title: A simple synthesis of 7,4'-dihydroxy-6-methoxyisoflavone, glycitein, the third soybean isoflavone.
abstract: 4-Methoxyresorcinol (3) was synthesized as the precursor for glycitein (6) synthesis by the oxidation of 3-hydroxy-4-methoxybenzaldehyde (1) to the aryl formate with H2O2 and a catalytic amount of SeO2. Glycitein (6) was synthesized by cyclization of 2,4,4'-trihydroxy-5-methoxydeoxybenzoin (5) with N,N-dimethylformamide, boron trifluoride diethyl ether, and methanesulfonyl chloride in a microwave oven.
authors.affiliation: Department of Chemistry, Kenyatta University, Nairobi, Kenya.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lang'at-Thoruwa
authors.forename: Tong T
authors.initials: TT
authors.lastname: Song
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.forename: Andrean L
authors.initials: AL
authors.lastname: Simons
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Murphy
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007529:Isoflavones / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010946:Plants, Medicinal / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry; D018036:Selenium Compounds; D064588:Selenium Oxides; D013025:Glycine max / Q000737:chemistry*
chemical_list: C474533:4-methoxyresorcinol; D007529:Isoflavones; D012118:Resorcinols; D018036:Selenium Compounds; D064588:Selenium Oxides; C086566:glycitein