title: Renal cell carcinoma with intratumoral calcium oxalate crystal deposition in patients with acquired cystic disease of the kidney.
abstract: We describe 2 cases of renal cell carcinoma arising in acquired cystic disease of the kidney (ACDK) in patients with end-stage renal disease undergoing hemodialysis for more than 5 years and provide a brief review of the complications of ACDK. In both cases, abundant calcium oxalate crystals were observed within the tumors. Histologically, one of the tumors was a conventional (clear cell) renal cell carcinoma. The other tumor was a bilateral papillary renal cell carcinoma. Both tumors were high-grade carcinomas with extensive oncocytic (acidophilic) features. Also noted within the kidneys were cysts with atypical papillary hyperplasia. The clinicopathologic findings along with review of the literature suggest a relationship between tumor growth and calcium oxalate crystal deposition in patients undergoing hemodialysis with ACDK.
authors.affiliation: Department of Pathology and Urology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Rioux-Leclercq
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D002129:Calcium Oxalate / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000378:metabolism; D003460:Crystallization; D005260:Female; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000175:diagnosis*; D007676:Kidney Failure, Chronic / Q000628:therapy; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D002129:Calcium Oxalate