title: Effects of aerosolized dust in goats on lung clearance of Pasteurella and Mannheimia species.
abstract: The objective was to determine whether the inhalation of large quantities of feedyard dust predisposed the animals to pulmonary bacterial proliferation. Two control groups, C1 and C2, did not receive dust treatments, and two principal groups (P1 and P2) received a total of 14 dust treatments each. The C1 and P1 groups of goats each received a transthoracic challenge of live Mannheimia haemolytica (4 x 10(6) colony forming units, CFU) The C2 and P2 groups of goats each received a transthoracic challenge of live Pasteurella multocida (1.0 x 10(6) CFU/goat). The results showed that dusted animals had fever when compared with non-dusted controls. In addition, dusted animals demonstrated a leukocytosis with neutrophilia after the first dust treatment that was not sustainable. Finally, dusted animals demonstrated pulmonary clearance of two potential bacterial pathogens that was not significantly different from that shown by control (not dusted) animals.
authors.affiliation: USDA, Agricultural Research Service, Conservation and Production Research Laboratory, Bushland, TX 79012, USA. cwpurdy@cprl.ars.usda.gov
authors.forename: Charles W
authors.initials: CW
authors.lastname: Purdy
authors.forename: David C
authors.initials: DC
authors.lastname: Straus
authors.forename: Norbert
authors.initials: N
authors.lastname: Chirase
authors.forename: Jon R
authors.initials: JR
authors.lastname: Ayers
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hoover
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage; D000818:Animals; D004391:Dust; D005260:Female; D015511:Goat Diseases / Q000209:etiology / Q000382:microbiology*; D006041:Goats; D007958:Leukocyte Count; D008168:Lung / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D031121:Mannheimia / Q000302:isolation & purification; D010325:Pasteurella / Q000302:isolation & purification; D010326:Pasteurella Infections / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D015661:Pasteurellaceae / Q000302:isolation & purification*; D016871:Pasteurellaceae Infections / Q000209:etiology / Q000382:microbiology / Q000662:veterinary; D018410:Pneumonia, Bacterial / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D013696:Temperature
chemical_list: D000336:Aerosols; D004391:Dust