title: Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.
abstract: Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Obihiro, Hokkaido 080-8555, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nagai
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yokoyama
authors.forename: Tomohide
authors.initials: T
authors.lastname: Matsuo
authors.forename: Sabine
authors.initials: S
authors.lastname: Bork
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Hirata
authors.forename: Xuenan
authors.initials: X
authors.lastname: Xuan
authors.forename: Yinchang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Florencia G
authors.initials: FG
authors.lastname: Claveria
authors.forename: Kozo
authors.initials: K
authors.lastname: Fujisaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Igarashi
mesh_terms: D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D001403:Babesia / Q000187:drug effects* / Q000254:growth & development; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D011739:Pyrimethamine / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C004331:pamaquine; D011739:Pyrimethamine