title: Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control study.
abstract: In a population-based case-control study among adults in Italy, of 261 lymphoid and 313 myeloid leukaemias and 1718 controls, a later age at adenoidectomy and tonsillectomy (after age 10 years) increased considerably the risk of lymphocytic (but not myeloid) leukaemia (odds ratio 4.2, 95% confidence interval 1.1-16.2). We propose that late infection is a proliferative stimulus for B-cells.
authors.affiliation: Servizio di Epidemiologia dei Tumori, Ospedale S. Giovanni Battista e Università di Torino, Italy. paolo.vineis@unito.it
authors.forename: P
authors.initials: P
authors.lastname: Vineis
authors.forename: L
authors.initials: L
authors.lastname: Miligi
authors.forename: P
authors.initials: P
authors.lastname: Crosignani
authors.forename: L
authors.initials: L
authors.lastname: Davico
authors.forename: A
authors.initials: A
authors.lastname: Fontana
authors.forename: G
authors.initials: G
authors.lastname: Masala
authors.forename: O
authors.initials: O
authors.lastname: Nanni
authors.forename: V
authors.initials: V
authors.lastname: Ramazzotti
authors.forename: S
authors.initials: S
authors.lastname: Rodella
authors.forename: E
authors.initials: E
authors.lastname: Stagnaro
authors.forename: R
authors.initials: R
authors.lastname: Tumino
authors.forename: C
authors.initials: C
authors.lastname: Viganò
authors.forename: C
authors.initials: C
authors.lastname: Vindigni
authors.forename: A S
authors.initials: AS
authors.lastname: Costantini
mesh_terms: D000233:Adenoidectomy / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002455:Cell Division; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D011183:Postoperative Complications / Q000821:virology*; D014068:Tonsillectomy / Q000009:adverse effects*