title: [Timing of surgery in infective endocarditis: impact on the outcome and recurrence].
abstract: Timing of surgery in infective endocarditis remains a challenge in the face of potential drug toxicity on one hand and recurrence of endocarditis on the other. The aim of the study was analysis of risk factors for hospital mortality and recurrent endocarditis. A total of 131 patients with infective endocarditis have been observed during 1999-2001. Eighty seven of them were male and 44 female with mean age of 50+/-16 years. Sixty three (48.1%) patients underwent surgery, remaining 68 (51.9%) were treated conservatively. Hospital mortality was 25.2%. Postoperative perivalvular leak was associated with culture negative endocarditis (p=0.09) as well as with positive valve culture (p=0.04). Recurrence was related to positive valve culture (p=0.08) and embolism (p=0.02). Increased risk of death was associated with neurologic, embolic, renal complications, myocardial abscess, NYHA IV f.cl. and extracardial surgery. According to the data obtained, optimal surgery time in the group appeared to be between 17 and 45 days after the diagnosis of infective endocarditis has been made (p=0.049).
authors.affiliation: Clinic of Cardiology, Kaunas University of Medicine Hospital, Eiveniu 2, 3007 Kaunas, Lithuania. aredar@hotmail.com
authors.forename: Reda
authors.initials: R
authors.lastname: Arzanauskiene
authors.forename: Petras
authors.initials: P
authors.lastname: Zabiela
authors.forename: Rimantas
authors.initials: R
authors.lastname: Benetis
authors.forename: Regina
authors.initials: R
authors.lastname: Jonkaitiene
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D003627:Data Interpretation, Statistical; D004452:Echocardiography; D004696:Endocarditis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome