[Therapeutic effect of recombinant human interleukin-11 on thrombocytopenia models induced by anti-platelet serum in guinea pigs].
OBJECTIVE
To observe the effect of recombinant human interleukin-11 on the platelet counts and the CFU-Meg of the marrow cell culture.


METHODS
Thrombocytopenia models of guinea pigs were made by injecting subcutaneously anti-platelet serum.


RESULTS
200, 100, and 50 micrograms.kg-1 of rHuIL-11 increased the CFU-Meg of the marrow cell culture and the peripheral platelet, showing a significant difference from that of the control group (P < 0.05).


CONCLUSIONS
rHuIL-11 has a significantly therapeutic effect on thrombocytopenia models induced by anti-platelet serum in guinea pigs.
Lai
Fu-ying
FY
Central Laboratory, Xiangya Hospital, Central South University, Changsha 410078, China.
Fang
Fang
F
Sun
Li
L
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007106:Immune Sera; D017370:Interleukin-11 / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D008297:Male; D010976:Platelet Count; D011897:Random Allocation; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology; D013921:Thrombocytopenia / Q000097:blood* / Q000209:etiology / Q000378:metabolism
D007106:Immune Sera; D017370:Interleukin-11; D011994:Recombinant Proteins