Effect of obesity and/or sleep apnea on chemosensitivity: differences between men and women.
The purpose of this study was to identify if obesity or obstructive sleep apnea (OSA) influence hypercapnic response (HCR) and hypoxic response (HR) taking into account differences between gender. Data are expressed in % predicted based on reference values of our laboratory ('Respir. Physiol. 113 (1998) 157'). Obese women without OSA (n=117, body mass index (BMI) 43+/-8 kg/m(2)) demonstrated an increased ventilatory (VE) and occlusion pressure (P(0.1)) HCR and HR slope: VE HCR 113 (NS), VE HCR/vital capacity (VC) 126 (P<0.05), P(0.1) HCR 130 (P<0.05), VE HR 136 (P<0.05), VE HR/VC 154 (P<0.001) and P(0.1) HR 210 (P<0.001) % predicted. Obese women with OSA (n=34, BMI 42+/-9 kg/m(2)) presented similar increased values for HCR and even more increased values for HR than obese women without OSA matched for age, height and BMI: VE HR 155 (P=NS), VE HR/VC 205 (P<0.05) and P(0.1) HR 273 (P<0.05) % predicted. In obese men (without or with OSA) HCR and HR values were similar to our reference values.
Buyse
Bertien
B
Department of Pulmonology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. bertien.buyse@uz.kuleuven.ac.be
Markous
Nikolaos
N
Cauberghs
Michel
M
Van Klaveren
Rob
R
Muls
Erik
E
Demedts
Maurits
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002628:Chemoreceptor Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D012129:Respiratory Function Tests / Q000706:statistics & numerical data; D012727:Sex Characteristics; D012891:Sleep Apnea Syndromes / Q000378:metabolism* / Q000503:physiopathology; D018709:Statistics, Nonparametric