title: Burkitt lymphoma following splenic marginal zone lymphoma. evidence for two independent B-cell clones.
abstract: We report the progression of splenic marginal zone lymphoma (SMZL) with circulating villous lymphocytes to Burkitt lymphoma with the presence of a t(8;14)(q24;q32) followed by a highly aggressive course. While the initial indolent lymphoma had an IgM lambda immunophenotype the Burkitt lymphoma was IgM kappa-positive. Immunoglobulin heavy chain gene (IGH) sequence analysis showed no identity between the two clones. We conclude that Burkitt lymphoma can occur in patients with SMZL, although not necessarily of identical clonal origin.
authors.affiliation: Division of Hematology and Hemostaseology, Department of Internal Medicine I, The University of Vienna School of Medicine, Vienna, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Heintel
authors.forename: Berthold
authors.initials: B
authors.lastname: Streubel
authors.forename: Natascha
authors.initials: N
authors.lastname: Welzel
authors.forename: Trang
authors.initials: T
authors.lastname: Le
authors.forename: Ilse
authors.initials: I
authors.lastname: Schwarzinger
authors.forename: Oskar A
authors.initials: OA
authors.lastname: Haas
authors.forename: Ingrid
authors.initials: I
authors.lastname: Simonitsch
authors.forename: Klaus
authors.initials: K
authors.lastname: Lechner
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jaeger
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D013160:Splenic Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics