Effects of minocycline alone and in combination with mild hypothermia in embolic stroke.
Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral artery (MCA). Infarct volume was measured at 48 h after the injury. Administration of minocycline alone or minocycline plus mild hypothermia reduced infarct volume significantly. However, mild hypothermia in combination with minocycline did not show any additive effect. These results suggest that minocycline is beneficial in focal ischemic brain injury, and the lack of the enhanced neuroprotection may be due to the brief exposure to hypothermia.
Wang
Chen Xu
CX
Stroke Research Laboratory, 533 HMRC, University of Alberta, T6G 2S2, Edmonton, Canada. chenxu@alberta.ca
Yang
Tao
T
Shuaib
Ashfaq
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D007036:Hypothermia, Induced; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D020766:Intracranial Embolism / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D016019:Survival Analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008911:Minocycline