Neurologic aspects of HIV infection in infants and children: therapeutic approaches and outcome.
Central nervous system (CNS) HIV-related disorders frequently have devastating consequences. Significant progress has been made in the early diagnosis and treatment of the HIV-infected patient. As a result, the prevalence and natural history of neurologic illnesses have changed. This paper reviews the epidemiology, clinical manifestations, and neuropathogenesis of HIV-related CNS disorders. Advances in antiretroviral therapy, neuroprophylaxis, and neuroprotective strategies are also discussed.
Civitello
Lucy
L
Department of Neurology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA. lcivitello@cnmc.org
D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D018696:Neuroprotective Agents / Q000627:therapeutic use; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D018696:Neuroprotective Agents