Effect of some psychotropic drugs on luminol-dependent chemiluminescence induced by O2-, *OH, HOCl.
We studied antioxidant activity of six neuroleptics (chlorpromazine, levomepromazine, promethazine, trifluoperazine and thioridazine) and two antidepressants (imipramine and amitriptyline) in the range of concentration of 10(-7)-10(-4) M. We applied luminol-dependent chemiluminescence to test the ability of these drugs to scavenge the biologically relevant oxygen-derived species: hydroxyl radical, superoxide radical, hypochlorous acid in vitro. We found that the phenothiazines were powerful scavengers of hydroxyl and superoxide radicals. Chlorprothixene, amitriptyline and imipramine had no scavenge activity to the superoxide radical. All drugs showed a moderate scavenger effect on hypochloric anion.
Hadjimitova
Vera
V
Department of Medical Physics and Biophysics, Sofia University School of Medicine, Sofia 1431, Bulgaria. vera@medfac.acad.bg
Traykov
Trayko
T
Mileva
Milka
M
Ribarov
Stefan
S
D000928:Antidepressive Agents / Q000032:analysis; D014150:Antipsychotic Agents / Q000032:analysis*; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D008163:Luminescent Measurements; D008165:Luminol; D010640:Phenothiazines; D012680:Sensitivity and Specificity; D013481:Superoxides; D019820:Xanthine; D014969:Xanthine Oxidase
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D010640:Phenothiazines; D013481:Superoxides; D019820:Xanthine; D017665:Hydroxyl Radical; D008165:Luminol; D006997:Hypochlorous Acid; D014969:Xanthine Oxidase