[Effect of aqueous extract of Lepidium apetalum on dog's left ventricular function].
Left ventricular myocardial contractility, function of pump-blood and coronary flow in dog were increased by i.v. aqueous extract of Lepidium apetalum (AELA) 0.2 ml/kg (containing crude medicinal herb 2 g/ml). The effects were similar to i.v. isoperaline 10 micrograms/kg, but AELA did not obviously change heart rate, arterioveno-oxygen partial pressure difference and arteriovenooxygen solubility. The results indicated the AELA had advantages of cordial effect and increasing coronary flow instead of enhancing oxygen consumption of cardiac muscle.
Wu
X
X
Nanhai Hospital of TCM, Nanhai 528200.
Yang
Y
Y
Huang
D
D
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007545:Isoproterenol / Q000302:isolation & purification / Q000494:pharmacology; D029686:Lepidium / Q000737:chemistry*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012639:Seeds / Q000737:chemistry; D016277:Ventricular Function, Left / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D007545:Isoproterenol