GenePath: a system for automated construction of genetic networks from mutant data.
BACKGROUND
Genetic networks are often used in the analysis of biological phenomena. In classical genetics, they are constructed manually from experimental data on mutants. The field lacks formalism to guide such analysis, and accounting for all the data becomes complicated when large amounts of data are considered.


RESULTS
We have developed GenePath, an intelligent assistant that automates the analysis of genetic data. GenePath employs expert-defined patterns to uncover gene relations from the data, and uses these relations as constraints in the search for a plausible genetic network. GenePath formalizes genetic data analysis, facilitates the consideration of all the available data in a consistent manner, and the examination of the large number of possible consequences of planned experiments. It also provides an explanation mechanism that traces every finding to the pertinent data.


BACKGROUND
GenePath can be accessed at http://genepath.org.


BACKGROUND
Supplementary material is available at http://genepath.org/bi-.supp.
Zupan
Blaz
B
University of Ljubljana, Faculty of Computer and Information Science Jozef Stefan Institute, Ljubljana, Slovenia.
Demsar
Janez
J
Bratko
Ivan
I
Juvan
Peter
P
Halter
John A
JA
Kuspa
Adam
A
Shaulsky
Gad
G
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development; D004252:DNA Mutational Analysis / Q000379:methods*; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development; D005103:Expert Systems; D005786:Gene Expression Regulation / Q000502:physiology*; D007814:Larva / Q000235:genetics / Q000254:growth & development; D008957:Models, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D016037:Single-Blind Method; D012984:Software