[Study of xixin, duzhong and mixture to the antioxidant system of D-galactose-induced senile mice].
D-galactose induced mice aging model were used in this experiment. This study investigated the effect of the herb on the activity of superoxide dismutase(SOD), glutahione peroxidase (GSH-Px) and NOS, in order to know the damages degree of body by free radical and determine the changes of above index after giving Duzhong, Xixin and their Mixture 15, 30 and 45 days, at the same time, the mechanism of their effect on antiaging was probed. The results were as follows: The activity of SOD, GSH-Px and NOS was increasing before middel age and decreasing after middelage(P < 0.01); Xixin and Duzhong could enhance the activity of SOD, GSH-Px and NOS; The time of effect for mixture and Duzhong to above index was short than Xixin's. The time of Mixture and Duzhong was 15 days, and Xixin was 30 days.
Li
K
K
Jiamusi Medical College, Heilongjiang 154002.
Liu
M
M
Wei
X
X
D000375:Aging / Q000378:metabolism*; D000818:Animals; D030023:Asarum / Q000737:chemistry*; D001921:Brain / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D031283:Eucommiaceae / Q000737:chemistry*; D005260:Female; D005690:Galactose; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D051379:Mice; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I; D010946:Plants, Medicinal / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005979:Glutathione Peroxidase; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496321:Nos1 protein, mouse; D013482:Superoxide Dismutase; D005690:Galactose