title: [Detection of telomerase activity in gastric cancer and adjacent tissues].
abstract: OBJECTIVE
  To study the telomerase activity in chinese gastric cancer and their adjacent tissues and to explore the possibility of telomerase as a tumor biological marker.
  
  
  METHODS
  Telomerase activity was analyzed in 42 primary gastric cancers and their adjacent tissues and 1 benign gastric lesion by a PCR-based telomerase repeat amplification protocol assay.
  
  
  RESULTS
  The result showed 88.1% (37/42) gastric cancerous specimens displayed telomerase activity. However, only 2 of 42 tissue samples adjacent to the gastric cancer showed telomerase activity. However our results indicated that 1 benign gastric lesion sample expressed telomerase activity.
  
  
  CONCLUSIONS
  The results indicated that the detection of telomerase activity might be a useful method in the diagnosis of gastric cancer.
authors.affiliation: Department of Abdominal Surgery and Centre of Tumor Biology, Cancer Hospital, CAMS and PUMC, Beijing 100021.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Jing
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Zhang
mesh_terms: D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis / Q000201:enzymology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D019098:Telomerase / Q000378:metabolism*
chemical_list: D019098:Telomerase