[Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
A method for the quantitative determination of 4 antiseptics (methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, n-propyl p-hydroxybenzoate, n-butyl p-hydroxybenzoate) and 6 sunscreen agents (2-hydroxy 4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy 4-methoxybenzophenone, phenyl salicylate, 2-ethylhexyl 4-dimethyl aminobenzoate, 2-ethylhexyl 4-methoxycinnamate, 2-ethylhexyl salicylate) in cosmetic products was developed successfully. It was based on a reversed-phase high performance liquid chromatographic separation under the conditions of isocratic elution with a mixture of methanol-THF-water (30:100:100, V/V) by using a column packed with 10 microns YWG-C18, and the UV detection at 254 nm and 310 nm. The recoveries(n = 6) ranged from 87.2% to 106.5%, and the relative standard deviations(n = 6) were from 1.2% to 3.3%.
Li
J
J
Beijing Municipal Center for Hygiene and Epidemic Control, Beijing 100013, China.
Kang
J X
JX
Wu
D N
DN
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D001577:Benzophenones / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003358:Cosmetics / Q000737:chemistry*; D010226:Parabens / Q000032:analysis; D013473:Sunscreening Agents / Q000032:analysis*
D000891:Anti-Infective Agents, Local; D001577:Benzophenones; D003358:Cosmetics; D010226:Parabens; D013473:Sunscreening Agents; C009361:sulisobenzone; C005290:oxybenzone; C015358:methylparaben; C038193:4-hydroxybenzoic acid