title: Antiphospholipid antibodies and stroke in Down syndrome.
abstract: Two patients with Down syndrome and the primary antiphospholipid antibody are described. One patient had a vasculopathy similar to that previously described as Moyamoya. Down syndrome is characterized by immune defects including a tendency to autoimmune phenomena. This report extends the scope of these observations and particularly draws out the potential role of antiphospholipid antibodies. Indeed antiphospholipid antibodies may well explain the well-known association of Down syndrome and stroke.
authors.affiliation: Department of Immunopathology, The Canberra Hospital and the Canberra Clinical School, University of Sydney, Garran, ACT, Australia. paul.gatenby@act.gov.au
authors.forename: P
authors.initials: P
authors.lastname: Gatenby
authors.forename: R
authors.initials: R
authors.lastname: Tucko
authors.forename: C
authors.initials: C
authors.lastname: Andrews
authors.forename: R
authors.initials: R
authors.lastname: O'Neil
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D004314:Down Syndrome / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D020521:Stroke / Q000150:complications* / Q000276:immunology*
chemical_list: D017152:Antibodies, Antiphospholipid