title: Cissus sicyoides (princess vine) in the long-term treatment of streptozotocin-diabetic rats.
abstract: Leaf decoctions of Cissus sicyoides (princess vine) are taken widely as a popular remedy for diabetes mellitus in Brazil, where its common name is 'vegetal insulin'. However, there have been practically no attempts so far to determine scientifically whether it has anti-diabetic effects and we decided to administer leaf decoctions, over extended periods, to normal and streptozotocin-diabetic rats, and investigate the effects of this treatment on the physiological and metabolic parameters that are altered in diabetic animals. The experimental model adopted was shown to be appropriate by running a parallel treatment with insulin, which led to expected improvements in several abnormal parameter values. The decoction treatment significantly reduced the intake of both food and fluid and the volume of urine excreted, as well as the levels of blood glucose, urinary glucose and urinary urea, in comparison with controls. Lipid metabolism was not affected by the treatment; nor was the level of hepatic glycogen in diabetic animals, which indicated that the mechanism responsible for the improvement in carbohydrate metabolism, observed in animals treated with the decoction, could not involve inhibition of glycogenolysis and/or stimulation of glycogenesis. The fact that normal animals treated with C. sicyoides exhibited no changes in any of the measured parameters suggests that its mode of action in diabetic animals does not resemble those of sulphonylurea or insulin. It may, however, act in a similar way to biguanide, via inhibition of gluconeogenesis.
authors.affiliation: Departamento de Análises Cli;nicas, Faculdade de Ciências Farmacêuticas de Araraquara, Universidade Estadual Paulista Julio de Mesquita Filho, UNESP, Rua Expedicionários do Brasil n. 1621, Araraquara-CEP 14801-902-SP, Brazil. pepatomt@fcfar.unesp.br
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Pepato
authors.forename: Amanda Martins
authors.initials: AM
authors.lastname: Baviera
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: Vendramini
authors.forename: Maira da Penha Marques da Silva
authors.initials: Mda P
authors.lastname: Perez
authors.forename: Isis do Carmo
authors.initials: Ido C
authors.lastname: Kettelhut
authors.forename: Iguatemy Lourenço
authors.initials: IL
authors.lastname: Brunetti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D032422:Cissus / Q000737:chemistry* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005947:Glucose; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D007328:Insulin; D010936:Plant Extracts; D013311:Streptozocin; D005947:Glucose