[Effect of mexidol on the homeostasis and lipid peroxidation in paracetamol poisoning].
It is established that mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) influences the state of homeostasis in guinea pigs intoxicated with paracetamol. Paracetamol administered in toxic doses disturbs the functions of liver and kidneys, violates the lipid, carbohydrate, and mineral metabolism, activates the lipid peroxidation (LPO) process, and decreases the level of antioxidant protection. Treatment of the test animals with mexidol (25 mg/kg) decreases the cytolysis of hepatocytes, the development of cholestasis, the degree of hepatocellular insufficiency, the growth of endogenous intoxication, the drop of calcium content, the growth of iron content in the blood serum, and the content of final LPO products. The mexidol treatment activated the enzymatic chain of the antioxidant system.
Katikova
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Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D006168:Guinea Pigs; D006706:Homeostasis / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D011041:Poisoning / Q000378:metabolism
D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate; D000082:Acetaminophen