[Study of sesquiterpene alkaloids from Tripterygium wilfordii Hook.f].
OBJECTIVE
To study the chemical composition of Tripterygium wilfordii Hook.f.


METHODS
Column chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR, 13CNMR (COM and OFR), 1H-1H COSY, 1H-13C COSY, 2D-NOESY and 1H-13C COLOC were used to determine the structures of the isolated constituents.


RESULTS
Two sesquiterpene alkaloids were isolated and their structures were elucidated as euonine and wilfordconine on the basis of spectral evidence.


CONCLUSIONS
Wilfordconine, a new sesquiterpene alkaloid, was shown to be immunosuppressive.
Lin
S
S
Fujian Institute of Medical Sciences, Fuzhou 350001, China.
Li
Y C
YC
Sakurai
N
N
Lin
J F
JF
Jin
J J
JJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020014:K562 Cells / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029757:Tripterygium / Q000737:chemistry*
D000470:Alkaloids; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; C475963:wilfordconine; C062678:euonine