title: Influence of Escherichia coli endotoxin-induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats.
abstract: The pharmacokinetic behavior of marbofloxacin was studied in seven healthy goats and in the same goats with induced fever after single-dose intravenous (i.v.) administration of 2 mg/kg b.w. Fever was induced by the administration of Escherichia coli endotoxin. Drug concentration in plasma was determined by high-performance liquid chromatography (HPLC). Drug distribution was somehow altered by fever as febrile goats showed a volume of distribution at steady-state (Vss = 0.72 +/- 0.15 L/kg) lower than normal goats (Vss = 1.19 +/- 0.33 L/kg). The elimination of the drug was also modified. Total plasma clearance (Cl) decreased from 0.24 +/- 0.12 L/kg/h in healthy animals to 0.13 +/- 0.05 L/kg/h in animals with endotoxin-induced fever, which is related to an increase in the area under the plasma concentration-time curve (AUC). Consequently, mean residence time (MRT) was also slightly increased in sick animals (MRT = 5.28 +/- 00.99 and 6.09 +/- 01.45 h, in healthy and febrile animals, respectively).
authors.affiliation: Department of Pharmacology, Veterinary Sciences Faculty, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Waxman
authors.forename: M D
authors.initials: MD
authors.lastname: San Andrés
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: J J
authors.initials: JJ
authors.lastname: De Lucas
authors.forename: M I
authors.initials: MI
authors.lastname: San Andrés
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D005334:Fever / Q000378:metabolism / Q000662:veterinary*; D024841:Fluoroquinolones; D015511:Goat Diseases / Q000378:metabolism*; D006041:Goats / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D015363:Quinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D059005:Topoisomerase II Inhibitors
chemical_list: D000890:Anti-Infective Agents; D004731:Endotoxins; D024841:Fluoroquinolones; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; C080260:marbofloxacin