Molecular action of androgens.
The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: expression in the cells, ligand binding and DNA-specific sequence recognition by structurally conserved domains and regulation by transcriptional factors in an integrated response. We propose, here, an overview of recent works on the molecular regulation of androgen-dependent genes by AR.
Gobinet
J
J
INSERM U 439, Pathologie Moléculaire des Récepteurs Nucléaires, 70 Rue de Navacelles, 34090 Montepellier, France.
Poujol
N
N
Sultan
Ch
Ch
D000728:Androgens / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D041321:Chromosomes, Human, X; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011944:Receptors, Androgen / Q000737:chemistry / Q000378:metabolism*; D015533:Transcriptional Activation
D000728:Androgens; D008024:Ligands; D011944:Receptors, Androgen