title: Efficacy of three dose volumes of topically applied 65% permethrin against Ctenocephalides felis and Rhipicephalus sanguineus on dogs weighing 30 kg or more.
abstract: Twenty-five dogs were evenly and randomly allocated by weight to five treatment groups: untreated control, 2 ml 65% permethrin (dogs weighing 15 to 29 kg, "average dogs"), and 2, 3, or 4 ml 65% permethrin (dogs weighing > or = 30 kg, "big dogs"). Each dog was infested with 125 unfed, adult cat fleas, Ctenocephalides felis, and 50 unfed, adult brown dog ticks, Rhipicephalus sanguineus, on Days -3 (ticks only), -2 (fleas only), 3, 7, 14, 17, 21, 24, and 28. Fleas and ticks were counted 1 and 3 or 4 days after each infestation. The duration of efficacy (defined as >90%) against C. felis was 28 to 31 days. The efficacy against fleas 31 days after application of 2, 3, or 4 ml on big dogs ranged from 79.1% (2 ml) to 100% (4 ml). Big dogs that received either 3 or 4 ml of 65% permethrin had significantly (P < or = .05) fewer fleas at several evaluations between 15 and 31 days after treatment. The duration of efficacy against R. sanguineus was 15 (2 ml for big dogs) to 28 (2 ml for average dogs) days. The efficacy against R. sanguineus 28 days after treatment ranged from 79.1% (2 ml on big dogs) to 94.1% (2 ml on average dogs). Significantly (P < or = .05) fewer ticks were present at several evaluations after treatment on big dogs that received 3 or 4 ml than were present on big dogs treated with 2 ml. No significant differences were detected between the 3- and 4-ml groups from Days 10 to 31; however, the geometric mean number of ticks in the group treated with 4 ml was numerically lower than that for dogs treated with 3 ml on several occasions. These data indicate that a dose volume of 3 or 4 ml of 65% permethrin is needed to obtain an adequate level and duration of efficacy against both C. felis and R. sanguineus on dogs weighing 30 kg or more.
authors.affiliation: Schering Plough Animal Health, 1095 Morris Avenue, Union, NJ 07083, USA.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Endris
authors.forename: J Alexander
authors.initials: JA
authors.lastname: Hair
authors.forename: Terry L
authors.initials: TL
authors.lastname: Katz
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Zobre
authors.forename: Robert G
authors.initials: RG
authors.lastname: Pennington
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Meyer
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004283:Dog Diseases / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004478:Ectoparasitic Infestations / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D026023:Permethrin / Q000008:administration & dosage / Q000627:therapeutic use*; D005423:Siphonaptera; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary; D013987:Ticks; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D026023:Permethrin