[Triterpenoid saponins from Eclipta prostrata L].
OBJECTIVE
To study the triterpenoid saponins in the Chinese traditional medicine Eclipta prostrata L..


METHODS
Column chromatography with silica gel and HPLC were employed for the isolation and purification. The molecular structures were determined on the basis of spectral analysis (IR, MS, 1HNMR, 13CNMR, HMQC and HMBC).


RESULTS
Two new triterpenoid saponins, named eclalbasaponins XI (4) and XII (5), were obtained and their structures were elucidated as 3-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-16 alpha-ethoxy-olean-12-ene-28-oic acid-28-O-beta-D-glucopyranoside and 3-O-[(2-O-sulfuryl-beta-D-glucopyranosyl) (1-->2)-beta-D-glucopyranosyl]-echinocystic acid-28-O-beta-D-glucopyranoside, respectively, along with three known saponins, eclalbasaponins II (1), I (2) and III (3).


CONCLUSIONS
Compounds 4 and 5 are new compounds, 1 and 5 induced morphological deformation of Pyricularia oryzae mycelia.
Zhao
Y P
YP
Department of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Tang
H F
HF
Jiang
Y P
YP
Wang
Z Z
ZZ
Yi
Y H
YH
Lei
Q Y
QY
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay; D036601:Eclipta / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C481166:3-O-((2-O-sulfurylglucopyranosyl)-1-2-glucopyranosyl)-echinocystic acid 28-O-glucopyranoside; C481165:3-O-(glucopyranosyl-1-2-glucopyranosyl)-16-ethoxyolean-12-ene-28-oic acid 28-O-glucopyranoside; D000935:Antifungal Agents; D012503:Saponins