title: MR relative cerebral blood flow mapping of Alzheimer disease: correlation with Tc-99m HMPAO SPECT.
abstract: OBJECTIVE
  To evaluate the value of magnetic resonance (MR) perfusion imaging for diagnosis of Alzheimer disease (AD), the authors compared relative cerebral blood flow (CBF) maps obtained with MR perfusion imaging and technetium-99m hexamethyl-propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) in patients with AD.
  
  
  METHODS
  Eight patients with AD were studied with MR perfusion imaging and HMPAO SPECT. The relative CBF maps from the two techniques were spatially coregistered, and relative CBF values in 13 cerebral gray matter regions (total, 26 regions of interest) were compared with regression analysis. To evaluate the degree of deviation of each brain region from the regression line, a P value for the residual was calculated for each region.
  
  
  RESULTS
  A significant overall correlation was seen between the relative CBF values produced by the two techniques (r = .68, P < .0001). Smaller P values for the residuals were obtained in the anterior cingulate cortex (P = .05) and posterior cingulate cortex (P < .001), indicating larger deviations in these regions. When data from these two regions were eliminated, the correlation coefficient rose to 0.80 (P < .0001).
  
  
  CONCLUSIONS
  Despite fairly large discrepancies in the anterior and posterior cingulate cortices, the relative CBF map obtained with MR imaging is generally in close agreement with the HMPAO SPECT map, suggesting that MR perfusion imaging can provide clinically useful information regarding CBF abnormalities in patients with AD.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Futoshi
authors.initials: F
authors.lastname: Mihara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Koji
authors.initials: K
authors.lastname: Ogomori
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koga
authors.forename: Takeharu
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Kouji
authors.initials: K
authors.lastname: Masuda
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D011859:Radiography; D012039:Regional Blood Flow / Q000502:physiology*; D013223:Statistics as Topic; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime