title: [Gigantism with low serum level of growth hormone: a case report].
abstract: Gigantism with low or normal basal concentrations of growth hormone (GH) is a rare condition, possibly due to abnormal GH secretory patterns, enhanced tissue sensitivity to GH, or the existence of an unidentified growth promoting factor. Here we report an 11 year-old female case of gigantism with a normal pituitary gland. Her height was 181 cm, body weight 77 kg, and bone age 11.1 years. Her basal serum GH levels were lower than 1 ng/ml. The levels of T3, T4, FT3, FT4, TSH, E2, LH, FSH, PRL, PTC and ACTH were normal. Serum GH response to insulin-induced hypoglycemia or arginine stimulation tests was blunted. In this case, non-pulsatile GH secretion and enhanced tissue sensitivity to GH may induce hypersecretion of IGF-1 and the existence of an unidentified growth promoting factor or biologically active anti-GH receptor antibodies may cause clinical gigantism.
authors.affiliation: Endocrinology/Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
authors.forename: X
authors.initials: X
authors.lastname: Ran
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Xiong
authors.forename: T
authors.initials: T
authors.lastname: Zhao
authors.forename: N
authors.initials: N
authors.lastname: Tong
authors.forename: X
authors.initials: X
authors.lastname: Li
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005877:Gigantism / Q000097:blood* / Q000175:diagnosis; D013006:Growth Hormone / Q000097:blood*; D006801:Humans
chemical_list: D013006:Growth Hormone