title: Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsia.
abstract: The present study investigated plasma activity of 5'-nucleotidase, a key enzyme in the production of adenosine, in pre-eclampsia, and evaluated the relationship between changes in 5'-nucleotidase activity, and levels of uric acid, endproduct of the purine metabolism, and the severity of pre-eclampsia. We measured plasma 5'-nucleotidase activities and uric acid levels in women with 18 normal pregnancies, mild and severe pre-eclampsia. In mild and severe pre-eclampsia, plasma 5'-nucleotidase activities and uric acid levels were significantly increased compared with those in normal pregnancy (p < 0.05). Plasma 5'-nucleotidase activity increased according to increases in uric acid levels and the severity of pre-eclampsia. These results suggest that increased plasma 5'-nucleotidase activity may, at least in part, be related to changes in purine metabolism in pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yoneyama
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Rintaro
authors.initials: R
authors.lastname: Sawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Otsubo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miura
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishino
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kiyokawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Doi
authors.forename: Koichi
authors.initials: K
authors.lastname: Yoneyama
authors.forename: Hajime
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
mesh_terms: D015720:5'-Nucleotidase / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D015720:5'-Nucleotidase