[Functional and morphological observation on cells in allergic rhinitis guinea-pigs with cold or heat syndrome].
OBJECTIVE
To investigate the functional and morphological characteristics of cells in allergic rhinitis (AR) guinea-pigs with Cold or Heat Syndrome.


METHODS
The Cold Syndrome or Heat Syndrome guinea-pig model was made, and then reformed into AR model or rhinitis medicamentosa (RM) model by using nose drops of 10% toluene di-isocyanate (TDI) or 0.1% naphazoline hydrochloride. The cell function, count and ultramicroscopic morphology characteristics in the model animals were observed.


RESULTS
The degranulation index (DI), of blood basophils and the count of mast cells (MC) in nasal mucosa were higher in AR guinea-pigs with Cold Syndrome than that in Heat Syndrome guinea-pigs, but the two parameters in AR with both Cold and Heat Syndrome were higher than those in the RM model. Mast cell and eosinophilic granulocyte in AR guinea-pigs with Cold Syndrome were high in count, widely infiltrated, indiscernible cellular capsule, heterogeneous in density, and vacuoles, fusions and tubules in granules while in those with Heat Syndrome, mast cells and eosinophils were scarcely found, without infiltration, granules with discernible membrane and homogeneous in density, no vacuoles, fusions and tubules in granules.


CONCLUSIONS
The basophilic cells, mast cells and eosinophilic granulocytes in AR guinea-pigs with Cold Syndrome are in activated condition.
Zhou
X J
XJ
Department of ENT, Liuzhou Municipal Hospital of TCM, Guangxi 545001.
An
H
H
Tian
D F
DF
D000818:Animals; D001491:Basophils / Q000502:physiology; D015550:Cell Degranulation; D003937:Diagnosis, Differential; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008516:Medicine, Chinese Traditional; D009297:Nasal Mucosa / Q000473:pathology*; D011897:Random Allocation; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology* / Q000503:physiopathology; D013577:Syndrome