[Cerebral uptake and regional distribution of [11C]-vinpocetin after intravenous administration to healthy men: a PET study].
BACKGROUND
Vinpocetine is a compound widely used in the prevention and treatment of cerebrovascular diseases. The exact mechanism of action of the drug is still not known. The objective of the present investigation was to determine the global uptake and regional distribution of radiolabelled vinpocetine in the human brain. Three healthy persons were examined with positron emission tomography (PET) and [11C]-vinpocetine.


RESULTS
The uptake of [11C]-vinpocetine in brain was rapid and on average as a maximum 3.7% of the total radioactivity injected was in the brain 2 minutes after radioligand administration. The uptake was heterogeneously distributed among brain regions. When compared with the cerebellum, an a priori reference region, the highest regional uptake was in the thalamus, the upper brain stem, the striatum and the cortex.


CONCLUSIONS
The brain regions showing increased uptake in the human brain correspond to those in which vinpocetine has previously been shown to induce elevated metabolism and blood flow by PET clinical studies in patients with chronic ischaemic post-stroke condition.
Vas
Adám
A
Richter Gedeon Vegyészeti Gyár Rt., Budapest.
Sóvágó
Judit
J
Halldin
Christer
C
Sandell
Johan
J
Karlsson
Per
P
Kárpáti
Egon
E
Kiss
Béla
B
Cselényi
Zsolt
Z
Farde
Lars
L
Gulyás
Balázs
B
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000378:metabolism; D012016:Reference Values; D013788:Thalamus / Q000378:metabolism; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods; D014748:Vinca Alkaloids / Q000008:administration & dosage* / Q000378:metabolism*
D002250:Carbon Radioisotopes; D018696:Neuroprotective Agents; D014748:Vinca Alkaloids; C013983:vinpocetine