Oxidant stress in pre-eclampsia and essential hypertension.
BACKGROUND
Endothelial cell dysfunction may play a role in the pathobiology of pre-eclampsia and human essential hypertension. Vasodilators and platelet anti-aggregators such as prostacyclin and nitric oxide are produced by endothelial cells. The half-life of prostacyclin and nitric oxide are reduced by superoxide anion, whereas superoxide dismutase antagonizes its action.


OBJECTIVE
To estimate the plasma concentrations of nitric oxide and lipid peroxides and those of catalase and superoxide dismutase in patients with pre-eclampsia and essential hypertension.


METHODS
Patients of essential hypertension and pre-eclampsia were selected for the study. Nitric oxide and lipid peroxides were estimated in the plasma and anti-oxidants catalase and superoxide dismutase were estimated in the RBC membranes.


RESULTS
The ratio between lipid peroxides and nitric oxide was elevated and the activity of superoxide dismutase reduced in patients with pre-eclampsia and uncontrolled essential hypertension.


CONCLUSIONS
These results suggest that oxidants and anti-oxidants are altered in human essential hypertension and pre-eclampsia.
Kumar
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EFA Sciences LLC, 1420 Providence Highway, Suit # 266, Norwood, MA 02062, USA.
Das
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D000328:Adult; D002374:Catalase / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D014810:Vitamin E; D009569:Nitric Oxide; D002374:Catalase; D013482:Superoxide Dismutase