title: Impact of antiretroviral therapy and changes in virus load on human immunodeficiency virus (HIV)-specific T cell responses in primary HIV infection.
abstract: Human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T cell responses were evaluated prospectively in a large cohort of subjects with HIV primary infection via long-term follow-up examining different virological profiles related to different treatment interventions. No correlation was observed between baseline virus load and HIV-specific CD4(+) and CD8(+) T cell responses. Highly active antiretroviral therapy (HAART)-induced suppression of viremia was associated with an increase in CD4(+) T cell proliferative responses. The HIV-specific proliferative response also increased, at least in the first 18 months, in subjects with detectable viremia, either treated or untreated. The magnitude of the HIV-specific CD8(+) T cell response decreased with suppression of viremia. In subjects with detectable viremia, the breadth and magnitude of the HIV-specific CD8(+) T cell responses increased progressively. Finally, whether HAART was initiated before or after seroconversion had little effect on HIV-specific CD4(+) and CD8(+) T cell responses.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) E0109, Immunité Antivirale Systémique et Cérébrale, Faculté de Médecine Paris Sud, 63 rue Gabriel Péri, 94276 Le Kremlin Bicêtre Cedex, France. christine.lacabaratz-porret@kb.u-psud.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Lacabaratz-Porret
authors.forename: Alejandra
authors.initials: A
authors.lastname: Urrutia
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Doisne
authors.forename: Cécile
authors.initials: C
authors.lastname: Goujard
authors.forename: Christiane
authors.initials: C
authors.lastname: Deveau
authors.forename: Marc
authors.initials: M
authors.lastname: Dalod
authors.forename: Laurence
authors.initials: L
authors.lastname: Meyer
authors.forename: Christine
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Alain
authors.initials: A
authors.lastname: Venet
authors.forename: Martine
authors.initials: M
authors.lastname: Sinet
mesh_terms: D000208:Acute Disease; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D019562:Viral Load