High-dose verapamil + trandolapril-induced thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) is a syndrome characterized by microangiopathic haemolytic anaemia, thrombocytopenia, and several variable signs of organ damage due to the platelet thrombi in the microcirculation. This article reports a case with TMA which developed after ingestion of a high-dose combination of verapamil and trandolapril. To the authors' knowledge, no prior cases of TMA induced by trandolapril (an angiotensin-converting enzyme inhibitor) and verapamil (a calcium channel blocker) have been reported in the literature.
Gokel
Yuksel
Y
Department of Emergency Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. ygokel@mail.cu.edu.tr
Paydas
Saime
S
Acikalin
Ayca
A
Bozkurt
Abdi
A
D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D001772:Blood Cell Count; D062787:Drug Overdose; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008833:Microcirculation / Q000187:drug effects; D013921:Thrombocytopenia / Q000139:chemically induced*; D013997:Time Factors; D014700:Verapamil / Q000009:adverse effects*
D006454:Hemoglobins; D007211:Indoles; C052035:trandolapril; D014700:Verapamil