Excessive expression of the scavenger receptor class A type I can significantly affect the serum lipids.
Scavenger receptor (SR) is characterized by its ability to bind negatively charged macromolecules, particularly the modified lipoproteins that are pertinent to the development of vascular disease. To determine the role of excessive scavenger receptor A in the serum lipoprotein metabolism, transgenic mice lines with mouse scavenger receptor A gene type I (SR-AI) under the control of human SR-AI enhancer and metallothionein gene promotor were established. After zinc induction, the expression of SR-AI in transgenic mice was a little higher than the controls, but the serum lipids levels were significantly different from the controls, especially the cholesterol. These results demonstrated that overexpression of SR-AI significantly affected the serum lipids levels.
Gao
Jun
J
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Liu
De-Pei
DP
Huang
Yue
Y
Dong
Wen-Ji
WJ
Wu
Min
M
Feng
Dong-Xiao
DX
Liang
Chih-Chuan
CC
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D018955:CD36 Antigens / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008055:Lipids / Q000097:blood*; D051379:Mice; D008822:Mice, Transgenic; D010957:Plasmids / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051117:Scavenger Receptors, Class A; D014280:Triglycerides / Q000097:blood
D018955:CD36 Antigens; D008055:Lipids; D051117:Scavenger Receptors, Class A; D014280:Triglycerides; D012313:RNA; D004247:DNA; D002784:Cholesterol