Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions.
Papaverine hydrochloride, papaverinol, and papaveraldine chloroform solutions were exposed to UV light of 254 nm in atmospheric, aerobic and anaerobic (helium) conditions. The same degradation products appear (TLC) in the above papaverine hydrochloride chloroform solutions. However, the rate of papaverine hydrochloride degradation processes is enhanced as a function of oxygen pressure. Papaverinol and papaveraldine photooxidation products are essentially not different from those observed in the above papaverine hydrochloride solutions. However, the amount of an unknown brown degradation product (X) is the greatest in the papaverinol chloroform solution degraded. That brown compound was previously observed in papaverine either hydrochloride or sulfate injection solutions on their storage even when protected from daylight. The preliminary X product structure development was undertaken (TLC, molecular weight, elemental analysis, UV/VIS, IR and 13C MAS NMR spectroscopy).
Piotrowska
Karolina
K
Department of Physical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Swiecickiego Str., 60-781 Poznań, Poland.
Hermann
Tadeusz W
TW
Augustyniak
Włodzimierz
W
D002725:Chloroform / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D010084:Oxidation-Reduction; D010208:Papaverine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D019999:Pharmaceutical Solutions / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D019999:Pharmaceutical Solutions; C039657:papaverinol; D002725:Chloroform; D010208:Papaverine; C039655:papaveraldine