title: Organogenesis: making pancreas from liver.
abstract: Making endocrine pancreas cells at will is one of the major goals of cellular based therapies for diabetes. The experimentally induced conversion of hepatocytes into pancreatic cells, using a modified version of the transcription factor Pdx-1, may provide an alternative to stem cell approaches.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition,Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
authors.forename: Valerie A
authors.initials: VA
authors.lastname: McLin
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Zorn
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D018398:Homeodomain Proteins; D008099:Liver / Q000254:growth & development*; D009024:Morphogenesis; D010179:Pancreas / Q000254:growth & development*; D015534:Trans-Activators / Q000378:metabolism*; D019076:Transgenes; D014982:Xenopus laevis / Q000502:physiology
chemical_list: D018398:Homeodomain Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein