[Effect of Jingtian compound on the delay of skin aging].
In order to study whether Jingtian compound extracted from herbs could delay the process of skin aging, the skin on the back of Guinea pigs (6 and 15 months old) were shaved topically and applied with and without 0.5% Jingtian compound for 30 days by self-control design. The possible alterations caused by Jingtian compound were observed by histological and biochemical techniques. Results showed that the number and the activity of fibroblast in dermis was increased prominently compared with the control. The activities of superoxide dismutase, glutathion peroxidase and the hydroxyproline level of acid soluble collagen in dermis were enhanced, and the malondialdehyde content was inhibited concomitantly. It is suggested that Jingtian compound might play a protective role on skin aging.
Guan
Yingjie
Y
Institute of Preventive Medicine, Fudan University, Shanghai 200032, China.
Jin
Xipeng
X
Wei
Shaomin
S
Lin
Huifen
H
D000818:Animals; D003094:Collagen / Q000378:metabolism; D003358:Cosmetics; D029627:Crassulaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D012867:Skin / Q000737:chemistry*; D015595:Skin Aging / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
D003358:Cosmetics; D004365:Drugs, Chinese Herbal; D003094:Collagen; D013482:Superoxide Dismutase