[Effect of yiqi bushen huoxue herbs in treating children asthma and on levels of nitric oxide, endothelin-1 and serum endothelial cells].
OBJECTIVE
To observe the therapeutic effect of Yiqi Bushen Huoxue herbs (YQBSHX, the Chinese herbs for supplementing Qi, replenishing Kidney and activating blood circulation) on children asthma in regard to its effect on the serum levels of nitric oxide (NO), endothelin-1 (ET-1) and circulating endothelial cells (CEC).


METHODS
Two hundred children with asthma were divided into two groups, the YQBSHX and the control group, and their serum levels of NO, ET-1 and CEC were detected in acute and remission stage respectively. Twenty cases in each group were followed-up for 1 year to observe the frequency of asthma attack and the changes in ET-1, NO and CEC levels.


RESULTS
Serum levels of ET-1, NO and CEC in patients of acute stage were obviously raised. After treatment, the above-mentioned criteria in the YQBSHX group were significantly lower than those in the control group (P < 0.01). And the frequency of attack in the YQBSHX group was markedly reduced.


CONCLUSIONS
YQBSHX herbs could reduce ET-1, NO and CEC levels in children asthma, lessen the frequency of attack, therefore, to elevate the cure rate of children asthma.
Kong
L F
LF
Jining Municipal First People's Hospital, Shandong 272011.
Guo
L H
LH
Zheng
X Y
XY
D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D009569:Nitric Oxide