title: Synthesis and insecticidal activity of benzoheterocyclic analogues of N'-benzoyl-N-(tert-butyl)benzohydrazide: Part 2. Introduction of substituents on the benzene rings of the benzoheterocycle moiety.
abstract: A series of N'-benzoheterocyclecarbonyl-N-tert-butyl-3,5-dimethylbenzohydrazide analogues possessing a variety of substituents on the benzene rings of the benzoheterocyle moieties were synthesized and tested for their insecticidal activity. The introduction of a methyl group at the R1 position of the benzoheterocycle moiety strongly increased the insecticidal activity. Among the analogues synthesized, N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methyl-6-chromanecarbohydrazide showed the highest insecticidal activity (LC50 = 0.89 mg litre(-1)).
authors.affiliation: Agroscience Research Laboratories, Sankyo Co Ltd, 1041, Yasu, Yasu-cho, Yasu-gun, Shiga-ken 520-2342, Japan. sawada@br.sankyo.co.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sawada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yanai
authors.forename: Harumi
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Yokoi
authors.forename: Mikio
authors.initials: M
authors.lastname: Yanagi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Toya
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sugizaki
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Kato
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Shirakura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Yajima
authors.forename: Seiichirou
authors.initials: S
authors.lastname: Kodama
authors.forename: Akio
authors.initials: A
authors.lastname: Masui
mesh_terms: D000818:Animals; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006834:Hydrazines / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D015394:Molecular Structure; D018411:Spodoptera / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D006571:Heterocyclic Compounds; D006834:Hydrazines; D007306:Insecticides; C056565:1,2-dibenzoyl-tert-butylhydrazine