title: Modest familial aggregation of eating disorders in restrictive anorexia nervosa with adolescent onset in a Romanian sample.
abstract: The study of the familial psychopathology in relatives of restrictive anorexia nervosa (AN) probands whose diagnosis was verified during a long-term follow-up was aimed at determining behavioural phenotypes with which AN could share the genetic liability. A total of 185 first degree relatives of 68 restrictive AN patients with adolescent onset followed up for 5 to 18 years and 198 first degree relatives of 68 normal women were investigated. DSM-III-R criteria were used. The lifetime rate of clinical AN was 1% and the rate of any eating disorders was 2% in female proband relatives versus 0 in control relatives. No case of bulimia nervosa (BN) was found in proband relatives. The heritability of AN was low (0.18) when only the full-blown AN was considered in relatives and modest (0.36) when also a case of subthreshold AN was added. There were significantly higher rates of anxiety disorders (14.6%) and unipolar major depression (8.3%) in female proband relatives and "schizo"-spectrum disorders (8.3%) and alcoholism (13.1%) in male proband relatives compared to relatives of controls. Restrictive AN might share partial liability with phenotypes expressing emotional restraint and anxiety. A sex effect of the heterotypically affected relative on the vulnerability for AN was suggested.
authors.affiliation: Psychiatric Genetics and Developmental Psychopathology Research Unit, The Alexandru Obregia Psychiatric Hospital, Sos. Berceni, 10, O P 8, R-75622 Bucharest, Romania. mserban@dnt.ro
authors.forename: Maria
authors.initials: M
authors.lastname: Grigoroiu-Serbanescu
authors.forename: Sanda
authors.initials: S
authors.lastname: Magureanu
authors.forename: Stefan
authors.initials: S
authors.lastname: Milea
authors.forename: Iuliana
authors.initials: I
authors.lastname: Dobrescu
authors.forename: Elvira
authors.initials: E
authors.lastname: Marinescu
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D015897:Comorbidity; D005190:Family / Q000523:psychology*; D001068:Feeding and Eating Disorders / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D010641:Phenotype; D011599:Psychopathology; D012383:Romania / Q000453:epidemiology