[Microsatellite instability: a potential tool for the study of life sciences].
Microsatellites are simply repeated nucleotide sequences scattered throughout the human genome. They are highly polymorphic among human population and inherited in a stable manner. The microsatellite instability (MI) is highly polymorphic, which is associated with the defects in DNA mismatch repair genes. MI has been widely used by scientists to study the tumorigenesis. On the basis of their findings, a "mutator that mutates the other mutator" model for tumorigenesis has been proposed. MI is also a potential tool for the study of genetics, aging and other life sciences.
Ding
Y
Y
Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083.
Tong
T J
TJ
D020137:Base Pair Mismatch / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats / Q000235:genetics*; D000074081:MutS Homolog 3 Protein; D009154:Mutation; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics
D004268:DNA-Binding Proteins; C078444:MSH3 protein, human; D000074081:MutS Homolog 3 Protein