[Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide].
The effect and the mechanism of Lycium barbarum polysaccharide (LBP-X) on inhibiting the growth of human leukemia HL-60 cells were examined. LBP-X(20, 100, 500, 1000 mg/L) could inhibit the growth of HL-60 cells in dose-dependent manner and decrease the membrane fluidity of the cell. Agarose gel electrophoresis of DNA from the cells treated with LBP-X revealed a "DNA ladder" and positive TUNEL test. The results showed that the apoptosis of HL-60 cells induced by LBP-X maybe its important mechanism on anti-tumorgenesis.
Gan
L
L
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Wang
J
J
Zhang
S
S
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells / Q000166:cytology; D006801:Humans; D032305:Lycium / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides