Organ preservation trials for laryngeal cancer.
Organ-preservation strategies include definitive radiation therapy alone, induction chemotherapy followed by radiotherapy, and concurrent chemoradiotherapy. Over the past decade, induction chemotherapy followed by radiotherapy has been the standard for the nonsurgical management of advanced laryngeal cancer. Over this same period, however, other nonsurgical strategies have been under evaluation. These approaches include radiotherapy with concurrent chemotherapy to take advantage of the radiosensitizing properties of most cytotoxic drugs with activity against squamous cell cancer, altered fractionation radiotherapy, and the incorporation of molecularly targeted therapeutics into multimodality treatment.
Gilbert
Jill
J
Louisiana State University, Health Sciences Center Stanley, C. Scott Cancer Center, 433 Bolivar Street, New Orleans, LA 70112, USA.
Forastiere
Arlene A
AA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic
D002945:Cisplatin; D005472:Fluorouracil