Late onset polyneuropathy due to organophosphate (DDVP) intoxication.
BACKGROUND
Organophosphate intoxication can cause some well-known life threatening acute neurological complications such as seizures, paralysis, neuromuscular and cardiac conduction disorders. Less often, a predominantly motor and delayed axonal neuropathy can occur. This syndrome is due to inhibition of neuropathy target esterase.


METHODS
A 30-year-old woman attempted suicide by drinking approximately 1,000mg/kg dimethyl-2,2-dichloro vinyl phosphate (DDVP). After a muscarinic and cholinergic syndrome lasting four days, she developed a purely motor distal axonal polyneuropathy on the fifth week after ingestion confirmed by electroneuromyography and sural nerve biopsy. Neurological examination and electroneuromyography revealed a slight recovery at the end of the 21st month.


CONCLUSIONS
This case of late onset polyneuropathy caused by organophosphate intoxication had unusual features such as intact sensory nerves and worse prognosis when compared to previously reported cases.
Sevim
Serhan
S
Department of Neurology, Mersin University, Faculty of Medicine, Mersin, Turkey.
Aktekin
Mustafa
M
Dogu
Okan
O
Ozturk
Hakan
H
Ertas
Mustafa
M
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications / Q000523:psychology; D004006:Dichlorvos / Q000506:poisoning*; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D011115:Polyneuropathies / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D013406:Suicide, Attempted; D013497:Sural Nerve / Q000473:pathology
D007306:Insecticides; D004006:Dichlorvos