Herpes zoster virus sclerokeratitis and anterior uveitis in a child following varicella vaccination.
OBJECTIVE
To report a case of herpes zoster virus sclerokeratitis with anterior uveitis following vaccination with live attenuated varicella vaccine (Oka strain).


METHODS
Case report.


METHODS
The case records of the patient were reviewed retrospectively. Pertinent literature citations were identified using MEDLINE.


RESULTS
A 9-year-old boy presented with herpes zoster ophthalmicus 3 years following vaccination with live attenuated varicella vaccine (Oka strain). Examination of the affected eye revealed a moderate follicular response on the palpebral conjunctiva, decreased corneal sensation, mildly elevated intraocular pressure, diffuse anterior scleritis with marginal keratitis, and a moderately severe anterior uveitis. Amplified DNA from fluid taken from the base of a cutaneous vesicle produced wild-type varicella zoster virus (VZV) DNA, not Oka strain.


CONCLUSIONS
Herpes zoster virus infection needs to be considered in all patients who present with scleritis, keratitis, or anterior uveitis, regardless of their varicella vaccination status.
Naseri
Ayman
A
Francis I. Proctor Foundation and Department of Ophthalmology, University of California at San Francisco Medical Center, San Francisco, California, USA.
Good
William V
WV
Cunningham
Emmett T
ET
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D019433:Chickenpox Vaccine / Q000009:adverse effects* / Q000235:genetics; D002648:Child; D003519:Cyclopentolate / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D006563:Herpes Zoster Ophthalmicus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D020433:Trigeminal Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014611:Vaccination / Q000009:adverse effects
D000998:Antiviral Agents; D019433:Chickenpox Vaccine; D004279:DNA, Viral; D005938:Glucocorticoids; C009935:prednisolone acetate; D011239:Prednisolone; D003519:Cyclopentolate; D000212:Acyclovir