The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare.
Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.
El Bardai
Sanae
S
Morel
Nicole
N
Wibo
Maurice
M
Fabre
Nicolas
N
Llabres
Gabriel
G
Lyoussi
Badiaa
B
Quetin-Leclercq
Joëlle
J
D000818:Animals; D001011:Aorta; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D027522:Marrubium / Q000737:chemistry*; D009018:Morocco; D010946:Plants, Medicinal; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*
D004224:Diterpenes; D005663:Furans; C473344:marrubenol; D011189:Potassium Chloride; C105731:marrubiin