title: Efficient convergent synthesis of 1alpha,25-dihydroxyvitamin D3 and its analogues by Suzuki-Miyaura coupling.
abstract: [reaction: see text] 1alpha,25-Dihydroxyvitamin D(3) was synthesized by the Suzuki-Miyaura coupling of the A-ring intermediate 1, which was efficiently prepared from readily available 1,7-enyne 2, with the corresponding boronate compound of the C,D-ring portion. The method was applied to prepare des-C,D analogues of 1alpha,25-dihydroxyvitamin D(3).
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanazawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Koyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
authors.forename: Eiko
authors.initials: E
authors.lastname: Morishige
authors.forename: Sentaro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Fumie
authors.initials: F
authors.lastname: Sato
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001880:Boranes; D002117:Calcitriol / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D003500:Cyclization; D004811:Epichlorohydrin / Q000737:chemistry; D018020:Lithium Compounds
chemical_list: D000480:Alkynes; D001880:Boranes; D018020:Lithium Compounds; D004811:Epichlorohydrin; C021274:boron trifluoride; D002117:Calcitriol