[Toxicity of manganese exposure on the postnatal development of brain in mice].
The toxicity of manganese exposure on the postnatal development of brain in mice was investigated. Muscle motor ability was examined by Morris Water Maze, spontaneous action by Open Field Maze, neuro-anxiety by Elevated Plus Arms Maze. Lipid peroxides (LPO) level and superoxide dismutase (SOD) activity of brain was detected by neurobiochemical assay; glial fibrillary protein acid (GFAP) immunoreactivity was observed by cytoimmunochemistry. The results showed that in Mn-exposed group: (1) the length of body was significantly reduced; (2) the latency for reaching the platform above water in Morris Water Maze Test was longer, the walking squares and spontaneous rears in Open Field Maze, and the entries to open arms and the ratio of entries for open arms to entries for total arms in Elevated Plus Arms Maze were significantly increased; (3) LPO was obvious increased and SOD activity was decreased in brain; (4) GFAP immuno-reactivity and the average proportional density of GFAP-positive products in dendritic gyrus of cerebral cortex were significantly increased. More significant changes had been observed in the high Mn-exposed group. It was suggested that manganese exposure could lead to behavioral, neurobiochemical and cytoimmunochemical toxicity of brain in postnatal development.
Zhang
Dexing
D
Guangdong College of Pharmacy, Guangzhou 510224, China.
He
Xinhong
X
Huang
Shaoming
S
Li
Yanhua
Y
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D020149:Manganese Poisoning / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D009043:Motor Activity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013482:Superoxide Dismutase / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D008054:Lipid Peroxides; D013482:Superoxide Dismutase