[Expression of MMP1 and TIMP1 proteins in lung cancer and its biological significance].
OBJECTIVE
To investigate the expression of MMP1 and TIMP1 proteins in lung cancer tissues and its biological significance.


METHODS
MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin-biotin complex in formalin-fixed and routinely paraffin-embeded specimens of 46 patients.


RESULTS
There was no correlation in MMP1 protein expression between normal lung tissues (20%) and lung cancer (52.2%); The positive rate of TIMP1 protein expression was significantly lower in lung cancer (41.3%) than that in normal lung tissues (80%); There was a significant correlation among MMP1 and TIMP1 protein expression and differentiation, TNM stages, and lymph node metastases of lung cancer. There was a significant negative correlation between MMP1 and TIMP1 protein expressions in lung cancer.


CONCLUSIONS
There is a correlation between MMP1 and TIMP1 protein expressions in lung cancer and the invasion and metastasis of lung cancer. The factors may be used as important biological markers in lung cancer.
Peng
Zai-mei
ZM
Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, China.
Yang
Zhu-lin
ZL
Liu
You-wen
YW
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry*; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000032:analysis*; D008875:Middle Aged; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000032:analysis*
D014408:Biomarkers, Tumor; D019715:Tissue Inhibitor of Metalloproteinase-1; D020781:Matrix Metalloproteinase 1