[Studies on pharmacokinetics of chloroquine in mice infected with chloroquine-resistant strain of Plasmodium berghei].
OBJECTIVE
To compare the pharmacokinetic differences of chloroquine in normal mice and the mice infected with the N and the RC strains of Plasmodium berghei.


METHODS
The concentrations of chloroquine in the plasma of normal mice and the mice infected with the N or the RC strains of P. berghei were analyzed by reverse-phase HPLC. The pharmacokinetic parameters were measured with software 3P87.


RESULTS
The t1/2 beta value was significantly lower in the mice infected with the RC strain than in normal mice and the mice infected with the N strain(P < 0.05), however, there were no significant differences between the mice infected with the N strain and normal mice.


CONCLUSIONS
Elimination of chloroquine in the mice infected with the RC strain of P. berghei speed up significantly comparing with the mice infected with the N strain.
Shi
J
J
Department of Etiological Biology, Faculty of Basic Medicine Sciences, Second Military Medical University, Shanghai 200433.
Song
G H
GH
Ni
Y C
YC
Wang
M J
MJ
D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000494:pharmacology; D002738:Chloroquine / Q000493:pharmacokinetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004351:Drug Resistance; D005260:Female; D008288:Malaria / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei / Q000187:drug effects
D000962:Antimalarials; D002738:Chloroquine