Polymorphism of IL-1 receptor antagonist gene: role in cancer.
BACKGROUND
IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer.


METHODS
We analysed preclinical and clinical studies.


RESULTS
A polymorphism is present in intron 2 of the human IL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer.


CONCLUSIONS
The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.
Sehouli
Jalid
J
Department of Obstetrics and Gynaecology, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany.
Mustea
Alexander
A
Könsgen
Dominique
D
Katsares
Ioanna
I
Lichtenegger
Werner
W
D000483:Alleles; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D011110:Polymorphism, Genetic; D011379:Prognosis; D012795:Sialoglycoproteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins