Raised plasma oxidised LDL in acute cerebral infarction.
BACKGROUND
The association between oxidised low density lipoprotein (OxLDL) and cerebral infarction is suspected but not established.


OBJECTIVE
To determine whether plasma OxLDL is a useful marker for monitoring oxidative stress in stroke patients.


METHODS
Plasma OxLDL concentrations were determined in 56 stroke patients with cerebral infarction (n = 45) or cerebral haemorrhage (n = 11), and in 19 age matched controls, using a novel sandwich enzyme linked immunosorbent assay.


RESULTS
Compared with the controls (0.130 (0.007) ng/ micro g LDL, mean (SEM)), OxLDL was significantly raised in patients with cerebral infarction (0.245 (0.022); p < 0.0001) but not in those with haemorrhage (0.179 (0.023)). Patients with cortical ischaemic infarcts (n = 22) had higher OxLDL levels than either the controls (p < 0.0001) or the patients with non-cortical ischaemic infarcts (n = 23) (p < 0.001). Increased OxLDL concentrations in patients with cortical infarcts persisted until the third day after stroke onset. The National Institutes of Health stroke scales in patients with cortical infarction were higher than in those with non-cortical infarction (p < 0.01).


CONCLUSIONS
There is a significant association between raised plasma OxLDL and acute cerebral infarction, especially cortical infarction. Plasma OxLDL may reflect oxidative stress in stroke patients.
Uno
M
M
Department of Neurosurgery, School of Medicine, The University of Tokushima, Tokushima, Japan. muno@clin.med.tokushima-u.ac.jp
Kitazato
K T
KT
Nishi
K
K
Itabe
H
H
Nagahiro
S
S
D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002544:Cerebral Infarction / Q000097:blood* / Q000175:diagnosis; D002560:Cerebrovascular Circulation / Q000502:physiology; D008078:Cholesterol, LDL / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D008078:Cholesterol, LDL