The use of topiramate in refractory status epilepticus.
In cases of refractory status epilepticus (RSE) unresponsive to sequential trials of multiple agents, a suspension of topiramate administered via nasogastric tube was effective in aborting RSE, including one patient in a prolonged pentobarbital coma. Effective dosages ranged from 300 to 1,600 mg/d. Except for lethargy, no adverse events were reported.
Towne
A R
AR
Virginia Commonwealth University, Richmond, VA, 23298-0599, USA. atowne@hsc.vcu.edu.
Garnett
L K
LK
Waterhouse
E J
EJ
Morton
L D
LD
DeLorenzo
R J
RJ
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D016208:Databases, Factual / Q000706:statistics & numerical data; D004351:Drug Resistance / Q000502:physiology; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000188:drug therapy*; D000077236:Topiramate; D016896:Treatment Outcome
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose