[Effects of para-aminobenzoic acid (PABA) on growth of Streptococcus mutans].
OBJECTIVE
The aim of this study is to examine effects of para-aminobenzoic acid (PABA) on the growth of Streptococcus mutans (S. mutans).


METHODS
Different concentrations of PABA (10(-10)-10(-3) g/L) were separately transferred to modified Carlsson medium. S. mutans (ATCC 25175) grew in modified Carlsson medium with different concentrations of PABA. All cultures were incubated at 37 degrees C anaerobically in an atmosphere of 80% of nitrogen (v/v), 10% of hydrogen (v/v) and 10% of carbon dioxide (v/v) for 48 hours. The absorbance values of S. mutans were measured by using a spectrometer (UV-1601). The colony forming units (CFU) were obtained by growing S. mutans in media with different concentrations of PABA (10(-10)-10(-3) g/L).


RESULTS
Different concentrations of PABA had different stimulating effects on the growth of S. mutans (P < 0.05). But this kind of stimulating effects declined when the concentration of PABA was 10(-3) g/L.


CONCLUSIONS
This experiment indicates PABA has stimulating effects on the growth of S. mutans, and PABA can promote growth of S. mutans.
Guo
B
B
College of Stomatology, West China University of Medical Sciences.
Zhou
X
X
Xiao
X
X
Hu
T
T
Zhu
Z
Z
Li
L
L
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid