title: [Study on family aggregation of cases of advanced schistosomiasis japonica].
abstract: OBJECTIVE
  To explore the family aggregation of advanced schistosomiasis japonica.
  
  
  METHODS
  Eighty-one cases of advanced schistosomiasis(AS) and 67 cases of non-advanced schistosomiasis with history of infections in Yushan County, Jiangxi Province were chosen as proband groups and control groups respectively, then grades 1 and 2 relatives of them were investigated on AS. Family aggregation of AS was analyzed through comparing the prevalence rate between the close and distant relatives of probands and controls and fitting the observed distribution of AS cases among the population by zero-truncated Poisson distribution and zero-truncated negative binomial distribution.
  
  
  RESULTS
  The prevalence rate was higher in the close relatives (Group I relatives) of the probands than in the distant relatives(Group II relatives) of the probands and in the controls' relatives. The observed distribution of AS was beyond the probability of the zero-truncated Poisson distribution, but consistent with the zero-truncated negative binomial distribution.
  
  
  CONCLUSIONS
  Family aggregation of advanced schistosomiasis does exist.
authors.affiliation: Department of Epidemiology, Shanghai Medical University, Shanghai 200032.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.forename: D
authors.initials: D
authors.lastname: Lin
authors.forename: F
authors.initials: F
authors.lastname: Hu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016010:Binomial Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012554:Schistosomiasis japonica / Q000453:epidemiology* / Q000235:genetics