[Characterization of chromatographic behavior of polar solutes of small molecules with lgI in reversed-phase liquid chromatography].
A new characterization parameter lgI, affinity constant, in reversed-phase liquid chromatography (RPLC) has been tested at several aspects with experimental data of polar n-alkyl alcohol homologoues and aromatic alcohol homologoues. The lgI values were compared with other physicochemical parameters of corresponding solutes, such as hydrophobic fragmental constant (lgf), van der Waals volume (Vw), molecular connectivity (chi). It was proved that lgI was also used for the characterization of solutes, mobile and stationary phases in RPLC. Moreover, it was also confirmed that lgI has the property of thermodynamic equilibriam constant.
Zhang
Wei-ping
WP
Shaanxi Province Key Laboratory of Modern Separation Science, Institute of Modern Separation Science, Northwest University, Xi'an 710069, China.
Gao
Juan
J
Bai
Quan
Q
Geng
Xin-du
XD
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D005233:Fatty Alcohols / Q000032:analysis / Q000737:chemistry; D000441:Hexanols / Q000032:analysis / Q000737:chemistry; D008962:Models, Theoretical; D008970:Molecular Weight; D012015:Reference Standards; D012996:Solutions; D013816:Thermodynamics
D005233:Fatty Alcohols; D000441:Hexanols; D012996:Solutions; C029383:n-decyl alcohol