Novel 4-aminopyrimido[4,5-b]quinoline derivatives as potential antimicrobial agents.
Two series of 4-aminopyrimido[4,5-b]quinoline derivatives substituted in the 2-position 6a-c and/or in 1-position 9a-e have been prepared by facile routes starting from 2-amino-3-cyanoquinoline 2,2-chloro-3-cyanoquinoline 4 and 2-arylamino-3-cyanoquinolines 8a-d. The reactions involved simple fusion with thiourea or urea and, in some cases, with guanidine. The prepared compounds were in vitro tested for antimicrobial activities against some selected Gram-positive, Gram-negative bacteria and fungi. The products containing the thio-function were the most active followed by those containing the imino-function while the carbonyl containing derivatives were without significant antimicrobial effect.
el-Sayed
Ola A
OA
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, 21521, Egypt.
el-Bieh
Fatma M
FM
el-Aqeel
Shada I
SI
al-Bassam
Badr A
BA
Hussein
Maher E
ME
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D011804:Quinolines