Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise.
It is reported that preexercise hyperhydration caused arterial O(2) tension of horses performing submaximal exercise to decrease further by 15 Torr (Sosa-Leon L, Hodgson DR, Evans DL, Ray SP, Carlson GP, and Rose RJ. Equine Vet J Suppl 34: 425-429, 2002). Because hydration status is important to optimal athletic performance and thermoregulation during exercise, the present study examined whether preexercise induction of hypervolemia would similarly accentuate the arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise. Two sets of experiments (namely, control and hypervolemia studies) were carried out on seven healthy, exercise-trained Thoroughbred horses in random order, 7 days apart. In resting horses, an 18.0 +/- 1.8% increase in plasma volume was induced with NaCl (0.30-0.45 g/kg dissolved in 1,500 ml H(2)O) administered via a nasogastric tube, 285-290 min preexercise. Blood-gas and pH measurements as well as concentrations of plasma protein, hemoglobin, and blood lactate were determined at rest and during incremental exercise leading to maximal exertion (14 m/s on a 3.5% uphill grade) that induced pulmonary hemorrhage in all horses in both treatments. In both treatments, significant arterial hypoxemia, desaturation of hemoglobin, hypercapnia, acidosis, and hyperthermia developed during maximal exercise, but statistically significant differences between treatments were not found. Thus preexercise 18% expansion of plasma volume failed to significantly affect the development and/or severity of arterial hypoxemia in Thoroughbreds performing maximal exercise. Although blood lactate concentration and arterial pH were unaffected, hemodilution caused in this manner resulted in a significant (P < 0.01) attenuation of the exercise-induced expansion of the arterial-to-mixed venous blood O(2) content gradient.
Manohar
Murli
M
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. mmanohar@uiuc.edu
Goetz
Thomas E
TE
Hassan
Aslam S
AS
D000822:Animal Husbandry; D000818:Animals; D001158:Arteries; D001798:Blood Proteins / Q000032:analysis; D001810:Blood Volume; D001831:Body Temperature / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006736:Horses / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000209:etiology* / Q000503:physiopathology*; D019344:Lactic Acid / Q000097:blood; D009043:Motor Activity / Q000502:physiology*; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis; D010313:Partial Pressure; D012146:Rest / Q000502:physiology; D014680:Veins
D001798:Blood Proteins; D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen