[Expression significance of P21WAF1/CIP1 protein in eye-lid primary malignant tumor].
OBJECTIVE
To study the expression of P21waf1/cip1 protein in eye-lip primary malignant tumor (E-LPMT).


METHODS
Immunohistochemical streptavidin biotin peroxidase complex(SP) method was used to stain section of E-LPMT.


RESULTS
In 61 cases of E-LPMT, positive expression of P21waf1/cip1 protein was found locating in the nuclei. In Cell carcinoma, Squamous and Adenocarcinomas, the positive rate of P21waf1/cip1 protein expression were 36.0%, 27.8% and 22.2% respectively. The positive rate of P21waf1/cip1 protein expression in well-differentiated Cell carcinomas or Adenocarcinomas was higher than in poor-differentiated ones (P < 0.01).


CONCLUSIONS
P21waf1/cip1 protein expresses in various type of E-IPMT and its positive expression in Cell carainomas and Adenocarcinomas are related to their different degrees.
Yue
H
H
Department of Ophthalmology, Lanzhou Military General Hospital, Lanzhou 730050, China.
Zhang
B
B
D000230:Adenocarcinoma / Q000737:chemistry; D014408:Biomarkers, Tumor; D002280:Basal Cell Carcinoma / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000096:biosynthesis* / Q000235:genetics; D005142:Eyelid Neoplasms / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis
D014408:Biomarkers, Tumor; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins