title: Effect of perioperative oral carprofen on postoperative pain in dogs undergoing surgery for stabilization of ruptured cranial cruciate ligaments.
abstract: A randomized, placebo-controlled, parallel study was conducted to investigate the effectiveness of oral carprofen for the control of postoperative pain in dogs undergoing knee surgery for stabilization of ruptured cranial cruciate ligaments. Dogs were randomly assigned to treatment with carprofen (n = 10) or placebo (n = 9). Pain was assessed at 1, 2, 4, 6, 24, and 48 hours and 10 and 21 days postoperatively. Eight of 10 dogs treated with carprofen and five of nine dogs treated with placebo were given at least one dose of morphine as rescue therapy. The mean relative dose of morphine given at 1 hour (P =.01) and 24 hours (P =.02) after surgery was greater for dogs treated with carprofen than for dogs given a placebo. There were no significant postoperative differences in cortisol levels or any measured variable. It appears that the scoring system used was not sensitive enough to detect differences in pain between a known analgesic and a placebo.
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Gaynor
authors.forename: Sean
authors.initials: S
authors.lastname: Brevard
authors.forename: Craig
authors.initials: C
authors.lastname: Mallinckrodt
authors.forename: Geri
authors.initials: G
authors.lastname: Baker
authors.forename: Kathy
authors.initials: K
authors.lastname: Wander
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs / Q000293:injuries / Q000601:surgery; D007430:Intraoperative Care / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy* / Q000473:pathology; D012421:Rupture / Q000601:surgery / Q000662:veterinary; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen