Mesial temporal sclerosis in acute childhood leukemias.
OBJECTIVE
Although seizures are relatively common in acute childhood leukemias, evolution into epilepsy is rare.


METHODS
We describe three patients with acute leukemias who received chemotherapy. One patient also received cranial irradiation.


RESULTS
All three developed recurrent complex partial seizures after initiation of chemotherapy. Initial neuroimaging performed in two patients was normal. Subsequent neuroimaging in all three revealed mesial temporal sclerosis.


CONCLUSIONS
The association of mesial temporal sclerosis in acute childhood leukemias has not been previously described and may be secondary to antileukemic treatment and recurrent seizures.
Goyal
Monisha
M
Department of Pediatrics, Division of Pediatric Neurology, Rainbow Babies and Children's Hospital, Cleveland, OH 44106-6005, USA. mongoyal98@yahoo.com
Bangert
Barbara A
BA
Wiznitzer
Max
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy; D002648:Child; D004292:Dominance, Cerebral / Q000502:physiology; D017029:Epilepsy, Complex Partial / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy*; D012598:Sclerosis; D013702:Temporal Lobe / Q000187:drug effects* / Q000473:pathology