Adrenergic contribution during acclimatization to high altitude: perspectives from Pikes Peak.
We have examined the sympathoadrenal responses to both acute and chronic high-altitude exposure at the summit of Pikes Peak, CO, in both men and women. A dissociation between the adrenal medullary response (acute) with that of the sympathetic nervous system (chronic) is observed. Both alpha- and beta-adrenergic contributions to key metabolic and physiologic adjustments to high-altitude exposure are evident.
Mazzeo
Robert S
RS
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA. mazzeo@colorado.edu
Reeves
John T
JT
D000064:Acclimatization / Q000502:physiology*; D000531:Altitude; D004734:Energy Metabolism; D004837:Epinephrine / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology*; D012680:Sensitivity and Specificity; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology
D007773:Lactates; D009638:Norepinephrine; D004837:Epinephrine