[Effects of Mycobacterium tuberculosis infection on the transcriptional expression of human macrophage gene encoding ion channels and related regulatory elements].
Expression microarray was employed in this study to investigate whether the ion channels and their regulatory elements encoding genes participate in the immune response to Mycobacterium tuberculosis infection. The results of a virulent strain were compared with those of the clinically isolated strains. The data demonstrate that K(+), Na(+), Ca(2+) and Cl(-) channels and their regulatory elements, such as the G protein, receptor and second messenger, protein kinase and protein phosphatase were involved in the immune reaction. The clinical strain affected more types of ion channels and respective regulatory elements. The data provides clues for further scrutiny into the role of ion channels and related elements in the interaction between Mycobacterium tuberculosis and host macrophage.
Xie
Jian-Ping
JP
State Key Laboratory of Genetic Engineering, Section of Pathogen Biology, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433.
Li
Yao
Y
Yue
Jun
J
Xu
Yong-Zhong
YZ
Liang
Li
L
Hu
Chang-Hua
CH
Yu
Shan-Qian
SQ
Wang
Hong-Hai
HH
D005786:Gene Expression Regulation; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D050436:Regulatory Elements, Transcriptional; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology
D007473:Ion Channels