title: Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns.
abstract: We tested the hypothesis that the administration of recombinant human growth hormone (rHGH) and exercise would increase lean body mass (LBM) and muscle strength in burned children to a greater extent than rHGH or exercise separately. Children, ages 7-17 yr, with >40% body surface area burned, were randomized into groups. One group (GHEX, n = 10) participated in a 12-wk in-hospital physical rehabilitation program supplemented with an exercise program and received 0.05 mg. kg(-1). day(-1) of rHGH. A second exercising group (SALEX, n = 13) received saline. A third group (GH, n = 10) received a similar dose of rHGH as GHEX and participated in a 12-wk, home-based physical rehabilitation program without exercise. The fourth group (Saline, n = 11) received saline and participated in a 12-wk, home-based physical rehabilitation program without exercise. The mean (+/-SE) percent change in lean body mass after 12 wk was not significantly different between GHEX (9.0 +/- 2.1%), SALEX (5.4 +/- 1.6%), and GH (5.8 +/- 1.8%) groups (P = 0.33). However, the mean percent change in muscle strength was significantly greater in the GHEX (36.2 +/- 5.4%) and SALEX (42.6 +/- 10.0%) groups than in the GH (-7.4 +/- 4.7%) or Saline (6.7 +/- 4.4%) groups (P = 0.008). In summary, rHGH GHEX, SALEX, and GH alone produced similar improvements in LBM. However, muscle strength was only increased via exercise.
authors.affiliation: Shriners Hospitals for Children, Galveston TX 77550, USA. oesuman@utmb.edu
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Suman
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Thomas
authors.forename: Judy P
authors.initials: JP
authors.lastname: Wilkins
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Mlcak
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002056:Burns / Q000503:physiopathology* / Q000534:rehabilitation / Q000628:therapy*; D002648:Child; D005081:Exercise Therapy; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D011994:Recombinant Proteins; D019382:Human Growth Hormone