YY1 transcription factor down-regulates expression of CCR5, a major coreceptor for HIV-1.
Expression of CCR5, a major coreceptor for human immunodeficiency virus type 1 (HIV-1), is regulated by a number of transcription factors. Here we report that the YY1 transcription factor down-regulates CCR5 promoter activity and that overexpression of YY1 reduces cell surface CCR5 expression and infectibility by R5-HIV-1. Because YY1 also down-regulates promoter activities of CXCR4, another major coreceptor for HIV-1 and HIV-1 long terminal repeat, this transcription factor may play a critical role in the pathogenesis of HIV-1 disease.
Moriuchi
Masako
M
Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Moriuchi
Hiroyuki
H
D001483:Base Sequence; D017931:DNA Primers; D015536:Down-Regulation; D050981:Erythroid-Specific DNA-Binding Factors; D005434:Flow Cytometry; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D010957:Plasmids; D019713:Receptors, CCR5 / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*; D014162:Transfection; D014779:Virus Replication / Q000502:physiology*; D050986:YY1 Transcription Factor
D017931:DNA Primers; D050981:Erythroid-Specific DNA-Binding Factors; D019713:Receptors, CCR5; D014157:Transcription Factors; D050986:YY1 Transcription Factor; C494698:YY1 protein, human