Omega-3 fatty acids: implications for the treatment of tumor-associated inflammation.
Our in vivo and in vitro studies using omega-3 fatty acids (FA) have provided insight into the biological effects and mechanisms of their anti-inflammatory action(s). The implications for this research are profound because there are few nutritional therapies available that have the potential to be clinically effective in malignancies and other chronic inflammatory conditions as omega-3 FA. In this summary of experiments the biological effects of omega-3 FA are discussed and the potential mechanisms of action presented.
Jho
David
D
Department of Surgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Babcock
Tricia A
TA
Helton
W Scott
WS
Espat
N Joseph
NJ
D043925:Angiogenesis Inducing Agents / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002100:Cachexia / Q000503:physiopathology / Q000517:prevention & control; D002478:Cells, Cultured; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D015232:Dinoprostone / Q000096:biosynthesis; D015118:Eicosapentaenoic Acid; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use; D005354:Fibrosarcoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D007249:Inflammation; D016753:Interleukin-10 / Q000096:biosynthesis; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D009368:Neoplasm Transplantation; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A
D043925:Angiogenesis Inducing Agents; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D007527:Isoenzymes; D016328:NF-kappa B; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D025801:Ubiquitin; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10; D015118:Eicosapentaenoic Acid; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone