Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols.
Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl(2) and a catalytic amount of NiCl(2) and triphenylphosphine in the presence of water in DMF at 25 degrees C gives a 1,2-disubstituted allylic alcohol regioselectively.
Takai
Kazuhiko
K
Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan. ktakai@cc.okayama-u.ac.jp
Sakamoto
Shuji
S
Isshiki
Takahiko
T