title: Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides.
abstract: The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
authors.affiliation: Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, 03550, San Juan de Alicante, Spain. j.saez@umh.es
authors.forename: Javier
authors.initials: J
authors.lastname: Sáez-Valero
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Fodero
authors.forename: Anthony R
authors.initials: AR
authors.lastname: White
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Barrow
authors.forename: David H
authors.initials: DH
authors.lastname: Small
mesh_terms: D000110:Acetylcholinesterase / Q000096:biosynthesis*; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000201:enzymology; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D004622:Embryo, Mammalian; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D010446:Peptide Fragments / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C074636:amyloid beta-protein (25-35); D000110:Acetylcholinesterase