Developments in restenosis.
Restenosis is a major complication leading to the failure of vascular procedures, including surgery, angioplasty and stenting. Major efforts including over 100 clinical trials have been made to overcome this complication, with little success to date. Issues relating to trial rationale, design, measurement and biology are addressed in this review.
Chan
Philip
P
Clinical Sciences Centre, Northern General Hospital, Sheffield, S5 7AU, UK. p.chan@sheffield.ac.uk
D000818:Animals; D002309:Cardiology / Q000639:trends; D023903:Coronary Restenosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D023921:Coronary Stenosis / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology