title: Argatroban in adult extracorporeal membrane oxygenation.
abstract: This case report addresses the use of Argatroban, an anticoagulant and thrombin inhibitor for treatment of thrombocytopenia in an adult patient on extracorporeal membrane oxygenation (ECMO). After 5 days on ECMO, the patient showed signs of heparin-induced thrombocytopenia (HIT) with a platelet count of 20K. Argatroban was initiated to decrease progression of HIT and continue treatment with ECMO proved to be successful. Given the occurrence of HIT with heparin therapy, a need for alternate drug therapy is required for patients requiring treatment with ECMO. The use of Argatroban in adult ECMO is outlined and includes dosage, monitoring, and patient treatment.
authors.affiliation: Department of Cardiothoracic Surgery, The University of Texas Southwestern Medical Center at Dallas, 75390-8879, USA. johnstonr@sbcglobal.net
authors.forename: Nicklett
authors.initials: N
authors.lastname: Johnston
authors.forename: Michael
authors.initials: M
authors.lastname: Wait
authors.forename: Lynne
authors.initials: L
authors.lastname: Huber
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage* / Q000627:therapeutic use; D000991:Antithrombins / Q000008:administration & dosage* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D020099:Coated Materials, Biocompatible / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D010875:Pipecolic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D013449:Sulfonamides; D013781:Texas; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D020099:Coated Materials, Biocompatible; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban