Lingual squamous cell carcinoma in a California sea lion (Zalophus californianus).
A 28-yr-old female California sea lion (Zalophus californianus) in a commercial aquarium developed an ulcerated lingual tumor and died. Necropsy revealed a moderately differentiated squamous cell carcinoma. Immunohistochemical staining and electron microscopic studies revealed that the tumor cells were strongly positive with anti-keratin-cytokeratin antibody and had abundant tonofibrils and desmosomes. The neoplasm had metastasized to a mandibular lymph node.
Sato
Tsuneo
T
Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.
Higuchi
Tomomi
T
Shibuya
Hisashi
H
Ohba
Shigeo
S
Nogami
Sadao
S
Shirai
Wataru
W
Watanabe
Hideaki
H
Honda
Shigeaki
S
D000818:Animals; D000836:Animals, Zoo; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008207:Lymphatic Metastasis; D046070:Sea Lions; D014062:Tongue Neoplasms / Q000473:pathology / Q000662:veterinary*