[The prognostic value of vascular endothelial growth factor in breast cancer].
OBJECTIVE
To define the relevance of VEGF status to the prognosis of breast cancer.


METHODS
The tissues of 70 invasive ductal breast carcinomas were evaluated for VEGF protein expression by immunohistochemistry LSAB method, and the prognostic value of VEGF status was assessed in combination with the follow-up data on those breast cancer patients.


RESULTS
VEGF status was inversely correlated with relapse-free survival and overall survival. Kaplan-Merier survival curve showed that VEGF-rich tumor group had higher relapse rate and mortality rate. Multivariate regression analysis confirmed that the VEGF status had certain prognostic value, but it could not be considered as an independent prognostic indicator.


CONCLUSIONS
VEGF status is one of the significant prognostic indicators of breast cancer.
Jing
J
J
Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Zhao
Y
Y
Li
H
H
Zhang
S
S
Shi
Z
Z
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry*; D016228:Endothelial Growth Factors / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis*; D008222:Lymphokines / Q000032:analysis*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D014408:Biomarkers, Tumor; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors