Anti-tack action of polyvinylpyrrolidone on hydroxypropylmethylcellulose solution.
The anti-tack action of polyvinylpyrrolidone (PVP) on hydroxypropylmethylcellulose (HPMC) solution was elucidated using a probe test method. The influence of PVP of varying molecular weights at various PVP concentrations and solution temperatures on the tackiness of HPMC solution was studied. The viscosity, surface tension, cloud point and solution spectroscopy of HPMC solutions and glass transition temperature of HPMC films, with and without PVP, were investigated. The tackiness of HPMC solutions in response to the addition of PVP, at different concentrations of HPMC and using HPMC with varying contents of hydroxypropyl/methoxyl substitution, was also evaluated. PVP is a commonly used binder and adhesive. However, it reduced the tack of the HPMC solution when used at low concentrations, without affecting the state of hydration of HPMC. Lower molecular weight PVP was more effective as an anti-tack agent owing to suitable hydrodynamic size to intersperse among the HPMC chains. The degree of reduction in tack values was more pronounced for HPMC that showed a greater extent of interaction between polymer chains such as when high concentration of HPMC or low solution temperature was employed. This indicated that the tack reduction property of PVP relied on its ability to interact with the HPMC chains. The profile of reduction in tack values was affected by the contents of HPMC substitution and was a result of net reduction in the extent of hydrogen bonding between HPMC chains. It was significantly correlated to the changes of viscosity and surface tension of the HPMC solutions but not to the glass transition temperatures of the polymers prepared as solid films. The results suggested that the anti-tack action of PVP was attributed to its ability to interact with HPMC chains in the aqueous medium and consequently to reduce the extent of HPMC-HPMC bonding.
Chan
Lai Wah
LW
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Wong
Tin Wui
TW
Chua
Pih Chng
PC
York
Peter
P
Heng
Paul Wan Sia
PW
D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D019999:Pharmaceutical Solutions / Q000737:chemistry / Q000494:pharmacology; D011205:Povidone / Q000737:chemistry* / Q000494:pharmacology; D013500:Surface Tension / Q000187:drug effects; D014783:Viscosity / Q000187:drug effects
D019999:Pharmaceutical Solutions; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D011205:Povidone