A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network.
Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.
Rao
Dabeeru C
DC
Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA. rao@wubios.wustl.edu
Province
Michael A
MA
Leppert
Mark F
MF
Oberman
A l
Al
Heiss
Gerardo
G
Ellison
R Curt
RC
Arnett
Donna K
DK
Eckfeldt
John H
JH
Schwander
Karen
K
Mockrin
Steve C
SC
Hunt
Steve C
SC
D001741:Black or African American; D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D019992:Databases as Topic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006078:Government Programs; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008126:Lod Score; D009316:National Institutes of Health (U.S.); D035781:Siblings; D016615:Telomere; D014481:United States; D044465:White People / Q000235:genetics*