[Dietary fat on the procreation of male rats induced by dimethoate].
The effect of dietary fat on the toxicity of dimethoate for the procreation of male rats was observed. Thirty two male rats were divided into 4 groups. 3 groups treated with dimethoate 12.5 mg/(kg.d) for 60 days were fed with high, moderate or low dietary fat respectively. The rats in control group were fed with water and moderate dietary fat. The results showed that serum testosterone(To) and LH and the activity of acid phosphatase and lactate dehydrogenase in testicle were higher in the high or low-fat diet groups than those in the moderate-fat diet group. It suggested that the highor low-fat diet could reduce the degree of harm in the testicle tissue of rats induced by dimethoate than that of moderate-fat diet.
Li
Min
M
Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China.
Shen
Zhilei
Z
Wang
Bingsen
B
Guo
Junsheng
J
D000818:Animals; D000831:Animals, Newborn; D004041:Dietary Fats / Q000008:administration & dosage*; D004117:Dimethoate / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000201:enzymology; D013739:Testosterone / Q000097:blood
D004041:Dietary Fats; D007306:Insecticides; D013739:Testosterone; D007986:Luteinizing Hormone; D010744:Phosphoric Monoester Hydrolases; D004117:Dimethoate