[Ability of energy metabolism of cells to activate repair of its genetic material after radiation damage].
A new hypothesis on a mechanism of action of the radioprotective and medical preparations involving the activation of oxidative phosphorylation and biogenesis of mitochondria which provides the increase of dimension and rapidity of the cellular reparation has been suggested. A previously unknown property of mitochondrions to determine a cellular homeostasis has been found. An activation of oxidative phosphorylation of mitochondria is a way of cellular protection against extreme conditions (namely, against radiation exposure and tumor formation).
Kozyreva
E V
EV
Institute for General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315 Russia.
Eliseenko
N N
NN
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D004260:DNA Repair; D004734:Energy Metabolism; D006168:Guinea Pigs; D022781:Hepatocytes / Q000187:drug effects / Q000528:radiation effects; D006706:Homeostasis; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D010085:Oxidative Phosphorylation; D011832:Radiation Injuries / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects
D000244:Adenosine Diphosphate