title: [Antifungal activity of Caryocar brasiliensis (Caryocaraceae) against Cryptococcus neoformans].
abstract: The widespread occurrence of cryptococcosis mainly in immunocompromised patients and the side effects of available drugs which are effective against this mycosis have led investigators to search for new antimycotic agents. Caryocar brasiliensis derived compounds were investigated against Cryptococcus neoformans using the agar dilution method. Based on MIC values, the best results were obtained with a concentration of < 250 g/mL of cuticular waxes of the Caryocar brasiliensis leaf collected during the dry period (170.8mm of precipitation) which inhibited the growth of 91.3% (21/23) Cryptococcus neoformans isolates.
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Xisto Sena
authors.initials: XS
authors.lastname: Passos
authors.forename: Suzana da Costa
authors.initials: Sda C
authors.lastname: Santos
authors.forename: Pedro Henrique
authors.initials: PH
authors.lastname: Ferri
authors.forename: Orionalda de Fátima Lisboa
authors.initials: Ode F
authors.lastname: Fernandes
authors.forename: Thaliana de Freitas
authors.initials: Tde F
authors.lastname: Paula
authors.forename: Ana Cristina Ferreira
authors.initials: AC
authors.lastname: Garcia
authors.forename: Maria do Rosário Rodrigues
authors.initials: Mdo R
authors.lastname: Silva
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D019685:Rosales
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D010938:Plant Oils