title: [Bilateral diffuse uveal melanocytic proliferation associated with systemic carcinoma: two case reports].
abstract: Diffuse uveal melanocytic proliferation is a rare paraneoplastic syndrome resulting in rapid bilateral visual loss in patients with systemic carcinoma, caused by proliferation of benign melanocytes within the choroid and the ciliary body. More often visual impairment is due to retinal detachment and cataract. The authors report two cases of presumed diffuse uveal melanocytic proliferation. The first patient was a 74-year-old man with a history of colic carcinoma and hemangioendothelioma of the liver who presented with bilateral multiple nevi of the choroid and extrascleral melanic nodule. The second patient was a 59-year-old woman who presented bilateral multiple nevi of the choroid and a history of carcinoma of the thyroid treated by thyroidectomy 2 years before. There was no evidence of systemic melanoma in either patient. Our two patients showed slow progression with no visual impairment and a longer survival than those described in the literature.
authors.affiliation: Consultation d'Ophtalmologie, Institut Gustave Roussy, Villejuif, France.
authors.forename: E
authors.initials: E
authors.lastname: Frau
authors.forename: M
authors.initials: M
authors.lastname: Lautier-Frau
authors.forename: M
authors.initials: M
authors.lastname: Labetoulle
authors.forename: O
authors.initials: O
authors.lastname: Kirch
authors.forename: F
authors.initials: F
authors.lastname: Rumen
authors.forename: S
authors.initials: S
authors.lastname: Cardine
authors.forename: H
authors.initials: H
authors.lastname: Offret
mesh_terms: D000368:Aged; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D014602:Uvea / Q000473:pathology*