title: A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5.
abstract: BACKGROUND
  Castleman's disease (CD), idiopathic lymph-node hyperplasia, is a heterogeneous disease of unknown origin. Although the pathophysiology is yet to be elucidated, interleukin (IL)-6 produced by swollen lymph nodes has been reported to play a crucial role in CD.
  
  
  METHODS
  This report presents a case of a 37-yr-old man with CD showing marked elevation of IL-6, hypereosinophilia, and also IL-5 elevation. To date, IL-5 has not been reported to influence CD. However, because in this case the serum concentration of IL-5 produced from swollen lymph nodes paralleled the general symptoms, IL-5, in addition to IL-6, may have played an important role in the disease.
  
  
  CONCLUSIONS
  Although in CD the serum IL-5 level is generally within the normal range, mild eosinophilia is a common complication of the disease. This case indicates that IL-5 can also influence eosinophilia. Taken together, this suggests that there may be a more general association between local production of IL-5 and the pathology of CD.
authors.affiliation: Division of Internal Medicine, Kinki Central Hospital, Itami City, Hyogo, Japan. ishiit@imed3.med.osaka-u.ac.jp
authors.forename: Taeko
authors.initials: T
authors.lastname: Ishii
authors.forename: Toyoshi
authors.initials: T
authors.lastname: Tatekawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koseto
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Masato
authors.initials: M
authors.lastname: Koike
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Saeki
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000097:blood / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000097:blood / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology
chemical_list: D015848:Interleukin-5; D015850:Interleukin-6