title: [Long-term toxicity experiment with tea for descending lipid and declining fat].
abstract: OBJECTIVE
  To investigate the chronic toxicity of tea for descending lipid and declining fat (TDLDF).
  
  
  METHODS
  4 groups Sprague-Dawley rats had respectively been fed with distilled water and TDLDF in 7 g/kg (high dosage), 3.2 g/kg (middle dosage) and 1.5 g/kg(lower dosage) for 12 weeks, the latter were respectively equal to 100, 50 and 20 times clinical dosage. After ig 6, 12 weeks and 3 weeks after discontinuation, the behavior, appetite, excrement and urine, body weight, hematological and biochemical markers, coefficient of the main organs and pathohistological examination of the rats were investigated.
  
  
  RESULTS
  There were no significant differences of the above markers between each experimental group and the control group.
  
  
  CONCLUSIONS
  The clinical recommended dosage of TDLDF is safe.
authors.affiliation: Guangzhou Academy of TCM, 510130.
authors.forename: Jiangling
authors.initials: J
authors.lastname: Lü
authors.forename: Yihai
authors.initials: Y
authors.lastname: Zou
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Saixia
authors.initials: S
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Shaoling
authors.initials: S
authors.lastname: Tang
authors.forename: Huiyun
authors.initials: H
authors.lastname: Guan
authors.forename: Xiuyin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D000960:Hypolipidemic Agents / Q000633:toxicity*; D030017:Ilex / Q000737:chemistry*; D031659:Ligustrum / Q000737:chemistry; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents