[Biocompatibility of self-designed absorbable hydroxyapatite/poly (DL-lactide) composites].
The biocompatibility of self-designed hydroxyapatite/poly (DL-lactide) rods was evaluated both in vitro and in vivo including Ames test, micronucleus test, acute and subacute systemic toxicity test, hemolysis test, hemopexis test and long-term muscle and bone implant test. The results indicate that the material has no toxicity, no stimulation and mutation, and it does not cause hemolysis and hemopexis. Consequently, the biocompatibility of the composite was good.
Guo
X
X
Department of Orthopaedics, Union Hospital of Tongji Medical University, Wuhan 430022.
Zheng
Q
Q
Du
J
J
Zen
H
H
Quan
D
D
Yan
Y
Y
Li
S
S
Li
X
X
D020341:Absorbable Implants; D000818:Animals; D005260:Female; D006882:Hydroxyapatites; D008297:Male; D008422:Materials Testing; D012275:Oryza; D011091:Polyesters; D011817:Rabbits
D006882:Hydroxyapatites; D011091:Polyesters; C033616:poly(lactide)