[Study on hepatic-protective effect of "yinzhihuang" granula].
OBJECTIVE
To study hepatic-protective effect of "Yinzhihuang" granula.


METHODS
By D-GalN, CCl4 induced acute hepatic damage model, ALT and AST in serum, pathological degree of hepar adopted as indexes, the potency of "Yinzhihuang" granula was observed and compared with "Yinzhihuang" oral solutions. Mice administrated ig 1-naphthyl-isothiocyanate, with bilirubin in serum used as index, the effect of "Yinzhihuang" granula was observed.


RESULTS
1.8 g/kg, 3.6 g/kg "Yinzhihuang" granula groups could decrease the rising of ALT, AST in mice serum induced by D-GalN.3.6 g/kg "Yinzhihuang" granula group could also improve pathological degree of hepar.1.0 g/kg, 2.0 g/kg "Yinzhihuang" granula groups could decrease the rising of ALT, AST in rats serum induced by CCl(4).2.0 g/kg "Yinzhihuang" granula group could also improve pathological degree of hepar.1.8 g/kg, 3.6 g/kg "Yinzhihuang" granula groups could decrease the rising of bilirubin in mice serum induced by 1-naphthyl-isothiocyanate.


CONCLUSIONS
"Yinzhihuang" granula had an evident hepatic-protective effect on acute hepatic damage induced by D-GalN or CCl4, and could decrease the rising of bilirubin in mice serum induced by 1-naphthyl-isothiocyanate.
Li
G
G
Shangdong Institute, TCM, Jinan 250014.
Zhu
J
J
Wu
L
L
D015058:1-Naphthylisothiocyanate / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005688:Galactosamine / Q000633:toxicity; D008099:Liver / Q000187:drug effects*; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C070600:yin zhi huang; D015058:1-Naphthylisothiocyanate; D005688:Galactosamine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin