title: Mal de Meleda: a new geographical localization in Anatolia.
abstract: BACKGROUND
  Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma first described on the Dalmatian island of Meleda. MDM has been observed in many other countries so that the origin of the MDM gene may be elsewhere than in Meleda.
  
  
  OBJECTIVE
  After identification of the first MDM patient during a medical visit, a study was planned to reveal other families with MDM in the Köprüçay region in Anatolia.
  
  
  METHODS
  The patient was interviewed with a questionnaire including a pedigree drawing. All the subsequent cases reported to be of MDM were visited for clinical examination and pedigree drawings.
  
  
  RESULTS
  Thirty-nine patients, 8 families and 2 additional cases with MDM were identified in a 50-km(2) mountainous region in Köprüçay canyon in Anatolia. The prevalent clinical features were nail involvement (80%), 'glove-and-sock' distribution of the keratoderma (60%), edema on the hands/feet (60%), conical tapering of the fingertips (60%) and hyperhidrosis on the palms and soles (50%).
  
  
  CONCLUSIONS
  To our knowledge, this is the largest series reported. The relationship between the patients in Meleda and those in Anatolia awaits discovery by further researches that will be carried out with the collaboration of dermatology, genetics and medical history departments.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. sergin@pamukkale.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Ergin
authors.forename: B Sanli
authors.initials: BS
authors.lastname: Erdogan
authors.forename: S
authors.initials: S
authors.lastname: Aktan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D006801:Humans; D007223:Infant; D007645:Keratoderma, Palmoplantar / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014421:Turkey / Q000453:epidemiology