title: Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
abstract: The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological response profile. Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor.
authors.affiliation: Department of Pharmacological Sciences, University of Milan, Italy.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Abbracchio
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Boeynaems
authors.forename: Eric A
authors.initials: EA
authors.lastname: Barnard
authors.forename: José L
authors.initials: JL
authors.lastname: Boyer
authors.forename: Charles
authors.initials: C
authors.lastname: Kennedy
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Miras-Portugal
authors.forename: Brian F
authors.initials: BF
authors.lastname: King
authors.forename: Christian
authors.initials: C
authors.lastname: Gachet
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson
authors.forename: Gary A
authors.initials: GA
authors.lastname: Weisman
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000502:physiology; D006801:Humans; D043562:Receptors, G-Protein-Coupled; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D058470:Receptors, Purinergic P2Y; D014532:Uridine Diphosphate Glucose / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D018048:Receptors, Purinergic P2; D058470:Receptors, Purinergic P2Y; D014532:Uridine Diphosphate Glucose; C518528:P2Y14 receptor, human