[The inhibitory effect of selenite and other antioxidants on the complement mediated experimental pulmonary alveolitis].
OBJECTIVE
To test the regulatory effect of selenite and other antioxidants on complement PMN activation feedback mechanism mediated inflammatory response in experimantal pulmonary vasculitis.


METHODS
Mouse model of pulmonary Arthus reaction vasculitis developed with BSA sensitization and antigen inhalation was used for tests of inhibitory effect of oral administration of sodium selenite, glycyrrhizin flavonoids and/or vitamin E on the incidence of developing vasculitis, which could reflect the modulation of inflammatory response and tissue injury.


RESULTS
A remarkable inhibitory effect of selenite or combined flavonoid and vitamin E on the induction of pulmonary vasculitis were observed as the incidence of vasculitis could drop from 100% of the untreated group down to 25% of the antioxidants treated groups, revealing modulation of inflammatory response.


CONCLUSIONS
It indicated a newer insight into mechanism of the inflammatory response could give a novel approach to the modulation of inflammatory response. An adjuvant therapy of selenium and antioxidants to the interventions of inflammatory disorders has been expected.
Shi
X
X
Department of Pathology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing, 100005.
Lin
Y
Y
Hou
J
J
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003167:Complement Activation / Q000502:physiology*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000098:blood supply; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012710:Serum Albumin, Bovine; D018038:Sodium Selenite / Q000494:pharmacology*; D014657:Vasculitis / Q000139:chemically induced / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E; D012710:Serum Albumin, Bovine; D018038:Sodium Selenite