title: Chromosome 6 abnormalities are recurrent in synovial chondromatosis.
abstract: Synovial chondromatosis, a lesion composed of multiple nodules of cartilage involving articular or tendon sheath synovial membranes, has traditionally been considered a metaplastic condition. A specific or characteristic chromosomal anomaly has not yet been identified in synovial chondromatosis. Cytogenetic and molecular cytogenetic analyses of three cases of synovial chondromatosis revealed clonal karyotypic abnormalities in all three cases including structural abnormalities of chromosome 6 in two. Anomalies of chromosome 6 have been observed in three of five previously reported synovial chondromatosis cases. These findings support a neoplastic origin for synovial chondromatosis and suggest that chromosome 6 aberrations are recurrent in this lesion.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Emilie P
authors.initials: EP
authors.lastname: Buddingh
authors.forename: Pamela
authors.initials: P
authors.lastname: Krallman
authors.forename: James R
authors.initials: JR
authors.lastname: Neff
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015838:Chondromatosis, Synovial / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics* / Q000648:ultrastructure; D002999:Clone Cells / Q000648:ultrastructure; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D012303:Ring Chromosomes; D014178:Translocation, Genetic