A synthetic overview of new molecules with 5-HT1A binding affinities.
The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT(1A)binding affinities. Specifically we focused our attention in the synthesis of compounds structurally related to arylpiperazine, 2-aminotetralin, and benzopyran derivatives.
Pessoa-Mahana
Hernán
H
Departamento de Química Orgánica y Fisicoquímica. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile. Olivos 1007.Casilla 233. Santiago 1. Chile. hpessoa@ll.ciq.uchile.cl
Araya-Maturana
Ramiro
R
Saitz
Claudio B
CB
Pessoa-Mahana
David C
DC
D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
D000928:Antidepressive Agents; D001578:Benzopyrans; D008024:Ligands; D010879:Piperazines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D013764:Tetrahydronaphthalenes; C006561:2-aminotetralin