No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study.
A recent family-based association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. This study used a sample of 270 Irish pedigrees multiply affected with schizophrenia. We attempted to replicate these findings in an independent Irish sample of 219 schizophrenia cases and 231 controls. No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed.
Morris
Derek W
DW
Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland. morrisdw@tcd.ie
McGhee
Kevin A
KA
Schwaiger
Siobhan
S
Scully
Paul
P
Quinn
John
J
Meagher
David
D
Waddington
John L
JL
Gill
Michael
M
Corvin
Aiden P
AP
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005787:Gene Frequency; D005819:Genetic Markers; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007494:Ireland; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers