[Cultivation of fibroblasts derived from urethral scar and the effects of salviae miltiorrhizae and ligustrazine on its growth].
OBJECTIVE
To explore the possible effect and related mechanism of salviae miltiorrhizae (SM) and ligustrazine in the treatment of urethral scar.


METHODS
In vitro cultivation of fibroblasts derived from urethral scar has been developed. The effects of these two medicines on its morphology and proliferation have been detected based on the in vitro culture system.


RESULTS
The spindle cells were found to become elliptical in shape. The two medicines inhibited the proliferation of fibroblasts derived from urethral scar, and this may be resulted from their inhibitive effects on cell division rather than cell necrosis or degradation.


CONCLUSIONS
Salviae multiorrhizae and ligustrazine as effective scar inhibitors may have application prospects in the treatment of urethral stricture.
Huang
Xiang
X
Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Shen
Jihong
J
Li
Hong
H
Wang
Kunjie
K
Wei
Dapeng
D
Yang
Yuru
Y
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002921:Cicatrix / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D008297:Male; D010936:Plant Extracts; D011719:Pyrazines / Q000494:pharmacology*; D027561:Salvia miltiorrhiza; D014525:Urethral Stricture / Q000473:pathology*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011719:Pyrazines; C017953:tetramethylpyrazine