Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms.
Blood levels of superoxide dismutase (SOD), measured by radioimmunometric assay, were compared in 68 patients with chronic schizophrenia and 50 normal control subjects. Psychopathology in the patients was assessed with the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms (SAPS), and the Scale for the Assessment of Negative Symptoms. Blood SOD levels were significantly elevated in schizophrenia compared with control values. SOD levels showed a positive relationship with the BRPS and the SAPS total score in patients.
Zhang
Xiang Yang
XY
Institute of Mental Health, Peking University, Beijing 100083, PR China. zhangxy98@yahoo.com
Zhou
Dong Feng
DF
Cao
Lian Yuan
LY
Zhang
Pei Yan
PY
Wu
Gui Ying
GY
D000328:Adult; D002908:Chronic Disease; D003702:Delusions / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006212:Hallucinations / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013482:Superoxide Dismutase / Q000097:blood*
D005609:Free Radicals; D013482:Superoxide Dismutase