title: [Detection of genomic instability in offspring of male mice chronically exposed to gamma-radiation by the "adaptive response" test].
abstract: The genomic instability (GI) in somatic cells of the progeny (F1 generation) of male mice chronically exposed to low-dose gamma-radiation was studied by comparative analysis of chromosome damage. BALB/C male mice exposed to 0.1 Gy (0.01 Gy/day) and 0.5 Gy (0.01 and 0.05 Gy/day) were mated with unirradiated females 15 days after irradiation. For comparison of radiosensitivity, two-month-old males, the descendants of irradiated and unirradiated animals, were subjected to irradiation with a dose of 1.5 Gy (0.47 Gy/min) from a 60Co source. GI was revealed by the standard scheme of adaptive response. The experiments indicated that, by using the test "adaptive response", it is possible to detect the transition of gamma-radiation-induced genomic instability in sex cells of male parent into somatic cells of mice (F1 generation) either from changes in radiosensitivity or by the absence of the adaptive response induced by a standard scheme.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia. Zaichkina@mail.ru
authors.forename: S I
authors.initials: SI
authors.lastname: Zanchkina
authors.forename: O M
authors.initials: OM
authors.lastname: Rozanova
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Akhmadieva
authors.forename: G F
authors.initials: GF
authors.lastname: Aptikaeva
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Klokov
authors.forename: E N
authors.initials: EN
authors.lastname: Smirnova
authors.forename: M E
authors.initials: ME
authors.lastname: Zaichkin
authors.forename: V E
authors.initials: VE
authors.lastname: Balakin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018812:Paternal Exposure