Allele sharing in first-degree and unrelated pairs of individuals in the Ge F I AmpFlSTR Profiler Plus database.
Eleven Italian forensic laboratories participated in a population study based on the AB Profiler Plus loci with proficiency testing. The validated database, including 1340 individuals, is available on-line. Tests for Hardy-Weinberg equilibrium, gametic unbalance, and heterogeneity of gene frequency were generally not significant. Gene frequencies at each locus were consistent with those of two previously published Italian studies, but different from a third. Individuals of each subsample were paired, and the total number of alleles shared across the nine loci was determined in each pair. The analysis was replicated over the total sample. In addition, two samples of mother-child pairs (N=315) and full-sib pairs (N=91) were subjected to allele sharing analysis. The resulting distributions were sufficiently distinct from the sample of unrelated pairs as to be of practical usefulness.
Presciuttini
Silvano
S
Department of Biomedicine, University of Pisa, C/o Centro Retrovirus, S S Abetone e Brennero 2, 56127 Pisa, Italy. sprex@biomed.unipi.it
Ciampini
Francesca
F
Alù
Milena
M
Cerri
Nicoletta
N
Dobosz
Marina
M
Domenici
Ranieri
R
Peloso
Gabriella
G
Pelotti
Susi
S
Piccinini
Andrea
A
Ponzano
Elena
E
Ricci
Ugo
U
Tagliabracci
Adriano
A
Baley-Wilson
J E
JE
De Stefano
Francesco
F
Pascali
Vincenzo
V
D016172:DNA Fingerprinting / Q000379:methods; D030541:Databases, Genetic; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D007558:Italy; D009679:Nuclear Family; D016133:Polymerase Chain Reaction / Q000379:methods