Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats.
The synergistic protective effect of Nicorandil (K(ATP) channel opener) and Amlodipine (calcium channel blocker) on heart tissue antioxidant defense system and lipid profile were examined on isoproterenol induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed significant changes in antioxidant defense system and lipid profile levels. Pretreatment with Nicorandil (2.5 mg kg(-1) daily, p.o.) and Amlodipine (5.0 mg kg(-1) daily, p.o.) for 3 days significantly prevented these alterations and restored the enzyme activities to near normal. These findings indicate the synergistic protective effect of Nicorandil and Amlodipine on tissue defense system and lipid metabolism during isoproterenol induced cardiac damage.
Sathish
Venkatachalem
V
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, India.
Ebenezar
Kesavarao Kumar
KK
Devaki
Thiruvengadam
T
D017311:Amlodipine / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D004357:Drug Synergism; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D020108:Nicorandil / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000959:Antihypertensive Agents; D000975:Antioxidants; D005227:Fatty Acids; D008074:Lipoproteins; D017311:Amlodipine; D020108:Nicorandil; D002784:Cholesterol