title: Reduced cerebrovascular blood flow velocities and vasoreactivity in open-angle glaucoma.
abstract: OBJECTIVE
  To compare cerebral blood flow velocities between open-angle glaucoma (OAG) patients and controls, at baseline and during hyperoxia.
  
  
  METHODS
  Observational cohort study.
  
  
  METHODS
  A prospective study was conducted in a single institution. Sixteen OAG patients and 15 normal subjects, matched for age, were enrolled. Patients and controls were studied at baseline, while breathing room air, and during 100% oxygen breathing. The eye with the more severe visual field defect was chosen in glaucoma patients, while in controls, the study eye was chosen randomly. Subjects with history of diabetes, cardiovascular, or respiratory disease were excluded. Measurements included brachial arterial pressure, heart rate, intraocular pressure and transcranial Doppler (TCD). Mean and peak velocity and pulsatility index of the ipsilateral middle cerebral artery (MCA) were measured by TCD.
  
  
  RESULTS
  At baseline, MCA mean and peak systolic blood flow velocities were significantly lower in glaucoma patients compared with controls velocities were significantly lower in glaucoma patients compared with controls (mean velocity: 50.2 vs 65.3 cm/s, P <.05; peak velocity: 74.2 vs 96.8 cm/s, P <.05). Additionally, while hyperoxia significantly decreased both mean and peak systolic velocities in MCA of controls (mean velocity: 65.3 vs 57.7 cm/s, P <.05; peak velocity 96.8 vs 87.9 cm/s, P <.05), it did not cause any significant change in OAG patients.
  
  
  CONCLUSIONS
  Glaucoma patients were found to have lower MCA blood flow velocities and an absence of vasoreactivity to hyperoxia, compared with controls. The relationship of these cerebral hemodynamic abnormalities to glaucoma pathogenesis and progression remains to be explored.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA. alharris@indiana.edu
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.forename: Drora
authors.initials: D
authors.lastname: Zarfati
authors.forename: Miriam
authors.initials: M
authors.lastname: Zalish
authors.forename: Jose
authors.initials: J
authors.lastname: Biller
authors.forename: Clinton W
authors.initials: CW
authors.lastname: Sheets
authors.forename: Ehud
authors.initials: E
authors.lastname: Rechtman
authors.forename: Renata
authors.initials: R
authors.lastname: Migliardi
authors.forename: Hana J
authors.initials: HJ
authors.lastname: Garzozi
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D015331:Cohort Studies; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D007429:Intraocular Pressure; D008875:Middle Aged; D011446:Prospective Studies; D011673:Pulsatile Flow; D017585:Ultrasonography, Doppler, Transcranial; D014786:Vision Disorders / Q000503:physiopathology; D014794:Visual Fields