Stereoselective determination and pharmacokinetics of dihydropyridines: an updated review.
All dihydropyridines, except nifedipine, have at least one chiral center, and their pharmacokinetics and clinical effects differ from one enantiomer to another. Chiral separation methods for dihydropyridines using chromatographic techniques are discussed. The stereoselective pharmacokinetics of dihydropyridine calcium antagonists were reviewed in detail in 1995. The present review article updates the methods for the stereoselective determination of dihydropyridines using chromatographic techniques and summarizes the pharmacokinetics of the dihydropyridines, including the newest drugs under development.
Inotsume
Nobuo
N
Department of Pharmacology and Therapeutics, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru 047-0264, Japan.
Nakano
Masahiro
M
D002121:Calcium Channel Blockers / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D002845:Chromatography / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods; D004095:Dihydropyridines / Q000032:analysis* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002121:Calcium Channel Blockers; D004095:Dihydropyridines