Drug interaction in a renal transplant patient: cyclosporin-Neoral and orlistat.
An overweight 56-year-old type II diabetic on peritoneal dialysis (body mass index 35 kg/m(2)) was taking Orlistat for some months up until live-unrelated renal transplantation. Despite oral cyclosporin A (CyA) for 48 hours pretransplantation, it was very difficult to achieve adequate CyA blood levels for the first week postengraftment despite the use of much larger oral CyA doses. After opening his bowels on day 7, and the use of 3 days intravenous CyA, good CyA blood levels were achieved then maintained with conventional oral doses. The authors believe that this case shows important interactions between CyA and Orlistat.
Evans
Sally
S
Department of Nephrology and Transplantation, Guy's Hospital, London, England.
Michael
Robson
R
Wells
Hayley
H
Maclean
Douglas
D
Gordon
Isabel
I
Taylor
John
J
Goldsmith
David
D
D000284:Administration, Oral; D019440:Anti-Obesity Agents / Q000378:metabolism / Q000627:therapeutic use; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D007783:Lactones / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy; D000077403:Orlistat
D019440:Anti-Obesity Agents; D007166:Immunosuppressive Agents; D007783:Lactones; D016572:Cyclosporine; D000077403:Orlistat