title: Prediction of visual outcome after penetrating keratoplasty for pseudophakic corneal edema.
abstract: OBJECTIVE
  To evaluate the ability to predict visual outcome after penetrating keratoplasty (PKP) in patients with pseudophakic corneal edema (PCE) or aphakic corneal edema (ACE) based on preoperative parameters available from the patient history and ocular examination.
  
  
  METHODS
  Retrospective noncomparative case series.
  
  
  METHODS
  Forty-eight patients who underwent 59 PKP procedures for PCE between 1997 and 2000 by two cornea specialists.
  
  
  METHODS
  Medical records were retrospectively analyzed for variables in the history and ocular examination before PKP and visual outcome after PKP. Variables included age, gender, presence of diabetes or cardiovascular disease, method of intraocular lens (IOL) implantation during cataract surgery, vitreous loss during cataract surgery, time between cataract and PKP surgery, and maximal visual acuity reached after cataract surgery. The predictive value of each preoperative variable on post-PKP visual outcome was assessed using both univariate and multiple regression analyses.
  
  
  METHODS
  Statistical significance for the predictive value of each preoperative variable on post-PKP visual outcome.
  
  
  RESULTS
  Best-corrected visual acuity (BCVA) of 20/40 or better was achieved in 13 patients (27%). The strongest predictor of this outcome was implantation of a bag-fixated or sulcus-fixated IOL at the time of cataract surgery (P = 0.007; odds ratio, 15.8; 95% confidence interval, 1.2-208). Less significant variables included BCVA after cataract surgery, time between cataract surgery and PKP, and gender.
  
  
  CONCLUSIONS
  In planning and advising patients with pseudophakic or aphakic corneal edema who are candidates for PKP, the method of IOL implantation during the cataract surgery is the single most significant predictor of visual acuity after corneal transplantation. Bag-fixated or sulcus-fixated posterior chamber IOL was associated with a better visual outcome than anterior chamber IOL, scleral-fixated posterior chamber IOL, or aphakia.
authors.affiliation: Department of Ophthalmology, Assaf Harofe Medical Center, Beer Yaacov, Zerifin 70300 Israel.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Barkana
authors.forename: Ori
authors.initials: O
authors.lastname: Segal
authors.forename: David
authors.initials: D
authors.lastname: Krakovski
authors.forename: Issac
authors.initials: I
authors.lastname: Avni
authors.forename: David
authors.initials: D
authors.lastname: Zadok
mesh_terms: D000368:Aged; D001036:Aphakia, Postcataract / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D015715:Corneal Edema / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D019591:Pseudophakia / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*