title: Antimicrobial activity of broad-spectrum agents tested against Gram-negative bacilli resistant to ceftazidime: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001).
abstract: To assess the effect of ceftazidime resistance on the activity of other antimicrobial agents, 4,175 Gram-negative bacilli isolates, designated as ceftazidime-susceptible (3,759, 90%) or -resistant (416, 10%) were tested against a panel of nine agents. Cefepime was the most active of the agents tested, against both ceftazidime-susceptible and -resistant isolates, with a particularly low incidence (0.3%, 10/3152 isolates) of resistance among the Enterobacteriaceae. Tobramycin had the best activity against Pseudomonas aeruginosa and ticarcillin/clavulanate was the least active of the tested agents. This study confirms the need for constant monitoring of in vitro antimicrobial efficacy to direct empiric treatment regimens.
authors.affiliation: The JONES Group/JMI Laboratories, North Liberty, IA, USA. ronald-jones@jmilabs.com
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: David J
authors.initials: DJ
authors.lastname: Varnam
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime