Synthesis and structural study of substituted thioxothiazolidinones and thioxoimidazolidinones.
A new set of derivative thioxothiazolidinones and thioxoimidazolidinones 3,5-dissubstituted has been synthesized with satisfactory yield from the condensation Knoevenagel type between benzaldéhydes and 4-thioxothiazolidin-2-one, 2-thioxothiazolidin-4-one and 1-méthyl-2-thioxoimidazolidin-4-one compounds following by N-alkylation with aryl or acyl halides. The physico-chemical properties of the 5-benzylidene-3-[2-(4-chlorophenyl)-2-oxoethyl]-2 (or 4)-thioxothiazolidin-4 (or 2)-ones and 5-benzylidene-1-methyl-2-thioxoimidazolidin-4-ones synthesized have been described.
Andrade
A M C
AM
Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, João Pessoa, Brasil.
Lima
W T
WT
Rocha
M P A
MP
Lima
M C A
MC
Galdino
S L
SL
Barbosa Filho
J M
JM
Góes
A J S
AJ
Pitta
I R
IR
D000478:Alkylation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry*
D007093:Imidazoles; D007202:Indicators and Reagents; D013844:Thiazoles; D013871:Thiones