title: Method for three-dimensional data registration from disparate imaging modalities in the NOGA Myocardial Viability Trial.
abstract: Region-by-region comparison of data concerning left ventricular (LV) status is difficult to perform quantitatively if the data was acquired from disparate imaging modalities. We validated a method for comparing measurements obtained by electromechanical mapping (EMM) catheter with dobutamine stress echocardiography (DSE) via biplane contrast ventriculography, with the assistance of three-dimensional (3-D) echocardiographic data. The ventriculograms were traced and the borders were used to reconstruct the LV in 3-D with the aid of a database of 3-D echocardiographic studies. The 3-D LV was oriented to the EMM data based on the body coordinates and then manually scaled and translated to fit. The EMM data were mapped to the 3-D surface. The 3-D surface was divided into the 16 regions defined for echocardiographic assessment. The mean EMM value for local linear shortening, a parameter of function, was computed in each segment. The EMM and semiquantitative echocardiographic assessments of regional myocardial function were compared by segment, and the volume of the 3-D LV was compared with the volume computed from the ventriculogram. The volume of the 3-D surface correlated closely with that of the ventriculogram (r = 0.97, SEE = 27.4 ml) but with a significant overestimation of 63 +/- 35 ml. There was a highly significant (p < 0.0001) agreement in regional function between EMM and echo. Local linear shortening correlated significantly (p < 0.0001) with echocardiographic severity of wall motion, averaging 9.5 +/- 6.5, 8.1 +/- 5.4, 5.9 +/- 4.8, and 6.2 +/- 3.3 in segments read as normal, hypokinetic, akinetic, and dyskinetic, respectively. The method presented is valid for comparing cardiac parameters derived from disparate image data on a region-by-region basis by employing anatomic landmarks on 3-D reconstructions of the LV endocardial surface.
authors.affiliation: Cardiovascular Research and Training Center, University of Washington, Seattle, WA 98195-9394, USA. sheehan@u.washington.edu
authors.forename: Florence H
authors.initials: FH
authors.lastname: Sheehan
authors.forename: Edward L
authors.initials: EL
authors.lastname: Bolson
authors.forename: John A
authors.initials: JA
authors.lastname: McDonald
authors.forename: Mark
authors.initials: M
authors.lastname: Reisman
authors.forename: Karl-Christian
authors.initials: KC
authors.lastname: Koch
authors.forename: Athena
authors.initials: A
authors.lastname: Poppas
mesh_terms: D018780:Body Surface Potential Mapping / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods; D004452:Echocardiography / Q000379:methods; D015637:Gated Blood-Pool Imaging; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014022:Tissue Survival / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology