title: [Frequency of apolipoprotein E in a Nahua population].
abstract: The presence of different ethnic groups in Mexico may give rise to genetic diversity between the native Indian population and the Mestizos. It is therefore of medical and anthropological interest to analyze the genotypes of disease-associated loci, such as polymorphism in the apolipoprotein E gene, whose 4/4 allele increases the risk of Alzheimer's disease and coronary heart disease in other populations. We studied a Nahua Indian-population in the State of Morelos (Santo Domingo Ocotitlan). The ABO blood type of all individuals was determined and compared with the findings of other Nahua group from the State of Puebla. Without statistical significant differences in O, A and AB groups between both populations (p > 0.05). The allelic and genotypic frequency of apolipoprotein E was similar to that observed in other Mexican indian (Mazatecans, Mayans) and Mestizo populations, however there was a statistically significant difference when the results were compared to the allelic frequencies of other Amerinds: The Cayapa (Ecuador) for the epsilon 3 and epsilon 4 alleles (p < 0.002); the Nuuk (Greenland) for epsilon 3 and epsilon 4 alleles (p < 0.0001 and p < 0.002 respectively); and the Ammssalik (Greenland) for both alleles with p < 0.0001 and p = 0.04 respectively. In the case of the genotypes, there was statistically significant difference for the 4/3 genotypes, but a non significant difference for the 4/4 genotype. This is a descriptive study which contributes to the knowledge of the genetic structure of Mexican population.
authors.affiliation: Departamento de Consulta Externa, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez.
authors.forename: Roberto Alfonso
authors.initials: RA
authors.lastname: Suástegui Román
authors.forename: Petra
authors.initials: P
authors.lastname: Yescas Gómez
authors.forename: Jorge Luis
authors.initials: JL
authors.lastname: Guerrero Camacho
authors.forename: Adriana
authors.initials: A
authors.lastname: Ochoa Morales
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Aurelio
authors.initials: A
authors.lastname: Jara Prado
authors.forename: Oscar Alejandro
authors.initials: OA
authors.lastname: López-Caro
authors.forename: Ma Elisa
authors.initials: ME
authors.lastname: Alonso Vilatela
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D000483:Alleles; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D004484:Ecuador; D005006:Ethnicity / Q000235:genetics; D005838:Genotype; D006116:Greenland; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D004930:Inuit / Q000235:genetics; D008800:Mexico; D011110:Polymorphism, Genetic; D012204:Rh-Hr Blood-Group System / Q000235:genetics
chemical_list: D000017:ABO Blood-Group System; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D012204:Rh-Hr Blood-Group System