[Predisposition to multifactorial pathology in residents of the city in the zone around the "Maiak" atomic industry enterprise].
According to present achievements in radiation and molecular genetics it is possible to expect that due to chronic radiation exposure the relative increasing of genetic risk in following generations will be observed. It will be due, in the first place, to increasing a percent of multifactorial diseases (MFD). Most of geneticists refer bronchial asthma (BA) to multifactorial diseases. Genetics and epidemiological analysis of liability to BA in population of Ozyorsk situated in the control area of "Mayak" Production Association (PA "Mayak") was accomplished. Population risk, as probability for an individual in population to develop BA up to the end of life is 2.69%. It's higher than in Moscow (2.03%) (p < 0.05). The excess is due to significantly higher values in females (2.96% against 1.93%). Population risk to fall ill of BA in females of Ozyorsk (2.96%) is significantly higher than in males (2.4%). Prevalence of BA in Ozyorsk (0.60%) is significantly higher than in Moscow (0.47%) due to higher values in females (0.65% against 0.47%). The total risk to fall ill of BA amongst relatives is 5.4% that is twice higher than the population risk. The heritability of BA is 0.71 (in Moscow-0.70).
Vologodskaia
I A
IA
South-Ural Institute of Biophisics, Russian Ministry of Health, Ozyorsk, Chelyabinsk Region, 456780 Russia. Vologodskaya@fib1ko.chel-65.chel.su
Kurbatov
A V
AV
Grigor'eva
E S
ES
D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D011159:Population Surveillance; D011210:Power Plants; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology