(-)-Axinyssene: a novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp.
[structure: see text] A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5',9'-dimethyl-1'-methylene-4',8'-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.
Kodama
Kota
K
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Higuchi
Ryuichi
R
Miyamoto
Tomofumi
T
Van Soest
Rob W M
RW
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D002455:Cell Division / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013057:Spectrum Analysis; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D003603:Cytotoxins; D004224:Diterpenes; C474724:axinyssene