[Pharmacological comparison between virosecurinine and securinine].
Pharmacological activities of virosecurinine (Vse) and securinine (Sec) were studied. The results showed that acute toxicity of Vse was 1/13.6 that of Sec, and Vse had no convulsive effects on rats or frogs, while Sec had. The results also showed that Vse and Sec could elevate blood pressure and excite respiration in cats.
Pu
H
H
Bio-Engineering Instiute, Jinan University, Guangzhou 510632.
Zhao
J
J
Pong
B
B
Xu
S
S
D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001381:Azepines / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology / Q000633:toxicity; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones / Q000494:pharmacology* / Q000633:toxicity; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D011898:Ranidae; D051381:Rats; D012119:Respiration / Q000187:drug effects
D000470:Alkaloids; D001381:Azepines; D004365:Drugs, Chinese Herbal; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; C012607:virosecurinine; C000785:securinine