Evaluation of antiherpesvirus-1 and genotoxic activities of Helichrysum italicum extract.
The antiherpes virus-1 and genotoxic activities of diethyl ether extract from flowering tops of Helichrysum italicum (Compositae) were investigated. The extract showed significant antiviral activity at concentrations ranging from 400 to 100 microg/ml. This activity was not due to cytotoxic effect of the extract since Vero cells exhibited altered morphology or growth characteristics indicative of cytotoxic effects at higher concentration (800 microg/ml). Moreover H. italicum extract showed no DNA-damaging activity at concentrations up to 2000 microg/disk.
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Dipartimento Farmaco-Biologico, Sezione Microbiologia, Facoltà di Farmacia, Università di Messina, Italy.
Cannatelli
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MA
Marino
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Picerno
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I
Pizzimenti
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FC
Scoglio
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ME
Spataro
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P
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D004249:DNA Damage; D004279:DNA, Viral / Q000378:metabolism; D035263:Flowering Tops / Q000737:chemistry; D036562:Helichrysum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics; D014709:Vero Cells
D000998:Antiviral Agents; D004279:DNA, Viral; D010936:Plant Extracts