[The effects of starfish sterol on platelet aggregation].
Through the internal and external experiments of platelet aggregation on rats and rabbits, we study the effects of starfish sterol (No. A1998) on the formation of experimental thrombus in vitro and the effects of platelet aggregation induced by arachidonic acid (AA), ADP, CaCl2. Starfish sterol A 1998 can inhibit the formation of experimental thrombus in vitro of rats on the rates of 10.0%, 20.1%, 25.9% (P < 0.01), p.o. starfish sterol 4.5, 13.5, 40.5 mg/kg. A 1998 can inhibit platelet aggregation induced by AA, ADP, CaCl2 in the same time. It can be concluded that starfish sterol has inhibitory effects on platelet aggregation.
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Section of Drugs and Pharmacology, Department of Pharmacy, Zhongshan University, Guangzhou, 510275.
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D000244:Adenosine Diphosphate; D000818:Animals; D016718:Arachidonic Acid; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013215:Starfish / Q000737:chemistry*; D013261:Sterols / Q000008:administration & dosage / Q000494:pharmacology*; D013927:Thrombosis / Q000139:chemically induced / Q000473:pathology
D008419:Materia Medica; D010975:Platelet Aggregation Inhibitors; D013261:Sterols; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate