title: A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus.
abstract: A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abbaskhan
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Yoshisuke
authors.initials: Y
authors.lastname: Tsuda
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez
authors.lastname: Atta-ur-Rahman
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
authors.forename: Zeba
authors.initials: Z
authors.lastname: Parween
authors.forename: Rasool Baksh
authors.initials: RB
authors.lastname: Tareen
authors.forename: Mudassir Asrar
authors.initials: MA
authors.lastname: Zaidi
mesh_terms: D018360:Crystallography, X-Ray; D037602:Isodon / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D014315:Triterpenes; C473345:rugosinin