title: Association of chromium exposure with multiple primary cancers in the nasal cavity.
abstract: A 56-year-old man who had worked at a chromate factory for 13 years developed squamous cell carcinoma of the left nasal cavity 11 years after retirement. He received intra-arterial chemotherapy, followed by surgery. Two years later, an adenocarcinoma was identified in the same nasal cavity just above the previous surgical region. He underwent medial maxillectomy in combination with postoperative irradiation. He has been disease free for 5 years after the second surgery. Microsatellite markers were examined in the second tumor specimen as a possible factor for carcinogenesis; however, replication errors were not observed in any of four loci (D2S123, D3S1067, TP53, D18S474) tested. The present case seems to have resulted from long-term exposure to chromium and, to our knowledge, is the first reported case with multiple primary cancers in the nasal cavity associated with chromium exposure.
authors.affiliation: Department of Otolaryngology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate 020-8505, Japan. hisato@iwate-med.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Murai
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kanda
authors.forename: Rokuro
authors.initials: R
authors.lastname: Mimura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hiratsuka
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000139:chemically induced* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000628:therapy; D002857:Chromium / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000628:therapy; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000628:therapy; D016273:Occupational Exposure / Q000009:adverse effects
chemical_list: D002857:Chromium