title: [Effects of combined transdermal acupoint electric stimulation and isoflurane anesthesia on isoflurane-induced hypotension and tissue oxygen metabolism in patients undergoing craniotomy].
abstract: OBJECTIVE
  To observe the effects of combined transdermal acupoint electric stimulation and isoflurane anesthesia on isoflurane-induced hypotension and tissue oxygen metabolism in patients undergoing craniotomy.
  
  
  METHODS
  Forty-two patients with brain tumor of ASA physical status I or II and scheduled for elective surgery were randomly divided into two groups. The craniotomy was undergoing in Group A with isoflurane anesthesia, while in Group B, with combined transdermal acupoint electric stimulation (TAES) and isoflurane anesthesia. Isoflurane induced hypotension was performed in both groups by augmenting the concentration of isoflurane to lower the mean arterial pressure than before anesthesia for 30%-40% and maintain for 30-45 mins. The tissue oxygen metabolism, blood gas and arterial lactic acid level before, during and after hypotension were monitored by Swan-Ganz floating catheterization.
  
  
  RESULTS
  As compared with before hypotension, the pulmonary arterial and mixed with venous blood oxygen saturation lowered and oxygen supply lowered, and oxygen uptake increased significantly in both groups (P < 0.05), but the extent of changes in oxygen metabolic criteria in Group B were all lesser than those in Group A (P < 0.05).
  
  
  CONCLUSIONS
  Combined acupoint electric stimulation and general anesthesia could maintain the tissue oxygen supply and demand balance better in the isofluraneinduced hypotension process.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, Zhejiang 325000.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.forename: W X
authors.initials: WX
authors.lastname: Xie
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D018685:Anesthetics, Inhalation; D003399:Craniotomy; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D007530:Isoflurane; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000601:surgery; D008579:Meningioma / Q000378:metabolism / Q000601:surgery; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane; D010100:Oxygen