Postpartum maternal levels of hemoglobin A1c and cord C-peptide in macrosomic infants of non-diabetic mothers.
OBJECTIVE
This study was designed to test the hypothesis that macrosomia in infants born to non-diabetic mothers is associated with an increased incidence of hyperinsulinemia and normal maternal glucose regulation in late pregnancy.


METHODS
Twenty mothers and their macrosomic infants were chosen as the study group, and 20 mothers with their appropriate-for-gestational-age infants were chosen as the control group.


RESULTS
No difference in postpartum mean hemoglobin A1c levels was observed between the mothers of macrosomic infants and those of control infants. Cord plasma C-peptide levels were significantly higher in macrosomic than in control infants.


CONCLUSIONS
This study revealed that macrosomic infants of non-diabetic mothers were significantly more likely to have hyperinsulinemia than were normal-sized infants, and this hyperinsulinemia was not caused by dysregulation in glucose metabolism.
Akin
M
M
Haydarpasa Numune Training and Research Hospital, Turkey.
Ceran
O
O
Atay
E
E
Atay
Z
Z
Akin
F
F
Akturk
Z
Z
D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000097:blood* / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007231:Infant, Newborn; D008297:Male; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000378:metabolism
D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin