title: Evolutionary aspects of protein structure and folding.
abstract: The traditional reconstruction of molecular events of the past based on sequence conservation becomes very vague beyond one to two billion years ago. There are certain molecular features, however, such as polymer flexibility and loop closure, that are conserved merely because of their physical nature. This allows one to penetrate the earliest stages of protein evolution.
authors.affiliation: Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. trofonov@research.haifa.ac.il
authors.forename: Edward N
authors.initials: EN
authors.lastname: Trifonov
authors.forename: Igor N
authors.initials: IN
authors.lastname: Berezovsky
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*
chemical_list: D011506:Proteins