[The malignant side of chronic inflammatory bowel disease].
Patients with chronic inflammatory bowel disease (IBD) have a higher risk of colorectal carcinoma, and present with this malignancy at a younger age than non-IBD individuals. In three patients, two men aged 20 and 36 years and one woman aged 34 years, colorectal cancer developed at a young age, following a long history of ulcerative colitis. Surveillance for colorectal cancer in IBD patients needs to be performed by regular colonoscopy with extensive biopsy sampling for the detection of dysplasia, regarded by many as predictive for colon carcinoma. Whenever a dysplasia-associated lesion or mass or a highgrade dysplasia is identified, there is a strong indication for colectomy. When low-grade dysplasia is found, the findings should be discussed with the patient and it should be decided whether the patient should resume surveillance or opt for colectomy.
West
R L
RL
Afd. Maag-, Darm- en Leverziekten, Erasmus Universitair Medisch Centrum, Postbus 2040, 3000 CA Rotterdam. west@mdl.azr.nl
van de Vrie
W
W
Schouten
W R
WR
van Dekken
H
H
Kuipers
E J
EJ
D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors