title: [A case of Tinea capitis caused by Trichophyton tonsurans].
abstract: A 10-year-old Peruvian girl, living in Japan since 1996, visited our hospital in August 2000 complaining of alopecia which had been present on her scalp for one year. The bald areas appeared as multiple small, scattered, angular patches with indistinct margins. Follicular pustules, erythemic nodules and lymphadenopathy were also seen. In the culture of the affected hair, a tan surface with wiry undulations grew on Sabouraud's media. The colony reverse had reddish-brown central pigmentation. Slide cultured fungi produced great numbers of round and short club-shaped microconidia, hyphae and intercalary chlamydospores. These fungi showed the following characteristics: positive urease test, no pigment production on cornmeal agar and positive thiamine dependency. The restriction fragment length polymorphism pattern and the nucleotide sequences of ribosomal-DNA internal transcribed spacer region of the causative fungus was compatible with Trichophyton tonsurans. Daily administration of 125 mg of terbinafine resulted in a satisfactory response and the lesion healed almost completely.
authors.affiliation: Department of Dermatology, Ensyu General Hospital, Shizuoka, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Urano
authors.forename: Shigeko
authors.initials: S
authors.lastname: Shirai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Sugaya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takigawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000284:Administration, Oral; D001483:Base Sequence; D002648:Child; D004271:DNA, Fungal / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D005260:Female; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage; D012150:Polymorphism, Restriction Fragment Length; D000077291:Terbinafine; D014006:Tinea Capitis / Q000188:drug therapy / Q000382:microbiology*; D016896:Treatment Outcome; D014249:Trichophyton / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D009281:Naphthalenes; D000077291:Terbinafine