title: Blood compatible design of a pulsatile blood pump using computational fluid dynamics and computer-aided design and manufacturing technology.
abstract: Thrombus formation is a critical issue when designing a long-term implantable left ventricular assist system (LVAS). Fluid dynamic characteristics of blood flow are one of the main factors that cause thrombus formation. In this study, we optimized the fluid dynamics of a sac blood pump in our LVAS to ensure minimization of shear-related blood damage that could lead to thrombus formation. A pump housing and a sac chamber were designed with computer-aided design (CAD) software, and fluid dynamics were estimated by computational fluid dynamic (CFD) analysis. We adopted distribution of CFD results for qualitative evaluation, and we also tried to estimate normalized index of hemolysis (NIH) from the results of CFD analysis as a quantitative index of optimization for geometry of the blood pump chamber. A prototype model of the optimized blood pump was made using a three-axis computer machine tool by whittling pieces of nonfoamed polyurethane. Shear stress and theoretical NIH in the redesigned model were lower than those in the first model. Area of flow stagnation that was observed in the first model was not seen in the redesigned model. The results demonstrate that application of CAD/CAM technology to design an artificial heart contributes to optimizing a blood pump chamber for the purpose of reducing thrombus formation.
authors.affiliation: Course of Electric and Information, Graduate School of Science and Engineering, Hokkaido Tokai University, Sapporo, Japan. okamoto@de.htokai.ac.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Okamoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Taku
authors.initials: T
authors.lastname: Inoue
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
mesh_terms: D020811:Biomedical Technology; D001787:Blood Group Incompatibility / Q000503:physiopathology*; D019295:Computational Biology; D017076:Computer-Aided Design; D005240:Feasibility Studies; D006353:Heart-Assist Devices; D006461:Hemolysis / Q000502:physiology; D018056:Hemorheology; D006801:Humans; D008432:Mathematical Computing; D011474:Prosthesis Design; D011673:Pulsatile Flow / Q000502:physiology*; D033081:Shear Strength; D013927:Thrombosis / Q000503:physiopathology* / Q000517:prevention & control*