Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex.
Ernst
Justin T
JT
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA.
Becerril
Jorge
J
Park
Hyung Soon
HS
Yin
Hang
H
Hamilton
Andrew D
AD
D040761:Biomimetic Materials / Q000737:chemistry*; D019281:Dimerization; D005021:Ethylamines / Q000737:chemistry*; D005454:Fluorescence Polarization; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein
C474007:Bax protein (53-86); D005021:Ethylamines; D008565:Membrane Proteins; D010446:Peptide Fragments; D010455:Peptides; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein; C019529:polyalanine; C027070:N,N-diisopropylethylamine