MUC-1 mucin protein expression in B-cell lymphomas.
We have recently shown that MUC1, mapped to the chromosomal band 1q21, is rearranged or amplified in 15% of B-cell lymphomas and that rearrangement led to over-expression of MUC-1 mucin in a case of diffuse large B-cell lymphoma (DLBCL). To determine the incidence of MUC-1 mucin expression and its clinical significance in B-cell lymphomas, we investigated a panel of 113 cases by immunohistochemistry (IHC). MUC-1 mucin expression was detected in the majority of cases (92.9%), with moderate to high levels noted in 50.4% of all histologic subsets comprising DLBCL (82 cases), follicular lymphoma (FL) (15 cases), FL with transformation to DLBCL (4 cases), and other B-cell lymphomas (12 cases). No statistically significant correlation was found between MUC-1 mucin expression and MUC1 genomic status (amplification/rearrangement) evaluated by Southern blot analysis, and 1q21 abnormality by karyotypic analysis. For all cases, MUC-1 mucin expression correlated with a previous history of lymphoma (p=0.003).
Teruya-Feldstein
Julie
J
Department of Pathology, Cell Biology and Immunology Programs, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. feldstej@mskcc.org
Donnelly
Gerard B
GB
Goy
Andre
A
Hegde
Abhijith
A
Nanjangud
Gouri
G
Qin
Jing
J
Thaler
Howard
H
Gilles
Frederic
F
Dyomin
Vadim G
VG
Lloyd
Kenneth O
KO
Zelenetz
Andrew D
AD
Houldsworth
Jane
J
Chaganti
R S K
RS
D015139:Blotting, Southern; D015331:Cohort Studies; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000378:metabolism*; D018396:Mucin-1 / Q000235:genetics / Q000378:metabolism*
D018396:Mucin-1