Localized amyloidosis of the glans penis: a case report and literature review.
BACKGROUND
Primary localized cutaneous amyloidosis is an uncommon lesion with a varied pathogenesis.


METHODS
We report the case of a 67-year-old-male discovered to have a localized amyloid lesion of the glans penis.


RESULTS
Biopsy of the lesion revealed dermal deposits of amorphous eosinophilic material which stained positive with Congo red and amyloid P protein. Additional stains, including kappa and lambda light chains, amyloid A, and transthyretin, were negative. The lesion has remained asymptomatic, with no evidence of systemic disease identified, and no further treatment has been necessary.


CONCLUSIONS
This is the sixth reported case of localized amyloidosis of the glans penis. Based on the clinical behavior and pathologic characteristics, this type of lesion is best classified as primary localized cutaneous amyloidosis, in the same family as the macular/lichenoid type lesions.
Ritter
Marylynn
M
Department of Pathology, University of South Florida, Tampa, FL, USA. mritter@hsc.usf.edu
Nawab
Rehana A
RA
Tannenbaum
Myron
M
Hakky
Said I
SI
Morgan
Michael B
MB
D000368:Aged; D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010409:Penile Diseases / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology