title: Nutritional support in pediatric patients undergoing bone marrow transplantation.
abstract: BACKGROUND
  Children undergoing bone marrow transplantation (BMT) are prone to develop severe gastrointestinal (GI) complications and metabolic imbalance which consequently impair their nutritional status. Nutritional support is an important adjunctive treatment during BMT.
  
  
  OBJECTIVE
  To assess GI complications, metabolic complications and nutritional outcome of children undergoing BMT with nutritional support intervention.
  
  
  METHODS
  Retrospective study of 20 children (median age 6.8 years, 11 males) undergoing BMT at Ramathibodi Hospital from March 1995 to July 2000 was conducted. Their medical records were reviewed.
  
  
  RESULTS
  The patients underwent autologous (n = 9) and allogenic BMT (n = 11). Median z-scores of weight for age, height for age and weight for height were 0.06 +/- 1.93, -0.55 +/- 1.18 and 0.48 +/- 1.94, respectively. Nineteen patients had vomiting for 9.8 +/- 5.5 days. Eighteen patients developed diarrhea for 9.6 +/- 7.2 days. The durations of vomiting and diarrhea, as a percentage of total hospital days, were 33.5 +/- 16.3 per cent and 30.4 +/- 17.0 per cent, respectively. There were no differences between the patients with autologous and allogenic BMT regarding these durations. All patients needed enteral and/or parenteral nutrition support for 21.0 +/- 7.7 days except for one patient who could take adequate oral intake. The duration of enteral nutrition support was not significantly different between the groups but the duration of parenteral nutrition support was significantly longer in the allogenic group. Metabolic complications were hypokalemia, hypophosphatemia and one case of arrhythmia secondary to hypomagnesemia. All patients developed febrile neutropenia but none developed catheter-related sepsis. The length of hospital stay was 30.5 +/- 10.2 days. The median z-score of weight for height on the day of discharge was 1.08 +/- 2.03.
  
  
  CONCLUSIONS
  Children undergoing BMT usually have GI symptoms of vomiting, diarrhea and mucositis as well as metabolic imbalances such as hypokalemia, hypophosphatemia and hypomagnesemia. Despite these complications, their nutritional status could be restored by proper nutritional support.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Vijitr
authors.initials: V
authors.lastname: Isariyavuth
authors.forename: Umaporn
authors.initials: U
authors.lastname: Suthutvoravut
authors.forename: Suthida
authors.initials: S
authors.lastname: Chatvuttinun
authors.forename: Vinita
authors.initials: V
authors.lastname: Chantraruksa
authors.forename: Ruchada
authors.initials: R
authors.lastname: Kasemsup
authors.forename: Somporn
authors.initials: S
authors.lastname: Krasaesub
authors.forename: Suradej
authors.initials: S
authors.lastname: Hongeng
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology* / Q000628:therapy*; D009752:Nutritional Status; D018529:Nutritional Support; D012189:Retrospective Studies