title: [Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis].
abstract: Fifteen children with atopic dermatitis who had Bifidobacterium-deficient microflora were selected for this study. Eight subjects in the bifidobacteria-administered group were given oral administration of lyophilized bifidobacteria (Bifidobacterium breve M-16V strain). The changes in fecal microflora and clinical symptoms were compared with the control group. In the bifidobacteria-administered group, the proportion of Bifidobacterium in the fecal microflora was increased (P=0.0173) and the proportion of aerobic bacteria was decreased (P=0.0499) after 1 month of administration. Furthermore, significant improvement of allergic symptoms (P=0.0176 in cutaneous symptom score, P=0.0117 in total allergic score) was also observed in the bifidobacteria-administered group. The tendency of allergic symptom improvement in the bifidobacteria-administered group was remarkable compared with the control group; however there was no correlation between changes in fecal microflora and allergic symptoms.
authors.affiliation: Department of Pediatrics, Kansai Medical University Kouri Hospital. hattori1127@ybb.ne.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hattori
authors.forename: Akemi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Misa
authors.initials: M
authors.lastname: Sasai
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Taniuchi
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Kojima
authors.forename: Yohnosuke
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Namba
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yaeshima
mesh_terms: D001644:Bifidobacterium; D003876:Dermatitis, Atopic / Q000382:microbiology* / Q000503:physiopathology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male