[Curative effects of basic fibroblast growth factor on anus wound healing].
OBJECTIVE
To observe the curative effects of basic fibroblast growth factor (bFGF) on anus wound healing.


METHODS
From April 1996 to December 2000, out of 109 patients with anus trauma, hemorrhoidectomy or fistula resection, 68 were treated with bFGF as the experimental group, while 41 were treated routinely as the control group. The healing of the wound, the general and local reaction were observed.


RESULTS
The healing time of the experimental group was(17.00 +/- 1.54) days while that of the control group was(20.00 +/- 1.16) days (P < 0.01). Three weeks after operation, the healing rates of the experimental and control groups were 97.1% and 87.8%, respectively (P < 0.01). No general or local detrimental reactions were found in two groups.


CONCLUSIONS
Local application of bFGF can accelerate the healing of anus wound, and the patients have little pain.
Ge
Bu-jun
BJ
Department of General Surgery, Affiliated Tongji Hospital, Tongji University, Shanghai, P. R. China 200065.
Guo
Song-ming
SM
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D006484:Hemorrhoids / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000188:drug therapy / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D016222:Fibroblast Growth Factor 2