title: Occult orbital neuroblastoma detected after administration of an antitumor vaccine.
abstract: A 6-year-old girl with neuroblastoma developed swelling and erythema of her right upper eyelid following administration of an interleukin-2 and lymphotactin gene-modified allogeneic neuroblastoma cell vaccine. Computed tomography demonstrated a cystic lesion in the subperiosteal space. A biopsy of the mass showed necrotic neuroblastoma with minimal associated inflammation. To our knowledge, this case represents the first description of occult orbital metastases in a patient with neuroblastoma detected after administration of an antitumor vaccine.
authors.affiliation: Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Wilson
authors.forename: Darius M
authors.initials: DM
authors.lastname: Moshfeghi
authors.forename: Barrett G
authors.initials: BG
authors.lastname: Haik
authors.forename: Ann E
authors.initials: AE
authors.lastname: Haight
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
authors.forename: Raphael F
authors.initials: RF
authors.lastname: Rousseau
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bowman
mesh_terms: D019496:Cancer Vaccines / Q000008:administration & dosage*; D002481:Cellulitis / Q000175:diagnosis / Q000209:etiology; D019744:Chemokines, C; D002648:Child; D005094:Exophthalmos / Q000175:diagnosis / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D012795:Sialoglycoproteins / Q000276:immunology*; D014057:Tomography, X-Ray Computed; D014611:Vaccination
chemical_list: D019496:Cancer Vaccines; D019744:Chemokines, C; D007376:Interleukin-2; D008222:Lymphokines; D012795:Sialoglycoproteins; C092390:XCL1 protein, human; C018997:lymphotactin