Two signal models of lymphocyte activation incorporate a mechanism of peripheral tolerance, and have implications for achieving immunological unresponsiveness and effective transplantation.
Bretscher
Peter
P
Department of Microbiology and Immunology, University of Saskatchewan, Saskatchewan, Canada. bretschr@duke.usask.ca
Peters
Nathan
N
D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000276:immunology*; D017634:Self Tolerance; D015398:Signal Transduction / Q000276:immunology; D023001:Transplantation Tolerance