title: Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei.
abstract: Eleven compounds isolated from the heartwood of Mansonia gagei were tested for their antifungal activities against Cladosporium cucumerinum and Candida albicans, as well as for their larvicidal activities against Aedes aegypti and radical scavenging properties in a DPPH assay. Mansonone C (4) was found to be the most interesting compound with antifungal activities against Cladosporium cucumerinum and Candida albicans as well as for its larvicidal properties against Aedes aegypti. Mansonone E (5) was active against Cladosporium cucumerinum and Candida albicans. Two coumarin derivatives, mansorin A (1) and mansorin B (2) were also found to be active against Cladosporium cucumerinum, while mansonone N (9) was the only isolated product to show radical scavenging properties.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Tiew
authors.forename: J R
authors.initials: JR
authors.lastname: Ioset
authors.forename: U
authors.initials: U
authors.lastname: Kokpol
authors.forename: W
authors.initials: W
authors.lastname: Chavasiri
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D002176:Candida albicans / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D019660:Malvaceae; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010851:Picrates; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014197:Trees
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007306:Insecticides; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl