[Effect of nifedipine, vitamin E, and bisphosphonates on intensity of lipid peroxidation in arterial and venous walls in hypervitaminosis D].
The peculiarities of lipid peroxydation (LPO) following injection of vitamin D in high doses (10,000 U/kg) and other agents (bisphosphanates, vitamin E, nifedipin) were examined in both arterial and venous walls of rabbits. It has been shown, that tan injection of the bisphosphanates didn't influence significantly the amount of both the intermediate and the final LPO products. Nifedipin did not change the intensity of LPO in the arterial vessels, but it limited the LPO reactions in the venous walls. Vitamin E decreased considerably an amount of the LPO products in all types of the vesselsunder exploration in the animals with hypervitaminosis D.
Harbuzova
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D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001158:Arteries / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D011817:Rabbits; D014680:Veins / Q000378:metabolism; D014807:Vitamin D / Q000008:administration & dosage*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D002121:Calcium Channel Blockers; D004164:Diphosphonates; D008054:Lipid Peroxides; C409217:ethane-1-hydroxy-1,1-bisphosphonate; D014807:Vitamin D; D014810:Vitamin E; D009543:Nifedipine