title: [Protective effect of berberine on isolated perfused heart in heart failure].
abstract: OBJECTIVE
  To examine the protective action of berberine against the development of heart failure.
  
  
  METHODS
  Wister rats were divided into two groups. The Langendorff perfusion of isolated heart was performed and Verapamil was used to bring about acute heart failure. The experiment group was given berberine (10(-6) mol/L) before the use of Verapamil, but the control group was not given the berberine. A comparison was made on the degree of heart failure between the two group.
  
  
  RESULTS
  The degree of heart failure in the experiment group was significantly less severe than that in the control group (P < 0.001).
  
  
  CONCLUSIONS
  Berberine has the protective action against to the development of heart failure.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Lan
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002303:Cardiac Output, Low / Q000139:chemically induced / Q000517:prevention & control; D066298:In Vitro Techniques; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil
chemical_list: D002120:Calcium Channel Agonists; D020011:Protective Agents; D001599:Berberine; D014700:Verapamil