title: [Effects of nao-yi-an granule on the expression of heme oxygenase-1 in brains of intracerebral hemorrhagic rats].
abstract: OBJECTIVE
  To investigate the effects of the traditional Chinese medicine complex nao-yi-an granule(NYA) on the expression of heme oxygenase-1(HO-1) in the brains of intracerebral hemorrhagic (ICH) rats.
  
  
  METHODS
  After inducing ICH rat models with collagenase VII, we used the immunohistochemical method and HO-1 immunoreactive cell count to observe the HO-1 expression.
  
  
  RESULTS
  Following ICH, the expression of HO-1 in the rat brains was observed at 12 h, peaking at 2 d and persisting until 7 d; and NYA could increase the expression at 24 h obviously.
  
  
  CONCLUSIONS
  Expression of HO-1 increases following ICH,; upregulation of HO-1 expression may be one of the neuroprotective mechanisms of NYA.
authors.affiliation: Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tang
authors.forename: Tuan-lian
authors.initials: TL
authors.lastname: Luo
authors.forename: Xing-qun
authors.initials: XQ
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D051547:Heme Oxygenase-1; D020300:Intracranial Hemorrhages / Q000201:enzymology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1