Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides.
Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion.
Li
Qing
Q
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
Su
Bin
B
Li
Hui
H
Meng
Xiang-Bao
XB
Cai
Meng-Shen
MS
Li
Zhong-Jun
ZJ
Zhou
Rou-Li
RL
Suo
Ta-Lin
TL
D000606:Amino Sugars / Q000138:chemical synthesis* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D006031:Glycosylation; D006801:Humans; D007797:Laminin; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D014407:Tumor Cells, Cultured
D000606:Amino Sugars; D007797:Laminin; C000458:N-acetyllactosamine