title: [Noninvasive monitoring of chronic glomerulonephritides progression].
abstract: Progression to end-stage renal failure is the final common pathway of many forms of glomerular diseases, independent of the type of initial insult. Tubulointerstitial fibrosis is tis near invariable finding and significant prognostic feature. We have reviewed immunological (cytokines, inflammatory cells) and nonimmunological factors (extracellular matrix proteins and proteolytic enzymes), being involved in mechanisms leading from glomerular disease to tubulointerstitial scarring, from the point of view of potential clinical usefulness of measuring its urine activities and levels to noninvasive diagnostic of kidney diseases.
authors.affiliation: Klinika Immunologii, Transplantologii i Chorób Wewnetrznych Instytutu Transplantologii Akademii Medycznej w Warszawie.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Senatorski
authors.forename: Leszek
authors.initials: L
authors.lastname: Paczek
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kropiewnicka
authors.forename: Janusz
authors.initials: J
authors.lastname: Wyzgał
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pilecki
authors.forename: Jolanta
authors.initials: J
authors.lastname: Zegarska
authors.forename: Monika
authors.initials: M
authors.lastname: Niewczas
mesh_terms: D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005355:Fibrosis / Q000378:metabolism; D005921:Glomerulonephritis / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D009395:Nephritis, Interstitial / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016207:Cytokines; D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D010447:Peptide Hydrolases