Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450.
This article provides a personal account of the discovery of the induced synthesis of drug-metabolizing enzymes and of subsequent research that led to the discovery of multiple cytochromes P450 with different catalytic activities. The manuscript also emphasizes the role of environmental factors (in addition to genetic polymorphisms) in explaining person-to-person and day-to-day differences in rates and pathways of drug metabolism that occur in the human population.
Conney
Allan H
AH
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA. aconney@rci.rutgers.edu
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000266:history*; D004790:Enzyme Induction; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D014116:Toxicology / Q000266:history
D003577:Cytochrome P-450 Enzyme System