title: [Molecular biological analysis of Tinea faciei caused by a clinically anomalous strain of Trichophyton mentagrophytes].
abstract: We report a case of Trichophyton mentagrophytes infection. A 27-year-old female dairy worker visited our hospital in August 2001 for evaluation of an erythematous lesion near her right eye. The patient had been treated with antibiotics and an anti-allergic drug at another clinic with no effect on the lesion. KOH preparation of the scale revealed mycelia and T. mentagrophytes was isolated from the culture. The isolated pathogen was identified as T. mentagrophytes animal type 1 by the classification system based on the cluster analysis of nuclear ribosomal internal transcribed spacer 1 (ITS1) DNA sequences. The oral administration of terbinafine at 125 mg/day and antifungal cream was effective. T. mentagrophytes is one of the most common dermatophytes isolated from humans and animals. We should be aware that animals may carry this kind of fungal pathogen.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kaneko
authors.forename: Masataro
authors.initials: M
authors.lastname: Hiruma
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Makimura
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D021901:DNA, Intergenic; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D005145:Face; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage; D009281:Naphthalenes / Q000008:administration & dosage; D000077291:Terbinafine; D014005:Tinea / Q000188:drug therapy / Q000382:microbiology*; D016896:Treatment Outcome; D014249:Trichophyton / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D021901:DNA, Intergenic; D021903:DNA, Ribosomal Spacer; D009281:Naphthalenes; D000077291:Terbinafine; D007654:Ketoconazole