title: Synthesis and structural study of substituted thioxothiazolidinones and thioxoimidazolidinones.
abstract: A new set of derivative thioxothiazolidinones and thioxoimidazolidinones 3,5-dissubstituted has been synthesized with satisfactory yield from the condensation Knoevenagel type between benzaldéhydes and 4-thioxothiazolidin-2-one, 2-thioxothiazolidin-4-one and 1-méthyl-2-thioxoimidazolidin-4-one compounds following by N-alkylation with aryl or acyl halides. The physico-chemical properties of the 5-benzylidene-3-[2-(4-chlorophenyl)-2-oxoethyl]-2 (or 4)-thioxothiazolidin-4 (or 2)-ones and 5-benzylidene-1-methyl-2-thioxoimidazolidin-4-ones synthesized have been described.
authors.affiliation: Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, João Pessoa, Brasil.
authors.forename: A M C
authors.initials: AM
authors.lastname: Andrade
authors.forename: W T
authors.initials: WT
authors.lastname: Lima
authors.forename: M P A
authors.initials: MP
authors.lastname: Rocha
authors.forename: M C A
authors.initials: MC
authors.lastname: Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: J M
authors.initials: JM
authors.lastname: Barbosa Filho
authors.forename: A J S
authors.initials: AJ
authors.lastname: Góes
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
mesh_terms: D000478:Alkylation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D007202:Indicators and Reagents; D013844:Thiazoles; D013871:Thiones