Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsia.
The present study investigated plasma activity of 5'-nucleotidase, a key enzyme in the production of adenosine, in pre-eclampsia, and evaluated the relationship between changes in 5'-nucleotidase activity, and levels of uric acid, endproduct of the purine metabolism, and the severity of pre-eclampsia. We measured plasma 5'-nucleotidase activities and uric acid levels in women with 18 normal pregnancies, mild and severe pre-eclampsia. In mild and severe pre-eclampsia, plasma 5'-nucleotidase activities and uric acid levels were significantly increased compared with those in normal pregnancy (p < 0.05). Plasma 5'-nucleotidase activity increased according to increases in uric acid levels and the severity of pre-eclampsia. These results suggest that increased plasma 5'-nucleotidase activity may, at least in part, be related to changes in purine metabolism in pre-eclampsia.
Yoneyama
Yoshio
Y
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
Suzuki
Shunji
S
Sawa
Rintaro
R
Otsubo
Yasuo
Y
Miura
Atsushi
A
Kuwabara
Yoshimitsu
Y
Ishino
Hiroshi
H
Kiyokawa
Yasuko
Y
Doi
Daisuke
D
Yoneyama
Koichi
K
Kobayashi
Hajime
H
Araki
Tsutomu
T
D015720:5'-Nucleotidase / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D015720:5'-Nucleotidase