Intramolecular titanium-mediated aminocyclopropanation of terminal alkenes: easy access to various substituted azabicyclo[n.1.0]alkanes.
[reaction: see text] A variety of substituted azabicyclo[n.1.0]alkanes were synthesized by intramolecular titanium-mediated cyclopropanation of N-benzyl-N-(2-alkylalk-3-enyl)formamides and N-benzyl-N-alkadienylformamides. N-Benzylpyrroline upon treatment with Grignard reagents undergoes a titanium-mediated carbomagnesiation to yield N-benzyl-N-(2-alkylbut-3-enyl)amines.
Tebben
Gerd-Dieter
GD
Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Rauch
Karsten
K
Stratmann
Christian
C
Williams
Craig M
CM
de Meijere
Armin
A