[Laryngeal function preservation in comprehensive therapy of carcinoma of pyriform sinus].
OBJECTIVE
To investigate the sufficiency of comprehensive therapy in the preservation of laryngeal function of carcinoma of pyriform sinus.


METHODS
Since 1986, 33 cases of pyriform sinus carcinoma were treated, the clinical stages were as follows: stage I 2 cases, stage II 9 cases, stage III 12, stage IV 10. The induced chemotherapy agents were cisplatin, methotrexate and pingyangmycin. Surgical treatment include local dissection of tumor, partial hypopharynx and partial larynx dissection. All patients were received postoperative radiotherapy.


RESULTS
Chemotherapy partial response rate was 42.4%, 3 years survive rate was 54.8%, 5 years survive rate was 38.7%.


CONCLUSIONS
The cisplatin centered combined induced chemotherapy was effective in the treatment of pyriform sinus, the laryngeal function preservation surgical treatment of pyriform sinus carcinoma in T1 T2 and selective T3 patients is practicable. Postoperative radiotherapy can improve the local control rate.
Fang
J G
JG
Department of Head and Neck Surgery, Shandong Tumor Hospital and Institute, Jinan 250117.
Liang
E H
EH
Luan
X Y
XY
Wang
T D
TD
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000628:therapy*; D007830:Larynx / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate