Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults.
Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.
Muller
Claude P
CP
Department of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, PO Box 1102, 20A rue Auguste Lumière, L-1950, Luxembourg, Luxembourg. claude.muller@lns.etat.lu
Marquet-Blouin
Estelle
E
Fack
Fred
F
Damien
Benjamin
B
Steinmetz
Andŕe
A
Bouche
Fabienne B
FB
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D022462:Vaccines, Edible / Q000008:administration & dosage / Q000276:immunology
D000956:Antigens, Viral; D008458:Measles Vaccine; D022462:Vaccines, Edible