Concomitant association of thyroid sarcoidosis and Graves' disease.
OBJECTIVE
Graves' disease (GD) with sarcoid involvement of the thyroid gland has rarely been reported.


METHODS
We report a case of GD with thyroid sarcoidosis in a 28-year-old woman. Thyroid function was assessed by triiodothyronine (T(3)), thyroxine (T(4)), thyroid-stimulating hormone (TSH) and TSH receptor antibodies (TSH-R Ab). Thyroid scintigraphy, ultrasound and fine-needle aspiration biopsy were performed. The patient underwent surgery.


RESULTS
The patient had a nodular goiter. Serum T(3), T(4) and TSH-R Ab levels were elevated with suppressed TSH level. Scintigraphy showed diffuse activity as seen in GD, and ultrasound revealed that parenchyma was heterogenous. Sarcoidosis was discovered on routine chest X-ray. Although no sarcoid involvement was found on specimen, the thyroid gland showed non-caseating granulomas on histology.


CONCLUSIONS
Since sarcoid involvement of the thyroid gland can cause hypofunction, we report the uncommon infiltration of sarcoidosis with hyperthyroidism.
Yarman
S
S
Division of Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Turkey. esyarman@hotmail.com
Kahraman
H
H
Tanakol
R
R
Kapran
Y
Y
D000328:Adult; D000906:Antibodies / Q000032:analysis; D001707:Biopsy, Needle; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007159:Immunologic Tests; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000150:complications* / Q000000981:diagnostic imaging; D013959:Thyroid Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D013963:Thyroid Hormones / Q000276:immunology; D014463:Ultrasonography
D000906:Antibodies; D013963:Thyroid Hormones