[Effects of Angelica polysaccharide on blood coagulation and platelet aggregation].
OBJECTIVE
To investigate the effects of angelica polysaccharide (AP) on blood coagulation and platelet aggregation.


METHODS
Infrared turbidimetric method was used to estimate platelet aggregation, active partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT); bleeding time (BT) was measured by cutting the mouse's tail and coagulate time (CT) was measured by dropping the blood on carry sheet glass.


RESULTS
AP prominently enhanced the platelet aggregation at 5 min, while showed less effects on the maximum platelet aggregation. It also markedly prolonged CT but shortened BT. AP significantly prolonged TT and APTT in dosage of 3 mg/kg and 10 mg/kg, while showed no obvious effect on PT.


CONCLUSIONS
These results suggest that AP has potent anticoagulant and haemostasis effects. The haemostasis effect is related to promoting platelet aggregation.
Yang
Tiehong
T
Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033.
Jia
Min
M
Mei
Qibing
Q
Shang
Peng
P
D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides