title: PEGylation of the antimicrobial peptide nisin A: problems and perspectives.
abstract: Nisin is a natural antimicrobial peptide produced by Lactococcus lactis and widely employed as food preservative. Its low solubility in neutral aqueous solutions, its instability at physiological pH and its rapid breakdown by proteolytic enzymes has limited its use for processed foods (processed cheese, milk and derivatives, canned vegetables). The conjugation to poly(ethylene glycol) (PEG) could improve its solubility and protect it towards enzymes present in non optimally processed food. We report the synthesis of a PEG-nisin conjugate, and the microbiology assays against some bacterial cell lines.
authors.affiliation: Dipartimento di Science Farmaceutiche, Padua, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Guiotto
authors.forename: Michela
authors.initials: M
authors.lastname: Pozzobon
authors.forename: Mirta
authors.initials: M
authors.lastname: Canevari
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manganelli
authors.forename: Marino
authors.initials: M
authors.lastname: Scarin
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Veronese
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D009561:Nisin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009561:Nisin; D011092:Polyethylene Glycols; C102526:nisin A