A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia.
In this case report, we present a pediatric case of lymphomatoid granulomatosis (LG) with onset just after the completion of chemotherapy for childhood acute myeloid leukemia (AML). After the completion of maintenance therapy, the patient was admitted to our clinic with a complaint of cough. Radiologic examinations revealed nodular lesions in lungs, liver, and kidney. His bone marrow was in remission. The histopathologic examination of the open lung biopsy was consistent with LG. He received only one cycle of cyclophosphamide and high-dose methyl prednisolone treatment and continued to receive interferon (IFN) alpha-2b therapy for 18 months. This treatment regimen resulted in an excellent response. In conclusion, LG may occur after the treatment of pediatric AML as a rare complication and IFN alpha-2b may be an effective treatment choice in these patients.
Oren
Hale
H
Department of Pediatric Hematology, Dokuz Eylül University, Faculty of Medicine, Izmir, Turkey. hale.oren@dev.edu.tr
Irken
Gülersu
G
Kargi
Aydanur
A
Ozkal
Sermin
S
Uçar
Canan
C
Gülen
Hüseyin
H
Duman
Murat
M
Atabay
Berna
B
Yilmaz
Sebnem
S
Kovanlikaya
Arzu
A
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011994:Recombinant Proteins; D016896:Treatment Outcome
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D003520:Cyclophosphamide; D008775:Methylprednisolone