[Clindamycin soluble suppository-production and its efficacy in treating bacterial vaginosis].
OBJECTIVE
To make the soluble suppository of clindamycin which is an effective drug for treatment of Bacterial vaginosis and to treat patients in clinical trials.


METHODS
Outpatients who had vaginal infections from Sept. 1998 to Jan. 1999 were investigated. The diagnoses of bacterial vaginosis were made according to Amsel's criteria and 80 patients were included in this study. They were divided into two groups to be treated respectively by metronidanole suppository and clindamycin suppository which were made by our hospital pharmacy.


RESULTS
The cure rate of metronidanole was 87.5% and that of clindamycin 90.3%; No significant difference was noted between the two groups(P > 0.05). The new clindamycin suppository was not irritant and it was easy to dissolve in vagina. There was no discontinued treatment because of side-effect.


CONCLUSIONS
The clindamycin suppository does not irritate the mucosa of vagina, it is an efficacious remedy for bacterial vaginosis.
Huang
W
W
Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041, China.
Zhou
X
X
Huang
X
X
Peng
Y
Y
Su
Y
Y
Qiao
L
L
Zhou
S
S
Fang
F
F
Zhou
R
R
Li
S
S
Han
Z
Z
D000282:Administration, Intravaginal; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013488:Suppositories; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
D000890:Anti-Infective Agents; D013488:Suppositories; D002981:Clindamycin