title: Recent trends in the use of radical prostatectomy in England: the epidemiology of diffusion.
abstract: OBJECTIVE
  To describe recent trends in the use of radical prostatectomy (RP) in England, as there is currently no consensus on the most effective treatment for localized prostate cancer, although RP is the treatment of choice among urological surgeons for men aged < 70 years.
  
  
  METHODS
  Routine data were assessed to establish the number of RPs performed in England in 1991-99. Age-standardized operation rates were compared by region and socio-economic group, and the geographical spread of use mapped.
  
  
  RESULTS
  The number of RPs performed annually increased nearly 20-fold between 1991 and 1999. Rates of surgery were greatest in the London National Health Service (NHS) regions and lowest in the Trent region. Outside London, the risk of surgery in a NHS hospital was significantly greater for men living in the least deprived areas; in London this trend was reversed.
  
  
  CONCLUSIONS
  Rapid increases in the use of RP showed marked regional variations, most likely related to access to prostate-specific antigen testing and the location of surgeons able to carry out radical surgery. By 1999, a third of procedures were still being undertaken in 'low-volume' hospitals, with implications for the quality of care and outcomes. Crucially, these developments occurred in the absence of robust information about the effectiveness of RP. Recent funding of a randomized trial of treatment options in this area is welcome, but wider questions remain about the timing of the evaluation of surgical technologies.
authors.affiliation: Department of Health Sciences, University of York, York, UK. so7@york.ac.uk
authors.forename: S E
authors.initials: SE
authors.lastname: Oliver
authors.forename: J L
authors.initials: JL
authors.lastname: Donovan
authors.forename: T J
authors.initials: TJ
authors.lastname: Peters
authors.forename: S
authors.initials: S
authors.lastname: Frankel
authors.forename: F C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: D E
authors.initials: DE
authors.lastname: Neal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004739:England / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000601:surgery*; D012111:Residence Characteristics; D012307:Risk Factors