Synergistic effect of ayurvedic pearl preparation on enhancing effectiveness of antibiotics.
Studies were carried out with ayurvedic preparations derived from pearl, which include preparations bhasma and pishti. The synergistic effect to reduce the dose of antibiotic was tested against E. coli the test bacterium with ampicillin antibiotic by bore well and disks diffusion methods. It was observed that pearl preparations do not show any antibacterial activity but when used at 200 microg/ml concentration with antibiotics, then even at sub-lethal dose, the antibiotic has effectively shown the results with reduced contact time. The protocol was also tested with the other bacteria like, Pseudomonas aeruginosa. Vibrio cholarae, Salmonella typhi, and Staphylococcus aureus and has shown similar results. The pearl bhasma synergistic effect was also tested with other antibiotics such as erythromycin, kanamycin, and ampicillin.
Kulkarni
Manisha
M
National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440 020, India.
Deopujari
J Y
JY
Purohit
H J
HJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008515:Medicine, Ayurvedic; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012485:Salmonella typhi / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014734:Vibrio cholerae / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents