title: Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics.
abstract: The three-dimensional structures of Haemophilus influenzae proteins whose biological functions are unknown are being determined as part of a structural genomics project to ask whether structural information can assist in assigning the functions of proteins. The structures of the hypothetical proteins are being used to guide further studies and narrow the field of such studies for ultimately determining protein function. An outline of the structural genomics methodological approach is provided along with summaries of a number of completed and in progress crystallographic and NMR structure determinations. With more than twenty-five structures determined at this point and with many more in various stages of completion, the results are encouraging in that some level of functional understanding can be deduced from experimentally solved structures. In addition to aiding in functional assignment, this effort is identifying a number of possible new targets for drug development.
authors.affiliation: Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA. gary.gilliland@nist.gov
authors.forename: Gary L
authors.initials: GL
authors.lastname: Gilliland
authors.forename: Alexey
authors.initials: A
authors.lastname: Teplyakov
authors.forename: Galina
authors.initials: G
authors.lastname: Obmolova
authors.forename: Maria
authors.initials: M
authors.lastname: Tordova
authors.forename: Narmada
authors.initials: N
authors.lastname: Thanki
authors.forename: Jane
authors.initials: J
authors.lastname: Ladner
authors.forename: Osnat
authors.initials: O
authors.lastname: Herzberg
authors.forename: Kap
authors.initials: K
authors.lastname: Lim
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Kui
authors.initials: K
authors.lastname: Huang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tempczyk
authors.forename: Wojiech
authors.initials: W
authors.lastname: Krajewski
authors.forename: Lisa
authors.initials: L
authors.lastname: Parsons
authors.forename: Deok Cheon
authors.initials: DC
authors.lastname: Yeh
authors.forename: John
authors.initials: J
authors.lastname: Orban
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Howard
authors.forename: Edward
authors.initials: E
authors.lastname: Eisenstein
authors.forename: James
authors.initials: J
authors.lastname: F  Parsons
authors.forename: Nicklas
authors.initials: N
authors.lastname: Bonander
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Fisher
authors.forename: John
authors.initials: J
authors.lastname: Toedt
authors.forename: Prasad
authors.initials: P
authors.lastname: Reddy
authors.forename: C V
authors.initials: CV
authors.lastname: Rao
authors.forename: Eugene
authors.initials: E
authors.lastname: Melamud
authors.forename: John
authors.initials: J
authors.lastname: Moult
mesh_terms: D016679:Genome, Viral; D006193:Haemophilus influenzae / Q000235:genetics* / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology
chemical_list: D014764:Viral Proteins