Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis.
A 65-year-old woman presented with an 8-year history of progressive frontotemporal alopecia and hirsutism. She had elevated serum levels of testosterone, androstenedione and estradiol. Ultrasound and computed tomography imaging suggested a right ovarian mass, while bilateral ovarian venous sampling demonstrated increased testosterone levels originating from both ovarian veins. Histology obtained following bilateral oophorectomy demonstrated bilateral ovarian hyperthecosis. Six months after surgery, the patient remains well with no progression of the alopecia. Ovarian hyperthecosis is a rare cause of androgenetic alopecia in postmenopausal women. The role of hyperthecosis and its relationship to androgenetic alopecia is reviewed.
Kim
Youngjin
Y
Clinical School and Department of Anatomical Pathology, University of New South Wales, New South Wales, Australia.
Marjoniemi
Veli-Matti
VM
Diamond
Terry
T
Lim
Adrian
A
Davis
Greg
G
Murrell
Dedee
D
D000368:Aged; D000505:Alopecia / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism / Q000209:etiology* / Q000473:pathology; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D017698:Postmenopause; D011859:Radiography; D013798:Thecoma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D014463:Ultrasonography