Luteal phase support in ovarian induction cycles using human chorionic gonadotropin or oral progestagens.
OBJECTIVE
To determine the efficacy of luteal phase support with human chorionic gonadotropin (hCG) or oral progesterone during human menopausal gonadotropin (hMG) ovulation induction.


METHODS
Between September 1999 and March 2001, a total of 91 couples with infertility were recruited at Al-Hammadi Hospital, Riyadh, Kingdom of Saudi Arabia and Badeea Hospital, Jordan. In this prospective trial 46 couples were allocated to luteal phase support with hCG injections, while 45 couples were allocated to Duphaston (oral progestogens) as luteal support.


RESULTS
In the group of hCG luteal support, 46 patients completed 46 cycles of hMG therapy, and 8 pregnancies (5 ongoing pregnancies) ensued, with a general total pregnancy rate of 17.4%. In the progesterone (Duphaston) luteal support group, 45 patients with the similar indications to the previous group were studied and 8 pregnancies (5 ongoing pregnancies) were reported with a general total pregnancy rate of 17.8%. Only one spontaneous abortion occurred among the patients in a cycle supported with supplemental hCG, while 2 abortions occurred in the Duphaston supported group.


CONCLUSIONS
Despite theoretical reasons to use luteal phase support during hMG-stimulated cycles, our data showed no improvement in pregnancy rates from such treatment.
Zayed
Faheem F
FF
Department of Obstetrics and Gynecology, Jordan University of Science and Technology, PO Box 962106, Amman 11196, Jordan, Kingdom of Saudi Arabia. fhmzayed@just.edu.jo
El-Jallad
Mohammad F
MF
Al-Chalabi
Haifa A
HA
D000284:Administration, Oral; D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004394:Dydrogesterone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007273:Injections, Intramuscular; D008183:Luteal Phase; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D004394:Dydrogesterone