title: Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding.
abstract: We used single photon emission computed tomography (SPECT) to study striatal [(123)I]beta-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [(123)I]beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.
authors.affiliation: Department of Clinical Neurology, University of Vienna, Austria. shappe@gwdg.de
authors.forename: Svenja
authors.initials: S
authors.lastname: Happe
authors.forename: Walter
authors.initials: W
authors.lastname: Pirker
authors.forename: Gerhard
authors.initials: G
authors.lastname: Klösch
authors.forename: Cornelia
authors.initials: C
authors.lastname: Sauter
authors.forename: Josef
authors.initials: J
authors.lastname: Zeitlhofer
mesh_terms: D000368:Aged; D003042:Cocaine / Q000031:analogs & derivatives*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D020189:Nocturnal Myoclonus Syndrome / Q000378:metabolism / Q000503:physiopathology*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D017286:Polysomnography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine