[Clinical and experimental study on separately decocted and mingly decocted jianweishu granule].
OBJECTIVE
To observe the difference in therapeutic effect of Chinese herbal granule decocted separately and mingly.


METHODS
One hundred patients of functional dyspepsia of Spleen deficiency and Liver stagnancy type were treated with Jianweishu Granule (JWSG, a self-formulated recipe by the author). Half of the patients received JWSG decocted separately, half of them received that decocted mingly. The therapeutic effects between the two groups were compared. Experimental observation on the effects of differently decocted remedies in rats was also conducted.


RESULTS
The therapeutic effects obtained in the two groups were similar, with respective cure rate of 72% and 70% and the total effective rate 96% in both group. There was insignificant difference between the two groups (P > 0.05). Experimental study all showed no difference between the differently decocted remedies in inhibiting gastric acid, pepsin activity, gastric function regulation, small intestine movement improvement and pain alleviation in rats.


CONCLUSIONS
The therapeutic effects of JWSG decocted separately or mingly are the same. This fact provides a scientific basis for clinical use of granule form of single Chinese herbs.
Ge
Yan
Y
Second Hospital of TCM, Guangdong Province, Guangzhou 510095.
Cui
Jing-chao
JC
Zhou
Rui-ling
RL
D000328:Adult; D000818:Animals; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008875:Middle Aged; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy; D016711:Yang Deficiency / Q000188:drug therapy
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal