[Clinical significance of the detection of the sL-selectin level in patients with acute leukemia].
OBJECTIVE
To study the relationship between the episode and state of acute leukemia and the level of soluble L-selectin (sL-selectin) in the plasma and cerebrospinal fluid.


METHODS
With a sandwich enzyme-linked immunosorbent assay (ELISA), the levels of sL-selectin in the plasma of 40 patients with acute leukemia and in the cerebrospinal fluid of 28 patients with acute lymphoblastic leukemia were measured, and compared with 20 controls.


RESULTS
The levels of sL-selectin were significantly higher in the patients with untreated and therapy-resistant acute leukemia or leukemia relapse than those in the complete remission patients and the controls (P < 0.001). The levels of SL-selectin were related to the clinical course of acute leukemia.


CONCLUSIONS
Monitoring the sL-selectin level may be useful for evaluating leukemia activity, in particular for the detection of leukemia relapse and meningeal infiltration.
Chang
Jian-hua
JH
Department of Clinical Haematology, Xiangya Hospital, Central South University, Changsha 410008, China.
Qi
Zhen-hua
ZH
Xu
Min
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000097:blood* / Q000134:cerebrospinal fluid; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000134:cerebrospinal fluid
D014408:Biomarkers, Tumor; D019041:L-Selectin