Unexpected distribution of hepatitis C virus genotypes in patients on hemodialysis and kidney transplant recipients.
The distribution of hepatitis C virus (HCV) genotypes in patients on hemodialysis and in kidney transplant recipients was compared with that observed in a control group composed of HCV-infected individuals from the general population. A total of 340 patients were included in the study: 46 with end-stage renal disease on regular hemodialysis treatment, 22 kidney transplant recipients and 272 controls matched for sex and age at a 4:1 ratio (controls to patient). HCV genotype was determined by sequencing of the 5' untranslated region of the HCV genome. No difference was observed in the distribution of HCV genotypes in hemodialysis patients and renal transplant patients (P = 0.47). However, when each of these groups was compared with the control group, a significant difference was detected in the genotype distribution (P < 0.001). In hemodialysis and renal transplant patients the most prevalent subtype was 1a, followed by 1b, 3, and other less prevalent genotypes (2, 4, and 5), whereas in the control group the most prevalent subtype was 1b, followed by 3, 1a, and others. That observation may reflect differences in the epidemiology of HCV infection, viral characteristics and host factors in renal patients in comparison to the control group.
Perez
Renata M
RM
Division of Gastroenterology, Universidade Federal de São Paulo, Brazil.
Ferraz
Maria Lucia G
ML
Figueiredo
Mauro S
MS
Contado
Denilson
D
Koide
Sandra
S
Ferreira
Adalgisa P
AP
Cendoroglo Neto
Miguel
M
Medina Pestana
José O
JO
Silva
Antonio Eduardo B
AE
D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D017422:Sequence Analysis, DNA
D020121:5' Untranslated Regions