title: Preparation of griseofulvin nanoparticles from water-dilutable microemulsions.
abstract: Nanoparticles of griseofulvin, a model drug with poor solubility and low bioavailability, were prepared from water dilutable microemulsions by the solvent diffusion technique. Solvent-in-water microemulsion formulations containing water, butyl lactate, lecithin, taurodeoxycholate sodium salt (TDC) or dipotassium glycyrrhizinate (KG), 1,2-propanediol or ethanol were used. The formation of macroscopically homogeneous, stable, fluid, optically transparent, isotropic solutions (microemulsions) was investigated by constructing pseudo-ternary phase diagrams. In the presence of TDC or KG, microemulsion systems that remained transparent on water dilution could be obtained. The displacement of butyl lactate, with an excess of water, from the internal phase of the microemulsions containing the drug into the external phase, lead to successful fabrication of drug nanosuspensions. Nanoparticle size was dependent on microemulsion composition: using KG, griseofulvin nanoparticles below 100 nm with low polydispersity and an increased dissolution rate were obtained.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, via P Giuria 9, Torino 10125, Italy. michele.trotta@unito.it
authors.forename: Michele
authors.initials: M
authors.lastname: Trotta
authors.forename: Marina
authors.initials: M
authors.lastname: Gallarate
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Carlotti
authors.forename: Silvia
authors.initials: S
authors.lastname: Morel
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D004655:Emulsions; D006118:Griseofulvin / Q000008:administration & dosage / Q000737:chemistry*; D008823:Micelles; D036103:Nanotechnology; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013501:Surface-Active Agents / Q000737:chemistry; D013535:Suspensions; D013678:Technology, Pharmaceutical
chemical_list: D000935:Antifungal Agents; D004655:Emulsions; D008823:Micelles; D010713:Phosphatidylcholines; D012997:Solvents; D013501:Surface-Active Agents; D013535:Suspensions; D006118:Griseofulvin