Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines.
6-Alkynyl- and 6-alkenylpurines have been screened for cytotoxic activity against a human chronic myelogenous leukemia cell line; K-562 cells using a [(3)H]-thymidine incorporation assay. Most alkynes displayed cytotoxicity comparable to, or better than, the known anticancer drugs 6-mercaptopurine and fludarabine. The 6-alkenylpurines, which are promising plant growth stimulators and 15-lipoxygenase inhibitors, exhibited only low toxicity.
Bråthe
Anders
A
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Gundersen
Lise-Lotte
LL
Nissen-Meyer
Jon
J
Rise
Frode
F
Spilsberg
Bjørn
B
D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D011687:Purines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000480:Alkynes; D000970:Antineoplastic Agents; D011687:Purines