title: Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.
abstract: A series of monocyclic delta-lactams (piperazones) was prepared and analysed as inhibitors of porcine pancreatic elastase and human neutrophil elastase.
authors.affiliation: The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, UK.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Seibel
authors.forename: David
authors.initials: D
authors.lastname: Brown
authors.forename: Augustin
authors.initials: A
authors.lastname: Amour
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Macdonald
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Oldham
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D000818:Animals; D003500:Cyclization; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D007769:Lactams / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013552:Swine
chemical_list: D007202:Indicators and Reagents; D007769:Lactams; D015842:Serine Proteinase Inhibitors; D010196:Pancreatic Elastase