[Apoptotic morphological changes and TUNEL of human gastric cancer cell SGC-7901 induced by aining].
OBJECTIVE
To investigate the inducing apoptosis effect of Aining on the human gastric cancer cell SGC-7901.


METHODS
In vitro cell culture was adopted to explore the inducing apoptosis effect of Aining and cisplation (DDP) through the morphological method and the molecular method.


RESULTS
Apoptotic morphological changes were seen after the cells cultured with Aining or DDP; apoptosis rate of 1 g/L Aining group was 46.36%, which had no significant differences with the apoptosis rate 49.12% of the 25 mg/L DDP group; both of the Aining and the DDP groups were significantly different from that of the blank group(P < 0.01).


CONCLUSIONS
Both DDP and Aining could induce the apoptosis of human gastric cancer cell and the traditional medicine compound prescription Aining is likely to become a new agent which is used to induce apoptosis of cancer cells.
Su
Miancheng
M
National Engineering Research Center for Mordernization of TCM, Zhuhai 519020.
Dai
Mei
M
Lü
Xiaoying
X
Liu
Jilin
J
Li
Hongkun
H
D017209:Apoptosis / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D020287:In Situ Nick-End Labeling; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal; D002945:Cisplatin