Michael addition of chloroalkyloxazolines to electron-poor alkenes: synthesis of heterosubstituted cyclopropanes.
Lithiated 2-(1-chloroethyl)-4,4-dimethyl-2-oxazoline 7 adds to electron-poor alkenyl heterocycles to afford substituted cyclopropanes in excellent yields. A route to chiral nonracemic heterosubstituted cyclopropanes, starting from optically active 2-chloromethyl-2-oxazolines, is highlighted as well.
Rocchetti
Maria Teresa
MT
Dipartimento Farmaco-Chimico, Università di Bari, Via E. Orabona 4, I-70125 Bari, Italy.
Fino
Vincenzo
V
Capriati
Vito
V
Florio
Saverio
S
Luisi
Renzo
R