title: Cross-species sequence comparisons: a review of methods and available resources.
abstract: With the availability of whole-genome sequences for an increasing number of species, we are now faced with the challenge of decoding the information contained within these DNA sequences. Comparative analysis of DNA sequences from multiple species at varying evolutionary distances is a powerful approach for identifying coding and functional noncoding sequences, as well as sequences that are unique for a given organism. In this review, we outline the strategy for choosing DNA sequences from different species for comparative analyses and describe the methods used and the resources publicly available for these studies.
authors.affiliation: Perlegen Sciences, Mountain View, California 94043, USA. kelly_frazer@perlegen.com
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Frazer
authors.forename: Laura
authors.initials: L
authors.lastname: Elnitski
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Church
authors.forename: Inna
authors.initials: I
authors.lastname: Dubchak
authors.forename: Ross C
authors.initials: RC
authors.lastname: Hardison
mesh_terms: D000818:Animals; D001483:Base Sequence / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D004247:DNA / Q000235:genetics; D030561:Databases, Nucleic Acid / Q000600:supply & distribution*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004247:DNA