title: Virus-like particles as a modular system for novel vaccines.
abstract: Induction of protective immune responses with recombinant antigens is a major challenge for the vaccine industry. Here we present a molecular assembly system that renders antigens of choice highly repetitive. Using this method, efficient antibody responses may be induced in the absence of adjuvants resulting in protection from viral infection and allergic reactions.
authors.affiliation: Cytos Biotechnology AG, Zürich, Switzerland.
authors.forename: Franziska
authors.initials: F
authors.lastname: Lechner
authors.forename: Andrea
authors.initials: A
authors.lastname: Jegerlehner
authors.forename: Alain C
authors.initials: AC
authors.lastname: Tissot
authors.forename: Patrik
authors.initials: P
authors.lastname: Maurer
authors.forename: Peter
authors.initials: P
authors.lastname: Sebbel
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Renner
authors.forename: Gary T
authors.initials: GT
authors.lastname: Jennings
authors.forename: Martin F
authors.initials: MF
authors.lastname: Bachmann
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy; D007167:Immunotherapy; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D014771:Virion / Q000276:immunology*
chemical_list: D000941:Antigens; D014765:Viral Vaccines