[p27 protein expression and its significance in human laryngeal carcinoma].
OBJECTIVE
To determine clinical significance and expression of p27 protein in human laryngeal carcinoma tissue.


METHODS
To measure p27 protein expression in 50 cases laryngeal carcinoma tissue by immunohistochemical LSAB (labelled streptavidin biotin) method, 15 cases vocal cord polyps used as control.


RESULTS
There was significant difference between p27 protein expression in laryngeal carcinoma and in vocal cord polyps, among pathological staging of laryngeal carcinoma (G1-G2 and G3), between the survived and the dead laryngeal carcinoma patients 3 years after operation, but no significant difference among clinical staging and between the patients with and without lymph node metastases. There was significant difference between the survival rate curves (Kaplan-meier curve) in p27 protein expression positive group and that in p27 protein expression negative group.


CONCLUSIONS
p27 Protein expression is related to malignant degree of laryngeal carcinoma, so it can be an important marker of identifying the malignancy and prognosis of laryngeal carcinoma.
Qin
X L
XL
Department of Otolaryngology, First University Hospital of West China, University of Medical Sciences, Chengdu 610041.
Guo
Q H
QH
Zheng
H
H
Zheng
Y
Y
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009124:Muscle Proteins; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
D008840:Microfilament Proteins; D009124:Muscle Proteins; C058992:Tagln protein, mouse