Synthesis of granulatimide positional analogues.
The Stille coupling reaction of the stannylindole 13 with the 5-iodoimidazole derivative 14 (or 27) in the presence of PdCl(2)(PPh(3))(2) gave the corresponding indole-imidazole coupling product 15 (or 28), thereby affording a synthetic approach to 10-methylgranulatimide (7), 15-methylgranulatimide (11), and 10, 15-dimethylgranulatimide (12), as well as 10-methylisogranulatimide B (5).
Yoshida
Takuji
T
Showa Pharmaceutical University, Tokyo, Japan.
Nishiyachi
Masakazu
M
Nakashima
Nobuyuki
N
Murase
Masayuki
M
Kotani
Eiichi
E
D000470:Alkaloids / Q000138:chemical synthesis* / Q000302:isolation & purification
D000470:Alkaloids; C433587:granulatimide