[Elementary events and characteristics of calcium signalling].
There are many different elementary intracellular calcium signalling in the cell. These events appear to have a hierarchical organization depending on stimulus intensity. Low levels of stimulation activate individual channels such as the blips or quarks; The next level of organization is the puffs and sparks, which appear to be derived from small clusters of channels. At high stimulus intensities these elementary events are coordinated to give global events. These events not only present the character of Ca2+ release unit, also lead to different complex spatiotemporal organization of calcium signalling, emphasizing the hierarchical organization and local control model of calcium signalling.
Zhang
S Y
SY
Institute of Respiratory of New Bridge Hospital, Third Military Medical College, Chongqing 400037.
Guo
X J
XJ
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology; D015398:Signal Transduction
D015220:Calcium Channels; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium