title: Successful treatment of enterovirus-induced myocarditis with interferon-alpha.
abstract: No randomized, placebo-controlled studies have investigated interferon-alpha therapy in enterovirus-proven myocarditis. This report describes 2 patients with enterovirus-induced myocarditis (1 with associated Churg-Strauss syndrome) who at follow-up endomyocardial biopsy showed clinical and hemodynamic improvement and viral clearance (using polymerase chain reaction) after interferon-alpha therapy.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy. luciano.daliento@unipd.it
authors.forename: Luciano
authors.initials: L
authors.lastname: Daliento
authors.forename: Fiorella
authors.initials: F
authors.lastname: Calabrese
authors.forename: Francesco
authors.initials: F
authors.lastname: Tona
authors.forename: Alida L P
authors.initials: AL
authors.lastname: Caforio
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Tarsia
authors.forename: Annalisa
authors.initials: A
authors.lastname: Angelini
authors.forename: Gaetano
authors.initials: G
authors.lastname: Thiene
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000150:complications; D004769:Enterovirus Infections / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D009206:Myocardium / Q000473:pathology; D011994:Recombinant Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins