title: New biflavanones and bioactive compounds from Stellera chamaejasme L.
abstract: OBJECTIVE
  To study the chemical constituents of the root of Stellera chamaejasme L.
  
  
  METHODS
  Various column chromatographies on silica gel and RP-18 were employed for isolation and purification. Structures of compounds were elucidated by spectral analysis.
  
  
  RESULTS
  Eight lignans and three biflavonoids possessing a C-3/C-3" linkage were isolated. They are ruixianglangdusu A (1) and B (2), 4',4'",5,5",7,7"-hexahydroxy-3,3"-biflavone (3), (+)-kusunokinin (4), lirioresinol-B (5), magnolenin C (6), (-)-pinoresinol monomethyl ether (7), (-)-pinoresinol (8), (+)-matairesinol (9), isohinokinin (10) and (-)-eudesmin (11).
  
  
  CONCLUSIONS
  Compounds 1 and 2 are new biflavanones, 1 is enantiomeric to known chamaejasmenin C, 4, 6, 8, 9, 10 and 11 were isolated from this plant for the first time, and 7 was isolated from natural resources for the first time. In vitro bioassays showed that 3 and 8 exhibited antibacterial activity, and 1, 2, 9 and 11 exhibited immunomodulatory activity.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Xu
authors.forename: G W
authors.initials: GW
authors.lastname: Qin
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.forename: R S
authors.initials: RS
authors.lastname: Xu
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D044950:Flavanones; C481167:ruixianglangdusu A; C481168:ruixianglangdusu B