title: Challenging but essential targets for genuine anti-ageing drugs.
abstract: Contrary to what one might conclude from the popular press, anti-ageing drugs do not yet exist, in the sense in which the term 'drug' is normally used. Since a drug is assumed to be effective against its target human pathology and since the vast majority of deaths in the developed world are from ageing-related causes, it is inappropriate to describe something as an anti-ageing drug unless one has good reason to believe that it will appreciably extend the life expectancy of those in the developed world who receive it. A drug that rejuvenates aspects of the aged body but does not increase life expectancy is an antifrailty drug, not an anti-ageing one. This distinction is critical for decision makers in the drug discovery sphere because, while the market for antifrailty drugs (even unproven ones) is large, that for genuine anti-ageing drugs - which, as the author explains, are now foreseeable - will certainly be far larger. In this article, the author surveys the main aspects of age-related degeneration that are believed to be essential targets for genuine anti-ageing drugs - that is, without whose amelioration human life expectancy probably cannot be greatly increased - and some promising strategies for the design of such drugs.
authors.forename: Aubrey D N J
authors.initials: AD
authors.lastname: De Grey
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D016922:Cellular Senescence / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics; D015195:Drug Design; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000187:drug effects; D017127:Glycation End Products, Advanced; D006801:Humans; D008247:Lysosomes / Q000187:drug effects; D046911:Macromolecular Substances; D008928:Mitochondria / Q000187:drug effects
chemical_list: D004272:DNA, Mitochondrial; D016326:Extracellular Matrix Proteins; D017127:Glycation End Products, Advanced; D046911:Macromolecular Substances