title: Novel dic(16;18)(q11;p11) in two cases of Philadelphia chromosome positive acute B-cell lymphoblastic leukemia.
abstract: We report two adult patients with Philadelphia chromosome positive (Ph+) B-cell acute lymphoblastic leukemia (ALL) who presented an additional dic(16;18)(q11;p11) that, to the best of our knowledge, has never been previously reported. Fluorescence in situ hybridization analysis confirmed the translocation and showed it to be dicentric. Both patients were treated for the ALL, but showed refractory disease and died despite aggressive treatment. Similarly to what has been reported with other additional chromosome abnormalities, our cases suggest that the presence of this novel translocation confers an adverse effect to the already poor prognosis of Ph+ ALL.
authors.affiliation: Department of Hematology and Cytology, Institut Català d'Oncologia, Ciudad Sanitaria y Universitaria de Bellvitge, Barcelona, Spain. 31577edd@comb.es
authors.forename: Eva
authors.initials: E
authors.lastname: Domingo-Domènech
authors.forename: Concha
authors.initials: C
authors.lastname: Boqué
authors.forename: Ana
authors.initials: A
authors.lastname: Aventin
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Calasanz
authors.forename: Alberto
authors.initials: A
authors.lastname: Valiente
authors.forename: Katy
authors.initials: K
authors.lastname: Perez-Equiza
authors.forename: Alicia
authors.initials: A
authors.lastname: Domingo-Clarós
authors.forename: Albert
authors.initials: A
authors.lastname: Grañena
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male