Effect of amitriptyline on gastric ulceration.
Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric-ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.
Sen
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T
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. sen@u469.montp.inserm.fr
Abdulsalam
C A
CA
Pal
S
S
Sen
S
S
Karmakar
S
S
Saravanan
K S
KS
Chaudhuri
A K Nag
AK
D000639:Amitriptyline / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects; D003080:Cold Temperature / Q000009:adverse effects; D000431:Ethanol / Q000009:adverse effects; D005744:Gastric Acid / Q000378:metabolism; D066298:In Vitro Techniques; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D008954:Models, Biological; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D018727:Muscarinic Antagonists; D000639:Amitriptyline; D000431:Ethanol; D001241:Aspirin; D007213:Indomethacin