A new role for SOCS in insulin action. Suppressor of cytokine signaling.
Suppressor of cytokine signaling (SOCS) family proteins were initially identified as inhibiting cytokine signaling pathways through a negative feedback loop involving the inhibition of Janus kinase activity. More recent data suggest that SOCS proteins may also modulate signaling mediated through receptor tyrosine kinases. Krebs and Hilton discuss research implicating SOCS-1 and SOCS-3 as inhibitors of insulin receptor-mediated and insulin-like growth factor-1 receptor-mediated signaling pathways, as well as the increasing evidence that SOCS proteins may act in part by participating in a ubiquitin ligase complex to promote the degradation of target proteins.
Krebs
Danielle L
DL
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia. krebs@wehi.edu.au
Hilton
Douglas J
DJ
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000502:physiology; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D018909:src Homology Domains / Q000502:physiology
D002352:Carrier Proteins; D016207:Cytokines; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D011506:Proteins; D012097:Repressor Proteins; C108944:SOCS1 protein, human; C106643:SOCS2 protein, human; C106644:SOCS3 protein, human; C108775:SOCS7 protein, human; C460659:Socs36E protein, Drosophila; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators; D014157:Transcription Factors