Catheter-related sepsis due to Rhodotorula glutinis.
We describe a central venous catheter-related (Port-A-Cath; Smiths Industries Medical Systems [SIMS] Deltec, Inc., St. Paul, Minn.) infection caused by Rhodotorula glutinis in a 51-year-old man with nasopharyngeal carcinoma. He was treated with fluconazole for 8 weeks and had the catheter removed. Two isolates of R. glutinis recovered from blood specimens (one obtained via peripheral veins and one via the catheter) before administration of fluconazole and one recovered from the removed catheter 17 days after initiation of fluconazole therapy exhibited high-level resistance to fluconazole (MICs, >256 microg/ml). These three isolates were found to belong to a single clone on the basis of identical antibiotypes determined by the E test (PDM Epsilometer; AB Biodisk, Solna, Sweden) and biotypes determined by API ID32 C (bioMerieux, Marcy I'Etoile, France) and their identical random amplified polymorphic DNA patterns.
Hsueh
Po-Ren
PR
Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. hsporen@ha.mc.ntu.edu.tw
Teng
Lee-Jene
LJ
Ho
Shen-Wu
SW
Luh
Kwen-Tay
KT
D000935:Antifungal Agents / Q000627:therapeutic use; D002404:Catheterization / Q000009:adverse effects; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D012248:Rhodotorula / Q000187:drug effects / Q000302:isolation & purification*; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology*
D000935:Antifungal Agents; D015725:Fluconazole