[Studies on the antimutagenic effect of asparagus juice].
Micronucleus (MN) test, sister chromatid exchanges (SCE) and sperm malformation test were used to study the effects of asparagus juice on the mutagenic activity of cyclophosphamide (CP). It was found that, asparagus juice itself showed no effcet on the incidence of MN, SCE and sperm malformation, but asparagus juice reduced the incidence of MN (from 60.0@1000 to 50.3@1000-26.6@1000), SCE (from 29.22 times/cell to 26.40-13.37 times/cell) and sperm malformation (from 61.0@1000 to 51.2@1000-28.6@1000) induced by CP respectively. The inhibitory effects showed a dose dependent relation, which was statistically significant.
Tang
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Yancheng Normal College, Jiangsu 224002.
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects; D014675:Vegetables / Q000737:chemistry
D016587:Antimutagenic Agents; D010936:Plant Extracts; D003520:Cyclophosphamide