title: [Transformation of effusion and formation of granulation tissue in the pathologic process of otitis media with effusion].
abstract: OBJECTIVE
  To explore the transformation of stagnant effusion (SE) and the pathologic behavior leading to granulation tissue (GT) formation in the pathologic process of otitis media with effusion (OME).
  
  
  METHODS
  The temporoal bone slides from 306 ears with OME at the Otopathology Laboratory of the University of Minnesota USA were studied histopathologically under light microscopy.
  
  
  RESULTS
  The observations revealed a pathologic process in which the type and the condition of stagnant effusion in the middle ear cleft was variable in the dynamics of OME progression from an early pathologic stage to an advanced pathologic stage. The granulation tissue was primarily formed by two types of fibroblast proliferation in subepithelial space. The absorption and the orgnization of SE and the formation of granulation tissue maybe occur simultaneously in same areas and a same pathologic process.
  
  
  CONCLUSIONS
  The granulation tissue can only form in the areas where effusion has stagnated and has been absorpted. It is very important that effusion of the otitis media should be removed completly before the formation of granulation tissue.
authors.affiliation: Department of ENT, Second Clinical Medical College, Xi'an Medical University, 710004.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Liang
mesh_terms: D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D010034:Otitis Media with Effusion / Q000473:pathology*; D010035:Otitis Media, Suppurative / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology