title: QSARs for identifying and prioritizing substances with persistence and bioconcentration potential.
abstract: From the 8511 chemicals with 1998 production volumes reported to the U.S. Environmental Protection Agency (U.S. EPA), the TSCA Interagency Testing Committee's (ITC's) Degradation Effects Bioconcentration Information Testing Strategies (DEBITS) was used to identify 56 chemicals. The DEBITS Quantitative Structure-Activity Relationships (QSARs) and the U.S. EPA's PBT profiler QSARs were used to predict the persistence and bioconcentration factors of these 56 chemicals. Partial order ranking was used to prioritise the chemicals based on persistence and bioconcentration potential.
authors.affiliation: TSCA Interagency Testing Committee (ITC), U.S. Environmental Protection Agency (7401M), 1200 Pennsylvania Avenue, NW Washington, DC 20460, USA. walker.johnd@epa.gov
authors.forename: J D
authors.initials: JD
authors.lastname: Walker
authors.forename: L
authors.initials: L
authors.lastname: Carlsen
mesh_terms: D001682:Biological Availability; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000493:pharmacokinetics*; D008962:Models, Theoretical; D012016:Reference Values; D018570:Risk Assessment; D013329:Structure-Activity Relationship; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D004785:Environmental Pollutants