title: Synthesis of 2'-deoxy-2'-fluoroguanyl-(3',5')-guanosine.
abstract: The protected analogue of 2-amnio-6-chloropurine arabinoside (3b) was subjected to reaction with diethylaminosulfur trifluoride (DAST) and subsequently treated with NaOAc in Ac2O/AcOH to give N2, O3', O5'-triacetyl-2'-deoxy-2'-fluoroguanosine (5a). After deacetylation of the sugar moiety and protection of 5'-OH by a 4,4'-dimethoxytrityl group, this nucleoside component was converted to 2'-deoxy-2'-fluoroguanyl-(3',5')-guanosine (6c, GfpG).
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. maruyama@ph.bunri-u.ac.jp
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
authors.forename: Shigetada
authors.initials: S
authors.lastname: Kozai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masachika
authors.initials: M
authors.lastname: Irie
mesh_terms: D015195:Drug Design; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C476876:2'-deoxy-2'-fluoroguanyl-(3',5')-guanosine; D006151:Guanosine