[Current concepts on apoptotic signalling pathways: new targets for anticancer strategies].
Apoptosis is an essential physiological process that plays a critical role in development and cellular homeoastasis. This process is tightly regulated through multiple independent signalling pathways. Defects in apoptosis may contribute both to tumorigenesis and drug resistance. Understanding the molecular events that contribute to apoptosis enable a more rational approach to anticancer strategy development. These strategies will allow not only the development of new molecules targeting recently elucidated apoptotic signalling pathways, but also a better use of already kown drugs through new associations in so far as these target distinct signalling pathways.
Ségal-Bendirdjian
Evelyne
E
Inserm U496, Centre G. Hayem, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris. esegal@juputer.chu-stlouis.fr
Hillion
Josette
J
Belmokhtar
Chafké Ahmed
CA
D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D053477:Apoptotic Protease-Activating Factor 1; D020169:Caspases / Q000378:metabolism; D004789:Enzyme Activation; D008024:Ligands; D008562:Membrane Glycoproteins / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy; D011506:Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D053477:Apoptotic Protease-Activating Factor 1; D008024:Ligands; D008562:Membrane Glycoproteins; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha; D020169:Caspases