Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC.
Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.
Richart
Sarah M
SM
Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.
Simpson
Scott A
SA
Krummenacher
Claude
C
Whitbeck
J Charles
JC
Pizer
Lewis I
LI
Cohen
Gary H
GH
Eisenberg
Roselyn J
RJ
Wilcox
Christine L
CL
D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D000075983:Nectins; D009475:Neurons, Afferent / Q000821:virology*; D051381:Rats; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000378:metabolism; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism
D015815:Cell Adhesion Molecules; C000619010:NECTIN1 protein, human; C000619015:Nectin1 protein, mouse; D000075983:Nectins; D018124:Receptors, Tumor Necrosis Factor; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus; C506028:TNFRSF14 protein, human; C506029:Tnfrsf14 protein, mouse