Molecular radio jamming: autoinducer analogs.
Synthesis of an N-acyl-homoserine lactone (N-acyl-HSL) analog library yields agonists and antagonists of the Pseudomonas aeruginosa quorum-sensing system. Active compounds also reveal heterogeneity in the lactone ring binding pockets of N-acyl-HSL-activated transcription factors.
Fast
Walter
W
Division of Medicinal Chemistry, College of Pharmacy and Graduate Programs in Biochemistry and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D025461:Feedback, Physiological / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000502:physiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D015534:Trans-Activators / Q000187:drug effects
D015534:Trans-Activators; C088386:homoserine lactone; D015107:4-Butyrolactone