The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface.
Gordon
Dalia
D
Department of Plant Sciences, Tel-Aviv University, Ramat-Aviv, 69978, Tel Aviv, Israel. dgordon@post.tau.ac.il
Gurevitz
Michael
M
D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009498:Neurotoxins; D010455:Peptides / Q000145:classification / Q000235:genetics / Q000633:toxicity*; D017434:Protein Structure, Tertiary; D051381:Rats; D012604:Scorpion Venoms; D012605:Scorpions / Q000502:physiology*; D015222:Sodium Channels / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013499:Surface Properties; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D036341:Intercellular Signaling Peptides and Proteins; D009498:Neurotoxins; D010455:Peptides; D012604:Scorpion Venoms; D015222:Sodium Channels; C077585:leiurutoxin III; C029574:scorpion toxin receptor