Temporal regulation of CD81 following retinal injury in the rat.
Following retinal injury, glial cells within the retina undergo a response that is characterized by the proliferation of astrocytes, Müller cells, and retinal pigment epithelial cells. CD81, a small membrane protein known to be involved in cell proliferation, is up-regulated after injury. This study focuses on the temporal regulation of CD81, relating the expression of this protein to glial fibrillary acidic protein (GFAP), the classic marker of gliosis. CD81 levels were elevated at 7 days after injury and remained elevated at 30 days after injury; GFAP was increased at 7 days and continued to increase until 30 days post injury. This association of CD81 with glial reactivity may provide a clue to the regulation of the proliferative response following retinal injury.
Song
Bong Keun
BK
Department of Ophthalmology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA.
Geisert
Grace R
GR
Vázquez-Chona
Felix
F
Geisert
Eldon E
EE
D000818:Animals; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000737:chemistry / Q000293:injuries* / Q000378:metabolism*; D060225:Tetraspanin 28; D013997:Time Factors
D015703:Antigens, CD; C554797:Cd81 protein, rat; D005904:Glial Fibrillary Acidic Protein; D008565:Membrane Proteins; D060225:Tetraspanin 28