[Phagocytic activity of mouse peritoneal macrophages under administration of bacterial vaccines and prospidin].
Phagocytic activity of peritoneal macrophages in cases of separate and combined injections of killed bacterial vaccines and prospidin has been studied in the work. As a result of researches conducted, it has been found out that the injection of vaccines together with prospidin makes it possible to reduce an inhibiting effect of prospidin on phagocytic activity of monocyte-macrophagal cells; first of all it concerns their digestive activity. Thus, the immunodepressing effect of antiblastome drugs may be reduced with the help of injection of killed bacterial vaccines which stimulate nonspecific factors of organism protection, including antineoplastic ones.
Pavlenko
N V
NV
Kharkov State Medical University, 4 Lenin Pr., Kharkov, 61078, Ukraine.
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004347:Drug Interactions; D004926:Escherichia coli / Q000276:immunology*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D011447:Prospidium / Q000008:administration & dosage / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*
D001428:Bacterial Vaccines; D011447:Prospidium