Nerve anastomosis with glue: comparative histologic study of fibrin and cyanoacrylate glue.
The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.
Wieken
K
K
European Hand Institute, 13 rue Blaise Pascal, 54320 Maxéville-Nancy, France.
Angioi-Duprez
K
K
Lim
A
A
Marchal
L
L
Merle
M
M
D000818:Animals; D003487:Cyanoacrylates / Q000009:adverse effects / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005355:Fibrosis; D005549:Foreign-Body Reaction / Q000139:chemically induced; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries* / Q000473:pathology; D014014:Tissue Adhesives / Q000627:therapeutic use*
D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; C421460:glubran