Antiphospholipid antibodies in young women with and without oral contraceptive use.
The role of thrombophilia in the elevated risk of thromboembolism during oral contraceptive use has been established. We performed a cross-sectional study among young women to survey the occurrence of antiphospholipid antibodies among users and non-users of oral contraceptives. Serum levels of immunoglobulin (Ig)G, IgA and IgM isotypes of anti-beta2-glycoprotein I and anticardiolipin antibodies were measured by validated enzyme-linked immunosorbent assay methods. Combining all types of antiphospholipid antibodies, pill-users had an elevated antibody titre more than twice as frequently as non-users (odds ratio, 2.3; 95% confidence interval, 1.1-5.1). The higher frequency of elevated antibody titre was related most commonly to IgG type anti-beta2-glycoprotein I antibodies. Oral contraceptive use increases the risk of elevated antiphospholipid antibody levels among asymptomatic young women.
Vad
Szilvia
S
Department of Obstetrics and Gynaecology, University of Debrecen Health Science Centre, Debrecen, Hungary.
Lakos
Gabriella
G
Kiss
Emese
E
Sipka
Sàndor
S
Csorba
Roland
R
Poka
Robert
R
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000187:drug effects; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000187:drug effects; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D003276:Contraceptives, Oral / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood / Q000187:drug effects; D016017:Odds Ratio; D011446:Prospective Studies; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D003276:Contraceptives, Oral; D006023:Glycoproteins; D007132:Immunoglobulin Isotypes; D053482:beta 2-Glycoprotein I