Survival and normal neurological outcome after CPR with periodic Gz acceleration and vasopressin.
BACKGROUND
We showed previously that whole body periodic acceleration along the spinal axis (pGz) is a novel method of cardiopulmonary resuscitation (CPR). The ultimate assessment of the value of any CPR technique is the neurological outcome after using such a technique. In this study, we determined the neurological outcome in pigs after prolonged pGz-CPR, with administration of vasopressin immediately prior to defibrillation. Neurological outcome after pGz-CPR was compared to a control group where no intervention occurred for the same time period (C-NoInterv).


RESULTS
Ventricular Fibrillation (VFIB) was induced in 12 animals. After a 3 min non-interventional interval, the animals received either pGz-CPR (n=7), or C-NoInterv (n=5) for 15 min. After 18 min of VFIB, a single dose of vasopressin (0.8 U/kg) was administered along with sodium bicarbonate and bretylium, and defibrillation was attempted. All animals in the pGz-CPR group had return of spontaneous circulation (ROSC) and normal neurological assessment at 24 h. Neurologic outcome remained normal at 48 h. In contrast, none of the animals in the C-NoInterv had ROSC.


CONCLUSIONS
Prolonged pGz-CPR, with administration of vasopressin immediately prior to defibrillation results in normal neurological outcomes at 24 h.
Adams
Jose A
JA
Division of Neonatology, Department of Research, Mount Sinai Medical Center, Miami Beach, FL 33140, USA. tony@msmc.com
Bassuk
Jorge
J
Wu
Dongmei
D
Kurlansky
Paul
P
D000054:Acceleration; D000818:Animals; D002302:Cardiac Output / Q000502:physiology; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects* / Q000379:methods* / Q000401:mortality; D002560:Cerebrovascular Circulation / Q000502:physiology; D004554:Electric Countershock; D005260:Female; D008297:Male; D009460:Neurologic Examination; D011336:Probability; D011897:Random Allocation; D012016:Reference Values; D012032:Refractory Period, Electrophysiological; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013552:Swine; D016896:Treatment Outcome; D014667:Vasopressins / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000401:mortality / Q000628:therapy*
D014667:Vasopressins