Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura.
The association between Helicobacter pylori ( H. pylori) infection and idiopathic thrombocytopenic purpura (ITP) has been reported by several groups. We investigated the prevalence of H. pylori infection and the effectiveness of its eradication in Japanese patients with ITP. H. pylori infection was found in 21 of 30 patients (70.0%) by (13)C urea breath test and presence of serum antibodies to H. pylori. H. pylori was eradicated in 18 of the 21 infected patients (85.7%) by administration of a proton pump inhibitor and two kinds of antibiotics. In only one patient was medication discontinued due to skin rash on the 4th day of treatment. Platelet recovery was obtained in ten patients (55.6%). In two patients with treatment failure, platelet recovery was obtained after successful re-eradication. In three patients without H. pylori infection, platelet counts did not significantly increase with the same treatment. On the other hand, eradication therapy did not affect platelet counts in patients with gastric ulcer. In conclusion, H. pylori eradication can be used for initial treatment with tolerable adverse effects in some ITP patients.
Hino
M
M
Department of Clinical Hematology and Clinical Diagnostics, Osaka City University, Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan. hinom@med.osaka-cu.ac.jp
Yamane
T
T
Park
K
K
Takubo
T
T
Ohta
K
K
Kitagawa
S
S
Higuchi
K
K
Arakawa
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications* / Q000628:therapy; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000382:microbiology; D010976:Platelet Count; D015995:Prevalence; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000382:microbiology*; D016896:Treatment Outcome