[The study on Rhizoma Alpiniae officinarum and other herbs as penetration enhancer for the permeation of 5-fluorouacil].
OBJECTIVE
To study the effects of volatile oils from Rhizoma Alpiniae Officinarum, Pericarpium Zanthoxyli, Herba Asari, cineaol and ethanol extracts on the percutaneous pentration of 5-fluorouracil.


METHODS
By Valia-Chienhorizontal diffusion cell and HPLC, the effects of volatile oils from Rhizoma Alpiniae Officinarum, Pericarpium Zanthoxyli, Herba Asari, cineol and ethanol extracts on the percutaneous penetration of 5-fluorouracil were observed and compared with azone.


RESULTS
1%, 3% volatile oils from Rhizoma Alpiniae Officinarum, Pericarpium Zanthoxyli and cineol possessed strong promoting action on percutaneous absorption of 5-fluorouracil. The effects of volatile oils from Rhizoma Alpiniae Officinarum was stronger than that of azone; the effects of volatile oils from Pericarpium Zanthoxyli was the same as that of azone. CONDUSION: The volatile oils from Rhizoma Alpiniae Officinarum, Pericarpium Zanthoxyli, Herba Asari can enhance effectively the skin permeation of 5-fluorouracil. They deserved to be researched and developed further.
Shen
Q
Q
Changhai Hospital, Second Military Medical University, Shanghai 200032.
Li
W
W
Xu
L
L
D000279:Administration, Cutaneous; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005472:Fluorouracil / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D012869:Skin Absorption / Q000187:drug effects*
D001381:Azepines; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D010938:Plant Oils; D005472:Fluorouracil