[Expression of EGFR in keratosis of laryngeal and the correlation with malignant phenotype].
OBJECTIVE
To evaluate the roles of EGFR expression in laryngeal keratosis.


METHODS
The ABC immunohistochemical method was performed to investigate the expression of EGFR in 32 cases of laryngeal keratosis tissue.


RESULTS
The EGFR indices in light, moderate and serious non-typical hyperplasia were 12.5%, 22.5% and 47.8% respectively. There were significant differences between heavy with light and middle non-typical hyperplasia (P < 0.05).


CONCLUSIONS
The EGFR might play some role in the process of carcinogenesis of laryngeal keratosis, and be as an useful marker for the assessment of the behavior and prognosis in the laryngeal premalignant lesions keratosis.
Wang
J
J
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Beijing 100730.
Yang
Q W
QW
Wang
Z P
ZP
D000328:Adult; D000368:Aged; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000378:metabolism* / Q000473:pathology; D007818:Laryngeal Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis
D066246:ErbB Receptors