title: Comparison of separation conditions and ionization methods for the liquid chromatography-mass spectrometric determination of sulfonamides.
abstract: The effects of the type and concentration of buffer, composition of the mobile phase and the ionization mode, used for the separation and detection of sulfonamides with LC-MS, were studied. Five typical sulfonamides were selected as target compounds and beef meat was selected as a matrix sample. For the separation of sulfonamides, 0.05 M NH4Ac in 13-15% aqueous acetonitrile, APCl ionization was more effective than ESI with regard to separation efficiency and the detection sensitivity.
authors.affiliation: Organic Analysis Laboratory, Division of Chemical Metrology and Materials Evaluation, Korea Research Institute of standards and Science, Yusong, Daejon 305-600, Republic of Korea. dhkim@kriss.re.kr
authors.forename: Dal-Ho
authors.initials: DH
authors.lastname: Kim
authors.forename: Dai Woon
authors.initials: DW
authors.lastname: Lee
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D004350:Drug Residues / Q000032:analysis*; D008461:Meat Products / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013449:Sulfonamides / Q000032:analysis*
chemical_list: D013449:Sulfonamides