title: Coenzyme Q10 and cardiovascular disease: a review.
abstract: This article provides a comprehensive review of 30 years of research on the use of coenzyme Q10 in prevention and treatment of cardiovascular disease. This endogenous antioxidant has potential for use in prevention and treatment of cardiovascular disease, particularly hypertension, hyperlipidemia, coronary artery disease, and heart failure. It appears that levels of coenzyme Q10 are decreased during therapy with HMG-CoA reductase inhibitors, gemfibrozil, Adriamycin, and certain beta blockers. Further clinical trials are warranted, but because of its low toxicity it may be appropriate to recommend coenzyme Q10 to select patients as an adjunct to conventional treatment.
authors.affiliation: Department of Nursing, University of Southern California, Los Angeles, California, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sarter
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D000529:Complementary Therapies / Q000379:methods*; D003327:Coronary Disease / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy; D014451:Ubiquinone / Q000172:deficiency / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014451:Ubiquinone