title: Metastatic gastroesophageal junction adenocarcinoma to the extraocular muscles.
abstract: OBJECTIVE
  To present one definitive and one probable case of gastroesophageal adenocarcinoma metastases to the extraocular muscles.
  
  
  METHODS
  Two observational case reports.
  
  
  METHODS
  Two interventional case reports with clinical pathologic correlation and review of the literature. Vanderbilt University Institutional Review Board approval was obtained for this report.
  
  
  METHODS
  We analyzed the presenting symptoms, visual acuity, motility, and external examination.
  
  
  RESULTS
  Computed tomography showed nodular enlargement of an isolated rectus muscle. Histopathologic examination confirmed the diagnosis of metastatic gastrointestinal carcinoma in one case. The orbital neoplasm contained signet ring cells, classically seen in gastrointestinal malignancy.
  
  
  CONCLUSIONS
  Metastasis from gastrointestinal carcinoma should be considered in the differential diagnosis of a patient presenting with diplopia or visual loss, particularly with a recent history of gastrointestinal malignancy.
authors.affiliation: Vanderbilt University School of Medicine, Nashville, TN 37232-8808, USA.
authors.forename: Jaclyn M
authors.initials: JM
authors.lastname: Lekse
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Louise A
authors.initials: LA
authors.lastname: Mawn
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D000368:Aged; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000473:pathology*; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009801:Oculomotor Muscles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D014057:Tomography, X-Ray Computed