Current studies on oxidant stress in dialysis.
Breath ethane measurements in hemodialysis indicate that a portion of these patients suffer increased oxidant stress, consistent with findings using other methods for oxidant stress determination. Loosely-bound iron definitely appears in the bloodstream when substantial doses of IV iron are administered, since transferrin is fully saturated, but our investigations generally do not show short-term oxidant stress from this treatment. If small doses of IV iron are utilized, transferrin saturation can be avoided, and risk is minimized. The vitamin C status of hemodialysis patients is usually lower than the general population, and the impact of this deficiency must be assessed in controlled investigations. Various interventions, including the vitamin E-bonded dialyzer and dietary antioxidant supplements, may ameliorate a portion of the oxidant stress in hemodialysis patients.
Handelman
Garry J
GJ
Health and Clinical Science, University of Massachusetts, Lowell 01854, USA. garry_handelman@uml.edu
D001206:Ascorbic Acid Deficiency / Q000209:etiology; D001944:Breath Tests; D020099:Coated Materials, Biocompatible; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation; D014810:Vitamin E
D020099:Coated Materials, Biocompatible; D014810:Vitamin E; D007501:Iron