Is ATP-sensitive K+ channel (K+ATP) recruitment a common mechanism for ECG-ST segment depression and elevation?
ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal experimentation designed to test the genesis of ECG-ST segment elevations and depressions in diverse conditions including digitalis effect, acute arterial occlusion, tachycardias, and acute pericarditis. A specific series of animal experiments designed to test this hypothesis is proposed. Clinical implications are discussed.
Hoffman
Irwin
I
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. irwin.hoffman@stvin.org
Saltzman
Beth
B
D000200:Action Potentials; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000473:pathology; D002316:Cardiotonic Agents / Q000494:pharmacology; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D015221:Potassium Channels / Q000378:metabolism*
D002316:Cardiotonic Agents; D015221:Potassium Channels; D000255:Adenosine Triphosphate