title: New approach to a novel axially chiral ligand showing spontaneous enrichment of axial chirality.
abstract: We have synthesized novel axially chiral ligand with two chiral centers, (R)-(R)(2)- and (S)-(S)(2)-2,2'-bis(2,2,2-trifluoro-1-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kinetic and thermodynamic resolution is presented which gave these ligands in a much shorter steps, in a higher yield, and in a higher enantiomeric excess.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hirakata, Japan.
authors.forename: Tomokuni
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Omote
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sato
authors.forename: Akira
authors.initials: A
authors.lastname: Ando
authors.forename: Itsumaro
authors.initials: I
authors.lastname: Kumadaki
mesh_terms: D008024:Ligands; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D004364:Pharmaceutical Preparations