[Experimental study on effect of xinkang oral liquid on coxsackie B3 viral myocarditis in mice].
OBJECTIVE
To study the therapeutic effect of Xinkang Oral Liquid (XKOL) in treating acute Coxsackie B3 viral myocarditis in mice.


METHODS
Viral myocarditis model was established by intraperitoneal inoculation with Coxsackie B3 virus. Mice were randomly divided into 4 groups randomly, the model group, the positive control group (treated with Ribavilin), the XKOL group and the normal control group. Body weight of mice was weighed at the 5th, 10th and 20th day. Weight, macro- and histopathologic changes of heart were observed by microscope and measured by morphometric quantification, and the data were treated statistically.


RESULTS
In the XKOL group, the body weight of mice increased, the degree of myocardial necrosis mild and small in size, which has been repaired more completely, the antiviral effect was found in XKOL group.


CONCLUSIONS
XKOL has definite therapeutic effect on viral myocarditis, its effect is better than Ribavilin in protecting myocardium and anti-virus.
Zhao
H
H
Department of Pathology, Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037.
Wan
S J
SJ
Xu
X L
XL
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D029822:Enterovirus B, Human; D004769:Enterovirus Infections / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D009205:Myocarditis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation
D004365:Drugs, Chinese Herbal