Coordination of thiouridine monophosphates with selected metal ions.
Potentiometric and spectroscopic data obtained for the complexes of two thio-substituted uridine-monophosphates with Cu(2+), Ni(2+) and Cd(2+) ions have shown that both thionucleotide are more effective ligands than their nucleoside analogues. The basic binding site for all metal ions is the sulfur atom. The chelation by adjacent N(3) donor is also likely, although unfavorable four-membered chelate ring is formed.
Swiatek-Kozlowska
Jolanta
J
Department of Basic Medical Sciences, Wroclaw Medical University, Kochanowskiego 14, 51601 Wroclaw, Poland. jsk@basmed.am.wroc.pl
Brasuń
Justyna
J
Dobosz
Agnieszka
A
Sochacka
Elzbieta
E
Glowacka
Alicja
A
D001665:Binding Sites; D002104:Cadmium / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D013057:Spectrum Analysis; D013891:Thiouridine / Q000737:chemistry*; D014500:Uracil Nucleotides / Q000737:chemistry*
D008670:Metals; D014500:Uracil Nucleotides; D002104:Cadmium; D013891:Thiouridine; D003300:Copper; D009532:Nickel