[Effect of stilbene polymer (Gn-3) on experimental liver injuries in mice].
OBJECTIVE
To study the protective effect of Gn-3 (a stilbene polymer isolated from Gnetum parvifolium) against liver injury induced by CCl4, N-acetyl-p-aminophenol (APAP) and Bacillus Calmette-Guerin (BCG) plus bacterial lipopolysaccharide (LPS) in mice.


METHODS
The experimental model of liver injury were induced by 0.1% CCl4 i.p. (10 mL.kg-1.d-1 for 3d), APAP i.p. (150 mg.kg-1) or BCG (5 mg) plus LPS (7.5 micrograms) in mice. The levels of ALT in serum, MDA and GSH in liver tissues were detected. The histopathologic changes were observed by light microscope.


RESULTS
Gn-3 was shown to markedly reduce the elevated serum ALT levels, liver tissue MDA and improve the histopathological changes in all the three experimental liver injury models. No effect of Gn-3 was observed on the liver GSH level in liver injury mice.


CONCLUSIONS
Gn-3 was found to inhibit the development of liver injury caused by CCl4, APAP, or BCG plus LPS. This means that Gn-3 has liver protective effects.
Hou
Y N
YN
Institute of Materia Medica, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100050, China.
Zhu
X Y
XY
Liang
X L
XL
Cheng
G F
GF
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology*; D035684:Gnetum / Q000737:chemistry; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009163:Mycobacterium bovis; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*
D008070:Lipopolysaccharides; D020011:Protective Agents; D013267:Stilbenes; D000082:Acetaminophen; D008315:Malondialdehyde; D000410:Alanine Transaminase