Diagnostic and prognostic value of flow cytometric immunophenotyping in malignant hematological diseases.
Flow cytometry is a diagnostic cell analysis technique with ever increasing applications in modern hematological practice. To date immunophenotyping of clonal hematological diseases represents one of the primary clinical applications of flow cytometry. Immunophenotyping of abnormal cells is now considered a fundamental tool to establish the cell lineage assignment and to obtain a more precise identification of the various cell subtypes. A number of observations have emerged showing strong association between specific immunophenotypes and genetic recurrent abnormalities underlying the malignant transformation, with prognostic value.
Chianese
R
R
Immunohematology and Blood Bank Unit, Legnano Hospital, Legnano, Italy.
Brando
B
B
Gratama
J W
JW
D015415:Biomarkers / Q000032:analysis; D005434:Flow Cytometry / Q000379:methods*; D006402:Hematologic Diseases / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D016130:Immunophenotyping / Q000379:methods*; D007938:Leukemia / Q000175:diagnosis; D008223:Lymphoma / Q000175:diagnosis; D009101:Multiple Myeloma / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers; D007140:Immunoglobulin Fab Fragments