title: Immune-mediated fever in the dog. Occurrence of antinuclear antibodies, rheumatoid factor, tumor necrosis factor and interleukin-6 in serum.
abstract: Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nuclear antigens (ENA), 1 out of 20 was positive to antibodies against deoxynucleoproteins (DNP), 2 out of 13 were RF positive and none out of 20 patients had antibodies against native DNA in the serum. TNF-alpha was not detected in any serum of 15 dogs with immune-mediated fever, while 10 out of 13 presented with elevated IL-6. The results varied between patients, but the IL-6 level was high in most of them. This indicate a role for IL-6 in the pathogenesis of immune-mediated fever in most cases.
authors.affiliation: Department of Immunology and Transfusion Medicine, University Hospital of Trondheim, Trondheim, Norway.
authors.forename: J Ovrebø
authors.initials: JO
authors.lastname: Bohnhorst
authors.forename: I
authors.initials: I
authors.lastname: Hanssen
authors.forename: Torolf
authors.initials: T
authors.lastname: Moen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000276:immunology; D004285:Dogs; D005260:Female; D005335:Fever of Unknown Origin / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D012217:Rheumatoid Factor / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D012217:Rheumatoid Factor; D011239:Prednisolone