title: Salivary secretion of immunoglobulin A by submandibular glands in response to autonomimetic infusions in anaesthetised rats.
abstract: Salivary secretion of immunoglobulin A (lgA) by submandibular glands is increased by stimuli from autonomic nerves. Since it is unclear which specific autonomic receptors transduce such stimuli, we have infused autonomimetics intravenously and compared secretion of fluid, IgA and stored proteins (peroxidase and total protein) with secretory responses during electrical stimulation of the parasympathetic nerve supply in anaesthetized rats. The greatest secretion of IgA was evoked by the alpha-adrenoceptor agonist phenylephrine and this was reduced by the beta-adrenoceptor blocking drug propranolol. The secretion of fluid or proteins but not IgA was increased with frequency of nerve stimulation and dose of methacholine (cholinergic), isoprenaline (beta-adrenergic) or phenylephrine (alpha-adrenergic).
authors.affiliation: Salivary Research Group, Unit, Guy's, King's and St. Thomas' School of Dentistry, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK. gordon.proctor@kcl.ac.uk
authors.forename: G B
authors.initials: GB
authors.lastname: Proctor
authors.forename: J R
authors.initials: JR
authors.lastname: Garrett
authors.forename: G H
authors.initials: GH
authors.lastname: Carpenter
authors.forename: L E
authors.initials: LE
authors.lastname: Ebersole
mesh_terms: D000322:Adrenergic Agonists / Q000494:pharmacology*; D018674:Adrenergic Antagonists / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D017776:Autonomic Pathways / Q000187:drug effects / Q000502:physiology*; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D017777:Parasympathetic Fibers, Postganglionic / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D013363:Submandibular Gland / Q000276:immunology / Q000294:innervation* / Q000378:metabolism*; D017779:Sympathetic Fibers, Postganglionic / Q000187:drug effects / Q000502:physiology
chemical_list: D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018680:Cholinergic Antagonists; D007070:Immunoglobulin A; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta