The use of lymecycline in the treatment of moderate to severe acne vulgaris: a comparison of the efficacy and safety of two dosing regimens.
We compared the efficacy and safety of lymecycline 300 mg od vs lymecycline 150 mg bid or placebo in the treatment of moderate to severe acne. 271 patients received either oral lymecycline 300 mg od + placebo od, lymecycline 150 mg bid, or placebo bid, for 12 weeks. Reduction in inflammatory lesion counts at week 12 was the primary efficacy variable (global improvement was a primary efficacy parameter vs placebo) and safety was assessed by adverse events. Lymecycline 300 mg od was non-inferior to lymecycline 150 mg bid at all time points and superior to placebo throughout the study. Drug-related adverse events were similar for all treatment groups. Lymecycline 300 mg od is as effective and safe as lymecycline 150 mg bid in the treatment of moderate to severe acne. This new, once daily formulation could potentially contribute towards improved compliance rates with oral tetracyclines.
Dubertret
Louis
L
Hôpital St Louis, 1 Av. Claude Vellefaux, 75475 Paris, France. elisabeth.treillard@sls.ap-hop-paris.fr
Alirezai
Mohsen
M
Rostain
Gilles
G
Lahfa
Morad
M
Forsea
Dan
D
Niculae
Bogdan Dimitrie
BD
Simola
Margit
M
Horvath
Attila
A
Mizzi
Fabienne
F
D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008194:Lymecycline / Q000008:administration & dosage*; D008297:Male
D000900:Anti-Bacterial Agents; D008194:Lymecycline