title: Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear.
abstract: Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects.
authors.affiliation: Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215-2406, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Gilmore
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D060850:LIM-Homeodomain Proteins; D051419:Paxillin; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D003598:Cytoskeletal Proteins; D018398:Homeodomain Proteins; C085473:LHX1 protein, human; D060850:LIM-Homeodomain Proteins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D014157:Transcription Factors