title: O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans.
abstract: Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4'-sulfate. C. elegans also converted 5, 3', 4'-trihydroxy-7-methoxyflavanone into eriodictyol-4'-sulfate. Furthermore, incubation of 5, 4'-dihydroxy-7, 3'-dimethoxyflavanone with the same fungus gave homoeriodictyol (5, 7, 4'-trihydroxy-3'-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.
authors.affiliation: Pharmacognosy Departments, College of Pharmacy, Tanta University, Japan. arsib16@hotmail.com
authors.forename: Abdel-Rahim Sayed
authors.initials: AR
authors.lastname: Ibrahim
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: Galal
authors.forename: Mohammed Shamim
authors.initials: MS
authors.lastname: Ahmed
authors.forename: Gabir Salem
authors.initials: GS
authors.lastname: Mossa
mesh_terms: D020093:Cunninghamella / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D010090:Oxidoreductases, O-Demethylating / Q000737:chemistry / Q000378:metabolism; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism; D000094162:Phytoalexins
chemical_list: D005419:Flavonoids; D010090:Oxidoreductases, O-Demethylating; D013440:Sulfides; C099724:sakuranetin; D000094162:Phytoalexins