title: Elevated serum estradiol suggesting recurrence of Leydig cell tumor nine years after radical orchiectomy.
abstract: We report a case of a Leydig cell tumor that showed retroperitoneal lymph node metastasis 9 years after radical orchiectomy. Elevated serum estradiol (E2) suggested recurrence of the Leydig cell tumor. Retroperitoneal lymph node dissection (RPLND) was performed and the lymph node was proved histopathologically to have a metastatic Leydig cell tumor. After RPLND, serum E2 returned to the normal range. This is the first reported case in which changes in the endocrinological findings were useful as likely tumor markers to detect the recurrence of a Leydig cell tumor.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Itoh
authors.forename: Ko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D004958:Estradiol / Q000097:blood*; D006801:Humans; D007984:Leydig Cell Tumor / Q000097:blood* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000601:surgery*; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000097:blood* / Q000601:surgery*; D013997:Time Factors
chemical_list: D004958:Estradiol