Correlation between structure, aggregation behaviour and cellular toxicity of anti-HIV catanionic analogues of galactosylceramide.
The self-association process of catanionic analogues of galactosylceramide and in particular the arrangement of their hydrophobic part seems to play a key role in their cellular toxicity
Blanzat
Muriel
M
Laboratoire des Interactions Moléculaire et Réactivité Chimique et Photochimique, CNRS UMR 5623, Université P. Sabatier, 118 route de Narbonne, 31062 Toulouse cedex, France. blanzat@chimie.ups-tlse.fr
Perez
Emile
E
Rico-Lattes
Isabelle
I
Lattesa
Armand
A
Gulik
Annette
A
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects*; D019281:Dimerization; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D005699:Galactosylceramides