title: Hemodynamic response of the left gastric vein to glucagon in patients with portal hypertension and esophageal varices.
abstract: Flow direction and flow velocity of the left gastric vein (LGV) and the portal vein (PV) were examined by a Doppler sonographic machine in 33 patients with esophageal varices, before and after venous injection of glucagon (1 mg). In two patients with hepatopetal blood flow in the LGV, the flow direction changed to hepatofugal after injection of glucagon. In 31 patients with hepatofugal blood flow in the LGV, a significant increase of flow velocity was observed in the LGV in 18 patients (58.1%) and the changes (26.4 +/- 24.6%) were significantly larger than those in the PV (7.9 +/- 16.0%). The changes in flow velocity decreased in the LGV as the diameter of the LGV and the size of varices increased. In conclusion, glucagon increased collateral blood flow in the LGV in portal hypertension. However, the grade of the response decreased as the grade of portal hypertension increased.
authors.affiliation: The Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan. matsu@med.m.chiba-u.ac.jp
authors.forename: Shoichi
authors.initials: S
authors.lastname: Matsutani
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Goro
authors.initials: G
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukuzawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mizumoto
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Saisho
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003097:Collateral Circulation / Q000187:drug effects; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000187:drug effects; D018709:Statistics, Nonparametric; D013270:Stomach / Q000098:blood supply*; D018608:Ultrasonography, Doppler; D014665:Vasodilator Agents / Q000494:pharmacology*; D014680:Veins / Q000000981:diagnostic imaging / Q000187:drug effects
chemical_list: D014665:Vasodilator Agents; D005934:Glucagon