[Separation and determination of pseudoephedrine in bufferin cold tablet by capillary electrophoresis with hydropropyl-beta-cyclodextrin as chiral selective reagent].
A method for the separation and analysis of the chiral pseudoephedrine enantiomers using capillary electrophoresis was established. The buffer solution for separation was 25 mmol/L Tris-phosphate, including 38 mmol/L hydropropyl-beta-cyclodextrin with pH value of 2.65. (1S, 2S)(+) Pseudoephedrine in Bufferin Cold tablet was determined. The method has good precision, recovery and linear relationship.
Wu
X F
XF
College of Pharmaceutical Science, Second Military Medical University, Shanghai 200433, China.
Chai
Y F
YF
Liu
L L
LL
Lou
Z Y
ZY
Li
J W
JW
Zhang
G Q
GQ
Wang
B
B
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003505:Cyclodextrins; D004338:Drug Combinations; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods; D004809:Ephedrine / Q000302:isolation & purification*; D013237:Stereoisomerism; D013607:Tablets; D014662:Vasoconstrictor Agents / Q000302:isolation & purification; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004338:Drug Combinations; D013607:Tablets; D014662:Vasoconstrictor Agents; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D004809:Ephedrine