title: Familial vocal fold paralysis.
abstract: Familial clustering of congenital bilateral abductor vocal fold paralysis has been reported very rarely. So far, only a handful of cases have been reported, mostly with the autosomal dominant of X-linked recessive mode of inheritance. We describe the cases of a brother and sister, who presented with neonatal stridor due to bilateral abductor vocal fold paralysis. First-degree parental consanguinity suggests an autosomal recessive mode of inheritance. Karyotype analysis revealed a paracentric balanced inversion of chromosome 13 in both cases, that was also present in the unaffected mother. An updated review of the literature on this interesting but rare condition is also presented.
authors.affiliation: Department of Otolaryngology, University Hospital of Wales, Cardiff, UK. syedaliraza63@hotmail.com
authors.forename: S Ali
authors.initials: SA
authors.lastname: Raza
authors.forename: S
authors.initials: S
authors.lastname: Mahendran
authors.forename: Nazneen
authors.initials: N
authors.lastname: Rahman
authors.forename: R G
authors.initials: RG
authors.lastname: Williams
mesh_terms: D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping / Q000379:methods; D008297:Male; D014826:Vocal Cord Paralysis / Q000235:genetics*