title: Tuberculosis and HIV seroprevalence in Lambeth, Southwark and Lewisham, an area of South London.
abstract: Since the mid-1980s the number of cases of TB notified within the U.K. has continued to rise although the contribution of HIV to this rise remains unclear. A 12-month prospective cohort study was conducted at chest and HIV clinics in four hospitals in Lambeth, Southwark and Lewisham (LSL), an area of South London, to determine the proportion of patients with culture-proven TB infected with HIV. Secondary aims were to determine the proportion of patients with TB and undiagnosed HIV at first presentation to chest clinics, to determine the proportion of patients presenting with TB as an AIDS defining illness (ADI) and to identify risk factors for co-infection with TB and HIV. In chest clinics, demographic data and left-over blood from patients aged 16 or over with culture-proven TB was collected, anonymised and HIV tested. In HIV clinics, demographic data on patients with TB already known to be HIV seropositive were also obtained. Twenty-one patients (13%, 95% CI-8-19%) of 159 with culture-proven TB were infected with HIV Four (3%) of 133 patients at first presentation to chest clinics had undiagnosed HIV; two were subsequently diagnosed. Of the 21 patients withTB and HIV, nine (43%) presented with TB as an ADI. Patients with TB and HIV were significantly more likely to be aged between 35 and 55 years compared to HIV seronegative patients [12/21 (57%) vs. 38/138 (28%), P=0.006]. None of the patients from the Indian Subcontinent were HIV seropositive [0/21 vs. 25/138 (18%), P=0.047]. At the present time, universal HIV testing of patients with culture-provenTB in chest clinics within the U.K. is unlikely to significantly reduce the number of patients with undiagnosed HIV.
authors.affiliation: Department of Infection and Tropical Medicine, Northwick Park Hospital, Harrow, Middlesex, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Melzer
authors.forename: A
authors.initials: A
authors.lastname: Warley
authors.forename: H
authors.initials: H
authors.lastname: Milburn
authors.forename: D
authors.initials: D
authors.lastname: O'Sullivan
authors.forename: R D
authors.initials: RD
authors.lastname: Barker
authors.forename: D
authors.initials: D
authors.lastname: Hutchinson
authors.forename: D
authors.initials: D
authors.lastname: Shelton
authors.forename: F
authors.initials: F
authors.lastname: Drobniewski
authors.forename: G
authors.initials: G
authors.lastname: French
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D015528:HIV Seroprevalence; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology*