Purification strategies for combinatorial and parallel chemistry.
This review surveys the methods developed for the purification of intermediates and final compounds originating from parallel and combinatorial chemistry. Included will be reviews of polymer-assisted purification, liquid-phase combinatorial chemistry, fluorous synthesis, liquid-liquid and solid-phase extraction, reverse-phase HPLC and supercritical fluid chromatography. A critique of each method is given, highlighting the methodologies strengths and weaknesses.
Edwards
Paul J
PJ
Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK. paul_edwards@sandwich.pfizer.com
D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods; D002627:Chemistry, Physical / Q000295:instrumentation / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012680:Sensitivity and Specificity; D012997:Solvents; D013237:Stereoisomerism
D006845:Hydrocarbons, Fluorinated; D011108:Polymers; D012997:Solvents