title: Cervical light-induced fluorescence in humans decreases throughout gestation and before delivery: Preliminary observations.
abstract: OBJECTIVE
  The purpose of this study was to investigate gestational changes of cervical light-induced fluorescence, an index of cross-linked collagen, and the relationship between light-induced fluorescence and the time-to-delivery interval.
  
  
  METHODS
  Fifty patients were included in one of two groups. (1) Twenty-one healthy pregnant women without signs of labor underwent repeated cervical light-induced fluorescence measurement during the last trimester. (2) Light-induced fluorescence was measured in 29 patients with signs of labor, and the time from measurement to delivery was noted. Cervical light-induced fluorescence was obtained noninvasively with a prototype instrument that was designed specifically for this purpose. Spearman correlation and the Student t test and receiver-operator characteristics analysis were performed (P <.05).
  
  
  RESULTS
  Light-induced fluorescence correlated negatively with gestational age and positively with time-to-delivery interval, was significantly lower in patients who were delivered <24 hours compared with those patients who were delivered >24 hours later, and was predictive of delivery within 24 hours.
  
  
  CONCLUSIONS
  Cervical light-induced fluorescence decreases significantly as gestational age increases. Light-induced fluorescence may be a useful tool to identify patients in whom delivery is imminent.
authors.affiliation: Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 77555, USA.
authors.forename: Holger
authors.initials: H
authors.lastname: Maul
authors.forename: Gayle
authors.initials: G
authors.lastname: Olson
authors.forename: Cordula T
authors.initials: CT
authors.lastname: Fittkow
authors.forename: George R
authors.initials: GR
authors.lastname: Saade
authors.forename: Robert E
authors.initials: RE
authors.lastname: Garfield
mesh_terms: D002584:Cervix Uteri / Q000502:physiology* / Q000528:radiation effects*; D036861:Delivery, Obstetric; D005260:Female; D005453:Fluorescence; D005544:Forecasting; D005865:Gestational Age; D006801:Humans; D008027:Light; D011247:Pregnancy; D012680:Sensitivity and Specificity; D013997:Time Factors