title: Small G proteins as novel therapeutic targets in cardiovascular medicine.
abstract: Small G proteins are implicated in regulation of endothelial function, smooth muscle cell contraction, proliferation, and migration, as well as cardiomyocyte hypertrophy. Targeting small G proteins and their downstream signaling could constitute promising therapeutic approaches in cardiovascular disorders such as atherosclerosis, restenosis, hypertension, vasospasm, and cardiac hypertrophy.
authors.affiliation: Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland.
authors.forename: Christine
authors.initials: C
authors.lastname: Barandier
authors.forename: Xiu-Fen
authors.initials: XF
authors.lastname: Ming
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans
chemical_list: D019204:GTP-Binding Proteins