A mechanosensitive cation channel in endothelial cells.
A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.
Yao
Xiaoqiang
X
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. yao2068@cuhk.edu.hk
Kwan
H Y
HY
Huang
Yu
Y
D001685:Biological Factors / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism
D001685:Biological Factors; D015220:Calcium Channels; C067410:endothelium-dependent hyperpolarization factor; D009569:Nitric Oxide; D011464:Epoprostenol