Pseudoaneurysm of the iliac artery secondary to Aspergillus infection in two recipients of kidney transplants from the same donor.
The authors report 2 cases of patients who underwent cadaveric renal transplantation from the same donor in a multiorgan extraction procedure. Both cases showed, during the first 6 months posttransplantation, a worsening in renal graft function and signs of ischemia in the homolateral lower limb. One of the cases was preceded by pain in the sciatic region. In imaging tests, a pseudoaneurysm was detected in the iliac artery in both patients. Grafts had to be removed, and the iliac arteries were ligated with posterior isolation of Aspergillus spp from the arterial vessels but not from the renal tissue. Besides surgery, medical treatment with liposomal amphotericin B was initiated with a different outcome in each patient: patient A died, whereas patient B recovered. The absence of Aspergillus spp infection in liver and heart recipients ruled out a donor-transmitted infection. The graft placements were carried out in different operating rooms, which rules out contamination during the transplantation process. All of this leads us to conclude that the infection must have occurred during the preservation phase of the kidney.
Garrido
Jesús
J
Service of Nephrology, University Hospital, Salamanca, Spain.
Lerma
José L
JL
Heras
Manuel
M
Labrador
Pedro J
PJ
García
Pedro
P
Bondía
Antonio
A
Corbacho
Luis
L
Tabernero
José M
JM
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D017541:Aneurysm, False / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy / Q000601:surgery / Q000635:transmission; D002102:Cadaver; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D017543:Iliac Aneurysm / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D007083:Iliac Artery / Q000187:drug effects / Q000382:microbiology / Q000601:surgery / Q000637:transplantation; D007668:Kidney / Q000098:blood supply / Q000382:microbiology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D012077:Renal Artery / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D014019:Tissue Donors
D000935:Antifungal Agents; D000666:Amphotericin B