title: [Clinical observation on effect of kesuning granule in treating acute onset of chronic bronchitis].
abstract: OBJECTIVE
  To prove the effect of Kesuning Granule (KSNG) in treating chronic bronchitis in exacerbation (Phlegm-Heat syndrome) and objectively evaluate its safety.
  
  
  METHODS
  The double-blinded, double-dummy and randomized controlled method was adopted to observe 120 patients, who were divided into the treated group (n = 60, treated with KSNG 8 g, three times a day) and the control group (n = 60, treated with Jinbei Tankeqing Granule (JBTKQ) 7 g, three times a day). The therapeutic course for both groups was 6 days.
  
  
  RESULTS
  In the treated group, the markedly effective rate was 58.33% and effective rate was 93.33%, while in the control group, they were 51.67% and 91.67% respectively, no significant difference was found between the two groups. For therapeutic effects on TCM syndromes, the markedly effective rate and effective rate in the treated group was 68.33% and 93.33% respectively and in the control group, 66.67% and 90.00% respectively, also showed insignificant difference. The effect initiative time was earlier in the treated group than that in the control group significantly (P < 0.05). No adverse effect was found in the observation.
  
  
  CONCLUSIONS
  KSNG shows a definite clinical effect with no obvious toxic-adverse effects.
authors.affiliation: West China Hospital, Sichuan University, Chengdu 610041.
authors.forename: Bing
authors.initials: B
authors.lastname: Mao
authors.forename: Rui-ming
authors.initials: RM
authors.lastname: Zhang
authors.forename: Ting-qian
authors.initials: TQ
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D029481:Bronchitis, Chronic / Q000188:drug therapy*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal