Theoretical analysis of mixed irradiation.
We revised the models for mixed irradiation by Zaider and Rossi and by Suzuki, substituting second-order repair function for a first-order one in reduction and interaction factors of the models. The reduction factor, which reduces the contribution of the square of a dose to cell killing in the models, and the interaction factor, which also reduces the contribution of the interaction of two or more doses of different types of radiation, were formulated by using the second-order repair function. These newly modified models for mixed irradiation can express or predict cell survival more accurately than the older ones, especially when irradiation is prolonged at low dose rates.
Suzuki
S
S
Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Miura
Y
Y
D002470:Cell Survival / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair; D008962:Models, Theoretical; D011829:Radiation Dosage; D011853:Radiobiology