title: A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase.
abstract: A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2'-hydroxy-4'-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.
authors.affiliation: PanTherix Ltd., Todd Campus, West of Scotland Science Park, Glasgow G20 0XA, Scotland, UK. michael.thomas@panterix.co.uk
authors.forename: Michael G
authors.initials: MG
authors.lastname: Thomas
authors.forename: Chris
authors.initials: C
authors.lastname: Lawson
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Allanson
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Leslie
authors.forename: Joanna R
authors.initials: JR
authors.lastname: Bottomley
authors.forename: Andrew
authors.initials: A
authors.lastname: McBride
authors.forename: Oyinkan A
authors.initials: OA
authors.lastname: Olusanya
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D003001:Cloning, Molecular; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019761:Phosphorus-Oxygen Lyases / Q000037:antagonists & inhibitors*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012765:Shikimic Acid / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D001593:Benzyl Compounds; D004791:Enzyme Inhibitors; D012765:Shikimic Acid; C019895:chorismate synthase; D019761:Phosphorus-Oxygen Lyases