Motion sickness and vestibular hypersensitivity.
OBJECTIVE
Motion sickness is poorly understood, although it has been recognized for years as debilitating. Vestibular function is required for motion sickness to occur, but motion sickness can also be brought on without body motion. The aim of this study was to see if there was a correlation between caloric response and motion sickness susceptibility.


METHODS
One experiment was a prospective study carried out on 200 patients. A second prospective study was carried out on 121 patients.


METHODS
Patients referred to our tertiary/quaternary care dizziness clinic.


METHODS
In experiment 1, caloric scores in patients were correlated with symptoms of motion sickness as established by responses to a simple question. In experiment 2, caloric scores were correlated with symptomatic responses to caloric testing itself.


METHODS
Caloric responses of the best ear were measured according to standardized caloric evaluation methods.


RESULTS
There was no correlation between motion sickness and caloric scores. There was a significant difference in caloric scores between patients made symptomatic by calorics and those who were not.


CONCLUSIONS
The autonomic response seen in some patients is not triggered by a specific level of semicircular canal response (as measured by caloric testing). We hypothesize that (similar to space motion sickness) the trigger is a signal differential that arises between semicircular canals and otoliths and that some patients are unable to suppress this response. These patients often suffer motion sickness on a long-term basis.
Mallinson
Arthur I
AI
Neuro-otology Unit, Vancouver General Hospital, British Columbia.
Longridge
Neil S
NS
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology*; D002150:Caloric Tests; D004198:Disease Susceptibility; D006801:Humans; D008875:Middle Aged; D009041:Motion Sickness / Q000209:etiology* / Q000503:physiopathology*; D010037:Otolithic Membrane / Q000503:physiopathology; D010812:Physical Stimulation; D011446:Prospective Studies; D011930:Reaction Time / Q000502:physiology; D012720:Severity of Illness Index; D015837:Vestibular Diseases / Q000150:complications* / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology*