title: [Internal pharmacokinetical study on genistein chitosan microsphere capsule].
abstract: OBJECTIVE
  To compare the distribution of genistein chitosan microsphere capsule (M.C) in vivo in rats with that of genistein common capsule (C.C). To research slow-released target microsphere capsule.
  
  
  METHODS
  The study on pharmacokinetics of M.C and C.C were analyzed by HPLC and 3P97 software.
  
  
  RESULTS
  The concentration of M.C distributed among various organs decreased slower than those of C.C and were able to keep a certain concentration for a long time. Genistein common capsule mainly distributed in livers of rats, while genistein chitosan microsphere capsule distributed mainly in lungs and spleens of rats.
  
  
  CONCLUSIONS
  The chitosan microsphere capsule of genistein has better slow-release and has tendency to distribute in lungs and spleens.
authors.affiliation: College of Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102.
authors.forename: Wanying
authors.initials: W
authors.lastname: Wu
authors.forename: Yungu
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D002686:Chitin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D048271:Chitosan; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D019833:Genistein / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism; D051379:Mice; D008863:Microspheres; D013154:Spleen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D002686:Chitin; D048271:Chitosan; D019833:Genistein