title: A support vector machine approach for detection of microcalcifications.
abstract: In this paper, we investigate an approach based on support vector machines (SVMs) for detection of microcalcification (MC) clusters in digital mammograms, and propose a successive enhancement learning scheme for improved performance. SVM is a machine-learning method, based on the principle of structural risk minimization, which performs well when applied to data outside the training set. We formulate MC detection as a supervised-learning problem and apply SVM to develop the detection algorithm. We use the SVM to detect at each location in the image whether an MC is present or not. We tested the proposed method using a database of 76 clinical mammograms containing 1120 MCs. We use free-response receiver operating characteristic curves to evaluate detection performance, and compare the proposed algorithm with several existing methods. In our experiments, the proposed SVM framework outperformed all the other methods tested. In particular, a sensitivity as high as 94% was achieved by the SVM method at an error rate of one false-positive cluster per image. The ability of SVM to out perform several well-known methods developed for the widely studied problem of MC detection suggests that SVM is a promising technique for object detection in a medical imaging application.
authors.affiliation: Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
authors.forename: Issam
authors.initials: I
authors.lastname: El-Naqa
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Yang
authors.forename: Miles N
authors.initials: MN
authors.lastname: Wernick
authors.forename: Nikolas P
authors.initials: NP
authors.lastname: Galatsanos
authors.forename: Robert M
authors.initials: RM
authors.lastname: Nishikawa
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001941:Breast Diseases / Q000145:classification / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000145:classification / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000145:classification / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D010363:Pattern Recognition, Automated; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity