title: Medicinal chemistry of adenosine A1 receptor ligands.
abstract: In this review the latest developments in ligand design for the adenosine A(1) receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A(1) receptor are still scarce.
authors.affiliation: Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Soudijn
authors.forename: Ineke
authors.initials: I
authors.lastname: van Wijngaarden
authors.forename: Ad P
authors.initials: AP
authors.lastname: IJzerman
mesh_terms: D015195:Drug Design; D006801:Humans; D008024:Ligands; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1 / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1