title: Carcinogenicity of methyl-tertiary butyl ether in gasoline.
abstract: Methyl tertiary butyl ether (MTBE) was added to gasoline on a nationwide scale in 1992 without prior testing of adverse, toxic, or carcinogenic effects. Since that time, numerous reports have appeared describing adverse health effects of individuals exposed to MTBE, both from inhalation of fumes in the workplace and while pumping gasoline. Leakage of MTBE, a highly water-soluble compound, from underground storage tanks has led to contamination of the water supply in many areas of the United States. Legislation has been passed by many states to prohibit the addition of MTBE to gasoline. The addition of MTBE to gasoline has not accomplished its stated goal of decreasing air pollution, and it has posed serious health risks to a large portion of the population, particularly the elderly and those with respiratory problems, asthma, and skin sensitivity. Reports of animal studies of carcinogenicity of MTBE began to appear in the 1990s, prior to the widespread introduction of MTBE into gasoline. These reports were largely ignored. In ensuing years, further studies have shown that MTBE causes various types of malignant tumors in mice and rats. The National Toxicology Program (NTP) Board of Scientific Counselors' Report on Carcinogens Subcommittee met in December 1998 to consider listing MTBE as "reasonably anticipated to be a human carcinogen." In spite of recommendations from Dr. Bailer, the primary reviewer, and other scientists on the committee, the motion to list MTBE in the report was defeated by a six to five vote, with one abstention. On the basis of animal studies, it is widely accepted that if a chemical is carcinogenic in appropriate laboratory animal test systems, it must be treated as though it were carcinogenic in humans. In the face of compelling evidence, NTP Committee members who voted not to list MTBE as "reasonably anticipated to be a human carcinogen" did a disservice to the general public; this action may cause needless exposure of many to health risks and possibly cancers.
authors.affiliation: Department of Environmental Medicine, The Mount Sinai Medical Center, New York, New York 10029, USA. mehlman@rcn.com
authors.forename: Myron A
authors.initials: MA
authors.lastname: Mehlman
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution / Q000517:prevention & control; D000818:Animals; D001681:Biological Assay; D002104:Cadmium / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity*; D004357:Drug Synergism; D004781:Environmental Exposure / Q000517:prevention & control; D005260:Female; D005742:Gasoline / Q000633:toxicity*; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000302:isolation & purification / Q000633:toxicity*; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000145:classification; D051381:Rats; D011916:Rats, Inbred F344; D012907:Smoking / Q000009:adverse effects; D014481:United States / Q000453:epidemiology
chemical_list: D000393:Air Pollutants; D002273:Carcinogens; D005742:Gasoline; D008738:Methyl Ethers; D002104:Cadmium; C043243:methyl tert-butyl ether