Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation.
The antiinflammatory activity of an alcohol extract of Achyranthes aspera was tested on carrageenin-induced hind paw oedema and cotton pellet granuloma models in albino male rats. The paw volume was measured plethysmometrically at 0, 1, 2, 3, 4 and 5 h. In the subacute model cotton pellet granuloma was produced by implantation of 50 +/- 1 mg sterile cotton in the axilla under ether anaesthesia. The animals were fed with an alcohol extract at various dose levels (125, 250, 375 and 500 mg/kg). Diclofenac sodium was used as a standard drug. The alcohol extract (375 and 500 mg/kg) showed the maximum inhibition of oedema of 65.38% and 72.37% at the end of 3 h with carrageenin-induced rat paw oedema, respectively. Using a chronic test, the extract exhibited a 40.03% and 45.32% reduction in granuloma weight.
Vetrichelvan
T
T
Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, Tamil Nadu, India. vetrisel@yahoo.com
Jegadeesan
M
M
D029044:Achyranthes; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012720:Severity of Illness Index
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D004008:Diclofenac; D002351:Carrageenan