[The changes of serum angiotensin converting enzyme activity in Type 2 diabetes and its vascular complications].
This investigation was made with reference to the changes of serum angiotensin converting enzyme (SACE) activity in type 2 diabetes and its vascular complications. SACE activity was studied in 127 type 2 diabetic patients and 90 healthy persons by using a spectrophotometric assay. The results showed SACE activity was obviously higher in diabetic patients (459.51 +/- 175.85 U) than in healthy persons (321.14 +/- 121.27 U); SACE activity was significantly higher in type 2 diabetic patients with diabetic nephropathy (548.27 +/- 166.60 U) than in patients without diabetic nephropathy (383.2 +/- 139.00 U), but there was no difference between patients with microalbuminuria and macroalbuminuria; no statistical difference was detected in SACE activity between diabetic patients with diabetic retinopathy (465.64 +/- 178.93 U) and without retinopathy (449.07 +/- 170.04 U); SACE activity was not associated with the course of diabetes, blood pressure, blood lipid and blood glucose. These data suggest that raised SACE activity might only play a role in the initiation of type 2 diabetes and diabetic nephropathy, but not relate to the progress of diabetic nephropathy, the onset of diabetic retinopathy and hypertension.
Wu
H
H
Department of Gerontology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Qu
S
S
Zhang
Y
Y
Deng
J
J
Li
J
J
Zhou
J
J
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D003928:Diabetic Nephropathies / Q000201:enzymology*; D003930:Diabetic Retinopathy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*
D007703:Peptidyl-Dipeptidase A