Return of the chalones.
Members of the TGFbeta superfamily play many roles in embryonic development and adult tissue homeostasis. Now recent work focused on growth and differentiation factors (GDFs) suggest that these TGFbeta-like molecules may also control organ size and may, in fact, be the long sought after chalones, or negative growth regulators.
Gamer
Laura W
LW
Department of Oral and Developmental Biology, Harvard School of Dental Medicine and The Forsyth Institute, Boston, MA 02115, USA.
Nove
John
J
Rosen
Vicki
V
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division / Q000502:physiology; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D016212:Transforming Growth Factor beta / Q000502:physiology
D006131:Growth Inhibitors; D016212:Transforming Growth Factor beta