title: [1,1, 1-trichloroethane-induced chronic active hepatitis].
abstract: 1,1, 1-trichloroéthane is derived from carbon tetrachloride and has been widely used as an industrial solvent since 1954, because of its supposed lack of toxicity. However, several cases of central nervous system toxicity and heart disorders due to intoxication by 1,1, 1-trichloroéthane have been reported. Cases of liver injury are infrequent, with less than 10 cases, unlike 1,1, 2-trichloroéthane that it replaced. We report a case of hepatotoxicity probably due to 1,1, 1-trichloroéthane exposure, characterized by an original pathologic feature of chronic active hepatitis.
authors.affiliation: Service d'Hépato-Gastroentérologie, CHU, 49033 Angers Cedex 01.
authors.forename: Vincent
authors.initials: V
authors.lastname: Croquet
authors.forename: Joël
authors.initials: J
authors.lastname: Fort
authors.forename: Frédéric
authors.initials: F
authors.lastname: Oberti
authors.forename: Yves
authors.initials: Y
authors.lastname: Roquelaure
authors.forename: Abdel Kader
authors.initials: AK
authors.lastname: Ben Bouali
authors.forename: Christophe
authors.initials: C
authors.lastname: Pilette
authors.forename: Paul
authors.initials: P
authors.lastname: Calès
mesh_terms: D000328:Adult; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D012997:Solvents / Q000506:poisoning*; D013997:Time Factors; D014240:Trichloroethanes / Q000506:poisoning*
chemical_list: D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane