title: PopHist: inferring population history from the spectrum of allele frequencies.
abstract: CONCLUSIONS
  PopHist is a computer program that uses the frequency spectrum of alleles to: (a) estimate maximum likelihood parameters describing a population's history; and (b) compare alternative hypotheses about population history using likelihood ratio tests. The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked sites.
  
  
  BACKGROUND
  Source code and documentation are available at http://mombasa.anthro.utah.edu/wooding/PopHist
authors.affiliation: Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112-5330, USA. swooding@genetics.utah.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Wooding
mesh_terms: D000465:Algorithms; D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D003198:Computer Simulation; D004252:DNA Mutational Analysis / Q000379:methods*; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D011110:Polymorphism, Genetic / Q000235:genetics; D011153:Population; D011157:Population Dynamics; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software