[Effect of changtong oral liquids on the fibrinolytic activity of rabbits with experimental intestinal adhension].
OBJECTIVE
To observe the effect of Changtong Oral Liquid (CTOL) on the fibrinolytic activity of rabbits with experimental intestinal adhesion.


METHODS
Intestinal adhesion model of rabbits were made with reference to that described by Thomas and Rhoads and the animals were continuously orally supplemented with CTOL for seven days. Changes of tissue plasminogen activator (t-pA) and plasminogen activator inhibitor activity (PAI) as well as the intestinal adhesion were investigated.


RESULTS
Different dosage of CTOL produced protective effects on the postoperative intestinal adhesion accompanied by significant enhancement of t-PA activity and pronounced decreasement of PAI activity.


CONCLUSIONS
CTOL maybe play protective role in postoperative intestinal adhesion by modulating the activity of fibrinolytic system.
Li
Xiao
X
Department of Pharmacy, Nanfang Hospital, First Military Medical University, Guangzhou 510515.
Hou
Lianbing
L
Shan
Youliang
Y
Tong
Li
L
Chen
Yuyao
Y
D000818:Animals; D029745:Codonopsis / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000097:blood* / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D015849:Plasminogen Inactivators / Q000097:blood; D011817:Rabbits; D012250:Rheum / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D000267:Tissue Adhesions / Q000097:blood / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator