Preparation and in vitro evaluation of modified release ketoprofen microsponges.
Microsponges containing ketoprofen and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The effects of different mixing speeds, drug-polymer ratios, solvent-polymer ratios on the physical characteristics of the microsponges as well as the in vitro release rate of the drug from the microsponges were investigated. All the factors studied had an influence on the physical characteristics of the microsponges. In vitro dissolution results showed that the release rate of ketoprofen was modified in all formulations.
Comoğlu
Tansel
T
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06100 Tandoğan, Ankara, Turkey.
Gönül
Nurşin
N
Baykara
Tamer
T
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007660:Ketoprofen / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008863:Microspheres
D000180:Acrylic Resins; D004337:Drug Carriers; C050528:Eudragit RS; D007660:Ketoprofen