On the integration of subthreshold inputs from Perforant Path and Schaffer Collaterals in hippocampal CA1 pyramidal neurons.
Using a realistic model of a CA1 hippocampal pyramidal neuron, we make experimentally testable predictions on the roles of the non-specific cation current, I(h), and the A-type Potassium current, I(A), in modulating the temporal window for the integration of the two main excitatory afferent pathways of a CA1 neuron, the Schaffer Collaterals and the Perforant Path. The model shows that the experimentally observed increase in the dendritic density of I(h) and I(A) could have a major role in constraining the temporal integration window for these inputs, in such a way that a somatic action potential (AP) is elicited only when they are activated with a relative latency consistent with the anatomical arrangement of the hippocampal circuitry.
Migliore
Michele
M
Section of Neurobiology, Yale University School of Medicine, New Haven, CT, USA. migliore@spine.med.yale.edu
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D019580:Perforant Pathway / Q000502:physiology*; D009435:Synaptic Transmission; D013997:Time Factors