title: [Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors].
abstract: The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human alpha and B estrogen receptors was achieved.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, 5 rue Jean-Baptiste Clément, F92296-Chatenay Malabry Cedex.
authors.forename: S
authors.initials: S
authors.lastname: Kirkiacharian
authors.forename: A T
authors.initials: AT
authors.lastname: Lormier
authors.forename: M
authors.initials: M
authors.lastname: Resche-Rigon
authors.forename: F
authors.initials: F
authors.lastname: Bouchoux
authors.forename: E
authors.initials: E
authors.lastname: Cérède
mesh_terms: D002478:Cells, Cultured; D003374:Coumarins / Q000138:chemical synthesis* / Q000378:metabolism; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D006801:Humans; D007202:Indicators and Reagents; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D003374:Coumarins; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D007202:Indicators and Reagents; D011960:Receptors, Estrogen