Effect of feeding Murraya koeingii and Brassica juncea diet on [correction] kidney functions and glucose levels in streptozotocin diabetic mice.
Purpose of the study was to investigate the effects of daily oral feeding 15% of powdered leaves of Murraya koeingii (MK) (commonly called as Curry patta) and 10% powder of seeds of Brassica juncea (BJ) (commonly called as Rai) for 60 days on serum glucose concentrations and kidney functions in streptozotocin (STZ; 100mg/kg) diabetic rats. Serum glucose levels, body weight, urine volume, serum creatinine, and urinary albumin (UAE) levels were monitored on day 0, 10, 25, 40, and 70 of the experiment. After 60 days of STZ administration, urine volume per day and UAE levels were significantly higher (P<0.0005) in diabetic controls (DC) as compared to normal controls (NC). Although feeding of the MK/BJ showed a trend towards improvement in most of the parameters, results were not statistically different from the DC except in serum creatinine values in BJ-fed rats on day 70. Thus, these plants can be best utilized by promoting them as preferable food adjuvants for diabetic patients.
Grover
J K
JK
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110049, India. jkgrover@hotmail.com
Yadav
S P
SP
Vats
V
V
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology*; D004032:Diet; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D032101:Murraya; D009149:Mustard Plant; D009929:Organ Size / Q000187:drug effects; D018515:Plant Leaves; D012639:Seeds; D012709:Serum Albumin / Q000378:metabolism; D013311:Streptozocin
D001786:Blood Glucose; D012709:Serum Albumin; D013311:Streptozocin; D003404:Creatinine