[In vitro drug release behavior of carrier made of porous glass ceramics].
OBJECTIVE
To conduct the in vitro test on drug release of rifampin encapsulated in a carrier made of porous phosphate glass ceramics and to analyze main factors which affect the drug release rate.


METHODS
A certain quantitative of rifampin was sealed in a hollow cylindrical capsule which consisted of chopped calcium phosphate crystal fiber obtained from glass crystallization. The rifampin concentration was measured in the simulated physiological solution in which the capsule soaked.


RESULTS
Rifampin could be released in a constant rate from the porous glass ceramic carrier in a long time. The release rate was dependent on the size of crystal fiber and the wall thickness of the capsule.


CONCLUSIONS
This kind of calcium phosphate glass ceramics can be a candidate of the carrier materials used as long term drug therapy after osteotomy surgery.
Wang
De-ping
DP
College of Materials Science & Engineering, Tongji University, Shanghai, P. R. China 200092.
Huang
Wen-hai
WH
Zhou
Nai
N
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D002516:Ceramics; D004337:Drug Carriers; D005898:Glass; D066298:In Vitro Techniques; D008422:Materials Testing; D012293:Rifampin / Q000008:administration & dosage* / Q000493:pharmacokinetics
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D004337:Drug Carriers; D012293:Rifampin