[New perspectives in the treatment of hypertension].
Very interesting results of several long-term studies concerning the treatment of hypertension were recently presented at the 18th "Journées de l'Hypertension" conference. Two of them are particularly interesting as, to our knowledge, they are the first studies designed to evaluate the use of fixed very low dose ACE inhibitor/diuretic bitherapy as first-line treatment for systolodiastolic hypertension and isolated systolic hypertension, over a long follow-up period. Both studies included hypertensive patients over the age of 65, and the only option left to the investigators was to adapt the dosage in the case of insufficient blood pressure control (suspine DBP > 90 mmHg). In particular, the results in the overall population show that 80% of patients "controlled" at 3 months, subsequently remained controlled throughout the study period (total of 15 months). The results obtained in isolated systolic hypertension were of the same order of magnitude. The results observed with this fixed very low dose ACE inhibitor/diuretic bitherapy appear very promising in terms of compliance with treatment and long-term blood pressure control, compared to those obtained with any other antihypertensive drugs indicated as first-line treatment of hypertension.
Mourad
J J
JJ
Service de Médecine Interne, Hôpital Saint Michel, 33 rue Olivier de Serres, 75015 Paris.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013599:Systole / Q000187:drug effects; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics