Functional and structural comparison of PXR and CAR.
The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.
Moore
John T
JT
Nuclear Receptor Discovery Research, GlaxoSmithKline, 5 Moore Drive, V116-1b, Research Triangle Park, NC 27709, USA. jtm36008@gsk.com
Moore
Linda B
LB
Maglich
Jodi M
JM
Kliewer
Steve A
SA
D000818:Animals; D000090702:Constitutive Androstane Receptor; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism*; D011987:Receptors, Steroid / Q000737:chemistry* / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
D000090702:Constitutive Androstane Receptor; D008024:Ligands; C000625852:NR1I2 protein, human; C000716327:NR1I3 protein, human; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors