title: Vitamins A and E in serum in relation to weight and lung function in patients with advanced pulmonary disease.
abstract: The objective of the study was to examine whether serum concentrations of retinol (vitamin A) and alpha-, beta-, and gamma-tocopherols (vitamin E) are affected by underweight and weight gain. The analysis was carried out in underweight (n = 42, of whom 24 had chronic obstructive pulmonary disease) and normal-weight (n = 29, of whom 16 had chronic obstructive pulmonary disease) candidates for lung transplantation before and after dietary intervention for weight gain. In all the patients, serum concentrations of retinol at baseline and changes in retinol were positively associated with body mass index (unstandardized regression coefficient, b = 0.03; p = 0.05) and an increase in weight (b = 0.09, p = 0.02) after dietary intervention, respectively. At baseline, serum retinol concentrations were positively correlated with forced vital capacity (b = 0.24, p < 0.05) and forced expiratory volume in one second (b = 0.17, p < 0.05). In patients with chronic obstructive pulmonary disease (COPD), tocopherols were higher in the underweight patients than in the normal-weight ones, while it was an opposite tendency in patients with other lung diseases. Only in patients with lung diseases other than COPD was there found a positive association between tocopherols and lung gas diffusion. In patients with other diagnoses compared with patients with COPD, a positive change in serum tocopherol status after weight gain was suggested.
authors.affiliation: Department of Respiratory Medicine, Medical Department, Rikshospitalet, Oslo, Norway. liv.forli@rikshospitalet.no
authors.forename: Liv
authors.initials: L
authors.lastname: Førli
authors.forename: Jan I
authors.initials: JI
authors.lastname: Pedersen
authors.forename: Oystein
authors.initials: O
authors.lastname: Bjørtuft
authors.forename: Rune
authors.initials: R
authors.lastname: Blomhoff
authors.forename: Johan
authors.initials: J
authors.lastname: Kofstad
authors.forename: Jacob
authors.initials: J
authors.lastname: Boe
mesh_terms: D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology* / Q000628:therapy; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D018529:Nutritional Support; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D012129:Respiratory Function Tests; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D015430:Weight Gain; D024502:alpha-Tocopherol / Q000097:blood; D024503:beta-Tocopherol / Q000097:blood; D024504:gamma-Tocopherol / Q000097:blood
chemical_list: D014801:Vitamin A; D014810:Vitamin E; D024504:gamma-Tocopherol; D024503:beta-Tocopherol; D024502:alpha-Tocopherol