Allergen-independent maternal transmission of asthma susceptibility.
Maternal asthma is a risk factor for development of asthma in children, but mechanisms remain unclear. Offspring of asthmatic mother mice (sensitized and repeatedly exposed to OVA Ag) showed airway hyperresponsiveness and allergic pulmonary inflammation after an intentionally suboptimal OVA sensitization and exposure protocol that had little effect on normal offspring. Similar results were obtained when offspring of OVA-allergic mothers were exposed to an unrelated allergen, casein, indicating that the maternal effect is allergen independent and not transferred by OVA-specific Abs. Premating treatment with neutralizing anti-IL-4 Ab or reduction of maternal allergen exposure abrogated the maternal effect, showing a critical mechanistic role for IL-4 and suggesting an additional benefit of allergen avoidance.
Hamada
Kaoru
K
Nara Medical University, Nara, Japan.
Suzaki
Yasue
Y
Goldman
Alejandra
A
Ning
Yao Yu
YY
Goldsmith
Carroll
C
Palecanda
Aiyappa
A
Coull
Brent
B
Hubeau
Cedric
C
Kobzik
Lester
L
D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000918:Antibody Specificity; D001249:Asthma / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002364:Caseins / Q000008:administration & dosage / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007274:Injections, Intraperitoneal; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008807:Mice, Inbred BALB C; D009035:Mothers; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000473:pathology / Q000503:physiopathology
D000336:Aerosols; D000485:Allergens; D002364:Caseins; D000939:Epitopes; D007073:Immunoglobulin E; D010047:Ovalbumin