title: Function of the proximal stomach after partial versus complete laparoscopic fundoplication.
abstract: OBJECTIVE
  After antireflux surgery, more than 30% of patients develop dyspeptic symptoms such as fullness and early satiety. We have previously shown that these symptoms are related to fundoplication-induced changes in proximal gastric motor and sensory function, especially impaired postprandial relaxation. We hypothesize that impaired fundus relaxation may be more pronounced after complete versus partial fundoplication.
  
  
  METHODS
  Fasting and postprandial proximal gastric motor and sensory function were measured with an electronic barostat in patients after laparoscopic partial (n = 14) and complete (n = 14) fundoplication, in gastroesophageal reflux disease (GERD) patients (n = 12), and in healthy control subjects (n = 15). Gastric emptying and vagus nerve function tests were performed in all patients.
  
  
  RESULTS
  Minimal distending pressure (MDP) and proximal gastric compliance were not significantly different among patients after antireflux surgery, GERD patients, and healthy controls. Maximal postprandial fundus relaxation was significantly (p < 0.01) reduced in patients after partial (267 +/- 32 ml) and complete (294 +/- 34 ml) fundoplication compared with GERD patients (448 +/- 30 ml) and healthy controls (409 +/- 25 ml). Sensations of fullness were not significantly different between patients with partial and complete fundoplication. There was a significant positive correlation between the postoperative duration and the degree of postprandial fundus relaxation (r = 0.67; p < 0.001).
  
  
  CONCLUSIONS
  Both after complete and after partial fundoplication, proximal gastric motor function is affected, with impaired postprandial relaxation and increased sensation of fullness. These alterations are not related to the type of fundoplication but correlate significantly with the duration of the postoperative period.
authors.affiliation: Department of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
authors.forename: M Y A
authors.initials: MY
authors.lastname: Lindeboom
authors.forename: M K
authors.initials: MK
authors.lastname: Vu
authors.forename: J
authors.initials: J
authors.lastname: Ringers
authors.forename: P J J
authors.initials: PJ
authors.lastname: van Rijn
authors.forename: P
authors.initials: P
authors.lastname: Neijenhuis
authors.forename: A A M
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D000328:Adult; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005746:Gastric Emptying / Q000502:physiology; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008365:Manometry; D008875:Middle Aged; D012677:Sensation / Q000502:physiology; D013270:Stomach / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology