title: A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network.
abstract: Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA. rao@wubios.wustl.edu
authors.forename: Dabeeru C
authors.initials: DC
authors.lastname: Rao
authors.forename: Michael A
authors.initials: MA
authors.lastname: Province
authors.forename: Mark F
authors.initials: MF
authors.lastname: Leppert
authors.forename: A l
authors.initials: Al
authors.lastname: Oberman
authors.forename: Gerardo
authors.initials: G
authors.lastname: Heiss
authors.forename: R Curt
authors.initials: RC
authors.lastname: Ellison
authors.forename: Donna K
authors.initials: DK
authors.lastname: Arnett
authors.forename: John H
authors.initials: JH
authors.lastname: Eckfeldt
authors.forename: Karen
authors.initials: K
authors.lastname: Schwander
authors.forename: Steve C
authors.initials: SC
authors.lastname: Mockrin
authors.forename: Steve C
authors.initials: SC
authors.lastname: Hunt
mesh_terms: D001741:Black or African American; D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D019992:Databases as Topic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006078:Government Programs; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008126:Lod Score; D009316:National Institutes of Health (U.S.); D035781:Siblings; D016615:Telomere; D014481:United States; D044465:White People / Q000235:genetics*