Genomic approaches to identification of tumour-susceptibility genes using mouse models.
Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The sequencing of the mouse genome provides new approaches to one of the most challenging tasks of cancer genetics today.
Mao
Jian-Hua
JH
University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA. jmao@cc.ucsf.edu
Balmain
Allan
A
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D040641:Quantitative Trait Loci