title: Dynamic change in plasma leptin level during the perioperative period.
abstract: OBJECTIVE
  To examine the association of plasma leptin level with insulin, which is known as a metabolic regulator of leptin, and various stress-related factors during the perioperative period.
  
  
  METHODS
  Thirty-one patients undergoing gastrectomy were enrolled and blood samples were obtained preoperatively, intraoperatively, immediately after operation, and on the first and second postoperative days.
  
  
  RESULTS
  The plasma leptin level showed a triphasic response. Immediately after operation, the leptin level was the lowest, while the serum cortisol and interleukin-6 (IL-6) levels had their peak (PHASE 1). On the first postoperative day, the leptin level had its peak with the serum cortisol and IL-6 level remaining elevated (PHASE 2). On the second postoperative day, while the serum cortisol and IL-6 levels still remained elevated, the plasma leptin level fell to the preoperative value (PHASE 3). The plasma leptin level correlated well with the insulin level at all time points during the study period.
  
  
  CONCLUSIONS
  Our results suggest a possible role of leptin in harmonizing neuroendocrine and immune responses with energy balance.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Cho
authors.forename: Min Seon
authors.initials: MS
authors.lastname: Kim
authors.forename: Chan Soo
authors.initials: CS
authors.lastname: Shin
authors.forename: Do Joon
authors.initials: DJ
authors.lastname: Park
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.forename: Kuhn Uk
authors.initials: KU
authors.lastname: Lee
authors.forename: Bo Youn
authors.initials: BY
authors.lastname: Cho
authors.forename: Hong Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Seong-Yeon
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007432:Intraoperative Period; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013312:Stress, Physiological / Q000097:blood; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone