title: The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.
abstract: The combination therapy of a Kampo formula and an analgesic-antipyretic agent is often used for the common cold in Japan. We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress. The combination therapy of Ephedra herb and Loxoprofen caused gastric mucosal lesions and loss of body weight. It is considered that this combination therapy should be avoided because of its adverse effects.
authors.affiliation: Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. cho-tky@umin.ac.jp
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Cho
authors.forename: Tie
authors.initials: T
authors.lastname: Hong
authors.forename: Guang-Bi
authors.initials: GB
authors.lastname: Jin
authors.forename: Gen
authors.initials: G
authors.lastname: Yoshino
authors.forename: Myota
authors.initials: M
authors.lastname: Miura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Aikawa
authors.forename: Fumiko
authors.initials: F
authors.lastname: Yasuno
authors.forename: Jong-Chol
authors.initials: JC
authors.lastname: Cyong
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D029789:Ephedra / Q000633:toxicity*; D005334:Fever / Q000503:physiopathology; D005753:Gastric Mucosa / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009584:Nitrogen / Q000378:metabolism; D010666:Phenylpropionates / Q000633:toxicity*; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D013315:Stress, Psychological / Q000503:physiopathology; D014527:Uric Acid / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D014527:Uric Acid; C040656:loxoprofen; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D009584:Nitrogen