Vasopressin receptor 1a-mediated negative regulation of B cell receptor signaling.
We report here a study of T and B cell development and function in mice with disruption of the vasopressin receptor 1a (v1a) gene. Loss of the v1a receptor caused a shift from IgM(high)/IgD(high) to the more mature IgM(low)/IgD(high) B cells, a significantly greater extent of splenic B cells proliferation in response to anti-IgM stimulation, and enhanced IgG1 and IgG2b production in response to immune challenge with T-dependent antigen. B-1 cells were increased in v1a(-/-) mice. In contrast, T cell differentiation and activation were normal in v1a(-/-) mice. Our data identify a novel function for v1a in the periphery as a negative regulator of B cell receptor (BCR) signaling. These data suggest that in addition to its other stress-related effects, vasopressin may also serve as a counter-regulatory restraint upon the immune system during fight or flight situations.
Hu
Shuang-Bao
SB
Clinical Neuroendocrinology Branch, National Institute of Mental Health, NIH, 10 Center Drive, 10/2D46, Bethesda, MD 20892, USA. sbh@codon.nih.gov
Zhao
Zi-Shan
ZS
Yhap
Christine
C
Grinberg
Alex
A
Huang
Sing-Ping
SP
Westphal
Heiner
H
Gold
Philip
P
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D007136:Immunoglobulins / Q000097:blood; D008213:Lymphocyte Activation; D038041:Lymphopoiesis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D017483:Receptors, Vasopressin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology
D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell; D017483:Receptors, Vasopressin