Interaction of binuclear xylylthiolato(2,2',2"-terpyridine)platinum(II) complexes with DNA.
The new binuclear platinum(II) complexes, (1,3-benzenedimethanethiolate-S)di(2,2',2"-terpyridine)diplatinum(II) chloride tetrahydrate, 5, and (1,4-benzenedimethanethiolate-S)di(2,2',2"-terpyridine)diplatinum(II) chloride tetrahydrate, 6, were synthesized in order to investigate the binding of platinum(II) complex with calf thymus DNA, which was examined by UV and CD spectroscopies. Complex 5 interacted strongly with DNA by intercalation compared to 6.
Kurosaki
Hiromasa
H
Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Yamakawa
Naoki
N
Sumimoto
Masamitsu
M
Kimura
Kana
K
Goto
Masafumi
M
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D006358:Hot Temperature; D007364:Intercalating Agents / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D018736:DNA Adducts; D007364:Intercalating Agents; D009944:Organoplatinum Compounds; D011725:Pyridines; D004247:DNA; C427203:calf thymus DNA