title: A case of tuberculous sinusitis without concomitant pulmonary disease.
abstract: This case report highlights the difficulty of diagnosing tuberculous sinusitis in the absence of pulmonary foci. Although extrapulmonary localisations of tuberculosis are rare in immunocompetent patients, it is important to consider this diagnosis, since therapeutic delay usually results in an unfavourable outcome. Acid-fast bacilli are sometimes difficult to detect in pathological specimens. Consequently, the diagnosis is usually based on the following criteria: (i) the absence of clinical response to usual antibiotics, (ii) the presence of caseous granulomatous inflammatory lesion on histopathology, and (iii) identification of Mycobacterium tuberculosis by the polymerase chain reaction assay confirmed by bacteriological culture. The diagnosis of tuberculosis is finally confirmed by the efficacy of antituberculous treatment. The differential diagnosis is Wegener's disease.
authors.affiliation: Infectiology and Internal Medicine Unit, Hôpital Nord, Place Victor Pauchet, 80054 Amiens, France.
authors.forename: S
authors.initials: S
authors.lastname: Beltran
authors.forename: Y
authors.initials: Y
authors.lastname: Douadi
authors.forename: F X
authors.initials: FX
authors.lastname: Lescure
authors.forename: M
authors.initials: M
authors.lastname: Hanau
authors.forename: G
authors.initials: G
authors.lastname: Laurans
authors.forename: J P
authors.initials: JP
authors.lastname: Ducroix
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents