Reproductive semi-cloning respecting biparental origin. A biologically unsound principle.
The original debate article proposed the use of "semi-cloning" as a viable method for assisted reproduction. This debate counters the proposal as being biologically unsound. Given the fundamental limitations of chromosomal segregation and genomic imprinting, the notion of using the MII oocyte to drive haploidization of a somatic cell genome and thereby obtain a substitute for authentic gametes is ill-conceived and untenable.
Tateno
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Department of Biological Sciences, Asahikawa Medical College, Asahikawa, Japan.
Latham
K E
KE
Yanagimachi
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R
D020090:Chromosome Segregation; D019976:Cloning, Organism / Q000379:methods*; D005260:Female; D018392:Genomic Imprinting; D006238:Haploidy; D006801:Humans; D008297:Male; D010290:Parents; D027724:Reproductive Techniques, Assisted