title: Pulmonary large cell carcinoma with rhabdoid phenotype.
abstract: A 70-year-old woman presented with a coin lesion in her left lung. The tumor was well circumscribed and had a large area of central necrosis with a thin rim of viable tumor cells. It showed a solid growth pattern of polygonal cells with eosinophilic intracytoplasmic inclusion bodies. Immunohistochemically, the tumor cells were positive for vimentin, neural cell adhesion molecule, neuron-specific enolase, and vascular endothelial growth factor. Electron microscopy revealed intracytoplasmic inclusion bodies consisting of whorled intermediate filaments. Based on histological and immunohistochemical findings, the patient was diagnosed as having pulmonary large cell carcinoma with rhabdoid phenotype (LCCRP). The patient was in stage IA, and the histological findings may be the prototype of pure LCCRP. The tumor recurred after 6 years, and the second tumor had more apparent intracytoplasmic inclusion bodies. It is worthwhile detecting and recognizing the significance of these intracytoplasmic inclusions because of the poor prognosis of this tumor.
authors.affiliation: Department of Basic Pathology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kenzo@med.m.chiba-u.ac.jp
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Shimamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Toyozaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Haga
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohwada
authors.forename: Akira
authors.initials: A
authors.lastname: Iyoda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sekine
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iizasa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018287:Carcinoma, Large Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008854:Microscopy, Electron; D009363:Neoplasm Proteins / Q000032:analysis; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins