title: Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice.
abstract: Calponin (h1 or basic) is an actin-binding protein that is expressed abundantly in smooth muscle. Our previous study using h1 calponin-null mutant mice demonstrated that h1 calponin inhibits the shortening velocity of smooth muscle contraction without significantly affecting the amplitude of force production. Furthermore, early onset of osteogenesis and increased bone formation have been reported in mutated mice. In the present study, we examined the effect of h1 calponin depletion on the metabolism and behavior of mice and found that the mutated mice showed increased locomotor activity, as well as increased intake of food and water, associated with the decreased number of neurons in the paraventricular nucleus of the hypothalamus (PVN).
authors.affiliation: Department of Veterinary Physiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Bannai
authors.forename: Ryo
authors.initials: R
authors.lastname: Yoshimoto
authors.forename: Minori
authors.initials: M
authors.lastname: MiTSUI-SAITO
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hori
authors.forename: Masugi
authors.initials: M
authors.lastname: Nishihara
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hisako
authors.initials: H
authors.lastname: Yamamura
authors.forename: Shun'ichiro
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Motoya
authors.initials: M
authors.lastname: Katsuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ozaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Karaki
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002452:Cell Count; D004327:Drinking Behavior; D005247:Feeding Behavior; D017353:Gene Deletion; D051379:Mice; D018345:Mice, Knockout; D008840:Microfilament Proteins; D009043:Motor Activity / Q000235:genetics*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology*; D013997:Time Factors; D000096985:Calponins
chemical_list: D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D000096985:Calponins