title: Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
abstract: A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
authors.affiliation: Bristol-Myers Squibb PRI, PO Box 400, Princeton, NJ 08543-4000, USA. scott.waterson@bms.com
authors.forename: Scott H
authors.initials: SH
authors.lastname: Watterson
authors.forename: Marianne
authors.initials: M
authors.lastname: Carlsen
authors.forename: T G Murali
authors.initials: TG
authors.lastname: Dhar
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Shen
authors.forename: William J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: Junqing
authors.initials: J
authors.lastname: Guo
authors.forename: Henry H
authors.initials: HH
authors.lastname: Gu
authors.forename: Derek
authors.initials: D
authors.lastname: Norris
authors.forename: John
authors.initials: J
authors.lastname: Chorba
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Daniel
authors.initials: D
authors.lastname: Cheney
authors.forename: Mark
authors.initials: M
authors.lastname: Witmer
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Fleener
authors.forename: Katherine
authors.initials: K
authors.lastname: Rouleau
authors.forename: Robert
authors.initials: R
authors.lastname: Townsend
authors.forename: Diane L
authors.initials: DL
authors.lastname: Hollenbaugh
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Iwanowicz
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D015363:Quinolones; D007168:IMP Dehydrogenase