title: The role of proteolysis in tumor invasiveness in glioblastoma and metastatic brain tumors.
abstract: Local invasive infiltration and growth are key features in glioblastoma, which are accompanied by remodeling of the vasculature and the destruction of the surrounding normal brain tissues. The local and regional spread of glioblastoma is often associated with poor prognosis. The invasive character of glioblastoma appears to depend partly on the proteolytic destruction of the extracellular matrix components. In this article, we review the role of proteolytic enzymes, urokinase-type plasminogen activator and matrix-metalloproteases, for diffuse infiltrative growth of glioblastoma. An understanding of the mechanisms of increased expression of these molecules in glioblastoma might provide an insight into the regulatory pathway of cellular invasion and for a new therapeutic strategy for glioblastoma.
authors.affiliation: Department of Neurosurgery, Fukuoka University School of Medicine, 45-1, 7-chome, Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. masaaki@fukuoka-u.ac.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ueno
authors.forename: Shuji
authors.initials: S
authors.lastname: Hayashi
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukushima
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000201:enzymology* / Q000473:pathology*; D005909:Glioblastoma / Q000201:enzymology* / Q000473:pathology* / Q000556:secondary; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010447:Peptide Hydrolases / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010447:Peptide Hydrolases; D014568:Urokinase-Type Plasminogen Activator; D020782:Matrix Metalloproteinases