Reversal of left ventricular remodeling: role of the endothelin pathway.
Left ventricular remodeling is the result of multiple interrelated processes that evolve through time. The contribution of neurohormones to these processes has been recognized and has lead to important therapeutic advances. Endothelin is a recently discovered neurohormone that has many properties that suggest an important role in the pathophysiology of ventricular remodeling. This review discusses this role of the endothelin pathway in the development of left ventricular remodeling and the evidence that endothelin antagonists can reverse this deleterious process.
Teerlink
John R
JR
University of California and the Heart Failure Clinic, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA.
D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D020257:Ventricular Remodeling / Q000502:physiology*
D065128:Endothelin Receptor Antagonists; D016232:Endothelins