[The determination of p53 protein in maxillary sinus carcinoma and its prognosis value].
OBJECTIVE
To determine whether p53 protein overexpression correlated with early tumor recurrence in carcinoma of maxillary sinus.


METHODS
Forty-five patients with T2N0M0 squamous cell carcinoma of maxillary sinus were treated with operation and/or radiotherapy. The median follow up time was 3 years. The ratio of local control was 62.2% (28 patients), as control group; The ratio of local recurrence and/or metastasis was 37.8% (17 patients), as experiment group. Cancer specimens were obtained before treatment. p53 protein overexpression, which indicated a mutated p53 gene, was analyzed by immunohistochemistry, using the mouse monoclonal antibody DO-7.


RESULTS
Approximately 88.2% of the carcinoma that recurred locally overexpressed p53 protein, compared with only 28.6% of those with local control (P < 0.01). No significant relation was noted between p53 protein overexpression and pathohistologic grade. Intensity of staining did not predict tumor recurrence.


CONCLUSIONS
The study demonstrated that the p53 protein is an important prognostic marker on gene level for maxillary sinus carcinoma.
Yu
Y
Y
Department of Otolaryngology, General Hospital of Shenyang Military Region, Shenyang 110015.
Dong
W
W
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D005260:Female; D016158:Genes, p53; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53