Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.
After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.
Marculescu
Rodrig
R
Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Vanura
Katrina
K
Le
Trang
T
Simon
Paul
P
Jäger
Ulrich
U
Nadel
Bertrand
B
D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D019457:Chromosome Breakage; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic
D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C086540:TAL2 protein, human