title: Sinusitis update.
abstract: OBJECTIVE
  Rhinosinusitis affects more than 10% of the US population. It results in high health care expenditure as well as decreased productivity through lost days of school or work. This review includes recent findings in diagnostics and pathophysiology, as well as recent advances in treatment.
  
  
  RESULTS
  Parameters used in the diagnosis of rhinosinusitis include patient symptomatology, physical and endoscopic findings, computed tomography scan scores, and culture results. There has been poor correlation between patient symptoms and computed tomography scan scores, but middle meatal cultures have been shown to correlate well with ethmoid sinus cultures obtained from chronic rhinosinusitis patients. Chronic inflammation with a predominance of eosinophils and T lymphocytes in the tissues is being recognized as a hallmark of chronic rhinosinusitis, especially in patients with asthma or allergic rhinitis. Th2 cytokines are prominent in sinus tissues of patients with chronic rhinosinusitis and allergic rhinitis. While antibiotics are used with greater frequency in the treatment of acute and chronic rhinosinusitis, adjuvant therapies, such as intranasal steroids, might affect patient symptoms and curb disease recurrence.
  
  
  CONCLUSIONS
  Clinical symptoms are important in making the diagnosis of rhinosinusitis and should be supported by objective findings on nasal endoscopy and, if necessary, computed tomography scans. The mainstay of treatment remains antibiotics, with a potential role for decongestants and intranasal steroids. The presence of chronic inflammation with a Th2 cytokine predominance in sinus tissues should be kept in mind, especially in patients with coexistent morbidities such as allergic rhinitis and asthma.
authors.affiliation: Section of Otolaryngology--Head and Neck Surgery, The Pritzker School of Medicine, University of Chicago, Illinois 60637, USA.
authors.forename: Samantha M
authors.initials: SM
authors.lastname: Mucha
authors.forename: Fuad M
authors.initials: FM
authors.lastname: Baroody
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004724:Endoscopy; D006801:Humans; D014663:Nasal Decongestants / Q000627:therapeutic use; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D013256:Steroids; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014663:Nasal Decongestants; D013256:Steroids