Myxovirescin analogues via macrocyclic ring-closing metathesis.
A short, efficient route has been developed to analogues of myxovirescin using ring-closing metathesis whereby the antibacterial activity has been retained.
Content
Stéphane
S
Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK.
Dutton
Christopher J
CJ
Roberts
Lee
L
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003500:Cyclization; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016940:Myxococcus / Q000737:chemistry
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D007783:Lactones; C036969:myxovirescin A