[Effects of lead on NO, NOS, SOD, MDA in rat cerebral cortex].
To study the effects of lead exposure on nitric oxide (NO), nitric oxide synthase (NOS), super oxide dismutase (SOD) and malondialdehyde (MDA) in cerebral cortex of rats, Wistar rats are exposed to lead from drinking 0, 18.4, 184 mg/L lead acetate solution respectively.


RESULTS
Cerebral cortex NOS activity in low and high-dosed lead exposure groups are significantly increased at the time of 7 days (P < 0.05), cerebral cortex NOS activity in low-dosed group is significantly decreased after 90 days and 30 days in high-dosed group (P < 0.05) as compared with that of the controls. Cerebral cortex NO content is markedly decreased in low-dosed group after 90 days poisoning and 14 days, 60 days, 90 days in high-dosed group (P < 0.05). SOD activity in low and high-dosed group is significantly decreased after 30 days exposure. MDA content is markedly increased after 14 days exposure in high-dosed group.


CONCLUSIONS
It is suggested that the damage of cerebral cortex may caused by lead toxicity that results from the changes of NOS activity, NO level, SOD activity and MDA content in cerebral cortex.
Wang
Shixin
S
Medical College of Chinese People's Armed Police Force, Tianjin 300162, China.
Zhou
Wei
W
Wei
Maoti
M
Zhang
Guohui
G
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D007854:Lead / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D007854:Lead; D009569:Nitric Oxide; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase