title: Hematologic malignancies and Klinefelter syndrome. a chance association?
abstract: Klinefelter syndrome was first described in 1942 as an endocrine disorder characterized by gynecomastia, hypogonadism, small testes, and elevated levels of follicle-stimulating hormone. An extra X chromosome (i.e., 47,XXY) was subsequently demonstrated in these patients and an increased incidence of leukemia and lymphoma has been described. We report a retrospective study of a series of unselected patients with Klinefelter syndrome diagnosed by cytogenetic studies and the occurrence of hematologic malignancies. The literature is also reviewed.
authors.affiliation: Section of Hematology-Oncology, Comprehensive Cancer Center of Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157-1082, USA. ykeung@wfubmc.edu
authors.forename: Yi-Kong
authors.initials: YK
authors.lastname: Keung
authors.forename: David
authors.initials: D
authors.lastname: Buss
authors.forename: Allen
authors.initials: A
authors.lastname: Chauvenet
authors.forename: Mark
authors.initials: M
authors.lastname: Pettenati
mesh_terms: D000328:Adult; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics*; D007938:Leukemia / Q000453:epidemiology / Q000235:genetics*; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D012189:Retrospective Studies