Genetic Network Analyzer: qualitative simulation of genetic regulatory networks.
BACKGROUND
The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes.


RESULTS
We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis.


BACKGROUND
GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna.
de Jong
Hidde
H
INRIA Rhône-Alpes, 655 avenue de l'Europe, Montbonnot, 38334 Saint Ismier CEDEX, France. Hidde.de-Jong@inrialpes.fr
Geiselmann
Johannes
J
Hernandez
Céline
C
Page
Michel
M
D001412:Bacillus subtilis / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D005796:Genes / Q000502:physiology; D023281:Genomics / Q000379:methods; D008957:Models, Genetic; D012984:Software; D013171:Spores, Bacterial / Q000502:physiology
D001426:Bacterial Proteins