title: The use of pH to influence regio- and chemoselectivity in the asymmetric aminohydroxylation of styrenes.
abstract: [reaction: see text] The pH-controlled Sharpless asymmetric aminohydroxylation (AA) of styrenes provides 1-aryl-2-amino ethanols (regioisomer B) with high enantio-, chemo-, and regioselectivity. As existing AA protocols typically give regioisomer A as the major reaction product when using carbamate nitrogen sources, this method is a convenient alternative for the selective production of regioisomer B.
authors.affiliation: Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
authors.forename: Vitaliy
authors.initials: V
authors.lastname: Nesterenko
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Byers
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hergenrother