[Correlation between expression of p53 and prognosis of laryngeal squamous carcinoma].
OBJECTIVE
p53 expression was a marker to predict the poor prognosis of laryngeal cancer. Detection of p53 in the pathological negative margin can be used to find more patients with poor prognosis. The aim of this study was to reveal the correlation between p53 expression and prognosis in primary cancer and surgical margin of laryngeal squamous cell carcinoma (SCC).


METHODS
The clinical data of 67 laryngeal SCC with pathological negative margin were analyzed retrospectively. The expression of p53 protein in the margin and primary cancer was detected by immunohistochemistry. The survival rates and the recurrent rates were compared between p53 positive and negative group both in surgical margin and primary cancer.


RESULTS
(1) The positive rates of p53 in surgical margin and primary cancer were 19.4% (13/67) and 50.7% (34/67), respectively. (2) The recurrent rate of positive margin group was higher than that of negative margin group (69.2% vs. 33.3%, P = 0.018). The survival rate of positive margin group was lower than that of negative margin group (24.62% vs. 75.69%, P = 0.0012). The recurrent rate of p53 positive primary cancer was higher than that of p53 negative primary cancer (64.7% vs. 15.2%, P = 0.0000). The survival rate of p53 positive primary cancer was lower than that of p53 negative primary cancer (42.86% vs. 90.86%, P = 0.0000).


CONCLUSIONS
The prognosis of those with p53 protein positive in the pathological margin or the primary cancer were worse than that of the negative group.
Xia
Liang-Ping
LP
Department of Head and Neck Surgery, Sun Yat-sen University, Guangzhou, Guangdong, 510060, R.P. China. tjkzl@gzsums.edu.cn
Zeng
Zong-Yuan
ZY
Guo
Zhu-Ming
ZM
Rao
Hui-Lan
HL
Zeng
Jing
J
Xu
Guang-Pu
GP
Zhang
Quan
Q
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53