[Effect and mechanism study of kidney tonifying and blood circulation activating Chinese drugs on development of mammary glands in female juvenile rats].
OBJECTIVE
To study the effect and mechanism of Kidney tonifying and blood circulation activating Chinese drugs (KB) on development of mammary gland.


METHODS
Using the female juvenile rats as the experimental targets, the level of serum hormone, the amount and affinity of estradiol receptor (ER) and progesterone receptor (PR) as well as the DNA content and relative weight of the rats' mammary glands were measured to study the effect of KB at the pre-receptor, receptor and post-receptor level.


RESULTS
KB markedly enhanced the serum level of estradiol, progesterone and the growth hormone (GH) at pre-receptor level, increased the number and affinity of estradiol and progesterone receptors both in the cytoplasm and nucleus at the receptor level. While at the level of post-receptor, it increased the DNA content and the weight index of mammary glands.


CONCLUSIONS
The Kidney tonifying and blood circulation activating Chinese drugs are effective in promoting the growth and development of mammary glands.
Li
P Y
PY
Gynecology Department of Guangzhou University of TCM, Guangzhou 510407.
Ouyang
H Q
HQ
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D011959:Receptors, Estradiol / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol