title: [Modulation and implications in pathogenesis of interferon gamma receptor 1 in patients with chronic hepatitis B].
abstract: OBJECTIVE
  To study the possible differences in the interferon gamma receptor (IFN-gamma R1) response among a variety of clinical types in patients with chronic hepatitis B (CHB) and implications in pathogenesis.
  
  
  METHODS
  The serum level of IFN-gamma and the expression level of IFN-gamma R1 in peripheral leucocytes, from 53 CHB patients, were examined by ELISA and flow cytometry respectively, which were compared with the baseline levels of 15 healthy controls and were performed correlation analysis with alanine aminotransferase (ALT), total bilirubin (TBil) in serum and morphological change in hepatic tissues.
  
  
  RESULTS
  The results showed that the level of IFN-gamma R1 (28.89% 11.77%) expressed on the membranes of lymphocytes in CHB patients, which correlated with liver inflammation (r=0.621, P<0.01) and serum TBil level (r=0.575, P<0.01), was much higher than that (9.23% 1.30%) of the healthy controls (Z=3.988, P<0.05), and no obvious difference on the membranes of leucocytes. The serum levels of IFN-gamma in patients with cirrhosis and severe hepatitis were higher than those of healthy controls. And the two was no difference from each other, but the standard deviation in each group was relatively large.
  
  
  CONCLUSIONS
  These findings suggest that the IFN-gamma signal transduction pathway is modulated through up-regulating the expression of IFN-gamma R1 on the membranes of lymphocytes, which takes part in the immuno-pathogenesis in CHB patients.
authors.affiliation: Institute of Infectious Diseases, the First Affiliated Hospital Zhejiang University, Hangzhou 310003, China.
authors.forename: Gong-ying
authors.initials: GY
authors.lastname: Chen
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Min-wei
authors.initials: MW
authors.lastname: Li
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Liu
authors.forename: Zhong-rong
authors.initials: ZR
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D017471:Receptors, Interferon / Q000097:blood*; D000096743:Interferon gamma Receptor
chemical_list: D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor