title: Prenatal presentation supports the in utero development of congenital leukemia: a case report.
abstract: Congenital leukemia is a rare disease developing within the first 4 to 6 weeks of life. We report a female infant born with facial mass and multiple subcutaneous nodules. The facial mass was discovered by ultrasound during a routine prenatal examination at the 36th week of gestation. Biopsies were consistent with the diagnosis of acute monoblastic leukemia (AML, FAB M5b). Cytogenetic studies showed 46 XX, t(11;19)(q23;p13.1), which is only found in acute monoblastic leukemia and involves the gene. The infant died at 12 days of age and autopsy revealed a large leukemic tumor burden in several body organs. The discovery of the facial mass prenatally and massive extramedullary leukemic burden support the notion of the in utero development of congenital leukemia.
authors.affiliation: Section of Hematology/Oncology, Columbus Children's Hospital, Ohio 43205, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bayoumy
authors.forename: Tung
authors.initials: T
authors.lastname: Wynn
authors.forename: Altaf
authors.initials: A
authors.lastname: Jamil
authors.forename: Samir
authors.initials: S
authors.lastname: Kahwash
authors.forename: Kathryn
authors.initials: K
authors.lastname: Klopfenstein
authors.forename: Frederick
authors.initials: F
authors.lastname: Ruymann
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D009000:Monocytes / Q000473:pathology; D011296:Prenatal Diagnosis; D012867:Skin / Q000473:pathology; D014178:Translocation, Genetic