Determination of diclofenac in pharmaceutical preparations using a novel PVC membrane sensor.
A novel potentiometric PVC membrane sensor for determination of diclofenac in pharmaceutical preparations has been developed. The sensor is based on the use of the 2,4,6-tri(2-pyridyl)-s-triazine iron(II) diclofenac complex [diclofenac-TPTZ-Fe(II)] as an electroactive material in a plasticized PVC membrane matrix. The sensor exhibits fast, stable and near Nernstian response for diclofenac over the concentration range 10(-2)-10(-6) M and pH 5.5-9.5. Application to quality control analysis of diclofenac in various dosage forms shows an average recovery of 99% with a mean standard deviation of 0.2%. No significant interferences are caused by inorganic and organic anions and various drug excipients and diluents.
Hassan
S S M
SS
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt. saadsmhassan@yahoo.com
Mahmoud
W H
WH
Elmosallamy
M A F
MA
Almarzooqi
M H
MH
D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002138:Calibration; D004008:Diclofenac / Q000032:analysis*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D011143:Polyvinyl Chloride; D015203:Reproducibility of Results; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D013607:Tablets; D004008:Diclofenac; D011143:Polyvinyl Chloride