[Application of FAM networks in recommendation of mobile phase for RP-HPLC].
OBJECTIVE
To establish expert system to recommend solvent strength in RP-HPLC by using FAM (fuzzy associate memorizer) networks.


METHODS
Symbolic rules reflecting the quantitative relationship among molecular structure, capacity factors and solvent strength in RP-HPLC were extracted from trained radial basis function networks. Then FAM networks consisting of these rules were built to recommend mobile phase strength for RP-HPLC.


RESULTS
The validation results of the system by monocomponent and mutilcomponent drug samples were satisfied.


CONCLUSIONS
The mobile phase recommendation system for RP-HPLC analysis of drugs showed reliable performance.
Gao
S G
SG
Center for Instrumental Analysis, China Pharmaceutical University, Nanjing 210009, China.
Li
R
R
Xiang
B R
BR
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003907:Dexamethasone / Q000032:analysis; D004338:Drug Combinations; D004656:Enalapril / Q000032:analysis; D005103:Expert Systems; D017143:Fuzzy Logic; D006852:Hydrochlorothiazide / Q000032:analysis; D016571:Neural Networks, Computer
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D004656:Enalapril; D003907:Dexamethasone