Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates.
Platelet polymorphisms (Kozak, VNTR and HPA-2) within glycoprotein (GP)Ib alpha may be associated with an increased risk of arterial thrombosis. However, the functional role of these polymorphisms has not been clarified. Their influence on platelet plug formation under high shear rates was, therefore, examined in 233 healthy individuals. Collagen-adrenaline-induced closure time was shorter in carriers of the C/D versus C/C VNTR allele and in homozygotes with the (-5)T/T versus (-5)C/T Kozak genotype as determined by novel polymerase chain reaction methods. The HPA-2 genotype had no effects, and the density of GPIb alpha molecules was not influenced by GPIb alpha genotypes.
Jilma-Stohlawetz
Petra
P
Department of Clinical Pharmacology-TARGET, Vienna University, Austria.
Homoncik
Monika
M
Jilma
Bernd
B
Knechtelsdorfer
Maarten
M
Unger
Petra
P
Mannhalter
Christine
C
Santoso
Sentot
S
Panzer
Simon
S
D000328:Adult; D000941:Antigens / Q000032:analysis; D005260:Female; D005838:Genotype; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000235:genetics*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; D019038:Platelet Glycoprotein GPIb-IX Complex; C029417:Von Willebrand antigen; D014841:von Willebrand Factor