Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4.
We report the expression of zebrafish lmo4 during the first 48 h of development. Like its murine ortholog, lmo4 is expressed in somitic mesoderm, branchial arches, otic vesicles, and limb (pectoral fin) buds. In addition, however, we report zebrafish lmo4 expression in the developing eye, cardiovascular tissue, and the neural plate and telencephalon. We demonstrate that expression in the rostral hindbrain requires acerebellar (ace/fgf8) and spiel ohne grenzen (spg/pou2) activity.
Lane
Mary Ellen
ME
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street/LRB822, Worcester, MA 01605, USA. melane@rice.edu
Runko
Alexander P
AP
Roy
Nicole M
NM
Sagerström
Charles G
CG
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D005775:Gastrula / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D060588:LIM Domain Proteins; D051379:Mice; D008969:Molecular Sequence Data; D050814:Octamer Transcription Factor-3; D009928:Organ Specificity; D010802:Phylogeny; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D015027:Zebrafish / Q000235:genetics*; D029961:Zebrafish Proteins
D048868:Adaptor Proteins, Signal Transducing; D018398:Homeodomain Proteins; D060588:LIM Domain Proteins; C491976:Lmo4 protein, mouse; D050814:Octamer Transcription Factor-3; C085437:Pou5f3 protein, zebrafish; D014157:Transcription Factors; D029961:Zebrafish Proteins; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors