title: Photosynthetic electron transport inhibition by 2-substituted 4-alkyl-6-benzylamino-1,3,5-triazines with thylakoids from wild-type and atrazine-resistant Chenopodium album.
abstract: The effect of 2-benzylamino-1,3,5-triazines on photosynthetic electron transport (PET) was measured with thylakoids isolated from atrazine-resistant, wild-type Chenopodium album, and spinach to find novel 1,3,5-triazine herbicides bearing a strong PET inhibition. The PET inhibition assay with Chenopodium (wild-type and resistant), yielded a resistance ratio (R/W = I50 (resistant)/I50 (wild-type)) of 324 for atrazine while for benzylamino-1,3,5-triazine derivatives of diamino-1,3,5-triazines a R/W of 11 to 160 was found. The compounds having a benzylamino group at one of the amino groups in the diamino-1,3,5-triazines have a resistant ratio down to one half to 1/30 of the atrazine value. The average resistance ratio of 21 benzylamino derivatives of monoamino-1,3,5-triazines was found to be about 4.0. The inhibition of 21 benzylamino-1,3,5-triazines assayed with atrazine-resistant Chenopodium thylakoids, indicated by pI50 (R)-values, correlated well with the PET inhibition pI50 (W) of wild-type thylakoids from Chenopodium.
authors.affiliation: Graduate School of Agricultural Science, Tamagawa University, Machida-shi, Tokyo 194-8610, Japan.
authors.forename: Ruiko
authors.initials: R
authors.lastname: Okano
authors.forename: Aiko
authors.initials: A
authors.lastname: Ohki
authors.forename: Shinpei
authors.initials: S
authors.lastname: Ohki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kohno
authors.forename: Jack J S
authors.initials: JJ
authors.lastname: van Rensen
authors.forename: Peter
authors.initials: P
authors.lastname: Böger
authors.forename: Ko
authors.initials: K
authors.lastname: Wakabayashi
mesh_terms: D001280:Atrazine / Q000494:pharmacology*; D027463:Chenopodium album / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D004351:Drug Resistance; D004579:Electron Transport / Q000187:drug effects; D006540:Herbicides / Q000494:pharmacology; D010788:Photosynthesis / Q000187:drug effects*; D020524:Thylakoids / Q000187:drug effects*; D014227:Triazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006540:Herbicides; D014227:Triazines; D001280:Atrazine