title: Simplakidine A, a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex.
abstract: Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Dipartimento di Farmacologia Sperimentale, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Campagnuolo
authors.forename: Caterina
authors.initials: C
authors.lastname: Fattorusso
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Angela
authors.initials: A
authors.lastname: Ianaro
authors.forename: Barbara
authors.initials: B
authors.lastname: Pisano
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
chemical_list: D000470:Alkaloids; D011726:Pyridinium Compounds; C474590:simplakidine A