[Effects of losartan on renal ultrastructure in diabetic rats].
OBJECTIVE
To observe the effects of losartan on renal ultrastructure in streptozotocin diabetic rats.


METHODS
Male SD rats were randomly divided into 2 groups: normal control group (NC group) and diabetic group. Diabetic group was induced by streptozocin (65 mg.kg-1) abdominal injection. Four weeks later, diabetic rats were further divided into 2 groups: diabetic rats treated with losartan (DL group, 20 mg.kg-1.d-1, by gavage) and diabetic unteated control group (DC group). Renal ultrastructure of each group was observed before and after 12 weeks of treatment respectively.


RESULTS
The ultrastructure alterations in DL group including mesangial expansion and thickening of glomerular basement membrane (GBM), were lighter than those in DC group.


CONCLUSIONS
Losartan can prevent renal pathological progress in diabetic rats. It is suggested that losartan may have some renal protective effects.
Zhoung
H J
HJ
Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhang
D M
DM
Zhou
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure*; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D019808:Losartan