Central nervous system activity of the methanol extract of Ficus platyphylla stem bark.
The central nervous system (CNS) activity of the methanolic extract of Ficus platyphylla stem bark was studied on locomotor activity, pentobarbital sleeping time, exploratory behaviour, amphetamine-induced hyperactivity, apomorphine-induced stereotypy, active-avoidance and performance on tread mills (rota-rod), using mice and rats. The results revealed that the extract significantly reduced the locomotor and exploratory activities in mice, prolonged pentobarbital sleeping time in rats, attenuated amphetamine-induced hyperactivity and apomorphine-induced stereotypy in mice, dose-dependently. The extract significantly suppressed the active-avoidance response in rats, with no significant effect on motor co-ordination as determined by the performance on rota-rod. The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
Chindo
B A
BA
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), P.M. B. 21, Abuja, FCT, Nigeria.
Amos
S
S
Odutola
A A
AA
Vongtau
H O
HO
Abbah
J
J
Wambebe
C
C
Gamaniel
K S
KS
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D030681:Ficus; D008297:Male; D000432:Methanol; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D002491:Central Nervous System Agents; D010936:Plant Extracts; D000432:Methanol