title: Studies on the mode of action of reutericyclin.
abstract: The mode of action of reutericyclin was determined with fluorescent dyes that probed the permeability of the cytoplasmic membrane by large molecules, protons, and potassium. A comparison of reutericyclin activity with those of nisin, nigericin, and valinomycin demonstrated that reutericyclin does not form pores but selectively dissipates the transmembrane proton potential.
authors.affiliation: Lehrstuhl für Technische Mikrobiologie, TU München, 85350 Freising, Germany. michael.gaenzle@wzw.tum.de
authors.forename: Michael G
authors.initials: MG
authors.lastname: Gänzle
authors.forename: Rudi F
authors.initials: RF
authors.lastname: Vogel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D005456:Fluorescent Dyes / Q000378:metabolism; D007778:Lactobacillus / Q000187:drug effects* / Q000254:growth & development; D008564:Membrane Potentials / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009550:Nigericin / Q000494:pharmacology; D009561:Nisin / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013720:Tenuazonic Acid / Q000031:analogs & derivatives; D014634:Valinomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; C416127:reutericyclin; D009561:Nisin; D014634:Valinomycin; D013720:Tenuazonic Acid; D009550:Nigericin; D011188:Potassium