[Molecular virology of hepatitis C].
Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Here, we will briefly review current concepts of the molecular virology of hepatitis C. In vitro and in vivo models of HCV replication will be discussed in this context. Finally, novel antiviral strategies will be outlined that result from an improved understanding of the viral life cycle.
Moradpour
D
D
Abteilung Innere Medizin II, Medizinische Universitätsklinik Freiburg i. Br. Darius.Moradpour@uni-freiburg.de
Brass
V
V
Gosert
R
R
Wölk
B
B
Blum
H E
HE
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005544:Forecasting; D005814:Genes, Viral; D015316:Genetic Therapy; D016174:Hepacivirus / Q000201:enzymology / Q000235:genetics* / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy / Q000628:therapy* / Q000821:virology*; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D002679:Pan troglodytes; D020815:Polyproteins / Q000235:genetics / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics; D012093:Replicon / Q000235:genetics; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D014417:Tupaia; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D020815:Polyproteins; D011480:Protease Inhibitors; D012367:RNA, Viral; D014764:Viral Proteins