Peroxisome proliferator-activated receptors (PPARs) in health and disease.
Peroxisome proliferator-activated receptors (PPARs) belong to the superfamily of steroid-thyroid-retinoid nuclear receptors. PPARs are transcription factors activated by specific ligands and play an important role during cell signalling. Intensive study of PPARs during recent years has revealed their importance in both normal physiology and in the pathology of various tissues. They participate in the regulation of lipid metabolism, inflammation and the development of atherosclerosis or diabetes. They also play a role in the regulation of growth and differentiation of cancer. It has been suggested that PPAR ligands may have potent anticancer effects and therefore may serve as potential anticancer drugs. In this review we focus on a role of PPARs in breast cancer and in glial tumors of the brain.
Ehrmann
Jirí
J
Department of Pathology, Laboratory of Molecular Pathology, Faculty of Medicine, Palacký University, Hnevotínská 3, Olomouc 77515, Czech Republic. erman@tunw.upol.cz
Vavrusová
Nicol
N
Collan
Yrjo
Y
Kolár
Zdenek
Z
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D001932:Brain Neoplasms / Q000503:physiopathology; D001943:Breast Neoplasms / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors