[Relationship between endotoxemia and APACHE-III scoring and integrated therapy of Chinese and Western medicine].
OBJECTIVE
To explore the relationship between endotoxemia and the severity of disease condition and therapeutic effect.


METHODS
According to randomized controlled principle, the 153 acute infectious patients were divided into simple antibiotics treated group and antibiotics plus Chinese drugs combined treated group, and patients in each group were subdivided into 3 types according to acute physiology and chronic health evaluation (APACHE-III) scoring: type A (APACHE-III scoring < or = 20 points), type B (APACHE-III scoring 21-40 points) and type C (APACHE-III scoring > 40 points). The 77 cases in the simple treated group were 40 males and 37 females, aging 18-76 years, mean 46.5 +/- 27.5 years, 41 cases of type A, 28 of type B and 8 of type C, treatment course 10-14 days, mean 11.5 +/- 2.5 days. The 76 cases in the combined treated group were 39 males and 37 females, aging 18-70 years, mean 44.5 +/- 25.5 years, 37 of type A, 30 of type B and 9 of type C, treatment course 10-14 days, mean 10.5 +/- 2.5 days. Limulus test was used to determine the endotoxin content in peripheral blood of patients, and further analysis on the relationship between endotoxemia and APACHE-III scoring was conducted.


RESULTS
Acute severe infectious patients whose APACHE-III scoring > 20 points occurred endotoxemia (P < 0.05), and the condition of disease was positively related to the APACHE-III scoring (r = 0.718, P < 0.05). Chinese drugs plus antibiotics can obviously alleviate endotoxemia (P < 0.05) and improve the prognosis of patients.


CONCLUSIONS
Endotoxemia can serve as a referential parameter for predicting the severity of disease. Integrated therapy of Chinese and western medicine in treating bacterial infection revealed better results than that of antibiotics solely.
Duan
M L
ML
Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050.
Zhang
S W
SW
Ci
X L
XL
D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D002764:Cholecystitis / Q000188:drug therapy / Q000382:microbiology; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019446:Endotoxemia / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology; D011112:Polymyxin B / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D011112:Polymyxin B