title: Ethnic differences at risk for gestational trophoblastic disease in New Mexico: A 25-year population-based study.
abstract: OBJECTIVE
  The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data.
  
  
  METHODS
  All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor Registry and Vital Records and Health Statistics Annual Reports. Statistical methods included trends analyses, odds ratios, and Poisson regression.
  
  
  RESULTS
  Of 939 total cases, 312 non-Hispanic white women, 399 Hispanic white women, 201 American Indian women, and 27 other women were affected. Age-adjusted incidence rates were significantly higher for American Indian women (11.16%) compared with non-Hispanic (3.57%) or Hispanic white women (5.32%); the probability value was <.001. When live birth (1:438 women) and pregnancy (1:486 women) denominators were considered, American Indian women alone were at increased risk, and the ratio increased by 56% over 25 years. American Indian women were also at increased risk for partial mole (relative risk, 4.03; 95% CI, 2.57-6.31), invasive mole (relative risk, 26.7; 95% CI, 7.81-93.14), and choriocarcinoma (relative risk, 6.29; 95% CI, 1.81-22.66) variants.
  
  
  CONCLUSIONS
  American Indians are at increased risk relative to the other predominant ethnic groups in New Mexico. Age-adjusted standardization provided a reproducible measurement that may be applicable across other registries.
authors.affiliation: Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA. Hsmith@salud.unm.edu
authors.forename: Harriet O
authors.initials: HO
authors.lastname: Smith
authors.forename: Robert D
authors.initials: RD
authors.lastname: Hilgers
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Bedrick
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Qualls
authors.forename: Charles L
authors.initials: CL
authors.lastname: Wiggins
authors.forename: William F
authors.initials: WF
authors.lastname: Rayburn
authors.forename: Alan G
authors.initials: AG
authors.lastname: Waxman
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Stephens
authors.forename: Laurence W
authors.initials: LW
authors.lastname: Cole
authors.forename: Marian
authors.initials: M
authors.lastname: Swanson
authors.forename: Charles R
authors.initials: CR
authors.lastname: Key
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002822:Choriocarcinoma / Q000208:ethnology / Q000209:etiology; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000208:ethnology* / Q000209:etiology*; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D006828:Hydatidiform Mole / Q000208:ethnology / Q000209:etiology; D002820:Hydatidiform Mole, Invasive / Q000208:ethnology / Q000209:etiology; D007198:Indians, North American / Q000706:statistics & numerical data*; D009516:New Mexico / Q000453:epidemiology; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000208:ethnology / Q000209:etiology; D044465:White People / Q000706:statistics & numerical data*