title: Effects of 3 days of "postoperative" low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects.
abstract: OBJECTIVE
  Insulin resistance after surgery is caused by the surgical trauma and presumably also by other factors, such as starvation and immobilization. The purpose of this study was to evaluate the effect of traditional postsurgical low caloric feeding and bed rest on insulin sensitivity and substrate utilization, in younger and older healthy subjects.
  
  
  METHODS
  Twelve healthy subjects underwent hyperinsulinaemic, normoglucaemic clamps and indirect calorimetry before and after 3 days of bed rest and low caloric feeding. Six of the subjects underwent a second study with 3 days of low caloric feeding without bed rest.
  
  
  RESULTS
  Insulin sensitivity decreased by 57+/-16 % after low caloric feeding combined with bed rest, with no difference between age groups, and by 56+/-9% after low caloric feeding only. Glucose oxidation decreased, while fat oxidation increased. No significant differences were seen between age groups or between the protocols.
  
  
  CONCLUSIONS
  Low caloric feeding, a commonly used nutritional routine in clinical practice, induce marked alterations in insulin sensitivity and substrate utilization. Increasing age or bed rest did not seem to influence this development. These findings suggest that the routine low caloric feeding is capable of contributing to postoperative insulin resistance.
authors.affiliation: Department of Surgery at Gastrocentrum, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Svanfeldt
authors.forename: A
authors.initials: A
authors.lastname: Thorell
authors.forename: K
authors.initials: K
authors.lastname: Brismar
authors.forename: J
authors.initials: J
authors.lastname: Nygren
authors.forename: O
authors.initials: O
authors.lastname: Ljungqvist
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001510:Bed Rest / Q000706:statistics & numerical data*; D031204:Caloric Restriction / Q000706:statistics & numerical data*; D002153:Calorimetry, Indirect; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000139:chemically induced; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D007332:Insulin Infusion Systems; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D011182:Postoperative Care / Q000009:adverse effects*; D012016:Reference Values; D013997:Time Factors
chemical_list: D007328:Insulin; D005947:Glucose