title: Optimization of protein therapeutics by directed evolution.
abstract: Directed evolution is a broadly applicable technology platform that is ideally suited to address the need for protein optimization and to fully exploit the therapeutic potential of biologics. The approach takes advantage of the remarkable structural and functional plasticity of proteins and permits the rapid remodeling of biologics into new entities with improved functions. The ability to ameliorate virtually any characteristic of a protein can translate into significant clinical benefits, including decreased immunogenicity, higher potency, greater efficacy and improved safety profile, and can considerably increase the probability of successfully developing and commercializing biotherapeutics.
authors.affiliation: Applied Molecular Evolution (AME), 3520 Dunhill Street 92121, San Diego, CA, USA. avasserot@amevolution.com
authors.forename: Alain P
authors.initials: AP
authors.lastname: Vasserot
authors.forename: Craig D
authors.initials: CD
authors.lastname: Dickinson
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: William D
authors.initials: WD
authors.lastname: Huse
authors.forename: Keith S
authors.initials: KS
authors.lastname: Manchester
authors.forename: Jeffry D
authors.initials: JD
authors.lastname: Watkins
mesh_terms: D000818:Animals; D019020:Directed Molecular Evolution / Q000379:methods* / Q000639:trends; D006801:Humans; D015202:Protein Engineering / Q000379:methods* / Q000639:trends