title: [The study of the nasal airway reactivity in specific nasal provocation test].
abstract: OBJECTIVE
  To explore efficient evaluation method for specific nasal provocation test(SNPT) and to observe the pathogenic process and patho-physiological changes of allergic rhinitis.
  
  
  METHODS
  30 patients with perennial allergic rhinitis(patients group) and 14 normal adults(controls group) were challenged unilaterally with the Coca's solution and/or the solution for allergen extracts. The nasal resistance variations in all subjects were monitored with active anterior rhinomanometry and the nasal symptoms were observed.
  
  
  RESULTS
  The symptoms of nasal stiffness, sneezing and rhinorrhea appeared in most patients between 0.5 and 3 minutes after provocation. The ratio of continual sneezes above 5 in patients group(83.3%) was significantly higher than in controls group (21.4%) (P < 0.01). The increased ratio of total nasal resistance and unilaterally-challenged nasal resistance were significantly higher in patients group than in controls group (P < 0.05) and no difference between coca's solution in patients group and controls group.
  
  
  CONCLUSIONS
  Positive SNPT was indicated if obvious nasal symptoms appeared and the unilaterally-challenged nasal resistance increased 100% as well as the total nasal resistance increased 40% after SNPT.
authors.affiliation: Department of ENT, Union Hospital, Tongji Medical University, Wuhan 430022.
authors.forename: J X
authors.initials: JX
authors.lastname: Yue
authors.forename: H F
authors.initials: HF
authors.lastname: Tan
authors.forename: X Z
authors.initials: XZ
authors.lastname: Huang
authors.forename: J S
authors.initials: JS
authors.lastname: Xiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000503:physiopathology*; D025363:Rhinomanometry