[Etio-pathogenic hypothesis of attention deficit disorder in children].
The aetiological factors of "attention deficit hyperactivity disorder" (ADHD) are multiple, and have an importance that vary according to the individual. Nevertheless, the current state of knowledge suggests a significant biological component to the pathophysiology of this problem, and a genetic influence in particular. It thus seems that ADHD is essentially characterised by its dimension of impulsivity, linked to a defect of inhibitor control, specifically implying certain cerebral structures as well as a dysfunction of the catecholaminergic systems, and in particular, the dopaminergic system. Certainly, environmental factors influence the symptomotology and expression of the problem, but it is noted that ADHD itself influences these factors.
Reneric
Jean-Philippe
JP
Centre hospitalier Charles-Perrens Centre de consultations spécialisées 33076 Bordeaux. jean-philippe.reneric@labopsy.u-bordeaux2.fr
Bouvard
Manuel-P
MP
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000502:physiology; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D011954:Receptors, Dopamine / Q000502:physiology*
D011954:Receptors, Dopamine