The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein.
p53 is an oncosuppressor protein, which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements. In the present study we found active responsive elements, specific for the p53 within the 5'flanking region and within the first intron of the gene encoding for the CD59 membrane inhibitor of reactive lysis, and within the first intron of the gene encoding for the CD58 membrane protein (LFA-3). The results suggest that p53 may enhance the transcription of both CD59 and CD58 and imply a novel role for p53 as a direct regulator of the immune response.
Gazouli
Maria
M
Department of Histology and Embryology, Molecular Carcinogenesis Group, School of Medicine, University of Athens, Athens, Greece.
Kokotas
Stavros
S
Zoumpourlis
Vassilis
V
Zacharatos
Panagiotis
P
Mariatos
George
G
Kletsas
Dimitris
D
Perunovic
Branko
B
Athanasiou
Athanasios
A
Kittas
Christos
C
Gorgoulis
Vassilis
V
D001483:Base Sequence; D001665:Binding Sites; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism; D018968:CD58 Antigens / Q000235:genetics*; D018957:CD59 Antigens / Q000235:genetics*; D016384:Consensus Sequence; D006801:Humans; D007438:Introns; D012516:Osteosarcoma / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D014162:Transfection; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D018968:CD58 Antigens; D018957:CD59 Antigens; D016159:Tumor Suppressor Protein p53