[The relation between translation speed and protein secondary structure].
Based on the statistical analysis of 119 human and 92 E. coli proteins it was found that for both human and E. coli, the mRNA sequences consisting of tri-codon and tetra-codon with high translation speed preferably code for alpha helices more than for coils. For beta strand, the preference/avoidance oscillates with the translation speed. Moreover, the non-homogeneous usages of tri-codon and tetra-codon with different translation speeds in a given secondary structure have also been found. These results cannot be simply explained by the effect of stochastic fluctuation.
Li
Xiao-Qin
XQ
Kunming Institute of Zoology, the Chinese Academy of Sciences, China.
Luo
Liao-Fu
LF
Liu
Ci-Quan
CQ
D003062:Codon / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics
D003062:Codon; D029968:Escherichia coli Proteins; D011506:Proteins; D012333:RNA, Messenger