[Protective effect of berberine on isolated perfused heart in heart failure].
OBJECTIVE
To examine the protective action of berberine against the development of heart failure.


METHODS
Wister rats were divided into two groups. The Langendorff perfusion of isolated heart was performed and Verapamil was used to bring about acute heart failure. The experiment group was given berberine (10(-6) mol/L) before the use of Verapamil, but the control group was not given the berberine. A comparison was made on the degree of heart failure between the two group.


RESULTS
The degree of heart failure in the experiment group was significantly less severe than that in the control group (P < 0.001).


CONCLUSIONS
Berberine has the protective action against to the development of heart failure.
Zhou
Z
Z
Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
Xu
J
J
Lan
T
T
D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002303:Cardiac Output, Low / Q000139:chemically induced / Q000517:prevention & control; D066298:In Vitro Techniques; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil
D002120:Calcium Channel Agonists; D020011:Protective Agents; D001599:Berberine; D014700:Verapamil