title: A 2-year prospective study on the effects of depot medroxyprogesterone acetate on bone mass-response to estrogen and calcium therapy in individual users.
abstract: The primary aim of this prospective 2-year follow-up study was to investigate the effect of depot medroxyprogesterone acetate (DMPA) on the maintenance of bone mass in women aged 30-45 years. The effects of estrogen or calcium substitution during the second year of follow-up was investigated in seven DMPA users with a high annual bone loss during the first year. The bone mass of 35 users of DMPA and 10 women without hormonal contraception was investigated using peripheral quantitative computed tomography. The baseline cortical and trabecular bone mass (TBM) and the annual change was not different in DMPA users and controls. Over 24 months we measured an increase in TBM of 0.6% and a decrease in cortical bone mass of 0.1% in exposed women. Some but not all of the DMPA users with a bone loss during the first year could be successfully treated with estradiol or calcium. In conclusion, we did not observe an accelerated bone loss in DMPA users aged 30-45 years.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital, CH-8091, Zurich, Switzerland. gabriele.merki@fhk.usz.ch
authors.forename: Gabriele S
authors.initials: GS
authors.lastname: Merki-Feld
authors.forename: Maurus
authors.initials: M
authors.lastname: Neff
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Keller
mesh_terms: D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000627:therapeutic use*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D003692:Delayed-Action Preparations; D019587:Dietary Supplements; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000139:chemically induced / Q000517:prevention & control; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate; D002118:Calcium