Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.
Hong
Jung-Ae
JA
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Chung
Seok-Hee
SH
Lee
Jong-Soo
JS
Kim
Sung-Soo
SS
Shin
Hyun-Dae
HD
Kim
Hong
H
Jang
Mi-Hyeon
MH
Lee
Taeck-Hyun
TH
Lim
Baek-Vin
BV
Kim
Young-Pyo
YP
Kim
Chang-Ju
CJ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test / Q000379:methods; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D029596:Paeonia; D010805:Physical Conditioning, Animal / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000096:biosynthesis*
D010936:Plant Extracts; D012701:Serotonin; D014365:Tryptophan Hydroxylase