title: Altered chemokine receptor sensitivity in FVBN202 rat neu transgenic mice.
abstract: We report here that breast cancer cells from spontaneous tumors that arise in rat neu transgenic mice produce several chemokines capable of acting upon cells of the immune system. Moreover, mice bearing these spontaneous tumors possess splenic T cells as well as CD11c+, CD11b+ and CD19+ cells with an altered sensitivity to recombinant chemokines compared to naïve mice. A comparison between T-cell migration and the level of chemokines produced by the tumor cells revealed that the altered chemotactic activity was not a direct consequence of tumor-derived chemokines. These data suggest that a growing tumor may indirectly alter leukocyte chemotactic activity.
authors.affiliation: Department of Biology, Lafayette College, Easton, PA, USA. kurtr@lafayette.edu
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kurt
authors.forename: Marissa
authors.initials: M
authors.lastname: Bauck
authors.forename: Sarah
authors.initials: S
authors.lastname: Harma
authors.forename: Evan
authors.initials: E
authors.lastname: Adler
authors.forename: Peter
authors.initials: P
authors.lastname: Vitiello
authors.forename: Ketura Preya
authors.initials: KP
authors.lastname: Wisner
authors.forename: Shane
authors.initials: S
authors.lastname: Tackitt
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Urba
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000276:immunology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008213:Lymphocyte Activation; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D019707:Receptors, Chemokine / Q000276:immunology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D017252:CD3 Complex; D018925:Chemokines; D012333:RNA, Messenger; D019707:Receptors, Chemokine