title: Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler.
abstract: A mature male rottweiler was evaluated for acute collapse and abdominal pain. The history consisted of concurrent administration of meloxicam and aspirin. On exploratory laparotomy, a large perforated ulcer was discovered in the proximal duodenum, with secondary peritonitis. The pathogenesis of NSAID-induced gastrointestinal ulceration and the supposed safety of COX-2 selective agents are discussed.
authors.affiliation: Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
authors.forename: Suma
authors.initials: S
authors.lastname: Reed
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000601:surgery; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D008297:Male; D000077239:Meloxicam; D010439:Peptic Ulcer Perforation / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary*; D013843:Thiazines / Q000009:adverse effects / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D001241:Aspirin; D000077239:Meloxicam