title: Comparative genome analysis of the primary sex-determining locus in salmonid fishes.
abstract: We compared the Y-chromosome linkage maps for four salmonid species (Arctic charr, Salvelinus alpinus; Atlantic salmon, Salmo salar; brown trout, Salmo trutta; and rainbow trout, Oncorhynchus mykiss) and a putative Y-linked marker from lake trout (Salvelinus namaycush). These species represent the three major genera within the subfamily Salmoninae of the Salmonidae. The data clearly demonstrate that different Y-chromosomes have evolved in each of the species. Arrangements of markers proximal to the sex-determining locus are preserved on homologous, but different, autosomal linkage groups across the four species studied in detail. This indicates that a small region of DNA has been involved in the rearrangement of the sex-determining region. Placement of the sex-determining region appears telomeric in brown trout, Atlantic salmon, and Arctic charr, whereas an intercalary location for SEX may exist in rainbow trout. Three hypotheses are proposed to account for the relocation: translocation of a small chromosome arm; transposition of the sex-determining gene; or differential activation of a primary sex-determining gene region among the species.
authors.affiliation: Department of Zoology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Woram
authors.forename: Karim
authors.initials: K
authors.lastname: Gharbi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Bjorn
authors.initials: B
authors.lastname: Hoyheim
authors.forename: Lars-Erik
authors.initials: LE
authors.lastname: Holm
authors.forename: Kerry
authors.initials: K
authors.lastname: Naish
authors.forename: Colin
authors.initials: C
authors.lastname: McGowan
authors.forename: Moira M
authors.initials: MM
authors.lastname: Ferguson
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Phillips
authors.forename: Jake
authors.initials: J
authors.lastname: Stein
authors.forename: René
authors.initials: R
authors.lastname: Guyomard
authors.forename: Margaret
authors.initials: M
authors.lastname: Cairney
authors.forename: John B
authors.initials: JB
authors.lastname: Taggart
authors.forename: Richard
authors.initials: R
authors.lastname: Powell
authors.forename: William
authors.initials: W
authors.lastname: Davidson
authors.forename: Roy G
authors.initials: RG
authors.lastname: Danzmann
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D015321:Gene Rearrangement / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D016678:Genome; D018895:Microsatellite Repeats / Q000235:genetics; D017686:Oncorhynchus mykiss / Q000235:genetics; D020317:Salmo salar / Q000235:genetics; D012474:Salmon / Q000235:genetics; D012487:Salmonidae / Q000235:genetics*; D019849:Sex Determination Processes; D014337:Trout / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics
chemical_list: D005819:Genetic Markers