The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients.
Electrooculography (EOG) recordings in 21 L-DOPA-naive patients suffering from Parkinson's disease (PD) were made before and after apomorphine subcutaneous administration (ASA). The effect of apomorphine on smooth pursuit eye movements (SPEM) was studied. Age-matched healthy subjects, who underwent SPEM recordings without the ASA procedure, were examined in order to compare baseline SPEM. EOG recordings were used to compare the patient group and the control group, and to compare the SPEM before and after ASA within the patient group. Significant differences in SPEM were found between both groups, as well as in the SPEM before and after ASA. The theory that SPEM is disturbed in early PD patients was confirmed. The dopaminergic control of horizontal SPEM is supposed.
Bares
Martin
M
1st Department of Neurology, Masaryk University, St Anne Hospital, Pekarská 53, 656 91, Brno, Czech Republic. martin.bares@fnusa.cz
Brázdil
Milan
M
Kanovský
Petr
P
Jurák
Pavel
P
Daniel
Pavel
P
Kukleta
Miloslav
M
Rektor
Ivan
I
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001058:Apomorphine / Q000494:pharmacology*; D004585:Electrooculography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D011698:Pursuit, Smooth / Q000187:drug effects* / Q000502:physiology
D001058:Apomorphine