[Nitric oxide synthase in neurons of the vagal nucleus dorsalis and ganglion nodosum and its changes following acetylcholine inhalation in the norm and in experimental bronchial asthma].
The expression NADPH-diaphorase and inducible NO-synthase (NOS) was studied in vagal nucleus dorsalis and ganglion nodosum neurons following acethylcholine inhalation in healthy rats and rats with ovalbumin-induced experimental bronchial asthma (BA). It was found that NOS activity regulation is mediated by cholinoreceptors; functioning of this mechanism is disturbed in hypoxic state. It is shown that both in conditions of physiological norm and in experimental BA, changes in NOS activity are determined by its constitutive, neuronal isoform.
Eliseeva
E V
EV
Department of Histology, Vladivostok State Medical University.
Romanova
N E
NE
Baranov
V F
VF
Motavkin
P A
PA
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000280:Administration, Inhalation; D000818:Animals; D001249:Asthma / Q000201:enzymology* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D009620:Nodose Ganglion / Q000201:enzymology / Q000473:pathology; D009847:Olivary Nucleus / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D014630:Vagus Nerve / Q000201:enzymology* / Q000473:pathology
D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D009252:NADPH Dehydrogenase; D000109:Acetylcholine