title: A potent, water-soluble and photoinducible DNA cross-linking agent.
abstract: Water-soluble DNA cross-linking phenol and biphenol derivatives 3 and 6 have been synthesized by a Mannich reaction. Both of them can cross-link DNA by photoactivation using visible light (wavelength > 400 nm). Compound 6 can cross-link DNA at pH 5.0 and 7.7, whereas no cross-link was observed at pH 10.0. Density functional theory (DFT) calculation indicated that 6 displays a twist structure. Therefore, it could bind to DNA naturally and has potent property to cross-link DNA after photoactivation.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei Wuhan 430072, P. R. of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Renpeng
authors.initials: R
authors.lastname: Liu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wu
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ma
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Jiangye
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Weng
authors.forename: Xiao-Lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Linhong
authors.initials: L
authors.lastname: Weng
mesh_terms: D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D014867:Water; D004247:DNA