Primary 1-arylcyclopropylamines from aryl cyanides with diethylzinc and titanium alkoxides.
1-Aryl-substituted primary cyclopropylamines are conveniently prepared from aromatic nitriles and diethylzinc. The yields range from 40 to 56% for donor-substituted (five examples) to 62-82% for non- and acceptor-substituted substrates (nine examples).
Wiedemann
Stefan
S
Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany.
Frank
Daniel
D
Winsel
Harald
H
De Meijere
Armin
A