[Study on adriamycin-porous tricalcium phosphate ceramic drug delivery system and its drug release test in vivo].
OBJECTIVE
To manufacture adriamycin-porous tricalcium phosphate (A-PTCP) ceramic drug delivery system (DDS) as a possible method for bone defect treatment after bone tumor operation.


METHODS
A-PTCP DDS was made from putting adriamycin into PTCP. Thirty rabbits were divided randomly into group A(24 rabbits) and group B(6 rabbits). A-PTCP was implanted in the greater trochanter of the right femur in group A. Adriamycin were injected into veins in group B. Muscle around A-PTCP and plasma were taken out at different period. Adriamycin concentrations in muscle and plasma were measured by high performance liquid chromatography (HPLC).


RESULTS
A-PTCP could gradually release adriamycin over 10 weeks. Adriamycin concentrations in the muscle were higher than that in plasma.


CONCLUSIONS
A-PTCP may be a new method for repairing bone defects after bone tumor operation.
You
H B
HB
Department of Orthopedic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang Guangdong, P. R. China 524001.
Chen
A M
AM
Sun
S Z
SZ
D000818:Animals; D001672:Biocompatible Materials; D001859:Bone Neoplasms / Q000378:metabolism; D002130:Calcium Phosphates; D002516:Ceramics; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D005269:Femur / Q000601:surgery; D009132:Muscles / Q000378:metabolism; D019736:Prostheses and Implants; D011817:Rabbits; D011897:Random Allocation
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D004317:Doxorubicin; C018392:tricalcium phosphate