[Virus interaction in HBV and HCV super infection].
OBJECTIVE
To investigate virus interaction in HBV and HCV superinfection.


METHODS
The changes of serum markers of 30 patients with HBV and HCV superinfetion were observed. Meanwhile, mutation of HBV precore region at nt 1,896 and the amount of TNF alpha and IL-6 in sera were also investigated.


RESULTS
Compared with HBV or HCV single infection, positive rates of HBeAg, HBV DNA and HCV RNA in superinfectim were lower, positive rates of anti-HBe was higher, the average titers of HBsAg, anti-HBcIgG and anti-HCV were significantly lower, too. In some patients, HBsAg were seronegatively convested. Occurrence rate of HBV precore region mutation at nt1896 and levels of TNF alpha and IL-6 in sera were higher in super infection than those in single infection.


CONCLUSIONS
Interference existed between HBV and HCV superinfection, conversion from HBeAg to anti-HBe was not only due to the suppression by HCV but also to the mutation of HBV precore region, and HCV may be a reason causing HBV precore region mutation through increasing the pressure of the body's immunosystem.
Zhang
L
L
Department of Infectious Diseases, 2nd Clinical College, China Medical University, Shenyang 110003.
Feng
G
G
Qiao
G
G
D000328:Adult; D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000235:genetics*; D006509:Hepatitis B / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009154:Mutation; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014762:Viral Interference / Q000235:genetics*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha