The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.
The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
Chaudhury
Chaity
C
Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
Mehnaz
Samina
S
Robinson
John M
JM
Hayton
William L
WL
Pearl
Dennis K
DK
Roopenian
Derry C
DC
Anderson
Clark L
CL
D000818:Animals; D016466:CHO Cells; D002417:Cattle; D006224:Cricetinae; D006207:Half-Life; D015395:Histocompatibility Antigens Class I; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000378:metabolism; D066298:In Vitro Techniques; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011485:Protein Binding; D051381:Rats; D011961:Receptors, Fc / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism*
D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G; D011961:Receptors, Fc; D011994:Recombinant Proteins; D012710:Serum Albumin, Bovine; C100688:Fc receptor, neonatal