title: Platelet ADP receptors and their antagonists.
abstract: ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential target for antithrombotic drugs. The knowledge of the ADP-receptors has been amplified by recent discoveries. This review highlights the ADP-receptors models and their antagonists described in the recent literature, mainly the thienopyridine derivatives.
authors.affiliation: Natural and Synthetic Drugs Research Center - Medicinal Chemistry. Avenue de l'Hôpital,1, B-4000 Liège, Belgium.
authors.forename: Patricia
authors.initials: P
authors.lastname: Benoit
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dogné
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D058919:Purinergic P2 Receptor Antagonists; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D018048:Receptors, Purinergic P2 / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D058919:Purinergic P2 Receptor Antagonists; D011725:Pyridines; D018048:Receptors, Purinergic P2; C446540:thienopyridine