[Clinical study on effect of yufeng capsule on premonitory symptoms of apoplexy].
OBJECTIVE
To observe the clinical effect of Yufeng Capsule (YFC), a Chinese herbal preparation with function of clearing Heat-toxin in treating premonitory symptoms of apoplexy in middle and old aged patients.


METHODS
One hundred and fourteen patients with premonitory symptoms of apoplexy were treated with YFC and compared with 57 patients treated with Venoruton for control. The changes of clinical symptoms, anti-oxidation capability, blood lipid, blood sugar and hemorrheological parameters were observed.


RESULTS
(1) The therapeutic effect in the YFC group was cured in 42 cases (36.84%), markedly effective in 38 (33.33%), effective in 28 (24.58%) and the total effective rate was 94.74%, while in the control group, the corresponding numbers were 9 (15.79%), 8(14.04%), 20(35.09%) and 64.91% respectively, the difference between the two groups in cure rate, markedly effective rate and total effective rate was significant (P < 0.05); (2) The whole blood viscosity, plasma viscosity, hemagglutination index and red blood cell deformity index in the YFC group were significantly improved after treatment (P < 0.01) and the improvement was better than those in the control group (P < 0.05 or P < 0.01); (3) Levels of serum malonyldialdehyde (MDA), superoxide dismutase (SOD), blood lipids and glucose were markedly improved in the YFC group (P < 0.05) after treatment, and showed a significant difference to those in the control group (P < 0.05).


CONCLUSIONS
YFC has obvious effect in treating premonitory symptoms of apoplexy patients, it could markedly improve the hemorrheologic parameters, regulate blood lipids and blood glucose metabolism, and strengthen the anti-oxidation capability of patients.
Zhao
Hai-bin
HB
Shandong University of TCM, Jinan 250014.
Shen
Cheng-ling
CL
Shao
Nian-fang
NF
D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D013482:Superoxide Dismutase / Q000097:blood*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase