Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation.
Inflammation is a complex multifactorial process and a hallmark of many inflammatory diseases. Most of the tissue destruction that occurs in these diseases is the result of an aberrant or often uncontrolled immune response. Factors that play an important role in such diseases include pro-inflammatory cytokines, complement, and eicosanoids. This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be targeted as a new therapeutic tool to control inflammatory diseases.
Ribardo
Deborah A
DA
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX 77555-1070, USA.
Peterson
Johnny W
JW
Chopra
Ashok K
AK
D000818:Animals; D051546:Cyclooxygenase 2; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D008555:Melitten / Q000378:metabolism; D008565:Membrane Proteins; D008954:Models, Biological; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007527:Isoenzymes; D008565:Membrane Proteins; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; C055324:phospholipase A2-activating protein; D008555:Melitten; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases