Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives.
A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-[4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene]thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.
Kim
Bok Young
BY
New Drug Research Laboratories, Chong Kun Dang Research Institute, Cheonan, South Korea.
Ahn
Joong Bok
JB
Lee
Hong Woo
HW
Moon
Kyoung Sik
KS
Sim
Tae Bo
TB
Shin
Jae Soo
JS
Ahn
Soon Kil
SK
Hong
Chung Il
CI
D000818:Animals; D002478:Cells, Cultured; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012266:Ribose / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013780:Tetroses / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D045162:Thiazolidinediones
D007004:Hypoglycemic Agents; D011759:Pyrrolidines; D013780:Tetroses; D013844:Thiazoles; D045162:Thiazolidinediones; D012266:Ribose; C089946:2,4-thiazolidinedione; C032519:pyrrolidine; C073321:erythrose