[Effects of quanjia yangshen capsule on rate of polychromatic erythrocytic micronucleus formation and peripheral blood picture in mice treated by cyclophosphamide].
OBJECTIVE
To observe the effect of Quanjia Yangshen capsule (QJYS) on cyclophosphamide (Cy) induced teratogenesis and bone marrow in mice and to explore the mechanism of its clinical therapeutic effect.


METHODS
Mice were separately administered with QJYS solely, Cy solely and QJYS + Cy and the effect on polychromatic erythrocytic (PE) micronucleus formation rate in the bone marrow of mice, and peripheral blood picture were observed and compared with the control group.


RESULTS
High dosage of QJYS has no apparent effect on PE micronucleus formation rate and peripheral blood picture in the normal mice; Cy can obviously raise PE micronucleus formation rate (P < 0.01), and lowered WBC, RBC and Hb obviously (P < 0.01) in mice. After taking QJYS, the Cy induced micronucleus formation rate increasing and blood picture parameters lowering were controlled. The improvement in the high and middle dose QJYS group was significantly higher in comparing to that in the sole Cy group (P < 0.01); while the low dose QJYS group in comparing with Cy group also showed significant improvement (P < 0.01), except Hb value.


CONCLUSIONS
QJYS could significantly antagonize teratogenic effect and inhibition to bone marrow of Cy, i.e., play an antagonistic role against the toxic and side-effects of Cy.
Ren
L S
LS
Shanxi Cancer Institute, Taiyuan 030013.
Zhang
H
H
Tang
Y
Y
D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000473:pathology; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000473:pathology*; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide