[Research advances on bladder cancer associated genes].
Bladder cancer is the most common urinary tumors in China. Carcinogenesis of bladder is a multistep process. Accumulation of abnormal genotypes in a long period leads to malignant phenotypes. The genes associated with bladder carcinogenesis include oncogenes (such as H-ras, FGFR3, erbB2, CCND1, mdm2), tumor suppressor genes (such as INK4A/ARF, Rb, TP53, PTEN, TSC1, PTCH, DBCCR1), and DNA mismatch repair genes, etc. In this review, the authors discussed the recent research advances on the genes associated with bladder carcinoma.
Zhang
Rui
R
Department of Pathology, Chinese Academy of Medical Sciences, Beijing 100021, P. R. China.
Zhang
Jian-Jun
JJ
He
Zu-Gen
ZG
Cheng
Shu-Jun
SJ
Gao
Yan-Ning
YN
D020137:Base Pair Mismatch; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D051718:MutS Homolog 2 Protein; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein