title: Choroidal vascular lesions identified by ICG angiography in a case of familial amyloidotic polyneuropathy.
abstract: BACKGROUND
  To describe a patient with familial amyloidotic polyneuropathy (FAP) whose choroidal vascular lesions were demonstrated dynamically with the use of indocyanine green (ICG) angiography.
  
  
  METHODS
  A 59-year-old man complained of blurred vision due to vitreal amyloidosis in both eyes. Fundus examination after pars plana vitrectomy showed multiple retinal hemorrhages.
  
  
  METHODS
  ICG angiography performed after vitrectomy clearly delineated multiple sites of hyperfluorescence indicating tissue staining alongside the major choroidal veins in the lower fundus of his left eye. ICG hyperfluorescence was more evident in the late angiographic phase. Fundus examination and fluorescein angiography revealed no abnormal findings at the corresponding sites of ICG dye leakage.
  
  
  CONCLUSIONS
  Choroidal vascular lesions in eyes with FAP were demonstrated in vivo using ICG angiography for the first time. ICG angiography may be very beneficial to evaluate occult choroidal involvement in patients with FAP.
authors.affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ariko
authors.initials: A
authors.lastname: Kojima
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohno-Matsui
authors.forename: Tamaki
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Shizuko
authors.initials: S
authors.lastname: Ichinose
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nemoto
authors.forename: Takumi
authors.initials: T
authors.lastname: Akashi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Eishi
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Akira
authors.initials: A
authors.lastname: Hirose
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000175:diagnosis*; D002829:Choroid / Q000098:blood supply*; D004396:Coloring Agents; D005128:Eye Diseases / Q000175:diagnosis*; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D014680:Veins; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green