Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation.
BACKGROUND
To analyze the effects of postprandial hypertriglyceridemia with or without antioxidant supplementation-on endothelial function as related to lipid oxidation in healthy young subjects.


RESULTS
Ten healthy male subjects (mean age: 26 years) were examined three times in fasting state (10 hours) following a high-fat meal, a low-fat meal, or a high-fat meal with additional antioxidant vitamin E (800 IU), respectively. Serum triglycerides significantly increased 2 and 4 hours after eating the high-fat meal with or without additional vitamin E. Endothelium-dependent, flow-mediated brachial artery vasodilations (FMD; percentage change in diameter) changed from 13.3+/-1.1% to 6.6+/-1.1% (p<0.05), 7.1+/-0.6% (p<0.05), or 13.2+/-0.8% at 2, 4, or 6 hours after eating a high-fat meal. However, there were no changes of FMD observed following either a low-fat meal or a high-fat meal with additional vitamin E. The flow-dependent vasodilation inversely correlated to postprandial hypertriglyceridemia (r=-0.54, p<0.05). Serum malondialdehydes (MDA; lipid oxidation products) did not significantly change following ingestion of any of the 3 types of meal.


CONCLUSIONS
This study suggests that postprandial hypertriglyceridemia-induced endothelial dysfunction is not associated with lipid oxidation and that the protective effects of vitamin E on endothelial function may be due to some alternative, as of yet unknown, mechanism.
Bae
Jang-Ho
JH
Division of Cardiology, College of Medicine, Konyang University Hospital, Daejeon, South Korea. jhbae@kyuh.co.kr
Schwemmer
Michael
M
Lee
In-Kyu
IK
Lee
Hee-Ja
HJ
Park
Ki-Rack
KR
Kim
Ki-Young
KY
Bassenge
Eberhard
E
D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage*; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000502:physiology; D015331:Cohort Studies; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004730:Endothelium, Vascular / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D019518:Postprandial Period; D011336:Probability; D012016:Reference Values; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D004041:Dietary Fats; D014810:Vitamin E; D008315:Malondialdehyde