title: [Analysis of the metabolite of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in rabbit].
abstract: OBJECTIVE
  To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13, 13a-tetrahydroberberine in the rabbit.
  
  
  METHODS
  Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR.
  
  
  RESULTS
  A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated.
  
  
  CONCLUSIONS
  Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
authors.affiliation: China Pharmaceutical University, Nanjing 210009, China. npfeng@citiz.net
authors.forename: N P
authors.initials: NP
authors.lastname: Feng
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhang
authors.forename: D K
authors.initials: DK
authors.lastname: An
authors.forename: X W
authors.initials: XW
authors.lastname: Han
authors.forename: W L
authors.initials: WL
authors.lastname: Huan
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001599:Berberine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism*; D001711:Biotransformation; D015394:Molecular Structure; D011817:Rabbits
chemical_list: C475967:7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine; D001599:Berberine