Drug-induced hepatitis with autoimmune features during minocycline therapy.
A 25-year-old woman with no history of liver disease developed liver dysfunction associated with severe jaundice and general malaise following a prolonged therapy with minocycline for acne vulgaris. Serum anti-nuclear antibody was detected and immunoglobulin G level was elevated. Symptoms resolved and liver function normalized following minocycline discontinuation and corticosteroid administration. Our diagnosis was drug-induced hepatitis with autoimmune features, as liver histology revealed acute hepatitis. Drug-induced hepatitis should be considered when liver dysfunction or systemic symptoms develops during long-term minocycline therapy.
Abe
Masanori
M
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295.
Furukawa
Shinya
S
Takayama
Shuzo
S
Michitaka
Kojiro
K
Minami
Hisaka
H
Yamamoto
Kazuhisa
K
Horiike
Norio
N
Onji
Morikazu
M
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008911:Minocycline / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D008911:Minocycline