title: Anti-Ce complicating two consecutive pregnancies with increasing severity of haemolytic disease of the newborn.
abstract: The Ce antigen is expressed on red cells of individuals with Rh haplotypes, R1 or CDe and r' or Cde. However, anti-Ce is rare, and only two cases of severe haemolytic disease of the newborn (HDN) caused by this antibody have been described (Malde et al., 2000; Wagner et al., 2000). We describe a woman who was found to have anti-Ce in her second pregnancy, resulting in a neonate with HDN that required exchange transfusion. She subsequently had a twin pregnancy, where both the twins were affected by severe haemolytic disease (HD) of the fetus because of anti-Ce and required repeated fetal transfusions, followed by exchange transfusions after birth. This is the first reported case of HD caused by anti-Ce requiring fetal transfusions.
authors.affiliation: Red Cell Immunohaematology Antenatal Service, National Blood Service, Cambridge, UK. edmund.ranasinghe@nbs.nhs.uk
authors.forename: E
authors.initials: E
authors.lastname: Ranasinghe
authors.forename: E
authors.initials: E
authors.lastname: Goodyear
authors.forename: G
authors.initials: G
authors.lastname: Burgess
mesh_terms: D000328:Adult; D001803:Blood Transfusion; D004200:Diseases in Twins; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
chemical_list: D006023:Glycoproteins; C066468:RHCE protein, human; D012204:Rh-Hr Blood-Group System