title: Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional magnetic resonance imaging.
abstract: In vivo brain imaging and postmortem investigations have demonstrated ventricular enlargement in the brains of schizophrenic patients. However, the extent of changes in the volume of discrete ventricle subdivisions has not been clearly established. We conducted high-resolution three-dimensional magnetic resonance imaging in 40 schizophrenic patients (20 males and 20 females) and 40 healthy volunteers (20 males and 20 females). The lateral ventricle in each hemisphere was divided into the anterior horn, body, posterior horn and temporal horn. The volumes of the hemispheres, four subdivisions of the lateral ventricles and the third ventricle were measured. Compared to the control subjects, the bilateral hemisphere volumes were significantly lower in the patients than in the control subjects. In the lateral ventricular subdivisions of the male patients, the most substantial volume increase was in the left temporal horn, and volume increases were also observed in the bilateral anterior horns and the right body. The male patients also had a significantly increased volume of the third ventricle. The female patients showed similar patterns with less statistical significance. Thus, the schizophrenia patients showed ventricular enlargement, particularly in the left temporal horn, being more severely affected in the male than in the female.
authors.affiliation: Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yotsutsuji
authors.forename: Osamu
authors.initials: O
authors.lastname: Saitoh
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hagino
authors.forename: Kouichi
authors.initials: K
authors.lastname: Mori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Mie
authors.initials: M
authors.lastname: Matsui
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000328:Adult; D002552:Cerebral Ventricles / Q000473:pathology*; D004867:Equipment Design; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D012559:Schizophrenia / Q000473:pathology*