title: [Clinical study on effect of tongyu no. I in improving prethrombotic state of senile diabetes mellitus].
abstract: OBJECTIVE
  To explore the therapeutic mechanism of Tongyu No. I (TY-1) in improving prethrombotic state of senile diabetes mellitus.
  
  
  METHODS
  Sixty-two patients of diabetes mellitus with prethrombotic state and blood-stasis Syndrome were selected and divided randomly into two groups, 32 in the treated group and 30 in the control group. The two groups were treated by conventional therapy, combined with additional TY-1 (treated group) and aspirin (control group) respectively for 2 months. And the clinical effect as well as relevant criteria in both groups before and after treatment were observed.
  
  
  RESULTS
  In the treated group, treatment showed markedly effective in 14 cases, effective in 16 and ineffective in 2, the total effective rate being 93.8%. In the control group, the corresponding values were 6, 14, 10 and 66.7% respectively. Comparison of the total effective rate in the two groups showed significant difference (P < 0.01). After treatment, the treated group showed lowering in plasma TXB2 similar to that in the control group, while the decrease of GMP-140 and fasting blood glucose levels was significant as compared with before treatment (P < 0.01) and the difference was significant between the two groups (P < 0.05) after treatment.
  
  
  CONCLUSIONS
  TY-1 could improve the prethrombotic state and blood-stasis Syndrome in patients of diabetes mellitus, the main therapeutic mechanism might be correlated to the lowering of GMP-140 content.
authors.affiliation: Affiliated Longhua Hospital of Shanghai TCM University, Shanghai 200032.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Zhu
authors.forename: J M
authors.initials: JM
authors.lastname: Song
authors.forename: S H
authors.initials: SH
authors.lastname: He
mesh_terms: D000368:Aged; D001809:Blood Viscosity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis
chemical_list: D004365:Drugs, Chinese Herbal; D010980:Platelet Membrane Glycoproteins; D013925:Thromboplastin