Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia.
Common variable immunodeficiency (CVID) is characterized by a severe hypogammaglobulinemia. While the clinical picture is dominated by recurrent respiratory and gastrointestinal infections, a subgroup of up to 30% of the patients develops additional autoimmune phenomena, including thrombocytopenia and autoimmune hemolytic anemia. So far no classification allowed a prediction of the coincidence of immunodeficiency and autoimmunity. Here, we propose the size of the peripheral CD19(hi)CD2(lo/neg) B cell pool as a marker for CVID patients with autoimmune cytopenia and splenomegaly. Interestingly similar B cell populations are also found in patients with SLE and may not only be an epiphenomenon of the disease.
Warnatz
Klaus
K
Division of Rheumatology and Clinical Immunology, Dept. of Medicine, University Hospital Freiburg, Germany. warnatz@mm61.ukl.uni-freiburg.de
Wehr
Claudia
C
Dräger
Ruth
R
Schmidt
Sigune
S
Eibel
Hermann
H
Schlesier
Michael
M
Peter
Hans-Hartmut
HH
D000328:Adult; D018941:Antigens, CD19 / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002452:Cell Count; D002648:Child; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000145:classification* / Q000150:complications / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007970:Leukopenia / Q000209:etiology / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D017464:Receptors, Complement 3d / Q000276:immunology; D013163:Splenomegaly / Q000209:etiology / Q000276:immunology
D018941:Antigens, CD19; D017464:Receptors, Complement 3d