Association study between dopamine D3 receptor gene variant and personality traits.
Dopamine receptor gene variation has been hypothesized to influence personality traits characterized by novelty seeking and related traits. We analyzed a dopamine D(3) receptor gene (DRD3) variant in a Swedish population (n = 373) investigated with one or more of several personality questionnaires. No significant relationships were found between DRD3 genotypes and any of the 15 Karolinska Scales of Personality (KSP) and five Health-relevant Personality 5 factor inventory (HP5i) scales. The DRD3 variant was associated with some scales related to novelty seeking: the Swedish universities Scales of Personality (SSP) Adventure Seeking and the revised NEO personality inventory (NEO-PI-R) Fantasy (O1) and Order (C2) scales. There were also associations with the Temperament and Character Inventory (TCI) Cooperativeness and Compassion (C4) scales. After correction for multiple testing, however, no significant difference remained. We conclude that the investigated DRD3 polymorphism does not have a major impact on personality in the investigated population.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden. erikj@ks.se
Burgert
Edgar
E
Crocq
Marc-Antoine
MA
Gustavsson
J Petter
JP
Forslund
Kaj
K
Mattila-Evenden
Marja
M
Rylander
Gunnar
G
Flyckt
Lena K
LK
Bjerkenstedt
Lars
L
Wiesel
Frits-Axel
FA
Asberg
Marie
M
Bergman
Hans
H
D019943:Amino Acid Substitution; D000850:Anomie; D005787:Gene Frequency; D014644:Genetic Variation / Q000502:physiology*; D005838:Genotype; D006801:Humans; D020125:Mutation, Missense; D010551:Personality / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology; D050637:Receptors, Dopamine D3; D011795:Surveys and Questionnaires; D013694:Temperament
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3