title: Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease.
abstract: Neovascularization has recently been used as a new treatment for severe ischemic disease. We tried to induce therapeutic neovascularization by autologous bone marrow cell implantation (BMCI) in eight selected patients with chronic peripheral arterial disease (PAD), in whom traditional treatments had failed. Improvement of subjective symptoms was seen in seven patients after treatment. Of three limbs with toe or finger ulceration, complete healing was achieved in two, while the other one became less severe after treatment. No relative toxicity was observed in any of the patients. BMCI might be a feasible treatment for selected patients with chronic PAD.
authors.affiliation: Division of Cardiovascular Surgery, Department of Bioregulation, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, Japan 755-8505.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Esato
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Hamano
authors.forename: Tao-Sheng
authors.initials: TS
authors.lastname: Li
authors.forename: Akira
authors.initials: A
authors.lastname: Furutani
authors.forename: Atsushi
authors.initials: A
authors.lastname: Seyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takenaka
authors.forename: Nobuya
authors.initials: N
authors.lastname: Zempo
mesh_terms: D000368:Aged; D016026:Bone Marrow Transplantation; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D016491:Peripheral Vascular Diseases / Q000503:physiopathology* / Q000628:therapy*; D012881:Skin Temperature; D012883:Skin Ulcer / Q000503:physiopathology / Q000628:therapy; D013817:Thermography; D014034:Toes / Q000098:blood supply; D016896:Treatment Outcome