Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-alpha in a patient with chronic myelogenous leukemia.
We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-alpha (IFN-alpha) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-alpha treatment.
Hishida
Asahi
A
First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yamamoto
Kazuhito
K
Kato
Chiaki
C
Yokozawa
Toshiya
T
Emi
Nobuhiko
N
Tanimoto
Mitsune
M
Saito
Hidehiko
H
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D016898:Interferon-alpha / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D010677:Philadelphia Chromosome
D007166:Immunosuppressive Agents; D016898:Interferon-alpha; D016179:Granulocyte Colony-Stimulating Factor