[An observation of the percutaneous absorption of total alkaloids and terpenoid lactones of Tripterygium wilfordii].
The main ingredients of Tripterygium wilfordii are total alkaloids and terpenoid lactones. The authors studied the percutaneous absorption of these compounds on mice by means of ultravillet spectrophotometry. The results showed that these alksloids and lactones could pass through the skin of the mice. The rate of 12-hour percutaneous absorption was 13.40% for the former and 17.60% for the latter. After the application of Tripterygium wilfordii adhesive plaster to the human skin for 12 hours, the two ingredients were absorbed 17.34% and 22.13% respectively. This suggests that Tripterygium wilfordii can really be administered through the skin.
Peng
D
D
Anhui College of TCM, Hefei, 230038.
Liu
Q
Q
Zhao
Z
Z
Huang
W
W
Qiu
J
J
D000287:Administration, Topical; D000470:Alkaloids / Q000493:pharmacokinetics*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007783:Lactones / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet; D013729:Terpenes / Q000493:pharmacokinetics; D013997:Time Factors; D029757:Tripterygium / Q000737:chemistry*
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007783:Lactones; D013729:Terpenes