title: Cardioprotective effects of extracts from Psidium guajava L and Limonium wrightii, Okinawan medicinal plants, against ischemia-reperfusion injury in perfused rat hearts.
abstract: The aim of this study was to determine whether the medicinal herbs growing in Okinawa and possessing a radical-scavenging activity would exert cardioprotective effects against ischemia-reperfusion injury using isolated perfused rat hearts. Effects of the aqueous extracts from Psidium guajava L. and Limonium wrightii at concentrations having an equipotent radical-scavenging activity on myocardial injury produced by global ischemia followed by reperfusion were tested and were further compared with those of quercetin and gallic acid, major antioxidative components of P. guajava L. and L. wrightii, respectively. Both extracts significantly attenuated ischemic contracture during ischemia and improved myocardial dysfunction after reperfusion. Decreases in high-energy phosphates and increases in malondialdehyde in the reperfused hearts were significantly lessened with both plant extracts. Quercetin and gallic acid also exerted similar beneficial effects. These results indicate that P. guajava L. and L. wrightii both have cardioprotective effects against myocardial ischemia-reperfusion injury in isolated rat hearts, primarily through their radical-scavenging actions.
authors.affiliation: Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashiro
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Noguchi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Kanako
authors.initials: K
authors.lastname: Miyagi
authors.forename: Junko
authors.initials: J
authors.lastname: Nakasone
authors.forename: Mayuko
authors.initials: M
authors.lastname: Sakanashi
authors.forename: Makoko
authors.initials: M
authors.lastname: Sakanashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kukita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Aniya
authors.forename: Matao
authors.initials: M
authors.lastname: Sakanashi
mesh_terms: D000818:Animals; D002374:Catalase / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005707:Gallic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007564:Japan; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D029606:Plumbaginaceae / Q000737:chemistry; D031647:Psidium / Q000737:chemistry; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000494:pharmacology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts; D005707:Gallic Acid; D011794:Quercetin; D002374:Catalase; D013482:Superoxide Dismutase