title: Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates.
abstract: Platelet polymorphisms (Kozak, VNTR and HPA-2) within glycoprotein (GP)Ib alpha may be associated with an increased risk of arterial thrombosis. However, the functional role of these polymorphisms has not been clarified. Their influence on platelet plug formation under high shear rates was, therefore, examined in 233 healthy individuals. Collagen-adrenaline-induced closure time was shorter in carriers of the C/D versus C/C VNTR allele and in homozygotes with the (-5)T/T versus (-5)C/T Kozak genotype as determined by novel polymerase chain reaction methods. The HPA-2 genotype had no effects, and the density of GPIb alpha molecules was not influenced by GPIb alpha genotypes.
authors.affiliation: Department of Clinical Pharmacology-TARGET, Vienna University, Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Jilma-Stohlawetz
authors.forename: Monika
authors.initials: M
authors.lastname: Homoncik
authors.forename: Bernd
authors.initials: B
authors.lastname: Jilma
authors.forename: Maarten
authors.initials: M
authors.lastname: Knechtelsdorfer
authors.forename: Petra
authors.initials: P
authors.lastname: Unger
authors.forename: Christine
authors.initials: C
authors.lastname: Mannhalter
authors.forename: Sentot
authors.initials: S
authors.lastname: Santoso
authors.forename: Simon
authors.initials: S
authors.lastname: Panzer
mesh_terms: D000328:Adult; D000941:Antigens / Q000032:analysis; D005260:Female; D005838:Genotype; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000235:genetics*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014841:von Willebrand Factor / Q000276:immunology
chemical_list: D000941:Antigens; D019038:Platelet Glycoprotein GPIb-IX Complex; C029417:Von Willebrand antigen; D014841:von Willebrand Factor