[Image and quantity analysis of blood-gas in rabbit's artery and Na(+)-K(+)-ATPase in their lungs during PE-SWD treated by HFJV].
This study was made to gain an insight into the mechanism of high-frequency jet ventilation(HFJV) treatment for the pulmonary edema after seawater drowning(PE-SWD). PaO2, PaCO2 and oxygen saturation (SaO2) of the rabbit and Na(+)-K(+)-ATPase in the rabbit's lungs in three groups--PE-SWD group(PE-SWD-G), HFJV group (HFJV-G) and control group(CG), were measured and analysed by the blood-gas analyser and computer image system. The results showed that, after 100 minutes' HFJV, the PaO2, SaO2 and the activity of Na(+)-K(+)-ATPase in the lung capillary endothelial cells in HFJV-G were significantly higher than those in PE-SWD-G(P < 0.01 or P < 0.05). Three parameters of Na(+)-K(+)-TAPase(G1, D1 and D2) in HFJV-G almost returned to their values in CG. The authors suggest that the increase of PaO2 and SaO2 in the rabbit's artery blood in HFJV-G is closely related to the rehabilitation of Na(+)-K(+)-ATPase activity in the lungs after HFJV. The mechanism of successful HFJV treatment for PE-SWD is that HFJV can better correct hypoxemia and improve the rehabilitation of Na(+)-K(+)-ATPase activity in the rabbit's lungs.
Dong
M
M
Department of Pathology, Naval Medical College, Nanjing 210099.
Ding
Y
Y
Zhang
M
M
Luo
Y
Y
Wang
Y
Y
Liu
H
H
Dong
W
W
D000818:Animals; D001784:Blood Gas Analysis / Q000295:instrumentation; D004332:Drowning; D006611:High-Frequency Jet Ventilation; D007091:Image Processing, Computer-Assisted; D011654:Pulmonary Edema / Q000139:chemically induced / Q000628:therapy*; D011817:Rabbits; D012623:Seawater / Q000009:adverse effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D000254:Sodium-Potassium-Exchanging ATPase