title: Maternal and fetal outcomes in pregnancy complicated with acute leukemia: a single institutional experience with 10 pregnancies at 16 years.
abstract: The incidence of acute leukemia in pregnancy is low and the management of acute leukemia during pregnancy is difficult. We have observed a total of 10 pregnancies in 8 patients. Six of the patients had acute myeloblastic leukemia (AML) and two of them had acute lymphoblastic leukemia (ALL). Three of the pregnancies were diagnosed when the leukemia was in remission, six at the time of leukemia diagnosis and one at the time of leukemic relapse. Six of the pregnancies were found in first trimester, three in the second and one early in the third. Three pregnancies ended with spontaneous abortion, three with intrauterine death and three with medical termination. One of spontaneous abortions and one intrauterine death developed during combination chemotherapy (daunorubicin, cytarabine). Only 1 healthy baby survived from the 10 pregnancies and this child was the not exposed to chemotherapeutic agents. None of the cases had gynecologic and obstetric complications. Five of eight pregnant women with leukemia died because of the primary disease.
authors.affiliation: Division of Haematology, Department of Internal Medicine, Uludag University School of Medicine, Uludag University Hospital, Bursa, Turkey. ridvanali@uludag.edu.tr
authors.forename: Ridvan
authors.initials: R
authors.lastname: Ali
authors.forename: Fahir
authors.initials: F
authors.lastname: Ozkalemkaş
authors.forename: Tülay
authors.initials: T
authors.lastname: Ozçelik
authors.forename: Vildan
authors.initials: V
authors.lastname: Ozkocaman
authors.forename: Ulkü
authors.initials: U
authors.lastname: Ozan
authors.forename: Yalçin
authors.initials: Y
authors.lastname: Kimya
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tunali
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000032:Abortion, Therapeutic; D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000453:epidemiology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000453:epidemiology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: D003561:Cytarabine; D003630:Daunorubicin