Expression of mBRI2 in mice.
Mutations in the BRI(2) gene cause the autosomal dominant neurodegenerative diseases familial British dementia (FBD) and familial Danish dementia (FDD). BRI(2) is a member of a family of type 2 integral transmembrane spanning proteins, including mBRI(2), its murine homologue. The function of BRI(2) is unknown. Northern and Western analyses and in situ hybridization were employed to determine the expression of mBRI(2) in the mouse. mBRI(2) mRNA was expressed in several tissues including the liver, heart, lung, and ubiquitously throughout the brain. mBRI(2) protein was detected at high levels in many brain regions. Murine BRI(2) expression is similar to that described in the human brain but does not fully explain the distribution of pathology seen in FBD and FDD.
Pickford
Fiona
F
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, Florida, FL 32224, USA.
Onstead
Luisa
L
Camacho-Prihar
Carolina
C
Hardy
John
J
McGowan
Eileen
E
D048868:Adaptor Proteins, Signal Transducing; D000682:Amyloid / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015152:Blotting, Northern; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D051379:Mice; D009928:Organ Specificity; D012333:RNA, Messenger / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000682:Amyloid; C120083:ITM2B protein, human; C492300:Itm2b protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D012333:RNA, Messenger