title: [Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].
abstract: OBJECTIVE
  To study the effect of tanshinone IIA on liver fibrosis in rats induced by CCl4.
  
  
  METHODS
  Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.
  
  
  RESULTS
  Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.
  
  
  CONCLUSIONS
  Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.
authors.affiliation: First Military Medical University, Guangzhou 510515.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Liu
authors.forename: Houchang
authors.initials: H
authors.lastname: Chen
authors.forename: Yiping
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D045784:Abietanes; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism / Q000473:pathology*; D010616:Phenanthrenes / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D045784:Abietanes; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C021751:tanshinone