title: [A quantitatively pathological study on malignant ameloblastomas].
abstract: OBJECTIVE
  The purpose of this study was to investigate the role of nuclear morphometric parameters, DNA content and Ag-NOR count in the differentiating malignant and benign ameloblastomas.
  
  
  METHODS
  Totally 17 cases of malignant ameloblastomas were examined by using HE, AgNOR and DNA stain methods. Morphometric parameters of cell nuclei, DNA content and AgNOR count were quantitatively studied by using an image analysis system.
  
  
  RESULTS
  Seven parameters (area, perimeter, equal diameter, minor diameter, mean diameter, round index, axis ratio) out of ten shape factors were significantly different between malignant and benign ameloblastoma (P < 0.01). AgNOR count and DNA index in malignant ameloblastoma were significantly higher than those in benign ameloblastoma (P < 0.01). Logistic regression equation was established, according to nuclear morphormetric parameters and DNA index.
  
  
  CONCLUSIONS
  Quantitative analysis of DAN content, nuclear morphmetric parameters and AgNOR count may be helpful in differentiating malignant and benign ameloblastomas.
authors.affiliation: College of Stomatology, Wuhan University.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Liu
authors.forename: Shuozhi
authors.initials: S
authors.lastname: Wang
authors.forename: Xinming
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000473:pathology*; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000648:ultrastructure; D009808:Odontogenic Tumors / Q000473:pathology*; D016622:Silver Staining
chemical_list: D004273:DNA, Neoplasm