Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women.
BACKGROUND
The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women.


METHODS
Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction.


RESULTS
Women with II genotype showed a higher intact parathyroid hormone (76 +/- 33 v 55 +/- 27 pg/mL and 52 +/- 26 pg/mL, P =.034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 +/- 0.08 v 1.051 +/- 0.16 pg/mL and 1.053 +/- 0.16 pg/mL).


CONCLUSIONS
The ACE polymorphism could be one of the factors causing bone mass variations.
Pérez-Castrillón
José Luis
JL
Departamento Medicina Interna, Hospital Universitario Río Hortega, Facultad de Medicina, Valladolid, Spain. castrv@terra.es
Justo
Isabel
I
Silva
Jesús
J
Sanz
Alberto
A
Martín-Escudero
Juan Carlos
JC
Igea
Rosa
R
Escudero
Pilar
P
Pueyo
Carol
C
Diaz
Cristina
C
Hernández
Gonzalo
G
Dueñas
Antonio
A
D000328:Adult; D015519:Bone Density / Q000235:genetics*; D002118:Calcium / Q000097:blood / Q000652:urine; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause
D007703:Peptidyl-Dipeptidase A; D002118:Calcium