[Effect of folic acid and supplemented with vitamin A and vitamin E on depressing teratogenesis induced by cyclophosphamide].
The effect of folic acid and the combined effect of folic acid(FA) + vitamin A + vitamin E on the prevention of teratogenesis induced by cyclophosphamide during pregnancy were observed. The results showed that cyclophosphamide resulted a decreased weight and length of the fetuses, an increased rate of neural tube defects and a retardation of ossification centers. The neural tube defects rates in the groups with no any supplementation, supplemented with folic acid alone and supplemented with FA + vitamin A + vitamin E were 87.27%, 42.93% and 30.08% respectively(P < 0.01). The supplementation of FA or the combined supplementation resulted also in greater fetal weight and length, increased ossification of supraoccipital bone (P < 0.01). The study suggested that the combined effect of FA, vitamin A and vitamin E was superior to FA alone.
Ma
A
A
Institute of Human Nutrition, Qingdao Medical College, Qingdao University, Qingdao 266021, China.
Xu
H
H
Du
W
W
Liu
Y
Y
D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D008297:Male; D009436:Neural Tube Defects / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D014801:Vitamin A; D014810:Vitamin E; D003520:Cyclophosphamide; D005492:Folic Acid