Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia.
OBJECTIVE
The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated.


METHODS
Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined.


RESULTS
Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level.


CONCLUSIONS
A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.
Ogura
Tosjio
T
Health and Medical Center, Okayama University, Okayama, Japan. oguogu@cc.okayama-u.ac.jp
Morita
Kiyoshi
K
Takeuchi
Mamoru
M
Otsuka
Fumio
F
Iwasaki
Tatsuo
T
Oe
Katsunori
K
Matsuura
Kazuharu
K
Tobe
Kazuo
K
Mimura
Yukari
Y
Kishida
Masayuki
M
Makino
Hirofumi
H
Hirakawa
Masahisa
M
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins / Q000652:urine*; D001127:Arginine Vasopressin / Q000097:blood*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D013997:Time Factors
C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D010455:Peptides; D001127:Arginine Vasopressin; D053607:Adrenomedullin; D003404:Creatinine