title: Adaptation to heat limits stress-induced activation of caspases in the thymus.
abstract: We demonstrated selective activation of caspases in the thymus during heat shock, i.e. primary activation of initiator caspase 9 (but not caspase 8) and effector caspase 3 (but not caspase 6). Preadaptation to heat improved animal survival after heat shock and reduced heat shock-induced activation of both initiator and effector caspases. Hence, adaptation to heat produced an antiapoptotic effect, which was not selective towards receptor-dependent or mitochondrial pathway of the caspase cascade activation.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Kruglov
authors.forename: L A
authors.initials: LA
authors.lastname: Baida
authors.forename: M G
authors.initials: MG
authors.lastname: Pshennikova
authors.forename: N P
authors.initials: NP
authors.lastname: Larionov
authors.forename: E B
authors.initials: EB
authors.lastname: Manukhina
authors.forename: I Yu
authors.initials: IY
authors.lastname: Malyshev
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D002457:Cell Extracts; D004789:Enzyme Activation; D006358:Hot Temperature; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000201:enzymology*; D013997:Time Factors
chemical_list: D002457:Cell Extracts; D020169:Caspases