title: Circadian pattern of intragastric acidity in patients with non-erosive reflux disease (NERD).
abstract: BACKGROUND
  Most patients with gastro-oesophageal reflux disease have non-erosive reflux disease. Proton pump inhibitors are less effective than expected in these patients, but no previous study has measured their 24-h gastric pH values.
  
  
  OBJECTIVE
  To evaluate whether there are differences in 24-h intragastric acidity between reflux patients with and without oesophagitis and controls. The influence of Helicobacter pylori on the gastric pH of reflux patients was also assessed.
  
  
  METHODS
  Sixty-three consecutive patients with gastro-oesophageal reflux disease symptoms who agreed to undergo endoscopy and 24-h pH-metry were recruited. Twenty-five (39%) had erosive oesophagitis and 38 (61%) did not. H. pylori was diagnosed by CLO test, histology and 13C-urea breath test. Gastric pH was also measured in 30 controls without digestive symptoms.
  
  
  RESULTS
  H. pylori was found in seven of the 25 (28%) patients with oesophagitis and 14 of the 38 (37%) patients with non-erosive reflux disease. Oesophageal pH-metry was abnormal in 21 of the 25 (84%) patients with oesophagitis and in 32 of the 38 (84%) patients with non-erosive reflux disease. The median gastric pH did not differ between patients with and without oesophagitis or between them and controls during the 24 h (P = 0.8) and other time intervals (P = 0.2-0.4). The gastric pH did not differ between infected and non-infected patients with oesophagitis (P = 0.2-0.4) or non-erosive reflux disease (P = 0.3-0.8).
  
  
  CONCLUSIONS
  The circadian pattern of intragastric acidity does not differ between patients with non-erosive reflux disease and oesophagitis. Moreover, the study confirms that H. pylori infection does not affect the gastric pH in either group of reflux patients.
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zentilin
authors.forename: P
authors.initials: P
authors.lastname: Dulbecco
authors.forename: C
authors.initials: C
authors.lastname: Bilardi
authors.forename: C
authors.initials: C
authors.lastname: Gambaro
authors.forename: E
authors.initials: E
authors.lastname: Iiritano
authors.forename: R
authors.initials: R
authors.lastname: Biagini
authors.forename: G S
authors.initials: GS
authors.lastname: Mela
authors.forename: L
authors.initials: L
authors.lastname: Tessieri
authors.forename: M R
authors.initials: MR
authors.lastname: Mele
authors.forename: C
authors.initials: C
authors.lastname: Mansi
authors.forename: N
authors.initials: N
authors.lastname: Pandolfo
authors.forename: S
authors.initials: S
authors.lastname: Vigneri
authors.forename: V
authors.initials: V
authors.lastname: Savarino
mesh_terms: D001284:Atrophy; D002940:Circadian Rhythm; D004941:Esophagitis / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000473:pathology