[Study on adhesion of platelets to surface of copoly(benzyl glutamate-hydroxy ethyl glutamine)].
Copoly (benzyl glutamate-hydroxy ethyl glutamine) were prepared by partially aminolysis of poly benzyl glutamate with hydroxyl ethylamine at 60 degrees C for predeternined period. As aminolysis was proceeding, the content of hydroxy ethyl glutamine in copolymer increased and the yield of aminolysis decreased. When aminolysis time reached 16.5 hours, a copolymer with 0.357 mole fraction of hydroxy ethyl glutamine was obtained. After 16.5 hours a soluble yellow viscous product of reaction was obtained. The aminolysized specimens displayed more swelling degree in water, that is, more hydrophilits. The meassurement of solid-liquid contact angles showed that an increase in critical surface tention with content of hydroxy ethyl glutamine in copolymer was observed. Likewise a obvious increase in polar component and a slight decrease in dispersive of surface free energy, thus an increase in total surface free energy with content of hydroxy ethyl glutamine was found. The platelet adhesion and deformation test indicated that less platelets were adhered to surfaces of all aminolysized specimens than that of both poly benzyl glutamate and polydimethylsilicone. The least adhered platelets on surface of copolymer with 0.133 mole fraction of content of hydroxy ethyl glutamine were observed. The partiall aminolysis of poly benzyl glutamate films is an effective method to improve its hydrophility and antithrombogenicity.
Pan
Shirong
S
1st Affiliated Hospital, Sun Yet-sen University of Medical Sciences, Guangzhou 510080.
Yi
Wu
W
Wang
Qinmei
Q
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008422:Materials Testing; D010973:Platelet Adhesiveness; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D011817:Rabbits; D013499:Surface Properties
C047494:copoly(gamma-benzylglutamate-gamma-hydroxyethylglutamine); D011099:Polyglutamic Acid