title: Bone augmentation by means of a stiff occlusive titanium barrier.
abstract: It has already been shown that occlusive titanium barriers have osteoconductive properties. These barriers, however, cover only a limited surface area and have only been used in animal experiments. The aim of this study was to evaluate bone neogenesis under a pre-shaped titanium barrier placed over the top of the rabbit skull and the top of highly resorbed edentulous upper-jaw bone in patients. Computed tomography (CT) scans made it possible to pre-shape the titanium barrier according to individual bone shape in human experiments. On the rabbit skull, tissue augmentation of up to 6 mm 1 year after barrier placement was observed, while the original thickness of skull bone was on average between 1.5 and 2.5 mm. The bone, which remained histologically immature for 1 year, grew systematically along the titanium surface, illustrating its osteoconductivity. Even after removal of the barrier, on average, 75.3 and 59.4% of the newly created tissue volume was maintained after 3 and 9 months, respectively. Clinical observations on 10 consecutive patients showed that, in those (5/10) in which the barrier remained unexposed for several months, an increase of the jawbone height and width of up to 16 mm could be observed when the barrier was removed after 12-18 months. As in the rabbits at barrier removal, the bone demonstrated a limited degree of mineralization as ascertained from biopsies. This newly formed osteoid tissue allowed the insertion of 33 screw-shaped titanium implants which in most cases (30/33) successfully osseointegrated to support a fixed prosthesis. The surrounding marginal bone level remained stable even up to 5 years after implant placement. Both animal and clinical data demonstrate that guided bone neogenesis under a subperiosteally placed titanium barrier can reach large volumes.
authors.affiliation: Department of Periodontology, School of Dentistry, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
authors.forename: Daniel
authors.initials: D
authors.lastname: Van Steenberghe
authors.forename: Carina
authors.initials: C
authors.lastname: Johansson
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
authors.forename: Liene
authors.initials: L
authors.lastname: Molly
authors.forename: Tomas
authors.initials: T
authors.lastname: Albrektsson
authors.forename: Ignace
authors.initials: I
authors.lastname: Naert
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000473:pathology; D001862:Bone Resorption / Q000473:pathology / Q000601:surgery; D002113:Calcification, Physiologic / Q000502:physiology; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007575:Jaw, Edentulous / Q000473:pathology / Q000601:surgery; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D023421:Models, Animal; D016348:Osseointegration; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits; D012886:Skull / Q000473:pathology / Q000601:surgery; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D008567:Membranes, Artificial; D014025:Titanium