title: Successful treatment of intractable hiccup with methylphenidate in a lung cancer patient.
abstract: In a 56-year-old man with metastatic small-cell lung cancer, a persistent hiccup was refractory to classic treatments. Hyponatremia, neoplasic mediastinal involvement and liver metastases were though to be potential causative factors. Methylphenidate (MTP), a mild central nervous system (CNS) stimulant that is most commonly used for the treatment of attention deficit hyperactivity disorder, was started at a daily dose of 10 mg. It was rapidly efficient and well tolerated. This report suggests a potential advantage of MTP in the treatment of intractable hiccup in cancer patients.
authors.affiliation: Department of Internal Medicine, Institut Jules Bordet, Centre des tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Maréchal
authors.forename: T
authors.initials: T
authors.lastname: Berghmans
authors.forename: P
authors.initials: P
authors.lastname: Sculier
mesh_terms: D018288:Carcinoma, Small Cell / Q000150:complications*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006606:Hiccup / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate