[Effects of bite force loss on the expression of IL-6 mRNA in rat periodontium].
OBJECTIVE
The aim of this study is to evaluate the expression of IL-6 mRNA in rat periodontal cells under normal bite force and without bite force, and to explain periodontal remodeling from the molecular level.


METHODS
Animal models with normal bite force and without bite force were established by using Wistar rats. In situ hybridization technique was applied to detect changes of IL-6 mRNA expression in rat periodontal tissue.


RESULTS
Without bite force, the expression level of IL-6 mRNA increased significantly in periodontal cells.


CONCLUSIONS
This study initially investigates the molecular mechanism of periodontal remodeling, and suggests that the histological morphology may be closely related to the mechanical stimulation.
Yuan
L
L
College of Stomatology, West China University of Medical Sciences.
Zhao
Y
Y
Zhou
W
W
D000818:Animals; D001732:Bite Force; D005347:Fibroblasts / Q000378:metabolism; D017403:In Situ Hybridization; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D010006:Osteoblasts / Q000378:metabolism; D010519:Periodontium / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D015850:Interleukin-6; D012333:RNA, Messenger