title: [A study on lyophilization injection of cucurbitacin polylactic acid nanoparticles].
abstract: OBJECTIVE
  To prepare stable and redispersable Lyophilization injection of cucurbitacin polylactic acid nanoparticles(Cu-PLA-NP).
  
  
  METHODS
  An optimal supporting agent was chosen to prepare the Cu-PLA-NP lyophilization injection. The physical and chemical properties of the injection were evaluated.
  
  
  RESULTS
  The shape, diameters, association ratio, drug loading and pH of Cu-PLA-NP colloidal solution and lyophilization injection were not changed. The content of water consisted with the requirement of lyophilization injection. The critical relative humidity was 69.52%. The stability was good.
  
  
  CONCLUSIONS
  It is practicable to prepare Cu-PLA-NP lyophilization injection with proper formulas and preparation processes.
authors.affiliation: School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, Sichuan, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: S X
authors.initials: SX
authors.lastname: Hou
mesh_terms: D054728:Cucurbitacins; D004337:Drug Carriers; D004355:Drug Stability; D005612:Freeze Drying; D007267:Injections; D019344:Lactic Acid; D011091:Polyesters; D011108:Polymers; D013678:Technology, Pharmaceutical; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D014315:Triterpenes; D019344:Lactic Acid; C033616:poly(lactide); D054728:Cucurbitacins