Absence of urinary tract infection in dogs with experimentally induced hyperadrenocorticism.
Objectives of this study were to determine occurrence of urinary tract infection and describe results of urine analysis and urine culture in dogs with experimentally induced hyperadrenocorticism. Dogs were randomly assigned to receive either hydrocortisone (nine dogs) or placebo (eight dogs) for 49 consecutive days. Before and on day 49 of treatment, evaluation of dogs included physical examination, abdominal ultrasound, urine culture, urinalysis, adrenal function testing, and measurement of urine protein and creatinine and activity of serum alkaline phosphatase. All dogs in the experimental group had clinical and laboratory findings of hyperadrenocorticism. Urine specific gravity was significantly decreased and urine protein-to-creatinine ratio was significantly increased in dogs with hyperadrenocorticism. Urinary tract infection did not occur in any dogs. We conclude that administration of hydrocortisone created a model of hyperadrenocorticism; however, urinary tract infection did not occur. Additional evaluation is needed to determine association between urinary tract infection and hyperadrenocorticism.
Forrester
S D
SD
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA. sdru@vt.edu
Martínez
N I
NI
Panciera
D L
DL
Moon
M L
ML
Pickett
C R
CR
Ward
D L
DL
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D006929:Hyperaldosteronism / Q000139:chemically induced / Q000150:complications* / Q000662:veterinary*; D008297:Male; D014552:Urinary Tract Infections / Q000150:complications* / Q000662:veterinary*
D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone