Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells.
Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.
Le Goffic
Ronan
R
INSERM U 435/GERM, Université de Rennes I, Campus de Beaulieu, 35042 Rennes, France.
Mouchel
Thomas
T
Ruffault
Annick
A
Patard
Jean-Jacques
JJ
Jégou
Bernard
B
Samson
Michel
M
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000378:metabolism*; D002522:Chlorocebus aethiops; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007700:Kinetics; D007985:Leydig Cells; D008297:Male; D009109:Mumps virus / Q000472:pathogenicity*; D012254:Ribavirin / Q000494:pharmacology; D013739:Testosterone / Q000096:biosynthesis*; D014709:Vero Cells
D000998:Antiviral Agents; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D013739:Testosterone; D012254:Ribavirin; D007371:Interferon-gamma