On the amazing olivocerebellar system.
Over the last four decades elegant sets of a single-cell studies, originating from various research groups, have contributed significantly to our understanding of olivary and cerebellar physiology. Nevertheless questions relating to the dynamic properties of olivocerebellar network, as a system, remain unsolved. We may be reaching the limits of what can be learned using the single-cell recordings. Further research on this subject may require study of the spatiotemporal activity profiles of ensemble neuronal activity. This paper summarizes results obtained using voltage-sensitive dye imaging in inferior olive slices, and the use of mathematical modeling to address such activity profiles.
Llinás
R
R
Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA. llinar01@endeavor.med.nyu.edu
Leznik
E
E
Makarenko
V I
VI
D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D009847:Olivary Nucleus / Q000502:physiology*