title: Impact of posterior GPI pallidotomy on leg tremor in Parkinson's disease.
abstract: Although stereotactic thalamotomy is the mainstay in the surgical treatment of tremor in patients with Parkinson's disease (PD), this surgery is not favored and is even a matter of potential concern in the treatment of leg tremor since it carries a significant risk of injury to the internal capsule. In this study we have carried out a quantitative assessment of leg tremor alleviation in 12 patients with PD after MRI-/microelectrode-guided stereotactic ablation of the posterior part of the globus pallidus internus (GPi). The results showed that posterior GPi pallidotomy combined with drug therapy is a satisfactorily effective therapeutic strategy to treat parkinsonian leg tremor.
authors.affiliation: Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan. sgoto@kaiju.medic.kumamoto-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goto
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Mita
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ushio
mesh_terms: D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007866:Leg / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D038361:Neuronavigation / Q000379:methods; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D014202:Tremor / Q000503:physiopathology / Q000601:surgery*