title: High-speed cell sorting: fundamentals and recent advances.
abstract: Cell sorters have undergone dramatic technological improvements in recent years. Driven by the increased ability to differentiate between cell types, modern advances have yielded a new generation of cytometers, known as high-speed cell sorters. These instruments are capable of higher throughput than traditional sorters and can distinguish subtler differences between particles by measuring and processing more optical parameters in parallel. These advances have expanded their use to facilitate genomic and proteomic discovery, and as vehicles for many emerging cell-based therapies. High-speed cell sorting is becoming established as an essential research tool across a broad range of scientific fields and is poised to play a pivotal role in the latest therapeutic modalities.
authors.affiliation: Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA. sidrahim@systemsbiology.org
authors.forename: Sherrif F
authors.initials: SF
authors.lastname: Ibrahim
authors.forename: Ger
authors.initials: G
authors.lastname: van den Engh
mesh_terms: D002469:Cell Separation / Q000145:classification / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D064987:Cell- and Tissue-Based Therapy / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005434:Flow Cytometry / Q000145:classification / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D011786:Quality Control