title: [Studies on the hydroxyl free radical-scavenging effect of combined selenium and germanium].
abstract: The effect of selenium, carboxyethyl-germanium sesquioxide (Ge-132) and the combination of selenium and Ge-132 on the production of hydroxyl free radical in liver microsomes of rats treated with Fe2SO4-NADPH system was studied with electron spin resonance technique (ESR). The results showed that the production of hydroxyl free radical was decreased significantly by adding selenium, Ge-132 and combined selenium and Ge-132, indicating a direct scavenging effect on hydroxyl free radical. It was also observed a enhanced scavenging effect at the low concentration of combined selenium and Ge-132.
authors.affiliation: Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Yang
authors.forename: T
authors.initials: T
authors.lastname: Xia
mesh_terms: D000818:Animals; D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005857:Germanium / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*
chemical_list: D016166:Free Radical Scavengers; D005857:Germanium; D017665:Hydroxyl Radical; D012643:Selenium