title: Daily variations in ceftriaxone pharmacokinetics in rats.
abstract: The aim of this study was to determine whether the time of day ceftriaxone was administered modified its pharmacokinetics. Ceftriaxone was given intraperitoneally at either 0400, 1000, 1600, and 2200 h to Sprague-Dawley rats synchronized under a light-dark cycle of 12 h of light and 12 h of dark. Pharmacokinetic parameters were analyzed for the presence of a 24-h rhythm. Results showed significant daily variations (P < 0.05) in ceftriaxone clearance, with the highest values during the dark phase. It is concluded that time-dependent variations in ceftriaxone pharmacokinetics may affect the therapeutic efficacy of current once-daily dosing schedules.
authors.affiliation: Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina. rebuelto@fvet.uba.ar
authors.forename: M
authors.initials: M
authors.lastname: Rebuelto
authors.forename: L
authors.initials: L
authors.lastname: Ambros
authors.forename: M
authors.initials: M
authors.lastname: Rubio
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002909:Chronobiology Phenomena / Q000502:physiology; D005260:Female; D006207:Half-Life; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002443:Ceftriaxone