title: Extended longevity in mice lacking the insulin receptor in adipose tissue.
abstract: Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic abnormalities, although their food intake is normal. Both male and female FIRKO mice were found to have an increase in mean life-span of approximately 134 days (18%), with parallel increases in median and maximum life-spans. Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling.
authors.affiliation: Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Kahn
authors.forename: C Ronald
authors.initials: CR
authors.lastname: Kahn
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001824:Body Constitution; D001835:Body Weight; D031204:Caloric Restriction; D004435:Eating; D005260:Female; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011972:Receptor, Insulin / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013851:Thinness
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin