title: Late complications of Candida (Torulopsis) glabrata fungemia: description of a phenomenon.
abstract: Complications occurring > 1 month after Candida glabrata fungemia have not been studied. We conducted a study to determine the frequency and morbidity of complications of C. glabrata bloodstream infections occurring > 1 month after infection. Late complications were common (incidence 9.9 per 100 patient years), and most often occurred within the first year. In a multivariate analysis, late complications were associated with the presence of diabetes mellitus [odds ratio (OR) 12.2; 95% confidence interval (CI) 1.2-130] and chronic renal failure (OR 14.7; 95% CI 1.2-184). These data suggest that careful long-term follow-up of patients with C. glabrata fungemia is important and present an opportunity to explore secondary prophylaxis.
authors.affiliation: Department of Infectious Diseases, The Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Tawanda
authors.initials: T
authors.lastname: Gumbo
authors.forename: Roy F
authors.initials: RF
authors.lastname: Chemaly
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Isada
authors.forename: Gerri S
authors.initials: GS
authors.lastname: Hall
authors.forename: Steven M
authors.initials: SM
authors.lastname: Gordon
mesh_terms: D000328:Adult; D041221:Candida glabrata / Q000472:pathogenicity / Q000502:physiology*; D002177:Candidiasis / Q000150:complications* / Q000401:mortality; D048909:Diabetes Complications; D005260:Female; D016469:Fungemia / Q000150:complications* / Q000401:mortality; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000401:mortality; D008297:Male; D016017:Odds Ratio; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors