title: Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using chiral spiro phosphoramidites as ligands.
abstract: Novel monodentate chiral spiro phosphoramidite ligands have been readily synthesized in good yields from enantiomerically pure 1,1'-spirobiindane-7,7'-diol. The new ligands were highly efficient in the copper-catalyzed conjugate addition of Et(2)Zn to enones with up to 98% enantiomeric excess.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, PR China.
authors.forename: Hai
authors.initials: H
authors.lastname: Zhou
authors.forename: Wen-Hu
authors.initials: WH
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Shi
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou