title: [Hypocholesterolemic effect of total isoflavones from Pueraria lobata in ovariectomized rats].
abstract: OBJECTIVE
  To observe the effects of total isoflavones from Pueraria lobata (TIP) on lipid metabolism in estrogen deficient rat.
  
  
  METHODS
  Female SD rats were bilaterally ovariectomized under anesthesia. TIP was administrated orally for 7 months. Serum lipids were determined at 1.5, 4.0 and 7.0 months, and liver lipids were detected at 7 months.
  
  
  RESULTS
  Compared with non-ovariectomized rats, serum TC level and the ration of TC/HDL-C in ovariectomized rats were obviously increased while HLD-C was slightly induced and TG level were changeless. In TIP-treated groups, serum TC level and the ratios of TC/HDL-C were markedly lowered than those in OVX group, while HDL-C slightly increased. TG level were much reduced in 1.5 month and changeless in 4.0 and 7.0 month. Slightly increase of cholesterol and markedly induction of triglyceride tissue were observed in liver.
  
  
  CONCLUSIONS
  TIP significantly decreased concentrations of serum TC and liver TG in OVX rats.
authors.affiliation: Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
authors.forename: Gaoli
authors.initials: G
authors.lastname: Zheng
authors.forename: Xinyue
authors.initials: X
authors.lastname: Zhang
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zheng
authors.forename: Weigui
authors.initials: W
authors.lastname: Gong
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zheng
authors.forename: Anli
authors.initials: A
authors.lastname: Chen
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D004964:Estriol / Q000494:pharmacology; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D007529:Isoflavones; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D004964:Estriol