Synthesis of milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27, delta(2,3),delta(4,26)-milbemycins A3, A4 from milbemycins A3, A4, and their acaricidal activities.
Chemical derivation methods to prepare 26-acyloxy and 26-hydroxymilbemycins, which had been reported as natural products, milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27 from milbemycins A3, A4 were reported. Delta(2,3),delta(4,26)-milbemycins A3, A4, which had also been reported as natural products, were further prepared from milbemycins A3, A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
Tsukiyama
Takahiro
T
Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd. 1041 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@yasu.sankyo.co.jp
Kajino
Hisaki
H
Kajino
Fumie
F
Furuta
Satoru
S
Tsukamoto
Yoshihisa
Y
Sato
Kazuo
K
Kinoshita
Ayako
A
Ichinose
Reiji
R
Tanaka
Keiji
K
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D007887:Fabaceae; D007306:Insecticides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides; D018515:Plant Leaves; D040102:Tetranychidae
D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin