The ldb1 mutant of Saccharomyces cerevisiae is defective in Pmr1p, the yeast secretory pathway/Golgi Ca(2+)/Mn(2+)-ATPase.
The LDB1 gene of Saccharomyces cerevisiae was identified by complementation of the ldb1 mutant phenotype with a genomic library. We found that the ldb1 defect is complemented by PMR1 which codes for the yeast secretory pathway/Golgi Ca(2+)/Mn(2+)-ATPase. Besides that, the analysis of a null mutation of the PMR1 gene revealed a phenotype identical to that of ldb1 mutant. Thus, LDB1 must be considered a synonym of PMR1.
Olivero
Isabel
I
Department of Microbiology. University of Extremadura, 06071, Badajoz, Spain.
Corbacho
Isaac
I
Hernández
Luis M
LM
D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D015966:Gene Expression Regulation, Fungal; D005816:Genetic Complementation Test; D006056:Golgi Apparatus / Q000201:enzymology*; D008345:Manganese / Q000378:metabolism; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014170:Transformation, Genetic
D029701:Saccharomyces cerevisiae Proteins; D008345:Manganese; D000252:Calcium-Transporting ATPases; D002118:Calcium