Iminosugars and relatives as antiviral and potential anti-infective agents.
Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.
Greimel
P
P
Glycogroup, Institut für Organische Chemie der Technischen Universität Graz, Stremayrgasse 16, Austria.
Spreitz
J
J
Stütz
A E
AE
Wrodnigg
T M
TM
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009005:Monosaccharides