title: Synthesis of potent and selective inhibitors against the proliferation of human coronary artery smooth muscle cells.
abstract: A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity.
authors.affiliation: Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Saitama, Japan.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Ogita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Isobe
authors.forename: Haruo
authors.initials: H
authors.lastname: Takaku
authors.forename: Rena
authors.initials: R
authors.lastname: Sekine
authors.forename: Yuso
authors.initials: Y
authors.lastname: Goto
authors.forename: Satoru
authors.initials: S
authors.lastname: Misawa
authors.forename: Hideya
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism
chemical_list: D006131:Growth Inhibitors