title: Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia.
abstract: OBJECTIVE
  The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated.
  
  
  METHODS
  Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined.
  
  
  RESULTS
  Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level.
  
  
  CONCLUSIONS
  A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.
authors.affiliation: Health and Medical Center, Okayama University, Okayama, Japan. oguogu@cc.okayama-u.ac.jp
authors.forename: Tosjio
authors.initials: T
authors.lastname: Ogura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
authors.forename: Mamoru
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Katsunori
authors.initials: K
authors.lastname: Oe
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Matsuura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tobe
authors.forename: Yukari
authors.initials: Y
authors.lastname: Mimura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kishida
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
authors.forename: Masahisa
authors.initials: M
authors.lastname: Hirakawa
mesh_terms: D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins / Q000652:urine*; D001127:Arginine Vasopressin / Q000097:blood*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D013997:Time Factors
chemical_list: C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D010455:Peptides; D001127:Arginine Vasopressin; D053607:Adrenomedullin; D003404:Creatinine