title: Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis.
abstract: Extrahepatic portal vein thrombosis (EHPVT) is associated with abnormal circulating procoagulants and anticoagulants. Eleven children with EHPVT and abnormal coagulation factors underwent a mesenterico-left portal vein bypass to restore portal flow. Coagulation factors had returned to normal by one year. The data suggest that portal venous flow is essential for maintaining normal coagulation.
authors.affiliation: Departments of Pediatrics and Surgery, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA.
authors.forename: Cara L
authors.initials: CL
authors.lastname: Mack
authors.forename: Riccardo A
authors.initials: RA
authors.lastname: Superina
authors.forename: Peter F
authors.initials: PF
authors.lastname: Whitington
mesh_terms: D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000209:etiology*; D002648:Child; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008102:Liver Circulation; D008297:Male; D010314:Partial Thromboplastin Time; D011168:Portal System; D011169:Portal Vein; D011170:Portasystemic Shunt, Surgical / Q000379:methods*; D011446:Prospective Studies; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; D017293:Protein S; C036309:fibrin fragment D; D000990:Antithrombin III; D005165:Factor V; D005167:Factor VII; D011516:Prothrombin; D005169:Factor VIII