Alkylresorcinol derivatives and sesquiterpene lactones from Cichorium spinosum.
One new alkylresorcinol derivative, cichoriol B, and a mixture of three other ones, cichoriols A, C, and D, were isolated from the dichloromethane extract of Cichorium spinosum, a plant that is used traditionally in the Cretan diet. The methanol extract afforded one new sesquiterpene lactone, (4R)-3,4-dihydrolactucopicrin. The structures of the new compounds were determined by spectroscopic methods, mainly by the concerted application of 1D and 2D NMR techniques (HMQC, HMBC, NOESY).
Melliou
Eleni
E
Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, Greece.
Magiatis
Prokopios
P
Skaltsounis
Alexios-Leandros
AL
D019659:Asteraceae / Q000737:chemistry*; D006115:Greece; D007783:Lactones / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008752:Methylene Chloride; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012118:Resorcinols / Q000032:analysis* / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis*
C472681:3,4-dihydrolactucopicrin; D007783:Lactones; D010936:Plant Extracts; D012118:Resorcinols; D012717:Sesquiterpenes; C472680:cichoriol A; D008752:Methylene Chloride