[A marker of early stages of diabetic retinopathy].
A comparative estimate of the hormonal status and coagulatory activity was carried out in patients with diabetes mellitus at the functional and subclinical stages of diabetic retinopathy and in those without signs of diabetic retinopathy. In all patients, the blood level of hormones was elevated, while in patients with functional and subclinical stages of diabetic retinopathy, the changes in hormonal status were accompanied by increased local and systemic potentials, disturbed microcirculation, and decreased functional activity of the retina outer layers. The increased hormone level affected the hemostatic potentials and induced their elevation at a certain stage. The reliably increased local hemostatic potential was one of the first signs of pathological action of the increased hormone level, while the increase of systemic hemostatic potential was unreliable. The combination of elevated blood level of hormones and coagulatory activity of the tear fluid is a marker fore revealing the group of risk for development of diabetic retinopathy in patients with diabetes mellitus.
Gavrilova
N A
NA
Moscow State Medical-Stomatologic University, ul. Delegatskaya 20/1, Moscow, 103473 Russia.
Lanevskaia
N I
NI
Antsiferova
N G
NG
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001777:Blood Coagulation / Q000502:physiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D005123:Eye / Q000098:blood supply; D006490:Hemostatics; D006728:Hormones / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013666:Tears / Q000502:physiology
D015415:Biomarkers; D006490:Hemostatics; D006728:Hormones