[Clinical study on effect of sini decoction on ischemia/reperfusion injury by Holter monitoring in patients with acute myocardial infarction treated with thrombolytic therapy].
OBJECTIVE
To observe the clinical effect of Sini Decoction (SND) on ischemia/reperfusion injury in acute myocardial infarction (AMI).


METHODS
Randomized case-control clinical trial was conducted to observe the change of Holter monitoring in 22 cases of AMI treated with thrombolytic therapy before and after treatment.


RESULTS
The lasting time of acute ST segment, total burden of myocardial infarction, QRS score, QT dispersion and occurrence of reperfusion arrhythmia in patients received SND treatment were lower than those untreated with SND (P < 0.05).


CONCLUSIONS
SND is helpful in improving reperfusion injury of thrombolytic therapy in AMI patients.
Wu
W K
WK
Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510089.
Su
J W
JW
Lin
S G
SG
D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy; D015912:Thrombolytic Therapy / Q000009:adverse effects; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D014568:Urokinase-Type Plasminogen Activator