AFM imaging of calixarene based solid lipid nanoparticles in gel matrices.
Contact mode atomic force microscopy has been carried out on gels of four current polymers, carbopol 980, carbopol 2020, hyaluronic acid and xanthan containing dispersions of solid lipid nanoparticles (SLNs) of amphiphilic calixarenes. Imaging shows that the SLNs are dispersed within the gels as discrete particles of 150nm in diameter and show little or no aggregation. The simultaneous use of lateral force, topographic and force modulation mode imaging allows a clear interpretation of the observed images, showing the presence of nanoparticles in the sub-surface region and that the SLNs affect the local mechanical properties of the gels. Photon correlation spectroscopy similarly demonstrates a lack of interaction in suspensions.
Shahgaldian
Patrick
P
Institut de Biologie et Chimie des Protéines, Lyon, France.
Quattrocchi
Laurence
L
Gualbert
Jérôme
J
Coleman
Anthony W
AW
Goreloff
Philippe
P
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D047250:Calixarenes; D005079:Excipients / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D010316:Particle Size; D010636:Phenols / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry
C477442:4-dodecanoylcalix(4)arene; D001952:Bridged-Ring Compounds; D005079:Excipients; D005782:Gels; D010636:Phenols; D011135:Polysaccharides, Bacterial; C121325:calix(4)arene; D047250:Calixarenes; D006820:Hyaluronic Acid; C002563:xanthan gum