title: In vivo evaluation of a MPC polymer coated continuous flow left ventricular assist system.
abstract: The aim of this study was the evaluation of the thrombogenicity and the biocompatibility of the SunMedical EVAHEART left ventricular assist system (LVAS) coated with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer compared to a diamond-like carbon (DLC) coating. Four calves were implanted with the MPC polymer-coated LVAS. Eight calves were implanted with DLC coated LVAS. The thrombogenicity and biocompatibility of the pumps were evaluated. At explant, 60.0 +/- 37.2% (5-85%) of the pump surface area was still coated with MPC polymer after the duration of 45.0 +/- 32.0 days. In 1 out of 4 MPC and 2 out of 8 DLC coated pumps, there was a very small amount of thrombus around the seal ring; otherwise the blood contacting surfaces were free of thrombus. Major organs were normal except for a few lesions in kidneys from both groups. The MPC polymer coated EVAHEART LVAS seems to have low thrombogenicity and high biocompatibility similar to the DLC coated system. The current study demonstrated that the MPC polymer coating shows great promise for being used as an antithrombogenic substrate for the LVAS due to its ease of application, significant cost benefit, and reduction in anticoagulation therapy in acute postoperative period.
authors.affiliation: Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 300 Technology Drive, Pittsburgh, PA 15219, U.S.A. kiharas@msx.upmc.edu
authors.forename: Shin'ichiro
authors.initials: S
authors.lastname: Kihara
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Litwak
authors.forename: Philip
authors.initials: P
authors.lastname: Litwak
authors.forename: Marina V
authors.initials: MV
authors.lastname: Kameneva
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ushiyama
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tokuno
authors.forename: David C
authors.initials: DC
authors.lastname: Borzelleca
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Umezu
authors.forename: Jun
authors.initials: J
authors.lastname: Tomioka
authors.forename: Osamu
authors.initials: O
authors.lastname: Tagusari
authors.forename: Takehide
authors.initials: T
authors.lastname: Akimoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Koyanagi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kurosawa
authors.forename: Robert L
authors.initials: RL
authors.lastname: Kormos
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena; D002244:Carbon; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000009:adverse effects; D006353:Heart-Assist Devices / Q000009:adverse effects; D008689:Methacrylates / Q000009:adverse effects; D010767:Phosphorylcholine / Q000009:adverse effects / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000209:etiology
chemical_list: D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; D002244:Carbon