The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill patients.
OBJECTIVE
To investigate the effect of famotidine on gastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux (DGER) and to explore it's possible mechanisms. To identify the relevant factors of the reflux.


METHODS
Nineteen critically ill patients were consecutively enrolled in the study. Dynamic 24 hours monitoring of GER and DGER before and after administration of famotidine was performed. The parameters of gastric residual volume, multiple organ disorder syndrome (MODS) score, acute physiology and chronic health evaluation II (APACHE II) score and PEEP were recorded. Paired t test; Wilcoxon signed ranks test and Univariate analysis with Spearman's rank correlation were applied to analyse the data.


RESULTS
Statistical significance of longest acid reflux, reflux time of pH<4 and fraction time of acid reflux was observed in ten critically ill patients before and after administration. P value is 0.037, 0.005, 0.005 respectively. Significance change of all bile reflux parameters was observed before and after administration. P value is 0.007,0.024, 0.005, 0.007, 0.005. GER has positive correlation with APACHE II score and gastric residual volume with correlation coefficient of 0.720, 0.932 respectively.


CONCLUSIONS
GER and DGER are much improved after the administration of famotidine. GER is correlated with APACHE II score and gastric residual volume.
Xin
Ying
Y
Department of Gastroenterology,Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang Province, China. xinying20012001@yahoo.com.cn
Dai
Ning
N
Zhao
Lan
L
Wang
Jian-Guo
JG
Si
Jian-Ming
JM
D000328:Adult; D000368:Aged; D001655:Bile Reflux / Q000188:drug therapy; D016638:Critical Illness; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
D015738:Famotidine