Inhibitors of apoptosis proteins in injury and disease.
The inhibitor of apoptosis (IAP) gene family prevents cell death by binding to and inhibiting caspases. In addition to negatively regulating apoptosis, IAPs bind to signaling intermediates and receptors, and participate in diverse cellular functions. Here, we describe the physiological functions of IAPs and their participation in injury and disease processes.
Lotocki
George
G
Department of Physiology and Biophysics, University of Miami School of Medicine, P.O. Box 016430, Miami, Florida 33101, USA.
Keane
Robert W
RW
D000818:Animals; D017209:Apoptosis; D004195:Disease Models, Animal; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000502:physiology; D008954:Models, Biological; D005810:Multigene Family; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology; D051616:Neuronal Apoptosis-Inhibitory Protein; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D000077022:Survivin; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta; D051636:X-Linked Inhibitor of Apoptosis Protein
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; C496800:NAIP protein, human; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein; D011506:Proteins; D000077022:Survivin; D016212:Transforming Growth Factor beta; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human