Immunoglobulin-M estimation and C-reactive protein detection in neonatal septicemia.
Immunoglobulin-M estimation, and C-Reactive Protein test and blood culture were performed on 57 neonates, clinically suspected to have septicemia. IgM level of > or = 20 mg/dl was found in 58.62% cases and CRP test was positive in 68.98% of culture proven sepsis. Blood culture was positive in 29 cases, with the predominant organism being Klebsiella. Of the 2 tests, CRP had a higher sensitivity (68.97%) while IgM estimation had a higher specificity (82.14%). When the 2 tests were considered together the sensitivity and specificity further increased. Death rate among neonates with IgM levels < 20 mg/dl was 5 times higher than those with elevated IgM levels.
Krishna
B V
BV
Department of Microbiology, Karnatak Institute of Medical Sciences Hubli-580 002, Karnataka.
Nadgir
S D
SD
Tallur
S S
SS
D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology / Q000401:mortality; D001769:Blood / Q000382:microbiology; D002097:C-Reactive Protein / Q000378:metabolism*; D003470:Culture Media; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007231:Infant, Newborn; D012680:Sensitivity and Specificity
D003470:Culture Media; D007075:Immunoglobulin M; D002097:C-Reactive Protein