title: Bacterial RNA polymerases: the wholo story.
abstract: Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA polymerase holoenzyme as it goes through the steps of transcription initiation. Comparisons with structural analyses of evolutionarily unrelated RNA polymerases reveal unexpected general features of the initiation process.
authors.affiliation: The Rockefeller University, Box 224, 1230 York Avenue, New York, NY 10021, USA.
authors.forename: Katsuhiko S
authors.initials: KS
authors.lastname: Murakami
authors.forename: Seth A
authors.initials: SA
authors.lastname: Darst
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D003461:Crystallography / Q000379:methods; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry* / Q000378:metabolism; D020035:Holoenzymes / Q000737:chemistry / Q000378:metabolism; D046911:Macromolecular Substances; D008958:Models, Molecular; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012313:RNA / Q000096:biosynthesis / Q000737:chemistry*; D012808:Sigma Factor / Q000737:chemistry* / Q000378:metabolism; D013824:Thermus / Q000737:chemistry* / Q000201:enzymology / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D020035:Holoenzymes; D046911:Macromolecular Substances; D012808:Sigma Factor; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases