[Studies on the hydroxyl free radical-scavenging effect of combined selenium and germanium].
The effect of selenium, carboxyethyl-germanium sesquioxide (Ge-132) and the combination of selenium and Ge-132 on the production of hydroxyl free radical in liver microsomes of rats treated with Fe2SO4-NADPH system was studied with electron spin resonance technique (ESR). The results showed that the production of hydroxyl free radical was decreased significantly by adding selenium, Ge-132 and combined selenium and Ge-132, indicating a direct scavenging effect on hydroxyl free radical. It was also observed a enhanced scavenging effect at the low concentration of combined selenium and Ge-132.
Wu
Z
Z
Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen
X
X
Yang
K
K
Xia
T
T
D000818:Animals; D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005857:Germanium / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*
D016166:Free Radical Scavengers; D005857:Germanium; D017665:Hydroxyl Radical; D012643:Selenium