title: [Progress on Y chromosome microdeletions and male infertility].
abstract: About 10%-15% of azoospermic and 5%-10% of severely oligozoospermic men with idiopathic infertility have Yq microdeletions which could be transmitted to their male offspring by means of ICSI. We review present studies about Yq microdeletions including incidence, region, correlations between genotype and phenotype, the mechanism of Yq deletions and try to further understand the cause of male infertility as well as provide a new way for diagnosis and therapy.
authors.affiliation: Reproductive Medicine Center, Peking University Third Medical School, Beijing 100083, China.
authors.forename: Gui-Mei
authors.initials: GM
authors.lastname: Yao
authors.forename: Gui-An
authors.initials: GA
authors.lastname: Chen
mesh_terms: D002872:Chromosome Deletion; D002874:Chromosome Mapping; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D012729:Sex Chromosome Aberrations