title: Deodorants: an experimental provocation study with cinnamic aldehyde.
abstract: BACKGROUND
  Axillary dermatitis is common and overrepresented in individuals with contact allergy to fragrances. Many individuals suspect their deodorants to be the incriminating products.
  
  
  OBJECTIVE
  Our aim was to investigate the significance of cinnamic aldehyde in deodorants for the development of axillary dermatitis when used by individuals with and without contact allergy to cinnamic aldehyde.
  
  
  METHODS
  Patch tests with deodorants and ethanol solutions with cinnamic aldehyde, and repeated open application tests with roll-on deodorants without and with cinnamic aldehyde at different concentrations, were performed in 37 patients with dermatitis, 20 without and 17 with contact allergy to cinnamic aldehyde.
  
  
  RESULTS
  A repeated open application test with positive findings was noted only in patients hypersensitive to cinnamic aldehyde (P <.001) and only in the axilla to which the deodorants containing cinnamic aldehyde had been applied (P <.001).
  
  
  CONCLUSIONS
  Deodorants containing cinnamic aldehyde in the concentration range 0.01% to 0.32%, used twice daily on healthy skin, can elicit axillary dermatitis within a few weeks.
authors.affiliation: Department of Occupational and Environmental Dermatology, University Hospital, Malmö, Sweden. magnus.bruze@derm.mas.lu.se
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: P
authors.initials: P
authors.lastname: Frosch
authors.forename: J-P
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: S
authors.initials: S
authors.lastname: Rastogi
authors.forename: S
authors.initials: S
authors.lastname: Wakelin
authors.forename: I
authors.initials: I
authors.lastname: White
authors.forename: T
authors.initials: T
authors.lastname: Menné
mesh_terms: D000171:Acrolein / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003836:Deodorants / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D005421:Flavoring Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
chemical_list: D003836:Deodorants; D005421:Flavoring Agents; D000171:Acrolein; C012843:cinnamaldehyde