Dynamic change in plasma leptin level during the perioperative period.
OBJECTIVE
To examine the association of plasma leptin level with insulin, which is known as a metabolic regulator of leptin, and various stress-related factors during the perioperative period.


METHODS
Thirty-one patients undergoing gastrectomy were enrolled and blood samples were obtained preoperatively, intraoperatively, immediately after operation, and on the first and second postoperative days.


RESULTS
The plasma leptin level showed a triphasic response. Immediately after operation, the leptin level was the lowest, while the serum cortisol and interleukin-6 (IL-6) levels had their peak (PHASE 1). On the first postoperative day, the leptin level had its peak with the serum cortisol and IL-6 level remaining elevated (PHASE 2). On the second postoperative day, while the serum cortisol and IL-6 levels still remained elevated, the plasma leptin level fell to the preoperative value (PHASE 3). The plasma leptin level correlated well with the insulin level at all time points during the study period.


CONCLUSIONS
Our results suggest a possible role of leptin in harmonizing neuroendocrine and immune responses with energy balance.
Cho
Young Min
YM
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim
Min Seon
MS
Shin
Chan Soo
CS
Park
Do Joon
DJ
Park
Kyong Soo
KS
Yang
Han-Kwang
HK
Lee
Kuhn Uk
KU
Cho
Bo Youn
BY
Lee
Hong Kyu
HK
Kim
Seong-Yeon
SY
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007432:Intraoperative Period; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013312:Stress, Physiological / Q000097:blood; D013514:Surgical Procedures, Operative; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone