title: [Blood lipids, oxidative resistance of low density lipoproteins, concentration of fat-soluble antioxidants in older people and longevity in Novosibirsk].
abstract: The aim of the study was to evaluate the blood lipid profile, oxidative-antioxidative status of low density lipoproteins (LDL) in old people and long-living people in Novosibirsk. Eighty nine persons from Novosibirsk Veteran House (23 men and 66 women) at the age of 83-105 (average 92.0 +/- 4.0 years old) were included into the study. They were divided into two groups. The group of old people included 12 person at the age of 75-89. The group of long-living people included 77 person at the age of 90-105. The control group consisted of 90 healthy subjects at the age of 36-59. TCH, CH-HDL and TG were measured using biochemical enzyme methods. LDL were isolated from serum by heparin-precipitation method. The initial level of peroxidation lipid (POL) products in LDL and oxidative resistance of precipitated LDL in vitro were evaluated. Concentrations of liposoluble antioxidants (a-tocopherol and retinol) in precipitated LDL were measured by spectro-fluorimetrical methods. The level of CH-HDL was low (< 40 mg/dl) in old and long-living people. In old people the initial level of POL products in LDL was higher in comparison with healthy subjects of control group (p < 0.0001) and long-living people (p < 0.01). In old people and long-living people the oxidative resistance of LDL in vitro was lower (p < 0.0001) in comparison with control group. Moreover, in long-living people the oxidative resistance of LDL in vitro was also lower (p < 0.01) in comparison with old people. The concentration of retinol in LDL was higher only in long-living people compared to the subjects of control group. The concentration of a-tocopherol in LDL was lower in old people and in long-living people (p < 0.05) in comparison with the subjects of control group.
authors.affiliation: Scientific-Research Institute of SO RAMN, Novosibirsk, 630003, Vladimirovski spusk.
authors.forename: A V
authors.initials: AV
authors.lastname: Shabalin
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Nikitin
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Ragino
authors.forename: E V
authors.initials: EV
authors.lastname: Kashtanova
authors.forename: V A
authors.initials: VA
authors.lastname: Pentegova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D012800:Siberia
chemical_list: D000975:Antioxidants; D008055:Lipids; D008077:Lipoproteins, LDL