title: [Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report].
abstract: We report the case of a 78 years old female patient with primary restless legs syndrome (RLS) with an autosomal dominant pattern of inheritance. In addition, the patient also had depression. We emphasize the worsening of symptoms of RLS after the use of a selective serotonin uptake inhibitor (mirtazapine), with improvement after the drug was discontinued, and an excellent recovery with the use of low dose dopaminergic agonist (pramipexol).
authors.affiliation: Serviço de Neurologia, Departamento de Clínica Médica, Hospital de Clínicas, Universidade Federal de Paraná, Curitiba, PR, Brasil. hagtevive@mps.com.br
authors.forename: Hélio A G
authors.initials: HA
authors.lastname: Teive
authors.forename: Aníbal
authors.initials: A
authors.lastname: de Quadros
authors.forename: Felipe Cabral
authors.initials: FC
authors.lastname: Barros
authors.forename: Lineu César
authors.initials: LC
authors.lastname: Werneck
mesh_terms: D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008803:Mianserin / Q000009:adverse effects* / Q000031:analogs & derivatives; D000078785:Mirtazapine; D010375:Pedigree; D012148:Restless Legs Syndrome / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine