Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials.
A spectrum of pneumococci with varying susceptibilities to beta-lactams, macrolides and quinolones was tested for susceptibility to nine antibiotics, including the novel lipopeptide daptomycin. Daptomycin was active against all strains (MIC range </=0.5 mg/L; MIC(50) 0.125 mg/L; MIC(90) 0.25 mg/L). All pneumococci were susceptible to vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin, with MICs < 4.0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h.
Pankuch
Glenn A
GA
Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
Jacobs
Michael R
MR
Appelbaum
Peter C
PC
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D017576:Daptomycin / Q000494:pharmacology*; D007769:Lactams; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013997:Time Factors
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007769:Lactams; D018942:Macrolides; D017576:Daptomycin