[The effect of interferon alone, cytosine arabinoside alone and their combined effect on hematopoietic progenitors of chronic myeloid leukemia in vitro].
OBJECTIVE
In order to search for more effective treatment regimen of chronic myeloid leukemia (CML).


METHODS
Semisolid culture and conventional chromosome assay were used to evaluate the effect of interferon (IFN) and Ara-c on K562 cell line and BMMNCs from CML patients and normal controls.


RESULTS
IFN had no obvious inhibitory effect on K562 cell. IFN and Ara-c had preferential inhibitory effect on CFU-GM growth of CML and selective cytotoxic effect on CML Ph+ cell. The combination of IFN with Ara-c enhanced the cytotoxic effect of IFN or Ara-c alone on CML cells.


CONCLUSIONS
IFN and Ara-c can be selected for therapy of CML in chronic phase. The combination of IFN with Ara-c may be more effective than IFN or Ara-c alone for the therapy of CML.
Qin
Hui
H
Dept of Medicine, West China Hospital, Sichuan University, Chendu 610041, China.
Yang
Yiming
Y
Liang
Yong
Y
Li
Yun
Y
Zeng
Liming
L
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D020014:K562 Cells / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D003561:Cytarabine; D007372:Interferons