[Plasma branched-chain ketoacids metabolism in patients with chronic renal failure after oral administration of ketosteril].
OBJECTIVE
To investigate the metabolism of branched-chain ketoacids (BCKA) in patients with chronic renal failure (CRF) and healthy control after an oral dose of ketosteril.


METHODS
To determine plasma concentration of BCKA by gas chromatography/mass spectrography(GC/MS).


RESULTS
Fasting plasma concentration of ketoisocaproate (KICA) and ketomethylvalerate(KMVA) in patients with CRF were lower than that of healthy control; The Cmax of KICA, KMVA and ketoisovalerate (KIVA) were (67.7 +/- 12.9), (57.8 +/- 10.3), (30.3 +/- 5.3) mumol/L; Tmax were (43.8 +/- 5.7), (58.1 +/- 4.6), (43.8 +/- 4.5) min; T1/2 were (108.5 +/- 12), (105 +/- 16.6), (116.8 +/- 18) min respectively.


CONCLUSIONS
Absorption of BCKA in ketosteril had no significant difference between CRF patients and healthy controls; ketosteril could be used to treat CRF patients effectively.
Yang
H
H
Lab of Clinical Pharmacology, PUMC Hospital, CAMS and PUMC, Beijing 100730.
Zheng
F
F
Jiang
J
J
Hu
P
P
Li
X
X
D000284:Administration, Oral; D000328:Adult; D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D045782:Hemiterpenes; D006801:Humans; D007651:Keto Acids / Q000097:blood; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D000601:Amino Acids, Essential; D045782:Hemiterpenes; D007651:Keto Acids; C048995:ketosteril; C001505:alpha-ketoisovalerate; C013082:alpha-ketoisocaproic acid