title: Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
abstract: Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC(50) of 0.42, 0.38 and 0.22 microM, respectively.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com
authors.forename: Vinod R
authors.initials: VR
authors.lastname: Hegde
authors.forename: Mohindar S
authors.initials: MS
authors.lastname: Puar
authors.forename: Ping
authors.initials: P
authors.lastname: Dai
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Gullo
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Jack
authors.initials: J
authors.lastname: Silver
authors.forename: Birendra N
authors.initials: BN
authors.lastname: Pramanik
authors.forename: Chung-Her
authors.initials: CH
authors.lastname: Jenh
mesh_terms: D018122:B7-1 Antigen / Q000187:drug effects*; D001667:Binding, Competitive / Q000187:drug effects; D018106:CD28 Antigens / Q000187:drug effects*; D002733:Chlorophenols / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D018122:B7-1 Antigen; D018106:CD28 Antigens; D002733:Chlorophenols; D010455:Peptides; D010456:Peptides, Cyclic; C476380:SCH204698; C476382:SCH79235; C476381:SCH79236; C090485:chloropeptin I; C023490:complestatin