[Acute non-cardiogenic pulmonary edema secondary to hydrochlorothiazide therapy].
Several commonly prescribed drugs can cause acute non-cardiogenic pulmonary edema. A cause-effect relationship is usually difficult to establish because symptoms are not specific. We report a case of pulmonary edema induced by a common diuretic, hydrochlorothiazide. This complication can occur after a first dose of the drug or in patients who have been taking it with no side effects. Edema is due to an idiosyncratic reaction rather than an immune response. The clinical course is usually favorable over the first 24 hours with treatment of blood pressure and respiratory support. Given that severity increases with recurrence, we underline the importance of diagnosis in the first episode.
Jara Chinarro
B
B
Servicio de Neumología. Hospital Universitario de Getafe. Getafe. Madrid. Spain. beat1089@separ.es
de Miguel Díez
J
J
García Satue
J L
JL
Juretschke Moragues
M A
MA
Serrano Iglesias
J A
JA
D000208:Acute Disease; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced; D004232:Diuretics; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D005483:Flushing / Q000139:chemically induced; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D004656:Enalapril