Responses of isolated scale melanophores of a fresh water carp, Cirrhinus mrigala (Ham.) to zidovudine.
Zidovudine (AZT) induced concentration related aggregation in C. mrigala melanophores. Denervated melanophores failed to respond to AZT. Specific and nonspecific alpha adrenoceptor antagonists completely blocked the responses of fish melanophores to AZT. Histamine and prostaglandin antagonists also inhibited aggregation of the melanophores induced by AZT. The results suggest that AZT may release a mixture of neurotransmitter like substances, which cause the aggregation of this fish melanophores.
Srivastava
Sudhir Kumar
SK
Department of Biosciences, Barkatullah University, Bhopal 462 026, India.
Ovais
M
M
D000320:Adrenergic Fibers; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002347:Carps; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D008547:Melanophores / Q000187:drug effects* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D019380:Anti-HIV Agents; D002121:Calcium Channel Blockers; D016861:Cyclooxygenase Inhibitors; D018492:Dopamine Antagonists; D006634:Histamine H1 Antagonists; D011985:Receptors, Serotonin; D015215:Zidovudine