title: Renal cell carcinoma, chromophobe type, with collecting duct carcinoma and sarcomatoid components.
abstract: We report a case of a 72-year-old man with a chromophobe renal cell carcinoma that had both sarcomatoid and collecting duct carcinoma components. The 7-cm tumor occupied the entire lower pole of the kidney and infiltrated the renal parenchyma and the pelvic-calyceal system. Histologically, it had an area of classic chromophobe renal cell carcinoma that merged into a sarcomatoid component. Closely intermixed with the sarcomatoid component was a collecting duct carcinoma component characterized by highly pleomorphic, epithelioid cells arranged in cords, nests, and tubulomicrocystic structures. The cords, nests, and tubules were associated with a florid desmoplastic stromal response and numerous inflammatory cells. In addition, dysplastic changes were noted in adjacent nonneoplastic collecting duct epithelium. Immunohistochemical studies confirmed the presence of 3 distinct components in this patient's tumor. To the best of our knowledge, this is the first reported case of a chromophobe renal cell carcinoma with sarcomatoid and collecting duct carcinoma components.
authors.affiliation: Department of Pathology, Northwestern University Medical School, Chicago, Ill 60611, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Gong
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Sun
authors.forename: G Kenneth
authors.initials: GK
authors.lastname: Haines
authors.forename: Michael R
authors.initials: MR
authors.lastname: Pins
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D007685:Kidney Tubules, Collecting / Q000473:pathology; D008297:Male; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology