C-reactive protein is an independent predictor of mortality in women with HIV-1 infection.
The relationship of C-reactive protein (CRP) to mortality was assessed in 209 HIV-1-infected women after adjusting for age, body mass index (BMI), serum albumin, CD4 cell lymphocyte count, and HIV-1 RNA. During the follow-up period of up to 5 years (median = 45 months) there were 49 deaths. CRP at study enrollment was measured using a low sensitivity assay. CRP levels were only weakly correlated (Pearson correlation coefficient r < .2) with other predictors of mortality. CRP was a powerful predictor of mortality (p < .01) after adjusting for age, BMI, serum albumin, CD4 cell lymphocytes, and HIV-1 RNA. The relative hazard associated with an elevated CRP level, independent of the covariates noted above, varied from 3.4- to 13.6-fold depending on how CRP values were grouped. CRP may be a useful and inexpensive predictor of HIV disease mortality in women.
Feldman
Joseph G
JG
Department of Preventive Medicine & Community Health, SUNY, Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Joseph.Feldman@Downstate.edu
Goldwasser
Philip
P
Holman
Susan
S
DeHovitz
Jack
J
Minkoff
Howard
H
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000401:mortality; D015497:HIV-1; D006801:Humans; D009519:New York City / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis
D015415:Biomarkers; D002097:C-Reactive Protein