title: Model-based imaging of cardiac electrical excitation in humans.
abstract: Activation time (AT) imaging from electrocardiographic (ECG) mapping data has been developing for several years. By coupling ECG mapping and three-dimensional (3-D) + time anatomical data, the electrical excitation sequence can be imaged completely noninvasively in the human heart. In this paper, a bidomain theory-based surface heart model AT imaging approach was applied to single-beat data of atrial and ventricular depolarization in two patients with structurally normal hearts. In both patients, the AT map was reconstructed from sinus and paced rhythm data. Pacing sites were the apex of the right ventricle and the coronary sinus (CS) ostium. For CS pacing, the reconstructed AT pattern on the endocardium of the right atrium was compared with the CARTO map in both patients. The localization errors of the origins of the initial endocardial breakthroughs were determined to be 6 and 12 mm. The sites of early activation and the areas with late activation were estimated with sufficient accuracy. The reconstructed sinus rhythm sequence was in good qualitative agreement with the pattern previously published for the isolated Langendorff-perfused human heart.
authors.affiliation: Institute of Biomedical Engineering, Graz University of Technology. bernhard.tilg@umit.at
authors.forename: Bernhard
authors.initials: B
authors.lastname: Tilg
authors.forename: Gerald
authors.initials: G
authors.lastname: Fischer
authors.forename: Robert
authors.initials: R
authors.lastname: Modre
authors.forename: Friedrich
authors.initials: F
authors.lastname: Hanser
authors.forename: Bernd
authors.initials: B
authors.lastname: Messnarz
authors.forename: Michael
authors.initials: M
authors.lastname: Schocke
authors.forename: Christian
authors.initials: C
authors.lastname: Kremser
authors.forename: Thomas
authors.initials: T
authors.lastname: Berger
authors.forename: Florian
authors.initials: F
authors.lastname: Hintringer
authors.forename: Franz Xaver
authors.initials: FX
authors.lastname: Roithinger
mesh_terms: D000328:Adult; D000368:Aged; D001282:Atrial Flutter / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006325:Heart Atria; D006352:Heart Ventricles; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D014927:Wolff-Parkinson-White Syndrome / Q000503:physiopathology