title: The role of innate immunity in the pathogenesis of acne.
abstract: Acne is a multifactorial disease of the pilosebaceous follicle. The most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. The pilosebaceous unit is an immunocompetent organ. Keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate and adaptive immune responses. The elements of the skin immune system are involved in the development of both noninflammatory and inflammatory acne lesions.
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Hungary. koreck@derma.szote.u-szeged.hu
authors.forename: A
authors.initials: A
authors.lastname: Koreck
authors.forename: A
authors.initials: A
authors.lastname: Pivarcsi
authors.forename: A
authors.initials: A
authors.lastname: Dobozy
authors.forename: L
authors.initials: L
authors.lastname: Kemény
mesh_terms: D000152:Acne Vulgaris / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D018949:Antigens, CD1 / Q000276:immunology; D055610:Antigens, CD1d; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology; D015603:Keratinocytes / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D051193:Toll-Like Receptors
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D029721:Drosophila Proteins; D018836:Inflammation Mediators; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors