[Effect of zhuhuang frost on wound hydroxy-proline level after anal operation].
OBJECTIVE
To observe the effect of Zhuhuang Frost (ZHF), an external preparation of Chinese herbal medicine, on level of hydroxy-proline (Hyp) in surgical wound after anal operation.


METHODS
Fifty postoperational patients after low position simple operation of anal fistula were randomly divided into two groups and treated with ZHF and Mayinglong Musk hemorrhoidal paste (MMHP) respectively. The level of Hyp in granulation of wound was tested using alkaline hydrolysis assay at the 3rd, 7th and 14th day after operation respectively.


RESULTS
The Hyp level tested at the 7th and 14th day after operation in the ZHF treated group was higher than that in the MMHP treated group, but those tested at the 3rd postoperational day in the two groups was not different significantly.


CONCLUSIONS
ZHF could increase the Hyp level in postoperational granulation of wound after anal operation.
Zheng
X P
XP
Nanjing Municipal Hospital of TCM, Nanjing 210001.
Ding
Y
Y
Zheng
M Z
MZ
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000378:metabolism* / Q000601:surgery; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage; D008875:Middle Aged; D012003:Rectal Fistula / Q000378:metabolism / Q000601:surgery*; D014945:Wound Healing
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D006909:Hydroxyproline