title: Genetic variability and transplantation.
abstract: OBJECTIVE
  The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications.
  
  
  RESULTS
  Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation.
  
  
  CONCLUSIONS
  These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.
authors.affiliation: Mount Sinai School of Medicine, New York, USA.
authors.forename: Brad
authors.initials: B
authors.lastname: Marder
authors.forename: Bernd
authors.initials: B
authors.lastname: Schröppel
authors.forename: Barbara
authors.initials: B
authors.lastname: Murphy
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines