Cerebral neurogenesis is induced by intranasal administration of growth factors.
Neurogenesis persists in the adult brain, where it may contribute to repair and recovery after injury, but the lack of methods for noninvasive stimulation of cerebral neurogenesis limits its potential for clinical application. We report that intranasal administration of either fibroblast growth factor-2 or heparin-binding epidermal growth factor-like growth factor increases neurogenesis, measured by the incorporation of bromodeoxyuridine into cells that express the early neuronal marker protein doublecortin in the subventricular zone of mouse brain. These findings indicate that intranasal growth factors may have potential as neurogenesis-promoting therapeutic agents.
Jin
Kunlin
K
Buck Institute for Age Research, Novato, CA 94945, USA.
Xie
Lin
L
Childs
Jocelyn
J
Sun
Yunjuan
Y
Mao
Xiao Ou
XO
Logvinova
Anna
A
Greenberg
David A
DA
D000281:Administration, Intranasal; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000378:metabolism; D006133:Growth Substances / Q000008:administration & dosage* / Q000378:metabolism; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice
D006133:Growth Substances; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor