Clonal rearrangement of 15p11.2, 16p11.2, and 16p13.3 in a case of nodular fasciitis: additional evidence favoring nodular fasciitis as a benign neoplasm and not a reactive tumefaction.
This article describes a case of nodular fasciitis with the karyotype 47,XY,+4/46,XY,add(15)(p11.2), t(16;16)(p13.3;p11.2). The presence of clonal chromosomal abnormalities in this case, as well as in three previously reported cases, indicates that nodular fasciitis is a benign neoplasm and not a reactive lesion.
Donner
L R
LR
Department of Pathology, Scott & White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, The Texas A&M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA. ldonner@swmail.sw.org
Silva
T
T
Dobin
S M
SM
D002471:Cell Transformation, Neoplastic; D002871:Chromosome Banding; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure; D002999:Clone Cells / Q000648:ultrastructure; D005208:Fasciitis / Q000145:classification / Q000235:genetics / Q000473:pathology*; D005347:Fibroblasts / Q000648:ultrastructure*; D006230:Hand Injuries / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D014945:Wound Healing