Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar patients.
BACKGROUND
Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients.


METHODS
IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate.


RESULTS
The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls.


CONCLUSIONS
A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.
Shaltiel
G
G
Stanley Research Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel.
Shamir
A
A
Nemanov
L
L
Yaroslavsky
Y
Y
Nemets
B
B
Ebstein
R P
RP
Belmaker
R H
RH
Agam
G
G
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000201:enzymology* / Q000473:pathology*; D001921:Brain / Q000201:enzymology* / Q000473:pathology*; D018929:Cell Culture Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000201:enzymology / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000201:enzymology / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D013053:Spectrophotometry
D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase