title: Ceramide analogues in apoptosis: a new strategy for anticancer drug development.
abstract: A survey on the role played by ceramide within the sphingolmyelin pathway is here reported, taking into account its importance as an intracellular effector molecule in apoptosis. Recently, several analogs of ceramide, able to pass the cell membrane and then to induce apoptosis, have been developed as a new potential approach in anticancer therapy.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy. mmacchia@farm.unipi.it
authors.forename: Marco
authors.initials: M
authors.lastname: Macchia
authors.forename: Simone
authors.initials: S
authors.lastname: Bertini
authors.forename: Stefano
authors.initials: S
authors.lastname: Fogli
authors.forename: Elisa
authors.initials: E
authors.lastname: Giovannetti
authors.forename: Filippo
authors.initials: F
authors.lastname: Minutolo
authors.forename: Simona
authors.initials: S
authors.lastname: Rapposelli
authors.forename: Romano
authors.initials: R
authors.lastname: Danesi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002518:Ceramides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000502:physiology; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D002518:Ceramides