title: Efficacy of danofloxacin 18% injectable solution in the treatment of Escherichia coli diarrhoea in young calves in Europe.
abstract: The efficacy of danofloxacin 18% against naturally occurring Escherichia coli diarrhoea was investigated in calves at seven European sites. Treatment commenced on day 0, with either a single subcutaneous injection of danofloxacin 18% (n=267) at 6 mg/kg repeated on day 2 if required, or reference product containing baquiloprim/sulphadimidine (n=37) or gentamicin (n=98) administered as recommended. E. coli was isolated from 90% to 100% of calves pre-treatment, and the prevalence of serotypes K99 and F41 was 8-46% and 46-92%, respectively. In both treatments, the majority of calves (93.2-93.9%) showed clinical improvement and completed the studies. There were significant reductions for both treatments, in severity of clinical signs on days 4 and 10 compared to day 0 (P<0.0001), and between days 4 and 10 (P<0.05), but no significant differences between treatments (P>0.05). Danofloxacin 18% was clinically safe, and as effective as the reference products in the treatment of E. coli diarrhoea in calves.
authors.affiliation: Pfizer Animal Health Group, Pfizer Ltd., Sandwich, Kent CT13 9NJ, UK. simon_sunderland@sandwich.pfizer.com
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Sunderland
authors.forename: P
authors.initials: P
authors.lastname: Sarasola
authors.forename: T G
authors.initials: TG
authors.lastname: Rowan
authors.forename: C J
authors.initials: CJ
authors.lastname: Giles
authors.forename: D G
authors.initials: DG
authors.lastname: Smith
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000382:microbiology; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology / Q000662:veterinary*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology / Q000662:veterinary*; D005060:Europe; D024841:Fluoroquinolones; D012996:Solutions / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D012996:Solutions; C068581:danofloxacin