[Expression of CD44s and CD44v6 in laryngeal squamous cell carcinoma and their significance].
OBJECTIVE
To study the correlation between the expression of CD44s, CD44v6 and the clinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so as to analyze the role of them in occurrence and progression of LSCC.


METHODS
Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 cases of adjacent normal tissues was inspected with immunohistochemical SP method.


RESULTS
The expression of CD44s increased significantly in lymphnode metastasis group (94.4%) and stage III-IV group (96.2%), but decreased in non-lymphnode metastasis group (67.9%) and stage I-II group (55.0%). The expression of CD44v6 was lower (21.7%), which wasn't associated with any clinicopathological characters.


CONCLUSIONS
The role of CD44 and CD44v6 in carcinoma maybe dependent on the species, type of carcinoma, and the expression of CD44s may be a biologic marker to evaluate metastasis of LSCC.
Wang
S L
SL
Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060.
Yang
Q
Q
Xiao
B K
BK
Jiang
Y S
YS
Chen
E H
EH
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors