[Detection of telomerase activity in gastric cancer and adjacent tissues].
OBJECTIVE
To study the telomerase activity in chinese gastric cancer and their adjacent tissues and to explore the possibility of telomerase as a tumor biological marker.


METHODS
Telomerase activity was analyzed in 42 primary gastric cancers and their adjacent tissues and 1 benign gastric lesion by a PCR-based telomerase repeat amplification protocol assay.


RESULTS
The result showed 88.1% (37/42) gastric cancerous specimens displayed telomerase activity. However, only 2 of 42 tissue samples adjacent to the gastric cancer showed telomerase activity. However our results indicated that 1 benign gastric lesion sample expressed telomerase activity.


CONCLUSIONS
The results indicated that the detection of telomerase activity might be a useful method in the diagnosis of gastric cancer.
Gao
F
F
Department of Abdominal Surgery and Centre of Tumor Biology, Cancer Hospital, CAMS and PUMC, Beijing 100021.
Zhang
W
W
Jing
S
S
Liu
Y
Y
Zhang
B
B
D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis / Q000201:enzymology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D019098:Telomerase / Q000378:metabolism*
D019098:Telomerase