The analysis of pedigree GZ (Guangzhou). 1 with primary open angle glaucoma.
OBJECTIVE
To analyze the hereditary modality of primary open-angle glaucoma in China.


METHODS
The genetic form of Pedigree GZ. 1 was analyzed using Mandalian hereditary rules.


RESULTS
Pedigree GZ. 1 had following characteristics: 1) The pedigree had four generations, and there existed POAG patients in each generation; 2) Each patient had a parent with POAG. If the parents didn't suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1/2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients.


CONCLUSIONS
1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients.
Zhuo
Y
Y
Zhongshan Ophthalmic Center, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China.
Ge
J
J
Wang
M
M
Liu
H
H
Lin
M
M
D000293:Adolescent; D000328:Adult; D044466:Asian People; D005136:Eye Proteins / Q000235:genetics; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009154:Mutation; D010375:Pedigree
D005136:Eye Proteins; D006023:Glycoproteins