The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae.
A small number of pneumococcal clones dominate the population of antibiotic-resistant pneumococci. The emergence of fluoroquinolone resistance in these clones predicts the dissemination of fluoroquinolone resistance in countries where the clones are present and community use of fluoroquinolones for respiratory infections is common. The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes.
Klugman
K P
KP
Department of International Health, Rollins School of Public Health, Division of Infectious Diseases, School of Medicine, Emory University, 1518 Clifton Road NE, Room 764, Atlanta, GA 30322, USA. kklugma@sph.emory.edu
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use; D002999:Clone Cells / Q000187:drug effects / Q000502:physiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones; D005822:Genetic Vectors / Q000235:genetics*; D006801:Humans; D017354:Point Mutation / Q000187:drug effects / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones