[Perspective study on effect of gandou tablet I on biliary trace elements in treating hepatolenticular degeneration].
OBJECTIVE
To observe the effect of gandou tablet I (GDI), a Chinese herbal recipe, on the content of biliary trace elements in hepatolenticular degeneration(HLD) patients.


METHODS
Before and after 4 weeks treatment by oral taken GDI, bile of 32 cases of HLD were collected by duodenal drainage for determining biliary trace elements, including copper, zinc, iron and calcium, by spectrophotometer of atom absorption spectrum, and compared with those of 30 cases of non-HLD patients as the control.


RESULTS
The contents of copper, iron and copper/zinc ratio were obviously lower, while the content of calcium greatly higher (P < 0.01), in the HLD group before GDI treatment than those in the control (P < 0.01 or P < 0.05), but the content of zinc was not significantly different between the two groups. The output of biliary copper after GDI treatment was significantly increased compared with that before treatment (P < 0.05), but the contents of zinc, iron, calcium and copper/zinc ratio were not markedly changed.


CONCLUSIONS
The impediment to output of biliary copper was one of the mechanisms for copper storage in body of HLD patients. GDI could promote excretion of biliary copper in the HLD patients.
Hu
W B
WB
Institute of Neurology, Anhui College of TCM, Hefei 230031.
Yang
R M
RM
D000293:Adolescent; D000328:Adult; D001646:Bile / Q000378:metabolism*; D002648:Child; D003300:Copper / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D011446:Prospective Studies; D013607:Tablets; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013607:Tablets; D014131:Trace Elements; D003300:Copper; D007501:Iron; D015032:Zinc