title: Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice.
abstract: This study aimed at measuring the influence of a low salt diet on the development of experimental atherosclerosis in moderately hyperlipidemic mice. Experiments were carried out on LDL receptor (LDLR) knockout (KO) mice, or apolipoprotein E (apoE) KO mice on a low sodium chloride diet (LSD) as compared with a normal salt diet (NSD). On LSD, the rise of the plasma concentrations of TG and nonesterified fatty acid (NEFA) was, respectively, 19% and 34% in LDLR KO mice, and 21% and 35% in apoE KO mice, and that of plasma cholesterol was limited to the LDLR KO group alone (15%). Probably due to the apoE KO severe hypercholesterolemia, the arterial inner-wall fat storage was not influenced by the diet salt content and was far more abundant in the apoE KO than in the LDLR KO mice. However, in the less severe hypercholesterolemia of the LDLR KO mice, lipid deposits on the LSD were greater than on the NSD. Arterial fat storage correlated with NEFA concentrations in the LDLR KO mice alone (n = 14, P = 0.0065). Thus, dietary sodium chloride restriction enhances aortic wall lipid storage in moderately hyperlipidemic mice.
authors.affiliation: Lipids Laboratory (LIM 10), University of São Paulo Medical School, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Catanozi
authors.forename: Jussara C
authors.initials: JC
authors.lastname: Rocha
authors.forename: Marisa
authors.initials: M
authors.lastname: Passarelli
authors.forename: Maria L
authors.initials: ML
authors.lastname: Guzzo
authors.forename: Cleiton
authors.initials: C
authors.lastname: Alves
authors.forename: Luzia N S
authors.initials: LN
authors.lastname: Furukawa
authors.forename: Valéria S
authors.initials: VS
authors.lastname: Nunes
authors.forename: Edna R
authors.initials: ER
authors.lastname: Nakandakare
authors.forename: Joel C
authors.initials: JC
authors.lastname: Heimann
authors.forename: Eder C R
authors.initials: EC
authors.lastname: Quintão
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D001161:Arteriosclerosis / Q000209:etiology; D005227:Fatty Acids / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D051379:Mice; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000172:deficiency* / Q000235:genetics; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D005227:Fatty Acids; D008055:Lipids; D011973:Receptors, LDL; D017673:Sodium Chloride, Dietary; D014280:Triglycerides