[Clinical comparison between intraoperative local arterial infusion chemotherapy and systemic venous chemotherapy of gastric cancer].
OBJECTIVE
To evaluate the effect of intraoperative local arterial infusion chemotherapy for gastric cancer.


METHODS
The effects of intraoperative local arterial infusion chemotherapy in 40 patients with gastric cancer were assessed. Twenty-four patients with gastric cancers who underwent the intraoperative systemic chemotherapy were taken as controls. The removed specimens were examined microscopically to show the degeneration and necrosis of the tumour cell.


RESULTS
After the treatment of the tumour cells, all of the cases in the study group showed various degrees of degeneration and necrosis. The immediate effective rate was 95% for the the study group but only 41.67% for the control group (P < 0.05).


CONCLUSIONS
Intraoperative local arterial infusion chemotherapy for gastric cancer has good immediate effect and little side effect; it prevents the intraoperative iatrogenic metastases and implantation and decreases the postoperative recurrence of gastric cancer.
Xiao
Q
Q
Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Peng
B
B
Lai
Y
Y
Zhang
S
S
Chen
D
D
D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery*
D016685:Mitomycin; D004317:Doxorubicin; D005472:Fluorouracil