Expression of co-stimulatory molecules on acute myeloid leukaemia blasts may effect duration of first remission.
Many solid tumours have been shown to lack expression of either of the immune co-stimulatory molecules CD80 (B7.1) or CD86 (B7.2), which is thought to be one of the ways in which tumours may escape immune recognition. We have examined the surface expression of CD80, CD86, human leucocyte antigen (HLA) class I and II, CD11a, CD54, and CD58 on the blast cells from patients with acute myeloid leukaemia (AML) at presentation. CD80 was only rarely expressed on AML blasts and, in those leukaemic cells expressing CD80, the level of expression was low. In contrast, expression of CD86 was detected on the AML blasts in more than half of the samples tested and, in some cases, the level of expression was equivalent to that of mature monocytes and activated B lymphocytes. The percentage of leukaemic blasts expressing CD86 was higher in the M4 and M5 French-American-British (FAB) types, and expression of CD11a and HLA class II was higher in the M4 FAB type. There was no difference in expression of CD80, CD54, CD58, or HLA Class I between different FAB subgroups. There was no significant difference in duration of first remission with expression of CD80, CD86, CD11a, CD54 or HLA class II. However, when expression of CD80 and CD86 were considered together, a significantly longer duration of remission was found. We suggest that these molecules may play a role in immunosurveillance, resulting in prolonged remission in some patients treated for AML.
Whiteway
Alastair
A
Department of Haematology, Royal Free & University College Medical School, London, UK.
Corbett
Tim
T
Anderson
Robert
R
Macdonald
Ian
I
Prentice
H Grant
HG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen; D018845:CD11 Antigens / Q000378:metabolism; D018968:CD58 Antigens / Q000378:metabolism; D002869:Chromosome Aberrations; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D012074:Remission Induction
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018845:CD11 Antigens; D018968:CD58 Antigens; C497964:CD86 protein, human; D006680:HLA Antigens; D008562:Membrane Glycoproteins; D018799:Intercellular Adhesion Molecule-1