Apoptosis and lung cancer: a review.
It is important to understand the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death. Defects in apoptosis are implicated in both tumorigenesis and drug resistance, and these defects are cause of chemotherapy failures. These studies should explain the relationship between cancer genetics and treatment sensitivity, and should enable a more rational approach to anticancer drug design and therapy. Lung cancer is a major cause of cancer deaths throughout the world. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) represent the two major categories of lung cancer that differ in their sensitivity to undergo apoptosis. The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed.
Shivapurkar
Narayan
N
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA. adi.gazdar@UTSouthwestern.edu
Reddy
Jyotsna
J
Chaudhary
Preet M
PM
Gazdar
Adi F
AF
D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000503:physiopathology*; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000503:physiopathology*; D003598:Cytoskeletal Proteins; D064550:Death-Associated Protein Kinases; D019008:Drug Resistance, Neoplasm; D019254:Genes, bcl-2 / Q000235:genetics / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D008928:Mitochondria / Q000201:enzymology / Q000502:physiology; D009154:Mutation; D011230:Precancerous Conditions / Q000201:enzymology / Q000503:physiopathology*; D011506:Proteins / Q000235:genetics / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins; C402202:PYCARD protein, human; D011506:Proteins; D016159:Tumor Suppressor Protein p53; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases