[Long-term toxicity experiment with tea for descending lipid and declining fat].
OBJECTIVE
To investigate the chronic toxicity of tea for descending lipid and declining fat (TDLDF).


METHODS
4 groups Sprague-Dawley rats had respectively been fed with distilled water and TDLDF in 7 g/kg (high dosage), 3.2 g/kg (middle dosage) and 1.5 g/kg(lower dosage) for 12 weeks, the latter were respectively equal to 100, 50 and 20 times clinical dosage. After ig 6, 12 weeks and 3 weeks after discontinuation, the behavior, appetite, excrement and urine, body weight, hematological and biochemical markers, coefficient of the main organs and pathohistological examination of the rats were investigated.


RESULTS
There were no significant differences of the above markers between each experimental group and the control group.


CONCLUSIONS
The clinical recommended dosage of TDLDF is safe.
Lü
Jiangling
J
Guangzhou Academy of TCM, 510130.
Zou
Yihai
Y
Xu
Qin
Q
Zhang
Saixia
S
Zhang
Wei
W
Tang
Shaoling
S
Guan
Huiyun
H
Wang
Xiuyin
X
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D000960:Hypolipidemic Agents / Q000633:toxicity*; D030017:Ilex / Q000737:chemistry*; D031659:Ligustrum / Q000737:chemistry; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents