Nitroxyl radicals and malignant pigment melanoma.
Our studies showed that the spin-labeled (SL) compounds (free stable nitroxyl radical derivatives) accumulate predominantly in pigment melanoma and some of them possess high antimelanoma activity (100% curability of tumor bearing animals) and lower general toxicity. Taking into account our results we describe a proposed mechanism of the spin-labeled accumulation in melanoma, their antimelanoma activity and lower toxicity.
Raikov
Zahari Dimitrov
ZD
Department of Chemistry and Biochemistry, Thracian University, Stara Zagora, Bulgaria.
Atanasov
Atanas Todorov
AT
Raikova
Elena Todorova
ET
D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism*; D008956:Models, Chemical; D008962:Models, Theoretical; D009589:Nitrogen Oxides / Q000737:chemistry*; D009607:Nitrosourea Compounds / Q000737:chemistry; D010860:Pigments, Biological; D012825:Silicon / Q000737:chemistry; D013113:Spin Labels; D014226:Triazenes / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009589:Nitrogen Oxides; D009607:Nitrosourea Compounds; D010860:Pigments, Biological; D013113:Spin Labels; D014226:Triazenes; C039900:nitroxyl; D012825:Silicon