Abuse of clenbuterol and its detection.
Clenbuterol and other beta-agonists are commonly misused as repartitioning agents in meat production and as doping substances to improve athletic performance. Numerous reports on food poisoning throughout Europe prompted the EU regulatory offices and FDA to implement a ban on the use of beta-agonists as growth promoters. Several analytical methods have been developed for detecting illegal administration of these compounds, based mainly on chromatography and immunoassay screening. This article deals with the pharmacological aspect of beta-agonists in growth promotion, control of their abuse and methods of analysis.
Prezelj
Andrej
A
Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia. andrej.prezelj@ffa.uni-lj-si
Obreza
Ales
A
Pecar
Slavko
S
D000318:Adrenergic beta-Agonists / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D002976:Clenbuterol / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism* / Q000517:prevention & control
D000318:Adrenergic beta-Agonists; D002976:Clenbuterol