Olanzapine treatment of anorexia nervosa: a retrospective study.
BACKGROUND
Recent reports raise the possibility that olanzapine, which commonly causes weight gain in non-eating-disordered subjects, assisted weight gain and mood during refeeding in anorexia nervosa (AN) patients.


METHODS
Eighteen AN subjects who engaged in open treatment with olanzapine were retrospectively questioned about their response.


RESULTS
Subjects reported a significant reduction in anxiety, difficulty eating, and core eating disorder symptoms after taking olanzapine.


CONCLUSIONS
These data lend support to the possibility that olanzapine may be useful in AN patients.


CONCLUSIONS
A controlled trial is necessary to prove that olanzapine is efficacious.
Malina
Amanda
A
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Gaskill
Jill
J
McConaha
Claire
C
Frank
Guido K
GK
LaVia
Maria
M
Scholar
Lisa
L
Kaye
Walter H
WH
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000188:drug therapy*; D001569:Benzodiazepines; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D011795:Surveys and Questionnaires
D001569:Benzodiazepines; D000077152:Olanzapine; D010890:Pirenzepine; D017367:Selective Serotonin Reuptake Inhibitors