Evidence for another tumor suppressor gene at 17p13.3 distal to TP53 in hepatocellular carcinoma.
Loss of 17p is one of the most frequent chromosomal alterations in primary hepatocellular carcinoma (HCC). In the present study, the association between loss of 17p and TP53 mutation was analyzed in 94 primary HCC of Chinese patients. Loss of one allele at 17p13.3 distal to the TP53 gene was observed in 48 of 94 HCC (51%), whereas loss of heterozygosity (LOH) at 17p13.1 near the TP53 gene was detected in 30 of 94 HCC (32%) and TP53 mutation was detected in only 22 of 94 HCC (23%). High frequency of LOH at 17p13.3 and relatively low frequency of TP53 mutation in the present study indicate that loss of function of a putative tumor suppressor gene at 17p13.3 may play a more important role than TP53 in HCC development.
Guan
Xin Yuan
XY
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China. xyguan@hkucc.hku.hk
Sham
Jonathan S T
JS
Tai
Lai Shan
LS
Fang
Yan
Y
Li
Hong
H
Liang
Qiwan
Q
D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002681:China; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics* / Q000648:ultrastructure; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D019656:Loss of Heterozygosity; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational