Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress. a randomized controlled trial.
OBJECTIVE
We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress.


METHODS
This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid.


RESULTS
During supplementation, plasma vitamin C and alpha-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable.


CONCLUSIONS
In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins.
Aghdassi
Elaheh
E
Gastroenterology and Nutrition Research, Department of Medicine, Toronto General Hospital, University Health Network, Ontario, Canada.
Wendland
Barbara E
BE
Steinhart
A Hillary
AH
Wolman
Stephen L
SL
Jeejeebhoy
Khursheed
K
Allard
Johane P
JP
D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D015227:Lipid Peroxidation; D009961:Orosomucoid / Q000032:analysis; D018384:Oxidative Stress; D014810:Vitamin E / Q000627:therapeutic use*
D009961:Orosomucoid; D014810:Vitamin E; D001205:Ascorbic Acid