title: Direct organocatalytic aldol reactions in buffered aqueous media.
abstract: Organocatalytic cross-aldol reactions catalyzed by cyclic secondary amines in aqueous media provide a direct route to a variety of aldols including carbohydrate derivatives and may warrant consideration as a prebiotic route to sugars.
authors.affiliation: Skaggs Institute for Chemical Biology, Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Notz
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Barbas
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002021:Buffers; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007659:Ketones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D002021:Buffers; D007659:Ketones