RNA sequences that work as transcriptional activating regions.
We describe a set of RNA molecules that work as transcriptional activators when tethered to DNA. These RNA activating regions were found amongst a randomized set of molecules bearing variants of a 10 nt loop attached to an RNA stem. The various RNA activating regions all bear an identical five- residue sequence with an interspersed sixth residue. The result shows that although all natural activating regions characterized thus far are peptidic, this function can be served by other kinds of moieties as well.
Saha
Shamol
S
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Ansari
Aseem Z
AZ
Jarrell
Kevin A
KA
Ptashne
Mark
M
Jarell
Kevin A
KA
D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000235:genetics; D012313:RNA / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015533:Transcriptional Activation / Q000235:genetics*
D009843:Oligoribonucleotides; D012313:RNA