[Study on the expression of adhesion molecule related proteins in patients with coronary heart disease].
OBJECTIVE
To assess the expression level of adhesion molecule related proteins CD11a and CD11b on neutrophils, monocytes and lymphocytes in patients with coronary heart disease and detect the relation of expression level to the degree of stenosis of coronary arteries and the severity of coronary heart disease.


METHODS
The subjects were divided into three groups: stable angina, unstable angina, and healthy people as control. The amount of cell adhesion molecule related proteins CD11a and CD11b on neutrophilic granulocytes, monocytes and lymphocytes of peripheral blood was measured in three groups by using fluorescent immunoassay method on flow cytometer. Relationship between them was analysed.


RESULTS
No significant difference in the expression of CD11a between the angina and control groups was observed. The expression of CD11b on lymphocytes and neutrophilic granulocytes in the unstable angina group and stable angina group was significantly higher than that in the healthy people(P < 0.01 and P < 0.05). Although the amount of CD11b measured in the group of severe coronary artery stenosis was higher than that measured in the mild light group, the difference was not significant (P > 0.05).


CONCLUSIONS
The amount of adhesion molecule related protein CD11b on neutrophilic granulocytes and lymphocytes in patients with unstable angina is higher than that in patients with stable angina and control group, but there is no relationship between the expression level of CD11b and the degree of coronary stenosis.
Chen
Xiaoping
X
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Dingbao
D
Yang
Qing
Q
Huang
Dejia
D
Zhang
Li
L
Gao
Mei
M
Lei
Song
S
Huang
Minghui
M
Liu
Xiaojing
X
Wei
Yuqan
Y
You
Guiying
G
D000328:Adult; D000368:Aged; D040881:CD11a Antigen / Q000096:biosynthesis*; D039481:CD11b Antigen / Q000096:biosynthesis*; D003327:Coronary Disease / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D016231:Fluorescence Polarization Immunoassay / Q000379:methods; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D040881:CD11a Antigen; D039481:CD11b Antigen