title: Prenatal genetic testing by amniocentesis appears to result in a lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Eight hundred twenty-eight patients with singleton gestations achieved by ICSI.
  
  
  METHODS
  Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients).
  
  
  METHODS
  Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight.
  
  
  RESULTS
  A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 g (8.2% vs. 4.6%, respectively).
  
  
  CONCLUSIONS
  Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI.
authors.affiliation: Centre for Reproductive Medicine, University Hospital and Medical School, Dutch-Speaking Brussels Free University, Brussels, Belgium. stratis@easynet.be
authors.forename: Efstratios
authors.initials: E
authors.lastname: Kolibianakis
authors.forename: Kaan
authors.initials: K
authors.lastname: Osmanagaoglu
authors.forename: Luc
authors.initials: L
authors.lastname: De Catte
authors.forename: Michel
authors.initials: M
authors.lastname: Camus
authors.forename: Maryse
authors.initials: M
authors.lastname: Bonduelle
authors.forename: Inge
authors.initials: I
authors.lastname: Liebaers
authors.forename: Andre
authors.initials: A
authors.lastname: Van Steirteghem
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
mesh_terms: D000022:Abortion, Spontaneous / Q000517:prevention & control*; D000328:Adult; D000649:Amniocentesis / Q000592:standards*; D015193:Chorionic Villi Sampling / Q000592:standards*; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure