[Effect of natrahagin, a Chinese cobra venom proteinase on hemorrheology in rat].
The effects of natrahagin, a Chinese cobra venom proteinase on hemorrheology and plasma fibrinogen level in rat was investigated. The results showed that intravenous injection of natrahagin (0.025-0.1 mg/kg) dose-dependently decreased the whole blood viscosity and the plasma viscosity (P < 0.05 or P < 0.01) in rat, but caused no significant effect on hematocrit (P > 0.05). Natrahagin also decreased the plasma fibrinogen level (P < 0.05 or P < 0.01) of rat in a dose-dependent manner at these doses.
Guo
D
D
Pharmaceutical Department of Nanfang Hospital, the First Military Medical University, Guangzhou 510515.
Hou
L
L
Chen
Z
Z
Wu
S
S
Chen
N
N
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000737:chemistry; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D008297:Male; D008666:Metalloendopeptidases / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D004546:Elapid Venoms; D005343:Fibrinolytic Agents; D005340:Fibrinogen; D008666:Metalloendopeptidases; C424242:natrahagin