title: Nitroglycerin induces hyperalgesia in rats--a time-course study.
abstract: Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration. The effect of nitroglycerin on the nociceptive threshold was studied in rats by means of two experimental tests that explore different modalities of pain: the tail-flick test and the formalin test. Nitroglycerin induced a significant reduction in the latency of the tail flick 2 and 4 h after its administration. Similarly, formalin-induced pain-related behaviour increased significantly 2 and 4 h after nitroglycerin administration.
authors.affiliation: Laboratory of Pathophysiology of Integrative Autonomic Systems, University Centre for the Study of Adaptive Disorders and Headache (UCADH), IRCCS C. Mondino Institute of Neurology, Pavia, Italy. cristina.tassorelli@mondino.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Tassorelli
authors.forename: Rosaria
authors.initials: R
authors.lastname: Greco
authors.forename: Dechun
authors.initials: D
authors.lastname: Wang
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sandrini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005557:Formaldehyde; D006930:Hyperalgesia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D005557:Formaldehyde; D005996:Nitroglycerin