[Antifungal activity of Caryocar brasiliensis (Caryocaraceae) against Cryptococcus neoformans].
The widespread occurrence of cryptococcosis mainly in immunocompromised patients and the side effects of available drugs which are effective against this mycosis have led investigators to search for new antimycotic agents. Caryocar brasiliensis derived compounds were investigated against Cryptococcus neoformans using the agar dilution method. Based on MIC values, the best results were obtained with a concentration of < 250 g/mL of cuticular waxes of the Caryocar brasiliensis leaf collected during the dry period (170.8mm of precipitation) which inhibited the growth of 91.3% (21/23) Cryptococcus neoformans isolates.
Passos
Xisto Sena
XS
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Santos
Suzana da Costa
Sda C
Ferri
Pedro Henrique
PH
Fernandes
Orionalda de Fátima Lisboa
Ode F
Paula
Thaliana de Freitas
Tde F
Garcia
Ana Cristina Ferreira
AC
Silva
Maria do Rosário Rodrigues
Mdo R
D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D019685:Rosales
D000935:Antifungal Agents; D010936:Plant Extracts; D010938:Plant Oils