title: Toward the synthesis of peloruside a: fragment synthesis and coupling studies.
abstract: [reaction: see text] The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C(12)-C(19), C(7)-C(11), and C(1)-C(6) segments of peloruside A, is reported, along with boron-mediated aldol coupling studies directed toward the assembly of the complete carbon skeleton of this microtubule-stabilizing macrolide.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, United Kingdom. ip100@cus.cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: M Emilia
authors.initials: ME
authors.lastname: Di Francesco
authors.forename: Toralf
authors.initials: T
authors.lastname: Kühn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism; D050257:Tubulin Modulators
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D050257:Tubulin Modulators; C414085:peloruside A