title: Effects of natural polysaccharide addition on drug release from calcium-induced alginate gel beads.
abstract: Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca.
authors.affiliation: Faculty of Pharmaceutical Science, Hokuriku University, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Murata
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tsumoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kofuji
authors.forename: Susumu
authors.initials: S
authors.lastname: Kawashima
mesh_terms: D000464:Alginates / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D002118:Calcium / Q000737:chemistry / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D005782:Gels; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D011134:Polysaccharides / Q000138:chemical synthesis / Q000493:pharmacokinetics*
chemical_list: D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D011134:Polysaccharides; D020723:Glucuronic Acid; D002118:Calcium