title: Growing antimicrobial resistance of Shigella isolates.
abstract: Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991-1992, we identified a significantly increased resistance to tetracycline (from 23% to 87%, P < 0.00001), high resistance to trimethoprim-sulfamethoxazole (94%) and ampicillin (85%) and emerging resistance to quinolones (0.5-2%). These data mandate local monitoring of resistance and its consideration in empirical therapy.
authors.affiliation: Department of Paediatrics A, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202, Israel. ashai@post.tau.ac.il
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
authors.forename: Itzhak
authors.initials: I
authors.lastname: Levy
authors.forename: Vered
authors.initials: V
authors.lastname: Kazaronovski
authors.forename: Zmira
authors.initials: Z
authors.lastname: Samra
mesh_terms: D000328:Adult; D002648:Child; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D015995:Prevalence; D012760:Shigella / Q000187:drug effects*; D013997:Time Factors