title: Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC.
abstract: Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Richart
authors.forename: Scott A
authors.initials: SA
authors.lastname: Simpson
authors.forename: Claude
authors.initials: C
authors.lastname: Krummenacher
authors.forename: J Charles
authors.initials: JC
authors.lastname: Whitbeck
authors.forename: Lewis I
authors.initials: LI
authors.lastname: Pizer
authors.forename: Gary H
authors.initials: GH
authors.lastname: Cohen
authors.forename: Roselyn J
authors.initials: RJ
authors.lastname: Eisenberg
authors.forename: Christine L
authors.initials: CL
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D000075983:Nectins; D009475:Neurons, Afferent / Q000821:virology*; D051381:Rats; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000378:metabolism; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; C000619010:NECTIN1 protein, human; C000619015:Nectin1 protein, mouse; D000075983:Nectins; D018124:Receptors, Tumor Necrosis Factor; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus; C506028:TNFRSF14 protein, human; C506029:Tnfrsf14 protein, mouse