Synthesis of alkyl and aryl esters of N-protected beta-homoamino acids from N-protected alpha-aminodiazoketones.
A simple and concomitant esterification method for the synthesis of methyl, ethyl, t-butyl, benzyl, and 9-fluorenylmethyl esters of Fmoc-/Boc-/Z-beta-homoamino acids employing Fmoc-/Boc-/Z-alpha-aminodiazoketones by Wolff rearrangement is described. The method offers good yield with purity.
Vasanthakumar
G R
GR
Department of Studies in Chemistry, Central College Campus, Dr B R Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India.
Gopi
H N
HN
Suresh Babu
V V
VV
D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*
D000596:Amino Acids; D004952:Esters; D007659:Ketones