[Changes in blood hormone levels in gout and methods of their correction (an experimental and clinical study)].
Gout belongs to often-occurring rheumatic pathologies and its incidence among the male population of Europe has been rapidly increasing during the recent years. The pathogenesis of the disease is insufficiently studied and the existing methods of pathogenetic therapy are low effective. The disease pathogenesis with regard for dishormonal disorders has been recently under discussion. 107 patients with primary gout and 70 white outbred male rats were examined. Disorders in the hypophysis-gonad system (i.e. hyperproduction of progesterone, and suppression of the synthesis of testosterone and estradiol, which are to a great extent typical for patients with chronic arthritis and with nephropathy of the proteinuric type) developed in men with gout. Similar changes were provoked experimentally by purine-exchange violations, which is indicative of their secondary nature. An exogenous administration of androgens at experimental hyperuricemy led to the normalization of purine exchange and of blood hormones, it also ensured an alleviation of pronounced morphological signs of arthritis. The application of testosterone and its analogues for people exceeds, by their effectiveness, the known treatment methods.
Mukhin
I V
IV
Ignatenko
G A
GA
D000728:Androgens / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D006073:Gout / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats
D000728:Androgens; D000893:Anti-Inflammatory Agents; D012739:Gonadal Steroid Hormones; D006062:Gonadotropins