title: [Expression and significance of urokinase-type plasminogen activator in medulloblastoma].
abstract: OBJECTIVE
  To detect the expression and evaluate the clinical significance of urokinase-type plasminogen activator (uPA) in medulloblastoma.
  
  
  METHODS
  LSAB (labelled streptavidin biotin method) immunohistochemical technique was applied for detecting the expression of uPA in 50 patients with medulloblastoma, and a follow-up survey with Cox regression analysis was made.
  
  
  RESULTS
  The staining for uPA was localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA was an independent prognostic factor affecting survival and it had a negative correlation with the prognosis.
  
  
  CONCLUSIONS
  uPA appears to be an independent marker for predicting the prognosis of medulloblastoma.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Mao
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000201:enzymology*; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014568:Urokinase-Type Plasminogen Activator