[Correlation of sex hormones in blood serum and estrogen-progesterone receptors concentration in patients with laryngeal cancer].
Particular feature of larynx cancer epidemiology is large difference in morbidity at man and woman. It can be explained not only by exogenic factors, but also by endogenic once, including hormones. There was estimated estradiol and progesterone value in blood serum. The examined group comprised 12 larynx cancer patients. It was used radioimmunological assay Spectria by Orion Diagnostica. At the same time the estrogen and progesterone hormone receptor concentration was estimated in the neoplastic tissue in 18 patients. In the control group, in 10 patients the concentration was examined in surrounding, macroscopically unchanged tissue. The concentration of receptors was estimated by immunoenzymatic assay ER-EIA and PgR-EIA by Abbott. The quality assessment was done both in cytoplasmatic and nuclear receptors. There was performed correlation between hormone value in blood and receptor concentration in larynx cancer tissue at 12 patients and in non-neoplastic tissue at 5 patients. There were many abnormal steroid hormones value in blood serum. We found positive correlation between estradiol and progesterone value in blood and concentration of their receptors in larynx cancer. There were observed anomalies of hormone-receptor system at larynx cancer patients.
Piatkowski
Karol
K
Katedra i Klinika Otolaryngologii AM w Poznaniu.
Kruk-Zagajewska
Aleksandra
A
Thielemann
Anna
A
Kopczyński
Zygmunt
Z
D000368:Aged; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000737:chemistry; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000097:blood / Q000378:metabolism*; D007830:Larynx / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011374:Progesterone / Q000097:blood*; D011960:Receptors, Estrogen / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D012737:Sex Factors
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol