title: Synergy of binary poly(oxypropylene-oxyethylene) copolymers in reducing retention of Streptococcus sanguis to hydroxyapatite.
abstract: Binary poly(oxypropylene-oxyethylene) block copolymer systems have been investigated as a non-bactericidal approach to reduce the retention of an oral bacterium, Streptococcus sanguis. Using a previously validated hydroxyapatite-coated microtitre model to simulate the tooth, the performance of copolymer pairs was measured experimentally. A synergy index and an efficacy index were defined to describe the reduction of bacterial retention by the binary systems that comprise the copolymer pairs. Relationships between the synergy and efficacy indices and their associated compositions are given. The results obtained have been rationalised using a previously developed theoretical approach in conjunction with the binding energetics of species to surfaces.
authors.affiliation: University of Sheffield and Boots National Centre for Applied Research into Oral Health, School of Clinical Dentistry, Sheffield, UK. y.h.guan@shaf.ac.uk
authors.forename: Y H
authors.initials: YH
authors.lastname: Guan
authors.forename: T H
authors.initials: TH
authors.lastname: Lilley
authors.forename: D L
authors.initials: DL
authors.lastname: Lath
authors.forename: I
authors.initials: I
authors.lastname: Marlow
authors.forename: A H
authors.initials: AH
authors.lastname: Brook
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D004357:Drug Synergism; D017886:Durapatite; D016018:Least-Squares Analysis; D008956:Models, Chemical; D011060:Poloxalene / Q000494:pharmacology*; D013298:Streptococcus sanguis / Q000187:drug effects* / Q000502:physiology; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: D013501:Surface-Active Agents; D011060:Poloxalene; D017886:Durapatite