Myocardial angiogenesis resulting in functional communications with the left cavity induced by intramyocardial high-frequency ablation: histomorphology of immediate and long-term effects in pigs.
A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.
Dietz
Ulrich
U
German Clinic for Diagnostics, Wiesbaden, Germany. dietz.kardio@dkd-weisbaden.de
Horstick
Georg
G
Manke
Tobias
T
Otto
Mike
M
Eick
Olaf
O
Kirkpatrick
C James
CJ
Meyer
Jürgen
J
Darius
Harald
H
D000818:Animals; D017115:Catheter Ablation; D003326:Coronary Circulation; D005240:Feasibility Studies; D017202:Myocardial Ischemia / Q000601:surgery*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D018919:Neovascularization, Physiologic; D013552:Swine