Cytotoxicity of contact lens care solution to human corneal epithelium in vitro.
OBJECTIVE
To investigate the cytotoxicity of soft contact lens multi-purpose care solutions which are now in common use in China.


METHODS
The cell culture method was used. Cytotoxicity was indicated by significant increases in the number of dead cells relative to controls.


RESULTS
Cells were exposed to soft contact lens care solutions for 15 min. They were irregular in shape and variable in size. The intercellular space increased and variable in size. The intercellular space increased and the cells became scrunken. With the time of exposure elongated, damage of cells became more severe.


CONCLUSIONS
Four kinds of soft contact lens multi-purpose care solutions may have harmful effects on the culture of human corneal epithelial cells. Soaked lenses should be rinsed with saline before being placed in the eyes in order to reduce the potential toxicity of contact lens care solutions.
Gong
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X
Department of Optometry, Zhongshan Ophrhalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Zhong
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D002452:Cell Count; D002470:Cell Survival; D002478:Cells, Cultured; D018639:Contact Lens Solutions / Q000009:adverse effects / Q000633:toxicity*; D019573:Epithelium, Corneal / Q000166:cytology*; D006801:Humans
D018639:Contact Lens Solutions