Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines.
Plants are known as important source in the search for new anti-cancer agents. Cytotoxicity-guided fractionation of leaves and fruits from Licania tomentosa Bench and leaves from Chrysobalanus icaco L. resulted in the isolation of betulinic, oleanolic and pomolic acids. These triterpenoids inhibited the growth and induced apoptosis of K562, an erythroleukemia cell line. Most importantly, they also inhibited the proliferation of Lucena 1, a vincristine-resistant derivative of K562 that displays several multidrug resistance (MDR) characteristics. Taken together, our findings emphasize the anti-tumor activity of these triterpenes on leukemia cell lines and call attention to their potential as anti MDR agents.
Fernandes
Janaina
J
Instituto de BiofIsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária, CEP, Ilha do Fundão 21949-900, R.J., Rio de Janeiro, Brazil.
Castilho
Rachel Oliveira
RO
da Costa
Mariana Rangel
MR
Wagner-Souza
Karen
K
Coelho Kaplan
Maria Auxiliadora
MA
Gattass
Cerli Rocha
CR
D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000473:pathology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000494:pharmacology
D010936:Plant Extracts; D014315:Triterpenes; D014750:Vincristine