title: A structural view of integrin activation and signaling.
abstract: Integrins connect the matrix to the cytoskeleton and propagate structural order between the two systems. A series of elegant structural papers now provides a compelling explanation of how integrins perform this basic function.
authors.affiliation: Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Filippo G
authors.initials: FG
authors.lastname: Giancotti
mesh_terms: D002448:Cell Adhesion; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016023:Integrins