title: Lipid composition of outer stratum corneum in hereditary palmoplantar keratodermas.
abstract: BACKGROUND
  The analysis of lipid composition of the outer stratum corneum is a promising approach to study the pathophysiology of inherited disorders of keratinization.
  
  
  OBJECTIVE
  The purpose of the study was the search for biochemical alterations of stratum corneum lipids in hereditary palmoplantar keratoderma (PPK).
  
  
  METHODS
  Using high-performance thin-layer chromatography, we performed an analysis of all major stratum corneum lipid classes in scales of 29 patients with 8 different types of hereditary PPK.
  
  
  RESULTS
  In comparison to the controls, slight differences in the lipid pattern were found in all keratodermas. Reduced amounts of total ceramides and increased levels of free fatty acids were noted in nearly all types.
  
  
  CONCLUSIONS
  The study indicates that the abnormal composition of stratum corneum lipids in PPK is probably not caused by genetic defects of the epidermal lipid metabolism, but it appears to represent an epiphenomenon of a disturbed cornification.
authors.affiliation: Department of Dermatology, TOMESA Clinics, Bad Salzschlirf, Germany. kuester@tomesa.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Küster
authors.forename: Bodo
authors.initials: B
authors.lastname: Melnik
authors.forename: Heiko
authors.initials: H
authors.lastname: Traupe
authors.forename: Henning
authors.initials: H
authors.lastname: Hamm
mesh_terms: D000293:Adolescent; D000328:Adult; D002518:Ceramides / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004817:Epidermis / Q000737:chemistry*; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000235:genetics / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010214:Papillon-Lefevre Disease / Q000378:metabolism
chemical_list: D002518:Ceramides; D005230:Fatty Acids, Nonesterified; D008055:Lipids