[Effect of losartan and amilodipine on the platelet activation and renal function in patients with mild and moderate hypertension].
OBJECTIVE
To evaluate the effect of losartan and amilodipine on the platelet activation and renal function, and to study the relationship between the platelet activation and hypertensive renal damage in patients with mild and moderate hypertension.


METHODS
Sixty patients with mild and moderate hypertension were divided into the losartan group and amilodipine group in a randomized and controlled method. Losartan or amilodipine was given for three months. The urinary albumin excretion rate (UAER), plasma alpha-granule membrane protein-140 (GMP-140), BUN, Bcr and creatinine clearance rate (CCR) were measured before and after the treatment.


RESULTS
1. The blood pressure, GMP-140 and UAER significantly decreased in the two groups after the treatment. 2. A positive correlation was found between the level of GMP-140 and that of UAER before or after the treatment in the patients with hypertension (r = 0.69, r = 0.48, P < 0.01), but no significant positive correlation was found between the decreased level of UAER and blood pressure after the treatment.


CONCLUSIONS
The blood pressure can be well controlled, and the renal function is improved after the treatment with losartan or amilodipine, of which the inhibition to the patelet activation may be responsible for the improvement of the renal function in patients with mild and moderate hypertension.
Xie
Xiu-mei
XM
Department of Geriatric Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Yu
Guo-long
GL
Zhou
Ping
P
D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects*
D000959:Antihypertensive Agents; D019007:P-Selectin; D017311:Amlodipine; D019808:Losartan