title: The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study.
abstract: Several studies have shown a role for interleukin-1 gene cluster polymorphisms in the risk assessment for periodontal diseases. In the Study of Health in Pomerania (SHIP), 3148 subjects were randomly selected from the population and assessed for a broad range of diseases and environmental/behavioral risk factors. From the complete study group in the age 40 to 60 years, N = 1085 subjects were genotyped for the interleukin-1 genotype composite polymorphism in relation to periodontal parameters. The study objective was to elucidate the gene-environment interaction between the risk factors smoking and IL-1 polymorphism. An increased risk of periodontal disease was found for IL-1 genotype-positive smokers: odds ratio adjusted for age, sex, education, and plaque OR = 2.50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis.
authors.affiliation: Department of Pharmacology, Ernst Moritz Arndt University, F-Loeffler-Str. 23d, D-17487 Greifswald, Germany. meiselp@uni-greifswald.de
authors.forename: P
authors.initials: P
authors.lastname: Meisel
authors.forename: A
authors.initials: A
authors.lastname: Siegemund
authors.forename: R
authors.initials: R
authors.lastname: Grimm
authors.forename: F H
authors.initials: FH
authors.lastname: Herrmann
authors.forename: U
authors.initials: U
authors.lastname: John
authors.forename: C
authors.initials: C
authors.lastname: Schwahn
authors.forename: T
authors.initials: T
authors.lastname: Kocher
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010518:Periodontitis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012494:Sampling Studies; D012907:Smoking / Q000009:adverse effects*
chemical_list: D007375:Interleukin-1