title: Coordination of the random asynchronous replication of autosomal loci.
abstract: Random monoallelic expression and asynchronous replication define an unusual class of autosomal mammalian genes. We show that every cell has randomly chosen either the maternal or paternal copy of each given autosome pair, such that alleles of these genes scattered across the chosen chromosome replicate earlier than the alleles on the homologous chromosome. Thus, chromosome-pair non-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of mouse chromosomes.
authors.affiliation: Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
authors.forename: Nandita
authors.initials: N
authors.lastname: Singh
authors.forename: Farah A W
authors.initials: FA
authors.lastname: Ebrahimi
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Gimelbrant
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Ensminger
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tackett
authors.forename: Peimin
authors.initials: P
authors.lastname: Qi
authors.forename: Joost
authors.initials: J
authors.lastname: Gribnau
authors.forename: Andrew
authors.initials: A
authors.lastname: Chess
mesh_terms: D000483:Alleles; D000818:Animals; D002875:Chromosomes / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D005260:Female; D015870:Gene Expression; D018392:Genomic Imprinting; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D018035:Receptors, Odorant / Q000235:genetics; D013997:Time Factors
chemical_list: D018035:Receptors, Odorant