Splicing regulation: the cell cycle connection.
Many genes are repressed during mitosis, and this is known to involve differential phosphorylation of specific factors required for transcription, 3'-end RNA processing and translation. A recent study suggests that splicing is also targeted for mitotic repression, in this case by dephosphorylation of the newly identified splicing factor SRp38.
Blencowe
Benjamin J
BJ
C.H. Best Institute, University of Toronto, 112 College Street, Room 410, Toronto, Ontario, Canada M5G 1L6. b.blencowe@utoronto.ca
D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D009363:Neoplasm Proteins; D010766:Phosphorylation; D012326:RNA Splicing; D016601:RNA-Binding Proteins; D012097:Repressor Proteins / Q000502:physiology; D000068103:Serine-Arginine Splicing Factors
D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; C115188:SRSF10 protein, human; D000068103:Serine-Arginine Splicing Factors