Carbazole as fluorescence carrier for preparation of doxycycline sensor.
Carbazole is a promising pharmaceutical species. A novel optical sensor for determining doxycycline based on the fluorescence quenching of N-allylcarbazole immobilized on an quartz glass plate surface by covalent bonding has been described. The sensor shows satisfactory virtues in reversibility, repeatability, selectivity and sufficient lifetime resulting from its excellent optode membrane. Its response time is less than 60 s. The determination range and detection limit of the sensor are 6.0 x 10(-7)-2.0 x 10(-3) M and 2.0 x 10(-7) M, respectively. The lifetime of each sensor is at least three to four months. The sensor can be used for direct determination of doxycycline in pharmaceutical preparations and urine samples.
Chen
Li-Xin
LX
State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P R. China.
Niu
Cheng-Gang
CG
Zeng
Guang-Ming
GM
Huang
Guo-He
GH
Shen
Guo-Li
GL
Yu
Ru-Qin
RQ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000652:urine; D002227:Carbazoles / Q000737:chemistry*; D004318:Doxycycline / Q000032:analysis* / Q000652:urine*; D005453:Fluorescence; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis; D011791:Quartz; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
D000900:Anti-Bacterial Agents; D002227:Carbazoles; D004364:Pharmaceutical Preparations; C041514:carbazole; D011791:Quartz; D004318:Doxycycline