title: Non-functioning adrenal cortical carcinoma presenting with metastasis to the tongue.
abstract: We report a case of non-functioning adrenal cortical carcinoma (ACC) presenting with metastatic disease to the tongue, which is an extremely uncommon onset for this neoplasm. Histologically, the lesion had the appearance of an anaplastic neoplasm, and a panel of immunohistochemical markers including vimentin, MART-1, S100 protein, HMB-45, smooth muscle actin, common muscle actin, desmin, CD31, CD34, CD68, EMA and cytokeratins, was helpful in excluding melanoma, as well as other mesenchymal and epithelial neoplasms.
authors.affiliation: Department of Urology, University of Florence Medical School, Florence, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Dominici
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Rizzo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Travaglini
authors.forename: Gabriella
authors.initials: G
authors.lastname: Nesi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Franchi
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma / Q000473:pathology / Q000556:secondary*; D000708:Anaplasia; D000951:Antigens, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D058965:MART-1 Antigen; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology / Q000556:secondary*; D014746:Vimentin / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009363:Neoplasm Proteins; D014746:Vimentin