title: Quality of life after a diagnosis of prostate cancer among men of lower socioeconomic status: results from the Veterans Affairs Cancer of the Prostate Outcomes Study.
abstract: OBJECTIVE
  To evaluate prospectively the health-related and disease-specific quality of life (QOL) at diagnosis and during the first year thereafter for patients with newly diagnosed prostate cancer who received care at Veterans Affairs Medical Centers.
  
  
  METHODS
  Interviewers administered the European Organization for Research and Treatment of Cancer-QOL Questionnaire, a valid and reliable measure of health status, to 140 patients with prostate cancer at baseline (at diagnosis, before the initiation of treatment) and at 3 and 12 months thereafter at five Veterans Affairs Medical Centers. The mean changes from baseline values were analyzed statistically for patients with localized disease stratified by treatment group and separately for patients with metastatic disease.
  
  
  RESULTS
  Among the 98 men with localized prostate cancer, significant disease-specific QOL changes noted at 3 and 12 months included worsening of urinary and sexual function among men treated with radical prostatectomy or radiotherapy and worsening of urinary function among those who opted for watchful waiting (each P <0.05). Among the 42 men with metastatic prostate cancer, significant decrements in role and social and sexual function were noted at 3 months, but had resolved on average by 12 months of follow-up.
  
  
  CONCLUSIONS
  At 12 months, disease-specific QOL decrements persisted for patients with localized disease, but for patients with metastatic disease, disease-specific QOL appeared to return to near baseline (at diagnosis, before treatment initiation) function. Our study, among the first to assess the QOL at baseline before treatment, provides meaningful information on general treatment effects, which are directly relevant to clinicians when discussing treatment options with patients.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Medical School, Chicago, Illinois 60611, USA.
authors.forename: Amy K
authors.initials: AK
authors.lastname: Siston
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Knight
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Slimack
authors.forename: Joan S
authors.initials: JS
authors.lastname: Chmiel
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nadler
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Lyons
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Kuzel
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Moran
authors.forename: Roohollah
authors.initials: R
authors.lastname: Sharifi
authors.forename: Charles L
authors.initials: CL
authors.lastname: Bennett
mesh_terms: D000368:Aged; D015897:Comorbidity; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010353:Patient Education as Topic; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D011788:Quality of Life; D012923:Social Class; D011795:Surveys and Questionnaires; D014481:United States; D014493:United States Department of Veterans Affairs; D014728:Veterans / Q000523:psychology