Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report).
OBJECTIVE
This paper presents functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) findings in a monozygotic twin pair discordant for schizophrenia.


METHODS
Functional magnetic resonance imaging was used to determine hemispheric lateralization for speech and proton MRS (1H-MRS) was employed to assess the extent of putative insult to anterior hippocampus.


RESULTS
Despite concordant right handedness, subject with schizophrenia displayed bilateral activation in areas subserving speech with greater extent of the total activated area compared with the healthy twin. The affected twin displayed relative bilateral decrease in N-acetylaspartate/creatin concentration in the anterior hippocampus compared with the healthy one.


CONCLUSIONS
This is an evidence for non-genetic impairment of cerebral lateralization in monozygotic twin with schizophrenia.
Spaniel
F
F
Third Faculty of Medicine, Charles University Prague and Psychiatric Center Prague, Czech Republic. spaniel@pcp.lf3.cuni.cz
Hájek
T
T
Tintera
J
J
Harantová
P
P
Dezortová
M
M
Hájek
M
M
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D002540:Cerebral Cortex / Q000473:pathology* / Q000502:physiology*; D003401:Creatine / Q000032:analysis; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D013060:Speech; D014430:Twins, Monozygotic
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine