title: Observations on the early results of treatment of recurrent respiratory papillomatosis using cidofovir.
abstract: OBJECTIVE
  To document the response of two patients with severe recurrent laryngeal papillomatosis following treatment with intralesional cidofovir in conjunction with carbon-dioxide laser evaporation.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  Retrospective review of treatment of two patients followed up over a 12-month period.
  
  
  METHODS
  Microlaryngoscopy and carbon-dioxide laser evaporation of lesions followed by intralesional injection of cidofovir.
  
  
  METHODS
  Photodocumentation and descriptive statistical representation of intervals between endoscopic treatment. The disease was staged according to severity on endoscopy.
  
  
  RESULTS
  Initially, both patients showed a marked improvement of disease. However, the disease relapsed to a significant extent. Overall, there was no demonstrable change in the frequency of required endoscopies despite subjective improvement of the airway.
  
  
  CONCLUSIONS
  Cidofovir may be of some benefit in the management of recurrent respiratory papillomatosis, but further studies are still required.
authors.affiliation: Department of Otolaryngology, The Hospital for Sick Children, Toronto, Ontario.
authors.forename: H
authors.initials: H
authors.lastname: El Hakim
authors.forename: A N
authors.initials: AN
authors.lastname: Waddell
authors.forename: W S
authors.initials: WS
authors.lastname: Crysdale
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005931:Glottis / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D006801:Humans; D015552:Injections, Intralesional; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D053685:Laser Therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D010212:Papilloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir