[Research progress in natural killer cell receptors].
Natural killer cell expresses two kinds of recognition receptors with contrary functions: killer cell activatory receptors (KAR) and killer cell inhibitory receptors (KIR). KIR can interact with MHC I type molecular-self nonself peptide complex expressed on self cell surface, and produce inhibitory signals which can prevent the activation of KAR, thereby preventing the cytotoxicity of NK cells. NK cell will trigger effector functions(cytolysis) by KAR, if target cell loses appropriate ligands recognized by KIR. In this article we will review the research progress in the structure of these receptors, their recognition and signal transduction mechanisms.
Ying
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HY
College of Life Science, Zhejiang University, Hangzhou 310012.
Shen
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X
Ding
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D000818:Animals; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D011971:Receptors, Immunologic / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction
D011971:Receptors, Immunologic