Adiponectin and protection against type 2 diabetes mellitus.
Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5.34 microg/mL [SD 3.49] vs 6.87 microg/mL [4.58], p<0.0001). High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A(1c) (odds ratio 4th vs 1st quartile 0.3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals.
Spranger
Joachim
J
Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany. spranger@mail.dife.de
Kroke
Anja
A
Möhlig
Matthias
M
Bergmann
Manuela M
MM
Ristow
Michael
M
Boeing
Heiner
H
Pfeiffer
Andreas F H
AF
D052242:Adiponectin; D000328:Adult; D000368:Aged; D001824:Body Constitution; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology; D015444:Exercise; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics / Q000302:isolation & purification*; D012307:Risk Factors; D011795:Surveys and Questionnaires
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins