title: Gastroesophageal reflux disease.
abstract: Heartburn on 2 or more days a week warrants medical attention, as patients are likely to suffer from gastroesophageal reflux disease (GERD). Chronic GERD can lead to the development of complications including erosive esophagitis, stricture formation, and Barrett's esophagus, which increases the risk of esophageal adenocarcinoma. A trial with a proton pump inhibitor (PPI) is the quickest and most cost-effective way to diagnose GERD, and is at least as sensitive as 24-hour intra-esophageal pH monitoring. As PPIs only bind to actively secreting proton pumps, they should be dosed 30 to 60 minutes before a meal. Despite these recommendations, a recent survey of over 1000 US primary care physicians found that 36% instructed their patients to take a PPI with or after a meal or did not specify the timing of dosing. The patients who will have the best response to surgical therapy for GERD are those who had clearly documented acid reflux with typical symptoms, and who have responded to PPI treatment. Unfortunately, the same survey found that most physicians recommend antireflux surgery for patients in whom medical therapy has failed.
authors.affiliation: Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Colin W
authors.initials: CW
authors.lastname: Howden
authors.forename: William D
authors.initials: WD
authors.lastname: Chey
mesh_terms: D002986:Clinical Trials as Topic; D013505:Digestive System Surgical Procedures; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000628:therapy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D017410:Practice Guidelines as Topic; D040242:Risk Reduction Behavior
chemical_list: D005765:Gastrointestinal Agents