title: Sustained hypoxia promotes hyperactive response of carotid body in the cat.
abstract: Carotid body chemosensory activities were measured before and after 0.2, 5,6 and 7 h of sustained isocapnic (PaCO(2) approximately equal to 30 Torr) hypoxia (PaO(2) approximately equal to 43 Torr) in the cats (n=7). The activity increased from 5.4 impsec(-1) at 0.2 h to about 13 impsec(-1) at 7 h. This increase in chemosensory activities were due to both an augmented sensitivity and to a long-term facilitation and not due to arterial [H(+)] changes.
authors.affiliation: Department of Biomedical Sciences, School of Medicine, Chieti University, 66100 Chieti, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Di Giulio
authors.forename: W X
authors.initials: WX
authors.lastname: Huang
authors.forename: A
authors.initials: A
authors.lastname: Mokashi
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: M
authors.initials: M
authors.lastname: Cacchio
authors.forename: M A
authors.initials: MA
authors.lastname: Macrì
authors.forename: S
authors.initials: S
authors.lastname: Lahiri
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000378:metabolism*; D002415:Cats; D002628:Chemoreceptor Cells / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D008297:Male