title: Dose-dependent effect of cholinotoxin AF64A on the cholinergic elements of the cingulum bundle in rat.
abstract: Previous studies revealed that cholinergic neurons possessing long axons are extremely sensitive to ethylcholine aziridinium ion (AF64A) administration [Neuropharmacology 31 (1992) 397]. In the present paper we examined the effect of AF64A on the cholinergic elements of the cingulum bundle. Seven days after AF64A administration choline acetyltransferase (ChAT)-immunoreactive fibers were extensively damaged on the dorsal part of cingulum bundle. These findings are the first reporting damage by AF64A to this brain region.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Strich School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA. bdudas@lumc.edu
authors.forename: Bertalan
authors.initials: B
authors.lastname: Dudas
authors.forename: Michael
authors.initials: M
authors.lastname: Rose
authors.forename: Israel
authors.initials: I
authors.lastname: Hanin
mesh_terms: D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D002799:Cholinergic Fibers / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006179:Gyrus Cinguli / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014118:Toxins, Biological / Q000494:pharmacology*
chemical_list: D001388:Aziridines; D014118:Toxins, Biological; C044894:ethylcholine aziridinium; D002795:Choline O-Acetyltransferase; D002794:Choline