Paroxysmal nocturnal hemoglobinuria arising from Fanconi anemia.
The progress of a female child with African type Fanconi anemia that evolves in time into paroxysmal nocturnal hemoglobinuria is described. Modern diagnostic methods are used to confirm this process. A discussion of possible mechanisms ensues.
Wainwright
Linda
L
University of the Witwatersrand, Chris-Hani-Baragwanath Hospital, Johannesburg, South Africa. sjaspan@iafrica.com
Brodsky
Robert A
RA
Erasmus
Linda K
LK
Poyiadjis
Stelios
S
Naidu
Gita
G
MacKinnon
Diane
D
D002648:Child; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications*; D005260:Female; D005434:Flow Cytometry; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000209:etiology*; D006801:Humans