Sensing stretch is fundamental.
Stretch induces changes in cardiomyocyte biology that are implicated in heart failure, but the mechanism by which stretch is sensed and signals are transduced is unknown. New understanding of the Z disc elements of contractile units are beginning to elucidate the mechanism of stretch sensing and its relation to cardiac adaptation and disease.
Epstein
Neal D
ND
Molecular Physiology Section, Laboratory of Molecular Cardiology, NHLBI, NIH, Bethesda, MD 20892, USA. nepstein@helix.nih.gov
Davis
Julien S
JS
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003285:Contractile Proteins / Q000378:metabolism; D005246:Feedback; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism
D003285:Contractile Proteins