The complementary roles of deletion and regulation in transplantation tolerance.
Neonatal tolerance of alloantigens was described in mice nearly half a century ago, but unfortunately, the translation of these early findings into the clinical arena proved to be much more challenging than was first anticipated. However, the past decade has seen considerable progress in our understanding of the mechanisms that contribute to transplantation tolerance in experimental models. This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells.
Lechler
Robert I
RI
Department of Immunology, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Commonwealth Building, Du Cane Road, London W12 0NN, UK. r.lechler@ic.ac.uk
Garden
Oliver A
OA
Turka
Laurence A
LA
D000818:Animals; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007519:Isoantigens; D051379:Mice; D015778:Minor Histocompatibility Antigens; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
D007519:Isoantigens; D015778:Minor Histocompatibility Antigens