title: [Promotion of Thrombopoiesis by rhIL-11 in Normal and Myelosuppressed Mice]
abstract: Hematological effects of rhIL-11 on normal and myelosuppressed male BALB/c mice were observed. Mice were subcutaneously injected with rhIL-11 for 7 consecutive days, at the dose of 200 or 400 micro g/kg per day, peripheral blood platelet counts were moderately elevated on 5 days after administration and returned to base level within 4 days after discontinuation of injection. In myelosuppressed mice, treatment with rhIL-11 significantly ameliorated the degree of thrombocytopenia, the recovery of thrombocytopenia was also significantly accelerated at the dose range of 100 - 400 micro g/kg per day, and blood platelet counts reached pre-irradiated level after 13 - 15 days of treatment. The magnitudes of platelet count elevation were similar among groups of 100, 200 and 400 micro g/kg per day, although recovery appeared earlier in group of 400 micro g/kg per day. Significant increases in CFU-Meg were observed both in normal and myelosuppressed mice. Our results suggest that rhIL-11 promotes the increase of peripheral blood platelets both in normal and myelosuppressed mice, and can be used as a potential therapeutic agent for thrombocytopenia induced by chemotherapy.
authors.affiliation: Beijing Shuanglu Biopharmaceutical Co Ltd. and Beijing Shuanglu Institute of Medicinal Biotechnology, Beijing 100041, China; Beijing Zhaoyan New Drug Research Center, Beijing 100850, China.
authors.forename: Conglin
authors.initials: C
authors.lastname: Zuo
authors.forename: Mingbo
authors.initials: M
authors.lastname: Xu
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Yi
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Feng
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Huang