[Humoral immune response to the retinal S-antigen in premature infants and its role in the development and course of retinopathy of prematurity].
The humoral immune response to the retinal S-antigen was studied in premature babies with active and cicatricle stages of retinopathy of the premature (RP) and in the controls (102 serum test). The presence of antibodies to the S-antigen of classes IgG and IgM was established by the enzyme multiplied analysis and by an authors' developed test-system. A definite specific humoral response to the S-antigen correlated with the nature of the course and prognosis of the disease was found in 71% of cases. The first peak of IgM-antibodies was found in babies of the risk-group (preretinopathy), it correlated with a poor prognosis (progression of RP). The second peak was highly pronounced in babies with the terminal cicatricle stages of RP. The wave-like dynamics of IgG-antibodies suggests that specific circulating immune complexes shape up. The role of immune responses, induced by the retinal S-antigen, in the RP pathogenesis is discussed.
Katargina
L A
LA
Slepova
O S
OS
Skripets
P P
PP
Dement'eva
G M
GM
Chernonog
I N
IN
Kalamkarov
G R
GR
D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D019393:Arrestin / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000209:etiology / Q000276:immunology*; D012307:Risk Factors
D000936:Antigen-Antibody Complex; D019393:Arrestin; D007074:Immunoglobulin G; D007075:Immunoglobulin M