title: Interaction of sertraline with Candida species selectively attenuates fungal virulence in vitro.
abstract: This study investigated whether the interaction between isolates of Candida albicans (n=7), Candida parapsilosis (n=3), Candida krusei (n=2), Candida dubliniensis (n=1) and sertraline, a typical selective serotonin reuptake inhibitor, alters candidal virulence. Sertraline treatment of Candida spp. significantly (P<0.05) affected hyphal elongation, phospholipase activity, production of secreted aspartyl proteinases and fungal viability. In addition, monocyte-derived macrophages (MDMs) treated with sertraline reduced inhibition of blastoconidia germination in comparison to MDMs alone. In conclusion, our findings suggest that the interaction between sertraline and Candida spp. may also diminish the virulence properties of this fungal pathogen in vivo.
authors.affiliation: Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Str. 3, 6020 Innsbruck, Austria. cornelia.lass-floerl@uibk.ac.at
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: Maximilian
authors.initials: M
authors.lastname: Ledochowski
authors.forename: Dietmar
authors.initials: D
authors.lastname: Fuchs
authors.forename: Cornelia
authors.initials: C
authors.lastname: Speth
authors.forename: Laco
authors.initials: L
authors.lastname: Kacani
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Dierich
authors.forename: Anita
authors.initials: A
authors.lastname: Fuchs
authors.forename: Reinhard
authors.initials: R
authors.lastname: Würzner
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity*; D002176:Candida albicans / Q000254:growth & development / Q000472:pathogenicity; D002478:Cells, Cultured; D006801:Humans; D008264:Macrophages / Q000737:chemistry / Q000382:microbiology*; D009000:Monocytes / Q000737:chemistry / Q000382:microbiology*; D010740:Phospholipases / Q000037:antagonists & inhibitors; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline / Q000494:pharmacology*; D014774:Virulence
chemical_list: D016282:Aspartic Acid Endopeptidases; D010740:Phospholipases; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline