title: Duration of warfarin sodium therapy prior to electrical cardioversion of atrial fibrillation.
abstract: OBJECTIVE
  To evaluate the duration of anticoagulation treatment with warfarin sodium before elective DC-cardioversion and to identify clinical variables predicting short-term versus long-term waiting times.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Patients with a known start date for warfarin sodium, a known duration of atrial fibrillation (AF) and who underwent DC-cardioversion were included.
  
  
  METHODS
  Duration of treatment with warfarin sodium prior to DC-cardioversion.
  
  
  METHODS
  The hospital records of 288 consecutive patients with AF scheduled for elective cardioversion at two hospitals in Stockholm were reviewed. Only patients with a known start date for warfarin sodium and known duration of AF were included in the study.
  
  
  RESULTS
  The median age was 70 (26-85) years and the duration of AF at time of cardioversion were 18 weeks (5-273) weeks. The median treatment duration prior to cardioversion with warfarin sodium was 12 weeks. Sinus rhythm was established in 224 (78%) patients of which 90 (40%) remained in sinus rhythm 1 month after cardioversion. In multivariate analysis, the only independent predictor of short waiting times for cardioversion (8 vs. 15 weeks) was if a cardiologist instituted the treatment with warfarin sodium (P < 0.001, 95% CI 5.0-9.0).
  
  
  CONCLUSIONS
  The average waiting time from start of warfarin sodium treatment to elective cardioversion exceeds by far the recommended 3-4 weeks on therapeutic international normalized ratio (INR). In order to minimize the time period until cardioversion significant changes in the out-of-hospital care logistics has to be undertaken.
authors.affiliation: Department of Cardiology, South Hospital, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ryman
authors.forename: M
authors.initials: M
authors.lastname: Frick
authors.forename: V
authors.initials: V
authors.lastname: Frykman
authors.forename: M
authors.initials: M
authors.lastname: Rosenqvist
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000628:therapy*; D004554:Electric Countershock / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014859:Warfarin