Familial clustering of hepatitis B infection: study of a family.
Familial clustering of hepatitis B virus infection has been reported infrequently. We report a family of 27 members, where 13 members were HBsAg-positive. This included 7 of 10 members in one linear family across four generations. Nine subjects who were tested were HBeAg-negative. Of these nine, three subjects had elevated ALT; histology in one of them showed activity index <3. One subject received lamivudine therapy elsewhere; ALT levels returned to normal in two months.
Verma
Govind
G
Department of Gastroenterology, Seth G S Medical College and K E M Hospital, Mumbai 400 012.
Dalai
Prakash
P
Bapat
Mukta
M
Rathi
Pravin
P
Abraham
Philip
P
D000293:Adolescent; D000328:Adult; D002648:Child; D016000:Cluster Analysis; D005260:Female; D006509:Hepatitis B / Q000235:genetics*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006514:Hepatitis B Surface Antigens