title: Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet.
abstract: Adiponutrin is a recently identified gene of unknown function that is expressed exclusively in adipose tissues. To provide information about its physiological regulation and possible function, the effect of meal-feeding rats on the expression of adiponutrin mRNA in white adipose tissue was studied. A high-sucrose meal increased adiponutrin mRNA levels by at least 5-fold within 3 h. Post-meal levels returned to pre-meal levels with a half-life of about 5 h. The induction was prevented by injection of actinomycin-D prior to the meal. This pattern of expression was very similar to that seen for leptin mRNA. There were only minimal, or no, effects on acrp30/adiponectin, resistin, adipsin, or stearoyl-CoA desaturase 1. Adiponutrin appears more like leptin with respect to its acute regulation by meal-feeding than to any of the other adipokines or to enzymes directly involved in lipogenesis. This suggests that adiponutrin could be involved in overall energy homeostasis, as is leptin.
authors.affiliation: Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand.
authors.forename: Dagmar A
authors.initials: DA
authors.lastname: Polson
authors.forename: Mary P
authors.initials: MP
authors.lastname: Thompson
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D018797:Cell Cycle Proteins; D011416:Complement Factor D; D003609:Dactinomycin / Q000378:metabolism; D019422:Dietary Sucrose / Q000008:administration & dosage*; D006706:Homeostasis; D006729:Hormones, Ectopic / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000235:genetics / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D020932:Nerve Growth Factor; D019384:Nucleic Acid Synthesis Inhibitors / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D052243:Resistin; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D013230:Stearoyl-CoA Desaturase / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
chemical_list: D052242:Adiponectin; D018797:Cell Cycle Proteins; D019422:Dietary Sucrose; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D008565:Membrane Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D011506:Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D052243:Resistin; C499622:Retn protein, rat; C486575:Retnla protein, rat; C436316:adiponutrin; D003609:Dactinomycin; D020932:Nerve Growth Factor; C490333:Scd1 protein, mouse; D013230:Stearoyl-CoA Desaturase; D012697:Serine Endopeptidases; D011416:Complement Factor D; C493491:complement factor D, mouse