[Autoantibodies to the heterogeneous nuclear ribonucleoproteins and the autoimmune diseases].
Autoantibodies to the heterogeneous nuclear ribonucleoproteins (hnRNP) have a great role in the diagnosis of rheumatic diseases. hnRNP-A/B proteins are the main autoantigens in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD). Anti-RA33 autoantibodies which target the hnRNP proteins A2, B1, B2 (the 'RA33 complex') help to the diagnosis of RA at early stage. Therefore, anti-hnRNP autoantibodies are not only valuable diagnostic markers but may also allow deep insights into the pathogenetic mechanisms of rheumatic diseases.
Yang
L
L
Department of Rheumatology, PUMC Hospital, CAMS and PUMC, Beijing 100730.
Yu
M
M
Yang
C
C
D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008947:Mixed Connective Tissue Disease / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D034441:Heterogeneous-Nuclear Ribonucleoproteins