A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase.
A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2'-hydroxy-4'-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.
Thomas
Michael G
MG
PanTherix Ltd., Todd Campus, West of Scotland Science Park, Glasgow G20 0XA, Scotland, UK. michael.thomas@panterix.co.uk
Lawson
Chris
C
Allanson
Nigel M
NM
Leslie
Bruce W
BW
Bottomley
Joanna R
JR
McBride
Andrew
A
Olusanya
Oyinkan A
OA
D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D003001:Cloning, Molecular; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019761:Phosphorus-Oxygen Lyases / Q000037:antagonists & inhibitors*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012765:Shikimic Acid / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D013329:Structure-Activity Relationship
D001572:Benzofurans; D001593:Benzyl Compounds; D004791:Enzyme Inhibitors; D012765:Shikimic Acid; C019895:chorismate synthase; D019761:Phosphorus-Oxygen Lyases