[The influence of peritoneal dialysis on the pulmonary function of patients with end-stage renal disease].
OBJECTIVE
To demonstrate the change of pulmonary function in patients with end-stage renal disease(ESRD) before and after peritoneal dialysis (PD).


METHODS
In this study were measured the forced vital capacity (FVC), maximum breathing capacity (MBC), the forced expiratory volume of the first second (FEV1), maximal expiratory flow (MEF), maximal mid-expiratory flow rate (MMEF), 25% of maximal expiratory flow (V25), and the diffusion of co in lung (DLco) for 50 patients with end-stage renal disease and 20 normal subjects. All the indexes were determined again in 30 ESRD patients two months after peritoneal dialysis.


RESULTS
The indexes of pulmonary ventilation (FVC, MBC, FEV1, PEF, MMEF, V25) and the pulmonary diffusion DLco were lower in the ESRD patients than in the controls. FEV1, PEF, MMEF and V25 were improved markedly after peritoneal dialysis in ESRD patients (P < 0.05); FVC, MBC, and DLco were of no change (P > 0.05).


CONCLUSIONS
The function of pulmonary ventilation and diffusion are decreased in patients with ESRD accompanied with airways obstruction. Peritoneal dialysis can improve airways obstruction remarkably, but it has no effect on the function of pulmonary ventilation and diffusion.
Tang
Xiaohong
X
Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Youjuan
Y
Yang
Lichuan
L
Yuan
Yuru
Y
D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008451:Maximal Voluntary Ventilation; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects; D011653:Pulmonary Diffusing Capacity; D014511:Uremia / Q000503:physiopathology / Q000628:therapy