Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population.
Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only approximately 20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.
Leigh Brown
Andrew J
AJ
Department of Pathology, University of California, San Diego, California, USA. a.leigh-brown@ed.ac.uk a.leigh-brown@ed.ac.uk
Frost
Simon D W
SD
Mathews
W Christopher
WC
Dawson
Keith
K
Hellmann
Nicholas S
NS
Daar
Eric S
ES
Richman
Douglas D
DD
Little
Susan J
SJ
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D009656:North America / Q000453:epidemiology; D012189:Retrospective Studies; D017211:Treatment Failure; D014505:Urban Population; D019562:Viral Load
D019380:Anti-HIV Agents