[State of lipid peroxidation, blood antioxidant defense in patients with myocardial infarction aggravated by circulatory insufficiency].
OBJECTIVE
To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure.


METHODS
Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25); 2) those with uncomplicated MI (n = 22). A control group included 17 apparently healthy males. The activity of lipid peroxidation (LPO) and blood antioxidative defense was determined in the patients' red blood cells prewashed off the plasma with saline solution at a temperature of 4 degrees C.


RESULTS
The tension of free radical lipid oxidation mechanisms in patients with MI aggravated by circulatory insufficiency is followed by an increased antiradical activity. In patients with uncomplicated higher LPO activity is attended the less marked activation of antioxidative enzymes. The examinees were found to show a correlation of the global systolic function of the left ventricle with the concentration of LPO products and with the activity of antioxidative enzymes.


CONCLUSIONS
More significant LP activation coupled with left ventricular systolic dysfunction was noted in patients with MI aggravated by acute heart failure.
Tarasov
N I
NI
Tepliakov
A T
AT
Malakhovich
E V
EV
Stepacheva
T A
TA
Fedosova
N N
NN
Kaliuzhin
V V
VV
Pushnikova
E Iu
EIu
D000975:Antioxidants; D005609:Free Radicals; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D013318:Stroke Volume; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals