Nitric oxide in liver inflammation and regeneration.
Hepatocytes express and release inflammatory mediators after challenge with bacterial cell wall molecules and proinflammatory cytokines. Nitric oxide synthase-2 (NOS-2) is expressed under these conditions and the high-output NO synthesis that follows contributes to the inflammatory response in this tissue and participates in the onset of several hepatopathies. However, in the course of liver regeneration, for example, after partial hepatectomy, NOS-2 is expressed at moderate levels and contributes to inhibit apoptosis and to favor progression in the cell cycle until the organ size and function are restored. The mechanisms involved in the regulation of NOS-2 expression under these conditions are revised.
Martin-Sanz
Paloma
P
Instituto de Bioquímica (Centro Mixto CSIC-UCM), Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Hortelano
Sonsoles
S
Callejas
Nuria A
NA
Goren
Nora
N
Casado
Marta
M
Zeini
Miriam
M
Boscá
Lisardo
L
D000818:Animals; D006498:Hepatectomy / Q000379:methods; D006505:Hepatitis / Q000378:metabolism*; D008115:Liver Regeneration / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*
D009569:Nitric Oxide