First direct reductive amination of mucochloric acid: a simple and efficient method for preparing highly functionalized alpha,beta-unsaturated gamma-butyrolactams.
[reaction: see text] The first direct reductive amination of mucochloric acid (1) has been accomplished. Reaction of 1 with various alkyl, aryl, and benzylamines, followed by reduction in the same pot, provides an efficient method of obtaining N-benzyl-3,4-dichloro-1,5-dihydro-pyrrol-2-one and N-aryl (or alkyl)-3,4-dichloro-1,5-dihydro-pyrrol-2-ones.
Zhang
Ji
J
Chemical Research and Development, Pfizer Global Research & Development, Ann Arbor Laboratories, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. ji.zhang@pfizer.com
Blazecka
Peter G
PG
Davidson
James G
JG
D000586:Amination; D015195:Drug Design; D005663:Furans / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry; D047090:beta-Lactams / Q000138:chemical synthesis*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
D005663:Furans; D011759:Pyrrolidines; D047090:beta-Lactams; D005680:gamma-Aminobutyric Acid; C014117:mucochloric acid