N-CAM expression and localization in PC12 cells modulated by extracellular peptides.
The neural cell adhesion molecules (N-CAMs) play an important role in mediating cell-cell interactions in the nervous system. Different isoforms of these membrane proteins are involved in the formation of the neuronal network and in the dynamic phases of neuronal plasticity. We studied the early stages of the pseudo neuronal differentiation of PC12 cells induced by a class of small acidic peptides capable of modulating gene expression in these cells. The data presented here indicate that peptides with specific sequences induce an increase in N-CAM mRNA expression and protein translocation to the plasma membrane to a comparable degree as NGF.
Mariggiò
Maria A
MA
Dipartimento di Scienze del Farmaco, Laboratorio di Fisiologia Cellulare, Università G. d'Annunzio, 66013 Chieti, Italy. mariggio@unich.it
Guarnieri
Simone
S
Mariggiò
Stefania
S
Morabito
Caterina
C
Gianfranceschi
Gian Luigi
GL
Fanò
Giorgio
G
D000818:Animals; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D016716:PC12 Cells; D010455:Peptides / Q000378:metabolism*; D051381:Rats
D019006:Neural Cell Adhesion Molecules; D010455:Peptides