title: [Comparative study of post-infarction myocardial viability after fibrinolysis by stress tomoscintigraphy and echography: can viability be detected without ischemia?].
abstract: The objectives of this prospective study was to define the comparative ability of stress myocardial scintigraphy and dobutamine stress echocardiography to demonstrate post-MI myocardial viability, assessed on the functional recovery in terms of improvement of global and segmental kinetics by cardiac gamma-angiography after revascularization. 18 patients (11 anterior MI, 7 lateral or inferior MI) and 162 segments were analysed semiquantitatively. All patients with persistent significant stenosis underwent secondary revascularization of the artery responsible for myocardial infarction. The prevalence of viability was high, as only 34% of segments initially presented a segmental kinetic abnormality and contraction was improved at 6 months in 54% of cases. Stress scintigraphy and dobutamine echocardiography detected viability with a sensitivity of 96% and 70%, a specificity of 88% and 82%, a positive predictive value of 89% and 77% and a negative predictive value of 95% and 76%, respectively. Only the wall score index with low-dose dobutamine was correlated with the ejection fraction at 6 months. Stress echocardiography is a more reliable predictor of the degree of functional recovery after revascularization. Scintigraphy visualizes much more extensive abnormalities than echocardiography. This often corresponds to ischaemic territories with normal contraction under baseline conditions and low doses of dobutamine. It therefore seems preferable both examinations for optimal assessment of thrombolized patients following myocardial infarction.
authors.affiliation: Service de Médecine Nucléaire et Ultrasons, CHU Trousseau, 37044 Tours.
authors.forename: V
authors.initials: V
authors.lastname: Eder
authors.forename: A
authors.initials: A
authors.lastname: Sirinelli
authors.forename: C
authors.initials: C
authors.lastname: Marchal
authors.forename: D
authors.initials: D
authors.lastname: Casset-Senon
authors.forename: P
authors.initials: P
authors.lastname: Pescher
authors.forename: F
authors.initials: F
authors.lastname: Tranquart
authors.forename: J M
authors.initials: JM
authors.lastname: Pottier
authors.forename: B
authors.initials: B
authors.lastname: Charbonnier
mesh_terms: D000328:Adult; D000368:Aged; D000790:Angiocardiography / Q000592:standards; D002316:Cardiotonic Agents; D017023:Coronary Angiography / Q000592:standards; D004280:Dobutamine; D004452:Echocardiography / Q000592:standards*; D005080:Exercise Test / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000592:standards*; D020127:Recovery of Function; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D013794:Thallium Radioisotopes; D004280:Dobutamine