title: Candida-induced stomatopyrosis and its relation to diabetes mellitus.
abstract: BACKGROUND
  Glycaemic disorders and oral candidosis can be accompanied by burning mouth sensations. However, no clear relation between all three disorders is known.
  
  
  METHODS
  Seventy-two native Upper-Austrians with burning mouth sensations were examined and smears for Candida estimation were taken from the spots where the sensations were felt. All patients with previously unknown diabetes mellitus (DM) were subjected to an oral glucose tolerance test (OGTT). Use of glucocorticoid-containing anti-asthmatic sprays and the body mass index (BMI) were determined.
  
  
  RESULTS
  Of the examined non-inhalers of sprays, 52% had increased candidal density. A correlation between that increase and type 2 DM was found. The burning sensations in all patients with increased candidal density subsided completely after anti-mycotic therapy.
  
  
  CONCLUSIONS
  The perception of burning sensations was hypothesised to occur via stimulation of the capsaicin (vanilloid) receptor by Candida metabolites. The Candida-induced stomatopyrosis should be regarded as a single symptom indicating (predisposition to or established) type 2 DM in non-inhalers of the concerned population.
authors.affiliation: Department of Electron Microscopy, University of Salzburg, Salzburg, Austria. lvitkov@yahoo.com
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Vitkov
authors.forename: Raimund
authors.initials: R
authors.lastname: Weitgasser
authors.forename: Matthias
authors.initials: M
authors.lastname: Hannig
authors.forename: Karl
authors.initials: K
authors.lastname: Fuchs
authors.forename: Wolf Dietrich
authors.initials: WD
authors.lastname: Krautgartner
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage; D000935:Antifungal Agents / Q000627:therapeutic use; D015992:Body Mass Index; D002054:Burning Mouth Syndrome / Q000188:drug therapy / Q000382:microbiology*; D002180:Candidiasis, Oral / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D015169:Colony Count, Microbial; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug / Q000502:physiology; D012737:Sex Factors
chemical_list: D018927:Anti-Asthmatic Agents; D000935:Antifungal Agents; D005938:Glucocorticoids; D011955:Receptors, Drug