Peripheral benzodiazepine receptors: on mice and human brain imaging.
There are numerous methods designed to monitor brain neuropathologies resulting from a wide arsenal of insults. Regardless of the cause of neuronal death, reactive glial cells always appear at and around the site of degeneration. These cells are distinguished by the exceptional abundance of peripheral benzodiazepine receptors, particularly compared with surrounding neurons. Measuring the binding of specific ligands to these peripheral benzodiazepine receptors offers a unique indirect marker for reliable damage assessment in the CNS and a faithful indicator for the accompanying cognitive deficits.
Weissman
Ben Avi
BA
Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona, Israel. baw@iibr.gov.il
Raveh
Lily
L
D000818:Animals; D001345:Autoradiography; D001570:Benzodiazepinones / Q000493:pharmacokinetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D002250:Carbon Radioisotopes; D005911:Gliosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics; D008024:Ligands; D051379:Mice; D011237:Predictive Value of Tests; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000378:metabolism*; D013379:Substrate Specificity; D014055:Tomography, Emission-Computed; D014316:Tritium
D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D007546:Isoquinolines; D008024:Ligands; D011963:Receptors, GABA-A; D014316:Tritium; C028513:4'-chlorodiazepam; C037850:PK 11195