[Effect of low-dosage aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in rabbits' blood].
OBJECTIVE
To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits' blood.


METHODS
Forty healthy New Zealand rabbits were divided into four groups. Blood samples were drawn from the rabbits' heart before and after a consecutive four-week. NE was measured by high performance liquid chromatography, and PGI2 and TXA2 were measured by radioimmunoassay.


RESULTS
ACE inhibitors increased PGI2 levels (P < 0.05, P < 0.01); low-dosage aspirin suppressed TXA2 productions (P < 0.05, P < 0.01) after the four-week administration. Aspirin combined with ACE inhibitors led to a significant increase in PGI2/TXA2(P < 0.01), together with a significant decrease in NE levels in the rabbits' blood (P < 0.001).


CONCLUSIONS
Neither low-dosage aspirin nor ACE inhibitors influence NE levels alone. The ratio of PGI2 to TXA2 increased, and NE levels decreased significantly during the administration of aspirin combined with ACE inhibitors. The results suggest that there is a synergis-action between low-dosage aspirin and ACE inhibitors due to increased PGI2/TXA2 and decreased NE levels.
Zhuang
Han-ping
HP
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Li
Jing
J
Fang
Yun-xiang
YX
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D020913:Perindopril / Q000494:pharmacology*; D011817:Rabbits; D013928:Thromboxane A2 / Q000097:blood*
D000806:Angiotensin-Converting Enzyme Inhibitors; D013928:Thromboxane A2; D011464:Epoprostenol; D001241:Aspirin; D009638:Norepinephrine; D020913:Perindopril