title: [Study on sense neurotrophism of denervated red and white muscles].
abstract: OBJECTIVE
  To clarify the character of nerve growth factor (NGF) in the denervated red and white muscles and the relationship between the amount of NGF and sensitive neurotrophism of denervated red and white muscles.
  
  
  METHODS
  The model of the denervated gastrocnemius and soleus was made by clipping the sciatic nerve of Wister rats. The immunohistochemistry was taken to measure the amount of NGF in muscles, and the neurotrophism of extracts of muscles was tested with culture of dorsal root ganglions at the 1st, 3rd, 7th and 14th days after injury.
  
  
  RESULTS
  The amount of NGF in denervated gastrocnemius and soleus decreased, especially in soleus. The neruotrophism of the extracts of the two kinds of denervated muscles did not decrease; on the contrary, it increased after a week after injury.
  
  
  CONCLUSIONS
  The injury of peripheral nerves causes the amount of NGF in the target tissues to increase, but the change is different between the denervated muscles; the neurotrophism of the extracts of musclesis determined by all kinds of neurotrophic factors, and can not be explained by a single factor.
authors.affiliation: Emergency and Trauma Department, Tianjin Orthopedics Hospital, Tianjin, P. R. China 300211.
authors.forename: Jing-bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Yong-xiang
authors.initials: YX
authors.lastname: Luo
authors.forename: Wen-ge
authors.initials: WG
authors.lastname: Liu
mesh_terms: D000818:Animals; D046508:Culture Techniques; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation* / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries*
chemical_list: D009414:Nerve Growth Factors