[Gene therapy of hypertension].
Hypertension is a disease caused by multiple genes. The traditional treatments have many defects. A gene therapy has been proposed where antisense oligonucleotide (AS ODN) is developed to specifically block the expression of hypertension candidate genes. It is of long-term effect, high efficiency and non toxicity. Preliminary results are encouraging, but much work needs to be done before gene therapy could be applied to humans.
Wang
Z G
ZG
Department of Hypertension, Institute of Cardiopulmonary Vascular Disease, Beijing 100029.
Wen
S J
SJ
Wu
Z S
ZS
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000627:therapeutic use*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D012083:Renin / Q000235:genetics
D016376:Oligonucleotides, Antisense; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A; D012083:Renin