title: Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress?
abstract: BACKGROUND
  Life events (LE) have consistently been found to influence course and outcome of psychotic disorders. However, the mechanism through which they operate is not known. The present study investigated whether LE have their effect by impacting on the emotional sensitivity for daily hassles.
  
  
  METHODS
  Patients with clinically remitted psychotic illness (N=42) were studied with the Experience Sampling Method (a structured diary technique assessing current context and mood in daily life) to assess: (1) appraised subjective stress related to daily events and activities; and (2) emotional reactivity conceptualized as changes in both negative affect (NA) and positive affect (PA). LE were assessed with the Brown & Harris Life Event and Difficulties Schedule.
  
  
  RESULTS
  Multilevel regression analyses showed that previous exposure to LE influenced the appraised stressfulness of neither daily events nor the activities in which the subjects were involved. However, a history of LE did modify the emotional reaction to daily life stress, both in models predicting NA and in models predicting PA.
  
  
  CONCLUSIONS
  By their cumulative effect on emotional reactivity to daily activities and events, LE may render individuals more vulnerable to the onset or persistence of psychotic experiences.
authors.affiliation: Department of Psychiatry and Neuropsychology, azM/Riagg/Vijverdal Academic Centre, Maastricht University, The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Myin-Germeys
authors.forename: L
authors.initials: L
authors.lastname: Krabbendam
authors.forename: P A E G
authors.initials: PA
authors.lastname: Delespaul
authors.forename: J
authors.initials: J
authors.lastname: Van Os
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology* / Q000523:psychology; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000523:psychology; D012044:Regression Analysis; D013315:Stress, Psychological / Q000453:epidemiology* / Q000523:psychology