[Epstein-Barr virus and Hodgkin's lymphoma].
The suspicion that Hodgkin's lymphoma, previously known as Hodgkin's disease, may have an infectious etiology has existed for many years. The assumption rests on epidemiological characteristics, in particular a strong correlation between socio-economic status and risk of Hodgkin's lymphoma in young adults, as well as both serological and molecular biological evidence that the Epstein-Barr virus is involved in the development of up to 50% of all cases of Hodgkin's lymphoma. We present the current epidemiological, serological and molecular biological evidence for an infectious etiology to Hodgkin's lymphoma with emphasis on the association with Epstein-Barr virus.
Hjalgrim
Henrik
H
Afdeling for Epidemiologisk Forskning, Statens Serum Institut, DK-2300 København S. hhj@ssi.dk
Munksgaard
Lars
L
Melbye
Mads
M
D000328:Adult; D015984:Causality; D002648:Child; D015897:Comorbidity; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D015994:Incidence; D008297:Male; D012307:Risk Factors; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D012959:Socioeconomic Factors