Small, dense low-density lipoprotein: risk or myth?
Based on the particle diameter of the major subpopulation of low-density lipoprotein (LDL) in plasma, an individual may be classified either as having phenotype A (desirable phenotype; large, buoyant LDL) or phenotype B (high risk; small, dense LDL). This article reviews the clinical significance of LDL particle diameter determination and proposes a strategy for incorporating this information in the new guidelines of the National Cholesterol Education Program's Adult Treatment Panel III.
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Emory Lipid Research Laboratory, Emory University School of Medicine, Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Mail Code 151, Decatur, GA 30033, USA. ale@emory.edu
D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000009:adverse effects* / Q000502:physiology* / Q000648:ultrastructure; D012307:Risk Factors
D008077:Lipoproteins, LDL