[Effect of dipeptide vilon on emotional stress resistance in rats].
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article. It is shown that intraperitoneal vilon injection rises the resistance against emotional stress according to prognostic indexes open field behaviour. Vilon administration also inhibits hypertrophy of the adrenals, involution of the thymus, and elevates concentration of albumin in the blood plasma. The number of Fos-immunoreactive neurons in the paraventricular hypothalamus was lower after vilon administration especially in rats resistant against emotional stress.
Koplik
E V
EV
P. K. Anokhin Research Institute of Normal Physiology of the Russian Acad. Med. Sci., Moscow 103009, B. Nikitskaya, 6, Russia.
Meshcheriakov
A F
AF
Pertsov
S S
SS
Umriukhin
P E
PE
Sudakov
K V
KV
Khavinson
V Kh
VKh
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects* / Q000502:physiology; D017781:Genes, Immediate-Early; D016762:Genes, fos; D020022:Genetic Predisposition to Disease; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000032:analysis; D013154:Spleen / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000235:genetics* / Q000503:physiopathology
D004151:Dipeptides; D018696:Neuroprotective Agents; D012709:Serum Albumin; C415909:lysylglutamic acid