[The treatment effect of ribavirin to hemorrhagic fever with renal syndrome on the kinetics of serum creatine phosphate kinase isoenzyme].
OBJECTIVE
To study the effect of ribavirin treatment on kinetics of serum creatine phosphate kinase isoenzyme(CK-MB) of patients with hemoarrhagic fever with renal syndrome(HFRS).


METHODS
CK-MB levels in 155 HFRS patients treated with larger dose of ribavirin and with routine therapeutic dose were observed dynamicaly, using randomly controlled double-blind method. In addition, CK-MB levels in different disease phases and different clinical types of HFRS were compared.


RESULTS
The results showed that CK-MB levels were significantly increased in febrile phase and decreased gradually to normal during convalescent phase in both groups, but in febrile phase, CK-MB levels in ribavirin-treated group and control group were 55.25 +/- 18.25 IU/L and 69.63 +/- 23.52 IU/L, respectively, the treated group had a lower level (P < 0.05). The severe and critical group treated by ribavirin showed a lower CK-MB level of 47.74 +/- 24.82 IU/L, while the control group showed a higher level of 66.08 +/- 25.01 IU/L(P < 0.05).


CONCLUSIONS
These results indicated that an early application of large dose of ribavirin in treatment of HFRS can reduce the serum CK-MB levels in patients with HFRS.
Zhang
Q
Q
First Affiliated Hospital of Hubei Medical University, Wuhan 430060.
Tang
R
R
Yuan
G
G
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000378:metabolism*; D052279:Creatine Kinase, MB Form; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000627:therapeutic use*
D000998:Antiviral Agents; D007527:Isoenzymes; D012254:Ribavirin; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form