[Morphofunctional aspects of cardioprotective effect of propranolol in modelling of chronic ischemic heart disease].
In experiments involving simulation of ischemic heart disease in adult rabbits, morphofunctional aspects were studied of cardioprotective action of propranolol on the contractile myocardium. With the aid of histological and histochemical, electron microscopic tests, the drug under consideration has been shown to be endowed with membrane-stabilizing properties, quite aside its receptor-mediated effects on Ca2+ metabolism known for. A decrease in its excessive ingress into the sarcoplasma comes, in its turn, to improve energy and plastic maintenance of the myocardial functions, to moderate a pathological reorganization and destructive changes in cardiomyocytes, thus promoting the contractile myocardium resistance to recurrent coronary crises.
Gavrish
A S
AS
Verbitskiĭ
V V
VV
Shchul'ts
N V
NV
Danilishina
M V
MV
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004195:Disease Models, Animal; D008854:Microscopy, Electron; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D002118:Calcium