title: Lack of anti-D in women at birth following antepartum immune globulin prophylaxis.
abstract: Antepartum prophylaxis using Rh immune globulin suppresses maternal immunization to transplacental transfer of Rh-positive fetal cells, and, theoretically, to be effective, anti-D should be detectable until birth. We used a sensitive gel technique to quantitatively detect the serum concentration of anti-D at birth in 150 women who had received 300 microg of Rh immune globulin at 28 weeks gestation. Our method, which was sensitive enough to detect 20-25 microg, the recommended residual amount at birth, was positive in only 21% total, and in only 13% of women at term. Fifty-seven percent of women with premature births had above the recommended level of anti-D.
authors.affiliation: Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Jerusalem 91031, Israel. rudensky@szm.org.il
authors.forename: Bernard
authors.initials: B
authors.lastname: Rudensky
authors.forename: Eyal
authors.initials: E
authors.lastname: Mazaki
authors.forename: Mira
authors.initials: M
authors.lastname: Na'amad
authors.forename: Arnon
authors.initials: A
authors.lastname: Samueloff
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007752:Obstetric Labor, Premature; D036801:Parturition; D011247:Pregnancy; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage* / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D007518:Isoantibodies; C033242:RH-antibodies; D018029:Rho(D) Immune Globulin