title: [Detection of chromosome 8 anomalies in ovarian carcinoma by fluorescence in situ hybridization].
abstract: OBJECTIVE
  To detect the relationship between chromosomal anomalies and the pathogenesis, development and prognosis of ovarian carcinoma.
  
  
  METHODS
  Thirty-six specimens of ovarian carcinoma (n=12), ovarian benign tumor (n=12), and normal ovary (n=12) were examined by fluorescence in situ hybridization (FISH).
  
  
  RESULTS
  Twelve cases of mutations, including trisomy 8, monosomy 8 or tetraploid 8 chromosomal anomalies, were found in the group of ovarian carcinoma, making up 100% (12/12). Three cases of trisomy 8 chromosomal anomalies were found in the group of ovarian benign tumor, accounting for 25% (3/12). No anomaly was found in the normal group. There were significant differences between the three groups, P<0.001.
  
  
  CONCLUSIONS
  The above anomalies of chromosome 8 are significantly associated with the pathogenesis and development of ovarian carcinoma. The anomalies may occur in the early stage of the carcinoma, and may be significantly associated with the pathological differentiation and clinical stage of the case.
authors.affiliation: Department of Gynecology, the First People's Hospital of Yunnan Province, Kunming, PR China.
authors.forename: Yue-lan
authors.initials: YL
authors.lastname: Dong
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Li
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Chen
authors.forename: Huai-ying
authors.initials: HY
authors.lastname: Feng
authors.forename: Bao-sheng
authors.initials: BS
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008875:Middle Aged; D009006:Monosomy; D010051:Ovarian Neoplasms / Q000235:genetics*; D014314:Trisomy