title: [Permeation of buspirone hydrochloride across animal buccal mucosa and its mechanism].
abstract: OBJECTIVE
  To study the permeation of busprione hydrochloride across animal buccal mucosa and its permeation mechanism.
  
  
  METHODS
  The in vitro penetration model was designed to investigate drug buccal mucosa permeability, and the influence factors (different animal oral mucosa, such as rabbit, guinea pig, pig, sheep and cow, drug concentrations and solution pH values) were measured.
  
  
  RESULTS
  The permeability of rabbit buccal mucosa for busprione hydrochloride was the largest. The permeation rate was increased with solution pH and directly to the drug concentration.
  
  
  CONCLUSIONS
  The transport way of busprione hydrochloride was passive diffusion and the transport channel was through cells.
authors.affiliation: Hebei Medical University, Shijiazhuang 050017, China. Du.qing@263.net
authors.forename: Q
authors.initials: Q
authors.lastname: Du
authors.forename: Q N
authors.initials: QN
authors.lastname: Ping
authors.forename: G
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002065:Buspirone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002417:Cattle; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009061:Mouth Mucosa / Q000378:metabolism*; D010539:Permeability; D011817:Rabbits; D012756:Sheep; D013552:Swine
chemical_list: D014151:Anti-Anxiety Agents; D002065:Buspirone