title: Cytopathologic and clinicopathologic features of ovarian hepatoid carcinoma. A case report.
abstract: BACKGROUND
  Hepatoid carcinoma is a rare ovarian tumor and is thought to be a different histopathologic subtype from hepatoid-type yolk sac tumor based upon its pathologic features. However, the cytopathologic characteristics of ovarian hepatoid carcinoma (OHC) have not been reported previously. We report the clinicopathologic and cytopathologic features and immunoreactivity of a case of OHC.
  
  
  METHODS
  A 36-year-old woman presented to our department with lower abdominal pain. A left ovarian tumor was found on pelvic examination, magnetic resonance imaging and computed tomography. The tumor was diagnosed as a hepatoid carcinoma of the left ovary based upon the histopathology of the surgically resected specimen. Cytopathologic specimens from a tumor touch preparation of the tumor exhibited pleomorphic tumor cells with abundant cytoplasm. The nuclei contained rough, granular chromatin and large, prominent nucleoli. Several tumor cells were multinucleated. Tumor cells were immunoreactive for alpha-fetoprotein (AFP). Hematoxylin and eosin staining revealed that the tumor cells were in a sinusoidal pattern resembling hepatocellular carcinoma without any glandular formation. The tumor cells were negative for human chorionic gonadotropin while positive for AFP, alpha-1-antitripsin, CA-125 and carcinoembryonic antigen.
  
  
  CONCLUSIONS
  Cytopathologic examination is of considerable aid in the diagnosis of OHC since cytopathologic preparations highlight the characteristic cell pleomorphism.
authors.affiliation: Department of Obstetrics and Gynecology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, Osaka 589-8511, Japan. watanabe@med.kindai.ac.jp
authors.forename: Yoh
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Masahiko
authors.initials: M
authors.lastname: Umemoto
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ueda
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Nakai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshiai
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Noda
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins