title: Simultaneous molecular and anatomical imaging of the mouse in vivo.
abstract: Non-invasive imaging technologies are opening up new windows into mouse biology. We have developed a mouse imaging system that integrates positron emission tomography (PET) with x-ray computed tomography (CT), allowing simultaneous anatomic and molecular imaging in vivo with the potential for precise registration of the two image volumes. The x-ray system consists of a compact mini-focal x-ray tube and an amorphous selenium flat panel x-ray detector with a low-noise CMOS readout. The PET system uses planar arrays of lutetium oxyorthosilicate scintillator coupled to position-sensitive photomultiplier tubes. We describe the design of this dual-modality imaging system and show, for the first time, simultaneously acquired PET and CT images in a phantom and in mice.
authors.affiliation: Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. agoertzen@mednet.ucla.edu
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Goertzen
authors.forename: A Ken
authors.initials: AK
authors.lastname: Meadors
authors.forename: Robert W
authors.initials: RW
authors.lastname: Silverman
authors.forename: Simon R
authors.initials: SR
authors.lastname: Cherry
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D007089:Image Enhancement / Q000295:instrumentation; D007668:Kidney / Q000000981:diagnostic imaging; D051379:Mice; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D013382:Subtraction Technique / Q000295:instrumentation*; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D014915:Whole-Body Counting / Q000379:methods
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18