Primary Hodgkin's disease of the nasopharynx: a rare but bona fide disease.
We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated polypoid mass of the nasopharynx was observed in a 41-year-old man presenting with increasing bilateral nasal obstruction. Histological study revealed a mixed cellularity type of Hodgkin's disease. Immunohistochemical analysis revealed CD30 and LMP1 expression and a lack of reactivity to CD15, CD3 and CD20. Serological tests excluded recent infection with Epstein-Barr virus. HD of nasopharynx is rare, but has to be recognized as such in view of appropriate treatment.
Abbes
I
I
Histopathology Department, Salah Azaiez Institute, 10006 Bab Saadoun, Tunis, Tunisia.
Mrad
K
K
Sassi
S
S
Jellouli
M
M
Kochbati
L
L
Maalej
M
M
Ben Romdhane
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000473:pathology / Q000532:radiotherapy; D004854:Herpesvirus 4, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D008297:Male; D015508:Nasal Obstruction / Q000209:etiology; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D012074:Remission Induction; D012913:Snoring / Q000209:etiology; D014763:Viral Matrix Proteins / Q000032:analysis
D000914:Antibodies, Viral; D014408:Biomarkers, Tumor; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D017730:Ki-1 Antigen; D014763:Viral Matrix Proteins