IRE1: a role in UPREgulation of ER degradation.
The unfolded protein response entered the mechanistic realm with the discovery of IRE1 as the key signal transducer in yeast. Although also found in mammals, it appeared to function in assisting the work of other players. The featured studies indicate a separate role for IRE1, and highlight the flexibility that bigger eukaryotes possess in this critical pathway.
Hampton
Randolph Y
RY
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92103, USA.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D004722:Endoribonucleases / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D015854:Up-Regulation
D008565:Membrane Proteins; C403982:ERN2 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases