[Pharmacological cardioversion of atrial fibrillation with intravenous and oral propafenone].
The aim of the study was to evaluate the efficacy of intravenous and oral propafenone for termination of recent onset (<48 hrs) atrial fibrillation. Forty-seven nonvalvular patients with atrial fibrillation were included in the study. Sinus rhythm was restored in 19/31 (61.3%) patients after intravenous treatment: in 15/31 (48.4%) atrial fibrillation was stopped after bolus of propafenone in dose of 2 mg/kg body weight, in 4/16 (25.0%) - by followed infusion of medicine in dose of 0.008 mg/kg/min during 2 hrs. A single 600 mg oral dose of propafenone restored sinus rhythm in 9/16 (56.2%) patients during 4 hrs. Transformation of atrial fibrillation into regular atrial flutter was observed in 4 cases; in 1 of them right bundle branch block developed.
Peciuliene
Irena
I
Institute of Cardiology, Kaunas University of Medicine, Sukileliu 17, 3007 Kaunas, Lithuania. aritmiki@kmu.lt
Lukoseviciūte
Aldona
A
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D011405:Propafenone