Prenatal diagnosis of occipital encephalocele, mega-cisterna magna, mesomelic shortening, and clubfeet associated with pure tetrasomy 20p.
We present the first case of a fetus with pure tetrasomy 20p proven by cord-blood sampling at 24 weeks of gestation. This case was diagnosed in utero with multiple congenital anomalies including occipital encephalocele, mega-cisterna magna, mesomelic shortening, and clubfeet. An analysis of GTG-banded chromosomes of 20 metaphase cells was performed. Female karyotype [47,XX, +i(20)(p10)] was revealed in all cells. Pure tetrasomy 20p was confirmed using fluorescent in situ hybridization (FISH) with a telomere probe for chromosome 20p in all seven metaphase cells. The pregnancy was terminated because of associated multiple anomalies and severe oligohydramnios. The postmortem examination confirmed the prenatal diagnosis.
Wu
Yi-Cheng
YC
Department of Obstetrics and Gynecology, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Section 2, Taipei, Taiwan, ROC. ycwu@vghtpe.gov.tw
Fang
Jye Siung
JS
Lee
Kuei-Fang
KF
Estipona
Judy
J
Yang
Man-Li
ML
Yuan
Chiou-Chung
CC
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000235:genetics; D000025:Abortion, Eugenic; D000328:Adult; D000782:Aneuploidy; D002871:Chromosome Banding; D002890:Chromosomes, Human, Pair 20; D002946:Cisterna Magna / Q000002:abnormalities*; D003025:Clubfoot / Q000175:diagnosis* / Q000235:genetics; D004677:Encephalocele / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D018404:Isochromosomes; D008214:Lymphocytes / Q000166:cytology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D032681:Spectral Karyotyping