[Dynamic changes in IL-4, IL-5 and IL-10 in liver and bone marrow of mice infected with Schistosoma japonicum].
OBJECTIVE
To observe the changes in Th2 cytokines in the liver and bone marrow of mice infected with schistosomiasis japonica.


METHODS
ABC immunohistochemical staining technique and multimedia pathological picture analysis were used. Meanwhile, IL-4, IL-5 and IL-10 derived from livers and bone marrows of infected mice were observed at wk 8, 10 and 12 after infection.


CONCLUSIONS
In the livers of infected mice, the levels of IL-4, IL-5 and IL-10 increased obviously with a prolongation of the infection duration, IL-4 being the highest. However, in the bone marrow of infected mice, IL-4 level increased slowly with the duration of the infection, being lower than those in the liver at wk 10 and 12 after infection. The level of IL-5 was higher than that in the liver within 12 wk. At wk 10 after infection IL-10 tended to increase, but decreased thereafter and was obviously lower than that in the liver. In mice infected with Schistosoma japonicum, the immune response occurred mainly in the liver. IL-5 in the bone marrow showed auto-secretion.
Zeng
L
L
Department of Infectious Diseases, Union Hospital, Tongji Medical University, Wuhan 430022.
Luo
D
D
Liu
W
W
Guo
J
J
Li
S
S
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D012554:Schistosomiasis japonica / Q000378:metabolism*
D015848:Interleukin-5; D016753:Interleukin-10; D015847:Interleukin-4