[LC-MS analysis of related substances in ampicillin and amoxicillin].
OBJECTIVE
To analyze the related substances in ampicillin and amoxicillin and determine the related substances in products.


METHODS
By using HPLC, electrospray ionzation and selective ion monitoring mass spectrum method, accelerated samples were analyzed for determination the related substances in ampicillin and amoxicillin.


RESULTS
Thirteen related substances in ampicillin and 9 related substances in amoxicillin were determined.


CONCLUSIONS
The results are useful to quality control and stability study for ampicillin and amoxicillin.
Niu
C Q
CQ
Research and Development Drug Center, North China Pharmaceutical Corporation, Shijiazhuang 050015, China. niuchangqun@yeal.net
Zhu
S Q
SQ
D000658:Amoxicillin / Q000032:analysis* / Q000737:chemistry; D000667:Ampicillin / Q000032:analysis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D011786:Quality Control; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D000658:Amoxicillin