title: [Stability of neurohumoral effects of losartan combined with metoprolol in chronic cardiac low output].
abstract: Combined therapy with lozartan and metoprolol in patients with chronic cardiac insufficiency has a consistent effect on the levels of epinephrine, angoitensin II, vasopressin, atrial naturiuretic factor, insulin, endothelline, thromboxane B2, guanosine monophosphate, 6-keto prostaglandin F1 alpha, and bradikinin. As to norepinephrine, there has been noted an inconsistent therapeutic effect. It is suggested that the time-related course of a long-term therapy might be associated with a formation of the aldosterone "escape" phenomenon.
authors.forename: L B
authors.initials: LB
authors.lastname: Ushkvarok
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D057911:Angiotensin Receptor Antagonists; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000378:metabolism; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D019808:Losartan / Q000008:administration & dosage / Q000627:therapeutic use*; D008790:Metoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000451:Mineralocorticoid Receptor Antagonists; D017981:Receptors, Neurotransmitter; D008790:Metoprolol; D019808:Losartan