[Formation and characteristics of an artificial dermis--collagen-chondroitin-6-sulfate membrane].
In this study, we extracted type-I collagen from rat tail tendon with acetic acid and then mixed it with chondroitin-6-sulfate to form a collagen-chondroitin-6-sulfate membrane by freeze drying and crosslinking. The result showed that the collagen-chondroitin-6-sulfate membrane was semitransparent, with a network structure, and the pore size was about 100-150 microns. It was also demonstrated that the "dermis" achieved a good adherence to wound and the degradation rate in vitro was markedly decreased by glutaraldehyde crosslinkage.
Li
X
X
Guangzhou Red Cross Hospital, Guangzhou 510220.
Shi
J
J
D000818:Animals; D002809:Chondroitin Sulfates; D003094:Collagen / Q000302:isolation & purification; D020405:Dermis; D005612:Freeze Drying; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D051381:Rats; D017768:Skin, Artificial; D013623:Tail; D013710:Tendons / Q000737:chemistry
D008567:Membranes, Artificial; D002809:Chondroitin Sulfates; D003094:Collagen