title: Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.
abstract: The present paper deals with the modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy (N). Excellent results are obtained in multiple regression analysis upon introduction of indicator parameters. The results are critically discussed on the basis of statistical data obtained from regression analysis.
authors.affiliation: QSAR and Computer Chemical Laboratories, A.P.S. University, Rewa 486 003, India. vijay-agrawal@lycos.com
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: Padmakar V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D000465:Algorithms; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray; D007700:Kinetics; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013816:Thermodynamics
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides