[Cochlear cytotoxic activity of cisplatin in experimentation animals. A study using scanning electron microscopy].
Cisplatin is an antitumoral agent commonly used in the treatment of different solid tumors. Its use induces adverse effects like oto- and nephrotoxicity due to acute renal failure. This makes it a suitable drug when creating an experimental model of ototoxicity. Our aim is to study the cellular lesions induced in the cochlea of the rat and the guinea pig by variable doses of cisplatin injected intraperitoneally, after short, middle, and long term survival, by means of scanning electronic microscopy. Results show the global effect of the cells of the organ of Corti with a more intense initial damage of the supporting cells, continuing with the late effect of the sensorial cells.
Ramírez Camacho
R
R
Servicio de Otorrinolaringología, Clínica Puerta de Hierro, UAM, Madrid. rramirezc@seorl.org
García Berrocal
J R
JR
Trinidad
A
A
Martín Marero
A
A
Buján
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005260:Female; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D002945:Cisplatin