title: In vivo test of pressure head and flow rate estimation in a continuous-flow artificial heart.
abstract: To avoid using sensors with low biocompatibility and low durability in implantable total artificial heart (TAH) systems, the authors previously proposed a new method for estimating instantaneous values of flow rate and pressure head on the basis of voltage, current, and rotational speed in a motor driven centrifugal pump. The previous in vitro experiments showed that the proposed estimator could automatically compensate for the effect of the change in blood viscosity on the estimation accuracy by employing two kinds of autoregressive exogenous models. In this study, validity and reliability of this estimation method were ascertained in an acute animal experiment. In the experiment, two centrifugal blood pumps were implanted into an adult goat as a total artificial heart. Results of estimation were compared with true values when blood viscosity was changed by injecting physiological saline. The results indicated that the system could successfully estimate pressure head by compensating the change of viscosity, although the estimation accuracy of the in vivo estimation was not so high as that of the previous in vitro tests.
authors.affiliation: Department of Electrical and Communication Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan. a-tanaka@ieee.org
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nitta
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001809:Blood Viscosity / Q000502:physiology; D002498:Centrifugation; D003326:Coronary Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D006041:Goats; D006331:Heart Diseases / Q000503:physiopathology* / Q000601:surgery*; D006354:Heart, Artificial; D018056:Hemorheology; D015203:Reproducibility of Results; D013223:Statistics as Topic