title: Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative combined with a bovine-derived xenograft.
abstract: The purpose of the present case report study was to clinically and histologically evaluate the healing of deep intrabony defects following treatment with either a combination of an enamel matrix protein derivative (EMD) and a bovine-derived xenograft (BDX) or with BDX alone. Three female patients with generalized marginal periodontitis and presenting one advanced intrabony defect each were treated with either a combination of EMD + BDX (two defects) or with BDX alone (one defect). The postoperative healing was uneventful in all three cases. Six months after surgery, a gain of clinical attachment was measured at all treated sites. The histologic examination revealed that all three defects healed with a new connective tissue attachment (ie, new cellular cementum with inserting collagen fibers) and new bone. Most of the BDX particles were surrounded by a bone-like tissue. No direct contact between BDX particles and the root surface (cementum or dentin) was observed. Within their limits, the present data indicate that treatment with either EMD + BDX or with BDX alone may enhance the formation of new connective tissue attachment and new bone in human intrabony defects.
authors.affiliation: Department of Conservative Dentistry, Johannes Gutenberg University, Mainz, Germany. anton.sculean@gmx.de
authors.forename: Anton
authors.initials: A
authors.lastname: Sculean
authors.forename: Peter
authors.initials: P
authors.lastname: Windisch
authors.forename: Tibor
authors.initials: T
authors.lastname: Keglevich
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Chiantella
authors.forename: István
authors.initials: I
authors.lastname: Gera
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Donos
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010518:Periodontitis / Q000473:pathology / Q000601:surgery; D014183:Transplantation, Heterologous; D014945:Wound Healing
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D003094:Collagen