[Clinical and experimental study on anti-liver fibrosis effect of xuelong granule].
OBJECTIVE
To study the clinical effect and mechanism of Xuelong Granule (XLG) in antiliver fibrosis.


METHODS
Ninety-eight patients with liver cirrhosis were divided into 2 groups randomly. The 58 Patients in the treated group were treated by XLG and the 40 patients in the control group were treated by Shenchai Granule for 3 months. Levels of serum hyaluronic acid (HA) and laminin (LN), and pathological changes of liver tissues were observed before and after treatment. In experimental study on model rats, the liver tissue content of hydroxyproline and pathological changes under light and electron microscope were observed.


RESULTS
The total effective rate in the treated group was 72.4%, that in the control group was 40.0%, there was significant difference between the two groups (P < 0.01). The level of serum HA and LN in the treated group declined markedly after treatment, and pathological examination of 8 cases showed the fibrous tissues reduced obviously. Experimental study showed marked reduction of hydroxyproline content and significant lowering of fibrous tissue proliferation, both under light and electron microscope, in liver of model rats after XLG treatment.


CONCLUSIONS
XLG has a definite effect in anti-liver fibrosis.
Li
Z Z
ZZ
Jining Municipal Infectious Diseases Hospital, Shandong 272031.
Wang
X
X
Sui
Z Y
ZY
D000328:Adult; D000368:Aged; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000097:blood; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D006909:Hydroxyproline / Q000378:metabolism; D007797:Laminin / Q000097:blood; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D007797:Laminin; D006820:Hyaluronic Acid; D006909:Hydroxyproline