Role of tumor markers in the diagnosis of cystic and intraductal neoplasms.
Despite recent advances in imaging procedures, the correct diagnosis of cystic lesions of the pancreas is lacking in about one third of cases. Cyst fluid analysis can help in the differential diagnosis, particularly in patients with unilocular or paucilocular lesions, thus precluding unjustified resection in patients with benign cystic lesions of the pancreas. Although use of cystic fluid marker analysis is helpful in several situations, it is crucial to carefully evaluate the clinical context with appraisal of patient's demographics, clinical symptoms, and morphologic data. A multidisciplinary approach is advised and should improve the overall diagnostic performance and lead to better management strategies in patients presenting with such tumors of the pancreas.
Hammel
Pascal
P
Federation Médico-Chirurgicale d Hépato-Gastroentérologie Hôpital Beaujon (AP-HP), 92118 Clichy, France. pascal.hammel@bjn.ap-hop-paris.fr
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D018395:CA-19-9 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D020420:Cyst Fluid / Q000737:chemistry; D018282:Cystadenocarcinoma, Mucinous / Q000097:blood / Q000175:diagnosis; D018291:Cystadenoma, Mucinous / Q000097:blood / Q000175:diagnosis; D018293:Cystadenoma, Serous / Q000097:blood / Q000175:diagnosis; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D006801:Humans; D018396:Mucin-1 / Q000032:analysis; D010181:Pancreatic Cyst / Q000097:blood / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D018300:Papilloma, Intraductal / Q000097:blood / Q000175:diagnosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; C083825:CA-72-4 antigen; D002272:Carcinoembryonic Antigen; D018396:Mucin-1