title: [Molecular mechanisms of environmental estrogens on reproductive and developmental toxicity].
abstract: It has been shown that numerous natural and synthetic chemicals with estrogenic activities are reproductive or developmental toxic factors in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity, however, are very complicated, especially the molecular mechanisms. This article introduced the current progress on molecular mechanisms of toxicity, which included modulating signaling pathways, interfering gene expression during embryo stage, inducing mutation, etc.
authors.affiliation: School of Public Health, Peking University, Beijing 100083, China.
authors.forename: Dingxin
authors.initials: D
authors.lastname: Long
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000235:genetics; D004968:Estrogens, Non-Steroidal / Q000506:poisoning*; D005260:Female; D006801:Humans; D007529:Isoflavones; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D010636:Phenols / Q000506:poisoning*; D048789:Phytoestrogens; D028321:Plant Preparations; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D010636:Phenols; D048789:Phytoestrogens; D028321:Plant Preparations; C006780:bisphenol A; D000098826:Bisphenol A Compounds