title: Ischemic "memory image" in acute myocardial infarction of 123I-BMIPP after reperfusion therapy: a comparison with 99mTc-pyrophosphate and 201Tl dual-isotope SPECT.
abstract: Ischemic "memory image" is a phenomenon of 123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) in which an area at risk of acute myocardial infarction (AMI), could be detected as a defect in a couple of weeks even after successful reperfusion therapy. The purpose of this study was to clarify the incidence of the ischemic "memory image" of 123I-BMIPP in patients with AMI by comparing 99mTc-PYP and 201Tl dual-isotope SPECT. Materials consisted of 14 patients with successfully reperfused AMI and 20 patients with old myocardial infarction (OMI). All AMI patients underwent PYP/Tl dual-isotope SPECT within 1 week after the onset of AMI, and BMIPP SPECT was performed within 1 week after the PYP/Tl dual-isotope SPECT. The extent and severity of the defect of BMIPP and Tl were visually scored into four grades: 0 = no defect to 3 = large or severe defect. These scores were compared. PYP positive AMI lesions were concordant with BMIPP defects (13/14). In AMI, both the extent and severity scores of BMIPP were higher than 201Tl (p < 0.001). Differences (BMIPP - Tl) of extent and severity scores were greater in AMI than in OMI (p < 0.001). In conclusion, the ischemic "memory image" obtained by means of the BMIPP is a common phenomenon (13/14) in AMI, and helpful in evaluating the area at risk.
authors.affiliation: Department of Radiology, Ehime University School of Medicine, Shitsukawa, Japan. tmochi@m.ehime-u.ac.jp
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higashino
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Takanori
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Junpei
authors.initials: J
authors.lastname: Ikezoe
mesh_terms: D000368:Aged; D005188:False Negative Reactions; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D015425:Myocardial Reperfusion / Q000009:adverse effects; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging* / Q000209:etiology; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016698:Technetium Tc 99m Pyrophosphate; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D005227:Fatty Acids; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; C027549:thallium chloride; D016698:Technetium Tc 99m Pyrophosphate; D013793:Thallium