Synthesis, characterization and antitumor studies of Mn(II), Ni(II), Cu(II) and Zn(II) complexes of N-nicotinoyl-n'-o-hydroxythiobenzhydrazide.
A new ligand N-Nicotinoyl-N'-o-hydroxythiobenzhydrazide (H2Notbh) forms complexes [Mn(Notbh)(H2O)], [M(Notbh)] [M = Ni(II) Cu(II) and Zn(II)] which were characterized by various physico-chemical techniques. All the metal complexes were observed to inhibit the growth of tumor in vitro, whereas, ligand did not. In vivo administration of these complexes resulted in prolongation of survival of tumor bearing mice. Tumor bearing mice administered with metal complexes showed reversal of tumor growth associated induction of apoptosis in lymphocytes. The paper discusses the possible mechanisms and therapeutic implication of the H2Notbh and its metal complexes in tumor regression and tumor growth associated immunosuppression.
Shrivastav
Anuraag
A
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.
Singh
Nand Kishore
NK
Singh
Sukh Mahendra
SM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006834:Hydrazines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008345:Manganese / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015996:Survival Rate; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D006834:Hydrazines; C479551:N-nicotinoyl-n'-o-hydroxythiobenzhydrazide; D009942:Organometallic Compounds; D008345:Manganese; D003300:Copper; D009532:Nickel; D015032:Zinc