title: [Clinical comparative trial of co-artemether and benflumetol (two formulations) in the treatment of falciparum malaria].
abstract: OBJECTIVE
  To observe the efficacy and safety of co-artemether and one of its components benflumetol (two formulations) in the treatment of patients with falciparum malaria.
  
  
  METHODS
  Adopting double-blining, randomization and comparative method, all patients were hospitalized and observed for 28 days after treatment.
  
  
  RESULTS
  Of 150 patients, 51 patients were treated with co-artemether group(A), 50-patients were treated with benflumetol tablet group(B), 49 patients were freated with benflumetol capsule group(C). The mean fever clearance times for groups A, B and C were 17.1 +/- 8.6, 34.0 +/- 23.2 and 29.4 +/- 24.9 hours, respectively; the mean parasite clearance times were 29.7 +/- 8.9, 51.6 +/- 14.1 and 54.7 +/- 17.4 hours respectively; the cure rates in 28 days for groups A, B and C were 98.2%, 92.0% and 95.8%, respectively. No apparent side-effect was observed.
  
  
  CONCLUSIONS
  Co-artemether and benflumetol (2 formulations) are effective for the treatment of patients with falciparum malaria but co-artemether is more effective than benflumetol (2 formulations) in terms of controlling symptoms and killing parasites.
authors.affiliation: Institute of Microbiology and Epidemiology, Academy of Millitary Medical Sciences, Beijing 100071.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Sun
authors.forename: C Q
authors.initials: CQ
authors.lastname: Shan
authors.forename: G F
authors.initials: GF
authors.lastname: Li
authors.forename: D B
authors.initials: DB
authors.lastname: Ding
authors.forename: G Y
authors.initials: GY
authors.lastname: Liu
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: X Q
authors.initials: XQ
authors.lastname: Jiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage*; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D004983:Ethanolamines / Q000008:administration & dosage*; D005449:Fluorenes / Q000008:administration & dosage*; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000008:administration & dosage*
chemical_list: D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D012717:Sesquiterpenes; D000078102:Lumefantrine