[The expression of human leukocyte antigen from peripheral blood of patients with herpetic keratitis].
OBJECTIVE
To understand the correlation between the expression of human leukocyte antigen from peripheral blood and herpetic keratitis so as to find the pathogenesis of HSK.


METHODS
The expression of HLA-ABC, HLA-DR, HLA-DP, HLA-DQ from peripheral blood of 32 cases with herpes simplex keratitis (the stromatic and ulcer herpetic keratitis are 16 cases respectively), comparing with the normal people, were investigated by flow cytometry.


RESULTS
The expression rate of HLA-ABC from peripheral blood of patients with herpetic keratitis (both the stromatic and ulcer groups) was lower, and the expression of HLA-DR and HLA-DP was higher than normal people. No difference was found between the stromatic and the ulcer herpetic keratitis in the expression of HLA-ABC, HLA-DR, HLA-DP, HLA-DQ.


CONCLUSIONS
The immune model in patients with herpetic keratitis is different from normal people. The individual with this kind of immune model can not destroy the infected virus effectively, also show autoimmunization to cornea.
Liu
Z
Z
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Chen
J
J
Li
S
S
Zeng
Y
Y
Sun
H
H
D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D015234:HLA-A Antigens / Q000097:blood; D006683:HLA-DQ Antigens / Q000097:blood; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D016849:Keratitis, Herpetic / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D015234:HLA-A Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens