[Experimental study on the biocompatibility and toxicology of interface between hydroxyapatite coating and bone].
According to "The standards for biological evaluation of bio-materials and bio-products abbreviated to STANDARDS" newly set by the Ministry of Health, PRC, 5 observation indexes were selected to evaluate systematically the biocompatibility and toxicology of China-made hydroxyapatite, which is clinicall used. The results revealed no effects of allergy, mutation and hemoclasis reaction except mild cytotoxicity. These indicate that the China-made hydroxyapatite meets the demand of STANDADS and thus may be clinically with safety.
Chen
Y
Y
Department of Plastic and Orthopaedics, 452th Hospital PLA, Chengdu 610061.
Zou
H
H
D020099:Coated Materials, Biocompatible / Q000633:toxicity*; D006882:Hydroxyapatites / Q000633:toxicity*; D008422:Materials Testing
D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites