Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages.
The authors measured the presence and extent of asymptomatic microbleeds on gradient-recalled-echo MRI in 21 aspirin users who developed intracerebral hemorrhage and 21 aspirin users without history of intracerebral hemorrhage. Microbleeds were more frequent (19 vs 7, p < 0.001) and more extensive (mean number of microbleeds 13.3 vs 0.4, p < 0.001) in the intracerebral hemorrhage group than in the control group. Asymptomatic microbleeds may be a risk factor for aspirin-associated intracerebral hemorrhage.
Wong
K S
KS
Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin. ks-wong@cuhk.edu.hk
Chan
Y L
YL
Liu
J Y
JY
Gao
S
S
Lam
W W M
WW
D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D006485:Hemosiderin / Q000032:analysis; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D011237:Predictive Value of Tests; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D016861:Cyclooxygenase Inhibitors; D006485:Hemosiderin; D001241:Aspirin