Studies on the constituents of Leonurus sibiricus L.
Two new furanoditerpene-lactones, LS-1 (1) and LS-2 (2), were isolated along with four known furanoditerpene-lactones 3, 4, 5 and 6 from the aerial part of Leonurus sibiricus L. The structures of the new compounds were determined by spectroscopic means. Compounds 1-6 isolated here exhibited moderate cytotoxic activity (IC(50)=50-60 microg/ml) against leukemia cells (L 1210) in tissue culture.
Satoh
Mitsuru
M
Showa College of Pharmaceutical Sciences, Tokyo, Japan. ms@ac.shyaku.ac.jp
Satoh
Yoshio
Y
Isobe
Kimiaki
K
Fujimoto
Yasuo
Y
D031332:Leonurus; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010936:Plant Extracts