Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats.
The present study evaluated the beneficial effect of aqueous extract of garlic (Allium sativum L.; 100mg/kg/day) on the alterations in vascular reactivity of streptozotocin-diabetic rats. After 8 weeks of treatment, thoracic aortic rings of rats were mounted in organ baths and contractile responses to phenylephrine and relaxant responses to acetylcholine and isosorbide dinitrate were assessed. Induction of diabetes significantly increased contractile responses to phenylephrine and impaired endothelium-dependent relaxations to acetylcholine in aortic rings, but did not change endothelium-independent relaxation to isosorbide dinitrate. Garlic administration significantly improved the impaired endothelium-dependent relaxations and decreased the enhanced contractile response to phenylephrine in diabetic rats. It is concluded that intraperitoneal administration of aqueous garlic extract can improve endothelial dysfunction in insulin-dependent model of uncontrolled diabetes.
Baluchnejadmojarad
Tourandokht
T
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Hemmat Expressway, Tehran 14155-6183, Iran. tmojarad@yahoo.com
Roghani
Mehrdad
M
Homayounfar
Homayoun
H
Hosseini
Mahmoud
M
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D005737:Garlic; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D014867:Water
D001786:Blood Glucose; D010936:Plant Extracts; D014867:Water