title: Translocation (11;19)(q23;p13.3) associated with a novel t(5;16) (q13;q22) in a patient with acute myelocytic leukemia.
abstract: A novel association of t(11;19)(q23;p13) and t(5;16)(q13;q22) was detected by G-banding and spectral karyotyping studies in an 18-year-old patient. While balanced t(11;19) has been often described in acute myelocytic leukemia (AML) French-American-British Cooperative Group subtypes M4 and M5, this patient was diagnosed with the variant AML-M4 with eosinophilia (AML-M4Eo), which is associated with abnormalities in 16q22 and has good prognosis. However, the patient relapsed after allogeneic transplant and died within 2 years of diagnosis, which suggests that the association of these two translocations correlates with a poor prognosis. This report expands the molecular basis of the variability in clinical outcomes and adds the novel t(5;16)(q13;q22) to the spectrum of chromosome 16q22 abnormalities in AML.
authors.affiliation: Department of Biology, IBILCE-UNESP, São José do Rio Preto, São Paulo, Brazil.
authors.forename: Cristina Benitez
authors.initials: CB
authors.lastname: Vendrame-Goloni
authors.forename: Marileila
authors.initials: M
authors.lastname: Varella-Garcia
authors.forename: Andréa Borduchi
authors.initials: AB
authors.lastname: Carvalho-Salles
authors.forename: Milton Artur
authors.initials: MA
authors.lastname: Ruiz
authors.forename: Otávio Ricci
authors.initials: OR
authors.lastname: Júnior
authors.forename: Agnes Cristina
authors.initials: AC
authors.lastname: Fett-Conte
mesh_terms: D000293:Adolescent; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D032681:Spectral Karyotyping; D014178:Translocation, Genetic / Q000235:genetics*