[Thermal decomposition kinetics of ribavirin and its stability].
OBJECTIVE
To study Thermal stabilities and thermal decomposition process of ribavirin and establish thermal decomposition kinetics equation.


METHODS
Thermal weight loss curve was obtained by thermogravimetry balance. Thermal decomposition function mode was also determined by Achar differential method and Coats-Redfern integral method.


RESULTS
Thermal decomposition kinetics parameters and kinetics compensation parameters were calculated from thermogravimetry-differential thermogravimetry data. Activation energy deduced by extrapolation under heating rate of 0 degree C.min-1 was 188.04 kJ.mol-1. Thermal decomposition kinetics function expression was d alpha/dt = Ae [formula: see text] (1 - alpha)2 and the mathematic expression of the kinetic compensation effect is found to be InA = 0.2264 Ea - 5.4458.


CONCLUSIONS
Ribavirin has high thermal stability because of its high thermal decomposition activation energy. The thermal decomposition activation of capsule is little lower than that of material, which indicates no evident difference in thermal stability for capsules and material.
Zhang
J
J
Department of Chemistry, South-Central College for Nationalities, Wuhan 430074, China. zj-88@263.net
Chen
D H
DH
Yuan
Y H
YH
Gong
Y W
YW
D000998:Antiviral Agents / Q000737:chemistry*; D002214:Capsules; D004355:Drug Stability; D006358:Hot Temperature; D007700:Kinetics; D012254:Ribavirin / Q000737:chemistry*
D000998:Antiviral Agents; D002214:Capsules; D012254:Ribavirin