[Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].
OBJECTIVE
To study the effect of tanshinone IIA on liver fibrosis in rats induced by CCl4.


METHODS
Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.


RESULTS
Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.


CONCLUSIONS
Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.
Liu
Yonggang
Y
First Military Medical University, Guangzhou 510515.
Chen
Houchang
H
Jiang
Yiping
Y
D045784:Abietanes; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism / Q000473:pathology*; D010616:Phenanthrenes / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D045784:Abietanes; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C021751:tanshinone