title: Blood flow and muscle metabolism in chronic fatigue syndrome.
abstract: The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced blood flow and oxidative delivery to skeletal muscle. Patients with CFS according to CDC (Center for Disease Control) criteria ( n =19) were compared with normal sedentary subjects ( n =11). Muscle blood flow was measured with Doppler ultrasound after cuff ischaemia and exercise. Muscle oxygen delivery was measured as the rate of post-exercise and post-ischaemic oxygen-haem resaturation. Oxygen-haem resaturation was measured in the medial gastrocnemius muscle using continuous wavelength near-IR spectroscopy. Muscle metabolism was measured using (31)P magnetic resonance spectroscopy. CFS patients and controls were not different in the peak blood flow after cuff ischaemia, the rate of recovery of phosphocreatine after submaximal exercise, and the rate of recovery of oxygen saturation after cuff ischaemia. In conclusion, CFS patients showed no deficit in blood flow or oxidative metabolism. This suggests that CFS symptoms do not require abnormal peripheral function.
authors.affiliation: Department of Exercise Science, University of Georgia, 300 River Road, Athens, GA 30602, U.S.A. kmccully@coe.uga.edu
authors.forename: Kevin K
authors.initials: KK
authors.lastname: McCully
authors.forename: Sinclair
authors.initials: S
authors.lastname: Smith
authors.forename: Sheeva
authors.initials: S
authors.lastname: Rajaei
authors.forename: John S
authors.initials: JS
authors.lastname: Leigh
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Natelson
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015673:Fatigue Syndrome, Chronic / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared; D018608:Ultrasonography, Doppler
chemical_list: D010100:Oxygen