Midtrimester triple-test levels in women with chronic hypertension and altered renal function.
OBJECTIVE
To study the association between midtrimester triple-test levels and renal function in pregnant women with chronic hypertension.


METHODS
Forty-three patients with chronic hypertension for whom renal function was evaluated by the creatinine clearance test between 14- and 20-weeks gestation were studied. Midtrimester triple-test values obtained as part of Down screening program were correlated with renal function.


RESULTS
hCG correlated inversely with creatinine clearance (r = -0.345; p = 0.002) and directly with alpha-fetoprotein (r = 0.499; p = 0.003).


CONCLUSIONS
In pregnant women with chronic hypertension, impaired renal function may alter midtrimester maternal serum hCG levels.
Shenhav
Simon
S
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University of the Negev, Ashkelon 78306, Israel.
Gemer
Ofer
O
Sherman
Dan J
DJ
Peled
Ronit
R
Segal
Shmuel
S
D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D008423:Maternal Age; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000378:metabolism
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D003404:Creatinine