Sordaricin antifungal agents.
Compounds based on sordaricin were prepared via organometallic addition onto a fully protected sordaricin aldehyde. The fungal growth inhibition profiles for these compounds were established and the results are presented here. The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement products upon oxidation. These compounds were evaluated as agents to inhibit fungal growth.
Quesnelle
Claude A
CA
Bristol-Myers Squibb Pharmaceutical Research Institute, 100, boul. de l'Industrie, Candiac, Québec, Canada J5R 1J1. claude.quesnelle@bms.com
Gill
Patrice
P
Dodier
Marco
M
St  Laurent
Denis
D
Serrano-Wu
Michael
M
Marinier
Anne
A
Martel
Alain
A
Mazzucco
Charles E
CE
Stickle
Terry M
TM
Barrett
John F
JF
Vyas
Dolatrai M
DM
Balasubramanian
Balu N
BN
D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000478:Alkylation; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes; D005658:Fungi / Q000187:drug effects; D006868:Hydrolysis; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D000447:Aldehydes; D000935:Antifungal Agents; D004224:Diterpenes; D007202:Indicators and Reagents; C116705:sordaricin