title: [Effect of natrahagin, a Chinese cobra venom proteinase on hemorrheology in rat].
abstract: The effects of natrahagin, a Chinese cobra venom proteinase on hemorrheology and plasma fibrinogen level in rat was investigated. The results showed that intravenous injection of natrahagin (0.025-0.1 mg/kg) dose-dependently decreased the whole blood viscosity and the plasma viscosity (P < 0.05 or P < 0.01) in rat, but caused no significant effect on hematocrit (P > 0.05). Natrahagin also decreased the plasma fibrinogen level (P < 0.05 or P < 0.01) of rat in a dose-dependent manner at these doses.
authors.affiliation: Pharmaceutical Department of Nanfang Hospital, the First Military Medical University, Guangzhou 510515.
authors.forename: D
authors.initials: D
authors.lastname: Guo
authors.forename: L
authors.initials: L
authors.lastname: Hou
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.forename: N
authors.initials: N
authors.lastname: Chen
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000737:chemistry; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D008297:Male; D008666:Metalloendopeptidases / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004546:Elapid Venoms; D005343:Fibrinolytic Agents; D005340:Fibrinogen; D008666:Metalloendopeptidases; C424242:natrahagin