Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented guinea pig.
Twelve male pigmented guinea pigs underwent either a unilateral vestibular deafferentation (UVD) (n=6) or sham operation (n=6). Compared to the pre-operated salivary cortisol concentrations, the UVD operation resulted in a significant increase in night cortisol concentrations (P<0.05) and a significant interaction between the night cortisol concentration and time (P<0.05). There was no significant difference between the pre- and post-UVD morning salivary cortisol concentrations; nor between the pre- and post-sham morning or night salivary cortisol concentrations. This study suggests that the ocular-motor and postural syndrome is causing the activation of the hypothalamic-pituitary-adrenal (HPA) axis.
Gliddon
Catherine M
CM
Vestibular Research Group, Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, PO Box 913, Dunedin, New Zealand.
Darlington
Cynthia L
CL
Smith
Paul F
PF
D000818:Animals; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007118:Immunoassay; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011897:Random Allocation; D012463:Saliva / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000502:physiology* / Q000503:physiopathology
D006854:Hydrocortisone