Effects of natural polysaccharide addition on drug release from calcium-induced alginate gel beads.
Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca.
Murata
Yoshifumi
Y
Faculty of Pharmaceutical Science, Hokuriku University, Japan.
Tsumoto
Kumiko
K
Kofuji
Kyoko
K
Kawashima
Susumu
S
D000464:Alginates / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D002118:Calcium / Q000737:chemistry / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D005782:Gels; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D011134:Polysaccharides / Q000138:chemical synthesis / Q000493:pharmacokinetics*
D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D011134:Polysaccharides; D020723:Glucuronic Acid; D002118:Calcium