title: Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.
abstract: The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.
authors.affiliation: Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Buckle
authors.forename: Per
authors.initials: P
authors.lastname: Höllsberg
authors.forename: David A
authors.initials: DA
authors.lastname: Hafler
mesh_terms: D000328:Adult; D000906:Antibodies / Q000494:pharmacology; D017252:CD3 Complex / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D002469:Cell Separation; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D005787:Gene Frequency; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics / Q000276:immunology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values
chemical_list: D000906:Antibodies; D017252:CD3 Complex; D016207:Cytokines; D008233:Lymphotoxin-alpha