title: Acetylene sesquiterpenoid esters from the green alga Caulerpa prolifera.
abstract: Sixteen secondary metabolites of the green alga Caulerpa prolifera have been isolated, and their chemical structures elucidated by analysis of their spectroscopic data. Two groups of metabolites have been established, with either a 1,2-dihydro- (2a-2i) or a 1,2,3,3'-tetrahydro-2,3-didehydro (3a-3f) caulerpenyne carbon backbone. The terminal vinyl acetoxy group of caulerpenyne was substituted by various fatty acid residues. The antifouling activity of the algal extract was tested in laboratory assays against two of the major groups of fouling organisms (bacteria, microalgae).
authors.affiliation: School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, University of Athens, Panepistimioupolis Zografou, 157 71 Athens, Greece.
authors.forename: Vangelis
authors.initials: V
authors.lastname: Smyrniotopoulos
authors.forename: Dennis
authors.initials: D
authors.lastname: Abatis
authors.forename: Leto-A
authors.initials: LA
authors.lastname: Tziveleka
authors.forename: Christina
authors.initials: C
authors.lastname: Tsitsimpikou
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
authors.forename: Anargyros
authors.initials: A
authors.lastname: Loukis
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
mesh_terms: D000114:Acetylene / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002734:Chlorophyll / Q000032:analysis; D000460:Chlorophyta / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D017753:Ecosystem; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006115:Greece; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013058:Mass Spectrometry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004952:Esters; D006131:Growth Inhibitors; D012717:Sesquiterpenes; D002734:Chlorophyll; C097889:caulerpenyne; D000114:Acetylene