Multidrug resistance 1 gene expression in Indian patients with gastric carcinoma.
BACKGROUND
Gastric carcinoma is frequently refractory to chemotherapy. The multidrug resistance 1 gene (MDR1) encodes for a protein (p-glycoprotein) that functions as a drug efflux pump and thus contributes to resistance to chemotherapeutic agents.


METHODS
We studied gastric tissues from 28 patients with gastric cancer for MDR1 expression, using immunohistochemistry.


RESULTS
Sixteen (57%) of 28 cases showed MDR1 expression. Sections of normal mucosa away from the tumor showed perinuclear staining for MDR1 in surface epithelial cells, whereas tumor cells showed diffuse cytoplasmic positivity.


CONCLUSIONS
Over one half of gastric carcinoma specimens at our center show MDR1 gene expression.
Ramesh
S
S
Department of Pathology, Dr A L Mudaliar Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113.
Shanthi
P
P
Krishnan
K Baba
KB
Shanthi
A V
AV
Taralakshmi
V V
VV
Subulakshmi
S
S
D000368:Aged; D005260:Female; D015870:Gene Expression; D019450:Genes, MDR / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D007194:India; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000235:genetics*