Stimuli sensitive polymethacrylic acid microparticles (PMAA)--oral insulin delivery.
This study investigated polymethacrylic acid (PMAA) microparticles for controlled release of Insulin in oral administration. The microparticles were characterised by scanning electron microscopy (SEM) for morphological studies. The swelling behaviour and drug release profile in various pH media were studied. The % swelling of gels was found to be inversely related to the amount of crosslinker added. Inclusion complex of betaCD and Insulin was studied using polyacrylamide gel electrophoresis (PAGE). Optimum complexation was obtained in the ratio 100 mg betaCD: 200 IU Insulin. The release pattern of Insulin from Insulin-betaCD complex encapsulated PMAA microparticles showed release of Insulin for more than seven hours.
Victor
Sunita Prem
SP
Biosurface Technology Division, BMT Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum 695 012, India.
Sharma
Chandra P
CP
D000284:Administration, Oral; D003505:Cyclodextrins / Q000737:chemistry; D004337:Drug Carriers; D004591:Electrophoresis, Polyacrylamide Gel; D066298:In Vitro Techniques; D007328:Insulin / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011109:Polymethacrylic Acids; D013499:Surface Properties; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004337:Drug Carriers; D007328:Insulin; D011109:Polymethacrylic Acids; D047392:beta-Cyclodextrins; C030613:polymethacrylic acid; C031215:betadex