[Effect of liposomal albendazole on the ultrastructure of Echinococcus granulosus cysts in mice].
OBJECTIVE
To observe the histopathological changes of Echinococcus granulosus cysts in mice treated with liposomal albendazole and co-administration with cimetidine by light microscopy and electron microscopy.


METHODS
An oral dose of liposomal ABZ with different formulations was given at 200 mg/kg.d. Cimetidine was administered daily at an oral dose of 100 mg/kg.d. Sixty-seven mice were orally given different drugs six days per week for a total of twelve weeks.


RESULTS
The histopathological changes indicated that there were significant differences (P < 0.01) between treated groups and control group. The degeneration and necrosis of E. granulosus cysts were marked in liposomal albendazole combined with cimetidin group.


CONCLUSIONS
Liposomal albendazole was more effective against E. granulosus cyst than albendazole. Cimetidine had an apparent synergistic effect when given in combination with liposomal albendazle.
Shao
Y
Y
Department of General Surgery, First Teaching Hospital, Xingjiang Medical College, Urumqi 830000.
Liu
W
W
Wen
H
H
D015766:Albendazole / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003560:Cysts / Q000188:drug therapy; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D048209:Echinococcus granulosus / Q000187:drug effects* / Q000648:ultrastructure; D048210:Echinococcus multilocularis / Q000187:drug effects; D005260:Female; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron
D000923:Anticestodal Agents; D008081:Liposomes; D015766:Albendazole