Hypersensitivity to efavirenz treated with corticosteroids in a 6-year-old child.
We report a case of the successful use of corticosteroids to treat hypersensitivity caused by efavirenz in a pediatric patient. A 6-year-old HIV-infected patient developed a diffuse erythematous rash and fever after being switched to a regimen containing efavirenz. Use of prednisone at a dose of 1 mg/kg every other day for 2 weeks on rechallenge resulted in successful reinstitution of the regimen.
Foti
Jeffrey L
JL
Bill Holt Pediatric Infectious Disease Clinic, Phoenix Children's Hospital, Phoenix, Arizona 85016, USA. jfoti@phoenixchildrens.com
Piatt
Janice P
JP
D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects*; D048588:Benzoxazines; D002648:Child; D003521:Cyclopropanes; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000209:etiology; D010078:Oxazines / Q000009:adverse effects*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz; D011241:Prednisone