title: [Effects of prostaglandin E1 on hepatic function and hepatofibrosis in patients with chronic hepatitis B].
abstract: To search for an effective drug to cure patients with chronic hepatitis B. Twenty eight patients with chronic hepatitis B were treated with prostaglandin E1. The comprehensive indexes, including glutamic pyruric tranasaminase (GPT), serum total bilirubin (TBIL), total bile acid (TBA), hyaluronic acid (HA) and precollagen type III (PCIII), were examined before and after treatment. The levels of GPT, TBIL, TBA, HA, PCIII after 1 month of the treatment were significantly lower than those before the treatment (P < 0.05), there were significant differences between the treated and the controlled group patients with chronic hepatitis B (P < 0.05). The results suggest that the treatment with PGE1 might improve hepatic function, and resist the hepatic fibrosis in patients with chronic hepatitis B.
authors.affiliation: Department of Infectious Diseases, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Gong
authors.forename: K Q
authors.initials: KQ
authors.lastname: Wang
authors.forename: S G
authors.initials: SG
authors.lastname: Tang
authors.forename: W J
authors.initials: WJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000527:Alprostadil / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood; D024061:Collagen Type III / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
chemical_list: D024061:Collagen Type III; D006820:Hyaluronic Acid; D000410:Alanine Transaminase; D000527:Alprostadil; D001663:Bilirubin