[Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction].
OBJECTIVE
To investigate the curative effect and therapeutical mechanism of composite salvia injection (CSI) in treating ischemic cerebral infarction in the respect of oxygen free radical and apolipoprotein.


METHODS
Sixty-eight cases of ischemic cerebral infarction within the first 72 hrs after onset were divided randomly into the CSI group (treated with CSI) and the control group (treated with Xueshuantong). Serum lipid peroxide (LPO) and superoxide dismutase (SOD) were measured by colorimetry and apolipoprotein A1 (ApoA1) and ApoB100 were measured with unidirectional immune diffusion method.


RESULTS
Serum levels of LPO and ApoB100 were obviously lower, and levels of SOD and ApoA1 significantly higher in the CSI group than those in the control group (P < 0.05 or P < 0.01). The total effective rate of CSI in treating cerebral infarction was 88.24%, which was significantly higher than that of the control (P < 0.05).


CONCLUSIONS
CSI shows definite effect in treating cerebral infarction, to reduce the oxygen free radical damage and regulate the apolipoprotein metabolism possibly was the important therapeutical mechanism.
Min
Lian-qiu
LQ
Department of Neurology, First Affiliated Hospital, Jinzhou Medical College, Liaoning 121001.
Dang
Li-ying
LY
Ma
Wei-yan
WY
D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D002544:Cerebral Infarction / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013482:Superoxide Dismutase / Q000097:blood
D016632:Apolipoprotein A-I; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D013482:Superoxide Dismutase