Photosynthesis of furocoumarin- and furochromone-types potential intercalative alkylating and oxidizing agents of DNA through photooxidations using gamma-ray.
The photooxygenation of imperatorin (1a) under gamma-ray irradiation afforded the hydroperoxides 2a and 3a. Similarly, the photooxygenation of alloimperatorin (1b) gave the hydroperoxide (2b). Visnagin (1c) was also photooxygenated to give the hydroperoxide (2c) as sole product. On the other hand, the photooxygenation of khellin (1d) gave the endoperoxide (2d) as a sole product. The epoxidation of imperatorin (1a) using hydrogen peroxide under gamma-ray irradiation afforded the epoxide 5a. Similarly visnagin (1c) and khellin (1d) were epoxidized to give the epoxides 5c and 5d.
Elgendy
E M
EM
Department of Home Economy, Faculty of Specific Education, Mansoura University, Mansoura, Egypt.
Ramadan
A A
AA
Fadaly
W
W
Hammouda
M
M
D000477:Alkylating Agents / Q000138:chemical synthesis*; D002867:Chromones / Q000138:chemical synthesis*; D004247:DNA / Q000187:drug effects*; D004852:Epoxy Compounds / Q000138:chemical synthesis; D005663:Furans / Q000138:chemical synthesis*; D011564:Furocoumarins / Q000138:chemical synthesis*; D005720:Gamma Rays; D007364:Intercalating Agents / Q000138:chemical synthesis*; D007666:Khellin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000528:radiation effects; D016877:Oxidants / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010777:Photochemistry
D000477:Alkylating Agents; D002867:Chromones; D004852:Epoxy Compounds; D005663:Furans; D011564:Furocoumarins; D007364:Intercalating Agents; D016877:Oxidants; D007666:Khellin; D004247:DNA; C044999:visnagin