title: Albumin-binding MR blood pool agents as MRI contrast agents in an intracranial mouse glioma model.
abstract: Intravenous MRI contrast agents are commonly used to improve the detection of intracranial tumors and other central nervous system (CNS) lesions for diagnosis and treatment planning. Two small-molecule, albumin-binding blood pool contrast agents (MP-2269 and MS-325) of potential clinical significance were evaluated at 1.5 Tesla in a mouse glioma model and compared with an extracellular contrast agent (OptiMARK). Tumor image contrast was significantly enhanced and long-lived following administration of 30 micromole/kg of the blood pool agents: specifically, contrast enhancement peaked slowly at 25-30 min following administration, remained constant for >3 hr, and returned to baseline within 20 hr. Comparable but "transient" enhancement was achieved using 100 micromole/kg OptiMARK: specifically, contrast enhancement peaked rapidly at 2-5 min following administration and then declined over 40 min. The blood pool contrast agents demonstrated an approximately threefold increased dose-effectiveness and a lengthened window of tumor contrast enhancement in comparison to commonly available extracellular contrast agents. This demonstrates the potential of alternative contrast-enhanced (CE) MRI examination protocols for tumor detection.
authors.affiliation: Imaging Division, Mallinckrodt, Inc., St. Louis, Missouri 63110, USA.
authors.forename: Kofi
authors.initials: K
authors.lastname: Adzamli
authors.forename: Dmitriy A
authors.initials: DA
authors.lastname: Yablonskiy
authors.forename: Michael R
authors.initials: MR
authors.lastname: Chicoine
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Won
authors.forename: Karen P
authors.initials: KP
authors.lastname: Galen
authors.forename: Michael C
authors.initials: MC
authors.lastname: Zahner
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Woolsey
authors.forename: Joseph J H
authors.initials: JJ
authors.lastname: Ackerman
mesh_terms: D000418:Albumins; D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis*; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D009942:Organometallic Compounds
chemical_list: D000418:Albumins; D003287:Contrast Media; D009942:Organometallic Compounds; C058946:albumin-(gadolinium-DTPA); D019786:Gadolinium DTPA; C112666:gadoversetamide