[A fluorimetric study of the interactions of hydrochloridum berberini with vinylpyrrolidone and beta-cyclodextrin].
The interactions of hydrochloridum berberini with 1-vinyl-2-pyrrolidone and beta-cyclodextrin in aqueous solution were studied by spectrofluorimetric method. The spectral changes were quantitatively investigated. Results showed that the complexation with beta-cyclodextrin resulted in an enhancement of the fluorescence of hydrochloridum berberini whereas 1-vinyl-2-pyrrolidone caused a quenching of the fluorescence. It had been supposed 1:1 complex formation. Specifically, formation constants and the thermodynamic parameters at different temperatures were calculated.
Wu
W
W
Guangdong College of Pharmacy, Guangzhou 510224.
D001599:Berberine / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004347:Drug Interactions; D011205:Povidone / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013816:Thermodynamics; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D001599:Berberine; D011205:Povidone; C031215:betadex