[Correlations of Ki-67 expression and histopathologic characteristics in uveal melanomas].
OBJECTIVE
To investigate the relations between the cellular proliferation and histopathologic variables in paraffin embedded uveal melanomas with the using of the monoclonal antibody Ki-67 as a proliferation marker.


METHODS
Fifty-seven enucleated eyes were included for histopathological study and Ki-67 immunostaining. All these eye globes were enucleated between 1988 and 1997 without prior treatment.


RESULTS
The score of Ki-67 index ranged from zero to 4.89%, mean (0.75 +/- 1.02) %. The mean score of Ki-67 was significantly higher in large tumors (P = 0.007) or in tumors that contained epithelioid cells (P = 0.037) when compared to medium size tumors or to spindle cell type tumors. There was a significant difference of the distribution of epithelioid cell and spindle cell when compared histologic cell type with tumor size (chi 2 = 4.528, P < 0.05). Higher proportions of large tumors were found in epithelioid cell group. No significant correlation was found between the Ki-67 index and tumor location, scleral extension and age.


CONCLUSIONS
The Ki-67 index is significantly correlated with the histologic cell type and tumor size.
Liang
J
J
Department of Ophthalmology, People's Hospital of Beijing Medical University, Beijing 100044, China.
Yi
C
C
Schilling
H
H
Li
X
X
D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008545:Melanoma / Q000276:immunology / Q000473:pathology*; D008940:Mitotic Index; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D014604:Uveal Neoplasms / Q000276:immunology / Q000473:pathology*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen