title: Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities.
abstract: Four new chalcone derivatives (1, 4, 7, 10) were isolated from the stem bark of Millettia leucantha KURZ (Leguminosae) along with two known ones (2, 6) and five known flavones (3, 5, 8, 9, 11). Structure elucidation and unambiguous assignment of the isolates were achieved with the aid of 1D and 2D NMR extensive studies. Correlation of 10 to 4 was successfully done by reduction with Et(3)SiH/CF(3)CO(2)H. Moderate cytotoxic activity was observed in chalcones (1, 10), whereas dihydrochalcones (4, 6) showed moderate anti-Herpes Simplex Virus (HSV) activity. Interestingly, flavone 8 showed significant anti-inflammatory effects inhibiting both cyclooxygenase (COX)-1 and -2.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Japan.
authors.forename: Ampai
authors.initials: A
authors.lastname: Phrutivorapongkul
authors.forename: Vimolmas
authors.initials: V
authors.lastname: Lipipun
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Kanyawim
authors.initials: K
authors.lastname: Kirtikara
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Sakiko
authors.initials: S
authors.lastname: Maruyama
authors.forename: Toshiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002599:Chalcone / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D002522:Chlorocebus aethiops; D006801:Humans; D051379:Mice; D033641:Millettia / Q000633:toxicity*; D024301:Plant Bark / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D018547:Plant Stems / Q000633:toxicity; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002599:Chalcone