Inhibitors of lysine biosynthesis as antibacterial agents.
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.
Hutton
Craig A
CA
School of Chemistry, The University of Sydney, NSW 2006, Australia. c.hutton@chem.usyd.edu.au
Southwood
Timothy J
TJ
Turner
Jennifer J
JJ
D000217:Acyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000581:Amidohydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000591:Amino Acid Isomerases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001223:Aspartate-Semialdehyde Dehydrogenase / Q000037:antagonists & inhibitors; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D003960:Diaminopimelic Acid / Q000031:analogs & derivatives; D050746:Dihydrodipicolinate Reductase; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006836:Hydro-Lyases / Q000037:antagonists & inhibitors / Q000378:metabolism; D008239:Lysine / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D044925:Oxidoreductases Acting on CH-CH Group Donors; D013329:Structure-Activity Relationship; D051277:Succinyldiaminopimelate Transaminase; D000637:Transaminases / Q000037:antagonists & inhibitors / Q000378:metabolism
D000217:Acyltransferases; D000581:Amidohydrolases; D000591:Amino Acid Isomerases; D000594:Amino Acid Oxidoreductases; D000900:Anti-Bacterial Agents; D001223:Aspartate-Semialdehyde Dehydrogenase; D001426:Bacterial Proteins; D002262:Carboxy-Lyases; D003960:Diaminopimelic Acid; D050746:Dihydrodipicolinate Reductase; D004791:Enzyme Inhibitors; D006836:Hydro-Lyases; D008239:Lysine; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D051277:Succinyldiaminopimelate Transaminase; D000637:Transaminases; C020032:diaminopimelate dehydrogenase; C040777:succinyl-CoA-tetrahydrodipicolinate N-succinyltransferase; C054685:N-succinyl-l,l-diaminopimelic acid desuccinylase; C079912:LysA protein, Bacteria; C020031:diaminopimelic acid decarboxylase; C020040:4-hydroxy-tetrahydrodipicolinate synthase; C042032:diaminopimelate epimerase