title: Hodgkin's lymphoma and CD30 signal transduction.
abstract: Advances in molecular biology have shed light on the biological basis of Hodgkin's lymphoma (HL). Knowledge of the biological basis has enabled us to understand that most Hodgkin and Reed-Sternberg (H-RS) cells are derived from germinal center B-cells and constitutive nuclear factor kappaB (NF-kappaB) activation is a common molecular feature. Molecular mechanisms responsible for constitutive NF-kappaB activation, Epstein Barr virus latent membrane protein 1, and defective IkappaBalpha and IkappaB kinase activation have been clarified in the past several years. A recent study revealed the biological link between 2 characteristic features of H-RS cells: CD30 overexpression and constitutive NF-kappaB activation. Ligand-independent signaling by overexpressed CD3O was shown to be a common mechanism that induced constitutive NF-kappaB activation in these cells. These results suggest the self-growth-promoting potential of H-RS cells and redefine the biology of HL composed of H-RS cells and lymphocytes.
authors.affiliation: Fourth Department of Internal Medicine, Kitasato University, School of Medicine, Kanagawa, Japan. rhorie@med.kitasato-u.ac.jp
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Horie
authors.forename: Masaaki
authors.initials: M
authors.lastname: Higashihara
authors.forename: Toshiki
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D006689:Hodgkin Disease / Q000209:etiology* / Q000473:pathology; D006801:Humans; D017730:Ki-1 Antigen / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017730:Ki-1 Antigen; D016328:NF-kappa B