[Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria].
In this paper, we concentrated in examining, in vitro, the antiseptic activity of the baicalein and baicalin upon the seventeen pathogenic skin fungal and sixteen skin bacterial strains, these two flavonic compounds were known principally as the biosubstances of a traditional Chinese medicinal plant: Scutellaria baicalensis. In agar media, the baicalein possessed potent specific activity against the pathogenic yeasts with MICs of 70-100 micrograms/ml; But in the same condition, no inhibitory effect was observed upon dermatophytes and filamentous imperfect fungi for baicalein, and upon all used strains for baicalin. According to the antibacterial test of baicalein, a high efficacy was achieved against certain causative specie of axillary and foot's odour such as Micrococcus sedentarius, Staphylococcus epidermidis, S. hominis and C. xerosis with a MICs inferior to 250 micrograms/ml. The good inhibitory activity of baicalein could be linked to the group hydroxyl (-OH) in position seven of the molecule.
Yang
D
D
School of Life Sciences, University of Zhougshan, Guangzhou 510275.
Hu
H
H
Huang
S
S
Chaumont
J P
JP
Millet
J
J
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D003454:Cryptococcus / Q000187:drug effects* / Q000302:isolation & purification; D003881:Dermatomycoses / Q000382:microbiology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008837:Micrococcus / Q000187:drug effects / Q000302:isolation & purification; D008864:Microsporum / Q000187:drug effects / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D031364:Scutellaria baicalensis / Q000737:chemistry; D017192:Skin Diseases, Bacterial / Q000382:microbiology
D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein