title: Aseptic necrosis of both femoral heads as first symptom of chronic myelogenous leukemia.
abstract: Chronic myelogenous leukemia (CML) is a disease of the elderly; in rare cases it occurs in childhood or adolescence. One complication at primary diagnosis is leukostasis, which usually causes respiratory, retinal, or central nervous symptoms. In this report we describe the case of a 24-year-old woman who developed aseptic necrosis of both femoral heads, which was successfully treated by bore holes in the femoral heads. This is a very rare complication of severe leukostasis, leading to the diagnosis of CML in this case. To our knowledge, this is the first case of an adult patient showing aseptic necrosis of femoral heads caused by leukostasis.
authors.affiliation: Medizinische Poliklinik, University of Wuerzburg, Klinikstr. 8, 97070 Wuerzburg, Germany. d.kraemer@medizin.uni-wuerzburg.de
authors.forename: M
authors.initials: M
authors.lastname: Kraemer
authors.forename: F
authors.initials: F
authors.lastname: Weissinger
authors.forename: R
authors.initials: R
authors.lastname: Kraus
authors.forename: M
authors.initials: M
authors.lastname: Beer
authors.forename: V
authors.initials: V
authors.lastname: Kunzmann
authors.forename: M
authors.initials: M
authors.lastname: Wilhelm
mesh_terms: D000328:Adult; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology / Q000628:therapy; D018921:Leukostasis / Q000150:complications; D008279:Magnetic Resonance Imaging; D012074:Remission Induction; D014184:Transplantation, Homologous