Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density.
We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using (18)F-methylspiperone PET in this very late stage of chronic manganism, supporting the hypothesis that manganese intoxication may trigger a neurodegenerative disease process.
Kessler
Kirn R
KR
Department of Neurology, J.W. Goethe University, Frankfurt-Main, Germany. k.kessler@em.uni-frankfurt.de
Wunderlich
Gilbert
G
Hefter
Harald
H
Seitz
Rüdiger J
RJ
D000368:Aged; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis; D003342:Corpus Striatum / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D020149:Manganese Poisoning / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D019578:Multiple System Atrophy / Q000378:metabolism / Q000473:pathology; D009483:Neuropsychological Tests; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D017448:Receptors, Dopamine D2