Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma.
Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemical expression of Mel-CAM in 41 parotid MEC was correlated with clinical parameters. Ten cases of oral cavity SCC were included for comparison. Mel-CAM expression was found in 92.7% of the MEC but was not expressed by the SCC. Mel-CAM expression was greater in intermediate/high grade tumors, was weaker in patients that presented local recurrence, regional and distant metastasis, but no correlation between Mel-CAM and clinical stage and survival of the patients was found. Decreased Mel-CAM expression can impair cellular contact properties, facilitating growth, cell spreading and metastasis in MEC. Mel-CAM can also be useful in differentiating high grade MEC from SCC.
Pires
Fábio Ramôa
FR
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, no. 157, CEP: 21550-030, Rio de Janeiro/RJ, Brazil.
Shih
Ie-Ming
IeM
da Cruz Perez
Danyel Elias
DE
de Almeida
Oslei Paes
OP
Kowalski
Luiz Paulo
LP
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism; D051929:CD146 Antigen; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000378:metabolism* / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D019006:Neural Cell Adhesion Molecules; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D051929:CD146 Antigen; C497902:MCAM protein, human; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D019006:Neural Cell Adhesion Molecules