title: Fatal influenza A virus infection in a child vaccinated against influenza.
abstract: We report a fatal infection with influenza A virus in a 13-year-old child who had been vaccinated against influenza. Influenza A virus RNA was detected by PCR in lungs, bronchi and myocardium. A penicillin-sensitive strain of Staphylococcus aureus was also isolated from her bronchi. This case indicates that a primary viral pneumonia with influenza A virus complicated by a bacterial superinfection with S. aureus can run a fatal course even in a vaccinated child.
authors.affiliation: Kinderklinik, Klinikum Krefeld, Robert-Koch-Institut, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Thomas
authors.forename: Marion
authors.initials: M
authors.lastname: Riffelmann
authors.forename: Brunhilde
authors.initials: B
authors.lastname: Schweiger
authors.forename: Sabine
authors.initials: S
authors.lastname: Dominik
authors.forename: C H Wising
authors.initials: CH
authors.lastname: von König
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents; D001344:Autopsy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D011024:Pneumonia, Viral / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D015163:Superinfection / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D007252:Influenza Vaccines