Nitroglycerin induces hyperalgesia in rats--a time-course study.
Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration. The effect of nitroglycerin on the nociceptive threshold was studied in rats by means of two experimental tests that explore different modalities of pain: the tail-flick test and the formalin test. Nitroglycerin induced a significant reduction in the latency of the tail flick 2 and 4 h after its administration. Similarly, formalin-induced pain-related behaviour increased significantly 2 and 4 h after nitroglycerin administration.
Tassorelli
Cristina
C
Laboratory of Pathophysiology of Integrative Autonomic Systems, University Centre for the Study of Adaptive Disorders and Headache (UCADH), IRCCS C. Mondino Institute of Neurology, Pavia, Italy. cristina.tassorelli@mondino.it
Greco
Rosaria
R
Wang
Dechun
D
Sandrini
Maurizio
M
Sandrini
Giorgio
G
Nappi
Giuseppe
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005557:Formaldehyde; D006930:Hyperalgesia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D005557:Formaldehyde; D005996:Nitroglycerin