title: Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial.
abstract: The aim of the study is to evaluate the effect of a single treatment with the molecular adsorbents recirculating system (MARS) on systemic hemodynamics and oxygen consumption (VO(2)) in patients with hyperacute liver failure (HALF). In a controlled design, eight patients with HALF were assigned to a 6-hour MARS treatment, and five patients, to a control group that was mechanically cooled to match the MARS group. Systemic hemodynamic variables were determined hourly during the study period. In the MARS group, systemic vascular resistance index increased by 46% from 1,215 +/- 437 to 1,778 +/- 710 dynes x s x cm(-5) x m(-2) (P <.0001), which significantly exceeded a 6% increase in the control group. Mean arterial pressure increased from 69 +/- 5 to 83 +/- 11 mm Hg in the MARS group (P <.0001) and was unchanged in the control group. Cardiac index decreased by 20% from 4.6 +/- 1.8 to 3.7 +/- 1.1 L/min x m(-2) (P =.0007) in the MARS group and by 7% in the control group. Heart rate decreased from 105 +/- 21 to 85 +/- 15 beats/min in the MARS group (P <.0001) and was unchanged in the control group. In the MARS group, oxygen delivery decreased from 621 +/- 198 to 486 +/- 141 mL/min x m(-2) (P <.05), and VO2, from 142 +/- 31 to 112 +/-21 mL/min x m(-2) (P <.05). Arterial lactate and pH levels were unchanged. In conclusion, systemic hemodynamic values tend to normalize, whereas systemic VO(2) decreases during MARS treatment in patients with HALF. These effects cannot be explained by the degree of cooling associated with MARS.
authors.affiliation: Department of Hepatology, Rigshospitalet, University Hospital, Copenhagen, Denmark. lars.schmidt@dadlnet.dk
authors.forename: Lars E
authors.initials: LE
authors.lastname: Schmidt
authors.forename: Lars Peter
authors.initials: LP
authors.lastname: Wang
authors.forename: Bent A
authors.initials: BA
authors.lastname: Hansen
authors.forename: Fin Stolze
authors.initials: FS
authors.lastname: Larsen
mesh_terms: D000082:Acetaminophen / Q000506:poisoning; D000328:Adult; D000427:Alcohol Deterrents / Q000506:poisoning; D018712:Analgesics, Non-Narcotic / Q000506:poisoning; D001794:Blood Pressure; D056486:Chemical and Drug Induced Liver Injury / Q000628:therapy; D004221:Disulfiram / Q000506:poisoning; D005260:Female; D006339:Heart Rate; D006509:Hepatitis B / Q000628:therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure; D016060:Sorption Detoxification; D013696:Temperature; D016896:Treatment Outcome
chemical_list: D000427:Alcohol Deterrents; D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D010100:Oxygen; D004221:Disulfiram