Identification and characterization of the gerH operon of Bacillus anthracis endospores: a differential role for purine nucleosides in germination.
We identified a tri-cistronic operon, gerH, in Bacillus anthracis that is important for endospore germination triggered by two distinct germination response pathways termed inosine-His and purine-Ala. Together, the two pathways allow B. anthracis endospores a broader recognition of purines and amino acids that may be important for host-mediated germination.
Weiner
Matthew A
MA
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48104, USA.
Read
Timothy D
TD
Hanna
Philip C
PC
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D001408:Bacillus anthracis / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D007288:Inosine / Q000494:pharmacology; D009876:Operon; D011684:Purine Nucleosides / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000235:genetics / Q000502:physiology
D000596:Amino Acids; D001426:Bacterial Proteins; D011684:Purine Nucleosides; D007288:Inosine; D000409:Alanine