[Effects of angiotensin II on proliferation and expression of interleukin-6 of human kidney fibroblasts].
OBJECTIVE
To investigate the effects of Angiotensin(Ang) II on the proliferation and expression of Interleukin (IL)-6 in human kidney fibroblasts(KFB).


METHODS
The human KFB were cultured and identified, the proliferation of KFB was measured by MTT, and the level of IL-6 was measured by radioimmunoassay(RIA).


RESULTS
Angiotensin II could stimulate the proliferation of KFB and enhance the expression of IL-6 in protein level on KFB.


CONCLUSIONS
Angiotensin II can stimulate KFB's proliferation and enhance the expression of IL-6 of KFB. These findings suggest that Ang II might play a part in the mechanisms for modulating tubulointerstitial changes and induceing renal fibrosis.
Qu
S
S
Department of Nephrology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Wang
Z
Z
Fang
Q
Q
Chen
G
G
D000804:Angiotensin II / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005333:Fetus; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D007668:Kidney / Q000166:cytology*
D015850:Interleukin-6; D000804:Angiotensin II