Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC(50) of 0.42, 0.38 and 0.22 microM, respectively.
Hegde
Vinod R
VR
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com
Puar
Mohindar S
MS
Dai
Ping
P
Patel
Mahesh
M
Gullo
Vincent P
VP
Chan
Tze-Ming
TM
Silver
Jack
J
Pramanik
Birendra N
BN
Jenh
Chung-Her
CH
D018122:B7-1 Antigen / Q000187:drug effects*; D001667:Binding, Competitive / Q000187:drug effects; D018106:CD28 Antigens / Q000187:drug effects*; D002733:Chlorophenols / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D018122:B7-1 Antigen; D018106:CD28 Antigens; D002733:Chlorophenols; D010455:Peptides; D010456:Peptides, Cyclic; C476380:SCH204698; C476382:SCH79235; C476381:SCH79236; C090485:chloropeptin I; C023490:complestatin