Interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in febrile seizures.
Proinflammatory cytokines (such as interleukin-1beta, tumor necrosis factor-alpha) and nitric oxide are known to have both direct and indirect modulating effects on neurons and neurotoxic neurotransmitters released during excitation or inflammation. We measured interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in the peripheral blood and cerebrospinal fluid of children with febrile seizures and compared our results with those of children with febrile illnesses without seizures. Twenty-nine children with febrile seizure and 15 controls were studied. The mean concentrations of interleukin-1beta and nitrite were significantly increased in the cerebrospinal fluid (P < .01) of the children with febrile seizure. There were no significant changes in serum interleukin-1beta, tumor necrosis factor-alpha, nitrite, and cerebrospinal fluid tumor necrosis factor-alpha levels. Our data support the hypothesis that increased production of interleukin-1beta in the central nervous system or increased diffusion of interleukin-1beta through the blood-brain barrier is involved in the pathogenesis of febrile seizures.
Haspolat
Senay
S
Department of Pediatric Neurology, Akdeniz University Medical School, Antalya, Turkey. senay@med.akdeniz.edu.tr
Mihçi
Ercan
E
Coşkun
Mesut
M
Gümüslü
Saadet
S
Ozben
Tomris
T
Yeğin
Olcay
O
Ozbenm
Tomris
T
D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D009573:Nitrites / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D003294:Seizures, Febrile / Q000097:blood* / Q000134:cerebrospinal fluid*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000378:metabolism*
D007375:Interleukin-1; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha