[Analysis of the metabolite of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in rabbit].
OBJECTIVE
To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13, 13a-tetrahydroberberine in the rabbit.


METHODS
Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR.


RESULTS
A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated.


CONCLUSIONS
Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
Feng
N P
NP
China Pharmaceutical University, Nanjing 210009, China. npfeng@citiz.net
Zhang
Z X
ZX
An
D K
DK
Han
X W
XW
Huan
W L
WL
Wang
G J
GJ
D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism*; D001711:Biotransformation; D015394:Molecular Structure; D011817:Rabbits
C475967:7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine; D001599:Berberine