Of mouse and man--what is the value of the mouse in predicting gene expression in humans?
The mouse is the most commonly used mammalian species in biomedical research and is widely regarded as a human surrogate species. In this Editorial, Robert Coleman discusses the validity of this assumption and cautions against the unquestioning acceptance of the mouse an experimental model for drug discovery and development.
Coleman
Robert A
RA
D000818:Animals; D035843:Biomedical Research; D005544:Forecasting; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice / Q000235:genetics*; D023421:Models, Animal; D013045:Species Specificity