Individualizing salvage regimens: the inhibitory quotient (Ctrough/IC50) as predictor of virological response.
Increased drug levels could overcome resistance and improve the response to a salvage regimen. We evaluate the inhibitory quotient (IQ, Ctrough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens. The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1. The IQ could be useful to improve the virological response to a dual PI salvage regimen.
Casado
Jose L
JL
Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain.
Moreno
Ana
A
Sabido
Raquel
R
Martí-Belda
Paloma
P
Antela
Antonio
A
Dronda
Fernando
F
Perez-Elías
María J
MJ
Moreno
Santiago
S
D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000097:blood* / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D016879:Salvage Therapy
D017320:HIV Protease Inhibitors