Quantitative measurements of proton spin-lattice (T1) and spin-spin (T2) relaxation times in the mouse brain at 7.0 T.
The goal of this work is to provide regional T(1) and T(2) values at a field strength of 7 T for the normal mouse brain at 6 weeks and 1 year old. A novel segmented snapshot FLASH sequence was used to measure T(1) in the hippocampus, corpus callosum, and the retrosplenial granular (RSG) cortex; T(2) measurements were made in the same regions using a single spin echo sequence repeated at six separate echo times. Both T(1) and T(2) measurements were validated with phantom measurements.
Guilfoyle
David N
DN
Nathan S. Kline Institute, Center for Advanced Brain Imaging, Orangeburg, New York 10962, USA.
Dyakin
Victor V
VV
O'Shea
Jacqueline
J
Pell
Gaby S
GS
Helpern
Joseph A
JA
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D017352:Echo-Planar Imaging / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D008815:Mice, Inbred Strains; D019047:Phantoms, Imaging; D011522:Protons
D011522:Protons