title: [GVHD Following Autologous Peripheral Blood Stem Cell Trasplantation Reduced Malignancy Relapse]
abstract: Administration of the immunosuppressive drug cyclosporine (CSA) after autologous peripheral blood stem cell transplantation (APBSCT) induces a systemic auto-immune syndrome resembling graft-versus-host disease (GVHD), this syndrome termed autologous GVHD has significant antitumor activity, it can reduce the incidence of tumor relapse after APBSCT. The antitumor effect of this auto-aggression syndrome can be enhanced by the administration of gamma-interferon (gamma-IFN). Five consecutive patients who received APBSCT received therapy inducing autologous GVHD. Intravenous administration of CSA [1 mg/(kg.d) for 28 days] was begin on the day of transplantation. gamma-interferon (0.025 mg/m(2) qod) was administered sub-cutaneously from days 7 throngh 28 after transplatation. Results showed that four of five occured autologous GVHD-skin demage, five in control didn't occur autologous GVHD. The relapse rate of the treated cases was 20% (1/5) versus 60% (3/5) of the control, and the median survival time of the treated cases was 20 (4 - 30) months versus 10 (2 - 20) months of the control. The data indicates that autologous GVHD results in low relapse rate of the patients rececving APBSCT.
authors.affiliation: The Fourth People Hospital of Xuzhou of Jiangsu Prouince, Xuzhou 221009, China.
authors.forename: Da-Si
authors.initials: DS
authors.lastname: Guo
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Li
authors.forename: Su
authors.initials: S
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Fu
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Yin