Plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes.
The antimutagenic effect of the bioactive compounds from fruits of Morus alba L. (MA), Punica granatum L. (PG), Diospyros kaki L. (DK), Cydonia oblonga Mill. (CO) and roots of Glycyrrhiza glabra (GG) were investigated. The antimutagenic effects of compounds separately as well as their action in complex mixtures were studied on mutations induced by genotoxicants (X-rays, N-methylnitrosourea, cyclophosphamide, NaF) and aging in bone marrow cell chromosomes from mice and rats. When tested separately and in a complex mixture, the plant products showed an ability to decrease the frequency of chromosome aberrations. The antimutagenic properties of the complex mixtures were considerably greater than those of the separate components. More antimutagenic activity of the mixture was revealed when mutagenesis was the result of X-rays and the natural aging processes.
Alekperov
Urkhan K
UK
Institute of Genetics, 155 Prospect Azadliq, 370106, Baku, Azerbaijan Republic.
D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects; D004195:Disease Models, Animal; D004781:Environmental Exposure / Q000009:adverse effects*; D029561:Lythraceae; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000494:pharmacology*; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity; D015262:Xenobiotics / Q000009:adverse effects*
D016587:Antimutagenic Agents; D010936:Plant Extracts; D015262:Xenobiotics