title: Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas.
abstract: An unusual course was observed in a patient with indolent T-prolymphocytic leukaemia (T-PLL) who subsequently developed mycosis fungoides (Mf), lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL). Polymerase chain reaction analysis demonstrated identical monoclonal T-cell receptor-beta and -gamma gene rearrangements in all the different clinical entities. Furthermore, cytogenetic studies revealed the same aberrant clone with trisomy of chromosome 8 in T-PLL and ALCL cells. This unique observation suggests that in T-PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T-cell lymphoma.
authors.affiliation: Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany. assaf@zedat.fu-berlin.de
authors.forename: Chalid
authors.initials: C
authors.lastname: Assaf
authors.forename: Michael
authors.initials: M
authors.lastname: Hummel
authors.forename: Edgar
authors.initials: E
authors.lastname: Dippel
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwartz
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Geilen
authors.forename: Lana
authors.initials: L
authors.lastname: Harder
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.forename: Matthias
authors.initials: M
authors.lastname: Steinhoff
authors.forename: Claus-Detlev
authors.initials: CD
authors.lastname: Klemke
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thiel
authors.forename: Sergij
authors.initials: S
authors.lastname: Goerdt
authors.forename: Harald
authors.initials: H
authors.lastname: Stein
authors.forename: Constantin E
authors.initials: CE
authors.lastname: Orfanos
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*