title: MR imaging at rest early after myocardial infarction: detection of preserved function in regions with evidence for ischemic injury and non-transmural myocardial infarction.
abstract: Patients with subacute myocardial infarction were studied to detect regions of ischemic injury but with preserved myocardial function combining different MRI techniques. On a 1.5-T imaging system 27 patients were examined 7-14 days after acute myocardial infarction. The imaging protocol included T2-weighted fast spin-echo imaging, a cine fast low-angle shot (FLASH) 2D technique to determine regional function at rest, and a first pass as well as late contrast enhancement perfusion study injecting 0.1 mmol/kg Gd-DTPA. Preserved function was compared with the transmural extent of first-pass perfusion phenomena, increased T2 signal intensity (SI), and late contrast enhancement. Semi-quantitative first-pass perfusion parameters were correlated with quantitative myocardial wall thickening (MWT) and degree of coronary artery stenosis. Indicating ischemic injury increased T2 SI and late enhancement was present in 29 and 26% of segments. Preserved function was found predominantly in segments with non-transmural late enhancement (112 of 338 segments with late enhancement) and transmural increase of T2 SI (129 of 386 segments with increased T2 SI). A high-grade perfusion deficit was detected in 4% of all segments and regularly associated with markedly decreased systolic function. Correlation of first-pass perfusion parameters was observed with MWT (r=0.50-0.90, p<0.001) but not with the degree of coronary artery stenosis. Our data suggest that preserved function was detected in non-transmural myocardial infarction demonstrated by non-transmural late enhancement and increase of T2 SI.
authors.affiliation: Department of Diagnostic Radiology, Eberhards Karls University, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany. stephan.miller@uni-tuebingen.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Miller
authors.forename: Uwe
authors.initials: U
authors.lastname: Helber
authors.forename: Klaus
authors.initials: K
authors.lastname: Brechtel
authors.forename: Thomas
authors.initials: T
authors.lastname: Nägele
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hahn
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kramer
authors.forename: Hans M
authors.initials: HM
authors.lastname: Hoffmeister
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D015331:Cohort Studies; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006334:Heart Function Tests; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging / Q000473:pathology; D015588:Observer Variation; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D011859:Radiography; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA