title: Effects of DDAVP administrated subcutaneously in dogs with aspirin-induced platelet dysfunction and hemostatic impairment due to chronic liver diseases.
abstract: To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 microg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 +/- 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.
authors.affiliation: Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Sakai
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Watari
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Miura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Maruyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koie
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaya
authors.forename: Akira
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects; D001791:Blood Platelet Disorders / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005169:Factor VIII; D006487:Hemostasis / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008107:Liver Diseases / Q000150:complications* / Q000662:veterinary*
chemical_list: D005169:Factor VIII; D003894:Deamino Arginine Vasopressin; D001241:Aspirin