title: Comparison of ropivacaine-fentanyl patient-controlled epidural analgesia with morphine intravenous patient-controlled analgesia for perioperative analgesia and recovery after open colon surgery.
abstract: OBJECTIVE
  To compare the effects of ropivacaine-fentanyl patient-controlled epidural analgesia (PCEA) with morphine intravenous (IV) patient-controlled analgesia (PCA).
  
  
  METHODS
  Prospective, randomized, multicenter trial.
  
  
  METHODS
  Five university-affiliated hospitals.
  
  
  METHODS
  41 patients undergoing colon surgery.
  
  
  METHODS
  Patients were randomized to receive either standardized combined epidural/general anesthesia followed by PCEA with ropivacaine 0.2% and fentanyl (2 microg/mL) or standardized general anesthesia followed by morphine IV PCA. All patients participated in a standardized postoperative clinical pathway.
  
  
  RESULTS
  Analgesia was assessed with visual analog scale (VAS) scores. Postoperative recovery was assessed by completion of prospectively defined discharge milestones and time until discharge. Statistical analyses included nonparametric and contingency table analyses. The PCEA group had better analgesia (> 50% reduction in pain scores, assessed both at rest and during a cough) for the first 3 days after surgery (p < 0.0,005). The PCEA group achieved discharge milestones approximately 36 hours faster (p < 0.002), but time until discharge was similar between groups.
  
  
  CONCLUSIONS
  Ropivacaine-fentanyl PCEA provides superior analgesia, reduced opioid requirement, and more rapid recovery after colon surgery.
authors.affiliation: Department of Anesthesiology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Steinberg
authors.forename: Spencer S
authors.initials: SS
authors.lastname: Liu
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Wu
authors.forename: David C
authors.initials: DC
authors.lastname: Mackey
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Grass
authors.forename: Kjell
authors.initials: K
authors.lastname: Ahlén
authors.forename: Lennart
authors.initials: L
authors.lastname: Jeppsson
mesh_terms: D000577:Amides; D015360:Analgesia, Epidural; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003106:Colon / Q000601:surgery*; D003371:Cough / Q000150:complications; D013505:Digestive System Surgical Procedures; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010351:Patient Discharge; D011229:Preanesthetic Medication; D011446:Prospective Studies; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009020:Morphine; D000077212:Ropivacaine