title: Alternative splicing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses.
abstract: More than 10 splice variants of the Fc receptor for IgA (Fc alpha R, CD89) have been identified in human myeloid cells. In this study, we quantified Fc alpha R splice transcripts Delta EC2 and Delta 66 EC2, which lack the entire and a part of the homologous immunoglobulin-like extracellular domain 2 (EC2), respectively. Tumor necrosis factor-alpha was found to specifically increase the ratio of Delta EC2 to the wild type CD89 in neutrophils and conversely decrease the Delta EC2 ratio in monocytes. We also observed a significant decrease in the neutrophil Delta EC2/CD89 ratio in pneumonia patients. These results suggest that Delta EC2 is differentially regulated and could be involved in immunoregulation of IgA-mediated host defense.
authors.affiliation: Allergy Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Togo
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Shimokawa
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: Chisei
authors.initials: C
authors.lastname: Ra
mesh_terms: D017398:Alternative Splicing / Q000187:drug effects / Q000235:genetics* / Q000276:immunology*; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D022423:Myeloid Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011014:Pneumonia / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism; D011961:Receptors, Fc / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D020298:U937 Cells
chemical_list: D015703:Antigens, CD; C036832:Fc(alpha) receptor; D012333:RNA, Messenger; D011961:Receptors, Fc; D014409:Tumor Necrosis Factor-alpha; D013755:Tetradecanoylphorbol Acetate