Peripheral retinal nonperfusion associated with chronic myeloid leukemia.
OBJECTIVE
To report a case of peripheral retinal nonperfusion and chronic myeloid leukemia in a 23-year-old woman.


METHODS
Observational case report.


METHODS
A complete ophthalmic and systemic evaluation was performed.


RESULTS
Ophthalmic examination revealed peripheral retinal nonperfusion with retinal neovascularization in both eyes. Fluorescein angiography of both eyes showed a marked midperipheral and peripheral avascular retina temporally with arteriovenous anastomosis and seafan neovascularizations. Blood work showed no abnormalities, although marked leucocytosis (up to 750 x 10(9)/l) and thrombocytosis (646 x 10(9)/l) were present in 1998 when the patient was diagnosed with leukemia. Following treatment, the patient has been in remission.


CONCLUSIONS
Peripheral retinal nonperfusion with retinal neovascularization may occur as a complication of chronic myeloid leukemia. In contrast to other studies describing this association, our patient had a bilateral peripheral retinal nonperfusion with seafan neovascularizations without relapse of the myeloid leukemia and without any of the other retinal signs associated with chronic myeloid leukemia, such as tortuosity of veins, intraretinal or preretinal hemorrhages, and cotton-wool exudates.
Nobacht
Siamak
S
Department of Ophthalmology, University Medical Centre, Nijmegen, The Netherlands. s.nobacht@ohk.azn.nl
Vandoninck
Kathleen F K
KF
Deutman
August F
AF
Klevering
B Jeroen
BJ
D000328:Adult; D001164:Arteriovenous Fistula / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000503:physiopathology; D012039:Regional Blood Flow; D012164:Retinal Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D019572:Retinal Neoplasms / Q000150:complications* / Q000503:physiopathology; D015861:Retinal Neovascularization / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D012171:Retinal Vessels / Q000503:physiopathology*