title: Detection of metallic implant-associated infections with FDG PET in patients with trauma: correlation with microbiologic results.
abstract: OBJECTIVE
  To prospectively evaluate the value of positron emission tomography (PET) with fluorine 18 fluorodeoxyglucose (FDG) in the detection of metallic implant-associated infections in patients with trauma.
  
  
  METHODS
  Twenty-nine partial-body FDG PET scans in 22 patients suspected of having metallic implant-associated infections were obtained prior to surgery. In two of the 22 patients, data were acquired with a combined PET-CT in-line system. Soft-tissue and bone infections were evaluated. PET scans were analyzed by two experienced nuclear medicine physicians first separately and then in consensus. Disease status was defined on the basis of the results of microbiologic evaluation of surgical specimens together with intraoperative findings. Sensitivities, specificities, accuracies, interobserver variability (determination of kappa values), and receiver operating characteristic curves were obtained.
  
  
  RESULTS
  Of 29 PET scans, 14 were true-positive, 14 were true-negative, and one was false-positive. Sensitivity, specificity, and accuracy were 100%, 93.3%, and 97%, respectively, for all PET data; 100%, 100%, and 100%, respectively, for the central skeleton; and 100%, 87.5%, and 95%, respectively, for the peripheral skeleton. The degree of overall interobserver concordance was high (kappa = 0.96).
  
  
  CONCLUSIONS
  FDG PET appears to be a sensitive and specific method for the detection of infectious foci due to metallic implants in patients with trauma.
authors.affiliation: Department of Surgery, Division of Trauma Surgery, University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland.
authors.forename: Marc
authors.initials: M
authors.lastname: Schiesser
authors.forename: Katrin D M
authors.initials: KD
authors.lastname: Stumpe
authors.forename: Otmar
authors.initials: O
authors.lastname: Trentz
authors.forename: Thomas
authors.initials: T
authors.lastname: Kossmann
authors.forename: Gustav K
authors.initials: GK
authors.lastname: Von Schulthess
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging*; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed
chemical_list: D008670:Metals; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18