Peripheral sensory neuropathy associated with short-term oral acitretin therapy.
A 57-year-old female patient with widespread chronic plaque psoriasis and a 32-year-old male patient with severe oral lichen planus are reported, who developed sensory symptoms in the extremities 3 and 4 months after the onset of oral acitretin therapy, respectively. Both patients showed clinical and electrophysiological evidence of a sensory peripheral neuropathy, which completely resolved 2 and 2.5 years after discontinuation of oral acitretin administration, respectively.
Tsambaos
D
D
Department of Dermatology, University of Patras, Greece. tsambaos@med.upatras.gr
Sakkis
T
T
Chroni
E
E
Koniavitou
K
K
Monastirli
A
A
Pasmatzi
E
E
Paschalis
C
C
D017255:Acitretin / Q000008:administration & dosage / Q000009:adverse effects*; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D017676:Lichen Planus, Oral / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy
D007641:Keratolytic Agents; D017255:Acitretin