[Effect of xiaoyin jiedu yin on Staphylococcus aureus enterotoxin B induced serum interleukin 8 in mice].
OBJECTIVE
To explore the therapeutic mechanism of Xiaoyin Jiedu Yin (XYJDY) in treating psoriasis.


METHODS
Abnormal elevation of interleukin 8 (IL-8) level in mice was induced by Staphylococcus aureus enterotoxin B (SEB), then the antagonizing effects of XYJDY and Composite Qingdai Capsule were observed.


RESULTS
Serum IL-8 level arose and reached the peak 3-5 hrs after SEB induction. XYJDY could antagonize the induction significantly, and the effect was more significant when large dosage was given.


CONCLUSIONS
XYJDY, in either large or small dose, could effectively antagonize the SEB induction on IL-8. Applying with superantigen theory, this fact could be used to elucidate the mechanism of XYJDY in removing Heat, cooling blood and detoxifying at cell biologic level.
Liu
M
M
Beijing University of TCM, Beijing 100029.
Qu
X
X
Zhou
G F
GF
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004768:Enterotoxins / Q000037:antagonists & inhibitors*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy; D013211:Staphylococcus aureus
D004365:Drugs, Chinese Herbal; D004768:Enterotoxins; D016209:Interleukin-8; C031818:enterotoxin B, staphylococcal