Facile construction and divergent transformation of polycyclic isoxazoles: direct access to polyketide architectures.
[reaction: see text] Base-promoted cyclocondensation of C-chloro oximes with cyclic 1,3-diketones affords functionalized isoxazoles in good yield and under convenient reaction conditions. This process enables the synthesis of highly substituted products with notable functional group tolerance. The products obtained are directly converted to a variety of polyketide-derived polycyclic structures including xanthenes, anthracenes, and benzophenones.
Bode
Jeffrey W
JW
Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Hachisu
Yoshifumi
Y
Matsuura
Tomoo
T
Suzuki
Keisuke
K