title: Vital exhaustion in relation to lifestyle and lipid profile in healthy women.
abstract: "Vital exhaustion," characterized by fatigue, irritability, and demoralization, precedes new and recurrent coronary events. Biological mechanisms explaining this association are not fully understood. The objective was to investigate the relationship between vital exhaustion, lifestyle, and lipid profile. Vital exhaustion, smoking, body mass index (BMI), alcohol consumption, exercise capacity, and serum lipids were determined in 300 healthy women, aged 56.4 +/- 7.1 years. No statistically significant associations were found between vital exhaustion and lifestyle variables. Divided into quartiles, vital exhaustion was inversely related to high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 in a linear fashion after adjustment for age, BMI, exercise capacity, and alcohol consumption. A multivariate-adjusted vital exhaustion-score in the top quartile, as compared to one in the lowest, was associated with 12% lower HDL-C and 8% lower apolipoprotein A1 (p < .05). In conclusion, alterations in lipid metabolism may be a possible mediating mechanism between vital exhaustion and coronary heart disease. The impact of lifestyle variables was weak.
authors.affiliation: Preventive Medicine, Department of Public Health Sciences, Karolinska Institute, Stokholm, Sweden. Jenny.Koertge@smd.sll.se
authors.forename: Jenny C
authors.initials: JC
authors.lastname: Koertge
authors.forename: Staffan
authors.initials: S
authors.lastname: Ahnve
authors.forename: Karin
authors.initials: K
authors.lastname: Schenck-Gustafsson
authors.forename: Kristina
authors.initials: K
authors.lastname: Orth-Gomer
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Wamala
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D016632:Apolipoprotein A-I / Q000097:blood*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D005221:Fatigue / Q000523:psychology*; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D012307:Risk Factors; D013315:Stress, Psychological
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL