[Study on syndrome pattern in insulin resistant model rats].
OBJECTIVE
To explore the Syndrome pattern in insulin resistant model rats.


METHODS
Eight Sprague-Dawley (SD) rats were induced to insulin resistance (IR) by 60% high-sucrose forage.


RESULTS
The correlative co-efficient of some biological and internal changes were clusterly analyzed and divided into 3 groups, which was closely related with phleg tubidity, blood stasis and internal toxin types respectively. The phlegm turbidity type was characterized by high content of blood lipid (triglyceride, total cholesterol) and high concentration of glycated serum protein; the blood stasis type was characterized by tendency of high viscosity and high coagulant state, the blood pressure increased, prothrombin time shortened, fibrinogen content raised and RBC and platelet count increased; while the internal toxin type was characterized by high content of glucose, insulin and the elevation of tumor necrosis factor.


CONCLUSIONS
The combined Syndrome of phlegm turbidity, blood stasis and internal toxin is the Syndrome-pattern in insulin resistant model rat. This observation provides theoretic basis for clinical and experimental studies of TCM.
Liang
X L
XL
First Affiliated Hospital, Anhui College of TCM, Hefei 230031.
Han
M X
MX
D000818:Animals; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D007333:Insulin Resistance; D008297:Male; D008516:Medicine, Chinese Traditional; D024821:Metabolic Syndrome; D051381:Rats; D017207:Rats, Sprague-Dawley