title: Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology.
abstract: One of the fundamental molecules governing the survival of mammalian cells is oxygen. Oxygen has gained particular significance in tumor developmental biology and oncology. An increasingly diverse array of methods is now available to characterize tumor oxygenation. This Prospect will consider a new method, Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping (FREDOM), which we have recently developed for oximetry, examine application to a specific therapeutic example and place this technique in the context of other approaches.
authors.affiliation: Department of Radiology, U.T. Southwestern Medical Center, Dallas, Texas, USA. Ralph.Mason@UTSouthwestern.edu
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Mason
authors.forename: Sophia
authors.initials: S
authors.lastname: Ran
authors.forename: Philip E
authors.initials: PE
authors.lastname: Thorpe
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D017352:Echo-Planar Imaging / Q000379:methods*; D005466:Fluorocarbons; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D011379:Prognosis; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D005466:Fluorocarbons; C003005:hexafluorobenzene; D010100:Oxygen