title: [A retrospective study of clinical manifestation and human papilloma virus detection of oral condyloma acuminate in children].
abstract: OBJECTIVE
  The aim of this study is to study genotype, transmission, clinical and pathological characteristics, and prognosis of oral condyloma acuminate (CA) in children.
  
  
  METHODS
  The authors retrospected the clinical characteristics and slices of HE staining of six cases which have been diagnosed as oral CA and, performed inmunohistochemistry (IHC) and in situ hybridization (ISH) analysis to detect the DNA of human papilloma virus in 5 cases.
  
  
  RESULTS
  Oral CA often happened in the hard or soft plates of children of two-year-old. Most of them came from the families had been infected by human papilloma virus (HPV). Histological examination demonstrated that koilocytes were common in the upper spinous and corneal layers. HPV was detected in all cases. HPV16/18-E6 antigen was positive in 4 of 5 cases examined. The result of ISH only show one case was HPV6- and HPV11-positive, and the other case was HPV-positive, but HPV could not be detected when recurring.
  
  
  CONCLUSIONS
  The pathogen leading to oral condyloma acuminate (CA) and the transmission way of children may be different from that of adults.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: Zhixiu
authors.initials: Z
authors.lastname: He
authors.forename: Laikui
authors.initials: L
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D008297:Male; D009856:Oncogene Proteins, Viral / Q000032:analysis; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000821:virology*; D012008:Recurrence; D012097:Repressor Proteins; D012189:Retrospective Studies; D013280:Stomatitis / Q000175:diagnosis / Q000821:virology*
chemical_list: D004279:DNA, Viral; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins