Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice.
The gastroprotective effects of 70% acetone extracts of Quercus suber and Quercus coccifera leaves and of tannins (pedunculagin, castalagin, phillyraeoidin A, and acutissimin B) purified from these extracts were examined in the mouse using the ethanol-induced gastric ulcer model. Both extracts (25, 50, and 100 mg/kg), given orally, prevented the formation of ethanol-induced lesions in the stomach. The percent protection varied between 68 and 91%. Purified tannins (50 mg/kg) were also effective in protecting the stomach against ethanol, and the percent protection varied from 66 to 83%. Castalagin was the most potent. Both extracts and all of the tannins tested (10, 25, and 50 microg/mL) strongly inhibited (55-65%) the lipid peroxidation of rabbit brain homogenate. These results suggest that the gastroprotective effects of extracts of Q. suber and Q. coccifera leaves and the purified tannins in this experimental model are related to their anti-lipoperoxidant properties.
Khennouf
Seddik
S
Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology, Faculty of Science, University Ferhat Abbas, 19000 Setif, Algeria. Khennouf_sed@yahoo.fr
Benabdallah
Hassiba
H
Gharzouli
Kamel
K
Amira
Smain
S
Ito
Hideyuki
H
Kim
Tae-Hoon
TH
Yoshida
Takashi
T
Gharzouli
Akila
A
D000096:Acetone; D000818:Animals; D001713:Biphenyl Compounds; D002396:Catechols / Q000627:therapeutic use; D000431:Ethanol; D047348:Hydrolyzable Tannins; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D029963:Quercus / Q000737:chemistry*; D011817:Rabbits; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013634:Tannins / Q000494:pharmacology / Q000627:therapeutic use*
D001713:Biphenyl Compounds; D002396:Catechols; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D013634:Tannins; D000096:Acetone; C084709:vescalagin; D000431:Ethanol