Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia.
T-cell large granular lymphocyte (T-LGL) leukemia is an uncommon disease, with limited information on karyotypic aberrations. No consistent chromosomal changes have thus far been described. We report two cases of T-LGL leukemia who presented with severe anemia. The LGL were CD3+, CD4-, CD8+, CD56-, and CD161-, with variable expression of CD94, CD158a, and CD158b, and had clonal T-cell receptor gene rearrangement. A deletion of the long arm of chromosome 6 was the sole aberration in both cases. This is the first report of a recurrent chromosomal aberration in T-LGL leukemia.
Man
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Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China.
Au
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WY
Pang
A
A
Kwong
Y L
YL
D015703:Antigens, CD / Q000235:genetics; D002051:Burkitt Lymphoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping
D015703:Antigens, CD