Bullous pyoderma gangrenosum complicated by disseminated intravascular coagulation with subsequent myelodysplastic syndrome (chronic myelomonocytic leukemia).
A 33-year-old woman developed a bullous PG precursing a chronic myelomonocytic leukemia (CMML) complicated by life-threatening, disseminated, intravascular coagulation after administration of systemic corticosteroids in combination with immunosuppressant and antibiotic agents. Although the association between PG and leukemia, as well as the coincidence of disseminated intravascular coagulation (DIC) and leukemia, is well known, a premonitoring effect of PG in combination with DIC preceding the diagnosis of chronic myelomonocytic leukemia in the same patient has not been reported recently.
Rogalski
Christina
C
Universitätsklinikum Leipzig AöR, Klinik und Poliklinik für Hautkrankheiten, Leipzig, Germany.
Paasch
Uwe
U
Glander
Hans-Jürgen
HJ
Haustein
Uwe-Frithjof
UF
D000284:Administration, Oral; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D047070:Bandages, Hydrocolloid; D003102:Colloids; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007866:Leg; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications*; D011239:Prednisolone / Q000008:administration & dosage; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
D003102:Colloids; D011239:Prednisolone; D001379:Azathioprine