title: Vocal outcome after endoscopic cordectomies for Tis and T1 glottic carcinomas.
abstract: A cohort of 101 patients with previously untreated glottic cancer (15 Tis, 66 T1a, and 20 T1b) who underwent endoscopic CO2 laser excision between January 1995 and December 1997 was prospectively analyzed. The depth and extension of the excision were graded according to the European Laryngological Society Classification including 5 types of cordectomy. All patients were subsequently examined every 2 months for a period ranging from 30 to 66 months (mean, 48 months). The rates of 5-year overall survival, disease-free survival, ultimate local control with laser alone, and laryngeal preservation were 85%, 87%, 93%, and 95%, respectively. Sixty-nine patients underwent, at least 1 year after surgery, videolaryngostroboscopy combined with perceptual and objective evaluation of the voice, and spirometry. Acoustic parameters were compared with those obtained in a matched control group by Kruskal-Wallis test. No statistically significant difference was found (p > .05) between patients submitted to subepithelial (type I) and subligamental (type II) cordectomies and controls.
authors.affiliation: Department of Otolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Peretti
authors.forename: Cesare
authors.initials: C
authors.lastname: Piazza
authors.forename: Cristiano
authors.initials: C
authors.lastname: Balzanelli
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cantarella
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000145:classification / Q000401:mortality / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007828:Laryngoscopy / Q000379:methods*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013061:Speech Acoustics; D013068:Speech Production Measurement; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D014833:Voice Quality