Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins.
Proteins may serve as ideal CD8(+) T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols.
Huang
Xiao-Li
XL
Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
Fan
Zheng
Z
Zheng
Lian
L
Borowski
Luann
L
Li
Hongyi
H
Thomas
Elaine K
EK
Hildebrand
William H
WH
Zhao
Xiao-Qing
XQ
Rinaldo
Charles R
CR
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology; D023201:CD40 Ligand; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D015488:HIV Antigens / Q000008:administration & dosage / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008081:Liposomes; D008213:Lymphocyte Activation; D010714:Phosphatidylethanolamines
D016915:AIDS Vaccines; D015488:HIV Antigens; D008081:Liposomes; D010714:Phosphatidylethanolamines; D023201:CD40 Ligand; C020888:1,2-dielaidoylphosphatidylethanolamine