Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear.
Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects.
Wang
Yuan
Y
Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215-2406, USA.
Gilmore
Thomas D
TD
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D060850:LIM-Homeodomain Proteins; D051419:Paxillin; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors; D014158:Transcription, Genetic
D003598:Cytoskeletal Proteins; D018398:Homeodomain Proteins; C085473:LHX1 protein, human; D060850:LIM-Homeodomain Proteins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D014157:Transcription Factors