Simplakidine A, a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex.
Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported.
Campagnuolo
Claudio
C
Dipartimento di Chimica delle Sostanze Naturali, Dipartimento di Farmacologia Sperimentale, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy.
Fattorusso
Caterina
C
Fattorusso
Ernesto
E
Ianaro
Angela
A
Pisano
Barbara
B
Taglialatela-Scafati
Orazio
O
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
D000470:Alkaloids; D011726:Pyridinium Compounds; C474590:simplakidine A