[Estrogenicity of trans-resveratrol in immature mice in vivo].
To investigate the estrogenicity of trans-resveratrol in vivo, different doses of trans-resveratrol were administered orally (ig.) or subcutaneously (s.c.) to the weanling mice for 4 d. The results showed that 2.0 mg/kg.b.w of trans-transveratrol (ig or s.c.) could shorten vaginal opening latency periods (P < 0.05) and enhance keratinization of vaginal epithelium dramatically, increase uterine wet weights and uterine-body weight ratios significantly (P < 0.05, P < 0.01). Additionally, trans-transveratrol could thicken the columnar epithelial cells or increase the numbers of glands in uterine in immature mice. It was concluded that trans-transveratrol could appear estrogenic actions in vivo. Moreover, its activity via subcutaneous administration was higher than that via oral administration.
Liu
Zhaoping
Z
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Yu
Bo
B
Li
Wenxian
W
Sun
Jing
J
D000818:Animals; D004717:Endometrium / Q000166:cytology / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D007529:Isoflavones; D051379:Mice; D048789:Phytoestrogens; D028321:Plant Preparations; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014621:Vagina / Q000166:cytology* / Q000187:drug effects
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D013267:Stilbenes; D000077185:Resveratrol