title: Adjuvant activity of alum in inducing antigen specific IgE antibodies in BALB/c mice: a reevaluation.
abstract: The IgE production was compared in the presence and absence of aluminum hydroxide gel (alum). Without alum, the IgE production was induced within a suitable range of the antigen dosage; however, alum enhanced it. Alum did not affect the minimum requirement for the antigen dosage, indicating that alum may not take part in the efficiency of antigen presentation.
authors.affiliation: Department of Nutrition, School of Medicine, University of Tokushima, Kuramoto-cho 3-18-15, Tokushima-shi, Tokushima 770-8503, Japan. rintaro@nutr.med.tokushima-u.ac.jp
authors.forename: Rintaro
authors.initials: R
authors.lastname: Yamanishi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Yusa
authors.forename: Noriko
authors.initials: N
authors.lastname: Bando
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000276:Adjuvants, Immunologic; D000534:Alum Compounds / Q000494:pharmacology*; D000818:Animals; D000918:Antibody Specificity; D004797:Enzyme-Linked Immunosorbent Assay; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis
chemical_list: D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D007074:Immunoglobulin G; C041524:aluminum sulfate; D007073:Immunoglobulin E; D010047:Ovalbumin