title: [Effective transarterial neoadjuvant chemotherapy with paclitaxel (TXL) in a case of locally advanced breast cancer].
abstract: The patient was a 49-year-old woman who had locally advanced breast cancer with skin invasion. She was placed on neoadjuvant weekly systemic chemotherapy of TXL (65 mg/m2) and ADM (20 mg/m2). After systemic chemotherapy, she underwent 2 courses of transarterial neoadjuvant chemotherapy of TXL (day 1, 8, 15). We administered TXL (45 mg/m2) into the subclavian artery and TXL (20 mg/m2) into the internal thoracic artery. Although she experienced grade 3 leukopenia during systemic chemotherapy, she experienced only grade 2 alopecia and grade 1 nausea during transarterial chemotherapy. After chemotherapy, she underwent radical mastectomy. We report herein a case in which transarterial neoadjuvant chemotherapy with TXL was effective.
authors.affiliation: Dept. of Surgery, Miyazaki Prefectural Nobeoka Hospital.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Koga
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Ohchi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kudo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishiodori
authors.forename: Takashi
authors.initials: T
authors.lastname: Ochiai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muranaka
authors.forename: Akira
authors.initials: A
authors.lastname: Ishihara
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D015409:Mastectomy, Radical; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D017239:Paclitaxel / Q000008:administration & dosage*; D013348:Subclavian Artery; D013895:Thoracic Arteries
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004317:Doxorubicin; D017239:Paclitaxel