[Study on the metabolism of psuedo-ginsenoside F11 in rats].
OBJECTIVE
To study the metabolic pathways of psuedo-ginsenoside F11 in rats.


METHODS
By use of the prep-TLC, the metabolites were isolated.


RESULTS
From the feces, three metabolites, psuedo-ginsenoside-RT5, ocotillol, and a new compound, F-3-1 (44) were isolated and identified by means of NMR evidence. But, such metabolites were found from neither the bile nor the urine of the rat. F-3-1 was identified as 6-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl-(20S,23S,24R)- dammar-20(24)-epoxy-3 beta, 6 alpha, 12 beta, 23,25-pentanol.


CONCLUSIONS
Psuedo-ginsenoside-F11 can not be metabolized in the rat liver, but can be metabolized in the large intestine of the rat.
Wang
J H
JH
Shenyang Pharmaceutical University, Shenyang 110015, China.
Li
X
X
D000818:Animals; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D036145:Ginsenosides / Q000302:isolation & purification / Q000378:metabolism*; D007420:Intestine, Large / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification
C481913:6-O-rhamnopyranosyl-1-2-glucopyranosyldammar-20(24)-epoxy-3,6,12,23,25-pentanol; D036145:Ginsenosides; D012503:Saponins; C413985:pseudoginsenoside F11