[Animal experimental study of effects of long-term triamcinolone acetonide acetate nasal spray on the nasal mucosa].
OBJECTIVE
To explore the effects of triamcinolone acetonide acetate nasal spray on the animal's nasal mucosa.


METHODS
Animals were divided into three groups: group one for high dosage; group two for low dosage; group three for control. Animals were given the high dosage of triamcinolone acetonide acetate nasal spray (880 micrograms), low dosage of triamcinolone acetonide acetate nasal (220 micrograms), 0.9% saline solution spray for each nasal cavity for two months. Before and after drug spraying, the examination of nasal mucosa and the blood routine were made, and the middle and inferior turbinate were removed for light and electron microscopic examination.


RESULTS
No differences of blood routine and nasal mucosa can be seen among the three groups, and the light and electron microscopic examination also.


CONCLUSIONS
No harmful effects of triamcinolone acetonide acetate nasal spray on the nasal mucosa for long time using can be seen on the animal's experiment.
Zhai
Suoqiang
S
Institute of Otorhinolaryngology of PLA General Hospital, Beijing 100853.
Cao
Juyang
J
Sun
Jianhe
J
Yang
Weiyan
W
D000281:Administration, Intranasal; D000818:Animals; D004285:Dogs; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide