Dynactin polices two-way organelle traffic.
How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes. This result suggests that dynactin may be a key player in coordinating vesicle traffic in this system.
Dell
Karen R
KR
kdell@itsa.ucsf.edu
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D000072159:Dynactin Complex; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D016547:Kinesins; D008547:Melanophores / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000378:metabolism
D002135:Calcium-Binding Proteins; D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D009124:Muscle Proteins; C499376:XKLP3 protein, Xenopus; D029867:Xenopus Proteins; C074152:kinesin-II; D016547:Kinesins