Remission of a cutaneous Mycosis fungoides after topical 5-ALA sensitisation and photodynamic therapy in a patient with advanced HIV-infection.
BACKGROUND
Treatment of Mycosis fungoides (MF) in HIV-infected patients is controversially discoursed. Photodynamic therapy (PDT) after topical sensitization with 5-aminolevulinic acid (5-ALA) is a new and effective modality for treatment of skin malignancies.


OBJECTIVE
In this report we describe, what is, to our knowledge, the first case of a patient with MF through advanced HIV-infection, successfully experiencing topical 5-ALA sensitization and PDT.


METHODS
5-ALA ointment was applied to plaques and held in occlusion for 4 hours. PDT was applied using the PDT 1200 irradiation source (Waldmann Medizintechnik System) with 180 J/cm superset 2.


RESULTS
Complete remission of MF was achieved, after two completed cycles of photodynamic therapy.


CONCLUSIONS
MF lesions in the presended case showed a high response to 5-ALA sensitization and PDT. This modality appeared to be very effective in treatment of MF in a HIV-infected patient and could be a valuable treatment option for cutaneous T-cell lymphoma in HIV-infected patients.
Paech
V
V
Ifi-institute for interdisciplinary Infectiology and Immunology GmbH, Hamburg, Germany.
Lorenzen
T
T
Stoehr
A
A
Lange
K
K
Merz
H
H
Meigel
W N
WN
Plettenberg
Andreas
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000821:virology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000821:virology; D014467:Ultraviolet Therapy
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid