The role of antileukotrienes in the treatment of asthma.
Cysteinyl leukotrienes (Cys-LTs) are mediators released in asthma and are both direct bronchoconstrictors and proinflammatory substances that mediated several steps in the pathophysiology of chronic asthma, including inflammatory cells recruitment, vascular leakage, and possibly airway remodelling. Available evidence from clinical trials and real world experience derived from managing patients with asthma justifies a broader role for antiLTRAs in asthma management than that recommended in the National Asthma Education and Prevention Programm (NAEPP) and National Health Lung and Blood Institute (NHLBI) treatment guidelines. Leukotriene-receptor antagonist drugs (LTRAs) seem to be effective alternatives to inhaled corticosteroids (ICS) either as monotherapy or as adjunctive therapy that reduces the need for higher doses of ICS in patients with mild-to-moderate persistent asthma. LTRAs may be used as adjunctive therapy for al levels of disease severity because they are effective in combination with ICS during long-term maintenance therapy. The agents seem especially effective in preventing aspirin-induced asthma, exercise-induced asthma (EIA) and they may provide an additional advantage of reducing nasal congestion in patients with both asthma and rhinitis.
Riccioni
G.
G
Respiratory Pathophysiology Center, Dept Internal Medicine, University of Chieti, School of Medicine, Chieti, Italy.
Santilli
F.
F
D'Orazio
N.
N
Sensi
S.
S
Spoltore
R.
R
De Benedictis
M.
M
Guagnano
M. T.
MT
Di Ilio
C.
C
Schiavone
C.
C
Ballone
E.
E
Della Vecchia
R.
R