title: Association of comorbid posttraumatic stress disorder and major depression with greater risk for suicidal behavior.
abstract: OBJECTIVE
  Posttraumatic stress disorder (PTSD) increases the risk of suicidal behavior; a major depressive episode also increases the risk for suicidal behavior. The authors' goal was to examine the effect of comorbid PTSD and major depressive episode on suicidal behavior.
  
  
  METHODS
  Inpatients with a diagnosis of major depressive episode (N=156) were assessed for PTSD, suicidal behavior, and clinical risk factors for suicidal acts.
  
  
  RESULTS
  Patients with comorbid major depressive episode and PTSD were more likely to have attempted suicide, and women with both disorders were more likely to have attempted suicide than men with both disorders. Cluster B personality disorder and PTSD were independently related to history of suicide attempts.
  
  
  CONCLUSIONS
  The greater rate of suicide attempts among patients with comorbid PTSD and major depressive episode was not due to differences in substance use, childhood abuse, or cluster B personality disorders.
authors.affiliation: New York State Psychiatric Institute, Columbia University, New York, 10032, USA. moquendo@neuron.cpmc.columbia.edu
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oquendo
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Friend
authors.forename: Batsheva
authors.initials: B
authors.lastname: Halberstam
authors.forename: Beth S
authors.initials: BS
authors.lastname: Brodsky
authors.forename: Ainsley K
authors.initials: AK
authors.lastname: Burke
authors.forename: Michael F
authors.initials: MF
authors.lastname: Grunebaum
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Malone
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
mesh_terms: D000374:Aggression / Q000523:psychology; D002648:Child; D002649:Child Abuse / Q000523:psychology / Q000706:statistics & numerical data; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D010554:Personality Disorders / Q000453:epidemiology / Q000523:psychology; D012307:Risk Factors; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology* / Q000523:psychology; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*