title: Fibrinolysis of mechanical prosthetic valve thrombosis: a single-center study of 127 cases.
abstract: OBJECTIVE
  This study was designed to analyze the results of fibrinolytic treatment (FT) in a large single-center group of patients with prosthetic heart valve thrombosis (PHVT).
  
  
  BACKGROUND
  Fibrinolytic treatment of PHVT represents an alternative to surgery, but is still controversial because of the risk of embolism.
  
  
  METHODS
  A total of 110 consecutive patients presenting with 127 instances of PHVT received FT between 1978 and 2001. The diagnosis of PHVT was established mainly by fluoroscopy and/or echocardiography. The first fibrinolytic agent used was streptokinase (SK) in 49 cases, urokinase (UK) in 41 cases, and recombinant tissue-type plasminogen activator (rtPA) in 37 cases. A second FT was consecutively infused in 38 patients (30%) and a third FT in 11 others. The efficacy of FT was assessed from hemodynamic parameters derived from echographic examinations as well as on clinical grounds.
  
  
  RESULTS
  Complete resolution of hemodynamic abnormalities was seen in 90/127 patients, partial resolution in 22/127 patients, and no change in 15/127 patients after one or more consecutive fibrinolytic regimens. When SK or rtPA were used as the first fibrinolytic agent, they appeared significantly superior to UK in terms of valve reopening. Fifteen patients died. Severe hemorrhagic complications were observed in six patients. Nineteen documented embolic events occurred during FT. Finally, PHVT recurred in 24 patients, 17 of whom were retreated with lytic agents.
  
  
  CONCLUSIONS
  These results indicate that FT is effective in most cases of PHVT, regardless of prosthesis or site involved. However, embolism, hemorrhage, and death were not uncommon after lytic therapy of left-sided PHVT, limiting its application to patients at high risk with alternative treatment.
authors.affiliation: I.F.R. 4 - F.R. 21 Coeur-Poumons-Vaisseaux-Thrombose, Hôpital Cardiologique Haut-Lévêque, CHU de Bordeaux, 33604 Pessac, France. raymond.roudaut@pu.u-bordeaux2.fr
authors.forename: Raymond
authors.initials: R
authors.lastname: Roudaut
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lafitte
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Roudaut
authors.forename: Carine
authors.initials: C
authors.lastname: Courtault
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Perron
authors.forename: Catherine
authors.initials: C
authors.lastname: Jaïs
authors.forename: Xavier
authors.initials: X
authors.lastname: Pillois
authors.forename: Pierre
authors.initials: P
authors.lastname: Coste
authors.forename: Anthony
authors.initials: A
authors.lastname: DeMaria
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000009:adverse effects / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D013300:Streptokinase / Q000009:adverse effects / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D013300:Streptokinase; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator