title: S(R)-podolactone D, a new sulfoxide-containing norditerpene dilactone from Podocarpus macrophyllus var. maki.
abstract: S(R)()-Podolactone D (1), a new norditerpene dilactone having a methylsulfoxide moiety, was isolated from the leaves of Podocarpus macrophyllus D. Don var. maki Endl. along with known podolactone D (2, S(S)()-podolactone D). The structures and absolute configurations of compounds 1 and 2 were elucidated by spectral methods (HREIMS, IR, (1)H, (13)C, and 2D NMR) and finally confirmed by single-crystal X-ray analyses. The cytotoxic effects of compounds 1 and 2 on P388 murine leukemia cells were also examined.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Park
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukaya
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D018360:Crystallography, X-Ray; D032462:Cycadopsida / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007783:Lactones; C475245:S(R)-podolactone D; D013454:Sulfoxides; D013729:Terpenes; C008943:podolactone A