[Hepatitis B--a viral oncogene?].
Infection with hepatitis B virus may develop into a chronic carrier state, which may result in chronic hepatitis, cirrhosis and hepatocellular carcinoma, but the exact mechanism of the development of hepatocellular carcinoma is still not known. The question is whether it is hepatitis B virus itself or the cellular changes due to persistent hepatitis B virus infection that cause malignant changes? The purpose of this article was to describe the natural history of hepatitis B virus infection together with epidemiological, serological, and molecular data that show a connection between chronic hepatitis B virus infection and the development of hepatocellular carcinoma.
Weis
Nina M
NM
H:S Hvidovre Hospital, infektionsmedicinsk afdeling, klinisk forskningsenhed, DK-2650 Hvidovre.
Krogsgaard
Kim
K
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000517:prevention & control / Q000821:virology*; D002648:Child; D014943:Global Health; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000821:virology*; D009858:Oncogenic Viruses / Q000276:immunology; D015995:Prevalence
D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines