[Study on the hypotensive effect of manascus].
The hypotensive effect of manascus was studied by using three well established rat models with hypertension: spontaneously hypertensive rat (SHR), renalvascular hypertensive rat (RHR, 2K1C) and DOCA-salt hypertensive rat. Manascus of 0.0, 0.4, 0.8, 1.2 g/kg BW (p.o.) were administrated daily to these animals for 3-4 weeks. Systolic blood pressure (SBP) and heart rate were measured once a week by using tail-cuff method. The hypotensive effect of manascus was observed in SHR and DOCA-salt hypertensive rats; and the effect was more potent in DOCA-salt hypertensive rat. Manascus showed less potential hypotensive effect in RHR.
Sun
M
M
Institute of Food Safety Control and Inspection, Beijing 100021, China.
Li
Y
Y
Yan
W
W
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D014908:Triticum
D000959:Antihypertensive Agents; D010936:Plant Extracts