title: Small pulmonary nodules: detection at chest CT and outcome.
abstract: OBJECTIVE
  To determine the outcome of pulmonary nodules less than 1 cm in diameter detected at chest computed tomography (CT).
  
  
  METHODS
  Reports of chest CT performed during 6 months were reviewed to find patients with pulmonary nodules smaller than 1 cm in long axis for which repeat CT was recommended. Records were studied to determine whether follow-up had been performed, the initial nodules had changed in size, or nodules had been resected.
  
  
  RESULTS
  A total of 3,446 chest CT examinations were performed, with 334 patients meeting inclusion criteria. Three patients underwent nodule resection and had pathologic examination results positive for cancer; 185 underwent follow-up, of whom 13 had results excluded as indeterminate. In the remaining 172 patients, 88 had incomplete characterization because of follow-up of less than 2 years, which left 84 with nodule characterization at follow-up. When these 84 patients were combined with the three patients with nodule resection, the number yielded was 87 patients. Seventy-seven of 87 had benign nodules because of resolution or 2-year stability, and 10 of 87 had malignant nodules because of growth or positive histologic examination results. Nine of 10 with malignant nodules had a known primary neoplasm.
  
  
  CONCLUSIONS
  CT commonly helped identify small nodules. Increase in size occurred infrequently and almost exclusively in patients with a known malignancy.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Founders House 2-202B, Boston, MA 02114, USA. matthew.benjamin@uhn.on.ca
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Benjamin
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Drucker
authors.forename: Theresa C
authors.initials: TC
authors.lastname: McLoud
authors.forename: Jo-Anne O
authors.initials: JA
authors.lastname: Shepard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome