Formal catalytic asymmetric total synthesis of fostriecin.
The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.
Fujii
Kunihiko
K
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Maki
Keisuke
K
Kanai
Motomu
M
Shibasaki
Masakatsu
M
D000475:Alkenes / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002384:Catalysis; D011090:Polyenes; D011753:Pyrones; D013302:Streptomyces / Q000737:chemistry
D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D011090:Polyenes; D011753:Pyrones; C040313:fostriecin