Canine model of nasal congestion and allergic rhinitis.
The ragweed- and histamine-induced decreases in nasal patency in cohorts of ragweed-sensitized and nonsensitized dogs were assessed. The volume of nasal airways (V(NA)) was assessed by acoustic rhinometry and resistance to airflow (R(NA)) by anterior rhinomanometry. Histamine delivered to the nasal passages of five dogs caused a rapid and prolonged increase in R(NA) (0.75 +/- 0.26 to 3.56 +/- 0.50 cmH(2)O. l(-1). min), an effect that was reversed by intranasal delivery of aerosolized phenylephrine. Ragweed challenge in five ragweed-sensitized dogs increased R(NA) from 0.16 +/- 0.02 to 0.53 +/- 0.07 cmH(2)O. l(-1). min and decreased V(NA) from 12.5 +/- 1.9 to 3.9 +/- 0.3 cm(3), whereas administration of saline aerosol neither increased R(NA) nor decreased V(NA). Prior administration of d-pseudoephedrine (30 mg po) attenuated the ragweed-induced increase in R(NA) and decrease in V(NA). Ragweed challenge changed neither R(NA) nor V(NA) in four nonsensitized dogs. Mediator-induced nasal congestion and allergen-induced allergic rhinitis in ragweed-sensitized dogs, which exhibit symptoms similar to human disease, can be used in the evaluation of safety and efficacy of antiallergic activity of potential drugs.
Tiniakov
Ruslan L
RL
University of Illinois at Chicago, and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612, USA.
Tiniakova
Olga P
OP
McLeod
Robbie L
RL
Hey
John A
JA
Yeates
Donovan B
DB
D000336:Aerosols; D000403:Airway Resistance / Q000502:physiology; D031164:Ambrosia / Q000276:immunology; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006632:Histamine / Q000494:pharmacology; D008297:Male; D014663:Nasal Decongestants / Q000627:therapeutic use; D015508:Nasal Obstruction / Q000188:drug therapy / Q000503:physiopathology*; D011058:Pollen / Q000276:immunology; D015656:Respiratory Mechanics / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000503:physiopathology*; D025363:Rhinomanometry
D000336:Aerosols; D014663:Nasal Decongestants; D006632:Histamine