title: Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
abstract: OBJECTIVE
  To assess the interactions between nocturnal hypoglycemia and sleep in children with type 1 diabetes mellitus (DM).
  
  
  METHODS
  Children with DM (n = 15) and 15 matched control children underwent full night polysomnographic recordings. Blood glucose levels were measured in the diabetic children by means of the MiniMed Continuous Glucose Monitoring System. Six of the diabetic children were also studied by peripheral arterial tonometry (an indirect indicator of sympathetic responses).
  
  
  RESULTS
  Five children with DM (33%) had profound nocturnal hypoglycemia, which was associated with increased sleep efficiency, increased slow wave sleep, and increased Delta power in spectral analysis of the electroencephalogram. Hypoglycemic episodes were not associated with sympathetic activation. Rapid decline in glucose levels (>25 mg/dL/hour) but not the absolute degree of hypoglycemia were associated with awakenings from sleep.
  
  
  CONCLUSIONS
  We conclude that sleep may inhibit sympathetic and arousal response to hypoglycemia. Rapid changes in glucose levels, independent of absolute glucose levels, may result in awakening from sleep. Continuous measurement of glucose levels during sleep may add important features in the treatment of children with DM.
authors.affiliation: Pediatrics Department A, Rambam Medical Center, and Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Giora
authors.initials: G
authors.lastname: Pillar
authors.forename: Guy
authors.initials: G
authors.lastname: Schuscheim
authors.forename: Ram
authors.initials: R
authors.lastname: Weiss
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
authors.forename: Karen C
authors.initials: KC
authors.lastname: McCowen
authors.forename: Arie
authors.initials: A
authors.lastname: Shlitner
authors.forename: Nir
authors.initials: N
authors.lastname: Peled
authors.forename: Naim
authors.initials: N
authors.lastname: Shehadeh
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D017286:Polysomnography; D012307:Risk Factors; D012720:Severity of Illness Index; D012894:Sleep Stages; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014851:Wakefulness
chemical_list: D001786:Blood Glucose