title: Advancing drug discovery through systems biology.
abstract: Pharmaceutical companies are facing an urgent need to both increase their lead compound and clinical candidate portfolios and satisfy market demands for continued innovation and revenue growth. Here, we outline an emerging approach that attempts to facilitate and alleviate many of the current drug discovery issues and problems. This is, in part, achieved through the systematic integration of technologies, which results in a superior output of data and information, thereby enhancing our understanding of biological function, chemico-biological interactions and, ultimately, drug discovery. Systems biology is one new discipline that is positioned to significantly impact this process.
authors.affiliation: Beyond Genomics, 40 Bear Hill Road, Waltham, MA 02451, USA. edavidov@beyondgenomics.com
authors.forename: EugeneJ
authors.initials: E
authors.lastname: Davidov
authors.forename: JoanneM
authors.initials: J
authors.lastname: Holland
authors.forename: EdwardW
authors.initials: E
authors.lastname: Marple
authors.forename: Stephen
authors.initials: S
authors.lastname: Naylor
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods / Q000639:trends*; D020650:Combinatorial Chemistry Techniques; D019295:Computational Biology / Q000379:methods / Q000639:trends*; D015195:Drug Design; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D008660:Metabolism; D040901:Proteomics