Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy.
Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. The authors present the case of a 7-year-old boy with an abdominal mass diagnosed as IMT with malignant transformation. The tumor recurred twice after attempts at resection and was initially treated with vincristine and etoposide. After a third recurrence and incomplete resection, he was treated with cisplatin, Adriamycin, and methotrexate. He is disease-free after 2 years, representing successful combined surgery and chemotherapy in the treatment of malignant IMT. The use of chemotherapy for aggressive myofibroblastic tumors is reviewed.
Dishop
Megan K
MK
Department of Pathology, University of Kentuckey Children's Hospital/Chandler Medical Center, Lexington, USA.
Warner
Brad W
BW
Dehner
Louis P
LP
Kriss
Vesna M
VM
Greenwood
Martha F
MF
Geil
John D
JD
Moscow
Jeffrey A
JA
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic; D002648:Child; D006801:Humans; D007249:Inflammation; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery*; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome