[CEA comprehensive evaluation for Western and traditional Chinese hypotensive drugs].
OBJECTIVE
To make a cost-effectiveness analysis (CEA) comprehensive evaluation for 4 hypotensive drugs, by observing the effects of drugs on blood pressure lowering, symptom improving, and adverse effect and quality of life (QOL) influencing.


METHODS
Two hundred and ninety-two patients with mild to moderate hypertension were divided into 4 groups at random and treated with compound Lingjiao Jiangya Pill, benazepril, amlodipine and indapamide respectively with a therapeutic course of 6 weeks. QOL was measured with FS-36 questionnaire and efficacy policy model was applied for comprehensive evaluation of CEA.


RESULTS
Through CEA a comprehensive evaluation was made in order as follows: indapamide 3.65 which was the best, and then Lingjiao Jiangya Pill 3.55, amlodipine 2.90 and benazepril 2.35.


CONCLUSIONS
The 4 drugs can not only lower blood pressure but also improve clinical symptoms with less adverse effect. It is of great practical significance to evaluate hypotensive drugs by combining QOL appraisal. The position of Lingjiao Jiangya Pill in CEA order suggests that more attention should be paid to herbal hypotensive drugs.
Wang
Y
Y
Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou 310003.
Li
L
L
He
B R
BR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000191:economics / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000191:economics / Q000627:therapeutic use*; D001552:Benzazepines / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D004365:Drugs, Chinese Herbal / Q000191:economics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000191:economics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000191:economics; D011788:Quality of Life
D000959:Antihypertensive Agents; D001552:Benzazepines; D004365:Drugs, Chinese Herbal; D017311:Amlodipine; D007190:Indapamide; C044946:benazepril