Molecular strategies to study Plasmodium-mosquito interactions.
It is widely known that malaria kills millions of people every year. Less well recognized is the fact that the situation is steadily deteriorating for a lack of effective means to counter the disease. An essential first step towards the development of new approaches to fight malaria is a thorough understanding of the mechanisms that direct parasite growth and differentiation, including parasite-host interactions. This article reviews recent achievements and introduces some promising new technologies and approaches for studying host-parasite interactions.
Ghosh
Anil
A
Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Cleveland, Ohio 44106-4955, USA.
Srinivasan
Prakash
P
Abraham
Eappen G
EG
Fujioka
Hisashi
H
Jacobs-Lorena
Marcelo
M
D000818:Animals; D009033:Culicidae / Q000235:genetics / Q000469:parasitology* / Q000502:physiology; D005786:Gene Expression Regulation; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors / Q000235:genetics / Q000469:parasitology* / Q000502:physiology; D008018:Life Cycle Stages; D008288:Malaria / Q000469:parasitology / Q000635:transmission; D020411:Oligonucleotide Array Sequence Analysis; D010961:Plasmodium / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D040901:Proteomics