Enantiomeric resolution of a series of chiral sulfoxides by high-performance liquid chromatography on polysaccharide-based columns with multimodal elution.
The enantiomeric resolution of a series of 20 asymmetric sulfoxides was systematically investigated by HPLC using multimodal elution with amylose trisR(S)-1-phenylethylcarbamate], amylose tris(3,5-dimethoxyphenylcarbamate) and amylose and cellulose tris(3,5-dimethylphenylcarbamate) phases. The sulfoxide series was composed of aromatic, olefinic and ketosulfoxides, sulfinyl acids and esters. This work has shown that enantioselectivity and enantioresolution of the polysaccharide-based columns can be achieved by changing the type and composition of the mobile phase, widening the applicability of these chiral phases.
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Universidade Federal de São Carlos, Departamento de Química, Caixa Postal 676, 13.565-970 Sio Carlos, SP, Brazil. quezia@dq.ufscar.br
Batigalhia
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D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry / Q000302:isolation & purification*
D011134:Polysaccharides; D013454:Sulfoxides