title: Synthesis of granulatimide positional analogues.
abstract: The Stille coupling reaction of the stannylindole 13 with the 5-iodoimidazole derivative 14 (or 27) in the presence of PdCl(2)(PPh(3))(2) gave the corresponding indole-imidazole coupling product 15 (or 28), thereby affording a synthetic approach to 10-methylgranulatimide (7), 15-methylgranulatimide (11), and 10, 15-dimethylgranulatimide (12), as well as 10-methylisogranulatimide B (5).
authors.affiliation: Showa Pharmaceutical University, Tokyo, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nishiyachi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nakashima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Murase
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kotani
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; C433587:granulatimide