title: HLA and genetic susceptibility to sleepwalking.
abstract: HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0%) were DQB1*0501 positive vs eight (13.3%) controls (P = 0.0056; odds ratio = 3.5, 95% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.
authors.affiliation: Service de Psycopathologie de l'Enfant et de l'Adolescent, Hôpital Robert Dobré, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lecendreux
authors.forename: C
authors.initials: C
authors.lastname: Bassetti
authors.forename: Y
authors.initials: Y
authors.lastname: Dauvilliers
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: E
authors.initials: E
authors.lastname: Neidhart
authors.forename: M
authors.initials: M
authors.lastname: Tafti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D013009:Somnambulism / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen