Preparation, characterization & anticancer evaluation of potassium N-(p-anisole)-alpha-(2-xanthatophenyl)nitrone.
The new compound, Potassium-N-(p-anisole)-alpha-(2-xanthato-phenyl)nitrone of the formula K(p-MeOC6H4)N(O) ? CH(O-C6H4CS2) was prepared and characterized by elemental analysis, infrared, UV spectra and 1HNMR spectroscopy. The anticancer activity of it has been achieved by the National Cancer Institute (NCI) U.S.A. A remarkable activity was exhibited against nine types of cancer cells specially the colon, ovarian and CNS cancer.
Khallow
K I
KI
College of Education, Dept. of Chemistry, University of Mosul, Mosul, Iraq.
Ezzat
S S
SS
al-Omari
N A
NA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007097:Imines; C472369:N-(4-anisole)-alpha-(2-xanthatophenyl)nitrone; D013871:Thiones