Adult outcome of social function in adolescent-onset schizophrenia and affective psychosis.
OBJECTIVE
To examine and compare the adult outcome in a representative sample of hospitalized adolescent-onset psychoses including occupational and social aspects.


METHODS
A total of 81 patients with a first episode of early-onset psychosis (before age 19 years) presenting to the University Hospital of Lund, Sweden, between 1982 and 1993 were followed up an average of 10.5 years (range 5.1-18.2) after admission. Initial diagnosis was assessed from records and consisted of DSM-IV schizophrenia (n = 32), schizoaffective disorder (n = 7), bipolar disorder (n = 25), and major depressive disorder with psychotic features (n = 17). All could be traced and assigned a major outcome group.


RESULTS
Early-onset schizophrenia spectrum disorder suffered a chronic course with a poor outcome in 79% of the cases, while early-onset affective psychosis in 74% showed a good or intermediate outcome. The poor outcome (26%) in the affective group was connected to mental retardation in 7% and to progression to a schizoaffective disorder in 12%. A particularly severe outcome was seen for schizophrenia spectrum patients with a family history of nonaffective psychosis.


CONCLUSIONS
Early-onset schizophrenia spectrum disorder showed a severe course while affective psychoses had a much more benign functional outcome.
Jarbin
Hakan
H
Department of Child and Adolescent Psychiatry, University Hospital, Uppsala, Sweden. hakan.jarbin@psykiatr.lu.se
Ott
Yngve
Y
Von Knorring
Anne-Liis
AL
D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D019964:Mood Disorders / Q000150:complications* / Q000523:psychology*; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology*; D012559:Schizophrenia / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D012919:Social Behavior