[Value of simultaneous determination of serum hyaluronic acid, collagen type IV and the laminin level in diagnosing liver fibrosis].
OBJECTIVE
To study the value of simultaneous determination of serum hyaluronic acid(HA), collagen Type IV (CIV) and the laminin (LN) level in the diagnosis of liver fibrosis.


METHODS
Serum HA, CIV and LN were measured by ELISA in 22 healthy persons, 10 cases of acute hepatitis, 10 cases of chronic hepatitis, 10 cases of heary chronic hepatitis, and another 25 cases of posthepatitic cirrhosis. The sensitivity, specificity and accuracy of simultaneous determination were compared with those of single determination in posthepatitic cirrhosis.


RESULTS
The levels of serum HA, CIV and LN in posthepatitic cirrhosis cases and heary chronic hepatitis cases were significantly higher than those in the other groups (P < 0.01). Simultaneous determination of these indices enhanced the diagnostic sensitivity, but decreased the diagnostic specificity.


CONCLUSIONS
Simultaneous determination of HA, CIV and LN can enhance the diagnostic sensitivity. Simultaneous determination of HA and CIV is an optimal choice.
Liang
Xiang-hui
XH
Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, China.
Zheng
Hui
H
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D024141:Collagen Type IV / Q000097:blood*; D005260:Female; D019694:Hepatitis B, Chronic / Q000175:diagnosis; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007797:Laminin / Q000097:blood*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D024141:Collagen Type IV; D007797:Laminin; D006820:Hyaluronic Acid