title: Early events in the pathogenesis of a murine transfer colitis.
abstract: Inflammatory bowel disease (IBD) is a chronic, disabling disease. A dysregulated immune response seems to play a pivotal role in the pathogenesis of this disorder. Here we will review current concepts of the adoptive transfer model of IBD with particular emphasis on early events in disease development. In the adoptive transfer model, the reconstitution of immunoincompetent mice with CD4+ T cells from congenic donor animals leads to severe colitis. We will address the question as to which CD4+ T cell subsets might be involved in the induction, suppression, or regulation of disease, and review data concerning the specificity of their T cell receptor and its putative MHC restriction elements. We will also discuss whether and at what anatomical sites donor T cells could be primed in the recipient.
authors.affiliation: Department of Pathology, University of Ulm, Ulm, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Leithäuser
authors.forename: Tamara
authors.initials: T
authors.lastname: Krajina
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Trobonjaca
authors.forename: Jörg
authors.initials: J
authors.lastname: Reimann
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D017690:Cell Transplantation; D003093:Colitis, Ulcerative / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains