[Observation on treatment of ectopic pregnancy by combination therapy of Chinese herbal medicine with mifepristone or methotrexate].
OBJECTIVE
To find a simpler, effectiver with less side-effect method for treatment of ectopic pregnancy.


METHODS
One hundred and fourteen patients of ectopic pregnancy were divided into two groups, the 56 patients in Group A were treated with Mifepristone and Chinese herbal medicine (CHM), and 58 patients in Group B were treated with Methotrexate and CHM. The therapeutic effect in both groups was observed and compared.


RESULTS
The rate of success in Group A was 82.14% and in Group B 70.69%, comparison between them showed no significance (P > 0.05). Time for successful treatment was 14.54 +/- 5.87 days in Group A and 9.00 +/- 5.09 days in Group B, comparison of them showed significant difference (P < 0.01). Insignificance revealed in comparison between the occurrence of side-effects for the groups, such as nausea, vomiting, diarrhea, liver dysfunction and lowering of white blood cells, but significance was shown in re-menstruation time (43.43 +/- 1.77 days vs 38.38 +/- 1.13 days, P < 0.05).


CONCLUSIONS
Treatments of combined CHM with Mifepristone or Methotrexate showed similar therapeutic effect in treating ectopic pregnancy, but the latter showed a quicker initiation and less side-effects in delaying the re-menstruation time.
Su
Ying
Y
Second Affiliated Hospital, Kunming Medical College, Kunming 650101.
Sun
Yan
Y
Ma
Lan
L
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000328:Adult; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D015735:Mifepristone / Q000627:therapeutic use*; D008517:Phytotherapy; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
D000019:Abortifacient Agents; D004365:Drugs, Chinese Herbal; D015735:Mifepristone; D008727:Methotrexate