[Telomerase Activity Expressed in Acute Leukemia Cell]
To explore the possible linkage between telomerase and acute leukemia, we detected telomerase activity expressed in 3 leukemia cell lines, 22 acute leukemia bone marrow and 6 normal bone marrow with PCR ELISA assay. Results showed that telomerase activities of three leukemia cell lines were positive with the average (1.57 +/- 0.056) U, normal bone marrow samples average was (0.085 +/- 0.081) U, telomerase value from 22 acute leukemia patients was (0.512 +/- 0.294) U. Telomerase activity is higher expressed in acute leukemia than normal samples and decreased significantly after chemotherapy (P < 0.01). The results suggested that telomerase activity was related to some malignant diseases and might be used as a marker for tumor diagnosis and therapy.
Xi
Rui
R
Department of Hematology and Digestion, The General Military Regional Hospital of Lanzhou, Lanzhou 730050, China.
Zhang
Fang-Xin
FX
Ou
Ying-Xian
YX
Bai
Hai
H
Wei
Ya-Ming
YM
Xie
Dong-Xu
DX