Effect of chronic treatment with losartan on streptozotocin induced diabetic rats.
Treatment of rats with streptozotocin (STZ, 45mg/kg, i.v.,single dose) produced cardinal symptoms of diabetes mellitus including hyperglycemia, hypoinsulinemia and increase in blood pressure. Treatment with losartan--an angiotensin (AT1) receptor antagonist, 2 mg/kg, po for 6 weeks decreased the blood glucose levels by 16.5%. There was 190% increase in AUCglucose and 59.4% decrease in AUCinsulin in STZ-diabetic rats as compared to control rats. Treatment with losartan caused slight decrease in AUCglucose and slight increase in AUCinsulin. There was no significant difference in insulin sensitivity (K(ITT)) index of STZ-diabetic group as compared to control. Losartan treatment failed to alter these levels significantly. Serum cholesterol and creatinine levels were found to be increased significantly in STZ-diabetic rats. Treatment with losartan significantly prevented the rise in cholesterol and creatinine levels by 20.1 and 81% respectively. The results suggest that losartan produces some beneficial effects in STZ-diabetic rats.
Murali
B
B
Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, 380 009, India.
Goyal
R K
RK
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D019808:Losartan / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D001786:Blood Glucose; D007328:Insulin; D002784:Cholesterol; D003404:Creatinine; D019808:Losartan