Pontine sources of norepinephrine in the cat cochlear nucleus.
In the current study, the distribution of noradrenergic neurons in the pontine tegmentum that project to the cochlear nucleus was determined with retrograde tract tracing combined with neurotransmitter immunohistochemistry in the cat. Double-labeled neurons were observed in all noradrenergic cell groups, in both the dorsolateral and the ventrolateral tegmentum. Half of the double-labeled cells were located in the locus coeruleus complex. Most of these were situated in its ventral division. Most other double-labeled cells were located in peribrachial regions, especially lateral to the brachium conjunctivum. Relatively few double-labeled cells were observed in both the A4 and the A5 cell groups, 2% and 0.4%, respectively, of the total. Except for neurons in A5, which projected only contralaterally, the projections were bilateral, with an ipsilateral preponderance. The results indicate that neurons located in the ipsilateral dorsolateral tegmentum, namely, in the locus coeruleus complex and the peribrachial region, are the primary source of pontine noradrenergic afferents to the cochlear nucleus of the cat.
Thompson
Ann M
AM
Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. ann-thompson@ouhsc.edu
D000320:Adrenergic Fibers / Q000737:chemistry; D000344:Afferent Pathways / Q000033:anatomy & histology*; D000818:Animals; D002415:Cats; D017626:Cochlear Nucleus / Q000033:anatomy & histology* / Q000737:chemistry*; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000033:anatomy & histology* / Q000737:chemistry; D009638:Norepinephrine / Q000032:analysis*; D011149:Pons / Q000033:anatomy & histology / Q000737:chemistry
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine