Distribution of HLA-B alleles in Mexican Amerindian populations.
In the present study we analyzed by PCR-SSO technique the HLA-B gene frequencies in 281 healthy individuals from four Mexican Amerindian populations (66 Mayos, 90 Mazatecans, 72 Nahuas and 53 Teenek). The most frequent alleles in all studied populations were HLA-B35, HLA-B39, and HLA-B40; however, some differences were observed between populations. The HLA-B35 allele was the most frequent in three of the four populations studied (Mayos, Nahuas and Teenek), whereas in Mazatecans the most frequent allele was HLA-B39. HLA-B40 presented frequencies higher than 10% in all groups. On the other hand, only Mayos presented an HLA-B51 gene frequency higher than 10%. When comparisons were made, important differences between groups were observed. The Teenek group presented an increased frequency of HLA-B35 when compared to Mazatecans and the HLA-B52 allele was increased in Nahuas and Teenek when compared to Mayos. An increased frequency of HLA-B39 was observed in Mazatecans when compared to Nahuas, Mayos and Teenek. Also, an increased frequency of HLA-B51 was observed in Mayos when compared to Mazatecans and Nahuas. These data corroborate the restricted polymorphism of HLA-B alleles and the high frequency of HLA-B35, HLA-B39 and HLA-B40 alleles in autochthonous American populations. In spite of the restriction in this polymorphism, differences in frequencies of HLA-B alleles could be helpful in distinguishing each of these populations.
Vargas-Alarcón
Gilberto
G
Physiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. gvargas63@yahoo.com
Hernández-Pacheco
Guadalupe
G
Zuñiga
Joaquín
J
Rodríguez-Pérez
José Manuel
JM
Pérez-Hernández
Nonanzit
N
Rangel
Carlos
C
Villarreal-Garza
Cynthia
C
Martínez-Laso
Jorge
J
Granados
Julio
J
Arnaiz-Villena
Antonio
A
D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D016133:Polymerase Chain Reaction
D015235:HLA-B Antigens