title: Determination of pKa values of 2-amino-2-oxazolines by capillary electrophoresis.
abstract: The dissociation constants of new 2-amino-2-oxazolines were determined by capillary electrophoresis (CE) as a new technique. A method based on a linear model has been used in the CE determination. A series of eight 2-amino-2-oxazolines are investigated to determine their ionization constant. Among them, three new oxazolines synthesized are presented. The Ka values were obtained from the plots of reciprocal effective mobility against inverse concentrations of protons. The potentiometric method (PM) was performed as a comparative method. No significant differences were observed between the determined dissociation constants using both methods. Thus, the pKa values have been found to vary between 8.55 and 8.68.
authors.affiliation: Chimie Analytique, EA 2962, UFR Sciences Pharmaceutiques, Université Bordeaux 2 Victor Segalen, 146 rue Léo Saignat, Case 110, 33076 Bordeaux Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Matoga
authors.forename: E
authors.initials: E
authors.lastname: Laborde-Kummer
authors.forename: M H
authors.initials: MH
authors.lastname: Langlois
authors.forename: P
authors.initials: P
authors.lastname: Dallet
authors.forename: J J
authors.initials: JJ
authors.lastname: Bosc
authors.forename: C
authors.initials: C
authors.lastname: Jarry
authors.forename: J P
authors.initials: JP
authors.lastname: Dubost
mesh_terms: D002021:Buffers; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles / Q000032:analysis*
chemical_list: D002021:Buffers; D010080:Oxazoles