title: Mutation screening of the human period 2 gene in bipolar disorder.
abstract: We tested whether the human period 2 gene (hper2), one of the essential components of the circadian oscillator, might have influence on bipolar disorder. We screened 88 bipolar disorder patients and 127 controls, all of Japanese origin. Screening in the casein kinase I epsilon (CKIepsilon) binding region of hper2, which was previously reported in familial advanced sleep-phase syndrome patients, with polymerase chain reaction amplification revealed four polymorphisms. One of the four polymorphisms had an amino acid substitution of a serine at 662 with a glycine (S662G). The frequencies of the S662G allele and genotypes on patients with bipolar disorder were very low and had no difference from those in controls. Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder.
authors.affiliation: Department of Psychiatry, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Shiino
authors.forename: Satoru
authors.initials: S
authors.lastname: Nakajima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ozeki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Isono
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001665:Binding Sites / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics*; D047388:Casein Kinases; D004252:DNA Mutational Analysis; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D011110:Polymorphism, Genetic; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors
chemical_list: D009687:Nuclear Proteins; C421902:PER2 protein, human; D056950:Period Circadian Proteins; D011506:Proteins; D014157:Transcription Factors; D011494:Protein Kinases; D047388:Casein Kinases