title: Inverse relationship between density of cutaneous hair and pigmented lesion count in patients with malignant melanoma.
abstract: The aim of this study was to investigate whether there is an inverse relationship between the density of cutaneous hair and the number of pigmented lesions in patients with malignant melanoma, and to review the clinical and experimental findings with regard to this relationship. Cutaneous hair density and pigmented lesion counts were determined at nine sites by two physicians using specified criteria in 10 patients with a history of malignant melanoma and 22 control subjects. Study participants were Caucasian males of similar age, height and weight, and had similar occupational, ethnic, socioeconomic and sun exposure backgrounds. Statistical analysis was performed using combined data from all the sites and individual site data to determine whether an inverse relationship between cutaneous hair density and pigmented lesion counts exists. The results demonstrated statistically significant inverse relationships for the chest, upper back, upper arm and forearm in the melanoma patients, but not in the controls. For all the sites combined, both groups demonstrated statistically significant inverse relationships. The study findings are consistent with the hypothesis that some pigmented lesions may arise from the melanocytes of the hair follicle. This hypothesis may lead to new approaches to studying and treating melanoma.
authors.affiliation: Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Tobacman
authors.forename: D
authors.initials: D
authors.lastname: Whitaker
authors.forename: B
authors.initials: B
authors.lastname: Zimmerman
mesh_terms: D000328:Adult; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D006197:Hair / Q000378:metabolism* / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008548:Melanosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D012880:Skin Pigmentation; D013472:Sunlight / Q000009:adverse effects