[Morpholgical, histological and histochemical observations on the effect of albendazole on encysted larvae of Trichinella spiralis in mice].
OBJECTIVE
To study the mechanism of action of albendazole on encysted larvae of Trichinella spiralis in mice.


METHODS
Twelve Kunming strain mice each infected with 200 T. spiralis larvae were equally divided into two groups. Six mice of the treatment group were treated with 30 mg of albendazole/kg daily for 5 days. Morphological, histological and histochemical methods were used.


RESULTS
The encysted larvae of albendazole-treated group became significantly damaged, most worms were shrunken and surrounded by inflammatory cells. Histochemical study demonstrated that the glycogen and RNA content of the larvae in the treated group was decreased, the activities of SDH, ATPase, ACP were lower than those of the control group.


CONCLUSIONS
Albendazole can affect the physiological function of Trichinella spiralis.
Chen
X
X
Department of Parasitology, Chengde Medical College, Chengde 067000.
Chen
P
P
Ji
F
F
Wang
Y
Y
Wang
F
F
Wang
F
F
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D007814:Larva / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D017160:Trichinella spiralis / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism
D000871:Anthelmintics; D015766:Albendazole