Comorbidity of schizophrenia and galactosemia: effective clozapine treatment with weight gain.
Weight gain with atypical antipsychotics such as clozapine has been hypothesized to have a multifactorial genesis. Beside changes in neurotransmitter systems caused by antipsychotic-induced receptor blockade, hormonal changes and other neuroleptic side-effects (sedation, reduced activity, reduced basal metabolic rate, dry mouth) are also discussed. Our unique case report of a patient with comorbid galactosemia and schizophrenia is an interesting example of weight gain being a positive side-effect of clozapine, not necessarily associated with increased appetite and higher caloric intake.
Haasen
Christian
C
Department of Psychiary and Psychotherapy, University-Hospital Eppendorf, Hamburg, Germany. haasen@uke.uni-hamburg.de
Lambert
Martin
M
Yagdiran
Oktay
O
Karow
Anne
A
Krausz
Michael
M
Naber
Dieter
D
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D005693:Galactosemias / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015430:Weight Gain
D014150:Antipsychotic Agents; D003024:Clozapine