title: Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
abstract: Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell proliferation assay.
authors.affiliation: Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakeya
authors.forename: Naoko
authors.initials: N
authors.lastname: Takahashi-Ando
authors.forename: Makoto
authors.initials: M
authors.lastname: Kimura
authors.forename: Rie
authors.initials: R
authors.lastname: Onose
authors.forename: Isamu
authors.initials: I
authors.lastname: Yamaguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D001203:Ascomycota / Q000145:classification* / Q000378:metabolism*; D001711:Biotransformation; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007659:Ketones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012118:Resorcinols / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015025:Zearalenone / Q000378:metabolism*
chemical_list: C476266:1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'-undecene-6'-one; D004967:Estrogens; D007659:Ketones; D012118:Resorcinols; D015025:Zearalenone