[Experimental study of reinforcing effect of bushen yijing capsule on bone quality of cancellous bone in ovariectomy caused rats osteoporosis model].
OBJECTIVE
To explore the influence of Bushen Yijing Capsule (BSYJC) on bone quality of cancellous bone in ovariectomize induced osteoporosis rats model.


METHODS
Forty Wistar female rats, 10 months old, were randomly divided into 4 groups, the normal group, the model control group, the premarin treated and the BSYJC treated group, 10 in each group. The normal group was only sham operated and the other three were ovariectomy performed and treated starting at day 91 postoperationally for consecutively 90 days. Rats were sacrificed at the end of experiment, the second lumbar vertebra was taken out to determine bone density and contents of calcium, phosphorus and organic substances, and the third lumbar vertebra taken out to measure the bone density and biomechanics properties. Bone quality was evaluated with the above indices.


RESULTS
BSYJC could significantly raise the bone density, increase the contents of calcium, phosphorus and organic substances, and improve the biomechanical properties of the lumbovertebral bone in osteoporosis rats.


CONCLUSIONS
BSYJC could improve the bone quality of the cancellous bone in ovariectomized rats.
Zhu
T Y
TY
Luoyang Institute of Traditinonal Chinese Orthopedics and Traumatology of Henan Province, Henan 471002.
Shi
Y Y
YY
Zhang
G
G
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008159:Lumbar Vertebrae / Q000378:metabolism*; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D010052:Ovariectomy; D010710:Phosphates / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D010710:Phosphates; D002118:Calcium