Characterization and role of protozoan parasite proteasomes.
The proteasome, a large non-lysosomal multi-subunit protease complex, is ubiquitous in eukaryotic cells. In protozoan parasites, the proteasome is involved in cell differentiation and replication, and could therefore be a promising therapeutic target. This article reviews the present knowledge of proteasomes in protozoan parasites of medical importance such as Giardia, Entamoeba, Leishmania, Trypanosoma, Plasmodium and Toxoplasma spp.
Paugam
André
A
Laboratoire Signalisation et Parasites (EA 3623), Université Paris 5, C.H.U. Cochin, 27, rue du Faubourg Saint Jacques 75014 Paris, France. andre.paugam@cch.ap-hop-paris.fr
Bulteau
Anne Laure
AL
Dupouy-Camet
Jean
J
Creuzet
Claudine
C
Friguet
Bertrand
B
D000818:Animals; D000981:Antiprotozoal Agents; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D004747:Entamoeba / Q000201:enzymology / Q000502:physiology; D056890:Eukaryota / Q000201:enzymology* / Q000502:physiology; D005872:Giardia / Q000201:enzymology / Q000502:physiology; D007891:Leishmania / Q000201:enzymology / Q000502:physiology; D009097:Multienzyme Complexes / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D010961:Plasmodium / Q000201:enzymology / Q000502:physiology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D046988:Proteasome Endopeptidase Complex; D011528:Protozoan Infections / Q000469:parasitology*; D014122:Toxoplasma / Q000201:enzymology / Q000502:physiology; D014345:Trypanosoma / Q000201:enzymology / Q000502:physiology
D000981:Antiprotozoal Agents; D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex