[Preliminary experimental study on therapeutic mechanism of kangzhen zhijing capsule in treating Parkinson's disease].
OBJECTIVE
To explore the therapeutic mechanism of Kangzhen Zhijing Capsule (KZZJC) on rats with Parkinson's disease (PD).


METHODS
PD rat model was established by microinjection of 6-hydroxydopamine solution into left substantia nigra zona compacta (SNZC). Model rats were randomly divided into 3 groups and treated with KZZJC, levodopa and normal saline respectively for 30 days. The rotational behavior of rats before and after treatment was observed. Then rats were sacrificed and relevant indexes of left SNZC and striatum were examined.


RESULTS
In rats treated with KZZJC, the rotational behavior was improved (P < 0.05), the levels of dopamine (DA) content and DA/homovanillic acid (HVA) ratio in striatum, and glutathione peroxidase, superoxide dismutase and glutathione in SNZC increased, but malondialdehyde in SNZC decreased, as compared with those in rats treated with normal saline, the difference was significant (P < 0.01 or P < 0.05). Rotational behavior in rats treated by levodopa was improved significantly (P < 0.01).


CONCLUSIONS
KZZJC could partially improve the rotational behavior in PD model rats, increase DA content and DA/HVA ratio in striatum. The mechanism might be the reducing of free radical damage and DA catabolism.
Bao
Y C
YC
Department of Neurology, First Affiliated Hospital, Anhui College of TCM, Hefei 230031.
Wang
H
H
Zhang
B
B
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D008845:Microinjections; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012399:Rotation; D013482:Superoxide Dismutase / Q000378:metabolism
D000978:Antiparkinson Agents; D004365:Drugs, Chinese Herbal; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D004298:Dopamine; D006719:Homovanillic Acid