A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
BACKGROUND
Our understanding of genes that predispose to essential hypertension is poor.


METHODS
A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).


RESULTS
There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.


CONCLUSIONS
We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
Ranade
Koustubh
K
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA. koustubh.ranade@bms.com
Hinds
David
D
Hsiung
Chao Agnes
CA
Chuang
Lee-Ming
LM
Chang
Mau-Song
MS
Chen
Ying-Tsung
YT
Pesich
Robert
R
Hebert
Joan
J
Chen
Yii-Der I
YD
Dzau
Victor
V
Olshen
Richard
R
Curb
David
D
Botstein
David
D
Cox
David R
DR
Risch
Neil
N
D000328:Adult; D044466:Asian People; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007564:Japan / Q000208:ethnology; D008126:Lod Score; D008875:Middle Aged