title: [Case report: rheumatoid arthritis and large granular lymphocytes syndrome].
abstract: Felty's syndrome (FS) is a rare complication (less than 1%) of rheumatoid arthritis (RA), with the clinical feature of splenomegaly and neutropenia. Approximately 10-40% of FS patients have an expansion of peripheral blood large granular lymphocytes (LGL). This cell population mainly consists of two subsets: cytotoxic T cells (CD8+, CD57+) and natural killer cells (CD3-,CD8-,CD56+). It has been hypothesised that LGL expansion could be responsible for neutropenia by suppressing neutrophil precursors in the bone marrow, but various mechanisms have been proposed to explain this association. We report a case of a 60-year-old woman with rheumatoid factor positive RA who developed LGL expansion responsible for splenomegaly, but without neutropenia. In conclusion, LGL expansion is an uncommon complication of RA and may be responsible for both FS and clinical pictures resembling FS.
authors.affiliation: Istituto Ortopedico Gaetano Pini, Milano, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Ingegnoli
authors.forename: M
authors.initials: M
authors.lastname: Arreghini
authors.forename: B
authors.initials: B
authors.lastname: Panni
authors.forename: R
authors.initials: R
authors.lastname: Capra
authors.forename: F
authors.initials: F
authors.lastname: Galbiati
authors.forename: P
authors.initials: P
authors.lastname: Bonara
authors.forename: A
authors.initials: A
authors.lastname: Marchesoni
mesh_terms: D005258:Felty Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008875:Middle Aged