Increased interleukin-6 in aqueous humor of a patient with lung-metastatic intraocular adenocarcinoma.
OBJECTIVE
We report increased interleukin (IL)-6 level in aqueous humor of a case of lung adenocarcinoma with metastasis to iris and anterior chamber.


METHODS
Interventional case report.


METHODS
In one case and 11 healthy cataract patients as controls, we checked the levels of IL-6, IL-2, and tumor necrosis factor (TNF)-alpha in aqueous humor and serum by enzyme-linked immunosorbent assay.


RESULTS
Levels of these three cytokines in serum were almost the same as with the levels in aqueous humor in the control group. The IL-6 concentrations ranged from 12.6 to 27.0 pg/ml (mean, 23.5 pg/ml) in serum and 15.0 to 43.1 pg/ml (mean, 22.4 pg/ml) in aqueous humor. There was no statistically significant difference between them. Compared with the control, the IL-6 concentration in aqueous humor of this patient, 282.0 pg/ml, increased more than 10-fold.


CONCLUSIONS
This is a report describing elevated IL-6 level in the aqueous humor of a patient with intraocular metastasis from lung adenocarcinoma.
Chen
Ko-Hua
KH
Department of Ophthalmology, Taipei Veterans General Hospital, Section II, Taipei, Taiwan, Republic of China. khchen@vghtpe.gov.tw
Hsu
Wen-Ming
WM
Wu
Chih-Chiau
CC
D000230:Adenocarcinoma / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology / Q000528:radiation effects; D001082:Aqueous Humor / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D015811:Iris Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha