title: Disseminated infection due to Cylindrocarpon (Fusarium) lichenicola in a neutropenic patient with acute leukaemia: report of a case and review of the literature.
abstract: Described here is an unusual case of disseminated Cylindrocarpon lichenicola (Fusarium lichenicola) infection originating from a toenail lesion of a neutropenic woman with cellulitis of the foot and underlying acute leukaemia. A computed tomography scan of the chest showed multiple, ill-defined, nodular infiltrates with alveolar consolidation. The fungus was isolated from both the nail and the skin of the infected toe. Susceptibility testing revealed low minimum inhibitory concentrations for amphotericin B (0.78 micro g/ml) and voriconazole (1.56 micro g/ml) and high minimum inhibitory concentrations (>100 micro g/ml) for fluconazole, ketoconazole and itraconazole. The infection resolved after treatment with a total dose of 1 g of amphotericin B followed by oral itraconazole and bone marrow regeneration.
authors.affiliation: Department of Microbiology, Hôpital Erasme-ULB, route de Lennik 808, 1070 Brussels, Belgium. hrodrigu@ulb.ac.be
authors.forename: H
authors.initials: H
authors.lastname: Rodríguez-Villalobos
authors.forename: A
authors.initials: A
authors.lastname: Georgala
authors.forename: H
authors.initials: H
authors.lastname: Beguin
authors.forename: C
authors.initials: C
authors.lastname: Heymans
authors.forename: G
authors.initials: G
authors.lastname: Pye
authors.forename: F
authors.initials: F
authors.lastname: Crokaert
authors.forename: M
authors.initials: M
authors.lastname: Aoun
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002481:Cellulitis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016523:Foot Ulcer / Q000188:drug therapy / Q000382:microbiology*; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D009503:Neutropenia / Q000276:immunology*; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000276:immunology*; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents