An efficient and practical N-methylation of amino acid derivatives.
[reaction: see text] An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.
Prashad
Mahavir
M
Process Research and Development, Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA. mahavir.prashad@pharma.novartis.com
Har
Denis
D
Hu
Bin
B
Kim
Hong-Yong
HY
Repic
Oljan
O
Blacklock
Thomas J
TJ
D000596:Amino Acids / Q000138:chemical synthesis*; D008745:Methylation; D012972:Sodium Hydroxide / Q000737:chemistry; D013463:Sulfuric Acid Esters / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D013463:Sulfuric Acid Esters; D014867:Water; D012972:Sodium Hydroxide; C007482:dimethyl sulfate