Cytogenetic study of non-Hodgkin lymphoma from South India. histologic and geographic correlations.
Cytogenetic analysis of fine needle aspiration cultures was performed on 189 patients with non-Hodgkin lymphoma from South India. Successful karyotyping was possible in 97 patients (51.3%). Burkitt lymphoma constituted 56% of the cases studied followed by diffuse type 20%, follicular 8.8%, lymphoblastic 6.6%, and unclassified 6.6%. Characteristic chromosomal translocations were t(8;14)(q24;q32) [32.2%], t(8;22)(q24;q11) [10%], t(2;8)(p12;q24) [2.2%], t(14;18)(q34;q21) [3.3%], and t(11;14)(q23;q32) [2.2%]. Notable geographical variation of some structural abnormalities was the finding in the present study such as, lower frequency of t(14;18) in follicular lymphomas and higher frequency of t(8;14) in Burkitt lymphomas when compared with the Western studies.
Kumari
Prasanna
P
Department of Pathology, Kidwai Memorial Institute of Oncology, 560 029, Bangalore, India.
Mukherjee
Geetashree
G
Rao
Clementina Rama
CR
Devi
Muniyappa Gayathri
MG
Biswas
Siddhartha
S
Appaji
Lingegowda
L
Arunakumari
Bandagadde S
BS
Padma
Maneya
M
Bapsy
Poonamallee Parthasarthy
PP
Sundareshan
Tambarahalli S
TS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000453:epidemiology / Q000235:genetics; D008224:Lymphoma, Follicular / Q000453:epidemiology / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged