How do transplanted olfactory ensheathing cells restore function?
In this article, we review our work on regeneration of the corticospinal tract in rats following a lesion at upper cervical level. We outline the rationale for using olfactory ensheathing cells, and summarize the evidence for regeneration and functional recovery. The present interpretation on the mechanisms of functional recovery is partly hypothetical, and we emphasize where further experimental evidence is needed.
Keyvan-Fouladi
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N
Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, MRC, The Ridgeway Mill Hill, London NW7 1AA, UK.
Li
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Y
Raisman
G
G
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology; D006801:Humans; D009412:Nerve Fibers / Q000637:transplantation; D009434:Neural Pathways / Q000166:cytology*; D018034:Olfactory Receptor Neurons / Q000502:physiology / Q000637:transplantation*; D011712:Pyramidal Tracts / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology; D013119:Spinal Cord Injuries / Q000628:therapy