IgA pemphigus occurring in a 1-month-old infant.
An 11-month-old girl had recurrent pruritic vesiculopustular lesions involving the trunk, extremities, and scalp since the age of 1-month. Histopathologic examination revealed an intraepidermal bulla produced by acantholysis and neutrophilic spongiosis. Direct immunofluorescence showed IgA deposits in the intercellular space throughout the epidermis. Circulating anti-intercellular IgA autoantibodies were absent. Dapsone therapy was effective.
Suzuki
Masayuki
M
Department of Dermatology, Jichi Medical School, Yakushiji Minamikawachimachi Kawachigun Tochigi, Japan. nemochi@jichi.ac.jp
Karube
Sachiko
S
Kobori
Youichi
Y
Usui
Keitaro
K
Murata
Satoru
S
Kato
Hideyuki
H
Nakagawa
Hidemi
H
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002974:Clemastine / Q000627:therapeutic use; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis*; D007223:Infant; D010392:Pemphigus / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D007070:Immunoglobulin A; D002974:Clemastine