[Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model in mice].
OBJECTIVE
To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and study its mechanism.


METHODS
MRL model mice were established by hypodermic inoculation with L7212 cells following intraperitoneal injection of cytoxan (CTX) 25 mg/kg 3 days later, and divided into the control group and FZKBG group. The changes of T-lymphocyte subsets, including CD3+, CD4+ and CD8+, and the survival time in model mice were observed.


RESULTS
Comparing with the control group, FZKBG could obviously increase both the percentage and absolute value of CD3+ and CD4+ lymphocytes and prolong the survival time of model mice, the prolongation rate being 29.6%-60.4%.


CONCLUSIONS
FZKBG could markedly prolong the survival time of MRL mice, its mechanism might be through elevating the immune function and inhibiting the leukemic cells in model mice.
Xu
Y G
YG
Xiyuan Hospital of China Academy of TCM, Beijing 100091.
Ma
R
R
Hu
N P
NP
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D051379:Mice; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000276:immunology
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal