title: Advances in quantitative proteomics using stable isotope tags.
abstract: A great deal of current biological and clinical research is directed at the interpretation of the information contained in the human genome sequence in terms of the structure, function and control of biological systems and processes. Proteomics, the systematic analysis of proteins, is becoming a critical component in this endeavor because proteomic measurements are carried out directly on proteins--the catalysts and effectors of essentially all biological functions. To detect changes in protein profiles that might provide important diagnostic or functional insights, proteomic analyses necessarily have to be quantitative. This article summarizes recent technological advances in quantitative proteomics.
authors.affiliation: Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103-8904, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Flory
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Griffin
authors.forename: Daniel
authors.initials: D
authors.lastname: Martin
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods / Q000639:trends; D006801:Humans; D007554:Isotopes; D013058:Mass Spectrometry; D011506:Proteins / Q000737:chemistry; D020543:Proteome; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D007554:Isotopes; D011506:Proteins; D020543:Proteome