A case of pseudo-aprosencephaly.
We present a case of rare, severe brain malformations. In a microcephalic premature newborn only a small structure found in the base of the cranium corresponded to the prosencephalic part of the brain. The basal ganglia were lacking and the cortico-subcortical area changed into empty vesicles with only small fragments of cortical stripe. This picture authorises us to speak on the probably complex pathomechanism of anomalies: genetically caused malformations including underdevelopment of telencephalic nuclei and additional occurrence of extrinsic lesions leading to pseudo-aprosencephaly formation.
Dambska
Maria
M
Department of Developmental Neuropathology, Polish Academy of Sciences, Warszawa, Poland. folia@cmdik.pan.pl
Taraszewska
Anna
A
Czwalińska
Tamara
T
D000757:Anencephaly / Q000209:etiology / Q000473:pathology*; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature