Signaling from novel splice variants of hormone receptors in cancer.
A number of splice variants of hormone receptors have recently been described in malignant neoplasms. Signaling by these novel receptor isoforms differ from their wild type counterparts, raising interesting questions as to possible roles in the initiation, progression, and metastatic potential of various tumors. This review summarizes recent findings on the signaling of novel variants of hormone receptors, including human HER-2/neu, the secretin receptor, the CCK-B/gastrin receptor and fibroblast growth factor receptor-2.
Ding
Wei-Qun
WQ
Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Miller
Laurence J
LJ
D006801:Humans; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000503:physiopathology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D043887:Receptor, Cholecystokinin B; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology*; D051497:Receptor, Fibroblast Growth Factor, Type 2; D011949:Receptors, Cholecystokinin / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone / Q000502:physiology*; D015398:Signal Transduction
D020794:Receptor Protein-Tyrosine Kinases; D043887:Receptor, Cholecystokinin B; D018719:Erb-b2 Receptor Tyrosine Kinases; D051497:Receptor, Fibroblast Growth Factor, Type 2; D011949:Receptors, Cholecystokinin; D017468:Receptors, Fibroblast Growth Factor; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor; C496353:FGFR2 protein, human