[Study on lipid peroxidation of electrolyzing-aluminum workers].
In order to study the changes in lipid peroxidation level and anti-oxidase activity in electrolyzing-aluminum workers exposed to both aluminum and fluoride and to find out the sensitive biological monitoring indicators, 65 electrolyzing-aluminum workers are recruited as exposed group and 52 healthy workers as control group. Serum and urine aluminum and fluoride concentration, serum glutathione peroxidase(GSH-Px) activity, serum malonyl dialdehyde (MDA) concentration, whole blood superoxide dismutase(SOD) activity, serum cuprum and zinc concentration, and X-ray of skeleton are detected and taken. The results showed that aluminum and fluoride concentration in serum and urine increase, GSH-Px activity reduces, MDA concentration increases and SOD activity increases, cuprum concentration increases and zinc concentration reduces significantly (P < 0.001) in exposed group compared with those of control group. Both serum aluminum and fluoride concentration are correlated inversely with GSH-Px activity, and correlated with MDA concentration and SOD activity. It is suggested that serum aluminum and fluoride concentration can clearly reflect the loading capacity of body aluminum and fluoride. Occupational exposure to both aluminum and fluoride lead to rising of lipid peroxidation and abnormal metabolism of cuprum and zinc before changes in skeleton occurred. Serum MDA concentration and GSH-Px activity might be the potential early-stage indicators of biological surveillance for electrolyzing-aluminum workers' health. The increase of SOD activity may be a kind of body compensations.
Guo
Zhiyong
Z
School of Public Health, Anhui Medical University, Hefei 230032, China.
Zhu
Qixing
Q
Hu
Chuanlai
C
Yang
Yongjian
Y
D000535:Aluminum / Q000009:adverse effects*; D004572:Electrolysis; D005459:Fluorides / Q000009:adverse effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D017616:Magnesium Compounds / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*
D017616:Magnesium Compounds; C031288:magnesium fluoride; D000535:Aluminum; D005459:Fluorides