[Studies on Euphorbia fischeriana diterpenoide lactones inhibitory effect on human tumor cells in vitro].
In this paper, two diterpenoide lactones 16-hydroxypseudojolkinolide B and jolkinolide B were isolated from Euphorbia fischeriana Steud. They showed inhibitory effect on human tumor cells both the K562 cell and CNE2 cell and significant dose-effect relationship. The IC50 values of 16-hydroxypseudojolkinolide B on the two human tumor cells were near to that of ADM's.
Liu
W
W
Sun Yat-sen University of Medical Sciences, Guangzhou 510089.
He
F
F
Ruan
Z
Z
Gu
X
X
Wu
X
X
Qin
G
G
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
C483327:16-hydroxypseudojolkinolide B; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C057914:jolkinolide B