title: Homeostasis in the small intestinal mucosa balanced between cell proliferation and apoptosis is regulated partly by the central nervous system.
abstract: The aim of this study was to investigate whether the central nervous system regulates mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase is a key enzyme for polyamine synthesis, which plays an important role in intestinal mucosal growth. The increase in ornithine decarboxylase activity in the duodenum just before a dark period was abolished by truncal vagotomy. An infusion of 2-deoxy-D-glucose into the third cerebroventricle activated the enzyme activity in the small intestine. Epithelial homeostasis is balanced by the regulation of cell proliferation and cell death. Intestinal mucosal apoptosis decreased in rats with ventromedial hypothalamus lesions, which induced hyperphagia and obesity. In contrast, sustained anorexia induced by 1-deoxy-D-glucosamine increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to the regulation of mucosal homeostasis in the intestinal mucosa.
authors.affiliation: Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Iwakiri
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Takehiro
authors.initials: T
authors.lastname: Fujise
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsunada
authors.forename: Akifumi
authors.initials: A
authors.lastname: Ootani
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000187:drug effects; D006706:Homeostasis / Q000502:physiology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism*; D007421:Intestine, Small; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012680:Sensitivity and Specificity; D014628:Vagotomy
chemical_list: D009955:Ornithine Decarboxylase