X/XY/XYY mosaicism as a cause of subfertility in boars: a single case study.
Sex chromosome abnormalities are common in mammals and humans and are often associated with subfertility. In this study a boar with normal sperm parameters was indicated to have reduced prolificacy from figures obtained for return rate, farrowing rate and total number of piglets born. G-banded cytogenetic analysis of peripheral blood identified an abnormal mosaic sex chromosome constitution 39,XYY[74]/38,XY[23]/37,X[3]. Cytogenetic analysis of fibroblasts confirmed this mosaic karyotype with similar percentages of cell lines observed 39,XYY[76]/38,XY[19]/37,X[5]. External genitalia revealed a poorly developed scrotum with the right testicle being smaller than the left. To the best of our knowledge this is the first time that this chromosome constitution has been reported in the pig. It is of particular interest that this karyotype is associated with reduced boar fertility, which could lead to potential economic losses if such a boar were selected for breeding purposes.
Quilter
C R
CR
Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, UK. PIC UK. crq20@hermes.cam.ac.uk
Wood
D
D
Southwood
O I
OI
Griffin
D K
DK
D000818:Animals; D001947:Breeding; D020732:Cytogenetic Analysis; D005298:Fertility / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D009030:Mosaicism / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D013552:Swine / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*