[Experimental study on protective effective of congsheng capsule in acute cerebral ischemia and improvement of cerebral blood flow and energy metabolism].
OBJECTIVE
To investigate the protective effect of Congsheng capsule (CSC) on acute cerebral ischemia in mice and rats.


METHODS
Cerebral ischemia model was established by adding FeCl3 to block the blood flow of unilateral middle cerebral artery (MCA) for 30 mins. Acute incomplete cerebral ischemia was induced by ligation of bilateral carotid arteries in rats. Bilateral carotid arteries of old mice were repeatedly ischemia and reperfusion combined with caudal bloodletting to build the cerebral ischemia model. The effect of CSC on neurologic symptom, cerebral infarction size, cerebral water content, cerebral blood flow and cerebral tissue energy metabolism were observed.


RESULTS
CSC 1, 3, 6 g/kg obviously reduce the size of cerebral infarction and cerebral water content, markedly improve the neurological symptoms and cerebral blood flow; 3, 6 g/kg significantly ameliorate the energy burden.


CONCLUSIONS
CSC has anti-cerebral ischemia function through increasing blood supply of cerebral tissue and improve the energy metabolism.
Zhao
L
L
Beijing University of TCM, Beijing 100029.
Xu
Q P
QP
Tang
M K
MK
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology*; D002214:Capsules; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism
D002214:Capsules; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents