Treatment-related factors and highly active antiretroviral therapy adherence.
Adherence to highly active antiretroviral therapy (HAART) plays a critical role in the effectiveness of HIV treatment. Nevertheless, the complexity of regimens and frequent side effects make HAART extraordinarily difficult to take, and many HIV-infected persons fail to adhere. The current study offers an overview of the relationship between adherence and antiretroviral treatment-related variables. As for other chronic diseases, medication regimen complexity also has an impact on adherence in the management of HIV infection. In particular, the authors discuss the effect of pill burden, dosing frequency, dietary instructions, number and type of different medications prescribed, short- and long-term side effects, convenience, and ability to incorporate the treatment regimen into a daily routine. Medication side effects are common in HAART-treated persons and are associated with concurrent and future nonadherence. Simplification of regimens, adjustment of the drug schedule to the patient's specific lifestyle, and anticipation and self-management of side effects are treatment-based strategies to optimize HAART adherence and ensure the most effective, convenient, safe, and well-tolerated antiretroviral treatment.
Trotta
Maria Paola
MP
Istituto Nazionale per le Malattie Infettive, L. Spallanzani IRCCS, Roma, Italy.
Ammassari
Adriana
A
Melzi
Sara
S
Zaccarelli
Mauro
M
Ladisa
Nicoletta
N
Sighinolfi
Laura
L
Mura
Maria Stella
MS
d'Arminio Monforte
Antonella
A
Antinori
Andrea
A
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000523:psychology; D004032:Diet; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008019:Life Style; D010349:Patient Compliance
D019380:Anti-HIV Agents; D004338:Drug Combinations