An efficient method for removal of ruthenium byproducts from olefin metathesis reactions.
[reaction: see text] Sequential treatment of the ring-closing metathesis reaction products with silica gel, activated carbon (50 equiv wt relative to the crude products), and column chromatography on silica gel efficiently removed dark brown ruthenium byproducts from the reaction mixture. After this treatment, colorless compounds could be obtained with a ruthenium level of 0.06-0.53 microg per 5 mg of product.
Cho
Jong Hyun
JH
School of Chemistry and Center for Molecular Catalysis, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea.
Kim
B Moon
BM