Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
OBJECTIVE
To observe the effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury (TBI).


METHODS
An acute experimental closed TBI model in rats was induced by a fluid-percussion brain injury model. At five and sixty minutes after TBI, the animals were intraperitoneally injected by ganglioside GM1 (30 mg/kg) or the same volume of saline. At the 6th hour after TBI, effects of ganglioside GM1 or saline on changes of mean arterial pressure (MAP), contents of water, lactic acid (LA) and lipid peroxidation (LPO) in the injured cerebral tissues were observed.


RESULTS
After TBI, MAP decreased and contents of water, LA and LPO increased in brain injury group; however, MAP was back to normal levels and contents of water, LA and LPO decreased in ganglioside GM1 treated group, compared with those in brain injury group (P < 0.05). No significant difference between the saline treated group and the brain injury group (P > 0.05) was observed.


CONCLUSIONS
Ganglioside GM1 does have obvious neuroprotective effect on early TBI.
Chen
Zhi-gang
ZG
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai Institute of Neurosurgery, Shanghai 200003, China. zhigchen@yahoo.com
Lu
Yi-cheng
YC
Zhu
Cheng
C
Zhang
Guang-ji
GJ
Ding
Xue-hua
XH
Jiang
Ji-yao
JY
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism*; D004195:Disease Models, Animal; D006602:Hexosyltransferases / Q000627:therapeutic use*; D019344:Lactic Acid / Q000032:analysis; D015227:Lipid Peroxidation; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D019344:Lactic Acid; C014866:G(M1)ganglioside synthetase; D006602:Hexosyltransferases