title: Chiral Lewis acid-catalyzed asymmetric Baylis-Hillman reactions.
abstract: An effective chiral Lewis acid-catalyzed asymmetric Baylis-Hillman reaction is described. Good to high enantioselectivities were obtained using 3 mol % chiral catalyst. Novel camphor-derived dimerized ligands were prepared from the condensation of (+)-ketopinic acid with the corresponding diamines and hydrazine under acidic conditions. When alpha-naphthyl acrylate was used as a Michael acceptor, the reaction is complete within 20 min with high stereoselectivity and in reasonable chemical yields.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, ROC.
authors.forename: Kung-Shuo
authors.initials: KS
authors.lastname: Yang
authors.forename: Wei-Der
authors.initials: WD
authors.lastname: Lee
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Pan
authors.forename: Kwunmin
authors.initials: K
authors.lastname: Chen