Regulation of endocytic traffic by Rho GTPases.
The members of the Rho subfamily of small GTPases are key regulators of the actin cytoskeleton. However, recent studies have provided evidence for multiple additional roles for these signalling proteins in controlling endocytic traffic. Here we review our current understanding of Rho GTPase action within the endocytic pathway and examine the potential points of convergence with the more established, actin-based functions of these signalling proteins.
Qualmann
Britta
B
Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D-39008, Magdeburg, Germany.
Mellor
Harry
H
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010587:Phagocytosis; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D020741:rho GTP-Binding Proteins