title: Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
abstract: A case of Marchiafava-Bignami disease was serially evaluated with MR imaging and MR spectroscopy at 1, 2, 4, and 11 months after the onset of symptoms. The first MR imaging study showed extensive abnormal signal intensity of the corpus callosum without macroscopic changes; a diagnosis of Marchiafava-Bignami disease was made, and vitamin therapy was initiated. Follow-up studies showed progressive reduction of signal intensity abnormalities and residual callosal atrophy. MR spectroscopy revealed progressive reduction of the N-acetylaspartate:creatine ratio, with partial recovery in the last study, and a normalization of the choline:creatine ratio, which was initially slightly increased. Lactate was detectable during the subacute phase and was replaced by lipids after 4 months. This study confirmed the role of MR imaging in diagnosing Marchiafava-Bignami disease and particularly the value of MR spectroscopy in focusing the pathogenesis of the disease, monitoring its evolution and changes related to therapy.
authors.affiliation: Neuroradiology Department, Scientific Institute Ospedale San Raffaele, University Vita-Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Gambini
authors.forename: Andrea
authors.initials: A
authors.lastname: Falini
authors.forename: Lucia
authors.initials: L
authors.lastname: Moiola
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Comi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Scotti
mesh_terms: D019973:Alcohol-Related Disorders / Q000175:diagnosis*; D001284:Atrophy; D002794:Choline / Q000378:metabolism; D003337:Corpus Callosum / Q000473:pathology*; D003401:Creatine / Q000378:metabolism; D003711:Demyelinating Diseases / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D019344:Lactic Acid / Q000378:metabolism; D050356:Lipid Metabolism; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000175:diagnosis*
chemical_list: D019344:Lactic Acid; D003401:Creatine; D002794:Choline