title: MRI feedback temperature control for focused ultrasound surgery.
abstract: A temperature feedback controller routine using a physical model for temperature evolution was developed for use with focused ultrasound surgery. The algorithm for the controller was a multi-input, single-output linear quadratic regulator (LQR) derived from Pennes' bioheat transfer equation. The controller was tested with simulated temperature data that had the same characteristics as those obtained with magnetic resonance imaging (MRI). The output of the controller was the appropriate power level to be used by the transducer. Tissue parameters estimated prior to the simulated treatments were used to determine the controller parameters. The controller performance was simulated in three dimensions with varying system parameters, and sufficient temperature tracking was achieved. The worst-case overshoot was 7 degrees C and the steady-state error was 5 degrees C. The simulated behaviour of the controller suggests satisfactory performance and that the controller may be useful in controlling the power output during MRI-monitored ultrasound surgery.
authors.affiliation: Radiology Department, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
authors.forename: A
authors.initials: A
authors.lastname: Vanne
authors.forename: K
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D003198:Computer Simulation; D004867:Equipment Design / Q000379:methods; D019544:Equipment Failure Analysis / Q000379:methods; D005246:Feedback; D006801:Humans; D018499:Linear Energy Transfer; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*; D011786:Quality Control; D013696:Temperature; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*