title: [Study on water of crystallization in tazobactam].
abstract: OBJECTIVE
  To investigate whether tazobctam has crystallization water.
  
  
  METHODS
  In order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied.
  
  
  RESULTS
  The water content of the same batch tazobactam determined by different mthods was different.
  
  
  CONCLUSIONS
  The results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.
authors.affiliation: Jiangsu Province Institute of Drug Control, Nanjing 210008, China.
authors.forename: Yao-zuo
authors.initials: YZ
authors.lastname: Yuan
authors.forename: Chang-qin
authors.initials: CQ
authors.lastname: Hu
authors.forename: Shao-hong
authors.initials: SH
authors.lastname: Jin
mesh_terms: D003460:Crystallization; D004791:Enzyme Inhibitors / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D000078142:Tazobactam; D014867:Water; D014961:X-Ray Diffraction; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D014867:Water; D010397:Penicillanic Acid; D001618:beta-Lactamases; D000078142:Tazobactam