title: Physiological responses of Carassius auratus to ytterbium exposure.
abstract: Physiological and biochemical perturbations in the liver of Carassius auratus were investigated in vivo following 40 days of exposure to ytterbium solutions of different concentration. Glutamate-pyruvate transaminase (GPT) activity in goldfish liver was stimulated at 0.05 mg/L Yb3+ and inhibited at higher Yb3+ concentrations. Activity of the antioxidant enzyme superoxide dismutase (SOD) was stimulated at Yb3+ higher than 0.05 mg/L, and catalase (CAT) activity was strongly inhibited after 40 days of exposure. Detoxifying enzymes glutathione S-transferase (GST) and glutathione peroxidase (GSH-Px) were stimulated at 0.05 mg/L and inhibited at 0.1 mg/L after 40 days of exposure. Among the parameters determined, CAT in goldfish liver was most sensitive to Yb3+, indicating that CAT might be considered a potential tool in the biomonitoring of exposure to Yb3+ in an aquatic ecosystem.
authors.affiliation: State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Guo
authors.initials: G
authors.lastname: Hongyan
authors.forename: Chen
authors.initials: C
authors.lastname: Liang
authors.forename: Wang
authors.initials: W
authors.lastname: Xiaorong
authors.forename: Chen
authors.initials: C
authors.lastname: Ying
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods*; D006054:Goldfish / Q000502:physiology*; D008099:Liver / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015018:Ytterbium / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D002374:Catalase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D015018:Ytterbium