Stability of allelic frequencies and distributions of Candida albicans microsatellite loci from U.S. population-based surveillance isolates.
Allelic distributions and frequencies of five Candida albicans microsatellite loci have been determined for strains isolated from the bloodstream and obtained through active population-based surveillance in two U.S. metropolitan areas between 1998 and 2000. These data were compared to data for isolates obtained from two other U.S. regions in 1992 to 1993. In a majority of pairwise combinations between sites, no evidence was seen for shifts in microsatellite allelic frequencies. One to three alleles were highly predominant and correlated with major genotypes. These data both support the concepts of allelic stability and genetic equilibria and suggest that, in the United States, strains of C. albicans isolated from the bloodstream may form a defined, genetically homogeneous population across geographical distance and time.
Lott
Timothy J
TJ
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. tjl1@dcd.gov
Fundyga
Ruth E
RE
Brandt
Mary E
ME
Harrison
Lee H
LH
Sofair
Andre N
AN
Hajjeh
Rana A
RA
Warnock
David W
DW
D002176:Candida albicans / Q000235:genetics*; D004271:DNA, Fungal / Q000032:analysis; D005787:Gene Frequency; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D011159:Population Surveillance; D014481:United States
D004271:DNA, Fungal