[Expression of TGF-beta 1 and proliferation of collagen in myocardium in viral myocarditis].
To investigate the tissue repair of acute viral myocarditis, and to explore the diagnostic method of slight viral myocarditis in forensic pathology. Slight viral myocarditis model was induced in Balb/c murine by CVB3. Collagen proliferation in myocardium of mice with myocarditis was observed by special staining. The hearts of mice and human(9 cases) with myocarditis were studied LSAB-immunohistochemically with anti-TGF-beta 1 antibody. In the study, the proliferation of collagen was seen in myocardium in acute viral myocarditis. Generous expression of TGF-beta 1 was found in the myocardium of mice and human with myocarditis. The quantity of collagen proliferation and expression of TGF-beta 1 was positive correlation. It is concluded that the tissue repair exists in acute viral myocarditis and that positive staining of myocardium for TGF-beta 1 is a sensitive index of myocardial damage and tissue repair.
Cheng
J
J
Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D003384:Coxsackievirus Infections; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000473:pathology* / Q000821:virology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
D016212:Transforming Growth Factor beta; D003094:Collagen