title: Malignant perivascular epithelioid cell tumor involving the prostate.
abstract: Perivascular epithelioid cell tumor (PEComa) is a neoplasm chiefly composed of HMB-45-positive epithelioid cells with clear-to-granular cytoplasm and a perivascular distribution. We describe such a tumor involving the prostate and seminal vesicle in a 46-year-old man. The tumor had characteristic histologic features of PEComa. Immunohistochemically, the tumor cells were positive for HMB-45 but negative for epithelial markers, Melan-A, and S100 protein. The tumor behaved in a malignant fashion, and the patient died of the disease 4 years after diagnosis.
authors.affiliation: Department of Pathology, National Yang-Ming University, and Veterans General Hospital-Taipei, Taipei, Taiwan. ccpan@vghtpe.gov.tw
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Pan
authors.forename: An-Hang
authors.initials: AH
authors.lastname: Yang
authors.forename: Hung
authors.initials: H
authors.lastname: Chiang
mesh_terms: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000276:immunology; D015622:Epithelioid Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008297:Male; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D009418:S100 Proteins / Q000276:immunology; D012669:Seminal Vesicles / Q000473:pathology; D018235:Smooth Muscle Tumor / Q000175:diagnosis; D019043:Vascular Neoplasms / Q000175:diagnosis*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins