An intramolecular spin of the LDL receptor beta propeller.
Study of the LDL receptor as a model system has led to insights into general principles underlying receptor-mediated endocytosis of bound ligands. The recently published structure of the entire LDL receptor ectodomain, determined at pH 5.3, now suggests an elegant model to explain how lipoprotein ligands are released from the receptor by exposure to the low-pH environment of the endosome.
Jeon
Hyesung
H
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Blacklow
Stephen C
SC
D001665:Binding Sites; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D017434:Protein Structure, Tertiary; D011973:Receptors, LDL / Q000378:metabolism*
D008024:Ligands; D011973:Receptors, LDL