[Clinical study on treatment of children attention deficit hyperactivity disorder by jiangqian granule].
OBJECTIVE
To explore the effect of Jiangqian granule (JQG) in treating children attention deficit hyperactivity disorder (ADHD) and its mechanism.


METHODS
Eighty children with ADHD were randomly divided into two groups, the treated group treated with JQG and the control group treated with Ritalin. Blood lead concentration and Conners' scoring were measured before and after 3 months treatment and the therapeutic effects were assessed. Besides, blood lead concentration and Conners' scoring in 60 healthy children were also determined for control.


RESULTS
The total effective rate in the treated group and the control group was 92.5% and 72.5% respectively, significant difference existed between the two groups. Blood lead level and Conners' scores in ADHD patients were significantly higher than those in the healthy control (P < 0.01). The two parameters decreased after treatment in both groups, but the lowering was more significant in the treated group (P < 0.05, P < 0.01).


CONCLUSIONS
Blood lead concentration raised in ADHD patients, JQG could enhance the clinical therapeutic effect by means of reducing the blood lead.
Chen
Jian
J
Department of Pediatrics, Zhejiang TCM Hospital, Hangzhou 310006.
Chen
Yu-yan
YY
Wang
Xiao-ming
XM
D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007854:Lead / Q000097:blood*; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D008517:Phytotherapy
D000697:Central Nervous System Stimulants; D004365:Drugs, Chinese Herbal; D008774:Methylphenidate; D007854:Lead