title: A new trick for Cyclin-Cdk: activation of STAT.
abstract: New work in Drosophila demonstrates that cdk4 loss causes phenotypes similar to the loss of JAK/STAT pathway components. Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation.
authors.affiliation: Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Silver
authors.forename: Denise J
authors.initials: DJ
authors.lastname: Montell
mesh_terms: D000818:Animals; D005260:Female; D002453:Cell Cycle / Q000502:physiology; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C495896:Cdk4 protein, Drosophila; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors