title: [Human parasite antigen-specific IFN-gamma response in schistosomitsis japonica endemic area].
abstract: OBJECTIVE
  To explore the characteristics of human schistosome antigen-specific IFN-gamma response in a population in an area endemic for schistosomiasis japonica.
  
  
  METHODS
  Three neighboring villages were chosen on Nanshan Island of Poyang Lake. 65 egg-negative persons and 64 egg-positive ones were selected randomly from the residents aged 14-41 years according to the egg counts by Kato-Katz thick smear method. IFN-gamma was measured in the whole blood culture supernatant after stimulated by the schistosome soluble egg antigen (SEA) and soluble worm antigen preparations (SWAP). Serum isotype-restricted antibody was detected by ELISA.
  
  
  RESULTS
  IFN-gamma levels induced by both SEA and SWAP were increased significantly after praziquantel treatment. The SEA-specific IFN-gamma level of the uninfected group was much higher than that of the reinfected group. A negative correlation between IFN-gamma level and IgG4 production was found, reflecting that IFN-gamma might be associated with the resistance to schistosome reinfection.
  
  
  CONCLUSIONS
  The changes in IFN-gamma level might play an important role in association with the resistance to schistosome reinfection.
authors.affiliation: Molecular and Immunoparasitology Research Department, Nanjing Medical University, Nanjing 210029.
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.forename: H W
authors.initials: HW
authors.lastname: Wu
authors.forename: Z S
authors.initials: ZS
authors.lastname: Zhang
authors.forename: R E
authors.initials: RE
authors.lastname: Weir
authors.forename: Z W
authors.initials: ZW
authors.lastname: Xie
authors.forename: L S
authors.initials: LS
authors.lastname: Hu
authors.forename: S Z
authors.initials: SZ
authors.lastname: Chen
authors.forename: M G
authors.initials: MG
authors.lastname: Taylor
authors.forename: G L
authors.initials: GL
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000918:Antibody Specificity; D000947:Antigens, Helminth / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D012008:Recurrence; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007371:Interferon-gamma