title: Evaluation of antipyretic activity of leaf extracts of Mallotus peltatus (Geist) Muell. arg. var acuminatus: a folk medicine.
abstract: A study was carried out to evaluate the anti-pyretic potential of the methanol extract of Mallotus peltatus (Geist) Muell. Arg. var acuminatus leaf, a folk medicine of Onge tribes of Bay Islands, on normal body temperature and yeast-induced pyrexia in Wister albino rats. The leaf extract at oral doses of 100, 200 and 300 mg kg(-1), p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner and the anti-pyretic effect was comparable to that of standard anti-pyretic agent paracetamol (150 mg kg(-1), p.o.). The effect also extended up to 5 hours after the drug administration.
authors.affiliation: ICMR Virus Unit Calcutta, Infectious Diseases & Beliaghata General Hospital, Kolkata, India. debprasadc@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Chattopadhyay
authors.forename: G
authors.initials: G
authors.lastname: Arunachalam
authors.forename: A B
authors.initials: AB
authors.lastname: Mandal
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000517:prevention & control*; D008297:Male; D036461:Mallotus Plant; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D013997:Time Factors; D015003:Yeasts
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen