title: Reduced expression of heterogeneous nuclear ribonucleoprotein B1 in adult T-cell lymphoma/leukemia.
abstract: It is considered that hnRNP B1 expresses similarly in the various types of tumor cells. Recently, we demonstrated high B1 expression in B-cell lymphoma and carcinoma. To evaluate the difference of B1 expression between B and T-cell lymphoma, we immunologically studied the B1 expression in 22 cases with nodal T-cell lymphoma, comprising adult T-cell leukemia/lymphoma (ATLL; n=15) and angioimmunoblastic T-cell lymphoma (AILD; n=7), using an anti-hnRNP B1 monoclonal antibody, 2B2. In ATLL cases, scattered large transformed lymphoma cells demonstrated strong B1 expression, while the medium-sized lymphoma cells were negative. On the one hand, lymphoma cells in AILD diffusely expressed B1. The mean B1 expression rate in ATLL was 22%, which was significantly lower than that in AILDs (45%), B-cell lymphomas (44%), and metastatic carcinomas (53%) (p<0.01). Our result might suggest that process of hnRNP B1 expression in ATLL differs from those in other lymphoid neoplasms and carcinoma.
authors.affiliation: Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tani
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Seiji
authors.initials: S
authors.lastname: Haraoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamma
authors.forename: Seiyo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D045744:Cell Line, Tumor / Q000737:chemistry; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D009363:Neoplasm Proteins; C439768:hnRNP A2