Sickle cell disease and the kidney.
Sickle cell disease (SCD) affects the kidney by acute mechanisms, as a form of the sickle crisis, and insidiously with renal medullary/papillary necrosis, with resulting tubular defects. Glomerular hyperperfusion and hypertrophy results in a chronic sickle cell nephropathy that results in a significant morbidity in the progression to end-stage kidney disease. Kidney transplantation offers a major advantage to survival, and should be coupled with efforts toward prevention of recurrent disease.
Scheinman
Jon I
JI
Division of Nephrology, University of Kansas Medical Center, Kansas University Childrens Center, Kansas City, KS, USA. jscheinman@kumc.edu
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000453:epidemiology; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate