title: [Telomerase Activity Expressed in Acute Leukemia Cell]
abstract: To explore the possible linkage between telomerase and acute leukemia, we detected telomerase activity expressed in 3 leukemia cell lines, 22 acute leukemia bone marrow and 6 normal bone marrow with PCR ELISA assay. Results showed that telomerase activities of three leukemia cell lines were positive with the average (1.57 +/- 0.056) U, normal bone marrow samples average was (0.085 +/- 0.081) U, telomerase value from 22 acute leukemia patients was (0.512 +/- 0.294) U. Telomerase activity is higher expressed in acute leukemia than normal samples and decreased significantly after chemotherapy (P < 0.01). The results suggested that telomerase activity was related to some malignant diseases and might be used as a marker for tumor diagnosis and therapy.
authors.affiliation: Department of Hematology and Digestion, The General Military Regional Hospital of Lanzhou, Lanzhou 730050, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xi
authors.forename: Fang-Xin
authors.initials: FX
authors.lastname: Zhang
authors.forename: Ying-Xian
authors.initials: YX
authors.lastname: Ou
authors.forename: Hai
authors.initials: H
authors.lastname: Bai
authors.forename: Ya-Ming
authors.initials: YM
authors.lastname: Wei
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Xie