Clinical evaluation of the Elecsys CA 15-3 test in breast cancer patients.
The aim of the present study was to evaluate the clinical performance of the CA 15-3 assay on Elecsys systems in an international multicenter study (11 centers). A total of 1326 single samples (272 apparently healthy individuals, 34 pregnant women, 308 benign diseases, 273 cancers other than breast, 439 breast cancer) and 538 serial samples of 98 breast cancer patients during follow-up were analyzed. 95% of values in healthy individuals were below 25 kU/L, and 88% in benign breast diseases, respectively. In malignant breast disease at primary diagnosis the value distribution of Elecsys CA 15-3, sensitivity at 95% specificity, as well as the areas under the curve in ROC analysis were clearly correlated to tumor stages: UICC I to IV 88 to 25% of values < 25 kU/L, sensitivity 7 to 78%, areas under the curve 0.53 to 0.94. During follow-up, sensitivity/specificity for detection of recurrences were 90%/71%. In metastatic disease clinical progression/response to therapy were indicated in 91%/78% of patients at a specificity of 92%/78%. The findings indicate that the Elecsys CA 15-3 assay is very suitable in routine work for detection of recurrences as well as for therapy control in metastatic breast cancer.
Stieber
Petra
P
Klinikum der Universität München -Grosshadern-, Institut für Klinische Chemie, Munich, Germany. stieber@klch.med.uni-muenchen.de
Molina
Rafael
R
Chan
Daniel W
DW
Fritsche
Herbert A
HA
Beyrau
Ralf
R
Bonfrer
Jean M G
JM
Filella
Xavier
X
Gornet
Terrie G
TG
Hoff
Torsten
T
Jäger
Wolfram
W
van Kamp
Gerard J
GJ
Nagel
Dorothea
D
Peisker
Klaus
K
Sokoll
Lori J
LJ
Troalen
Frédéric
F
Untch
Michael
M
Domke
Ingrid
I
D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood; D012016:Reference Values; D012189:Retrospective Studies; D014481:United States
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018396:Mucin-1