Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors.
Sarcomatoid renal tumors differ morphologically and prognostically from other renal tumors. Using tissue microarray technology, we show that sarcomatoid renal tumors have a distinct protein expression profile for biomarkers Ki67, gelsolin and PTEN, when compared with clear-cell and papillary renal tumors. Our results confirm the previous reports that Ki67 is highly expressed in sarcomatoid tumors. We also show that gelsolin expression differs between the studied tumor types, suggesting different roles for gelsolin in the carcinogenesis of different renal tumor types.
Visapää
Harri
H
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 695 Charles E. Young Drive South, Box 957088, Los Angeles, CA 90095-7088, USA.
Seligson
David
D
Huang
Yunda
Y
Rao
Jian Yu
JY
Belldegrun
Arie
A
Horvath
Steve
S
Palotie
Aarno
A
D002291:Carcinoma, Papillary / Q000235:genetics; D018260:Gelsolin / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D018227:Sarcoma, Clear Cell / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D018260:Gelsolin; D019394:Ki-67 Antigen; D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human