[Determination of heroin metabolites in biological fluids, tissues and hair of heroin addicts using GC/MS-SIM].
Using GC/MS-SIM, we examined morphine distribution in human bodies of 2 delayed death cases and analyzed content of morphine and 6-acetylmorphine (MAM) in hair specimens of 7 cases. After hydrolysis and extraction, MOR and 6-MAM were derived with acetic anhydride or BSTFA and then the derivatives were qualitatively and quantitatively analyzed by GC/MS-SIM. The results indicated that urine, bile and liver were the best samples to reveal the heroin-related deaths. Hair analysis has its unique advantage for its long time of abusing monitor, compared to biological fluids.
Xiang
P
P
Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063, P. R. China.
Shen
M
M
Wu
H J
HJ
Huang
Z J
ZJ
D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D003932:Heroin / Q000378:metabolism*; D006556:Heroin Dependence / Q000378:metabolism; D006801:Humans; D008297:Male; D009020:Morphine / Q000032:analysis*; D009022:Morphine Derivatives / Q000032:analysis*
D009022:Morphine Derivatives; D003932:Heroin; D009020:Morphine; C026979:6-O-monoacetylmorphine