title: Unique bioconcentration characteristics of new aryl fluoroalkyl ethers in common carp (Cyprinus carpio).
abstract: The bioconcentration factors (BCFs) of seven new aryl fluoroalkyl ethers--four bis-4-tetrafluoroethoxyphenyl-type (bis-type) compounds and three mono-4-tetrafluoroethoxyphenyl-type (mono-type) compounds--were obtained by bioconcentration tests using common carp. The BCFs of 4 of the 7 ethers were higher than 5000, indicating their high bioconcentration potential. The bioconcentration characteristics of the bis-type compounds were different from those of the mono-type compounds and non-fluoro diphenylmethanes with a similar skeleton structure to the bis-type compounds, in taking longer to reach a plateau and having a slower elimination rate and in their distribution patterns in the fish body. The BCF of 1 bis-type compound was much higher than the value predicted by an accepted correlation equation between BCF and P(ow). In addition, the logP(ow) of the bis-type compounds calculated by commercially available computer software was remarkably different from that measured.
authors.affiliation: Chemicals Evaluation and Research Institute, Kurume Laboratory, 19-14 Chuo-machi, Kurume, Fukuoka 830-0023, Japan. yakata-noaki@ceri.jp
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yakata
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sudo
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Yakabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tadokoro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fukui
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sanechika
authors.forename: Masanori
authors.initials: M
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D004987:Ethers / Q000378:metabolism*; D017611:Fluorine Compounds / Q000378:metabolism*; D012984:Software
chemical_list: D004987:Ethers; D017611:Fluorine Compounds