[Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure].
OBJECTIVE
To investigate the relationship between serum assymmetric dimethylarginine and blood pressure in patients with chronic renal failure.


METHODS
We examined the levels of asymmetric dimethylarginine (ADMA) in the serum and urine of 29 hemodialysis patients using the HPLC method, and assessed the relationship between serum ADMA and blood pressure.


RESULTS
The level of serum ADMA was higher, but the level of urinary ADMA was lower in the patients with chronic renal failure than those in the controls. The serum ADMA was positively related to blood pressure.


CONCLUSIONS
The accumulation of ADMA may be related to hypertension in patients with chronic renal failure.
Zhang
Wei-ru
WR
Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
Tao
Li-jian
LJ
Chen
Ben-mei
BM
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000652:urine; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D006435:Renal Dialysis
C018524:N,N-dimethylarginine; D001120:Arginine; D019001:Nitric Oxide Synthase