title: Lethal 5-fluorouracil toxicity associated with a novel mutation in the dihydropyrimidine dehydrogenase gene.
authors.forename: A B P
authors.initials: AB
authors.lastname: van Kuilenburg
authors.forename: J W
authors.initials: JW
authors.lastname: Baars
authors.forename: R
authors.initials: R
authors.lastname: Meinsma
authors.forename: A H
authors.initials: AH
authors.lastname: van Gennip
mesh_terms: D000328:Adult; D000505:Alopecia / Q000139:chemically induced; D000740:Anemia / Q000139:chemically induced; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics*; D042943:Dihydrouracil Dehydrogenase (NADP); D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics* / Q000494:pharmacology*; D017354:Point Mutation; D013280:Stomatitis / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000964:Antimetabolites, Antineoplastic; D004273:DNA, Neoplasm; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil