Remarkable 1,6-acyclic diastereoselection in the coupling of a novel butadienyl di-indium compound with aldehydes.
The reaction between a novel butadienyl di-indium reagent and aldehydes showed remarkable 1,6-diastereoselectivity to give acetylenic diol products as a single diastereomer. A bicyclic transition state formed through intramolecular chelation control was proposed that might account for the high 1,6-diastereoselection result.
Miao
Weishi
W
Department of Chemistry, McGill University, Montreal, Quebec, Canada, H3A 2K6.
Lu
Wenshuo
W
Chan
Tak Hang
TH