title: New stable backbone linker resins for solid-phase peptide synthesis.
abstract: [reaction: see text] Two new 4-methoxybenzaldehyde backbone linker resins were developed for the solid-phase synthesis of peptides. The linkers are very stable during the cleavage of common protecting groups for amines (Fmoc, Boc) and carboxylic acids (Me, All, tBu) in peptide synthesis. Cleavage from the resin with refluxing TFA is sufficiently mild for peptides containing polar and nonpolar amino acids.
authors.affiliation: Department of Chemistry and Drug Discovery Program, Northwestern University, Evanston, Illinois 60208-3113, USA.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Gu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Silverman
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D012117:Resins, Synthetic
chemical_list: D001547:Benzaldehydes; D003432:Cross-Linking Reagents; D010455:Peptides; D012117:Resins, Synthetic; C024896:4-anisaldehyde