title: Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-alpha in a patient with chronic myelogenous leukemia.
abstract: We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-alpha (IFN-alpha) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-alpha treatment.
authors.affiliation: First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kato
authors.forename: Toshiya
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Saito
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D016898:Interferon-alpha / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D010677:Philadelphia Chromosome
chemical_list: D007166:Immunosuppressive Agents; D016898:Interferon-alpha; D016179:Granulocyte Colony-Stimulating Factor