Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study.
[reaction: see text] Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of alpha- or beta-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.
Peña
Diego
D
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Minnaard
Adriaan J
AJ
de Vries
André H M
AH
de Vries
Johannes G
JG
Feringa
Ben L
BL