[Anti-injure effect of extract from orange (EOP) peel on germ cells of male mice].
In present study, the anti-injure effect of EOP, on incidence of sperm abnormality and meiotic micronuclei of early spermatids in mice induced by cyclophosphamide was investigated. The results indicated that EOP itself was not a mutagen, but significantly inhibited increase of the rate of micronuclei and the sperm abnormality by CP. The rates of sperm abnormality and meiotic micronuclei of early spermatide of EOP before CP using group were lower obviously than those of CP could before EOP using group (P < 0.01). The results suggested that the CP could permeate blood-testis barrier into germ cells of male mice and induced mutation on genetic material.
Liu
Q
Q
Department of Biological Science and Technology, Nanjiang University, Nanjing 210093.
Jiao
Q
Q
Liu
T
T
D000818:Animals; D032084:Citrus sinensis / Q000737:chemistry*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013087:Spermatids / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D010936:Plant Extracts; D003520:Cyclophosphamide