title: [Neonatal consequences of preterm premature rupture of membrane (PPROM) at 24-34 WG: 118 singleton pregnancies].
abstract: OBJECTIVE
  To evaluate the outcome of preterm infants born after preterm premature rupture of membranes (PPROM) between 24 and 34 weeks gestation (WG).
  
  
  METHODS
  One hundred and eighteen consecutive singleton infants were included in a prospective unicenter study during 3 years. A PPROM management had been instituted by the local obstetrician's board committee. In case of suspected chorioamniotitis defined by maternal or fetal criteria or in case of fetal heart rate abnormalities, a fetal extraction was decided. Diagnosis of chorioamnionitis was confirmed regarding the results of placenta culture and/or histology. Neonatal sepsis was defined by positive blood placenta culture or by the association of 2 positive bacterial cultures with a CRP>15 mg/l.
  
  
  RESULTS
  The mean gestational age was 29.8 WG (24-34 SA) for PPROM and 30.4 WG for delivery. Mean latency period between PPROM and delivery was 119 hours +/- 208. The incidence of choriamnionitis was 31%. The overall incidence of neonatal sepsis was 15%. Neonatal mortality was 11.7%. Bronchopulmonary dysplasia occured in 8.4% of the liveborn cases and cranial ultrasound abnormalities (HIV III-IV, kystic LPV) in 11.7% of overall cases. Cerebral lesions were positively correlated with hypotension and negatively correlated with GA. Cerebral lesions seemed to occur more frequently in case of chorioamnionitis but it is not significant.
  
  
  CONCLUSIONS
  In this study, in case of PPROM between 24-34 SA, gestational age and hypotension are correlated with neurologic injury.
authors.affiliation: Service de Néonatologie et de Pédiatrie, Hôpital Nord, Marseille. claire.nicaose@ap-hm.fr
authors.forename: C
authors.initials: C
authors.lastname: Nicaise
authors.forename: C
authors.initials: C
authors.lastname: Gire
authors.forename: P
authors.initials: P
authors.lastname: Fagianelli
authors.forename: R
authors.initials: R
authors.lastname: Debriere
authors.forename: L
authors.initials: L
authors.lastname: Thomachot
authors.forename: C
authors.initials: C
authors.lastname: d'Ercole
authors.forename: L
authors.initials: L
authors.lastname: Boubli
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D002821:Chorioamnionitis / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000175:diagnosis*; D005602:France / Q000453:epidemiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology