Adult stroke and perinatal brain damage: like grandparent, like grandchild?
Biomarkers of inflammation are found in the circulation of adults who have had a stroke. Although these biomarkers may, in part, be indicators of damage, some appear to contribute to damage. Similar biomarkers are found in newborns with cerebral white matter damage or at risk of cerebral palsy. Can we learn about the pathogenesis of neonatal white matter damage from what has been learned about the inflammatory correlates of adult stroke? We discuss relevant findings about systemic inflammatory markers in adult stroke and relate this information to our current understanding of cerebral white matter damage in newborns, especially those born at an extremely low gestational age. We also describe desirable characteristics of future studies of perinatal brain damage that involve measurements of systemic biomarkers.
Leviton
A
A
Neuroepidemiology Unit, Children's Hospital, Boston, MA, USA.
Dammann
O
O
O'Shea
T M
TM
Paneth
N
N
D000328:Adult; D000368:Aged; D000818:Animals; D001925:Brain Damage, Chronic / Q000276:immunology*; D002544:Cerebral Infarction / Q000276:immunology*; D002547:Cerebral Palsy / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000276:immunology*; D019102:Infant, Very Low Birth Weight / Q000276:immunology*; D018836:Inflammation Mediators / Q000097:blood*; D007962:Leukocytes / Q000276:immunology; D012307:Risk Factors
D018836:Inflammation Mediators