[Cardiac-hemodynamic effects of M3 receptor agonist on rat and rabbit hearts].
OBJECTIVE
To study the activation of choline on M3-R in heart and observe the hemodynamic changes of rat and rabbit.


METHODS
A cardiac catheter was inserted into the left ventricular cavity via the right carotid artery, then the HR, LVSP, LVEDP, and +/- dp/dt were measured using a polygraph system.


RESULTS
Choline was shown to decrease the hemodynamic assessments, such as HR, + dp/dt, LVSP and LVEDP. while the M3-R antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) showed little effect on these assessments. It was found to reverse the hemodynamic effects of choline.


CONCLUSIONS
M3 receptor agonist can produce negative inotropic and chronotropic effects on the heart of rat and rabbit.
Liu
Y
Y
Department of Pharmacology, Harbin Medical University, Harbin 150086, China.
Wang
Y
Y
Ma
M L
ML
Zhang
Y
Y
Li
H W
HW
Chen
Q W
QW
Yang
B F
BF
D000818:Animals; D002794:Choline / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D018721:Muscarinic Agonists / Q000494:pharmacology*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010880:Piperidines; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D043587:Receptor, Muscarinic M3; D011976:Receptors, Muscarinic / Q000502:physiology*
D018721:Muscarinic Agonists; D018727:Muscarinic Antagonists; D010880:Piperidines; D043587:Receptor, Muscarinic M3; D011976:Receptors, Muscarinic; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; D002794:Choline