Six new constituents from an Ascomycete, Chaetomium quadrangulatum, found in a screening study focused on monoamine oxidase inhibitory activity.
A screening study focusing on monoamine oxidase inhibitory activity on the EtOAc extract of an Ascomycete Chaetomium quadrangulatum, which previously gave five unique chromones possessing this activity (chaetoquadrins A-E (1-5)), this time afforded six new constituents termed chaetoquadrins F-K (6-11) in addition to 1-5. The structures of 6-11 have been deduced on the basis of spectral and chemical data, and 7 and 8 have shown appreciable monoamine oxidase inhibitory activity.
Fujimoto
Haruhiro
H
Graduate School of Pharmaceutical Sciences, Chiba University, Japan. fujimoto@p.chiga-u.ac.jp
Nozawa
Masato
M
Okuyama
Emi
E
Ishibashi
Masami
M
D002597:Chaetomium / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors