title: In vitro response of mitochondrial succinate oxidase system to epinephrine in human blood lymphocytes from health individuals and patients with neurocirculatory dystonia.
abstract: Activities of succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (hyaloplasmic and mitochondrial: alpha-GPDHH and alpha-GPDHM) in peripheral blood lymphocytes, and the response of SDH activity to exogenous epinephrine in vitro (the epinephrine test) were studied in 20 healthy subjects and 46 patients with hypertensive neurocirculatory dystonia. Activities of SDH, alpha-GPDHH, and alpha-GPDHM in blood lymphocytes and SDH adrenoreactivity in epinephrine test were higher in patients than in healthy controls. Treatment with hypotensive agents (isradipin and pyrroxan) moderated adrenoreactivity. Phytotherapy normalized the baseline activities of succinate oxidase system and alpha-glycerophosphate pathway in blood lymphocytes.
authors.affiliation: State Research Institute of Military Medicine, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.forename: L V
authors.initials: LV
authors.lastname: Koroleva
authors.forename: I A
authors.initials: IA
authors.lastname: Lairov
authors.forename: S N
authors.initials: SN
authors.lastname: Radchenko
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004146:Dioxanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D004837:Epinephrine / Q000494:pharmacology*; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood; D006801:Humans; D017275:Isradipine / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D009449:Neurocirculatory Asthenia / Q000201:enzymology*; D010088:Oxidoreductases / Q000097:blood*; D013385:Succinate Dehydrogenase / Q000097:blood; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D004146:Dioxanes; D010088:Oxidoreductases; C022691:succinate oxidase; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; C009143:proroxan; D004837:Epinephrine; D017275:Isradipine