title: Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease.
abstract: Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.
authors.affiliation: IVAX Research, 4400 Biscayne Boulevard, Miami, FL 33137, USA. Nicholas_Bodor@ivax.com
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bodor
authors.forename: Peter
authors.initials: P
authors.lastname: Buchwald
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D001921:Brain / Q000187:drug effects; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations