[Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats].
OBJECTIVE
To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I.


METHODS
Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also.


RESULTS
JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level.


CONCLUSIONS
JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.
Lin
Yan-ping
YP
Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou 350003.
Ma
Jian-hua
JH
Feng
Er-you
EY
D000818:Animals; D015519:Bone Density; D002116:Calcitonin / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D015675:Osteocalcin / Q000097:blood*; D010024:Osteoporosis / Q000097:blood / Q000517:prevention & control*; D010052:Ovariectomy; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D015675:Osteocalcin; D004958:Estradiol; D002116:Calcitonin