[Pharmacological analysis of the pathogenesis of acute poisoning with the synthetic pyrethroid cypermethrin using the hydrobiont Daphnia magna Straus].
The results of pharmacological analysis are presented which provide information on the pathogenesis of acute cypermethrin poisoning that involves disturbances in various systems of the organism. These include changes in the system of excitatory amino acids (EAAs) and violation of the free radical generation processes, Na + channel functioning, cholinergic transmission, etc. The screening of drugs belonging to various pharmacological groups influencing the toxicity of pyrethroids (EAA receptor antagonists, antioxidants, Na + channel blockers, M-cholinoreceptor blockers) revealed promising agents for the treatment of cypermethrin poisoning.
Podosinovikova
N P
NP
Biochemistry and Toxicology Laboratories, Institute of Toxicology, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
Solov'eva
N E
NE
Mukovskiĭ
L A
LA
Petrov
V V
VV
Matveev
B B
BB
Dolgo-Saburov
V B
VB
D000818:Animals; D003621:Daphnia / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D007306:Insecticides / Q000506:poisoning*; D011041:Poisoning / Q000209:etiology / Q000517:prevention & control; D011722:Pyrethrins / Q000506:poisoning*
D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin