title: Paecilomyces variotii central nervous system infection in a patient with cancer.
abstract: Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through beta-tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5-fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.
authors.affiliation: Department of Microbiology and Clinical Microbiology, Istanbul University, Istanbul, Turkey. s.kantarcioglu@superonline.com
authors.forename: A S
authors.initials: AS
authors.lastname: Kantarcioğlu
authors.forename: G
authors.initials: G
authors.lastname: Hatemi
authors.forename: A
authors.initials: A
authors.lastname: Yücel
authors.forename: G S
authors.initials: GS
authors.lastname: De Hoog
authors.forename: N M
authors.initials: NM
authors.lastname: Mandel
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications*; D002494:Central Nervous System Infections / Q000188:drug therapy / Q000209:etiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology*; D009894:Opportunistic Infections; D010143:Paecilomyces / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles