title: Serum adenosine deaminase activity in women with pre-eclampsia.
abstract: The present study investigated serum adenosine deaminase (ADA) activity and the patterns of two ADA isoenzymes, ADA1 and ADA2, and to evaluate the possible role of cell-mediated immunity as causes of the changes in ADA activity in pre-eclampsia. We measured serum activities of total ADA, ADA1 and ADA2 in pre-eclampsia (n = 22) and normal pregnancy (n = 22). Peripheral blood monocyte counts and neopterin levels, reflecting the activation of the monocyte-macrophage cell system, were also measured. In pre-eclampsia, serum total ADA and ADA2 activities were significantly increased compared with normal pregnancy (p < 0.05), which were accompanied by increases in serum neopterin levels. These results suggest that increased total ADA activity reflects increases in ADA2 activity, which may be in part related to enhanced cell-mediated immunity during pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yoneyama
authors.forename: Rintaro
authors.initials: R
authors.lastname: Sawa
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Otsubo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miura
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishino
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kiyokawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Doi
authors.forename: Koichi
authors.initials: K
authors.lastname: Yoneyama
authors.forename: Hajime
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007958:Leukocyte Count; D019798:Neopterin / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D007527:Isoenzymes; D019798:Neopterin; D000243:Adenosine Deaminase