title: Ligand-targeted liposomes directed against pathological vasculature.
abstract: The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.
authors.affiliation: Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, TB Utrecht, 3508, The Netherlands.
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Schiffelers
authors.forename: Grietje
authors.initials: G
authors.lastname: Molema
authors.forename: Timo L M
authors.initials: TL
authors.lastname: ten Hagen
authors.forename: Adriënne P C A
authors.initials: AP
authors.lastname: Janssen
authors.forename: Astrid J
authors.initials: AJ
authors.lastname: Schraa
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: Kok
authors.forename: Gerben A
authors.initials: GA
authors.lastname: Koning
authors.forename: Gert
authors.initials: G
authors.lastname: Storm
mesh_terms: D002478:Cells, Cultured; D004317:Doxorubicin / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D007249:Inflammation; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D008024:Ligands; D008081:Liposomes / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D009842:Oligopeptides / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D039302:Integrin alphaVbeta3; D016023:Integrins; D008024:Ligands; D008081:Liposomes; D009842:Oligopeptides; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid; D004317:Doxorubicin