[Effect of cadmium on the phagocytic function of polymorphonuclear leukocyte in mice tested by chemiluminescence of whole blood].
The effect of cadmium chloride on the immunological toxicity of polymorphonuclear leukocyte (PMN) and on lipid peroxidation in liver were measured by using the chemiluminesence of whole blood and thiobarbituric acid (TBA) method. The results showed that 0.1 and 10 mmol/L of cadmium chloride could accelerate the chemiluminesence of whole blood in vitro, but 1000 mmol/L of cadmium chloride inhibit the chemiluminesence. Two hours after the injection of cadmium chloride through caudal vein, chemiluminesence of whole blood was induced obviously at the dose of cadmium 1 and 100 micrograms/kg BW in vivo, but the chemiluminesence was inhibited at the dose of 500 and 1000 micrograms/kg BW. At the dose of 1 microgram/kg BW, the peroxidation of liver lipids was induced. The results suggested that cadmium at low concentration accelerated the immunity of PMN, while high concentration was toxic to PMN, cadmium at low concentration could accelerate the phagocytic function of phagocytes. Phagocytosis brings about excessive active oxygen in organism and intensifies the action of active oxygen on the lipid peroxidation in tissue cells, at last, results in organic oxidation injury.
Long
S
S
Guangxi Medical University, Nanning 530021, China.
Xie
Y
Y
Zhou
J
J
Liu
L
L
D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D019256:Cadmium Chloride