title: Fatigue strength of PMMA bone cement mixed with gentamicin and barium sulphate vs pure PMMA.
abstract: Barium sulphate is added to polymethylmethacrylate (PMMA) bone cement as a radiopacifier. Gentamicin is an antibiotic added to bone cement to treat or prevent infection in arthroplasty. This study investigated the combined effect of barium sulphate and gentamicin sulphate on the fatigue strength of PMMA bone cement. Three different formulations were studied: pure PMMA, PMMA with barium sulphate added and PMMA with barium sulphate and gentamicin sulphate added. Before testing all specimens were stored in water at 37 degrees C for at least 15 days to season the PMMA and to elute the antibiotic. Fatigue tests were performed following a previously validated procedure. The slope part of the Wöhler diagram was obtained and a rough endurance limit was estimated for all three formulations. The experimental data showed that the addition of barium sulphate to PMMA bone cement affected the fatigue strength of the material, whereas addition of gentamicin sulphate to the radiopaque PMMA had no effect on the fatigue properties of the bone cement. While PMMA with barium sulphate added was confirmed to have a reduced fatigue strength when compared with plain PMMA, no detrimental effect was found for the addition of gentamicin sulphate to radiopaque PMMA.
authors.affiliation: Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Baleani
authors.forename: L
authors.initials: L
authors.lastname: Cristofolini
authors.forename: C
authors.initials: C
authors.lastname: Minari
authors.forename: A
authors.initials: A
authors.lastname: Toni
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001466:Barium Sulfate / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D002484:Cementation / Q000379:methods*; D003287:Contrast Media / Q000737:chemistry; D005839:Gentamicins / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods* / Q000592:standards; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength; D016474:Weight-Bearing
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D003287:Contrast Media; D005839:Gentamicins; D001466:Barium Sulfate