An experimental study on homoharringtonine liposome and glaucoma filtration surgery.
OBJECTIVE
To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sites.


METHODS
Posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked fashion.


RESULTS
Fourteen days after operation the IOP of experimental eyes reduced significantly (P < 0.01) as compared with the controlled eyes, and the number of remaining filtering blebs increased noticeably (P < 0.05). Pathohistological examination revealed that the number of fibroblasts per square micron in the filtering sites and the thickness of the scars in the center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were found.


CONCLUSIONS
This experiment suggest that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma filtering surgery, promote the formation of filtering blebs, and provide an experimental evidence for its clinical use in future.
Peng
D
D
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Yu
K
K
Zeng
S
S
Li
Y
Y
Lin
J
J
Wu
Y
Y
Zhou
W
W
D000818:Animals; D002921:Cicatrix / Q000473:pathology; D018463:Filtering Surgery; D005901:Glaucoma / Q000473:pathology / Q000601:surgery*; D006248:Harringtonines / Q000494:pharmacology*; D000077863:Homoharringtonine; D008081:Liposomes / Q000494:pharmacology*; D011184:Postoperative Period; D011817:Rabbits
D006248:Harringtonines; D008081:Liposomes; D000077863:Homoharringtonine