title: Evaluation of vinylsulfamides as sulfhydryl selective alkylation reagents in protein modification.
abstract: The preparation of several model vinylsulfamides is described. Their excellent selective reactivity towards sulfhydryl group with regards to amino group has been demonstrated by the kinetics study between a model vinylsulfamide and cysteine or lysine at different pHs.
authors.affiliation: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA. minli88@att.net
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Robert S
authors.initials: RS
authors.lastname: Wu
authors.forename: Jane S C
authors.initials: JS
authors.lastname: Tsai
authors.forename: Salvatore J
authors.initials: SJ
authors.lastname: Salamone
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007700:Kinetics; D011506:Proteins / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013439:Sulfhydryl Reagents / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000477:Alkylating Agents; D005030:Ethylenes; D007202:Indicators and Reagents; D011506:Proteins; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D013449:Sulfonamides