Impact of posterior GPI pallidotomy on leg tremor in Parkinson's disease.
Although stereotactic thalamotomy is the mainstay in the surgical treatment of tremor in patients with Parkinson's disease (PD), this surgery is not favored and is even a matter of potential concern in the treatment of leg tremor since it carries a significant risk of injury to the internal capsule. In this study we have carried out a quantitative assessment of leg tremor alleviation in 12 patients with PD after MRI-/microelectrode-guided stereotactic ablation of the posterior part of the globus pallidus internus (GPi). The results showed that posterior GPi pallidotomy combined with drug therapy is a satisfactorily effective therapeutic strategy to treat parkinsonian leg tremor.
Goto
Satoshi
S
Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan. sgoto@kaiju.medic.kumamoto-u.ac.jp
Nishikawa
Shigeyuki
S
Mita
Shuji
S
Ushio
Yukitaka
Y
D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007866:Leg / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D038361:Neuronavigation / Q000379:methods; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D014202:Tremor / Q000503:physiopathology / Q000601:surgery*