[Interferon-alpha 2b inhibits proliferation of human tenon capsule fibroblasts].
OBJECTIVE
To evaluate the potential effect of interferon-alpha 2b(IFN alpha-2b) as antifibrotic treatment after glaucoma filtering surgery.


METHODS
The MTT method was used to study the inhibitory effect of IFN alpha-2b on human Tenon capsule fibroblasts in vitro. The antimetabolites including 5-fluorouracil (5-FU), homoharringtonine(H.H) and mitomycin C(MMC) were also assessed.


RESULTS
The IC50 values of IFN alpha-2b, 5-FU, H.H and MMC on fibroblasts at 48 hours were 60.578 mg/L, 5.447 mg/L, 0.531 mg/L, 1.329 mg/L respectively.


CONCLUSIONS
The effect of IFN alpha-2b to inhibit proliferation of fibroblast was less than that of antimetabolites. Further investigation of other aspects of suppress(suppress) wound healing as a possible antifibrotic agent should be deserved.
Zhang
X
X
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guang zhou 510060, China.
Peng
D
D
Zeng
S
S
Zheng
J
J
D000963:Antimetabolites / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003228:Conjunctiva / Q000166:cytology* / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D018463:Filtering Surgery; D005472:Fluorouracil / Q000494:pharmacology; D005901:Glaucoma / Q000473:pathology / Q000601:surgery; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D016685:Mitomycin / Q000494:pharmacology; D011994:Recombinant Proteins
D000963:Antimetabolites; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016685:Mitomycin; D005472:Fluorouracil