Waldenström macroglobulinemia with a novel der(8;17)(q10;q10).
We report the occurrence of an unbalanced whole-arm translocation of der(8;17)(q10;q10) in an 80-year-old female patient with Waldenström macroglobulinemia. To our knowledge, der(8;17)(q10;q10) has not been described in Waldenström macroglobulinemia. Although this cytogenetic abnormality has been reported in a number of solid tumors, a literature review suggests also a possible association with B-cell chronic lymphoproliferative disorders.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, Kowloon, SAR, Hong Kong, China. kfwong@ha.org.hk
D000368:Aged; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D014178:Translocation, Genetic / Q000235:genetics*; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*