Extra-renal erythropoietin secretion after bilateral nephrectomy.
Serum concentrations of erythropoietin and soluble transferrin receptor were examined immediately after removal of the remaining kidney in a patient with a history of unilateral radical nephrectomy. Unexpectedly, the erythropoietin concentration increased from 18.2 U/L to 42.5 within 6 h after the operation. Soluble transferrin receptor (TfR) concentration rapidly decreased from 2,725 microgram/L to 1,548 during the 12-h postoperative period. Extra-renal erythropoietin secretion could increase to more than twice as much as the renal secretion of erythropoietin immediately after the loss of renal tissue, and the rise in erythropoietin could accelerate the recycling of TfR, thus causing a decrease in its serum concentration.
Nakanishi
Takeshi
T
Department of Kidney and Dialysis, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan. t-nkns@hyo-med.ac.jp
Horikawa
Seizaburo
S
Hiraoka
Keisuke
K
Izumi
Masaaki
M
Yoshimoto
Teturo
T
Shima
Hiroki
H
Takamitsu
Yoshihiro
Y
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D004921:Erythropoietin / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology* / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods; D011990:Receptors, Transferrin / Q000097:blood; D012083:Renin / Q000097:blood; D014882:Water-Electrolyte Balance / Q000502:physiology
D011990:Receptors, Transferrin; D004921:Erythropoietin; D012083:Renin