Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.
Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
Nejentsev
Sergey
S
Department of Virology, University of Turku, Finland. serneje@gene.cimr.cam.ac.uk
Laaksonen
Mikko
M
Tienari
Pentti J
PJ
Fernandez
Oscar
O
Cordell
Heather
H
Ruutiainen
Juhani
J
Wikström
Juhani
J
Pastinen
Tomi
T
Kuokkanen
Satu
S
Hillert
Jan
J
Ilonen
Jorma
J
D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic
D018799:Intercellular Adhesion Molecule-1