title: [Changes in some parameters of nitric oxide synthesis in the early periods of development of hepatocarcinogenesis].
abstract: Our objective in this study was to determine some indices for the synthesis of nitric oxide in the early periods of diethylnitrosoamine-induced (10 mg/kg 5 times a week for two months) hepatocarcinogenesis in mature male rats (n = 100) and to gain insights into their relation to lipid peroxidation process. During the time-related course of hepatocarcinogenesis the blood serum level of L-arginin has been found to change significantly with time of the study while that of malonic dialdehyde tended to be on the increase. The SOD activity increased somewhat during the period of initiation, with its significant reduction recordable during the period of promotion and a striking increase in the initial period of progression. Unlike SOD, catalase was showing a tendency to increase after some decline in its activity.
authors.forename: Kh Ia
authors.initials: KhIa
authors.lastname: Karimov
authors.forename: F Kh
authors.initials: FKh
authors.lastname: Inoiatova
authors.forename: M T
authors.initials: MT
authors.lastname: Mukhamedova
mesh_terms: D000818:Animals; D001120:Arginine / Q000097:blood; D002374:Catalase / Q000378:metabolism; D004052:Diethylnitrosamine / Q000633:toxicity; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis*; D009585:Nitrogen Dioxide / Q000097:blood; D051381:Rats; D013997:Time Factors
chemical_list: D009569:Nitric Oxide; D004052:Diethylnitrosamine; D008315:Malondialdehyde; D001120:Arginine; D002374:Catalase; D009585:Nitrogen Dioxide