title: Oxidative burst of Kupffer cells: target for liver injury treatment.
abstract: Liver injury, and frequent consequent fibrosis, is the focus of a number of research groups ranging from molecular biologists to clinicians. It encompasses many aspects and approaches. Among biochemical events the role of Kupffer cells, oxidative stress and pro-inflammatory mediators are eminent. In this review we focus on recent findings into use of natural substances for the modulation of oxidative burst as well as production of inflammatory mediators by Kupffer cells.
authors.affiliation: Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Jirí
authors.initials: J
authors.lastname: Vrba
authors.forename: Martin
authors.initials: M
authors.lastname: Modrianský
mesh_terms: D016207:Cytokines / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007728:Kupffer Cells / Q000378:metabolism* / Q000502:physiology; D016897:Respiratory Burst
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators