title: [A case-control study on risk factors for advanced schistosomiasis japonica].
abstract: OBJECTIVE
  To investigate risk factors for the development of advanced schistosomiasis.
  
  
  METHODS
  The case-control study was designed with a match of 1:1 and 1:2. Healthy persons and chronic schistosomiasis patients were used as control. Each group was composed of 213 cases. Items investigated included: history of schistosomiasis and treatment, exposure to the contaminated water, social-economical condition and nutritional status, other concomitant diseases. Cellular and humoral immunity, HBVMs and ABO blood groups were also detected. Statistical analysis was performed by 1:1 and 1:2 matched single and stepwise conditional logistic regression analysis with SAS software.
  
  
  RESULTS
  By stepwise conditional logistic regression analysis, it was revealed that number of schistosomiasis examination (OR = 1.168-1.311), interval from first infection to last treatment(OR = 1.142), interval from first infection to this investigation (OR = 1.089), HBsAg+ (OR = 4.683-10.759), HBcAb+ (OR = 2.873), HBsAg+ + HBeAb+ + HBcAb+ (OR = 7.64) were risk factors of developing advanced schistosomiasis. The average living space and cellular immunity were lower in advanced schistosomiasis patients than others. No association was found between advanced schistosomiasis and ABO blood groups.
  
  
  CONCLUSIONS
  The development of advanced schistosomiasis is associated with repeated infections, and delayed or incomplete treatment. Combined infection with hepatitis B, poor socio-economic conditions and impaired cellular immunity may increase the pathogenetic risk of schistosomiasis.
authors.affiliation: Jiangxi Medical College, Nanchang 330006.
authors.forename: Zhao-kang
authors.initials: ZK
authors.lastname: Yuan
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Hui-lie
authors.initials: HL
authors.lastname: Zheng
authors.forename: Han-qiang
authors.initials: HQ
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Yan
authors.forename: Nian-gao
authors.initials: NG
authors.lastname: Chen
authors.forename: Xiao-nan
authors.initials: XN
authors.lastname: Gu
authors.forename: Wei-zhou
authors.initials: WZ
authors.lastname: Wang
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Li
mesh_terms: D000017:ABO Blood-Group System; D016022:Case-Control Studies; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D016015:Logistic Models; D012307:Risk Factors; D012554:Schistosomiasis japonica / Q000209:etiology*
chemical_list: D000017:ABO Blood-Group System; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens