title: 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
abstract: A series of 2-phenylspiroindenes was prepared. The most active analogue (2) was found to be comparable in potency to raloxifene (1) as an estrogen receptor ligand.
authors.affiliation: Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blizzard
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Morgan
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Katalin
authors.initials: K
authors.lastname: Frisch
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
mesh_terms: D000478:Alkylation; D000818:Animals; D001894:Borohydrides; D018360:Crystallography, X-Ray; D006801:Humans; D066298:In Vitro Techniques; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D020849:Raloxifene Hydrochloride / Q000494:pharmacology; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects; D020845:Selective Estrogen Receptor Modulators / Q000138:chemical synthesis* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C476325:2-Phenylspiroindene; D001894:Borohydrides; D007192:Indenes; D007202:Indicators and Reagents; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D013141:Spiro Compounds; D020849:Raloxifene Hydrochloride; C025364:sodium borohydride