Cross-reactivity patterns to budesonide.
Allergic contact dermatitis from topical corticosteroids is not uncommon. Budesonide has been included in the European standard series as a marker for corticosteroid allergy, though little is known of its cross-reactivity with other corticosteroids. Twelve patients previously positive to budesonide on patch testing were given further patch and intradermal tests to a range of corticosteroids. Six patients previously negative to budesonide on patch testing were used as a control group. Budesonide cross-reacts with hydrocortisone-21-sodium phosphate and triamcinolone acetonide. Patients positive to budesonide should therefore avoid hydrocortisone and triamcinolone acetonide. Patch testing, unfortunately, is an inaccurate method of determining cross-reactivity patterns among corticosteroids.
Ferguson
A D
AD
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK. adam@fergusona2.freeserve.co.uk
Emerson
R M
RM
English
J S C
JS
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000737:chemistry; D019819:Budesonide / Q000009:adverse effects* / Q000737:chemistry; D016022:Case-Control Studies; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects / Q000737:chemistry; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D008775:Methylprednisolone / Q000009:adverse effects; D015394:Molecular Structure; D012882:Skin Tests / Q000379:methods; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; C039803:hydrocortisone sodium phosphate; D019819:Budesonide; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone; D008775:Methylprednisolone