Effect of vitamin C on endothelial dysfunction during N-alpha-tosyl L-arginine methyl ester [TAME]-esterase induced contractions in rat aorta in vitro.
Contractions induced by TAME-esterase on rat aorta strips mounted in vitro were significantly inhibited in presence of Vitamin C. The work lends support to the role of ascorbic acid in preventing endothelial dysfunction through release of nitric oxide. It is suggested that conclusions TAME-esterase could be an important biological marker associated with onset of vascular discases such as hypertension.
Gurib
F B H
FB
Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
Subratty
A H
AH
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000502:physiology; D001205:Ascorbic Acid / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010447:Peptide Hydrolases / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase; D001205:Ascorbic Acid