title: [Synthesis and activities of 4-deoxy-4 beta-arylmehtylene sulfonylamido-4'-demethylpodophyllotoxins].
abstract: OBJECTIVE
  To find new anticancer drug based on the structure of podophyllotoxin.
  
  
  RESULTS
  4-Deoxy-4-beta-arylmethylenesulfonylamido-4'- demethylpodophyllotoxins were (1-15) synthesized and their antitumour activities against KB cells and L1210 leukemia cells were tested.
  
  
  CONCLUSIONS
  These compounds are new compounds. Among them, compounds 2, 3, 8, 9, 11 and 12 showed antitumour activities. When halides exist on the aryl ring of substituted sulfonyl group, the corresponding compound has relatively higher activities. The stereo factor is important for the activities.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China. weiyma@onlie.sh.cn
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: W Y
authors.initials: WY
authors.lastname: Ma
authors.forename: X H
authors.initials: XH
authors.lastname: Chen
authors.forename: C N
authors.initials: CN
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007939:Leukemia L1210 / Q000473:pathology; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011034:Podophyllotoxin