title: [Effect of danggui buxue decoction on proliferation and expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells].
abstract: OBJECTIVE
  To investigate the effect of Danggui Buxue Decoction (DBD) on proliferation and expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs).
  
  
  METHODS
  After treating HUVECs with various concentrations of DBD, we analyzed the proliferation phase of HUVECs and the expression of ICAM-1 using flow cytometry.
  
  
  RESULTS
  It was found that DBD could promote the proliferation of HUVECs and the expression of ICAM-1. The expression of CD54 (ICAM-1) was significantly increased in the experiment groups as compared with that in the control group (P < 0.05). In addition, cell cycle analysis revealed more synthetic period cells in the experiment groups than in control group (P < 0.05).
  
  
  CONCLUSIONS
  DBD can promote the proliferation of HUVECs and Increase the expression ICAM-1.
authors.affiliation: Department of Histology and Embryology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: B
authors.initials: B
authors.lastname: Zhu
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D027885:Astragalus propinquus / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006397:Hematinics / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006397:Hematinics; D018799:Intercellular Adhesion Molecule-1