The coalescent and infinite-site model of a small multigene family.
The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.
Innan
Hideki
H
Department of Biological Science, University of Southern California, Los Angeles, California 90089-1340, USA. hinnan@sph.uth.tmc.edu
D003627:Data Interpretation, Statistical; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D005810:Multigene Family; D011110:Polymorphism, Genetic