title: Extensive cutaneous metastasis of transitional cell carcinoma of the bladder.
abstract: Cutaneous metastasis of bladder carcinoma is extremely rare. Iatrogenic implantations have been the main cause in the majority of cases of transitional cell carcinoma with cutaneous metastasis. Otherwise, primary cutaneous metastasis is accepted as the late manifestation of systemic spread. The present paper describes a case of relatively early and extensive skin metastasis of transitional cell carcinoma in a 78-year-old man. The patient had a histopathological diagnosis of poorly differentiated (grade III) muscle invasive transitional cell carcinoma with a staging of T2NOMO 6 months prior to presenting. He presented to our outpatient clinic with a 3-month history of skin lesions as multiple, rubbery subcutaneous nodules. Radiological reinvestigation revealed no other metastatic site (including bone and lung), except for a metastatic nodule in the liver. The present paper reports an interesting and rare case of extensive skin metastasis of transitional cell carcinoma as the primary complaint.
authors.affiliation: Department of Urology, Abant Izzet Baysal University, School of Medicine, Duzce, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Akman
authors.forename: Kamil
authors.initials: K
authors.lastname: Cam
authors.forename: Ayse
authors.initials: A
authors.lastname: Kavak
authors.forename: Murat
authors.initials: M
authors.lastname: Alper
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001707:Biopsy, Needle; D016190:Carboplatin / Q000008:administration & dosage; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D016312:Treatment Refusal; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D016190:Carboplatin; D000093542:Gemcitabine