title: [Effect of Chinese bushen huatan drugs on pituitary-sex gland-immune axis in smoking induced chronic bronchitis mice].
abstract: OBJECTIVE
  To study the effect of Chinese Bushen Huatan Drugs (BSHT, Chinese drugs for Kidney tonifying and phlegm resolving) on pituitary-sex gland-immune axis in smoking induced mice model of chronic bronchitis.
  
  
  METHODS
  Model mice were induced by smoking and divided into the model control group, the large dosage of BSHT group, the small dosage of BSHT group and the positive control group (treated by Guilong Kechuanning, a proved effective Chinese patent drug). A blank group of normal mice was also set for control. Serum levels of testosterone (T), luteotropic hormone (LH), interleukin-2 (IL-2), interleukin-8 (IL-8), visceral indexes of testis, epididymis and thymus were measured and microstructure of testis tissue was also observed.
  
  
  RESULTS
  As compared with those in the blank group, serum T, LH and IL-2 levels, and testis, epididymis and thymus indexes were all lower, and IL-8 level was higher in the model control group, moreover, atrophic change of testis was present in the model mice. These abnormal changes were all improved in the BSHT groups.
  
  
  CONCLUSIONS
  Smoking induced mice model of chronic bronchitis, which may cause reproductive endocrine disturbance and immunosuppression. BSHT could modulate the pituitary-sex gland-immune axis through adjusting the disturbed sex hormone, improve the pathological change of testis and enhance the immunity of organism.
authors.affiliation: Hebei Medical University, Shijiazhuang 050017.
authors.forename: Shu-ling
authors.initials: SL
authors.lastname: Wang
authors.forename: Quan-he
authors.initials: QH
authors.lastname: Zeong
mesh_terms: D000818:Animals; D029481:Bronchitis, Chronic / Q000209:etiology / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007376:Interleukin-2 / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D009490:Neurosecretory Systems / Q000187:drug effects*; D010902:Pituitary Gland / Q000276:immunology*; D011897:Random Allocation; D012907:Smoking; D013737:Testis / Q000473:pathology*; D013739:Testosterone / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D013739:Testosterone; D007986:Luteinizing Hormone