[Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer].
To explore the correlation between fumonisins and human esophageal cancer (HEC), the estimated fumonisin intake and the urinary sphinganine/sphingosine (Sa/So) ratio were investigated in the population with a high HEC incidence in the suburb of Hebi city, Henan province. Fumonisins were detected from 95 percent of corn samples in the endemic area, and the concentration of total fumonisins (fumonisin B1, B2 and B3) was in the range from 7.2 to 726.8 micrograms/kg. The estimated daily intake of fumonisins was in the range from 0 to 4.84 micrograms/(kg.d) in males, while from 0 to 4.04 micrograms/(kg.d) in females. Compared with the population in a low HEC incidence area, Suixian county, Henan province, the urinary Sa/So ratio of males in the endemic area was statistically significant higher, although no difference was observed in females. The results indicated that fumonisin might be one of the risk factors for the occurrence of HEC.
Qiu
M
M
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Liu
X
X
Wang
Y
Y
Zhang
C
C
D000328:Adult; D002523:Edible Grain / Q000382:microbiology*; D004938:Esophageal Neoplasms / Q000209:etiology*; D005260:Female; D005506:Food Contamination; D037341:Fumonisins / Q000008:administration & dosage*; D005670:Fusarium / Q000378:metabolism; D006801:Humans; D008297:Male; D009183:Mycotoxins / Q000008:administration & dosage; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000652:urine*
D037341:Fumonisins; D009183:Mycotoxins; C056934:fumonisin B2; C056933:fumonisin B1; D013110:Sphingosine; C005682:safingol