title: Paroxysmal cold hemoglobinuria and cardiopulmonary bypass.
abstract: Paroxysmal cold hemoglobinuria, a cold-reactive autoimmune disease associated with the Donath-Landsteiner antibody, has not been described in patients undergoing cardiac surgery. We report a case of mitral valve replacement in a woman with a positive Donath-Landsteiner antibody and a history of recurrent hemolysis and hemoglobinuria secondary to cold exposure. Successful perioperative management is described, as is a discussion of paroxysmal cold hemoglobinuria.
authors.affiliation: Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Kypson
authors.forename: John J
authors.initials: JJ
authors.lastname: Warner
authors.forename: Marilyn J
authors.initials: MJ
authors.lastname: Telen
authors.forename: Carmelo A
authors.initials: CA
authors.lastname: Milano
mesh_terms: D002315:Cardiopulmonary Bypass; D015897:Comorbidity; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D019918:Heart Valve Prosthesis Implantation; D006457:Hemoglobinuria, Paroxysmal / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000453:epidemiology* / Q000601:surgery*