[Study of protective effect of perftoran on a skin flaps].
Differences in the levels of tissue respiration in the rat skin flaps incubated in perfluothane (PF) and normal saline (NS) are regarded as an evidence of local PF effect on tissue substrate. The complex of metabolic changes in the skin fragments under the effect of PF in comparison with skin fragments incubated in NS indicate a protective effect of PF on tissue substrata. Decreased content of malonic dialdehyde and a slower accumulation of tissue liquid in skin flaps incubated in PF, in comparison with the fragments incubated in NS, is worthy of note. It indicates that incubation in PF (in comparison with incubation in NS) is less harmful for cell membranes and induces lesser disorders in water-salt metabolism and edema which are usually associated with tissue lesions developing under conditions of trophic deficiency.
Zhitkov
M Iu
MIu
Orlov
A A
AA
Grigor'ian
A S
AS
Ippolitov
V P
VP
Chupakhin
P V
PV
D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D019069:Cell Respiration / Q000187:drug effects / Q000502:physiology; D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology; D005466:Fluorocarbons / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D013524:Surgical Flaps / Q000502:physiology; D014021:Tissue Preservation / Q000379:methods
D001802:Blood Substitutes; D005466:Fluorocarbons; C063334:perftoran