Triethyl- (or trimethyl-)silyl triflate-catalyzed reductive cleavage of triphenylmethyl (trityl) ethers with triethylsilane.
[reaction: see text] A triphenylmethyl (trityl) ether was reductively and instantaneously cleaved by triethylsilane in the presence of a catalytic amount of TES- (or TMS)-triflate. The reaction conditions are mild enough to achieve reduction in the presence of a variety of acid-sensitive functional groups. Upon a mild acidic treatment of the crude product, the corresponding alcohol is obtained in high yield.
Imagawa
Hiroshi
H
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Tsuchihashi
Tomoko
T
Singh
Rajesh K
RK
Yamamoto
Hirofumi
H
Sugihara
Takumichi
T
Nishizawa
Mugio
M