title: Obstetric predictors of placental/umbilical cord blood volume for transplantation.
abstract: OBJECTIVE
  Umbilical cord blood is an effective alternative to bone marrow as a source of hematopoietic stem cells in transplantation. However, the amount of donor blood and the cell content that are collected may be insufficient for engraftment in some adult recipients. This study identifies obstetric factors that affect retrievable placental cord blood volume.
  
  
  METHODS
  A retrospective analysis of factors that were obtained by direct observation or medical record review that were related to harvested cord blood volume was conducted; the analysis involved 9205 deliveries from mothers who donated placental cord blood through the obstetric services of two New York City hospitals between 1993 and 1999.
  
  
  RESULTS
  Obstetric factors that influenced significantly the total volume of blood that was collected were route of delivery, induction of labor, presence of a nuchal cord, infant birth weight, multiple births, placental weight, and duration of labor. The length of the umbilical cord from the venipuncture site and the length of time to cord blood collection also affected the volume that was retrieved. Maternal ethnicity was associated with cord blood yield; Caucasian mothers provided larger quantities than either African American or Asian mothers.
  
  
  CONCLUSIONS
  Our results confirm that the volume of residual placental cord blood that is collected for hematopoietic stem cell transplantation is influenced by several factors, the presence of which predict the likelihood of an adequate collection. Collected volumes can be improved when a longer length of the cord is left with the placenta and when there is a shorter time between the delivery of the placenta and the collection.
authors.affiliation: Department of Obstetrics and Gynecology, Brooklyn Hospital Center, New York, USA.
authors.forename: Johannes
authors.initials: J
authors.lastname: Jones
authors.forename: Cladd E
authors.initials: CE
authors.lastname: Stevens
authors.forename: Pablo
authors.initials: P
authors.lastname: Rubinstein
authors.forename: Robert R
authors.initials: RR
authors.lastname: Robertazzi
authors.forename: Angela
authors.initials: A
authors.lastname: Kerr
authors.forename: Michael F
authors.initials: MF
authors.lastname: Cabbad
mesh_terms: D001810:Blood Volume; D036861:Delivery, Obstetric; D005260:Female; D005544:Forecasting; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010920:Placenta / Q000098:blood supply*; D044469:Racial Groups; D012189:Retrospective Studies; D013997:Time Factors; D014470:Umbilical Cord / Q000098:blood supply*