Effect of heavy ions on neuro-endocrine regulations.
During American and Russian short and long-term space flights neuroimmune dysregulations have been observed in man and rats for up to three months after the return. During Extra-Vehicular Activity, radiation exposure risk is greater to elicit short and/or long-term deleterious effects on the functional capacity of the neuroimmune system. In order to assess the effects of high LET events on neuroimmune networks, our preliminary ground-based study was to investigate brain inflammatory responses in mouse after low dose radiation exposure with high LET particles (12C, 95MeV/u, 42 mGy). Plasma corticosterone levels were rapidly (6 hours) increased by two-fold, then decreased 24 hours post-irradiation. At 3 days plasma corticosterone and ACTH concentrations were also two- to three-fold increased. Plasma ACTH levels were still elevated up to seven days to two months. Furthermore immune functions are under current assessment. The results of this study should allow a greater understanding of the effects of high LET particles on neuroimmune system.
Lebaron-Jacobs
L
L
Institute of Protection and Nuclear Safety (IPSN), Fontenay aux Roses, France.
Wysocki
J
J
Clarencon
D
D
Mathieu
J
J
Maubert
C
C
Aigueperse
J
J
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism* / Q000528:radiation effects; D000818:Animals; D002244:Carbon; D003345:Corticosterone / Q000097:blood / Q000378:metabolism* / Q000528:radiation effects; D004487:Edema / Q000473:pathology; D004702:Endocrine Glands / Q000378:metabolism / Q000528:radiation effects*; D018478:Extravehicular Activity; D005123:Eye / Q000473:pathology / Q000528:radiation effects; D020450:Heavy Ions; D018499:Linear Energy Transfer; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009490:Neurosecretory Systems / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D002244:Carbon; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone