[Experimental study on basic fibroblast growth factors in viral myocarditis].
In order to know earlier pathological changes in myocarditis, 8 rats were inoculated with CVB3, and a model of viral myocarditis was built. The changes of basic fibroblast growth factors (bFGF) in acute viral myocarditis were observed by immunohistochemistry. It was found that the bFGF stain started to show positive at the third day after viral infection and that the positive degree increased afterwards. With normal HE staining, obvious lesion usually appeared under microscopy at least five days after infection. This suggests that the changes of bFGF in myocardium can be used for examination of early and light lesions of viral myocarditis.
Zha
G
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Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Gungzhou 510080.
D000818:Animals; D003384:Coxsackievirus Infections / Q000473:pathology*; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D009205:Myocarditis / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
D016222:Fibroblast Growth Factor 2