title: [The application of antisense technology in ophthalmology].
abstract: The research of gene regulation become more and more important with the advancement of the technology of molecular biology and gene study. Antisense molecules can regulate and modify gene expression. By using antisense technology, antisense RNA or artificial antisense oligonucleotides can be made to inhibit or block the transcription and translation of genes. These molecules are highly specific in gene regulation. The application of antisense technology in ophthalmology is introduced briefly in the review. This may be helpful to the studies in ophthalmic research field.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: J
authors.initials: J
authors.lastname: Ge
mesh_terms: D016373:DNA, Antisense / Q000494:pharmacology / Q000627:therapeutic use; D005128:Eye Diseases / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D005134:Eye Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D005901:Glaucoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D016376:Oligonucleotides, Antisense / Q000494:pharmacology / Q000627:therapeutic use*; D009885:Ophthalmology; D016372:RNA, Antisense / Q000494:pharmacology / Q000627:therapeutic use; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D016373:DNA, Antisense; D016376:Oligonucleotides, Antisense; D016372:RNA, Antisense; D012333:RNA, Messenger