[Using chengqi prescription to prevent hepatic ischemia/reperfusion injury after liver transplantation in rats].
OBJECTIVE
To study the effect of Chengqi prescription in preventing hepatic ischemia/reperfusion injury after liver transplantation in rats.


METHODS
Rat in situ liver transplantation model was used, donor liver was preserved in Ringer's solution for 4 hrs under 4 degrees C, then divided randomly into Chinese medicine group (Chengqi prescription), polymyxin B group, mannitol group, normal saline group and sham operation control group, each group further subdivided into two subgroups: 1 hr group and 4 hrs group after transplantation. The serum ALT and liver injury index was determined.


RESULTS
In preventing hepatic ischemia/reperfusion injury after liver transplantation, the Chengqi prescription was polymyxin B showed more effective than that of mannitol and normal saline, and the effect of Chengqi prescription was higher than that of polymyxin B (P < 0.05).


CONCLUSIONS
Chengqi prescription was effective in preventing hepatic ischemia/reperfusion injury after liver transplantation in rat.
Liang
F S
FS
Tianjin Third Central Hospital, Tianjin Medical University, Tianjin 300170.
Song
J C
JC
Gao
Y T
YT
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D016031:Liver Transplantation; D008297:Male; D008517:Phytotherapy; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
D004365:Drugs, Chinese Herbal