Electroretinographic oscillatory potentials in different aged rats: an analysis in the domains of time and frequency.
OBJECTIVE
Electroretinographic Oscillatory Potentials (Ops) are considered to be the optimal parameter to study the retinal circulation disturbances the present we compared parameters of OPs between different aged rats under dark adaptation.


METHODS
The scotopic ERG were performed in anaesthetized rats aged 3, 12, 24 months. According a window of collective power spectrum field of the OPs was isolated by using the FFT and IFFT of the spectrum analysis program. The parameters in the time and frequency domains were calculated.


RESULTS
Results showed that the amplitudes of wavelets and the summed amplitudes of OPs declined with the increase of age. A reduction of the total power and dominated power of OPs was also found after the FFT. But implicit time of each OP and dominant frequency did not change obviously.


CONCLUSIONS
The present study indicated that change of OPs of rat might be related to senile degeneration of the retina and circulative deficiency in retina in elder rats.
Ye
H
H
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Liu
X
X
Tie
H
H
Sun
Y
Y
Li
P
P
D000375:Aging; D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography; D005583:Fourier Analysis; D008027:Light; D009991:Oscillometry; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000502:physiology*; D012162:Retinal Degeneration / Q000503:physiopathology; D012171:Retinal Vessels; D013997:Time Factors