The effect of gastric electrical stimulation on canine gastric slow waves.
This study determined the most efficient parameters of low-frequency/long-pulse gastric electrical stimulation (GES) required to entrain gastric slow waves and also evaluated the effect of entrainment and high-frequency, short-pulse GES on gastric electrical activity (GEA). Nine dogs were fitted with stimulation wires along the greater curvature. Entrainment was observed in six or seven animals, with long-pulse GES at six cycles per minute (cpm), at various combinations of current and pulse width and was directly related to the energy delivered. Entrainment was observed in four to seven animals, with GES at 12 cpm, and the maximal driven frequency was 6 cpm. Entrainment did not significantly increase the dominant power of GEA. High-frequency, short-pulse GES, using pulse trains of 14 Hz, 5 mA, and 330 micros, with 0.1 s on and 5 s off, and pulse trains of 40 Hz, 10 mA, and 330 micros, with 2 s on 3 s off, did not affect variables of GEA. We conclude that acute low-frequency GES but not high-frequency, short-pulse GES can entrain slow waves; the power of slow waves is not affected by either type of stimulation.
Xing
Jinhong
J
Gastroenterology, General Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Brody
Frederick
F
Rosen
Michael
M
Chen
J D Z
JD
Soffer
Edy
E
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D013270:Stomach / Q000502:physiology*; D013997:Time Factors