[Anticoagulant, fibrinolytic and antithrombotic effects of the heparin-insulin complex].
Formation of heparin-insulin complex at the 1:10 molar ratio of the components has been demonstrated by spectral methods. The derived complex had anticoagulant, antithrombotic, and fibrinolytic properties of non-enzymatic nature in vitro. Intravenous injection of the complex in the animals (rats) increased anticoagulant and fibrinolytic background and at the same time decreased the plasma coagulation factors fibrinogen and factor XIIIa in the bloodstream. We propose the heparin-insulin complex as a promising antithrombotic drug.
Liapina
L A
LA
Biology Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Pastorova
V E
VE
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D026122:Factor XIIIa / Q000032:analysis / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D046911:Macromolecular Substances; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013057:Spectrum Analysis / Q000379:methods
D000925:Anticoagulants; D004338:Drug Combinations; D005343:Fibrinolytic Agents; D007328:Insulin; D046911:Macromolecular Substances; D005340:Fibrinogen; D006493:Heparin; D026122:Factor XIIIa