title: Nonhuman primate model for Listeria monocytogenes-induced stillbirths.
abstract: Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytogenes infection as the cause of pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated from maternal feces, indicating that L. monocytogenes had survived and had probably colonized the gastrointestinal tract. Antibodies and antigen-specific lymphocyte proliferation against Listeria increased in animals that had stillbirths.
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, Georgia 30602, USA. masmith@uga.edu
authors.forename: Mary Alice
authors.initials: MA
authors.lastname: Smith
authors.forename: Kazue
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brackett
authors.forename: Harold M
authors.initials: HM
authors.lastname: McClure
authors.forename: Richard B
authors.initials: RB
authors.lastname: Raybourne
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Williams
authors.forename: Uma S
authors.initials: US
authors.lastname: Babu
authors.forename: Glenn O
authors.initials: GO
authors.lastname: Ware
authors.forename: J Roger
authors.initials: JR
authors.lastname: Broderson
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D004195:Disease Models, Animal; D016521:Electrophoresis, Gel, Pulsed-Field; D005243:Feces / Q000382:microbiology; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D008089:Listeria monocytogenes / Q000302:isolation & purification; D008088:Listeriosis / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D011247:Pregnancy
chemical_list: D000907:Antibodies, Bacterial