Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats.
In the course of anthracyclin administration, melatonin acts as an effective scavenger of oxygen free radicals and exerts cardio- and nephroprotective effects. The present study aimed at corroborating cytostatic effectiveness of daunorubicin, applied in parallel with melatonin, in rats with transplanted Morris hepatoma. The percentage of tumour cells, which manifested traits of necrosis was recorded and extent of apoptosis was evaluated in tumour cells and in cells of myocardium. Daunorubicin administration was followed by a significant increase in necrosis and apoptosis in tumour cells and by intensified apoptosis in myocardium cells. Melatonin administered in parallel with daunorubicin decreased the extent of necrosis in tumour cells and reduced the proportion of apoptotic cardiomyocytes.
Dziegiel
Piotr
P
Department of Histology and Embryology, University School of Medicine, Wrocław. piotr@hist.am.wroc.pl
Surowiak
Paweł
P
Rabczyński
Jerzy
J
Zabel
Maciej
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D003630:Daunorubicin / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D020287:In Situ Nick-End Labeling; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008550:Melatonin / Q000494:pharmacology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D014407:Tumor Cells, Cultured / Q000637:transplantation
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D008550:Melatonin; D003630:Daunorubicin