Analysis of dietary supplements for arsenic, cadmium, mercury, and lead using inductively coupled plasma mass spectrometry.
The arsenic, cadmium, mercury, and lead contents of 95 dietary supplement products were determined using microwave digestion and high-resolution inductively coupled plasma mass spectrometry. Precision and accuracy were demonstrated by element recovery from 17 dietary supplements and replicates of 8 reference materials. The concentration ranges were as follows: arsenic, <5-3770 microg/kg; cadmium, <10-368 microg/kg; mercury, <80-16800 microg/kg; and lead, <20-48600 microg/kg. An assessment of estimated exposures/intakes of the four elements is presented.
Dolan
Scott P
SP
Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA.
Nortrup
David A
DA
Bolger
P Michael
PM
Capar
Stephen G
SG
D001151:Arsenic / Q000032:analysis*; D002104:Cadmium / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D007854:Lead / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D008452:Maximum Allowable Concentration; D008628:Mercury / Q000032:analysis*; D011786:Quality Control; D012680:Sensitivity and Specificity
D002104:Cadmium; D007854:Lead; D008628:Mercury; D001151:Arsenic