title: Ganglioglioma in the thalamus of a puppy.
abstract: A solitary brain mass of a 4-month-old miniature dachshund showing seizure-like neurological signs was examined histopathologically. At necropsy a white tumor mass, replacing the thalamus, approximately 1.5 cm in diameter, was found. There was cystic space filled with yellowish pale fluid in the central area of the tumor mass. Histopathological examination revealed that the mass consisted of irregularly arranged well-differentiated neuronal and glial cells, and multifocal mineral deposits. The neuronal cells had a large clear nucleus and various amount of Nissl substances in the cytoplasm. Some neural cells were bi-nucleated. Neither mitotic figures nor proliferating cell nuclear antigen (PCNA)-positive nuclei was found in the neuronal cells. Immunostaining for glial fibrillary acidic protein (GFAP) revealed diffuse proliferation of GFAP-positive glial cells and their processes, while these glial cells did not show apparent cellular atypism, mitotic activity, or PCNA-immunoreactivity. Accordingly, the present tumor was diagnosed as ganglioglioma, and hamartomatous histogenesis might be possible.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Endo
authors.forename: Chieko
authors.initials: C
authors.lastname: Kai
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tatewaki
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
authors.forename: Susumu
authors.initials: S
authors.lastname: Tateyama
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology* / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D018303:Ganglioglioma / Q000473:pathology* / Q000662:veterinary*; D008297:Male; D013788:Thalamus / Q000473:pathology*