title: [Adverse effects of dichloroacetate in a girl with mitochondrial disorder].
abstract: We present the effects and adverse effects of dichloroacetate (DCA) in a girl with mitochondrial disorder. Oral administration of DCA 50 mg/kg per day, reduced the elevated levels of lactate to below the normal range. Treatment with DCA ameliorated electroencephalogram abnormalities, but caused the adverse effects with hepatomegaly and decreased activity, which were improved by reduction or withdrawal of DCA. The decreased activity may be an adverse effect on the central nervous system. The dosage of DCA should be adjusted for each patient.
authors.affiliation: Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo.
authors.forename: Mina
authors.initials: M
authors.lastname: Izumi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Michio
authors.initials: M
authors.lastname: Fukumizu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hanaoka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Kaga
authors.forename: Keiko
authors.initials: K
authors.lastname: Murayama
mesh_terms: D000284:Administration, Oral; D002490:Central Nervous System / Q000187:drug effects; D002675:Child, Preschool; D003999:Dichloroacetic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D018476:Hypokinesia / Q000139:chemically induced; D019344:Lactic Acid / Q000097:blood; D028361:Mitochondrial Diseases / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D019344:Lactic Acid; D003999:Dichloroacetic Acid