title: Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina.
abstract: The toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase II detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication.
authors.affiliation: Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Beattie
authors.forename: Judith
authors.initials: J
authors.lastname: Ressler
authors.forename: Claudia
authors.initials: C
authors.lastname: Wiegand
authors.forename: Eberhard
authors.initials: E
authors.lastname: Krause
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Codd
authors.forename: Christian E W
authors.initials: CE
authors.lastname: Steinberg
authors.forename: Stephan
authors.initials: S
authors.lastname: Pflugmacher
mesh_terms: D000818:Animals; D001156:Artemia / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism* / Q000633:toxicity; D000458:Cyanobacteria / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D008658:Inactivation, Metabolic; D008387:Marine Toxins / Q000378:metabolism / Q000633:toxicity; D052998:Microcystins; D010456:Peptides, Cyclic / Q000378:metabolism / Q000633:toxicity
chemical_list: D001427:Bacterial Toxins; D004791:Enzyme Inhibitors; D008387:Marine Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; C063998:nodularin; C078588:microcystin; D005982:Glutathione Transferase; C057862:cyanoginosin LR; D005978:Glutathione