[Effect of isoflavone on human breast cancer cell line MCF-7 and its probable mechanism].
The effects of isoflavone on human breast cancer cell line MCF-7 growth and apoptosis and its probable mechanisms were studied in vitro. The results showed that isoflavone could significantly inhibit the growth and induce the apoptosis of MCF-7 cells. Western Blotting showed that isoflavone increased iNOS protein expression. These results suggested that isoflavone significantly inhibited the MCF-7 growth and induced cell apoptosis by regulating iNOS gene expression.
Fang
Qingwei
Q
Department of Public Health, Harbin Medical University, Harbin 150001, China.
Liu
Ying
Y
Song
Danfeng
D
Cui
Hongbin
H
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007529:Isoflavones; D019833:Genistein