Conclusion. Lessons from the novel D2 dopamine receptor, beta2-adrenoceptor agonist, Viozan: chronic obstructive pulmonary disease and drug development implications.
The development of novel drugs for the treatment of chronic obstructive pulmonary disease (COPD) poses significant challenges. The mechanisms through which the chronic symptoms of COPD arise are poorly understood, making identification of potential therapeutic targets and in vivo evaluation of potential therapies extremely difficult. Despite these challenges, a unique approach of combined D2 dopamine, beta2-adrenoceptor agonism was identified as a valid potential target for the treatment of key COPD symptoms, the therapeutic potential of which was investigated in a series of preclinical evaluations. Subsequent clinical assessment has amassed a wealth of data from over 4000 patients, providing valuable insights into COPD, clinical trial design and the value of patient self-assessment tools.
Calverley
P
P
University Department of Medicine, University Hospital Aintree, Liverpool, UK. pmacal@liverpool.ac.uk
Keating
E T
ET
Goldman
M
M
Casty
F
F
D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy; D015195:Drug Design; D004417:Dyspnea / Q000188:drug therapy; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D018343:Receptors, Adrenergic, beta-2 / Q000627:therapeutic use; D017448:Receptors, Dopamine D2 / Q000819:agonists* / Q000627:therapeutic use; D012107:Research Design; D013183:Sputum; D013844:Thiazoles / Q000627:therapeutic use*
D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D018343:Receptors, Adrenergic, beta-2; D017448:Receptors, Dopamine D2; D013844:Thiazoles; C116267:sibenadet