title: (-)-Axinyssene: a novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp.
abstract: [structure: see text] A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5',9'-dimethyl-1'-methylene-4',8'-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Kodama
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Rob W M
authors.initials: RW
authors.lastname: Van Soest
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D002455:Cell Division / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013057:Spectrum Analysis; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D004224:Diterpenes; C474724:axinyssene