title: Cerebrovascular response in small preterm infants during routine nursery gavage feedings.
abstract: Although gavage feedings are considered a standard of care, they are often accompanied by hemodynamic changes that may have important effects on the cerebral circulation. In 23 premature infants receiving intermittent bolus gavage feeds, changes in cerebral hemodynamics and oxygenation were studied using near-infrared spectroscopy. Orogastric tube insertion resulted in an increased cerebral blood volume in 73% of the infants and in an increase in reduced hemoglobin and in cytochrome AA(3) oxygenase in approximately 66% of the patients. Within 10 min of initiating a gavage feed, cerebral blood volume, oxygenated hemoglobin, reduced hemoglobin, and cytochrome AA(3) oxygenase decreased from baseline in about 60% of the infants. Towards the end of the study, during the postfeeding period, cytochrome AA(3) oxygenase and oxygenated hemoglobin increased in 60%, while reduced hemoglobin decreased in 78% of the infants.
authors.affiliation: Department of Pediatrics and Anesthesia, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Baserga
authors.forename: George A
authors.initials: GA
authors.lastname: Gregory
authors.forename: Augusto
authors.initials: A
authors.lastname: Sola
mesh_terms: D001810:Blood Volume; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003576:Electron Transport Complex IV / Q000097:blood; D004750:Enteral Nutrition; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000502:physiology; D007363:Intensive Care Units, Neonatal; D007440:Intubation; D008297:Male; D010108:Oxyhemoglobins / Q000032:analysis
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D003576:Electron Transport Complex IV