[Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats].
OBJECTIVE
To observe the effect of Astragalus and Angelica on acute renal injury.


METHODS
Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed.


RESULTS
Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney.


CONCLUSIONS
Astragalus and Angelica have certain effect in protecting kidney from acute renal injury.
Sheng
M X
MX
Institute of Nephrology, First Affiliated Hospital of Beijing Medical University, Beijing 100034.
Li
J Z
JZ
Wang
H Y
HY
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply*; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal