Telomeres and cancer: a tale with many endings.
Telomerase activity is necessary to maintain the integrity of telomeres, which in turn prevent chromosome ends from being processed and signaled as damaged DNA. That cancer cells rely on telomerase to maintain functional telomeres and to divide indefinitely has highlighted the potential for developing novel therapeutic approaches that target telomerase.
Blasco
María A
MA
Department of Immunology and Oncology, National Centre of Biotechnology, Madrid, Spain. mblasco@cnb.uam.es
D000818:Animals; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
D019098:Telomerase