title: Does cyclophosphamide benefit relapsing thrombotic thrombocytopenic purpura?
abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare disease. A high index of suspicion is required for early diagnosis and treatment. It can present in acute as well as chronic forms. Cyclophosphamide has been reported to be beneficial in relapsing TTP. Herein a case of acute TTP evolving into relapsing phase of the disease is presented. Cyclophosphamide in our case achieved partial remission without the need for plasma exchange therapy. The rationale of cyclophosphamide in management of relapsing TTP is discussed.
authors.affiliation: Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: V
authors.initials: V
authors.lastname: Agarwal
authors.forename: B L
authors.initials: BL
authors.lastname: Sharma
authors.forename: Amita
authors.initials: A
authors.lastname: Aggarwal
authors.forename: R
authors.initials: R
authors.lastname: Misra
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000628:therapy*; D012008:Recurrence
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide