[Study on effect of nephropathy mixture on genetic expression of liver albumin in rats with adriamycin-induced nephrotic syndrome].
OBJECTIVE
To explore the effect of Nephropathy mixture on genetic expression of liver albunin in rats with adriamycin-induced nephrotic syndrome.


METHODS
The rat model of adriamycin-induced nephrotic syndrome was established and the liver albumin mRNA expression level was observed with Northern hybridization and Dot-blot quantitative analysis.


RESULTS
The liver albumin mRNA expression level in the Nephropathy Mixture treated group was significantly higher than that in the model group and the normal control group (P < 0.05).


CONCLUSIONS
Nephropathy Mixture could up-regulate the liver albumin mRNA expression level and promote the synthesis of albumin in rats with adriamycin-induced nephrotic syndrome.
Li
X M
XM
Department of Pediatrics, First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193.
Ma
R
R
Lu
B
B
D000418:Albumins / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D004317:Doxorubicin; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D000418:Albumins; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D004317:Doxorubicin