[Study on metabolism of preventive anti-fluorine agent on rats].
In order to study the metabolism of preventive anti-fluorine agent, 30 rats are randomly divided into high-dose, low-dose and a control groups. The high dose (400 mg/kg.d) and low dose (16 mg/kg.d) are orally administrated respectively, and the content of boron and/or zinc in urine, dung, serum, bone, liver, muscles, brain tissues is determined. The results showed that during the administration of this agent, the content of boron in urine and the content of zinc in dung increases obviously in both high-dose and low-dose groups and their discharge rate is consistent with the dose given. The content of boron and zinc in bone, liver, and zinc in serum, muscles, brain tissues increases evidently compared to that in control group but decreases rapidly after administration of the agent. The findings revealed that there is a rapid metabolism of boron and zinc in the body of rats. The highest content of the agent is observed in bones. The content ranks second in liver and muscles but no accumulative effects are observed.
Liu
Kejian
K
Institute of Occupational Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lu
Cuirong
C
Zheng
Hongyan
H
Zhang
Yuzeng
Y
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001895:Boron / Q000493:pharmacokinetics*; D005260:Female; D005458:Fluoride Poisoning / Q000378:metabolism*; D005459:Fluorides / Q000037:antagonists & inhibitors*; D008099:Liver / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D015032:Zinc / Q000493:pharmacokinetics*
D015032:Zinc; D001895:Boron; D005459:Fluorides