[An experimental study of effects of injection of pingyangmycin on activities of enzyme of endothelial cells].
OBJECTIVE
The objective of this study is to investigate the mechanism of acute trauma of endothelium after injection of Pingyangmycin.


METHODS
A total of 42 adult Wistar rats were divided randomly into experimental groups (24), positive control groups (12) and normal control group (6), and the rats in the experimental or the positive control groups were injected with Pingyangmycin or sodium morrhuate into the mesenteric veins respectively, and then the enzyme activity of hepatic endothelial cells and hepatocytes was examined histochemically 0.5, 1, 2, 4, 8 and 24 hours after injection.


RESULTS
After injection, the activity of 5'-nucleinase(5'-N) in hepatic endothelial cells and that of lactic dehydrogenase (LDH) and succinodehydrogenase (SDH) in hepatocytes decreased gradually, but that injected Pingyangmycin was less than that injected sodium morrhuate.


CONCLUSIONS
The trauma caused by Pingyangmycin is less than that caused by sodium morrhuate, but the reaction of trauma caused by both is nonspecific.
Gao
Q
Q
College of Stomatology, West China University of Medical Sciences.
Wang
C
C
Wen
Y
Y
Xiao
B
B
Cheng
W
W
D015720:5'-Nucleotidase / Q000187:drug effects*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology*; D006392:Hemangioma, Cavernous / Q000188:drug therapy; D022781:Hepatocytes / Q000187:drug effects / Q000201:enzymology*; D015552:Injections, Intralesional; D007770:L-Lactate Dehydrogenase / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C021771:zhengguangmycin; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D015720:5'-Nucleotidase