title: [Effect of propylene glycol mannate sulfate on blood lipids and lipoprotein lipase in hyperlipidemic rat].
abstract: OBJECTIVE
  To study the effect of propylene glycol mannate sulfate (PGMS) on blood lipids and lipoprotein lipase in hyperlipidemic rat, and its anti-hyperlipidemic mechanism.
  
  
  METHODS
  PGMS was administered ig at different doses (37.8 mg.kg-1.d-1 and 75.6 mg.kg-1.d-1) to hyperlipidemic rats for three weeks and blood serum was obtained after starved 12 h. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were examined. The mRNA expression of lipoprotein lipase (LPL) in liver, spleen and artery was detected by reverse transcription polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  PGMS significantly decreased the levels of TC, TG and LDL-C and increased that of HDL-C in hyperlipidemic serum dose-dependently. PGMS was shown to increase the level of LPL mRNA expression, which is related directly to the controlling effects of PGMS on blood lipids.
  
  
  CONCLUSIONS
  PGMS modulated blood lipids by promoting mRNA expression of LPL. This may be one important mechanism of PGMS to modulate blood lipids.
authors.affiliation: Institute of Marine Drugs and Foods, Ocean University of Qingdao, Qingdao 266003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Wen-gong
authors.initials: WG
authors.lastname: Yu
authors.forename: Feng
authors.initials: F
authors.lastname: Han
authors.forename: Xin-zhi
authors.initials: XZ
authors.lastname: Lu
authors.forename: Qian-hong
authors.initials: QH
authors.lastname: Gong
authors.forename: Xiao-ke
authors.initials: XK
authors.lastname: Hu
authors.forename: Hua-shi
authors.initials: HS
authors.lastname: Guan
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D011409:Propylene Glycols / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000096:biosynthesis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D011409:Propylene Glycols; D012333:RNA, Messenger; D014280:Triglycerides; D008071:Lipoprotein Lipase