[Clinical study on regulatory effect of liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal neoplasm].
OBJECTIVE
To study the regulatory effect of Liandai Capsule on p21ras and mutant p53 protein expression in gastrointestinal (GI) neoplasm.


METHODS
Forty-five patients of GI neoplasm in middle or advanced stage were enrolled and divided randomly into the treated group and the control group to observe the changes of their serum p21ras and mutant p53 protein expression as well as their quality of life (QOL) before and after treatment.


RESULTS
The content of p21ras and mutant p53 protein expression in the treated group decreased significantly and QOL improved after treatment, P < 0.05 or P < 0.01, while these changes in the control group were not shown.


CONCLUSIONS
Liandai Capsule has regulatory effect on p21ras and mutant p53 protein expression in GI neoplasm.
Yang
C B
CB
Piwei-Institute, Guangzhou University of TCM, Guangzhou 510407.
Chen
W W
WW
Wang
J H
JH
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D002214:Capsules; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D008517:Phytotherapy; D016283:Proto-Oncogene Proteins p21(ras) / Q000096:biosynthesis* / Q000235:genetics; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016159:Tumor Suppressor Protein p53; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)