title: [Climbing-upward inhibition of Oncomelania hupensis by niclosamide combination].
abstract: OBJECTIVE
  To develop a combination of molluscicide/insecticide with a good molluscicidal effect, especially an inhibitory effect on climbing-upward of Oncomelania hupensis.
  
  
  METHODS
  Experiments on molluscicidal and snail-climbing inhibition effect of the combination of niclosamide and shachongding [(dimethylamine) trithacyclohexane hydrochloride] were conducted by immersion and spraying in laboratory.
  
  
  RESULTS
  The combination of niclosamide (0.2 mg/L) and shachongding (0.1 mg/L) showed an inhibition of 92.67% of snails to climb up. There was no significant difference in molluscicidal effect between the combination (LC90 0.198 mg/L) and niclosamide alone (LC90 0.207 mg/L).
  
  
  CONCLUSIONS
  The combination showed an effective inhibition on the climbing-upward of snails in water so as to improve the molluscicidal effect and reduce the cost of mollusciciding.
authors.affiliation: Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025.
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: F X
authors.initials: FX
authors.lastname: Xie
authors.forename: Z P
authors.initials: ZP
authors.lastname: Bao
authors.forename: D B
authors.initials: DB
authors.lastname: Zhu
authors.forename: C H
authors.initials: CH
authors.lastname: Ni
mesh_terms: D000818:Animals; D004123:Dimethylamines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008975:Molluscacides / Q000494:pharmacology*; D009534:Niclosamide / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*
chemical_list: D004123:Dimethylamines; D008975:Molluscacides; D009534:Niclosamide; C034516:dimethylamine