title: The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK.
abstract: Genetic competence is a differentiation process initiated by Bacillus subtilis as a result of nutritional deprivation, and is controlled by a complex signal transduction cascade. The promoter of comK, encoding the competence transcription factor, is regulated by at least four different transcription factors: Rok, CodY, DegU and ComK itself. Genetic data have shown that comK expression is influenced by the transition state regulator AbrB as well. In this paper we show that AbrB binds specifically to the comK promoter and covers the RNA polymerase binding site, making it the fifth transcription factor regulating the activity of the comK promoter.
authors.affiliation: Department of Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands. leendert.hamoen@path.ox.ac.uk
authors.forename: Leendert W
authors.initials: LW
authors.lastname: Hamoen
authors.forename: Daisy
authors.initials: D
authors.lastname: Kausche
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Marahiel
authors.forename: Douwe
authors.initials: D
authors.lastname: van Sinderen
authors.forename: Gerard
authors.initials: G
authors.lastname: Venema
authors.forename: Pascale
authors.initials: P
authors.lastname: Serror
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D017930:Genes, Reporter; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C087449:comK protein, Bacillus subtilis