Prenatal genetic testing by amniocentesis appears to result in a lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection.
OBJECTIVE
To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI).


METHODS
Retrospective analysis.


METHODS
Tertiary referral center.


METHODS
Eight hundred twenty-eight patients with singleton gestations achieved by ICSI.


METHODS
Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients).


METHODS
Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight.


RESULTS
A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 g (8.2% vs. 4.6%, respectively).


CONCLUSIONS
Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI.
Kolibianakis
Efstratios
E
Centre for Reproductive Medicine, University Hospital and Medical School, Dutch-Speaking Brussels Free University, Brussels, Belgium. stratis@easynet.be
Osmanagaoglu
Kaan
K
De Catte
Luc
L
Camus
Michel
M
Bonduelle
Maryse
M
Liebaers
Inge
I
Van Steirteghem
Andre
A
Devroey
Paul
P
D000022:Abortion, Spontaneous / Q000517:prevention & control*; D000328:Adult; D000649:Amniocentesis / Q000592:standards*; D015193:Chorionic Villi Sampling / Q000592:standards*; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure