title: Diaryloxyacetate herbicides.
abstract: The discovery and investigation of a novel family of herbicides containing a diaryl acetal are described. The stability of the acetal limited herbicidal efficacy and recognizing that fact led to the design of analogs with commercial levels of post-emergence activity on broadleaf weeds. These compounds inhibited acetolactate synthase and in vitro activity data were used to guide target design. However, no members of this family provided a commercially valuable combination of herbicidal efficacy and crop selectivity.
authors.affiliation: Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Smith
authors.forename: William C
authors.initials: WC
authors.lastname: Lo
authors.forename: Wendy
authors.initials: W
authors.lastname: Jacks
authors.forename: Susan
authors.initials: S
authors.lastname: Moore
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Pernich
authors.forename: Mani V
authors.initials: MV
authors.lastname: Subramanian
authors.forename: James A
authors.initials: JA
authors.lastname: Turner
mesh_terms: D000095:Acetolactate Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006540:Herbicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D015394:Molecular Structure; D010944:Plants / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D006540:Herbicides; D000095:Acetolactate Synthase