[Changes in sensitivity of lymphocytic leukemia P388 cells to oxidative stress and platidiam upon tumor growth].
We studied the effect of oxidative stress induced by hyperoxia, hydrogen peroxide, or menadione on mouse leukemia P388 cells at early (4 days) and late (7 days) stages of tumor growth. Oxidative stress proved to inhibit cell division and to induce apoptosis. Seven-day leukemia cells feature lower proliferative potential and higher sensitivity to oxidative stress and platidiam.
Shaposhnikova
V V
VV
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia.
Orlova
O E
OE
Kudriavtsev
A A
AA
Korystov
Iu N
IuN
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D015687:Cell Hypoxia; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002945:Cisplatin / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008811:Mice, Inbred DBA; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D014407:Tumor Cells, Cultured; D024483:Vitamin K 3 / Q000494:pharmacology
D000970:Antineoplastic Agents; D024483:Vitamin K 3; D006861:Hydrogen Peroxide; D002945:Cisplatin; D010100:Oxygen