title: [Effect of combination of Chinese herbal drugs on clinical bioavailability of ferulic acid in serum].
abstract: OBJECTIVE
  To observe the effect of combination of Chinese herbal drugs on bioavailability of Ligusticum walichii (LW) derived ferulic acid (FA) in serum.
  
  
  METHODS
  Healthy volunteers were given LW decoction (1 g/kg), LW combined with Paeonia veitchii (PV, 1:1) decoction (2 g/kg) and Coronary Heart No. 2 (CH-II, 3 g/kg, containing LW 0.5 g/kg) once respectively. The serum FA concentration-time (c-t) curve was performed by HPLC using the method established by the authors, and the area under that curve (AUC) was calculated and compared.
  
  
  RESULTS
  The FA c-t curve in the three groups was double peak curve. As compared with the AUC in subjects who were administered LW decoction, the AUC in those taken LW + PV decoction was lower [(15734.88 +/- 7737.97) ng/(min.ml) vs (5717.92 +/- 6124.63) ng/(min.ml)], P < 0.05), while that in those taken CH-II was relatively higher [(8072.00 +/- 4424.31) ng/(min.ml), P > 0.05)].
  
  
  CONCLUSIONS
  Combination of LW and PV could significantly lower the bioavailability of FA, but when LW was added in CH-II, the FA bioavailability was not affected.
authors.affiliation: Department of Clinical Pharmacology of Chinese Drugs, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Ren
authors.forename: K J
authors.initials: KJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D029596:Paeonia / Q000737:chemistry
chemical_list: D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C004999:ferulic acid