Three-dimensional structure of the transthyretin-retinol-binding protein complex.
Transthyretin (TTR), formerly called prealbumin, one of the transporters of the hormone thyroxine and retinol-binding protein (RBP), the specific carrier of vitamin A, forms, under physiological conditions, a macromolecular complex that prevents glomerular filtration of the low-molecular-weight RBP in the kidneys. This paper describes briefly the three-dimensional structure of the two proteins as determined by X-ray diffraction analysis of single crystals and that of the complex that the two molecules form in plasma and discusses the non-crystallographic evidence that supports the model of the macromolecular complex.
Monaco
Hugo L
HL
Department of Science and Technology, Biocrystallography Laboratory, University of Verona, Verona, Italy. monaco@sci.univr.it
D000595:Amino Acid Sequence; D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011228:Prealbumin / Q000737:chemistry*; D020836:Protein Structure, Quaternary; D017433:Protein Structure, Secondary; D012177:Retinol-Binding Proteins / Q000737:chemistry*; D054839:Retinol-Binding Proteins, Plasma
D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma