title: Lingual squamous cell carcinoma in a California sea lion (Zalophus californianus).
abstract: A 28-yr-old female California sea lion (Zalophus californianus) in a commercial aquarium developed an ulcerated lingual tumor and died. Necropsy revealed a moderately differentiated squamous cell carcinoma. Immunohistochemical staining and electron microscopic studies revealed that the tumor cells were strongly positive with anti-keratin-cytokeratin antibody and had abundant tonofibrils and desmosomes. The neoplasm had metastasized to a mandibular lymph node.
authors.affiliation: Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sato
authors.forename: Tomomi
authors.initials: T
authors.lastname: Higuchi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Shigeo
authors.initials: S
authors.lastname: Ohba
authors.forename: Sadao
authors.initials: S
authors.lastname: Nogami
authors.forename: Wataru
authors.initials: W
authors.lastname: Shirai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Honda
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008207:Lymphatic Metastasis; D046070:Sea Lions; D014062:Tongue Neoplasms / Q000473:pathology / Q000662:veterinary*