Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using chiral spiro phosphoramidites as ligands.
Novel monodentate chiral spiro phosphoramidite ligands have been readily synthesized in good yields from enantiomerically pure 1,1'-spirobiindane-7,7'-diol. The new ligands were highly efficient in the copper-catalyzed conjugate addition of Et(2)Zn to enones with up to 98% enantiomeric excess.
Zhou
Hai
H
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, PR China.
Wang
Wen-Hu
WH
Fu
Yu
Y
Xie
Jian-Hua
JH
Shi
Wen-Jian
WJ
Wang
Li-Xin
LX
Zhou
Qi-Lin
QL