2,5-Bis-(2-hydroxybenzoylamino)pentanoic acid, a salicylic acid-metabolite isolated from chicken: characterization and independent synthesis.
From excreta of chickens that had been treated with sodium salicylate, a new compound was detected and identified as a double conjugated ornithine metabolite. The structural assignment of this metabolite was further confirmed by an independent efficient 3-step synthesis from ornithine.
Hillaert
Ulrik
U
Ghent University, Faculty of Pharmaceutical Sciences, Laboratory for Medicinal Chemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.
Baert
Kris
K
Rozenski
Jef
J
Croubels
Siska
S
De Keukeleire
Denis
D
De Backer
Patrick
P
Van Calenbergh
Serge
S
D000215:Acylation; D000818:Animals; D001711:Biotransformation; D002645:Chickens / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010421:Pentanoic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D020156:Salicylic Acid / Q000097:blood*
C476318:2,5-bis-(2-hydroxybenzoylamino)pentanoic acid; D007202:Indicators and Reagents; D010421:Pentanoic Acids; D020156:Salicylic Acid