authors.initials: MD
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000628:therapy*
chemical_list: D007071:Immunoglobulin A, Secretory; D007073:Immunoglobulin E