title: [Study on the structural property of polysacchrides 139A--a kind of IL-1R antagonists from microorganism].
abstract: OBJECTIVE
  To study the structural property of the bioactive component from the fermentation broth of Streptomyces 139 which can inhibit IL-1R.
  
  
  METHODS
  Polysaccharide 139A is extracted and purified by means of macroreticular resin Diaion HP-20, cation exchange and DEAE Sephadex A-25 chromatography. The sugar compositions were analyzed with GC, the linkage positions of 139A were determined by methylation and GC-MS.
  
  
  RESULTS
  The bioactive component which can inhibit IL-1R is a kind of polysaccharides.
  
  
  CONCLUSIONS
  The components of 139A repeat units are conjectured.
authors.affiliation: Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: J B
authors.initials: JB
authors.lastname: Wu
authors.forename: Y M
authors.initials: YM
authors.lastname: Liu
authors.forename: G Y
authors.initials: GY
authors.lastname: Xu
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D008745:Methylation; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D011135:Polysaccharides, Bacterial; D017472:Receptors, Interleukin-1