Evaluation of a possible role of tissue inhibitor of metalloproteinases 1 (TIMP-1) in the pathogenesis of hydatid disease.
Tissue inhibitor of metalloproteinases-1 (TIMP-1), in the serum levels of 27 patients was significantly higher and almost a double of that measured in healthy patients. Considerably higher TIMP-1 levels were recovered in patients with higher specific antibody titers and those with hepatic cysts in relation to low-titer patients and pulmonary cysts respectively, reflecting an immunologic dose-dependent and cell type-specific regulation of TIMP-1 production. Yet, these higher TIMP-1 levels stop short to be statistically significant in both groups. Patients with multi-sited hydatid cysts also show statistically insignificant higher TIMP-1 levels compared to single-sited cysts.
Afifi
M A
MA
Department of Parasitology, Faculty of Medicine, University of El-Minia, Cairo 11566, Egypt.
Tawfeek
G M
GM
el-Hoseiny
L M
LM
D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D004443:Echinococcosis / Q000097:blood* / Q000276:immunology / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
D000909:Antibodies, Helminth; D019715:Tissue Inhibitor of Metalloproteinase-1