title: A fluorescent sensor with high selectivity and sensitivity for potassium in water.
abstract: This communication describes a new optical sensor suitable for practical measurement of extracellular (serum or whole blood) potassium. The sensor responds rapidly and reversibly to changes in potassium concentrations typical of whole blood samples. No interferences from clinical concentrations of calcium or pH are observed, and the sodium interference is very minor. Excitation and emission occur in the visible light region. This new potassium sensor is currently used in the Roche OPTI CCA, a commercially available whole blood analyzer.
authors.affiliation: Roche Diagnostic Corporation, 235 Hembree Park Drive, Roswell, Georgia 30076, USA.
authors.forename: Huarui
authors.initials: H
authors.lastname: He
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mortellaro
authors.forename: Marc J P
authors.initials: MJ
authors.lastname: Leiner
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fraatz
authors.forename: James K
authors.initials: JK
authors.lastname: Tusa
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D004988:Ethers, Cyclic / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007476:Ionophores / Q000138:chemical synthesis / Q000737:chemistry; D007700:Kinetics; D053644:Naphthalimides; D011188:Potassium / Q000032:analysis* / Q000097:blood; D015363:Quinolones / Q000737:chemistry; D012680:Sensitivity and Specificity; D012996:Solutions; D013050:Spectrometry, Fluorescence / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D004988:Ethers, Cyclic; D005456:Fluorescent Dyes; D007476:Ionophores; D053644:Naphthalimides; D015363:Quinolones; D012996:Solutions; D014867:Water; C086538:4-amino-1,8-naphthalimide; D015057:1-Naphthylamine; D011188:Potassium