Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.
OBJECTIVE
To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).


METHODS
Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.


RESULTS
There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival.


CONCLUSIONS
The APOEepsilon4 allele in this population may be associated with poor survival following ICH.
McCarron
M O
MO
Department of Neurology, Royal Victoria Hospital, Belfast, UK. mark.mccarron@royalhospitals.n-i.nhs.uk
Weir
C J
CJ
Muir
K W
KW
Hoffmann
K L
KL
Graffagnino
C
C
Nicoll
J A R
JA
Lees
K R
KR
Alberts
M J
MJ
D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000235:genetics* / Q000401:mortality*; D005260:Female; D005838:Genotype; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D044469:Racial Groups; D017678:Sex Distribution; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
D053327:Apolipoprotein E4; D001057:Apolipoproteins E