title: [Mechanism study of electrothrombosis by copper needle].
abstract: OBJECTIVE
  To investigate the mechanism of electrothrombosis by copper needle, in order to supply the referential data for clinical treatment of vessel deformity.
  
  
  METHODS
  The mechanism and condition of thrombus formation by copper needle were studied in vivo and in vitro using electrophysics, atom absorption spectrophtometry, histological, and histochemical methods.
  
  
  RESULTS
  Great deal of copper ion was dissociated, and agglutination of red blood cells(RBC) in blood could be observed in vitro after the current applied by copper needles. Formation of stable thrombus was related to voltage and time of application of electric current.
  
  
  CONCLUSIONS
  Dissociation of copper ion and agglutination of RBC are the basic principle of electrothrombosis with copper needle. A 4V direct current and 17.5 minutes are the safe and effective conditions for thrombus formation in the blood vessels.
authors.affiliation: Department of Plastic Surgery, Third Hospital of Peking University, Beijing, P. R. China 100083.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: T L
authors.initials: TL
authors.lastname: Jia
authors.forename: R S
authors.initials: RS
authors.lastname: Qin
mesh_terms: D000818:Animals; D003300:Copper; D004599:Electric Stimulation Therapy / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods*; D004903:Erythrocyte Aggregation; D066298:In Vitro Techniques; D007477:Ions; D009339:Needles; D051381:Rats; D013997:Time Factors
chemical_list: D007477:Ions; D003300:Copper