[A study of HGV infection in liver tissue of hepatocellular carcinoma].
OBJECTIVE
To investigate the prevalence of hepatitis G virus (HGV) in hepatocellular carcinoma (HCC).


METHODS
HGV NS5 antigen was detected in paraffin-embedded HCC tissues from 53 autopsy patients by using immunohistochemical method with antiHGV NS5 monoclonal antibody.


RESULTS
Among the 53 subsjects, 20(37.7%) had been detected of HGV antigen (HGAg) in HCC tissues. When serological markers were used, the HGAg detection rate was 2/8(25%) in non-B and non-C, 16/41(39%) in HBV and 2/2 in HCV infection groups, respectively.


CONCLUSIONS
The infection of HGV is often seen in patients with HCC. HGV infection does not appear to account for an important independent risk factor for development of HCC.
Liao
H
H
Youan Hospital, Beijing 100054.
Lang
Z
Z
Zhu
R
R
D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D018178:Flaviviridae Infections / Q000821:virology*; D029407:GB virus C / Q000276:immunology / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000821:virology; D006801:Humans; D008099:Liver / Q000821:virology*; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D017361:Viral Nonstructural Proteins / Q000032:analysis*
D000956:Antigens, Viral; C096041:NS5 protein, flavivirus; D017361:Viral Nonstructural Proteins