[The expression of transforming growth factor alpha and its receptor in nasal polyps].
OBJECTIVE
To assess the possible role of expression of TGF alpha and EGFR in nasal polyps and its relationship with PCNA labeling index.


METHODS
Specimens from 20 patients of nasal polyps were studied with immunohistochemical technique.


RESULTS
The expression of TGF alpha, EGFR and PCNA were increased in the epithelium, gland cells and inflammatory cells of nasal polyps. There was a close correlation between the intensities of TGF alpha, EGFR and PCNA.


CONCLUSIONS
TGF alpha may play a key role in epithelial cell proliferation in nasal polyps.
Chen
F Q
FQ
Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Huang
W G
WG
Qiao
L
L
Jiang
H Y
HY
D000328:Adult; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen; D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors