Chiral ligand-controlled asymmetric conjugate addition of lithium amides to enoates.
The external chiral ligand-controlled asymmetric conjugate addition reaction of lithium amides with alpha,beta-unsaturated esters provided beta-amino esters in high yields and high enantioselectivities.
Doi
Hirohisa
H
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Sakai
Takeo
T
Iguchi
Mayu
M
Yamada
Ken-ichi
K
Tomioka
Kiyoshi
K
D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D004952:Esters / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry
D000577:Amides; D000596:Amino Acids; D004952:Esters; D009942:Organometallic Compounds; D008094:Lithium