Chromosome analysis in 31 cases of benign and malignant breast tumors: a study in Brazil.
Cultures of 31 breast tumors, being 20 carcinomas and 11 benign lesions, were cytogenetically analysed. Clonal chromosome aberrations were detected in 16 carcinomas and in 4 benign lesions. Nine carcinomas and 2 benign lesions had multiple cytogenetically unrelated and related clones, whereas a single abnormal clone was observed in 7 carcinomas and in 2 benign lesions. Polyploid clones were found in 7 carcinomas and in 2 benign lesions. The presence of clonal chromosome aberrations and polyploid cells was not associated with the clinicopathologic parameters tested. Carcinomas had more clonal changes than benign lesions (p = 0.031), showing that cytogenetic features are of diagnostic value and that different chromosome anomalies might have different pathogenetic and prognostic significance.
Benetti
Mara Regina Netto
MR
Department of Genetics, Federal University of Rio Grande do Sul, Brazil. marare@catolico.com.br
Kessler
Rejane Gus
RG
Bittelbrunn
Ana Cristina
AC
Frantz
Bárbara
B
Biazus
Jorge Villanova
JV
Giugliani
Roberto
R
D000328:Adult; D001938:Brazil; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011003:Ploidies