O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans.
Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4'-sulfate. C. elegans also converted 5, 3', 4'-trihydroxy-7-methoxyflavanone into eriodictyol-4'-sulfate. Furthermore, incubation of 5, 4'-dihydroxy-7, 3'-dimethoxyflavanone with the same fungus gave homoeriodictyol (5, 7, 4'-trihydroxy-3'-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.
Ibrahim
Abdel-Rahim Sayed
AR
Pharmacognosy Departments, College of Pharmacy, Tanta University, Japan. arsib16@hotmail.com
Galal
Ahmed Mohamed
AM
Ahmed
Mohammed Shamim
MS
Mossa
Gabir Salem
GS
D020093:Cunninghamella / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D010090:Oxidoreductases, O-Demethylating / Q000737:chemistry / Q000378:metabolism; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism; D000094162:Phytoalexins
D005419:Flavonoids; D010090:Oxidoreductases, O-Demethylating; D013440:Sulfides; C099724:sakuranetin; D000094162:Phytoalexins