C2-symmetric bissulfoximines as ligands in copper-catalyzed enantioselective Diels-Alder reactions.
[reaction: see text] Bissulfoximines have been used as chiral ligands in copper-catalyzed enantioselective Diels-Alder reactions between acryloyl-2-oxazolidinones and cyclopentadiene. After optimizing the ligand structure, the metal source, the counterions, and the solvent, products with up to 93% ee have been obtained.
Bolm
Carsten
C
Institute of Organic Chemistry, RWTH Aachen Professor-Pirlet-Strasse 1, D-52056 Aachen, Germany. carsten.bolm@oc.rwth-aachen.de
Martin
Marc
M
Simic
Oliver
O
Verrucci
Marinella
M