title: Early events in protein folding.
abstract: Recent advances have significantly increased the time and spectroscopic resolution of protein folding experiments. We can now study the timescale and nature of polypeptide collapse, and how this correlates with secondary and tertiary structure formation. Studies on ultrafast folding proteins and peptides provide experimental benchmarks on a timescale that overlaps directly with that of molecular dynamics simulations. This makes possible direct tests of both simulations and current models of protein folding.
authors.affiliation: MRC Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 2QH, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Ferguson
authors.forename: Alan R
authors.initials: AR
authors.lastname: Fersht
mesh_terms: D008958:Models, Molecular; D009038:Motion; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins