Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas.
An unusual course was observed in a patient with indolent T-prolymphocytic leukaemia (T-PLL) who subsequently developed mycosis fungoides (Mf), lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL). Polymerase chain reaction analysis demonstrated identical monoclonal T-cell receptor-beta and -gamma gene rearrangements in all the different clinical entities. Furthermore, cytogenetic studies revealed the same aberrant clone with trisomy of chromosome 8 in T-PLL and ALCL cells. This unique observation suggests that in T-PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T-cell lymphoma.
Assaf
Chalid
C
Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany. assaf@zedat.fu-berlin.de
Hummel
Michael
M
Dippel
Edgar
E
Schwartz
Stefan
S
Geilen
Christoph C
CC
Harder
Lana
L
Siebert
Reiner
R
Steinhoff
Matthias
M
Klemke
Claus-Detlev
CD
Thiel
Eckhard
E
Goerdt
Sergij
S
Stein
Harald
H
Orfanos
Constantin E
CE
D000368:Aged; D018450:Disease Progression; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*