Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.
[reaction: see text] The Rh-TangPhos catalyst has been used for asymmetric hydrogenation of itaconic acid and enol acetate derivatives. A variety of chiral 2-substituted succinic acids and chiral acetates have been obtained in excellent ee values (up to 99% ee).
Tang
Wenjun
W
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Liu
Duan
D
Zhang
Xumu
X
D000085:Acetates / Q000138:chemical synthesis; D002384:Catalysis; D006865:Hydrogenation; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry
D000085:Acetates; D013386:Succinates; D012238:Rhodium; C005229:itaconic acid