Protein phosphatase 1 and memory: practice makes PP1 imperfect?
Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain enhanced memory formed during sub-optimal training. Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting.
Waddell
Scott
S
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. scott.waddell@umassmed.edu
D000818:Animals; D007858:Learning; D008568:Memory; D051379:Mice; D008822:Mice, Transgenic; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism* / Q000502:physiology; D054645:Protein Phosphatase 1; D015398:Signal Transduction
D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1