title: Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy.
abstract: Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The authors present the case of a 7-year-old boy with an abdominal mass diagnosed as IMT with malignant transformation. The tumor recurred twice after attempts at resection and was initially treated with vincristine and etoposide. After a third recurrence and incomplete resection, he was treated with cisplatin, Adriamycin, and methotrexate. He is disease-free after 2 years, representing successful combined surgery and chemotherapy in the treatment of malignant IMT. The use of chemotherapy for aggressive myofibroblastic tumors is reviewed.
authors.affiliation: Department of Pathology, University of Kentuckey Children's Hospital/Chandler Medical Center, Lexington, USA.
authors.forename: Megan K
authors.initials: MK
authors.lastname: Dishop
authors.forename: Brad W
authors.initials: BW
authors.lastname: Warner
authors.forename: Louis P
authors.initials: LP
authors.lastname: Dehner
authors.forename: Vesna M
authors.initials: VM
authors.lastname: Kriss
authors.forename: Martha F
authors.initials: MF
authors.lastname: Greenwood
authors.forename: John D
authors.initials: JD
authors.lastname: Geil
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Moscow
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic; D002648:Child; D006801:Humans; D007249:Inflammation; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery*; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome