Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis.
Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC 50 : 1.33 +/- 0.05 microM) and schisandrol A (IC 50 : 1.34 +/- 0.05 microM) showed higher activity than gomisin E (IC 50 : 4.73 +/- 0.09 microM), schisandrin A (IC 50 : 7.23 +/- 0.21 microM), schisandrin C (IC 50 : 7.54 +/- 0.22 microM), benzoylisogomisin O (IC 50 : 11.06 +/- 1.02 microM) and schisandrol B (IC 50 : 16.37 +/- 1.00 microM).
Lee
Im Seon
IS
Lee
Hyeong-Kyu
HK
Dat
Nguyen Tien
NT
Lee
Mi Sun
MS
Kim
Jung Woo
JW
Na
Doe Sun
DS
Kim
Young Ho
YH
D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D019169:Jurkat Cells; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D032141:Schisandra / Q000737:chemistry*; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
D004268:DNA-Binding Proteins; D017705:Lignans; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors