title: BMRI in early detection of breast cancer in patients with increased genetic risk: our preliminary results.
abstract: Because of the higher risk of developing breast cancer and the early onset of the disease in women proved or suspected to be carriers of a breast cancer susceptibility gene, a dedicated screening should be offered as a less invasive approach with respect to the otherwise suggested prophylactic mastectomy. This should be optimized in order to overcome the limitations of conventional breast imaging with the application of new technologies such as Breast Magnetic Resonance Imaging (BMRI). A diagnostic protocol for routine control in patients with high risk for developing breast cancer has been prepared. Within a 7 months period, 23 patients suspected or proved to carry a breast cancer susceptibility gene underwent BMRI. Four breast cancers were identified with BMRI. In these cases mammography was negative because of the density of the parenchyma or for its fibroglandular pattern. US was negative in two cases, not specific for malignancy in one case and considered as only possibly malignant but with biopsy recommendation on the basis of MR findings in the last one. Clinic analysis was positive for mass in two cases. The accuracy of BMRI is known to be higher than that of conventional imaging in the study of breast parenchyma. High spatial resolution and no breast density influence can give more detailed information about smaller lesions and the right extent of the disease.
authors.affiliation: Unit of Diagnostic Radiology A, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Trecate
authors.forename: D
authors.initials: D
authors.lastname: Vergnaghi
authors.forename: S
authors.initials: S
authors.lastname: Bergonzi
authors.forename: T
authors.initials: T
authors.lastname: De Simone
authors.forename: C
authors.initials: C
authors.lastname: Costa
authors.forename: G B
authors.initials: GB
authors.lastname: Spatti
authors.forename: B
authors.initials: B
authors.lastname: Pasini
authors.forename: R
authors.initials: R
authors.lastname: Musumeci
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D009154:Mutation; D013382:Subtraction Technique; D016217:Ultrasonography, Mammary