Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity.
Immune mechanisms have important roles in the pathogenesis of atherosclerosis. The present study was conducted to evaluate the association of pulse wave velocity (PWV) with either hepatitis C or B. In 7514 subjects, we determined the PWV, as well as the plasma levels of hepatitis B virus antigen and antibody and of hepatitis C virus antibody. The results of multiple regression analysis showed that seropositivity for hepatitis C virus was a significant variable for PWV independent from atherosclerotic risk factors. Thus, hepatitis C virus seropositivity was associated with increased PWV.
Tomiyama
Hirofumi
H
Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. tomiyama@tokyo-med.ac.jp
Arai
Tomio
T
Hirose
Ken-ichi
K
Hori
Sabroh
S
Yamamoto
Yoshio
Y
Yamashina
Akira
A
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000276:immunology*; D001783:Blood Flow Velocity; D002353:Carrier State; D015331:Cohort Studies; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010991:Plethysmography; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D018709:Statistics, Nonparametric
D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies