Neuronal network modelling of the effects of anaesthetic agents on somatosensory pathways.
The whole question of consciousness, awareness and depth of anaesthesia is both timely, little understood and deeply challenging. Models of the underlying neural pathway mechanisms/dynamics are necessary for understanding the interactions involved and their structure and function. A neuronal network of the somatosensory pathways is proposed in this paper based on experimental information and physiological investigation into anaesthesia. Existing mathematical neuronal models from the literature have been modified and then employed to describe the dynamics of the proposed pathway network. Effects of anaesthetic agents on the cortex were simulated in the model which describes the evoked cortical responses. By comparison with responses from anaesthetised rats, the model's responses are able to describe the dynamics of typical responses. Thus, the proposed model promises to be valuable for investigating the mechanisms of anaesthesia on the cortex and the effects of brain lesions.
Ting
C H
CH
Department of Biomechatronic Engineering, National Chiayi University, 300 University Road, Taiwan.
Angel
A
A
Linkens
D A
DA
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006801:Humans; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D000777:Anesthetics