[Evaluation of the risk of vertebral fracture predictable with quantitative tibial ultrasound velocity test in postmenopausal women].
OBJECTIVE
To investigate predicting value of increased risk of vertebral fracture associated with reduction of tibial ultrasound velocity (SOS) test in postmenopausal women.


METHODS
193 menopausal women aged(54.4 +/- 7.3) years were included in our study. Post menopausal period of these subjects were (16.0 +/- 7.8) years. These participants received tibial ultrasound speed (SOS) test, DEXA for lumbar 2-4, femoral neck wards triangle and trochant, as well as SPA for 1/3 and 1/10 of distal forearm. Vertebral fracture was determined by radiograph of lateral lumbar and thoracic spine.


RESULTS
54 subjects were found at least one vertebral deformation, and no vertebral deformation was found in other 139 subjects. Tibial SOS was significantly lower in subjects with than without vertebral fracture [(3,651.9 +/- 188.3) vs (3,731.3 +/- 140.8), P < 0.01], The similar results were also found in BMD. The analysis of logistic regression showed: odds ratio (OR) of SOS to vertebral fracture was 1.86(P < 0.01) when 1 standard deviation of SOS changed. It was lower than OR of BMD by DEXA(2.25-3.28, all P < 0.001), and similar with OR of BMD by SPA (1.50-1.96).


CONCLUSIONS
Low SOS was associated with presence of vertebral fracture in postmenopausal women. SOS could predict the risk of vertebral fracture, 86% of the risk of vertebral fracture increased when 1 standard deviation of SOS reduced.
Xia
W
W
Department of Endocrindogy, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xing
X
X
Liu
H
H
Hu
Y
Y
Zhou
X
X
D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications*; D012307:Risk Factors; D016103:Spinal Fractures / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D013977:Tibia / Q000000981:diagnostic imaging*; D014463:Ultrasonography