title: A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature.
abstract: Osteosarcoma arising in soft tissues is exceedingly rare in children. The tumor most often affects older adults, involves the lower extremity, responds poorly to chemotherapy, and carries a grave prognosis. The authors describe a 12-year-old girl with an extraosseous osteosarcoma of the left sternocleidomastoid muscle with pulmonary metastases. The patient responded well to neoadjuvant chemotherapy and remains disease-free nearly 3 years after her initial diagnosis. The authors review available information about this disease in children and adults. Children with extraosseous osteosarcoma may have a more favorable response to treatment than adults; thus, a curative approach using combined modality therapy appears warranted.
authors.affiliation: Departments of Hematology/ Oncology, St. Jude's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Wodowski
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Alberto S
authors.initials: AS
authors.lastname: Pappo
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Shochat
authors.forename: Larry E
authors.initials: LE
authors.lastname: Kun
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Spunt
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D020360:Neoadjuvant Therapy; D012516:Osteosarcoma / Q000188:drug therapy* / Q000556:secondary; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D007069:Ifosfamide