Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS.
Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).
Dell'Albani
P
P
Institute of Neurological Sciences, Section of Catania, National Research Council (CNR), v.le Regina Margherita 6, 95123-Catania, Italy. dealpa@mbox.unict.it
Santangelo
R
R
Torrisi
L
L
Nicoletti
V G
VG
Giuffrida Stella
A M
AM
D000818:Animals; D002490:Central Nervous System / Q000201:enzymology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D019001:Nitric Oxide Synthase / Q000235:genetics; D052247:Nitric Oxide Synthase Type II; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
D014157:Transcription Factors; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D011505:Protein-Tyrosine Kinases