[Clinical study on treatment of liver fibrosis in patients of hepatitis B by kangxian baogan decoction].
OBJECTIVE
To explore the clinical effect and therapeutic mechanism of Kangxian Baogan Decoction (KXBGD) on liver fibrosis caused by chronic hepatitis B.


METHODS
Eight-one patients with chronic hepatitis B were divided into two groups randomly. The 54 patients in the treated group were treated by KXBGD and the 27 patients in the control group were treated by conventional liver protecting treatment. Serum levels of hyaluronic acid (HA), procollagen type III (PC III), collagen type IV (C-IV), laminin (LN), transforming growth factor beta 1 (TGF beta 1) and tumor necrosis factor-alpha (TNF-alpha) were measured before and after treatment, meanwhile, liver function and pathological changes of liver tissues were observed.


RESULTS
The total effective rate in the treated group was significantly higher than that in the control group. Serum levels of HA, PC III, C-IV, LN, TGF beta 1 and TNF-alpha in the treated group obviously reduced after treatment, and the liver function got better with significant difference as compared with those in the control group (P < 0.05 or P < 0.01). Pathological examination of liver biopsy showed that the fibrous tissue in the liver reduced.


CONCLUSIONS
KXBGD has a definite effect of anti-liver fibrosis.
Liang
Tie-jun
TJ
Shandong Provincial Hospital, Jinan 250021.
Zhang
Wei
W
Zhang
Cai-qing
CQ
D000328:Adult; D000368:Aged; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D024061:Collagen Type III; D024141:Collagen Type IV; D004365:Drugs, Chinese Herbal; D006820:Hyaluronic Acid