title: [Study on GSTs activity in trinitrotoluene cataract].
abstract: OBJECTIVE
  To direct the relationship between the activity of glutathione S-transferases(GSTs) and susceptibility to trinitrotoluene cataract (TC).
  
  
  METHODS
  KMSL method was used to test the activity of GSTs in 154 cases of TC(group A), 41 cases of non-trinitrotolune cataract (group B), and 40 normal subjects (group B).
  
  
  RESULTS
  The activity of GSTs in group TC was significantly lower than that in the two control groups (P < 0.01). The differences in GSTs activity were highly significant between the four stages of TC (P < 0.01), in which the sequence of GSTs activity levels from high to low was the stage of observation, stage I, stage II, and stage III. Compared to the persons with gst mu gene, the persons without gst mu gene had significantly lower GSTs activity (P < 0.01). It was found that the GSTs activity of the persons without gst mu gene in TC group was significantly lower than that of the persons without gst mu gene in the two control groups (P < 0.01), but the differences in GSTs activity between the persons with gst mu gene among the three groups were not significant (P > 0.05). The most noticeable correlation was observed between GSTs activity gst mu gene deletion (r = 0.702, P < 0.01).
  
  
  CONCLUSIONS
  TC and its stages are closely correlated with the activity of GSTs.
authors.affiliation: Department of Occupational Health, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Changji
authors.initials: C
authors.lastname: Li
authors.forename: Yunfang
authors.initials: Y
authors.lastname: Long
authors.forename: Chenglie
authors.initials: C
authors.lastname: Zhan
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D002386:Cataract / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D014303:Trinitrotoluene
chemical_list: D014303:Trinitrotoluene; D005982:Glutathione Transferase