title: Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm.
abstract: Posterior leukoencephalopathy syndromes have been reported with hypertension, and immunosuppressive and chemotherapy agents. Cerebral vasospasm on MR angiography (MRA) has been noted in cases due to eclampsia. The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine. Hypertension was not present. Diffuse, reversible arterial irregularities consistent with vasospasm were present on MRA during the acute illness.
authors.affiliation: Department of Neurology, Royal Brisbane Hospital, Herston, Australia. Robert_Henderson@health.qld.gov.au
authors.forename: R D
authors.initials: RD
authors.lastname: Henderson
authors.forename: T
authors.initials: T
authors.lastname: Rajah
authors.forename: A J
authors.initials: AJ
authors.lastname: Nicol
authors.forename: S J
authors.initials: SJ
authors.lastname: Read
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001766:Blindness / Q000209:etiology; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000209:etiology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D018450:Disease Progression; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D020127:Recovery of Function; D013577:Syndrome; D013610:Tachycardia / Q000150:complications / Q000175:diagnosis; D020301:Vasospasm, Intracranial / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D003561:Cytarabine; D008727:Methotrexate