[Research on the mechanism of neuronal apoptosis in Alzheimer's disease and the effects of tetrohydroberberine on the apoptosis].
Apoptosis in Alzheimer's disease(AD) was studied by the techniques of immunohistochemistry, neuronal culture and patch clamp. The hippocampal neuronal apoptosis induced by beta-amyloid peptide (beta-AP) and its ionic mechanism were also observed. The results showed that neuronal apoptosis did exist in AD brains and beta-AP might induce the apoptosis by blocking the voltage-dependent K+ and Na+ channels, which were enhanced by nitric oxide(NO). In addition, tetrohydroberbine could protect against the apoptosis induced by beta-AP by reducing hippocampal neuronal intracellar free Ca2+.
Xu
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Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080.
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002478:Cells, Cultured; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000502:physiology
D016229:Amyloid beta-Peptides; D001599:Berberine; C004645:canadine