title: Clinicopathological, ultrasonographic, and histopathological findings of superficial necrolytic dermatitis with hepatopathy in a cat.
abstract: This report describes the antemortem diagnosis and antemortem and postmortem findings of superficial necrolytic dermatitis with hepatopathy (i.e., hepatocutaneous syndrome) in a cat. A 5-year-old Maine coon was evaluated because of a history of pruritic alopecia and liver enzyme elevations. Abdominal ultrasonography revealed a reticular pattern to the hepatic parenchyma. Histopathological findings of the liver were nodular regeneration with bands of vacuolated hepatocytes and bile duct hyperplasia, characteristic of the hepatopathy frequently associated with superficial necrolytic dermatitis. Skin histopathology revealed multifocal parakeratosis, midepidermal spongiosis, and basal cell hyperplasia consistent with superficial necrolytic dermatitis.
authors.affiliation: Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104-6010, USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Kimmel
authors.forename: Wendy
authors.initials: W
authors.lastname: Christiansen
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Byrne
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002415:Cats; D003872:Dermatitis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D009336:Necrosis; D013577:Syndrome; D014463:Ultrasonography
chemical_list: D000410:Alanine Transaminase