title: Myocardial angiogenesis resulting in functional communications with the left cavity induced by intramyocardial high-frequency ablation: histomorphology of immediate and long-term effects in pigs.
abstract: A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.
authors.affiliation: German Clinic for Diagnostics, Wiesbaden, Germany. dietz.kardio@dkd-weisbaden.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dietz
authors.forename: Georg
authors.initials: G
authors.lastname: Horstick
authors.forename: Tobias
authors.initials: T
authors.lastname: Manke
authors.forename: Mike
authors.initials: M
authors.lastname: Otto
authors.forename: Olaf
authors.initials: O
authors.lastname: Eick
authors.forename: C James
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: Jürgen
authors.initials: J
authors.lastname: Meyer
authors.forename: Harald
authors.initials: H
authors.lastname: Darius
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D003326:Coronary Circulation; D005240:Feasibility Studies; D017202:Myocardial Ischemia / Q000601:surgery*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D018919:Neovascularization, Physiologic; D013552:Swine