title: Modular approach to novel chiral aryl-ferrocenyl phosphines by Suzuki cross-coupling.
abstract: Two novel planar chiral and atropisomeric P,N and P,O aryl-ferrocenyl ligand systems have been developed. The strategy is short and involves a new synthetic approach to aryl-ferrocenyl compounds via a Suzuki cross-coupling procedure. The modular design can easily give access to variety of chiral mono- and bidentate ligands. Two simple derivatives of a novel chiral bidenate P,N ligand belonging to the MOPF family have been synthesized and tested in the enantioselective copper-catalyzed addition of diethyl zinc to an enone and a "difficult" diester. Moderate to excellent yields and enantioselectivities up to 58% were obtained using 1 mol % Cu(OTf)(2) and 1.5 mol % chiral ligand.
authors.affiliation: Department of Chemistry, Building 201 and 206, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Jakob F
authors.initials: JF
authors.lastname: Jensen
authors.forename: Inger
authors.initials: I
authors.lastname: Søtofte
authors.forename: Henning O
authors.initials: HO
authors.lastname: Sørensen
authors.forename: Mogens
authors.initials: M
authors.lastname: Johannsen