Monoamine oxidase and cigarette smoking.
Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation.
Fowler
Joanna S
JS
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov
Logan
Jean
J
Wang
Gene-Jack
GJ
Volkow
Nora D
ND
D000818:Animals; D001921:Brain / Q000201:enzymology; D006801:Humans; D001523:Mental Disorders / Q000201:enzymology / Q000523:psychology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D012907:Smoking / Q000453:epidemiology / Q000378:metabolism* / Q000523:psychology; D016540:Smoking Cessation / Q000523:psychology
D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase