Spermatogenic arrest in men with testicular hyperthermia.
Sperm is produced by a highly complex and poorly understood differentiation process known as spermatogenesis. Occupational exposure to high temperatures adversely affect testicular function, causing partial or complete spermatogenic arrest. Dyers, cooks, blast furnace workers, and men with varicocele are known to develop testicular hyperthermia, which leads to oligoasthenoteratozoospermia (OAT) and azoospermia. Semen analysis of 122 infertile men (and 25 fertile controls), following the WHO guidelines, 1999, showed azoospermia in 106 men and oligozoospermia in 16 men. Twenty azoospermic and fourteen oligozoospermic men had high testiculoepididymal temperatures, either due to occupational exposure to high temperature or varicocele. All the 14 oligozoospermic men showed a very high percentage of sperm with abnormal morphology, impaired motility and they were subclassified as OAT group. Observations made in this study reiterates that high intratesticular temperature causes partial or complete spermatogenic arrest and may lead to increased production of morphologically abnormal sperm with impaired motility. This inverse relationship of sperm function with elevated temperature has implications in clinical medicine both in understanding pathological states and for therapeutic measures.
Dada
Rima
R
Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Gupta
Narmada P
NP
Kucheria
Kiran
K
D000328:Adult; D005334:Fever / Q000097:blood / Q000209:etiology* / Q000235:genetics; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007248:Infertility, Male / Q000097:blood / Q000209:etiology* / Q000235:genetics; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D009845:Oligospermia / Q000097:blood / Q000209:etiology / Q000235:genetics; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology*; D013094:Spermatozoa / Q000002:abnormalities; D013737:Testis / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D014646:Varicocele / Q000097:blood / Q000150:complications / Q000235:genetics
D007986:Luteinizing Hormone