Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane).
The new water soluble ruthenium complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane) were synthesised and characterised. Their evaluation as regioselective catalysts for hydrogenation of unsaturated ketones in aqueous biphasic conditions and as cytotoxic agents towards the TS/A adenocarcinoma cell line is briefly presented.
Akbayeva
Dina N
DN
Istituto di Chimica dei Composti Organometallici, ICCOM-CNR, Via Jacopo Nardi 39, 50132 Firenze, Italy.
Gonsalvi
Luca
L
Oberhauser
Werner
W
Peruzzini
Maurizio
M
Vizza
Francesco
F
Brüggeller
Peter
P
Romerosa
Antonio
A
Sava
Gianni
G
Bergamo
Alberta
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D002455:Cell Division / Q000187:drug effects; D006865:Hydrogenation; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012428:Ruthenium