title: Computing oxygen-enhanced ventilation maps using correlation analysis.
abstract: Correlation maps of oxygen-enhanced ventilation were obtained in nine healthy volunteers using complete and selected image series. The complete series included all images acquired with the subjects alternately inhaling room air and 100% oxygen. The selected series were the subsets of the complete series and included only co-registered images that showed matched diaphragmatic position at maximal expiration. Cross-correlation was computed between the time response function of each pixel and the input function representing the alternation between periods of room air and 100% oxygen inhalation. The confidence level for the correlation analysis was set to 0.01. Pulmonary parenchymal anatomy was consistently reproduced throughout the lung, even in anterior slices where published data have reported correlation problems. The overall average correlation coefficient was 0.66 +/- 0.07 for the complete series and 0.75 +/- 0.08 for the selected series. It was concluded that correlation analysis could be used to reconstruct qualitative oxygen-enhanced ventilation maps.
authors.affiliation: Department of Radiology, Evanston Hospital, Evanston Northwestern Healthcare, Illinois 60201, USA. vmai@enh.org
authors.forename: Vu M
authors.initials: VM
authors.lastname: Mai
authors.forename: Sean
authors.initials: S
authors.lastname: Tutton
authors.forename: Pottumarthi V
authors.initials: PV
authors.lastname: Prasad
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Chi
authors.initials: C
authors.lastname: Chen
authors.forename: Benjamin
authors.initials: B
authors.lastname: Liu
authors.forename: Jason
authors.initials: J
authors.lastname: Polzin
authors.forename: Saban
authors.initials: S
authors.lastname: Kurucay
authors.forename: Robert R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003964:Diaphragm / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage; D012123:Pulmonary Ventilation / Q000502:physiology*
chemical_list: D010100:Oxygen