title: Predicting angiographic distal embolization following percutaneous coronary intervention in patients with acute myocardial infarction.
abstract: The aim of this study was to investigate the relation between lesion morphology identified by intravascular ultrasound (IVUS) before intervention and angiographic distal embolization after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). PCI for AMI has already been established as beneficial therapy, although some complications remain unresolved. Distal embolization is 1 of the important complications of PCI. Recently, some new devices have been developed for the prevention of distal embolization. However, few studies exist that look into the relation between lesion morphology and distal embolization. IVUS was performed safely in 140 consecutive patients with AMI before coronary intervention. No patient received thrombolytic therapy. From the incidence of angiographic distal embolization, patients were divided into 2 groups--an embolization group and a nonembolization group--and clinical background, IVUS, and angiographic information were evaluated. Distal embolization was observed in 12 patients (9%). Peak creatine kinase levels (3,877 +/- 2,285 vs 2,293 +/- 1,792 IU/L, p <0.05) and the incidence of angiographic thrombus (25% vs 5%, p <0.05) and intracoronary mobile mass detected by IVUS (75% vs 16%, p <0.001) were higher for patients in the embolization group. From the multivariate logistic regression analysis, only an intracoronary mobile mass detected by IVUS emerged as a predictor of distal embolization (odds ratio 53, 95% confidence interval 2.7 to 1,040, p <0.01). Patients with an intracoronary mobile mass detected by IVUS are prone to distal embolization after PCI and larger infarction. IVUS imaging before PCI may be useful for determining which patients need a distal protection device.
authors.affiliation: Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan. daiju@qg7.so-net.ne.jp
authors.forename: Daiju
authors.initials: D
authors.lastname: Fukuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishida
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000592:standards*; D003402:Creatine Kinase / Q000097:blood; D004617:Embolism / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000628:therapy*; D011237:Predictive Value of Tests; D012307:Risk Factors; D016037:Single-Blind Method; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000592:standards*; D020257:Ventricular Remodeling
chemical_list: D003402:Creatine Kinase