[Clinical study of changes of urotensin II in patients with congestive heart failure].
OBJECTIVE
To investigate the changes of plasma urotensinII (UII) levels in patients with congestive heart failure (CHF) of different severities and their clinical implications.


METHODS
Plasma UII was determined by radioimmunoassay in 45 patients with CHF and 20 healthies control subjects. In all the subjects, the left ventricular fraction (LVEF) and the ratio of E/A were measured by echocardiography.


RESULTS
The plasma UII level was significantly lowered in CHF patients in comparison with that in control subjects (1.41+/-1.09 pg/ml vs 4.35+/-1.22 pg/ml, P=0.000). A significant correlation of plasma UII level with LVEF (r=0.540, P=0.000) and the E/A ratio was observed (r=0.539, P=0.000), and the severity of CHF was shown to be inversely correlated with plasma UII levels in the patients (r=-0.656, P=0.000), which was elevated after treatment.


CONCLUSIONS
UII might play a role in the pathophysiological process of CHF, and its plasma level may serve as an indicator of the severity of CHF.
Zhong
Ping
P
Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. zhongping1964@yahoo.com.cn
Li
Zhi-liang
ZL
Wu
Hong-chao
HC
Tang
Chao-shu
CS
Lu
Qing
Q
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014579:Urotensins / Q000097:blood*; D014667:Vasopressins / Q000097:blood
D014579:Urotensins; D014667:Vasopressins; C029677:urotensin II