Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats.
Vinyl acetate monomer (VAM) was administered in drinking water supplied ad libitum at doses of 5,000, 1,000, and 0 ppm (v/v) to 17-week-old Sprague-Dawley rats (breeders) and to 12-day embryos (offspring). Treatment lasted for 104 weeks; thereafter, animals were kept under control conditions until spontaneous death. VAM was found to cause an increase in total malignant tumors and in carcinomas and/or precursor lesions of the oral cavity, lips, tongue, esophagus, and forestomach. Based on these data, VAM must be considered a multipotent carcinogen.
Minardi
Franco
F
Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy.
Belpoggi
Fiorella
F
Soffritti
Morando
M
Ciliberti
Adriano
A
Lauriola
Michelina
M
Cattin
Elisa
E
Maltoni
Cesare
C
D000818:Animals; D001681:Biological Assay / Q000379:methods; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000145:classification / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014753:Vinyl Compounds / Q000633:toxicity*
D002273:Carcinogens; D014753:Vinyl Compounds; C011566:vinyl acetate