Silicon and iron levels in tissues of animals treated with a "ferrimagnetic ceramic" with oncotherapeutic potential (anti-tumor) value.
The stability in a biological environment of an injectable cement with oncotherapeutic potential--consisting of a glass powder of SiO2 (35.6%), CaO (42.4%), P2O5 (17%), Na2O (5%) and 30% of its weight of Fe3O4 dissolved in (NH4)2HPO4 plus NH4H2PO4--was evaluated referring to the release of silicon and iron. The experimental model was the rat, and organs (liver, kidney, spleen, lung, heart, and brain) of the implanted and control animals were collected for quantification of these elements by electrothermal atomization atomic absorption spectrometry methods. In most of the analysed organs no significant difference in the contents of silicon and iron between the implanted and the control animals was found.
Almeida
Teresa
T
INEB/FEUP.
Soares
Maria Elisa
ME
Cavalheiro
José
J
de Lourdes Bastos
Maria
M
D000818:Animals; D001672:Biocompatible Materials; D002516:Ceramics; D006358:Hot Temperature; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008280:Magnetics; D008422:Materials Testing; D009369:Neoplasms / Q000628:therapy*; D019736:Prostheses and Implants; D051381:Rats; D015203:Reproducibility of Results; D012825:Silicon / Q000378:metabolism*; D014020:Tissue Extracts / Q000737:chemistry
D001672:Biocompatible Materials; D014020:Tissue Extracts; D007501:Iron; D012825:Silicon