[Assessment on effect of treatment of chronic plaque type psoriasis by combination therapy of composite shendi decoction and diyin tablet].
OBJECTIVE
To seek for a better therapy for chronic plaque type psoriasis.


METHODS
The effect of 35 patients in the tested group treated with combination therapy of composite Shendi Decoction (CSDD) and Diyin Tablet (DYT) was observed and compared with the effect of those treated by CSDD alone (25 cases) or by DYT alone (18 cases) as the control groups.


RESULTS
The total effective rate in the treated group was 94.29%, and that in the two control groups was 88.00% and 83.33% respectively. The markedly effective rate in the treated group was 62.86%, and that for the control group was 36.00% and 27.78% respectively. Ridit test showed significant difference among the effectiveness in the three groups, while chi 2 showed the difference of the total effective rate in the three groups was insignificant, but that of the markedly effective rate was significant. Serum IL-8 and plasma endothelin levels of 11 cases in the treated group were examined before and after treatment, the results showed that both the two parameters were reduced after the combination therapy.


CONCLUSIONS
The effect of combination therapy of CSDD and DYT was better than that of CSDD or DYT alone, therefore, it is worth further studying and spreading.
Gao
B A
BA
Guang An Men Hospital, China Academy of TCM, Beijing 100053.
Xu
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D016209:Interleukin-8