[Analysis of psychotropic drug mixtures using high-pressure liquid chromatography in acute poisoning cases].
The qualitative and quantitative method of determination of amitryptilin, codeine and fluoxetine in the mixture using high-pressure liquid chromatography is described in this paper. Chromatogram is presented which shows, that preparations are fully separated and do not interfere each others analysis. Tables with chromatographical separation characteristics are also presented. Proposed calibration curves of quantitative analysis and calculated medium relative error of quantitative ascertainment for every preparation of the mixture are shown. Final conclusion: method is applicable for qualitative and quantitative analysis of amitryptiline, fluoxetine and codeine in the mixture in hasty poisoning cases.
Kazlauskiene
Daiva
D
Kauno medicinos universiteto Analizines ir toksikologines chemijos katedra, Mickeviciaus 9, 3000 Kaunas. daivakazlauskiene@centras.lt
Vainauskas
Paulius
P
Kazlauskas
Saulius
S
D000208:Acute Disease; D000639:Amitriptyline / Q000032:analysis / Q000506:poisoning; D000701:Analgesics, Opioid / Q000032:analysis / Q000506:poisoning; D018687:Antidepressive Agents, Second-Generation / Q000032:analysis / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003061:Codeine / Q000032:analysis / Q000506:poisoning; D005473:Fluoxetine / Q000032:analysis / Q000506:poisoning; D006801:Humans; D011619:Psychotropic Drugs / Q000032:analysis* / Q000506:poisoning*
D000701:Analgesics, Opioid; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D011619:Psychotropic Drugs; D005473:Fluoxetine; D000639:Amitriptyline; D003061:Codeine