Diaryloxyacetate herbicides.
The discovery and investigation of a novel family of herbicides containing a diaryl acetal are described. The stability of the acetal limited herbicidal efficacy and recognizing that fact led to the design of analogs with commercial levels of post-emergence activity on broadleaf weeds. These compounds inhibited acetolactate synthase and in vitro activity data were used to guide target design. However, no members of this family provided a commercially valuable combination of herbicidal efficacy and crop selectivity.
Smith
Michael G
MG
Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, USA.
Lo
William C
WC
Jacks
Wendy
W
Moore
Susan
S
Pernich
Daniel J
DJ
Subramanian
Mani V
MV
Turner
James A
JA
D000095:Acetolactate Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006540:Herbicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D015394:Molecular Structure; D010944:Plants / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
D006540:Herbicides; D000095:Acetolactate Synthase