title: The effect of chlorhexidine gluconate as an endodontic irrigant on the apical seal: long-term results.
abstract: The purpose of this study was to determine whether chlorhexidine gluconate (0.12%), used as an endodontic irrigating solution, would affect the apical seal of three root canal cements. One hundred, extracted, human, single-canal teeth were divided into 9 experimental groups of 10 teeth each, in addition to a positive and negative control group of 5 teeth each. The teeth were decoronated at the level of the CEJ, accessed, instrumented to a Master apical file #50, irrigated with either sterile saline, 5.25% NaOCl, or 0.12% chlorhexidine gluconate, and dried using paper points. Obturation was accomplished using lateral condensation and one of three endodontic sealers: Roth's 811, AH 26, or Sealapex. Postobturation apical leakage was measured at 270- and 360-day observation periods using the fluid filtration method. Using the mixed-model repeated-measures ANOVA test with Tukey's honest significance difference multiple comparison procedure, the results showed the saline-Sealapex combination had significantly more leakage (p < 0.05) than either the Peridex-Sealapex or saline-Roth's combinations at 270 days. No other significant differences were noted between any sealer-irrigant combination at 270 days. The saline-Sealapex combination had significantly more leakage than the saline-Roth's combination at 360 days. No other significant differences were noted at 360 days. Under the conditions of this study, chlorhexidine gluconate irrigant did not adversely affect the apical seal of three root canal cements at 270 and 360 days.
authors.affiliation: Graduate Endodontic Program, 618th Dental Company, Seoul, Korea.
authors.forename: David B
authors.initials: DB
authors.lastname: Ferguson
authors.forename: John T
authors.initials: JT
authors.lastname: Marley
authors.forename: Gary R
authors.initials: GR
authors.lastname: Hartwell
mesh_terms: D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D001729:Bismuth; D002126:Calcium Hydroxide; D002710:Chlorhexidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003763:Dental Leakage / Q000209:etiology*; D004338:Drug Combinations; D004853:Epoxy Resins; D006171:Gutta-Percha; D006801:Humans; D008422:Materials Testing; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants / Q000009:adverse effects*; D012459:Salicylates; D012834:Silver; D012973:Sodium Hypochlorite / Q000009:adverse effects; D018709:Statistics, Nonparametric; D014025:Titanium; D019227:Tooth Apex / Q000187:drug effects*; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D004853:Epoxy Resins; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D012459:Salicylates; D015035:Zinc Oxide-Eugenol Cement; C055601:Sealapex; D012834:Silver; C028044:epoxy resin AH-26; C095719:Roth's 811 sealer; D006171:Gutta-Percha; D014025:Titanium; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002126:Calcium Hydroxide; D002710:Chlorhexidine; D001729:Bismuth