[Effect of combination of Chinese herbal drugs on clinical bioavailability of ferulic acid in serum].
OBJECTIVE
To observe the effect of combination of Chinese herbal drugs on bioavailability of Ligusticum walichii (LW) derived ferulic acid (FA) in serum.


METHODS
Healthy volunteers were given LW decoction (1 g/kg), LW combined with Paeonia veitchii (PV, 1:1) decoction (2 g/kg) and Coronary Heart No. 2 (CH-II, 3 g/kg, containing LW 0.5 g/kg) once respectively. The serum FA concentration-time (c-t) curve was performed by HPLC using the method established by the authors, and the area under that curve (AUC) was calculated and compared.


RESULTS
The FA c-t curve in the three groups was double peak curve. As compared with the AUC in subjects who were administered LW decoction, the AUC in those taken LW + PV decoction was lower [(15734.88 +/- 7737.97) ng/(min.ml) vs (5717.92 +/- 6124.63) ng/(min.ml)], P < 0.05), while that in those taken CH-II was relatively higher [(8072.00 +/- 4424.31) ng/(min.ml), P > 0.05)].


CONCLUSIONS
Combination of LW and PV could significantly lower the bioavailability of FA, but when LW was added in CH-II, the FA bioavailability was not affected.
Huang
X
X
Department of Clinical Pharmacology of Chinese Drugs, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Ren
P
P
Chen
K J
KJ
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D029596:Paeonia / Q000737:chemistry
D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C004999:ferulic acid