Menstrual and reproductive factors and risk of lung cancer among Chinese women, Eastern Gansu Province, 1994-1998.
There are suggestions that women have higher relative risks of lung cancer than men given similar levels of tobacco exposure, implying that sex-related hormones may influence lung cancer risk. We evaluated the association between lung cancer risk and menstrual and reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu Province, China, 1994-1998. The analysis included 109 incident lung cancer cases and 435 controls selected from the census list and frequency matched to cases on age and prefecture. Odds ratios were lower for later ages at menarche (trend, P = 0.015) and later ages at menopause (trend, P = 0.074). Despite limitations, these findings suggest a possible role of hormones in the etiology of lung cancer in females.
Brenner
Alina V
AV
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, EPS, Bethesda, MD 20892, USA.
Wang
Zuoyuan
Z
Kleinerman
Ruth A
RA
Lei
Shujie
S
Metayer
Catherine
C
Wang
Wenlan
W
Lubin
Jay H
JH
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003268:Contraception Behavior; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008572:Menarche; D008593:Menopause; D008875:Middle Aged; D010298:Parity; D012307:Risk Factors; D011795:Surveys and Questionnaires