title: 2,5-Bis-(2-hydroxybenzoylamino)pentanoic acid, a salicylic acid-metabolite isolated from chicken: characterization and independent synthesis.
abstract: From excreta of chickens that had been treated with sodium salicylate, a new compound was detected and identified as a double conjugated ornithine metabolite. The structural assignment of this metabolite was further confirmed by an independent efficient 3-step synthesis from ornithine.
authors.affiliation: Ghent University, Faculty of Pharmaceutical Sciences, Laboratory for Medicinal Chemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Hillaert
authors.forename: Kris
authors.initials: K
authors.lastname: Baert
authors.forename: Jef
authors.initials: J
authors.lastname: Rozenski
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
authors.forename: Denis
authors.initials: D
authors.lastname: De Keukeleire
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.forename: Serge
authors.initials: S
authors.lastname: Van Calenbergh
mesh_terms: D000215:Acylation; D000818:Animals; D001711:Biotransformation; D002645:Chickens / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010421:Pentanoic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D020156:Salicylic Acid / Q000097:blood*
chemical_list: C476318:2,5-bis-(2-hydroxybenzoylamino)pentanoic acid; D007202:Indicators and Reagents; D010421:Pentanoic Acids; D020156:Salicylic Acid