title: Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.
abstract: Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. macg@usal.es
authors.forename: Angeles
authors.initials: A
authors.lastname: Castro
authors.forename: José M Miguel
authors.initials: JM
authors.lastname: del Corral
authors.forename: Marina
authors.initials: M
authors.lastname: Gordaliza
authors.forename: Concepción
authors.initials: C
authors.lastname: Grande
authors.forename: Antonia
authors.initials: A
authors.lastname: Gómez-Zurita
authors.forename: Dolores
authors.initials: D
authors.lastname: García-Grávalos
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D004146:Dioxanes / Q000138:chemical synthesis / Q000494:pharmacology; D004149:Dioxoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004146:Dioxanes; D004149:Dioxoles; D017705:Lignans; C040539:1,3-benzodioxole; D011034:Podophyllotoxin