title: Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication.
abstract: Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIV(mac)239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.
authors.affiliation: Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715-1299, USA.
authors.forename: Bianca R
authors.initials: BR
authors.lastname: Mothé
authors.forename: Jason
authors.initials: J
authors.lastname: Weinfurter
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wang
authors.forename: William
authors.initials: W
authors.lastname: Rehrauer
authors.forename: Nancy
authors.initials: N
authors.lastname: Wilson
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
authors.forename: David B
authors.initials: DB
authors.lastname: Allison
authors.forename: David I
authors.initials: DI
authors.lastname: Watkins
mesh_terms: D000483:Alleles; D000818:Animals; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008253:Macaca mulatta; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D019562:Viral Load; D014779:Virus Replication / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; C110764:Mamu-A 01 antigen; D012367:RNA, Viral