[Study on animal models for hyperlipidemia].
To establish a better animal model for hyperlipidemia, three animal models with SD rats, Wistar rats and golden hamsters were explored. The semi-purified diet for rats was composed of 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. The semi-purified diet for hamster was composed of 0.2% cholesterol, 15% lard and 85% normal diet. Serum TC, TG, HDL-C, liver cholesterol and triglyceride were assayed. Serum TG of SD rat, Wistar rat and hamster was 194.4%, 86.2% and 84.3% respectively higher than that of control after 5 weeks of experiment. Serum TC of the three groups was 76.8%, 48.3% and 134.8% respectively higher than that of control. The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be better for hypertriglyceridemia.
Gao
Ying
Y
Department of Nutrition and Food Hygiene, Beijing University, Beijing 100083, China.
Li
Keji
K
Tang
Shiying
S
Xiao
Ying
Y
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D006949:Hyperlipidemias; D008297:Male; D008647:Mesocricetus; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013045:Species Specificity