title: [Study on the structure and activity of new phenolic acid compounds from Erigeron breviscapus].
abstract: OBJECTIVE
  To isolate and identify the active constituents of Erigeron brevisapus (Vant.) Hand.-Mazz.
  
  
  METHODS
  The chemical constituents were isolated by silica gel column chromatography and two new compounds were obtained. Their structures were elucidated by IR, MS, 1HNMR, 13CNMR, DEPT and 2DNMR. The injury of BCMEC (bovine cerebral microvascular endothelial cell) was determined by lactic dehydrogenase (LDH), the ability of the drugs anti-oxidation and scavenging oxidation of free radical was measured by colorimetric method.
  
  
  RESULTS
  Two new compounds have been identified as 1-O-methyl-3, 5-O-dicaffeoyl quinic acid methyl ester (III) and 5-O-caffeoyl quinic acid butyl ester (IV).
  
  
  CONCLUSIONS
  Compounds III and IV are new compounds. Compound III can protect BCMEC injury by LPC.
authors.affiliation: Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: W D
authors.initials: WD
authors.lastname: Zhang
authors.forename: T B
authors.initials: TB
authors.lastname: Ha
authors.forename: W S
authors.initials: WS
authors.lastname: Chen
authors.forename: D Y
authors.initials: DY
authors.lastname: Kong
authors.forename: H T
authors.initials: HT
authors.lastname: Li
authors.forename: Y H
authors.initials: YH
authors.lastname: Wang
authors.forename: I
authors.initials: I
authors.lastname: Fouraste
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D002469:Cell Separation; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008833:Microcirculation / Q000166:cytology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C481909:1-O-methyl-3,5-O-dicaffeoyl quinic acid methyl ester; C481910:5-O-caffeoyl quinic acid butyl ester; D000975:Antioxidants; D002109:Caffeic Acids; D020011:Protective Agents; D011801:Quinic Acid; D007770:L-Lactate Dehydrogenase