Olfactory ensheathing glia transplantation: a therapy to promote repair in the mammalian central nervous system.
A therapy to treat injuries to the central nervous system (CNS) is, to date, a major clinical challenge. The devastating functional consequences they cause in human patients have encouraged many scientists to search, in animal models, for a repair strategy that could, in the future, be applied to humans. However, although several experimental approaches have obtained some degree of success, very few have been translated into clinical trials. Traumatic and demyelinating lesions of the spinal cord have attracted several groups with the same aim: to find a way to promote axonal regeneration, remyelination, and functional recovery, by using a simple, safe, effective, and viable procedure. During the past decade, olfactory ensheathing glia (OEG) transplantation has emerged as a very promising experimental therapy to promote repair of spinal cords, after different types of injuries. Transplants of these cells promoted axonal regeneration and functional recovery after partial and complete spinal cord lesions. Moreover, olfactory ensheathing glia were able to form myelin sheaths around demyelinated axons. In this article, we review these recent advances and discuss to what extent olfactory ensheathing glia transplantation might have a future as a therapy for different spinal cord affections in humans.
Santos-Benito
Fernando F
FF
Laboratory of Neural Regeneration, Institute of Biomedicine, Valencia, Spain.
Ramón-Cueto
Almudena
A
D000818:Animals; D001369:Axons / Q000502:physiology*; D003711:Demyelinating Diseases / Q000628:therapy*; D006801:Humans; D009186:Myelin Sheath / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000637:transplantation*; D009832:Olfactory Nerve / Q000033:anatomy & histology; D051381:Rats; D013119:Spinal Cord Injuries / Q000628:therapy*