[Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris].
OBJECTIVE
To investigate the effect of Tongxinluo capsule (TXLC) on the patients with unstable angina pectoris (UAP).


METHODS
Patients of UAP were divided into two groups, the treated group (n = 60) was treated with TXLC and the Danshen group (n = 30) was treated with composite Danshen tablet. The plasma endothelin (ET) and calcitonin gene related peptide (CGRP) were measured before and after treatment. Data were compared between the two groups and also compared with those measured in 20 healthy subjects for control.


RESULTS
ET level was higher and CGRP level lower significantly in UAP patients than that in healthy subjects significantly (P < 0.05). After TXLC treatment, ET significantly lowered (P < 0.01) and CGRP increased (P < 0.05). But in the Danshen group after treatment, the former decreased (P < 0.05), while the latter remained unchanged (P > 0.05). The effect of TXLC was better than that of composite Danshen tablet.


CONCLUSIONS
TXLC is an effective drug for UAP treatment, which could efficiently regulate the ET and CGRP metabolism and ameliorate the degree of myocardial ischemia damage.
Liang
Tie-jun
TJ
Shandong Provincial Hospital, Jinan 250021.
Zhang
Cai-qing
CQ
Zhang
Wei
W
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D015740:Calcitonin Gene-Related Peptide