[Antianoxic effects of Dracocephalum tanguticum on brain of mice].
The aqueous extracts i.p. of Dracocephalum tanguticum Maxim (DtM), a Tibetan medicine, prolong sighificantly decapitaion-induced gasping duration in mice and the survival time of mice ligated bilateral carotid (P > 0.01). DtM prolong also the primal gasping in mice after injecting the air into the coccygeal vein (P > 0.01) and the survival time in mice poisoned by Lidocaine (P > 0.05). In addition, DtM is possessed of protecting against the pathologic lession of brain in rats under stimulating high altitude hypoxic condition. The results suggest that DtM has a antianoxic effects on mice.
Hai
P
P
Qinghai High Altitude Medical Science Institute, Xining 810012.
Zhou
S
S
Shang
H
H
Zhao
G
G
D000818:Animals; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D002534:Hypoxia, Brain / Q000188:drug therapy*; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D018609:Tibet
D004365:Drugs, Chinese Herbal