Effect of ciprofloxacin on specific immune response in rabbits.
Ciprofloxacin (10 mg/kg body weight, iv, twice daily for 4 days) failed to alter specific antibody titres, total immunoglobulin concentration, total serum protein concentration, total leukocyte count, lymphocyte percentage, phagocytic index and skin thickness in DNCB skin sensitivity test against Brucella plain killed antigen in New Zealand White rabbits. It can be concluded that ciprofloxacin at the dose and duration employed did not adversely affect specific immune response in normal rabbits.
Jayakumar
K
K
Department of Pharmacology, Microbiology, Veterinary College, Hebbal, Bangalore 560 024, India. mail4jk@rediffmail.com
Honnegowda
Krishnappa
G
G
Sastry
K N V
KN
Narayana
K
K
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002004:Brucella Vaccine / Q000276:immunology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004137:Dinitrochlorobenzene / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D007107:Immune System / Q000187:drug effects*; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000276:immunology; D007273:Injections, Intramuscular; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D012882:Skin Tests
D000890:Anti-Infective Agents; D002004:Brucella Vaccine; D004137:Dinitrochlorobenzene; D007074:Immunoglobulin G; D002939:Ciprofloxacin