Acquisition of siderophores in gram-negative bacteria.
The outer membrane of Gram-negative bacteria constitutes a permeability barrier that protects the cell from exterior hazards, but also complicates the uptake of nutrients. In the case of iron, the challenge is even greater, because of the scarcity of this indispensable element in the cell's surroundings. To solve this dilemma, bacteria have evolved sophisticated mechanisms whereby the concerted actions of receptor, transporter and energy-transducing proteins ensure that there is a sufficient supply of iron-containing compounds, such as siderophores.
Faraldo-Gómez
José D
JD
Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. josed@biop.ox.ac.uk
Sansom
Mark S P
MS
D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006418:Heme; D006801:Humans; D007501:Iron / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017262:Siderophores / Q000378:metabolism*; D015398:Signal Transduction; D014774:Virulence
D001425:Bacterial Outer Membrane Proteins; D026901:Membrane Transport Proteins; D011956:Receptors, Cell Surface; D017262:Siderophores; D006418:Heme; D007501:Iron