[Effect of total diterpene of Rabdosia macrocalyx on mice of normal and immunosuppression].
OBJECTIVE
The regulatory effects of total diterpene of Rabdosia macrocalyx (Dunn) Hara on immune function were studied.


METHODS
The experimental immunosuppressive mouse models were induced by injection of cyclophosphamide.


RESULTS
The index of thymus gland and spleen in normal and immunosuppressive mice were increased significantly. So were the level of hemolysin in serum when 50 mg/kg total diterpene were given. Delayed hypersensivity were also enhanced at the same condition. But there didn't show any change in carbon clearance test.


CONCLUSIONS
Total diterpene of Rabdosia macrocalyx (Dunn) Hara possesses obvious regulatory action on immune function in mice.
Wang
J
J
Anhui Institute of Medical Sciences, Hefei 230061.
Yang
J
J
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D037602:Isodon / Q000737:chemistry; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology
D000276:Adjuvants, Immunologic; D004224:Diterpenes; D003520:Cyclophosphamide