Inhibition of 5alpha-reductase activity by diarylheptanoids from Alpinia officinarum.
The acetone extract from the rhizomes of Alpinia officinarum was evaluated for activity against 5alpha-reductase which had been prepared from rat prostate. The fraction responsible for the inhibition of the enzyme was purified, analyzed, and the active constituents were identified as four diarylheptanoids, 1,7-diphenylhept-4-en-3-one, dihydroyashabushiketol (1,7-diphenyl-5-hydroxy-3-heptanone), 5-hydroxy-7-(4"-hydroxy-3"-methoxyphenyl)-1-phenyl-3-heptanone and 5-hydroxy-7-(4"-hydroxyphenyl)-1-phenyl-3-heptanone.
Kim
Yong-ung
YU
Son
Hyun Kyong
HK
Song
Hye Kyoung
HK
Ahn
Mi-Jeong
MJ
Lee
Sang Sup
SS
Lee
Seung Ki
SK
D058891:5-alpha Reductase Inhibitors; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D036381:Diarylheptanoids / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D011467:Prostate / Q000201:enzymology; D051381:Rats
D058891:5-alpha Reductase Inhibitors; D036381:Diarylheptanoids; D004791:Enzyme Inhibitors