title: In vivo multiple-mouse imaging at 1.5 T.
abstract: A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 microm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner.
authors.affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: T P F
authors.initials: TP
authors.lastname: Gade
authors.forename: C
authors.initials: C
authors.lastname: Matei
authors.forename: K
authors.initials: K
authors.lastname: Zakian
authors.forename: A A
authors.initials: AA
authors.lastname: Alfieri
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: E C
authors.initials: EC
authors.lastname: Holland
authors.forename: S
authors.initials: S
authors.lastname: Soghomonian
authors.forename: J
authors.initials: J
authors.lastname: Tjuvajev
authors.forename: D
authors.initials: D
authors.lastname: Ballon
authors.forename: J A
authors.initials: JA
authors.lastname: Koutcher
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D018827:Carcinoma, Lewis Lung / Q000175:diagnosis; D004867:Equipment Design; D005240:Feasibility Studies; D005910:Glioma / Q000175:diagnosis; D008175:Lung Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal