title: The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in human breast cancers.
abstract: Ras-GTPase activating protein SH3 domain-binding proteins 1 and 2 (G3BP1 and G3BP2) have recently been reported to be encoded by two separate genes on human chromosomes 5 and 4 respectively and have been implicated in Ras signalling, NFkappaB signalling, the ubiquitin proteosome pathway and RNA processing. In addition, G3BP1 has recently been implicated in cancer biology. The transcripts for these genes have been shown to be universally expressed; however, this is not the case for the proteins which appear to be tissue and cell type specific. We report here the expression of G3BP1 and 2 in human breast cancers and present the first data showing that G3BP2 expression is specific in human breast cancer tissue and was over-expressed in 88% of tumours examined (n = 58).
authors.affiliation: Institute for Molecular Bioscience, University of Queensland, St. Lucia, 4072, Australia.
authors.forename: Juliet
authors.initials: J
authors.lastname: French
authors.forename: Renée
authors.initials: R
authors.lastname: Stirling
authors.forename: Michael
authors.initials: M
authors.lastname: Walsh
authors.forename: Hendrick Daniel
authors.initials: HD
authors.lastname: Kennedy
mesh_terms: D016475:3T3 Cells / Q000378:metabolism / Q000473:pathology; D000818:Animals; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000737:chemistry / Q000378:metabolism* / Q000556:secondary; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000378:metabolism / Q000556:secondary; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry / Q000378:metabolism / Q000556:secondary; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000378:metabolism / Q000556:secondary; D002352:Carrier Proteins / Q000032:analysis / Q000378:metabolism*; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D004265:DNA Helicases; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D051379:Mice; D000075223:Poly-ADP-Ribose Binding Proteins; D020365:RNA Helicases; D000067776:RNA Recognition Motif Proteins
chemical_list: D002352:Carrier Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D000067776:RNA Recognition Motif Proteins; D004265:DNA Helicases; C116070:G3BP1 protein, human; C492055:G3bp1 protein, mouse; D020365:RNA Helicases