title: Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma.
abstract: We report the first case of a polymorphous low-grade adenocarcinoma (PLGA) occurring in the vulva and vagina of a 32-year-old woman. This tumor consisted of cellular lobules with distinct cribriform, papillary, and cystic patterns. Owing to its location and its distinct cribriform pattern, this lesion was initially diagnosed as an unusual variant of adenoid cystic carcinoma (ACC). However, this diagnosis was revised to PLGA when it was recognized that the cribriform, papillary and cystic patterns and their concomitant occurrence in the same lesion are characteristic of PLGA. PLGA should be added to the differential diagnosis of vulvar and vaginal neoplasia.
authors.affiliation: Department of Pathology, Cook County Hospital, Chicago, IL 60612, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Young
authors.forename: Marino
authors.initials: M
authors.lastname: Leon
authors.forename: Aleksander
authors.initials: A
authors.lastname: Talerman
authors.forename: Maria
authors.initials: M
authors.lastname: Teresi
authors.forename: Rajysree
authors.initials: R
authors.lastname: Emmadi
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D022083:Cytoplasmic Structures / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor