Effects of Orengedoku-to and Scutellariae radix extract on aqueous flare elevation induced by intravitreal IL-1alpha in pigmented rabbits.
We investigated the effects of Orengedoku-to (huanglian-jie-du-tang in Chinese) and Scutellariae radix extract on experimental aqueous flare elevation in pigmented rabbits. To produce the elevation of aqueous flare in rabbits, interleukin-1 alpha (IL-1alpha) was injected intravitreally. Animals were pretreated with oral administration of 150 g/day of food containing 0.07%, 0.2% or 0.7% (w/w) Orengedoku-to; or 0.02%, 0.07% or 0.2% Scutellariae radix extract for 5 days. The animals were further treated with the same food for 7 days after intravitreal injection of IL-1alpha. Aqueous flare was measured with a laser flare-cell meter. Treatment with 0.2% or 0.7% Orengedoku-to and 0.07% or 0.2% Scutellariae radix extract significantly (p < 0.05) suppressed elevation of aqueous flare induced by IL-1alpha. Thus, orengedoku-to and Scutellariae radix extract have an inhibitory effect on experimental elevation of aqueous flare induced by IL-1alpha in rabbits.
Nakamura
Nobuo
N
Department of Ophthalmology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan.
Nagaki
Yasunori
Y
Hayasaka
Seiji
S
Terasawa
Katsutoshi
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D019540:Area Under Curve; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007267:Injections; D007375:Interleukin-1 / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D010858:Pigmentation / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D031363:Scutellaria / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D010936:Plant Extracts; C061676:oren gedoku to