title: Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major.
abstract: Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Colby
authors.initials: C
authors.lastname: Zaph
authors.forename: Phillip
authors.initials: P
authors.lastname: Scott
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D054357:Chemokine CXCL10; D018925:Chemokines / Q000235:genetics*; D019743:Chemokines, CXC / Q000235:genetics; D005786:Gene Expression Regulation; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000502:physiology*; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H
chemical_list: D001426:Bacterial Proteins; D054357:Chemokine CXCL10; D018925:Chemokines; D019743:Chemokines, CXC; D008565:Membrane Proteins; D018664:Interleukin-12; D007371:Interferon-gamma