[Zinc ions: an endogenous neuromodulator].
Zinc ions are widely distributed in the central nervous system. Zinc ions are released from neurons in a calcium-dependent manner. In recent years abundant evidence indicates that zinc ions modulate not only the release of transmitters, but also the voltage- and ligand (excitatory and inhibitory amino acids)-gated channels, suggesting that these ions may serve as an important endogenous neuromodulator.
Luo
D G
DG
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031.
Yang
X L
XL
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D054815:Cyclic Nucleotide-Gated Cation Channels; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000502:physiology; D018079:Receptors, GABA / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D015032:Zinc / Q000502:physiology*
D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels; D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D015032:Zinc