title: Increased interleukin-6 in aqueous humor of a patient with lung-metastatic intraocular adenocarcinoma.
abstract: OBJECTIVE
  We report increased interleukin (IL)-6 level in aqueous humor of a case of lung adenocarcinoma with metastasis to iris and anterior chamber.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  In one case and 11 healthy cataract patients as controls, we checked the levels of IL-6, IL-2, and tumor necrosis factor (TNF)-alpha in aqueous humor and serum by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Levels of these three cytokines in serum were almost the same as with the levels in aqueous humor in the control group. The IL-6 concentrations ranged from 12.6 to 27.0 pg/ml (mean, 23.5 pg/ml) in serum and 15.0 to 43.1 pg/ml (mean, 22.4 pg/ml) in aqueous humor. There was no statistically significant difference between them. Compared with the control, the IL-6 concentration in aqueous humor of this patient, 282.0 pg/ml, increased more than 10-fold.
  
  
  CONCLUSIONS
  This is a report describing elevated IL-6 level in the aqueous humor of a patient with intraocular metastasis from lung adenocarcinoma.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, Section II, Taipei, Taiwan, Republic of China. khchen@vghtpe.gov.tw
authors.forename: Ko-Hua
authors.initials: KH
authors.lastname: Chen
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Hsu
authors.forename: Chih-Chiau
authors.initials: CC
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology / Q000528:radiation effects; D001082:Aqueous Humor / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D015811:Iris Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha