title: [Chlamydia pneumoniae antibodies and other atherosclerosis risk factors in haemodialysed patients. Preliminary report].
abstract: Nowadays, it is considered that viral or bacterial infections can influence atherosclerosis development rate. One of them is infection by Chlamydia pneumoniae. The aim of the study was to assess the occurrence of anti-Chlamydia pneumoniae antibodies (AChPA) and their relationship with biochemical and clinical atherosclerosis risk factors in haemodialysed patients. There were 38 patients (24M, 14F) at the mean age 63.3 +/- 14.5 years, haemodialysed for 30.9 +/- 26.1 months. Previous Ch. Pneumoniae infection was assessed based on AchPA IgA and IgG concentrations determined using SIMPLE INDEX. The following risk factors for atherosclerosis were checked in the study group: total cholesterol. CRP and iPTH. AChPA indicative for Ch. pneumoniae infection in the past were detected in 28 patients (74%). The study group was divided into two subgroups; A- (n = 28 patients) with serological features of previous Ch. pneumoniae infection and B- (n = 10 patients) without serological features of Ch. pneumoniae infection. We found no statistical difference between the groups in the studied biochemical factors. We found no correlation between AChPA and other atherosclerosis risk factors. Our preliminary report does not confirm the prognostic value of AChPA presence as an atherosclerosis risk factor in haemodialysed patients.
authors.affiliation: Klinika Nefrologii ze Stacja Dializ Centralnego Szpitala Klinicznego WAM.
authors.forename: Monika
authors.initials: M
authors.lastname: Prokopiuk
authors.forename: Przemysław
authors.initials: P
authors.lastname: Wierzbicki
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kade
authors.forename: Sławomir
authors.initials: S
authors.lastname: Dudko
authors.forename: Zofia
authors.initials: Z
authors.lastname: Wańkowicz
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D023521:Chlamydophila Infections / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D003324:Coronary Artery Disease / Q000276:immunology / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G