Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action.
Oral pretreatment of rats with G. cambogia fruit extract (1 g/kg body weight/day at interval of 7 and 15 days) protected gastric mucosa against HCl-ethanol induced damage by decreasing the volume and acidity of gastric juice. Increased lipid peroxidation, decreased activity of antioxidant enzymes, altered levels of protein and glycoproteins in the ulcerated mucosa, and gastric juice were maintained at near normal levels in G. cambogia pretreated rats. The results suggest the anti-ulcer activity of G. cambogia by virtue of its ability to decrease acidity and increase mucosal defense.
Mahendran
P
P
Department of Biochemistry & Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
Sabitha
K E
KE
Devi
C S Shyamala
CS
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000431:Ethanol / Q000633:toxicity; D005638:Fruit / Q000737:chemistry*; D029761:Garcinia cambogia; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects; D006023:Glycoproteins / Q000378:metabolism; D006851:Hydrochloric Acid / Q000633:toxicity; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D006023:Glycoproteins; D010936:Plant Extracts; D000431:Ethanol; D006851:Hydrochloric Acid