[Molecular mechanisms of environmental estrogens on reproductive and developmental toxicity].
It has been shown that numerous natural and synthetic chemicals with estrogenic activities are reproductive or developmental toxic factors in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity, however, are very complicated, especially the molecular mechanisms. This article introduced the current progress on molecular mechanisms of toxicity, which included modulating signaling pathways, interfering gene expression during embryo stage, inducing mutation, etc.
Long
Dingxin
D
School of Public Health, Peking University, Beijing 100083, China.
Li
Yong
Y
Chen
Feng
F
D000818:Animals; D001559:Benzhydryl Compounds; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000235:genetics; D004968:Estrogens, Non-Steroidal / Q000506:poisoning*; D005260:Female; D006801:Humans; D007529:Isoflavones; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D010636:Phenols / Q000506:poisoning*; D048789:Phytoestrogens; D028321:Plant Preparations; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D010636:Phenols; D048789:Phytoestrogens; D028321:Plant Preparations; C006780:bisphenol A; D000098826:Bisphenol A Compounds