title: Preparation and in vitro evaluation of modified release ketoprofen microsponges.
abstract: Microsponges containing ketoprofen and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The effects of different mixing speeds, drug-polymer ratios, solvent-polymer ratios on the physical characteristics of the microsponges as well as the in vitro release rate of the drug from the microsponges were investigated. All the factors studied had an influence on the physical characteristics of the microsponges. In vitro dissolution results showed that the release rate of ketoprofen was modified in all formulations.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Tansel
authors.initials: T
authors.lastname: Comoğlu
authors.forename: Nurşin
authors.initials: N
authors.lastname: Gönül
authors.forename: Tamer
authors.initials: T
authors.lastname: Baykara
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007660:Ketoprofen / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008863:Microspheres
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; C050528:Eudragit RS; D007660:Ketoprofen