title: Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-kappaB p50 in hippocampal neurons after injury.
abstract: Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-kappaB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 9, Tampa, FL 33612, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Kassed
authors.forename: T L
authors.initials: TL
authors.lastname: Butler
authors.forename: M T
authors.initials: MT
authors.lastname: Navidomskis
authors.forename: M N
authors.initials: MN
authors.lastname: Gordon
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: K R
authors.initials: KR
authors.lastname: Pennypacker
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D006624:Hippocampus / Q000473:pathology*; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism*; D052002:NF-kappa B p50 Subunit; D009410:Nerve Degeneration / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D053764:Presenilin-1
chemical_list: D008565:Membrane Proteins; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; C508853:PSEN1 protein, human; D053764:Presenilin-1