[Transarterial intrahepatic xenotransplantation of microencapsulated newborn porcine islets--an experimental study of type 1 diabetes mellitus].
OBJECTIVE
To evaluate the physiologic features and probable side effects of transarterial intrahepatic xenotransplantation of microencapsulated newborn porcine islets.


METHODS
Six artificial diabetic canines were transplanted intrahepatically with 6-9 x 10(5) encapsulated newborn porcine islets without immunosuppression. Before and after the transplantation, the serum C peptide, glucose tolerance test, and dosage of insulin were measured. Samples of the livers and pancreases were examined pathologically 6 months after the operation.


RESULTS
After the transplantation of microencapsulated porcine islets, the serum C peptides were elevated significantly. The plasma glucose returned to normal gradually. The dosage of insulin decreased. Six months after the operation, the usage of insulin in 2 dogs was stopped and the normal plasma glucose was kept for 180 days. The pathologic examination showed the xenografts located in the interlobular artery of the livers and the livers of canines were not damaged.


CONCLUSIONS
The transplantation may correct the high plasma glucose level of diabetic canines without immunosuppression and has no side reactions.
Ye
Bin
B
Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Wang
Wei
W
Liu
Sheng
S
D000818:Animals; D000831:Animals, Newborn; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D004285:Dogs; D004339:Drug Compounding; D005260:Female; D006499:Hepatic Artery; D016381:Islets of Langerhans Transplantation; D008297:Male; D013552:Swine; D014183:Transplantation, Heterologous