Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis.
Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS). In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC). Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry. MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin. These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response.
Kennel De March
A
A
Laboratoire d'Immunologie du CHU, Faculté de Médecine, BP 184, 54500 Vandoeuvre les, 54000, Nancy, France.
De Bouwerie
M
M
Kolopp-Sarda
M N
MN
Faure
G C
GC
Béné
M C
MC
Bernard
C C A
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000921:Antibody-Producing Cells / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology*; D000071797:Butyrophilins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000097:blood
D000071797:Butyrophilins; D007132:Immunoglobulin Isotypes; C571326:MOG protein, human; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D016212:Transforming Growth Factor beta