title: Evaluation of 18F-FDG PET with bladder irrigation in patients with uterine and ovarian tumors.
abstract: The purpose of this study was to evaluate PET using (18)F-FDG for gynecologic lesions with continuous bladder irrigation to eliminate artifacts from the (18)F-FDG activity in the bladder.
  
  
  METHODS
  Forty-one patients were studied. They had 23 cervical uterine lesions (15 cases of cancer, 5 recurrences, 3 nonrecurrences); 8 cases of uterine corpus cancer, including 2 recurrences; and 10 ovarian masses (6 malignant, 4 nonmalignant). All cases of cancer were histologically proven; however, 2 cases of nonrecurrent uterine cervical carcinomas were diagnosed by clinical course. Continuous bladder irrigation was performed 35-55 min after intravenous administration of 185-370 MBq (18)F-FDG, and an emission scan was obtained 40-55 min after intravenous administration. Standardized uptake value (SUV) was used to estimate the degree of (18)F-FDG uptake quantitatively.
  
  
  RESULTS
  After bladder irrigation, the (18)F-FDG activity in the urinary tract was eliminated in 33 patients, so that detection of tumor (18)F-FDG accumulation was easy. Two patients showed residual activity in the urinary bladder, and 6 patients showed activity in the ureter. An artifact was seen in 1 patient with residual activity in the urinary bladder caused by insufficient irrigation. However, these residual activities had no influence on detecting (18)F-FDG accumulation in tumor. The mean (+/-SD) of SUVs of malignant lesions was 6.04 +/- 3.22, that of nonmalignant lesions was 1.71 +/- 1.12, and the difference was significant (P = 0.0002). SUVs of all malignant lesions were greater than 2.0, and SUVs of all nonmalignant lesions, except the 1 case of ovarian fibroma, were less than 2.0.
  
  
  CONCLUSIONS
  (18)F-FDG PET with continuous bladder irrigation is useful for eliminating (18)F-FDG activity in the bladder and for differentiating between malignant and nonmalignant uterine or ovarian masses.
authors.affiliation: Department of Radiology, Osaka City University School of Medicine, Osaka, Japan. koichikoyamats@yahoo.com
authors.forename: Koichi
authors.initials: K
authors.lastname: Koyama
authors.forename: Terue
authors.initials: T
authors.lastname: Okamura
authors.forename: Joji
authors.initials: J
authors.lastname: Kawabe
authors.forename: Nozomi
authors.initials: N
authors.lastname: Ozawa
authors.forename: Kenzi
authors.initials: K
authors.lastname: Torii
authors.forename: Naohiko
authors.initials: N
authors.lastname: Umesaki
authors.forename: Masato
authors.initials: M
authors.lastname: Miyama
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ochi
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D002277:Carcinoma / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D007507:Therapeutic Irrigation; D014055:Tomography, Emission-Computed; D001743:Urinary Bladder / Q000000981:diagnostic imaging*; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18