title: [Clinical immunological study on prevention and treatment of chronic pyelonephritis with yishenkang granule].
abstract: OBJECTIVE
  To investigate the relationship between chronic pyelonephritis (CPN) and immune function, and the therapeutic mechanism of Yishenkang granule (YSKG).
  
  
  METHODS
  One hundred and twenty patients of CPN were divided into 3 groups randomly, the YSKG group (treated with YSKG), the control A group (treated with Sanjin tablet) and the control B group (treated with western medicine). Serum levels of immunoglobulin (Ig), complement 3 (C3), interleukin-2 (IL-2), peripheral T-lymphocyte subsets, and urinary secretory immunoglobulin A (sIgA) were determined before and after treatment with monoclonal antibody assay, agar diffusion method, radioimmunoassay (RIA), and radioimmuno-equilibrium method, and compared with normal control.
  
  
  RESULTS
  There were disorders of T-lymphocyte subsets in CPN, lowering of serum Ig, C3 and urinary sIgA, and increase of blood IL-2 (P < 0.05 or P < 0.01). These abnormalities could be normalized after YSKG treatment.
  
  
  CONCLUSIONS
  Functional disorders of cellular and humoral immunity exist in CPN patients of chronic stage, YSKG could correct the immune functional disorder, control the recurrence of CPN effectively and alleviate the immunopathological damage.
authors.affiliation: Heilong Jiang College of TCM, Harbin 150040.
authors.forename: Jian-shi
authors.initials: JS
authors.lastname: Sun
authors.forename: Yan-qiu
authors.initials: YQ
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Meng
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003176:Complement C3 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
chemical_list: D003176:Complement C3; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D007376:Interleukin-2