Clinicopathologic features of ileocolonic malignant lymphoma: analysis according to colonoscopic classification.
BACKGROUND
The aims of this study were to classify primary ileocolonic lymphomas according to colonoscopic findings and to determine the clinicopathologic relationship according to classes.


METHODS
Thirty-two patients (22 men, 10 women; age range 29 to 75 years) with primary malignant lymphoma of the terminal ileum and/or colorectum were studied. The clinicopathologic features were evaluated according to colonoscopic findings.


RESULTS
Thirty-six lesions in 32 patients were endoscopically classified as follows: fungating (14, 39%), ulcerofungating (11, 31%), infiltrative (5, 14%), ulceroinfiltrative (4, 11%), and ulcerative (2, 6%). Location of the lesions was as follows: terminal ileum, 15 (42%); colorectum, 14 (39%); both regions, 7 (19%). The most common histopathologic types were diffuse large cell (22, 69%) and large cell immunoblastic (5, 16%). There was no relationship between the endoscopic findings and histologic types. In 9 patients (28%), the clinical manifestation was intussusception, and all were found endoscopically to have the fungating type lesion.


CONCLUSIONS
Primary ileocolonic lymphomas can be classified endoscopically into fungating, ulcerative, infiltrative, ulcerofungating, and ulceroinfiltrative types. Among these, fungating and ulcerofungating are the most frequent. Intussusception is a common clinical finding in ileocolonic lymphomas, occurring mainly in patients with the fungating type of lesion.
Myung
Seung-Jae
SJ
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Joo
Kwang Ro
KR
Yang
Suk-Kyun
SK
Jung
Hwoon-Yong
HY
Chang
Hye-Sook
HS
Lee
Hyun Ju
HJ
Hong
Weon-Seon
WS
Kim
Jin-Ho
JH
Min
Young Il
YI
Kim
Hee Cheol
HC
Yu
Chang Sik
CS
Kim
Jin Cheon
JC
Kim
Jung-Sun
JS
D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000145:classification / Q000175:diagnosis*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000145:classification / Q000175:diagnosis*; D007082:Ileum / Q000473:pathology; D008223:Lymphoma / Q000145:classification / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000175:diagnosis*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000145:classification / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged