[Effect of the tetrandrine on morphine induced hyperactivity and reinforcement in mice].
OBJECTIVE
After single administration of morphine and the motion activity was measured by ambulometer, conditioned place-preference paradigm was used to study the reinforcing effect of morphine, climbing behavior was used to evaluate the relation with Dopaminergic system and immediate early expression of c-fos gene was in brain was showed by immunohistochemical method.


RESULTS
Single administration of morphine could induce hyperactivity, repeated treatment would produce a conditioned place-preference response, tetrandrine 30 or 60 mg/kg hypodermic injection could inhibit the morphine induced hyperactivity, 60 mg/kg could inhibit the conditioned place-preference response but no influence on climbing behavior in mice was found. Tetrandrine could inhibit the c-fos gene expression in nucleus accumbens, ventral tegmental and prefrontal cortex in place-preference model formed by morphine.


CONCLUSIONS
Tetrandrine could inhibit the hyperactivity and conditioned place preference response induced by morphine, it might relate to reducing the c-fos gene expression in special area of brain in mice.
Zhu
Y
Y
Department of Pharmacology, Chongqing Medical University, Chongqing 400016.
Xue
C S
CS
Zhou
Q X
QX
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D001921:Brain / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression; D017781:Genes, Immediate-Early; D006948:Hyperkinesis / Q000139:chemically induced; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors*; D009043:Motor Activity / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics
D000470:Alkaloids; D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D016760:Proto-Oncogene Proteins c-fos; C009438:tetrandrine; D009020:Morphine