Relationship between plasma level of parathyroid hormone and carboxymethyllysine in hemodialyzed patients--does it exist?
OBJECTIVE
Both parathyroid hormone and advanced glycated end products (AGEs) are uremic toxins. The present study aimed to examine the likely interrelationship between these compounds.


METHODS
Seventy-four hemodialyzed patients (41 female, 33 male; mean age 47 +/- 2 years, mean duration on hemodialysis 36 +/- 6 months) were enrolled in this study. In all subjects, the body mass index (BMI) was calculated and total lean mass (TLM) and total fat mass (TFM) were assessed by dual X-ray absorptiometry. Blood samples for estimation of plasma calcium, phosphorus, carboxymethyl lysine (as marker of AGEs) and PTH-1-84 were obtained after overnight fasting, before subsequent hemodialysis session.


RESULTS
BMI, TFM and TLM were 23.6 +/- 0.5 kg/m2, 16.3 +/- 1.0 kg and 46.3 +/- 1.1 kg, respectively. PTH plasma level (223 +/- 32 pg/ml) and plasma CML (1,837 +/- 84 ng/ml) were markedly elevated as compared with reference values. A significant positive correlation was found between TLM and CML levels (tau = 0.225; p = 0.04) and between plasma PTH and CML levels (tau = 0.224; p = 0.04).


CONCLUSIONS
It seems likely that PTH and AGEs are interrelated. The pathophysiological relevance of this finding in the pathogenesis of uremic toxicity remains to be elucidated.
Kokot
F
F
Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University Medical School, Katowice, Poland. nefro@spskm.katowice.pl
Schinzel
R
R
Chudek
J
J
Heidland
A
A
Adamczak
M
M
Ficek
R
R
Wiecek
A
A
D015992:Body Mass Index; D002118:Calcium / Q000097:blood; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*
D017127:Glycation End Products, Advanced; D010281:Parathyroid Hormone; D010758:Phosphorus; C048496:N(6)-carboxymethyllysine; D008239:Lysine; D002118:Calcium