Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells.
Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2 in their T cell polarizing function. In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-alpha and TNF-alpha and a moderate switch in their capacity to polarize naive T cells. Our findings provide an explanation for low levels of type I IFN frequently observed in atopic individuals.
Mazzoni
Alessandra
A
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Leifer
Cynthia A
CA
Mullen
Gregory E D
GE
Kennedy
Margaret N
MN
Klinman
Dennis M
DM
Segal
David M
DM
D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000494:pharmacology; D016898:Interferon-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000378:metabolism; D018664:Interleukin-12 / Q000037:antagonists & inhibitors / Q000378:metabolism; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D010950:Plasma Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000378:metabolism / Q000502:physiology; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism; D014613:Vaccines, Attenuated / Q000494:pharmacology
C408982:CPG-oligonucleotide; D007252:Influenza Vaccines; D016898:Interferon-alpha; D009838:Oligodeoxyribonucleotides; D011970:Receptors, Histamine H2; D014409:Tumor Necrosis Factor-alpha; D014613:Vaccines, Attenuated; D016753:Interleukin-10; D018664:Interleukin-12; D006632:Histamine