The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis.
Type B leukemogenic virus (TBLV) is a variant of mouse mammary tumor virus (MMTV) that causes T-cell lymphomas in mice. We have constructed a TBLV-MMTV hybrid, pHYB-TBLV, in which 756 bp of the C3H MMTV long terminal repeat (LTR) was replaced with 438 bp of the TBLV LTR. Intraperitoneal injection of pHYB-TBLV transfectants consistently resulted in T-cell lymphomas in 50% of injected weanling BALB/c mice with an average latency period of 5.7 (+/- 1.5) months. Transfectants of pHYB-TBLV containing a double-frameshift mutation in the truncated superantigen gene (sag) induced T-cell lymphomas with similar incidences, latency periods, and phenotypes, suggesting that cis-acting elements in the TBLV LTR determine disease specificity.
Mustafa
Farah
F
Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, the University of Texas at Austin, Austin, Texas 78712, USA.
Bhadra
Sanchita
S
Johnston
Dennis
D
Lozano
Mary
M
Dudley
Jaquelin P
JP
D000818:Animals; D005260:Female; D006801:Humans; D019169:Jurkat Cells; D016399:Lymphoma, T-Cell / Q000503:physiopathology* / Q000821:virology*; D008297:Male; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D011995:Recombination, Genetic; D012192:Retroviridae Infections / Q000821:virology; D018089:Superantigens / Q000235:genetics* / Q000276:immunology; D020079:Terminal Repeat Sequences / Q000235:genetics; D014412:Tumor Virus Infections / Q000821:virology
D018089:Superantigens