[Study on the permeability of 125I-sinomenine via the transdermal delivery way in rats].
OBJECTIVE
To study the permeance and diffusion trend of 125I-sinomenine via the transdermal delivery way in rats.


METHODS
Assay the permeance depth and diffusion area of sinomenine labeled by isotopic 125I in subcutaneous of rats certain time after sinomenine was administrated on the cervical skin of rats.


RESULTS
The diffuse of sionmenine can reach cervical spine in longitudinal direction and form an area of 2 cm2 in transverse direction. The concentration gradient of both directions are significant.


CONCLUSIONS
125I-sinomenine can not only be absorbed into blood via the transdermal delivery way to have whole effect, but also accumulate large amounts in the skin to have a local effect.
Zhang
Ning
N
ShangHai University of Traditional Chinese Medicine, Shanghai 200032.
Xu
Lianying
L
Xu
Peikang
P
Zhong
Gaoren
G
D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D009019:Morphinans / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032841:Sinomenium / Q000737:chemistry*; D012869:Skin Absorption
D004365:Drugs, Chinese Herbal; D007457:Iodine Radioisotopes; D009019:Morphinans; C009271:sinomenine