title: Invasive carcinoma of the pancreas derived from intraductal papillary adenocarcinoma without mucin hypersecretion but with changes in the pancreatic duct on pancreatography.
abstract: We present a case of invasive carcinoma of the pancreas derived from intraductal papillary adenocarcinoma without mucin hypersecretion in a 65-year-old man with a 45-year history of alcohol abuse and a 2-year follow-up of chronic pancreatitis. Two years previously, in May 1998, he was admitted for investigation of abdominal pain. Computed tomography (CT) showed diffuse dilation of the main pancreatic duct with atrophy of the pancreatic parenchyma. Endoscopic retrograde pancreatography (ERP) showed a diffusely dilated main pancreatic duct with irregular side branches in the head of the pancreas. Chronic alcoholic pancreatitis was diagnosed on the basis of the pancreatography findings. The patient was readmitted for investigation of progressive weight loss in August 2000. Serum CA19-9 levels were markedly elevated (750 U/ml) and CT showed enlargement of the head and body of the pancreas. ERP showed irregularity of the main pancreatic duct in the head of the pancreas, and the distal main pancreatic duct (which was dilated on initial ERP examination) was interrupted in the body of the pancreas. Suspected pancreatic carcinoma was diagnosed, and pylorus-preserving pancreatoduodenectomy was performed. Frozen section examination of the cut end of the pancreas revealed ductal carcinoma, and total pancreatoduodenectomy with portal vein resection was performed. Histologically, the resected tumor was diagnosed as an invasive carcinoma derived from intraductal papillary adenocarcinoma without mucin hypersecretion. We recommend observing changes in the pancreatic duct on pancreatography to diagnose invasive carcinoma of the pancreas derived from intraductal papillary adenocarcinoma in a resectable state.
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Ariizumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hatori
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Imaizumi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shin
authors.initials: S
authors.lastname: Akimoto
authors.forename: Ken
authors.initials: K
authors.lastname: Takasaki
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000473:pathology*; D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D016577:Pancreaticoduodenectomy; D010195:Pancreatitis / Q000150:complications
chemical_list: D018395:CA-19-9 Antigen