title: Optimization of a beam shaping bolus for superficial microwave hyperthermia waveguide applicators using a finite element method.
abstract: Temperature inhomogeneity in hyperthermia treatments often limits the total thermal dose that can be delivered to the tumour region. To reduce such inhomogeneities, a prototype dynamically modifiable square array of saline-filled patches which attenuate microwave energy was developed for superficial treatments that use external microwave applicators. The array was situated inside the coupling water bolus that is often used with external applicators. The prototype has been previously tested clinically with promising results. A more complete theoretical analysis of the performance of this new bolus design and improvements to its design by modelling are presented here. The analysis was performed by performing five iterative simulations of the SAR pattern produced inside a tissue structure by a waveguide applicator with a water bolus containing the dynamic patch array attached. Between iterations the patch array configuration was modified in an attempt to improve the ability of the bolus to confine heating to an 'L'-shaped tumour region. These simulations were performed using the finite element method. The steady-state temperature profile was then computed using a finite element method based simulation of heat transfer that assumed a given applicator power level and water bolus temperature. Several iterations of these heat transfer simulations were performed with varying applicator power level and water bolus temperature to improve the confinement of heating to the target region. The analysis showed that the dynamic patch array should be capable of conforming heating to an 'L'-shaped target tumour region while limiting the heating to the surrounding normal tissue to an acceptable level.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. carl.kumaradas@utoronto.ca
authors.forename: J Carl
authors.initials: JC
authors.lastname: Kumaradas
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sherar
mesh_terms: D000273:Adipose Tissue / Q000528:radiation effects; D003198:Computer Simulation; D003972:Diathermy / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design / Q000379:methods; D019544:Equipment Failure Analysis / Q000379:methods; D020342:Finite Element Analysis; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods*; D008872:Microwaves / Q000627:therapeutic use*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000528:radiation effects; D009369:Neoplasms / Q000628:therapy; D011786:Quality Control; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012867:Skin / Q000528:radiation effects; D013696:Temperature