title: Magnetic resonance imaging and neurosphere therapy of stroke in rat.
abstract: We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of transplanted cells was non-invasively tracked using magnetic resonance imaging (MRI). We found that transplanted cells selectively migrated towards the ischemic parenchyma at a mean speed of 65 +/- 14.6 microm/hr in living rats. Migration of transplanted cells in the brain was also measured histopathologically. Rats transplanted with SVZ cells exhibited significant improvement of neurological function. Our data suggest that intracisternal transplantation of SVZ cells provides an avenue for cell therapy of stroke and that MRI can be used to track grafted cells in the brain.
authors.affiliation: Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA.
authors.forename: Zheng Gang
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Quan
authors.initials: Q
authors.lastname: Jiang
authors.forename: Ruilan
authors.initials: R
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Lijei
authors.initials: L
authors.lastname: Zhang
authors.forename: Polly
authors.initials: P
authors.lastname: Arniego
authors.forename: Khang-Loon
authors.initials: KL
authors.lastname: Ho
authors.forename: Michael
authors.initials: M
authors.lastname: Chopp
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000601:surgery; D002465:Cell Movement; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D020521:Stroke / Q000473:pathology* / Q000601:surgery*