title: A case of primary cutaneous histoplasmosis in a patient with diabetes and multi-infarct dementia.
abstract: We report a case of primary cutaneous histoplasmosis in a fifty-year-old African-American woman with diabetes and multi-infarct dementia. The patient developed fever and crusted, nodulo-ulcerative lesions of the skin after accidental superficial trauma to the forehead. The biopsy revealed suppurative granulomatous inflammation with intracellular and extracellular yeast-like cells with associated clear halo measuring 3-4 mm in size. Systemic involvement was not found. The lesions cleared after treatment with itraconazole 200 mg twice a day for 3 weeks. The medication was continued for a total period of 3 months, with no signs of recurrence after one-year of follow-up.
authors.affiliation: Section of Dermatology, University of Chicago, Chicago, Illinois, USA.
authors.forename: Aleksandar L
authors.initials: AL
authors.lastname: Krunic
authors.forename: Henry
authors.initials: H
authors.lastname: Carag
authors.forename: Maria M
authors.initials: MM
authors.lastname: Medenica
authors.forename: Allan L
authors.initials: AL
authors.lastname: Lorincz
mesh_terms: D001707:Biopsy, Needle; D015161:Dementia, Multi-Infarct / Q000150:complications / Q000175:diagnosis*; D003881:Dermatomycoses / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D017964:Itraconazole / Q000008:administration & dosage; D008875:Middle Aged; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D017964:Itraconazole