title: [Correlations between atopy and airway hyperresponsiveness].
abstract: To determine the correlations between atopy and airway hyperresponsiveness(AHR), 3000 nuclear families were selected by indicator case of asthma. All of questionaire, methacholine challenge test(5 g/L) and skin test(with 12 allergens) were conducted among all relatives in those nuclear families. The data were analysed through the EP15.01 and SAS6.12 and the odds ratio(OR) was obtained. The results of the skin prick tests on 12,516 relatives of the asthma nuclear families declared that the percentages of the positive erythema and rash were 12.5% and 51.3%, respectively. Furthermore, the positive rate of male was higher than that of female(P < 0.01). At the meantime, the positive rate under age of 35 was higher than that of people with the age over 35(P < 0.01). The prevalence of AHR was 11.9% among all relatives, in which the positive erythema and rash were 15.5% and 12.7%, respectively. Both the positive erythema and rash increased the risk of AHR, and their odds ratio are 1.17 and 1.14(P < 0.01), respectively, and the risk of AHR was greater with the increasing of kind of allergens causing the positive erythema or rash. The AHR was related with positive skin prick.
authors.affiliation: Biomedical Institute & School of Public Health, Anhui Medical University, Hefei 230032, China.
authors.forename: Yongtang
authors.initials: Y
authors.lastname: Jin
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Xu
authors.forename: Wenbing
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D016535:Bronchial Hyperreactivity / Q000150:complications* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D004890:Erythema / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012882:Skin Tests