[Serum antiretinal antibodies titres in patients with endogenous posterior uveitis in 12 months follow-up period].
OBJECTIVE
To evaluate changes of serum antiretinal antibodies titres (ARA) in patients with idiopathic posterior uveitis in 12 months follow-up period.


METHODS
50 patients (29 women and 21 men) in age 15-70 yrs with endogenous posterior uveitis were examined. In all cases serum ARA titres were determined by indirect immunofluorescence test on normal monkey retina as a substrate and FITC-labelled anti-human IgA, IgG, IgM serum (Euroimmun-Niemcy). ARA were scored in active stage of the disease and 1, 3, 6, 12 months after the immunosuppressive therapy was started.


RESULTS
Before treatment in active stage of the disease, the ARA were present in serum of 40 patients (80%). The range of serum ARA titres was 1:10 to 1:320. In 10 patients (20%) the serum ARA levels were not detectable. In the last control the ARA were detected in sera of 20% of patients in titres 1:10 to 1:40.


CONCLUSIONS
1. The presence of ARA in serum of 80% patients with active endogenous posterior uveitis indicates their involvement in the etiopathogenesis of this disease. 2. The assessment of serum ARA in patients with idiopathic posterior can act as an indicator of immunosuppressive therapy efficacy. 3. Serum ARA analysis is not a specific diagnostic test for endogenous posterior uveitis because ARA can be present in serum of patients with other ocular disorders.
Kubicka-Trzaska
Agnieszka
A
Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D015866:Uveitis, Posterior / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007166:Immunosuppressive Agents