[Serological study on inhibitory function of shenkang injection on glomerular mesangial cell].
OBJECTIVE
To explore the intensity of inhibitory function of Shenkang injection (SKI), a Chinese herbal recipe, and benazepril on the proliferation of human glomerular mesangial cell (MC).


METHODS
The effect of SKI and benazepril on the proliferation of human MC was observed by using the cultured MC in vitro and serum pharmacological assay.


RESULTS
Both SKI and benazepril could inhibit the proliferation of human MC, but in equal dosage consistency, SKI showed a better inhibitory effect than that of benazepril.


CONCLUSIONS
MC is the important target cell for the action of SKI, the inhibiting on proliferation might be one of the essential mechanisms of SKI in retarding glomerulosclerosis.
Guo
L Z
LZ
Nanjing University of Traditional Chinese Medicine, Nanjing 210029.
Mao
W
W
Wang
H M
HM
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005920:Glomerular Mesangium / Q000166:cytology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D006801:Humans; D011897:Random Allocation; D051381:Rats
D001552:Benzazepines; D004365:Drugs, Chinese Herbal; C044946:benazepril