The role of complement and natural antibody in intestinal ischemia-reperfusion injury.
Activation of the complement cascade is central to many types of injury. Ischemia-reperfusion is an important example of such an event. Using intestinal ischemia-reperfusion as a model, we have further elucidated the importance and mechanism of this activation. Of novel importance is the evidence that natural antibody is a trigger for these events via recognition of self-antigen. In this article, we review the role of natural antibody and complement in intestinal ischemia-reperfusion injury. It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury.
Austen
W G
WG
Department of Surgery and Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kobzik
L
L
Carroll
M C
MC
Hechtman
H B
HB
Moore
F D
FD
D000818:Animals; D003167:Complement Activation / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology* / Q000473:pathology; D007518:Isoantibodies / Q000378:metabolism / Q000502:physiology*; D015427:Reperfusion Injury / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D007075:Immunoglobulin M; D007518:Isoantibodies