Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs.
Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site; ii) miscellaneous molecules with unknown mechanism(s) of action; iii) inhibitors of upstream processes of regulation of the hTERT subunit; iiii) immunotherapy against immunogenic hTERT-derived peptides.
Richter
Sara
S
Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5 - 35131 Padova, Italy.
Palumbo
Manlio
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007167:Immunotherapy; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D019098:Telomerase