title: Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.
abstract: A total synthesis of (+)-phomactin A is described using a B-alkyl Suzuki macrocyclization to incorporate the isolated trisubstituted olefin. This macrocyclization was accomplished with the sensitive hydrated furan ring in place. (R)-(+)-pulegone was used to establish the highly substituted cyclohexene core of the molecule.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mohr
authors.forename: Randall L
authors.initials: RL
authors.lastname: Halcomb
mesh_terms: D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; C413206:phomactin A