title: Bullous SLE: response to methotrexate and relationship with disease activity.
abstract: We report on a case of 40-year-old female with systemic lupus erythematosus (SLE) who developed a severe bullous eruption on sun-exposed areas. The bullous manifestation was associated with a flare of lupus serologies, whereas the previous manifestations of the disease were quiescent. Due to prior intolerance to many drugs, she was given oral methotrexate (10 mg/week). The drug administration was followed by a rapid and full resolution of cutaneous lesions. Five months later she developed a class III lupus nephritis. Our case is the first report of efficacy of methotrexate in bullous SLE and rises the question of the relationship between bullous eruption and SLE activity.
authors.affiliation: Istituto di Clinica Medica Generale, Ematologia ed Inmunologia Clinica, Torrette di Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Malcangi
authors.forename: G
authors.initials: G
authors.lastname: Brandozzi
authors.forename: M
authors.initials: M
authors.lastname: Giangiacomi
authors.forename: M
authors.initials: M
authors.lastname: Zampetti
authors.forename: M G
authors.initials: MG
authors.lastname: Danieli
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000473:pathology; D008181:Lupus Nephritis / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate