Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21.
Human personality traits are moderately heritable but only recently have specific polymorphisms been associated with particular personality dimensions especially anxiety-related and novelty-seeking traits. The first genome-wide scan for personality traits was recently carried out by Cloninger et al. [1998: Am J Med Genet 81:313-317] and his colleagues and they reported that a region on 8p21 showed linkage to TPQ Harm Avoidance, an anxiety-related personality trait. Towards replicating and extending these results, we examined both 8p21 and two additional chromosomal regions (1q21-24 and 22q12-13) for linkage to TPQ personality traits by genotyping at least three microsatellite markers in each region in a group of 384 sibling pairs. We found evidence for linkage to TPQ HA at 8p21-23 (Lod score = 2.907) confirming in an independent sample the initial findings by Cloninger and his colleagues.
Zohar
Ada H
AH
The Ruppin Institute of Higher Education, Emek Hefer 40250, Israel.
Dina
Christian
C
Rosolio
Naama
N
Osher
Yamima
Y
Gritsenko
Inga
I
Bachner-Melman
Rachel
R
Benjamin
Jonathan
J
Belmaker
Robert H
RH
Ebstein
Richard P
RP
D001008:Anxiety Disorders / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010551:Personality / Q000235:genetics*; D035781:Siblings; D011795:Surveys and Questionnaires