High dose chemotherapy and allogenic peripheral blood stem cell transplantation for multiple myeloma evolving from intra-abdominal plasmacytoma.
Solitary plasmacytomas include extramedullary plasmacytomas and those found in the bone. Seventy percent of patients are male and the median age is 50-55 years, younger than that for plasma cell myeloma. Most solitary plasmacytomas of bone eventually evolve to plasma cell myeloma within 2-10 years, while the extramedullary ones do so infrequently. We present an unusual case of intra-abdominal plasmacytoma in a young woman which was misdiagnosed and treated as T cell lymphoma initially. Typical manifestations of plasma cell myeloma appeared one year later. High dose chemotherapy followed by allogeneic peripheral stem cell blood transplantation (allo-PBSCT) was given. Relapse in skin occurred one year after allo-PBSCT, and was treated with wide excision and local irradiation. The patient was well and alive without evidence of disease 4 years after wide excision of the recurrence of chest wall solitary plasmacytoma and local radiotherapy.
Chung
Kun-Ming
KM
Division of Hematology and Oncology, Department of Internal Medicine, Tainan, Taiwan, ROC. jong4331@hotmail.com
Chuang
Shih-Sung
SS
Hwang
Wei-Shou
WS
Lee
Po-Shing
PS
Li
Chin-Yang
CY
D000008:Abdominal Neoplasms / Q000150:complications*; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000628:therapy*; D010954:Plasmacytoma / Q000150:complications*; D011239:Prednisolone / Q000008:administration & dosage; D014184:Transplantation, Homologous
D011239:Prednisolone; D008558:Melphalan