A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage.
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.
Zayat
Leonardo
L
Departamento de Química Inorgánica, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, AR1428EHA Buenos Aires, Argentina.
Calero
Cecilia
C
Alborés
Pablo
P
Baraldo
Luis
L
Etchenique
Roberto
R
D015082:2,2'-Dipyridyl / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry* / Q000493:pharmacokinetics; D015761:4-Aminopyridine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005724:Ganglia / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D007865:Leeches; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D010084:Oxidation-Reduction; D010777:Photochemistry; D026902:Potassium Channel Blockers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
D004337:Drug Carriers; D009942:Organometallic Compounds; D026902:Potassium Channel Blockers; C472812:dichlorobis(2,2'-bipyridine)(4-aminopyridine)ruthenium; D015082:2,2'-Dipyridyl; D015761:4-Aminopyridine