Adapting and validating a NIRS device to measure in utero fetal sheep cerebral oxygenation.
NIRS has provided us with a reliable and sensitive method to monitor in utero fetal cerebral oxygenation in the surgically-recovered pregnant sheep. Our preliminary results indicate that monitoring fetal cerebral oxygenation may be important to understanding how maternal drug exposure can affect the fetal brain.
Reynolds
James D
JD
Duke University Medical Center, Durham, NC 27710, USA.
Amory
David W
DW
Benni
Paul B
PB
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000196:embryology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000097:blood / Q000196:embryology; D007700:Kinetics; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism*; D011247:Pregnancy; D015203:Reproducibility of Results; D012756:Sheep / Q000196:embryology*; D013055:Spectrophotometry, Infrared / Q000379:methods
D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen