title: Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli.
abstract: Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin epsilon. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin alpha enteropathogenic (EPEC) O127:H6.
authors.affiliation: Centre for Paediatric Gastroenterology, Lower 3rd Floor, Royal Free Hospital, Pond St, NW3 2QG, London, UK.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Fitzhenry
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
authors.forename: Claire
authors.initials: C
authors.lastname: Jenkins
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Wallis
authors.forename: Robert
authors.initials: R
authors.lastname: Heuschkel
authors.forename: Simon
authors.initials: S
authors.lastname: Murch
authors.forename: Michael
authors.initials: M
authors.lastname: Thomson
authors.forename: Gad
authors.initials: G
authors.lastname: Frankel
authors.forename: Alan D
authors.initials: AD
authors.lastname: Phillips
mesh_terms: D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000166:cytology / Q000382:microbiology* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D009154:Mutation; D009924:Organ Culture Techniques; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018523:Tropism
chemical_list: D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli