title: Five-year results of trabeculectomy with mitomycin C.
abstract: BACKGROUND
  The long-term efficacy and safety of primary trabeculectomy with mitomycin C were retrospectively studied.
  
  
  METHODS
  Sixty eyes of 60 patients with severe glaucoma, 25 female and 35 male, with a mean age of 72.5 years who underwent primary trabeculectomy with mitomycin C between 1993 and 1995 were included. Glaucoma subtypes consisted of 42 patients with primary open-angle glaucoma, 10 patients with normal-pressure glaucoma, 2 patients with chronic narrow-angle glaucoma, 5 patients with pigment dispersion syndrome and 1 patient with pseudoexfoliation syndrome. During surgery, mitomycin C 0.2 mg/ml was applied under the scleral flap for 3 min.
  
  
  RESULTS
  Mean intraocular pressure (IOP) decreased from 22.3+/-9.3 preoperatively to 12.6+/-3.5 mmHg postoperatively. With success defined as an IOP level of 15 mmHg or less, a success rate of 83.3% was obtained in the 1st year, dropping to 60% in the 6th year following trabeculectomy. Visual fields remained stable in 73.3% of cases during the follow-up period. LogMAR visual acuity increased from 0.2 to 0.4. Four eyes underwent cataract surgery prior to trabeculectomy. Thirteen eyes underwent cataract surgery during the follow-up period. Long-term complications were relatively mild and consisted of two cases of blebitis. Bleb reconstruction was performed in five eyes with overfiltration or bleb-related complaints.
  
  
  CONCLUSIONS
  The present findings indicate that the additional use of mitomycin C may be justified in trabeculectomies in patients with severe glaucoma.
authors.affiliation: University Eye Clinic, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. hbec@soog.azm.nl
authors.forename: Henny J M
authors.initials: HJ
authors.lastname: Beckers
authors.forename: Katja C
authors.initials: KC
authors.lastname: Kinders
authors.forename: Carroll A B
authors.initials: CA
authors.lastname: Webers
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin