title: Physiological and psychological markers associated with HIV-related fatigue.
abstract: Fatigue is among the most common and debilitating complaints of HIV-positive individuals. These data are part of a larger exploratory study investigating the relationships of selected psychological and physiological factors among 40 participants with HIV-related fatigue. Fatigue severity was measured using the HIV-Related Fatigue Scale. Fatigue was correlated with depression (r = .40, p < .01), state anxiety (r = .40, p <.01), and trait anxiety (r = .46, p <.01). Of the physiological factors, there were three statistically significant correlations: thyroid-stimulating hormone was negatively correlated with fatigue severity (r = -.36, p = .02), and platelets (r = .35, p = .03) and alkaline phosphatase (r = .27, p = .09) were positively correlated with fatigue severity. There were no correlations between fatigue severity and CD4 count (r = -.16, p = .31) or fatigue severity and HIV viral load levels (r = .031, p = .84). Even among the group with excellent viral suppression, fatigue scores were still very high for many participants.
authors.affiliation: University of North Carolina School of Nursing, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Barroso
authors.forename: John R
authors.initials: JR
authors.lastname: Carlson
authors.forename: Janet
authors.initials: J
authors.lastname: Meynell
mesh_terms: D000328:Adult; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000097:blood* / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers