title: MHC typing in variant Creutzfeldt-Jakob disease.
abstract: Identification of factors that cause susceptibility to, and clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future management of the disease. We established MHC genotypes of 76 individuals with vCJD and 131 controls, and analysed MHC phenotypes in relation to age of onset of vCJD and its duration from presentation to death. There were no significant differences between vCJD and control populations in frequencies of any MHC types, nor were there associations between MHC type and age of onset or duration of vCJD disease. Our results do not support the idea of an association between MHC types and either susceptibility to, or expression of, vCJD.
authors.affiliation: Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF, London, UK. m.pepys@rfc.ucl.ac.uk
authors.forename: Mark B
authors.initials: MB
authors.lastname: Pepys
authors.forename: Alison
authors.initials: A
authors.lastname: Bybee
authors.forename: David R
authors.initials: DR
authors.lastname: Booth
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Bishop
authors.forename: Robert G
authors.initials: RG
authors.lastname: Will
authors.forename: Ann-Margaret
authors.initials: AM
authors.lastname: Little
authors.forename: Bedrich
authors.initials: B
authors.lastname: Prokupek
authors.forename: J Alejandro
authors.initials: JA
authors.lastname: Madrigal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D006113:United Kingdom
chemical_list: D006680:HLA Antigens