title: N-CAM expression and localization in PC12 cells modulated by extracellular peptides.
abstract: The neural cell adhesion molecules (N-CAMs) play an important role in mediating cell-cell interactions in the nervous system. Different isoforms of these membrane proteins are involved in the formation of the neuronal network and in the dynamic phases of neuronal plasticity. We studied the early stages of the pseudo neuronal differentiation of PC12 cells induced by a class of small acidic peptides capable of modulating gene expression in these cells. The data presented here indicate that peptides with specific sequences induce an increase in N-CAM mRNA expression and protein translocation to the plasma membrane to a comparable degree as NGF.
authors.affiliation: Dipartimento di Scienze del Farmaco, Laboratorio di Fisiologia Cellulare, Università G. d'Annunzio, 66013 Chieti, Italy. mariggio@unich.it
authors.forename: Maria A
authors.initials: MA
authors.lastname: Mariggiò
authors.forename: Simone
authors.initials: S
authors.lastname: Guarnieri
authors.forename: Stefania
authors.initials: S
authors.lastname: Mariggiò
authors.forename: Caterina
authors.initials: C
authors.lastname: Morabito
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Gianfranceschi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Fanò
mesh_terms: D000818:Animals; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D016716:PC12 Cells; D010455:Peptides / Q000378:metabolism*; D051381:Rats
chemical_list: D019006:Neural Cell Adhesion Molecules; D010455:Peptides