title: Somatostatin receptor immunoreactivity in the eye of the adult newt (Pleurodeles waltlii Michan).
abstract: The neuropeptide somatostatin is found in the retina of many species, yet its role in the visual process remains to be elucidated. The aim of the present study was to examine the expression and cellular localization of somatostatin receptor subtypes (sst; sst(2A), sst(2B) and sst(3)) in the eye of the adult newt Pleurodeles waltlii using immunohistochemistry. sst(2A) immunoreactivity was observed in bipolar cells, in the inner segments of cone photoreceptors, as well as in the region corresponding to connecting cilia of rods. sst(2B) immunoreactivity was not detected. sst(3) immunostaining was localized most intensely in the inner segments of cones, and in cilia of rods. These results suggest that somatostatin acting via sst(2A) and sst(3) receptors may play an important role in retinal physiology of the lower vertebrates.
authors.affiliation: Institute of Developmental Biology, Russian Academy of Sciences, Moscow 117808, Russia.
authors.forename: Eleonora N
authors.initials: EN
authors.lastname: Grigoryan
authors.forename: Anna
authors.initials: A
authors.lastname: Vasilaki
authors.forename: Niki
authors.initials: N
authors.lastname: Mastrodimou
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Thermos
mesh_terms: D000818:Animals; D005123:Eye / Q000033:anatomy & histology / Q000378:metabolism*; D007150:Immunohistochemistry; D009281:Naphthalenes; D010999:Pleurodeles; D017481:Receptors, Somatostatin / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism; D012717:Sesquiterpenes
chemical_list: D009281:Naphthalenes; D017481:Receptors, Somatostatin; D012717:Sesquiterpenes; C093870:bipolal; C103631:somatostatin receptor 3; C106140:somatostatin receptor sst2A