title: Docetaxel, cisplatin, 5-fluorouracil (TPF)-based induction chemotherapy for head and neck cancer and the case for sequential, combined-modality treatment.
abstract: Since the publication of the Veterans Affairs study in the early 1990s, much has been learned regarding the role of chemotherapy, radiation therapy, and more importantly, the role of combined-modality treatment with chemoradiation in the therapy of locally advanced head and neck cancer. There continues to be widespread variation and controversy in the timing, schedule, and intensity of chemotherapy and chemoradiation. Herein, we present the various approaches currently used in the year 2003 with a specific emphasis on the role of sequential combined-modality therapy combining chemotherapy, chemoradiotherapy, and surgery in the treatment of these malignancies.
authors.affiliation: Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Haddad
authors.forename: Roy B
authors.initials: RB
authors.lastname: Tishler
authors.forename: Charles M
authors.initials: CM
authors.lastname: Norris
authors.forename: Anand
authors.initials: A
authors.lastname: Mahadevan
authors.forename: Paul
authors.initials: P
authors.lastname: Busse
authors.forename: Lori
authors.initials: L
authors.lastname: Wirth
authors.forename: Laura A
authors.initials: LA
authors.lastname: Goguen
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Sullivan
authors.forename: Rosemary
authors.initials: R
authors.lastname: Costello
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Case
authors.forename: Marshall R
authors.initials: MR
authors.lastname: Posner
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D043823:Taxoids
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil