[Effect of new zhengtian pill on expression of whole blood platelet membrane adhesion molecules in patients of migraine].
OBJECTIVE
To investigate the effect of New Zhengtian Pill (NZTP) on expression of whole blood platelet membrane adhesion molecules (PMAM) in patients of migraine.


METHODS
Sixty-eight patients were divided into two groups, the 35 patients in the treated group treated by NZTP orally and the 33 patients in the control group treated by Fuguiqin Capsule with a therapeutic course of 30 days for both groups. Changes of PMAM GP II b/III a(CD41) and P-selectin (CD62P) were observed by flow-cytometry and compared with those in healthy persons.


RESULTS
The markedly effective rate and total effective rate in the treated group was higher than those in the control group respectively (P < 0.05 and P < 0.01). The PMAM expression was also higher in patients, both at onset stage and intermittent stage, than in healthy persons (P < 0.01), NZTP treatment could reduce their increased expression significantly (P < 0.01).


CONCLUSIONS
NZTP could reduce the PMAM expression and inhibit the activation of platelet.
Zhu
C Q
CQ
Department of TCM, Nanfang Hospital, First Military Medical University, Guangzhou 510515.
Xie
W
W
Chan
B T
BT
D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000378:metabolism*; D019007:P-Selectin / Q000097:blood; D008517:Phytotherapy; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000096:biosynthesis*
D004365:Drugs, Chinese Herbal; D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex