Effect of yiqitongyanghuatan recipe on experimental atherosclerosis in rabbits.
In order to investigate the roles of Yiqitongyanghuatan (YQTYHT) recipe in reducing the levels of serum cholesterol and plasma lipid peroxidation (LPO), platelet aggregation function (PAgF) and platelet adhesion function (PAdF), the area of atherosclerotic plague coverage in aorta and the thickness of plague, 32 male Japanese white rabbits were divided into 4 groups. The results showed that the YQTYHT recipe could significantly lower the levels of serum cholesterol and tryglyceride, plasma LPO, and PAgF and PadF. The area of atherosclerotic plague coverage in aorta and the thickness of plague in the YQTYHT-fed rabbits were decreased as compared with that in the high-cholesterol-fed rabbits. The above roles might contribute to the main mechanism of YQTYHT against atherosclerosis.
Huang
Z
Z
Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medeical College, Huazhong University of Science and Technology, Wuhan 430030.
Wu
H
H
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors