title: Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis.
abstract: Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC 50 : 1.33 +/- 0.05 microM) and schisandrol A (IC 50 : 1.34 +/- 0.05 microM) showed higher activity than gomisin E (IC 50 : 4.73 +/- 0.09 microM), schisandrin A (IC 50 : 7.23 +/- 0.21 microM), schisandrin C (IC 50 : 7.54 +/- 0.22 microM), benzoylisogomisin O (IC 50 : 11.06 +/- 1.02 microM) and schisandrol B (IC 50 : 16.37 +/- 1.00 microM).
authors.forename: Im Seon
authors.initials: IS
authors.lastname: Lee
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Lee
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Doe Sun
authors.initials: DS
authors.lastname: Na
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D019169:Jurkat Cells; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D032141:Schisandra / Q000737:chemistry*; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
chemical_list: D004268:DNA-Binding Proteins; D017705:Lignans; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors