[The protective effect of bicyclol on ischemia-reperfusion induced kidney injury in rats].
OBJECTIVE
To investigate the protective effect of bicyclol on kidney injury induced by ischemia-reperfusion in rats.


METHODS
Bicyclol was orally administered to rats at doses of 50 and 200 mg.kg-1 before ischemia-reperfusion injury to evaluate the influence of bicyclol on the formation of MDA and BUN in serum, the content of GSH and the activity of GST in kidney, as well as kidney mitochondria membrane fluidity in ischaemia-reperfusion rats.


RESULTS
Bicyclol given orally at doses of 50 and 200 mg.kg-1 was shown to significantly decrease the increment of MDA and BUN in serum and protect the GSH depletion in kidney. Bicyclol was also shown to induce kidney GST and ameliorate the decrease of mitochondria membrane fluidity. The protective effects of bicyclol on kidney injury induced by ischemia-reperfusion are dose-dependent.


CONCLUSIONS
The protective action of bicyclol on kidney injury induced by ischemia-reperfusion may be attributed to its induction of kidney GSH and the GST, stabilization on mitochondria membrane and the inhibition on lipid peroxidation.
Zhao
Dong-mei
DM
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Sun
Tao
T
Li
Yan
Y
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007511:Ischemia / Q000150:complications / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008560:Membrane Fluidity / Q000187:drug effects; D008928:Mitochondria / Q000648:ultrastructure; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
D001713:Biphenyl Compounds; D020011:Protective Agents; D008315:Malondialdehyde; C477843:bicyclol; D005982:Glutathione Transferase; D005978:Glutathione