[Integrated project for the translational research on pancreatic ductal carcinoma].
The narrow chances of therapy and the poor prognosis of pancreatic cancer make basic research a crucial way for both a better knowledge and a possible improvement in the treatment of this disease. The very limited availability of pancreatic specimen for genetic and biological studies forced the researchers to plan "in vitro" and "in vivo" models in order to overcome this handicap. Among the animal models, the one according to Fu et al. seemed to be the most helpful and effective approach. Nevertheless, being this model complex and failing in main perspective applications, an enlarged project perpetuating B-lymphocytes of the patients, successfully xenografting from vitally criopreserved specimen and developing cell lines from xenografts was planned. According to the aim of our project, a really perpetual and renewable bank of tumoral and normal tissue from patients suffering from pancreatic carcinoma was obtained. This model is also expected to be an effective approach for the evaluation of experimental chemotherapeutic schedules and new gene therapy assessment.
Marcucci
Stefano
S
UO di Endocrinochirurgia, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Università degli Studi di Verona.
Bonora
Antonio
A
Falconi
Massimo
M
Sorio
Claudio
C
Orlandini
Simonetta
S
Beghelli
Stefania
S
Cristofori
Patrizia
P
Dal Negro
Gianni
G
Marchiori
Pier Nicola
PN
Bassi
Claudio
C
Scarpa
Aldo
A
Pederzoli
Paolo
P
D000818:Animals; D035843:Biomedical Research; D021441:Carcinoma, Pancreatic Ductal; D006801:Humans; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms; D014015:Tissue Banks