title: Weight gain and glucose and lipid metabolism disturbances during antipsychotic medication: a review.
abstract: Antipsychotic medication is the mainstay of treatment for functional psychotic illnesses. However, for some patients weight gain and the disturbances in blood-lipid levels and glucose balance associated with their use are significant disadvantages, and pose health risks that may affect prognosis. A substantial body of evidence suggests that weight gain is at least partly related to the blocking effects of antipsychotic medication on serotonin- and histamine-mediated neurotransmission. The disadvantages associated with weight gain can be reduced by an appropriate choice of antipsychotic and avoidance of polypharmacy, by regular monitoring of the patient's weight, and, if necessary, by the patient's participation in a dieting programme.
authors.affiliation: Department of Psychiatry, University of Oulu, Oulu, Finland. hannu.koponen@reimari.net
authors.forename: Hannu
authors.initials: H
authors.lastname: Koponen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Saari
authors.forename: Markku
authors.initials: M
authors.lastname: Savolainen
authors.forename: Matti
authors.initials: M
authors.lastname: Isohanni
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000378:metabolism; D012307:Risk Factors; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D008055:Lipids