title: [Synthesis and insecticidal activity of the novel hydroxylbenzenedisulfonanilides compounds].
abstract: OBJECTIVE
  To synthesize novel derivatives of hydroxylbenzenedisulfonanilide with high insecticidal activity against the Fasciola hepatica.
  
  
  METHODS
  o-(m-, p-) Chlorphenol were used to synthesize the title compounds by sulphonation and nucleiphilic-substitution reaction. The uncoupling activity (insecticidal activity) of these compounds were tested by determining the influence on mitochondrial respiration control ratio (RCR) and the variation of inorganic phosphate in oxidative phosphorylation (delta Pi).
  
  
  RESULTS
  Compounds 1-14 are new compounds. The structures of the compounds were determined by IR, HNMR and elemental analysis. Most new compounds have relatively high uncoupling activities, especially compounds 3, 5, 6 and 9.
  
  
  CONCLUSIONS
  Compounds 3, 5, 6 and 9 will become novel fasciolicides and are worth further studying.
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China. shiyu1970@hotmail.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.forename: Ya-xin
authors.initials: YX
authors.lastname: Jiang
authors.forename: Xue-ping
authors.initials: XP
authors.lastname: Niu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xin
mesh_terms: D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005210:Fasciola hepatica / Q000187:drug effects; D008930:Mitochondria, Liver / Q000502:physiology; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000813:Anilides; D000871:Anthelmintics; D013449:Sulfonamides