title: RNAi hushes heterochromatin.
abstract: Repeated DNA elements and region-specific protein modifications combine within chromosomes to form a transcriptionally silent chromatin structure called heterochromatin. Recent work in the fission yeast Schizosaccharomyces pombe reveals that RNA is also an integral component of silent heterochromatin, providing a new perspective on how heterochromatin is organized and maintained in eukaryotic cells.
authors.affiliation: Molecular and Cellular Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Bailis
authors.forename: Susan L
authors.initials: SL
authors.lastname: Forsburg
mesh_terms: D000818:Animals; D020868:Gene Silencing; D006570:Heterochromatin / Q000235:genetics*; D008957:Models, Genetic; D016372:RNA, Antisense / Q000235:genetics*; D034741:RNA, Small Interfering
chemical_list: D006570:Heterochromatin; D016372:RNA, Antisense; D034741:RNA, Small Interfering