title: Cytogenetic study of non-Hodgkin lymphoma from South India. histologic and geographic correlations.
abstract: Cytogenetic analysis of fine needle aspiration cultures was performed on 189 patients with non-Hodgkin lymphoma from South India. Successful karyotyping was possible in 97 patients (51.3%). Burkitt lymphoma constituted 56% of the cases studied followed by diffuse type 20%, follicular 8.8%, lymphoblastic 6.6%, and unclassified 6.6%. Characteristic chromosomal translocations were t(8;14)(q24;q32) [32.2%], t(8;22)(q24;q11) [10%], t(2;8)(p12;q24) [2.2%], t(14;18)(q34;q21) [3.3%], and t(11;14)(q23;q32) [2.2%]. Notable geographical variation of some structural abnormalities was the finding in the present study such as, lower frequency of t(14;18) in follicular lymphomas and higher frequency of t(8;14) in Burkitt lymphomas when compared with the Western studies.
authors.affiliation: Department of Pathology, Kidwai Memorial Institute of Oncology, 560 029, Bangalore, India.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Kumari
authors.forename: Geetashree
authors.initials: G
authors.lastname: Mukherjee
authors.forename: Clementina Rama
authors.initials: CR
authors.lastname: Rao
authors.forename: Muniyappa Gayathri
authors.initials: MG
authors.lastname: Devi
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Biswas
authors.forename: Lingegowda
authors.initials: L
authors.lastname: Appaji
authors.forename: Bandagadde S
authors.initials: BS
authors.lastname: Arunakumari
authors.forename: Maneya
authors.initials: M
authors.lastname: Padma
authors.forename: Poonamallee Parthasarthy
authors.initials: PP
authors.lastname: Bapsy
authors.forename: Tambarahalli S
authors.initials: TS
authors.lastname: Sundareshan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000453:epidemiology / Q000235:genetics; D008224:Lymphoma, Follicular / Q000453:epidemiology / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged