title: Diagnosis and management of hepatic copper accumulation in a Skye terrier.
abstract: A one-year-old, neutered female Skye terrier presented with anorexia, vomiting, seizures and ascites. Portal venography demonstrated the presence of multiple acquired portosystemic shunts. Hepatic biopsy confirmed the presence of copper accumulation and fibrosis. Treatment included ursodeoxycholic acid therapy, colchicine and oral zinc. To the authors' knowledge, this is the first case report detailing successful management of Skye terrier hepatopathy.
authors.affiliation: Department of Small Animal Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH.
authors.forename: Y L
authors.initials: YL
authors.lastname: McGrotty
authors.forename: I K
authors.initials: IK
authors.lastname: Ramsey
authors.forename: C M
authors.initials: CM
authors.lastname: Knottenbelt
mesh_terms: D000818:Animals; D001201:Ascites / Q000209:etiology / Q000662:veterinary; D003078:Colchicine / Q000008:administration & dosage; D003300:Copper / Q000378:metabolism*; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D011859:Radiography; D012640:Seizures / Q000209:etiology / Q000662:veterinary; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage; D014839:Vomiting / Q000209:etiology / Q000662:veterinary; D015032:Zinc / Q000008:administration & dosage
chemical_list: D014580:Ursodeoxycholic Acid; D003300:Copper; D015032:Zinc; D003078:Colchicine