title: Transmission of HCV infection among long-term hospitalized onco-haematological patients.
abstract: Hepatitis C virus (HCV) infection is becoming a substantial problem in long-term hospitalized patients. Onco-haematological patients undergoing chemotherapy are especially prone to HCV infection. These patients are usually immunosuppressed and therefore antibodies to HCV are not produced despite the presence of HCV RNA in peripheral blood. The aim of the study was to see how often long-term hospitalized patients acquired HCV infection, and what were the possible sources and routes of virus transmission. The study involved 129 children with lymphoproliferative diseases, 36 patients with solid tumours, and 61 healthcare workers from onco-haematological wards. All were HCV RNA and anti-HCV negative at the time of first hospitalization. During a two and a half-year follow-up study among 165 onco-haematological patients, HCV RNA appeared in 87 in subsequent hospitalizations. The majority of infections were (82/87) were 1a genotype, 2 were 1b, 1 was 1a + 1b and 1 was 1a + 3a. In an attempt to establish the origin of HCV infection, healthcare workers were screened for HCV genotyping. All HCV-infected staff working on wards had the same genotype (1a). None of the staff was infected with 1b genotype. As the most prevalent genotype in Polish blood donors is 1b, HCV infection in onco-haematological patients is most likely due to horizontal transmission, probably involving genotype 1a, and potential horizontal transmission of HCV is implied by the presence of 1a genotype of HCV in saliva and urine of selected patients. Spread of hospital HCV infection among children may be facilitated by micro-injury of the skin and mucosa. Early detection of HCV RNA is important in such immunosuppressed patients, as they are not able to produce anti-HCV antibodies. This may enable the introduction of prophylactic steps to prevent the spread of HCV infection by horizontal transmission.
authors.affiliation: Institute of Human Genetics Polish Academy of Sciences, Poznań, Poland. janusz@man.poznan.pl
authors.forename: D
authors.initials: D
authors.lastname: Januszkiewicz-Lewandowska
authors.forename: J
authors.initials: J
authors.lastname: Wysocki
authors.forename: J
authors.initials: J
authors.lastname: Rembowska
authors.forename: M
authors.initials: M
authors.lastname: Pernak
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
authors.forename: T
authors.initials: T
authors.lastname: Nowak
authors.forename: K
authors.initials: K
authors.lastname: Nowicka-Kujawska
authors.forename: J
authors.initials: J
authors.lastname: Nowak
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D003428:Cross Infection / Q000235:genetics*; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000175:diagnosis / Q000635:transmission*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007902:Length of Stay; D009369:Neoplasms / Q000188:drug therapy; D010564:Personnel, Hospital; D016133:Polymerase Chain Reaction
chemical_list: D000914:Antibodies, Viral