Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a variously substituted phenyl ring at N-3 have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
Rao
Angela
A
Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata 98168, Messina, Italy.
Carbone
Anna
A
Chimirri
Alba
A
De Clercq
Erik
E
Monforte
Anna Maria
AM
Monforte
Pietro
P
Pannecouque
Christophe
C
Zappalà
Maria
M
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D015498:HIV-2 / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D013844:Thiazoles