Role of serine/threonine protein phosphatase in Alzheimer's disease.
Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer's disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.
Tian
Qing
Q
Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
Wang
Jianzhi
J
D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000473:pathology; D009473:Neuronal Plasticity; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity
D016229:Amyloid beta-Peptides; D008869:Microtubule-Associated Proteins; D010749:Phosphoprotein Phosphatases