title: Serum sialic acid, a possible cardiovascular risk factor is not increased in Fijian Melanesians with impaired glucose tolerance or impaired fasting glucose.
abstract: BACKGROUND
  Serum total sialic acid (TSA) has been shown to be a strong cardiovascular risk factor with increased concentrations being associated with increased mortality. Serum TSA is also elevated in patients with type 2 diabetes including those with micro- and macrovascular complications. We wished, therefore, to test the hypothesis that serum TSA may be abnormal in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), in Fijian Melanesians.
  
  
  METHODS
  Twenty-one subjects with IGT (17 women and four men) were recruited along with 20 subjects with IFG (14 women and six men) and 22 normal subjects (12 women and 10 men). Serum TSA was 2.18 +/- 0.027 mmol//L, 2.19 +/- 0.033 mmol/L and 2.24 +/- 0-042 mmol/L in the three groups, respectively, which was not statistically different. Both systolic and diastolic blood pressure were, however, higher in the IGT group compared with the IFG and normal groups (P<0.04).
  
  
  CONCLUSIONS
  Serum TSA is not elevated in Fijian Melanesians with IGT and IFG although it is reported to be elevated in type 2 diabetes mellitus in other populations. Further research is needed to establish why serum TSA is a potent independent cardiovascular risk factor and is elevated in type 2 diabetes mellitus in some populations.
authors.affiliation: Department of Chemical Pathology, 5th Floor Tower Guy's and St Thomas' Hospital, London SE1 9RT, UK. martin.crook@gstt.sthames.nhs.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Crook
authors.forename: L
authors.initials: L
authors.lastname: Goldsmith
authors.forename: P
authors.initials: P
authors.lastname: Ameerally
authors.forename: P
authors.initials: P
authors.lastname: Lumb
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: Miell
authors.forename: D
authors.initials: D
authors.lastname: Russell-Jones
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D005367:Fiji / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D019158:N-Acetylneuraminic Acid