title: Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma.
abstract: The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 +/- 30% and 45 +/- 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.
authors.affiliation: Department of Haematology, Toranomon Hospital, Tokyo, Japan. mkami@ncc.go.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kami
authors.forename: Tamae
authors.initials: T
authors.lastname: Hamaki
authors.forename: Shigesaburo
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Naoko
authors.initials: N
authors.lastname: Murashige
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tanosaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takaue
authors.forename: Shuichi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Hisamaru
authors.initials: H
authors.lastname: Hirai
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kasai
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease; D020544:Graft vs Leukemia Effect; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome