title: Immune complex-associated thrombocytopenic purpura syndrome in sexually mature Göttingen minipigs.
abstract: Eleven cases of thrombocytopenic purpura (TP) in sexually mature male or female Göttingen minipigs occurred sporadically over 3 1/2 years in a closed breeding colony protected by strict barrier conditions. Typical clinical signs of TP, including extensive subcutaneous haemorrhages, were seen in all affected animals. Haematological abnormalities included marked thrombocytopenia and anaemia. A consistent histopathological finding was the presence of membranoproliferative lesions in the renal glomeruli. Immunohistochemically, glomerular deposits were positively labelled for complement factor C1q and often also for immunoglobulins. Bone marrow findings consisting of increased numbers of immature and apoptotic megakaryocytes were compatible with a state of increased platelet consumption. Based on the combined presence of thrombocytopenia and renal immune complexes, it is suggested that the syndrome was related to a type III hypersensitivity reaction. However, further studies are needed to verify this hypothesis.
authors.affiliation: Departamento de Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Facultad de Veterinaria, Universidad de Córdoba, Campus Universitario de Rabanales, 14014 Córdoba, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
authors.forename: L W
authors.initials: LW
authors.lastname: Madsen
authors.forename: F J
authors.initials: FJ
authors.lastname: Salguero
authors.forename: A
authors.initials: A
authors.lastname: Núñez
authors.forename: P
authors.initials: P
authors.lastname: Sánchez-Cordón
authors.forename: P
authors.initials: P
authors.lastname: Bollen
mesh_terms: D000740:Anemia / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D002452:Cell Count / Q000662:veterinary; D015922:Complement C1q / Q000032:analysis; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000473:pathology / Q000662:veterinary; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D007105:Immune Complex Diseases / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D011696:Purpura, Thrombocytopenic / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D012741:Sexual Maturation; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000473:pathology*; D013556:Swine, Miniature / Q000276:immunology*; D013577:Syndrome
chemical_list: D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D015922:Complement C1q