title: Chemotherapeutic targeting of etoposide to regions of the brain on the basis of polyamine level.
abstract: The effects of etoposide on body weight, regional weights, and the concentrations of putrescine, spermidine and spermine in the cerebellum, hippocampus, corpus striatum, cortex, the combined regions of the thalamus and hypothalamus and the diencephalon of the brain were examined in rats. Etoposide seems to be a better choice for management of cortical and hippocampal tumors because it reduces polyamines, which are associated with tumor cell growth, but not for the management of tumors of the diencephalon and corpus striatum because it increases polyamines.
authors.affiliation: Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan. sunsw@med.kawasaki-m.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Watanabe
authors.forename: Shoichi
authors.initials: S
authors.lastname: Sato
authors.forename: Sumika
authors.initials: S
authors.lastname: Nagase
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimosato
authors.forename: Seitaro
authors.initials: S
authors.lastname: Ohkuma
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D005047:Etoposide / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011073:Polyamines; D005047:Etoposide