[Individual susceptibility to hematotoxicity from benzene exposure and the genetic polymorphism of metabolic enzymes].
Benzene is one of wildly used chemicals. Long-term exposure to benzene causes hematotoxicities and further, the development of including anemia, myelodysplastic syndrome (MDS), aplastic anemia, etc., with the leukemia as the worst. People vary greatly in their susceptibility to adverse health outcomes from benzene exposure. The author reviewed the relationship between genetic polymorphism of I metabolic enzymes(CYP2E1, NQO1, MPO) and II metabolic enzymes(GST, PST) involving benzene metabolite and interindividual variation in their genetic susceptibility to hematotoxicity from benzene exposure in this paper.
Chen
Yan
Y
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Li
Guilan
G
Yin
Songnian
S
D000395:Air Pollutants, Occupational / Q000378:metabolism / Q000506:poisoning; D001554:Benzene / Q000378:metabolism / Q000506:poisoning*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000201:enzymology; D009249:NADP / Q000235:genetics; D011041:Poisoning / Q000235:genetics; D011110:Polymorphism, Genetic
D000395:Air Pollutants, Occupational; D009249:NADP; D019392:Cytochrome P-450 CYP2E1; D005982:Glutathione Transferase; D001554:Benzene