Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis.
OBJECTIVE
To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis.


METHODS
Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1 - 4 years after the cessation of therapy.


RESULTS
At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.1%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg.kg(-1).d(-1) for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results.


CONCLUSIONS
AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.
Chai
Junjie
J
Xinjiang Institute for Endemic Diseases Control and Research, Urumqi 830002, China. jchai@xj.cninfo.net
Menghebat
Jiao
Wei
W
Sun
Deyu
D
Liang
Bin
B
Shi
Jincao
J
Fu
Cheng
C
Li
Xiong
X
Mao
Yiding
Y
Wang
Xiuling
X
Dolikun
Guliber
Wang
Yanchun
Y
Gao
Fanghua
F
Xiao
Shuhua
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004655:Emulsions; D015766:Albendazole