title: Relapse of coccidioidomycosis despite immune reconstitution after fluconazole secondary prophylaxis in a patient with AIDS.
abstract: We report a case of relapse of coccidioidomycosis in an HIV-infected person who discontinued maintenance azole therapy following a response to antiretroviral therapy. This experience raises concern about the safety of withholding secondary prophylaxis for coccidioidomycosis in persons with HIV infection who have achieved immunological responses to antiretroviral therapy.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: G
authors.initials: G
authors.lastname: Mathew
authors.forename: M
authors.initials: M
authors.lastname: Smedema
authors.forename: L J
authors.initials: LJ
authors.lastname: Wheat
authors.forename: M
authors.initials: M
authors.lastname: Goldman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D028761:Withholding Treatment
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole