title: [A fiber optic chemical sensor system for on-line monitoring the drug dissolution of rifampicin].
abstract: OBJECTIVE
  To study a continuous, on-line and automatic monitoring method for dissolution of drugs.
  
  
  METHODS
  A new fiber optical chemical sensor prepared by sol-gel immobilization of molecular probe was reported. Based on multiple quenching of flurescence, an instrument and software system was designed to on-line monitor the drug dissolution of rifampicin.
  
  
  RESULTS
  The concentration of rifampicin was linear with ln(F0/F) when concentration was in the range of 10-170 micrograms/mL-1. The relative coefficient was 0.9993. The procession of dissolution can be on-line monitored. Parameters were obtained directly from the dissolution curve. There is no distinctly difference when compared with the method of the Pharmacopoeia of People's Republic of China (P > 0.05).
  
  
  CONCLUSIONS
  This procession analysis can reflect the real dissolution of drug and obtain the total information.
authors.affiliation: Department of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xin-xia
authors.initials: XX
authors.lastname: Li
authors.forename: Yu-wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000737:chemistry; D002214:Capsules; D001330:Electronic Data Processing; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
chemical_list: D000904:Antibiotics, Antitubercular; D002214:Capsules; D012293:Rifampin