Successful radioiodine treatment in a 3 year old child with Graves' disease following antithyroid medication induced neutropenia.
A 3 year old child with Graves' disease and mitral valve prolapse became neutropenic on carbimazole therapy. She was switched to propylthiouracil but the neutropenia recurred. She was treated with radioiodine but required two doses of 113 MBq and then 198 MBq five months later before becoming hypothyroid. The mitral valve prolapse resolved when she was euthyroid on thyroxine replacement. Antithyroid drugs, surgery, and radioiodine all have a place in the management of the thyrotoxic child.
Rahman
M A S
MA
Department of Paediatrics, Harrogate District Hospital, Yorkshire HG2 7SX, UK.
Birrell
G
G
Stewart
H
H
Lucraft
H
H
Cheetham
T D
TD
D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008945:Mitral Valve Prolapse / Q000150:complications; D009503:Neutropenia / Q000139:chemically induced*; D011441:Propylthiouracil / Q000009:adverse effects; D013971:Thyrotoxicosis / Q000188:drug therapy
D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D011441:Propylthiouracil; D002231:Carbimazole