[Immune functional changes in patients of acute Henoch-Schonlein purpura and regulatory effect of integrated Traditional Chinese and Western medicine on it].
OBJECTIVE
To observe the changes of immune function in children with acute Henoch-Schonlein purpura (AHSP) and the effects of integrated traditional Chinese and western medicine (TCM-WM) on it.


METHODS
Immunological criteria in TCM-WM group (n = 35) treated by Yinfu Decoction (YFD) combined with transfer factor and 35 patients in the control group (n = 35) treated by conventional treatment were observed and compared before and after treatment. Also the criteria were compared with those of 40 healthy subjects.


RESULTS
Before treatment, the levels of IgA, IgM, CD4, CD4/CD8 ratio, rosette forming rate of RBC-C3b receptor in patients were higher than those in the healthy subjects, but the levels of CD8 was obviously lower, the difference was significant (P < 0.01). The above-mentioned criteria were all improved in the two treated groups after treatment, and the improvement was more significant in the TCM-WM group than that in the control group (P < 0.05). Besides, the cure-markedly effective rate in the former was better than that in the latter significantly (P < 0.01).


CONCLUSIONS
There exist multiple immune functional disturbance in AHSP patients. Combined treatment of YFD and transfer factor has obvious immune regulatory effect and is an effective therapy with few side-effects and low recurrence rate.
Jia
W C
WC
First Affiliated Hospital of Zhangjiakou Medical College, Hebei 075000.
Zhang
Y C
YC
Wei
A P
AP
D000293:Adolescent; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008517:Phytotherapy; D014165:Transfer Factor / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D014165:Transfer Factor