[Detection of Epstein-Barr virus DNA in fine needle aspiration specimen from cervical lymphnodes with polymerase chain reaction].
OBJECTIVE
For the diagnosis of occult nasopharyngeal carcinoma.


METHODS
Epstein-Barr virus in 58 fine needle aspirations from cervical metastatic lymphnodes were detected with polymerase chain reaction.


RESULTS
The positive reaction was found in 28/35 metastatic carcinoma samples from middle or upside neck. Negative reaction was found in 3 lymphomas, 4 metastatic carcinomas in clavicular superior lymphnodes and 15/16 inflammatory diseases of cervical lymphnodes. The sensibility of this method for the diagnosis of nasopharyngeal carcinoma was 89.3%. The specificity was 86.7%.


CONCLUSIONS
The detection of Epstein-Barr virus in metastatic carcinoma from cervical lymphnodes had some clinical values for the diagnosis of occult nasopharyngeal carcinoma.
Lei
Z X
ZX
Department of Otolaryngology, Central Hospital of Jianghan Oil Field, Qianjiang, 433124.
Liu
Q R
QR
Yuan
P
P
D001707:Biopsy, Needle; D004279:DNA, Viral / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000821:virology; D008207:Lymphatic Metastasis; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009333:Neck; D016133:Polymerase Chain Reaction
D004279:DNA, Viral