[Effect of guizhi decoction on adenyl cyclase and phosphodiesterase in hypothalamus of rats models of fever and hypothermia].
OBJECTIVE
To observe the effect of Guizhi Decoction (GZD) on adenyl cyclase (AC) and phosphodiesterase (PDE) activities in hypothalamus of rat models of fever and hypothermia.


METHODS
The AC and PDE activities in hypothalamus were determined using radio-isotope method.


RESULTS
GZD could lower the AC activity in yeast induced fever rat model (P < 0.05), but cause rise of AC activity in aminopyrine induced hypothermia model (P < 0.05). No significant influence of GZD on PDE activity was shown in both fever or hypothermia models.


CONCLUSIONS
The bi-directional thermo-regulation effect of GZD might be partially due to influence on AC activity.
Qi
Y
Y
Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700.
Huo
H R
HR
Tian
J L
JL
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005334:Fever / Q000201:enzymology*; D007031:Hypothalamus / Q000201:enzymology*; D007035:Hypothermia / Q000201:enzymology; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases