title: [Tissue insulin resistance and endothelial function of large vessels in patients with arterial hypertension].
abstract: OBJECTIVE
  To examine insulin resistance and hyperinsulinemia in obese patients with moderate arterial hypertension (AH) without diabetes mellitus, glucose intolerance, and ischemic heart disease; to evaluate the endothelial vasomotor function of large vessels.
  
  
  METHODS
  41 males (mean age 49.3 +/- 5.4 years) with AH were examined by anthropometry, measurements of the levels of glucose, immunoreactive insulin, C-peptide, and biochemical blood tests. Endothelial vasomotor function was assessed ultrasonically.
  
  
  RESULTS
  Insulin resistance preceding abnormal glucose tolerance was found in 52.4% of the patients with AH and obesity. In these patients lipid metabolic disturbances were more pronounced than in those without hyperinsulinemia. There was endothelial vasomotor dysfunction with preserved capacity of arteriolar and capillary walls for vasodilatation irrespective of the presence or absence of insulin resistance.
  
  
  CONCLUSIONS
  Insulin resistance and endothelial dysfunction are most common in hypertensive patients with obesity.
authors.forename: F M
authors.initials: FM
authors.lastname: Baĭramgulov
authors.forename: A D
authors.initials: AD
authors.lastname: Bulgakova
authors.forename: M E
authors.initials: ME
authors.lastname: Kurelenkova
authors.forename: L Kh
authors.initials: LKh
authors.lastname: Kurbangaleeva
authors.forename: Z S
authors.initials: ZS
authors.lastname: Zakirova
authors.forename: F L
authors.initials: FL
authors.lastname: Timirkhanova
authors.forename: N R
authors.initials: NR
authors.lastname: Bikmetova
mesh_terms: D000328:Adult; D003971:Diastole; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects; D013599:Systole