title: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.
abstract: To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency.
authors.affiliation: Department of Molecular BioSciences (Biochemistry) and the Centre for Molecular Genetics of Development, University of Adelaide, South Australia 5005, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Lando
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Gorman
authors.forename: Murray L
authors.initials: ML
authors.lastname: Whitelaw
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Peet
mesh_terms: D001216:Asparagine / Q000378:metabolism*; D006900:Hydroxylation; D000860:Hypoxia / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011392:Proline / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors; D001216:Asparagine; D011392:Proline; D010100:Oxygen