title: Allergen-independent maternal transmission of asthma susceptibility.
abstract: Maternal asthma is a risk factor for development of asthma in children, but mechanisms remain unclear. Offspring of asthmatic mother mice (sensitized and repeatedly exposed to OVA Ag) showed airway hyperresponsiveness and allergic pulmonary inflammation after an intentionally suboptimal OVA sensitization and exposure protocol that had little effect on normal offspring. Similar results were obtained when offspring of OVA-allergic mothers were exposed to an unrelated allergen, casein, indicating that the maternal effect is allergen independent and not transferred by OVA-specific Abs. Premating treatment with neutralizing anti-IL-4 Ab or reduction of maternal allergen exposure abrogated the maternal effect, showing a critical mechanistic role for IL-4 and suggesting an additional benefit of allergen avoidance.
authors.affiliation: Nara Medical University, Nara, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hamada
authors.forename: Yasue
authors.initials: Y
authors.lastname: Suzaki
authors.forename: Alejandra
authors.initials: A
authors.lastname: Goldman
authors.forename: Yao Yu
authors.initials: YY
authors.lastname: Ning
authors.forename: Carroll
authors.initials: C
authors.lastname: Goldsmith
authors.forename: Aiyappa
authors.initials: A
authors.lastname: Palecanda
authors.forename: Brent
authors.initials: B
authors.lastname: Coull
authors.forename: Cedric
authors.initials: C
authors.lastname: Hubeau
authors.forename: Lester
authors.initials: L
authors.lastname: Kobzik
mesh_terms: D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000918:Antibody Specificity; D001249:Asthma / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002364:Caseins / Q000008:administration & dosage / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007274:Injections, Intraperitoneal; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008807:Mice, Inbred BALB C; D009035:Mothers; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000473:pathology / Q000503:physiopathology
chemical_list: D000336:Aerosols; D000485:Allergens; D002364:Caseins; D000939:Epitopes; D007073:Immunoglobulin E; D010047:Ovalbumin