Chemotherapeutic targeting of etoposide to regions of the brain on the basis of polyamine level.
The effects of etoposide on body weight, regional weights, and the concentrations of putrescine, spermidine and spermine in the cerebellum, hippocampus, corpus striatum, cortex, the combined regions of the thalamus and hypothalamus and the diencephalon of the brain were examined in rats. Etoposide seems to be a better choice for management of cortical and hippocampal tumors because it reduces polyamines, which are associated with tumor cell growth, but not for the management of tumors of the diencephalon and corpus striatum because it increases polyamines.
Watanabe
Satoru
S
Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan. sunsw@med.kawasaki-m.ac.jp
Sato
Shoichi
S
Nagase
Sumika
S
Shimosato
Kazuaki
K
Ohkuma
Seitaro
S
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D005047:Etoposide / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011073:Polyamines; D005047:Etoposide