title: Treatment of painful peripheral neuromas by vein implantation.
abstract: Firstly, we designed a vein-implantation model using the rat femoral nerve and vein to study the morphometric changes in nerve endings inserted into venous lumina. By 4 weeks, nerve fibers had extended from the nerve stump into the lumen of the vein and along the endothelium of the vein. After 8 weeks, the lengths and number of nerve fibres extending into the vein lumen began to decrease. At 12 weeks, the nerve ending had developed a hemispherical shape. In none of the experiments was a neuroma formed. Secondly, we treated ten neuromas in ten patients by the vein-implantation method. We obtained excellent results in seven patients.
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shougoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. kakinoki@kuhp.kyoto-u.ac.jp
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kakinoki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Ikeguchi
authors.forename: Taiichi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Shimizu
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005267:Femoral Nerve / Q000293:injuries*; D005268:Femoral Vein / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009416:Nerve Regeneration; D009463:Neuroma / Q000175:diagnosis / Q000601:surgery*; D010147:Pain Measurement; D010148:Intractable Pain / Q000175:diagnosis / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014680:Veins / Q000637:transplantation*; D014945:Wound Healing / Q000502:physiology