[Comparison of the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis].
OBJECTIVE
To observe the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis in adults.


METHODS
Patients with acute or chronic sinusitis were randomly assigned to receive either levofloxacin (200 mg orally once daily, 200/100 mg twice daily) or cefuroxime (250 mg orally twice daily) for 10 to 14 days. Pre- or post-treatment, the clinical and laboratory examination were done and in the end of treatment, the efficacy and safety were assessment.


RESULTS
The success rates after the end of treatment were 97.4% for the 76 patients who received levofloxacin and 92.8% for the 14 patients who received cefuroxime. The resolution rates of bacteria were 91.6% and 80.0%, respectively. The safety of these two groups were more high.


CONCLUSIONS
Levofloxacin is effective for the treatment of sinusitis in adults and pay attention to the course of treatment for raising the efficacy of treatment.
Li
X P
XP
Department of Otolaryngology, Third Hospital, Beijing University, Beijing 100083.
Qin
Z M
ZM
Zheng
R H
RH
Tan
Q L
QL
Zhou
Y Y
YY
Zhu
L
L
Yin
A F
AF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002444:Cefuroxime / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012852:Sinusitis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin; D002444:Cefuroxime