[Study on effect of Salvia injection in treating primary nephrotic syndrome and on endothelin and serum interleukin-2 receptor in children].
OBJECTIVE
To explore the effect and mechanism of Salvia Injection (SI) in treating primary nephrotic syndrome (PNS) in children.


METHODS
Forty-four PNS children were randomly divided into conventional steroid treated group (20 cases) and conventional plus SI intervention treated group (24 cases), the levels of serum endothelin (ET), soluable interleukin-2 receptor (sIL-2R) were observed.


RESULTS
Before treatment, plasma ET and sIL-2R in PNS children were higher than those in healthy children significantly (P < 0.01). After treatment, the ET and sIL-2R levels were all obviously improved in both treated groups (P < 0.05) and the improvement in the conventional plus SI intervention treated group was more obvious, the difference between the two treated groups after treatment was significant (P < 0.05).


CONCLUSIONS
Conventional treatment supplemented with SI could more effectively improve the levels of plasma ET and SIL-2R in treating PNS children, and hence alleviate the damage of renal tissue.
Bao
Hua-ying
HY
Affiliated Nanjing Children Hospital of Nanjing Medical University, Nanjing 210008.
Yu
Hui-lan
HL
Wang
Lin
L
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D011241:Prednisone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D015375:Receptors, Interleukin-2; D011241:Prednisone