Sequential elimination-cyclopropanation reactions promoted by samarium: highly diastereoselective synthesis of cyclopropylamides.
trans-Cyclopropanamides were obtained, in high yield, from 2-chloro-3-hydroxyamides by a sequenced elimination-cyclopropanation process promoted by Samarium/diiodomethane or Samarium diiodide and Samarium/diiodomethane.
Concellón
José M
JM
Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, Julián Clavería, 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es
Rodríguez-Solla
Humberto
H
Llavona
Ricardo
R