title: Chromosome analysis in 31 cases of benign and malignant breast tumors: a study in Brazil.
abstract: Cultures of 31 breast tumors, being 20 carcinomas and 11 benign lesions, were cytogenetically analysed. Clonal chromosome aberrations were detected in 16 carcinomas and in 4 benign lesions. Nine carcinomas and 2 benign lesions had multiple cytogenetically unrelated and related clones, whereas a single abnormal clone was observed in 7 carcinomas and in 2 benign lesions. Polyploid clones were found in 7 carcinomas and in 2 benign lesions. The presence of clonal chromosome aberrations and polyploid cells was not associated with the clinicopathologic parameters tested. Carcinomas had more clonal changes than benign lesions (p = 0.031), showing that cytogenetic features are of diagnostic value and that different chromosome anomalies might have different pathogenetic and prognostic significance.
authors.affiliation: Department of Genetics, Federal University of Rio Grande do Sul, Brazil. marare@catolico.com.br
authors.forename: Mara Regina Netto
authors.initials: MR
authors.lastname: Benetti
authors.forename: Rejane Gus
authors.initials: RG
authors.lastname: Kessler
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Bittelbrunn
authors.forename: Bárbara
authors.initials: B
authors.lastname: Frantz
authors.forename: Jorge Villanova
authors.initials: JV
authors.lastname: Biazus
authors.forename: Roberto
authors.initials: R
authors.lastname: Giugliani
mesh_terms: D000328:Adult; D001938:Brazil; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011003:Ploidies