title: Giant multilocular cystadenoma of the prostate responsive to GnRH antagonists.
abstract: Giant multilocular cystadenoma of the prostate is a rare, benign, but locally recurrent, tumor that is usually treated by surgery. We report a case initially treated by surgical resection and followed by evaluation of serum prostate-specific antigen values. After evidence of biochemical failure, pathologic recurrence was confirmed and treated by the gonadotropin-releasing hormone antagonist Lupron, with excellent results. The patient was stable without biochemical or radiologic evidence of progression during the last 2.5 years. This result offers a new treatment option for patients with this rare tumor.
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
authors.forename: Milton W
authors.initials: MW
authors.lastname: Datta
authors.forename: Janet
authors.initials: J
authors.lastname: Hosenpud
authors.forename: Vladimir
authors.initials: V
authors.lastname: Osipov
authors.forename: Robert H
authors.initials: RH
authors.lastname: Young
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003537:Cystadenoma / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000188:drug therapy*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017430:Prostate-Specific Antigen; D016729:Leuprolide