[Approach to the crystalline characteristics of ceftezole sodium].
OBJECTIVE
To study the crystalline characteristics of ceftezole sodium.


METHODS
Ceftezole sodium crystals were obtained from different solvents. X-ray diffraction, DSC, TGA, etc were used to analyze the crytals.


RESULTS
Ceftezole sodium crystal was easily obtained in isopropanol-water mixture. It consists of ceftizole sodium monohydrate, which consists of type I and type II two different crystal forms. Powder X-ray diffraction patterns showed differences between type I and the type II crystal forms. Peaks at 8 degrees and 18 degrees in diffractograms of the type I, but at 9 degrees and 18.6 degrees in the type II could be observed. Water molecules in different crystal forms had different combining condition. They lost during 35-117 degrees C in the type I form, but lost during 110-160 degrees C in the type II form.


CONCLUSIONS
Structure of ceftizole sodium monohydrate crystal obtained in different circumstance could be some vary, which influence upon the thermal stability of the compound. The type I crystal form is more stable than the type II.
Hu
Chang-qin
CQ
National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China. hucq@nicpbp.org.cn
Cheng
Shuang-hong
SH
Lu
Lu
L
D002437:Cefazolin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000145:classification; D003460:Crystallization; D018360:Crystallography, X-Ray; D004355:Drug Stability; D008968:Molecular Conformation; D015394:Molecular Structure
C012811:ceftezole; D002437:Cefazolin