The effect of taste stimuli on histamine release in the anterior hypothalamus of rats.
We studied the effect of gustatory stimulation on hypothalamic histamine release. Administering a four-basic taste mixture significantly increased histamine release, but not in the chorda tympani-transected rats. 0.1 M NaCl significantly increased histamine release, whereas 0.5 M sucrose, 0.02 M quinine HCl and 0.01 M HCl had no effect. However, when the concentration of HCl was increased to 0.03 M, a significant increase in histamine release was seen. These results suggest that taste information via the chorda tympani activates the histaminergic system.
Treesukosol
Yada
Y
Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University, Osaka 565-0871, Japan.
Ishizuka
Tomoko
T
Yamamoto
Takashi
T
Yamatodani
Atsushi
A
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000378:metabolism*; D002814:Chorda Tympani Nerve / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000378:metabolism*; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010812:Physical Stimulation; D011803:Quinine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012965:Sodium Chloride / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000187:drug effects* / Q000502:physiology; D017833:Visceral Afferents / Q000187:drug effects* / Q000502:physiology
D012965:Sodium Chloride; D013395:Sucrose; D006632:Histamine; D011803:Quinine; D006851:Hydrochloric Acid