Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar.
It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms.
Ogata
Kazuhiro
K
Department of Biochemistry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. ogata@med.yokohama-cu.ac.jp
Sato
Ko
K
Tahirov
Tahir H
TH
Tahirov
Tahir
T
D001665:Binding Sites; D022762:CCAAT-Enhancer-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D050676:Core Binding Factor Alpha 2 Subunit; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb / Q000737:chemistry / Q000378:metabolism; D050656:Transcription Factor AP-2; D051742:Transcription Factor CHOP; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D014158:Transcription, Genetic
D022762:CCAAT-Enhancer-Binding Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D051742:Transcription Factor CHOP; D004247:DNA