[Effect of dextran combination with flurosemide on nephrotic syndrome].
OBJECTIVE
To compare the diuretic effect of coadministration of dextran and flurosemide with that of coadministration of Albumin and flurosemide on primary nephrotic syndrome.


METHODS
In a double-blind placebo-controlled study, eighteen primary nephrotic syndrome patients on standard sodium chloride intake, random by divided into three groups and received by intravenous administration for 60 minutes for three days (a) FU (1 mg.kg-1) combination with a sham infusion, (b) FU (1 mg.kg-1) combination with 50 ml of 20% solution of Albumin, or (c) FU (1 mg/kg) combination with 250 ml dextran 40. Urinary volume, sodium and plasma atrial nartiuretic peptide concentration were assessed.


RESULTS
The results showed that administration of FU alone increased mean cumulative urinary sodium and volume excretion as compared with the administration of sham infusion without treatment (P < 0.05). The administration of FU and albumin or FU and dextran 40 caused an even more marked increase of urinary sodium and volume excretion (P < 0.01), as compared with the administration of sham infusion without treatment. Plasma ANP increased significantly on both albumin infusion days and dextran 40 infusion days (P < 0.05).


CONCLUSIONS
Coadministration of albumin and FU or dextran 40 and FU can increase the urinary volume and urinary Na and ANP significantly, dextran 40 can take the place of albumin because there was no difference between the administration of FU and albumin and FU and dextran in UV, Una and ANP.
Chen
X
X
Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Liu
H
H
Ma
Z H
ZH
D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D003911:Dextrans / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D010952:Plasma Substitutes / Q000627:therapeutic use*
D003911:Dextrans; D004232:Diuretics; D010952:Plasma Substitutes; D005665:Furosemide; D009320:Atrial Natriuretic Factor