[Adrenocortical tumors with neuroendocrine differentiation].
18 adrenocortical tumours and 5 pheochromocytomas were studied immunohistochemically. Expression of synaptophysin and chromogranin A was found in cells of cortical adenomas, "frontier" neoplasms and in 20-75% of carcinoma cells, this ultramicroscopically was confirmed by observation of typical neuroendocrine granules. Some groups of cells of cortico-medullary tumours also expressed proteins of neural differentiation (protein S-100).
Kazantseva
I A
IA
Moscow Region Research Clinical Institute, 129110, Moscow.
Poliakova
G A
GA
Gurevich
L G
LG
Morozov
I A
IA
Bezuglova
T V
TV
Smirnov
V B
VB
D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism / Q000473:pathology*; D018246:Adrenocortical Adenoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018268:Adrenocortical Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002454:Cell Differentiation; D002864:Chromogranins / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism* / Q000648:ultrastructure; D010673:Pheochromocytoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D009418:S100 Proteins / Q000378:metabolism / Q000648:ultrastructure; D016708:Synaptophysin / Q000378:metabolism / Q000648:ultrastructure
D002864:Chromogranins; D009418:S100 Proteins; D016708:Synaptophysin