title: Return of the chalones.
abstract: Members of the TGFbeta superfamily play many roles in embryonic development and adult tissue homeostasis. Now recent work focused on growth and differentiation factors (GDFs) suggest that these TGFbeta-like molecules may also control organ size and may, in fact, be the long sought after chalones, or negative growth regulators.
authors.affiliation: Department of Oral and Developmental Biology, Harvard School of Dental Medicine and The Forsyth Institute, Boston, MA 02115, USA.
authors.forename: Laura W
authors.initials: LW
authors.lastname: Gamer
authors.forename: John
authors.initials: J
authors.lastname: Nove
authors.forename: Vicki
authors.initials: V
authors.lastname: Rosen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division / Q000502:physiology; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D006131:Growth Inhibitors; D016212:Transforming Growth Factor beta