Pediatric reference ranges for zinc protoporphyrin.
OBJECTIVE
To determine pediatric reference ranges for zinc protoporphyrin (ZPP).


METHODS
The study was conducted in a large pediatric hospital on patient blood specimens (n = 6,478) (0-17 y) accrued from January 2001 to June 2002. The data was analyzed employing the Hoffman approach, which was computer adapted.


CONCLUSIONS
The 2.5(th) and 97.5(th) percentiles for children age 0 to 12 months were 9 to 40 microg/dL (16.6-73.6 micromol/mol heme) for female subjects and 8.5 to 34.5 microg/dL (15.6-63.5 micromol/mol heme) for males. The 97.5(th) percentiles decreased for the 13 to 24 months age group for females (32 microg/dL) (58.9 micromol/mol heme). There was a significant decrease in the 97.5(th) percentile for zinc protoporphyrin (ZPP) concentrations for the 5 to 9 yr age group, the 97.5(th) percentile being 30 microg/dL (55.2 micromol/mol heme) in both genders, which increased to 33.5 microg/dL (61.6 micromol/mol heme) in the 10 to 17 yr female age group but not for the males (31.5 microg/dL) (58.0 micromol/mol heme). The highest medians were 25.5 microg/dL (46.9 micromol/mol heme) for females, and 21.5 microg/dL (39.6 micromol/mol heme) for males in the 0 to 12 months age group.
Soldin
Offie Porat
OP
Soldin Research and Consultants, Inc., Bethesda, MD, USA. offie@gwu.edu
Miller
Maureen
M
Soldin
Steven J
SJ
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007855:Lead Poisoning; D008297:Male; D011524:Protoporphyrins / Q000097:blood*; D012016:Reference Values; D013997:Time Factors
D011524:Protoporphyrins; C017803:zinc protoporphyrin