Better chemistry for better survival, through regulation.
In this issue of Cell, report on new aspects of the regulation of yeast ribonucleotide reductase, the mechanism by which dNTP levels are increased following DNA damage, and the consequences of the metabolic changes.
Cox
Michael M
MM
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
D000818:Animals; D002470:Cell Survival / Q000235:genetics; D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D005057:Eukaryotic Cells / Q000201:enzymology*; D015966:Gene Expression Regulation, Fungal / Q000235:genetics; D006801:Humans; D012264:Ribonucleotide Reductases / Q000235:genetics*; D015003:Yeasts / Q000201:enzymology* / Q000235:genetics
D004247:DNA; D012264:Ribonucleotide Reductases