title: Cyclic recovery of adenovirus in a stem cell transplant recipient: an inverse association with graft-versus-host disease.
abstract: Adenovirus (AdV) infections have been increasingly recognized as significant pathogens that may cause severe morbidity and mortality among stem cell transplant (SCT) recipients. AdV can cause localized infections such as hemorrhagic cystitis (HC), pneumonia, hepatitis and also disseminated disease that can lead to death. We report a case of severe hemorrhagic cystitis in a SCT recipient who died 83 days after transplant. In this patient, AdV recovery was not constantly detected. In fact, fluctuations of the AdV detection in leukocytes and urine were observed by culture and PCR. When analyzing this viral cyclic recovery with different signs or symptoms in the patient, we observed an inverse association with the presence of acute graft-versus-host disease (GVHD). Whether these fluctuations represent donor-derived reactivity, indirectly manifested by the presence of GVHD, requires further study. This is the first case describing a dynamic pattern of AdV replication in leukocytes and urine samples from a patient with severe HC and the temporal correlation with GVHD.
authors.affiliation: Virology Division, Centro de Educacción Médica e Investigaciones Clínicax, Galvan, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Echavarria
authors.forename: F
authors.initials: F
authors.lastname: Herrera
authors.forename: J
authors.initials: J
authors.lastname: Solimano
authors.forename: L
authors.initials: L
authors.lastname: Villamea
authors.forename: L
authors.initials: L
authors.lastname: Riera
authors.forename: E P A
authors.initials: EP
authors.lastname: de Klerk
authors.forename: A C M
authors.initials: AC
authors.lastname: Kroes
authors.forename: G
authors.initials: G
authors.lastname: Carballal
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics / Q000302:isolation & purification*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D016133:Polymerase Chain Reaction; D033581:Stem Cell Transplantation; D013997:Time Factors