[Longevity of Drosophila after exposure to low doses of radiation and etoposide].
The review of perennial researches of the authors on a problem of radiation-induced aging is presented. From the point of view of radiogenetics it is represented perspective to investigate influence of an exogenous irradiating in small doses on fruit fly with defined mutation by phenotypes, that allows to repute a role of separate genes and mechanisms, controlled by them, in a determination of lifetime. At lines described by differences in pattern of mobile genetical elements, the different reaction to an irradiating explained from the point of view of features of the given mobile elements is found. The processing etoposide in concentration 5 microM on preimaginal stages of line with defects of a reparation (mei-41D5) and hypersensibility to an induction apoptosis (wg1-7, wg7L74, th1 [symbol: see text] th4) results in down-stroke of lifetime. The dominant effect of a gene mei-41D5 in a regulation of etoposide-induced change of lifetime is found. Is exhibited, that at lines with defects proapoptosis of genes reaper and Dcp1, the lifetime after influence, both ionizing irradiating, and inducer apoptosis etoposide is enlarged in comparison with the control.
Moskalev
A A
AA
Institute of Biology, Komi Centre of Science, Ural Division of RAS, State University, Syktyvkar, Russia.
Zaĭnullin
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VG
D000818:Animals; D017209:Apoptosis; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D005047:Etoposide / Q000494:pharmacology*; D008136:Longevity; D011839:Radiation, Ionizing
D005047:Etoposide