[Gly40Ser mutation of glucagon receptor gene and NIDDM in Han nationality].
OBJECTIVE
To ascertain whether Gly40Ser mutation in exon 2 of glucagon receptor (GCG-R) gene is associated with late-onset non-insulin-dependent diabetes millitus (NIDDM) in Chinese.


METHODS
We selected 82 NIDDM patients and 136 controls of Han nationality in Hunan province, and detected Gly40Ser mutation using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
None of Gly40Ser mutation was found in all subjects.


CONCLUSIONS
The mutation doesn't associate with NIDDM in Chinese, even though the mutation was reported to be associated with NIDDM in certain French and Caucasians, genetic heterogeneity of NIDDM among ethnic groups should be considered.
Deng
H
H
National Lab of Medical Genetics of China, Central South University, Changsha 410078, China.
Tang
W L
WL
Pan
Q
Q
D000293:Adolescent; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018027:Receptors, Glucagon / Q000235:genetics*
D018027:Receptors, Glucagon