Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer.
We measured and compared the levels of plasma monocyte-derived microparticles (MDMP) and platelet activation markers [plasma platelet-derived microparticles (PDMP), CD62P binding to platelets; plt-CD62P, CD63 binding to platelets; plt-CD63], to develop a better understanding of their potential contribution to vascular complications of lung cancer. The concentrations of MDMP and PDMP in lung cancer patients were significantly higher (P < 0.01) than those in normal subjects. Levels of plt-CD62P and plt-CD63 were significantly higher (P < 0.001 for each) in lung cancer patients than in controls. Levels of sE-selectin were also higher in lung cancer patients than in control subjects. MDMP correlated positively with plt-CD62P, plt-CD63, and PDMP with its relation to PDMP being particularly significant. The number of MDMPs and PDMPs are patients who are non-small cell lung cancer were significantly higher than that in small cell lung cancer patients. In addition, levels of sE-selectin were higher in non-small cell lung cancer than in small cell lung cancer patients. These findings suggest that elevated MDMPs may be a sign of vascular complication in lung cancer patients, particularly those who suffer from non-small cell lung cancer.
Kanazawa
Shigenori
S
The First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8507, Japan.
Nomura
Shosaku
S
Kuwana
Midori
M
Muramatsu
Mikiko
M
Yamaguchi
Kazuyuki
K
Fukuhara
Shirou
S
D017304:Annexin A5 / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D001792:Blood Platelets / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology; D019040:E-Selectin / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D015539:Platelet Activation / Q000502:physiology*
D017304:Annexin A5; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D019040:E-Selectin