title: [Paraneoplastic ataxia associated to anti CV2 antibodies].
abstract: BACKGROUND
  Anti CV2 antibodies are a type of paraneoplastic antibodies that interact with the cytoplasmatic antigens of a subpopulation of oligodendrocytes. They are usually associated with the presence of a small cell carcinoma. We report the case of a patient with an epidermoid carcinoma of the lung and paraneoplastic cerebellous ataxia associated with anti CV2 antibodies.
  
  
  METHODS
  Male aged 73, ex smoker for 10 years, with a 45 packet/year habit. He presented a 5 month old constitutional syndrome. Altered gait with a sensation of instability. During the course of the exploration, we detected an increase in the support base, the impossibility to walk in tandem, non exhaustible horizontal nystagmus in bilateral extreme look, and vertical when looking down, with abolition of Achilles reflexes. Brain MR revealed supratentorial demyelinating lesions of a probable ischemic origin. Anti CV 2 antibodies in serum positive (anti HU negative). Biopsy performed using bronchial brushing in the left upper lobe detected the presence of malign epithelial strain, not microcytic, cells, which are compatible with epidermoid carcinoma.
  
  
  CONCLUSIONS
  Anti CV2 antibodies have only been found in patients who have developed a neurological syndrome within the context of a neoplasia. The detection of these antibodies in serum is related with the presence of a concealed neoplasia
authors.affiliation: Unidad de Neurología, Hospital General de Elda, Elda (Alicante), España. vivimema@villana.infoville.net
authors.forename: V
authors.initials: V
authors.lastname: Medrano
authors.forename: A P
authors.initials: AP
authors.lastname: Sempere
authors.forename: E
authors.initials: E
authors.lastname: González
mesh_terms: D000368:Aged; D001259:Ataxia / Q000209:etiology / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology; D008297:Male; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology / Q000276:immunology*
chemical_list: D001323:Autoantibodies