title: Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells.
abstract: Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.
authors.affiliation: INSERM U 435/GERM, Université de Rennes I, Campus de Beaulieu, 35042 Rennes, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Le Goffic
authors.forename: Thomas
authors.initials: T
authors.lastname: Mouchel
authors.forename: Annick
authors.initials: A
authors.lastname: Ruffault
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Patard
authors.forename: Bernard
authors.initials: B
authors.lastname: Jégou
authors.forename: Michel
authors.initials: M
authors.lastname: Samson
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000378:metabolism*; D002522:Chlorocebus aethiops; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007700:Kinetics; D007985:Leydig Cells; D008297:Male; D009109:Mumps virus / Q000472:pathogenicity*; D012254:Ribavirin / Q000494:pharmacology; D013739:Testosterone / Q000096:biosynthesis*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D013739:Testosterone; D012254:Ribavirin; D007371:Interferon-gamma