title: Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder.
abstract: Lack of normal structural asymmetry of the anterior cingulate gyrus (ACG) in patients with schizophrenia has been reported in our previous study. However, to our knowledge, no morphological studies of the brain have examined changes in ACG volume in patients with schizotypal features. We investigated the volume of the gray matter and the white matter of the ACG by three-dimensional magnetic resonance imaging (MRI) in 24 patients who met the ICD-10 criteria for schizotypal disorder (12 males, 12 females) in comparison with 48 age- and gender-matched healthy control subjects (24 males, 24 females) and 40 patients with schizophrenia (20 males, 20 females). As we reported previously, right ACG gray matter volume was significantly reduced in the female patients with schizophrenia compared with the female controls. On the other hand, the gray and white matter volume of the ACG in the patients with schizotypal disorder did not differ significantly from the values in the healthy controls or the patients with schizophrenia. However, the female patients with schizotypal disorder showed a lack of right-greater-than-left asymmetry of the ACG gray and white matter found in the female controls. These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities.
authors.affiliation: Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. tsutomu@ms.toyama-mpu.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hagino
authors.forename: Ikiko
authors.initials: I
authors.lastname: Yamashita
authors.forename: Shi-Yu
authors.initials: SY
authors.lastname: Zhou
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nohara
authors.forename: Kazue
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004292:Dominance, Cerebral; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000473:pathology* / Q000503:physiopathology; D012737:Sex Factors