[Experimental study on liver protective effect of Artemisia rupestris extract].
OBJECTIVE
To explore the protective effect of Artemisia rupestris extract (ARE) on chemical liver injury and immunological hepatitis.


METHODS
Mice model of immunological hepatitis was established by lipopolysaccharide plus Bacillus Calmette-Guérin vaccine (BCG), and the models of liver injury was induced by D-galactosamine or carbon tetrachloride (CCl4) in mice and rats. The effects of ARE in preventing and treating immunological hepatitis and protecting liver injury were observed.


RESULTS
ARE significantly lowered the serum alanine transaminase (ALT) in immunological hepatitis (P < 0.05), CCl4 induced liver injury model mice and rats (P < 0.01), and in D-galactosamine induced liver injury mice (P < 0.05).


CONCLUSIONS
ARE has significantly protective effect against chemical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.
Israpil
Institute of Traditional Uighur Medicine of Xinjiang, Urumqi 830001.
Abdiryim
Gulnar
D000818:Animals; D019306:Artemisia / Q000737:chemistry; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005690:Galactose; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D005690:Galactose