title: Eukaryotic translation initiation factors and regulators.
abstract: Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.
authors.affiliation: Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. nahum.sonenberg@mcgill.ca
authors.forename: Nahum
authors.initials: N
authors.lastname: Sonenberg
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Dever
mesh_terms: D001665:Binding Sites; D015852:Eukaryotic Initiation Factor-2 / Q000737:chemistry / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E / Q000737:chemistry / Q000378:metabolism; D039603:Eukaryotic Initiation Factor-4G / Q000235:genetics / Q000378:metabolism; D039642:Eukaryotic Initiation Factors / Q000737:chemistry* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D046911:Macromolecular Substances; D008958:Models, Molecular; D010766:Phosphorylation; D039102:Poly(A)-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000502:physiology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012335:RNA, Ribosomal / Q000737:chemistry*; D012343:RNA, Transfer / Q000737:chemistry* / Q000378:metabolism
chemical_list: D015852:Eukaryotic Initiation Factor-2; D039561:Eukaryotic Initiation Factor-4E; D039603:Eukaryotic Initiation Factor-4G; D039642:Eukaryotic Initiation Factors; D046911:Macromolecular Substances; D039102:Poly(A)-Binding Proteins; D012335:RNA, Ribosomal; D012343:RNA, Transfer