Synthesis of potent and selective inhibitors against the proliferation of human coronary artery smooth muscle cells.
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity.
Ogita
Haruhisa
H
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Saitama, Japan.
Isobe
Yoshiaki
Y
Takaku
Haruo
H
Sekine
Rena
R
Goto
Yuso
Y
Misawa
Satoru
S
Hayashi
Hideya
H
D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism
D006131:Growth Inhibitors