title: A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes.
abstract: Glucagon-like peptide 1 (GLP-1), an insulinotropic hormone normally synthesised in the intestinal mucosa and released in response to a meal, is essential for normal glucose homoeostasis. There is much interest in the use of GLP-1 to treat diabetes, since the risk of hypoglycaemia is thought to be low. We report an instance of a 45-year-old woman with a GLP-1 and somatostatin secreting neuroendocrine tumour who presented with reactive hypoglycaemia and hyperglycaemia, but who was subsequently cured by surgery. This case, of a neuroendocrine tumour secreting GLP-1 and causing reactive hypoglycaemia, indicates a potential adverse effect of GLP-1 therapy for diabetes.
authors.affiliation: Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, W12 ONN, London, UK. jeanie.todd@ic.ac.uk
authors.forename: J F
authors.initials: JF
authors.lastname: Todd
authors.forename: S A
authors.initials: SA
authors.lastname: Stanley
authors.forename: C A
authors.initials: CA
authors.lastname: Roufosse
authors.forename: A E
authors.initials: AE
authors.lastname: Bishop
authors.forename: B
authors.initials: B
authors.lastname: Khoo
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
authors.forename: K
authors.initials: K
authors.lastname: Meeran
mesh_terms: D001786:Blood Glucose; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D048909:Diabetes Complications; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1; D005951:Glucose Tolerance Test; D006801:Humans; D007003:Hypoglycemia / Q000150:complications; D007044:Hysterectomy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010446:Peptide Fragments / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D010446:Peptide Fragments; D011498:Protein Precursors; D013004:Somatostatin; D052216:Glucagon-Like Peptide 1; D005934:Glucagon