title: Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity.
abstract: BACKGROUND: Wolf-Hirschhorn syndrome is caused by distal deletion of the short arm of chromosome 4 (4p-). We report a case in which intrauterine growth restriction, hypospadias and foot deformity were detected by prenatal ultrasound examination at 29 weeks of gestation. CASE PRESENTATION: A 31-year-old gravida 2 partus 1 woman was referred at 29 weeks' gestation with suspicion of intrauterine growth restriction. Sonographic examination revealed deformity of the right lower limb and undescended testes with an irregular distal penis. A cordocentesis was performed and chromosome analysis revealed a 46,XY,del(4)(p14) karyotype. CONCLUSION: The prenatal detection of intrauterine growth restriction, hypospadias and foot deformity should lead doctors to suspect the presence of Wolf-Hirschhorn syndrome.
authors.affiliation: Department of Perinatology, SSK Bakirkoy Maternity and Children Hospital, Istanbul, Turkey. halil34aslan@hotmail.com
authors.forename: Halil
authors.initials: H
authors.lastname: Aslan
authors.forename: Nilay
authors.initials: N
authors.lastname: Karaca
authors.forename: Seher
authors.initials: S
authors.lastname: Basaran
authors.forename: Hayri
authors.initials: H
authors.lastname: Ermis
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Ceylan