Role of cytokines in the development and maintenance of memory T cells during respiratory viral infection.
Much progress has been made in understanding the relationship between cytokines, T cell development, and the maintenance of memory T cells by examining the immune response to respiratory viral infections. Most of these studies have examined the T cell response to viruses that cause acute infection of limited duration, and have focused on the interplay between cytokines and individual responses by T cell subsets. This reductionism approach has been useful to piece together the puzzle of the host-immune response to respiratory virus infection, and has added to the holistic view of the networks involved in homeostatic control of T cell development and maintenance. This review addresses aspects of T cell biology that constitute the response to respiratory viral infections.
Tripp
Ralph A
RA
Centers for Disease Control and Prevention, National Center for Infectious Diseases, Respiratory and Enteric Viruses Branch, 1600 Clifton Rd, Mailstop G-09, Atlanta, GA 30333, USA. rgt3@cdc.gov
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology
D016207:Cytokines