title: [The expression of collagen type I and type II during the second fracture healing].
abstract: OBJECTIVE
  This study was conducted to disclose the rules of collagen type I and II production and hence to acquire knowledge about the mechanism of repairing during the second period of fracture healing.
  
  
  METHODS
  An experimental model of second fracture healing at rat's femurs was used to study the production of collagen type I and II by means of immunohistochemistry; meanwhile the histologic changes were observed with the use of HE staining and Alcian blue staining at 3 days, 1, 2, 3, 4 weeks postoperatively.
  
  
  RESULTS
  The expression of both collagen type I and II was detected by immunohistochemistry at 1 week. The peak expression of collagen type II occurred at 3 weeks. The higher expression of collagen type I was observed at 4 weeks.
  
  
  CONCLUSIONS
  The morphologic changes of chondrocyte and the production of collagen type I and II by chondrocyte in cartilage callus are correlated with their repairing function during different periods of fracture healing.
authors.affiliation: Department of Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Jiang
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Li
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000737:chemistry; D024042:Collagen Type I / Q000032:analysis*; D024043:Collagen Type II / Q000032:analysis*; D005264:Femoral Fractures / Q000378:metabolism* / Q000503:physiopathology; D017102:Fracture Healing; D008297:Male; D051381:Rats
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II