Virus-like particles as a modular system for novel vaccines.
Induction of protective immune responses with recombinant antigens is a major challenge for the vaccine industry. Here we present a molecular assembly system that renders antigens of choice highly repetitive. Using this method, efficient antibody responses may be induced in the absence of adjuvants resulting in protection from viral infection and allergic reactions.
Lechner
Franziska
F
Cytos Biotechnology AG, Zürich, Switzerland.
Jegerlehner
Andrea
A
Tissot
Alain C
AC
Maurer
Patrik
P
Sebbel
Peter
P
Renner
Wolfgang A
WA
Jennings
Gary T
GT
Bachmann
Martin F
MF
D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy; D007167:Immunotherapy; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D014771:Virion / Q000276:immunology*
D000941:Antigens; D014765:Viral Vaccines