Platelet serotonin transporter in stroke patients.
OBJECTIVE
Post-stroke depression can be treated with serotonin transport inhibitors suggesting a role for the serotonin system in these patients. The number of platelet serotonin transporters in stroke patients and in control subjects have been measured in this study.


METHODS
Newly admitted stroke patients who did develop or who did not develop a post-stroke depression, non-acute patients who previously had had a stroke and control subjects were compared. The number of platelet serotonin transporters was analysed by ligand binding methodology.


RESULTS
The number of platelet serotonin transporters was low shortly after a stroke compared with normal subjects; no difference was found between the stroke patients who developed a post-stroke depression and those who did not.


CONCLUSIONS
A low number of platelet serotonin transporters may be a non-specific state marker for a condition as acute stroke.
Rasmussen
A
A
Department of Psychiatry, Copenhagen University Hospital, Frederiksberg, Denmark.
Christensen
J
J
Clemmensen
P M
PM
Dalsgaard
N J
NJ
Dam
H
H
Hindberg
I
I
Lunde
M
M
Plenge
P
P
Mellerup
E
E
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000494:pharmacology; D001667:Binding, Competitive; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins / Q000096:biosynthesis*; D002908:Chronic Disease; D003863:Depression / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D017374:Paroxetine / Q000493:pharmacokinetics; D012016:Reference Values; D050486:Serotonin Plasma Membrane Transport Proteins; D020521:Stroke / Q000150:complications / Q000378:metabolism*; D013997:Time Factors
D015415:Biomarkers; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D017374:Paroxetine; D001241:Aspirin