[Effect of sodium ferulate on leucocyte spontaneous activation and surface adhesion molecule expression in arteriosclerosis obliterans patients].
OBJECTIVE
To explore the effect of sodium ferulate (SF) on leucocyte spontaneous activation rate (LSAR) and the surface expression of adhesion molecule (SEAM) in patients with arteriosclerosis obliterans (ASO).


METHODS
Forty-two patients with ASO were treated by SF, LSAR and SEAM in them were determined qualitatively before and after SF treatment, as well as in 36 healthy subjects for control.


RESULTS
Therapeutic effect of SF in the treated 42 patients was short-term cured in 17 cases (40.5%), markedly effective in 21 (50%), effective in 2 (4.8%), ineffective in 2(4.8%), and the total effective rate being 95.2%. LSAR and SEAM in ASO patients before treatment was 14.84 +/- 7.54% and 47.94 +/- 13.48% respectively, which was obviously higher than 4.96 +/- 2.04% and 24.12 +/- 9.35% in healthy subjects (P < 0.01) respectively, but markedly reduced to 8.19 +/- 4.09% and 28.63 +/- 7.91% after SF treatment (P < 0.01).


CONCLUSIONS
SF could not only obviously lower both LSAR and SEAM but also exert a good therapeutic effect on patients with ASO.
Li
S Z
SZ
Hospital of Hematologic Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300020.
Huang
P P
PP
Jin
Y J
YJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000188:drug therapy*; D018845:CD11 Antigens / Q000096:biosynthesis*; D018821:CD18 Antigens / Q000096:biosynthesis*; D003373:Coumaric Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007962:Leukocytes / Q000378:metabolism* / Q000502:physiology; D008297:Male; D008875:Middle Aged
D000925:Anticoagulants; D018845:CD11 Antigens; D018821:CD18 Antigens; D003373:Coumaric Acids; C004999:ferulic acid