title: Effects of malathion plus superphosphate or urea on Najdi sheep.
abstract: The effects of p.o. administration of the combination of malathion + superphosphate or urea on Najdi sheep were evaluated in sheep dosed as untreated controls, malathion-treated at 25 mg/kg/d, superphosphate-treated at 450 mg/kg/d, urea-treated at 450 mg/kg/d, malathion-treated at 25 mg/kg/d + superphosphate treated at 450 mg/kg/d, or malathion treated at 25 mg/kg/d + urea treated at 450 mg/kg/d. Oral doses of malathion alone were lethal after 6 d, and malathion + urea were fatal after 6-8 d. Malathion + superphosphate caused death after 2-3 d. Malathion, but not superphosphate or urea, inhibited serum cholinesterase activity. Hepatonephropathy correlated with changes in serum AST, ALP, cholesterol, triglyceride, bilirubin, urea, total protein and albumin. Neither malathion nor its combination with superphosphate or urea caused peripheral neuropathy.
authors.affiliation: Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, PO Box 1482, Buraidah, Al-Qassim, Kingdom of Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Al-Qarawi
authors.forename: S E I
authors.initials: SE
authors.lastname: Adam
mesh_terms: D000284:Administration, Oral; D000818:Animals; D011756:Diphosphates / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005308:Fertilizers / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008294:Malathion / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D012756:Sheep; D014508:Urea / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D011756:Diphosphates; D005308:Fertilizers; D007306:Insecticides; C033414:superphosphate; D014508:Urea; D008294:Malathion