[Effect of xinhe granule on vascular endothelial damage and endothelial expressed endothelin and intercellular adhesion molecule-1 in rats fed with high lipid diet].
OBJECTIVE
To study the protective effect of Xinhe granule (XHG) on vascular endothelial damage in rats fed with high lipid diet.


METHODS
Model of vascular endothelial damage was formed by feeding high lipid diet in rats. The model animal were divided into high dosage XHG group, low dosage XHG group, composite Salvia dripping pellet group and model control group, and a blank (normal) control group was also set up. The degree of endothelial damage and positive cell count of synthesizing and secreting endothelin (ET-1) and intercellular adhesion molecule-1 (ICAM-1) were determined by endothelial cell spreading technique and immunohistochemical technique quantitatively.


RESULTS
Comparison of the degree on vascular endothelial damage and endothelial secreting ICAM-1 and ET-1 showed model control group > composite Salvia dripping pellet group > low dosage XHG group > high dosage XHG group > blank control group. XHG did not show obvious lowering action on blood lipid.


CONCLUSIONS
XHG could inhibit the endothelial expressed ICAM-1 and ET-1 in hyperlipidemia rats, thus displaying the protective effect on vascular endothelium.
Li
X
X
Affiliated Hospital of Shandong University of TCM, Jinan 250011.
Li
R F
RF
Ding
S W
SW
D000818:Animals; D002791:Cholesterol, Dietary / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D019332:Endothelin-1 / Q000032:analysis*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D008297:Male; D008517:Phytotherapy; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D002791:Cholesterol, Dietary; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D020011:Protective Agents; D018799:Intercellular Adhesion Molecule-1