title: Altered myocardial flow reserve and endothelial function late after Kawasaki disease.
abstract: OBJECTIVE
  Coronary arterial lesions after Kawasaki disease (KD) may cause coronary endothelial dysfunction as the result of intimal hypertrophy. Our purpose was to assess myocardial flow reserve (MFR) and endothelial function in various myocardial regions after KD by using positron emission tomography.
  
  
  METHODS
  Twenty-seven patients, 17.2 +/- 3.2 years of age, who had KD at 1.9 +/- 1.4 years, and 12 normal healthy subjects, 26.5 +/- 3.4 years of age, were evaluated by means of myocardial blood flow (MBF) with (15)O-water positron emission tomography. MFR was estimated by MBF changes under adenosine triphosphate infusion and endothelial function by MBF changes under cold pressor testing. The left ventricle was divided into three coronary territories. Ten stenotic regions, 20 aneurysmal regions, 30 regressed aneurysmal regions, and 21 regions without coronary arterial lesions were compared with 36 control regions of the normal volunteers.
  
  
  RESULTS
  MBF at rest was similar in each region. Hyperemic blood flow and MFR in each region after KD was significantly lower than those in the regions of normal volunteers. MBF during cold pressor testing was significantly reduced in each region after KD, as compared with no change in the control regions.
  
  
  CONCLUSIONS
  Our study indicates impaired MFR and endothelial function regardless of coronary artery status after KD.
authors.affiliation: Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Furuyama
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Odagawa
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Iwado
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Noriyasu
authors.forename: Megumi
authors.initials: M
authors.lastname: Mabuchi
authors.forename: Keiichirou
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kuge
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000255:Adenosine Triphosphate; D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003080:Cold Temperature; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D005080:Exercise Test; D006801:Humans; D006984:Hypertrophy / Q000473:pathology / Q000503:physiopathology; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D012146:Rest; D013997:Time Factors; D014055:Tomography, Emission-Computed; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology*; D014655:Vascular Resistance; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D000255:Adenosine Triphosphate