[Imitative restenosis after percutaneous transluminal coronary angioplasty prevented by buyang huanwu decoction in rabbits].
OBJECTIVE
To examine the preventive effect of Buyang Huanwu Decoction (BYHWD) on imitative restenosis after percutaneous transluminal coronary angioplasty (PTCA) in diet-induced atherosclerotic rabbits.


METHODS
Diet-induced atherosclerotic rabbits were randomly allocated into group 1 (n = 24, fed with BYHWD one week before and 4 weeks after the operation, 2 ml/kg per day, containing herbal drug 8.4 g/ml) and group 2 (n = 20, as control). Balloon angioplasty was performed in the abdominal arota to mimic coronary angioplasty.


RESULTS
Sixty days after operation: (1) Incidence of hyperplasia of the intima was 7/24 (29.2%) in group 1 vs 17/20 (85.0%) in group 2, P < 0.01; (2) Comparison of area of hyperplastic intima was (0.54 +/- 0.21) mm2 vs (1.67 +/- 0.75) mm2, P < 0.01; (3) Area of hyperplastic intima/area of lumen (limited by the internal elastic membrane was (18.0 +/- 7.2)% vs (56.0 +/- 17.1)%, P < 0.01; (4) Intact lumen/dilated lumen was (0.74 +/- 0.03) vs (0.35 +/- 0.07), P < 0.01; (5) Effect of serum taken from group 1 on cultured smooth muscle cells showed by 3H-TdR method was (4110.14 +/- 1977.01) cpm, which was significantly less than that of serum taken from group 2 [(7960.14 +/- 2802.59) cpm, P < 0.05].


CONCLUSIONS
BYHWD has significant preventive effect on the imitative post PTCA restenosis in diet-induced atherosclerotic rabbits.
Hou
C
C
Sun Yat-sen University of Medical Sciences, Guangzhou 510089.
He
Q
Q
Li
S
S
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy*; D023903:Coronary Restenosis / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D017539:Tunica Intima / Q000473:pathology
D004365:Drugs, Chinese Herbal; C460102:buyang huanwu