Diacylglycerol on lipid metabolism.
OBJECTIVE
Diacylglycerol is an intermediate product of triacylglycerol hydrolysis and comprises up to 10% of glycerides in plant-derived edible fats and oils. Recent developments in oil chemistry have led to the availability of a novel diacylglycerol oil for clinical studies. Recent research has shown that the oil containing 70% of unusual 1,3- species has metabolic characteristics distinct from those of triacylglycerol of similar fatty acid composition. This review summarizes recent research in humans and experimental animals into the metabolic effects and possible mechanisms of action of this oil.


RESULTS
Consumption of the oil affects lipid metabolism including lowering of plasma triacylglcerol, decreases postprandial lipemia and reduces body fat mass, compared with triacylglcerol. As the fatty acids of the two oils are similar, the metabolic differences reside in their structural differences.


CONCLUSIONS
It is still uncertain whether longer term consumption of the diacylglycerol oil will lead to persistent and consistent reductions in plasma triacylglycerol and body fat. However future studies may demonstrate a role in managing aspects of the metabolic syndrome.
Tada
Norio
N
Department of General Medicine, Jikei University School of Medicine, Chiba, Japan. n-tada27@jikei.ac.jp
Yoshida
Hiroshi
H
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology; D004075:Diglycerides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood
C011439:1,2-diacylglycerol; D004041:Dietary Fats; D004075:Diglycerides; D008055:Lipids