[Revision of the biological significance of the contact system].
Current concept of blood coagulation is divided into two stages: an "initiation" stage which is handled by tissue factor pathway, and an "augmentation" stage handled by intrinsic pathway beginning in factor XI. Recent studies have demonstrated that the contact system is a modulator for vascular biology with vascular tone regulation, anticoagulant, profibrinolytic, antiadhesive and proinflammatory functions. Changes of contact system are associated with sepsis, thrombosis, etc.
Liu
F Y
FY
Department of Physiology, Hunan Medical University, Changsha 410078.
He
S L
SL
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D005174:Factor XII / Q000502:physiology; D015956:Factor XIIa / Q000502:physiology; D006801:Humans; D019679:Kininogen, High-Molecular-Weight / Q000502:physiology*; D011288:Prekallikrein / Q000502:physiology*; D013925:Thromboplastin / Q000502:physiology
D019679:Kininogen, High-Molecular-Weight; D005174:Factor XII; D013925:Thromboplastin; D011288:Prekallikrein; D015956:Factor XIIa