[Effect of bushen huayu composite on secretion of lymphocytic interleukin-2 and interleukin-2 receptor expression in the aged].
OBJECTIVE
To study the effect of Bushen Huayu Composite (BSHY) on interleukin-2 (IL-2) secretion and IL-2 receptor expression in the aged.


METHODS
IL-2 was examined by methyl thiazolyl tetrazolium (MTT) method and IL-2 dependent cellular stains, IL-2 receptor expression was examined by FACS-indirect immunofluorescence.


RESULTS
Aging could result in the decrease in lymphocytic IL-2 secretion and IL-2 receptor expression (P < 0.01, P < 0.05), which could be improved by BSHY (P < 0.01, P < 0.05).


CONCLUSIONS
BSHY has significant up-regulatory effect on immune function of lymphocytes in the aged.
Wang
Rong-rong
RR
Department of Integrated Traditional and Western Medicine, First Hospital of Peking University, Beijing 100084.
Liu
Su-bin
SB
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D015375:Receptors, Interleukin-2 / Q000097:blood*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015375:Receptors, Interleukin-2