[Immunohistological observation of tonsillae in IgA nephropathy].
OBJECTIVE
To realize the relationship between IgA nephropathy (IgA-N) and immunological abnormality of tonsillae.


METHODS
Thirty-one patients were diagnosed as IgA-N via renal puncture. Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method.


RESULTS
The differences of expression of IgA, IgG in the tonsillae between above two groups were significantly obvious. The number of lymphocytes which can produce IgA increased in IgA-N tonsillae.


CONCLUSIONS
The immune functions are abnormal in IgA-N patients. Tonsillectomy can prevent the antigen invasion, eliminate IgA originated from tonsillae, decrease the IgA immunocomplex in circulation, therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.
Zhou
M
M
Department of Otorhinolaryngology, General Hospital of Nanjing Command, PLA, Nanjing 210002.
Zhou
W G
WG
Yin
H L
HL
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000276:immunology* / Q000473:pathology; D014068:Tonsillectomy
D007070:Immunoglobulin A; D007074:Immunoglobulin G