title: Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.
abstract: A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.
authors.affiliation: Department of Natural Product Chemistry, Shenyang Pharmaceutical University, China. shuyu@uakron.edu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.forename: Kwok-Min
authors.initials: KM
authors.lastname: Hui
authors.forename: Suixu
authors.initials: S
authors.lastname: Xu
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
authors.forename: J Tze Fei
authors.initials: JT
authors.lastname: Wong
authors.forename: Hong
authors.initials: H
authors.lastname: Xue
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004121:Dimethyl Sulfoxide; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D005445:Flunitrazepam / Q000493:pharmacokinetics; D018757:GABA Modulators / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism*; D031363:Scutellaria / Q000737:chemistry*
chemical_list: C471750:5,7,2'-trihydroxy-6,8-dimethoxyflavone; C471749:6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone; D005419:Flavonoids; D018757:GABA Modulators; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D004121:Dimethyl Sulfoxide