title: Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejection.
abstract: BACKGROUND
  Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period.
  
  
  METHODS
  We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection.
  
  
  RESULTS
  Receiver operating characteristic curves demonstrated that on posttransplantation days 3 to 5, sCD30 allowed a differentiation of recipients who subsequently developed acute allograft rejection (n=25) from recipients with an uncomplicated course (n=20, P<0.0001) (area under the receiver operating characteristic curve 0.96, specificity 100%, sensitivity 88%) and recipients with acute tubular necrosis in the absence of rejection (n=11, P=0.001) (area under the receiver operating characteristic curve 0.85, specificity 91%, sensitivity 72%).
  
  
  CONCLUSIONS
  sCD30 measured on posttransplantation days 3 to 5 offers a noninvasive means for differentiating patients with impending acute allograft rejection from patients with an uncomplicated course or with acute tubular necrosis.
authors.affiliation: Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Pelzl
authors.forename: Gerhard
authors.initials: G
authors.lastname: Opelz
authors.forename: Volker
authors.initials: V
authors.lastname: Daniel
authors.forename: Manfred
authors.initials: M
authors.lastname: Wiesel
authors.forename: Caner
authors.initials: C
authors.lastname: Süsal
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers; D005069:Evaluation Studies as Topic; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012995:Solubility; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen