Relationship between serum N-carbamoyl-beta-D-glucopyranosylamine level and renal failure.
A statistical investigation was carried out on the distribution of serum N-carbamoyl-beta-D-glucopyranosylamine (NCG) among various patient groups. The serum NCG levels of patients treated in the departments of hemodialysis (131 +/- microM), nephritic syndrome (47 +/- 54 microM), and diabetes mellitus (55 +/- 70 microM) were significantly higher (p < 0.01) than those in other internal disease patients (18 +/- 22 microM) and healthy volunteers (6 +/- 22 microM). The serum NCG level was greatly reduced by hemodialysis therapy, however a return to initial NCG levels was observed within about one week. These results indicate that a high serum NCG level is a feature of renal failure patients, and a relationship was demonstrated between hyperuremia and NCG formation and accumulation in blood.
Hamafuji
Tetsuro
T
Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. hamafuji@irc-net.co.jp
Tsugawa
Wakako
W
Sode
Koji
K
D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005944:Glucosamine / Q000031:analogs & derivatives / Q000097:blood*; D006801:Humans; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000628:therapy; D013577:Syndrome
D015415:Biomarkers; C023429:antibiotic SF 1933; D005944:Glucosamine