title: Construct and predictive validity of clinical caries diagnostic criteria assessing lesion activity.
abstract: Even though there is no "gold standard" for determining caries lesion activity, it is nonetheless possible to evaluate the validity of such diagnostic measures. The aim of this study was to estimate the construct and predictive validity of caries lesion activity assessments by means of their ability to reflect known effects of fluoride on caries. A three-year trial of the effect of daily supervised brushing with fluoride toothpaste was carried out among 273 12-year-old children. All children were examined clinically according to diagnostic criteria for activity assessment. The relative risk (fluoride vs. control) for caries lesion transitions among diagnostic categories was calculated. Fluoride inhibited progression of caries at all stages of lesion formation while at the same time enhancing lesion regression. The effects were most pronounced for active non-cavitated lesions. It is concluded that the clinical diagnostic criteria have construct and predictive validity for the assessment of caries lesion activity.
authors.affiliation: Royal Dental College, Faculty of Health Sciences, University of Aarhus, Vennelyst Boulevard 9, DK-8000 Aarhus C, Denmark. nyvad@odont.au.dk
authors.forename: B
authors.initials: B
authors.lastname: Nyvad
authors.forename: V
authors.initials: V
authors.lastname: Machiulskiene
authors.forename: V
authors.initials: V
authors.lastname: Baelum
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000175:diagnosis / Q000517:prevention & control; D003732:Dental Caries Activity Tests; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D009067:Mouthwashes; D011237:Predictive Value of Tests; D012306:Risk; D014099:Toothbrushing; D014100:Toothpastes / Q000737:chemistry
chemical_list: D002327:Cariostatic Agents; D009067:Mouthwashes; D014100:Toothpastes; D005459:Fluorides