[Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].
OBJECTIVE
To study on the detoxification effect of sinamine in morphine-dependent rats.


METHODS
Morphine-dependent rats were induced by injecting morphine on dosage increasing by degrees, then treated with medication. The withdrawal symptoms, body weight and NE, DA, 5-HT in the brain were tested.


RESULTS
Sinamine could alleviate withdrawal symptom, reablement body weight, inhibit neurotransmitter in the brain.


CONCLUSIONS
Sinamine have effects on morphine-dependent rats which may relate to modulating neurotransmitter.
Wang
Caiyun
C
First Military Medical University, Guangzhou 510515.
Mo
Zhixian
Z
Zhu
Qiushuang
Q
Wen
Lei
L
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009021:Morphine Dependence / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D015306:Biogenic Monoamines; D009019:Morphinans; D012701:Serotonin; C009271:sinomenine; D004298:Dopamine; D009638:Norepinephrine