[The effects of perfluorodecalin on the anterior chamber angle and intraocular pressure in rabbits].
OBJECTIVE
To observe the effects of purfluorodecalin on the anterior chamber (AC) angle and intraocular pressure (IOP) in rabbits.


METHODS
0.05 ml perfluorodecalin was injected into right AC of 17 white rabbits and the same does of balanced salt solusion(BSS) was given to the controll group (6 rabbits). The IOP was measured before and 1, 2, 3, 4, 8, 12, 16 weeks after the injection. The treatment rabbits were sacrificed on the week of 1, 2, 4, 8 and 16 postoperatively. The eyes were enucleated and the histological examination was performed.


RESULTS
There's no statistic IOP difference in the controll group before and after the injection of BSS. In treatment group, the IOP is similar to the preoperation level (11.62 +/- 6.35 mmHg) on the 7th postoperative day (10.82 +/- 3.17 mmHg, P < 0.05). A increment of IOP was measured at the week of 2 to 4, 8, 12, and 16 postoperatively (P < 0.01). Perfluorodecalin, having a 'fish eggs' or bubbles appearance, was noted in the inferior AC. Histopathologically, transparent single or fused vesicles and macrophages were accumulated at the AC angler in treatment rabbits. Some lymphocytes and neutrophils were aslo noted here. Trabeculae degenerated and intertrabecular space increased.


CONCLUSIONS
The anterior chamber injection of perfluorodeclin could lead to a longstanding increase of IOP. Inflammatory reaction and trabeculae degeneration were seen in the anterior chamber angler.
Zhu
X
X
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Tang
S
S
Lu
F
F
Zhang
J
J
Zheng
H
H
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology / Q000633:toxicity*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009798:Ocular Hypertension / Q000139:chemically induced*; D011817:Rabbits; D011897:Random Allocation; D014129:Trabecular Meshwork / Q000473:pathology; D014822:Vitreous Body
D005466:Fluorocarbons; C008805:perfluorodecalin