[Oxygen free radical scavening activity and anti-lipid peroxidation of tea polyphenol].
The oxygen free radical scavenging activity and anti-lipid peroxidation of tea polyshenol were studied in vitro. Tea polyphenol possessed significantly scavening effect on hydorxyl radical produced by Fenton recation and superoxide anion produced by xanthine-xanthine oxidase system (IC50 were 919.6 mg/L and 836 mg/L espectively). Tea polyphenol could significantly inhibit the lipid peroxidation of brain omogenate and cerbral mitochondrial membrane induced by hyderxyl radical. The results suggest that the anti-lipid peroxidation of tea polyphenol may be related to its scavenging effects on oxygen free radicals.
Chen
X
X
Guangdong College of Pharmacy, Guangzhou 510224.
He
B
B
D000818:Animals; D001921:Brain / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008861:Microsomes / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D013662:Tea / Q000737:chemistry*
D016166:Free Radical Scavengers; D005609:Free Radicals; D010636:Phenols; D013662:Tea; D013481:Superoxides; D017665:Hydroxyl Radical