title: P 53 and PCNA in Non Hodgkin's lymphoma--an immunohistochemical evaluation.
abstract: P 53 positivity and PCNA labelling index were studied in 50 cases of node based Non Hodgkin's lymphomas, P 53 positivity was observed in a spectrum of these disorders, suggesting that P 53 mutations play a role in the genesis of these tumours. P 53 positivity incresed from low through intermediate to high grade tumours and thus may be of prognostic value in these lesions. PCNA labelling index (LI) was higher in high grade tumours. P 53 and PCNA immunoreactivity showed a relationship in that PCNA LI was seen to be more than 30% in P 53 positive tumours. P 53 positivity appears to be related to the subtype and proliferation rate of NHL.
authors.affiliation: Department of Pathology, Dr. A.L. Mudaliar, Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600113.
authors.forename: U
authors.initials: U
authors.lastname: Burra
authors.forename: P
authors.initials: P
authors.lastname: Shanthi
authors.forename: K B
authors.initials: KB
authors.lastname: Krishnan
authors.forename: M
authors.initials: M
authors.lastname: Madhavan
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53