Sensitizing capacity and cross-reaction pattern of the isomers of diglycidyl ether of bisphenol F in the guinea pig.
In this study, the sensitizing capacities of the 3 main low-molecular-weight isomers of epoxy resins based on diglycidyl ether of biphenol F (DGEBF) were investigated in a guinea pig maximization test (GPMT). The isomers are p,p'-DGEBF, o,p'-DGEBF, and o,o'-DGEBF. The sensitization capacities were compared to diglycidyl ether of bisphenol A (DGEBA), which is the main constituent in the most common epoxy resin. The cross-reaction pattern between all 4 compounds was also investigated. It was found that all 3 DGEBF isomers were potent sensitizers. It was also found that p,p'-DGEBF, o,p'-DGEBF, and DGEBA cross-reacted with one another, and that animals induced with o,o'-DGEBF reacted significantly only to o,p'-DGEBF, but not to the other 2 DGEBF isomers or DGEBA.
Pontén
A
A
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden. ann.ponten@skane.se
Zimerson
E
E
Sörensen
O
O
Bruze
M
M
D000485:Allergens / Q000009:adverse effects* / Q000737:chemistry; D000818:Animals; D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000473:pathology; D004195:Disease Models, Animal; D004852:Epoxy Compounds / Q000009:adverse effects* / Q000737:chemistry; D006168:Guinea Pigs; D007428:Intradermal Tests; D007536:Isomerism
D000485:Allergens; D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; C423722:bisphenol F diglycidyl ether