title: Autoimmune neutropenia associated with multiple sclerosis.
abstract: A 53-year-old Japanese man with multiple sclerosis developed autoimmune neutropenia. The neutrophil count was consistently less than 0.2 x 10(9)/l, irrespective of the disease activity of multiple sclerosis or the administration of immunosuppressive agents or granulocyte colony-stimulating factor. After high-dose gamma-globulin therapy was started, temporary increases in the neutrophil count were observed. Despite a wide spectrum of clinical manifestations in multiple sclerosis, autoimmune neutropenia has never been reported previously.
authors.affiliation: Department of Internal Medicine II, Okayama University Medical School, Okayama.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kozuka
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Kaneda
authors.forename: Katsuto
authors.initials: K
authors.lastname: Takenaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Manabe
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hirata
authors.forename: Shigenori
authors.initials: S
authors.lastname: Okuma
authors.forename: Hironobu
authors.initials: H
authors.lastname: Toki
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000628:therapy; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007937:Leukapheresis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000628:therapy; D009503:Neutropenia / Q000097:blood / Q000150:complications* / Q000628:therapy; D009504:Neutrophils; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D007166:Immunosuppressive Agents; D005719:gamma-Globulins; D016572:Cyclosporine