[Protective effect of total paeony glycoside against cerebral ischemia-reperfusion injury in mice].
OBJECTIVE
To investigate actions of Total Paeony Glycoside (TPG) on cerebral ischemia-reperfusion model in mice.


METHODS
The cerebral ischemia-reperfusion models induced by lagation of bilateral common carotid arteries incompletely were used.


RESULTS
It was found that TPG could improve the learning and memory capacity of model mice in step down test. TPG significantly reduced the decrease of superoxide dismutase(SOD), inhibited the increase of nitric oxide(NO) and lessened the level of malondialdehyde(MDA) in model mice. 75 mg.kg-1 TPG also reduced the decrease of lactate dehydrogenase (LDH) in cerebrum remarkedly.


CONCLUSIONS
It is suggested that TPG possess obvious protective effects against cerebral ischemia-reperfusion mice.
Yang
J
J
Anhui Institute of Medical Sciences, Hefei 230061.
Wang
J
J
Feng
P
P
Li
Y
Y
Ma
C
C
Xu
S
S
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D007859:Learning Disabilities / Q000188:drug therapy; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D029596:Paeonia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D015427:Reperfusion Injury / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D018696:Neuroprotective Agents