title: Cerebrovascular disease in Italy and Europe: it is necessary to prevent a 'pandemia'.
abstract: In Italy and Europe, strokes are the third most common cause of death and resulting invalidity. In the ever-increasing 80-years-old-and-over population, strokes become more serious due to the clinical presentation during the acute phase and the ten times higher mortality, but also in relation to the twice as high resulting disability as for younger subjects. With the growing number of ailing and not-self-sufficient elderly, other resources will have to be relocated to this field of public health. Then, the dependence index and the ensuing equivalence based on estimates for the first decades of 2000 will create more difficulties in retrieving the funds for social policies. However, stroke prevention is possible both through correct behavioural habits and pharmacological means. Besides the well-known preventive effects of an adequate antihypertensive, antidiabetic and/or antiaggregant/anticoagulant therapy, there is increasing evidence of the effectiveness of statin therapy in stroke prevention. Subjects with a personal history of cerebrovascular events have an increased coronary risk and vice versa. The greatest part of the risk factors for the cerebrovascular disease coincides with those for cardiovascular disease, for which the correction of the former automatically involves a reduction in incidence of both pathologies. In this context, a statin's rational use can therefore represent an important tool for the combined prevention of the two pathologies. Finally, different hypotheses link the origin of Alzheimer's disease to that of progressive cerebrovascular dementia caused by cerebral microcirculation damage. The aim of this review is to resume the actual knowledge about the epidemiology of cerebrovascular disease in Italy and Europe, and about the means available to prevent this phenomenon.
authors.affiliation: Atherosclerosis and Dysmetabolic Disease Study Centre G. Descovich, University of Bologna, Bologna, Italy. gaddiats@med.unibo.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Gaddi
authors.forename: Arrigo  F G
authors.initials: A
authors.lastname: Cicero
authors.forename: Simona
authors.initials: S
authors.lastname: Nascetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Poli
authors.forename: Domenico
authors.initials: D
authors.lastname: Inzitari
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000517:prevention & control; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001521:Behavior Therapy; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000517:prevention & control*; D019353:Endemic Diseases / Q000517:prevention & control; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents