title: Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy.
abstract: The case is described of a 20-year-old man with adrenoleukodystrophy who showed right spastic hemiparesis and gait disturbance. Brain magnetic resonance imaging disclosed predominant involvement of the left corticospinal pathway. The clinical symptoms improved after bone marrow transplantation. Transcranial magnetic stimulation disclosed significant improvement in various parameters of central motor conduction.
authors.affiliation: Department of Neurology, Kyoto University Hospital, Japan. hitomi46@kuhp.kyoto-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Hitomi
authors.forename: T
authors.initials: T
authors.lastname: Mezaki
authors.forename: T
authors.initials: T
authors.lastname: Tsujii
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Tomimoto
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Shimohama
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
authors.forename: T
authors.initials: T
authors.lastname: Uchiyama
authors.forename: H
authors.initials: H
authors.lastname: Shibasaki
mesh_terms: D000326:Adrenoleukodystrophy / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D004338:Drug Combinations; D004525:Efferent Pathways / Q000503:physiopathology*; D055590:Electromagnetic Phenomena / Q000379:methods; D004883:Erucic Acids / Q000627:therapeutic use; D019054:Evoked Potentials, Motor / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D010291:Paresis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome; D014304:Triolein / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D004883:Erucic Acids; C079420:Lorenzo's oil; D014304:Triolein