title: Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study.
abstract: Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure-free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy.
authors.affiliation: Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: Darren
authors.initials: D
authors.lastname: Fuerst
authors.forename: Jagdish
authors.initials: J
authors.lastname: Shah
authors.forename: Aashit
authors.initials: A
authors.lastname: Shah
authors.forename: Craig
authors.initials: C
authors.lastname: Watson
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D018450:Disease Progression; D004833:Epilepsy, Temporal Lobe / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012598:Sclerosis