title: Mechanisms of ischemic brain damage.
abstract: Neurologic complications from cerebral ischemia occur frequently following cardiac arrest, as well as in the perioperative period in cardiac surgery. The cellular and molecular mechanisms of cerebral ischemia are complex. This article discusses several important cell death and salvage pathways that are important in experimental cerebral ischemia that may be critical to outcome in clinical brain injury.
authors.affiliation: Meyer 8-140, Neuroscience Critical Care Division, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA. abhardwa@jhmi.edu
authors.forename: Anish
authors.initials: A
authors.lastname: Bhardwaj
authors.forename: Nabil J
authors.initials: NJ
authors.lastname: Alkayed
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Kirsch
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Hurn
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006348:Cardiac Surgical Procedures; D006323:Heart Arrest / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology