Relapsing cutaneous alternariosis in a kidney transplant recipient cured with liposomal amphotericin B.
An immunosuppressed patient who presented with unusual clinical signs of cutaneous alternariosis, including papular, nodular and verrucous lesions of the forearms, is reported. In spite of continuous treatment with oral itraconazole for 6 months, a large, progressive, necrotic ulcer appeared on the patient's left leg. Liposomal amphotericin B was then administered (total dose, 750 mg) with excellent clinical results.
Merino
E
E
Unit of Infectious Diseases, Hospital General Universitario de Alicante, Pintor Baeza s/n, 03012 Alicante, Spain. merino_luc@gva.es
Bañuls
J
J
Boix
V
V
Franco
A
A
Guijarro
J
J
Portilla
J
J
Betlloch
I
I
D000528:Alternaria / Q000187:drug effects* / Q000302:isolation & purification*; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001707:Biopsy, Needle; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D016030:Kidney Transplantation / Q000276:immunology*; D007871:Leg Ulcer / Q000188:drug therapy* / Q000382:microbiology; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B