title: [Clinical significance of the detection of the sL-selectin level in patients with acute leukemia].
abstract: OBJECTIVE
  To study the relationship between the episode and state of acute leukemia and the level of soluble L-selectin (sL-selectin) in the plasma and cerebrospinal fluid.
  
  
  METHODS
  With a sandwich enzyme-linked immunosorbent assay (ELISA), the levels of sL-selectin in the plasma of 40 patients with acute leukemia and in the cerebrospinal fluid of 28 patients with acute lymphoblastic leukemia were measured, and compared with 20 controls.
  
  
  RESULTS
  The levels of sL-selectin were significantly higher in the patients with untreated and therapy-resistant acute leukemia or leukemia relapse than those in the complete remission patients and the controls (P < 0.001). The levels of SL-selectin were related to the clinical course of acute leukemia.
  
  
  CONCLUSIONS
  Monitoring the sL-selectin level may be useful for evaluating leukemia activity, in particular for the detection of leukemia relapse and meningeal infiltration.
authors.affiliation: Department of Clinical Haematology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Chang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Qi
authors.forename: Min
authors.initials: M
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000097:blood* / Q000134:cerebrospinal fluid; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000134:cerebrospinal fluid
chemical_list: D014408:Biomarkers, Tumor; D019041:L-Selectin