New briaranes from the Taiwanese gorgonian Junceella juncea.
In addition to the known junceelolide C (4), three new briaranes, juncenolides B (1), C (2), and D (3), have been isolated from the acetone extract of a red Gorgonian Junceella juncea collected in Taiwan. The structures of 1-3 were elucidated on the basis of FABMS and 2D NMR techniques including COSY, HMQC, HMBC, and NOESY experiments. Among them, compound 2 exhibited mild cytotoxicity against human liver carcinoma (HEPA 59T/VGH) and oral epidermoid (KB) carcinoma cells.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Lin
Yu-Chi
YC
Ko
Chin-Lien
CL
Wang
Li-Tang
LT
D000818:Animals; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019156:Indian Ocean; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008113:Liver Neoplasms; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004224:Diterpenes; D007783:Lactones; C475232:junceelolide C