[Association between the excretion levels of urinary TNOC and NAAs in the inhabitants of high and low risk area for esophageal cancer in southern China].
To assess the role of urinary total N-nitroso compounds(TNOC) index in study etiology of N-nitroso compounds(NOC) of esophageal cancer in southern China and to study the association between TNOC index and traditional indexes of N-nitrosamino acids(NAAs). The samples of 12-hr overnight urine were collected from 120 male adults in high-risk area (Nanao county) and low-risk area(Lufeng county) for esophageal cancer. The 240 male healthy subjects(35-64 years old) were selected by a 3-stage random cluster sample procedure. Levels of TNOC and 4 categories of NAAs were measured in samples. The results showed that Urinary TNOC contents were positively correlated with esophageal cancer mortality in the south(rs = 0.25, P < 0.05). Only 7.5% content of urinary TNOC came from the 4 categories of NAAs in the high-risk area when 57% content of urinary TNOC came from the NAAs in the low-risk area. The urinary NOC components in the high-risk area were more complex than the components in the low-risk area. Urinary TNOC is a better index that is applied to assess the exposure dose of TNOC in humans and study etiology of NOC of esophageal cancer. When the categories of NOC in urine are less, TNOC index is correlated with NAAs indexes. The results imply that TNOC are implicated in the etiology of esophageal cancer in southern China.
Lin
Kun
K
Shantou University Medical College, Shantou 515031, China.
Shen
Wenying
W
Wu
Yongning
Y
D000328:Adult; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009602:Nitrosamines / Q000652:urine*; D009603:Nitroso Compounds / Q000652:urine*; D012307:Risk Factors
D009602:Nitrosamines; D009603:Nitroso Compounds