title: Organophosphate-induced delayed neuropathy: case report.
abstract: Organophosphate induced delayed neuropathy (OPIDN) is an uncommon clinical condition. It occurs in association with the ingestion of great amounts of organophosphate after the stimulation of cholinergic receptor. The clinical picture is characterized by a distal paresis in lower limbs associated with sensitive symptoms. Electrodiagnostic studies show a motor axonal neuropathy. Involvement of the central nervous system may occur. We describe a 39 years-old female patient who developed hyperesthesia associated with lower limbs paresis, fourteen days after she had ingested a Dichlorvos-based insecticide. Electrophysiological study was characterized by an axonal polyneuropathy pattern. Pyramidal tract dysfunction was observed later in upper limbs. Considering that both peripheral and central nervous systems are involved we believe that the more appropriated term would be organophosphate induced delayed neuropathy (OPIDN) instead of organophosphate induced delayed polyneuropathy (OPIDP).
authors.affiliation: Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brasil. luizfrv@ig.com.br
authors.forename: Luiz Felipe R
authors.initials: LF
authors.lastname: Vasconcellos
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Leite
authors.forename: Osvaldo J M
authors.initials: OJ
authors.lastname: Nascimento
mesh_terms: D000328:Adult; D004006:Dichlorvos / Q000506:poisoning*; D005260:Female; D006801:Humans; D006941:Hyperesthesia / Q000139:chemically induced / Q000175:diagnosis; D007306:Insecticides / Q000506:poisoning*; D009046:Motor Neurons / Q000187:drug effects*; D010291:Paresis / Q000139:chemically induced / Q000175:diagnosis; D011115:Polyneuropathies / Q000139:chemically induced* / Q000175:diagnosis; D013406:Suicide, Attempted; D013997:Time Factors
chemical_list: D007306:Insecticides; D004006:Dichlorvos