title: Glucose regulation and oxidative stress in healthy centenarians.
abstract: Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
authors.affiliation: Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, IV Divisione di Medicina Interna, Piazza Miraglia 2, I-80138 Napoli, Italy.
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Rizzo
authors.forename: Daniela
authors.initials: D
authors.lastname: Manzella
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Grella
authors.forename: Emilia
authors.initials: E
authors.lastname: Ragno
authors.forename: Marco
authors.initials: M
authors.lastname: Carbonella
authors.forename: Angela Marie
authors.initials: AM
authors.lastname: Abbatecola
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005838:Genotype; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance; D008136:Longevity; D018384:Oxidative Stress; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
chemical_list: D007328:Insulin; D014446:Tyrosine 3-Monooxygenase; D005947:Glucose