A case of primary cutaneous histoplasmosis in a patient with diabetes and multi-infarct dementia.
We report a case of primary cutaneous histoplasmosis in a fifty-year-old African-American woman with diabetes and multi-infarct dementia. The patient developed fever and crusted, nodulo-ulcerative lesions of the skin after accidental superficial trauma to the forehead. The biopsy revealed suppurative granulomatous inflammation with intracellular and extracellular yeast-like cells with associated clear halo measuring 3-4 mm in size. Systemic involvement was not found. The lesions cleared after treatment with itraconazole 200 mg twice a day for 3 weeks. The medication was continued for a total period of 3 months, with no signs of recurrence after one-year of follow-up.
Krunic
Aleksandar L
AL
Section of Dermatology, University of Chicago, Chicago, Illinois, USA.
Carag
Henry
H
Medenica
Maria M
MM
Lorincz
Allan L
AL
D001707:Biopsy, Needle; D015161:Dementia, Multi-Infarct / Q000150:complications / Q000175:diagnosis*; D003881:Dermatomycoses / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D017964:Itraconazole / Q000008:administration & dosage; D008875:Middle Aged; D018570:Risk Assessment; D016896:Treatment Outcome
D017964:Itraconazole