title: Endogenous nitric oxide production in the airways of preterm and term infants.
abstract: Few studies have measured endogenous nitric oxide exhaled from the respiratory system of newborn infants. We measured exhaled nitric oxide (eNO) in the first 48 h of life in 24 (13 preterm, 11 term) spontaneously breathing (online method) newborns using a chemoluminescence analyzer. There was a significant difference in the eNO concentration between term and preterm healthy infants in the first 2 days of life (repeated measures analysis of variance, p < 0.05). In term infants there is a peak eNO production in the first hours of life, suggesting a potential role in postnatal adaptation, while in preterm infants eNO production is almost absent at birth, and then gradually increases.
authors.affiliation: Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy.
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Colnaghi
authors.forename: Valentina
authors.initials: V
authors.lastname: Condò
authors.forename: Lorenza
authors.initials: L
authors.lastname: Pugni
authors.forename: Monica
authors.initials: M
authors.lastname: Fumagalli
authors.forename: Fabio
authors.initials: F
authors.lastname: Mosca
mesh_terms: D000704:Analysis of Variance; D001944:Breath Tests; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009296:Nasal Cavity; D009569:Nitric Oxide / Q000096:biosynthesis*; D009994:Osmolar Concentration; D012119:Respiration; D012137:Respiratory System / Q000378:metabolism*; D013997:Time Factors
chemical_list: D009569:Nitric Oxide