title: [Structures and pharmacological activities of beesiosides O and P].
abstract: OBJECTIVE
  To investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components.
  
  
  METHODS
  Compounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation.
  
  
  RESULTS
  Two novel compounds were isolated and identified as (20S, 24S)-15 alpha-acetoxy-16 beta, 24; 20, 24-diepoxy-9, 19-cyclolanostane-3 beta, 25-diol-3-O-beta-D-xylopyranoside (I) and (20S, 24R)-15 alpha-acetoxy-9, 19-cyclolanostane-3 beta, 16 beta, 20, 24, 25-pentaol-3-O-beta-D-xylopyranoside (II), named beesioside O and beesioside P.
  
  
  CONCLUSIONS
  Compounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. junshanyang@hotmail.com
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Ju
authors.forename: Geng
authors.initials: G
authors.lastname: Lin
authors.forename: Jun-shan
authors.initials: JS
authors.lastname: Yang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Lu
authors.forename: Bing-na
authors.initials: BN
authors.lastname: Ma
authors.forename: Shu-qin
authors.initials: SQ
authors.lastname: Nie
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D029626:Ranunculaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C486138:15-acetoxy-16,24-20,24-diepoxy-9,19-cyclolanostane-3,25-diol-3-O-xylopyranoside; C486139:15-acetoxy-9,19-cyclolanostane-3,16,20,24,25-pentaol-3-O-xylopyranoside; D020533:Angiogenesis Inhibitors; D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D012503:Saponins