title: [Effect of Panax notoginseng saponins on human kidney fibroblast].
abstract: OBJECTIVE
  To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).
  
  
  METHODS
  KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.
  
  
  RESULTS
  Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.
  
  
  CONCLUSIONS
  PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.
authors.affiliation: Red-Cross Hospital of Yunnan, Kunming 650021.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Jun-ming
authors.initials: JM
authors.lastname: Fan
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Pan
mesh_terms: D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects*; D005355:Fibrosis / Q000517:prevention & control; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism; D007668:Kidney / Q000166:cytology* / Q000473:pathology; D005894:Panax / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology*
chemical_list: D024042:Collagen Type I; D019012:Integrin beta1; D012503:Saponins