The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.
Maurer-Stroh
Sebastian
S
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Dickens
Nicholas J
NJ
Hughes-Davies
Luke
L
Kouzarides
Tony
T
Eisenhaber
Frank
F
Ponting
Chris P
CP
D000595:Amino Acid Sequence; D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D006801:Humans; D019476:Insect Proteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
D029721:Drosophila Proteins; D019476:Insect Proteins; D026901:Membrane Transport Proteins; D010940:Plant Proteins; C071597:tud protein, Drosophila