[Human Mismatch Repair System in Hematologic Malignancies]
The human mismatch repair (hMMR) system consists of members of three super-families, namely MutH, MutL and MutS. They are able to correct the error of nucleotide incorporation, increase the fidelity of DNA replication, reduce spontaneous mutation, and maintain the stability of microsatellite loci and genome. The dysfunction of MMR may induce to carcinogenesis. The relation of MMR and hematologic malignancies is presented in the article.
Wu
Yu-Dan
YD
Institute of Hematology, Union Hospital, Tongji Medical University, Wuhan 430022, China.