title: Genome scan for childhood and adolescent obesity in German families.
abstract: OBJECTIVE
  Several genome scans have been performed for adult obesity. Because single formal genetic studies suggest a higher heritability of body weight in adolescence and because genes that influence body weight in adulthood might not be the same as those that are relevant in childhood and adolescence, we performed a whole genome scan.
  
  
  METHODS
  The genome scan was based on 89 families with 2 or more obese children (sample 1). The mean age of the index patients was 13.63 +/- 2.75 years. A total of 369 individuals were initially genotyped for 437 microsatellite markers. A second sample of 76 families was genotyped using microsatellite markers that localize to regions for which maximum likelihood binomial logarithm of the odd (MLB LOD) scores on use of the concordant sibling pair approach exceeded 0.7 in sample 1.
  
  
  RESULTS
  The regions with MLB LOD scores >0.7 were on chromosomes 1p32.3-p33, 2q37.1-q37.3, 4q21, 8p22, 9p21.3, 10p11.23, 11q11-q13.1, 14q24-ter, and 19p13-q12 in sample 1; MLB LOD scores on chromosomes 8p and 19q exceeded 1.5. In sample 2, MLB LOD scores of 0.68 and 0.71 were observed for chromosomes 10p11.23 and 11q13, respectively.
  
  
  CONCLUSIONS
  We consider that several of the peaks identified in other scans also gave a signal in this scan as promising for ongoing pursuits to identify relevant genes. The genetic basis of childhood and adolescent obesity might not differ that much from adult obesity.
authors.affiliation: Molecular Genetics and Gene Mapping Center, Max Delbrück Center, Berlin, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Saar
authors.forename: Frank
authors.initials: F
authors.lastname: Geller
authors.forename: Franz
authors.initials: F
authors.lastname: Rüschendorf
authors.forename: André
authors.initials: A
authors.lastname: Reis
authors.forename: Susann
authors.initials: S
authors.lastname: Friedel
authors.forename: Nadine
authors.initials: N
authors.lastname: Schäuble
authors.forename: Peter
authors.initials: P
authors.lastname: Nürnberg
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Siegfried
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Goldschmidt
authors.forename: Helmut
authors.initials: H
authors.lastname: Schäfer
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Helmut
authors.initials: H
authors.lastname: Remschmidt
authors.forename: Anke
authors.initials: A
authors.lastname: Hinney
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009679:Nuclear Family; D009765:Obesity / Q000235:genetics*