[Simultaneous determination of four components in the compound child phenobarbital tablet using ultraviolet spectrophotometry].
OBJECTIVE
To establish a method to determine four components in the child phenobarbital tablet.


METHODS
Ultraviolet spectrophotometry was used to determine four components without separation.


RESULTS
The contents of aspirin, phenacetin, caffeine and phenobarbital could be measured simultaneously. The average recoveries of four components in simulated samples and the compound child phenobarbital tablet samples were 99.0%, 98.9%, 99.8%, and 101%, respectively, and relative standard deviations of those were 2.0%, 2.0%, 2.9%, and 2.2%, respectively.


CONCLUSIONS
The method is simple, fast, reliable, and can be used to monitor the quality of compound drugs.
Wen
Li
L
Department of Chemistry, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Fang
Hui-hui
HH
D001241:Aspirin / Q000032:analysis*; D002110:Caffeine / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004339:Drug Compounding; D006801:Humans; D007223:Infant; D010615:Phenacetin / Q000032:analysis*; D010634:Phenobarbital / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D013607:Tablets; D002110:Caffeine; D010615:Phenacetin; D001241:Aspirin; D010634:Phenobarbital