[Effect of testosterone and progesterone on carboxypeptidase H activity during stress in mice].
It was found that testosterone propionate (3 mg/kg of body weight) and progesterone (1 mg/kg of body weight) partially prevent an augmentation of the carboxypeptidase H activity in the mouse pituitary gland under stress caused by a single intraperitoneal administration of olive oil. In testicles, testosterone prevented augmentation of the enzyme activity within 0.5 hours but increased it through in 4 and 24 hours after treatment. Progesterone in testicles augmented the enzyme activity within 0.5 hours, but not in 4 and 24 hours. Sex steroids were not affected by stressinduced carboxypeptidase H activity in hypothalamus and adrenal medulla. It was concluded that carboxypeptidase H did not take part in integration of hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis under the stress.
Vernigora
A N
AN
V. G. Belinsky Penza State Pedagogical University, 37 Lermontov St., Penza 440028, Russia.
Saldaev
D A
DA
Gengin
M T
MT
D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology; D013312:Stress, Physiological / Q000201:enzymology*; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D002268:Carboxypeptidases; D043423:Carboxypeptidase H