title: Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
abstract: Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.
authors.affiliation: Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Hong
authors.forename: Seok-Hee
authors.initials: SH
authors.lastname: Chung
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hyun-Dae
authors.initials: HD
authors.lastname: Shin
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Young-Pyo
authors.initials: YP
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test / Q000379:methods; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D029596:Paeonia; D010805:Physical Conditioning, Animal / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000096:biosynthesis*
chemical_list: D010936:Plant Extracts; D012701:Serotonin; D014365:Tryptophan Hydroxylase