title: tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila.
abstract: We cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. The tinc mRNA was expressed specifically in four of the six pairs of cardioblasts in each segment, in a pattern identical to that of tinman (tin), a homeobox gene required for the specification of the dorsal vessel. In the non-Tin-expressing pairs of cardioblasts, tinc transcription seemed to be repressed by Seven-up.
authors.affiliation: Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirota
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sawamoto
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Okano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D032386:Myoblasts, Cardiac / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D011987:Receptors, Steroid; D012097:Repressor Proteins; D015534:Trans-Activators; C094295:svp protein, Drosophila; C102933:tin protein, Drosophila; C472859:tinc protein, Drosophila