title: Neuroleptic malignant syndrome in Kufs' disease.
abstract: A patient with adult neuronal ceroid lipofuscinosis (ANCL; Kufs' disease) is described in whom neuroleptic malignant syndrome occurred, initially presenting as catatonic syndrome. Comprehensive neuroimaging studies were conducted including FDG-PET, IBZM-SPECT, and beta-CIT-SPECT, electrophysiological examinations and an ex vivo contracture test exposing muscle biopsy specimens to neuroleptics. Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL.
authors.affiliation: Department of Psychiatry and Psychotherapy, Julius-Maximilians-University Würzburg, Germany. a.reif@gmx.net
authors.forename: A
authors.initials: A
authors.lastname: Reif
authors.forename: M F
authors.initials: MF
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Hoyer
authors.forename: C
authors.initials: C
authors.lastname: Schneider-Gold
authors.forename: A J
authors.initials: AJ
authors.lastname: Fallgatter
authors.forename: W
authors.initials: W
authors.lastname: Roggendorf
authors.forename: B
authors.initials: B
authors.lastname: Pfuhlmann
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001706:Biopsy; D003131:Combined Modality Therapy; D003286:Contracture / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000209:etiology / Q000503:physiopathology*; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications*; D011618:Psychotic Disorders / Q000628:therapy
chemical_list: D014150:Antipsychotic Agents