[Clinical observation on gastrointestinal protective effect of Composite Salviae injection in patients undergoing cardio-pulmonary bypass heart surgery].
OBJECTIVE
To observe the gastrointestinal protective effect of Composite Salviae Injection (CSI) in patients undergoing cardio-pulmonary bypass (CPB) heart surgery.


METHODS
Eighteen patients, who were scheduled to cardiac surgery (either atrial or ventrical septal repairing) undergoing CPB were randomized equally into two groups. Before CPB, the CSI group was treated with CSI 0.5 ml/kg by intravenous dripping and the control group was treated with normal saline in equal volume. The intragastric mucosa pH value (pHi) of patients was monitored by tensiometer.


RESULTS
As compared with the pre-CPB value, pHi lowered significantly during, 1 h and 2 hrs after CPB in the control group (P < 0.05 or P < 0.01), while in the CSI group, pHi lowered significantly only during CPB (P < 0.05), but with insignificant change at 1 h and 2 hrs after CPB. Comparison between the two groups showed that pHi value in the CSI group was higher significantly than that in the control group at all respective monitoring period (P < 0.05).


CONCLUSIONS
CSI has gastrointestinal protective effect in patients undergoing CPB cardiosurgery to some extent.
Zheng
L M
LM
Shenzhen Municipal Central Hospital, Guangdong 518036.
Liu
X L
XL
Xia
Z Y
ZY
D000293:Adolescent; D000975:Antioxidants / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D002648:Child; D004064:Digestive System / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000601:surgery; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010936:Plant Extracts; D020011:Protective Agents / Q000627:therapeutic use*; D027561:Salvia miltiorrhiza
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D020011:Protective Agents