title: Treatment of toxic epidermal necrolysis with moisture-retentive ointment: a case report and review of the literature.
abstract: Toxic epidermal necrolysis (TEN) is a rare condition that was described by Lyell in 1956. It is a severe, acute, adverse, primarily drug-induced, potentially fatal, cutaneous reaction that is characterized by large areas of skin desquamation and sloughing, similar in many aspects to second-degree burns. The treatment of cutaneous drug reactions rests essentially on immediate diagnosis and recognition of the disease process, accurate history, thorough physical examination, prompt discontinuation of the offending drug, and supportive care. TEN patients are best managed in specialized burn units. Nevertheless, the management remains very much individualized, based on the clinical setting. Topical wound care remains an essential factor in the treatment of burn-like syndromes and is a main determining parameter for morbidity and mortality. As the value of moist environment in wound healing is being fully appreciated, we report on the use of a newly introduced ointment, the Moist Exposed Burn Ointment (Julphar; Gulf Pharmaceutical industries, Ras El-Khaymah, United Arab of Emirutes), a moisture-retentive ointment, in the successful management of a case of TEN.
authors.affiliation: Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Bishara S
authors.initials: BS
authors.lastname: Atiyeh
authors.forename: Ruwayda
authors.initials: R
authors.lastname: Dham
authors.forename: M Fayez
authors.initials: MF
authors.lastname: Yassin
authors.forename: Kusai A
authors.initials: KA
authors.lastname: El-Musa
mesh_terms: D004232:Diuretics / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology; D013449:Sulfonamides / Q000009:adverse effects
chemical_list: D004232:Diuretics; D009824:Ointments; D013449:Sulfonamides