Biologically active phenols from Saussurea medusa.
Sixteen phenolic compounds were isolated from the polar fraction of Saussurea medusa and were structurally elucidated by chemical evidences and spectral methods. These compounds include two new lignan glucosides, namely medusasides A (1) and B (2), and fourteen known phenolic compounds (3-16). One major compound, apigenin 7-O-[alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside] (6) showed remarkable activity to attenuate the scopolamine induced memory deficit of mice. Compound 6 and another major one, quercetin (8) also exhibited moderate cell protecting activities against hydrogen peroxide (H(2)O(2)) induced PC12 cell damage.
Fan
Cheng-Qi
CQ
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, PR China.
Yue
Jian-Min
JM
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D018727:Muscarinic Antagonists; D016877:Oxidants / Q000633:toxicity; D016716:PC12 Cells; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D030441:Saussurea / Q000737:chemistry*; D012601:Scopolamine; D021241:Spectrometry, Mass, Electrospray Ionization
D000975:Antioxidants; D018727:Muscarinic Antagonists; D016877:Oxidants; D010636:Phenols; D006861:Hydrogen Peroxide; D012601:Scopolamine