title: Relationships between coronary calcification detected at electron beam computed tomography and percutaneous transluminal coronary angioplasty results in coronary artery disease patients.
abstract: Our objective was to assess the relationship between coronary artery calcification and outcomes of percutaneous transluminal coronary angioplasty (PTCA). Electron beam computed tomography (EBCT) was performed in 80 patients with coronary artery disease (CAD) who underwent PTCA. The calcium score in each coronary artery vessel was estimated (in Agatston units) and compared with the occurrence of complications and restenosis. Angioplasty had been performed in 96 coronary artery segments with stenosis in 80 patients. The average calcium score in the unsuccessful PTCA segments was significantly higher than in ones with successful results. For complications these values were 65.0+/-79.9 and 27.0+/-44.7, respectively ( p=0.02), and for restenosis 63.9+/-87.9 and 27.3+/-41.3, respectively ( p=0.03). Applying receiver operating characteristics analysis we determined sensitivity and specificity of EBCT for forecasting complications and restenosis. The best cut-off value of calcium score in segment of PTCA for prediction of restenosis was 27 (sensitivity 73%, specificity 67%), and for prediction of complications 29 (sensitivity 80%, specificity 74%). Coronary segments with extensive calcification were not optimal target lesions for PTCA. Analysis of coronary calcium score should be taken into consideration during planning of endovascular coronary interventions.
authors.affiliation: Institute of Cardiology, Cardiology Research Center, 3d Cherepkovskaya Street, 15-A, 121552 Moscow, Russia. vsin@online.ru
authors.forename: V
authors.initials: V
authors.lastname: Sinitsyn
authors.forename: M
authors.initials: M
authors.lastname: Belkind
authors.forename: Y
authors.initials: Y
authors.lastname: Matchin
authors.forename: A
authors.initials: A
authors.lastname: Lyakishev
authors.forename: V
authors.initials: V
authors.lastname: Naumov
authors.forename: S
authors.initials: S
authors.lastname: Ternovoy
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D002114:Calcinosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D023903:Coronary Restenosis; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed