Photoprotective activity of melanin preparations in human skin exposed to UV irradiation: dependence on previous photoexposure.
Photoprotective effects of three melanin preparations (from black yeast fungi and Sepia sp.) were studied. These preparations in aqueous solutions (5 g/ml, dark exposure for 7 days) demonstrated high photomodification capacity upon exposure to visible light in doses of up to 1.8 kJ/m2. Preliminary exposure of these solutions to visible light in a dose of 360 kJ/m2 notably decreased the photoprotective effect of melanins during UV exposure of the skin treated with these solutions (at UV dose of 3.4 kJ/m2). This necessitates empirical selection of the dose and storage condition of melanin preparations for attaining the optimal photoprotective effect.
Paramonov
B A
BA
SPb-Tekhnologiya Firm, St. Petersburg.
Turkovskii
I I
II
Potokin
I L
IL
Yurlova
N A
NA
Chebotarev
V Yu
VY
D001203:Ascomycota / Q000737:chemistry; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008543:Melanins / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors; D014466:Ultraviolet Rays
D008543:Melanins; D011837:Radiation-Protective Agents