[The influence of labyrinthectomy on the expression of NMDA R1 mRNA].
OBJECTIVE
To study the effect of labyrinthectomy on the expression of NMDAR1 (N-methyl-D-aspartate receptor subunit R1).


METHODS
The in situ hybridization was used to observe the expression of NMDA R1mRNA post-unilateral labyrinthectomy and investigate its effect on vestibular compensation.


RESULTS
20 h post-unilateral labyrinthectomy, the NMDA R1mRNA positive neurons in the medial vestibular nucleus increased significantly compared with the unlesioned side(P < 0.01). 40 h-6 d, the positive cells decreased gradually. 6 d post lesion, the positive neuron counts of the lesioned side had no significant difference compared with those of the un-lesioned side (P > 0.05).


CONCLUSIONS
The changing trend of the expression of NMDA R1mRNA in the medial vestibular nucleus is related to the recovery of the vestibular static symptoms after unilateral labyrinthectomy. It is suggested that the modulation of the efficacy of the NMDA R1 play an important role in the compensation of the static symptoms.
Wang
J
J
Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Wu
Z
Z
Wang
E
E
Jiang
H
H
Liu
S
S
D000818:Animals; D007758:Ear, Inner / Q000601:surgery*; D006168:Guinea Pigs; D012333:RNA, Messenger / Q000096:biosynthesis; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis*; D014726:Vestibular Nuclei / Q000378:metabolism*
D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate