Morton Medal Lecture. New insights into the roles of phosphoinositides and inositol polyphosphates in yeast.
During the past half century, we have progressed from simply viewing myo -inositol-containing glycerophospholipids as quantitatively minor membrane constituents to the present, very striking, situation in which more and more important cellular functions are being assigned to a plethora of phosphorylated derivatives of inositol and phosphatidylinositol. Two such examples are discussed briefly: the activation by environmental stresses of the single phosphoinositidase C of yeast, which is related to the phospholipase C delta s of other eukaryotes, and the involvement of PtdIns(3,5) P (2) in endomembrane trafficking.
Michell
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RH
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. r.h.mitchell@bham.ac.uk
Perera
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NM
Dove
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SK
D004789:Enzyme Activation; D007295:Inositol Phosphates / Q000502:physiology*; D008956:Models, Chemical; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000502:physiology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism*; D013997:Time Factors
D007295:Inositol Phosphates; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C106336:phosphatidylinositol 3,5-diphosphate; D010727:Phosphoric Diester Hydrolases; C021491:glycerophosphoinositol glycerophosphodiesterase