title: Role of sublingual misoprostol for cervical ripening prior to vacuum aspiration in first trimester interruption of pregnancy.
abstract: This is a prospective randomized clinical trial evaluating, for the first time, the effectiveness of sublingual route of misoprostol for cervical priming prior to vacuum aspiration (VA). The trial included 100 women seeking first trimester abortion who were sequentially randomized into two groups of 50 each. Patients of study group received 400 microg sublingual misoprostol 3 h prior to VA while those of the control group did not receive any premedication for cervical ripening. For all periods of gestation between 6 and 12 weeks, misoprostol significantly reduced pain score, blood loss, time duration and rate of complications without increasing the side effects. Sublingual misoprostol is an effective alternative to mechanical cervical dilatation. It can be self-administered and has a good patient-acceptability rate. As no study has evaluated the role of sublingual route of misoprostol for cervical priming before VA, wider studies should be done to advocate its routine use.
authors.affiliation: Department of Obstetrics and Gynecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India. pikeesaxena@hotmail.com
authors.forename: Pikee
authors.initials: P
authors.lastname: Saxena
authors.forename: Sudha
authors.initials: S
authors.lastname: Salhan
authors.forename: Nivedita
authors.initials: N
authors.lastname: Sarda
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000286:Administration, Sublingual; D000328:Adult; D016022:Case-Control Studies; D020070:Cervical Ripening / Q000187:drug effects*; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D014619:Vacuum Curettage / Q000379:methods*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol