title: Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse.
abstract: Senescence-accelerated mouse-prone (SAMP1; SAMP1@Umz) is an animal model of senile amyloidosis with apolipoprotein A-II (apoA-II) amyloid fibril (AApoAII) deposits. This study was undertaken to investigate the effects of dietary fats on AApoAII deposits in SAMP1 mice when purified diets containing 4% fat as butter, safflower oil, or fish oil were fed to male mice for 26 weeks. The serum HDL cholesterol was significantly lower (P < 0.01) in mice on the diet containing fish oil (7.4 +/- 3.0 mg/dl) than in mice on the butter diet (38.7 +/- 12.5 mg/dl), which in turn had significantly lower (P < 0.01) HDL levels than mice on the safflower oil diet (51.9 +/- 5.6 mg/dl). ApoA-II was also significantly lower (P < 0.01) in mice on the fish oil diet (7.6 +/- 2.7 mg/dl) than on the butter (26.9 +/- 7.3 mg/dl) or safflower oil (21.6 +/- 3.7 mg/dl) diets. The mice fed fish oil had a significantly greater ratio (P < 0.01) of apoA-I to apoA-II, and a smaller HDL particle size than those fed butter and safflower oil. Severe AApoAII deposits in the spleen, heart, skin, liver, and stomach were shown in the fish oil group compared with those in the butter and safflower oil groups (fish oil > butter > safflower oil group, P < 0.05). These findings suggest that dietary fats differ in their effects on serum lipoprotein metabolism, and that dietary lipids may modulate amyloid deposition in SAMP1 mice.
authors.affiliation: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan. umezawa@koshien.ac.jp
authors.forename: Makiko
authors.initials: M
authors.lastname: Umezawa
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Tatematsu
authors.forename: Tatsumi
authors.initials: T
authors.lastname: Korenaga
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Fu
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Matushita
authors.forename: Harumi
authors.initials: H
authors.lastname: Okuyama
authors.forename: Masanori
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Takeda
authors.forename: Keiichi
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D019588:Aging, Premature; D000686:Amyloidosis / Q000178:diet therapy / Q000517:prevention & control*; D000818:Animals; D016633:Apolipoprotein A-II / Q000187:drug effects / Q000378:metabolism*; D002079:Butter / Q000009:adverse effects; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D005395:Fish Oils / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism; D008297:Male; D051379:Mice; D058225:Plaque, Amyloid; D012450:Safflower Oil / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D016633:Apolipoprotein A-II; D004041:Dietary Fats; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D012450:Safflower Oil; D002079:Butter