Clinical investigation of radiation retinopathy fundus and fluorescein angiographic features.
OBJECTIVE
To investigate the fundus and fluorescein angiographic features in the patients with radiation retinopathy.


METHODS
Color fundus photography and/or fluorescein angiography from 13 patients with nasopharyngeal carcinomas received external beam radiation were retrospectively analyzed.


RESULTS
In this study, 26 damaged eyes of 13 patients developed some degree of radiation retinopathy. The earliest and most common finding was macular microvascular changes (microaneurysms and/or telangiectasia), which was observed in 100% (26/26) of the eyes. Intraretinal hemorrhages, macular capillary nonperfusion, and mascular edema were noted in 84%, 50%, and 42% of the eyes, respectively.


CONCLUSIONS
Radiation retinopathy is common after external beam radiation of nasopharyngeal carcinomas. The prominent changes include macular microvascular changes, intraretinal hemorrhages and macular capillary nonperfusion.
Li
M
M
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Qiu
G
G
Luo
W
W
Ou
J
J
Li
X
X
D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D009887:Ophthalmoscopy; D011832:Radiation Injuries / Q000175:diagnosis*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology