title: Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.
abstract: Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
authors.affiliation: Department of Virology, University of Turku, Finland. serneje@gene.cimr.cam.ac.uk
authors.forename: Sergey
authors.initials: S
authors.lastname: Nejentsev
authors.forename: Mikko
authors.initials: M
authors.lastname: Laaksonen
authors.forename: Pentti J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernandez
authors.forename: Heather
authors.initials: H
authors.lastname: Cordell
authors.forename: Juhani
authors.initials: J
authors.lastname: Ruutiainen
authors.forename: Juhani
authors.initials: J
authors.lastname: Wikström
authors.forename: Tomi
authors.initials: T
authors.lastname: Pastinen
authors.forename: Satu
authors.initials: S
authors.lastname: Kuokkanen
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
mesh_terms: D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D018799:Intercellular Adhesion Molecule-1