title: The effects of an additive small amount of a low residual diet against total parenteral nutrition-induced gut mucosal barrier.
abstract: BACKGROUND
  Total parenteral nutrition (TPN) negatively influences the gut mucosal barrier. It has been suggested that enteral nutrition is effective against the harmful influence.
  
  
  METHODS
  Forty-eight male Donryu rats underwent placement of a central venous catheter and tube gastrostomy. They were divided into six groups, receiving isocaloric nutrients in various proportions of PN and a low residual diet (LRD) for 7 days.
  
  
  RESULTS
  Intestinal permeability, villous height and crypt depth, and number of secretory IgA-positive cells in the villus were measured. Intestinal permeability was significantly reduced in rats receiving an LRD corresponding to more than 15% of total caloric intake. Gut morphological structure was maintained in rats receiving an LRD corresponding to more than 10%. A higher number of IgA-positive cells was observed in rats receiving an LRD corresponding to more than 15%.
  
  
  CONCLUSIONS
  A small amount of LRD could prevent decreases in gut mucosal integrity. There was a stepwise defense mechanism in the gut mucosal barrier.
authors.affiliation: Department of Surgery, Kanazawa University Faculty of Medicine School of Medicine, Japan. kouji0470326@yahoo.co.jp
authors.forename: Kouji
authors.initials: K
authors.lastname: Ohta
authors.forename: Kenji
authors.initials: K
authors.lastname: Omura
authors.forename: Kathuyasu
authors.initials: K
authors.lastname: Hirano
authors.forename: Eiji
authors.initials: E
authors.lastname: Kanehira
authors.forename: Nobuki
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kato
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kawakami
authors.forename: Go
authors.initials: G
authors.lastname: Watanabe
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000097:blood* / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D004032:Diet; D004195:Disease Models, Animal; D002149:Energy Intake; D004734:Energy Metabolism / Q000502:physiology*; D007070:Immunoglobulin A / Q000032:analysis; D007150:Immunohistochemistry; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D009092:Mucous Membrane / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D010539:Permeability; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007070:Immunoglobulin A; D006631:Amine Oxidase (Copper-Containing)