Chemoselective radical cleavage of Cbz-protected nitrogen compounds.
[reaction: see text] Tributylstannyl radicals promote the deprotection of N-Cbz derivatives of amides and nitrogen-containing heteroaromatic rings. These radical conditions do not affect N-Cbz derivatives of basic amines.
Bennasar
M-Lluïsa
ML
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona 08028, Spain. bennasar@farmacia.far.ub.es
Roca
Tomàs
T
Padullés
Ariadna
A