Primary plasmacytoma arising in an endocervical polyp with detection of neoplastic cells on papanicolaou test. A case report and review of the literature.
Primary plasmacytomas of the female genital tract are extremely rare and present a substantial diagnostic challenge. Five cases morphologically representing plasmacytomas and localized to the uterine cervix have been reported previously; however, only 1 was shown to be monotypic for immunoglobulin light-chain expression. We report the case of a 37-year-old woman who had highly atypical plasma cells on her Papanicolaou test. A clinically detected endocervical polyp was removed and revealed a plasmacytoma, the diagnosis of which was substantiated by demonstrating monotypic lambda-light-chain restriction and a clonal immunoglobulin heavy-chain gene rearrangement. The cytologic and histopathologic findings of plasmacytomas of the uterine cervix are discussed, including the utility of immunophenotypic and molecular techniques to confirm the neoplastic diagnosis.
Fischer
Edgar G
EG
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque 87131-5301, USA.
Bocklage
Thèrése J
TJ
Rabinowitz
Ian
I
Smith
Harriet O
HO
Viswanatha
David S
DS
D000328:Adult; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007150:Immunohistochemistry; D065006:Papanicolaou Test; D010954:Plasmacytoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011127:Polyps / Q000150:complications / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D014626:Vaginal Smears