title: [Application of Ca(2+)-ISME in the studies on pharmacokinetics of calcium supplements].
abstract: OBJECTIVE
  To determined the concentration of Ca2+ in serum by a self-made Ca(2+)-ISME in order to indicate the absorption of calcium supplement.
  
  
  METHODS
  We have developed a calibration curve method to measure Ca2+ activities in serum sample. The pharmacokinetics of three kinds of calcium supplements were investigated by the Ca(2+)-ISME after P.O. administration in 5 healthy rats.
  
  
  RESULTS
  Though the Tmax (hours) of the three kinds of preparations were different, there were no significant differences among their AUC by paired t-text.
  
  
  CONCLUSIONS
  The above results demonstrate that our self-made Ca(2+)-ISME is applicable to the researches on pharmacokinetics of calcium supplements.
authors.affiliation: School of Pharmaccology, WCUMS, Chengdu 610041, China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: T
authors.initials: T
authors.lastname: Lü
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood / Q000493:pharmacokinetics*; D019587:Dietary Supplements; D005260:Female; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002118:Calcium