Localization of c-Fos protein in the rat spinal cord after carrageenan treatment.
We have characterized segmental and laminar distribution patterns of Fos-immunopositive (Fos-IP) neurons in spinal cord segments L3-L6 after carrageenan treatment. A large number of Fos-IP neurons was found in the medial region of the ipsilateral dorsal horn laminae I-II at 4 and 6 h postinjection (pi). At one day pi, the number of Fos-IP neurons was decreased significantly, which correlated with suppression of inflammation in the affected hind paw. Bilaterally, Fos-IP neurons reappeared in the L3-L6 spinal cord segments at 3-4 days pi, mainly in the deep laminae LV-LVI. However, signs of inflammation had distinctly attenuated. Our data indicate a biphasic trend in Fos-IP in this experimental model of inflammation.
Jergová
Stanislava
S
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic. jergova@saske.sk
Cízková
Dása
D
Orendácová
Judita
J
Cízek
Milan
M
Marsala
Jozef
J
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D006614:Hindlimb / Q000187:drug effects / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
D016760:Proto-Oncogene Proteins c-fos; D002351:Carrageenan