Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hyperpyrexia.
Serum cytokine profiles in patients with Plasmodium vivax malaria who presented with and without hyperpyrexia were compared by a retrospective review of the medical records of the consecutive patients seen at the military hospitals near the demilitarized zone in the Republic of Korea from April 2000 through October 2001. Of 162 male patients studied, 120 (86.4%) presented with hyperpyrexia (i.e., an axillary temperature > or = 40 degrees C). The mean +/- SEM ages of the patients with and without hyperpyrexia were 21.5 +/- 0.14 and 21.9 +/- 0.39 years, respectively (P = 0.33). The mean +/- SEM concentrations of serum interleukin (IL)-6 (379.7 +/- 44.1 pg/mL versus 105.4 +/- 26.8 pg/mL; P = 0.002), IL-10 (583.4 +/- 58.2 pg/mL versus 142.4 +/- 39.7 pg/mL; P = 0.0001), and interferon-gamma (312.6 +/- 33.9 pg/mL versus 112.9 +/- 27.1 pg/mL; P = 0.0001) were significantly higher in patients with hyperpyrexia compared with those without hyperpyrexia. The mean +/- SEM concentrations of serum tumor necrosis factor-alpha were 155.5 +/- 54.5 pg/mL and 109.9 +/- 29.3 pg/mL (P = 0.27) in patients who presented with and without hyperpyrexia, respectively. Further studies are needed to examine whether serum concentrations of these cytokines also parallel their concentrations at the tissue sites of their production and action.
Seoh
Ju-Young
JY
Department of Microbiology, Parasitology, Preventive Medicine, Internal Medicine, and Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
Khan
Mohammad
M
Park
Se-Ho
SH
Park
Hae-Kyung
HK
Shin
Myong-Heon
MH
Ha
Eun-Hee
EH
Lee
Bo-Eun
BE
Yoo
Kwon
K
Han
Ho-Seong
HS
Oh
Sejoong
S
Wi
Jun-Hwan
JH
Hong
Chang-Kwon
CK
Oh
Chang-Hyun
CH
Kim
Young-A
YA
Park
Jae-Won
JW
D000328:Adult; D016207:Cytokines / Q000097:blood*; D005334:Fever / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007723:Korea; D016780:Malaria, Vivax / Q000150:complications / Q000276:immunology*; D008889:Military Personnel; D012189:Retrospective Studies
D016207:Cytokines