title: Two-year results after lumbar microdiscectomy with and without prophylaxis of a peridural fibrosis using Adcon-L.
abstract: BACKGROUND
  A retrospective study investigated the advantages of the intraoperative application of the anti-adhesion barrier gel Adcon-L after lumbar microdiscectomy.
  
  
  METHODS
  For the study, 92 patients were recruited. Following the operation, 46 patients (study group) received Adcon-L application. In other 46 patients (control group), wounds were closed without Adcon-L application. Median follow-up was 32 (range 26-33) months in the study group and 37 (range 32-41) months in the control group postoperation. All patients were examined clinically, and spinal MRIs were carried out on 12 randomly selected patients in each group.
  
  
  RESULTS
  According to the score of the Low Back Pain Committee of the Japanese Orthopedic Association, no significant clinical difference could be established between the two groups. Subjective evaluation of the operation results (score according to Weber) was not significant. Peridural scarring on the postoperative MRI of 24 patients did not differ significantly between the groups.
  
  
  CONCLUSIONS
  A significant effect on the clinical results after Adcon-L application could not be found.
authors.affiliation: Department of Orthopedics, Dietrich Bonhoeffer Klinikum Neubrandenburg, Pfaffenstr. 24, 17022 Neubrandenburg, Germany. GanzerD@Klinikum-NB.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Ganzer
authors.forename: Katrin
authors.initials: K
authors.lastname: Giese
authors.forename: Lutz
authors.initials: L
authors.lastname: Völker
authors.forename: Uwe
authors.initials: U
authors.lastname: Pietzner
authors.forename: Niels
authors.initials: N
authors.lastname: Follak
authors.forename: Harry
authors.initials: H
authors.lastname: Merk
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D017586:Diskectomy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005355:Fibrosis / Q000517:prevention & control*; D005500:Follow-Up Studies; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D009930:Organic Chemicals; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis; D011183:Postoperative Complications / Q000517:prevention & control; D011336:Probability; D020127:Recovery of Function; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: C104199:ADCON-L; D005782:Gels; D009930:Organic Chemicals