[Morphological, cytogenetic and molecular biological characteristics of lung cancer in persons exposed for a long time to radionuclide radiation pollution in the Semipalatinsk region of Kazakhstan].
Surgical and biopsy material was used from 57 patients with lung carcinoma (LC): 17 patients (group I) lived close to testing area from the childhood to 1993 and were exposed to radiation at the year dose 0.1 ber. For comparison surgical and biopsy material from 40 patients (group 2) was taken who lived in the territories of Kazakhstan (10 patients) and Moscow (30 patients) with normal radiation background. The following features of LC were found in the groups in question: constant observation of dust particles and interstitial and focal fibrosis in tumours of various localization and histological type; prevailing small cell carcinoma as compared to other histological types; high frequency of nonsmall cell lung carcinoma; higher expression of IGFII, IGFBP1,2 and rare expression of IGFB3; proliferative activity followed by an increased expression of c-myc, bcl-2.
Kogan
E A
EA
I. M. Sechenov Moscow Medical Academy, 119881, Moscow.
Sagindikova
G S
GS
Sekamova
S M
SM
Jack
G
G
D000398:Air Pollution, Radioactive; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D002455:Cell Division / Q000528:radiation effects; D015870:Gene Expression; D006801:Humans; D007623:Kazakhstan; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D009031:Moscow; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000209:etiology
D014408:Biomarkers, Tumor