title: Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks.
abstract: The present study was done to clarify whether intracerebroventricular (ICV) injection of cocaine- and amphetamine-regulated transcript (CART) affects feeding in chicks. ICV injection of CART significantly inhibited fasting-induced feeding of broiler chicks. In layer chicks, on the other hand, CART inhibited food intake in birds with ad libitum access to feed but only weakly affected intake of fasted birds. In addition, the ICV injection of CART attenuated neuropeptide Y (NPY)-induced feeding in both broiler and layer chicks. These results indicate that CART is one of the important regulators of feeding in chicks, but the suppressive effect on feeding is somewhat different between strains. Furthermore, the present study also demonstrates that CART interacts with NPY in the central nervous system to regulate feeding in chicks.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, 812-8581, Fukuoka, Japan. tetsu@brs.kyushu-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
authors.forename: Tomo
authors.initials: T
authors.lastname: Takagi
authors.forename: Shozo
authors.initials: S
authors.lastname: Tomonaga
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohgushi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ando
authors.forename: D Michael
authors.initials: DM
authors.lastname: Denbow
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000367:Age Factors; D000818:Animals; D002645:Chickens / Q000145:classification / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D005215:Fasting / Q000502:physiology; D007276:Injections, Intraventricular / Q000379:methods; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000494:pharmacology; D013997:Time Factors; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein