[Structural elucidation of a new tetrahydroxystilbene of Radix Polygoni Multiflori Preparata and study on its cardiovascular activity].
OBJECTIVE
To investigate the cardiovascular active constituents of Radix Polygoni multiflori Preparata.


METHODS
Compounds were isolated from the water soluble extract with column chromatography of Sephadex, ODS and HPLC. The compounds were identified on the basis of spectral analysis (IR, EI-MS, FAB-MS, 1HNMR, 13CNMR, 2D-NMR) and phytochemical properties. Its inhibitory effect on the proliferation of bovine vascular smooth muscle cells were bioassayed in vitro.


RESULTS
One compound was isolated and identified as: 2,3,5,4'-tetrahydroxystilbene-2-O-(6"-O-alpha-D- glucopyranosyl)-beta-D-glucopyranoside.


CONCLUSIONS
Compound I is a new compound with cardiovascular activity.
Chen
W S
WS
College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Liu
W Y
WY
Yang
G J
GJ
Zhang
W D
WD
Chu
Z Y
ZY
Chen
H S
HS
Qiao
C Z
CZ
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C477446:2,3,5,4'-tetrahydroxystilbene-2-O-(6''-O-glucopyranosyl)glucopyranoside; D004187:Disaccharides; D013267:Stilbenes