Age and body mass related changes of cardiovascular risk factors in women with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is considered a metabolic disorder closely related to obesity, insulin resistance (IR), hyperinsulinemia and unfavorable lipid profile, all increasing the risk for the occurrence of cardiovascular diseases. The aim of this study was to assess age and body mass index (BMI) related changes of cardiovascular risk factors in 90 women with PCOS. The cut-off age point was 30 years and for BMI 27.8 kg/m2. In all patients systolic and diastolic blood pressure (BP), metabolic parameters comprising values of glucose and insulin during oral glucose tolerance test (OGTT), and basal lipid values were determined. Significant increase in blood pressure (BP) indices, basal insulin values and insulin resistance (IR) assessed by HOMA model were observed with aging and the increase of BMI, while the parameters of glucose metabolism, total cholesterol and triglycerides were significantly elevated only with aging. However, the correlation between the indices of arterial blood pressure, and lipid and glucose metabolism parameters occurred only in patients over 30 years of age, pointing to the causative relation and the consequent deterioration of IR and lipid profile with aging, influencing cardiovascular function in women with PCOS.
Macut
Duro
D
Institute of Endocrinology, Diabetes and Diseases of Metabolism, University of Belgrade Medical School, Belgrade.
Micić
Dragan
D
Parapid
Biljana
B
Cvijović
Goran
G
Sumarac
Mirjana
M
Kendereski
Aleksandra
A
Milić
Natasa
N
Tulić
Lidija
L
Muharemagić
Azra
A
Zorić
Svetlana
S
Pejković
Danica
D
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D012307:Risk Factors
D001786:Blood Glucose; D008055:Lipids