title: Investigation of fine-motor disturbances in Wilson's disease.
abstract: Patients suffering from Wilson's disease (WD) can be divided into two main subgroups: neurologic and nonneurologic WD. We measured passive and active fine-motor abilities of 37 WD patients and 24 randomly selected volunteers. The measurement was based on a standardized test set in a defined environment for detection of disturbed finemotor control. The set contains 5 tests comprising rest tremor, postural tremor, target tapping, forefinger tapping and spiral painting, reflecting different aspects of movement disorders. The tests showed significant differences between neurologic WD and volunteers, especially for tasks defining active control. In neurologic WD we found no differences between subgroups whereas for non-neurologic WD we often detected slight movement disorders. The detected movement disorders cam be interpreted as persistent disorders after long-term therapy.
authors.affiliation: Neurology Clinic, Univerity of Leipzig, Leipzig, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hermann
authors.forename: T
authors.initials: T
authors.lastname: Villmann
authors.forename: F
authors.initials: F
authors.lastname: Grahmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Kühn
authors.forename: A
authors.initials: A
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006527:Hepatolenticular Degeneration / Q000145:classification* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills; D009460:Neurologic Examination; D014202:Tremor