Pulmonary lymphomatoid granulomatosis evolving to large cell lymphoma in the skin.
Lymphomatoid granulomatosis is an angiodestructive, angioinvasive lymphoproliferative disorder. It involves most frequently lungs, central nervous system and skin. Recent studies indicate that lymphomatoid granulomatosis is an Epstein-Barr virus associated B cell disorder with a background of reactive T lymphocytes. In a 49 year old woman presenting with fever, malaise and pulmonary masses the diagnosis of lymphomatoid granulomatosis was established histologically by open lung biopsy. Following the initial diagnosis the patient was found to have gastric and skin involvement. The skin lesion was diagnosed as diffuse large B-cell lymphoma.
Culhaci
Nil
N
Department of Pathology, Adnan Menderes University, Faculty of Medicine, Aydin, 09100, Turkey. nculhaci@hotmail.com
Levi
Edi
E
Sen
Serdar
S
Kacar
Furuzan
F
Meteoglu
Ibrahim
I
D001402:B-Lymphocytes / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology*; D008230:Lymphomatoid Granulomatosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D014057:Tomography, X-Ray Computed