Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma.
Diagnosis of a second HIV-associated non-Hodgkin lymphoma (HIV-NHL) is rare, but additional cases may occur as aggressive therapy for both HIV and NHL improves. An 11-year-old presented with a second primary HIV-NHL following remission for 9 years. Analysis of the tumor demonstrated presence of EBV and HIV with absence of CMV, HHV-8, and HHV-6. Although microscopic disease was present only in CSF, analysis of peripheral blood and bone marrow by PCR was positive. The patient underwent a stem cell transplant, but within 3 months, his disease recurred. Analysis for residual disease and viruses in similar cases may provide information in understanding pediatric HIV-NHL.
Cabalo
Eve
E
University of Alberta School of Medicine, Edmonton, Canada.
Wilkinson
Robert
R
Lu
Nu T
NT
Shimizu
Sheri
S
Melish
Marian
M
McClain
Kenneth L
KL
Jenson
Hal B
HB
Shiramizu
Bruce
B
D019380:Anti-HIV Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology* / Q000821:virology; D002648:Child; D006678:HIV / Q000378:metabolism; D015658:HIV Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D016483:Lymphoma, AIDS-Related / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
D019380:Anti-HIV Agents