title: The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare.
abstract: Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.
authors.forename: Sanae
authors.initials: S
authors.lastname: El Bardai
authors.forename: Nicole
authors.initials: N
authors.lastname: Morel
authors.forename: Maurice
authors.initials: M
authors.lastname: Wibo
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fabre
authors.forename: Gabriel
authors.initials: G
authors.lastname: Llabres
authors.forename: Badiaa
authors.initials: B
authors.lastname: Lyoussi
authors.forename: Joëlle
authors.initials: J
authors.lastname: Quetin-Leclercq
mesh_terms: D000818:Animals; D001011:Aorta; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D027522:Marrubium / Q000737:chemistry*; D009018:Morocco; D010946:Plants, Medicinal; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D004224:Diterpenes; D005663:Furans; C473344:marrubenol; D011189:Potassium Chloride; C105731:marrubiin