[Prevalence of anti-GAD autoantibodies in Tunisian children with type 1 diabetes].
The prevalence of GAD antibodies and its correlation with some autoimmune markers: ICA (islet cells antibodies), antinuclear antibodies, thyroid antithymune and antimicrosomes antibodies, were studied in 84 Tunisian type 1 diabetic children. The prevalence of GAD antibodies was 51.2% and decreased as a function of increasing duration of the disease. Their frequency was 84.6% in children with newly diagnosed diabetes (within 6 months of diagnosis) and only 29.41% in those with a longer duration of the diabetes (more than 5 years). ICA were present less frequently (21.4% of the children). 10.7% of the studied samples were positive with the two antibodies (GAD ab ICA), and 40% were positive only with GAD antibodies. We conclude that the GAD antibodies seems to be more associated to the development of type 1 diabetes than ICA. They are detected more frequently in patients with long standing disease, that's make their determination very interesting as diagnostic and predictive marker.
Elkadhi
Amina
A
Institut National de Nutrition et de Technologie Alimentaire, Tunis, Tunisie.
Khelifi
Nejib
N
Abid
Abdelmagid
A
Nagati
Khemais
K
Jenhani
Faouzi
F
Ben Rayana
Mohamed Chiheb
MC
D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007453:Iodide Peroxidase; D033862:Iron-Binding Proteins; D011237:Predictive Value of Tests; D016036:Seroepidemiologic Studies; D013997:Time Factors; D014416:Tunisia / Q000453:epidemiology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D033862:Iron-Binding Proteins; C024211:islet cell antibody; C056658:TPO protein, human; D007453:Iodide Peroxidase; D005968:Glutamate Decarboxylase