title: Flavonols from Scurrula ferruginea Danser (Loranthaceae).
abstract: Three natural flavonols compounds have been isolated from the ethyl acetate fraction of Scurrula ferruginea Danser (Loranthaceae). Besides quercetin and quercitrin, an unusual flavonol glycoside 4"-O-acetylquercitrin was isolated. Structures were determined using spectroscopic methods including UV, NMR and HRMS-EI. The incidence of 4"-O-acetylquercitrin, not previously reported in the Loranthaceae, is discussed. Cytotoxic evaluation on four human cancer cell lines showed quercetin to be the most active with IC50 of 35 microM on U251 (human glioblastoma cells).
authors.affiliation: Laboratoire de Pharmacognosie et de Mycologie, UPRES 2234, Rennes Cedex. lohezic.francoise@libertysurf.fr
authors.forename: Françoise
authors.initials: F
authors.lastname: Lohézic-Le Dévéhat
authors.forename: Sophie
authors.initials: S
authors.lastname: Tomasi
authors.forename: Didier
authors.initials: D
authors.lastname: Fontanel
authors.forename: Joël
authors.initials: J
authors.lastname: Boustie
mesh_terms: D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D028183:Loranthaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005419:Flavonoids