title: Stromal vascularization in the endometrium during adenomyosis.
abstract: In adenomyosis, the two major frequent symptoms are hypermenorrhea and dysmenorrhea. The incidence of the former is said to be high, ranging from 36 to 70%. It has been found that vascular distribution of the endometrium in adenomyosis is diversely different from fertile patients without adenomyosis. For example, hysteroscopy revealed that approximately half of the patients have abnormal vascularization. In these patients, vascular distribution was generally irregular, and vessels were thick, dilated, and/or reticular in some patients. Moreover, morphometric analysis of the endometrium revealed that in the fertile women, the mean surface area, total surface area, and total number of capillaries, all increased significantly in the secretory phase compared to the proliferative phase. In contrast, the above parameters increased in the adenomyosis group in both the proliferative phase and secretory phase compared to the fertile women. In particular, the total surface area of capillaries per mm(2) markedly rose, by 11.6 times, compared to that of the proliferative phase in the fertile women. These findings suggest that regulatory factors involved in the vascular proliferation are diversely exaggerated, and that the abnormal vascularization of the endometrium is closely related with hypermenorrhea.
authors.affiliation: Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita-city, Akita-ken 010-8543, Japan. otah@obgyn.med.akita-u.ac.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ota
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D002196:Capillaries; D004715:Endometriosis / Q000473:pathology / Q000503:physiopathology*; D004717:Endometrium / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000503:physiopathology; D008597:Menstrual Cycle; D009389:Neovascularization, Pathologic; D019001:Nitric Oxide Synthase / Q000378:metabolism
chemical_list: D019001:Nitric Oxide Synthase