Ovarian hyperstimulation-like syndrome after administration of triptorelin to a woman with endometriosis.
Ovarian hyperstimulation after a single dose of gonadotropin-releasing hormone (GnRH) analog is a rare phenomenon. A case of ovarian hyperstimulation-like syndrome after sole administration of triptorelin (Decapeptyl 3.75 mg) is reported in a woman who had undergone surgery for an endometriotic cyst. After administration of the drug, abdominal pressure increased with nausea and diffuse pelvic pain. Ultrasound examination showed bilateral enlargement of the ovaries (right 74 x 62 mm, left 62 x 53 mm), more than 10 follicles ranging in diameter from 15-25 mm, proliferative endometrium 7 mm thick and fluid in the Douglas pouch up to 25 x 23 mm thick. Estradiol plasma level was in the normal range. The syndrome spontaneously resolved in the course of treatment and a spontaneous pregnancy occurred when the triptorelin effect disappeared.
Inaudi
P
P
Department of Pediatrics, Obstetrics and Reproductive Medicine, Chair of Obstetrics and Gynecology, University of Siena, Viale Bracci, 53100 Siena, Italy.
Mazzini
M
M
D'Aniello
G
G
Trusso
P
P
Joghtapour
A
A
Petraglia
F
F
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D010535:Laparoscopy; D010048:Ovarian Cysts / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced*; D011247:Pregnancy; D014057:Tomography, X-Ray Computed; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000009:adverse effects*; D014463:Ultrasonography
D018394:CA-125 Antigen; D017329:Triptorelin Pamoate