title: [Determination of VMA/Cr and HVA/Cr in random urine collection for the diagnosis of neuroblastoma]
abstract: OBJECTIVE: To evaluate the VMA/Cr and HVA/Cr of random urine in the diagnosis of neuroblastoma. METHODS: VMA/Cr and HVA/Cr were examined in 50 normal children and 11 cases of neuroblastoma (NB) aged 1 approximate, equals 5 years. The concentration of 4-hydroxy-3-methoxy-mandelic acid (VMA) and homovanillic acid (HVA) in random urine collection were analyzed by high-performance liquid chromatography and creatinine (Cr) analyzed by auto-biochemical analyzer. RESULTS: The normal range of VMA/Cr and HVA/Cr were <14.9 mmol/mol and <23.8 mmol/mol, respectively. The positive rate of VMA/Cr and HVA/Cr in NB patients was 90.9%. CONCLUSION: Determination of VMA/Cr and HVA/Cr in random urine collection can be used for NB diagnosis.
authors.affiliation: The Affiliated Children's Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China.
authors.forename: Min-Ju
authors.initials: MJ
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Da
authors.initials: D
authors.lastname: Yu