title: [Animal model of immunologic change detection in vivo after xenotransplantation].
abstract: OBJECTIVE
  To review the current condition, test method and progress of the animal model of xeno-graft-versus-host disease(xeno-GVHD).
  
  
  METHODS
  The literature review and comprehensive analysis methods were used in this article.
  
  
  RESULTS
  Implanted immunologic cells, the recepient had the chance of showing host-versus-graft reaction, GVHD or microchimerism. Now, xeno-GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways.
  
  
  CONCLUSIONS
  Chimeric cells is very important to xeno-GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation.
authors.affiliation: Laboratory of Transplant Engineering and Transplant Immunology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041.
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Zhang
authors.forename: You-ping
authors.initials: YP
authors.lastname: Li
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000276:immunology*; D006648:Histocompatibility; D051379:Mice; D018183:Transplantation Chimera; D014183:Transplantation, Heterologous / Q000276:immunology*