title: Electron microscopy of functional ribosome complexes.
abstract: Cryoelectron microscopy has made a number of significant contributions to our understanding of the translation process. The method of single-particle reconstruction is particularly well suited for the study of the dynamics of ribosome-ligand interactions. This review follows the events of the functional cycle and discusses the findings in the context provided by the recently published x-ray structures.
authors.affiliation: Howard Hughes Medical Institute, Health Research, Inc, at the Wadsworth Center, and Department of Biomedical Sciences, State University of New York at Albany, Empire State Plaza, Albany, NY 12201-0509, USA. joachim@wadsworth.org
authors.forename: Joachim
authors.initials: J
authors.lastname: Frank
mesh_terms: D001665:Binding Sites; D020285:Cryoelectron Microscopy; D007091:Image Processing, Computer-Assisted; D012336:RNA, Ribosomal, 16S / Q000648:ultrastructure; D012343:RNA, Transfer / Q000648:ultrastructure; D012358:RNA, Transfer, Met / Q000648:ultrastructure*; D012270:Ribosomes / Q000648:ultrastructure*
chemical_list: D012336:RNA, Ribosomal, 16S; D012358:RNA, Transfer, Met; C089238:fMet-tRNA(fMet); D012343:RNA, Transfer