[Effect of para-aminobenzoic acid on the growth of Actinomyces viscosus].
OBJECTIVE
To examine the effects of para-aminobenzoic acid (PABA) on the growth of Actinomyces viscosus.


METHODS
Different concentrations of PABA (10(-10)-10(-3) g/L) were each transferred to modified Carlsson medium. Actinomyces viscosus ATCC19246 grew in them. And the cultures were incubated at 37 degrees C anaerobically in the atmosphere of 80%N2, 10%H2, 10%CO2 for 48 h. Actinomyces viscosus OD values (lambda = 540 nm) were obtained with UV-1601. Colony forming unit (CFU) was established by growth of Actinomyces viscosus in culture when different concentrations of PABA (10(-10)-10(-3) g/L) were present.


RESULTS
Different concentrations of PABA (10(-10)-10(-4) g/L) had different stimulating effects on the growth of Actinomyces viscosus (P < 0.05). But this kind of stimulating effect declined when PABA concentration was 10(-5) g/L, and as PABA (10(-3) g/L) was present, this kind of effect was missing.


CONCLUSIONS
The phenomena indicated that PABA has stimulating effect on the growth of Actinomyces viscosus, particularly when PABA is at the concentration of 10(-6) g/L.
Guo
Bin
B
West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Zhou
Xuedong
X
Xiao
Xiaorong
X
Li
Lei
L
Zhu
Zhu
Z
D016924:Actinomyces viscosus / Q000187:drug effects* / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D009570:Nitriles / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects
D009570:Nitriles; C045271:4-aminobenzonitrile