Coxsackie viral infection and orofacial cleft.
The incidence of orofacial cleft (OC) in newborns was compared with the occurrence of virus-neutralizing antibodies to coxsackie viruses in the serum of newborns and their mothers. No significant difference was found when comparing the seropositivity rates between the group of patients and the control group of healthy newborns. If the patients were divided according to the place of residence however, marked differences occurred between the regions. The lowest incidence of both--coxsackie infection and OC was determined in the region of Bratislava and the highest in the region of Zilina. The explanation of these findings recquires a more detailed analysis of genetic background, social and hygienic status, style of life and other factors, known to influence the development of OC as multi-etiological developmental disorder. (Tab. 2, Fig. 4, Ref. 12.).
Molnarova
A
A
Plastic Surgery Department, Faculty of Medicine, Comenius University, University Hospital Ruzinov, Bratislava, Slovakia.
Petrovicova
A
A
Fedeles
J
J
Bopegamage
S
S
Horakova
E
E
D000914:Antibodies, Viral / Q000097:blood*; D002971:Cleft Lip / Q000453:epidemiology / Q000821:virology*; D002972:Cleft Palate / Q000453:epidemiology / Q000821:virology*; D003384:Coxsackievirus Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D004770:Enterovirus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D018154:Slovakia / Q000453:epidemiology
D000914:Antibodies, Viral; D007075:Immunoglobulin M