title: Proteomic technologies to study diseases of the lymphatic vascular system.
abstract: Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these new proteomic technologies to study cellular activities, will lead to a faster sample throughput and increased sensitivity for the detection of individual proteins, thus providing major opportunities for the discovery of new biomarkers for the early detection of protein alterations associated with the progression of the disease state.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Lee V
authors.initials: LV
authors.lastname: Leak
authors.forename: Emanuel F
authors.initials: EF
authors.lastname: Petricoin
authors.forename: Michael
authors.initials: M
authors.lastname: Jones
authors.forename: Cloud P
authors.initials: CP
authors.lastname: Paweletz
authors.forename: Ali M
authors.initials: AM
authors.lastname: Ardekani
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Fusaro
authors.forename: Sally
authors.initials: S
authors.lastname: Ross
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta
mesh_terms: D000818:Animals; D006801:Humans; D008206:Lymphatic Diseases / Q000235:genetics* / Q000503:physiopathology*; D008208:Lymphatic System / Q000503:physiopathology*; D009363:Neoplasm Proteins / Q000235:genetics; D011506:Proteins / Q000235:genetics; D020543:Proteome; D012107:Research Design
chemical_list: D009363:Neoplasm Proteins; D011506:Proteins; D020543:Proteome