Essential role for Vav1 in activation, but not development, of gammadelta T cells.
Vav1 is a guanine nucleotide exchange factor essential in the development and function of alphabeta lineage T cells. Here we report that in contrast to profound effects on pre-TCR- or alphabeta TCR-dependent events in thymocyte development, Vav1 deficiency has no detectable effect on the development of gammadelta T cells. Strikingly, however, these gammadelta T cells are markedly deficient in signaling through the gammadelta TCR, as evidenced by a lack of proliferation and cytokine production in response to stimulation with anti-gammadelta TCR antibodies. We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the gammadelta TCR in lymphocytes.
Swat
Wojciech
W
The Center for Blood Research, Department of Pediatrics, The Children's Hospital, Boston, MA 02115, USA.
Xavier
Ramnik
R
Mizoguchi
Atsushi
A
Mizoguchi
Emiko
E
Fredericks
Jessica
J
Fujikawa
Keiko
K
Bhan
Atul K
AK
Alt
Frederick W
FW
D000818:Animals; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D051567:Proto-Oncogene Proteins c-vav; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D016692:Receptors, Antigen, T-Cell, gamma-delta; C496619:Vav1 protein, mouse