title: Embryonic expression of Tbx1, a DiGeorge syndrome candidate gene, in the lamprey Lampetra fluviatilis.
abstract: We report the embryonic expression in the lamprey Lampetra fluviatilis of Tbx1, the main candidate gene involved in DiGeorge/velo-cardio-facial syndrome (DGS/VCFS). From the end of neurulation to stage 26, Tbx1 becomes progressively expressed in all developing pharyngeal arches, as they form. Transcripts are mainly restricted to the mesodermal core and to the posterior pharyngeal endoderm, excluding ingressing neural crest cells. They are also present in the otic vesicle, in a ventral and posterior location. From a later stage (stage 27) onwards, additional expression domains in the head mesenchyme, later contributing to labial muscle precursors, and in the cloacal region, become visible. The comparison of these data with those reported in the chick and the mouse indicates a high conservation of Tbx1 expression in the pharyngeal arches among vertebrates.
authors.affiliation: Equipe Développement et Evolution des Vertébrés, UPRES-A 8080, Université Paris- Sud, 91405 Orsay Cedex, France.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Sauka-Spengler
authors.forename: Chantal
authors.initials: C
authors.lastname: Le Mentec
authors.forename: Mario
authors.initials: M
authors.lastname: Lepage
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mazan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004062:DiGeorge Syndrome / Q000235:genetics; D005260:Female; D017403:In Situ Hybridization; D007798:Lampreys / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D020825:T-Box Domain Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D020825:T-Box Domain Proteins; C491573:Tbx1 protein, mouse