title: Successful treatment of invasive aspergillosis in two patients with acute myelogenous leukemia.
abstract: Invasive aspergillosis is a severe, devastating fungal infection that is seen in patients with hematologic malignancies and profound neutropenia. Despite aggressive treatment, the outcome is poor without neutrophil recovery. The authors describe two children with acute myelogenous leukemia (AML) with extensive invasive aspergillosis who were successfully treated both for their infection and the underlying malignancy. These patients were treated aggressively for their infections and simultaneously were able to complete treatment of their AML. Currently both patients are alive without evidence of fungal infection or AML. Patients with hematologic malignancies can survive severe, invasive aspergillosis during prolonged periods of neutropenia with a combination of antifungal and growth factor therapies, donor granulocyte infusions, and surgical debridement.
authors.affiliation: Department of Pediatic Hematology/Oncology, Children's natonal Medical Center, Washington, DC 20010, USA.
authors.forename: Melissa S
authors.initials: MS
authors.lastname: Singer
authors.forename: Nita L
authors.initials: NL
authors.lastname: Seibel
authors.forename: Gilbert
authors.initials: G
authors.lastname: Vezina
authors.forename: Sukgi S
authors.initials: SS
authors.lastname: Choi
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Dinndorf
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D000666:Amphotericin B