[The protective immunity in mice immunized with FhGST or AsGST against Schistosoma japonicum cercariae].
OBJECTIVE
To study the protective immunity against Schistosoma japonicum (Sj) cercariae challenge in mice immunized with FhGST or AsGST.


METHODS
There groups of Kunming mice were immunized three times with rSjGST, FhGST and AsGST, respectively. Then 30 cercariae of Schistosoma japonicum were given per mouse by abdominal skin inoculation. Six weeks later, all mice were killed to collect adult worms, liver, spleen and large intestine for worm count and egg count.


RESULTS
The worm burden was reduced by 27.8%-36.4% in the three immune groups compared with the two control groups (P < 0.05). rSj26GST, FhGST and AsGST significantly decreased the number of eggs deposited in the tissues.


CONCLUSIONS
FhGST and AsGST could induce protection against S. japonicum cercariae infection.
Sun
W Y
WY
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025.
Liu
S X
SX
D000818:Animals; D017165:Ascaris suum / Q000201:enzymology*; D005210:Fasciola hepatica / Q000201:enzymology*; D005260:Female; D005982:Glutathione Transferase / Q000276:immunology*; D007114:Immunization; D007814:Larva / Q000276:immunology; D051379:Mice; D010270:Parasite Egg Count; D012549:Schistosoma japonicum / Q000276:immunology; D012554:Schistosomiasis japonica / Q000276:immunology / Q000517:prevention & control*
D005982:Glutathione Transferase