title: Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats.
abstract: Tert-amyl-methyl ether (TAME) was administered by gavage in extra virgin olive oil solution at concentrations of 750, 250, or 0 mg/kg bw to groups of 100 male and 100 female Sprague-Dawley rats 8 weeks old at the start of the experiment. Di-isopropyl ether (DIPE) was administered in the same manner at the doses of 1000, 250, or 0 mg/kg body weight to groups of 100 male and 100 female Sprague-Dawley rats. TAME and DIPE were each delivered in 1-mL solution 4 days a week for 78 weeks. Control animals received 1 mL of extra virgin olive oil without TAME or DIPE. At the end of the treatment period, all animals were kept under observation until spontaneous death. Under these test conditions, TAME and DIPE were found to be potential carcinogenic agents for various organs and tissues.
authors.affiliation: Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Belpoggi
authors.forename: Morando
authors.initials: M
authors.lastname: Soffritti
authors.forename: Franco
authors.initials: F
authors.lastname: Minardi
authors.forename: Luciano
authors.initials: L
authors.lastname: Bua
authors.forename: Elisa
authors.initials: E
authors.lastname: Cattin
authors.forename: Cesare
authors.initials: C
authors.lastname: Maltoni
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001681:Biological Assay / Q000379:methods; D002273:Carcinogens / Q000633:toxicity*; D004987:Ethers / Q000633:toxicity*; D005260:Female; D008297:Male; D008738:Methyl Ethers / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000145:classification / Q000473:pathology; D051381:Rats
chemical_list: D000393:Air Pollutants; D002273:Carcinogens; D004987:Ethers; D008738:Methyl Ethers; C096680:tertiary-amyl methyl ether; C011779:diisopropyl ether