title: Low level radiation exposure the radiobiologist's challenge in the next millennium.
abstract: A formal definition for low level exposure does not exist. This has arbitrarily been defined here as exposures from 0 to 5 cGy. The health implications of exposures within this dose range are highly controversial since the effects are exclusively stochastic. As such, the effects can only be detected in large populations. The Oxford Survey of Childhood Cancers (OSCC) established leukaemia as a predominant effect. After the chernobyl nuclear disaster, studies in European countries have correlated perinatal mortality with radioactive contaminations which could only have raised the radiation burdens by levels which are currently regarded as negligible. The reported risk indices for childhood leukaemia arising from low level exposures are generally comparable to those ascertained for high exposures, thus posing an enigma to radiobiologists. This paper reviews the progress in various areas of radiobiological research and attempts to make a synthesis of the facts with the view to provide an explanation. The purpose is also to stimulate an understanding of multifactorial biological mechanisms. Environmental radiation exposures must be expected to be concomitant with other toxic agents which must be taken into account in risk assessment. The challenge in the future will be to realise this goal.
authors.affiliation: Institute for Toxicology, Centre for Environmental Sciences, University of Kiel Brunswiker Str. 10, 24105 Kiel, Germany.
authors.forename: Abraham F G
authors.initials: AF
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D002648:Child; D006801:Humans; D011829:Radiation Dosage; D011830:Radiation Effects; D011832:Radiation Injuries / Q000209:etiology*; D011839:Radiation, Ionizing; D018570:Risk Assessment