Anti-heparin-platelet factor 4 antibody is a risk factor for vascular access obstruction in patients undergoing hemodialysis.
Since heparin is an anticoagulant commonly used in hemodialysis and the patients on hemodialysis are repeatedly exposed to heparin, heparin may be the cause of the development of heparin-dependent antibodies and thrombotic complications in patients on hemodialysis. The purpose of this study was to determine the prevalence and the clinical significance of the antibodies against heparin-platelet factor 4 complexes as determined by enzyme immunoassay in patients on maintenance hemodialysis. The prevalence of anti-heparin-platelet factor 4 antibodies was higher in hemodialysis patients than in normal subjects (8.8 vs 0.0%, p<0.05). The number of past episodes of vascular access obstruction per year was significantly higher in the anti-heparin-platelet factor 4 antibody positive group than antibody negative group. Anti-heparin-platelet factor 4 antibody positive patients experienced more frequent vascular access obstructions than control subjects. In conclusion, anti-heparin-platelet factor 4 antibody might be a risk factor for vascular access obstructions in patients with end-stage renal disease on maintenance hemodialysis.
Lee
Eun-Young
EY
Department of Internal Medicine and Clinical Research Institute, Soonchunhyang University Chonan Hospital, 23-30 Bongmyungdong, Chonan 330-721, Korea.
Hwang
Kyu-Yoon
KY
Yang
Jong-Oh
JO
Hong
Sae-Yong
SY
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D002408:Catheters, Indwelling; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006493:Heparin / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000276:immunology*; D012008:Recurrence; D006435:Renal Dialysis; D012307:Risk Factors; D019851:Thrombophilia / Q000276:immunology*; D013927:Thrombosis / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control
D001323:Autoantibodies; D010978:Platelet Factor 4; D006493:Heparin