title: Serotonin transporter gene polymorphism and schizoid personality traits in the patients with psychosis and psychiatrically well subjects.
abstract: OBJECTIVE
  serotonin transporter (5-HTT) gene allelic variants were shown to be associated with Neuroticism and Harm Avoidance but the results were not replicated in other studies. The current investigation was undertaken in a further attempt to study the relationship between 5-HTT polymorphism and personality traits.
  
  
  METHODS
  to evaluate a spectrum of personality traits, MMPI was administered to a sample including patients with affective disorders (n=114), patients with schizophrenia spectrum illnesses (n=110) and psychiatrically well controls (n=124). All groups were genotyped for VNTR-17 and functional insertion-deletion (5-HTTLPR) polymorphisms.
  
  
  RESULTS
  an association was found between 5-HTTLPR polymorphism and scores on three MMPI scales: Psychopathic deviance, Paranoia and Schizophrenia in patients with affective disorders and S chizophrenia in normal subjects. Both affected and control individuals with 'ss' genotype exhibited lower scores on these scales.
  
  
  CONCLUSIONS
  we demonstrated that functional deletion/insertion allelic variation associated with decreased expression of serotonin transporter ('s' allele or 'ss' genotype) may restrict expression of schizoid traits in normal subjects and patients with affective disorders.
authors.affiliation: The Preventive Genetics Laboratory, Research Mental Health Center, Zagorodnoe sh 2/2, 113152 Moscow, Russia. golimbet@mail.ru
authors.forename: Vera E
authors.initials: VE
authors.lastname: Golimbet
authors.forename: Margarita V
authors.initials: MV
authors.lastname: Alfimova
authors.forename: Tatyana
authors.initials: T
authors.lastname: Shcherbatikh
authors.forename: Vasili G
authors.initials: VG
authors.lastname: Kaleda
authors.forename: Lilia I
authors.initials: LI
authors.lastname: Abramova
authors.forename: Evgeni I
authors.initials: EI
authors.lastname: Rogaev
mesh_terms: D000328:Adult; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008950:MMPI; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011618:Psychotic Disorders / Q000150:complications*; D012557:Schizoid Personality Disorder / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D012720:Severity of Illness Index
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins