Chlorine kinetic isotope effects on enzymatic dehalogenations.
Enzymatic dehalogenation reactions are important for the bioremediation of the environment because of the increasing anthropogenic pollution with halogen-containing organic compounds. Chlorine kinetic isotope effects have been measured for four hydrolytic dehalogenases. On the basis of these isotope effects, several details of the mechanisms of the enzymatic dehalogenation reactions have been revealed.
Paneth
Piotr
P
Institute of Applied Radiation Chemistry, Department of Chemistry, Technical University of Lodz, Zeromskiego 116, 90-924 Lodz, Poland.
D002713:Chlorine; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D006867:Hydrolases / Q000378:metabolism*; D007554:Isotopes; D007700:Kinetics; D008956:Models, Chemical
D006843:Hydrocarbons, Chlorinated; D007554:Isotopes; D002713:Chlorine; D006867:Hydrolases; C084333:4-chlorobenzoyl coenzyme A dehalogenase; C042472:fluoroacetate-specific dehalogenase; C034507:2-haloacid dehalogenase; C046137:haloalkane dehalogenase