[Synergy and attenuation of cyclophosphamidum (CTX) activities by abalone polysaccharide].
Abalone polysaccharide (AP) was extracted from Haliotis discushannai Ino. The combined effects of AP and CTX against tumor-bearing mice were investigated. The results showed that AP could markedly promote the inhibition effects of CTX on S180 and HepA tumor, enhance protection against leukocytopenia, decrease of spleen and thymus weight and hemolysin in serum, and bone marrow supression induced by CTX.
Wang
B
B
Zhongshan University, Guangzhou 510275.
Xu
D
D
Xu
S
S
Ling
Y
Y
Shao
Z
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000494:pharmacology; D003520:Cyclophosphamide / Q000009:adverse effects / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006460:Hemolysin Proteins / Q000097:blood; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008974:Mollusca / Q000737:chemistry; D009368:Neoplasm Transplantation; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D006460:Hemolysin Proteins; D008419:Materia Medica; D011134:Polysaccharides; D003520:Cyclophosphamide