Comparison of antiallergic drugs in an experimental model of ocular anaphylaxis.
OBJECTIVE
To compare the efficacy of antiallergic drugs in an experimental ocular anaphylaxis model.


METHODS
Fifty-two rats were divided into 8 groups. Dithiothreitol and ovalbumin (OVA) were applied to both eyes of previously OVA-inoculated rats in groups 1-5 and 7. In groups 1-5, antiallergic efficacy of the drugs (lodoxamide, sodium cromoglycate, levacobastine, cimetidine, and diclofenac sodium) instilled on the right eyes were compared with the buffer instilled on the left eyes, measuring the amount of extravasated Evans blue (EB) dye by spectrophotometric analysis. Group 6 served as a control of EB dye extravasations in nonimmunized eyes. Histopathologic examinations for anaphylaxis and controls were done in groups 7 and 8.


RESULTS
Only levacobastine and lodoxamide decreased vascular permeability at a significant ratio (46%, p < 0.01 and 31%, p < 0.05, respectively).


CONCLUSIONS
Levacobastine and lodoxamide but none of the three other drugs mentioned above were found to be effective in decreasing vascular permeability.
Bayer
Atilla
A
Gülhane Military Medical Academy and Medical School(GATA), Ankara, Turkey. atillabayer@hotmail.com
Uludağ
H Avni
HA
Sobaci
Güngör
G
Mutlu
Fatih Mehmet
FM
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D003228:Conjunctiva / Q000098:blood supply / Q000187:drug effects; D003233:Conjunctivitis, Allergic / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004229:Dithiothreitol; D008297:Male; D009883:Ophthalmic Solutions; D010047:Ovalbumin; D051381:Rats; D017208:Rats, Wistar
D018926:Anti-Allergic Agents; D009883:Ophthalmic Solutions; D010047:Ovalbumin; D004229:Dithiothreitol