[Analytical methods used in pharmacokinetics studies for biotechnology drugs].
In order to provide a reference for selecting analytical methods in pharmacokinetics studies for biotechnology drugs such as recombinant proteins, monoclonal antibodies or genetic engineering antibodies and oligonucleotide drugs, the following methods such as radiolabels, immunoassays, bioassays, chromatography and even the novel protein-chip technique are reviewed. Their mechanisms, application fields, and advantages and limitations are also summarized.
Ju
Zhichang
Z
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Sun
Jinxiu
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009841:Oligonucleotides / Q000493:pharmacokinetics*; D011863:Radioimmunoassay; D016719:Radioimmunodetection; D011994:Recombinant Proteins / Q000493:pharmacokinetics*
D000911:Antibodies, Monoclonal; D009841:Oligonucleotides; D011994:Recombinant Proteins