Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC.
Salmonella Typhimurium DT12, isolated from a 35-day-old infant with diarrhea, was highly resistant to ampicillin, tetracycline, chloramphenicol, streptomycin, gentamycin, sulfamethoxazole/trimethoprim, nalidixic acid, and fluoroquinolones. The patient responded to antibiotic therapy with fosfomycin. Multidrug-resistance may become prevalent in Salmonella infections in Japan, as shown in this first case of a patient infected with fluoroquinolone-resistant Salmonella.
Nakaya
Hideo
H
Kansai Medical University Kohri Hospital, Osaka, Japan. nakaya@kouri.kmu.ac.jp
Yasuhara
Akihiro
A
Yoshimura
Ken
K
Oshihoi
Yukio
Y
Izumiya
Hidemasa
H
Watanabe
Haruo
H
D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D003968:Diarrhea, Infantile / Q000188:drug therapy / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones; D005578:Fosfomycin / Q000008:administration & dosage / Q000494:pharmacology; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D012478:Salmonella Food Poisoning / Q000473:pathology; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D005578:Fosfomycin; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase