[Protective effect of total flavonoids of fructus choerospondiatis on adriamycin-induced rat cardiac peroxidation].
OBJECTIVE
To study the protection effect of total flavnoids of Fructus Choerospondiatis (TFFC) on rat cardiac muscle peroxidation in vitro and vivo.


METHODS
Adriamycin-induced peroxidation model on rat was adopted. Activities of LDH, AST and CK in rat's serum, activities of SOD, GSH-Px and content of MDA in rat cardiac muscle were determinated. Activity of LDH and content of MDA in cultured suckling rat cardiac cell were also determinated.


RESULTS
Compared with normal group, activities of LDH, AST, CK in serum and content of MDA in cardiac muscle on adriamycin group increased (P < 0.05, P < 0.001), activities of SOD, GSH-Px decreased in cardiac muscle (P < 0.001). Activity of LDH and content of MDA in cultured fluid of suckling rat cardiac cell were higher than that of normal group (P < 0.001). To various dosages TFFC groups, activity of LDH, AST, CK in serum and content of MDA in cardiac muscle decreased; activities of SOD and GSH-Px in cardiac muscle increased; activites of LDH and content of MDA in cultured fluid decreased (P < 0.01, P < 0.001).


CONCLUSIONS
TFFC can maintain the integrity of cytomembrane by scavenging free radicals and inhibiting lipid peroxidation, namely, TFFC has an effect of protecting cardiac muscle.
Zhang
X
X
Inner Mongolia Nationality University, Tongliao 028041.
Bao
B
B
Wang
Z
Z
Na
R
R
Sun
F
F
Li
B
B
D027926:Anacardiaceae; D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004317:Doxorubicin / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006335:Heart Injuries / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D016166:Free Radical Scavengers; D020011:Protective Agents; D008315:Malondialdehyde; D004317:Doxorubicin; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003402:Creatine Kinase