[Lipoprotein(a) and Apo-A isoforms in patients with intermittent claudication].
OBJECTIVE
To study a correlation between lipoprotein(a) [LP(a)], as well as the phenotype of apoprotein(a) [apo(a)] and the presence of intermittent claudication (IC).


METHODS
The study included 25 patients (9 females, 16 males; mean age, 63.4 +/- 8.2 years) and 50 individuals (21 females, 29 males; mean age, 61.3 +/- 6.1 years) of a control group.


RESULTS
In the patients, the level of LP(a) was 3 times higher than in the controls (median 39 and 13 mg/dl, respectively; p < 0.01). The low molecular-weight phenotypes of apo(a) occurred significantly more frequently in the patients than those in the controls (62 and 28%, respectively; p = 0.02).


CONCLUSIONS
Multifactorial analysis has shown that the level of Lp(a) is an independent and important factor associated with the presence of IC.
Britareva
V V
VV
Afanas'eva
O I
OI
Dobrovol'skiĭ
A B
AB
Ezhov
M V
MV
Titaeva
E V
EV
Karpov
Iu A
IuA
Pokrovskiĭ
S N
SN
D000368:Aged; D001054:Apolipoproteins A / Q000097:blood* / Q000235:genetics; D001161:Arteriosclerosis / Q000097:blood; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood* / Q000209:etiology; D017270:Lipoprotein(a) / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010641:Phenotype
D001054:Apolipoproteins A; D017270:Lipoprotein(a)