[Effects of Pedicularis decora extract on anti-oxidation injury in mice].
OBJECTIVE
To study the protection effects of Pedicalaris decorm extract on oxidation lesion in mice and the effective components of Pedicalaris decorm.


METHODS
The total extract, BuOH soluble components and water soluble components of Pedicalaris decorm were administered (ig) 15 g.kg-1.d-1 to mice, and the oxidation injury model in mice was induced by i.p. alloxan 180 mg.kg-1. SOD, GSH-Px and LPO in red blood cell and liver, ALT, AST, AKP and r-globulin in serum, LPO and MAO.B in brain, liver index and spleen index were measured.


RESULTS
All the three Pedicalaris decorm extracts can obviously lower abnormal contents of SOD, GSH-Px, LPO, ALT, AST, AKP, MAO.B and r-globulin induced by alloxa, and obviously improve abnormal decrease of liver index and spleen index.


CONCLUSIONS
Pedicalaris decorm extract can inhibit oxidation lesion in mice. The effects of total extract and BuOH soluble components were better than water soluble components.
Yang
Jianxiong
J
College of Life Science, Shaanxi Normal University, Xi'an 710062.
Gao
Meili
M
Li
Farong
F
D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D032262:Pedicularis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D000496:Alloxan