Reduced expression of heterogeneous nuclear ribonucleoprotein B1 in adult T-cell lymphoma/leukemia.
It is considered that hnRNP B1 expresses similarly in the various types of tumor cells. Recently, we demonstrated high B1 expression in B-cell lymphoma and carcinoma. To evaluate the difference of B1 expression between B and T-cell lymphoma, we immunologically studied the B1 expression in 22 cases with nodal T-cell lymphoma, comprising adult T-cell leukemia/lymphoma (ATLL; n=15) and angioimmunoblastic T-cell lymphoma (AILD; n=7), using an anti-hnRNP B1 monoclonal antibody, 2B2. In ATLL cases, scattered large transformed lymphoma cells demonstrated strong B1 expression, while the medium-sized lymphoma cells were negative. On the one hand, lymphoma cells in AILD diffusely expressed B1. The mean B1 expression rate in ATLL was 22%, which was significantly lower than that in AILDs (45%), B-cell lymphomas (44%), and metastatic carcinomas (53%) (p<0.01). Our result might suggest that process of hnRNP B1 expression in ATLL differs from those in other lymphoid neoplasms and carcinoma.
Tani
Hiroki
H
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.
Ohshima
Koichi
K
Haraoka
Seiji
S
Hamasaki
Makoto
M
Kamma
Hiroshi
H
Ikeda
Seiyo
S
Kikuchi
Masahiro
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D045744:Cell Line, Tumor / Q000737:chemistry; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000473:pathology
D000911:Antibodies, Monoclonal; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D009363:Neoplasm Proteins; C439768:hnRNP A2