Suppression by Candida albicans beta-glucan of cytokine release from activated human monocytes and from T cells in the presence of monocytes.
The effect of a soluble beta-glucan from Candida albicans (CSBG) on cytokine production by cultured human peripheral blood mononuclear cells (PBMC) was assessed. CSBG induced a slight increase in the spontaneous release of proinflammatory cytokines, such as interleukin (IL)-6, but significantly suppressed endotoxin-induced IL-6 production in cultures of PBMC and monocytes isolated from PBMC. CSBG also suppressed the release of type 1 cytokines, IL-2, and interferon-gamma. These findings suggest that CSBG suppresses monocyte functions directly and thus suppresses T cell function indirectly. CSBG may play a role in the development of candidiasis.
Nakagawa
Yukari
Y
Division of Biological Evaluation, Osaka Branch, National Institute of Health Sciences, Osaka, Japan. yukari@nihs.go.jp
Ohno
Naohito
N
Murai
Toshimi
T
D002176:Candida albicans; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis*; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005936:Glucans / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis / Q000096:biosynthesis; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis; D015850:Interleukin-6 / Q000032:analysis / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D005936:Glucans; D007376:Interleukin-2; D015850:Interleukin-6; D007371:Interferon-gamma