title: The serum concentration of estradiol after embryo transfer and the decline from preovulatory levels may influence the success of IVF treatment.
abstract: OBJECTIVE
  To establish the influence that serum estradiol concentrations prior to oocyte retrieval and 3 days after embryo transfer have on the establishment of in vitro fertilization (IVF) pregnancy.
  
  
  METHODS
  Preovulatory (day-0) and luteal-phase (day-6) estradiol concentrations were retrospectively analyzed in 310 infertile patients, undertaking 1st-cycle conventional IVF or intracytoplasmic sperm injection.
  
  
  RESULTS
  The IVF treatment success is significantly reduced in patients with an estradiol level <600 pg/ml and also when a rapid decline in luteal-phase estradiol concentrations from preovulatory concentrations (day 0:day 6 ratio) was exhibited.
  
  
  CONCLUSIONS
  A day 0:day 6 estradiol ratio >5 and a serum estradiol concentration <600 pg/ml may adversely impact on the establishment of pregnancy in IVF.
authors.affiliation: School of Health Science, Griffith University, Gold Coast Campus, Bundall, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Vanderlelie
authors.forename: K
authors.initials: K
authors.lastname: Bell
authors.forename: A V
authors.initials: AV
authors.lastname: Perkins
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D008183:Luteal Phase / Q000502:physiology; D017274:Nafarelin / Q000494:pharmacology; D011247:Pregnancy; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D006728:Hormones; D017274:Nafarelin; D004958:Estradiol