[Female fertility preservation before sterilizing treatment: contribution of ovarian tissue cryopreservation].
Longer survival after anticancer treatment has lead to concern about the long-term adverse effects. Altered fertility is of particular importance. Before sterilizing treatment, three non-exclusive methods can be proposed to preserve female fertility: in vitro fertilization followed by cryopreservation of embryos, cryopreservation of mature ovocytes, cryopreservation of ovarian tissue. The method or methods chosen will depend on the age of the patient, here marital status, the urgency of the treatment, and the type of disease. Embryo cryopreservation is a routine practice in medically assisted reproduction centers, while cryopreservation of mature ovocytes and ovarian tissue is still in the experimental phase. It is known however that mature ovocytes can be used after cryopreservation. Cyropreservation of ovarian tissue is a more difficult problem. To date, there have not been any pregnancies or births after freezing-thawing of human ovarian tissue. This tissue could be used in two ways: autograft and in vitro folliculo-ovocyte maturation. Despite the uncertainty concerning use, women cryopreservation of ovarian tissue quite well.
Poirot
C
C
Unité Fonctionnelle de Biologie de la Reproduction, Groupe Hospitalier Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris.
Martelli
H
H
Lichtblau
I
I
Dhedin
N
N
Abirached
F
F
Faraguet
C
C
Vacher-Lavenu
M-C
MC
D015925:Cryopreservation / Q000379:methods*; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D009865:Oocytes; D010053:Ovary