Stereoselective synthesis of enynes by nickel-catalyzed cross-coupling of divinylic chalcogenides with alkynes.
(Z,Z)- and (E,E)-divinylic selenides and telurides undergo direct coupling with terminal alkynes in the presence of a nickel/CuI catalyst at room temperature to give (Z)- and (E)-enyne systems in good yields and with complete retention of configuration.
Silveira
Claudio C
CC
Departamento de Química, Universidade Federal de Santa Maria, C. P. 5001, CEP 97105-900, RS, Brazil. silveira@quimica.ufsm.br
Braga
Antonio L
AL
Vieira
Adriano S
AS
Zeni
Gilson
G