title: Pregnancy alters hemodynamic responses to hemorrhage in conscious rabbits.
abstract: Pregnant animals are less able to maintain mean arterial pressure (MAP) during hemorrhage compared with nonpregnant animals, but the hemodynamic basis of this difference is unknown. The hypothesis that pregnancy attenuates responses of cardiac output, as well as total peripheral resistance (TPR) and femoral conductance, to hemorrhage was tested in conscious rabbits in both the pregnant and nonpregnant state (n = 10). During continuous slow blood loss (2% of the initial blood volume per minute), MAP was maintained initially in both groups. However, MAP then abruptly decreased to <45 mmHg in all animals after a smaller percentage of the initial blood volume was removed in pregnant compared with nonpregnant rabbits (43.6 +/- 1.7%, nonpregnant; 29.6 +/- 2.2%, pregnant; P < 0.005). The more rapid transition to hypotension exhibited by pregnant rabbits was associated with greater initial falls in cardiac output (-56 +/- 10 ml/min, nonpregnant; -216 +/- 33 ml/min, pregnant; P < 0.005) and stroke volume (0.8 +/- 0.1 ml/beat, nonpregnant; -1.3 +/- 0.1 ml/beat, pregnant; P < 0.05). In addition, the increase in TPR as a function of the decrease in cardiac output was markedly attenuated (P < 0.0001) during pregnancy. Whereas femoral conductance decreased in nonpregnant rabbits, it did not change significantly in pregnant animals. In conclusion, the lesser ability of conscious pregnant rabbits to maintain MAP during hemorrhage is due largely to a greater decrease in cardiac output but also to inadequate reflex increases in TPR, possibly in part in the femoral vascular bed.
authors.affiliation: Department of Physiology and Pharmacology, Oregon Health & Science University, Portland 97239, USA.
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Clow
authors.forename: George D
authors.initials: GD
authors.lastname: Giraud
authors.forename: Bryan E
authors.initials: BE
authors.lastname: Ogden
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Brooks
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D001810:Blood Volume; D002302:Cardiac Output; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006400:Hematocrit; D006439:Hemodynamics; D006470:Hemorrhage; D007700:Kinetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011817:Rabbits
chemical_list: D001798:Blood Proteins