title: Lansium domesticum: skin and leaf extracts of this fruit tree interrupt the lifecycle of Plasmodium falciparum, and are active towards a chloroquine-resistant strain of the parasite (T9) in vitro.
abstract: Malaria remains a global problem in the light of chloroquine-resistant strains of Plasmodium falciparum. New compounds are needed for the development of novel antimalarial drugs. Seed, leaf, and fruit skin extracts of Lansium domesticum, a common fruit tree in South-East Asia, are used by indigenous tribes in Sabah, Malaysia for treating malaria. The skin and aqueous leaf extracts of the tree were found to reduce parasite populations of the drug sensitive strain (3D7) and the chloroquine-resistant strain (T9) of P. falciparum equally well. The skin extracts were also found to interrupt the lifecycle of the parasite. The data reported here indicate that extracts of L. domesticum are a potential source for compounds with activity towards chloroquine-resistant strains of P. falciparum.
authors.affiliation: The Institute of Health and Community Medicine, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Malaysia. dyapp@bccancer.bc.ca
authors.forename: Donald T T
authors.initials: DT
authors.lastname: Yapp
authors.forename: S Y
authors.initials: SY
authors.lastname: Yap
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D005638:Fruit / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D008018:Life Cycle Stages / Q000187:drug effects; D029582:Meliaceae; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine