[Animal model of immunologic change detection in vivo after xenotransplantation].
OBJECTIVE
To review the current condition, test method and progress of the animal model of xeno-graft-versus-host disease(xeno-GVHD).


METHODS
The literature review and comprehensive analysis methods were used in this article.


RESULTS
Implanted immunologic cells, the recepient had the chance of showing host-versus-graft reaction, GVHD or microchimerism. Now, xeno-GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways.


CONCLUSIONS
Chimeric cells is very important to xeno-GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation.
Zhang
Hai-tao
HT
Laboratory of Transplant Engineering and Transplant Immunology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041.
Li
You-ping
YP
D000818:Animals; D017690:Cell Transplantation; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000276:immunology*; D006648:Histocompatibility; D051379:Mice; D018183:Transplantation Chimera; D014183:Transplantation, Heterologous / Q000276:immunology*