title: [Relation between insulin resistance and A1166C molecular variant of type 1 angiotensin II receptor gene in patients with coronary heart disease].
abstract: OBJECTIVE
  To explore the relation between insulin resistance(IR) and A1166C molecular variant of type 1 angiotensin II receptor(AT1R) gene in Chinese subjects with coronary heart disease(CHD).
  
  
  METHODS
  IR was calculated by 1/(fast plasma insulin x fast plasma glucose). The A1166C molecular variant of AT1R gene was determined by polymerase chain reaction and restriction endonuclease analysis methods in 90 patients with coronary heart disease and 80 healthy people.
  
  
  RESULTS
  The frequency of allele C of group CHD was significantly higher than that of control group. There was no significant difference of IR level among AT1R A1166C AA, AC, CC genotypes in patients with CHD(P > 0.05).
  
  
  CONCLUSIONS
  No significant association between A1166C molecular variant of AT1R gene and insulin resistance was found in Chinese with CHD.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Juelin
authors.initials: J
authors.lastname: Deng
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Houzhi
authors.initials: H
authors.lastname: Yu
authors.forename: Dejia
authors.initials: D
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin