title: Estimation of the supplementary axial wall stress generated at peak flow by an arterial stenosis.
abstract: Mechanical stresses in arterial walls are known to be implicated in the development of atherosclerosis. While shear stress and circumferential stress have received a lot of attention, axial stress has not. Yet, stenoses can be intuitively expected to produce a supplementary axial stress during flow systole in the region immediately proximal to the constriction cone. In this paper, a model for the estimation of this effect is presented, and ten numerical examples are computed. These examples show that the cyclic increase in axial stress can be quite considerable in severe stenoses (typically 120% or more of the normal stress value). This result is in best agreement with the known mechanical or morphological risk factors of stenosis progression and restenosis (hypertension, elevated pulse pressure, degree of stenosis, stenosis geometry, residual stenosis, etc). The supplementary axial stress generated by a stenosis might create the damages in the endothelium and in the elastic membranes which potentiate the action of the other risk factors (hyperlipidaemia, diabetes, etc). It could thus be an important cause of stenosis progression and of restenosis.
authors.affiliation: Cardiology Division, University Hospital of Geneva, CH-1211 Geneva 14, Switzerland.
authors.forename: Pierre-André
authors.initials: PA
authors.lastname: Doriot
mesh_terms: D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D003251:Constriction, Pathologic; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D009038:Motion; D033081:Shear Strength; D013314:Stress, Mechanical