Thyroid-hormone-induced phosphate absorption in Aplysia californica gut is mediated through protein synthesis.
The mucosal membranes of Aplysia californica forgut epithelia contain a sodium-phosphate symporter that is stimulated by triiodothyronine. Actinomycin D, puromycin, or cycloheximide inhibited the triiodothyronine-stimulated phosphate absorption. It appears that thyroid hormone manifests its effects on phosphate absorption in the A. californica gut through protein synthesis.
Gerencser
George A
GA
Department of Physiology and Functional Genomics, College of Medicine, Box 100274 JHMHC, University of Florida, Gainesville, FL 32610, USA. gag@phys.med.ufl.edu
Cornette
Kuuleialoha M
KM
Zhang
Jianliang
J
D000818:Animals; D001048:Aplysia / Q000187:drug effects* / Q000378:metabolism; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000502:physiology; D012623:Seawater; D014284:Triiodothyronine / Q000494:pharmacology*
D010710:Phosphates; D011506:Proteins; D014284:Triiodothyronine