title: Cardiac troponin T and myocardial injury during routine cardiac catheterisation in children.
abstract: BACKGROUND
  This study aims to investigate whether intracardiac catheterization produces myocardial damage on pediatric heart.
  
  
  METHODS
  Five blood samples were collected (basal, immediate post procedure, at 4, 12 and 24 h after the procedure) for troponin T and creatine kinase MB (CKMB) from 48 consecutive patients (age: 5.34+/-6.03 years). The effect of age, duration of procedure, pulmonary hypertension, cyanosis, and medication taken for congestive heart failure on the levels of troponin T and CKMB were sought.
  
  
  RESULTS
  The increase in CKMB (basal CKMB: 3.93+/-3.70 ng/ml; peak CKMB: 8.68+/-10.89 ng/ml; P<0.0001) and troponin levels (basal troponin: 0.002+/-0.003 ng/ml; peak troponin: 0.11+/-0.23 ng/ml; P<0.0001) over time was significant in the study group. Additionally younger patients (</=1 year), patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg), longer procedure time (>30 min), and patients taking anti-congestive heart failure therapy had significantly higher levels of CKMB and troponin (P>0.05).
  
  
  CONCLUSIONS
  All patients undergoing cardiac catheterization are under risk of myocardial injury, and younger patients with pulmonary hypertension and especially with compensated cardiac failure have increased risk of myocardial damage, and need to be handled carefully.
authors.affiliation: Pediatric Cardiology Unit, Hacettepe University, Ihsan Dogramaci Children's Hospital, Sihhiye 06100, Ankara, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Alehan
authors.forename: Canan
authors.initials: C
authors.lastname: Ayabakan
authors.forename: Alpay
authors.initials: A
authors.lastname: Celiker
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests; D015331:Cohort Studies; D003402:Creatine Kinase / Q000032:analysis* / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis; D006335:Heart Injuries / Q000097:blood* / Q000209:etiology; D006801:Humans; D007223:Infant; D015601:Injury Severity Score; D007527:Isoenzymes / Q000032:analysis* / Q000097:blood; D008297:Male; D011336:Probability; D011379:Prognosis; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D020107:Troponin T / Q000032:analysis* / Q000097:blood
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form