title: Limited value of routine microbiological diagnostics in patients hospitalized for community-acquired pneumonia.
abstract: Current guidelines recommend microbiological diagnostic procedures as a part of the management of patients hospitalized for community-acquired pneumonia (CAP), but the value of such efforts has been questioned. Patients hospitalized for CAP were studied retrospectively, focusing on the use of aetiological diagnostic methods and their clinical impact. Adult patients, without known human immunodeficiency virus infection, admitted to hospital for CAP during 12 months, were evaluated with regard to the importance of aetiological diagnosis for tailoring antibiotic therapy, antibiotic-associated diarrhoea, Clostridium difficile disease, length of hospital stay and mortality. Of the 605 studied patients, 482 (80%) were subjected to Mycoplasma pneumoniae and/or respiratory virus serology and/or cultures of blood and/or sputum. They had a better prognosis than patients not subjected to microbiological diagnostics (mortality within 3 months was 9% vs 24%, p = 0.001), apparently reflecting differences in general health (e.g. less dementia diagnosis) but not the outcome of diagnostics. A presumptive aetiology was obtained only in 132 of the 482 patients, Streptococcus pneumoniae and M. pneumoniae being the most common agents (in 49 and 36 patients, respectively). Establishing an aetiological diagnosis had no impact on the number of in-hospital changes of therapy, on the proportion of new regimens having a narrower antimicrobial spectrum than the initial one or on the outcome. Therapy was changed to a drug directed specifically against the identified pathogen in only 16 out of these 132 patients and again without any overall improvement in the outcome variables. In a setting with a low frequency of antibiotic-resistant respiratory tract pathogens current routine microbiological diagnostics were found to be of limited value for the clinical management of patients hospitalized for CAP. Improved diagnostics in CAP are urgently needed, as establishing an aetiological diagnosis carries a potential for optimizing the antibiotic therapy.
authors.affiliation: Division of Infectious Diseases, University Hospital Huddinge, Stockholm, Sweden. Christer.Lidman@medhs.ki.se
authors.forename: Christer
authors.initials: C
authors.lastname: Lidman
authors.forename: Lars G
authors.initials: LG
authors.lastname: Burman
authors.forename: Asa
authors.initials: A
authors.lastname: Lagergren
authors.forename: Ake
authors.initials: A
authors.lastname: Ortqvist
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000368:Aged; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D003955:Diagnostic Tests, Routine; D003967:Diarrhea / Q000139:chemically induced; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006760:Hospitalization; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use; D011014:Pneumonia / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D002511:Cephalosporins; D018942:Macrolides; D010406:Penicillins; D004318:Doxycycline