An integrated computational pipeline and database to support whole-genome sequence annotation.
We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.
Mungall
C J
CJ
Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. cjm@fruitfly.org
Misra
S
S
Berman
B P
BP
Carlson
J
J
Frise
E
E
Harris
N
N
Marshall
B
B
Shu
S
S
Kaminker
J S
JS
Prochnik
S E
SE
Smith
C D
CD
Smith
E
E
Tupy
J L
JL
Wiel
C
C
Rubin
G M
GM
Lewis
S E
SE
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D016678:Genome; D006801:Humans; D020407:Internet; D012985:Software Design