[Clinical and cytogenetic investigation of a family with high predisposition for intestinal polyps].
A medico-genetic investigation of a family, consisting of 25 members, revealed high predisposition to malignant pathology of the gastrointestinal tract: rectal cancer was diagnosed in 2, malignant polyposis of the large intestine--1, diffuse polyposis of the large intestine (DPLI)--3, and uterine fibromyoma--in 1 patient. Six members underwent a cytogenetic examination using the metaphase method for peripheral blood lymphocytes and G-banding of chromosomes. Two patients with DPLI carried 8.7 and 16.7% of hyperaneuploid cells and one--20% of cells with double minute chromosomes (DMS). It is suggested that formation and subsequent significant increase in hyperaneuploid and DMS cells could have been responsible for DPLI development in the family.
Monakhov
A S
AS
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Guliaev
A V
AV
Aksenov
A V
AV
Khanson
K P
KP
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D003111:Colonic Polyps / Q000235:genetics; D003582:Cytogenetics; D005260:Female; D005350:Fibroma / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics*; D008214:Lymphocytes; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D011003:Ploidies; D014594:Uterine Neoplasms / Q000235:genetics