title: Discovery of the first antibacterial small molecule inhibitors of MurB.
abstract: A series of imidazolinone analogues was synthesized and shown to possess potent MurB inhibitory as well as good antibacterial activity.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: DenBleyker
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Falk
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mate
authors.forename: Hsu-Tso
authors.initials: HT
authors.lastname: Ho
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pucci
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Snyder
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002237:Carbohydrate Dehydrogenases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007093:Imidazoles; D002237:Carbohydrate Dehydrogenases; C023215:UDP-N-acetylmuramate dehydrogenase