Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.
Contact allergy to p-tert-butylphenol-formaldehyde resin is not rare. This resin consists of a large number of substances, most of which are unknown. For diagnostic and preventive reasons, the chemical identity of the sensitizers should be known as well as their sensitizing capacities, cross-reaction patterns and presence in the environment. The aim of this study was to investigate the sensitizing capacities and cross-reaction patterns for 5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzaldehyde and 5-tert-butyl-2-hydroxy-benzaldehyde in the guinea pig maximization test. 2,6-Dimethylol p-tert-butylphenol, p-tert-butylcate chol, 2-methylol p-tert-butylphenol, p-tert-butylphenol, 4-tert-butyl-2-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyloxymethyl)-6-hydroxymethyl-phenol and 4-tert-butyl-2-(5-tert-butyl-2-hydroxy-benzyloxymethyl)-phenol were used as potential cross-reacting substances. 5-tert-Butyl-2-hydroxy-3-hydroxymethyl-benzaldehyde was shown to be a sensitizer (p = 0.041). In animals induced with this compound no cross-reactions to the putative cross-reacting substances were seen. In contrast, 5-tert-butyl-2-hydroxy-benzaldehyde failed to induce sensitization and no cross-reactions were detected.
Zimerson
Erik
E
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden. erik.zimerson@derm.mas.lu.se
Bruze
Magnus
M
D000485:Allergens / Q000009:adverse effects*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007428:Intradermal Tests / Q000379:methods; D023421:Models, Animal; D012117:Resins, Synthetic / Q000009:adverse effects*
D000485:Allergens; D012117:Resins, Synthetic; C014273:p-tert-butylphenolformaldehyde resin