A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5.
BACKGROUND
Castleman's disease (CD), idiopathic lymph-node hyperplasia, is a heterogeneous disease of unknown origin. Although the pathophysiology is yet to be elucidated, interleukin (IL)-6 produced by swollen lymph nodes has been reported to play a crucial role in CD.


METHODS
This report presents a case of a 37-yr-old man with CD showing marked elevation of IL-6, hypereosinophilia, and also IL-5 elevation. To date, IL-5 has not been reported to influence CD. However, because in this case the serum concentration of IL-5 produced from swollen lymph nodes paralleled the general symptoms, IL-5, in addition to IL-6, may have played an important role in the disease.


CONCLUSIONS
Although in CD the serum IL-5 level is generally within the normal range, mild eosinophilia is a common complication of the disease. This case indicates that IL-5 can also influence eosinophilia. Taken together, this suggests that there may be a more general association between local production of IL-5 and the pathology of CD.
Ishii
Taeko
T
Division of Internal Medicine, Kinki Central Hospital, Itami City, Hyogo, Japan. ishiit@imed3.med.osaka-u.ac.jp
Tatekawa
Toyoshi
T
Koseto
Masahiro
M
Ishii
Masaru
M
Kobayashi
Hideyuki
H
Koike
Masato
M
Fujii
Takashi
T
Saeki
Yukihiko
Y
D000328:Adult; D005871:Castleman Disease / Q000097:blood / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000097:blood / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology
D015848:Interleukin-5; D015850:Interleukin-6