title: Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models with infusion regimen.
abstract: A lag time may exist between blood drug concentration and drug effect. Various factors can contribute to the lag time, among which the drug distribution delay is a significant one. The drug distribution delay can also exist between different compartments. An equation was derived to calculate the steady-state drug concentration delay between central and peripheral compartments in a two-compartment model with infusion regimen.
authors.affiliation: Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille 11, Marseille, France.
authors.forename: Guang
authors.initials: G
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D005583:Fourier Analysis; D006020:Glycopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics; D007262:Infusions, Intravenous / Q000706:statistics & numerical data*; D008954:Models, Biological; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014018:Tissue Distribution; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D006020:Glycopeptides; D004364:Pharmaceutical Preparations; D014640:Vancomycin