title: Efficacy of ozonized sunflower oil in the treatment of tinea pedis.
abstract: Ozonized sunflower oil, Oleozon, has a remarkable gerrmicidal action. In the present study, the efficacy of Oleozon in the treatment of tinea pedis was demonstrated in a controlled randomized phase III assay, comparing topical Oleozon with ketoconazole cream 2% (Nizoral) in 200 patients (100 in each group). The treatment administered was twice per day for a period of 6 weeks. The efficacy was evaluated clinically (disappearance of all lesions, with or without negative mycological results) and mycologically (negative culture results). A complete clinical and mycological cure was obtained in 75 and 81% for Oleozon and ketoconazole, respectively, with no significant differences between both groups. No side-effects or bacterial super-infections were observed. Patients were evaluated 6 months after the end of the treatment and no recurrence was observed in the Oleozon group. Oleozon can be an effective alternative low-cost antimycotic drug.
authors.affiliation: Centro de Investigaciones del Ozono, Apartado Postal 6880, Playa, Cuba. ozono@infomed.sld.cu
authors.forename: S
authors.initials: S
authors.lastname: Menéndez
authors.forename: L
authors.initials: L
authors.lastname: Falcón
authors.forename: D R
authors.initials: DR
authors.lastname: Simón
authors.forename: N
authors.initials: N
authors.lastname: Landa
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D004821:Epidermophyton / Q000187:drug effects; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010126:Ozone / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D000074242:Sunflower Oil; D014008:Tinea Pedis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D010938:Plant Oils; D000074242:Sunflower Oil; D010126:Ozone; D007654:Ketoconazole