title: [Candida infection in hip alloarthroplasty].
abstract: A 46-year-old polytoxicomanic patient underwent a total hip replacement for necrosis of the femoral head. The patient suffered additionally from chronic pancreatitis with insulin-dependent diabetes and polyneuropathy. Three weeks later he developed a deep wound infection followed by surgical revision. The infection persisted despite further revision operations and systemically and locally applied antibiotics. After removal of the prosthesis,microbiology revealed Staphylococcus aureus, enterococcus,and Candida parapsilosis. Five additional revision operations, application of suction-irrigation drainage, and systemically administered antibiotics could not stop the infectious process. The patient was transferred to our institution 3 months after primary surgery. The joint defect was filled with a PMMA Palacos spacer. This time biopsies were only positive for Candida albicans. After 12 days of antifungal therapy with fluconazole,microbiological biopsies were sterile. The spacer was removed and femoral extension applied. After 4 weeks of further antifungal therapy, a revision prosthesis was implanted. Until now no signs of infection have appeared.
authors.affiliation: Klinik für Unfall-, Hand- und Wiederherstellungschirurgie,Klinikum der Universität zu Köln, Cologne.
authors.forename: K L
authors.initials: KL
authors.lastname: Prenzel
authors.forename: J
authors.initials: J
authors.lastname: Isenberg
authors.forename: H J
authors.initials: HJ
authors.lastname: Helling
authors.forename: K E
authors.initials: KE
authors.lastname: Rehm
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy; D005271:Femur Head Necrosis / Q000601:surgery; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy; D012086:Reoperation; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole