[In vitro uranyle affinity of per (3,6-anhydro-2-O-carboxyméthyle)-alpha-cyclodextrin and conditions required for in vivo application].
Per (3.6-anhydro-2-O-carboxymethyle)- alpha-cyclodextrin ([1]) is a polydentate analog of EDTA, a well-known cation chelating reagent. [1] exhibits strong affinities in vitro for lanthanids, cobalt and also for uranyl cations. Hence, a 1:1 stoechiometry and a high affinity for uranyle (6<logK<7) is found in vitro. Moreover, [1] is not hemolytic and exhibits not lettral properties in mice (LD(50)=42mM). In vivo injection at supralethal amounts of uranyl complex of [1] prevents immediate death in mice while unable to protect against later death. Pharmacocinetic studies show that a dissociation of the complex occurs lead to the release of free uranyle. Other complexation assays using [1] grafted tissues show that chelating properties for lead and uranyle differ from thoses observed in vitro.
Debouzy
J C
JC
CRSSA/BCM, La Tronche.
Gadelle
A
A
Tymen
H
H
Le Gall
B
B
Millot
X
X
Moretto
P
P
Fauvelle
F
F
Le Peoc'H
M
M
Dabouis
V
V
Martel
B
B
D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003505:Cyclodextrins / Q000737:chemistry*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D017974:Uranium Compounds / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics / Q000633:toxicity*; D047391:alpha-Cyclodextrins
C472889:(3,6-anhydro-2-O-carboxymethyle)-cyclodextrin; D002614:Chelating Agents; D003505:Cyclodextrins; D017974:Uranium Compounds; D047391:alpha-Cyclodextrins