Pallidotomy in Parkinson's disease improves single-joint, repetitive, ballistic movements, but fails to modify multijoint, repetitive, gestural movements.
We studied 12 non-demented PD patients in on state before and 3 months after posteroventral pallidotomy (PVP), in order to evaluate the effects of surgery upon an unconstrained, multijoint skilled movement as well as a single joint, repetitive, ballistic movement. A Selspot II System was used for three-dimensional data acquisition, processing and reconstruction of limb trajectories. Specific wrist kinematic features of spatial accuracy (linearity and planarity), temporal attributes (acceleration and velocity), spatiotemporal relationships (velocity-curvature coupling), and joint kinematic variables (relationships between wrist and elbow velocities and relative arm angle amplitudes) for each cycle of movement were graphically and numerically analysed. QMC was applied to single joint, repetitive, ballistic movements. QMC significantly improved after PVP (P < 0.0006). However, wrist as well as joint kinematic variables of the gestural movements failed to change significantly after PVP. The lack of improvement of the kinematic abnormalities of the gestural movement in PD patients would indicate that they are unrelated to the basic motor deficit; most likely they are the result of a disruption of a complex of sensorimotor integration processes due to abnormal parieto-frontal basal ganglia interaction.
Merello
Marcelo
M
Neurology Department, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Balej
Jorge
J
Neurology Department, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Leiguarda
Ramon
R
Neurology Department, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
D020820:Dyskinesias / Q000503:physiopathology; D004550:Elbow / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005868:Gestures; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007596:Joints / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009068:Movement; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011597:Psychomotor Performance; D016896:Treatment Outcome; D014955:Wrist Joint / Q000503:physiopathology