title: Dosimetric verification of x-ray fields with steep dose gradients using an electronic portal imaging device.
abstract: Regions with steep dose gradients are often encountered in clinical x-ray beams, especially with the growing use of intensity modulated radiotherapy (IMRT). Such regions are present both at field edges and, for IMRT, in the vicinity of the projection of sensitive anatomical structures in the treatment field. Dose measurements in these regions are often difficult and labour intensive, while dose prediction may be inaccurate. A dedicated algorithm developed in our institution for conversion of pixel values, measured with a charged coupled device camera based fluoroscopic electronic portal imaging device (EPID), into absolute absorbed doses at the EPID plane has an accuracy of 1-2% for flat and smoothly modulated fields. However, in the current algorithm there is no mechanism to correct for the (short-range) differences in lateral electron transport between water and the metal plate with the fluorescent layer in the EPID. Moreover, lateral optical photon transport in the fluorescent layer is not taken into account. This results in large deviations (>10%) in the penumbra region of these fields. We have investigated the differences between dose profiles measured in water and with the EPID for small heavily peaked fields. A convolution kernel has been developed to empirically describe these differences. After applying the derived kernel to raw EPID images, a general agreement within 2% was obtained with the water measurements in the central region of the fields, and within 0.03 cm in the penumbra region. These results indicate that the EPID is well suited for accurate dosimetric verification of steep gradient x-ray fields.
authors.affiliation: Department of Radiotherapy, Division of Clinical Physics, Erasmus MC/Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. vieira@kfih.azr.nl
authors.forename: S C
authors.initials: SC
authors.lastname: Vieira
authors.forename: M L P
authors.initials: ML
authors.lastname: Dirkx
authors.forename: K L
authors.initials: KL
authors.lastname: Pasma
authors.forename: B J M
authors.initials: BJ
authors.lastname: Heijmen
mesh_terms: D004867:Equipment Design; D005373:Film Dosimetry; D006801:Humans; D019047:Phantoms, Imaging; D011786:Quality Control; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013819:Thermoluminescent Dosimetry; D014867:Water; D014965:X-Rays
chemical_list: D014867:Water