title: The role of long-lived plasma cells in autoimmunity.
abstract: Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.
authors.affiliation: German Rheumatism Research Center, Berlin, Germany. arce@drfz.de
authors.forename: Sergio
authors.initials: S
authors.lastname: Arce
authors.forename: Giuliana
authors.initials: G
authors.lastname: Cassese
authors.forename: Anja
authors.initials: A
authors.lastname: Hauser
authors.forename: Thomas
authors.initials: T
authors.lastname: Dörner
authors.forename: Marcus
authors.initials: M
authors.lastname: Odendahl
authors.forename: Rudi
authors.initials: R
authors.lastname: Manz
authors.forename: Andrea
authors.initials: A
authors.lastname: Radbruch
authors.forename: Falk
authors.initials: F
authors.lastname: Hiepe
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity; D002470:Cell Survival; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D010950:Plasma Cells / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016207:Cytokines