title: Evaluation of antiherpesvirus-1 and genotoxic activities of Helichrysum italicum extract.
abstract: The antiherpes virus-1 and genotoxic activities of diethyl ether extract from flowering tops of Helichrysum italicum (Compositae) were investigated. The extract showed significant antiviral activity at concentrations ranging from 400 to 100 microg/ml. This activity was not due to cytotoxic effect of the extract since Vero cells exhibited altered morphology or growth characteristics indicative of cytotoxic effects at higher concentration (800 microg/ml). Moreover H. italicum extract showed no DNA-damaging activity at concentrations up to 2000 microg/disk.
authors.affiliation: Dipartimento Farmaco-Biologico, Sezione Microbiologia, Facoltà di Farmacia, Università di Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nostro
authors.forename: M A
authors.initials: MA
authors.lastname: Cannatelli
authors.forename: A
authors.initials: A
authors.lastname: Marino
authors.forename: I
authors.initials: I
authors.lastname: Picerno
authors.forename: F C
authors.initials: FC
authors.lastname: Pizzimenti
authors.forename: M E
authors.initials: ME
authors.lastname: Scoglio
authors.forename: P
authors.initials: P
authors.lastname: Spataro
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D004249:DNA Damage; D004279:DNA, Viral / Q000378:metabolism; D035263:Flowering Tops / Q000737:chemistry; D036562:Helichrysum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D010936:Plant Extracts