[Bcl-2 and bax expression in rat cerebral ischemic preconditioning].
OBJECTIVE
To study the expression of apoptosis regulated genes bcl-2 and bax nocoprotein expression and its significance in rat cerebral ischemic preconditioning.


METHODS
With immunohistochemical assay, bcl-2 and bax expression were studied in rat brains which were divided into four groups: the sham-operation control group, the cerebral ischemic group and the cerebral ischemic preconditioning group.


RESULTS
Bcl-2 oncoprotein was induced in cerebral ischemic preconditioning control group. Bax oncoprotein expression had no obviously difference in four groups.


CONCLUSIONS
The expression of bcl-2 and bax oncoprotein after sublethal ischemic preconditioning might be associated with the preconditioning protection against neuronal damage following subsequent lethal ischemia.
Wang
E
E
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Guo
Q L
QL
Tan
X J
XJ
D000818:Animals; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000235:genetics / Q000378:metabolism*; D019194:Ischemic Preconditioning; D008297:Male; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein
C494828:Bax protein, rat; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein