[Study on modulation effect of qi regulating and blood activating drugs on mechanism of immunity and hemorrheology in stressed rats].
OBJECTIVE
To explore the modulation effect of Chinese herbal medicines for Qi regulating and blood activating (QRBA) on mechanism of immunity and hemorrheology in stressed rats.


METHODS
The influence of QRBA on plasma noradrenaline (NA), proliferation of splenic cells and hemorrheologic properties were observed in stressed rats.


RESULTS
The Chinese herbal medicines for soothing Liver to regulate Qi, activating blood circulation to remove stasis and QRBA drugs could antagonize in various degrees the changes caused by stress. Among them QRBA drugs was the best, it could reduce the level of plasma NA (P < 0.01), modulate the blood hyperviscosity induced by exogenous NA (P < 0.05) and enhance proliferation of splenic cells (P < 0.01) in rats.


CONCLUSIONS
QRBA drugs strengthen immune function and restore hemorrheologic properties by reducing NA content in organism.
Qian
R Q
RQ
Department of Integration of Chinese and Western Medicine, School of Medicine, Peking University, Beijing 100083.
Yang
Y
Y
Jiang
W Y
WY
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018056:Hemorheology / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000276:immunology; D013312:Stress, Physiological / Q000097:blood / Q000276:immunology
D004365:Drugs, Chinese Herbal