title: [Evaluation of clinical diagnostic guidelines for idiopathic pulmonary fibrosis].
abstract: OBJECTIVE
  To analyze the international consensus statement on diagnostic criteria for idiopathic pulmonary fibrosis.
  
  
  METHODS
  All patients diagnosed of any interstitial lung disease by means of open lung biopsy since 1980 were included. The patients' clinical records were examined to determine whether they fulfilled the diagnostic criteria, and their biopsies were reviewed to find those with the usual interstitial pneumonia pattern. We calculated sensitivity, specificity, positive and negative predictive values and likelihood ratios for the diagnostic criteria in the consensus statement. Afterwards, we performed the analyses again using only one of the two conditions for fulfilling the function criterion.
  
  
  RESULTS
  Of 39 patients enrolled in the study, 17 had idiopathic pulmonary fibrosis. Specificity and positive predictive value were both 100%, but sensitivity was 41.2% and negative predictive value was 68.7%. The likelihood ratio for a negative result was 0.59. In the second analysis, sensitivity was 64.7% and negative predictive value was 78.5%, while specificity and positive predictive value remained unchanged. The likelihood ratio for a negative result was 0.35.
  
  
  CONCLUSIONS
  The criteria are sufficiently specific to allow us to diagnose confidently when the criteria are fulfilled. However, a slight change in the function criterion should be considered in order to increase diagnostic yield.
authors.affiliation: Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocio, Sevilla, España. lcampos@hcs.es
authors.forename: J L
authors.initials: JL
authors.lastname: López-Campos Bodineau
authors.forename: L
authors.initials: L
authors.lastname: Gómez Izquierdo
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Becerra
authors.forename: J
authors.initials: J
authors.lastname: Martín Juan
authors.forename: M
authors.initials: M
authors.lastname: Fajardo Cascos
authors.forename: F
authors.initials: F
authors.lastname: Borderas Naranjo
authors.forename: J
authors.initials: J
authors.lastname: Castillo Gómez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic / Q000592:standards*; D011237:Predictive Value of Tests; D011658:Pulmonary Fibrosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity