Hepatoprotective and antihyperliposis activities of in vitro cultured Anoectochilus formosanus.
The pharmacological effects of an aqueous extract of the whole plants of in vitro cultured Anoectochilus formosanus were investigated experimentally for hepatoprotective and antihyperliposis activities. The extract showed significant antihepatotoxic activity against carbon tetrachloride induced cytotoxicity in primary cultured rat hepatocytes. In an assay for antihyperliposis using aurothioglucose-induced obese mice, the extract suppressed significantly the increase in the weights of body and liver, ameliorated triglyceride levels in the liver and serum, and also significantly reduced the deposition of adipose tissue.
Du
Xiao-Ming
XM
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582 , Japan.
Sun
Ning-Yi
NY
Hayashi
Jun
J
Chen
Yang
Y
Sugiura
Minoru
M
Shoyama
Yukihiro
Y
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006051:Aurothioglucose; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D022781:Hepatocytes / Q000187:drug effects; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029595:Orchidaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
D000975:Antioxidants; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D006051:Aurothioglucose; D002251:Carbon Tetrachloride