On biologically conformal boost dose optimization.
A method is described that allows the inclusion of biological imaging data in the optimization of intensity-modulated radiotherapy to produce dose boosts that conform with target subvolumes of potentially reduced radiosensitivity. The biological image (e.g. PET, fMRI, etc) is transformed into a dose efficiency distribution using a piecewise linear calibration function with a prescribed maximum boost factor. Instead of dose alone, the cost function of the optimization algorithm depends on the product of the physical dose times dose efficiency. An example case of a base-of-tongue tumour which was imaged with the hypoxia tracer fluoro-misonidazole is presented, showing the excellent capability of IMRT to produce dose distributions that conform to spatially variable dose prescriptions.
Alber
M
M
Department of Medical Physics. University of Tübingen, Tübingen, Germany.
Paulsen
F
F
Eschmann
S M
SM
Machulla
H J
HJ
D000465:Algorithms; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011786:Quality Control; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D014055:Tomography, Emission-Computed / Q000379:methods; D014062:Tongue Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*
C031843:fluoromisonidazole; D008920:Misonidazole