Hemoglobin switching: new insights.
During the past year, many interesting advances have been made regarding molecular mechanisms controlling beta-like globin gene switching. Throughout the beta locus, -acting elements exist that are dynamically bound by trans-acting proteins, including transcription factors, coactivators, repressors, and chromatin modifiers. Characterization of transcription factors, their interaction with one another, and an ever-increasing role for chromatin structure in gene expression have enhanced understanding of the mechanism of globin gene switching. The studies reviewed here contribute new insights on the interplay between -acting elements, transcription factors, and chromatin modifiers that underlie globin gene switching during development.
Peterson
Kenneth R
KR
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. KPETERSON@kumc.edu
D000818:Animals; D005786:Gene Expression Regulation; D005812:Genes, Switch; D005914:Globins / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics*; D006801:Humans; D011401:Promoter Regions, Genetic; D014157:Transcription Factors
D006454:Hemoglobins; D014157:Transcription Factors; D005914:Globins