An unusual case of palmoplantar keratoderma.
A 55-year-old woman with palmoplantar keratoderma presented an associated hyperhidrosis with distinct odour and maceration. She had had the lesions for about 20 years and this seemed to be an isolated case in her family. This case appeared very unusual because there were no signs of acanthokeratolysis in the biopsies. Two months of treatment with acitretin (Neotigason; 25 mg daily), produced a spectacular result: clearance of all the lesions on both hands and a strong diminution of the lesions on the soles. The Unna-Thost variant of palmoplantar keratoderma usually appears in the first few months of life, and it rarely appears in the third decade. The condition is inherited as an autosomal dominant with high penetrance and expressivity. Our subject appeared to be an exception to these two facts.
Devos
S A
SA
Department of Dermatology, Centre Hospitalier F. Rabelais, Site César De Paepe, Brussels, Belgium. DrDevos.S@pandora.be
Delescluse
J
J
D017255:Acitretin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications; D015776:Keratoderma, Palmoplantar, Diffuse / Q000188:drug therapy / Q000235:genetics; D007641:Keratolytic Agents / Q000627:therapeutic use; D008875:Middle Aged
D007641:Keratolytic Agents; D017255:Acitretin