Catalytic carbonylation of functionalized diamines: application to the core structure of DMP 323 and DMP 450.
W(CO)(6)-catalyzed carbonylation provides an alternative to phosgene or phosgene derivatives such as 1,1-carbonyldiimidazole (CDI) for the conversion of amines to ureas. As an illustration, the core structure of the HIV protease inhibitors DMP 323 and DMP 450 has been prepared by catalytic carbonylation of diamine intermediates from the original syntheses.
Hylton
Keisha-Gay
KG
Department of Chemistry and Center for Catalysis, University of Florida, Gainesville, Florida 32611-7200, USA.
Main
A Denise
AD
McElwee-White
Lisa
L
D001381:Azepines / Q000138:chemical synthesis*; D017554:Carbon Compounds, Inorganic / Q000737:chemistry; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D015394:Molecular Structure; D014414:Tungsten / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D001381:Azepines; D017554:Carbon Compounds, Inorganic; D003959:Diamines; D017320:HIV Protease Inhibitors; C434643:hexacarbonyltungsten; D014508:Urea; C085816:DMP 323; D014414:Tungsten; C099851:DMP 450