title: p63 expression profile in normal and malignant prostate epithelial cells.
abstract: p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.
authors.affiliation: Center for Prostate Disease Research (CPDR), Department of Surgery, Uniformed Services University of the Health Sciences, 1530 East Jefferson Street, Rockville, MD 20852, USA.
authors.forename: Leland D
authors.initials: LD
authors.lastname: Davis
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Axel
authors.initials: A
authors.lastname: Merseburger
authors.forename: Denise
authors.initials: D
authors.lastname: Young
authors.forename: Linda
authors.initials: L
authors.lastname: Xu
authors.forename: Johng S
authors.initials: JS
authors.lastname: Rhim
authors.forename: Judd W
authors.initials: JW
authors.lastname: Moul
authors.forename: Shiv
authors.initials: S
authors.lastname: Srivastava
authors.forename: Isabell A
authors.initials: IA
authors.lastname: Sesterhenn
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators / Q000096:biosynthesis* / Q000235:genetics; D014157:Transcription Factors; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins