[Effects of exogenous IL-10 on IL-6 and ICAM-1 expression in inflammatory gingival tissue].
OBJECTIVE
This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.


METHODS
The expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.


RESULTS
IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.


CONCLUSIONS
The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.
Yang
Pishan
P
College of Stomatology, Shandong University.
Qi
Xiangmin
X
Ge
Shaohua
S
Zhao
Min
M
D000328:Adult; D015536:Down-Regulation; D005260:Female; D005881:Gingiva / Q000378:metabolism; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D016753:Interleukin-10 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged
D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10