title: Essential role for Vav1 in activation, but not development, of gammadelta T cells.
abstract: Vav1 is a guanine nucleotide exchange factor essential in the development and function of alphabeta lineage T cells. Here we report that in contrast to profound effects on pre-TCR- or alphabeta TCR-dependent events in thymocyte development, Vav1 deficiency has no detectable effect on the development of gammadelta T cells. Strikingly, however, these gammadelta T cells are markedly deficient in signaling through the gammadelta TCR, as evidenced by a lack of proliferation and cytokine production in response to stimulation with anti-gammadelta TCR antibodies. We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the gammadelta TCR in lymphocytes.
authors.affiliation: The Center for Blood Research, Department of Pediatrics, The Children's Hospital, Boston, MA 02115, USA.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Swat
authors.forename: Ramnik
authors.initials: R
authors.lastname: Xavier
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Emiko
authors.initials: E
authors.lastname: Mizoguchi
authors.forename: Jessica
authors.initials: J
authors.lastname: Fredericks
authors.forename: Keiko
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Atul K
authors.initials: AK
authors.lastname: Bhan
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Alt
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D051567:Proto-Oncogene Proteins c-vav; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D016692:Receptors, Antigen, T-Cell, gamma-delta; C496619:Vav1 protein, mouse