New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity.
Bis(pyridyl)methane derivatives 5-40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5-40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-5) M level and in some case at 10(-7) M concentrations.
Cocco
Maria Teresa
MT
Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. tcocco@unica.it
Congiu
Cenzo
C
Onnis
Valentina
V
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008697:Methane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008956:Models, Chemical; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011725:Pyridines; D011728:Pyridones; C039659:2,4-dihydroxypyridine; D008697:Methane