Slug expression during organogenesis in mice.
The vertebrate Slug gene encodes a zinc finger-containing transcriptional repressor. Here we report expression of the mouse Slug gene during organogenesis and late fetal development using histochemical detection of beta-galactosidase expressed from a targeted Slug(lacZ) knock-in allele. The Slug gene is highly expressed in the mesenchymal or stromal component of numerous organs. It is also highly expressed in craniofacial mesenchyme, in bone of both mesodermal and neural crest origin, and in the outflow tract and the endocardial cushions of the heart.
Oram
Kathleen F
KF
Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Carver
Ethan A
EA
Gridley
Thomas
T
D000818:Animals; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism; D003433:Crosses, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D038081:Organogenesis; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics*
C000604449:Snai2 protein, mouse; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors