[Determination of nifedipine content and its uniformity in tablets by high performance liquid chromatography].
An HPLC method with diazepam as internal standard was developed to determine nifedipine content and its uniformity in tablets. The analytical column was a C18 column, the mobile phase consisted of V (methanol):V(triethylamine, pH 5.20) = 68:32. The detection was carried out with UV detector (lambda = 237 nm). Under this condition, the linear range was wide(8-80 mg/L) and the recovery was high (99.86%). The proposed method is simple and accurate and the decomposed product can be separated as well. Therefore, the quality of nifedipine tablets can be effectively controlled.
Xing
Y
Y
Shandong Institute of Pharmaceutical Industry, Jinan, 250100.
Wang
J
J
D002851:Chromatography, High Pressure Liquid; D016014:Linear Models; D009543:Nifedipine / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D013607:Tablets
D013607:Tablets; D009543:Nifedipine