title: [LC-MS analysis of related substances in ampicillin and amoxicillin].
abstract: OBJECTIVE
  To analyze the related substances in ampicillin and amoxicillin and determine the related substances in products.
  
  
  METHODS
  By using HPLC, electrospray ionzation and selective ion monitoring mass spectrum method, accelerated samples were analyzed for determination the related substances in ampicillin and amoxicillin.
  
  
  RESULTS
  Thirteen related substances in ampicillin and 9 related substances in amoxicillin were determined.
  
  
  CONCLUSIONS
  The results are useful to quality control and stability study for ampicillin and amoxicillin.
authors.affiliation: Research and Development Drug Center, North China Pharmaceutical Corporation, Shijiazhuang 050015, China. niuchangqun@yeal.net
authors.forename: C Q
authors.initials: CQ
authors.lastname: Niu
authors.forename: S Q
authors.initials: SQ
authors.lastname: Zhu
mesh_terms: D000658:Amoxicillin / Q000032:analysis* / Q000737:chemistry; D000667:Ampicillin / Q000032:analysis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D011786:Quality Control; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D000658:Amoxicillin