title: [Infiltration of local anesthetics into the thyroid gland capsule for surgery and the postoperative period].
abstract: In a prospective randomized study the hypothesis was tested whether infiltration of the thyroid capsule by a local anaesthetic will reduce the haemodynamic response to surgical trauma, consumption of anaesthetics and opioids during surgery and will shorten the time of arousal. A total of 64 patients indicated for planned goitre surgery were divided at random into a control group (C, n = 32) and experimental group (LA, n = 32). The preoperative medication and anesthesia did not differ in the two groups. In group C into the thyroid capsule a maximum of 40 ml saline was administered, in LA the same volume of 0.5% trimecain. A highly significant difference was found (p < 0.001) in the incidence of hypertension during surgery (21 C vs. 5 LA) and the need of further pharmacological interventions (21 vs. 8). In the control group was a higher consumption (p < 0.95) of the opioid phentanyl (167.5 +/- 111 micrograms vs. 125 +/- 93.5 micrograms), a trend of longer arousal and the need to antagonize the effect of opioid (p < 0.1). The substitution of saline by a local anaesthetic for infiltration of the thyroid capsule is a safe and simple method leading to a reduction of cardiovascular complications during surgery.
authors.affiliation: Chirurgická klinika FNKV, Praha.
authors.forename: B
authors.initials: B
authors.lastname: Vach
authors.forename: A
authors.initials: A
authors.lastname: Kurzová
authors.forename: J
authors.initials: J
authors.lastname: Málek
authors.forename: J
authors.initials: J
authors.lastname: Fanta
authors.forename: J
authors.initials: J
authors.lastname: Pachl
mesh_terms: D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control; D011446:Prospective Studies; D013961:Thyroid Gland; D013965:Thyroidectomy; D014288:Trimecaine / Q000008:administration & dosage*
chemical_list: D000779:Anesthetics, Local; D014288:Trimecaine