Human papillomavirus therapy for the prevention and treatment of cervical cancer.
Cervical carcinoma is associated with human papillomavirus infection. Proliferation of cancer cells depends on the continual expression of the E6 and E7 viral oncogenes. This article includes treatment strategies that can interfere with expression or function of the proteins and immunotherapeutic approaches that can eliminate cells that express E6 and E7 proteins.
Khleif
Samir N
SN
Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Building 8, Room 4137, Bethesda, MD 20892, USA. khleif@nih.gov
D002455:Cell Division; D005260:Female; D006801:Humans; D007167:Immunotherapy; D027383:Papillomaviridae / Q000235:genetics / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000517:prevention & control*; D014158:Transcription, Genetic; D014412:Tumor Virus Infections / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy*; D014759:Viral Envelope Proteins / Q000235:genetics
D014759:Viral Envelope Proteins