Effects of DDAVP administrated subcutaneously in dogs with aspirin-induced platelet dysfunction and hemostatic impairment due to chronic liver diseases.
To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 microg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 +/- 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.
Sakai
Manabu
M
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.
Watari
Toshihiro
T
Miura
Teruhisa
T
Maruyama
Haruhiko
H
Koie
Hiroshi
H
Yamaya
Yoshiki
Y
Takeuchi
Akira
A
Hasegawa
Atsuhiko
A
D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects; D001791:Blood Platelet Disorders / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005169:Factor VIII; D006487:Hemostasis / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008107:Liver Diseases / Q000150:complications* / Q000662:veterinary*
D005169:Factor VIII; D003894:Deamino Arginine Vasopressin; D001241:Aspirin