Mechanisms of ischemic brain damage.
Neurologic complications from cerebral ischemia occur frequently following cardiac arrest, as well as in the perioperative period in cardiac surgery. The cellular and molecular mechanisms of cerebral ischemia are complex. This article discusses several important cell death and salvage pathways that are important in experimental cerebral ischemia that may be critical to outcome in clinical brain injury.
Bhardwaj
Anish
A
Meyer 8-140, Neuroscience Critical Care Division, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA. abhardwa@jhmi.edu
Alkayed
Nabil J
NJ
Kirsch
Jeffrey R
JR
Hurn
Patricia D
PD
D000818:Animals; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006348:Cardiac Surgical Procedures; D006323:Heart Arrest / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology