Peripheral clear cell variant of calcifying epithelial odontogenic tumor: Report of a case and immunohistochemical investigation.
A case of peripheral calcifying epithelial odontogenic tumor, clear cell variant, located on the right gingival maxilla of a 48-year-old woman, presenting as a 2.0-cm solitary, firm nodule was studied. Microscopically, it was composed of polyhedral and clear epithelial cells associated with amyloid-like deposition. The clear epithelial cells exhibited granules that were positive for periodic acid-Schiff, and the amyloid-like deposit stained with Congo red showed a green birefringence in the polarized light. Polyhedral and clear epithelial cells were immunopositive for AE1/AE3 and cytokeratin 14. Immunoexpression of fibronectin and types I and III collagen were different between the amyloid-like deposits and the connective tissue stroma. Tenascin surrounded epithelial cells located inside the amyloid-like deposits. Laminin and type IV collagen were immunodetectable around the strands, cords, and nests of epithelial cells. This report represents the seventh case of peripheral calcifying epithelial odontogenic tumor, clear cell variant.
Mesquita
Ricardo Alves
RA
São Paulo University, Department of Oral Pathology, Brazil.
Lotufo
Monica Andrade
MA
Sugaya
Norberto Nobuo
NN
De Araújo
Ney Soares
NS
De Araújo
Vera Cavalcanti
VC
D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008437:Maxilla; D008875:Middle Aged; D018333:Odontogenic Cyst, Calcifying / Q000737:chemistry / Q000473:pathology*; D009808:Odontogenic Tumors / Q000737:chemistry / Q000473:pathology*
D016326:Extracellular Matrix Proteins