Prevention of free-radical mediated tissue damage and carcinogenesis induced by low-molecular-weight iron.
The unique model of iron-induced oxidative nephrotoxicity and renal cancer can be used to screen possible bioprotective substances in vivo. Ferric iron complexed with nitrilotriacetic acid (Fe-NTA) in this model is thought to be a tumor initiator as well as a promoter through the production of active oxygen species/free radicals. In the present paper, I have summarized the animal studies using this model of chemoprevention, and present some of new studies.
Okada
Shigeru
S
Department of Pathological Research, Faculty of Medicine, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
D000818:Animals; D002273:Carcinogens; D002292:Carcinoma, Renal Cell / Q000139:chemically induced; D005290:Ferric Compounds / Q000633:toxicity*; D005609:Free Radicals / Q000633:toxicity; D007501:Iron / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007680:Kidney Neoplasms / Q000139:chemically induced; D009369:Neoplasms / Q000139:chemically induced*; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity*; D018962:Phlebotomy; D051381:Rats; D017208:Rats, Wistar
D002273:Carcinogens; D005290:Ferric Compounds; D005609:Free Radicals; D007501:Iron; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate