title: [Apolipoprotein E genotypes and carotid artery atherosclerosis in type 2 diabetes mellitus].
abstract: OBJECTIVE
  To investigate the relationship between carotid artery intima media thickness (IMT) and apolipoprotein (Apo) E gene polymorphisms in type 2 diabetes mellitus (DM2).
  
  
  METHODS
  Two hundred and fifty-five DM2 patients without angiopathy and 107 healthy individuals were selected. PCR/allele-specific oligonucleotide probe was used to determine their apoE genotypes.
  
  
  RESULTS
  The prevalence distribution of apoE genotypes and alleles in DM2 patients and that in controls were similar. The TC, LDL-C and Lp(a) concentrations in e4/4, e4/3 subgroups were significantly higher than those in e3/2, e2/2 subgroups (P<0.05). The average value of IMT in e4/4 e4/3 carriers (0.89 mm) was significantly greater than that in e3/2 e2/2 carriers (0.62 mm) (P<0.05). After adjustment for TC, LDL-C, TG, Lp(a), FBG, HbA1c, age, BMI, and smoking, ANCOVA showed that the average value of carotid IMT was significantly greater in subjects with e4/4 e4/3, compared with that in subjects with e3/2 e2/2(P=0.033).
  
  
  CONCLUSIONS
  Apo e4 allele increases the risk for carotid artery atherosclerosis in the early stage of diabetic population.
authors.affiliation: Department of Endocrinology, Wuhan General Hospital of PLA, Wuhan, Hubei, PR China. Guangda64@163.net
authors.forename: Guang-da
authors.initials: GD
authors.lastname: Xiang
authors.forename: Tai-hong
authors.initials: TH
authors.lastname: Hu
authors.forename: Yun-lin
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001161:Arteriosclerosis / Q000473:pathology*; D015992:Body Mass Index; D002340:Carotid Artery Diseases / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002784:Cholesterol; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D017270:Lipoprotein(a); D014280:Triglycerides