[Cyclic nucleotides phosphodiesterase activity in a rat lung model of asthma]
OBJECTIVE: To assess the change of cGMP-PDE and cAMP-PDE activity in a rat lung model of asthma. METHODS: cGMP-PDE and cAMP-PDE activity were determined by HPLC. RESULTS: Both cAMP-PDE activity and cGMP-PDE activity in the lung tissue of antigen-challenged rats were higher than that from the normal rats (P <0.05). CONCLUSION: In the rat lung model of asthma, cyclic nucleotides phosphodiesterase activity was elevated. This may be significant in the pathogenesis of asthma.
Song
Yan-Hua
YH
College of Medical Science, Zhejiang University, Hangzhou 310031, China.
Chen
Ji-Qiang
JQ
Zhou
Han-Liang
HL