Combination assay of urinary free L-fucose and trypsin inhibitor may be useful indicators of disease activity in patients with hematologic malignancies.
L-Fucose is a monosaccharide located at the non-reducing ends of sugar chains of glycoconjugates. Urinary L-fucose (U-FC) is excreted as free L-fucose, and clinically useful as a tumor marker of digestive organ cancers. We evaluated the clinical usefulness of U-FC levels in patients with various hematologic malignancies because U-FC for hematologic malignancies has only rarely been described. The mean U-FC levels in the acute nonlymphocytic leukemia (ANLL), myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD) groups were significantly higher than in the control group (P < 0.05). Recently, we reported that urinary trypsin inhibitor (UTI) levels in patients with ANLL, MDS, non-Hodgkin's lymphoma and multiple myeloma were significantly elevated, compared with those in healthy adult volunteers. Noninvasive combination assays of UTI and U-FC may have a higher accuracy in diagnosis of ANLL and MDS than those of UTI or U-FC alone. UTI and U-FC combination assays, noninvasive for patients, could be expanded as useful indicators in hematologic malignancies.
Takubo
Takayuki
T
Aoyama
Yasutaka
Y
Nakamae
Hirohisa
H
Tanaka
Kazuo
K
Ohta
Kensuke
K
Yamane
Takahisa
T
Hino
Masayuki
M
D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D019411:Clinical Laboratory Techniques; D005643:Fucose / Q000652:urine*; D019337:Hematologic Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D014361:Trypsin Inhibitors / Q000652:urine*
D015415:Biomarkers; D014361:Trypsin Inhibitors; D005643:Fucose