Antiphospholipid antibodies and stroke in Down syndrome.
Two patients with Down syndrome and the primary antiphospholipid antibody are described. One patient had a vasculopathy similar to that previously described as Moyamoya. Down syndrome is characterized by immune defects including a tendency to autoimmune phenomena. This report extends the scope of these observations and particularly draws out the potential role of antiphospholipid antibodies. Indeed antiphospholipid antibodies may well explain the well-known association of Down syndrome and stroke.
Gatenby
P
P
Department of Immunopathology, The Canberra Hospital and the Canberra Clinical School, University of Sydney, Garran, ACT, Australia. paul.gatenby@act.gov.au
Tucko
R
R
Andrews
C
C
O'Neil
R
R
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D004314:Down Syndrome / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D020521:Stroke / Q000150:complications* / Q000276:immunology*
D017152:Antibodies, Antiphospholipid