title: Asymmetric halo aldol reaction (AHA).
abstract: [reaction: see text] The asymmetric halo aldol reaction (AHA) using Evans oxazolidinones as chiral auxiliaries has been established for tandem I-C/C-C bond formations. The new asymmetric reaction provides a practical approach to a variety of halo aldols of a non-Evans type that cannot be easily synthesized by other methods. Excellent diastereoselectivity (>95%) and yields (80-93%) have been obtained for eight examples.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA. qeggl@ttu.edu
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Dianjun
authors.initials: D
authors.lastname: Chen
authors.forename: Cody
authors.initials: C
authors.lastname: Timmons
authors.forename: Michael D
authors.initials: MD
authors.lastname: Carducci
authors.forename: Allan D
authors.initials: AD
authors.lastname: Headley
mesh_terms: D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D023303:Oxazolidinones