title: Genomic approaches to identification of tumour-susceptibility genes using mouse models.
abstract: Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The sequencing of the mouse genome provides new approaches to one of the most challenging tasks of cancer genetics today.
authors.affiliation: University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA. jmao@cc.ucsf.edu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Mao
authors.forename: Allan
authors.initials: A
authors.lastname: Balmain
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D040641:Quantitative Trait Loci