[A fiber optic chemical sensor system for on-line monitoring the drug dissolution of rifampicin].
OBJECTIVE
To study a continuous, on-line and automatic monitoring method for dissolution of drugs.


METHODS
A new fiber optical chemical sensor prepared by sol-gel immobilization of molecular probe was reported. Based on multiple quenching of flurescence, an instrument and software system was designed to on-line monitor the drug dissolution of rifampicin.


RESULTS
The concentration of rifampicin was linear with ln(F0/F) when concentration was in the range of 10-170 micrograms/mL-1. The relative coefficient was 0.9993. The procession of dissolution can be on-line monitored. Parameters were obtained directly from the dissolution curve. There is no distinctly difference when compared with the method of the Pharmacopoeia of People's Republic of China (P > 0.05).


CONCLUSIONS
This procession analysis can reflect the real dissolution of drug and obtain the total information.
Li
Xin-xia
XX
Department of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.
Wang
Yu-wen
YW
Wang
Yan
Y
Chen
Jian
J
D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000737:chemistry; D002214:Capsules; D001330:Electronic Data Processing; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
D000904:Antibiotics, Antitubercular; D002214:Capsules; D012293:Rifampin