[Experimental study on using diclofenac sodium or dionine topically to treat fibrinous membrane after intraocular lens implantation].
OBJECTIVE
To find a reasonable method for treating and preventing fibrinous membrane after intraocular lens (IOL) implantation by using diclofenac sodium or dionine topically.


METHODS
Forty-eight eyes of twenty-four adult pure bred New Zealand rabbits were divided into three groups randomly. Group A: rabits received diclofenac sodium eyedrops; Group B: rabbits received dionine eyedrops; Group C: controlled. All the eyes received lens extraction combined with posterior chamber intraocular lens implantation. The fibrinous membrane was observed after 1, 3, 5, 7, 14, 21 and 30 days postoperatively.


RESULTS
The fibrinous membran in Group A was less than that of Group B and Group C, (P < 0.05); the difference between group B and group C on fibrinous membrance was also statistically significant (P < 0.05).


CONCLUSIONS
The study suggests that both diclofenac sodium and the dionine eyedrops can treat fibrinous membrane after IOL implantation. The effect of diclofenac sodium is better than that of dionine.
Jia
S B
SB
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Tang
L S
LS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D004008:Diclofenac / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D005036:Ethylmorphine / Q000494:pharmacology* / Q000627:therapeutic use; D005122:Exudates and Transudates; D005260:Female; D005337:Fibrin; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D008297:Male; D008566:Membranes; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac; D005337:Fibrin; D005036:Ethylmorphine