title: [Immunopathogenesis of severe wounds and traumas: possibilities of immune correction].
abstract: The authors describe the present-day views on the nature of immune dysfunctions in severe traumas. Based on personal clinical experiences and literature data the authors discuss the role of immune dysfunctions in pathogenesis of the traumatic disease. Special attention is given to the role of the immune system in the development of the life-threatening condition: polyorganic insufficiency whose formation mainly results from disorganization and functional failure of the system of immune reactivity. Clinical investigations have shown high effectiveness of early administration for severe wounds and traumas of a new means of immunocorrection--yeast recombinant interleukin-2 of man (preparation Roncoleukin). The administration of this immunocorrector in complex schemes of intensive therapy of the victims was shown to prevent the development of severe pyo-septic pathology and perfectly change the course of the traumatic disease.
authors.forename: V F
authors.initials: VF
authors.lastname: Lebedev
authors.forename: V K
authors.initials: VK
authors.lastname: Kozlov
authors.forename: S V
authors.initials: SV
authors.lastname: Gavrilin
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000276:immunology; D010919:Placebos; D018805:Sepsis / Q000209:etiology / Q000276:immunology; D012774:Shock, Traumatic / Q000209:etiology / Q000276:immunology; D014947:Wounds and Injuries / Q000150:complications / Q000276:immunology* / Q000401:mortality / Q000628:therapy*
chemical_list: D007376:Interleukin-2; D010919:Placebos