title: Quality of life (QoL) as predictive mediator variable for survival in patients with intracerebral neoplasma during radiotherapy.
abstract: BACKGROUND
  The prognosis for patients with malignant astrocytoma or brain metastases is often fatal despite intensive therapy. Therefore we wished to elucidate whether the quality of life (QoL) is a determinant of overall survival (OAS).
  
  
  METHODS
  From 1997 to 2000 153 patients with brain tumours were screened; 39 patients (26%) refused to participate and further 47 patients were excluded (cerebral impairment 14%, amaurosis/ language problems 3%, Karnofsky performance score < 50% 7%, death 8%, non-compliance 7%). Thus, 57 patients were analysed (33 with primary brain tumours, 24 with brain metastases). With the FACT-G questionnaire cancer-specific aspects of health-related QoL were assessed.
  
  
  RESULTS
  Patients with metastases showed a lower QoL in the physical sphere than patients with astrocytoma, but there were no significant differences in OAS. Median survival of patients with good QoL was 31.3 months versus 14.2 months in patients with bad QoL. Only the two variables 'living with a spouse' and FACT-G sum score had a statistically significant influence on survival (p = 0.033 and p = 0.003) modelled by the Cox-PH regression. Patients who did not live with a spouse had shorter survival times than the other patients.
  
  
  CONCLUSIONS
  Health-related QoL can serve to identify a patient group with higher risks of death.
authors.affiliation: Department of Radiotherapy and Radiooncology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany. susanne.sehlen@helios.med.uni-muenchen.de
authors.forename: S
authors.initials: S
authors.lastname: Sehlen
authors.forename: M
authors.initials: M
authors.lastname: Lenk
authors.forename: H
authors.initials: H
authors.lastname: Hollenhorst
authors.forename: B
authors.initials: B
authors.lastname: Schymura
authors.forename: U
authors.initials: U
authors.lastname: Aydemir
authors.forename: P
authors.initials: P
authors.lastname: Herschbach
authors.forename: E
authors.initials: E
authors.lastname: Dühmke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D012044:Regression Analysis; D018570:Risk Assessment; D015996:Survival Rate