title: Correlation of urinary 1-hydroxypyrene and 2-naphthol with total suspended particulates in ambient air in municipal middle-school students in Korea.
abstract: The authors investigated Korean municipal middle school students to ascertain whether urinary 1-hydroxypyrene (1-OHP) and 2-naphthol-markers for polycyclic aromatic hydrocarbon (PAH) exposure-reflect PAHs in ambient air. The authors used the beta-ray absorption method, which is an index of ambient-air PAH exposure, to collect total suspended particulate (TSP) data. The authors measured urinary 1-OHP and 2-naphthol concentrations in 137 nonsmoking students in 4 municipal middle schools within 1 km of ambient air monitoring stations. The median concentrations of urinary 1-OHP and 2-naphthol in the study were 0.09 nmole/mol creatinine and 2.19 micromol/mol creatinine, respectively, and the geometric means were 0.10 nmole/mol creatinine and 2.47 micromol/mol creatinine, respectively. Urinary 1-OHP concentration did not correlate significantly with any TSP index. There were significant correlations between urinary 2-naphthol level and the daily mean TSP level calculated for 2 days before survey, for 1 day before survey, and for the day of survey. These data suggest that urinary 2-naphthol may be a good marker for inhalation exposure to PAHs in ambient air.
authors.affiliation: Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea.
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Kang
authors.forename: Soo-Hun
authors.initials: SH
authors.lastname: Cho
authors.forename: Heon
authors.initials: H
authors.lastname: Kim
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002648:Child; D005260:Female; D006306:Health Surveys; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D009153:Mutagens / Q000032:analysis*; D009284:Naphthols / Q000652:urine*; D010316:Particle Size; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects* / Q000032:analysis; D011721:Pyrenes / Q000032:analysis*; D012044:Regression Analysis; D013334:Students; D016482:Urinalysis
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D009153:Mutagens; D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C033146:1-hydroxypyrene; C028405:2-naphthol