title: Ambient air quality and occurrence of multiple sclerosis relapse.
abstract: Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS relapse occurrence in south-western Finland were compared by multivariate logistic regression. The odds ratio of the risk of a relapse onset was over fourfold (4.143, p < 0.001) when the concentration of inhalable particulate matter (PM(10)) was at the highest quartile. Inhalable airborne particulate matter concentrations were connected to relapse occurrence. Poor air quality may enhance the seasonal changes in MS relapse occurrence by an increased susceptibility to transmissible infections.
authors.affiliation: Aerobiology Unit, University of Turku, Finland. mervi.oikonen@utu.fi
authors.forename: M
authors.initials: M
authors.lastname: Oikonen
authors.forename: M
authors.initials: M
authors.lastname: Laaksonen
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: O
authors.initials: O
authors.lastname: Oksaranta
authors.forename: E-M
authors.initials: EM
authors.lastname: Lilius
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
authors.forename: A
authors.initials: A
authors.lastname: Rantio-Lehtimäki
authors.forename: A
authors.initials: A
authors.lastname: Anttinen
authors.forename: K
authors.initials: K
authors.lastname: Koski
authors.forename: J-P
authors.initials: JP
authors.lastname: Erälinna
mesh_terms: D000397:Air Pollution / Q000009:adverse effects* / Q000706:statistics & numerical data*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology* / Q000209:etiology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D010316:Particle Size; D012008:Recurrence; D012189:Retrospective Studies; D012621:Seasons; D013997:Time Factors