title: Loss of anterior chamber-associated immune deviation during normal pregnancy in primates.
abstract: OBJECTIVE
  We recently found that loss of anterior chamber-associated immune deviation was associated with normal pregnancy in rabbits. The purpose of this study is to further investigate whether the same events occurred in nonhuman primates.
  
  
  METHODS
  Mid-pregnant cynomolgus monkeys were randomly selected. Bovine serum albumin (BSA) was inoculated in anterior chamber of eyes of nonpregnant and mid-pregnant monkeys that were subsequently immunized with BSA in adjuvant. Delayed-type hypersensitivity (DTH) was assessed by skin challenge.
  
  
  RESULTS
  Non-pregnant monkeys of intracameral BSA proved able to acquire antigen-specific suppression of delayed-type hypersensitivity. By contrast, inoculation of BSA to anterior chamber of pregnant monkeys abolished the DTH-suppression effect.
  
  
  CONCLUSIONS
  This is the first demonstration in primates that loss of anterior chamber-associated immune deviation occurred during normal pregnancy. The fluctuations of systemic hormone levels during normal pregnancy might influence local immunoregulation within the eye.
authors.affiliation: Research Section of Ophthalmology, Institute of Tissue Transplantation & Immunology, Jinan University, Guangzhou 510632, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Peng
authors.forename: C
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology*; D000917:Antibody Formation; D002417:Cattle; D005260:Female; D006968:Hypersensitivity, Delayed; D007109:Immunity; D008252:Macaca fascicularis; D011247:Pregnancy; D011817:Rabbits; D011897:Random Allocation; D012710:Serum Albumin, Bovine / Q000276:immunology*
chemical_list: D012710:Serum Albumin, Bovine