title: [Infection-induced urinary stones].
abstract: Infection stones make up approximately 15% of urinary stone diseases and are thus an important group. These stones are composed of struvite and/or carbonate apatite. The basic precondition for the formation of infection stones is a urease-positive urinary tract infection. Urease is necessary to split urea into ammonia and CO(2). As a result, ammonia ions can form and at the same time alkaline urine develops, both being preconditions for the formation of struvite and carbonate apatite crystals. When these crystals are deposited infection stones form. Pathogenetically, various risk factors play a role: urinary obstruction, neurogenic bladder, dRTA, and MSK. If these infections are not treated and the stones are not removed, the kidney will be damaged. Modern methods are available for stone removal, e.g., ESWL and/or instrumental urinary stone removal. Here, especially less invasive methods are preferable. Any treatment must be adjusted to the patient individually. Patients should be examined frequently for recurrent urinary tract infections and stone recurrences, and new infections must be resolutely treated. Good therapy and prophylaxis are possible with present-day treatment modalities.
authors.affiliation: Klinik und Poliklinik für Urologie, Eberhard-Karls-Universität, Tuebingen. bichler@med.uni-tuebingen.de.
authors.forename: K-H
authors.initials: KH
authors.lastname: Bichler
authors.forename: E
authors.initials: E
authors.lastname: Eipper
authors.forename: K
authors.initials: K
authors.lastname: Naber
mesh_terms: D001031:Apatites / Q000652:urine; D001419:Bacteria / Q000201:enzymology / Q000302:isolation & purification; D015897:Comorbidity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017616:Magnesium Compounds / Q000652:urine; D010710:Phosphates / Q000652:urine; D012307:Risk Factors; D000069877:Struvite; D014510:Urease / Q000378:metabolism; D014545:Urinary Calculi / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D014567:Urography
chemical_list: D001031:Apatites; D017616:Magnesium Compounds; D010710:Phosphates; C030782:carboapatite; D000069877:Struvite; D014510:Urease