Unique bioconcentration characteristics of new aryl fluoroalkyl ethers in common carp (Cyprinus carpio).
The bioconcentration factors (BCFs) of seven new aryl fluoroalkyl ethers--four bis-4-tetrafluoroethoxyphenyl-type (bis-type) compounds and three mono-4-tetrafluoroethoxyphenyl-type (mono-type) compounds--were obtained by bioconcentration tests using common carp. The BCFs of 4 of the 7 ethers were higher than 5000, indicating their high bioconcentration potential. The bioconcentration characteristics of the bis-type compounds were different from those of the mono-type compounds and non-fluoro diphenylmethanes with a similar skeleton structure to the bis-type compounds, in taking longer to reach a plateau and having a slower elimination rate and in their distribution patterns in the fish body. The BCF of 1 bis-type compound was much higher than the value predicted by an accepted correlation equation between BCF and P(ow). In addition, the logP(ow) of the bis-type compounds calculated by commercially available computer software was remarkably different from that measured.
Yakata
Naoaki
N
Chemicals Evaluation and Research Institute, Kurume Laboratory, 19-14 Chuo-machi, Kurume, Fukuoka 830-0023, Japan. yakata-noaki@ceri.jp
Sudo
Yoshihisa
Y
Yakabe
Yoshikuni
Y
Tadokoro
Hiroshi
H
Fukui
Hiroyuki
H
Sanechika
Kenichi
K
Ikeda
Masanori
M
D000818:Animals; D002347:Carps / Q000378:metabolism*; D004987:Ethers / Q000378:metabolism*; D017611:Fluorine Compounds / Q000378:metabolism*; D012984:Software
D004987:Ethers; D017611:Fluorine Compounds