Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study.
OBJECTIVE
The authors examined possible cerebral gray matter abnormalities in patients with panic disorder.


METHODS
Gray matter concentration in 18 panic disorder outpatients and 18 healthy subjects was compared by using a voxel-based morphometry approach.


RESULTS
Gray matter density of the left parahippocampal gyrus was significantly lower in patients with panic disorder compared with healthy subjects.


CONCLUSIONS
This result provides further support for the involvement of the parahippocampal area in the pathophysiology of panic disorder.
Massana
Guillem
G
Institut Clínic de Psiquiatria i Psicologia, Corporació Sanitària Clínic, I.D.I.B.A.S., Barcelona, Catalonia, Spain. trocosmos@yahoo.es
Serra-Grabulosa
Josep Maria
JM
Salgado-Pineda
Pilar
P
Gastó
Cristòbal
C
Junqué
Carme
C
Massana
Joan
J
Mercader
José María
JM
D000328:Adult; D000379:Agoraphobia / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D016584:Panic Disorder / Q000175:diagnosis* / Q000503:physiopathology; D020534:Parahippocampal Gyrus / Q000033:anatomy & histology* / Q000503:physiopathology