[Determination of sildenafil in medicines for erectile dysfunction by capillary electrophoresis].
A method has been developed for the determination of sildenafil in the medicines for erectile dysfunction by capillary electrophoresis. The samples were analyzed with 60 mmol/L NaH2PO4(pH 5.0) running buffer at 35 degrees C capillary temperature and 30 kV voltage. A linear calibration was obtained from 0.07 g/L to 1.05 g/L of sildenafil (r = 0.9985) with the RSD of 4.7% for peak area, and the average recovery was 97.4%. The results were compared with those of HPLC, showing that the method is precise, simple and cost-effective, and can be used as a complementary method to HPLC.
Li
Run-kai
RK
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Bo
Tao
T
Liu
Hu-wei
HW
Li
Ke-an
KA
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D019587:Dietary Supplements / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D007172:Erectile Dysfunction; D006801:Humans; D008297:Male; D010879:Piperazines / Q000032:analysis*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000032:analysis
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate