A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus.
A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
Abbaskhan
Ahmed
A
Choudhary
M Iqbal
MI
Tsuda
Yoshisuke
Y
Parvez
Masood
M
Atta-ur-Rahman
Shaheen
Farzana
F
Parween
Zeba
Z
Tareen
Rasool Baksh
RB
Zaidi
Mudassir Asrar
MA
D018360:Crystallography, X-Ray; D037602:Isodon / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D014315:Triterpenes; C473345:rugosinin