[Synthesis of substituted 4-styrylcoumarin and their antitumor activities].
OBJECTIVE
A series of 4-styrylcoumarin derivatives had been designed and synthesized in order to find compounds of antitumor activities by screening.


METHODS
Title compounds (1-20) were synthesized by Phase-Transfer Wittig-Horner reaction, and screened by several antitumor models in vitro. Their structures were determined by 1HNMR, MS and elemental analysis.


RESULTS
Twenty compounds (1-20) are new compounds. Compound 18 had effects on KB cell lines in vitro.


CONCLUSIONS
It was seen that compound 18 had certain antitumor activities, and it was worth further studying.
Xu
S
S
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Xu
S P
SP
Li
L M
LM
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
C475448:7-acetoxy-4-styrylcoumarin; D000970:Antineoplastic Agents; D003374:Coumarins; D013343:Styrenes