title: Color Doppler imaging of choroidal circulation in patients with asymmetric age-related macular degeneration.
abstract: We aimed at evaluating the possible role of choroidal perfusion abnormalities in the development of choroidal neovascularisation (CNV) in patients with age-related macular degeneration (AMD). Twenty-six patients who had non-exudative AMD in the first eye and CNV secondary to AMD in the fellow eye were enrolled. Blood flow velocities, vessel pulsatilities and resistivities were measured from ophthalmic artery, nasal and temporal posterior ciliary arteries using colour Doppler imaging. Systolic and diastolic velocities were lower in eyes with CNV for all vessels, except for the systolic velocity of the nasal posterior ciliary artery (p >0.05). Pulsatility and resistivity indices were higher in eyes with CNV for all vessels. This difference was statistically significant for the resistivity index of the nasal and temporal posterior ciliary arteries (p = 0.032 and p = 0.021, respectively) and the pulsatility index of the nasal posterior ciliary artery (p = 0.035). We have shown that in patients with AMD choroidal blood flow is more impaired in the eyes with CNV than in the fellow eyes.
authors.affiliation: Department of Ophthalmology, Ege University School of Medicine, Izmir, Turkey. uretmen@med.ege.edu.tr
authors.forename: Onder
authors.initials: O
authors.lastname: Uretmen
authors.forename: Cezmi
authors.initials: C
authors.lastname: Akkin
authors.forename: Tansu
authors.initials: T
authors.lastname: Erakgün
authors.forename: Refik
authors.initials: R
authors.lastname: Killi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology; D002829:Choroid / Q000098:blood supply* / Q000000981:diagnostic imaging; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D019842:Ciliary Arteries / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D018615:Ultrasonography, Doppler, Color / Q000379:methods