Choroidal vascular lesions identified by ICG angiography in a case of familial amyloidotic polyneuropathy.
BACKGROUND
To describe a patient with familial amyloidotic polyneuropathy (FAP) whose choroidal vascular lesions were demonstrated dynamically with the use of indocyanine green (ICG) angiography.


METHODS
A 59-year-old man complained of blurred vision due to vitreal amyloidosis in both eyes. Fundus examination after pars plana vitrectomy showed multiple retinal hemorrhages.


METHODS
ICG angiography performed after vitrectomy clearly delineated multiple sites of hyperfluorescence indicating tissue staining alongside the major choroidal veins in the lower fundus of his left eye. ICG hyperfluorescence was more evident in the late angiographic phase. Fundus examination and fluorescein angiography revealed no abnormal findings at the corresponding sites of ICG dye leakage.


CONCLUSIONS
Choroidal vascular lesions in eyes with FAP were demonstrated in vivo using ICG angiography for the first time. ICG angiography may be very beneficial to evaluate occult choroidal involvement in patients with FAP.
Kojima
Ariko
A
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Ohno-Matsui
Kyoko
K
Mitsuhashi
Tamaki
T
Ichinose
Shizuko
S
Nemoto
Tetsuo
T
Akashi
Takumi
T
Eishi
Yoshinobu
Y
Ikeda
Shu-ichi
S
Hirose
Akira
A
Mochizuki
Manabu
M
D028227:Amyloid Neuropathies, Familial / Q000175:diagnosis*; D002829:Choroid / Q000098:blood supply*; D004396:Coloring Agents; D005128:Eye Diseases / Q000175:diagnosis*; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D014680:Veins; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*
D004396:Coloring Agents; D007208:Indocyanine Green