title: Membrane introduction mass spectrometry for monitoring complexation equilibria of beta-cyclodextrin with substituted benzenes.
abstract: Membrane introduction mass spectrometry (MIMS) was used to monitor complexation reactions between beta-cyclodextrin (CD) and a series of benzene derivatives in aqueous solution. The equilibrium constants for benzene, chlorobenzene, bromobenzene, iodobenzene, toluene, cyanobenzene and nitrobenzene were determined. The suitability of MIMS for monitoring complexation reactions of organic compounds with host molecules was demonstrated. Structure-activity relationship analysis shows that the inclusion phenomena are driven by a variety of chemical forces, of which hydrophobicity is predominant for non-polar compounds, but not the only factor for more polar ones.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN 47907-1393, USA. augusti@dedalus.lcc.ufmg.br
authors.forename: Rodinei
authors.initials: R
authors.lastname: Augusti
authors.forename: Maciej
authors.initials: M
authors.lastname: Turowski
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks