[Studies on nano-particle sols of hydroxyaptite and titanium dioxide for haemo-compatibility].
A biological evaluation is conducted for two types of nano-particle sols, hydroxyaptite(HAP) and titanium dioxide(TiO2). The results show that HAP sol significnatly prolongs the bleeding time and coagulation time of mice as well as the prothrombin time(PT) and partial thromboplastin time(PTT) of rats while TiO2 sol exhibits no such effects. Neither HAP sol nor TiO2 sol instigated in-vitro hemolysis of rabbit erythrocyte. However, both of the materials caused in-vitro aggregation of rabbit erythrocytes. The reason underlying the different results as to the two types of material is their specific stabilizer, heparin for HAP sol and PVC for TiO2 sol. We came to the conclusion that a biologically inert stablizer has no less significance than the nano-particle's very own nature in a nano-material's application prospect.
Chen
Xiao
X
Department of Pharmacology, Medical School of Wuhan University, Wuhan 430071, China.
Feng
Lingyun
L
Peng
Renxiu
R
Cao
Xianying
X
D000818:Animals; D001672:Biocompatible Materials; D017886:Durapatite / Q000009:adverse effects*; D005260:Female; D008297:Male; D051379:Mice; D036103:Nanotechnology; D010316:Particle Size; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D014025:Titanium / Q000009:adverse effects*; D014914:Whole Blood Coagulation Time
D001672:Biocompatible Materials; C009495:titanium dioxide; D017886:Durapatite; D014025:Titanium