title: [Study on the coagulation state of sudden deafness].
abstract: OBJECTIVE
  To explore the coagulation, anticoagulation and fibrinolyic activity in sudden deafness (SD).
  
  
  METHODS
  The plasma samples from 42 patients with SD before treatment, 23 patients after treatment and 32 normal controls were examined for coagulation factors, anticoagulation, fibrinolyic activity and platelet functions.
  
  
  RESULTS
  The functions of coagulation and platelet enhanced, the functions of anticoagulation and fibrinolyic system decreased in 42 patients with SD before treatment. We treated with vitamin, dextranum, energetic compound, vasodialator, antiviral ect in 23 patients for a month. The functions of coagulation, anticoagulation and platelet were no significant difference between the after treatment group and control group (P > 0.05). The level of D-dimer obviously elevated (P < 0.01).
  
  
  CONCLUSIONS
  The functions of coagulation and platelet enhanced, the functions of anticoagulation and fibrinolyic system decreased in SD before treatment, The secondary fibrinolyic activity enhanced after treatment. The thrombosis is one of important pathogenesis of SD.
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000.
authors.forename: M S
authors.initials: MS
authors.lastname: Wang
authors.forename: X X
authors.initials: XX
authors.lastname: Wang
authors.forename: X D
authors.initials: XD
authors.lastname: Chen
authors.forename: J F
authors.initials: JF
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood