[Genotypes of merozoite surface protein 2 of Plasmodium falciparum in different malaria endemic areas].
OBJECTIVE
To determine the genotypes and distribution of MSP2 of Plasmodium falciparum isolates in Yunnan and Hainan provinces, China.


METHODS
The central polymorphic region of MSP2 allele was amplified by the nested PCR for genotyping of P. falciparum.


RESULTS
The higher degree of polymorphism of MSP2 of P. falciparum was observed in Yunnan and Hainan. Distribution and allele frequencies differed in both provinces, indicating considerable geographical heterogeneity of parasite populations. The mixed infection of different allele-type and multiplicity of infection was more frequent in Hainan than in Yunnan.


CONCLUSIONS
There were obvious differences in the distribution and frequencies of MSP2 alleles between Yunnan and Hainan endemic areas. MSP2 is suitable to be used as a marker gene for the genotyping of P. falciparum infection.
Zhu
X P
XP
Department of Parasitology, Capital University of Medical Sciences, Beijing 100054.
Zhou
L
L
Zhang
X M
XM
Yang
J
J
Yang
Y P
YP
D000483:Alleles; D000818:Animals; D002681:China / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic