[Preliminary screen of anti-endotoxin activity of Chinese materia medica].
OBJECTIVE
To screen Chinese materia medica against E. coli. O111B4 endotoxin.


METHODS
70% alcohol extracts from 134 kinds of heat-clearing Chinese materia medica were demonstrated by using limulus test in vitro. The extracts which had anti-endotoxin effects were diluted to demonstrate their minimal anti-endotoxin concertnations.


RESULTS
75 kinds of Chinese materia medica possessed anti-endotoxin activity in various degrees in vitro.


CONCLUSIONS
Most of heat-clearing Chinese materia medica possess anti-endotoxin effects in vitro.
Liu
Y
Y
Tongjji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Wang
Y
Y
Han
H
H
Huang
M
M
D000371:Agglutination / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D004926:Escherichia coli; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D004731:Endotoxins