title: A preliminary study of baclofen-induced growth hormone release in generalised social phobia.
abstract: OBJECTIVE
  The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen.
  
  
  METHODS
  Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period.
  
  
  RESULTS
  The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response.
  
  
  CONCLUSIONS
  The results suggest an abnormality of central GABA(B) receptor function in this disorder.
authors.affiliation: Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.
authors.forename: Rita M
authors.initials: RM
authors.lastname: Condren
authors.forename: Jim V
authors.initials: JV
authors.lastname: Lucey
authors.forename: Jogin H
authors.initials: JH
authors.lastname: Thakore
mesh_terms: D000328:Adult; D001418:Baclofen / Q000494:pharmacology*; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D058786:GABA-B Receptor Agonists; D019382:Human Growth Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D018755:GABA Agonists; D058786:GABA-B Receptor Agonists; D019382:Human Growth Hormone; D001418:Baclofen