title: Bioavailability of omega-3 essential fatty acids from perilla seed oil.
abstract: Increased dietary intake of fish oil omega-3 fatty acids, eicosapentanoic acid and docosohexanoic acid, and their precursor, alpha-linolenic acid (ALA), is associated with various health benefits. Enteric-coating (Entrox), which improves stability of omega-3 capsules, has been shown to facilitate fish oil absorption after chronic treatment. To assess the effect of Entrox coating on the short-term bioavailability of ALA administered in the form of ALA-rich Perilla seed oil, 12 healthy subjects (6 males and 6 females) received in a random order Entrox-coated and non-coated ALA formulations, each as a single 6g dose separated by a 3-week washout period. Measurements of plasma ALA concentrations from 0 to 24h showed no difference in ALA pharmacokinetics between the two formulations. However, significantly greater increases in plasma ALA levels from baseline to 24h were observed after ingestion of Entrox vs. non-coated product, suggesting a possible benefit of Entrox with long-term treatment.
authors.affiliation: KGK Synergize, Inc., One London Place, 255 Queens Avenue, Suite 1030, London, Ont., Canada N6A 5R8. kurowska@kgksynergize.com
authors.forename: E M
authors.initials: EM
authors.lastname: Kurowska
authors.forename: G K
authors.initials: GK
authors.lastname: Dresser
authors.forename: L
authors.initials: L
authors.lastname: Deutsch
authors.forename: D
authors.initials: D
authors.lastname: Vachon
authors.forename: W
authors.initials: W
authors.lastname: Khalil
mesh_terms: D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D015118:Eicosapentaenoic Acid; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D031343:Perilla; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013608:Tablets, Enteric-Coated; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D013608:Tablets, Enteric-Coated; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; C058216:perilla seed oil; D015118:Eicosapentaenoic Acid