Analysis of 'SHENMAI' injection by HPLC/MS/MS.
An HPLC/MS/MS method was developed for the analysis of 'SHENMAI' injection, composed of red ginseng and ophiopogon. The constituents of 'SHENMAI' were found to be similar with those of ginseng and 39 ginsenosides were detected. By the studies of MS and MS/MS spectra and the comparison with literature data, most of these ginsenosides were identified. Based on this study, suggestions were put forward to improve the quality control system of 'SHENMAI' injection.
Haijiang
Zhang
Z
Institute of Pharmaceutical Engineering, College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, PR China.
Yongjiang
Wu
W
Yiyu
Cheng
C
D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D031441:Ophiopogon / Q000737:chemistry*; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007202:Indicators and Reagents; D010936:Plant Extracts; D012997:Solvents; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination