High-throughput cell analysis using multiplexed array technologies.
The desire for more biologically relevant data from primary screening has resulted in a dramatic increase of cell-based assays in HTS labs. Consequently, new cell-array technologies are being developed to increase the quality and quantity of data emerging from such screens. These technologies take the form of both positional and non-positional formats, each with their own advantages. Notably, screens using these technologies generate databases of high-quality data that can be analyzed in ways currently not possible. The power of cell-based assays combined with new array and analytical technologies will enable the condensation of serial drug discovery processes, thereby decreasing the time and cost of taking a hit compound into clinical trials. Here, we compare array strategies being developed towards the goal of integrating multiplexed cell-based assays into HTS.
Beske
Oren E
OE
Virtual Arrays, 1190 Bordeaux Drive, Sunnyvale, CA 94089, USA.
Goldbard
Simon
S
D000818:Animals; D001681:Biological Assay; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends*; D006801:Humans; D040081:Protein Array Analysis / Q000379:methods / Q000639:trends*