[Effect of huadai xingshen decoction on cerebral somatostatin, arginine vasopressin and somatostatin mRNA expression in vascular dementia rat model].
OBJECTIVE
To study the mechanism of Huadai Xingshen Decoction (HDXSD) in treating vascular dementia (VD).


METHODS
Rat model of VD was established by repeated ischemia/reperfusion and treated with HDXSD. Hydergine was taken for positive control. The content of somatostatin (SS), arginine vasopressin (AVP) and SS mRNA expression model rat's cortex and hippocampus were observed.


RESULTS
The SS and AVP contents of cortex and hippocampus in model rats were decreased significantly, and the SSmRNA expression in cortex of frontal lobe reduced, too. HDXSD showed an up-regulation on the above-mentioned parameters, and the effect on SS cortex and SS mRNA expression was higher than that of hydergine.


CONCLUSIONS
HDXSD improves intellectual impairment of VD rats by increasing the synthetic ability of SSmRNA and content of AVP, which in turn improve the neurotrophic effect and promote the restoring function of injured neuron.
Zhang
L
L
Beijing University of Traditional Chinese Medicine, Beijing 100029.
Wang
H T
HT
D000818:Animals; D001127:Arginine Vasopressin / Q000096:biosynthesis* / Q000235:genetics; D002540:Cerebral Cortex / Q000378:metabolism; D015140:Dementia, Vascular / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000096:biosynthesis* / Q000235:genetics
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D001127:Arginine Vasopressin; D013004:Somatostatin