The use of clustering software for the classification of comparative genomic hybridization data. an analysis of 109 malignant fibrous histiocytomas.
Malignant fibrous histiocytoma (MFH) is considered the most frequent soft-tissue sarcoma of late adult life. Nevertheless, the validity of this entity has been recurrently questioned by pathologists. Preliminary analyses by comparative genomic hybridization (CGH) of series of MFH have suggested that this tumor group is heterogeneous at the genomic level, and that at least two main genetic subgroups exist. We report an analysis by CGH of a large series of 109 MFH and on the use of clustering software for an objective classification of these tumors. We confirm our preliminary CGH results and demonstrate that two main clusters of tumors are present in the series analyzed.
Chibon
Frédéric
F
INSERM U509, Molecular Pathology of Cancers, Institut Curie, Paris, France.
Mariani
Odette
O
Mairal
Aline
A
Derré
Josette
J
Coindre
Jean-Michel
JM
Terrier
Philippe
P
Lagacé
Réal
R
Sastre
Xavier
X
Aurias
Alain
A
D016000:Cluster Analysis; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization / Q000379:methods*; D012984:Software