[Lipid peroxidation of central nerve system in aged guinea pig and antioxidation effect of the method extract from Pegasus laternarius].
OBJECTIVE
To study the lipid peroxidation products level in aged animals central nerve system and the antioxidation effect of the methol extract from Pegasus laternarius.


METHODS
The lipid peroxidation product MDA was tested by spectrophotometer.


RESULTS
Compared with the 10 month-old guinea pig, the MDA in 32 month-old guinea pig central nerve system obviously elevated, there were some difference in different fields of tested guinea pig brain, the level of MDA in hypothalamus increased biggest (up to 161.7%), cerebral cortex 93.7%, cerebella 84.9%, brain stem 81.2%, spinal cord 90.7%, rest of the cerebrum 58.9%. The method extract from Pegasus laternarius 10, 20, 40 mg/kg and ginseng saponin 20 mg/kg could reduce the level of MDA in tested brain field of aged animals. The method extract from Pegasus laternarius had stronger activity in brain stem, spinal cord and hypothalamus.


CONCLUSIONS
The lipid peroxidation in aged animal may be increased, the method extract from Pegasus laternarius and ginseng saponin have a protective effect on neuron in central nerve system of aged animals from free radical hurt.
Xiang
Hui
H
Zhongshan University, Guangzhou 510275.
Li
Ruisheng
R
Liu
Wenhui
W
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005399:Fishes; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D008419:Materia Medica; D012503:Saponins