New palladium(II)-catalyzed asymmetric 1,2-dibromo synthesis.
[reaction: see text] The oxidation of olefins by chiral monometallic and bimetallic Pd(II)-Cu(II) catalysts in bromide-containing aqueous-THF reaction mixtures produced chiral 1,2-dibromides. With alpha-olefins, the ee's were about 95% while most of the internal alkenes gave somewhat lower enantioselectivities ( approximately 80%).
El-Qisairi
Arab K
AK
Department of Chemistry, Loyola University of Chicago, Chicago, Illinois 60626, USA.
Qaseer
Hanan A
HA
Katsigras
George
G
Lorenzi
Philip
P
Trivedi
Unnati
U
Tracz
Sylvia
S
Hartman
Amy
A
Miller
Jason A
JA
Henry
Patrick M
PM