Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression.
OBJECTIVE
Neuroimaging studies reveal abnormalities of regional cerebral blood flow (rCBF) in major depression. In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant.


METHODS
A trial of venlafaxine was performed with seven patients referred with ICD-10 major depression. At entry and 6-week follow-up, the Beck Depression Inventory and Hamilton Depression Rating Scale were administered and rCBF was measured by means of single photon emission computed tomography with [(99m)Tc]hexamethylpropyleneamine oxime. Blood flow changes were explored with statistical parametric mapping.


RESULTS
The subjects showed significant improvement after treatment. Statistical parametric mapping analysis revealed increased rCBF bilaterally in the thalamus and decreased rCBF in the left occipital lobe, right cerebellum, and temporal cortex bilaterally.


CONCLUSIONS
These data confirm limbic cortical rCBF changes associated with effective antidepressant treatment.
Davies
Julia
J
Mental Health Research Group, Peninsula Medical School, Plymouth, UK.
Lloyd
Keith R
KR
Jones
Ivor K
IK
Barnes
Anna
A
Pilowsky
Lyn S
LS
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D003511:Cyclohexanols / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008032:Limbic System / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012039:Regional Blood Flow / Q000187:drug effects; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D019690:Technetium Tc 99m Exametazime; D000069470:Venlafaxine Hydrochloride