Is the central channel of nuclear pore complex really the exclusive gateway for macromolecular transport?
Examination of many nuclear pore complexes revealed in some of them very thin filaments presumably RNA with accompanying proteins, directing from inner nucleus to the edge of the complex. On one representative micrograph it is shown that this strand continues in the same direction through central part of the complex most probably through the peripheral channel. Next route of the strand is through the tunnel of a hollow rod - subunit of the cytoplasmic ring.
Prachar
J
J
Cancer Research Institute, Bratislava, Slovakia. jarmil.prachar@savba.sk
D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm; D007473:Ion Channels / Q000502:physiology; D007938:Leukemia / Q000473:pathology; D046911:Macromolecular Substances; D051379:Mice; D017348:Microscopy, Electron, Scanning Transmission; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D022022:Nuclear Pore / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism* / Q000648:ultrastructure
D007473:Ion Channels; D046911:Macromolecular Substances; D009687:Nuclear Proteins