[Clinical and experimental study of shuangcao tuihuang granule-1 in treating severe jaundice of acute icterohepatitis].
OBJECTIVE
To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism.


METHODS
Thirty-four patients with severe jaundice of acute icterohepatitis were treated with SCTH-1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored.


RESULTS
The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P < 0.05). Experimental study revealed that SCTH-1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (P < 0.05).


CONCLUSIONS
SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.
Lian
Y X
YX
Guangzhou 8th People's Hospital of Guangdong Province, Guangzhou 510060.
Long
X Y
XY
Wu
W F
WF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; C002038:galactal; D005690:Galactose