[Study on the injury of liver induced by terephthalic acid ethylene glycol and/or dowtherm A in rats].
The joint injury actions and mechanisms of terephthalic acid (TPA), ethylene glycol (EG) and/or dowtherm A (DOW) on liver in rats were investigated. A subchronic toxicity study was designed by a 2(3) factorial method. Some enzymes, biochemical and morphologic indices reflecting the injury of liver were studied. The results showed that serum ALT and serum total bile acid (TBA) of rats in the combined intoxication groups were significantly higher than those in the groups with single toxic agent and control group. The results of factorial analysis showed that the joint action induced by TPA, EG and/or DOW were characterized as additive (TPA + EG), synergistic (EG + DOW), synergistic (TPA + DOW) and additive(TPA + EG + DOW) actions. The deduction was identified by morphologic observations.
Yao
Hongwei
H
Third Affiliated Hospital of Nanjing Medical University, Nanjing 211900, China.
Wang
Xinru
X
Xu
Xikun
X
Shi
Aimin
A
D000818:Animals; D004357:Drug Synergism; D019855:Ethylene Glycol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010647:Phenyl Ethers / Q000633:toxicity*; D010795:Phthalic Acids / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010647:Phenyl Ethers; D010795:Phthalic Acids; C011363:terephthalic acid; C032244:dowtherm; D019855:Ethylene Glycol