Resistance to beta-lactams among blood isolates of Salmonella spp. in European hospitals: results from the SENTRY Antimicrobial Surveillance Program 1997-98.
The susceptibility to beta-lactams and the beta-lactamase content of 110 Salmonella spp. blood isolates collected during 1997-98 in 19 European centers participating in the SENTRY Surveillance Program were studied. Thirty-one isolates (28%) were resistant to penicillins, due to production of TEM-1 (27 isolates), OXA-1 (three isolates) or TEM-1 + OXA-1 (one isolate). All OXA-1 producers and 10 TEM-1-producing isolates were also resistant to penicillin-clavulanic acid combinations. In the latter isolates, this phenotype was associated with increased production of TEM-1. Sixteen TEM-1-producing Salmonella Enteritidis isolates and one OXA-1-producing S. Typhimurium isolate were able to transfer beta-lactam resistance by conjugation.
Tzouvelekis
L S
LS
Department of Microbiology, Medical School, University of Athens, Athens, Greece.
Lukova
V
V
Tassios
P T
PT
Fluit
A C
AC
Jones
R N
RN
Legakis
N J
NJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005060:Europe; D006801:Humans; D007526:Isoelectric Point; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D012480:Salmonella Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology; D012477:Salmonella enteritidis / Q000187:drug effects* / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000302:isolation & purification; D018440:beta-Lactam Resistance / Q000502:physiology*; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D047090:beta-Lactams; D001618:beta-Lactamases