Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.
Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.
Nagai
Akiko
A
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Obihiro, Hokkaido 080-8555, Japan.
Yokoyama
Naoaki
N
Matsuo
Tomohide
T
Bork
Sabine
S
Hirata
Haruyuki
H
Xuan
Xuenan
X
Zhu
Yinchang
Y
Claveria
Florencia G
FG
Fujisaki
Kozo
K
Igarashi
Ikuo
I
D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D001403:Babesia / Q000187:drug effects* / Q000254:growth & development; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D011739:Pyrimethamine / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000634:Aminoquinolines; D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C004331:pamaquine; D011739:Pyrimethamine