A mono-diazenide complex from perrhenate: toward a new core for rhenium radiopharmaceuticals.
A new method for the synthesis of low to intermediate oxidation state rhenium complexes containing a bifunctional ligand has been developed. Reaction of [ReO(4)](-) with substituted phenylhydrazines and triphenylphosphine in acetonitrile in the presence of HCl allows the isolation of [ReCl(2)(NNC(6)H(4)-4-R)(NCCH(3))(PPh(3))(2)] (where R = OCH(3), Cl, or CO(2)CH(3)). The substituted hydrazine acts as both a reductant and source of a monodentate diazenide ligand. The compounds have all been characterized in the solid state by X-ray crystallography and in the solution state by NMR, electrospray mass spectrometry, and HPLC. Cyclic voltammetry measurements show that the mono-diazenide complexes undergo a reversible oxidation.
Cowley
Andrew R
AR
Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, U.K.
Dilworth
Jonathan R
JR
Donnelly
Paul S
PS
D002625:Chemistry, Organic / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D006834:Hydrazines; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C015428:perrhenate; C029424:hydrazine; D012211:Rhenium