title: Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes.
abstract: Pure white cell aplasia (PWCA) is a rare disorder of unknown origin, often associated with thymoma, characterized by selective neutropenia or pure agranulocytosis, and absence of granulocyte precursors in the bone marrow, but with normal erythroblasts and megakaryocytes. We report a case of PWCA associated with thymoma. Unusual findings in this case report included simultaneous presence of autoimmune thyroiditis, type 1 diabetes, anti-striated muscle antibodies, and the presence in the peripheral blood of CD8+ T cells that expressed a homogeneous naive phenotype. Neutrophil count became normal on immunosuppressive therapy after thymectomy.
authors.affiliation: 2nd Clinic of Internal Medicine, University Hospital, Geneva, Switzerland.
authors.forename: Zina
authors.initials: Z
authors.lastname: Fumeaux
authors.forename: Photis
authors.initials: P
authors.lastname: Beris
authors.forename: Bettina
authors.initials: B
authors.lastname: Borisch
authors.forename: François P
authors.initials: FP
authors.lastname: Sarasin
authors.forename: Eddy
authors.initials: E
authors.lastname: Roosnek
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dayer
authors.forename: Carlo
authors.initials: C
authors.lastname: Chizzolini
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000150:complications* / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007970:Leukopenia / Q000150:complications / Q000276:immunology / Q000628:therapy; D018482:Muscle, Skeletal / Q000276:immunology; D012074:Remission Induction; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000628:therapy; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000628:therapy
chemical_list: D001323:Autoantibodies