[The study on the anti-oxidation effect of root of Mallotus apelta in the rat model of liver fibrosis].
OBJECTIVE
To investigate the effect of root of Mallotus apelta in treatment of liver fibrosis and the effect of anti-oxidation in the rat model of liver fibrosis.


METHODS
A rat model of liver fibrosis was induced with 40% CCl4 in peanut oil. A series of items were detected, which include ALT, AST, MDA, NO and hydroxyproline in the blood or liver tissues.


RESULTS
The level of ALT, MDA, NO in serum were significantly decreased, the level of hydroxyproline was declined too, while the formation of liver fibrosis was successfully ameliorated.


CONCLUSIONS
The root of Mallotus apelta could retain the progression of liver fibrosis, having a capacity of anti-oxidation. And the latter might be the reason of the former function.
Zhao
Jinjun
J
First Military Medical University, Gunagzhou 510515.
Lü
Zhiping
Z
Wang
Xiaodong
X
Zhang
Xufu
X
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000209:etiology / Q000378:metabolism*; D008297:Male; D036461:Mallotus Plant / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004365:Drugs, Chinese Herbal