[Expression of TGF beta 1 and TGF beta RI proteins in tissues of salivary adenoid cystic carcinoma].
OBJECTIVE
To determine the possible role of TGF beta 1 and TGF beta RI in facilitating neoplastic progression in human salivary adenoid cystic carcinoma (ACC).


METHODS
The expression of TGF beta 1 and TGF beta RI protein in human salivary adenoid cystic carcinoma was detected by the streptavidin-peroxidase (S-P) immunohistochemical method, and their contents were compared with those of normal salivary gland tissues and salivary pleomorphic adenoma (PA).


RESULTS
1. TGF beta 1 and TGF beta RI proteins were expressed in most ductal epithelial cells and myo-epithelial cells, but they were not expressed in the acinar epithelial cells of any normal glands examined; 2. TGF beta 1 and TGF beta RI proteins were expressed in the duct-like arranging tumor cells and other solid proliferating tumor cells of salivary pleomorphic adenoma, and no difference of their contents existed between PA and normal salivary gland tissues (P > 0.05); 3. The contents of TGF beta 1 in ACC were significantly higher than those in normal salivary glands (P < 0.01), while the contents of TGF beta RI in ACC were significantly lower than those in normal salivary glands (P < 0.01).


CONCLUSIONS
The abnormal expression of TGF beta 1 and TGF beta RI might play an important role in tumor genesis and the development of malignant salivary gland tumors such as ACC; the over-expression of TGF beta 1 and low-expression of TGF beta RI might involve the bad biological behavior of ACC.
Guo
Feng
F
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Jian
Xin-chun
XC
Cheng
Rui-xue
RX
D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism*; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000096:biosynthesis*; D012468:Salivary Gland Neoplasms / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D053773:Transforming Growth Factor beta1
D014408:Biomarkers, Tumor; D018125:Receptors, Transforming Growth Factor beta; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1