Effect of nutritive and tonic crude drugs on physical fatigue-induced stress models in mice.
The present study was undertaken to investigate the acute anti-fatigue effect of a liquid nutritive and tonic crude drugs (NTDs) on stress induced in mice. After forced walking for 3 or 6h, the NTDs (applied orally, 10 ml/kg) significantly increased locomotor activity, while the administration of NTDs after rapid eye movement (REM) sleep deprivation stress and after immobilization stress did not show a specific effect, having a similar effect as the vehicle with added vitamins, taurine and caffeine. The administration of NTDs after freezing due to electric shock stress showed a specific effect which was not seen in other control groups, water, vehicle (ethanol) and vehicle including vitamins, taurine and caffeine and so resemble the specific effect of NTDs in the stress of forced walking. The present results indicate that the NTDs produced an anti-fatigue effect on the decreased locomotor activity after forced walking and immobility induced by electric stimulation. However, the crude drugs were not effective in improving immobility after sleep deprivation or immobilization stress.
Tadano
Takeshi
T
Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. tadano@tohoku-pharm.ac.jp
Nakagawasai
Osamu
O
Niijima
Fukie
F
Tan-no
Koichi
K
Hanawa
Masa-aki
MA
Sakata
Yasuko
Y
Sutoo
Den'etsu
D
Nemoto
Yukio
Y
Ida
Yoshiteru
Y
Endo
Yasuo
Y
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004597:Electroshock; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology; D005615:Freezing; D007103:Immobilization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010805:Physical Conditioning, Animal / Q000502:physiology; D012892:Sleep Deprivation; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D016138:Walking / Q000502:physiology
D004365:Drugs, Chinese Herbal