title: Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis.
abstract: Transplant patients suffering from hepatocellular carcinoma in cirrhosis are selected according to tumor nodule number and diameter. Vascular invasion and histopathological grading are predictive of outcome. The prognostic influence of hepatitis B-cirrhosis has been investigated after resection and after local tumor treatment, but not after transplantation. Of the 1,188 transplantations performed between 1989 and 2000, 120 were on patients with hepatocellular carcinoma in cirrhosis (HCC) (follow-up: 57 months; 1-140 months). Within this group, 25 patients (21%) suffered from hepatitis B. Pre-transplant selection criteria were a maximum diameter of 5 degrees cm in uni-nodular tumors, or 3 degrees cm for two to three tumor nodules. The rate of tumors with 2-3 tumor nodules was increased in the hepatitis-B group (52% vs. 29%; P<0.05). Other tumor characteristics did not differ. In the hepatitis-B group, more patients died post-transplantation (44% vs.22%; P<0.05). This difference was due to unspecific causes, not to tumor recurrence or re-infection. These findings may be indicative of a more complicated course in patients suffering from hepatitis B in general.
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, Charité Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. sven.jonas@charite.de
authors.forename: Sven
authors.initials: S
authors.lastname: Jonas
authors.forename: Thomas
authors.initials: T
authors.lastname: Steinmüller
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Tullius
authors.forename: Armin
authors.initials: A
authors.lastname: Thelen
authors.forename: Utz
authors.initials: U
authors.lastname: Settmacher
authors.forename: Thomas
authors.initials: T
authors.lastname: Berg
authors.forename: Cornelia
authors.initials: C
authors.lastname: Radtke
authors.forename: Peter
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D005260:Female; D006509:Hepatitis B / Q000401:mortality*; D006801:Humans; D008103:Liver Cirrhosis / Q000401:mortality / Q000821:virology; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality