title: Epidemiology of non-Hodgkin lymphomas and other haemolymphopoietic neoplasms in people with AIDS.
abstract: HIV-infected individuals have a high risk of developing non-Hodgkin lymphoma (NHL). In Europe, the prevalence of AIDS with a concurrent NHL diagnosis increased from 3.6% to 5.4% between 1994 and 2000. In population-based record linkages between cancer registries and AIDS registries in the USA, Italy, and Australia, the relative risks of NHL in people with AIDS ranged between 15 for low-grade and T-cell NHL and 400 for high-grade NHL. The corresponding relative risk of Hodgkin's disease was about 10, whereas the risks for multiple myeloma and leukaemias were in the range 2 to 5. Since the introduction of highly active antiretroviral therapy in the more developed countries (1996), most studies have suggested a decline in the incidence of some types of NHL, most notably the primary brain form. In studies from Africa, the risk of HIV-associated NHL is about ten times less than that in the more developed countries, but underascertainment and earlier death from other AIDS-related illnesses may explain the relative lack of HIV-associated lymphomas.
authors.affiliation: Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy. epidemiology@cro.it
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D001315:Australia / Q000453:epidemiology; D019049:Developed Countries / Q000706:statistics & numerical data; D003906:Developing Countries / Q000706:statistics & numerical data; D005060:Europe / Q000453:epidemiology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000821:virology*; D012306:Risk; D014481:United States / Q000453:epidemiology