14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?
Recent studies suggest that a common theme links the diverse elements of pineal photoneuroendocrine transduction--regulation via binding to 14-3-3 proteins. The elements include photoreception, neurotransmission, signal transduction and the synthesis of melatonin from tryptophan. We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction.
Klein
D C
DC
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development/NIH 49/6A82, Bethesda, MD 20892-4480, USA. klein@helix.nih.gov
Ganguly
S
S
Coon
S L
SL
Shi
Q
Q
Gaildrat
P
P
Morin
F
F
Weller
J L
JL
Obsil
T
T
Hickman
A
A
Dyda
F
F
D048948:14-3-3 Proteins; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000737:chemistry / Q000378:metabolism; D008027:Light; D055537:Light Signal Transduction / Q000502:physiology*; D008550:Melatonin / Q000378:metabolism; D008958:Models, Molecular; D009490:Neurosecretory Systems / Q000378:metabolism*; D009638:Norepinephrine / Q000502:physiology; D010870:Pineal Gland / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014446:Tyrosine 3-Monooxygenase / Q000737:chemistry / Q000145:classification / Q000378:metabolism / Q000502:physiology* / Q000528:radiation effects
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin; D009638:Norepinephrine