Recurrent isosporiasis over a decade in an immunocompetent host successfully treated with pyrimethamine.
Recurrent isosporiasis in an immunocompetent host is reported. The patient suffered from chronic intermittent diarrhea for over a decade. Multiple short-term administrations of trimethoprim-sulfamethoxazole followed by pyrimethamine, or albendazole combined with tinidazole could not control the relapses. However, treatment with pyrimethamine, 25 mg/d for 20 weeks, was successful.
Jongwutiwes
Somchai
S
Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. fmedsjw@md2.md.chula.ac.th
Sampatanukul
Pichet
P
Putaporntip
Chaturong
C
D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006801:Humans; D007121:Immunocompetence; D007549:Isospora / Q000302:isolation & purification; D021865:Isosporiasis / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011739:Pyrimethamine / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors; D014011:Tinidazole / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D014011:Tinidazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015766:Albendazole; D011739:Pyrimethamine