[Level of chromosome aberrations in peripheral blood lymphocytes in evacuees from the 30-kilometer zone of the Chernobyl Atomic Energy Station and residents of radioactively-polluted territories in the long term after the Chernobyl accident].
Eighteen Ukrainian evacuees from the Chernobyl exclusive zone, twenty one inhabitants of radioactively contaminated areas of Belarus and twelve control donors age-matched to the exposed persons were investigated 14-15 years after the Chernobyl accident for chromosomal aberration yields detected in blood lymphocytes by fluorescence in situ hybridisation technique. Unstable aberration yields measured in both Chernobyl cohorts were close to the background frequencies. Positive age-dependence trends in control donors were determined for the all type stable aberration levels. In evacuees the tendency for diminishing the difference between them and controls for stable aberration levels with persons' age increasing was found. The total stable chromosome exchange yields in evacuees 46-55 years old and inhabitants of areas with low contamination level didn't exceed the control values, but for younger evacuees and inhabitants of sufficiently contaminated regions the statistical increase above the age relevant background meanings was detected for this end-point. The advantages of using the FISH-detectable stable aberrations and particularly the total level of stable chromosome exchanges as the end-points for retrospective biological indication of past radiation exposure in Chernobyl cohorts were discussed.
Maznik
N A
NA
Institute of Medical Radiology Named by S.P. Grigoriev, Academy of Medical Science of Ukraine, Kharkiv, 61024 Ukraine.
Vinnikov
V A
VA
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D011210:Power Plants; D018788:Radioactive Hazard Release; D011848:Radioactive Pollutants / Q000009:adverse effects*; D014455:Ukraine
D011848:Radioactive Pollutants