title: [Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].
abstract: OBJECTIVE
  To study the protective effect and mechanism of osthol on learning and memory impairment of mice with acute senile model induced by AlCl3.
  
  
  METHODS
  After s.c. AlCl3 60 mg.kg-1 for 7 d and i.p. osthol 15 and 7.5 mg.kg-1 for 12 d, using step-through test and step-down test, the effect of osthol on learning and memory was observed and the glutathione peroxidase (GSH-PX) activities in blood and superoxide dismutase (SOD) activities in plasma and cerebrum were measured.
  
  
  RESULTS
  Osthol 15 and 7.5 mg.kg-1 significantly improved the capability of memory and enhanced the activities of GSH-PX and SOD in AlCl3 treated mice.
  
  
  CONCLUSIONS
  Osthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl3. Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide.
authors.affiliation: Department of Pharmacology, Zhangjiakou Medical College, Zhangjiakou 075000, China.
authors.forename: Li-xia
authors.initials: LX
authors.lastname: Shen
authors.forename: Le-qun
authors.initials: LQ
authors.lastname: Jin
authors.forename: Dan-shen
authors.initials: DS
authors.lastname: Zhang
authors.forename: Gui-ping
authors.initials: GP
authors.lastname: Xue
mesh_terms: D000210:Acute-Phase Reaction; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002712:Chlorides / Q000494:pharmacology*; D031048:Cnidium / Q000737:chemistry; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D003374:Coumarins; D000077410:Aluminum Chloride; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C046627:osthol