[Study on induction of ginsenosides on HL-60 cell apoptosis].
OBJECTIVE
To observe whether the Ginsenosides (GS) could induce HL-60 cell line apoptosis from promyelocytic leukemia.


METHODS
HL-60 cells were treated with GS of various concentration to observe the effect of GS on cell morphological change, the DNA content change by flow cytometry, DNA ladder by electrophoresis, and apoptosis rate by Annexin V-FITC test of the cells.


RESULTS
GS could inhibit the growth of HL-60 cells and induce cell apoptosis in a certain scope of dose and reacting time.


CONCLUSIONS
GS could specifically induce apoptosis in HL-60 cells, which provides an experimental basis for treatment of leukemia with GS as an supplemntary agent of chemotherapy.
Niu
Yang-ping
YP
Institute of Hematopathy, Zhejiang Provincial TCM Hospital, Hangzhou 310006.
Gao
Ruilan
R
Helen
Tao
T
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000032:analysis; D036145:Ginsenosides / Q000494:pharmacology*; D018922:HL-60 Cells / Q000473:pathology; D006801:Humans
D004273:DNA, Neoplasm; D036145:Ginsenosides