[Hypoglycemic effect of saponin from Tribulus terrestris].
OBJECTIVE
To study the hypoglycemic effect of saponin from Tribulus terrestris L.


METHODS
Alloxan was used to establish the diabetic model in mice. Phenformin Hydrochlride Tables was used as the positive control. The level of glucose, triglyceride, cholesterol and SOD in serum were determined.


RESULTS
The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% and 40.67% in normal mice and diabetic mice in respectively. The level of serum triglyceride could be reduced 23.35%. The saporin could also decrease the content of serum cholesterol. Serum SOD activity of the mice was increased by the saponin.


CONCLUSIONS
Saponin from Tribulue terrestris could significantly reduce the level of serum glucose.
Li
Mingjuan
M
School of Life Science, East China Normal University, Shanghai 200062.
Qu
Weijing
W
Wang
Yifei
Y
Wan
Hong
H
Tian
Cuiping
C
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D032444:Tribulus / Q000737:chemistry*
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D012503:Saponins