[The cardiovascular system of patients with lymphogranulomatosis in long-time remission].
OBJECTIVE
To study the cardiovascular system in patients with lymphogranulomatosis (LGM) at prolonged remission.


METHODS
78 patients received radiation and chemotherapy for lymphogranulomatosis in 1973 to 1995. All the patients underwent electro- and echocardiography (EchoCG), 40 patients had radioisotopic ventriculography (RVG).


RESULTS
EchoCG revealed nonspecific changes in the ST segment in 19 (24.3%) patients. Systolic function was decreased vto 46% only in 1 patient. RVG showed a significant reduction in ejection fraction in the experimental group as compared to the control one (55.5 +/- 9.5 and 68.4 +/- 8.0, respectively; p < 0.05).


CONCLUSIONS
Cardiac disorders revealed in patients with LGM at prolonged remission are mainly insignificant. The risk for cardiac events is not a guide for reducing radiation doses and the intensity of chemotherapy.
Nasibov
O M
OM
Pivnik
A V
AV
Pasha
S P
SP
Sotnikov
V M
VM
Shevelev
A A
AA
Dmitrieva
M G
MG
Molchanova
N P
NP
Stoliarova
T V
TV
D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002319:Cardiovascular System / Q000503:physiopathology*; D003627:Data Interpretation, Statistical; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis; D006689:Hodgkin Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015635:Radionuclide Ventriculography; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013318:Stroke Volume; D013997:Time Factors