title: 5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula.
abstract: A polyethylenic fatty ester was isolated from the marine sponge Chondrilla nucula. The structure was elucidated through NMR spectral data and MS analysis as 5,9,23-triacontatrienoic methyl ester 1. Compound 1 is an elastase inhibitor [ID50 = 10 microg/mL (2 x 10(-5) M)].
authors.affiliation: Laboratoire de Chimie, ESA 8041 C.N.R.S., Muséum National d'Histoire Naturelle, F-75005 Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Meyer
authors.forename: Michèle
authors.initials: M
authors.lastname: Guyot
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*
chemical_list: C480298:5,9,23-triacontatrienoic methyl ester; D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D010196:Pancreatic Elastase