title: Correlation between accelerated presbycusis and decreased immune functions.
abstract: The aim of the current study is to analyze the relationship between presbycusis and the immune system, which is affected by pathogenic environments, and to devise a strategy for the prevention of presbycusis using the SAMP1 mouse, an animal model for accelerated senescence that shows both immunological dysfunction and hearing loss caused by the impairment of spiral ganglion cells in the cochlea. When these mice were bred in different pathogenic environments, we found that the development of age-related diseases such as presbycusis was delayed in the mice bred under clean conditions. Prednisolone administration showed no significant prevention of the development of presbycusis in the mice, suggesting that autoimmune mechanisms are not involved in the acceleration of presbycusis. It is conceivable that pathogen-induced infections impose a severe stress on the host, impairing the host's immune functions. A reduction in the number of pathogens may therefore prevent the acceleration of the aging process. These findings suggest that not only the gene backgrounds but also immune functions affect the development of presbycusis in SAMP1 mice. Further studies into the relationship between systemic immune functions and the neuro-generation system may provide additional information about the treatment for age-related diseases.
authors.affiliation: Department of Otorhinolaryngology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwai
authors.forename: Shinryu
authors.initials: S
authors.lastname: Lee
authors.forename: Muneo
authors.initials: M
authors.lastname: Inaba
authors.forename: Kikuya
authors.initials: K
authors.lastname: Sugiura
authors.forename: Susumu
authors.initials: S
authors.lastname: Baba
authors.forename: Koichi
authors.initials: K
authors.lastname: Tomoda
authors.forename: Toshio
authors.initials: T
authors.lastname: Yamashita
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000276:immunology; D005938:Glucocorticoids / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011239:Prednisolone / Q000494:pharmacology; D011304:Presbycusis / Q000276:immunology*; D011897:Random Allocation
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone