[Influence of icariin on cell membrane of highly metastatic human lung tumor cell line].
In this study, flow cytometry (FCM) and fluorescent probe technique were used to explore the influence of icariin (ICA) on cell membrane of PG. The data suggested that ICA could inhance membrane fluidity of PG and increase the expression of membrane HLA-ABC antigen. This could be one of the anticancer mechanisms of ICA.
Mao
H
H
Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan 250062.
Zhang
L
L
Wang
Y
Y
Wen
P
P
Cui
S
S
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D018286:Carcinoma, Giant Cell / Q000473:pathology; D002462:Cell Membrane / Q000276:immunology; D034181:Epimedium / Q000737:chemistry; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008560:Membrane Fluidity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D006680:HLA Antigens; C056599:icariin