title: Interferon-gamma-inducible subunits are incorporated in human brain 20S proteasome.
abstract: In most tissues expressing MHC class I molecules, proteasomes incorporating IFN-gamma-inducible subunits, defined immuno-proteasomes, exist together with constitutive proteasomes. In physiological conditions, the central nervous system expresses neither MHC class I molecules nor TAP1 and TAP2 transporters but besides being constitutive, it is unknown whether immuno-proteasomes are also present in this tissue. We present evidence that in human brain, the two types of proteasome exist suggesting that under physiological conditions, the mechanisms regulating expression of IFN-gamma-inducible subunits as well as of MHC class I molecules and TAP1 and TAP2 transporters in nervous tissue, are not entirely coordinated.
authors.affiliation: Department of Medicine and Experimental Oncology, Section of Biochemistry, University of Turin, Via Michelangelo 27/b, 10126, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Piccinini
authors.forename: Michael
authors.initials: M
authors.lastname: Mostert
authors.forename: Sabrina
authors.initials: S
authors.lastname: Croce
authors.forename: Simone
authors.initials: S
authors.lastname: Baldovino
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Rinaudo
mesh_terms: D017951:Antigen Presentation; D001921:Brain / Q000201:enzymology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008970:Molecular Weight; D009097:Multienzyme Complexes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D021122:Protein Subunits
chemical_list: D009097:Multienzyme Complexes; D021122:Protein Subunits; D007371:Interferon-gamma; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease