[Spontaneous and Fas-induced apoptosis of mononuclear leukocytes in rheumatoid arthritis].
A study was made into the ability of mononuclear leukocytes recovered from blood of 77 patients with rheumatiod arthritis (RA), 17 patients with osteoarthrosis deformans (OAD), 18 patients with Chlamydia-associated reactive arthritis (ReA), and 20 healthy controls, to precipitate spontaneous and Fas-induced apoptosis. RA patients versus healthy persons and patients with OAD and ReA displayed lower parameters characterizing spontaneous and Fas-induced apoptosis. A correlation was established between the ability of T- and B-lymphocytes to usher in Fas-induced apoptosis during incubation with RhHA and KonA and degree of RA activity.
Petrov
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D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000276:immunology*; D016918:Arthritis, Reactive / Q000097:blood / Q000276:immunology / Q000382:microbiology; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D002690:Chlamydia Infections / Q000097:blood / Q000276:immunology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D010003:Osteoarthritis / Q000097:blood / Q000276:immunology; D000091402:Prohibitins; D012720:Severity of Illness Index; D019014:fas Receptor / Q000276:immunology*
D000911:Antibodies, Monoclonal; C000717331:PHB2 protein, human; D000091402:Prohibitins; D019014:fas Receptor