[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors].
The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human alpha and B estrogen receptors was achieved.
Kirkiacharian
S
S
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, 5 rue Jean-Baptiste Clément, F92296-Chatenay Malabry Cedex.
Lormier
A T
AT
Resche-Rigon
M
M
Bouchoux
F
F
Cérède
E
E
D002478:Cells, Cultured; D003374:Coumarins / Q000138:chemical synthesis* / Q000378:metabolism; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D006801:Humans; D007202:Indicators and Reagents; D011960:Receptors, Estrogen / Q000378:metabolism*
D003374:Coumarins; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D007202:Indicators and Reagents; D011960:Receptors, Estrogen