Synthesis of (+/-)-trans- or cis-(5-aminomethyltetrahydrofuranyl)imidazole by Mitsunobu cyclization: synthetic studies toward novel histamine H3 or H4-ligands.
The (+/-)-trans- or cis-4(5)-(5-aminomethyltetrahydrofuranyl)imidazole [1 and 2] were synthesized by the Mitsunobu cyclization, starting from L-glutamic acid.
Harusawa
Shinya
S
Osaka University of Pharmaceutical Sciences, Tatatsuki, Japan.
Araki
Lisa
L
Imazu
Tomonari
T
Ohishi
Hirofumi
H
Sakamoto
Yasuhiko
Y
Kurihara
Takushi
T
D003500:Cyclization; D017442:Histamine Agonists / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4; D013237:Stereoisomerism
C418607:HRH4 protein, human; D017442:Histamine Agonists; D007093:Imidazoles; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4