title: Primary plasmacytoma arising in an endocervical polyp with detection of neoplastic cells on papanicolaou test. A case report and review of the literature.
abstract: Primary plasmacytomas of the female genital tract are extremely rare and present a substantial diagnostic challenge. Five cases morphologically representing plasmacytomas and localized to the uterine cervix have been reported previously; however, only 1 was shown to be monotypic for immunoglobulin light-chain expression. We report the case of a 37-year-old woman who had highly atypical plasma cells on her Papanicolaou test. A clinically detected endocervical polyp was removed and revealed a plasmacytoma, the diagnosis of which was substantiated by demonstrating monotypic lambda-light-chain restriction and a clonal immunoglobulin heavy-chain gene rearrangement. The cytologic and histopathologic findings of plasmacytomas of the uterine cervix are discussed, including the utility of immunophenotypic and molecular techniques to confirm the neoplastic diagnosis.
authors.affiliation: Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque 87131-5301, USA.
authors.forename: Edgar G
authors.initials: EG
authors.lastname: Fischer
authors.forename: Thèrése J
authors.initials: TJ
authors.lastname: Bocklage
authors.forename: Ian
authors.initials: I
authors.lastname: Rabinowitz
authors.forename: Harriet O
authors.initials: HO
authors.lastname: Smith
authors.forename: David S
authors.initials: DS
authors.lastname: Viswanatha
mesh_terms: D000328:Adult; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007150:Immunohistochemistry; D065006:Papanicolaou Test; D010954:Plasmacytoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011127:Polyps / Q000150:complications / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D014626:Vaginal Smears