Spermicidal activity of the crude ethanol extract of Sedum praealtum in mice.
Ethanol extract of Sedum praealtum in intravaginal doses of 10, 20, 40, 50, 100 and 150 mg/kg body weight showed a toxic effect in spermatozoa viability after 24h of administration. Spermatozoa viability was 94, 83, 58 and 24%, respectively, for extract doses of 10, 20, 40 and 50mg/kg body weight, while only dead spermatozoa were found in the vagina of the treated female mice with doses of 100 and 150 mg/kg body weight.
Silva-Torres
Rafael
R
Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Apartado 42-186, México, D.F. 11340, Mexico. rafaelsilvatorres@hotmail.com
Montellano-Rosales
Hortensia
H
Ramos-Zamora
Delfina
D
Castro-Mussot
M Eugenia
ME
Cerda-García-Rojas
Carlos M
CM
D000282:Administration, Intravaginal; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D018547:Plant Stems; D031963:Sedum; D013089:Spermatocidal Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects
D010936:Plant Extracts; D013089:Spermatocidal Agents; D000431:Ethanol