[Expression and clinical implication of multidrug resistant-associated protein gene (MRP) in patients with laryngeal squamous cell carcinoma].
OBJECTIVE
To study the relationship between the expression of MRP mRNA and the clinical pathological characteristics of the patients with laryngeal squamous cell carcinoma.


METHODS
Reverse transcription polymerase chain reaction (RT-PCR) assay was used to detect the expression of MRP mRAN in 35 patients.


RESULTS
The positive expression rate of MRP mRAN was 45.7 percent (16/35) in laryngeal carcinoma. It was higher in advanced (T3-4) patients than that in early (T1-2) cases (P < 0.05) and showed a significant correlation with metastases of cervical lymph node (P < 0.01).


CONCLUSIONS
It is suggested that the expression of MRP mRNA may not only play an important role in multidrug resistance of laryngeal carcinoma, but also influence their biological behavior of dissemination and metastases.
Cai
X
X
State of Otorhinolaryngeal of Medical Health Department, Jinan 250012.
Wang
T
T
Fan
X
X
Dong
P
P
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis* / Q000235:genetics; D009362:Neoplasm Metastasis; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012333:RNA, Messenger