[Distribution of 5-fluorouracil in plasma and pancreatic tissue of rats during the regional arterial infusion chemotherapy].
OBJECTIVE
Compare the pharmacokinetic parameters of 5-FU in the regional arterial infusion chemotherapy with those in the intravenous chemotherapy.


METHODS
Wistar rats were randomly divided into two groups: the intravenous group and the regional arterial infusion group. HPLC was used to measure the concentration of 5-FU in the plasma and the pancreas tissue. Penetration index was calculated.


RESULTS
In the intravenous group, maximum concentration (Cmax) of 5-FU in the pancreas was 8.42 micrograms/g and the clearance time of the pancreas was 50 min. In the regional arterial infusion group, Cmax of 5-FU in the pancreas was 20.00 micrograms/g and the clearance time of the pancreas was 90 min. They were both greater than those of the intravenous group. Rd was 2.42.


CONCLUSIONS
The regional arterial infusion chemotherapy is a better way for treating pancreatic carcinoma than the intravenous chemotherapy.
Tao
W
W
Department of Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730.
Zhao
Y
Y
Cai
L
L
Zhu
Y
Y
D000818:Animals; D019540:Area Under Curve; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics*; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D010179:Pancreas / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D005472:Fluorouracil