Successful treatment of enterovirus-induced myocarditis with interferon-alpha.
No randomized, placebo-controlled studies have investigated interferon-alpha therapy in enterovirus-proven myocarditis. This report describes 2 patients with enterovirus-induced myocarditis (1 with associated Churg-Strauss syndrome) who at follow-up endomyocardial biopsy showed clinical and hemodynamic improvement and viral clearance (using polymerase chain reaction) after interferon-alpha therapy.
Daliento
Luciano
L
Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy. luciano.daliento@unipd.it
Calabrese
Fiorella
F
Tona
Francesco
F
Caforio
Alida L P
AL
Tarsia
Giandomenico
G
Angelini
Annalisa
A
Thiene
Gaetano
G
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000150:complications; D004769:Enterovirus Infections / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D009206:Myocardium / Q000473:pathology; D011994:Recombinant Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins