[The study and comparative evaluation of the actoprotective activity of ATF-LONG in experiment].
In the paper, results are reflected of a swimming test in 78 laboratory rats. ATF-LONG has been shown to be capable of augmenting the animals' powers of endurance during loading tests. The established dose-dependent actoprotective activity of ATF-LONG is superior to that of adenosine triphosphate, trimetasidine (preductal), and mildronate. Possible pharmacological mechanisms of its actoprotective activity are discussed. The authors come to the conclusion that performance capability gets improved under exposure to purine nucleotides.
Moroz
V M
VM
Lipnitskiĭ
T N
TN
Kutniak
V P
VP
Kozlovskiĭ
V A
VA
Bandurka
N M
NM
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology; D010805:Physical Conditioning, Animal / Q000502:physiology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013550:Swimming; D014292:Trimetazidine / Q000494:pharmacology
D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D000255:Adenosine Triphosphate; D014292:Trimetazidine