Asymmetric total synthesis of the proposed structure of the medicinal alkaloid jamtine using the chiral base approach.
[reaction: see text] A highly step-economic asymmetric synthesis of the tetracyclic structure assigned to the medicinal alkaloid jamtine has been accomplished using a chiral lithium amide base desymmetrization of a ring-fused imide. The structure synthesized appears to be different from that of the natural product originally reported.
Simpkins
Nigel S
NS
School of Chemistry, University of Nottingham, Nottingham, United Kingdom. nigel.simpkins@nottingham.ac.uk
Gill
Christopher D
CD
D000470:Alkaloids / Q000138:chemical synthesis; D000588:Amines / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis*; D008094:Lithium; D008519:Medicine, Traditional; D010154:Pakistan; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D000588:Amines; D007094:Imides; D007546:Isoquinolines; C467072:jamtine; D008094:Lithium