Study of gamma-interferon in schistosomiasis mansoni, autoimmune diseases and schistosomal arthropathy.
IFN-gamma, a Th1 cytokine was quantitatively estimated using EASIA in the sera of patients with different stages of schistosomiasis mansoni autoimmune diseases and schistosomal arthropathy. Level of IFN-gamma was significantly elevated in all the test groups compared to the control group. The highest level of IFN-gamma observed was in RA and SLE, with insignificant statistical difference (P > 0.05) between them. Cases with early S. mansoni infection showed significant higher level (P < 0.05) of IFN-gamma compared to hepatosplenic schistosomiasis with and without ascites. A significant statistical difference (P < 0.05) concerning IFN-gamma level was observed when comparing RA and SLE to different stages of S. mansoni infection and schistosomal arthropathy. This might lead to a conclusion that IFN-gamma estimation in sera of patients having joint complaint could be a good marker for differentiation between autoimmune collagen induced arthritis and schistosomiasis induced arthropathy.
Abdel-Aaty
H E
HE
Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Selim
M M
MM
Abdel-Rehim
H A
HA
D001170:Arthritis, Infectious; D001172:Arthritis, Rheumatoid; D001327:Autoimmune Diseases; D015415:Biomarkers; D003095:Collagen Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000097:blood*; D008180:Lupus Erythematosus, Systemic; D012555:Schistosomiasis mansoni; D012680:Sensitivity and Specificity
D015415:Biomarkers; D007371:Interferon-gamma