title: Tris lipidation--a novel drug delivery system that alters biodistribution.
abstract: Tris-lipidation uses Tris to produce drug-fatty acyl conjugates. Radiolabelled Tris-fatty acyl conjugates of methotrexate (MTX) were examined in biodistribution studies in BALB/c mice. Following delivery via a variety of routes, the Tris-lipidated compounds demonstrated features in common with other colloid drug delivery systems. Tissues of the reticuloendothelial system localised the drug following intravenous administration, and the compounds showed prolongation at the site of injection into muscle or fatty tissue, subcutaneously or when inhaled. These findings indicate that the Tris-lipidation platform could be classed as an alternative colloid drug delivery system.
authors.affiliation: CSIRO Molecular Science, Riverside Corporate Park, Delhi Rd, PO Box 184, North Ryde, NSW 1670, Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Walker
authors.forename: Julie M
authors.initials: JM
authors.lastname: Fraser
authors.forename: Clayton E
authors.initials: CE
authors.lastname: Walton
authors.forename: Fred
authors.initials: F
authors.lastname: Widmer
authors.forename: Craig L
authors.initials: CL
authors.lastname: Francis
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.forename: Maree
authors.initials: M
authors.lastname: O'Sullivan
authors.forename: Robert G
authors.initials: RG
authors.lastname: Whittaker
authors.forename: Xanthe E
authors.initials: XE
authors.lastname: Wells
mesh_terms: D000818:Animals; D001682:Biological Availability; D003102:Colloids; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D008055:Lipids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D014325:Tromethamine / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D003102:Colloids; D008055:Lipids; D014325:Tromethamine