title: Central nervous system activity of the methanol extract of Ficus platyphylla stem bark.
abstract: The central nervous system (CNS) activity of the methanolic extract of Ficus platyphylla stem bark was studied on locomotor activity, pentobarbital sleeping time, exploratory behaviour, amphetamine-induced hyperactivity, apomorphine-induced stereotypy, active-avoidance and performance on tread mills (rota-rod), using mice and rats. The results revealed that the extract significantly reduced the locomotor and exploratory activities in mice, prolonged pentobarbital sleeping time in rats, attenuated amphetamine-induced hyperactivity and apomorphine-induced stereotypy in mice, dose-dependently. The extract significantly suppressed the active-avoidance response in rats, with no significant effect on motor co-ordination as determined by the performance on rota-rod. The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M. B. 21, Abuja, FCT, Nigeria.
authors.forename: B A
authors.initials: BA
authors.lastname: Chindo
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: A A
authors.initials: AA
authors.lastname: Odutola
authors.forename: H O
authors.initials: HO
authors.lastname: Vongtau
authors.forename: J
authors.initials: J
authors.lastname: Abbah
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K S
authors.initials: KS
authors.lastname: Gamaniel
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D030681:Ficus; D008297:Male; D000432:Methanol; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
chemical_list: D002491:Central Nervous System Agents; D010936:Plant Extracts; D000432:Methanol