Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats.
The effects of nicotine on the expressions of neuropeptide Y (NPY) and leptin receptor in the rat hypothalamus were investigated via immunohistochemistry. The results show that NPY expression is not affected in the arcuate nucleus (ARN) and is increased only slightly in the paraventricular nucleus (PVN) by nicotine administration under normal (i.e. fed) conditions and that leptin receptor expression is decreased slightly in the ARN and not affected in the PVN following nicotine treatment under the same conditions. Food deprivation enhanced NPY and suppressed leptin receptor expression in the ARN and PVN of the hypothalamus. Nicotine administration resulted in decreased NPY and increased leptin receptor levels.
Jang
Mi Hyeon
MH
Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemun-gu, 130-701, Seoul, South Korea.
Shin
Min Chul
MC
Kim
Khae Hawn
KH
Cho
Seong Yeon
SY
Bahn
Geon Ho
GH
Kim
Ee Hwa
EH
Kim
Chang Ju
CJ
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism; D005508:Food Deprivation; D005786:Gene Expression Regulation; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000378:metabolism*; D054411:Receptors, Leptin
D009478:Neuropeptide Y; D018722:Nicotinic Agonists; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D009538:Nicotine