Successful treatment of Candida albicans osteomyelitis of the spine with fluconazole and surgical debridement: case report.
A 65-year old diabetic male presented with progressive bone destruction of thoracic spine (T-11&12) with cord compression. Candida albicans was isolated from aspirated materials pre-and intra-operative. Two weeks of fluconazole was given prior to surgical debridement, and fixation of the lesion. C. albicans isolated pre-and 2-weeks after fluconazole treatment were DNA-typed using AP-PCR. MIC was 2-4 mg/l in all isolates tested. The pre-and post treatment isolates had two DNA patterns, indicating the existence of two different strains. Surgical treatment was necessary for patient recovery.
El-Zaatari
M M
MM
Hammoud Hospital, Saida, Lebanon. me09@aub.edu.lb
Hulten
K
K
Fares
Y
Y
Baassiri
A
A
Balkis
M
M
Almashhrawi
A
A
El-Zaatari
F A K
FA
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000235:genetics*; D002177:Candidiasis / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D016172:DNA Fingerprinting; D004271:DNA, Fungal; D003646:Debridement; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D013117:Spinal Cord Compression / Q000150:complications; D013166:Spondylitis / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D013904:Thoracic Vertebrae
D000935:Antifungal Agents; D004271:DNA, Fungal; D015725:Fluconazole