title: Ancistrolikokine D, a 5,8'-coupled naphthylisoquinoline alkaloid, and related natural products from Ancistrocladus likoko.
abstract: A new naphthylisoquinoline alkaloid, ancistrolikokine D, and the likewise 5,8'-coupled alkaloid ancistroealaine A, as well as two further, biosynthetically related, but nitrogen-free natural products, ancistronaphthoic acid B and cis-isoshinanolone, have been isolated from Ancistrocladus likoko J. LEACUTE;ONARD (Ancistrocladaceae). The 5,8'-coupling of the new alkaloids and of the alkaloids isolated earlier hints at a close phylogenetic relationship of A. likoko to other Central African Ancistrocladus species. The compounds show moderate activities against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei rhodesiense.
authors.affiliation: Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.forename: Wael
authors.initials: W
authors.lastname: Saeb
authors.forename: Markus
authors.initials: M
authors.lastname: Rückert
authors.forename: Jan
authors.initials: J
authors.lastname: Mies
authors.forename: Manuela
authors.initials: M
authors.lastname: Michel
authors.forename: Virima
authors.initials: V
authors.lastname: Mudogo
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029748:Caryophyllaceae / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015023:Democratic Republic of the Congo; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D014345:Trypanosoma / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D001688:Biological Products; D007546:Isoquinolines; D009281:Naphthalenes; D009284:Naphthols; C472946:ancistrolikokine D