title: Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.
abstract: After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.
authors.affiliation: Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
authors.forename: Rodrig
authors.initials: R
authors.lastname: Marculescu
authors.forename: Katrina
authors.initials: K
authors.lastname: Vanura
authors.forename: Trang
authors.initials: T
authors.lastname: Le
authors.forename: Paul
authors.initials: P
authors.lastname: Simon
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jäger
authors.forename: Bertrand
authors.initials: B
authors.lastname: Nadel
mesh_terms: D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D019457:Chromosome Breakage; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C086540:TAL2 protein, human