title: [Hemorheology of island flap after ischemia-reperfusion injury and modulation of dexamethasone].
abstract: OBJECTIVE
  To study the hemorheology of island flap after ischemia-reperfusion injury and modulation of dexamethasone.
  
  
  METHODS
  Sixty Wister rats were made ischemia-reperfusion injury model, and divided into two groups randomly(Group I: intraperitoneal injection of normal saline 2 ml/kg as control group; Group II: intraperitoneal injection of dexamethasone 5 mg/kg as experimental group). Flap survived areas were measured and neutrophil necrosis numbers in flaps were counted. Erythrocytes and neutrophil hemorheology were observed.
  
  
  RESULTS
  Area survived flap in group II was larger than that in group I. Neutrophil necrosis numbers were less in group II than in group I (P < 0.05). Whole blood hyposhear viscosity, erythrocyte aggregation, Casson yield stress and nerutrophil adhesion ability were higher in group I than in group II (P < 0.05); and the neutrophil deformability was lower in group I than in group II.
  
  
  CONCLUSIONS
  Flap inchemia-reperfusion can increase erythrocyte aggregation index and neutrophil adhesion ability. Dexamethasone can improve these and decrease neutrophil necrosis numbers, so as to prevent flap from ischemia-reperfusion injury.
authors.affiliation: Department of Plastic Surgery, General Hospital of Jinan Military Command, Jinan, Shangdong, P. R. China 250031.
authors.forename: Jing-min
authors.initials: JM
authors.lastname: Cao
authors.forename: Kai-hua
authors.initials: KH
authors.lastname: Lu
authors.forename: Biao
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006085:Graft Survival; D018056:Hemorheology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D013524:Surgical Flaps / Q000098:blood supply*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone