title: Effects of Livagen peptide on chromatin activation in lymphocytes from old people.
abstract: We studied the effects of the synthetic peptide Livagen on activity of ribosomal genes, denaturation parameters of heterochromatin, polymorphism of structural C-heterochromatin, and variability of facultative heterochromatin in lymphocytes from old people. Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Tbilisi, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: T A
authors.initials: TA
authors.lastname: Lezhava
authors.forename: J G
authors.initials: JG
authors.lastname: Monaselidze
authors.forename: T A
authors.initials: TA
authors.lastname: Dzhokhadze
authors.forename: N A
authors.initials: NA
authors.lastname: Dvalishvili
authors.forename: N K
authors.initials: NK
authors.lastname: Bablishvili
authors.forename: I Yu
authors.initials: IY
authors.lastname: Ryadnova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism*; D002877:Chromosomes, Human / Q000187:drug effects / Q000378:metabolism; D002878:Chromosomes, Human, Pair 1 / Q000187:drug effects / Q000378:metabolism; D002885:Chromosomes, Human, Pair 16 / Q000187:drug effects / Q000378:metabolism; D002899:Chromosomes, Human, Pair 9 / Q000187:drug effects / Q000378:metabolism; D006570:Heterochromatin / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000378:metabolism; D009841:Oligonucleotides / Q000494:pharmacology*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D012834:Silver / Q000378:metabolism; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013194:Staining and Labeling
chemical_list: D002843:Chromatin; D006570:Heterochromatin; C473185:Livagen; D009841:Oligonucleotides; D009842:Oligopeptides; D010455:Peptides; D012834:Silver