Genomic organization of ZP domain containing egg envelope genes in medaka (Oryzias latipes).
To provide insights into the diversity of egg envelope genes in teleosts, we determined the genomic organization and the map position of the medaka egg envelope genes expressed either in the oocytes or in the liver. There seems to be five classes of ZP domain containing egg envelope genes in vertebrates: zpa, zpax, zpb, zpc, and zpd. zpa, zpax, and zpb are much closely related than zpc. There is an expanded family of teleost-specific zpc genes. The duplication of the possible zpb/zpc cluster happened in the teleost lineage may be a cause of liver-specific ZP gene evolution in teleosts. The inconsistent presence of a repetitive amino acid domain among teleost zpb and zpc gene products suggests rapid evolution of this domain. In addition, relative abundance of E-boxes in putative promoters of medaka oocyte-specific ZP genes suggests their regulation by basic helix-loop-helix transcription factors, particularly by FIGalpha.
Kanamori
Akira
A
Laboratory of Molecular Genetics, Department of Biology, Nagoya University, Chikusa, Nagoya 464-8602, Japan. kanamori@bio.nagoya-u.ac.jp
Naruse
Kiyoshi
K
Mitani
Hiroshi
H
Shima
Akihiro
A
Hori
Hiroshi
H
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D002874:Chromosome Mapping; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004527:Egg Proteins / Q000235:genetics*; D005091:Exons; D005260:Female; D029941:Fish Proteins / Q000235:genetics*; D005796:Genes / Q000235:genetics; D007438:Introns; D008099:Liver / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D009865:Oocytes / Q000378:metabolism; D009990:Oryzias / Q000235:genetics*; D010802:Phylogeny; D011401:Promoter Regions, Genetic / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D015044:Zona Pellucida / Q000378:metabolism
D004527:Egg Proteins; D029941:Fish Proteins; D008562:Membrane Glycoproteins; D004247:DNA