[Clinical observation on effect of Chinese herbal medicine plus human chorionic gonadotropin and progesterone in treating anticardiolipin antibody-positive early recurrent spontaneous abortion].
OBJECTIVE
To find a method without corticosteroids, aspirin or heparin for treatment of anticardiolipin antibody-positive early recurrent spontaneous abortion (AARSA).


METHODS
Twenty-three patients of AARSA in the treated group were treated with Chinese herbal medicine (CHM) plus human chorionic gonadotropin and progesterone, and 18 patiens in the control group were treated with multi-vitamin only. The change of anticardiolipin antibody was determined by enzyme linked immunoabsorbent assay (ELISA).


RESULTS
After treatment, anticardiolipin antibody negative converted in 20 cases (86.9%) of the treated group. The cure rate of abortion in the treated group was 82.6% (19/23), which was raised to 95% (19/20) in those patients with antibody negative conversion, while in the control group, it was 16.7% (3/18) merely, comparison between the two groups in cure rate showed significant difference (P < 0.01).


CONCLUSIONS
CHM plus human chorionic gonadotropin and progesterone could cure AARSA effectively.
Shu
Jing
J
First Hospital of Ningbo City, Zhejiang 315010.
Miao
Pin
P
Wang
Ruo-jie
RJ
D000026:Abortion, Habitual / Q000276:immunology* / Q000517:prevention & control; D000022:Abortion, Spontaneous / Q000276:immunology / Q000517:prevention & control; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008517:Phytotherapy; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000627:therapeutic use*
D017153:Antibodies, Anticardiolipin; D006063:Chorionic Gonadotropin; D004365:Drugs, Chinese Herbal; D011374:Progesterone