title: A case of multiple keratoacanthoma centrifugum marginatum: response to oral etretinate.
abstract: The patient was a 48-year-old man who had a history of colonic polyps. About 18 months before, a dark reddish nodule had appeared on his right forearm. By peripheral growth, this lesion had formed a crateriform prominence with central healing. Similar symptoms multiplied and expanded, the largest being about the size of a child's head. Given both the clinical and histologic evidence, a diagnosis of keratoacanthoma centrifugum marginatum (KCM) was made. Oral etretinate was administered, and an involution of verrucous plaque began after 4 weeks. After 8 weeks, the lesions faded, leaving pigmentation in some areas. This is a rare disorder, only 30 such cases having been reported worldwide, and the present case was the third in which oral etretinate was found to be effective.
authors.affiliation: Department of Dermatology and Biomolecular Recognition, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan. yumie@po.cc.yamaguchi-u.ac.jp
authors.forename: Yumie
authors.initials: Y
authors.lastname: Ogasawara
authors.forename: Emi
authors.initials: E
authors.lastname: Kinoshita
authors.forename: Toshiko
authors.initials: T
authors.lastname: Ishida
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hamamoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Fujiyama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Muto
mesh_terms: D000284:Administration, Oral; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007636:Keratoacanthoma / Q000188:drug therapy* / Q000473:pathology; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007866:Leg; D008297:Male; D008875:Middle Aged
chemical_list: D007641:Keratolytic Agents; D005050:Etretinate