Liposome recognition by resident and newly recruited murine liver macrophages.
The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement receptors no longer participate in liposome recognition and uptake.
Moghimi
S M
SM
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, BN2 4GJ, UK. s.m.moghimi@brighton.ac.uk
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D039481:CD11b Antigen / Q000096:biosynthesis; D004054:Diethylstilbestrol / Q000494:pharmacology; D007728:Kupffer Cells / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D009000:Monocytes / Q000378:metabolism
D018931:Antineoplastic Agents, Hormonal; D039481:CD11b Antigen; D008081:Liposomes; D004054:Diethylstilbestrol