Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times.
A methodology is presented for extracting precise quantitative MT parameters using a magnetisation-prepared spoiled gradient echo sequence. This method, based on a new mathematical model, provides relaxation parameters for human brain in-vitro and in-vivo. The in-vivo parameters have been obtained from three different regions of normal white matter: occipital white matter, frontal white matter and centrum semiovale; two regions of normal grey matter: cerebral cortex and cerebellum, and from five regions with MS lesions. All this has been achieved using MT images collected within a timeframe that is clinically feasible. We hope that this new technique will shed light on the properties and dynamics of water compartments within the brain.
Ramani
A
A
NMR Research Unit, Dept. Clinical Neurology, Institute of Neurology, Queen's Square, University College London, London, WC1N 3BG, England. a.ramani@nmr.ion.ucl.ac.uk
Dalton
C
C
Miller
D H
DH
Tofts
P S
PS
Barker
G J
GJ
D001921:Brain / Q000033:anatomy & histology / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology