title: Delayed ossification of the proximal capital femoral epiphysis in Legg-Calvé-Perthes' disease.
abstract: We studied radiographs of 125 children (105 boys, 20 girls) with unilateral Legg-Calvé-Perthes' disease to examine the epiphyseal development of the femoral head in the contralateral (unaffected) hip. The epiphyseal height (EH) and width (EW) of the unaffected hip were measured on the initial anteroposterior pelvic radiograph. In 109 of the patients (87.2%) the EH was below the mean for normal Japanese children and a significantly small EH (below -2 SDs) was observed in 23 patients (18.4%). By contrast, the EW of most patients (95.2%) lay within +/- 2 SDs of normal values except for six with a significantly small EW. A strong positive linear correlation (R = 0.87) was observed in the EH:EW ratio in the patients. A smaller EH than expected for EW in our series indicated epiphyseal flattening of the femoral head in Legg-Calvé-Perthes' disease. Our findings support the hypothesis that a delay in endochondral ossification in the proximal capital femoral epiphysis may be associated with the onset of Perthes' disease.
authors.affiliation: Department of Orthopaedic Surgery, Nagoya University School of Medicine, Aichi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kitoh
authors.forename: T
authors.initials: T
authors.lastname: Kitakoji
authors.forename: M
authors.initials: M
authors.lastname: Katoh
authors.forename: Y
authors.initials: Y
authors.lastname: Takamine
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004838:Epiphyses / Q000254:growth & development; D005260:Female; D005270:Femur Head / Q000254:growth & development*; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000503:physiopathology*; D008297:Male; D010012:Osteogenesis / Q000502:physiology*