Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity.
Anti MDR activity of a series of acridine, pyridoquinoline, quinoline and pyridine analogous amines was evaluated. Interesting activity is displayed by tricyclic compounds. Besides ring size, influence of the side chain was studied.
Gallo
Sandrine
S
GERCTOP-UMR CNRS 6009, faculté de pharmacie, Université de la Méditerranée, 27, bd Jean Moulin, 13385 Marseille cedex 05, France.
Atifi
Siham
S
Mahamoud
Abdallah
A
Santelli-Rouvier
Christiane
C
Wolfárt
Krisztina
K
Molnar
Jozsef
J
Barbe
Jacques
J
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D005456:Fluorescent Dyes; D007940:Leukemia L5178; D051379:Mice; D008956:Models, Chemical; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D020112:Rhodamine 123; D013329:Structure-Activity Relationship
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000166:Acridines; D001372:Aza Compounds; D005456:Fluorescent Dyes; D011725:Pyridines; D011804:Quinolines; D020112:Rhodamine 123