The subventricular zone: new molecular and cellular developments.
The subventricular zone (SVZ), which lines the lateral walls of the lateral ventricle, persists as a neurogenic zone into adulthood and functions as the largest site of neurogenesis in the adult brain. In recent years, with the acceptance of the concept of postembryonic mammalian neurogenesis, neurogenesis in the adult SVZ has been an area of active research. With the rapid accumulation of new information on the SVZ, some of which is contradictory, summarizing existing knowledge on the SVZ and outlining future research directions in this area become important. In this review, we will cover recent molecular and cellular investigations that characterize the SVZ niche, SVZ neurogenesis, and SVZ cell migration within the adult brain.
Conover
J C
JC
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. jcc@jax.org
Allen
R L
RL
D000818:Animals; D002352:Carrier Proteins; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D020547:Lateral Ventricles / Q000166:cytology* / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*; D000099176:Noggin Protein
D002352:Carrier Proteins; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; D000099176:Noggin Protein