title: Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder.
abstract: Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Animesh
authors.initials: A
authors.lastname: Pardanani
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Kimlinger
authors.forename: Terra L
authors.initials: TL
authors.lastname: Reeder
authors.forename: Chin-Yang
authors.initials: CY
authors.lastname: Li
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000378:metabolism; D018801:CD2 Antigens / Q000378:metabolism*; D006402:Hematologic Diseases / Q000378:metabolism*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism*; D034721:Mastocytosis, Systemic / Q000378:metabolism*; D011446:Prospective Studies; D015375:Receptors, Interleukin-2 / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018801:CD2 Antigens; D015375:Receptors, Interleukin-2