title: The family and compliance in schizophrenia: the influence of clinical variables, relatives' knowledge and expressed emotion.
abstract: BACKGROUND
  . A variety of factors are related to compliance with medication in schizophrenia, but little attention has been paid to the role of families. Carers' knowledge or expressed emotion (EE) may be related to compliance. The aim of the present study was to evaluate the relevance of these two factors, as well as their relationships with other variables for the prediction of compliance.
  
  
  METHODS
  A sample of patient-carer pairs (N = 79) involved in a family intervention for schizophrenia trial was recruited. Compliance, symptoms, social functioning and attitudes to their carers were assessed in patients. Carers' EE, knowledge and psychopathology were also evaluated.
  
  
  RESULTS
  A number of factors were related to compliance, including carers' EE and patients' psychotic symptoms, which contributed independently to not taking medication. Carers' knowledge about schizophrenia and other groups of symptoms was not related to compliance.
  
  
  CONCLUSIONS
  EE may be an important factor to account for in the understanding of patients' compliance and the direction of the relationship between EE and compliance should be the subject of further study.
authors.affiliation: Department of Clinical Psychology, Manchester Mental Health Partnership, Wythenshawe Hospital.
authors.forename: W
authors.initials: W
authors.lastname: Sellwood
authors.forename: N
authors.initials: N
authors.lastname: Tarrier
authors.forename: J
authors.initials: J
authors.lastname: Quinn
authors.forename: C
authors.initials: C
authors.lastname: Barrowclough
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017028:Caregivers / Q000523:psychology; D019260:Expressed Emotion; D005190:Family / Q000523:psychology*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000175:diagnosis / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome