title: Treatment of rubeosis iridis with photodynamic therapy with verteporfin--A new therapeutic and prophylactic option for patients with the risk of neovascular glaucoma?
abstract: Patients with ischaemic retinopathy who show iris neovascularization despite panretinal laser photocoagulation (PRP) very often develop a neovascular glaucoma. Photodynamic therapy (PDT) has been shown to occlude neovascularization without damage to physiologic vessels or adjacent tissue in the treatment of choroidal neovascularization (CNV) and might also be of value for patients with neovascular glaucoma who did not benefit from the PRP. First results of a monocentre, open label, intra-individual controlled, pilot phase I/II, dose-finding study demonstrate that PDT with verteporfin is capable of occluding neovascular vessels for a defined period of time without damaging adjacent tissue or physiologic iris vessels. Whether this vessel occlusion will have an impact on the progression of rubeosis or neovascular glaucoma will be the subject of further investigation.
authors.affiliation: Department of Ophthalmology, Charité Campus Virchow, Humboldt University, Berlin, Germany. valeska@mueller@hotmail.com
authors.forename: V A
authors.initials: VA
authors.lastname: Müller
authors.forename: P
authors.initials: P
authors.lastname: Ruokonen
authors.forename: M
authors.initials: M
authors.lastname: Schellenbeck
authors.forename: C
authors.initials: C
authors.lastname: Hartmann
authors.forename: M
authors.initials: M
authors.lastname: Tetz
mesh_terms: D015355:Glaucoma, Neovascular / Q000517:prevention & control*; D006801:Humans; D007498:Iris / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D010865:Pilot Projects; D011166:Porphyrins / Q000627:therapeutic use*; D012307:Risk Factors; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin