Laparoscopic presacral neurolysis for endometriosis-related pelvic pain.
BACKGROUND
Some patients with endometriosis are candidates for sympathectomy of the superior hypogastric plexus. The objective of this paper is to describe our technique of laparoscopic presacral neurolysis for sympathectomy and to report 1 year results of the first 15 cases.


METHODS
To achieve this objective in a prospective observational study of 1 year follow-up; we performed laparoscopic presacral chemical neurolysis with phenol in 15 patients with pelvic pain and minimal-moderate endometriosis. The main outcome measures were: the impact of treatment on pelvic symptom resolution, non-opioid analgesic consumption during menses, sexual performance and observed complications and side effects during 1 year follow-up.


RESULTS
We noted a significant reduction in total pelvic symptom score as compared with baseline mean (SD) of 9.04 (1.2). The mean difference [95% confidence interval (CI)] of reduction was 5.7 (4.9-6.5), 5.8 (5.0-6.6) and 5.8 (4.9-6.6) from the baseline at the 3rd, 6th and 12th postoperative month (P < 0.001). We observed a significant improvement in Sabbatberg Sexual Rating Scale as compared with baseline mean (SD) of 30.9 (4.3). The mean difference (95% CI) of increase was 33.4 (30.3-36.4), 33.2 (30.1-36.2) and 33.2 (30.1-36.3) from the baseline at the 3rd, 6th and 12th postoperative month. We observed a significant reduction in analgesic consumption during menses in terms of total naproxen sodium tablets as compared with baseline mean (SD) of 8.9 (1.1). The mean difference (95% CI) of reduction in the total number of naproxen sodium 250 mg tablets was 6.5 (5.5-7.5), 6.7 (5.7-7.7) and 6.6 (5.6-7.6) from the baseline at the 3rd, 6th and 12th postoperative month. The most common side effect was constipation.


CONCLUSIONS
Laparoscopic presacral neurolysis is feasible and simple. More data is needed to support its efficacy and safety.
Soysal
Mehmet Emin
ME
Department of Obstetrics and Gynecology, Pamukkale University Medical Center, 20100 Denizli, Ankara, Turkey. msoysal@superonline.com
Soysal
Seyide
S
Gurses
Ercan
E
Ozer
Suzan
S
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003075:Coitus; D003248:Constipation / Q000209:etiology; D004715:Endometriosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D010535:Laparoscopy; D008598:Menstruation; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects; D017699:Pelvic Pain / Q000188:drug therapy / Q000209:etiology*; D019800:Phenol / Q000627:therapeutic use; D011446:Prospective Studies; D012445:Sacrococcygeal Region; D012720:Severity of Illness Index; D013563:Sympathectomy, Chemical / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019800:Phenol; D009288:Naproxen