title: Measurement of functional residual capacity by nitrogen washout during partial ventilatory support.
abstract: OBJECTIVE
  Evaluation of an open circuit multiple breath nitrogen washout (MBNW) technique for measurement of functional residual capacity (FRC) during partial ventilatory support using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen.
  
  
  METHODS
  Measurements in a lung model with known reference volume simulating spontaneous breathing and duplicate measurements in patients breathing spontaneously with partial ventilatory support. SETTING. Experimental laboratory and intensive care units of a university hospital.
  
  
  METHODS
  Eighteen patients with acute respiratory failure.
  
  
  METHODS
  Change of FiO(2) from baseline to 1.0.
  
  
  RESULTS
  FRC was measured by MBNW during spontaneous breathing with continuous positive airway pressure, pressure support ventilation, proportional assist ventilation, automatic tube compensation, and airway pressure release ventilation. In the lung model, repeated measurements at three volumes were done with all partial ventilatory support modalities, and baseline FiO(2 )was varied with one mode and FRC. The mean of differences between MBNW (FRC(MBNW)) and reference was 28 ml (1.6%), and the 2.SD-interval was 84 ml (4.9%) for all modes. Measurements up to a baseline FiO(2) of 0.8 showed differences of 5 ml (-0.3%) and the 2.SD-interval of 38 ml (2.2%) between reference and FRC(MBNW). In 18 patients, 66 duplicate measurements revealed a mean difference of 30 ml (0.9%) with a coefficient of repeatability of 358 ml (13%) independent of ventilatory mode and chronological order.
  
  
  CONCLUSIONS
  This study suggests that, using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen, FRC can be determined with good repeatability in patients and good accuracy in a lung model during partial ventilatory support.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Spezielle Intensivmedizin, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. jzinserling@uni-bonn.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Zinserling
authors.forename: Hermann
authors.initials: H
authors.lastname: Wrigge
authors.forename: Dirk
authors.initials: D
authors.lastname: Varelmann
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hering
authors.forename: Christian
authors.initials: C
authors.lastname: Putensen
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care; D005652:Functional Residual Capacity; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism*; D011659:Pulmonary Gas Exchange; D015203:Reproducibility of Results; D012121:Respiration, Artificial / Q000295:instrumentation*; D012128:Respiratory Distress Syndrome / Q000628:therapy*
chemical_list: D009584:Nitrogen