Handling of computational in vitro/in vivo correlation problems by Microsoft Excel II. Distribution functions and moments.
MS Excel is a useful tool to handle in vitro/in vivo correlation (IVIVC) distribution functions, with emphasis on the Weibull and the biexponential distribution, which are most useful for the presentation of cumulative profiles, e.g. release in vitro or urinary excretion in vivo, and differential profiles such as the plasma response in vivo. The discussion includes moments (AUC and mean) as summarizing statistics, and data-fitting algorithms for parameter estimation.
Langenbucher
Frieder
F
BioVista LLC, Riehen, Switzerland. mysickaj@ivivc.com
D000465:Algorithms; D000704:Analysis of Variance; D019540:Area Under Curve; D006801:Humans; D066298:In Vitro Techniques; D008432:Mathematical Computing; D004364:Pharmaceutical Preparations; D010599:Pharmacokinetics; D012984:Software / Q000706:statistics & numerical data; D013997:Time Factors
D004364:Pharmaceutical Preparations