title: Efficacy of eprinomectin pour-on against gastrointestinal nematode infections in sheep.
abstract: Two field trials were conducted in two farms (farms A and B) in southern Italy, to assess the efficacy of eprinomectin applied topically at the dose rate of 500 micro g/kg to sheep with naturally occurring infections of gastrointestinal nematodes (GIN). The nematode population determined by necropsy consisted of Teladorsagia circumcincta, Haemonchus contortus, Trichostrongylus vitrinus, T. capricola, Nematodirus sp., and Chabertia ovina in sheep from farm A, and of T. circumcincta, T. vitrinus, T. capricola, T. colubriformis, and C. ovina in sheep from farm B. In each farm, 42 female sheep were assigned to a eprinomectin treated group (E-group) and a control untreated group (C-group) of 21 animals each. On farm A, the percentage reductions in strongyle faecal egg counts from E-group compared to C-group were 99.1% on day 10; 97.4% on day 30; and 67.0% on day 60. On farm B, on the same days, they were 95.4, 84.9, and 69.4%, respectively. In the course of the two trials, eprinomectin was well tolerated by all the animals with no adverse reactions following the topical treatment.
authors.affiliation: Dipartimento di Patologia e Sanità Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Napoli "Federico II", Via Della Veterinaria 1, 80137, Napoli, Italy. cringoli@unina.it
authors.forename: G
authors.initials: G
authors.lastname: Cringoli
authors.forename: L
authors.initials: L
authors.lastname: Rinaldi
authors.forename: V
authors.initials: V
authors.lastname: Veneziano
authors.forename: G
authors.initials: G
authors.lastname: Capelli
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007558:Italy; D007559:Ivermectin / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D009348:Nematoda / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy* / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology*; D034561:Sheep, Domestic / Q000469:parasitology*
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin