Isoxazole --> benzisoxazole rearrangement promoted cascade reactions affording stereodefined polycycles.
[reaction: see text] A new chemo-, regio-, and stereoselective cascade reaction features a novel isoxazole --> benzisoxazole rearrangement and affords highly functionalized, differentially protected compounds. The products of this reaction are directly converted to a number of complex, structurally diverse polycyclic molecules. These transformations highlight the unique chemistry inherent to readily prepared fused isoxazoles.
Bode
Jeffrey W
JW
Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Uesuka
Hidehiro
H
Suzuki
Keisuke
K