title: A retrospective study regarding the treatment of lupoid onychodystrophy in 30 dogs and literature review.
abstract: The treatment records of 30 dogs with lupoid onychodystrophy were evaluated retrospectively. Dogs were treated with fatty acid supplementation (n=18), doxycycline and niacinamide (n=12), tetracycline and niacinamide (n=10), pentoxifylline (n=6), prednisolone (n=5), azathioprine (n=1), clofazimine (n=1), or with combinations thereof. An excellent response was seen in almost half of the patients treated with tetra- or doxycycline in combination with niacinamide. Six of the dogs were maintained successfully on fatty acid supplementation. Spontaneous remissions and recurrences made evaluation of success rates difficult and emphasized the varied and often unclear etiology and natural course of the syndrome.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.
authors.forename: Ralf S
authors.initials: RS
authors.lastname: Mueller
authors.forename: Rodney A W
authors.initials: RA
authors.lastname: Rosychuk
authors.forename: Leonard D
authors.initials: LD
authors.lastname: Jonas
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D002991:Clofazimine / Q000008:administration & dosage / Q000627:therapeutic use; D019587:Dietary Supplements; D004283:Dog Diseases / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D006724:Hoof and Claw; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000627:therapeutic use; D010431:Pentoxifylline / Q000008:administration & dosage / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D014739:Victoria / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015525:Fatty Acids, Omega-3; D007166:Immunosuppressive Agents; D009536:Niacinamide; D011239:Prednisolone; D002991:Clofazimine; D013752:Tetracycline; D001379:Azathioprine; D004318:Doxycycline; D010431:Pentoxifylline