[Multicenter evaluation on the efficacy and safety of sparfloxacin in the treatment of acute bacterial infections].
OBJECTIVE
To evaluate the efficacy and safety of domestic sparfloxacin.


METHODS
A multicentre randomized controlled clinical trial was conducted to compare sparfloxacin versus ofloxacin in the treatment of acute bacterial infections. 58 patients received 200 mg of sparfloxacin once daily intravenous drip and 61 patients received 200 mg of ofloxacin twice daily intravenous drip. Both drugs were given for 7-14 days.


RESULTS
The clinical cure rates of sparfloxacin group and ofloxacin group were 44.83% and 42.62%, and the efficacy rates were 87.93% and 81.97%, respectively; no significant differences were noted between the two groups (P > 0.05). The bacterial eradication rates were 86.00% and 84.62% respectively (P > 0.05). The adverse reactions in the two groups were 13.79% and 22.58% (P > 0.05). Photosensitivity reaction was not observed in this study.


CONCLUSIONS
Domestic sparfloxacin is effective and safe in treating acute bacterial infections.
Cai
Yongning
Y
National Base for Drug Clinical Trial, West China Hospital, Sichuan University, Chengdu 610041, China.
Liang
Derong
D
Xu
Nan
N
Miao
Jia
J
Qiu
Dungong
D
Wen
Chonglin
C
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015242:Ofloxacin; C061363:sparfloxacin