title: Botanicals and dietary supplements in diabetic peripheral neuropathy.
abstract: BACKGROUND
  Many persons use botanicals and dietary supplements for chronic conditions that do not respond to traditional Western medications. Tricyclic antidepressants, a common treatment option for diabetic neuropathy, can have many side effects and are a poor choice in certain populations (eg, the elderly). As such, patients might turn to botanicals and dietary supplements, not realizing that these products are not well regulated.
  
  
  METHODS
  This article reviews botanicals and dietary supplements that have been involved in randomized controlled trials (RCTs) for diabetic neuropathy. We searched MEDLINE for English-language literature dating from 1966 to April 2001 using the following subject headings: (1) diabetes and botanical, herb, and supplement, (2) neuropathy and botanical, herb, and supplement, and (3) diabetic neuropathy and botanical, herb, and supplement.
  
  
  RESULTS
  Our search found agents that might improve symptoms of neuropathy (eg, evening primrose oil, alpha-lipoic acid, capsaicin) without affecting glucose control. Botanicals and dietary supplements involved in only one RCT or associated with little clinical benefit were reviewed in brief.
  
  
  CONCLUSIONS
  Evening primrose oil, alpha-lipoic acid, and capsaicin have received the greatest attention for their use in diabetic neuropathy, but further studies are needed to confirm their efficacy. Patients using these products need to be informed of potential drug interactions and side effects.
authors.affiliation: California College of Podiatric Medicine, San Francisco, Calif, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Halat
authors.forename: Cathi E
authors.initials: CE
authors.lastname: Dennehy
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D002211:Capsaicin / Q000494:pharmacology / Q000627:therapeutic use; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use; D019587:Dietary Supplements; D005228:Fatty Acids, Essential / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008041:Linoleic Acids; D031665:Oenothera biennis; D008517:Phytotherapy; D010938:Plant Oils; D008063:Thioctic Acid / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome; D017965:gamma-Linolenic Acid
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010938:Plant Oils; C028498:evening primrose oil; D008063:Thioctic Acid; D017965:gamma-Linolenic Acid; D002211:Capsaicin