title: Pharmacological activities of crude acetone extract and purified constituents of Salvia moorcraftiana Wall.
abstract: The crude acetone extract of aerial parts of Salvia moorcraftiana Wall. was screened for various biological activities including Lemna bioassay, antifungal, antibacterial, leishmanicidal, insecticidal activities and brine shrimp cytotoxicity. It was found to possess strong phytotoxic activity against Lemna aequinoctials Welve. and moderate antifungal activity against animal and plant pathogens. The purified chemical constituents were tested for enzyme inhibition activity. Two constituents (compounds 3 and 8) were found to be effective inhibitors of alpha-glucosidase.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: T
authors.initials: T
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Zahid
authors.forename: M
authors.initials: M
authors.lastname: Asim
authors.lastname: Shahzad-ul-Hussan
authors.forename: Z
authors.initials: Z
authors.lastname: Iqbal
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: V Uddin
authors.initials: VU
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029064:Araceae / Q000187:drug effects; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001517:Coleoptera / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000517:prevention & control; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027544:Salvia
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007306:Insecticides; D010936:Plant Extracts