Gabapentin for the treatment of tremor.
OBJECTIVE
To review the use of the antiepileptic drug gabapentin for the treatment of various types of tremor.


METHODS
A search of biomedical literature was completed through MEDLINE and EMBASE (1993-May 2002) to identify all clinical trials pertaining to the use of gabapentin for the treatment of tremor in humans.


RESULTS
Outcome data from the few published studies have varied widely. Patient groups have been small, and conclusions have been based largely on subjective patient and investigator ratings.


CONCLUSIONS
A trial of gabapentin is warranted in patients who fail therapy with traditional agents. Improvement should be measured by a patient's perceived functional ability.
Faulkner
Michele A
MA
School of Pharmacy and Allied Health Professions, Creighton University, Omaha, NE 68178-0401, USA. faulkner@creighton.edu
Bertoni
John M
JM
Lenz
Thomas L
TL
D000085:Acetates / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000588:Amines; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D016896:Treatment Outcome; D014202:Tremor / Q000145:classification / Q000188:drug therapy* / Q000209:etiology; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin