title: Complete genomic sequences of astroviruses from sheep and turkey: comparison with related viruses.
abstract: The genomes of astroviruses infecting sheep and turkey were sequenced. Detailed analyses of these sequences were performed, including comparison with the other complete astrovirus sequences available as well as with other RNA virus sequences, with focus on the non-structural proteins and RNA sequences. Earlier postulated functional astrovirus RNA motifs and protein domains could in most cases be recognised in the sheep and turkey astrovirus sequences. In addition, analyses of the available astrovirus sequences revealed: two protein regions with the potential for forming coiled coils, differences in the postulated transmembrane region, a similarity between the putative astrovirus nuclear localisation signal and calicivirus genome-linked proteins, and a stretch of a highly conserved RNA sequence with a possible role in the astrovirus capsid gene expression. The present analyses contribute to the deciphering of pertinent functions of the astrovirus genomes.
authors.affiliation: Division of Infectious Disease Control, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-0403, Oslo, Norway.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Jonassen
authors.forename: Tom Ø
authors.initials: TØ
authors.lastname: Jonassen T
authors.forename: Torunn M
authors.initials: TM
authors.lastname: Sveen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Grinde
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019350:Astroviridae Infections / Q000662:veterinary* / Q000821:virology; D001483:Base Sequence; D016679:Genome, Viral; D001257:Mamastrovirus / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D011201:Poultry Diseases / Q000821:virology*; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D017422:Sequence Analysis, DNA; D012756:Sheep; D012757:Sheep Diseases / Q000821:virology*; D014421:Turkey; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D012367:RNA, Viral; D017361:Viral Nonstructural Proteins