title: Anti-endothelial cell reactivity, the unresolved enigma.
abstract: Not only are some anti-endothelial cell antibodies (AECA) directed to thus far unidentified cell membrane structures, but some ot them recognize "planted" antigens and possibly ligand-receptor complexes. The functional heterogeneity of AECA is widely acknowledged: part of them activate the complement, mediate antibody-dependent cell cytotoxicity of trigger the production of tissue procoagulant factor. It has also recently been established that a proportion of AECA have the capacity to induce apoptosis of their target cells. In fact, the most direct demonstration of the pathogenicity of AECA is the autoantibody-induced murine model of vasculitis.
authors.affiliation: Lab. of Immunology, Brest University Medical School, Brest, France.
authors.forename: S
authors.initials: S
authors.lastname: Castillo
authors.forename: R
authors.initials: R
authors.lastname: Revelen
authors.forename: A
authors.initials: A
authors.lastname: Bordron
authors.forename: Y
authors.initials: Y
authors.lastname: Renaudineau
authors.forename: M
authors.initials: M
authors.lastname: Dueymes
authors.forename: P
authors.initials: P
authors.lastname: Youinou