The inheritance of hand osteoarthritis in Iceland.
OBJECTIVE
To assess the contribution of genetics to hand osteoarthritis (HOA) and its subsets in the Icelandic population.


METHODS
A list of 2,919 HOA patients, constituting 1% of the Icelandic population, was compiled through nationwide sources. This patient list was cross-referenced with a comprehensive Icelandic genealogy database, enabling the use of algorithms to assess familiality of HOA. Two methods were used: the average pairwise kinship coefficient (KC) of the patients, and the relative risk (RR) of HOA in relatives of patients. In each case, the results were compared with 1,000 control sets of similar composition with regard to number, age, and sex, generated from the genealogy database.


RESULTS
The KC for patients was significantly higher than for the control sets and was proportional to the degree of both interphalangeal (IP) and thumb base (first carpometacarpal [CMC] joint) involvement. The RR of HOA in sisters of women in the study was 2.0 (P < 0.001), while the RR in spouses was not significantly different from that in controls. The RR increased with the severity of the disease. Thus, sisters of women with severe IP HOA had an RR of 5.0 and sisters of those with severe first CMC involvement had an RR of 6.9. The increased risk also extended beyond the nuclear family, with significantly increased risk in cousins.


CONCLUSIONS
Patients seeking medical services for HOA are more related to each other than matched controls, supporting the role of a genetic component in the disease. The genetic influence in both IP and first CMC HOA appears to be similar and increases with increasing severity of the disease.
Jonsson
Helgi
H
Department of Rheumatology, Landspitalinn University Hospital, Reykjavik, Iceland. helgijon@rsp.is
Manolescu
Ileana
I
Stefansson
Stefan Einar
SE
Ingvarsson
Thorvaldur
T
Jonsson
Hjortur H
HH
Manolescu
Andrei
A
Gulcher
Jeff
J
Stefansson
Kari
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005190:Family; D005260:Female; D005789:Genealogy and Heraldry; D006225:Hand; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors