title: Prognostic value of ST-segment resolution-when and what to measure.
abstract: OBJECTIVE
  Analyses of ST-segment resolution during acute myocardial infarction has, during recent years, challenged coronary angiography as gold-standard for predicting myocardial reflow and future risk. We have previously reported that continuous ST-monitoring can be done accurately in the clinical setting. We now set out to compare the prognostic value of previously suggested cut-offs for ST-segment resolution, and determine the times to measure these.
  
  
  RESULTS
  We analysed 752 patients with ST-elevation infarction, from the second Assessment of Safety and Efficacy of a New Thrombolytic (ASSENT 2) and ASSENT-PLUS studies, either with vectorcardiography or continuous 12-lead ST-monitoring. All analyses were made blindly by two independent observers. Times to 20, 30, 50 and 70% ST-segment resolution were examined in relation to 30-day mortality.The optimal cut-off for ST-segment resolution analyses was found to be 50%, measured at 60 min. We could hereby identify a large low-risk group, 40% of the population, with only 1.4% 30-day mortality. Furthermore, 88% of deaths were correctly predicted within 1h of observation and treatment.
  
  
  CONCLUSIONS
  Continuous ST-monitoring of patients with acute myocardial infarction yields important prognostic information after 60 min of observation and should be used for very early-risk stratification in these patients.
authors.affiliation: Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Ostra, SE-41685 Göteborg, Sweden. pj@hjl.gu.se
authors.forename: Per
authors.initials: P
authors.lastname: Johanson
authors.forename: Tomas
authors.initials: T
authors.lastname: Jernberg
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gunnarsson
authors.forename: Bertil
authors.initials: B
authors.lastname: Lindahl
authors.forename: Lars
authors.initials: L
authors.lastname: Wallentin
authors.forename: Mikael
authors.initials: M
authors.lastname: Dellborg
mesh_terms: D000368:Aged; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D014672:Vectorcardiography / Q000379:methods