Bombesin receptor subtype-3 modulates plasma insulin concentration.
Mice lacking a functional bombesin receptor subtype-3 (BRS-3) develop mild obesity. However, the origin of obesity in BRS-3 knockout (KO) mice remains unclear. We used a strain-crossing strategy to investigate the physiological role of the BRS-3 pathway. We crossed female heterozygous BRS-3 KO mice (X-/X) and male KK-Ay mice (Ay/+) to obtain BRS-3 KO/KK-Ay hybrid animals. In X-/Y:Ay/+ mice, plasma insulin concentrations were significantly higher, and on the oral glucose tolerance test, the additional secretion of insulin was impaired compared to other genotypes. Our results indicate that the BRS-3 pathway contributes to the regulation of plasma insulin concentrations.
Matsumoto
Kouji
K
Department of Pharmaceuticals Research Laboratory, Mitsubishi Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama-City, Kanagawa 227-0033, Japan. Matsumoto.Kouji@mk.m-pharma.co.jp
Yamada
Kazuyuki
K
Wada
Etsuko
E
Hasegawa
Takanori
T
Usui
Yoshihiro
Y
Wada
Keiji
K
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D003503:Cyclobutanes / Q000494:pharmacology; D004327:Drinking Behavior; D005247:Feeding Behavior; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D007328:Insulin / Q000502:physiology*; D008297:Male; D051379:Mice; D018004:Receptors, Bombesin / Q000502:physiology*
D001067:Appetite Depressants; D003503:Cyclobutanes; D007328:Insulin; D018004:Receptors, Bombesin; C107120:bombesin receptor subtype 3; C058254:sibutramine