Anti-diabetes effect of Zn(II)/carnitine complex by oral administration.
A novel bis(L-carnitinato)Zn(II) complex, Zn(car)(2)Cl(2), was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight).
Yoshikawa
Yutaka
Y
Department of Chemistry, Graduate School of Science, Osaka City University, Japan.
Ueda
Eriko
E
Sakurai
Hiromu
H
Kojima
Yoshitane
Y
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002331:Carnitine / Q000008:administration & dosage* / Q000138:chemical synthesis*; D002712:Chlorides / Q000008:administration & dosage* / Q000138:chemical synthesis*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000138:chemical synthesis; D051379:Mice; D017967:Zinc Compounds / Q000008:administration & dosage* / Q000138:chemical synthesis*
D001786:Blood Glucose; D002712:Chlorides; D007004:Hypoglycemic Agents; D017967:Zinc Compounds; C016837:zinc chloride; D002331:Carnitine