Effect of ginsenoside Rb1 on long-term potentiation in the dentate gyrus of anaesthetized rats.
Ginsenosides are the major principles of Panax ginseng and have various pharmacological actions on the central nervous system. In this report, we investigated whether ginsenoside Rb1 (10, 100 nmol(-1), icv) could increase the population spike (PS) amplitude in a dose-dependent manner, and accelerate the maintenance phase of long-term potentiation (LTP) induced by high frequency stimulation (HFS) in the dentate gyrus of anaesthetized rats. However, it had no effect on basic synaptic responses evoked by test stimulation. Comparatively, ginsenoside Rb1 (10, 100 nmol l(-1), icv) inhibited the induction phase of LTP induced by HFS in a dose-dependent manner. This may be one of the mechanisms of action of ginsenoside Rb1 on synaptic transmission. The details of the mechanism need further investigation.
Wang
Xiao-Ying
XY
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
Zhang
Jun-Tian
JT
D000818:Animals; D002404:Catheterization; D002552:Cerebral Ventricles; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D036145:Ginsenosides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D005894:Panax; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D036145:Ginsenosides; C442759:ginsenoside Rb1