Carcinosarcoma of the stomach.
In the gastrointestinal tract, carcinosarcomas are most frequently seen in the esophagus. Carcinosarcoma in the stomach is a rare tumor. We report a carcinosarcoma of the antrum of stomach. The tumor was polypoid and exophytic in appearance and located in the antrum. Immunohistochemical studies showed positivity for cytokeratin, epithelial membrane antigen and cytoplasmic carcinoembryonic antigen in the epithelial component. Positive staining with vimentin, desmin and focal smooth muscle actin and negative staining with chromogranin were observed in spindle cells. Nuclear positive staining was observed with p53 and Ki-67 in both glandular and spindle atypical cells.
Kayaselcuk
Fazilet
F
Department of Pathology, Baskent University Faculty of Medicine, Yüregir, Adana, 01250, Turkey. faziletks@yahoo.com
Tuncer
Ilhan
I
Toyganözü
Yavuz
Y
Bal
Nebil
N
Ozgür
Gürsel
G
D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery*; D003893:Desmin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D013276:Stomach Ulcer / Q000473:pathology / Q000601:surgery
D003893:Desmin