title: New, abridged pathway to Masamune's "southern hemisphere" intermediate for the total synthesis of bryostatin 7.
abstract: [reaction: see text] The "Southern Hemisphere" intermediate 2, used by Masamune and co-workers for their asymmetric total synthesis of bryostatin 7 (1), has been synthesized from (E)-1,4-hexadiene (11) by a 24-step pathway that has a longest linear sequence of only 20 steps. This is the shortest synthesis of 2 so far recorded, and moreover, it is fully stereocontrolled.
authors.affiliation: The Christopher Ingold Laboratories, The Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom. k.j.hale@ucl.ac.uk
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Hale
authors.forename: Mark
authors.initials: M
authors.lastname: Frigerio
authors.forename: Soraya
authors.initials: S
authors.lastname: Manaviazar
mesh_terms: D000475:Alkenes; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D054713:Bryostatins; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides; D009942:Organometallic Compounds
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; D009942:Organometallic Compounds; C475531:bryostatin 7; C046771:butyllithium; C046785:bryostatin 1