[Role of beta-adrenoceptor antagonists in the control of kindling models in rats].
OBJECTIVE
To study the role of beta-adrenoceptors (beta-AR) and their subtypes in the control of kindling models in rats.


METHODS
Electrical amygdala kindling, pentylenetetrazol (PTZ) kindling models in rats and maximal electroshock (MES) in mice were used to observe the effects of beta-AR agonists and antagonists.


RESULTS
The beta-AR antagonist propranolol 15 mg.kg-1 i.p. delayed the development of amygdala kindling; while propranolol 1-20 mg.kg-1 i.p. and beta-AR antagonist metoprolol 25-400 mg.kg-1 ig significantly increased the afterdischarge threshold and reduced the seizure severity in both kindling models (P < 0.01). beta 1-AR agonist dobutamine completely reversed the inhibitory effect of propranolol, while the beta 2-AR agonist terbutaline showed no effect on propranolol. Metoprolol 200 and 800 mg.kg-1 ig significantly inhibited MES in mice (P < 0.01).


CONCLUSIONS
Central beta 1-AR is involved in the inhibitory effects on amygdala kindling and PTZ kindling models in rats.
Yue
W
W
Department of Pharmacology, Medical School of Qingdao University, Qingdao 266021, China.
Zhang
F
F
Wang
L
L
Liu
Z T
ZT
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D014151:Anti-Anxiety Agents; D018342:Receptors, Adrenergic, beta-1; D011433:Propranolol; D008790:Metoprolol