title: Neurobiologic risk score and long-term developmental outcomes of premature infants, birth weight less than 1,250 grams.
abstract: OBJECTIVE
  To determine whether neurobiologic risk score (NBRS) would continue to correlate with developmental outcomes.
  
  
  METHODS
  An observational cohort consisting of 258 surviving infants who returned to the follow-up clinic with a mean age 22 months' corrected age. Both univariate and multivariate analysis were performed to identify risk factors and to assess the predictive value of NBRS.
  
  
  RESULTS
  Forty-eight to 53 per cent of these infants had growth parameters < 25th percentile for age. Seventeen and 18 per cent respectively had mental developmental index (MDI) and psychomotor developmental index (PDI) on the Bayley Scales less than 70 and 14 per cent developed cerebral palsy (CP). NBRS demonstrated a significant correlation with the outcome (p < 0.001). In infants with NBRS > or = 8, 48 per cent had MDI < 70 and 68 per cent, had PDI < 70. At a similar NBRS cutoff, specificity and negative predictive value (NPV) were 86 and 96 per cent, respectively. Logistic regression indicated that birth weight and gestational age were the most significant, independent variables for predicting poor outcomes.
  
  
  CONCLUSIONS
  Very preterm infants in the present study were at risk for abnormal developmental outcomes. NBRS demonstrated a very high specificity and NPV and may be a useful index to identify those who need early intervention.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Pracha
authors.initials: P
authors.lastname: Nuntnarumit
authors.forename: Henrietta S
authors.initials: HS
authors.lastname: Bada
authors.forename: Sheldon B
authors.initials: SB
authors.lastname: Korones
authors.forename: Wenjian
authors.initials: W
authors.lastname: Yang
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D009422:Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D018570:Risk Assessment; D013997:Time Factors