Elevation of histidine decarboxylase activity in the stomach of mice by ulcerogenic drugs.
Histamine is involved in the development of gastric lesions. To examine the contribution of the histamine-forming enzyme, histidine decarboxylase, to drug-induced gastric lesions, we compared the effects of aspirin, indomethacin and dexamethasone on histidine decarboxylase activity in mice. Administration of these drugs, orally or intraperitoneally, elevated histidine decarboxylase activity in the stomach but not in the liver, lung or spleen, dexamethasone being the most potent. In contrast, acetaminophen (a non-ulcerogenic drug) was inactive. These results and our previously reported findings (elevation of histidine decarboxylase activity by lipopolysaccharide, interleukin-1 and tumour necrosis factor, and by different types of stress) suggest that an elevation of histidine decarboxylase activity in the stomach may be a common feature of the responses to ulcerogenic stimuli. The possible participation of histidine decarboxylase in gastric lesions is discussed on the basis of the known actions of histamine, our findings and the effect of histamine H(2) receptor antagonists on histidine decarboxylase activity.
Ayada
Kentaro
K
Department of Pharmacology, Graduate School of Dentistry, Tohoku University, 4-l Seiryo-machi, Aoba-ku, Sendai 980, Japan.
Oguri
Senri
S
Yamaguchi
Kouji
K
Kumagai
Katsuo
K
Endo
Yasuo
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D006640:Histidine Decarboxylase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013270:Stomach / Q000187:drug effects* / Q000201:enzymology*; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000201:enzymology*
D006640:Histidine Decarboxylase