title: Effects of childhood respiratory diseases on the anatomical and functional development of the respiratory system.
abstract: The anatomical and functional development of the lung appears especially vulnerable to a whole range of insults during gestation and the first few years of life. A significant proportion of adult lung disease originates in utero or early infancy. Most publications on this topic are descriptive retrospective studies. An important limitation of these is that structural changes may precede abnormalities in lung function and development of symptoms. Little is known with certainty with respect to the long-term effects of early insults to the respiratory system. Furthermore, the reversibility of the functional and/or structural defects is hardly ever adequately investigated and it is probably not correct to extrapolate findings from adult studies to paediatric pulmonary diseases. Promoting or facilitating optimal lung growth in fetuses and infants and reducing the incidence of lower respiratory tract infection in infancy may reduce the incidence of adult chronic lung disease in generations to come.
authors.affiliation: Department of Paediatrics/Respiratory Medicine, Sophia Children's Hospital, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands. merkus@alkg.azr.nl
authors.forename: Peter J F M
authors.initials: PJ
authors.lastname: Merkus
mesh_terms: D002648:Child; D002821:Chorioamnionitis / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*; D011247:Pregnancy; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000401:mortality / Q000503:physiopathology; D014057:Tomography, X-Ray Computed