Sustained hypoxia promotes hyperactive response of carotid body in the cat.
Carotid body chemosensory activities were measured before and after 0.2, 5,6 and 7 h of sustained isocapnic (PaCO(2) approximately equal to 30 Torr) hypoxia (PaO(2) approximately equal to 43 Torr) in the cats (n=7). The activity increased from 5.4 impsec(-1) at 0.2 h to about 13 impsec(-1) at 7 h. This increase in chemosensory activities were due to both an augmented sensitivity and to a long-term facilitation and not due to arterial [H(+)] changes.
Di Giulio
C
C
Department of Biomedical Sciences, School of Medicine, Chieti University, 66100 Chieti, Italy.
Huang
W X
WX
Mokashi
A
A
Roy
A
A
Cacchio
M
M
Macrì
M A
MA
Lahiri
S
S
D000818:Animals; D002344:Carotid Body / Q000378:metabolism*; D002415:Cats; D002628:Chemoreceptor Cells / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D008297:Male