Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.
A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.
Wang
Hongyan
H
Department of Natural Product Chemistry, Shenyang Pharmaceutical University, China. shuyu@uakron.edu
Hui
Kwok-Min
KM
Xu
Suixu
S
Chen
Yingjie
Y
Wong
J Tze Fei
JT
Xue
Hong
H
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D004121:Dimethyl Sulfoxide; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D005445:Flunitrazepam / Q000493:pharmacokinetics; D018757:GABA Modulators / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism*; D031363:Scutellaria / Q000737:chemistry*
C471750:5,7,2'-trihydroxy-6,8-dimethoxyflavone; C471749:6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone; D005419:Flavonoids; D018757:GABA Modulators; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D004121:Dimethyl Sulfoxide