[Effect of propylene glycol mannate sulfate on blood lipids and lipoprotein lipase in hyperlipidemic rat].
OBJECTIVE
To study the effect of propylene glycol mannate sulfate (PGMS) on blood lipids and lipoprotein lipase in hyperlipidemic rat, and its anti-hyperlipidemic mechanism.


METHODS
PGMS was administered ig at different doses (37.8 mg.kg-1.d-1 and 75.6 mg.kg-1.d-1) to hyperlipidemic rats for three weeks and blood serum was obtained after starved 12 h. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were examined. The mRNA expression of lipoprotein lipase (LPL) in liver, spleen and artery was detected by reverse transcription polymerase chain reaction (RT-PCR).


RESULTS
PGMS significantly decreased the levels of TC, TG and LDL-C and increased that of HDL-C in hyperlipidemic serum dose-dependently. PGMS was shown to increase the level of LPL mRNA expression, which is related directly to the controlling effects of PGMS on blood lipids.


CONCLUSIONS
PGMS modulated blood lipids by promoting mRNA expression of LPL. This may be one important mechanism of PGMS to modulate blood lipids.
Gao
Yan
Y
Institute of Marine Drugs and Foods, Ocean University of Qingdao, Qingdao 266003, China.
Yu
Wen-gong
WG
Han
Feng
F
Lu
Xin-zhi
XZ
Gong
Qian-hong
QH
Hu
Xiao-ke
XK
Guan
Hua-shi
HS
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D011409:Propylene Glycols / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000096:biosynthesis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D011409:Propylene Glycols; D012333:RNA, Messenger; D014280:Triglycerides; D008071:Lipoprotein Lipase