Biological fixation of hydroxyapatite-coated versus grit-blasted titanium hip stems: a canine study.
BACKGROUND
The purpose of the study was to evaluate the influence of a proximal hydroxyapatite (HA) coating in comparison with a grit-blasted titanium surface of an anatomic hip stem in an animal model over a maximum duration of 2 years.


METHODS
Thirty adult dogs underwent implantation of either a proximally HA-coated or a grit-blasted anatomic titanium stem. The animals were clinically evaluated for their walking ability, and serial radiographs were taken. The femora were assessed histomorphologically at set time points from 6 weeks to 2 years postoperatively. Undecalcified thin section specimens through the proximal and distal portion of the coating or grit blasting were prepared. The percentage of implant surface with direct bone contact without connective tissue involvement was determined.


RESULTS
Radiographically, animals with uncoated prostheses showed characteristic signs of loosening more frequently. Histomorphometrically, an average of 65% of the surface of HA-coated implants had bone contact, but only 14.7% of the surface of grit-blasted prostheses ( p=0.0001). There was no relationship between bone contact and the duration of implantation of the prosthesis, either for the coated or for the uncoated prostheses. HA coating enhances osseointegration of an anatomic hip stem.


CONCLUSIONS
Anatomic stems with rounded design require a surface coating or surface structure, since the mere grit-blasting of the titanium surface does not ensure osseointegration in this animal model.
Eckardt
Anke
A
Department of Orthopaedics, University School of Medicine, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany. eckardt@mail.uni-mainz.de
Aberman
Harold M
HM
Cantwell
H Dan
HD
Heine
Jochen
J
D000818:Animals; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology*; D006622:Hip Prosthesis; D020007:Implants, Experimental; D016348:Osseointegration / Q000502:physiology; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012680:Sensitivity and Specificity; D014025:Titanium; D016474:Weight-Bearing
D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium