title: [Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria].
abstract: OBJECTIVE
  To observe the therapeutic efficacy of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria.
  
  
  METHODS
  Patients with Plasmodium falciparum were selected as the subjects, treated with a single dose of dihydroarteminisinin 160 mg combined with naphthoquine phosphate 400 mg (for adults) and followed up in preselective time by blood and temperature examination for 28 days after drug administration.
  
  
  RESULTS
  37 patients with falciparum malaria were treated and followed up. One patient had recrudescence and the cure rate in 28 days was 97.3%(36/37). The mean fever clearance time was (15.8 +/- 8.7) hours; the mean parasite clearance time was (27.6 +/- 13.2) hours; the mean reduction parasite rate in 24 hours was 96.7% +/- 26.5%. No apparent side effect was observed.
  
  
  CONCLUSIONS
  A combination of dihydroartemisinin and naphthoquine is effective for the treatment of patients with falciparum malaria.
authors.affiliation: Hainan Provincial Institute of Tropical Diseases, Haikou 570203.
authors.forename: Shan-qing
authors.initials: SQ
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Meng
authors.forename: Heng
authors.initials: H
authors.lastname: Shen
authors.forename: Yan
authors.initials: Y
authors.lastname: Wen
authors.forename: Kai-ren
authors.initials: KR
authors.lastname: Zhuo
authors.forename: Qi-xian
authors.initials: QX
authors.lastname: Zhu
authors.forename: Xue-jian
authors.initials: XJ
authors.lastname: Pang
authors.forename: Shi-gan
authors.initials: SG
authors.lastname: Lin
authors.forename: Lin-hai
authors.initials: LH
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C039060:artenimol