title: Cutaneous infection due to Scedosporium apiospermum in an immunosuppressed patient.
abstract: Scedosporium apiospermum, the anamorphic form of Pseudallescheria boydii, is a filamentous fungus with low inherent virulence. Increasing numbers of cases of this infection have been reported probably related to the rising number of immunosuppressed persons. Apart from mycetoma, cutaneous and subcutaneous infection is rarely encountered in clinical practice. We describe a case of cutaneous infection caused by Scedosporium apiospermum in a subject with rheumatoid arthritis and diabetes mellitus who was submitted to long-term therapy with cyclosporin and corticosteroids. Histopathologic examination of a skin biopsy showed a granulomatous infiltrate with hyaline septate hyphae. Culture of two skin biopsies taken at two different observations of the woman, 3 weeks apart, allowed isolation of Scedosporium apiospermum. Therapy with itraconazole, 400 mg/day, for 3 months was effective in curing the infection.
authors.affiliation: Department of Dermatology, Curry Cabral Hospital, Rua da Beneficiencia, no 8, 1069-166 Lisbon, Portugal.
authors.forename: M A
authors.initials: MA
authors.lastname: Chaveiro
authors.forename: R
authors.initials: R
authors.lastname: Vieira
authors.forename: J
authors.initials: J
authors.lastname: Cardoso
authors.forename: A
authors.initials: A
authors.lastname: Afonso
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000276:immunology; D016572:Cyclosporine / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017964:Itraconazole / Q000627:therapeutic use; D008875:Middle Aged; D008271:Mycetoma / Q000188:drug therapy / Q000276:immunology*; D021681:Scedosporium; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D017964:Itraconazole; D016572:Cyclosporine