[Anti-lipoperoxidation of grape seed extracts in vitro].
The anti-lipoperoxidation of grape seed extracts (GSE) was observed by malondialdehyde (MDA) generated in liver and brain homogeneates spontaneously or induced by CCl4, H2O2, Fe(2+)-ascorbic acid. The exhaustion of glutathione (GSH) in liver homogenate initiated by Fe(2+)-ascorbic acid was also tested. Results showed that GSE significantly inhibited the generation of MDA in rat liver and brain homogenates both spontaneously formed or induced by CCl4, H2O2 and Fe(2+)-ascorbic acid with dose-effect relationships. GSE could also reduce the exhaustion of GSH levels in mice liver. The study indicated that GSE is effective on the inhibition of lipid peroxide and on the protection of liver from injury caused by lipid peroxidation.
Guo
Ying
Y
School of Public, Jilin University, Changchun 130021, China.
Cai
Xiucheng
X
Chen
Qiuli
Q
Li
Wei
W
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
D000975:Antioxidants; D010936:Plant Extracts