title: Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.
abstract: [reaction: see text] Described are the syntheses of eight macrocyclic peptides designed to trap Holliday junctions in bacteria, thereby inhibiting bacterial growth. These macrocycles were designed from linear dimerized hexapeptides that bind to the C-2 symmetrical Holliday junction. They were synthesized from three monomers using a combinatorial-like strategy that permits elucidation of the monomer role in accumulation of Holliday junctions and antibiotic activity. These macrocycles are an important step in designing and synthesizing a new class of antibiotics.
authors.affiliation: Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Drive, 208 CSL, San Diego State University, San Diego, California 92182-1030, USA.
authors.forename: Megan L
authors.initials: ML
authors.lastname: Bolla
authors.forename: Enrique V
authors.initials: EV
authors.lastname: Azevedo
authors.forename: Jason M
authors.initials: JM
authors.lastname: Smith
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Taylor
authors.forename: Dev K
authors.initials: DK
authors.lastname: Ranjit
authors.forename: Anca M
authors.initials: AM
authors.lastname: Segall
authors.forename: Shelli R
authors.initials: SR
authors.lastname: McAlpine
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors*; D004274:DNA, Recombinant; D015195:Drug Design; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004274:DNA, Recombinant; D010456:Peptides, Cyclic