Genetics of IL-13 and functional relevance of IL-13 variants.
Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator of allergic inflammation. Numerous single nucleotide polymorphisms have been recently identified in the IL-13 gene and have been found to be associated with allergic and/or asthmatic phenotypes in different populations throughout the world. Furthermore, functional genomics studies are highlighting mechanistic pathways that may link genetic variation in IL-13 and disease. IL-13 is therefore an ideal model to study the impact of genetic variation on the regulation of gene expression and function in complex diseases.
Vercelli
Donata
D
Arizona Respiratory Center, Tucson, USA. donata@resp-sci.arizona.edu
D000818:Animals; D001249:Asthma / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics; D018793:Interleukin-13 / Q000235:genetics*; D051379:Mice; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D016207:Cytokines; D018793:Interleukin-13; D007073:Immunoglobulin E