Absence of SCL mutations in myeloid malignancies.
Transcription factors play a central role in the pathogenesis of acute leukaemia. Genes encoding transcription factors are frequently perturbed by chromosome rearrangements. More recently acquired point mutations have been described in a number of important genes for normal haematopoiesis. The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix transcription factor and is upregulated by chromosome rearrangements in T-acute lymphoblastic leukaemia. SCL function is essential for the development of both primitive and definitive haematopoiesis. We searched for SCL mutations in myeloid leukaemias and chronic myeloproliferative disorders. Our data demonstrated that SCL point mutations were rare in acute myeloid leukaemia and myeloproliferative disorders.
Delabesse
Eric
E
University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge, UK.
Li
Juan
J
Schnittger
Susanne
S
Hiddemann
Wolfgang
W
Green
Anthony R
AR
D000208:Acute Disease; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000235:genetics*; D018257:Helix-Loop-Helix Motifs / Q000235:genetics; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics; D017354:Point Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C067143:TAL1 protein, human