title: Relationship between bone mineral density and angiotensin converting enzyme polymorphism in hypertensive postmenopausal women.
abstract: BACKGROUND
  The purpose of this study was to assess the relationship between bone mineral density and insertion/deletion (I/D) angiotensin converting enzyme polymorphism (ACE) in hypertensive postmenopausal women.
  
  
  METHODS
  Blood and urine samples from the study subjects were analyzed for calcium metabolism related parameters. Densitometry studies were conducted in the lumbar spine (L2 to L4). The ACE polymorphism was analyzed by polymerase chain reaction.
  
  
  RESULTS
  Women with II genotype showed a higher intact parathyroid hormone (76 +/- 33 v 55 +/- 27 pg/mL and 52 +/- 26 pg/mL, P =.034) without a decrease in calciuria, and higher bone mineral density than women with ID and homozygotus deletion genotype (1.138 +/- 0.08 v 1.051 +/- 0.16 pg/mL and 1.053 +/- 0.16 pg/mL).
  
  
  CONCLUSIONS
  The ACE polymorphism could be one of the factors causing bone mass variations.
authors.affiliation: Departamento Medicina Interna, Hospital Universitario Río Hortega, Facultad de Medicina, Valladolid, Spain. castrv@terra.es
authors.forename: José Luis
authors.initials: JL
authors.lastname: Pérez-Castrillón
authors.forename: Isabel
authors.initials: I
authors.lastname: Justo
authors.forename: Jesús
authors.initials: J
authors.lastname: Silva
authors.forename: Alberto
authors.initials: A
authors.lastname: Sanz
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martín-Escudero
authors.forename: Rosa
authors.initials: R
authors.lastname: Igea
authors.forename: Pilar
authors.initials: P
authors.lastname: Escudero
authors.forename: Carol
authors.initials: C
authors.lastname: Pueyo
authors.forename: Cristina
authors.initials: C
authors.lastname: Diaz
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hernández
authors.forename: Antonio
authors.initials: A
authors.lastname: Dueñas
mesh_terms: D000328:Adult; D015519:Bone Density / Q000235:genetics*; D002118:Calcium / Q000097:blood / Q000652:urine; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause
chemical_list: D007703:Peptidyl-Dipeptidase A; D002118:Calcium