title: [Expression of nm23-H(1) mRNA in Bone Marrow Cells from Patients with Myelodysplastic Syndrome and Its Clinical Implication]
abstract: The purpose of this investigation was to explore the expression of nm23-H(1) gene in patients with myelodysplastic syndrome (MDS) and evaluate the relationship between nm23-H(1) expression and therapeutic outcomes. Semi-quantitative RT-PCR was used to detect the expression of nm23-H(1) mRNA in marrow mononuclear cells from 28 MDS patients and 15 normal subjects. nm23-H(1)/GAPDH ratio >/= 0.5 was believed to a positive case. The expression of nm23-H(1) was positive in 24 of 28 MDS patients, and the average level was 0.89 +/- 0.56. nm23-H(1) mRNA was negative in normal controls. The overexpression of nm23-H(1) mRNA in MDS patients could predict outcome of treatment and prognosis for MDR patients.
authors.affiliation: Department of Hematology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
authors.forename: Xin-Dong
authors.initials: XD
authors.lastname: Zhao
authors.forename: Shao-Ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Zuo-Hua
authors.initials: ZH
authors.lastname: Chi
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Liu