[Study of the inclusion compound of rutin with beta-cyclodextrin].
In order to improve the solubility of Rutin in aqueous solution and the stability, the inclusion compound of Rutin with beta-CD was manufacted by saturated aqueous solution method. The formation of the inclusion compound was confirmed by IR spectroscopy and differential scauning calorimetry. The content of Rutin in inclusion compound was determined by UV. The results indicated that the inclusion compound of Rutin with beta-CD was formed. Quantitative analysis demmonstrated that the molecular ratio of Rutin to beta-CD in the complex was 1:1 with the inclusion constant of 283.79 L/mol at 30 degrees C. The dissolubility of Rutin in water has added to 643.19 mg/L (20 degrees C).
Shao
W
W
Department of Pharmacy, Shandong Medical University, Jinan 250012.
Wang
D
D
Mi
G
G
Wang
C
C
D001682:Biological Availability; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D012431:Rutin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D012431:Rutin; C031215:betadex