HPFP, a model propellant for pMDIs.
A novel model propellant for the study of the properties of pMDIs (pressurized metered-dose inhalers) at atmospheric pressure is proposed and extensively characterized. The reasons for the choice of this liquid, with its advantages and drawbacks, are explained and justified. Comparison with existing fluorinated propellants is also documented.
Rogueda
Philippe G A
PG
Pharmaceutical and Analytical Research & Development, AstraZeneca R&D Charnwood, Loughborough, UK. philippe.rogueda@astrazeneca.com
D000335:Aerosol Propellants / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003720:Densitometry; D005079:Excipients / Q000737:chemistry; D005466:Fluorocarbons / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D036501:Metered Dose Inhalers; D012031:Refractometry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013500:Surface Tension; D014867:Water / Q000737:chemistry; D010420:Pentanes
D000335:Aerosol Propellants; D005079:Excipients; D005466:Fluorocarbons; D006845:Hydrocarbons, Fluorinated; D014867:Water; C008806:perfluoropentane; D010420:Pentanes; C094049:apaflurane