Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-gamma and IL-4 expression in psoriatic skin in situ.
Piskin
Gamze
G
Department of Dermatology, Room L3-359, Academic Medical Center, University of Amsterdam, P.O. Box: 22700, The Netherlands. g.piskin@amc.uva.nl
Heydendael
Vera M R
VM
de Rie
Menno A
MA
Bos
Jan D
JD
Teunissen
Marcel B M
MB
D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007371:Interferon-gamma / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D018655:Lymphocyte Count; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000473:pathology
D007166:Immunosuppressive Agents; D015847:Interleukin-4; D007371:Interferon-gamma; D016572:Cyclosporine; D008727:Methotrexate