[Treatment of lumbar intervertebral disk prolapse by estradural injection of mailuoning and its influence on dynorphin A in cerebrospinal fluid].
OBJECTIVE
To explore the modulating effects of extradural injection of Mailuoning on analgesic function.


METHODS
Twenty patients of lumbar intervertebral disk prolapse were treated by extradural injection of Mailuoning, the spontaneous release of dynorphin A (Dyn-A) in cerebrospinal fluid (CSF) before and after treatment were measured and compared with that of the 20 cases in the control group to determine the therapeutic effect of Mailuoning.


RESULTS
After treatment, the concentration of Dyn-A in CSF in the treated group increased remarkably, but displayed no significant difference to normal healthy group (P > 0.05), while that in the control group there was significant difference between them (P < 0.01).


CONCLUSIONS
Mailuoning has the modulatory effect on analgesia function and lumbar intervertral disk prolapse was treated by means of its Dyn-A elevating action.
Cheng
W
W
Xiyuan Hospital, China Academy of TCM, Beijing 100091.
Dong
F H
FH
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004399:Dynorphins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D007405:Intervertebral Disc Displacement / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D000700:Analgesics; D004365:Drugs, Chinese Herbal; D004399:Dynorphins