Viral proteinases--possible targets of antiviral drugs.
Viral infections represent various types of human, veterinary and plant diseases with a significant economic, ethic and demographic impact. Over the years a significant effort has been made to develop various means of prevention and therapy of viral diseases. Proteinases play an important role in the process of virus replication as well as in the pathophysiology of many viral diseases. The aim of this review is to assess the prospects of the application of proteinase inhibitors in antiviral therapy and to characterize viral proteinases of various classes. Six Human immunodeficiency virus (HIV) proteinase inhibitors have been approved for therapeutic use and can serve as examples of prospective application ofproteinase inhibitors to antiviral therapy.
Maliar
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T
Research Institute for Drugs, Horná 36, 900 01, Modra, Slovak Republic. maliar@vulm.sk
Baláz
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S
Tandlich
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R
Sturdík
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E
D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009842:Oligopeptides / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D012697:Serine Endopeptidases / Q000378:metabolism; D014764:Viral Proteins / Q000037:antagonists & inhibitors*; D014780:Viruses / Q000201:enzymology
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011480:Protease Inhibitors; D014764:Viral Proteins; D012697:Serine Endopeptidases; D003546:Cysteine Endopeptidases; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases