title: Sordaricin antifungal agents.
abstract: Compounds based on sordaricin were prepared via organometallic addition onto a fully protected sordaricin aldehyde. The fungal growth inhibition profiles for these compounds were established and the results are presented here. The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement products upon oxidation. These compounds were evaluated as agents to inhibit fungal growth.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 100, boul. de l'Industrie, Candiac, Québec, Canada J5R 1J1. claude.quesnelle@bms.com
authors.forename: Claude A
authors.initials: CA
authors.lastname: Quesnelle
authors.forename: Patrice
authors.initials: P
authors.lastname: Gill
authors.forename: Marco
authors.initials: M
authors.lastname: Dodier
authors.forename: Denis
authors.initials: D
authors.lastname: St  Laurent
authors.forename: Michael
authors.initials: M
authors.lastname: Serrano-Wu
authors.forename: Anne
authors.initials: A
authors.lastname: Marinier
authors.forename: Alain
authors.initials: A
authors.lastname: Martel
authors.forename: Charles E
authors.initials: CE
authors.lastname: Mazzucco
authors.forename: Terry M
authors.initials: TM
authors.lastname: Stickle
authors.forename: John F
authors.initials: JF
authors.lastname: Barrett
authors.forename: Dolatrai M
authors.initials: DM
authors.lastname: Vyas
authors.forename: Balu N
authors.initials: BN
authors.lastname: Balasubramanian
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000478:Alkylation; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes; D005658:Fungi / Q000187:drug effects; D006868:Hydrolysis; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D000935:Antifungal Agents; D004224:Diterpenes; D007202:Indicators and Reagents; C116705:sordaricin