title: Family history of hypertension and type 2 diabetes in relation to preeclampsia risk.
abstract: In a case-control study of 190 preeclamptic patients and 373 control subjects, we assessed maternal family history of chronic hypertension and type 2 diabetes in relation to preeclampsia risk. Participants provided information on first-degree family history of the 2 conditions and other covariates during postpartum interviews. Logistic regression was used to estimate odds ratios and 95% confidence intervals adjusted for confounding by age, race, and obesity. Compared with women with no parental history of hypertension, women with maternal only (odds ratio=1.9), paternal only (odds ratio=1.8), or both maternal and paternal history of hypertension (odds ratio=2.6) had a statistically significant increased risk of preeclampsia. The odds ratio for women with at least one hypertensive parent and a hypertensive sibling was 4.7 (95% confidence interval, 1.9 to 11.6). Both maternal only (odds ratio=2.1; 95% confidence interval, 0.9 to 4.6) and paternal only (odds ratio=1.9; 95% confidence interval, 1.0 to 3.2) history of diabetes was associated with an increased risk of preeclampsia. Women with a diabetic sibling had a 4.7-fold increased risk of preeclampsia (95% confidence interval, 1.1 to 19.8). For women with at least one hypertensive parent and at least one diabetic parent, relative to those with parents with neither diagnosis, the odds ratio for preeclampsia was 3.2 (95% confidence interval, 1.6 to 6.2). Our results are consistent with the thesis that family history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased preeclampsia risk.
authors.affiliation: Center for Perinatal Studies, Swedish Medical Center, 747 Broadway, Suite 449 North Seattle, Wash 98122, USA. Chun-Fang.Qiu@Swedish.org
authors.forename: Chunfang
authors.initials: C
authors.lastname: Qiu
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Leisenring
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Sorensen
authors.forename: Ihunnaya O
authors.initials: IO
authors.lastname: Frederick
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Dempsey
authors.forename: David A
authors.initials: DA
authors.lastname: Luthy
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004198:Disease Susceptibility; D005192:Family Health; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D012307:Risk Factors