Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone.
The effect of the thiazolidinedione, rosiglitazone (8 mg/d for 7 days), on the production rates of testosterone (T), dihydrotestosterone (DHT), and cortisol (F) was studied in healthy men (n = 10) using the stable isotope dilution technique and mass spectrometry. Treatment with rosiglitazone resulted in a decrease in the production rates of T from, basal, 318 +/- 62 microg/h to 272 +/- 72 microg/h (P <.05). Production rates of DHT fell from, basal, 21 +/- 6 microg/h to 17 +/- 5 microg/h (P <.05). Hence, the ratio calcuated from the production rates of T and DHT was unchanged (basal, 17 +/- 7; rosiglitazone, 17 +/- 3). Production rates of cortisol were unchanged (basal, 577 +/- 136 microg/h; rosiglitazone, 627 +/- 141 microg/h). These results suggest that a clinically relevant dose of at least one thiazolidindione, rosiglitazone, impedes the production of testosterone in man.
Vierhapper
H
H
Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria.
Nowotny
P
P
Waldhäusl
W
W
D000328:Adult; D013196:Dihydrotestosterone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D008297:Male; D011897:Random Allocation; D012016:Reference Values; D000077154:Rosiglitazone; D013256:Steroids / Q000652:urine; D013739:Testosterone / Q000096:biosynthesis*; D013844:Thiazoles / Q000494:pharmacology*; D045162:Thiazolidinediones
D013256:Steroids; D013844:Thiazoles; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D013196:Dihydrotestosterone; D013739:Testosterone; D006854:Hydrocortisone