title: The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients.
abstract: Electrooculography (EOG) recordings in 21 L-DOPA-naive patients suffering from Parkinson's disease (PD) were made before and after apomorphine subcutaneous administration (ASA). The effect of apomorphine on smooth pursuit eye movements (SPEM) was studied. Age-matched healthy subjects, who underwent SPEM recordings without the ASA procedure, were examined in order to compare baseline SPEM. EOG recordings were used to compare the patient group and the control group, and to compare the SPEM before and after ASA within the patient group. Significant differences in SPEM were found between both groups, as well as in the SPEM before and after ASA. The theory that SPEM is disturbed in early PD patients was confirmed. The dopaminergic control of horizontal SPEM is supposed.
authors.affiliation: 1st Department of Neurology, Masaryk University, St Anne Hospital, Pekarská 53, 656 91, Brno, Czech Republic. martin.bares@fnusa.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Bares
authors.forename: Milan
authors.initials: M
authors.lastname: Brázdil
authors.forename: Petr
authors.initials: P
authors.lastname: Kanovský
authors.forename: Pavel
authors.initials: P
authors.lastname: Jurák
authors.forename: Pavel
authors.initials: P
authors.lastname: Daniel
authors.forename: Miloslav
authors.initials: M
authors.lastname: Kukleta
authors.forename: Ivan
authors.initials: I
authors.lastname: Rektor
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001058:Apomorphine / Q000494:pharmacology*; D004585:Electrooculography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D011698:Pursuit, Smooth / Q000187:drug effects* / Q000502:physiology
chemical_list: D001058:Apomorphine