[Comparison of the effects of xianyu tablet and its component on electrophoretic mobility of serum LDL and expression of ET-1 mRNA and iNOS mRNA of vessel wall in atherosclerotic rabbits].
Xiaoyu tablet, a compound preparation of Chinese herbal medicines, consists of Radix Salviae Miltiorrhizae(SM) and Fructus Crataegi(FC) extracts. To determine whether the proved recipe was reasonable, the effects of Xiaoyu tablet and its component on electrophoretic mobility of serum LDL and expression of ET-1 mRNA and iNOS mRNA of vessel wall in atherosclerotic rabbits were observed. The results indicated that inhibition of expression iNOS mRNA in vessel wall by Xiaoyu tablet was the same as its single extract of SM or FC, but Xiaoyu talbet was superior to SM or FC extract in reduction of electrophoretic mobility of serum LDL and inhibition of ET-1 mRNA expression in vessel wall. These results suggested that there was obvious synergism on prevention and treatment of atherosclerosis when both of the Chinese herbal medicines were simultaneously used.
Xie
M
M
Suzhou Institute of Chinese Materia Medica, Suzhou 215007.
Lu
Q
Q
Zhu
L
L
Gu
Z
Z
D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism* / Q000517:prevention & control; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000096:biosynthesis* / Q000235:genetics; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008297:Male; D019001:Nitric Oxide Synthase / Q000096:biosynthesis* / Q000235:genetics; D008517:Phytotherapy; D010936:Plant Extracts; D012333:RNA, Messenger / Q000096:biosynthesis; D011817:Rabbits; D027561:Salvia miltiorrhiza; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D012333:RNA, Messenger; D013607:Tablets; D019001:Nitric Oxide Synthase