title: Large cell neuroendocrine carcinoma of the ampulla of vater.
abstract: We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery. Microscopically, the tumor was extensively necrotic. It was composed of islands and trabeculae irregularly infiltrating the muscular wall of the duodenum. Neoplastic cells were large and had a high mitotic index. Immunohistochemically, they expressed cytokeratin, chromogranin, synaptophysin, and neuron-specific enolase. Large cell neuroendocrine carcinoma is very rare in the ampulla of Vater, and it shares with its more common pulmonary counterpart the same morphology and probably the same poor prognosis.
authors.affiliation: Department of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy. cavazza.alberto@asmn.re.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Marco
authors.initials: M
authors.lastname: Gallo
authors.forename: Roberto
authors.initials: R
authors.lastname: Valcavi
authors.forename: Loredana
authors.initials: L
authors.lastname: De Marco
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gardini
mesh_terms: D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology* / Q000601:surgery; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans