title: [Biochemical parameters of connective tissue in diagnosis of the initial stage of liver cirrhosis].
abstract: Hepatocirrhosis is an independent progressing disease of the hepatic connective tissue. It is characterized biochemically at all stages (i.e. compensation, subcompensation and decompensation) by low indices of free oxyproline, of total cholesterol and glycoproteins; simultaneously, it is described by a high level of glycosaminoglycanes. A low content of serum non-hemin iron was also pointed out. An early diagnosis of hepatocirrhosis at the initial stage is important for a correct and timely choice of treatment aimed at recovering the patients or prolonging their lives.
authors.forename: V I
authors.initials: VI
authors.lastname: Bychkova
authors.forename: B M
authors.initials: BM
authors.lastname: Smirnov
authors.forename: L V
authors.initials: LV
authors.lastname: Lesnichuk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006025:Glycosaminoglycans / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000150:complications; D006801:Humans; D006909:Hydroxyproline / Q000097:blood; D007501:Iron / Q000097:blood; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D006025:Glycosaminoglycans; D002784:Cholesterol; D007501:Iron; D006909:Hydroxyproline