title: Effect of excessive intake of thermally oxidized sesame oil on lipids, lipid peroxidation and antioxidants' status in rats.
abstract: Fresh and thermally oxidized sesame, groundnut and coconut oils were fed to different groups of rats, as high fat diet (20%). Feeding fresh and thermally oxidized oils increased the levels of total cholesterol, low density lipoprotein cholesterol (LDL-C), and phospholipids but high density lipoprotein cholesterol (HDL-C) decreased in all the experimental animals. The levels of very low density lipoproteincholesterol (VLDL-C) and triacylglycerol increased only in groundnut and coconut oils-fed groups and decreased in sesame oil-fed group when compared with the control. When fresh and the corresponding thermally oxidized oils-fed groups were compared with the control, total cholesterol and LDL-cholesterol alone increased while triacylglycerol, VLDL-cholesterol, HDL-cholesterol, HDL/LDL ratio and phospholipids decreased. Thiobarbituric acid reacting substances increased in all the experimental animals and more so in corresponding thermally oxidized oils. It was less pronounced in sesame oil-fed groups when compared with the corresponding other oils-fed groups. Feeding of thermally oxidized oils decreased the levels of vitamin E, vitamin C and reduced glutathione when compared with fresh oils. Among the three thermally oxidized edible oils, sesame oil exhibited lesser risk for hyperlipidemic disorders.
authors.affiliation: Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu 608 002, India.
authors.forename: K N
authors.initials: KN
authors.lastname: Srinivasan
authors.forename: K V
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood* / Q000145:classification; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D012715:Sesame Oil; D002784:Cholesterol