Monitoring low molecular weight heparins.
Low molecular weight heparin (LMWH) is used in the treatment of various thrombotic disorders. The clinical indications, pharmacology, and complications of therapy are reviewed. The indications for the need for monitoring include renal failure, obesity, pregnancy, and pediatric use. Monitoring focuses on the anti-Xa properties of LMWH. The two major assay types, chronometric (clotting) and chromogenic (amidolytic), are reviewed and compared.
Garon
Jack E
JE
Chicago Medical School, Mt. Sinai Hospital, Chicago, Illinois, USA.
D000925:Anticoagulants / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D001774:Blood Chemical Analysis / Q000379:methods; D016903:Drug Monitoring; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D014481:United States; D020246:Venous Thrombosis / Q000188:drug therapy
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight