Indolomonoterpenic alkaloids from Strychnos icaja roots.
In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near 1 microM.
Philippe
Geneviève
G
University of Liège, Natural and Synthetic Drugs Research Center, Laboratoire de Pharmacognosie, Avenue de l'Hôpital 1, B36, B-4000 Liège, Belgium.
De Mol
Patrick
P
Zèches-Hanrot
Monique
M
Nuzillard
Jean-Marc
JM
Tits
Monique-Hanrot
MH
Angenot
Luc
L
Frédérich
Michel
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015023:Democratic Republic of the Congo; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism; D013331:Strychnine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031451:Strychnos / Q000737:chemistry*
D000962:Antimalarials; D002227:Carbazoles; D026121:Indole Alkaloids; D039821:Monoterpenes; C472945:strychnohexamine; D013331:Strychnine