[Effects of tea polyphenols on mice survival rate and white blood cell count after radiation].
In order to evaluate the anti-radiation effect of TPP (tea polyphenols), 60 female Kunming mice were chosen as group I for WBC (white blood cell) count, and another 60 female Kunming mice were set as group II for survival test. TPP was administrated orally to the mice. The results revealed that no significant difference was observed in the number of white blood cells in every test after the irradiation compared with that of the control group. Consequently, TPP showed no observably effect on the protection of the number of WBC against high dose irradiation. However, Mice survival rate of 0.83 ml/kg BW group and 25.0 ml/kg BW group are remarkably higher than that of the control group(P < 0.01). On the contrary, the control group had no survivor 30 days after the irradiation. This suggested that TPP can increase the survival rate evidently on mice after irradiation.
Ji
Rong
R
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Zhong
Kai
K
Li
Yepeng
Y
Li
Yanjun
Y
D000818:Animals; D004249:DNA Damage; D005419:Flavonoids; D005720:Gamma Rays; D007958:Leukocyte Count; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D011832:Radiation Injuries / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D015996:Survival Rate; D013662:Tea / Q000737:chemistry*; D014916:Whole-Body Irradiation
D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea