title: Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients.
abstract: The authors investigated whether patients with drug refractory epilepsy have cardiovascular abnormalities that might be related to a high frequency of sudden death. Twenty-three subjects underwent comprehensive cardiovascular evaluations before and during video-EEG monitoring. ST-segment depression occurred in 40% and was associated with a higher maximum heart rate during seizures. These data suggest that cardiac ischemia may occur in these patients.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. mona@akhphd.au.dk
authors.forename: S
authors.initials: S
authors.lastname: Tigaran
authors.forename: H
authors.initials: H
authors.lastname: Mølgaard
authors.forename: R
authors.initials: R
authors.lastname: McClelland
authors.forename: M
authors.initials: M
authors.lastname: Dam
authors.forename: A S
authors.initials: AS
authors.lastname: Jaffe
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004351:Drug Resistance; D004562:Electrocardiography; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006327:Heart Block / Q000175:diagnosis / Q000628:therapy; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis*; D011446:Prospective Studies; D012306:Risk; D012640:Seizures / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D014741:Video Recording