title: Day- and night-time blood pressure elevation in children with higher grades of renal scarring.
abstract: OBJECTIVE
  We used 24-hour ambulatory blood pressure measurement (ABPM) to screen for early changes in children with renal scarring compared with healthy controls, and we investigated correlations between the extent of renal damage and blood pressure (BP). Study design Untreated patients (n = 61) with renal scars associated with recurrent urinary tract infection and vesico-ureteric reflux were investigated and compared with 904 healthy controls.
  
  
  RESULTS
  A significant positive correlation between the extent of renal scarring and systolic and diastolic BP standard deviation score (SDS) was found by using ABPM. Mean systolic day-time BP SDS in ABPM was significantly elevated in girls with renal scars compared with healthy controls, but failed to be significant in boys. Mean systolic and diastolic night-time BP SDS were significantly elevated in patients. Compatible with these results, diastolic dipping was significantly lower in patients compared with controls.
  
  
  CONCLUSIONS
  The increase in BP obtained by ABPM is positively correlated with the degree of scarring in our group of patients. Elevated night-time BP might be the most sensitive indicator of BP elevation in these children.
authors.affiliation: Departments of Pediatrics and Nuclear Medicine, Friedrich-Schiller-University, Jena, Germany. ludwig.patzer@med.uni-jena.de
authors.forename: Ludwig
authors.initials: L
authors.lastname: Patzer
authors.forename: Tomas
authors.initials: T
authors.lastname: Seeman
authors.forename: Carmen
authors.initials: C
authors.lastname: Luck
authors.forename: Elke
authors.initials: E
authors.lastname: Wühl
authors.forename: Jan
authors.initials: J
authors.lastname: Janda
authors.forename: Joachim
authors.initials: J
authors.lastname: Misselwitz
mesh_terms: D000367:Age Factors; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods / Q000592:standards; D016022:Case-Control Studies; D002648:Child; D002940:Circadian Rhythm; D003971:Diastole; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000209:etiology*; D007674:Kidney Diseases / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000592:standards; D015999:Multivariate Analysis; D019275:Radiopharmaceuticals; D012008:Recurrence; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013599:Systole; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000150:complications; D014718:Vesico-Ureteral Reflux / Q000150:complications
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid