The activity of beta-hexosaminidase (uHex) and gamma-glutamyl-transferase (uGGT) in urine as non-invasive markers of chronic alcohol abuse: I. Alcohol-dependent subjects.
It has been demonstrated that in alcohol-dependent men the uHex test is one of the most powerful discriminating tools, while uGGT has a discriminating power similar to that of sHex but worse than that of uHex, sGGT and s%CDT. Receiver Operating Characteristic (ROC) areas under the curves (AUC) for uHex, uGGT, s%CDT, sHex and sGGT were 0.92, 0.79, 0.88, 0.79 and 0.92, respectively. Due to their good parameters, low cost, ease of use and non-invasive character the uHex and uGGT tests are useful tools for the detection of chronic alcohol abuse.
Taracha
E
E
Department of Biochemistry, Institute of Psychiatry and Neurology, 1/9 Sobieskiego Str. 02-957 Warsaw, Poland. habratb@ipin.edu.pl
Habrat
B
B
Woźniak
P
P
Walkowiak
J
J
Szukalski
B
B
D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000201:enzymology* / Q000534:rehabilitation; D015415:Biomarkers; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism* / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000378:metabolism* / Q000652:urine
D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D001619:beta-N-Acetylhexosaminidases