Occult orbital neuroblastoma detected after administration of an antitumor vaccine.
A 6-year-old girl with neuroblastoma developed swelling and erythema of her right upper eyelid following administration of an interleukin-2 and lymphotactin gene-modified allogeneic neuroblastoma cell vaccine. Computed tomography demonstrated a cystic lesion in the subperiosteal space. A biopsy of the mass showed necrotic neuroblastoma with minimal associated inflammation. To our knowledge, this case represents the first description of occult orbital metastases in a patient with neuroblastoma detected after administration of an antitumor vaccine.
Wilson
Matthew W
MW
Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Moshfeghi
Darius M
DM
Haik
Barrett G
BG
Haight
Ann E
AE
Hill
D Ashley
DA
Davidoff
Andrew M
AM
Rousseau
Raphael F
RF
Bowman
Laura C
LC
D019496:Cancer Vaccines / Q000008:administration & dosage*; D002481:Cellulitis / Q000175:diagnosis / Q000209:etiology; D019744:Chemokines, C; D002648:Child; D005094:Exophthalmos / Q000175:diagnosis / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D012795:Sialoglycoproteins / Q000276:immunology*; D014057:Tomography, X-Ray Computed; D014611:Vaccination
D019496:Cancer Vaccines; D019744:Chemokines, C; D007376:Interleukin-2; D008222:Lymphokines; D012795:Sialoglycoproteins; C092390:XCL1 protein, human; C018997:lymphotactin