Anti-endothelial cell reactivity, the unresolved enigma.
Not only are some anti-endothelial cell antibodies (AECA) directed to thus far unidentified cell membrane structures, but some ot them recognize "planted" antigens and possibly ligand-receptor complexes. The functional heterogeneity of AECA is widely acknowledged: part of them activate the complement, mediate antibody-dependent cell cytotoxicity of trigger the production of tissue procoagulant factor. It has also recently been established that a proportion of AECA have the capacity to induce apoptosis of their target cells. In fact, the most direct demonstration of the pathogenicity of AECA is the autoantibody-induced murine model of vasculitis.
Castillo
S
S
Lab. of Immunology, Brest University Medical School, Brest, France.
Revelen
R
R
Bordron
A
A
Renaudineau
Y
Y
Dueymes
M
M
Youinou
P
P