Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis.
OBJECTIVE
To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA).


METHODS
Genotyping for these IL-2 variants was performed by a polymerase chain reaction restriction fragment length polymorphism method in 174 RA patients and 153 control individuals.


RESULTS
No statistically significant differences were observed when the -384 and 114 IL-2 genotype distributions between RA patients and healthy controls were compared. In addition, no association was found between the IL-2 genotypes with any demographic and clinical variables tested.


CONCLUSIONS
Our results provide no evidence for genetic association conferred by the -384 and 114 IL-2 SNP with respect to susceptibility and severity of RA.
Fedetz
Maria
M
Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain.
Matesanz
Fuencisla
F
Cáliz
Rafael
R
Ferrer
Miguel Angel
MA
Collado
Maria Dolores
MD
Alcina
Antonio
A
Martín
Javier
J
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012720:Severity of Illness Index
D007376:Interleukin-2