[Cerebral palsy: new pathogenetic concepts].
OBJECTIVE
To review the current knowledge pertaining to the new pathogenetic aspects of cerebral palsy (CP).


METHODS
CP is a group of static, heterogeneous clinical syndromes, characterized by abnormal postural mechanisms and motor activities. Its prevalence in industrialized countries is 2 2.5/1000 newborns. CP should be differentiated from certain genetic or metabolic conditions with which it can be mistaken. Some cases of CP have a genetic basis and they are inherited following a mendelian pattern or are determined by specific isolated genes. Recently, the elevation of certain coagulation factors (i.e., Leiden factor V mutation) and cytokines (i.e. interleukins, a tumor necrosis factor) and interferons have been related to CP pathogenesis. Hypocapnia with PaCO2< 35 mmHg represents a risk for periventricular leukomalacia (PVL) in premature infants. PVL pathogenesis is complex and includes a series of mechanisms that interact among them: fetal/maternal infection, immuneinflammatory reaction, prematurity, intraventricular hemorrhage/iron, ischemia/reperfusion, free radical production, maturational sensitivity of oligodendrocytes, and glutamate effect. Neuroradiological and neuropathological data have demonstrated a cortical anatomical substrate for the intellectual deficits associated with PVL in premature infants.


CONCLUSIONS
Current knowledge about CP pathogenesis opens the possibility of early diagnosis and development of new treatments, both therapeutic and preventive.
Legido
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Departamento de Pediatría Sección de Neurología, St. Christopher s Hospital for Children, College of Pennsylvania, Hahnemann University, Philadelphia, PA 19134-1095, USA. agustin.legido@drexel.edu
Katsetos
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CD
D001921:Brain / Q000378:metabolism / Q000473:pathology; D002547:Cerebral Palsy / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D016207:Cytokines / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology / Q000235:genetics / Q000503:physiopathology
D016207:Cytokines