VBP-1 is necessary for morphogenesis in Caenorhabditis elegans.
VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early stage embryos. Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis.
Ichimiya
Harumi
H
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Hino
Okio
O
Kohara
Yuji
Y
Ishii
Naoaki
N
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D003598:Cytoskeletal Proteins; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D017238:Genes, Helminth / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D009024:Morphogenesis; D034622:RNA Interference; D015347:RNA Probes; D012330:RNA, Double-Stranded / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D018832:Molecular Chaperones; D015347:RNA Probes; D012330:RNA, Double-Stranded; D025521:Tumor Suppressor Proteins; C108825:VBP1 protein, human; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D008025:Ligases; C497446:VHL protein, human