Comparison of a novel liquid (Adcon-P) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) in postsurgical adhesion formation in a murine model.
OBJECTIVE
Intra-abdominal administration of antiadhesive barriers may reduce the extent and severity of postoperative adhesions. This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm) antiadhesive barrier in a murine cecal abrasion model.


METHODS
One hundred fifty Swiss-Wister mice underwent laparotomy and cecal abrasion and were randomly assigned to receive Adcon-P (n = 30) or Seprafilm (n = 30) or to a control group (n = 90). At postoperative Day 21, the mice underwent relaparotomy and complete adhesiolysis. An investigator who was blinded to the group assignment scored the extent of adhesion formation and the difficulty of adhesiolysis using a 6-point scale that ranged from 0 (no adhesions) to 5 (full-thickness intestinal injury with adhesiolysis). Results are reported as median (range).


RESULTS
Median adhesion scores in mice receiving Adcon-P (0 (range, 0-1)) and Seprafilm (1 (range, 0-3)) were lower than in mice in the control group (2 (range, 0-5); P < 0.0001 for both comparisons). In addition, the median adhesion score for the Adcon-P group was significantly lower than that of the Seprafilm group (P = 0.02).


CONCLUSIONS
This study suggests that both Adcon-P and Seprafilm trade mark decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However, Adcon-P appeared to be superior to Seprafilm. This agent is an attractive device that requires additional studies.
Oncel
Mustafa
M
Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Remzi
Feza H
FH
Senagore
Anthony J
AJ
Connor
Jason T
JT
Fazio
Victor W
VW
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium; D005782:Gels; D006820:Hyaluronic Acid; D007410:Intestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D007421:Intestine, Small / Q000601:surgery; D007813:Laparotomy / Q000009:adverse effects; D008567:Membranes, Artificial; D051379:Mice; D023421:Models, Animal; D009930:Organic Chemicals; D011183:Postoperative Complications / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control; D016896:Treatment Outcome
C472115:Adcon-P; D001672:Biocompatible Materials; D005782:Gels; D008567:Membranes, Artificial; D009930:Organic Chemicals; C118198:Seprafilm; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium