title: Extracorporeal photochemotherapy in the treatment of eosinophilic fasciitis.
abstract: BACKGROUND
  Eosinophilic fasciitis (EF) is a rare connective tissue disorder characterized clinically by symmetrical swelling, induration and thickening of the skin and histologically by thickening of the fascia with chronic inflammatory infiltrate containing eosinophils. The disease is classified in the spectrum morphea/systemic sclerosis and treated with systemic steroids and other immunosuppressant drugs.
  
  
  OBJECTIVE
  The purpose of this study was to use extracorporeal photochemotherapy (ECP) in patients with EF to evaluate the effectiveness of this therapy.
  
  
  METHODS
  Three patients affected by EF were treated with ECP because they failed to respond or with contraindications to immunosuppressant treatment. The patients underwent ECP with a UVAR XTS apparatus. Subjects were treated on two consecutive days at 2-week intervals for the first 3 months and thereafter every 4 weeks on the basis of clinical response. The patients were assessed before therapy and then monthly by means of a clinical score. Changes in affected areas were evaluated at predetermined points by computerized skin elastometry (Cutometer SEM 474).
  
  
  RESULTS
  After 1 year of therapy we found considerable improvement of clinical parameters in two cases. There was less striking improvement in the other case. These clinical results were confirmed by the elastometry measurements. All patients reported improved quality of life, which enabled a reduction in the dose of immunosuppressants.
  
  
  CONCLUSIONS
  ECP emerged as a safe and effective therapy in association with low doses of immunosuppressants in our three patients. A randomized comparative multicentre study between ECP as single therapy and ECP plus immunosuppressants and conventional therapies is required to firmly establish photopheresis as a possible basic treatment to combine with conventional therapies for EF.
authors.affiliation: Department of Dermatology, University of Siena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Romano
authors.forename: P
authors.initials: P
authors.lastname: Rubegni
authors.forename: G
authors.initials: G
authors.lastname: De Aloe
authors.forename: E
authors.initials: E
authors.lastname: Stanghellini
authors.forename: G
authors.initials: G
authors.lastname: D'Ascenzo
authors.forename: L
authors.initials: L
authors.lastname: Andreassi
authors.forename: M
authors.initials: M
authors.lastname: Fimiani
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D004548:Elasticity; D004802:Eosinophilia / Q000188:drug therapy*; D005208:Fasciitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017893:Photopheresis / Q000379:methods
chemical_list: D000305:Adrenal Cortex Hormones; D016572:Cyclosporine