title: [Extra-gastrointestinal tract diseases and Helicobacter pylori infection].
abstract: Helicobacter pylori infection is linked to conditions of the upper gastrointestinal tract, including peptic ulcer and gastric adenocarcinoma na MALT lymphoma. It has also been associated with wide variety of extragastric and non-gastrointestinal conditions. However, the evidence in support of Helicobacter pylori infection as a cause of the non-gastrointestinal tract diseases is not widely understood. We reviewed the medical literature in regard to putative association of Helicobacter pylori infection and non-gastrointestinal tract condition, notably cardiovascular, autoimmune and dermatological diseases. The majority of published papers examining the potential causal relationship were case-control studies, cross-sectional and cohort studies while only a few recent articles that did not confirm the evidence of causal relationship represent well designed population-based prospective studies. The lack of clear evidence for etiopathogenetic associations of Helicobacter pylori infection and non-gastrointestinal tract conditions should focus our attention on appropriate testing and treatment of Helicobacter pylori infection in patients with conditions that are of proven association such as peptic ulcer disease.
authors.affiliation: Klinika za unutarnje bolesti, Klinicka bolnica Dubrava, Avenija Gojka Suska br. 6, 10000 Zagreb.
authors.forename: Marko
authors.initials: M
authors.lastname: Banić
authors.forename: Mladen
authors.initials: M
authors.lastname: Buljevac
authors.forename: Milan
authors.initials: M
authors.lastname: Kujundzić
authors.forename: Davor
authors.initials: D
authors.lastname: Jelić
authors.forename: Mara
authors.initials: M
authors.lastname: Dominis
authors.forename: Vesna
authors.initials: V
authors.lastname: Colić-Cvrlje
authors.forename: Dusko
authors.initials: D
authors.lastname: Kardum
authors.forename: Miroslava
authors.initials: M
authors.lastname: Katicić
mesh_terms: D001327:Autoimmune Diseases / Q000382:microbiology; D001660:Biliary Tract Diseases / Q000382:microbiology; D002318:Cardiovascular Diseases / Q000382:microbiology; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008107:Liver Diseases / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000382:microbiology