title: Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12.
abstract: Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetic/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-alpha, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.
authors.affiliation: Divisions of Pathology and Laboratory Medicine, University of Milan School of Medicine, Italy. giancarlo.pruneri@ieo.it
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pruneri
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
authors.forename: Luca
authors.initials: L
authors.lastname: Baldini
authors.forename: Stefano
authors.initials: S
authors.lastname: Valentini
authors.forename: Maria
authors.initials: M
authors.lastname: Goldaniga
authors.forename: Davide
authors.initials: D
authors.lastname: Soligo
authors.forename: Nadia
authors.initials: N
authors.lastname: Carboni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lambertenghi-Deliliers
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000098:blood supply*; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008833:Microcirculation; D008875:Middle Aged; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D016898:Interferon-alpha