Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients.
OBJECTIVE
To correlate the susceptibility of low-(LDL) and very-low-density lipoprotein to oxidation in vitro and the concentrations of serum antibodies against malondialdehyde-modified LDL and plasma vitamin E with the anthropometric and laboratory characteristics of obesity.


METHODS
A total of 75 nondiabetic, normotensive obese patients were assigned to one of four groups according to their body mass index (BMI): moderately obese (30 <or= BMI <or= 34.9 kg/m(2), n = 11), severely obese (35 <or= BMI <or= 39.9 kg/m(2), n = 20), morbidly obese (40 <or= BMI <or= 50 kg/m(2), n = 29), and very severely obese (BMI > 50 kg/m(2), n = 15).


RESULTS
The oxidation lag time for LDL from patients with a BMI >or=35 kg/m(2) was shorter than that for LDL from non-obese controls (n = 13), whereas very-low-density lipoprotein oxidation lag times were not significantly different. The serum antibodies against modified LDL were similar in all groups, whereas the plasma vitamin E concentrations of obese patients were decreased (p <or= 0.01). There was a negative correlation between LDL oxidation lag time and BMI (r = -0.35, p = 0.0008), and between plasma vitamin E and BMI (r = -0.53, p < 0.0001) and waist-to-hip ratio (r = -0.40, p = 0.0003).


CONCLUSIONS
The LDL of nondiabetic, normotensive obese patients is more readily oxidized, and plasma vitamin E concentrations are low. These are both risk factors for coronary heart disease.
Myara
Isaac
I
INSERM U 430, Broussais Hospital, and Claude Bernard Association, Paris, France.
Alamowitch
Catherine
C
Michel
Odile
O
Heudes
Didier
D
Bariety
Jean
J
Guy-Grand
Bernard
B
Chevalier
Jacques
J
D000328:Adult; D000428:Alcohol Drinking; D000906:Antibodies / Q000097:blood; D001824:Body Constitution; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000737:chemistry; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood / Q000276:immunology; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood*
D000906:Antibodies; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D014810:Vitamin E; D008315:Malondialdehyde; D003300:Copper; D002784:Cholesterol