Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.
A series of monocyclic delta-lactams (piperazones) was prepared and analysed as inhibitors of porcine pancreatic elastase and human neutrophil elastase.
Seibel
Jürgen
J
The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, UK.
Brown
David
D
Amour
Augustin
A
Macdonald
Simon J
SJ
Oldham
Neil J
NJ
Schofield
Christopher J
CJ
D000818:Animals; D003500:Cyclization; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D007769:Lactams / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013552:Swine
D007202:Indicators and Reagents; D007769:Lactams; D015842:Serine Proteinase Inhibitors; D010196:Pancreatic Elastase