Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells.
Several quinolines were synthesized and evaluated against HTLV-1 infected cells. Some of them were able to inhibit HTLV-1 cell-growth at 10 microM. Some structure-activity relationships were observed.
Fournet
Alain
A
Laboratoire de Pharmacognosie (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J. B. Clément, 92296 Châtenay-Malabry, France.
Mahieux
Renaud
R
Fakhfakh
Mohammed A
MA
Franck
Xavier
X
Hocquemiller
Reynald
R
Figadère
Bruno
B
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002472:Cell Transformation, Viral; D015490:HTLV-I Infections / Q000188:drug therapy*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000166:cytology / Q000382:microbiology
D011804:Quinolines