The biology and physiology of somatostatin receptors.
The biology and therapeutic application of somatostatin and its receptors are reviewed. The focus is on recent literature and patents, especially with regard to the specific function of each somatostatin receptor subtype. Detailed mechanisms mediating the effects of somatostatin and its analogues remain to be elucidated. Nevertheless, progress is being made towards a clear picture of the cellular signalling and physiological changes regulated by somatostatin and its receptors.
Lu
Hong-Tao
HT
Berlex Biosciences, Department of Immunology, 15049 San Pablo Ave, Richmond, California 94804, USA. horuk@pacbell.net
Salamon
Hugh
H
Horuk
Richard
R