Synthesis and antiinflammatory activity of novel indazolones.
In this study, a series of new N2 substituted 1,2-dihydro-3H-indazol-3-ones (3a-d) as well as their condensed pyrazolo, pyridazino derivatives such as pyridazino[1,2-a]indazole-6,9,11-triones (4a-h) and 3,9-dioxo-3H,9H-pyrazolo[1,2-a]indazole (7) were synthesized. The antiinflammatory activity of some synthesized compounds was determined by carrageenan-induced rat paw edema technique using diclofenac as reference drug. The pharmacological data showed that most of the tested compounds exhibited a significant long lasting antiinflammatory activity, which in the case of compound 3b was superior to that of diclofenac.
Abouzid
Khaled A M
KA
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt. abouzid@yahoo.com
el-Abhar
H S
HS
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D004008:Diclofenac / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D007191:Indazoles; D011720:Pyrazoles; D011724:Pyridazines; D011728:Pyridones; D004008:Diclofenac