A new stilbene with tyrosinase inhibitory activity from Chlorophora excelsa.
A new stilbene, 4-[(2"E)-7"-hydroxy-3",7"-dimethyloct-2"-enyl]-2',3,4',5-tetrahydroxy-trans-stilbene (1), and the known compound chlorophorin (2) were isolated from the heartwood of Chlorophora excelsa. Both 1 and 2 showed tyrosinase inhibitory activity with IC(50) values of 96 and 1.3 microM, respectively.
Shimizu
Kuniyoshi
K
Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. shimizu@agr.kyushu-u.ac.jp
Yasutake
Seiji
S
Kondo
Ryuichiro
R
D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D029586:Moraceae; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D010455:Peptides; D010936:Plant Extracts; D013267:Stilbenes; D014442:Monophenol Monooxygenase