A study on organic nitrates, Part VI. Synthesis and pharmacological activity of 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate.
Basing on the studies on the relationship between the structure and activity, we have synthesized a nitrate analogue of propranolol as potential donor of nitric oxide. The obtained 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate decreases blood pressure more than propranolol and slows the heart rate less than propranolol. It also affects peripheral vascular resistance less than propranolol.
Korzycka
Lucyna
L
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Owczarek
Jacek
J
Czarnecka
Elzbieta
E
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D009566:Nitrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits
C472831:1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate; D000959:Antihypertensive Agents; D009281:Naphthalenes; D009566:Nitrates; C421035:propyl nitrate; D011433:Propranolol