Antifungal diterpenes from Hypoestes serpens (Acanthaceae).
Two new diterpenes, fusicoserpenol A and dolabeserpenoic acid A, with antifungal activity, were isolated from leaves of Hypoestes serpens (Acanthaceae). Their structures were elucidated by means of spectrometric methods including 1D and 2D NMR experiments and MS analysis. X-ray crystallographic analysis confirmed the structure of fusicoserpenol A and established the relative configuration.
Rasoamiaranjanahary
Lalao
L
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
Marston
Andrew
A
Guilet
David
D
Schenk
Kurt
K
Randimbivololona
Fanantenanirainy
F
Hostettmann
Kurt
K
D027901:Acanthaceae / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D002963:Cladosporium / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
D000935:Antifungal Agents; D004224:Diterpenes; C473302:dolabeserpenoic acid A; C473303:fusicoserpenol A