title: Effects of hydroxyapatite in combination with far-infrared rays on spontaneous mammary tumorigenesis in SHN mice.
abstract: We have found that the administration of a diet containing 5% hydroxyapatite (HAP) derived from pig and cattle bones, and exposure to far-infrared rays (FIR) markedly inhibited spontaneous mammary tumorigenesis in SHN mice. Thus, the effect of combined treatment with HAP and FIR on mammary tumorigenesis was examined. The significant inhibition of tumor development by individual treatment with HAP or FIR was not enhanced by combined treatment; instead, the decrease in the inhibitory effect of HAP with age was ameliorated. Associated with this, life span was elongated and a decline in ovarian function was prevented by HAP plus FIR. Normal and preneoplastic growth of mammary glands and plasma component levels were not significantly affected by any treatment. The findings indicate that HAP and FIR have characteristics common to most natural products; in combination with other agents, they have little additive effect, when each is highly active.
authors.affiliation: Experimental Animal Research Laboratory, Meiji University, Kawasaki, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Udagawa
authors.forename: Harumichi
authors.initials: H
authors.lastname: Ishigame
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagasawa
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D004032:Diet; D004326:Drinking / Q000187:drug effects / Q000528:radiation effects; D017886:Durapatite / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects / Q000528:radiation effects; D005164:Factor IX / Q000032:analysis; D005260:Female; D007259:Infrared Rays; D008136:Longevity; D008325:Mammary Neoplasms, Experimental / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011230:Precancerous Conditions / Q000473:pathology; D016019:Survival Analysis
chemical_list: D005164:Factor IX; D017886:Durapatite