title: Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.
abstract: OBJECTIVE
  Underestimation of disease severity is a major problem confronting the successful clinical management of non-small cell lung cancer. Recent advances in molecular biological substaging may provide an opportunity to identify those patients with the most aggressive forms of the disease, but there is a continuing need for accurate markers of disease relapse and survival.
  
  
  METHODS
  In our present study, immunohistochemical analyses of a retrospective database of pathologic specimens were used to demonstrate that the EphA2 receptor kinase is frequently overexpressed in NSCLC.
  
  
  RESULTS
  Initial presentation with high levels of EphA2 predicts subsequent survival, overall relapse, and site of relapse. Specifically, high levels of EphA2 in the primary tumor predict brain metastases, whereas low levels of EphA2 relate to disease-free survival or contralateral lung metastasis.
  
  
  CONCLUSIONS
  These data suggest that EphA2 may provide a molecular marker to identify and predict patients who have isolated brain metastases. Moreover, the high levels of EphA2 in lung cancer may provide an opportunity for therapeutic targeting.
authors.affiliation: MedImmune, Inc., Gaithersburg, Maryland 20878, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kinch
authors.forename: Mary-Beth
authors.initials: MB
authors.lastname: Moore
authors.forename: David H
authors.initials: DH
authors.lastname: Harpole
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D036104:Receptor, EphA2 / Q000378:metabolism*; D012008:Recurrence; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D036104:Receptor, EphA2