Overrepresentation of a gene family encoding extracytoplasmic solute receptors in Bordetella.
A family of genes that are likely to encode extracytoplasmic solute receptors is strongly overrepresented in several beta-proteobacteria, including Bordetella pertussis. This gene family, of which members have been called bug genes, contains some examples that are contained within polycistronic operons coding for tripartite uptake transporters of the TTT family, while the vast majority are "orphan" genes. Proteomic and functional analyses demonstrated that several of these genes are expressed in B. pertussis, and one is involved in citrate uptake. The bug genes probably form an ancient family that has been subjected to a large expansion in a restricted phylogenic group.
Antoine
Rudy
R
INSERM U447. CNRS UMR 8525, Institut de Biologie de Lille, Institut Pasteur de Lille, 59019 Lille Cedex, France.
Jacob-Dubuisson
Françoise
F
Drobecq
Hervé
H
Willery
Eve
E
Lesjean
Sarah
S
Locht
Camille
C
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D001884:Bordetella / Q000235:genetics / Q000378:metabolism*; D019343:Citric Acid / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D009876:Operon; D010802:Phylogeny; D040901:Proteomics; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D011956:Receptors, Cell Surface; D019343:Citric Acid