A novel constituent from Rollinia mucosa, rollicosin, and a new approach to develop annonaceous acetogenins as potential antitumor agents.
Rollicosin (1), a new Annonaceous acetogenin, was isolated from the unripe fruits of Rollinia mucosa. Rollicosin (1) is the first compound of this type to contain lactone moieties on both sides of the aliphatic chain and to lack either tetrahydrofuran or tetrahydropyran rings. Its structure was determined on the basis of spectroscopic analyses. This compound may serve as a new prototype molecule to develop Annonaceous acetogenins as potential antitumor agents.
Liaw
Chih-Chuang
CC
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Chang
Fang-Rong
FR
Wu
Ming-Jung
MJ
Wu
Yang-Chang
YC
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D031045:Rollinia / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C475244:rollicosin; C082488:muricatacin