title: [Impacts of clinicopathologic parameters on lymphatic metastasis of oral squamous cell carcinoma].
abstract: OBJECTIVE
  To evaluate the effects of clinicopathologic parameters on lymphatic metastasis of oral squamous cell carcinoma.
  
  
  METHODS
  One hundred and ninety-three patients who underwent therapy in our department were included in this study. Ten parameters (T and N stages, location, patterns of invasion, thickness, lymphocyte infiltration, karyokinesis count, degrees of differentiation, degrees of cell keratinization and nuclear polymorph) were evaluated to determine their effects on lymphatic metastasis of oral carcinoma using univariate and multivariate analysis.
  
  
  RESULTS
  By using the univariate analysis, five parameters (T and N stage, pattern and depth of invasion, lymphocyte infiltration) showed significant impacts on pathologic nodal metastasis. From multivariate analysis, however, only patterns of invasion were independent predictors of metastasis. Also, patterns of invasion were the only significant factors that influence the post-operative metastasis besides pattern of neck treatment.
  
  
  CONCLUSIONS
  The pattern of invasion is the most important parameter that influences the metastasis of oral squamous cell carcinoma.
authors.affiliation: College of Stomatology, Fourth Military Medical University.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Gu
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012307:Risk Factors