[Development of technology of the enzyme preparation: procelan ointment].
When investigating the release of procelan from diphilic, hydrophobic and hydrophilic basis we determined that the best release of the active substance is from hydrophilic basis. The macrogolic base when compared with methylcellulosic one shows clearly expressed osmotic properties and therefore is more suitable as a base for ointments intended to treat suppurative wounds. This was confirmed by treatment of experimentally excited suppurative wounds on rabbits. Hydrophilic ointments containing lyophilized procelan powders from 4 per cent to 20 per cent were examined. The most remarkable therapeutic effect reached with the ointment of macrogolic base, optimal concentration of procelan being 10 per cent. The method of assay of procelan in the ointment was created. The created dosage form is stable for three years at room temperature.
Puodziūniene
Gene
G
Kauno medicinos universiteto Farmacines chemijos ir farmakognozijos katedra, Mickeviciaus 9, 3000 Kaunas.
Vaiciuvenas
Vytautas
V
Janulis
Valdimaras
V
Steponavicius
Juozas
J
D000818:Animals; D000891:Anti-Infective Agents, Local; D003627:Data Interpretation, Statistical; D003879:Dermatologic Agents; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D009823:Ointment Bases; D009824:Ointments; D009995:Osmosis; D010447:Peptide Hydrolases; D011817:Rabbits; D013492:Suppuration / Q000188:drug therapy; D014946:Wound Infection / Q000188:drug therapy; D014947:Wounds and Injuries / Q000188:drug therapy*
D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D009823:Ointment Bases; D009824:Ointments; D010447:Peptide Hydrolases