[Immunoregulation of IL-2 in Trichinella-infected mice].
OBJECTIVE
To study the immunoregulation of IL-2 in Trichinella-infected mice.


METHODS
Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated i.p. with IL-2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI).


RESULTS
In HL, higher dosage of IL-2 injection induced lower RCI and showed apparent anti-Trichinella effect. In AM, both low and high dose of IL-2 had no measurable effect on RCI, however, high dose of IL-2 reduced the infectivity of newborn larvae.


CONCLUSIONS
IL-2 exhibits apparent suppressive effect on the infectivity of T. spiralis of HL strain.
Niu
C
C
Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054.
Jiang
H
H
Huang
S
S
Zhu
X
X
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007074:Immunoglobulin G / Q000097:blood; D007376:Interleukin-2 / Q000494:pharmacology*; D007814:Larva / Q000276:immunology; D008297:Male; D051379:Mice; D017160:Trichinella spiralis / Q000187:drug effects / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007376:Interleukin-2