[Molecular candidates for capacitative calcium entry channel].
The emptying of intracellular calcium store generates a putative signal that induces the opening of the store-operated calcium channel (SOC) at the level of the cell membrane, also known as the capacitative calcium entry (CCE), or the calcium release-activated calcium channel (CRAC), which allows entry of calcium into the cells from the extracellular space. Drosophila transient receptor potential (trp) and trp-like(trpl) genes have been identified and reported to code cation channels(TRP and TRPL). The mechanism of coupling between store depletion and channel opening is unknown. Three fundamental mechanisms have been proposed for transmitting the signal from intracellular stores to the plasma membrane: (1) a diffusible message; (2) protein-protein interactions; and (3) vesicle secretion. This review focuses primarily on the recent studies on the TRP homologues, the possible mechanisms and electrophysiological phenotypes of capacitative calcium entry.
Wang
Y H
YH
Department of Neurology, Changzheng Hospital, Shanghai 200003.
Shao
F Y
FY
D000818:Animals; D001693:Biological Transport, Active; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology*; D002148:Calmodulin-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D029721:Drosophila Proteins; D004594:Electrophysiology; D006801:Humans; D019476:Insect Proteins / Q000378:metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism / Q000502:physiology*; D050051:Transient Receptor Potential Channels
D015220:Calcium Channels; D002148:Calmodulin-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D050051:Transient Receptor Potential Channels; C063169:trp protein, Drosophila; C074192:trpl protein, Drosophila