Synthesis of an amino-functionalized model of the Fe-only hydrogenase active site.
A dinuclear 2Fe2S mimic 6 of the active site of the Fe-only hydrogenases has been synthesized. Complex 6 contains a free amino group which enables linkage to a protein backbone or to a redox active species for the study of electron transfer processes in proteins or in supramolecular systems. The structures of the complex 6 and its Boc-protected precursor 5 could be verified by X-ray crystallography.
Salyi
Szabolcs
S
Department of Organic Chemistry, Arrhenius Laboratory Stockholm University, Stockholm, Sweden.
Kritikos
Mikael
M
Akermark
Björn
B
Sun
Licheng
L
D000588:Amines / Q000737:chemistry*; D001665:Binding Sites; D006864:Hydrogenase / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000588:Amines; D007501:Iron; D006864:Hydrogenase