Evaluation of anti-diarrheal activity of Cleome viscosa L. extract in rats.
A study was undertaken to evaluate the effect of a methanol extract of the entire plant Cleome viscosa L. (CVME) (Family; Capparidaceae) for its anti-diarrheal potential against some of the experimental models of diarrhea in rats. CVME showed significant inhibitory activity against castor-oil-induced diarrhea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastrointestinal motility in the charcoal meal test in rats. The results obtained establish the efficacy and substantiate the folklore claim as an anti-diarrheal agent.
Devi
B Parimala
BP
Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta, India.
Boominathan
R
R
Mandal
S C
SC
D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002368:Castor Oil; D002606:Charcoal; D031485:Cleome; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000930:Antidiarrheals; D010936:Plant Extracts; D002606:Charcoal; D002368:Castor Oil; D015232:Dinoprostone