Clues to the genetic influences of drug responsiveness in epilepsy.
Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug-metabolizing enzymes, and ion channels. We review the literature and speculate the contribution of each of these factors in management of patients with epilepsy in the future.
Ramachandran
V
V
National Neuroscience Institute, Singapore.
Shorvon
Simon D
SD
D000927:Anticonvulsants / Q000627:therapeutic use*; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans
D000927:Anticonvulsants