title: Effect of ciprofloxacin on adhesive properties of non-P mannose-resistant uropathogenic Escherichia coli isolates.
abstract: The influence of sub-MIC of ciprofloxacin on the surface properties of 25 non-P mannose-resistant uropathogenic Escherichia coli (UPEC) strains was studied. Thirteen isolates responded to antibiotic treatment with an increase in haemagglutination titre and/or surface hydrophobicity, which correlated with a higher expression of surface proteins. Only UPEC strains with ciprofloxacin-enhanced hydrophobicity increased their adhesiveness to urinary catheters that correlated, in one analysed case, with a dramatic increase in the number of fimbriae peripherally located. The overall results indicate that sub-MICs of ciprofloxacin could increase the adhesiveness, and hence the risk of colonization by UPEC strains expressing mannose-resistant adhesins different from type P.
authors.affiliation: Department of Microbiology, Rosario University School of Biochemistry and Pharmacy, and Institute for Molecular and Cellular Biology (IBR-CONICET), Suipacha 531, Rosario 2000, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Balagué
authors.forename: Luisa
authors.initials: L
authors.lastname: Fernández
authors.forename: Jorgelina
authors.initials: J
authors.lastname: Pérez
authors.forename: Roberto
authors.initials: R
authors.lastname: Grau
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology; D002404:Catheterization; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000382:microbiology*; D006388:Hemagglutinins / Q000032:analysis; D006801:Humans; D008358:Mannose / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D014295:Trimethoprim / Q000494:pharmacology; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D018829:Adhesins, Bacterial; D000890:Anti-Infective Agents; D000892:Anti-Infective Agents, Urinary; D006388:Hemagglutinins; D002939:Ciprofloxacin; D014295:Trimethoprim; D008358:Mannose