title: [Problems of functional study of the stomach in contemporary gastrology].
abstract: In the assessment of the functional state of the stomach the interest to its secretory functioning has remained constant and in the center of attention of physiologists and clinicians during the past century. That is understandable. After all, the level of secretion of gastric juice enriched with the acid and pepsins defines numerous aspects in the functioning of this organ and its peptic, bactericidal and even evacuation functions. Moreover, under certain conditions active gastric juice can turn from a mediator in the normal peptic process into a solely pathogenetic factor and promote the development of a number of so-called acid-dependent diseases that have conventionally included stomach ulcer, reflux-esophagitis, postgastrectomy ulcers of the anastomosis and other more infrequent pathological states. A distinct positive reaction to the application of anti-acid preparations is common for all these diseases. At the same time, the role of HCI in their development remains comprehensible only in some aspects.
authors.affiliation: Saint-Petersburg State Mechnikov Medical Academy.
authors.forename: V A
authors.initials: VA
authors.lastname: Gorshkov
mesh_terms: D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013270:Stomach / Q000382:microbiology / Q000502:physiology*