title: [Relationship between the genotypes of hepatitis B virus and the severity of liver diseases].
abstract: OBJECTIVE
  To investigate the relationship between different genotypes of hepatitis B virus (HBV) and the severity of liver diseases.
  
  
  METHODS
  The S nucleotide sequences of HBV strains isolated from plasma samples of 284 patients were detected and compared. Among them, 87 patients were HBV asymptomatic carriers (ASC), 157 chronic hepatitis B (CHB), 22 liver cirrhosis (LC), and 18 hepatocellular carcinoma (HCC).
  
  
  RESULTS
  Genotypes B and C were predominant, with a 26.1% proportion and a 63.2% proportion respectively. The percentage of genotypes B and C in patients with ASC, CHB, LC, and HCC were significantly different (x(2)=15.09, P<0.001). Compared with genotype B, genotype C was more common in patients with CHB and HCC (59.6% vs 43.2%, chi(2)=10.87, P<0.001; 7.7% vs 1.4%, x(2)=7.41, P<0.001), but in patients with LC there was no different (7.7% vs 8.1%, chi(2)=1.29, P>0.05).
  
  
  CONCLUSIONS
  This study suggests that genotype B and C are predominant. And genotype C may induce more severe the liver inflammation than genotype B may do.
authors.affiliation: Institute of Liver Diseases and People's Hospitol, Beijing University, Beijing 100044, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Qi Xin
authors.initials: QX
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Jiang
authors.forename: Liu Ming
authors.initials: LM
authors.lastname: Yang
authors.forename: Yan Long
authors.initials: YL
authors.lastname: Zhao
authors.forename: Hong Song
authors.initials: HS
authors.lastname: Chen
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors