Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology.
One of the fundamental molecules governing the survival of mammalian cells is oxygen. Oxygen has gained particular significance in tumor developmental biology and oncology. An increasingly diverse array of methods is now available to characterize tumor oxygenation. This Prospect will consider a new method, Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping (FREDOM), which we have recently developed for oximetry, examine application to a specific therapeutic example and place this technique in the context of other approaches.
Mason
Ralph P
RP
Department of Radiology, U.T. Southwestern Medical Center, Dallas, Texas, USA. Ralph.Mason@UTSouthwestern.edu
Ran
Sophia
S
Thorpe
Philip E
PE
D000280:Administration, Inhalation; D000818:Animals; D017352:Echo-Planar Imaging / Q000379:methods*; D005466:Fluorocarbons; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D011379:Prognosis; D013997:Time Factors; D014407:Tumor Cells, Cultured
D005466:Fluorocarbons; C003005:hexafluorobenzene; D010100:Oxygen