[Research progress in physiological functions of selenoenzyme and other selenocompounds].
Selenium (Se) is an essential trace element for animals. Selenocysteine (Sec), the 21st aminoacid, is a component of selenoproteins and has been founded in the active center of selenoenzymes. The functions of Se within the body have been primarily shown in the forms of selenoproteins, especially selenoenzymes. Incorporation of selenocysteine occurs on the basis of genetic expression and Se is the only trace element under direct genetic control. Recently, findings have shown that Se and selenocompounds conducted many other potential functions such as protection against inflammatory factors, inhibition of protein kinase C (PKC), stimulation of MAP kinase (mitogen activated protein kinase/myelin basic protein kinase) and S6 kinase (ribosomal S6 protein kinase), regulation of the immune system and interaction with other elements and vitamins etc, suggesting that the roles of Se in human health may be more diverse than previously suspected.
Huang
Z
Z
Department of Biotech, Jinan University, Guangzhou 510632.
Xiang
J J
JJ
Guo
B J
BJ
D006801:Humans; D011506:Proteins / Q000502:physiology; D012643:Selenium / Q000502:physiology*; D017279:Selenocysteine / Q000502:physiology*; D051140:Selenoproteins; D013880:Thioredoxin-Disulfide Reductase / Q000502:physiology
D011506:Proteins; D051140:Selenoproteins; D017279:Selenocysteine; D013880:Thioredoxin-Disulfide Reductase; D012643:Selenium