[Associations between six functional genes and schizophrenia].
OBJECTIVE
To assess the associations between schizophrenia and six functional genes: dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), 5-hydroxytryptamine 2A receptor gene (5-HT2A), 5-HT6 receptor gene (5-HT6), catechol-O-methyltransferase gene (COMT) and dopamine transporter gene (DAT1).


METHODS
With the techniques of Amp-RFLP and Amp-FLP, association analysis was made between schizophrenia and the six genes in 67 schizophrenic patients from Chinese Han population.


RESULTS
(1) Neither genotypes nor alleles of DRD2, 5-HT2A, 5-HT6 and COMT gene showed significant differences between patients and controls (P>0.05). (2) Six repeats (6R) in DRD4 gene, the allele of 480 bp and the genotype of 480/520 in DAT1 gene were found to be of significant differences between the two groups (P<0.05). (3) Only one negative association was observed between the 480 bp allele of DAT1 gene and schizophrenia (OR=0.441, 95% CI:0.202-0.963, Z=2.05, P<0.05).


CONCLUSIONS
The 480 bp allele of DAT1 gene is negatively associated with schizophrenia in Chinese Han population, which stands for the dopamine hypothesis of schizophrenia.
Zhang
Ming-lian
ML
The Seventh People Hospital of Wuxi City, Wuxi, Jiangsu, PR China. Yjj-wx@sina.com
Yuan
Guo-zhen
GZ
Yao
Jian-jun
JJ
Qian
Yong-chao
YC
Zhang
Xia
X
Huang
Yin-ping
YP
Tang
Rui-chun
RC
Ji
Qing
Q
Jiang
San-duo
SD
D000328:Adult; D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics; D004247:DNA / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D012150:Polymorphism, Restriction Fragment Length; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
C493599:DRD4 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; C493214:SLC6A3 protein, human; C097216:serotonin 6 receptor; D050638:Receptors, Dopamine D4; D004247:DNA; D002394:Catechol O-Methyltransferase