Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents.
[formula: see text] The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxilliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.
Bream
Robert N
RN
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Ley
Steven V
SV
Procopiou
Panayiotis A
PA