title: GenePath: a system for automated construction of genetic networks from mutant data.
abstract: BACKGROUND
  Genetic networks are often used in the analysis of biological phenomena. In classical genetics, they are constructed manually from experimental data on mutants. The field lacks formalism to guide such analysis, and accounting for all the data becomes complicated when large amounts of data are considered.
  
  
  RESULTS
  We have developed GenePath, an intelligent assistant that automates the analysis of genetic data. GenePath employs expert-defined patterns to uncover gene relations from the data, and uses these relations as constraints in the search for a plausible genetic network. GenePath formalizes genetic data analysis, facilitates the consideration of all the available data in a consistent manner, and the examination of the large number of possible consequences of planned experiments. It also provides an explanation mechanism that traces every finding to the pertinent data.
  
  
  BACKGROUND
  GenePath can be accessed at http://genepath.org.
  
  
  BACKGROUND
  Supplementary material is available at http://genepath.org/bi-.supp.
authors.affiliation: University of Ljubljana, Faculty of Computer and Information Science Jozef Stefan Institute, Ljubljana, Slovenia.
authors.forename: Blaz
authors.initials: B
authors.lastname: Zupan
authors.forename: Janez
authors.initials: J
authors.lastname: Demsar
authors.forename: Ivan
authors.initials: I
authors.lastname: Bratko
authors.forename: Peter
authors.initials: P
authors.lastname: Juvan
authors.forename: John A
authors.initials: JA
authors.lastname: Halter
authors.forename: Adam
authors.initials: A
authors.lastname: Kuspa
authors.forename: Gad
authors.initials: G
authors.lastname: Shaulsky
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development; D004252:DNA Mutational Analysis / Q000379:methods*; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development; D005103:Expert Systems; D005786:Gene Expression Regulation / Q000502:physiology*; D007814:Larva / Q000235:genetics / Q000254:growth & development; D008957:Models, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D016037:Single-Blind Method; D012984:Software