Modulation of cellular signaling pathways: prospects for targeted therapy in hematological malignancies.
The high remission rates observed in patients with chronic myelogenous leukemia who receive Imatinib mesylate (Gleevec) indicate that targeted therapy for hematological malignancies is achievable. At the same time, progress in cellular biology over the past decade has resulted in a better understanding of the process of malignant transformation, a better classification of subtypes of each disease on the basis of molecular markers, and a better characterization of the molecular targets for drug development. These advances have already spawned the development of such effective agents as monoclonal antibodies and specific enzyme inhibitors. This review attempts to provide a practical introduction to the complex and growing field of targeted therapy in hematological malignancies.
Ravandi
Farhad
F
Department of Hematology/Oncology, The University of Illinois at Chicago, Chicago, Illinois 60612, USA. ravandi@uic.edu
Talpaz
Moshe
M
Estrov
Zeev
Z
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D002471:Cell Transformation, Neoplastic; D015195:Drug Design; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate