[Effects of nao-yi-an granule on the expression of heme oxygenase-1 in brains of intracerebral hemorrhagic rats].
OBJECTIVE
To investigate the effects of the traditional Chinese medicine complex nao-yi-an granule(NYA) on the expression of heme oxygenase-1(HO-1) in the brains of intracerebral hemorrhagic (ICH) rats.


METHODS
After inducing ICH rat models with collagenase VII, we used the immunohistochemical method and HO-1 immunoreactive cell count to observe the HO-1 expression.


RESULTS
Following ICH, the expression of HO-1 in the rat brains was observed at 12 h, peaking at 2 d and persisting until 7 d; and NYA could increase the expression at 24 h obviously.


CONCLUSIONS
Expression of HO-1 increases following ICH,; upregulation of HO-1 expression may be one of the neuroprotective mechanisms of NYA.
Tang
Tao
T
Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Luo
Tuan-lian
TL
Li
Xing-qun
XQ
D000818:Animals; D001921:Brain / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D051547:Heme Oxygenase-1; D020300:Intracranial Hemorrhages / Q000201:enzymology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1