title: DNA manipulators: caught in the act.
abstract: DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.
authors.affiliation: Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, IL 60208-3500, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Changela
authors.forename: Kay
authors.initials: K
authors.lastname: Perry
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Taneja
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mondragón
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004265:DNA Helicases / Q000737:chemistry / Q000378:metabolism; D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000378:metabolism; D026942:DNA Topoisomerases / Q000737:chemistry / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000378:metabolism; D019426:Integrases / Q000737:chemistry* / Q000378:metabolism; D007535:Isomerases / Q000737:chemistry* / Q000378:metabolism; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D011487:Protein Conformation; D045522:Recombinases; D011995:Recombination, Genetic; D019895:Transposases / Q000737:chemistry / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D045522:Recombinases; D004247:DNA; D004254:DNA Nucleotidyltransferases; D019426:Integrases; D019895:Transposases; D004265:DNA Helicases; D007535:Isomerases; D026942:DNA Topoisomerases; C041813:DNA reverse gyrase; D004264:DNA Topoisomerases, Type I