[Telomeres and genomic damage repair. Their implication in human pathology].
Telomeres, functional complexes that protect eukaryotic chromosome ends, participate in the regulation of cell proliferation and could play a role in the stabilization of genomic regions in response to genotoxic stress. Their significance in human pathology becomes evident in several diseases sharing genomic instability as a common trait, in which alterations of the telomere metabolism have been demonstrated. Many of them are also associated with hypersensitivity to ionizing radiation and cancer susceptibility. Besides the specific proteins belonging to the telomeric complex, other proteins involved in the DNA repair machinery, such as ATM, BRCA1, BRCA2, PARP/tankyrase system, DNA-PK and RAD50-MRE11-NBS1 complexes, are closely related with the telomere. This suggests that the telomere sequesters DNA repair proteins for its own structure maintenance, which could also be released toward damaged sites in the genomic DNA. This communication describes essential aspects of telomere structure and function and their links with homologous recombination, non-homologous end-joining (NHEJ), V(D)J system and mismatch-repair (MMR). Several pathological conditions exhibiting alterations in some of these mechanisms are also considered. The cell response to ionizing radiation and its relationship with the telomeric metabolism is particularly taken into account as a model for studying genotoxicity.
Pérez
Maria del Rosario
Mdel R
Autoridad Regulatoria Nuclear, Gerencia de Apoyo Científico, Laboratorio de Radiopatología, Buenos Aires, Argentina.
Dubner
Diana
D
Michelín
Severino
S
Gisone
Pablo
P
Carosella
Edgardo
E
D017209:Apoptosis / Q000502:physiology; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004789:Enzyme Activation; D006801:Humans; D019098:Telomerase / Q000502:physiology; D016615:Telomere / Q000502:physiology* / Q000528:radiation effects
D019098:Telomerase