[Studies on chemical constituents of Uvaria macrophylia].
OBJECTIVE
To study the chemical constituents from Uvaria macrophylla Roxb. (Annonaceae).


METHODS
Various chromatography techniques were used to separate and purify the constituents. Their structures were elucidated by UV, IR, MS, 1HNMR, 13CNMR, 1H-1H COSY, HMQC and HMBC spectral analysis.


RESULTS
Seven compounds have been isolated from the CHCl3 extract of the roots of the U. macrophylla. They were identified as macrophyllin (1), onysilin (2), taraxerol (3), 3,5-dimethoxy benzyl benzoic acid ester (4), benzoic acid (5), beta-sitosterol (6) and daucosterol (7).


CONCLUSIONS
Compound 1 is a new compound. Compounds 2-7 were obtained from this plant for the first time.
Zhang
Hai-ling
HL
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Wang
Si
S
Chen
Ruo-yun
RY
Yu
De-quan
DQ
D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification; D031046:Uvaria / Q000737:chemistry*
D005419:Flavonoids; D012855:Sitosterols; C479286:macrophyllol; C025473:gamma-sitosterol; D009828:Oleanolic Acid; C005802:taraxerol