[From clinical medicine to molecular genetics: the new outlook of hereditary muscular dystrophies].
The introduction of molecular genetics has deeply transformed the field of hereditary neuro-muscular disorders. This is illustrated by the example of non-myotonic muscular dystrophies. From five classically described entities on a clinico-pathological basis, the number of disorders identified on a genic and molecular basis is to-day about fourty. The consequences of this growing complexity should be carefully analyzed on clinical and nosographical grounds.
Fardeau
Michel
M
L'Institut de Myologie-Hôpital de La Salpêtrière-Bâtiment Babinski-83, Bd de l'Hôpital-75651 Paris.
D015510:Clinical Medicine; D006801:Humans; D008967:Molecular Biology; D009136:Muscular Dystrophies / Q000235:genetics* / Q000628:therapy*