[Experimental pharmacodynamic study on the anti-convulsion effect of shenpu decoction].
OBJECTIVE
To observe the anti-convulsion effect of Shenpu Decoction (SPD).


METHODS
Experiments were conducted in three acute convulsion models (cardiazol seizure, strychnine convulsion and maximal electrical shock). Models were divided into the control group (A, treated by normal saline), the high, middle and low dose SPD groups (B, C and D, treated with SPD 9 g/kg, 6 g/kg and 4 g/kg respectively), and the nitrazepam treated group (E). The anti-convulsion effect of SPD was evaluated by 50% convulsion dose (CD50) detected in each group.


RESULTS
In cardiazol convulsion model, the CD50 detected in group A-E were 63.3 +/- 3.4 mg/kg, 116.2 +/- 3.4 mg/kg, 105.6 +/- 3.7 mg/kg, 74.0 +/- 3.7 mg/kg and 197.2 +/- 3.3 mg/kg respectively, while they were 0.71 +/- 0.04 mg/kg, 1.21 +/- 0.04 mg/kg, 1.19 +/- 0.04 mg/kg, 0.94 +/- 0.04 mg/kg and 1.16 +/- 0.04 mg/kg respectively in the strychnine convulsion model, and 67.1 +/- 2.6 V, > 140 V, 109.4 +/- 3.5 V, 84.4 +/- 3.1 V and 128.4 +/- 3.9 V in the maximal electrical shock model respectively.


CONCLUSIONS
SPD has a good anticonvulsion effect.
Wang
L F
LF
General Hospital of PLA, Beijing 100853.
Zhao
M L
ML
Liu
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004558:Electric Stimulation; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D011897:Random Allocation; D013331:Strychnine
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D013331:Strychnine; D010433:Pentylenetetrazole