Membrane fusion.
Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together to destabilize the lipid/water interface and to initiate mixing of the lipids. A single fusion protein may do everything or assemblies of protein complexes may be required for intracellular fusion reactions to guarantee rigorous regulation in space and time. Cellular fusion machines are adapted to fit the needs of different reactions but operate by similar principles in order to achieve merging of the bilayers.
Jahn
Reinhard
R
Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. rjahn@gwdg.de
Lang
Thorsten
T
Südhof
Thomas C
TC
D020816:Amino Acid Motifs; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002135:Calcium-Binding Proteins; D002462:Cell Membrane / Q000378:metabolism; D005089:Exocytosis; D008051:Lipid Bilayers; D008561:Membrane Fusion; D008562:Membrane Glycoproteins / Q000378:metabolism; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D050857:Synaptotagmins
D002135:Calcium-Binding Proteins; D008051:Lipid Bilayers; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D050857:Synaptotagmins