title: Gas chromatography with mass spectrometric, atomic emission and Fourier transform infrared spectroscopic detection as complementary analytical techniques for the identification of unknown impurities in pharmaceutical analysis.
abstract: An example of the complementary use of GC-MS. GC-AED and GC-FT-IR is described for efficient structure elucidation of an unknown impurity in pharmaceutical analysis. None of the analytical techniques could solve the structure of the unknown impurity alone; identification was, however, straightforward by combining the available spectroscopic information. GC-MS provided information about structural fragments and molecular mass of the unknown compound. GC-AED was used for confirmation of the occurrence of the individual elements in the structure and to enable calculation of the empirical formula. GC-FT-IR gave valuable information regarding functional groups in the molecule.
authors.affiliation: AstraZeneca, Process R&D, Department of Analytical Chemistry, SE- 151 85 Södertälje, Sweden. krzysztof.laniewski@astrazeneca.com
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Laniewski
authors.forename: Thomas
authors.initials: T
authors.lastname: Wännman
authors.forename: Gunnar
authors.initials: G
authors.lastname: Hagman
mesh_terms: D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012015:Reference Standards; D013054:Spectrophotometry, Atomic / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations