[Investigation of the bioadhesion of carbopol and hydroxypropyl methylcellulose to rat gastrointestinal mucosa in vivo and in vitro].
OBJECTIVE
To investigate bioadhesion of carbopol and hydroxypropyl methylcellulose of different viscosity grade to rat gastrointestinal mucosa.


METHODS
The maximum adhesion force has been adopted as an index of adhesive evaluation in vitro, gastro-emptying rate and migrating length in intestine have been adopted as an index of adhesive evaluation in vivo.


RESULTS
In vitro adhesion studies indicated that the adhesive force of low-vicosity materials was stronger than that of high-vicosity materials, while the transferation rate of high-vicosity materials is significantly higher compared to that of low-vicosity materials in vivo.


CONCLUSIONS
Adhesive force of materials gives no correlation with rate of the materials in rat; Cb934 have the optium bioadhesion among the studied materials and can be used as the preferred adjuvant in oral bioadhesion preparation.
Zhang
Z R
ZR
School of Pharmacy, Sichuan University, Chengdu 610041, China. zrzzl@mail.sc.cninfo.net
Fu
J
J
Huang
Y
Y
Duan
Y S
YS
D000180:Acrylic Resins; D000268:Adhesiveness; D000818:Animals; D004337:Drug Carriers; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000378:metabolism*; D005772:Gastrointestinal Transit / Q000502:physiology; D065347:Hypromellose Derivatives; D007413:Intestinal Mucosa / Q000378:metabolism*; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D011145:Polyvinyls / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014783:Viscosity
D000180:Acrylic Resins; D004337:Drug Carriers; D011145:Polyvinyls; C006912:carboxypolymethylene; D065347:Hypromellose Derivatives; D008747:Methylcellulose