title: [Preparation of tea polyphenols sustained-release microcapsule].
abstract: With ethycellulose (EC) as matrix tea polyphenols (TP) microcapsule was prepared by using emulsion solvent evaporation technique. Effect of preparation condition on size and drug entrapment efficiency of microcapsule was investigated. We also investigated the drug entrapment effect of microcapsule. The result showed that the tawny microcapsule with highly porous surface was obtained by using polyvinyl alcohol (PVA) and sodium dodccyl sulate (SDS) as dispersant. The stirring rate, polymer concentration and drug payload affected the size and drug entrapment efficiency of microcapsule. The matrix and preparation method do not damage the ingredient of TP. The microcapsule can improve the stability of TP and sustain TP released.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Cen
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Xu
mesh_terms: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005419:Flavonoids; D010636:Phenols / Q000008:administration & dosage* / Q000302:isolation & purification; D011108:Polymers / Q000008:administration & dosage* / Q000302:isolation & purification; D059808:Polyphenols; D011142:Polyvinyl Alcohol; D012967:Sodium Dodecyl Sulfate; D013662:Tea / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D012967:Sodium Dodecyl Sulfate; D011142:Polyvinyl Alcohol