Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats.
Adult male hooded Lister rats were either fed a diet containing 150 microg/g soya phytoestrogens or a soya-free diet for 18 days. This concentration of phytoestrogens should have been sufficient to occupy the oestrogen-beta, but not the oestrogen-alpha, receptors. Using in situ hybridisation, significant reductions were found in brain-derived neurotrophic factor (BDNF) mRNA expression in the CA3 and CA4 region of the hippocampus and in the cerebral cortex in the rats fed the diet containing phytoestrogens, compared with those on the soya-free diet. No changes in glutamic acid decarboxylase-67 or glial fibrillary acidic protein mRNA were found. This suggests a role for oestrogen-beta receptors in regulating BDNF mRNA expression.
File
Sandra E
SE
Psychopharmacology Research Unit and Biochemical Neuropharmacology Group, Centre for Neuroscience Research, King's College London, Hodgkin Building, Guy's Campus, SE1 1UL, London, UK.
Hartley
David E
DE
Alom
Nazmul
N
Rattray
Marcus
M
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D017403:In Situ Hybridization; D007529:Isoflavones; D008297:Male; D048789:Phytoestrogens; D028321:Plant Preparations; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D013025:Glycine max
D019208:Brain-Derived Neurotrophic Factor; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D012333:RNA, Messenger