title: Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report.
abstract: This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fridell
authors.forename: Ashok Kumar B
authors.initials: AK
authors.lastname: Jain
authors.forename: Kusum
authors.initials: K
authors.lastname: Patel
authors.forename: Mohamed
authors.initials: M
authors.lastname: Virji
authors.forename: K N
authors.initials: KN
authors.lastname: Rao
authors.forename: John J
authors.initials: JJ
authors.lastname: Fung
authors.forename: Raman
authors.initials: R
authors.lastname: Venkataramanan
mesh_terms: D019540:Area Under Curve; D004347:Drug Interactions; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D016031:Liver Transplantation / Q000706:statistics & numerical data; D008875:Middle Aged; D010672:Phenytoin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D020123:Sirolimus / Q000097:blood* / Q000627:therapeutic use
chemical_list: D010672:Phenytoin; D020123:Sirolimus