title: Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model.
abstract: Nonhuman primates are being used increasingly as a non-rodent animal model during preclinical toxicology and safety assessment on the basis of proven similarity and comparability between nonhuman primates and humans. The validity of the nonhuman primate models applies to many aspects of toxicological testing and holds particularly true for the evaluation of reproductive toxicology and developmental toxicology. More recently, the advent of humanized antibodies and vaccines imposed further demand on nonhuman primate models since many immunotherapeutics do not interact with rodent receptors but frequently only cross-react with primate tissue. In this paper we discuss the suitability of primate models for reproductive, developmental and immunotoxicology testing, and present our initial data on the development of lymphatic organs and immune system in a nonhuman primate model.
authors.affiliation: Covance Laboratories GmbH, Kesselfeld 29, 48163 Münster, Germany.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Buse
authors.forename: Gunnar
authors.initials: G
authors.lastname: Habermann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Osterburg
authors.forename: Rainhart
authors.initials: R
authors.lastname: Korte
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Weinbauer
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000276:immunology*; D000818:Animals; D005260:Female; D000922:Immunotoxins / Q000633:toxicity*; D008208:Lymphatic System / Q000187:drug effects / Q000196:embryology; D011247:Pregnancy; D011323:Primates / Q000276:immunology / Q000502:physiology*; D012098:Reproduction / Q000187:drug effects*
chemical_list: D000922:Immunotoxins