[The prophylactic effect of BCG polysaccharides nucleic acid on the acute attack of chronic obstructive pulmonary disease].
OBJECTIVE
To investigate the prophylactic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with chronic obstructive pulmonary disease and inquire about the mechanism thereof.


METHODS
Sixty patients with chronic obstructive pulmonary disease were divided into two groups. In the treatment group, 36 patients received BCG-PSN 0.5 mg intramuscular injection, quaque die alterna, for 18 times. All patients revisited the hospital every 2 weeks and were followed up for 6 months. The number and days of patients with acute attack in 3 and 6 months were assessed. In the treatment group, the blood samples were collected before treatment and 3 and 6 months after treatment for the measurement of the blood IgA, IgG, IgM, CD3, CD4 and CD8.


RESULTS
The number and days of patients with acute attack in the treatment group were significantly lower than those in the control group. After the treatment by BCG-PSN, blood CD4 and CD4/CD8 were significantly increased.


CONCLUSIONS
BCG-PSN increases the patient's cellular immunocompetence and thus serves as a good protection against the acute attack of chronic obstructive pulmonary disease.
Cheng
Deyun
D
Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Zheng
Bixia
B
Chen
Wenbin
W
Chen
Zhuyuan
Z
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000737:chemistry*; D009696:Nucleic Acids / Q000627:therapeutic use*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000517:prevention & control* / Q000628:therapy
D009696:Nucleic Acids; D011135:Polysaccharides, Bacterial