[Association of platelet endothelial cell adhesion molecule-1 gene polymorphism with coronary heart disease].
OBJECTIVE
To investigate the association of Leu125Val and Ser563Asn polymorphism of the gene encoding platelet endothelial cell adhesion molecule-1(PECAM-1) with coronary heart disease.


METHODS
This study included 156 patients with the diagnoses of coronary heart disease (CHD) and coronary lesions derived from electrocardiography, myocardial enzyme analysis and coronary angiography as the CHD group, and another 75 in-patients admitted within the same period who showed no signs of CHD in the above examinations constituted the control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to examine the missense polymorphism of PECAM-1gene in the position of Leu125Val and Ser563Asn.


RESULTS
There were significant differences between CHD and control group in terms of the allele frequencies and genotype distributions of PECAM-1 gene, and the differences were especially conspicuous in the allele frequencies of 125Val and 563Asn (P<0.05) and genotype distributions of 125Val/Val and 563Asn/Asn.


CONCLUSIONS
PECAM-1 gene polymorphism 1 may be a genetic risk factor for coronary heart disease.
Song
Fu-chun
FC
Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. chenaha@21cn.com
Chen
Ai-hua
AH
Tang
Xiao-ming
XM
Zhang
Wen-xiu
WX
Qian
Xue-xian
XX
Li
Jiang-qi
JQ
Lu
Qing
Q
D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics*; D011110:Polymorphism, Genetic
D019408:Platelet Endothelial Cell Adhesion Molecule-1