Cutaneous metastatic malignant fibrous histiocytoma.
Malignant fibrous histiocytoma is the most common soft tissue sarcoma, but cutaneous metastasis of this tumor is quite rare. A 30-year-old female patient had several brownish 0.5 x 0.5-cm papules on her right ankle. Histopathologic examination revealed spindle-shaped tumor cells with cellular pleomorphism and high mitosis (5 of 10 high-power fields), suggestive of malignant fibrous histiocytoma. She had a history of left subcutaneous breast mass that was diagnosed as malignant fibrous histiocytoma 3 years earlier. We report a case of malignant fibrous histiocytoma with pleomorphism mixed with spindle-shaped cells and multinuclear giant cells, which metastasized to the skin.
Lew
Wook
W
Departments of Dermatology, Yonsei University College of Medicine, Seoul, Korea. wlewderm@yumc.yonsei.ac.kr
Lim
Ha Seong
HS
Kim
You Chan
YC
D000328:Adult; D000842:Ankle / Q000473:pathology; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000378:metabolism / Q000556:secondary*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule