title: The apo A-I gene promoter region polymorphism determines the severity of hyperlipidemia after heart transplantation.
abstract: BACKGROUND
  To study whether the Apolipoprotein A-I (apo A-I) promoter region gene polymorphism produces changes in the lipid profile of heart transplant recipients.
  
  
  METHODS
  One hundred and three heart transplant recipients (93 men and 10 women, with a mean age of 47 +/- 13 yr) receiving triple immunosuppressive therapy were submitted to a genetic study of the apo A-I gene promoter region. Anthropometric and analytical data, including lipid profile, arterial blood pressure, were collected prior to transplantation and 3, 6, 12, and 24 months after transplantation.
  
  
  RESULTS
  Sixty-three subjects had the GG genotype and 40 the GA genotype. Carriers of the GA genotype had higher triglyceride levels at 6 months and 2 yr (2.50 +/- 1.20 versus 1.93 +/- 0.98 mmol/L and 2.46 +/- 1.58 versus 1.60 +/- 0.68 mmol/L, respectively, p < 0.001), and a greater rise in LDL-cholesterol at 1 yr than the GG subjects (4.57 +/- 1.16 versus 4.16 +/- 1.18 mmol/L, p < 0.05). Multiple regression analyses showed that genetic variants at the apo A-I promoter region are responsible for 11% of the variability in triglyceride levels at 6 months (p = 0.005).
  
  
  CONCLUSIONS
  The GA genotype of the apo A-I promoter region produces a greater rise in plasma triglyceride and LDL-cholesterol levels in heart transplant patients.
authors.affiliation: Unidad de Lípidos y Arteriosclerosis, Departamento de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: González-Amieva
authors.forename: José
authors.initials: J
authors.lastname: López-Miranda
authors.forename: Carmen
authors.initials: C
authors.lastname: Marín
authors.forename: Pablo
authors.initials: P
authors.lastname: Pérez-Martinez
authors.forename: Purificación
authors.initials: P
authors.lastname: Gómez
authors.forename: Elier
authors.initials: E
authors.lastname: Paz-Rojas
authors.forename: Josè M
authors.initials: JM
authors.lastname: Arizón
authors.forename: José A
authors.initials: JA
authors.lastname: Jiménez-Perepérez
authors.forename: Manuel
authors.initials: M
authors.lastname: Concha
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Jiménez
mesh_terms: D016632:Apolipoprotein A-I / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005260:Female; D005838:Genotype; D016027:Heart Transplantation; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000235:genetics*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011446:Prospective Studies
chemical_list: D016632:Apolipoprotein A-I; D007166:Immunosuppressive Agents