[Study on inhibitory actions of san huang yi gan capsule (SHYGC) on HBeAg with seropharmacological method].
In this paper, the inhibitory actions of SHYGC on HBeAg in vitro were studied with the seropharmacological method. By Enzyme Linked Immuno Sorbent Assay (ELISA), it was found that the rabbit sera containing SHYGC have significant inhibitory effects on HBeAg, and they become stronger with the drug concentration in sera improved and the actions time prolonged, they decrease with the HBeAg concentration improved, and the effects of the sera containing hing-dose drugs equal those of Su Xiao Jing containing 250 micrograms/g effective chloric. The direct external inhibitory effects of SHYGC in original pharmaceutics are stronger than those of the sera containing drugs. It probably indicated that the active ingredients of SHYGC could not be digested and absorbed completely from gastrointestine, or were inactived by metabolism in vivo.
Wu
Q
Q
Guangzhou University of TCM, Guangzhou 510405.
Rong
X
X
Huang
P
P
Han
J
J
Xu
H
H
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006513:Hepatitis B e Antigens / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits
D000998:Antiviral Agents; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006513:Hepatitis B e Antigens