title: [Synthesis and antibacterial activities of 3,6-disubstituted-5,6-dihydrogen-1,2,4-s-triazolo-[3,4-b]-1,3,4-thiadiazoles].
abstract: OBJECTIVE
  To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings.
  
  
  RESULTS
  Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1, 2, 4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities.
  
  
  CONCLUSIONS
  The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.
authors.affiliation: Department of Chemistry, Nanjing University, Nanjing 210093, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Shi
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: H X
authors.initials: HX
authors.lastname: Shi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013830:Thiadiazoles; D014230:Triazoles