Anti-tumor promoting effect of glycosides from Prunus persica seeds.
Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallocatechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN<COOH<H.
Fukuda
Toshiyuki
T
Faculty of Pharmaceutical Sciences, Okayama University, Kyoto, Japan.
Ito
Hideyuki
H
Mukainaka
Teruo
T
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Yoshida
Takashi
T
D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002273:Carcinogens / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D027861:Prunus; D012639:Seeds; D012878:Skin Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000956:Antigens, Viral; D000970:Antineoplastic Agents; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D006027:Glycosides; D010936:Plant Extracts