Endometritis does not predict reproductive morbidity after pelvic inflammatory disease.
OBJECTIVE
We investigated the association between endometritis and reproductive morbidity.


METHODS
Participants were 614 women in the PID Evaluation and Clinical Health (PEACH) Study with pelvic pain, pelvic organ tenderness, and leukorrhea, mucopurulent cervicitis, or untreated cervicitis. We compared women with endometritis (>or=5 neutrophils or >or=2 plasma cells), Neisseria gonorrhoeae or Chlamydia trachomatis upper genital tract infection (UGTI) or both to women without endometritis/UGTI for outcomes of pregnancy, infertility, recurrent pelvic inflammatory disease (PID), and chronic pelvic pain (CPP), adjusting for age, race, education, PID history, and baseline infertility.


RESULTS
Endometritis/UGTI was not associated with reduced pregnancy (odds ratio [OR] 0.8, 95% CI 0.6-1.2) or elevated infertility (OR 1.0, 95% CI 0.6-1.6), recurrent PID (OR 0.6, 95% CI 0.4-0.9), or CPP (OR 0.6, 95% CI 0.4-0.9). PEACH participants with and without endometritis/UGTI had higher age- and race-specific pregnancy rates than 1997 national rates.


CONCLUSIONS
Among women with clinically suspected mild-to-moderate PID treated with standard antibiotics, endometritis/UGTI was not associated with reproductive morbidity.
Haggerty
Catherine L
CL
University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261, USA. clcst10@pitt.edu
Ness
Roberta B
RB
Amortegui
Antonio
A
Hendrix
Susan L
SL
Hillier
Sharon L
SL
Holley
Robert L
RL
Peipert
Jeffrey
J
Randall
Hugh
H
Sondheimer
Steven J
SJ
Soper
David E
DE
Sweet
Richard L
RL
Trucco
Guiliana
G
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001421:Bacteria, Anaerobic; D001424:Bacterial Infections / Q000150:complications; D002440:Cefoxitin / Q000008:administration & dosage / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000150:complications; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004716:Endometritis / Q000150:complications*; D004717:Endometrium / Q000382:microbiology / Q000473:pathology; D005260:Female; D006069:Gonorrhea / Q000150:complications; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D016017:Odds Ratio; D000292:Pelvic Inflammatory Disease / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D011247:Pregnancy; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002440:Cefoxitin; D004318:Doxycycline; D011339:Probenecid