[The influence of basic fibroblast growth factor on the adherence of endothelial cell to polyurethane].
This study addressed the problem of how to promote the adherence of endothelial cells (EC) to polyurethane (PU). The influence of basic fibroblast growth factor (bFGF) on the adherence of EC to PU was observed by using the fluorescent method. The results showed that the attachment rates for two bFGF groups(PU precoated with fibronectin and PU precoated with collagen IV) were 71% and 68.5%, which were significantly higher than those (62.5% and 55.25%) for two control groups, respectively. These demonstrate that bFGF can promote EC attachment to PU, and suggest that bFGF can be used as a supplement factor in media for achievement of endothelialization on artificial heart and blood vessels.
Zhou
X
X
Dept. of Pathology, Medical College, Jinan University, Guangzhou 510632.
Deng
Y
Y
D000818:Animals; D001011:Aorta / Q000166:cytology; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D011140:Polyurethanes; D013552:Swine
D011140:Polyurethanes; D016222:Fibroblast Growth Factor 2