Clinical utility of urinary antigen detection for diagnosis of community-acquired, travel-associated, and nosocomial legionnaires' disease.
The clinical utility of Legionella urinary antigen assays for the diagnosis of Legionnaires' disease was assessed by using samples from 317 culture-proven cases. The sensitivities of the Binax enzyme immunoassay (EIA) and Biotest EIA were found to be 93.7 and 94.4% for travel-associated infection and 86.5 and 76.0% for community-acquired infection but only 44.2 and 45.7% for nosocomially acquired infection, respectively.
Helbig
Jürgen H
JH
Institut Medizinische Mikrobiologie und Hygiene, Medizinische Fakultät TU Dresden, Dresden, Germany. Juergen.Helbig@mailbox.tu-dresden.de
Uldum
Søren A
SA
Bernander
Sverker
S
Lück
Paul Christian
PC
Wewalka
Günther
G
Abraham
Bill
B
Gaia
Valeria
V
Harrison
Timothy G
TG
D000942:Antigens, Bacterial / Q000652:urine*; D017714:Community-Acquired Infections / Q000175:diagnosis*; D003428:Cross Infection / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007877:Legionnaires' Disease / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D014195:Travel
D000942:Antigens, Bacterial