title: First total synthesis of leucamide A.
abstract: The first total synthesis of marine bioactive cyclic heptapeptide Leucamide A has been accomplished, including a simple method for construction of the 4,2-bisheterocycle tandem pair substructure that employs a DAST-mediated cyclization of beta-hydroxy amide and final HBTU-promoted ring closing.
authors.affiliation: National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Wang
authors.forename: Fajun
authors.initials: F
authors.lastname: Nan
mesh_terms: D000818:Animals; D002384:Catalysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; C470214:leucamide A