An unexpected adverse drug effect.
Adverse drug-drug interactions can occur between active and/or inactive ingredients in different formulations. The occurrence of a disulfiram reaction that developed postpartum following a 7-day course of metronidazole is presented. The case is presented, followed by a discussion of the mechanism of action and treatment. Recommendations for prevention of adverse drug effects are reviewed.
Krulewitch
Cara J
CJ
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002981:Clindamycin / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000009:adverse effects*; D009325:Nausea / Q000139:chemically induced*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D016585:Vaginosis, Bacterial / Q000188:drug therapy; D014839:Vomiting / Q000139:chemically induced*
D000427:Alcohol Deterrents; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008795:Metronidazole; D002981:Clindamycin