Direct organocatalytic aldol reactions in buffered aqueous media.
Organocatalytic cross-aldol reactions catalyzed by cyclic secondary amines in aqueous media provide a direct route to a variety of aldols including carbohydrate derivatives and may warrant consideration as a prebiotic route to sugars.
Córdova
Armando
A
Skaggs Institute for Chemical Biology, Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Notz
Wolfgang
W
Barbas
Carlos F
CF
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002021:Buffers; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007659:Ketones / Q000737:chemistry*
D000447:Aldehydes; D000588:Amines; D002021:Buffers; D007659:Ketones