title: [Simple preparation and evaluations of amide-octyl-bonded phase].
abstract: A simple preparation process of amide-octyl-bonded phase (AOBP) is described. In the process aminopropyltriethoxysilane first reacted with octanoyl chloride and then the obtained intermediate was bonded onto porous silica. Characterization of prepared packing was carried out with elemental analysis, solid-state nuclear magnetic resonance (13C-NMR) and Fourier transform infrared (FTIR) spectroscopy. Chromatographic evaluations were carried out by testing with a mixture including acidic, basic and neutral organic compounds using methanol-water as binary mobile phase. The results show that the stationary phase has excellent chromatographic properties and resistance to hydrolysis between pH 2.5-7.5. It can be used for the efficient separation of basic compounds.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012, China.
authors.forename: Xiao-jia
authors.initials: XJ
authors.lastname: Huang
authors.forename: Jun-de
authors.initials: JD
authors.lastname: Wang
authors.forename: Xue-liang
authors.initials: XL
authors.lastname: Liu
authors.forename: Run-zi
authors.initials: RZ
authors.lastname: Cong
mesh_terms: D020003:1-Octanol / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010208:Papaverine / Q000302:isolation & purification; D010546:Perphenazine / Q000302:isolation & purification; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000577:Amides; D011437:Propylamines; D012821:Silanes; C088294:3-aminopropyltrimethoxysilane; D012822:Silicon Dioxide; D010208:Papaverine; D010546:Perphenazine; D020003:1-Octanol