[Synthesis and insecticidal activity of the novel hydroxylbenzenedisulfonanilides compounds].
OBJECTIVE
To synthesize novel derivatives of hydroxylbenzenedisulfonanilide with high insecticidal activity against the Fasciola hepatica.


METHODS
o-(m-, p-) Chlorphenol were used to synthesize the title compounds by sulphonation and nucleiphilic-substitution reaction. The uncoupling activity (insecticidal activity) of these compounds were tested by determining the influence on mitochondrial respiration control ratio (RCR) and the variation of inorganic phosphate in oxidative phosphorylation (delta Pi).


RESULTS
Compounds 1-14 are new compounds. The structures of the compounds were determined by IR, HNMR and elemental analysis. Most new compounds have relatively high uncoupling activities, especially compounds 3, 5, 6 and 9.


CONCLUSIONS
Compounds 3, 5, 6 and 9 will become novel fasciolicides and are worth further studying.
Shi
Yu
Y
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China. shiyu1970@hotmail.com
Jiang
Ya-xin
YX
Niu
Xue-ping
XP
Zhao
Jun
J
Wang
Xiao-jing
XJ
Xin
Min
M
D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005210:Fasciola hepatica / Q000187:drug effects; D008930:Mitochondria, Liver / Q000502:physiology; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000813:Anilides; D000871:Anthelmintics; D013449:Sulfonamides