title: [Study on the permeability of 125I-sinomenine via the transdermal delivery way in rats].
abstract: OBJECTIVE
  To study the permeance and diffusion trend of 125I-sinomenine via the transdermal delivery way in rats.
  
  
  METHODS
  Assay the permeance depth and diffusion area of sinomenine labeled by isotopic 125I in subcutaneous of rats certain time after sinomenine was administrated on the cervical skin of rats.
  
  
  RESULTS
  The diffuse of sionmenine can reach cervical spine in longitudinal direction and form an area of 2 cm2 in transverse direction. The concentration gradient of both directions are significant.
  
  
  CONCLUSIONS
  125I-sinomenine can not only be absorbed into blood via the transdermal delivery way to have whole effect, but also accumulate large amounts in the skin to have a local effect.
authors.affiliation: ShangHai University of Traditional Chinese Medicine, Shanghai 200032.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Lianying
authors.initials: L
authors.lastname: Xu
authors.forename: Peikang
authors.initials: P
authors.lastname: Xu
authors.forename: Gaoren
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D009019:Morphinans / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032841:Sinomenium / Q000737:chemistry*; D012869:Skin Absorption
chemical_list: D004365:Drugs, Chinese Herbal; D007457:Iodine Radioisotopes; D009019:Morphinans; C009271:sinomenine