title: Effect of regular exercise on coronary endothelial function in patients with recent myocardial infarction.
abstract: Exercise training improves the endothelial function of arteries in skeletal muscle, but few studies have examined its clinical effect on human coronary endothelial function. Non-infarct-related coronary arteries in 41 patients with a recent myocardial infarction who underwent successful percutaneous transluminal coronary angioplasty were studied. Patients were divided into 2 groups: regular exercisers (n=24, 17 males, mean age: 58 years), and non-exercisers (n=17, 12 males, mean age: 58 years). Acetylcholine (ACh) was infused into the non-infarct-related coronary artery and its diameter was measured by quantitative angiography at baseline and at 6 months after angioplasty. ACh, given in doses of 1, 3, 10, 30 microg/min, increased the coronary artery diameter in a dose-dependent manner in both groups. The mean percent change in the diameter at the site of stenosis change (%DS) was less in the regular exercisers than in the non-exercisers (11%+/-12 vs 41%+/-36, p<0.05). Multivariate analysis showed that regular exercise was the only significant determinant of improvement in endothelial function (p=0.01). These findings suggest that regular exercise improves endothelial function in the coronary arteries following myocardial infarction.
authors.affiliation: Division of Cardiology, Tokushima Red Cross Hospital, Komatsushima, Japan. hoso@tokushima-med.jrc.or.jp
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Takefumi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000502:physiology*; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology
chemical_list: D000109:Acetylcholine