Aminoglycoside-induced reversible tubular dysfunction.
Nonoliguric renal insufficiency is a well-known nephrotoxic consequence of aminoglycosides, although reversible tubular damage in the absence of any change in the renal function has been occasionally found. Reported herein are 2 representative cases of a reversible tubular damage due to prolonged aminoglycoside administration: a patient with a Fanconi-like syndrome of proximal tubular dysfunction and a patient with a syndrome of hypokalemic metabolic alkalosis associated with hypomagnesemia.
Alexandridis
George
G
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Liberopoulos
Evagelos
E
Elisaf
Moses
M
D000368:Aged; D000471:Alkalosis / Q000139:chemically induced; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D007687:Kidney Tubules, Proximal / Q000503:physiopathology*; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008275:Magnesium Deficiency / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D011189:Potassium Chloride / Q000627:therapeutic use; D014031:Tobramycin / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D011189:Potassium Chloride; D008274:Magnesium; D014031:Tobramycin