[Clinical observation of compound salvia injection in treating mid-severe infantile hypoxic-ischemic encephalopathy].
OBJECTIVE
To observe the changes of endothelin-1 (ET-1), nitrogen oxide (NO) and creatine phosphokinase BB isozyme (CK-BB) in blood and cerebrospinal fluid (CSF) in patients of infantile hypoxic-ishemic encephalopathy (HIE), and explore the efficacy of compound Salvia injection (CSI) in treating mid-severe HIE.


METHODS
Sixty mid-severe infantile HIE patients were divided randomly into the treated and the control group. To the treated group CSI was added on the basis of conventional treatment, and to the control group the conventional treatment was given alone. The blood and CSF content of ET-1, NO and CK-BB at acute and convalescent stage in the two groups were determined and the therapeutic effects were compared between the two groups.


RESULTS
The markedly effective rate and effective rate of the treated group was 80.0% and 93.3% respectively, while that of the control group was 66.7% and 83.3% respectively, the therapeutic effect in the treated group were obviously superior to that in the control group, the difference was significant (P < 0.05).


CONCLUSIONS
ET-1, NO and CK-BB participated the pathological process of HIE. CSI was markedly effective in treating mid and severe HIE infants.
Jiang
F X
FX
Dongguan Municipal Donghua Hospital, Guangdon 523000.
Wang
S J
SJ
Zhong
L
L
D003402:Creatine Kinase / Q000097:blood; D052276:Creatine Kinase, BB Form; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood / Q000188:drug therapy*; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D008517:Phytotherapy; D010936:Plant Extracts; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D007527:Isoenzymes; D010936:Plant Extracts; D009569:Nitric Oxide; D003402:Creatine Kinase; D052276:Creatine Kinase, BB Form