[Changes of NK cell's activity and T lymphocyte subpopulation in peripheral blood of patients with laryngocarcinoma].
OBJECTIVE
By detecting the changes of NK cell's activity and T lymphocyte subpopulation in the peripheral blood of the patients with laryngocarcinoma, the immune function level of the patients could be judged and the prognosis of the patients could be predicted.


METHODS
The NK cell's activity in 47 patients with laryngocarcinoma was tested, and T lymphocyte subpopulation in 35 patients were detected with flow cytometer, and compared with the normal control group of 45 volunteers and the group of 15 patients with polyp of vocal cord.


RESULTS
The NK cell's activity in the patients with laryngocarcinoma was lower than both of the normal control group and the polyp of vocal cord patients group, and the more severe was the degree of disease, the lower of the NK cell's activity was. The NK cell's activity in the pharyngocacinoma patients group in the 3-6 days after operation was lower than that in preoperation significantly; in the same time when the NK cell's activity was droping, CD3 and the ratio of CD4/CD8 became lower.


CONCLUSIONS
By detecting the changes of both NK cell's activity and the T lymphocyte subpopulation in patients with laryngocarcinoma, the immune function level of the patients can be judged objectively, which is of the important clinic significance.
Kou
F
F
Department of Otolaryngology, Shandong Provincial Hospital, Jinan 250021.
Qi
S
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007822:Laryngeal Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*