[Effects of different disinfectants on levels of endotoxin in canals of chronic periapical periodontitis].
OBJECTIVE
The objective of this study is to compare effects of formocresol, camphorated phenol and Ya Kan (metronedazole) on endotoxin levels in canals of chronic periapical periodontitis.


METHODS
A total of 30 patients with chronic periapical periodontitis were selected from outpatients, and 10 cases each were randomly picked out to treat by sealing with formocresol, camphorated phenol and Ya Kan respectively. All patients were both sampled before and after sealing of these disinfectants, and chromogenic substrate method of limulus amebocyte lysate (LAL) test was used to measure levels of endotoxin.


RESULTS
The effects of Ya Kan, formocresol and camphorated phenol on levels of endotoxin did not showed significant difference.


CONCLUSIONS
Some anti-anaerobic bacterial drugs can be used to treat chronic periapical periodontitis.
Tan
H
H
College of Stomatology, West China University of Medical Sciences.
Hu
T
T
Xu
Y
Y
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D002164:Camphor / Q000494:pharmacology; D002908:Chronic Disease; D004338:Drug Combinations; D004731:Endotoxins / Q000032:analysis*; D005566:Formocresols / Q000494:pharmacology; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D010485:Periapical Periodontitis / Q000188:drug therapy*; D010636:Phenols / Q000494:pharmacology; D012388:Root Canal Irrigants
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D004731:Endotoxins; D005566:Formocresols; D010636:Phenols; D012388:Root Canal Irrigants; D008795:Metronidazole; C031025:formocresol; D002164:Camphor; C102651:camphorated phenol