title: Catalytic asymmetric silane alcoholysis: practical access to chiral silanes.
abstract: A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Darby R
authors.initials: DR
authors.lastname: Schmidt
authors.forename: Steven J
authors.initials: SJ
authors.lastname: O'Malley
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D012821:Silanes / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000475:Alkenes; D000480:Alkynes; D012821:Silanes