Leptin resistance - or why leptin fails to work in obesity.
In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.
El-Haschimi
K
K
Department of Endocrinology and Metabolism, Otto-Von-Guericke University, Magdeburg, Germany.
Lehnert
H
H
D000818:Animals; D004351:Drug Resistance; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D020738:Leptin / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy*
D020738:Leptin