title: [Study on animal models for hyperlipidemia].
abstract: To establish a better animal model for hyperlipidemia, three animal models with SD rats, Wistar rats and golden hamsters were explored. The semi-purified diet for rats was composed of 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. The semi-purified diet for hamster was composed of 0.2% cholesterol, 15% lard and 85% normal diet. Serum TC, TG, HDL-C, liver cholesterol and triglyceride were assayed. Serum TG of SD rat, Wistar rat and hamster was 194.4%, 86.2% and 84.3% respectively higher than that of control after 5 weeks of experiment. Serum TC of the three groups was 76.8%, 48.3% and 134.8% respectively higher than that of control. The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be better for hypertriglyceridemia.
authors.affiliation: Department of Nutrition and Food Hygiene, Beijing University, Beijing 100083, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Keji
authors.initials: K
authors.lastname: Li
authors.forename: Shiying
authors.initials: S
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D006949:Hyperlipidemias; D008297:Male; D008647:Mesocricetus; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013045:Species Specificity