Multiple myeloma with monosomy 13 developed in trisomy 13 acute myelocytic leukemia: numerical chromosome abnormality during chromosomal segregation process.
We report here an acute myelocytic leukemia (AML-M2) patient with trisomy 13 as the sole cytogenetic anomaly, who had relapse of AML with a normal karyotype and developed multiple myeloma. Fluorescence in situ hybridization analysis using the RB gene probe revealed the plasma cells of multiple myeloma (MM) to have monosomy 13 anomaly, whereas relapsed blast cells of AML carried disomy of chromosome 13. To our knowledge, this is the first case showing clonal evolution of trisomy 13 AML and monosomy 13 MM, which might be derived from the leukemic clone at relapse.
Sashida
Goro
G
First Department of Internal Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.
Ito
Yoshikazu
Y
Nakajima
Akihiro
A
Kawakubo
Ken
K
Kuriyama
Yuzuru
Y
Yagasaki
Fumiharu
F
Bessho
Masami
M
Ohyashiki
Kazuma
K
D002869:Chromosome Aberrations; D020090:Chromosome Segregation; D002882:Chromosomes, Human, Pair 13; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*; D009101:Multiple Myeloma / Q000235:genetics*; D014314:Trisomy / Q000235:genetics*