title: Breast lesion characterization with contrast-enhanced US. Work in progress.
abstract: OBJECTIVE
  To characterise breast lesions on the basis of microcirculation features detected with contrast-enhanced US.
  
  
  METHODS
  Thirty-six patients aged 42-63 years (mean age 55 years) with a single breast lesion previously detected at standard mammography were studied. All US examinations were performed using an ATL HDI 5000 ultrasound device with a 5-10 MHz linear-array transducer, before and after administration of ultrasound contrast medium Levovist (Schering(R), Berlin) was administered by bolus injection (2 ml/s) via a 20 G catheter probe. The mechanical index was set to high to obtain instant rupture of the microbubbles under insonation. Intensity/time curves of the transient scattering in the region of interest (ROI) after contrast administration were extrapolated. The areas under the ROI curves were also evaluated to quantitatively assess the scattering.
  
  
  RESULTS
  The US baseline study and colour Doppler US identified 19 benign lesions (15 histologically proven) and 17 malignant lesions (16 histologically proven). The administration of contrast medium did not improve the specificity of the examination. Only by plotting the intensity/time curves of the regions of interest (ROI) and evaluating the areas under the ROI curves, was a significant correlation detected between US and histopathologic diagnosis.
  
  
  CONCLUSIONS
  Although further evaluation on a larger series is needed, the analysis of breast lesions by contrast-enhanced perfusion US seems to be a promising technique. Perfusion US can usefully complement high-frequency US, especially when mammography is inconclusive.
authors.affiliation: Dipartimento di Biotecnologie Mediche e Medicina Legale, Sezione di Scienze Radiologiche Pietro Cignolini, Università degli Studi di Palermo, Palermo, Italy. carusogi@libero.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caruso
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ienzi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cirino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salvaggio
authors.forename: Marcello
authors.initials: M
authors.lastname: Campione
authors.forename: Roberto
authors.initials: R
authors.lastname: Lagalla
authors.forename: Adelfio  Elio
authors.initials: A
authors.lastname: Cardinale
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D011134:Polysaccharides; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508