Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness.
Space motion sickness (MS) is one of the most important problems in the field of space medicine. In order to prevent space MS, a new medicine, PMPA, has been prepared by means of synthesizing in our laboratory. The purposes of this study were to set up animal models of PMPA against MS, and to observe its effects on anti-MS, and to prove its function of antagonism to choline. Eight cats, forty rabbits and two hundred and ten rats were selected as animal subjects. The parallel swing stimulus, a method causing the reversal syndromes and tests of anti-choline function were used in our experiments. The results are as follows: (1) The score of MS symptoms in cats with PMPA or scopolamine (SCOP) is significantly lower than that in cats with placebo (p<0.01), while the incidences of efficiency and prevention of PMPA (87.5%, 75%) are higher than those of SCOP (75.0%, 50%) in cats. (2) PMPA of 1.6 mg/kg or 0.8 mg/kg could antagonize the reversal syndromes and repress reversal rotation significantly in rabbits like SCOP in comparison with placebo (p<0.01). (3) PMPA could inhibit tremor evoked by oxotremorine or by nicotine-procaine in rats like SCOP, and play an important role in the antagonism to central M-choline and N-choline receptors. The animal experiments demonstrate that PMPA is an effective medicine against MS with antagonism function to choline.
Yang
T D
TD
Institute of Space Medico-Engineering, Beijing, China.
Pei
J S
JS
Yang
S L
SL
Liu
Z Q
ZQ
Sun
R L
RL
D000054:Acceleration; D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D002415:Cats; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D008297:Male; D023421:Models, Animal; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D012601:Scopolamine / Q000627:therapeutic use; D018489:Space Motion Sickness / Q000188:drug therapy* / Q000517:prevention & control*
D000932:Antiemetics; D018680:Cholinergic Antagonists; D004365:Drugs, Chinese Herbal; D010095:Oxotremorine; D012601:Scopolamine