title: The Bloom's syndrome helicase: keeping cancer at bay.
abstract: Bloom's syndrome, a very rare inherited disorder, predisposes its sufferers to the full range of cancers that afflict humanity. This predisposition is rooted in just one defective gene on chromosome 15. It encodes the BLM helicase - an enzyme that ordinarily protects against DNA damage arising during replication.
authors.affiliation: University of Oxford, UK.
authors.forename: Payam
authors.initials: P
authors.lastname: Mohaghegh
authors.forename: Ian D
authors.initials: ID
authors.lastname: Hickson
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics* / Q000378:metabolism; D001816:Bloom Syndrome / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15; D004265:DNA Helicases / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D053484:RecQ Helicases
chemical_list: D000251:Adenosine Triphosphatases; C097151:Bloom syndrome protein; D004265:DNA Helicases; D053484:RecQ Helicases