Genetic variability and transplantation.
OBJECTIVE
The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications.


RESULTS
Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation.


CONCLUSIONS
These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.
Marder
Brad
B
Mount Sinai School of Medicine, New York, USA.
Schröppel
Bernd
B
Murphy
Barbara
B
D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines