A new cell therapy using bone marrow cells to repair damaged liver.
Hepatic stem cells can transdifferentiate into hepatocytes, bile duct cells, pancreatic cells, or intestinal cells. Hepatic stem cells had been thought to be located in the canal of Hering in the liver, but recent work has demonstrated the existence of hepatic stem cells in bone marrow as well. Cell therapy using autologous bone marrow cells has few ethical problems and many applications for treating severe liver disease. Further in vitro and in vivo analysis is crucial to develop the therapy for clinical use.
Terai
Shuji
S
Department of Molecular Science and Applied Medicine (Gastroenterology and Hepatology), Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.
Yamamoto
Naoki
N
Omori
Kaoru
K
Sakaida
Isao
I
Okita
Kiwamu
K
D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D022781:Hepatocytes; D008107:Liver Diseases / Q000473:pathology / Q000628:therapy*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D051381:Rats; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome