title: Analysis of genetic effects of major genes and polygenes on quantitative traits I. Genetic model for diploid plants and animals.
abstract: A genetic model was proposed to simultaneously investigate genetic effects of both polygenes and several single genes for quantitative traits of diploid plants and animals. Mixed linear model approaches were employed for statistical analysis. Based on two mating designs, a full diallel cross and a modified diallel cross including F(2), Monte Carlo simulations were conducted to evaluate the unbiasedness and efficiency of the estimation of generalized least squares (GLS) and ordinary least squares (OLS) for fixed effects and of minimum norm quadratic unbiased estimation (MINQUE) and Henderson III for variance components. Estimates of MINQUE (1) were unbiased and efficient in both reduced and full genetic models. Henderson III could have a large bias when used to analyze the full genetic model. Simulation results also showed that GLS and OLS were good methods to estimate fixed effects in the genetic models. Data on Drosophila melanogaster from Gilbert were used as a worked example to demonstrate the parameter estimation.
authors.affiliation: Department of Agronomy, Zhejiang University, Hangzhou, Zhejian 310029, PRC. jzhu@zju.edu.cn
authors.forename: X.-Y.
authors.initials: XY
authors.lastname: Lou
authors.forename: J.
authors.initials: J
authors.lastname: Zhu