[Effect of "yang wei kang liu" granula on expression of P53 and PCNA in mice bearing sarcoma 180].
OBJECTIVE
To study possible mechanism of "Yang Wei Kang Liu" (YWKL) granula in treating tumor.


METHODS
Mice bearing sarcoma180 and immunohisto-chemical method were adopted.


RESULTS
Both YWKL granula and its cooperated chemothrapy could restrain the expression of P53 and PCNA. Compared with the chemotherapy group and the cooperated chemotherapy, YWKL granula group was significantly different.


CONCLUSIONS
YWKL granula could restrain the expression of P53 and PCNA, and increase the effect together with chemotherapy.
Cai
Y
Y
Jiangzhong Pharmaceutical Group Technology Center, Nanchang 330077.
Sun
G
G
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012510:Sarcoma 180 / Q000276:immunology / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; C531973:yang wei kang liu