Tris lipidation--a novel drug delivery system that alters biodistribution.
Tris-lipidation uses Tris to produce drug-fatty acyl conjugates. Radiolabelled Tris-fatty acyl conjugates of methotrexate (MTX) were examined in biodistribution studies in BALB/c mice. Following delivery via a variety of routes, the Tris-lipidated compounds demonstrated features in common with other colloid drug delivery systems. Tissues of the reticuloendothelial system localised the drug following intravenous administration, and the compounds showed prolongation at the site of injection into muscle or fatty tissue, subcutaneously or when inhaled. These findings indicate that the Tris-lipidation platform could be classed as an alternative colloid drug delivery system.
Walker
Catherine
C
CSIRO Molecular Science, Riverside Corporate Park, Delhi Rd, PO Box 184, North Ryde, NSW 1670, Australia.
Fraser
Julie M
JM
Walton
Clayton E
CE
Widmer
Fred
F
Francis
Craig L
CL
Yang
Qi
Q
O'Sullivan
Maree
M
Whittaker
Robert G
RG
Wells
Xanthe E
XE
D000818:Animals; D001682:Biological Availability; D003102:Colloids; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D008055:Lipids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D014325:Tromethamine / Q000008:administration & dosage* / Q000493:pharmacokinetics
D003102:Colloids; D008055:Lipids; D014325:Tromethamine