[Experimental study on anti-oxygen and promoting intelligence development of Codonopsis lanceolata in old mice].
The water labyrinth test and determining lipid peroxide (LPO) contents were used to assay the effects of Codonopsis lanceolata on promoting intelligence development and lipid peroxide. The results showed that latent period of old mice in water labyrinth was statistically shorten and the number of mistake of old mice was visibly reduced by drinking extraction of Codonopsis lanceolate 4 g/kg and 8 g/kg. These indicated that mice drinking extraction of Codonopsis lanceloata learned faster that those of drinking water. The contents of LPO in red blood cell and brain of mice and rate drinking extraction of Codonopsis lanceolata were significantly reduced, the activities of superoxide dismutase (SOD) in serum of rat drinking extraction of Codonopsis lanceolata were visibly increased. These presents that the extraction of Codonopsis lanceolata has the role of promoting learning and memory of old animal, its mechanism might be increasing SOD activity and decreasing LPO level.
Han
C
C
College of Medicine, Yanbian University, Yanji 133000.
Li
L
L
Piao
K
K
Shen
Y
Y
Piao
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism; D029745:Codonopsis; D004912:Erythrocytes / Q000378:metabolism; D007360:Intelligence / Q000187:drug effects*; D007361:Intelligence Tests; D015227:Lipid Peroxidation / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
D010936:Plant Extracts; D013482:Superoxide Dismutase