Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder.
We previously observed in four autistic patients a new allele (GXAlu 5) of the GXAlu microsatellite marker located in intron 27b of the neurofibromatosis type 1 (NF1) gene (17q11.2). This large intron contains the OMGP gene, coding for the oligodendrocyte myelin glycoprotein expressed by neurons and oligodendrocytes. In the present work, we analysed the distribution of a coding single nucleotide polymorphism (OMGP62) of the OMGP gene, the nearest gene to the GXAlu marker, in a control population (n=101) and in an autistic group (n=65). We observed no significant difference in allele distribution comparing these two groups (chi(2)=1.81; P=0.179). When distinguishing an autistic group with a developmental quotient (DQ) higher than 30 (n=37) and one with a DQ lower than 30 (n=28), we observed an association between allele A and the group with the highest DQ (P=0.015). We found no other polymorphism using SSCP screening and DNA sequencing in the OMGP coding region in 16 autistic patients bearing OMGP62 allele A.
Vourc'h
Patrick
P
Génétique de la Déficience Mentale et de l'Autisme, INSERM U 316, Faculté de Médecine, 2bis, Boulevard Tonnellé, 37032, Tours Cedex, France.
Martin
Isabelle
I
Marouillat
Sylviane
S
Adrien
Jean Louis
JL
Barthélémy
Catherine
C
Moraine
Claude
C
Müh
Jean Pierre
JP
Andres
Christian
C
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D058851:GPI-Linked Proteins; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000235:genetics*; D063308:Myelin-Oligodendrocyte Glycoprotein; D011110:Polymorphism, Genetic
D058851:GPI-Linked Proteins; C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; C560528:OMG protein, human