title: The analysis of pedigree GZ (Guangzhou). 1 with primary open angle glaucoma.
abstract: OBJECTIVE
  To analyze the hereditary modality of primary open-angle glaucoma in China.
  
  
  METHODS
  The genetic form of Pedigree GZ. 1 was analyzed using Mandalian hereditary rules.
  
  
  RESULTS
  Pedigree GZ. 1 had following characteristics: 1) The pedigree had four generations, and there existed POAG patients in each generation; 2) Each patient had a parent with POAG. If the parents didn't suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1/2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients.
  
  
  CONCLUSIONS
  1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhuo
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D005136:Eye Proteins / Q000235:genetics; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009154:Mutation; D010375:Pedigree
chemical_list: D005136:Eye Proteins; D006023:Glycoproteins