title: [Effects of angiotensin II on proliferation and expression of interleukin-6 of human kidney fibroblasts].
abstract: OBJECTIVE
  To investigate the effects of Angiotensin(Ang) II on the proliferation and expression of Interleukin (IL)-6 in human kidney fibroblasts(KFB).
  
  
  METHODS
  The human KFB were cultured and identified, the proliferation of KFB was measured by MTT, and the level of IL-6 was measured by radioimmunoassay(RIA).
  
  
  RESULTS
  Angiotensin II could stimulate the proliferation of KFB and enhance the expression of IL-6 in protein level on KFB.
  
  
  CONCLUSIONS
  Angiotensin II can stimulate KFB's proliferation and enhance the expression of IL-6 of KFB. These findings suggest that Ang II might play a part in the mechanisms for modulating tubulointerstitial changes and induceing renal fibrosis.
authors.affiliation: Department of Nephrology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
authors.forename: S
authors.initials: S
authors.lastname: Qu
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Fang
authors.forename: G
authors.initials: G
authors.lastname: Chen
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005333:Fetus; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D007668:Kidney / Q000166:cytology*
chemical_list: D015850:Interleukin-6; D000804:Angiotensin II