Cutting edge: immediate RANTES secretion by resting memory CD8 T cells following antigenic stimulation.
The efficiency of CD8 memory response relies partially on the modification of cellular functional capacities. To identify effector functions that can be modified following priming, we have compared the chemokines produced by naive and memory CD8 T cells. Our results show that in contrast to naive cells, resting memory CD8 T cells contain high levels of RANTES mRNA. As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-gamma, RANTES secretion is mainly due to the translation of the pre-existing mRNA.
Walzer
Thierry
T
Institut National de la Santé et de la Recherche Médicale, Unité 503, Centre d'Etude et de Recherche en Virologie et Immunologie, 21 avenue Tony Garnier, 69365 Lyon CEDEX 07, France.
Marçais
Antoine
A
Saltel
Frédéric
F
Bella
Chantal
C
Jurdic
Pierre
P
Marvel
Jacqueline
J
D000818:Animals; D000941:Antigens / Q000494:pharmacology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D007156:Immunologic Memory / Q000235:genetics; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D007399:Interphase / Q000235:genetics / Q000276:immunology*; D007700:Kinetics; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010455:Peptides / Q000276:immunology / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000821:virology
D000941:Antigens; D018946:Chemokine CCL5; D010455:Peptides; D012333:RNA, Messenger; D007371:Interferon-gamma