title: Pentoxifylline in the treatment of erythema nodosum leprosum.
abstract: Erythema nodosum leprosum (ENL) is a well-known serious complication affecting 10% of lepromatous multibacillary leprosy patients. In the chronic form, its morbidity may be considerable. Thalidomide and systemic steroids are the two current effective drugs for the management of ENL. However, their use in endemic countries is often difficult and hazardous, and a search for new therapies is needed. We report our experience on the effects of pentoxifylline, a methylxanthine derivative, which has recently been suggested as a possible effective treatment for ENL attacks.
authors.affiliation: Dispensaire de Mamoudzou, DASS de Mayotte, BP 104, 97600, Mamoudzou, Mayotte, France.
authors.forename: Georges-Yves
authors.initials: GY
authors.lastname: De Carsalade
authors.forename: Aboubacar
authors.initials: A
authors.lastname: Achirafi
authors.forename: Béatrice
authors.initials: B
authors.lastname: Flageul
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D004893:Erythema Nodosum / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010431:Pentoxifylline / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D007917:Leprostatic Agents; D010431:Pentoxifylline