Quantitation of film coating on Zantac 75 mg tablets and Epivir HBV 100 mg tablets by ICP-AES.
OBJECTIVE
To present a selective analytical Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) method developed and validated for the quantitation of tablet film coatings containing titanium.


METHODS
Tablet samples were decomposed by either digestion or dry ashing. The amount of film tablet coating was calculated based on titanium content of the sample.


RESULTS
The reported ICP-AES method was accurate, precise, sensitive and linear for determination of titanium concentrations from 2.9 to 8.6 ppm.


CONCLUSIONS
This method provides an accurate determination of the amount of coating on a tablet and has general applicability for a variety of coating formulations containing different elements.
Incledon
Chantal
C
Pharmaceutical Development Department, GlaxoSmithKline Inc., 7333 Mississauga Rd. North, Mississauga, ON, Canada L5N 6L4. chantal.h.incledon@gsk.com
Paquet
Chantal
C
Johnston
Andrea
A
Jairam
Rick
R
Dass
Lenny
L
Lam
Herman
H
D019380:Anti-HIV Agents / Q000032:analysis*; D000897:Anti-Ulcer Agents / Q000032:analysis*; D007202:Indicators and Reagents; D019259:Lamivudine / Q000032:analysis*; D011899:Ranitidine / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D013052:Spectrometry, X-Ray Emission; D013608:Tablets, Enteric-Coated / Q000032:analysis*; D014025:Titanium
D019380:Anti-HIV Agents; D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D013608:Tablets, Enteric-Coated; C009495:titanium dioxide; D019259:Lamivudine; D011899:Ranitidine; D014025:Titanium