Autoimmune neutropenia associated with multiple sclerosis.
A 53-year-old Japanese man with multiple sclerosis developed autoimmune neutropenia. The neutrophil count was consistently less than 0.2 x 10(9)/l, irrespective of the disease activity of multiple sclerosis or the administration of immunosuppressive agents or granulocyte colony-stimulating factor. After high-dose gamma-globulin therapy was started, temporary increases in the neutrophil count were observed. Despite a wide spectrum of clinical manifestations in multiple sclerosis, autoimmune neutropenia has never been reported previously.
Kozuka
Teruhiko
T
Department of Internal Medicine II, Okayama University Medical School, Okayama.
Kojima
Kensuke
K
Kaneda
Kinuyo
K
Takenaka
Katsuto
K
Manabe
Yasuhiro
Y
Hirata
Yasushi
Y
Okuma
Shigenori
S
Toki
Hironobu
H
Tanimoto
Mitsune
M
D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000628:therapy; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007937:Leukapheresis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000628:therapy; D009503:Neutropenia / Q000097:blood / Q000150:complications* / Q000628:therapy; D009504:Neutrophils; D005719:gamma-Globulins / Q000008:administration & dosage
D007166:Immunosuppressive Agents; D005719:gamma-Globulins; D016572:Cyclosporine