title: Interleukin-10 levels in Epstein-Barr virus-associated nasopharyngeal carcinoma.
abstract: The aim of this study was to determine the levels of interleukin-10 in patients with nasopharyngeal carcinoma. Both biopsies and sera were obtained from patients with nasopharyngeal carcinoma as well as Epstein-Barr virus-seronegative patients as a control. Nasopharyngeal carcinoma patients were classified using the World Health Organization pathological assessment and clinical staging of nasopharyngeal carcinoma. The numbers of interleukin-10 positive cells and the levels of serum interleukin-10 were assessed by immunohistochemical methods and enzyme-linked immunosorbent assay, respectively. The levels of serum interleukin-10 were determined by enzyme-linked immunosorbent assay. The results showed that the number of interleukin-10 positive cells and serum interleukin-10 levels were significantly increased in patients with nasopharyngeal carcinoma-World Health Organization type III and with clinical late stage (p<0.05), suggesting that interleukin-10 may have a crucial role in the progression of nasopharyngeal carcinoma.
authors.affiliation: Department of Biology, Faculty of Mathematics and Natural Science, Sumatera Utara University, Medan, Sumatera Utara, Indonesia.
authors.forename: Dyah R
authors.initials: DR
authors.lastname: Budiani
authors.forename: Salomo
authors.initials: S
authors.lastname: Hutahaean
authors.forename: Sofia M
authors.initials: SM
authors.lastname: Haryana
authors.forename: Marsetyawan H N E
authors.initials: MH
authors.lastname: Soesatyo
authors.forename: Wihaskoro
authors.initials: W
authors.lastname: Sosroseno
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000821:virology*
chemical_list: D016753:Interleukin-10