[Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].
OBJECTIVE
To study the protective effect and mechanism of osthol on learning and memory impairment of mice with acute senile model induced by AlCl3.


METHODS
After s.c. AlCl3 60 mg.kg-1 for 7 d and i.p. osthol 15 and 7.5 mg.kg-1 for 12 d, using step-through test and step-down test, the effect of osthol on learning and memory was observed and the glutathione peroxidase (GSH-PX) activities in blood and superoxide dismutase (SOD) activities in plasma and cerebrum were measured.


RESULTS
Osthol 15 and 7.5 mg.kg-1 significantly improved the capability of memory and enhanced the activities of GSH-PX and SOD in AlCl3 treated mice.


CONCLUSIONS
Osthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl3. Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide.
Shen
Li-xia
LX
Department of Pharmacology, Zhangjiakou Medical College, Zhangjiakou 075000, China.
Jin
Le-qun
LQ
Zhang
Dan-shen
DS
Xue
Gui-ping
GP
D000210:Acute-Phase Reaction; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002712:Chlorides / Q000494:pharmacology*; D031048:Cnidium / Q000737:chemistry; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
D017607:Aluminum Compounds; D002712:Chlorides; D003374:Coumarins; D000077410:Aluminum Chloride; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C046627:osthol