title: Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring.
abstract: Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects of such 'programming' on the vascular function of female offspring when they in turn become pregnant. We have therefore studied isolated conduit and resistance artery function from pregnant female offspring of control (C, 18 % casein) and protein-restricted (PR, 9 % casein) pregnant dams. There were no differences in birth weight, weight gain during pregnancy, litter size, fetal weight, placental weight, fetal : placental weight ratio or organ weights between the C and PR groups. In isolated mesenteric arteries, the vasodilatation in response to the endothelial-dependent vasodilator acetylcholine (ACh) and the beta-adrenoceptor agonist isoprenaline was decreased in the PR group, while there were no differences in the constriction in response to potassium (125 mM) or the alpha1-adrenoceptor agonist phenylephrine (PE). No differences in any responses were seen in the isolated thoracic aorta. We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries.
authors.affiliation: Centre for Fetal Origins of Adult Disease, University of Southampton, Southampton, SO16 5YA, UK. c.torrens@soton.ac.uk
authors.forename: Christopher
authors.initials: C
authors.lastname: Torrens
authors.forename: Lee
authors.initials: L
authors.lastname: Brawley
authors.forename: Alison C
authors.initials: AC
authors.lastname: Barker
authors.forename: Shigeru
authors.initials: S
authors.lastname: Itoh
authors.forename: Lucilla
authors.initials: L
authors.lastname: Poston
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hanson
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D004044:Dietary Proteins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008098:Litter Size / Q000502:physiology; D008297:Male; D008638:Mesenteric Arteries / Q000502:physiology; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology*; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*; D051381:Rats; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000318:Adrenergic beta-Agonists; D004044:Dietary Proteins; D014665:Vasodilator Agents; D007545:Isoproterenol; D000109:Acetylcholine