Structural considerations of autoantibodies.
The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptide-specific, as some accelerated the autoimmune response. Furthermore, this was associated with suppression of IFN-g and IL-4 in serum and increased TGF-b. Recent isolation of peptide-specific T cells should be helpful in sorting out the mechanisms responsible for these events. In separate studies, it was demonstrated that an anti-DNA antibody that enters cells is able to transport proteins linked to it, supporting the possibility that this system can be used as a therapeutic modality to modify specific cellular activities.
Madaio
M P
MP
Renal and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA. madaio@mail.med.upenn.edu
Naparstek
Y
Y
D000818:Animals; D001323:Autoantibodies / Q000737:chemistry* / Q000276:immunology*; D016503:Drug Delivery Systems; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies