[Metabolism of neuroactive amino acids in the rat cerebral cortex during morphine intoxication].
The effect of acute and chronic morphine intoxication on the content of aspartate, glutamate, glutamine, glycine, and GABA in rat brain was studied. Under the acute intoxication conditions, the most pronounced changes were observed for a morphine dose of 10 mg/kg (b.w.) and manifested by prevailing excitation processes in this part of CNS. On the contrary, the chronic introduction of morphine led to an increase in the content of inhibitory amino acids.
Kurbat
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MN
Department of Biochemistry, Grodno State Medical University, ul. M. Gor'kogo 80, Grodno, 230015 Belarus.
Lelevich
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VV
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000506:poisoning*; D009294:Narcotics / Q000506:poisoning*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011041:Poisoning / Q000378:metabolism; D051381:Rats
D009294:Narcotics; D018377:Neurotransmitter Agents; D009020:Morphine