[Variant Frequency of Erythrocyte Glycophorin A in Persons Accidentally Irradiated by (60)Co Source]
Glycophorin A (GPA) is one of the important molecular markers in studies of somatic cell mutations. To investigate the relationship between the gamma-irradiation and the frequency of GPA variation, the frequency of variant erythrocytes at the GPA locus was determined in peripheral blood of 3 subjects with accidental whole-body gamma-irradiation. The biological dose of individuals was 2.5, 2.9 and 1.9 Gy estimated by the chromosome aberration assay, respectively, and the frequency of GPA variation was 3.9, 4.3 and 4.1 times greater than that from normal controls, respectively. Our results suggest that the variant frequency of erythrocyte GPA was increased. On account of the GPA gene mutations are preserved in hematopoietic stem cells during all irradiated individual's life, the frequency of GPA variation could be used as a permanent marker for mutagenesis of radiation.
Dong
Yan
Y
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Mao
Jian-Ping
JP
Liu
Bin
B
Sun
Zhi-Xian
ZX