[Changes in plasma concentration of interleukin-6 in elderly patients with coronary artery disease complicated with heart failure].
OBJECTIVE
The aim of this study was to observe the concentrations of plasma interleukin-6(IL-6) in elderly patients with coronary artery disease(CAD).


METHODS
Forty-eight CAD patients with heart failure, 15 CAD patients without heart failure, and 30 normal subjects were studied. The plasma concentration of interleukin-6(IL-6) was measured by enzyme-linked immunosorbent assay.


RESULTS
The plasma concentration of IL-6 in CAD patients with heart failure was significantly higher than that without heart failure and normal subjects, respectively (P < 0.05). There was no significant difference between CAD patients without heart failure and normal subjects in the plasma levels of IL-6. There was a negative correlation between the concentration of IL-6 and left ventricular ejection fraction(LVEF) (r = -0.60, P < 0.01). The plasma concentration of IL-6 of the group with re-hospitalization because of severe heart failure was significantly higher than that of the group without hospital readmission (P < 0.01).


CONCLUSIONS
The plasma concentration of IL-6 in CAD patients with heart failure may provide the important information for the severity of the disease and for the prognostic prediction in the disease.
Wang
X Q
XQ
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jian
Z J
ZJ
Xie
J C
JC
D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D015850:Interleukin-6