[Experimental study on the viricidal effect of rough extracts of camptothecine fruit on herpes simplex virus-2 in vitro].
OBJECTIVE
To study the viricidal effect of rough extracts of camptothecine fruit on herpes simplex virus-2 (HSV-2).


METHODS
Rough extracts with different concentrations were mixed with HSV-2. The mixture was incubated at 37 degrees C for 4 h or at 4 degrees C overnight, adsorbed on monolayer cells of BGM for 1.5 h, and cultured at 37 degrees C for 7 d.


RESULTS
The BGM of the test group did not reveal cytopathic effects (CPE), while the control group showed CPE under microscope observation.


CONCLUSIONS
Camptothecine has a strong viricidal effect on HSV-2.
Li
Wen-wen
WW
Department of Clinical Microbiology and Immunology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Yan
Zu-wei
ZW
Shi
Kai
K
D000998:Antiviral Agents / Q000494:pharmacology*; D029769:Camptotheca / Q000737:chemistry*; D002166:Camptothecin / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology
D000998:Antiviral Agents; D010936:Plant Extracts; D002166:Camptothecin