[Biological characters of adenoid cystic carcinoma cells transduced with HSV-tk gene].
OBJECTIVE
To study the effects of herpes simplex virus thymidine kinase(HSV-tk) gene transduction on adenoid cystic carcinoma(ACC) cells.


METHODS
Gene transduced cells were detected with growth rate, scanning electronic microscope, transmission electronic microscope, cell cycle analysis and the expression of major histocompatibility complex(MHC) class I or II molecules.


RESULTS
The parameters detected in gene transduced cells and parental tumor cells were similar.


CONCLUSIONS
The HSV-tk gene transduction would not change the biological characters of tumor cells greatly.
Sun
C
C
Tumor Biology Laboratory, Department of Oral & Maxillofacial Surgery, Ninth Hospital, Shanghai Second Medical University.
He
R
R
Zhang
Z
Z
Liu
X
X
Zhou
S
S
Chen
S
S
D003528:Carcinoma, Adenoid Cystic / Q000276:immunology / Q000473:pathology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D012468:Salivary Gland Neoplasms / Q000276:immunology / Q000473:pathology*; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics*; D013937:Thymidine Kinase / Q000235:genetics*; D014161:Transduction, Genetic; D014407:Tumor Cells, Cultured
D013937:Thymidine Kinase