[Hypocholesterolemic effect of total isoflavones from Pueraria lobata in ovariectomized rats].
OBJECTIVE
To observe the effects of total isoflavones from Pueraria lobata (TIP) on lipid metabolism in estrogen deficient rat.


METHODS
Female SD rats were bilaterally ovariectomized under anesthesia. TIP was administrated orally for 7 months. Serum lipids were determined at 1.5, 4.0 and 7.0 months, and liver lipids were detected at 7 months.


RESULTS
Compared with non-ovariectomized rats, serum TC level and the ration of TC/HDL-C in ovariectomized rats were obviously increased while HLD-C was slightly induced and TG level were changeless. In TIP-treated groups, serum TC level and the ratios of TC/HDL-C were markedly lowered than those in OVX group, while HDL-C slightly increased. TG level were much reduced in 1.5 month and changeless in 4.0 and 7.0 month. Slightly increase of cholesterol and markedly induction of triglyceride tissue were observed in liver.


CONCLUSIONS
TIP significantly decreased concentrations of serum TC and liver TG in OVX rats.
Zheng
Gaoli
G
Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
Zhang
Xinyue
X
Zheng
Jingwei
J
Gong
Weigui
W
Zheng
Xiaoxiang
X
Chen
Anli
A
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D004964:Estriol / Q000494:pharmacology; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D007529:Isoflavones; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D004964:Estriol