[Study for effect of kangyanling on cytokine and C-reactive protein in patients of systemic inflammatory reaction syndrome and multi-organ dysfunction syndrome after abdominal surgery].
OBJECTIVE
To observe the clinical effect and mechanism of Kangyanling (KYL) in treating patients with systemic inflammatory reaction syndrome and multi-organ dysfunction syndrome (SIRS/MODS) after abdominal surgery.


METHODS
Eighty-two patients of SIRS/MODS after abdominal surgery were divided into two groups according to admission time, the KYL treated group (n = 35) and the control group (n = 47). The levels of serum C-reactive protein (CRP), plasma tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were measured at the 1st, 3rd and 7th day post-operationally.


RESULTS
The levels of CRP, TNF-alpha and IL-6 decreased gradually after surgical operation in both groups, but the reducing velocity was shorter in the KYL group than that in the control group, so the comparison of the levels in the two group showed significant difference on the 3rd day after operation (P < 0.05).


CONCLUSIONS
KYL could inhibit the release of inflammatory mediator and relieve the inflammatory response so as to treat post-operational SIRS/MODS effectively.
Chen
Z Y
ZY
Baodi District Hospital of Tianjin 301800.
Qi
Q H
QH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D002763:Cholecystectomy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein