Novel observation of a circular dichroism band originating from amyloid fibril.
A peptide fragment of a non-amyloid-beta component (NAC(1-13)) was studied by CD and electron microscopy. Typical amyloid fibrils were observed by EM in a solution of NAC(1-13). In addition to the beta-structural CD band in the far-UV region, a novel CD band near 285 nm was observed in a peptide solution of NAC(1-13). Taking the NAC(1-13) to contain neither an aromatic amino acid residue nor cystine into account, the CD band can be attributed to amyloid fibrils of NAC(1-13).
Abe
Hiroshi
H
Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, 1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Nakanishi
Hiroshi
H
D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000648:ultrastructure; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism / Q000379:methods*; D008854:Microscopy, Electron; D010446:Peptide Fragments / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000682:Amyloid; D010446:Peptide Fragments