title: S-domain assembly of the signal recognition particle.
abstract: The signal recognition particle (SRP) is a phylogenetically conserved ribonucleoprotein that associates with ribosomes to mediate the targeting of membrane and secretory proteins to biological membranes. In higher eukaryotes, SRP biogenesis involves the sequential binding of SRP19 and SRP54 proteins to the S domain of 7S RNA. The recently determined crystal structures of SRP19 in complex with the S domain, and that of the ternary complex of SRP19, the S domain and the M domain of SRP54, provide insight into the molecular basis of S-domain assembly and SRP function.
authors.affiliation: Umeå Centre for Molecular Pathogenesis, Umeå University, SE-901 87 Umeå, Sweden. liz@ucmp.umu.se
authors.forename: A Elisabeth
authors.initials: AE
authors.lastname: Sauer-Eriksson
authors.forename: Tobias
authors.initials: T
authors.lastname: Hainzl
mesh_terms: D001665:Binding Sites; D003461:Crystallography / Q000379:methods; D004926:Escherichia coli / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D020733:RNA, Small Cytoplasmic / Q000737:chemistry / Q000378:metabolism; D018271:Signal Recognition Particle / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: C115990:7SL RNA; D046911:Macromolecular Substances; D020733:RNA, Small Cytoplasmic; C117074:SRP19 protein, human; D018271:Signal Recognition Particle