title: [Study on the scavenging action of polysaccharide of Usnea longissima to oxygen radical and its anti-lipi peroxidation effects].
abstract: OBJECTIVE
  To study the scavenging action of polysaccharide of Usnea longissima Ach. (PUS) to oxygen free radical and its inhibiting action on lipidperoxidation.
  
  
  METHODS
  The scavenging action to superoxide anion free radical (O2-.) was tested by xanthine-xanthine oxidase system. The scavenging action on hydroxyl free racical (OH.) and anti-lipidperoxidation effects were tested by Fenton reaction.
  
  
  RESULTS
  The scaverging action was represented by the content scavenging 50% of all the free radical(IC50). The IC50 for O2-. and OH. were 0.45 mg/ml and 1.57 mg/ml respectively. The lipidperoxidation induced by OH. was weakly inhibited by PUS.
  
  
  CONCLUSIONS
  PUS can apparently scavenge oxygen free radical. But it can only weakly inhibit the lipid peroxidation of hepatocyte homogenate of mice which resulted form hydroxyl free radical.
authors.affiliation: College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Bian
authors.forename: Juqing
authors.initials: J
authors.lastname: Jin
authors.forename: Dongning
authors.initials: D
authors.lastname: Ding
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D051379:Mice; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020949:Usnea / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D011134:Polysaccharides; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical