title: [Allele-specific chromosome 9p deletion in oral cancer].
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between loss of heterozygosity (LOH) on chromosome 9p and the pathogenesis of oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  A total of 24 human OSCC specimens were analyzed for LOH on chromosome 9p using 8 microsatellite markers by means of polymerase chain reaction.
  
  
  RESULTS
  In 24 cases of OSCC, LOH on chromosome 9p was identified in 10 of 24 cases (41.67%) with at least one marker. The main LOH were found on 9p21 at locus D9S171 (21.05%) and D9S304 (10.00%). There were also a deletion on 9p22-23 at locus D9S168 (22.22%) and D9S162 (15.38%). However, there was no statistically significant correlation between LOH at these loci with such clinical parameters as pathological types, tumor size and lymph-node metastasis. Microsatellite instability (MSI) is rare for any of the 8 markers in 24 OSCC. No MSI could observed using the common criteria for defining MSI-its detection in two or more markers.
  
  
  CONCLUSIONS
  We found that high frequency of LOH occurred at 9p21-23 band. Their results indicate that more than one tumor suppressor genes at chromosome 9p21-23 region related to a subset of OSCC, while MSI might not be a crucial event.
authors.affiliation: Cancer Center, First Affiliated Hospital, West China University of Medical Sciences.
authors.forename: L
authors.initials: L
authors.lastname: Xiao
authors.forename: I O
authors.initials: IO
authors.lastname: Ng
authors.forename: Z C
authors.initials: ZC
authors.lastname: Luo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics*