title: Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs.
abstract: Speed of kill and percentage kill of nitenpyram (CAPSTAR) was compared to fipronil (Frontline) spot-on), imidacloprid (Bayvantage/Advantage), selamectin (Stronghold/Revolution) and cythioate (Cyflee) against adult fleas on cats and dogs 3 and 8h post-treatment. Selamectin was used on dogs only; cythioate was used on cats only. Groups of eight cats and eight dogs (four males and four females each) were experimentally infested with 100 unfed fleas 1 day prior to treatment with the test products. One group of cats and one group of dogs served as control. Fleas were collected from four cats and four dogs in each group (two males and two females) by combing 3h after treatment, the remaining four cats or dogs were combed 8h after treatment. In cats cythioate treatment resulted in a mean efficacy of 62.4 and 97.4% at 3 and 8h post-treatment, respectively. Imidacloprid efficacy at the same times was 26.9 and 82.8%, whereas fipronil efficacy was 24.3 and 62.6% efficacy, respectively. In dogs mean efficacy 3 and 8h after treatment with selamectin was 39.7 and 74.4%; with imidacloprid efficacy was 22.2 and 95.7%, respectively and 35.9 and 46.5%, respectively after treatment with fipronil. Nitenpyram was 100% effective in cats and 99.1% effective in dogs within 3h of treatment and 100% effective in cats and dogs within 8h.
authors.affiliation: Novartis Animal Health Inc., CH-4002, Basel, Switzerland. rudolf.shenker@ah.novartis.com
authors.forename: R
authors.initials: R
authors.lastname: Schenker
authors.forename: O
authors.initials: O
authors.lastname: Tinembart
authors.forename: E
authors.initials: E
authors.lastname: Humbert-Droz
authors.forename: T
authors.initials: T
authors.lastname: Cavaliero
authors.forename: B
authors.initials: B
authors.lastname: Yerly
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004478:Ectoparasitic Infestations / Q000188:drug therapy* / Q000662:veterinary*; D005260:Female; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D007306:Insecticides / Q000494:pharmacology / Q000627:therapeutic use*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use; D005423:Siphonaptera / Q000187:drug effects*; D013997:Time Factors
chemical_list: D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011720:Pyrazoles; D011725:Pyridines; C464843:nitenpyram; C082359:imidacloprid; D007559:Ivermectin; C414354:selamectin; C082360:fipronil