[Synthesis of 4-, 6- or 7-substituted phenyliminomethylenecoumarins and their anticancer activities].
OBJECTIVE
A series of substituted phenyliminomethylenecoumarins derivatives was designed in order to find compounds possessing anticancer activities.


METHODS
Title compounds (1a-b, 2a-b and 3a-q) were synthesized and screened by several anticancer models in vitro.


RESULTS
Twenty-one new compounds (1a-b, 2a-b and 3a-q) were synthesized and screened. Structures of the new compunds were determined by MS, HNMR and elemental analysis. Twelve compounds (3c, 3d, 3e, 3f, 3g, 3h, 3j, 3k, 3m, 3o, 3p, 3q) showed inhibitory effects on HCT-8, KB and Bel7402 cell lines in vitro.


CONCLUSIONS
Some compounds had certain anticancer activities and were worth further studying.
Xu
Song
S
Institute of Materia Medica, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100050, China.
Xu
Shi-ping
SP
Li
Lan-min
LM
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007624:KB Cells / Q000187:drug effects; D008113:Liver Neoplasms / Q000473:pathology; D015394:Molecular Structure; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D003374:Coumarins; D007097:Imines