Angiography for diagnosis and treatment of colorectal cancer.
OBJECTIVE
To evaluate the role of preoperative angiography in the diagnosis and treatment of colorectal cancer.


METHODS
The authors performed selective arterial cannulation by Seldinger's method in 47 patients to locate the primary cancer and to diagnose metastasis to the liver. Each patient was then given intra-arterial regional chemotherapy, and received 5-fluorouracil (5-Fu, 1 000 mg), mitomycin C (MMC, 20 mg), and cisplatinum (CDDP, 80 mg).


RESULTS
The location and shape of each tumor were observed, including metastatic tumors in the liver, in 42 of the 47 (89.4 %) patients. The site of the primary tumor was difficult to identify in 5 cases because the patients had a recurrence of cancer. Arterial chemotherapy was performed successfully in all patients. The authors recorded no partial or significant morbidity resulted from angiography. The only incident was bleeding from the artery puncture site in one patient, which was successfully stopped by general medication.


CONCLUSIONS
Preoperative selective arterial angiography can help the diagnosis and locate primary tumors and to detect liver metastasis. At the same time, regional arterial chemotherapy can be an important form of preoperative therapy.
Gu
Jin
J
Department of Surgery, Oncology School of Peking University, 52 FuCheng Road, Beijing 100036, China. jingu_1999@yahoo.com
Ma
Zhao-Lai
ZL
Li
Ying
Y
Li
Ming
M
Xu
Guang-Wei
GW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial / Q000009:adverse effects; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents