title: Clinical study of diclofenac sodium eyedrops used before and after cataract operation.
abstract: OBJECTIVE
  To determine the effect of 0.1% diclofenac sodium (DS) eyedrops made in China on preventing surgically induced miosis and inflammation.
  
  
  METHODS
  Seventy cases of cataract inpatients were randomly divided into two groups. DS eyedrops and normal saline as placebo were applied respectively 3 h, 1 h, 0.5 h before operation and once every morning for 7 days after operation. The pupil diameter was measured five times at different stages during the extracapsular cataract extraction. The eyepain, photophobia, conjunctival injection, KP, aqueous flare and light reaction of pupil were observed once a day after operation for a week.
  
  
  RESULTS
  37 eyes in DS group and 33 eyes in placebo group were included in the study. 32 of 37 eyes in DS group (86.5%) maintained mydriasis in all stages of operation and 33 eyes (89.2%) did not show any obvious sign of inflammation. There was statistically significant difference between the two groups. No serious side effects occurred in the DS group.
  
  
  CONCLUSIONS
  The DS eyedrops can prevent surgically induced miosis. Its antiinflammatory effect was significantly better than that of placebo drops.
authors.affiliation: Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan 430022, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Wei
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002387:Cataract Extraction / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D015877:Miosis / Q000517:prevention & control*; D009883:Ophthalmic Solutions
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac