[99mTc] liposomes for localizing experimental colitis in a rabbit model.
[(99m)Tc] liposomes (TL) and [(111)In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [(99m)Tc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [(111)In] WBCs. The study demonstrates the usefulness of [(99m)Tc] liposomes for imaging inflammatory bowel diseases.
Awasthi
Vibhudutta
V
Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, Texas 78229-3900, USA. awasthi@uthscsa.edu
Goins
Beth
B
McManus
Linda
L
Klipper
Robert
R
Phillipsa
William T
WT
D000818:Animals; D003092:Colitis / Q000097:blood / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004137:Dinitrochlorobenzene; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008081:Liposomes / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D011237:Predictive Value of Tests; D011817:Rabbits; D013667:Technetium / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods; D014915:Whole-Body Counting
D004137:Dinitrochlorobenzene; D008081:Liposomes; D013667:Technetium