[Effect of different animal skin on the transdermal speed constant of sinomenine].
OBJECTIVE
To study the effect of different animal skin on the transdermal speed constant of sinomenine.


METHODS
Improved franz-cell was used for the transdermal study, pH6.8 phosphate buffer was used as the receptor and HPLC method was used for the determination of sinomenine through different animal skin.


RESULTS
The transdermal speed constant of the skin of hareless mice was much close to which of person. The higuchi equation of sinomenine through skin of hareless mice stored under -20 degrees C for 0d, 3d and 7d were Q = 40.34t1/2 + 196, Q = 38.01t1/2 + 25.3, Q = 41.55t1/2 + 24.7 respectively.


CONCLUSIONS
The results indicate that skin of hareless mice is suitable for the transdermal study of sinomenine, and the effect of storing time (0-7d) under -40 degrees C is not obvious.
Li
R
R
Guangzhou University of TCM, 510407.
Zhou
L
L
Liu
Q
Q
D000279:Administration, Cutaneous; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D008819:Mice, Nude; D009019:Morphinans / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010539:Permeability; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013997:Time Factors; D014021:Tissue Preservation
D009019:Morphinans; C009271:sinomenine