[Application of rCBF imaging in PD, AD and OPCA].
OBJECTIVE
To evaluate the diagnosis and differential diagnosis of rCBF imaging in Parkison's disease (PD), Alzheimer's disease (AD) and olivopontocerebellar atrophy (OPCA).


METHODS
The characteristics of the radioactive distribution of rCBF imaging in PD, AD and OPCA were analyzed, and the laws of the radioactive distribution were identified.


RESULTS
The sensitivity of rCBF imaging in PD, AD and OPCA was 88.4% (38/43), 95.8% (23/24), and 85.7% (30/35) respectively. The characteristics of the radioactive distribution were that the radioactivity decreased in the cerebral cortex (25/43), basal nuclei (21/43) and thalamus (18/43) in PD, that the radioactivity decreased in the bilateral cerebral cortex (17/24) in AD, that the radioactivity decreased in the cerebral cortex (17/35), cerebellum (14/35), basal nuclei (14/35) and thalamus (10/35) in OPCA.


CONCLUSIONS
rCBF imaging could sensitively diagnose PD, AD and OPCA, and also could differentially diagnose them according to their different characteristics of the radioactive distribution.
Deng
Hao-yu
HY
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009849:Olivopontocerebellar Atrophies / Q000000981:diagnostic imaging*; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging