[The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients].
OBJECTIVE
To explore the correlation of clinical effect and TCRV beta 7 expression of He Jie Decoction (HJD) on chronic hepatitis B patients.


METHODS
45 patients of chronic hepatitis B were divided randomly into two groups. 30 patients in the treated group were treated by HJD, and 15 patients in the control group were treated by usual western medicine. The TCRV beta 7 level were detected before and after being treated.


RESULTS
After six months treatment, the ALT level of two groups were obviously decreased (P < 0.01), TCRV beta 7 expression were detected out in 6 patients of the treated group, and HBV-DNA and HBeAg of the 6 patients were negative conversion. The TCRV beta 7 expression couldn't be detected out in the control group, and HBV-DNA and HBeAg of the control group weren't negative conversion. There was no significant difference between the clinical total effective rate of the two groups (P > 0.05), but the apparent rate of the treated group was significantly higher than that of the control group (P < 0.01).


CONCLUSIONS
HJD might have the effect on improving the TCRV beta 7 expression of chronic hepatitis B patients, which might be the ways of HJD inhibiting and killing hepatitis B virus.
Zhang
Shijun
S
First Affiliated Hospital of Sun Yat-Sen Universty of Medical Sciences, Guangzhou 510080.
Cheng
Zexiong
Z
Huang
Bijun
B
Li
Junbiao
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D029972:Bupleurum / Q000737:chemistry; D004279:DNA, Viral / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D030021:Pinellia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis*; D031364:Scutellaria baicalensis / Q000737:chemistry
D000998:Antiviral Agents; D004279:DNA, Viral; D004365:Drugs, Chinese Herbal; D006513:Hepatitis B e Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta