title: Purification strategies for combinatorial and parallel chemistry.
abstract: This review surveys the methods developed for the purification of intermediates and final compounds originating from parallel and combinatorial chemistry. Included will be reviews of polymer-assisted purification, liquid-phase combinatorial chemistry, fluorous synthesis, liquid-liquid and solid-phase extraction, reverse-phase HPLC and supercritical fluid chromatography. A critique of each method is given, highlighting the methodologies strengths and weaknesses.
authors.affiliation: Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK. paul_edwards@sandwich.pfizer.com
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Edwards
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods; D002627:Chemistry, Physical / Q000295:instrumentation / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012680:Sensitivity and Specificity; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated; D011108:Polymers; D012997:Solvents