title: The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study.
abstract: BACKGROUND
  Several studies in patient populations have reported a positive association between alcohol consumption and serum total IgE. Furthermore, we have previously reported a positive association between alcohol consumption and the prevalence of skin prick test (SPT positivity) to inhalant allergens in a population-based cross-sectional study.
  
  
  OBJECTIVE
  To investigate the relationship of alcohol consumption to levels of serum total IgE and the development of IgE sensitization to inhalant allergens.
  
  
  METHODS
  In 1990, self-reported consumption of alcohol, serum total IgE, SPT positivity and specific IgE positivity to inhalant allergens were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Copenhagen, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using multivariable regression analyses.
  
  
  RESULTS
  In non-atopic (specific IgE negative) subjects there was a positive association between alcohol consumption and the concentration of total IgE (P = 0.001). During the follow-up period, 45 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. There was no significant association between alcohol consumption and the development of SPT positivity or specific IgE positivity. However, the risk of developing SPT positivity tended to increase with increasing consumption of alcohol (P = 0.055).
  
  
  CONCLUSIONS
  This epidemiological study confirms that alcohol consumption has an influence on levels of serum total IgE. A significant association between alcohol consumption and the development of IgE sensitization was not established. However, there seems to be a lack epidemiological data on this issue.
authors.affiliation: Centre for Preventive Medicine, Glostrup University Hospital, Glostrup, Denmark. linneberg@dadlnet.dk
authors.forename: A
authors.initials: A
authors.lastname: Linneberg
authors.forename: J
authors.initials: J
authors.lastname: Petersen
authors.forename: N H
authors.initials: NH
authors.lastname: Nielsen
authors.forename: F
authors.initials: F
authors.lastname: Madsen
authors.forename: L
authors.initials: L
authors.lastname: Frølund
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: T
authors.initials: T
authors.lastname: Jørgensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D000485:Allergens / Q000276:immunology*; D000431:Ethanol / Q000008:administration & dosage / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D016014:Linear Models; D008875:Middle Aged; D016017:Odds Ratio; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D000431:Ethanol