Cellular cardiomyoplasty: cell therapy for myocardial regeneration.
Cellular cardiomyoplasty (cell therapy for myocardial regeneration) targets the basic pathophysiology of heart failure, the irreversible loss of functional cardiomyocytes, and represents a novel means of augmenting cardiomyocyte number and contractile function of the failing heart. We discuss briefly the concept of myocardial regeneration and explore various cell types that may act as potential sources for myocardial tissue engineering.
Chedrawy
Edgar G
EG
Division of Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada.
Chiu
Ray C J
RC
D000818:Animals; D018421:Cardiomyoplasty / Q000379:methods*; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*