title: [Effect of dibutyl phthalate on demodicidosis].
abstract: OBJECTIVE
  To evaluate the curative effect and safety of dibutyl phthalate on demodicidosis.
  
  
  METHODS
  A single blinded and controlled study of human demodicidosis treated with dibutyl phthalate was conducted. One hundred and forty three patients with demodicidosis, including 81 acne and 62 rosacea, randomly divided into trial and control groups. The trial group was treated with dibutyl phthalate and control group with "new fumanling" cream twice a day in the early morning and evening respectively for six weeks consecutively.
  
  
  RESULTS
  The rates of excellent, good, and fair efficacy and total effective rate in the trial group with acne were 53.7%, 41.5%, 4.9% and 100% respectively, with a significant difference to the control group (P < 0.05). The rates in the trial group with rosacea were 40.6%, 40.6%, 18.8% and 100% respectively, with no statistical difference to the control group (P > 0.05). No complaint of side effects in the trial group was recorded.
  
  
  CONCLUSIONS
  Dibutyl phthalate is highly effective to demodicidosis without prominent adverse reactions.
authors.affiliation: Department of Parasitology, Medical Collage of Shandong University, Jinan 250012.
authors.forename: F S
authors.initials: FS
authors.lastname: Yuan
authors.forename: S L
authors.initials: SL
authors.lastname: Guo
authors.forename: Z X
authors.initials: ZX
authors.lastname: Qiu
authors.forename: S H
authors.initials: SH
authors.lastname: Deng
authors.forename: G H
authors.initials: GH
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D003993:Dibutyl Phthalate / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy*; D012393:Rosacea / Q000188:drug therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D003993:Dibutyl Phthalate