Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents.
A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
Das
Saibal Kumar
SK
Discovery Chemistry, Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India. saibalkumardas@drreddys.com
Reddy
K Anantha
KA
Abbineni
Chandrasekhar
C
Iqbal
Javed
J
Suresh
J
J
Premkumar
M
M
Chakrabarti
Ranjan
R
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D015195:Drug Design; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011422:Propionates / Q000138:chemical synthesis*; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D010078:Oxazines; D011422:Propionates; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014280:Triglycerides