title: Pain resolution after lumbar disc surgery is influenced by macrophage tissue infiltration. A prospective consecutive study on 177 patients.
abstract: The aim of this study was to assess the influence of inflammatory reactions in herniated lumbar disc specimens on pain resolution after lumbar disc surgery. Disc specimens of 200 patients who underwent surgery for lumbar disc herniation were studied immunohistologically. Preoperatively each patient received a verbal rating scale (VRS) for classification of the pain level and general clinical data were recorded prospectively. Varying amounts of macrophages could be demonstrated. Eighty-nine percent of patients could be followed up for a mean period of 7 months. A statistically significant correlation between the histologically observed macrophage infiltration and postoperative pain grading according to the VRS was found. Patients with evidence of inflammatory reactions rated their postoperative complaints lower than patients with no evidence of inflammatory reactions on the VRS (P = 0.04). In our study, a statistically significant correlation between inflammatory changes in the herniated lumbar disc specimen and outcome after lumbar disc surgery could be demonstrated.
authors.affiliation: Department of Neurosurgery, University of Regensburg, Germany. rolf.rothoerl@klnink.uni-regensburg.de
authors.forename: Ralf Dirk
authors.initials: RD
authors.lastname: Rothoerl
authors.forename: Chris
authors.initials: C
authors.lastname: Woertgen
authors.forename: Alexander
authors.initials: A
authors.lastname: Brawanski
mesh_terms: D000328:Adult; D000368:Aged; D015299:Discitis / Q000276:immunology / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007405:Intervertebral Disc Displacement / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D011300:Preoperative Care; D011446:Prospective Studies; D016896:Treatment Outcome