Catalog of 668 SNPs detected among 31 genes encoding potential drug targets on the cell surface.
We have been publishing a series of detailed maps of single-nucleotide polymorphisms (SNPs) detected within the genomic loci of 145 genes encoding drug-metabolizing enzymes and transporters. As an addition to the maps reported earlier, we provide here high-density SNP maps of 31 genes encoding various receptors and adhesion molecules of medical importance. By examining a total of approximately 382 kb of genomic DNA encompassing these 31 genes, we identified 668 SNPs among 48 healthy Japanese individuals: 86 in 5' flanking regions, 27 in 5' untranslated regions, 45 in coding regions, 399 in introns, 47 in 3' untranslated regions, and 64 in 3' flanking regions. We also discovered 113 variations of other types. Of the 668 SNPs, 371 (55.5%) appeared to be novel, on the basis of comparisons with the dbSNP database of the National Center for Biotechnology Information (US) or with previous publications. The maps constructed in this study will serve as an additional resource for studies of complex genetic diseases and drug-response phenotypes to be mapped by linkage-disequilibrium analyses.
Iida
Aritoshi
A
Laboratory for Genotyping, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, Yokohama, Japan.
Saito
Susumu
S
Sekine
Akihiro
A
Mishima
Chihiro
C
Kitamura
Yuri
Y
Kondo
Kimie
K
Harigae
Satoko
S
Osawa
Saori
S
Nakamura
Yusuke
Y
D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011955:Receptors, Drug / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
D015815:Cell Adhesion Molecules; D011955:Receptors, Drug