Initial human experience with the Amplatzer perimembranous ventricular septal occluder device.
Transcatheter closure of perimembranous ventricular septal defects with coils or devices designed to close other lesions may be complicated by embolization or aortic insufficiency. A new asymmetric Amplatzer perimembranous ventricular septal occluder and delivery system was specifically designed for perimembranous defects. This report describes the first use of this device in 27 patients. Implantation was successful in 25 (93%), with 1 removed for device-related aortic insufficiency and inability to position the delivery sheath in another. Device orientation was excellent when the device was initially advanced through a standard delivery sheath positioned in the left ventricular apex. Twenty-three had complete occlusion within 1 week (92%), with a tiny (< 2 mm) residual shunt in the other two. In the 25 subjects with the device left in place, device-related aortic or tricuspid insufficiency, arrhythmias, and embolization were not observed. These excellent acute results need to be confirmed by long-term follow-up.
Bass
John L
JL
Department of Pediatric Cardiology, University of Minnesota, Minneapolis, Minnesota, USA. bassx001@umn.edu
Kalra
G S
GS
Arora
Ramesh
R
Masura
Jozef
J
Gavora
Pavlo
P
Thanopoulos
Basil D
BD
Torres
William
W
Sievert
Horst
H
Carminati
Mario
M
Fischer
Gunther
G
Ewert
Peter
P
D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D006345:Heart Septal Defects, Ventricular / Q000628:therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018579:Patient Selection; D019736:Prostheses and Implants / Q000009:adverse effects; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D016896:Treatment Outcome