[Clinical randomized double-blinded study on treatment of vascular dementia by jiannao yizhi granule].
OBJECTIVE
To observe the effect of Chinese herbal medicine in treating vascular dementia (VD) and to explore the method for therapeutic effect evaluation.


METHODS
Multi-center, double-blinded randomize-controlled method was adopted to observe the effect of treatment of 242 patients with VD of mild or middle degree, they were 89 cases in the TCM group, 106 cases in the western medicine group and 47 in the placebo group. Minimental state examination (MMSE), Blessed dementia scoring on TCM symptom classified evaluation were used to evaluate the therapeutic effect after 60 days treatment.


RESULTS
The total effective rate of Jiannao Yizhi Granule was 58.4%, showing a better effect than that of the placebo group and the western medicine group respectively. The treatment was superior in holistic regulation and systemic functional state improvement, it could not only improve the mild middle key symptoms of VD and the mental disorder induced reduction of functional activities, but also alleviate or eliminate the peripheral symptoms of VD.


CONCLUSIONS
The effect of treatment of vascular dementia by Jiannao Yizhi Granule is certain and is worth spreading.
Zhang
Bo-li
BL
Tianjin TCM College, Tianjin 300193.
Wang
Yong-yan
YY
Chen
Ru-xing
RX
D000368:Aged; D015140:Dementia, Vascular / Q000188:drug therapy*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal