[Clinical and experimental study on treatment of childhood hyperkinetic syndrome with yizhidan].
OBJECTIVE
To observe the clinical effect of Yizhidan (YZD) in treating childhood hyperkinetic syndrome (CHS) and its mechanism.


METHODS
Random single blind method was used in clinical study to observe the clinical effect of YZD and compared with that of Ritalin. The dysmnesia model animal was used to observe the effect of YZD on learning memory function and cerebral monoamine neurotransmitter content.


RESULTS
The markedly effective rate and the total effective rate of YZD were 45.56% and 87.78%, which were similar to those of Ritalin (53.33% and 86.67%). The Conners index lowered in both groups, showing insignificant difference (P > 0.05). Experimental observation showed that YZD could significantly improve the soft neurologic signs and abnormal encephalogram with less side-effects in comparing with Ritalin (P < 0.05). Moreover, YZD could obviously improve the learning memory disturbance induced by scopolamine, sodium nitrite and ethanol, and significantly increased the contents of DA in cerebral tissue, as compared with that of the control group, the difference was significant (P < 0.01). It also showed effect on DOPAC, NE, HVA, 5-HT and 5-HIAA of mice in certain degree.


CONCLUSIONS
YZD is an effective drug in treating CHS, its mechanism might be probably related to the improvement of the memory and the enhancement of DA receptor in cerebral tissue.
Chen
Y H
YH
Henan College of TCM, Zhengzhou 450003.
Huang
B
B
Zhao
X
X
D018663:Adrenergic Agents / Q000627:therapeutic use; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001921:Brain / Q000378:metabolism; D002648:Child; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D051379:Mice; D008517:Phytotherapy; D016037:Single-Blind Method
D018663:Adrenergic Agents; D004365:Drugs, Chinese Herbal; D008774:Methylphenidate; D004298:Dopamine