A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population.
Previous studies have reported genetic linkage evidence for a candidate gene of schizophrenia on chromosome 22q11 but no genes in this region have been really confirmed to be involved in the etiology of schizophrenia so far. Very recently, the proline dehydrogenase gene (PRODH), located in the most centromeric part of the 22q11 microdeletion region, has been reported to be strongly associated with schizophrenia from three sets of independent samples and the most significant evidence for association was derived from a single nucleotide polymorphism-PRODH*1945(T/C). We genotyped this polymorphism in 166 Chinese family trios with schizophrenia from East China. No evidence for preferential transmission of the PRODH*1945 alleles from parents to affected offsprings was found using either Transmission Disequilibrium Test (P=0.4) or Haplotype-based Haplotype Relative Risk analysis (P=0.35). Our results suggest that the 1945(T/C) polymorphism of the proline dehydrogenase gene is unlikely to play a major role in the susceptibility to schizophrenia in the Chinese population.
Fan
Jin-Bo
JB
Bio-X Life Science Research Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, Shanghai 200030, China.
Ma
Jie
J
Zhang
Chang-Shun
CS
Tang
Jun-Xia
JX
Gu
Niu-Fan
NF
Feng
Guo-Ying
GY
St  Clair
David
D
He
Lin
L
D002681:China; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011394:Proline Oxidase / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D011394:Proline Oxidase