Ethnic differences at risk for gestational trophoblastic disease in New Mexico: A 25-year population-based study.
OBJECTIVE
The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data.


METHODS
All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor Registry and Vital Records and Health Statistics Annual Reports. Statistical methods included trends analyses, odds ratios, and Poisson regression.


RESULTS
Of 939 total cases, 312 non-Hispanic white women, 399 Hispanic white women, 201 American Indian women, and 27 other women were affected. Age-adjusted incidence rates were significantly higher for American Indian women (11.16%) compared with non-Hispanic (3.57%) or Hispanic white women (5.32%); the probability value was <.001. When live birth (1:438 women) and pregnancy (1:486 women) denominators were considered, American Indian women alone were at increased risk, and the ratio increased by 56% over 25 years. American Indian women were also at increased risk for partial mole (relative risk, 4.03; 95% CI, 2.57-6.31), invasive mole (relative risk, 26.7; 95% CI, 7.81-93.14), and choriocarcinoma (relative risk, 6.29; 95% CI, 1.81-22.66) variants.


CONCLUSIONS
American Indians are at increased risk relative to the other predominant ethnic groups in New Mexico. Age-adjusted standardization provided a reproducible measurement that may be applicable across other registries.
Smith
Harriet O
HO
Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA. Hsmith@salud.unm.edu
Hilgers
Robert D
RD
Bedrick
Edward J
EJ
Qualls
Clifford R
CR
Wiggins
Charles L
CL
Rayburn
William F
WF
Waxman
Alan G
AG
Stephens
Nicole D
ND
Cole
Laurence W
LW
Swanson
Marian
M
Key
Charles R
CR
D000293:Adolescent; D000328:Adult; D002648:Child; D002822:Choriocarcinoma / Q000208:ethnology / Q000209:etiology; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000208:ethnology* / Q000209:etiology*; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D006828:Hydatidiform Mole / Q000208:ethnology / Q000209:etiology; D002820:Hydatidiform Mole, Invasive / Q000208:ethnology / Q000209:etiology; D007198:Indians, North American / Q000706:statistics & numerical data*; D009516:New Mexico / Q000453:epidemiology; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000208:ethnology / Q000209:etiology; D044465:White People / Q000706:statistics & numerical data*