[Effects of pressure induced retinal ischemia on ERG in rabbit].
OBJECTIVE
To observe the effects of pressure induced retinal ischemia on electroretinogram(ERG) in rabbit.


METHODS
Retinal ischemia was induced in rabbits by increasing intraocular pressure at 30 mmHg, 60 mmHg, 90 mmHg, 120 mmHg for 45 minutes, and retinal function was monitored by eletroretinography.


RESULTS
There was no difference on ERG before or after the experiment both in 30 mmHg group and control one. In 60 mmHg pressure induced ischemia eyes, the amplitudes of the b-wave and OPs wave reduced significantly. Four hours after reperfusion, they were totally recovered. After an ischemic insult of 90 mmHg or 120 mmHg for 45 minutes, there was no response of ERG. Four hours later, the amplitudes of the b-wave and OPs wave were 66.912 +/- 20.157 and 16.423 +/- 3.965 the former, 38.852 +/- 23.438 and 8.610 +/- 12.090 the latter, respectively.


CONCLUSIONS
These results suggest that higher intraocular pressure causes more severe retina ischemic damage, and less recovery ability.
Song
G
G
Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China.
Yang
X
X
Zhang
Z
Z
Zhang
D
D
D000818:Animals; D004596:Electroretinography; D005260:Female; D007429:Intraocular Pressure; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009798:Ocular Hypertension / Q000150:complications / Q000503:physiopathology*; D011817:Rabbits; D011897:Random Allocation; D012171:Retinal Vessels / Q000503:physiopathology