Amygdala kindling in Proechimys guyannensis rat: an animal model of resistance to epilepsy.
OBJECTIVE
This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.


METHODS
Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.


RESULTS
From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4-5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1-3 and 5 and longer afterdischarge duration in stages 1-4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.


CONCLUSIONS
These findings suggest natural endogenous inhibitory mechanisms in this animal species.
de Amorim Carvalho
Reinaldo
R
Laboratório de Neurologia Experimental, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brasil.
Arida
Ricardo Mario
RM
Cavalheiro
Esper A
EA
D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D001931:Brain Mapping; D004195:Disease Models, Animal; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012377:Rodentia; D013045:Species Specificity