[Effect of folium ginkgo extract on the erythrocyte immunity function and serum lipid peroxide in asphyxia neonate].
OBJECTIVE
To observe the changes of erythrocyte immunity and serum lipid peroxide in asphyxia neonate, and to study the effect of Folium Ginkgo extract (FGE) on them.


METHODS
Thirty asphyxia neonates were randomly divided into 2 groups, the treated group and the control group, 15 in each group. Erythrocyte C3b receptor rosette rate (E-C3bRR), erythrocyte immune complex rosette rate (E-ICR), blood superoxide dismutase (SOD) activity and serum lipid peroxide (LPO) level were determined at 24 hrs after birth. Conventional treatment was given to both groups and FGE (15 mg/kg.d) was given to the treated group additionally for 7-8 days, then the above-mentioned parameters were re-examined and neonatal behavioral neurological assessment (NBNA) was measured as well.


RESULTS
E-C3bRR and SOD lowered, E-ICR and serum LPO increased in the asphyxia neonate significantly (P < 0.05). After treatment, comparison between the two groups showed that E-C3bRR and SOD were higher, E-ICR and serum LPO were lower in the treated group than those in the control group, and NBNA scoring was obviously higher in the former than that in the latter (all P < 0.05).


CONCLUSIONS
Decrease of erythrocyte immunity in asphyxia neonate is related to the declined anti-oxidation ability and lipid peroxidase injury. FGE could suppress the free radical production, scavenge free radicals, antagonize the lipid peroxidation injury of cell membrane and up-regulate erythrocyte immunity. It displays the effects of nerve tissue protection and hypoxia-ischemic brain injury alleviation.
Wang
Ling
L
Department of Pediatrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038.
Wu
Xiao-yu
XY
D001238:Asphyxia Neonatorum / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D017463:Receptors, Complement 3b / Q000097:blood*; D012397:Rosette Formation; D013482:Superoxide Dismutase / Q000097:blood
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D017463:Receptors, Complement 3b; D013482:Superoxide Dismutase