[Study on water of crystallization in tazobactam].
OBJECTIVE
To investigate whether tazobctam has crystallization water.


METHODS
In order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied.


RESULTS
The water content of the same batch tazobactam determined by different mthods was different.


CONCLUSIONS
The results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.
Yuan
Yao-zuo
YZ
Jiangsu Province Institute of Drug Control, Nanjing 210008, China.
Hu
Chang-qin
CQ
Jin
Shao-hong
SH
D003460:Crystallization; D004791:Enzyme Inhibitors / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D000078142:Tazobactam; D014867:Water; D014961:X-Ray Diffraction; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry
D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D014867:Water; D010397:Penicillanic Acid; D001618:beta-Lactamases; D000078142:Tazobactam