[Studies on degradation of poly-(propyl,3-hydroxypropyl)-DL-asparamide and release of conjugate linking aspirin in vivo and in vitro].
Two polyasparamide derivants having different hydrophilicities were selected to be degraded in vivo and in vitro. The results demonstrate that the degradation process of polyasparamide is enzymatic hydrolysis. Materials with different hydrophobicities are different in degradation rate and the same material has different metabolic rates in the planting position, kidney and liver. The release results of two polymeric drugs indicate that protease is of advantage to release of drug, and hydrophobicity of material is also an advantage to the release.
Zhou
T
T
Department of Food Science and Engineering, Ningbo University, Ningbo 315211.
Wang
B
B
Tang
G
G
Chen
Q
Q
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D001241:Aspirin / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits
D004337:Drug Carriers; D010455:Peptides; C117293:poly(3-hydroxypropyl-propyl)asparamide; D001224:Aspartic Acid; D001241:Aspirin