Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders.
This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide.
Durand
Grégory
G
Laboratoire de Chimie BioOrganique et des Systèmes Moléculaire Vectoriels, Faculté des Sciences, 33 rue Louis Pasteur, 84000 Avignon, France.
Polidori
Ange
A
Salles
Jean-Pierre
JP
Pucci
Bernard
B
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D061945:Caspase Inhibitors; D020169:Caspases / Q000145:classification; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006031:Glycosylation; D006861:Hydrogen Peroxide / Q000737:chemistry; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009474:Neurons / Q000166:cytology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D019097:Spin Trapping
D000975:Antioxidants; D061945:Caspase Inhibitors; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; C015388:nitrones; D006861:Hydrogen Peroxide; D020169:Caspases