[Effect of wenjingtong composita on blood glucose and advanced glycosylation end products in sciatic nerve of streptozotocin-induced diabetic rats].
OBJECTIVE
To investigate the effect of Wenjingtong Composita (WJTC) on blood glucose and advanced glycosylation end products (AGEs) in sciatic nerve of streptozotocin (STZ)-induced diabetic rats.


METHODS
STZ-induced diabetic rats were randomized to WJTC prevention group and WJTC treatment group. The levels of blood glucose and AGEs in sciatic nerve of the animals were checked after 12 weeks treatment and compared with that of aminoguanidine (AG) treatment group.


RESULTS
Blood glucose level in the WJTC prevention and treatment group, and AGEs in sciatic nerve of the WJTC prevention group and the AG group were lower than those of the non-treated group (P < 0.01). Blood glucose level in the AG group was higher than that in the WJTC prevention group (P < 0.05), but was not significantly different from that in the non-treated group (P > 0.05).


CONCLUSIONS
WJTC might prevent diabetic peripheral neuropathy by decreasing blood glucose and inhibiting AGEs formation in sciatic nerve in STZ-induced diabetic rats.
Guo
Sai-shan
SS
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Tang
Dai-yi
DY
Liang
Xiao-chun
XC
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006031:Glycosylation / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000378:metabolism*; D020426:Sciatic Neuropathy / Q000378:metabolism
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D006146:Guanidines; C004479:pimagedine