title: [Present perspectives on Creutzfeldt-Jakob disease: pathogenesis, diagnosis and treatment].
abstract: In recent years, interest in the group of diseases generically known as "transmissible spongiform encephalopathies" has reemerged, mainly due to the socioeconomic implications of one of its variants: bovine spongiform encephalopathy. Transmissible spongiform encephalopathies seem to be caused by proteinaceous particles called prions, isoforms of a membrane protein which can be found in humans as well as in several animal species. Their precise function is still unknown. Although investigation into transmissible spongiform encephalopathies has clarified some uncertainties about its pathogenesis and epidemiology, many important questions remain. This is especially true or treatment, since no effective curative therapy exists as yet.
authors.affiliation: Servicio de Microbiología, Hospital Universitario de la Princesa, Diego de León no 62, 28006 Madrid.
authors.forename: P
authors.initials: P
authors.lastname: Vargas
authors.forename: M
authors.initials: M
authors.lastname: López-Brea
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D011328:Prions / Q000235:genetics
chemical_list: D011328:Prions