title: Multidrug resistance: can new drugs help chemotherapy score against cancer?
authors.forename: Bruce
authors.initials: B
authors.lastname: Goldman
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D017326:Clinical Trials, Phase III as Topic; D003524:Cyclosporins / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D015507:Drugs, Investigational / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000187:drug effects / Q000378:metabolism*; D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D014481:United States
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D003524:Cyclosporins; D003986:Dibenzocycloheptenes; D015507:Drugs, Investigational; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010880:Piperidines; D011725:Pyridines; D011804:Quinolines; C106077:biricodar; C095179:zosuquidar trihydrochloride; C070272:valspodar; C421109:multidrug resistance-associated protein 1