title: Formal catalytic asymmetric total synthesis of fostriecin.
abstract: The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Fujii
authors.forename: Keisuke
authors.initials: K
authors.lastname: Maki
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002384:Catalysis; D011090:Polyenes; D011753:Pyrones; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D011090:Polyenes; D011753:Pyrones; C040313:fostriecin