[Effect of sanwu hypotensive decoction on blood pressure and lymphokine activated killer cell in patient of primary hypertension and spontaneously hypotensive rats].
OBJECTIVE
To investigate the effect of Sanwu hypotensive decoction (SWHD) on blood pressure (BP) and lymphokine activated killer cell (LAK) and possible mechanism.


METHODS
Thirty mild hypertension patients were treated with SWHD for 8 weeks, the levels of BP, proliferative ability and activity of LAK cell, SOD-like substance expressed by LAK cell and its radical scavenger ability before and after treatment were observed using randomized, single blinded, self-control, paralled assay, and compared with other 30 patients treated with captopril for control. In an experimental study, the vasodilatory response of thoracic aortic ring to acetylcholine and nitroglycerine, and effect of LAK cell, standard reagent of SOD, SWHD on the response were observed and compared in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKR).


RESULTS
After SWHD treatment, along with lowering of BP, the proliferative ability, activity SOD-like substance expressed by LAK cell and its radical scavenger ability increased significantly.


CONCLUSIONS
SWHD is not only an effective hypotensive agent, but also an immunoregulator.
Feng
P F
PF
Department of Cardiology, Affiliated Hospital of Zhejiang TCM College, Hangzhou 310006.
Liu
Y
Y
Qin
N P
NP
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000276:immunology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D016037:Single-Blind Method
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal