title: Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
abstract: Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a variously substituted phenyl ring at N-3 have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata 98168, Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rao
authors.forename: Anna
authors.initials: A
authors.lastname: Carbone
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Monforte
authors.forename: Pietro
authors.initials: P
authors.lastname: Monforte
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Maria
authors.initials: M
authors.lastname: Zappalà
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D015498:HIV-2 / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D013844:Thiazoles