title: Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intrathecal vancomycin in an allogeneic peripheral blood stem cell transplant recipient.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a common infectious pathogen during stem cell trans-plantation. We report a case of meningoencephalitis with multiple abscess formation caused by MRSA, which occurred in a 4-year-old boy soon after allogeneic peripheral blood stem cell transplantation. We successfully cured the infection with a combination of intravenous and intrathecal vancomycin.
authors.affiliation: Divisions of Pediatric Oncology, National Cancer Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.forename: A
authors.initials: A
authors.lastname: Makimoto
authors.forename: T
authors.initials: T
authors.lastname: Higa
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kanda
authors.forename: M
authors.initials: M
authors.lastname: Kami
authors.forename: R
authors.initials: R
authors.lastname: Tanosaki
authors.forename: S
authors.initials: S
authors.lastname: Mineishi
authors.forename: M
authors.initials: M
authors.lastname: Ohira
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D016106:Methicillin Resistance; D016609:Neoplasms, Second Primary / Q000628:therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D013211:Staphylococcus aureus; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin