Syntheses, characterization and DNA-binding studies of ruthenium(II) terpyridine complexes: [Ru(tpy)(PHBI)]2+ and [Ru(tpy)(PHNI)]2+.
Two novel tridentate ligands, 2-(2-benzimidazole)-1,10-phenanthroline (PHBI) and 2-(2-naphthoimidazole)-1,10-phenanthroline (PHNI), and their heteroleptic complexes [Ru(tpy)(PHBI)](ClO(4))(2).2H(2)O (1) and [Ru(tpy)(PHNI)](ClO(4))(2).H(2)O (2) (tpy=2,2':6',2"-terpyridyl) have been synthesized and characterized by elemental analysis, mass spectra, 1H NMR, and electronic spectroscopy. The electrochemical behaviors of the two novel complexes were studied by cyclic voltammetry. The DNA-binding properties of the two complexes were investigated by spectroscopic methods and viscosity measurements. The results indicated that the two complexes interact with DNA in different binding modes. Complex 1 may bind to DNA via electrostatic interaction, while complex 2 binds to DNA by partial intercalation via the extended naphthyl ring into the base pairs of DNA.
Jiang
Cai-Wu
CW
School of Chemistry & Chemical Engineering, Zhongshan University, 510275 Guangzhou, China.
Chao
Hui
H
Li
Hong
H
Ji
Liang-Nian
LN
D001562:Benzimidazoles / Q000737:chemistry; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004563:Electrochemistry; D004577:Electron Probe Microanalysis; D007093:Imidazoles / Q000737:chemistry; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013057:Spectrum Analysis
C474865:2-(2-benzimidazole)-1,10-phenanthroline; C474864:2-(2-naphthoimidazole)-1,10-phenanthroline; D001562:Benzimidazoles; D007093:Imidazoles; D007364:Intercalating Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D012428:Ruthenium; D004247:DNA