Factors regulating the metastatic potential of benign giant cell tumour of bone--study of an unusual case with short review of literature.
Benign giant cell tumour of bone with metastases to other bones and lungs is extremely rare. Benign metastasising giant cell tumour is distinctly separate from multicentric giant cell tumour, primary and secondary malignant giant cell tumour. Factors regulating the local recurrence and metastatic potential of this benign tumour depend on its aggressiveness which can be better assessed by clinical and radiological parameters rather than the histopathological appearance. A benign giant cell tumour of ischium with metastasis to vertebra and lung over an eleven year period is discussed. Extreme paucity of literature prompted to publish the article. A short review of factors determining the recurrence and metastatic spread of benign giant cell tumour of bone is highlighted.
Mondal
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Department of Pathology, SVS Marwari Hospital and Cancer Detection Centre, Calcutta.
Kundu
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Misra
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DK
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000556:secondary*; D009362:Neoplasm Metastasis; D013125:Spinal Neoplasms / Q000473:pathology; D013977:Tibia