Linear IgA dermatosis induced by a new angiotensin-converting enzyme inhibitor.
A 68-year-old female patient treated with benazepril for arterial hypertension developed oral and cutaneous blistering. Biopsy of the oral and cutaneous lesions showed neutrophilic microabscesses in the mesenchymal papillae, with epitheliomesenchymal separation. Direct immunofluorescence revealed linear immunoglobulin deposits at the epithelial basement membrane zone, consisting predominantly of IgA. The histologic results supported the clinical diagnosis of drug-induced linear IgA disease. The substitution of benazepril with a beta blocker resulted in complete resolution of all mucocutaneous lesions.
Femiano
Felice
F
University of Medicine and Surgery, Eastman Dental Institute, London, United Kingdom. femiano@libero.it
Scully
Crispian
C
Gombos
Fernando
F
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001552:Benzazepines / Q000009:adverse effects*; D001768:Blister / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D019226:Oral Ulcer / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D010160:Palate, Soft / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D007070:Immunoglobulin A; C044946:benazepril