title: Distraction osteogenesis by Ilizarov and unilateral external fixators in a canine model.
abstract: We studied distraction osteogenesis in canine experimental model using two types of external fixators, Ilizarov (n=6) or AO unilateral (n=9) external fixator. Distraction started 1 week after surgery (2 x 0.5 mm/day) and lasted for 3 weeks. Specimens were harvested from weeks 7 through 12. The outcome was assessed by X-ray, histology, histomorphometry and microradiography. Bone regeneration as observed by X-rays was satisfactory and similar in both groups. Both endochondral ossification and intramembranous ossification were found simultaneously in both groups. In both groups, bone formation parameters were significantly higher in the area of consolidating bone. No differences in histomorphometric parameters existed between the groups. In the study period, the bone formation was enhanced and prevailed in the distraction area. This study demonstrated the utility of the canine experimental model for the study of distraction osteogenesis.
authors.affiliation: Clinical Institute of Laboratory Diagnosis, Clinical Hospital Center, Kispaticeva 12, 10 000, Zagreb, Croatia. rkusec@rudjer.irb.hr
authors.forename: V
authors.initials: V
authors.lastname: Kusec
authors.forename: M
authors.initials: M
authors.lastname: Jelic
authors.forename: F
authors.initials: F
authors.lastname: Borovecki
authors.forename: J
authors.initials: J
authors.lastname: Kos
authors.forename: S
authors.initials: S
authors.lastname: Vukicevic
authors.forename: K
authors.initials: K
authors.lastname: Korzinek
mesh_terms: D000818:Animals; D001707:Biopsy, Needle; D016723:Bone Remodeling / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D016267:External Fixators; D017102:Fracture Healing / Q000502:physiology; D018889:Ilizarov Technique; D007150:Immunohistochemistry; D019857:Osteogenesis, Distraction / Q000295:instrumentation* / Q000379:methods; D011859:Radiography; D012680:Sensitivity and Specificity; D013977:Tibia / Q000473:pathology*; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000601:surgery*