title: Solution to the problem of interferences in electrochemical sensors using the fill-and-flow channel biosensor.
abstract: A generic fill-and-flow channel biosensor with upstream electrodes to determine the extent of interferences in the sample is described. A pair of upstream electrodes poised at a suitable potential allows both the calculation of the extent of removal of interfering agents and the effect of interfering agents at the detector electrode. A model was developed and tested that predicts the concentrations of all species throughout the channel and, hence, the current at each electrode due to each species. This enables correction of the detector electrode current and a more accurate determination of the analyte concentration. The concept was applied to a biosensor for the determination of glucose in the presence of ascorbic acid, acetamidophenol, and uric acid, as well as glucose in wine samples containing polyphenolic interfering agents.
authors.affiliation: School of Chemical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: D Brynn
authors.initials: DB
authors.lastname: Hibbert
authors.forename: J Justin
authors.initials: JJ
authors.lastname: Gooding
mesh_terms: D001205:Ascorbic Acid; D015374:Biosensing Techniques / Q000379:methods* / Q000592:standards; D004566:Electrodes / Q000592:standards; D005947:Glucose / Q000032:analysis; D014920:Wine / Q000032:analysis
chemical_list: D005947:Glucose; D001205:Ascorbic Acid