title: Design and synthesis of potent N1-substituted indole melatonin receptor agonists.
abstract: The design and expeditious synthesis of two new indole analogs with up to 5-fold potency of that of melatonin is described.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis-Zografou, 157 71, Athens, Greece. tsotinis@pharm.uoa.gr
authors.forename: Andrew
authors.initials: A
authors.lastname: Tsotinis
authors.forename: Andreas
authors.initials: A
authors.lastname: Eleutheriades
authors.forename: Katherine
authors.initials: K
authors.lastname: Hough
authors.forename: David
authors.initials: D
authors.lastname: Sugden
mesh_terms: D000818:Animals; D015195:Drug Design; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008550:Melatonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011956:Receptors, Cell Surface / Q000819:agonists*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D044094:Receptors, Melatonin; D013329:Structure-Activity Relationship; D014982:Xenopus laevis / Q000378:metabolism
chemical_list: D007211:Indoles; D008024:Ligands; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D008550:Melatonin