[Cholestasis from ticlopidine: two clinical cases].
The development of cholestasis during treatment with ticlopidine is an uncommon event in view of the large number of patients to whom this drug is prescribed. We describe the cases of 2 patients who had been treated with ticlopidine for 4 weeks and 2 months respectively. The first patient developed cholestasis with jaundice and pruritus while the second presented with biochemical cholestasis but no jaundice. When treatment with ticlopidine was withdrawn, in the first case pruritus disappeared and jaundice improved. In both cases the liver function tests returned to normal. Both patients were treated with ursodeoxycholic acid which might have an anticholestatic effect in case of hepatotoxicity induced by ticlopidine.
Varvello
Loris
L
Divisione di Medicina Interna, Ospedale Cottolengo di Torino.
Arnò
Celeste
C
Coggiola
Marisa
M
Ramassotto
Elena
E
Pascale
Claudio
C
D000368:Aged; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002779:Cholestasis / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D002756:Cholagogues and Choleretics; D005343:Fibrinolytic Agents; D014580:Ursodeoxycholic Acid; D013988:Ticlopidine