Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
Soderling
Scott H
SH
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA. scott@ohsu.edu
Langeberg
Lorene K
LK
Soderling
Jacquelyn A
JA
Davee
Stephen M
SM
Simerly
Richard
R
Raber
Jacob
J
Scott
John D
JD
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D022202:Chromosomes, Artificial, Bacterial; D003001:Cloning, Molecular; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007858:Learning; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008840:Microfilament Proteins / Q000235:genetics / Q000502:physiology*; D009043:Motor Activity / Q000235:genetics*; D016133:Polymerase Chain Reaction; D051300:Wiskott-Aldrich Syndrome Protein Family
D008840:Microfilament Proteins; C495774:Wasf1 protein, mouse; D051300:Wiskott-Aldrich Syndrome Protein Family