title: Carcinoid tumor in the female urethral orifice: rare case report and a review of the literature.
abstract: We experienced an extremely rare tumor in the female urethral orifice in a 57-year-old Japanese woman. To our knowledge, only two cases of primary urethral carcinoid tumor have been reported. The previous reports of urethral carcinoid tumor were recognized in the male middle urethra and penile urethra. The present case was resected, and diagnosed as a carcinoid tumor by histological, immunohistochemical and ultrastructural findings. The tumor cells were stained by chromogranin A, synaptophsin and neuron-specific enolase, and neurosecretory granules were confirmed with electron microscopy. The patient did not complain of any symptoms until 5 years after the resection of the tumor. Therefore, the case we describe here is the first known report of carcinoid tumor in the Japanese female urethra.
authors.affiliation: Department of Pathology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Katayama
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kuno
authors.forename: Keiko
authors.initials: K
authors.lastname: Sakata
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Morioka
authors.forename: Morihiko
authors.initials: M
authors.lastname: Inamine
authors.forename: Chiken
authors.initials: C
authors.lastname: Shibuya
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002276:Carcinoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D022142:Secretory Vesicles / Q000648:ultrastructure; D016708:Synaptophysin / Q000032:analysis; D016896:Treatment Outcome; D014523:Urethral Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin