[Toxicity of microcystin and its bioaccumulation effect].
Microcystins are cyclic heptapeptide hepatotoxins from certain cyanobacteria. It can inhibit hepatic protein phosphatase 1 and 2A activities, break the balance between protein phosphorylation and phosphorylysis, causing liver damage even necrocytosis. Furthermore, it is a strong tumor promoter. Yet, its hazard received little study. This paper presents a latest review of toxicity and bioaccumulation of Microcystins.
Sui
Haixia
H
Institute of Food Safety Control and Inspection, Ministry of Health, Beijing 100021, China.
Yan
Weixing
W
Xu
Haibin
H
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity; D000458:Cyanobacteria / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism; D006801:Humans; D052998:Microcystins; D010456:Peptides, Cyclic / Q000633:toxicity*; D014873:Water Pollutants / Q000032:analysis*
D001427:Bacterial Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; D014873:Water Pollutants; C078588:microcystin