Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission.
The present study was designed to assess whether the subtype of human immunodeficiency virus type 1 (HIV-1) could affect the rate of HIV-1 mother-to-child transmission in a cohort of 31 HIV-1-seropositive pregnant Tanzanian women. In order to assign a subtype to the samples analysed, nucleotide sequencing of the HIV-1 long terminal repeat U3 and C2V3C3 envelope regions was performed from the sera of these 31 pregnant women. Except in three cases, amplification of both regions was achieved in all samples. Subtypes A (n=13, 46 %), C (n=6, 21 %) and D (n=2, 7 %), as well as a number (25 %) of A/C, C/A, D/A and C/D recombinant forms (n=3, 2, 1 and 1, respectively), were identified. Of the 31 HIV-1 seropositive pregnant women analysed, eight (26 %) transmitted HIV-1 to their infants. Among the eight transmitter mothers, four (4 of 13, 31 %) were infected with HIV-1 subtype A, one (1 of 6, 17 %) with HIV-1 subtype C, none (0 of 2, 0 %) with HIV-1 subtype D and three (3 of 7, 43 %) with HIV-1 subtype recombinant A/C. These findings show no significant differences in the mother-to-child transmissibility of HIV-1 subtypes A, C and D and detected recombinants forms.
Tàpia
Natàlia
N
Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Franco
Sandra
S
Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
Puig-Basagoiti
Francesc
F
Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
Menéndez
Clara
C
Unitat d'Epidemiologia i Bioestadística, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
Alonso
Pedro Luis
PL
Unitat d'Epidemiologia i Bioestadística, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
Mshinda
Hassan
H
Ifakara Health Research and Development Centre, Ifakara, Tanzania.
Clotet
Bonaventura
B
Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Saiz
Juan Carlos
JC
Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
Martínez
Miguel Angel
MA
Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D016325:HIV Long Terminal Repeat; D006679:HIV Seropositivity / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000821:virology*; D012424:Rural Population; D013636:Tanzania; D014759:Viral Envelope Proteins / Q000235:genetics; D019562:Viral Load
D014759:Viral Envelope Proteins