title: Evaluation of anti-pyretic potential of Ficus racemosa bark.
abstract: A study was carried out to evaluate the anti-pyretic effect of a methanol extract of stem bark of Ficus racemosa Linn. (MEFR) on normal body temperature and yeast-induced pyrexia in albino rats. A yeast suspension (10 ml/kg body wt.) increased rectal temperature 19 h after subcutaneous injection. The MEFR, at doses of 100, 200 and 300 mg/kg body wt. p.o., showed significant dose-dependent reduction in normal body temperature and yeast-provoked elevated temperature. The effect extended up to 5 h after drug administration. The anti-pyretic effect of MEFR was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: R Bhaskara
authors.initials: RB
authors.lastname: Rao
authors.forename: K
authors.initials: K
authors.lastname: Anupama
authors.forename: K R L Anand
authors.initials: KR
authors.lastname: Swaroop
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000517:prevention & control*; D030681:Ficus; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D051381:Rats; D015003:Yeasts
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen