The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.
The present research studies the effects of sarmesin [Sar(1)Tyr(OMe)(4)] Angiotensin II (ANG II), an analogue of ANG II, on the seizure susceptibility, memory activity and nociception. It was found that this octapeptide, administered i.c.v., dose-dependently decreased the seizure intensity (pentylenetetrazol (PTZ) generalized seizure model and PTZ kindling) and augmented PTZ seizure threshold in mice. Sarmesin impaired the memory upon re-testing of rats 24 h later in the passive avoidance test. It decreased the pain threshold in a paw pressure nociceptive assay in rats. ANG II exerted pronociceptive effect as well. Taken together, these results reveal sarmesin as a behaviorally active peptide in the studied experimental animal models.
Tchekalarova
J
J
Laboratory Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, AcadG Bonchev Str, Bl23, Sofia 1113, Bulgaria.
Pechlivanova
D
D
Kambourova
T
T
Matsoukas
J
J
Georgiev
V
V
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D007093:Imidazoles / Q000494:pharmacology; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic; D019808:Losartan / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010433:Pentylenetetrazole; D011725:Pyridines / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013623:Tail
D004338:Drug Combinations; D007093:Imidazoles; D011725:Pyridines; D000804:Angiotensin II; C073402:PD 123319; C040420:angiotensin II, Sar(1)-Me-Tyr(4)-; D019808:Losartan; D010433:Pentylenetetrazole