[The photostability of hydrocortisone injection].
OBJECTIVE
This experiment was designed to make known wether the photostability of drugs in daylight can be obtained from lamplight exposure.


METHODS
A self made cumulative illuminometer via pulse counting method was used for measuring cumulative illuminance of daylight to investige the photodegradation of Hydrocortisone injection in various lamp light and daylight; the equivalent influences of different light sources on the photostability of the injection were obtained, and the shelf-life in indoor daylight of the drug was predicted.


RESULTS
The photodegradation of Hydrocortisone injection obeys zero order kinetics: C = C0-kEt; the shelf-life in indoor daylight of the injection in nude ampoules was predicted as 36 days and is comparable to 35 days in a long-term storage test.


CONCLUSIONS
The photostability of drugs in daylight can be obtained from lamplight exposure experiment.
Lin
T
T
School of Pharmacy, WCUMS, Chengdu 610041, China.
Li
K
K
Li
C
C
Qiu
C
C
Zhan
X
X
D004355:Drug Stability; D006854:Hydrocortisone; D007267:Injections; D008027:Light
D006854:Hydrocortisone