High-throughput methods for the development of new catalytic asymmetric reactions.
Chiral, single enantiomer pharmaceuticals have become increasingly more important. Therefore, research aimed at providing new methods for their selective preparation has taken on an even greater importance. One of the most efficient strategies for the synthesis of non-racemic, chiral molecules is asymmetric catalysis. There are many variables involved in the discovery of a new catalytic asymmetric transformation; hence, methods for the rapid screening of large numbers of catalysts have been developed. Herein, these techniques and strategies for the rapid discovery of novel asymmetric catalysts are reviewed.
Traverse
John F
JF
Department of Chemistry, Boston College, Eugene F. Merkert Chemistry Center, Room 125, 2609 Beacon Street, Chesnut Hill, MA 02467, USA.
Snapper
Marc L
ML
D000818:Animals; D002384:Catalysis; D020134:Catalytic Domain / Q000502:physiology; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D008968:Molecular Conformation; D013678:Technology, Pharmaceutical / Q000379:methods*