Coordination of the random asynchronous replication of autosomal loci.
Random monoallelic expression and asynchronous replication define an unusual class of autosomal mammalian genes. We show that every cell has randomly chosen either the maternal or paternal copy of each given autosome pair, such that alleles of these genes scattered across the chosen chromosome replicate earlier than the alleles on the homologous chromosome. Thus, chromosome-pair non-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of mouse chromosomes.
Singh
Nandita
N
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
Ebrahimi
Farah A W
FA
Gimelbrant
Alexander A
AA
Ensminger
Alexander W
AW
Tackett
Michael R
MR
Qi
Peimin
P
Gribnau
Joost
J
Chess
Andrew
A
D000483:Alleles; D000818:Animals; D002875:Chromosomes / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D005260:Female; D015870:Gene Expression; D018392:Genomic Imprinting; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D018035:Receptors, Odorant / Q000235:genetics; D013997:Time Factors
D018035:Receptors, Odorant