Organogenesis: making pancreas from liver.
Making endocrine pancreas cells at will is one of the major goals of cellular based therapies for diabetes. The experimentally induced conversion of hepatocytes into pancreatic cells, using a modified version of the transcription factor Pdx-1, may provide an alternative to stem cell approaches.
McLin
Valerie A
VA
Division of Gastroenterology, Hepatology and Nutrition,Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
Zorn
Aaron M
AM
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D018398:Homeodomain Proteins; D008099:Liver / Q000254:growth & development*; D009024:Morphogenesis; D010179:Pancreas / Q000254:growth & development*; D015534:Trans-Activators / Q000378:metabolism*; D019076:Transgenes; D014982:Xenopus laevis / Q000502:physiology
D018398:Homeodomain Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein