An investigation of the 5-HT2C receptor gene as a migraine candidate gene.
Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition.
Johnson
Matthew P
MP
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Australia.
Lea
Rod A
RA
Curtain
Robert P
RP
MacMillan
John C
JC
Griffiths
Lyn R
LR
D016022:Case-Control Studies; D041321:Chromosomes, Human, X; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics*; D012737:Sex Factors
D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin