title: Nitroxyl radicals and malignant pigment melanoma.
abstract: Our studies showed that the spin-labeled (SL) compounds (free stable nitroxyl radical derivatives) accumulate predominantly in pigment melanoma and some of them possess high antimelanoma activity (100% curability of tumor bearing animals) and lower general toxicity. Taking into account our results we describe a proposed mechanism of the spin-labeled accumulation in melanoma, their antimelanoma activity and lower toxicity.
authors.affiliation: Department of Chemistry and Biochemistry, Thracian University, Stara Zagora, Bulgaria.
authors.forename: Zahari Dimitrov
authors.initials: ZD
authors.lastname: Raikov
authors.forename: Atanas Todorov
authors.initials: AT
authors.lastname: Atanasov
authors.forename: Elena Todorova
authors.initials: ET
authors.lastname: Raikova
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism*; D008956:Models, Chemical; D008962:Models, Theoretical; D009589:Nitrogen Oxides / Q000737:chemistry*; D009607:Nitrosourea Compounds / Q000737:chemistry; D010860:Pigments, Biological; D012825:Silicon / Q000737:chemistry; D013113:Spin Labels; D014226:Triazenes / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009589:Nitrogen Oxides; D009607:Nitrosourea Compounds; D010860:Pigments, Biological; D013113:Spin Labels; D014226:Triazenes; C039900:nitroxyl; D012825:Silicon