STAT1-dependent innate immunity to a Norwalk-like virus.
Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.
Karst
Stephanie M
SM
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wobus
Christiane E
CE
Lay
Margarita
M
Davidson
John
J
Virgin
Herbert W
HW
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001921:Brain / Q000821:virology; D017250:Caliciviridae Infections / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D016654:Genes, RAG-1; D016679:Genome, Viral; D018398:Homeodomain Proteins / Q000502:physiology; D007113:Immunity, Innate; D016867:Immunocompromised Host; D007422:Intestines / Q000821:virology; D008099:Liver / Q000821:virology; D008565:Membrane Proteins; D051379:Mice; D009154:Mutation; D029322:Norovirus / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification* / Q000472:pathogenicity; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000502:physiology; D050794:STAT1 Transcription Factor; D013154:Spleen / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014774:Virulence; D000096743:Interferon gamma Receptor
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D008565:Membrane Proteins; D012367:RNA, Viral; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D050794:STAT1 Transcription Factor; D015534:Trans-Activators; D000096743:Interferon gamma Receptor; C499308:Rag2 protein, mouse; C494080:Stat1 protein, mouse; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein