title: Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.
abstract: OBJECTIVE
  To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
  
  
  METHODS
  Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
  
  
  RESULTS
  There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival.
  
  
  CONCLUSIONS
  The APOEepsilon4 allele in this population may be associated with poor survival following ICH.
authors.affiliation: Department of Neurology, Royal Victoria Hospital, Belfast, UK. mark.mccarron@royalhospitals.n-i.nhs.uk
authors.forename: M O
authors.initials: MO
authors.lastname: McCarron
authors.forename: C J
authors.initials: CJ
authors.lastname: Weir
authors.forename: K W
authors.initials: KW
authors.lastname: Muir
authors.forename: K L
authors.initials: KL
authors.lastname: Hoffmann
authors.forename: C
authors.initials: C
authors.lastname: Graffagnino
authors.forename: J A R
authors.initials: JA
authors.lastname: Nicoll
authors.forename: K R
authors.initials: KR
authors.lastname: Lees
authors.forename: M J
authors.initials: MJ
authors.lastname: Alberts
mesh_terms: D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000235:genetics* / Q000401:mortality*; D005260:Female; D005838:Genotype; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D044469:Racial Groups; D017678:Sex Distribution; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E