[Effects of kidney reinforcing and blood circulation activating Chinese medicine on morphological structure of mammary glands in models of mammary atrophy and hyperplasia in female rats].
OBJECTIVE
To study the effects and mechanism of Kidney reinforcing and blood circulation activating Chinese medicine (K&B) on morphologic structure of mammary glands in female rat models of mammary atrophy and mammary hyperplasia.


METHODS
The models of mammary gland atrophy and hyperplasia were established respectively by ovariectomy and diethylstilbestrol injection to observe the changes of gland's weight index, structure, estradiol receptor (ER) and progesterone receptor (PR) after treated by K&B.


RESULTS
(1) K&B could ameliorate the atrophied structure of mammary gland with significant increase of weight index (P < 0.01), raise the number of ER and PR in mammary tissue and nuclei (P < 0.01, P < 0.05), normalize the ratios of ER and PR in plasma and those in nucleus (EnR/EcR and PnR/PcR). (2) K&B could also improve or restore the proliferated structure of mammary gland and its weight index as well as the EnR/EcR and PnR/PcR ratios.


CONCLUSIONS
K&B has the effects in preventing and improving the mammary gland atrophy induced by hyposecretion of sexual hormone and promoting the development of mammary gland in adult rats. Although both K&B and estrogen can improve the development of mammary gland, their mechanisms are different. There is a bright future of K&B in treating underdevelopment of mammary gland.
Li
P Y
PY
First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405.
Ouyang
H Q
HQ
D000818:Animals; D001284:Atrophy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D011959:Receptors, Estradiol / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone