title: The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine.
abstract: This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.
authors.affiliation: *†Department of Anesthesiology and Intensive Care, Hôpital de l'Hôtel-Dieu, Lyon; and ‡§Laboratory of Glycobiology, Unité INSERM 346, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Boselli
authors.forename: Frédéric
authors.initials: F
authors.lastname: Duflo
authors.forename: Richard
authors.initials: R
authors.lastname: Debon
authors.forename: Bernard
authors.initials: B
authors.lastname: Allaouchiche
authors.forename: Dominique
authors.initials: D
authors.lastname: Chassard
authors.forename: Luc
authors.initials: L
authors.lastname: Thomas
authors.forename: Jacques
authors.initials: J
authors.lastname: Portoukalian
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005434:Flow Cytometry; D006801:Humans; D019169:Jurkat Cells; D008012:Lidocaine / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000378:metabolism; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D010718:Phosphatidylserines; D000077212:Ropivacaine; D008012:Lidocaine