[Evaluation of 99mTc(V)-DMSA imaging in patients with pharyngolaryngeal carcinoma].
OBJECTIVE
To evaluate the value of tumor-seeking agent 99mTc(V)-DMSA in patients with pharyngolaryngeal carcinoma and its biodistribution in human being.


METHODS
Planar and SPECT scintigraphy with 99mTc(V)-DMSA were performed in 12 patients with histologically confirmed pharyngolaryngeal carcinoma. The dynamic distribution in patients was also analyzed.


RESULTS
9 cases (11 lesions) showed increased uptake by planar imaging and 11 cases (19 lesions) were clearly demonstrated by SPECT images. Furthermore, distant metastatic lesions were showed in 5 patients. Biodistribution in patients showed the accumulation of 99mTc(V)-DMSA in kidney was significantly greater than other organs.


CONCLUSIONS
These results could suggested the clinical utility of 99mTc(V)-DMSA, specially with SPECT, for detecting primary pharyngolaryngealcarcinoma and their metastatic lesions (both local and distant). 99mTc(V)-DMSA Tumor-seeking agent Pharyngolaryngeal carcinoma.
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Department of Nuclear Medicine, Union Hospital, Tongji Medical University, Wuhan 430022.
Bender
H
H
Gurke
M
M
Biersack
H J
HJ
D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D010610:Pharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid