[Protective effect of paeonol on repeated cerebral ischemia in rats].
Protcective effect of paeonol was observed in the repeated cerebral ischemia-reperfusion model in rats. Paeonol (100, 50 mg/kg x 7 d i.p.) could inhibit the increase of Ca2+, the decrease of superoxide dimutase (SOD) activity and the content of malondialdehyde (MDA), improve Ca(2+)-ATPase activity in ischemia brain tissue. The results showed that paeonol could protect cerebral ischemia by inhibiting accumulation of Ca2+ and production of oxygen free radical.
Zhang
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G
China Pharmaceutical University, Nanjing 210009.
Yu
Z
Z
Zhao
H
H
D000098:Acetophenones / Q000008:administration & dosage / Q000494:pharmacology*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000098:Acetophenones; D004365:Drugs, Chinese Herbal; C013638:paeonol; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000251:Adenosine Triphosphatases