title: Keratoacanthoma developing in sites of previous trauma: a report of two cases and review of the literature.
abstract: Keratoacanthoma is a common benign squamous neoplasm that only rarely progresses to metastatic carcinoma. The cause of keratoacanthoma is unclear; however, suspected causes include ultraviolet light, genetic factors, immunosuppression, chemical carcinogens, viruses, and trauma. Keratoacanthomas have been reported only rarely to arise in sites of previous trauma. We report 2 cases of keratoacanthomas arising shortly after episodes of cutaneous trauma and provide a review of the literature of similar cases previously reported. It is likely that an interaction exists between a variety of factors in the development of keratoacanthomas; however, it appears that a predilection exists for these lesions to arise in trauma sites.
authors.affiliation: Section of Dermatology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
authors.forename: Sean F
authors.initials: SF
authors.lastname: Pattee
authors.forename: Nancy G
authors.initials: NG
authors.lastname: Silvis
mesh_terms: D000368:Aged; D005542:Forearm; D006801:Humans; D007636:Keratoacanthoma / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014947:Wounds and Injuries / Q000150:complications*