title: Chronic cough induced by abacavir apart from a context of hypersensitivity.
abstract: We report the case of an HIV-infected woman, who presented with chronic and productive cough without sign of hypersensitivity (fever, cutaneous eruption, gastrointestinal disorders), while taking abacavir. All complementary exams being negative, the involvement of abacavir has been suspected. So the drug was stopped leading to a rapid disappearance of cough. It is the first report of chronic cough with abacavir apart of a context of hypersensitivity reaction.
authors.affiliation: Pharmacovigilance Center, St Charles Hospital, CHU Montpellier, 34295 Montpellier.
authors.forename: H
authors.initials: H
authors.lastname: Peyrière
authors.forename: J M
authors.initials: JM
authors.lastname: Mauboussin
authors.forename: A
authors.initials: A
authors.lastname: Arnaud
authors.forename: I
authors.initials: I
authors.lastname: Rouanet
authors.forename: D
authors.initials: D
authors.lastname: Vincent
mesh_terms: D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active; D048588:Benzoxazines; D002908:Chronic Disease; D003371:Cough / Q000139:chemically induced*; D003521:Cyclopropanes; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008875:Middle Aged; D019888:Nelfinavir / Q000627:therapeutic use; D010078:Oxazines / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012220:Rhinitis / Q000139:chemically induced; D013183:Sputum; D018119:Stavudine / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D000099227:Abacavir
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D015224:Dideoxynucleosides; D017320:HIV Protease Inhibitors; D019259:Lamivudine; D019888:Nelfinavir; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000099227:Abacavir; C098320:efavirenz