title: [Immunologic histochemical observation of anti-crypt keratin of cryptic epithelium of tonsilla in children with chronic tonsillitis].
abstract: OBJECTIVE
  To investigate anti-crypt keratin (CK) immunologic histochemical changes in children with chronic tonsillitis.
  
  
  METHODS
  Removed tonsilla were fixed by 10% formaldehyde. Immunologic histochemical method was used to determine the changes of anti-broad spectrum (KD 68, 56, 56, 50) CKSP.
  
  
  RESULTS
  In 230 cases, obvious keratosis was 90.9%, no keratosis was 9.1%, 3 cases were found with fungus filaments and bacteria in the bottom of crypts. Anti-broad spectrum and hypermolecule CK of tonsil cryptic epithelium were positive reaction, anti-broad spectrum CK of cryptic keratosis in all cases was positive reaction.
  
  
  CONCLUSIONS
  During the period of episode, cryptic epitheliums of tonsilla was destroyed repeatly, therefore, immunoglobulin production was reduce. Because the immune function of tonsilla was reduced, bacteria and virus might be invade into organism. This reduplicative malignant circles must be interrupted or blocked only by tonsillectomy.
authors.affiliation: Department of Otorhinolaryngology, Wuhan Children's Hospital, Wuhan 430016.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Wang
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Xu
authors.forename: S F
authors.initials: SF
authors.lastname: Wang
authors.forename: J S
authors.initials: JS
authors.lastname: Lu
authors.forename: T
authors.initials: T
authors.lastname: Feng
authors.forename: J C
authors.initials: JC
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology*; D007642:Keratosis / Q000276:immunology; D008297:Male; D014066:Palatine Tonsil / Q000276:immunology; D014069:Tonsillitis / Q000276:immunology* / Q000473:pathology
chemical_list: D000906:Antibodies; D007633:Keratins