Oxidative burst of Kupffer cells: target for liver injury treatment.
Liver injury, and frequent consequent fibrosis, is the focus of a number of research groups ranging from molecular biologists to clinicians. It encompasses many aspects and approaches. Among biochemical events the role of Kupffer cells, oxidative stress and pro-inflammatory mediators are eminent. In this review we focus on recent findings into use of natural substances for the modulation of oxidative burst as well as production of inflammatory mediators by Kupffer cells.
Vrba
Jirí
J
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
Modrianský
Martin
M
D016207:Cytokines / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007728:Kupffer Cells / Q000378:metabolism* / Q000502:physiology; D016897:Respiratory Burst
D016207:Cytokines; D018836:Inflammation Mediators