[Synthesis and antibacterial activities of 3,6-disubstituted-5,6-dihydrogen-1,2,4-s-triazolo-[3,4-b]-1,3,4-thiadiazoles].
OBJECTIVE
To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings.


RESULTS
Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1, 2, 4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities.


CONCLUSIONS
The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.
Shi
H J
HJ
Department of Chemistry, Nanjing University, Nanjing 210093, China.
Wang
Z Y
ZY
Shi
H X
HX
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013830:Thiadiazoles; D014230:Triazoles