title: [Long term survival of patients with lupus nephritis].
abstract: Lupus nephritis is a clinical manifestation of Systemic Lupus Erythematosus with most prominent influence on the course of the disease. The most predictive parameters for development of renal failure are: type of hystological changes, degree of interstitial inflammation, serum creatinine concentration at the time of diagnosis and therapeutical protocols used in the treatment. Single center experience in a group of 220 lupus patients is presented in this paper. In 130 patients (59%) lupus nephritis was diagnosed by clinical and laboratory tests, while 74 kidney biopsies were performed. Proliferative type of lupus nephritis (class IV in 54% of cases and class III in 18.9%) was more frequent than the other histological types. During a long term follow up (range 1-17 years, mean 7.6 years) renal failure developed in 17 patients (24%), while 11% of patients developed uremia and required dialysis. Development of renal failure was influenced by histological changes with predominance of class IV lupus nephropathy, disseminated disease with more ARA criteria for systemic lupus erythematosus classification present at the time of kidney biopsy, more frequent lupus flares, persistence of low complement levels during the first year of follow-up and even earlier.
authors.affiliation: Department of Nephrology and Clinical Immunology, Institute of Internal Diseases, Clinical Centre, Novi Sad. nefroim@EUnet.yu
authors.forename: Igor
authors.initials: I
authors.lastname: Mitić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ilić
authors.forename: Gordana
authors.initials: G
authors.lastname: Strazmester-Majstorović
authors.forename: Dragan
authors.initials: D
authors.lastname: Spasić
authors.forename: Dejan
authors.initials: D
authors.lastname: Celić
authors.forename: Biljana
authors.initials: B
authors.lastname: Kurjacki
authors.forename: Suzana
authors.initials: S
authors.lastname: Stajnic
authors.forename: Pavle
authors.initials: P
authors.lastname: Budakov
authors.forename: Slavenka
authors.initials: S
authors.lastname: Vodopivec
authors.forename: Vladimir
authors.initials: V
authors.lastname: Sakac
authors.forename: Tatjana
authors.initials: T
authors.lastname: Djurdjević-Mirković
authors.forename: Lada
authors.initials: L
authors.lastname: Petrović
authors.forename: Slobodan
authors.initials: S
authors.lastname: Curić
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy; D008181:Lupus Nephritis / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D015996:Survival Rate