Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major.
Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.
Zaph
Colby
C
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Scott
Phillip
P
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D054357:Chemokine CXCL10; D018925:Chemokines / Q000235:genetics*; D019743:Chemokines, CXC / Q000235:genetics; D005786:Gene Expression Regulation; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000502:physiology*; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H
D001426:Bacterial Proteins; D054357:Chemokine CXCL10; D018925:Chemokines; D019743:Chemokines, CXC; D008565:Membrane Proteins; D018664:Interleukin-12; D007371:Interferon-gamma