Developmental aspects of language processing: fMRI of verbal fluency in children and adults.
We examined developmental differences, in location and extent of fMRI language activation maps, between adults and children while performing a semantic fluency task. We studied 29 adults and 16 children with echo planar imaging BOLD fMRI at 1.5 T using covert semantic verbal fluency (generation of words to categories compared to rest) using a block design. Post task testing was administered to assess performance. Individual data were analyzed with an a priori region of interest approach from t maps (t = 4) and asymmetry indices (AI). Group studies were analyzed using SPM 99 (Wellcome, UK; fixed effect, corrected P < 0.0001). We found no significant differences in location or laterality of activation between adults and children for a semantic verbal fluency task. Adults activated more pixels than children in left inferior frontal gyrus and left middle frontal gyrus, but AIs were the similar across ages (r(2) < 0.09). Extent or laterality of activation was not affected by performance (r(2) < 0.15). The brain areas that process semantic verbal fluency are similar in children and adults. The laterality of activation does not change appreciably with age and appears to be strongly lateralized by age 7 years.
Gaillard
William D
WD
Department of Neurology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA. gaillardw@ninds.nih.gov
Sachs
Bonnie C
BC
Whitnah
Joseph R
JR
Ahmad
Zaaira
Z
Balsamo
Lyn M
LM
Petrella
Jeffrey R
JR
Braniecki
Suzanne H
SH
McKinney
Christopher M
CM
Hunter
Kevin
K
Xu
Ben
B
Grandin
Cecile B
CB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D014796:Visual Perception / Q000502:physiology*