title: Clinical exacerbation of multiple sclerosis following radiotherapy.
abstract: BACKGROUND
  Radiation of the central nervous system in patients with demyelinating disease may have deleterious effects.
  
  
  OBJECTIVE
  To describe a 30-year-old woman with multiple sclerosis who developed an attack of demyelination 2 months following radiotherapy for a parotid malignancy.
  
  
  RESULTS
  Magnetic resonance imaging demonstrated new hyperintense lesions that corresponded to both the localization of the patient's symptoms and to the area defined by the 50% isodose radiation field.
  
  
  CONCLUSIONS
  Radiation treatment likely triggered an exacerbation of multiple sclerosis.
authors.affiliation: Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Colleen B
authors.initials: CB
authors.lastname: Murphy
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Hashimoto
authors.forename: Douglas
authors.initials: D
authors.lastname: Graeb
authors.forename: Brian A
authors.initials: BA
authors.lastname: Thiessen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*; D010307:Parotid Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*