Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28.
The immunogenicity of human leukocyte antigen (HLA)-A2 versus HLA-A28 was analyzed by antibody production, cytotoxic T-lymphocyte (CTL) induction, and graft survival. We observed that an HLA-A2 mismatched child in HLA-A28 women leads to HLA-A2 specific antibodies in 32% of the women (n=31), whereas in the case of an HLA-A28 child and HLA-A2 women (n=30), no HLA-A28 specific antibodies were found ( P<0.002). Also, the CTL precursor frequencies were significantly lower against HLA-A28 compared with CTLp frequencies against HLA-A2 ( P=0.012). Finally, the kidney graft survival was slightly better in HLA-A2 positive recipients transplanted with HLA-A28 mismatches. We can conclude that single HLA-A28 mismatches are less immunogenic in HLA-A2 individuals compared with single HLA-A2 mismatches in HLA-A28 individuals, which is probably because the mismatched epitopes on the HLA-A2 molecule are unique epitopes, whereas the mismatched epitopes on HLA-A28 are shared by other HLA-A and HLA-B molecules.
Dankers
Marlies K A
MK
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Roelen
Dave L
DL
Van Der Meer-Prins
Ellen M W
EM
De Lange
Peter
P
Korfage
Nelleke
N
Smits
Jacqueline M A
JM
Persijn
Guido G
GG
Welsh
Ken I
KI
Doxiadis
Ilias I N
II
Claas
Frans H J
FH
D000906:Antibodies / Q000097:blood; D000939:Epitopes / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology; D015789:HLA-A2 Antigen / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D066298:In Vitro Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D011247:Pregnancy; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000906:Antibodies; D000939:Epitopes; D015234:HLA-A Antigens; D015789:HLA-A2 Antigen; C037164:HLA-A28 antigen