title: Antifungal constituents of the stem bark of Bridelia retusa.
abstract: Antifungal activity guided fractionation of solvent extracts of the stem bark of Bridelia retusa of the family Euphorbiaceae against Cladosporium cladosporioides, furnished new bisabolane sesquiterpenes, (E)-4-(1,5-dimethyl-3-oxo-1-hexenyl)benzoic acid, (E)-4-(1,5-dimethyl-3-oxo-1,4-hexadienyl) benzoic acid, (R)-4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid and (-)-isochaminic acid, together with the known (R)-4-(1,5-dimethyl-3-oxohexyl)benzoic acid (ar-todomatuic acid), 5-allyl-1,2,3-trimethoxybenzene (elemicin), (+)-sesamin and 4-isopropylbenzoic acid (cumic acid). All these compounds showed fungicidal activity on TLC bioautography method at very low concentrations except elemicin.
authors.affiliation: Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka. lalith@ifs.ac.lk
authors.forename: Lalith
authors.initials: L
authors.lastname: Jayasinghe
authors.forename: B M Mallika
authors.initials: BM
authors.lastname: Kumarihamy
authors.forename: K H R Nishantha
authors.initials: KH
authors.lastname: Jayarathna
authors.forename: N W M Gayathri
authors.initials: NW
authors.lastname: Udishani
authors.forename: B M Ratnayake
authors.initials: BM
authors.lastname: Bandara
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Hara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects*; D019665:Euphorbiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013188:Sri Lanka
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes