Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation.
The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.
Yan
Siucheong
S
Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
Wong
Iris L K
IL
Chow
Larry M C
LM
Sun
Hongzhe
H
D000965:Antimony / Q000737:chemistry*; D000977:Antiparasitic Agents / Q000737:chemistry*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013095:Spermidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013696:Temperature
D000977:Antiparasitic Agents; C044809:trypanothione; D000965:Antimony; D005978:Glutathione; D013095:Spermidine