A structural view of integrin activation and signaling.
Integrins connect the matrix to the cytoskeleton and propagate structural order between the two systems. A series of elegant structural papers now provides a compelling explanation of how integrins perform this basic function.
Giancotti
Filippo G
FG
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
D002448:Cell Adhesion; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins