title: Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.
abstract: Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was administered to 50 male and 50 female Sprague-Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L. Animals were kept under observation until spontaneous death. Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues.
authors.affiliation: Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. crcfr@tin.it
authors.forename: Morando
authors.initials: M
authors.lastname: Soffritti
authors.forename: Fiorella
authors.initials: F
authors.lastname: Belpoggi
authors.forename: Luca
authors.initials: L
authors.lastname: Lambertin
authors.forename: Michelina
authors.initials: M
authors.lastname: Lauriola
authors.forename: Michela
authors.initials: M
authors.lastname: Padovani
authors.forename: Cesare
authors.initials: C
authors.lastname: Maltoni
mesh_terms: D000079:Acetaldehyde / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000145:classification / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002273:Carcinogens; D005557:Formaldehyde; D000079:Acetaldehyde