Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type.
The exact relationship between lymphomatoid granulomatosis (LyG) and posttransplant lymphoproliferative disorders (PTLDs) is not clear. Both are observed in immunodeficient patients and are Epstein-Barr virus driven. These disorders are, however, considered distinct based upon the immune response elicited; LyG is T-cell rich while PTLDs are T-cell poor. We describe a case of LyG-type diffuse large B-cell lymphoma (DLBCL) in a lung transplant recipient. The unusual features include rare occurrence of LyG in a posttransplant setting, systemic involvement by LyG variant of DLBCL in a solid organ transplant recipient, paucity of T-cells in this LyG type lymphoma, and subcutaneous panniculitic pattern in a B-cell lymphoproliferative disorder. This first report of systemic LyG variant of DLBCL in a posttransplant setting has features suggesting similarities and overlap between LyG and PTLD.
Saxena
A
A
Department of Pathology, Royal University Hospital, Saskatoon SK S7 N OW8, Canada. saxena@sask.usask.ca
Dyker
K M
KM
Angel
S
S
Moshynska
O
O
Dharampaul
S
S
Cockroft
D W
DW
D004273:DNA, Neoplasm / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology; D017809:Fatal Outcome; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000821:virology; D008230:Lymphomatoid Granulomatosis / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015434:Panniculitis / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications; D012367:RNA, Viral / Q000032:analysis; D016601:RNA-Binding Proteins / Q000032:analysis; D013902:Radiography, Thoracic; D012269:Ribosomal Proteins; D014057:Tomography, X-Ray Computed
D004273:DNA, Neoplasm; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human