title: [Subcutaneous "wash-out" in extravasations].
abstract: Extravasations of chemotherapeutic drugs may lead to large soft-tissue losses in the hand and forearm and necessitating surgical excision with secondary flap coverage. Unfortunately, a delayed referral to a hand and plastic surgical unit with an already established soft-tissue defect is most common. Nevertheless, in our unit the method of choice is early emergency subcutaneous "wash-out", which facilitates dilution and reduction of concentration of the extravasation and therefore reliably avoids the development of soft-tissue defects. The aim of this paper is to present the surgical technique.
authors.affiliation: Abteilung für Plastische und Wiederherstellungschirurgie, Klinikum rechts der Isar, Technische Universität München, Munich. R.Giunta@t-online.de
authors.forename: R
authors.initials: R
authors.lastname: Giunta
authors.forename: J
authors.initials: J
authors.lastname: Akpaloo
authors.forename: L
authors.initials: L
authors.lastname: Kovacs
authors.forename: E
authors.initials: E
authors.lastname: Biemer
mesh_terms: D000765:Anesthesia, Conduction; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D002057:Burns, Chemical / Q000601:surgery*; D002199:Capillary Permeability / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004630:Emergencies; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000601:surgery*; D005543:Forearm Injuries / Q000139:chemically induced* / Q000601:surgery; D006230:Hand Injuries / Q000139:chemically induced* / Q000601:surgery; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D006821:Hyaluronoglucosaminidase; D004121:Dimethyl Sulfoxide