Effects of adrenomedullin on the contraction of gastric arteries during reserpine-induced gastric ulcer.
Adrenomedullin (100 ng/kg, s.c.) prevents reserpine-induced damage of gastric mucosa. In the model of in vitro gastric arteries from reserpine-treated rats, adrenomedullin pre-treatment resulted in a decrease of the vasoconstriction in response to 5-hydroxytryptamine. In contrast, adrenomedullin pre-treatment of rat with intact gastric mucosa did not affect the vasoconstriction to 5-hydroxytryptamine. In the presence of the NOS inhibitor N(G)-nitro-L-arginine, the responsiveness to 5-hydroxytryptamine in gastric arteries from rats treated with reserpine + adrenomedullin was enhanced to the same level of rats treated with reserpine alone. The anti-ulcer effect of adrenomedullin could therefore be related, at least in part, to an increase of blood flow at the gastric mucosa, by a mechanism involving nitric oxide.
Salomone
Salvatore
S
Dipartimento di Farmacologia Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catania, Viale A Doria 6, 95125 Catania, Italy.
Caruso
Antonina
A
Cutuli
Vincenza Maria
VM
Mangano
Nunzio Guido
NG
Prato
Agata
A
Amico-Roxas
Matilde
M
Bianchi
Alfredo
A
Clementi
Giuseppe
G
D053607:Adrenomedullin; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000633:toxicity*; D013270:Stomach / Q000098:blood supply*; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000503:physiopathology
D010455:Peptides; D053607:Adrenomedullin; D012110:Reserpine