[Internal pharmacokinetical study on genistein chitosan microsphere capsule].
OBJECTIVE
To compare the distribution of genistein chitosan microsphere capsule (M.C) in vivo in rats with that of genistein common capsule (C.C). To research slow-released target microsphere capsule.


METHODS
The study on pharmacokinetics of M.C and C.C were analyzed by HPLC and 3P97 software.


RESULTS
The concentration of M.C distributed among various organs decreased slower than those of C.C and were able to keep a certain concentration for a long time. Genistein common capsule mainly distributed in livers of rats, while genistein chitosan microsphere capsule distributed mainly in lungs and spleens of rats.


CONCLUSIONS
The chitosan microsphere capsule of genistein has better slow-release and has tendency to distribute in lungs and spleens.
Wu
Wanying
W
College of Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102.
Li
Yungu
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D002686:Chitin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D048271:Chitosan; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D019833:Genistein / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism; D051379:Mice; D008863:Microspheres; D013154:Spleen / Q000378:metabolism
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D002686:Chitin; D048271:Chitosan; D019833:Genistein