Glucose regulation and oxidative stress in healthy centenarians.
Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
Barbieri
Michelangela
M
Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, IV Divisione di Medicina Interna, Piazza Miraglia 2, I-80138 Napoli, Italy.
Rizzo
Maria Rosaria
MR
Manzella
Daniela
D
Grella
Rodolfo
R
Ragno
Emilia
E
Carbonella
Marco
M
Abbatecola
Angela Marie
AM
Paolisso
Giuseppe
G
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005838:Genotype; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance; D008136:Longevity; D018384:Oxidative Stress; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
D007328:Insulin; D014446:Tyrosine 3-Monooxygenase; D005947:Glucose