Hydrops fetalis secondary to parvovirus B19 infections.
BACKGROUND
Fetal infection by human parvovirus B19 is a common cause of fetal anemia, nonimmune hydrops fetalis, and spontaneous abortion and can result in fetal death. Recent improvements in diagnosing parvovirus infections and the availability of intrauterine transfusion have reduced the overall rate of fetal loss after maternal exposure.


METHODS
We report two cases of maternal parvovirus infection with classic findings of hydrops fetalis and review various aspects of parvovirus infection with emphasis on the developing management options in pregnancy.


CONCLUSIONS
Different management led to different results. In the first case there was normal neonatal and infantile development, and in the second case, the fetus died. With accurate laboratory testing, obstetric sonography, and fetal transfusion, the fetal mortality from parvovirus infection has been reduced considerably, and most pregnancies complicated by maternal parvovirus infection result in healthy outcomes.
Xu
Jin
J
Department of Family Medicine, The Reading Hospital and Medical Center, Reading, PA, USA.
Raff
Thomas C
TC
Muallem
Nabil S
NS
Neubert
A George
AG
D000328:Adult; D005260:Female; D005313:Fetal Death; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology*; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome