Evaluation of treatment by pulsed electromagnetic fields in a rabbit hyphema model.
OBJECTIVE
Previous clinical studies have suggested a positive effect of low-frequency pulsed electromagnetic fields (PEMF) on wound healing and inflammation in the eye. We tried to test the value of PEMF treatment in a hyphema animal model with well-defined conditions.


METHODS
After injection of citrated autologous blood for the production of hyphema, 16 rabbit eyes were treated with 10 or 20 mT for 60 min on 4 days within the postoperative week. Two control groups with hyphema alone (n = 8) and PEMF irradiation without hyphema (n = 4) were also included. The rate of resorption was recorded daily. Histopathologic evaluation was performed.


RESULTS
The incidence of endothelial cell damage and fibrotic clots was markedly reduced in the 10-mT group while the resorption time of 8 days was identical with the control group. In the 20-mT group, the complication rate and the resorption time was increased versus the control group.


CONCLUSIONS
The use of PEMF treatment is of some, however, limited value as it did not reduce the resorption time of hyphema but displayed a dose-dependent, beneficial influence on some serious side effects. Future clinical studies with low-dose PEMF irradiation are justified and should determine the optimal dosage and suitable indications of PEMFs as an adjunctive treatment in ocular inflammation or trauma.
Wollensak
Gregor
G
Department of Ophthalmology, Universitätsklinikum CGC, Dresden, Germany. gwollens@hotmail.com
Muchamedjarow
Felix
F
Funk
Richard
R
D000818:Animals; D000869:Anterior Eye Segment / Q000528:radiation effects*; D004195:Disease Models, Animal; D004574:Electromagnetic Fields; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D006988:Hyphema / Q000473:pathology / Q000628:therapy*; D011817:Rabbits; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects*