[Telomerase activity in bladder cancer tissues].
OBJECTIVE
To study the correlation between telomerase and bladder cancer.


METHODS
The telomerase activity was detected by telomerase PCR ELISA in 41 cases of bladder cancer tissues and 23 cases of non-cancerous bladder tissues.


RESULTS
The telomerase activity was positive in 34 cases of bladder cancer tissues (82.9%) and 1 case of non-cancerous tissues (4.3%); the difference of positive rate was significant (P < 0.01).


CONCLUSIONS
Telomerase activity is related with bladder cancer closely; telomerase activation may be an important molecular step in the initiation and development of bladder cancer; telomerase may be an excellent molecular biomarker in finding bladder cancer at an early stage and in postoperative following-up.
Tang
Z Y
ZY
Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.
Yi
H
H
Chen
B L
BL
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019098:Telomerase / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology*
D019098:Telomerase