[Genetic polymorphism of steroid 17 alpha-hydroxylase/17,20-lyase (CYP17) and hyperinsulinemia in endometrial carcinoma].
Initiation and/or promotion of endometrial carcinoma is considered to be associated with estrogens and androgens (androstendione) excess as well as hyperinsulinemia and resistance to insulin. It is possible that certain polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to carcinoma susceptibility. In the current study, we compared the role of CYP17 biallelic MspA1) polymorphism in 114 endometrial carcinoma patients and 182 healthy women. According to our data, A2/A2 CYP17 genotype traditionally regarded as "unfavorable" was less frequent in cancer patients than in control which confirmed the results of two previous publications. For the first time, carriers of the genotype were shown to have relatively low levels of blood insulin and C-peptide. No significant difference was found between mean concentrations of testosterone, dehydroepiandrosterone sulfate and those of estradiol in the carriers of various CYP17 genotypes with endometrial cancer. Hence, CYP17 polymorphism which is represented by the "normal" A1/A1 genotype might be a factor of risk for endometrial carcinoma. Since this genetic variety may develop through an unconventional (nonsteroid) pathway, taking relevant preventive measures in high-risk groups should be recommended.
Berstein
L M
LM
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Imianitov
E N
EN
Gamaiunova
V B
VB
Kovalevskiĭ
A Iu
AIu
Kuligina
E Sh
ESh
Belogubova
E V
EV
Buslov
K G
KG
Karpova
M B
MB
Togo
A V
AV
Volkov
O N
ON
Kovalenko
I G
IG
Chernobrovkina
A E
AE
D014408:Biomarkers, Tumor / Q000235:genetics; D002096:C-Peptide / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D007328:Insulin / Q000097:blood; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
D014408:Biomarkers, Tumor; D002096:C-Peptide; D005819:Genetic Markers; D007328:Insulin; D013254:Steroid 17-alpha-Hydroxylase