[Synthesis and biological activity of 2-[(substituted phenyl)vinyl] indole derivatives].
OBJECTIVE
To synthesize derivatives of 2-[substituted phenyl)vinyl] indole and find compounds with biological activities by screening in vitro.


METHODS
Twenty-one compounds of 2-[(substituted phenyl) vinyl] indole were synthesized by reduction, oxidation and Witting reaction. MS, 1HNMR and elemental analysis were used to determine the structures of the new compounds.


RESULTS
These compounds are new ones.


CONCLUSIONS
Six compounds (3, 9, 11, 13, 18 and 20) showed effects on some different receptors, such as alpha 2, D2 and H1, and is worth further studying.
Xu
L
L
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Xu
S P
SP
D000818:Animals; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000378:metabolism; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D007211:Indoles; D018341:Receptors, Adrenergic, alpha-2; D017448:Receptors, Dopamine D2; D011969:Receptors, Histamine H1; D014753:Vinyl Compounds