title: Diversity of signaling controls of macroautophagy in mammalian cells.
abstract: Macroautophagy is a major lysosomal catabolic process conserved from yeast to human. The formation of autophagic vacuoles is stimulated by a variety of intracellular and extracellular stress situations including amino acid starvation, aggregation of misfolded proteins, and accumulation of damaged organelles. Several signaling pathways control the formation of autophagic vacuoles. As some of them are engaged in the control of protein synthesis or cell survival this suggests that macroautophagy is intimately associated with the execution of cell proliferation and cell death programs. Whether or not these different signaling pathways converge to a unique point to trigger the formation of autophagic vacuole remains an open question.
authors.affiliation: Department of Biochemistry, University of Geneva, Science II, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland.
authors.forename: Anne
authors.initials: A
authors.lastname: Petiot
authors.forename: Sophie
authors.initials: S
authors.lastname: Pattingre
authors.forename: Sébastien
authors.initials: S
authors.lastname: Arico
authors.forename: Daniel
authors.initials: D
authors.lastname: Meley
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D004798:Enzymes / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology* / Q000648:ultrastructure; D006801:Humans; D008247:Lysosomes / Q000201:enzymology / Q000648:ultrastructure; D008322:Mammals / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000378:metabolism; D014617:Vacuoles / Q000201:enzymology* / Q000648:ultrastructure
chemical_list: D004798:Enzymes