Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold.
The first fluorescent styryl dye library with a broad color range was synthesized by combinatorial condensation of various aldehydes and methyl pyridinium compounds, and their applications as organelle specific staining probes were demonstrated.
Rosania
Gustavo R
GR
Department of Chemistry, New York University, New York, New York 10003, USA. yt.chang@nyu.edu
Lee
Jae Wook
JW
Ding
Liang
L
Yoon
Hai-Shin
HS
Chang
Young-Tae
YT
D000447:Aldehydes / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics*; D006801:Humans; D008545:Melanoma / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D011726:Pyridinium Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D013343:Styrenes / Q000737:chemistry* / Q000493:pharmacokinetics*; D013347:Subcellular Fractions / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D005456:Fluorescent Dyes; D011726:Pyridinium Compounds; D013343:Styrenes