title: [Mutagenic activity of organic pollutants extracted from waters in Guanting Reservoir and Yongding River].
abstract: Water samples collected from Guanting Reservoir and Yongding River in July 1999 were examined by Ames test to evaluate the mutagenic activity of organic pollutants. The samples have been concentrated by using XAD-2 resin filled columns. In the test with strain TA98, direct mutagenic effects (-S9) were observed in water extracted from Bridge No.8 and Yanchi at the dosage of 0.8 L/plate, indicating the existence of direct frame shift mutagens. The mutagenic effects disappeared after addition of S9, indicating no pro-mutagen in the samples. In the test with strain TA100, direct base pair substitute mutagenic effect was observed only in the sample from Bridge No. 8 at the dosage of 0.4 L/plate. When adding S9, suspicious positive reaction could exist at the dosage of 0.8 L/plate. The results demonstrated that the water in Yongding River has been heavily polluted by mutagens, for which further studies should be carried out to identify the sources and types of these mutagens.
authors.affiliation: Research Center for Eco-environment Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: M
authors.initials: M
authors.lastname: Ma
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Shang
mesh_terms: D000818:Animals; D002681:China; D009152:Mutagenicity Tests; D051381:Rats; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply / Q000032:analysis*
chemical_list: D014874:Water Pollutants, Chemical