title: [Biological characters of adenoid cystic carcinoma cells transduced with HSV-tk gene].
abstract: OBJECTIVE
  To study the effects of herpes simplex virus thymidine kinase(HSV-tk) gene transduction on adenoid cystic carcinoma(ACC) cells.
  
  
  METHODS
  Gene transduced cells were detected with growth rate, scanning electronic microscope, transmission electronic microscope, cell cycle analysis and the expression of major histocompatibility complex(MHC) class I or II molecules.
  
  
  RESULTS
  The parameters detected in gene transduced cells and parental tumor cells were similar.
  
  
  CONCLUSIONS
  The HSV-tk gene transduction would not change the biological characters of tumor cells greatly.
authors.affiliation: Tumor Biology Laboratory, Department of Oral & Maxillofacial Surgery, Ninth Hospital, Shanghai Second Medical University.
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.forename: R
authors.initials: R
authors.lastname: He
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: S
authors.initials: S
authors.lastname: Chen
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000276:immunology / Q000473:pathology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D012468:Salivary Gland Neoplasms / Q000276:immunology / Q000473:pathology*; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics*; D013937:Thymidine Kinase / Q000235:genetics*; D014161:Transduction, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D013937:Thymidine Kinase