Renal aquaporin water channels: from molecules to human disease.
Following the discovery of the aquaporin-1 water channel in 1991, molecular techniques have been developed to examine the roles of renal aquaporins-1, -2, -3, and -4 in disorders of water balance. This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states.
Schrier
Robert W
RW
Department of Medicine, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box B178, Denver, CO 80262, USA. Robert.Schrier@uchsc.edu
Cadnapaphornchai
Melissa A
MA
D051398:Aquaporin 1; D051399:Aquaporin 2; D051400:Aquaporin 3; D051401:Aquaporin 4; D051403:Aquaporin 6; D020346:Aquaporins / Q000502:physiology*; D001789:Blood Group Antigens; D003919:Diabetes Insipidus / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D014867:Water / Q000378:metabolism; D014883:Water-Electrolyte Imbalance / Q000473:pathology
C496020:AQP1 protein, human; C496023:AQP2 protein, human; C496027:AQP3 protein, human; C496030:AQP4 protein, human; D051399:Aquaporin 2; D051401:Aquaporin 4; D051403:Aquaporin 6; D020346:Aquaporins; D001789:Blood Group Antigens; D014867:Water; D051398:Aquaporin 1; D051400:Aquaporin 3