Identification of a new HLA-B*40 variant, B*4035.
In this report, the novel allele B*40351 is presented. The allele was identified in a Caucasian individual by sequence-based typing. B*4035 is identical to B*4002 in exon 2, but differs in exon 3 at position 463, where it has an A in stead of a C. This results in an amino acid change from arginine to serine at codon 131 of the mature protein. The haplotype carrying the B*4035 was A3 B*4035 Cw2 DR11 DQ3.
Voorter
C E M
CE
Tissue Typing Laboratory, University Hospital Maastricht, the Netherlands.
Hepkema
B G
BG
Lems
S P M
SP
van den Berg-Loonen
E M
EM
D000483:Alleles; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D044465:White People / Q000235:genetics
D015235:HLA-B Antigens