title: Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin A hybrid peptide.
abstract: Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.
authors.affiliation: Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, Division of Clinical Virology, F-68, Huddinge University Hospital, S-14186 Huddinge, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Wade
authors.forename: Jan-Ingmar
authors.initials: JI
authors.lastname: Flock
authors.forename: Charlotta
authors.initials: C
authors.lastname: Edlund
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Löfving-Arvholm
authors.forename: Matti
authors.initials: M
authors.lastname: Sällberg
authors.forename: Tomas
authors.initials: T
authors.lastname: Bergman
authors.forename: Angela
authors.initials: A
authors.lastname: Silveira
authors.forename: Cecille
authors.initials: C
authors.lastname: Unson
authors.forename: Louise
authors.initials: L
authors.lastname: Rollins-Smith
authors.forename: Jerzy
authors.initials: J
authors.lastname: Silberring
authors.forename: Malcom
authors.initials: M
authors.lastname: Richardson
authors.forename: Pentti
authors.initials: P
authors.lastname: Kuusela
authors.forename: Hilkka
authors.initials: H
authors.lastname: Lankinen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D011506:Proteins; D011993:Recombinant Fusion Proteins; C104501:temporin; C031161:cecropin A