PLA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIa in young patients with cryptogenic TIA or ischemic stroke.
BACKGROUND
The relationship between the PIA2 allele of the Leu(33)Pro polymorphism of glycoprotein IIb/IIIa receptor (GPIIb/IIIa) and ischemic stroke is uncertain. The purpose of this study was to investigate a possible association between the GPIIb/IIIa PIA1/A2 polymorphism and the occurrence of cryptogenic stroke in young patients.


METHODS
From a consecutive series of 80 patients aged 45 or less with a recent ischemic stroke or TIA, we selected 45 patients with stroke due to small vessel occlusion or stroke of undetermined etiology (according to the TOAST criteria). Controls were 60 healthy blood donors with a similar age distribution. All patients underwent CT of the brain and were screened for cardiovascular risk factors, cardiac disorders and large vessel disease. The frequency of the PIA2 allele was determined by PCR and Msp1 restriction analysis.


RESULTS
Eight patients (16%) and 16 controls (27%) were heterozygous for PIA2 allele. Two patients (4%) were homozygous for PIA2. The relative risk of ischemic stroke associated with PIA2 allele was estimated at 0.8 (95% CI: 0.3-1.9).


CONCLUSIONS
This study does not support the association between the PIA1/A2 polymorphism and cryptogenic stroke or TIA in patients aged 45 or less.
van Goor
Mary Lou P J
ML
Department of Neurology of the Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. vangoor@neuro.fgg.eur.nl
Gómez García
Encarna
E
Brouwers
Geert-Jan
GJ
Leebeek
Frank W G
FW
Koudstaal
Peter J
PJ
Dippel
Diederik W J
DW
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000235:genetics*
D019039:Platelet Glycoprotein GPIIb-IIIa Complex