Dose-dependent effect of cholinotoxin AF64A on the cholinergic elements of the cingulum bundle in rat.
Previous studies revealed that cholinergic neurons possessing long axons are extremely sensitive to ethylcholine aziridinium ion (AF64A) administration [Neuropharmacology 31 (1992) 397]. In the present paper we examined the effect of AF64A on the cholinergic elements of the cingulum bundle. Seven days after AF64A administration choline acetyltransferase (ChAT)-immunoreactive fibers were extensively damaged on the dorsal part of cingulum bundle. These findings are the first reporting damage by AF64A to this brain region.
Dudas
Bertalan
B
Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Strich School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA. bdudas@lumc.edu
Rose
Michael
M
Hanin
Israel
I
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D002799:Cholinergic Fibers / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006179:Gyrus Cinguli / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014118:Toxins, Biological / Q000494:pharmacology*
D001388:Aziridines; D014118:Toxins, Biological; C044894:ethylcholine aziridinium; D002795:Choline O-Acetyltransferase; D002794:Choline