Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication.
Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIV(mac)239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.
Mothé
Bianca R
BR
Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715-1299, USA.
Weinfurter
Jason
J
Wang
Chenxi
C
Rehrauer
William
W
Wilson
Nancy
N
Allen
Todd M
TM
Allison
David B
DB
Watkins
David I
DI
D000483:Alleles; D000818:Animals; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008253:Macaca mulatta; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D019562:Viral Load; D014779:Virus Replication / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; C110764:Mamu-A 01 antigen; D012367:RNA, Viral