Association study of the estrogen receptor polymorphisms with tardive dyskinesia in schizophrenia.
Tardive dyskinesia (TD) is an involuntary movement disorder induced by long-term antipsychotic treatments. Estrogen is suggested to modulate dopamine receptors in the central nervous system and may decrease the incidence and/or relieve the symptoms of TD. In this study, 118 schizophrenia patients with antipsychotic-induced TD and 128 sex- and age-matched non-TD schizophrenia patients were recruited. All patients were assessed by the Abnormal Involuntary Movement Scale and genotyped for the polymorphisms of estrogen receptor-alpha gene (ESR 1). There was a marginal association of the genotypes determined by PVU II between TD and non-TD patients (p = 0.057), but not of the genotypes determined by XBA I (p = 0.896). However, further studies on other polymorphisms of ESR 1 or other estrogen receptors are necessary to clarify the role of estrogen in the pathogenesis of TD.
Lai
I-Ching
IC
Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan, ROC. Hannah@love.url.com.tw
Liao
Ding-Lieh
DL
Bai
Ya-Mei
YM
Lin
Chao-Cheng
CC
Yu
Shun-Chieh
SC
Chen
Jen-Yeu
JY
Wang
Ying-Chieh
YC
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*; D012307:Risk Factors; D012494:Sampling Studies; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D011960:Receptors, Estrogen