Interaction of sertraline with Candida species selectively attenuates fungal virulence in vitro.
This study investigated whether the interaction between isolates of Candida albicans (n=7), Candida parapsilosis (n=3), Candida krusei (n=2), Candida dubliniensis (n=1) and sertraline, a typical selective serotonin reuptake inhibitor, alters candidal virulence. Sertraline treatment of Candida spp. significantly (P<0.05) affected hyphal elongation, phospholipase activity, production of secreted aspartyl proteinases and fungal viability. In addition, monocyte-derived macrophages (MDMs) treated with sertraline reduced inhibition of blastoconidia germination in comparison to MDMs alone. In conclusion, our findings suggest that the interaction between sertraline and Candida spp. may also diminish the virulence properties of this fungal pathogen in vivo.
Lass-Flörl
Cornelia
C
Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Str. 3, 6020 Innsbruck, Austria. cornelia.lass-floerl@uibk.ac.at
Ledochowski
Maximilian
M
Fuchs
Dietmar
D
Speth
Cornelia
C
Kacani
Laco
L
Dierich
Manfred P
MP
Fuchs
Anita
A
Würzner
Reinhard
R
D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity*; D002176:Candida albicans / Q000254:growth & development / Q000472:pathogenicity; D002478:Cells, Cultured; D006801:Humans; D008264:Macrophages / Q000737:chemistry / Q000382:microbiology*; D009000:Monocytes / Q000737:chemistry / Q000382:microbiology*; D010740:Phospholipases / Q000037:antagonists & inhibitors; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline / Q000494:pharmacology*; D014774:Virulence
D016282:Aspartic Acid Endopeptidases; D010740:Phospholipases; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline