[Congestive heart failure and paraoxonase].
OBJECTIVE
To determine the changes of paraoxonase activity in patients with heart failure.


METHODS
The serum paraoxonase (PON) activity of the heart failure group and controls was measured with phenylacetate as the substrate.


RESULTS
The serum PON activity of the heart failure patients significantly decreased as compared with the controls; after the treatment, the PON activity of heart failure was largely elevated; and the PON activity of the patients with heart failure was negatively correlated with tumor necrosis factor-alpha.


CONCLUSIONS
The PON activity of patients with congestive heart failure significantly decreases.
Xie
Xiao-mei
XM
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhao
Shui-ping
SP
D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase; D004070:Digitalis / Q000187:drug effects; D004950:Esterases / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D004950:Esterases; D043303:Aryldialkylphosphatase