title: Lack of serological evidence for an association between simian virus 40 and lymphoma.
abstract: Recent studies have implicated simian virus 40 (SV40) in non-Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus-like-particle (VLP)-based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain.
authors.affiliation: Institut Catala d'Oncologia, Barcelona, Spain. desanjos@mail.nih.gov
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjose
authors.forename: Keerti V
authors.initials: KV
authors.lastname: Shah
authors.forename: Eva
authors.initials: E
authors.lastname: Domingo-Domenech
authors.forename: Eric A
authors.initials: EA
authors.lastname: Engels
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez de Sevilla
authors.forename: Tomas
authors.initials: T
authors.lastname: Alvaro
authors.forename: Mercedes
authors.initials: M
authors.lastname: Garcia-Villanueva
authors.forename: Vicens
authors.initials: V
authors.lastname: Romagosa
authors.forename: Eva
authors.initials: E
authors.lastname: Gonzalez-Barca
authors.forename: Raphael P
authors.initials: RP
authors.lastname: Viscidi
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000821:virology*; D016036:Seroepidemiologic Studies; D013539:Simian virus 40 / Q000276:immunology* / Q000302:isolation & purification*; D013030:Spain; D014771:Virion / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral