title: Experimental treatment of complications in alloxan diabetic rats with alpha-glucosidase inhibitor from the Chinese medicinal herb ramulus mori.
abstract: OBJECTIVE
  To assess the effects of the alpha-glucosidase inhibitor Sangzhi (Ramulus mori, SZ) on the relief of diabetic symptoms of hyperglycemia and the prevention of its late complications in alloxan diabetic rats with high-calorie chow.
  
  
  METHODS
  The aqueous extract of Sangzhi was given orally to alloxan diabetic rats for 15 days. The hyperglycemic symptoms were observed. The blood glucose, lipid levels and the nephrotic representations were measured.
  
  
  RESULTS
  When alloxan diabetic rats on high-calorie chow were treated with SZ, the hyperglycemic symptoms were improved, the blood lipid levels were improved, the ratio of kidney over body weight and the blood N-acetyl-beta-D-glucosaminidase (NAG) activity were lowered. The degree of renal pathological changes was significantly reduced.
  
  
  CONCLUSIONS
  SZ may be useful for treating diabetes and its complications.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Zhu-fang
authors.initials: ZF
authors.lastname: Shen
authors.forename: Feng-xia
authors.initials: FX
authors.lastname: Qiao
authors.forename: De-yu
authors.initials: DY
authors.lastname: Zhao
authors.forename: Ming-zhi
authors.initials: MZ
authors.lastname: Xie
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008297:Male; D031625:Morus / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D000520:alpha-Glucosidases / Q000302:isolation & purification
chemical_list: D001786:Blood Glucose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D014280:Triglycerides; D000520:alpha-Glucosidases; D000118:Acetylglucosaminidase