Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats.
The study was to investigate the protective effect of antioxidants against methimazole (MMI) induced hypothyroidism in rats. Male Wistar rats were fed MMI, MMI plus vitamin C, MMI plus vitamin E and MMI plus turmeric extract (TE) supplemented diet. At the end of the experiments, thyroid weights, thyroxine (T4), triiodothyronine (T3) and cholesterol levels were determined. It was observed that MMI treated rats showed increase in thyroid weights, very low levels of circulating T4, T3 and increased levels of total cholesterol as compared to controls (P< 0.001). However, rats which received Vit. C, Vit. E or TE along with MMI showed reduced weights (38-55% less) in thyroid glands (P < 0.01), less suppressed T4 and T3 levels (2-6% and 7-35% respectively) and less increase in total cholesterol levels (19-52%) which are statistically significant. The data suggest the positive effect of antioxidants on thyroid gland which could be due to direct involvement of antioxidants on thyroid gland.
Deshpande
Usha R
UR
Radiation Medicine Centre (BARC), C/o Tata Memorial Centre Annexe, Parel, Mumbai 400 012, India.
Joseph
Lebana J
LJ
Patwardhan
Uma N
UN
Samuel
Aban M
AM
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D013956:Antithyroid Agents / Q000009:adverse effects*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003212:Condiments; D030024:Curcuma; D019587:Dietary Supplements; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008713:Methimazole / Q000009:adverse effects*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D013956:Antithyroid Agents; D010936:Plant Extracts; D014284:Triiodothyronine; D014810:Vitamin E; D008713:Methimazole; C012596:turmeric extract; D002784:Cholesterol; D001205:Ascorbic Acid; D013974:Thyroxine