[Comparative study on effect of recipe for activating blood circulation and replenishing Qi on left ventricular remodeling in rats with left heart failure after myocardial infarction].
OBJECTIVE
Comparative study to the effect of Chinese herbal medicine on left ventricular remodeling in rats with left heart failure after myocardial infarction (MI).


METHODS
Rat's model of left heart failure after myocardial infarction was treated with injection for activating blood circulation (ABCI, consisted of R. Salviae miltiorrhizea; Rh. Ligusticum wallichii and F1. Carthamus tinctorius) and injection for replenishing Qi (RQI, consisted of R. Codonopsis Pilosulae and R. Astragalus membranaceus) respectively. The effect of treatment were evaluated by observing and comparing the changes of heart morphological structure, collagen element, heart weight/body weight ratio (HW/BW), left intraventricular area (LVA), ratio of ventricular wall thinning in MI area and myocardial nuclei number (MNN) per square area.


RESULTS
In comparison with the model group, the reduction of collagen tissue around myocardial cells in living area of MI, HW/BW and LVA of ABCI and RQI group were lower, and MNN per square area was higher significantly (all P < 0.05).


CONCLUSIONS
Both ABCI and RQI, though without positive myodynamia, showed certain inhibitory effect of left ventricular remodeling in rats with left heart failure after MI.
Wang
Zhen-tao
ZT
Dongzhimen Hospital, Beijing University of TCM, Beijing 100700.
Wang
Shuo-ren
SR
Zhao
Ming-jing
MJ
D000818:Animals; D027885:Astragalus propinquus; D002303:Cardiac Output, Low / Q000473:pathology* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D008517:Phytotherapy; D019413:Qi; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000187:drug effects*
D004365:Drugs, Chinese Herbal