[Antitumor effect of the extract of birch bark and its influence to the immune function].
OBJECTIVE
To study the antitumor effect of extract of birch bark (EBB) and its influence to the immune function of the tumor-bearing mice.


METHODS
EBB was administered orally and the tumor inhibiting effects were observed in tumor-bearing mice. Experiment of the immune function are to examine thymocytes (spleen) index, reaction of spleen to ConA and activity of NK cell.


RESULTS
EBB showed antitumor effect in vivo to B16, S180 and Lewis lung cancer in mice. EBB can significantly prolong survival period of bearing tumor mice. EBB can enhance thymocytes and spleen index in C57 BL/6 mice. EBB can enhance splenic lymphocytes translate and activit of NK cell (P < 0.05).


CONCLUSIONS
EBB have antitumor effect and enhance immune function in bearing tumor mice.
Han
S
S
Northchina Coal Medical College, Tangshan 063000.
Li
Z
Z
Li
Y
Y
Zhong
R
R
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D029662:Betula / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal