title: Skin dose and dose-area product values in patients undergoing intracoronary brachytherapy.
abstract: Entrance skin doses, dose-area product (DAP) values, fluoroscopy times and digital cine acquisition data were measured for 86 patients undergoing intracoronary brachytherapy procedures with beta sources, to estimate risk of skin injuries. Interventions were carried out in three dedicated X-ray interventional cardiology rooms equipped with X-ray systems operating in pulsed modes, with high filtration and edge filter options. Skin dose distribution was analysed in detail in 56 patients using slow films and thermoluminescent dosimetry. Digital recording of Digital Imaging and Communications in Medicine cine images also allowed analysis of the technical parameters used throughout the procedures. A protocol for clinical follow-up of these patients at the cardiology service is also presented, which prescribes special attention when a threshold dose is reached. Median values for DAP, fluoroscopy time and number of frames were 81.2 Gy cm(2), 17.5 min and 1569 frames, respectively, and maximum values were 323.3 Gy cm(2), 46.2 min and 3213 frames, respectively. In two cases, maximum skin doses in a procedure reached 3.5 Gy and 4.6 Gy. Comparing median values in this study, intracoronary brachytherapy involved approximately two-fold the DAP used in percutaneous transluminal coronary angioplasty procedures performed during the same period in the same catheterization laboratories, as a consequence of the need to monitor the radioactive source location used for the treatment of stenoses and the intravascular ultrasound. Special care must be paid in those cases of high dose in relation to potential patient skin injuries and late effects.
authors.affiliation: Interventional Cardiology Service, San Carlos University Hospital, 28040 Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vano
authors.forename: C
authors.initials: C
authors.lastname: Prieto
authors.forename: J M
authors.initials: JM
authors.lastname: Fernandez
authors.forename: L
authors.initials: L
authors.lastname: Gonzalez
authors.forename: M
authors.initials: M
authors.lastname: Sabate
authors.forename: C
authors.initials: C
authors.lastname: Galvan
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods; D006338:Heart Neoplasms / Q000532:radiotherapy; D006801:Humans; D011829:Radiation Dosage; D015641:Radiography, Interventional / Q000009:adverse effects* / Q000379:methods; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects*; D016896:Treatment Outcome