[Change in contractile vascular function in arterial hypertension of different genesis and its correction with phosphatidylcholine liposomes].
We examined the effects of phosphatidylcholine liposomes (PCL) upon the contractile vascular dysfunction in spontaneously hypertensive rats (SHR) and gamma-irradiated (60Co, 6 Gy) rats and rabbits. A significant impairment of endothelium-dependent relaxation was evident in both SHR and irradiated animals. An important novel finding of these experiments is that the impairment was mainly due to the loss of NO-dependent component of relaxation, with the component of relaxation mediated by EDHF being preserved. PCL were found to restore endothelium-dependent relaxation in both SHR and the irradiated vascular tissues. It is important to note that irradiated animals exhibited distinct and sustained signs of hypertension (blood pressure (BP) increased from 122 +/- 8 to 185 +/- 6 mm Hg). Being administered in a single dose of 30 mg/kg, 1 h after irradiation, PCL prevented hypertension development in an early post-irradiated period (9 days). At a later post-irradiated period (6 months), PCL in the single dose lost such a protective effect. Single administration of PCL in SHR led to a transient decrease in BP, but their repeated daily administration caused a persistent decrease in BP up to its normalization as early as in 4 days. These results suggest that PCL possess hypotensive activities due to their ability to normalize endothelial function.
Solovĭov
A I
AI
Institute of Pharmacology & Toxicology, Academy of Medical Sciences, Kiev.
Tyshkin
S M
SM
Khromov
O S
OS
Stefanov
O V
OV
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000528:radiation effects; D001794:Blood Pressure / Q000187:drug effects / Q000528:radiation effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000528:radiation effects; D006973:Hypertension / Q000503:physiopathology* / Q000517:prevention & control; D066298:In Vitro Techniques; D008081:Liposomes; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000528:radiation effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010713:Phosphatidylcholines / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011839:Radiation, Ionizing; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014664:Vasodilation / Q000187:drug effects* / Q000528:radiation effects; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D008081:Liposomes; D010713:Phosphatidylcholines; D014665:Vasodilator Agents; D009569:Nitric Oxide