title: Infrared imaging of 2-D temperature distribution during cryogen spray cooling.
abstract: Cryogen spray cooling (CSC) is used in conjunction with pulsed laser irradiation for treatment of dermatologic indications. The main goal of this study was to determine the radial temperature distribution created by CSC and evaluate the importance of radial temperature gradients upon the subsequent analysis of tissue cooling throughout the skin. Since direct measurement of surface temperatures during CSC are hindered by the formation of a liquid cryogen layer, temperature distributions were estimated using a thin, black aluminum sheet. An infrared focal plane array camera was used to determine the 2-D backside temperature distribution during a cryogen spurt, which preliminary measurements have shown is a good indicator of the front-side temperature distribution. The measured temperature distribution was approximately gaussian in shape. Next, the transient temperature distributions in skin were calculated for two cases: 1) the standard 1-D solution which assumes a uniform cooling temperature distribution, and 2) a 2-D solution using a nonuniform surface cooling temperature distribution based upon the back-side infrared temperature measurements. At the end of a 100-ms cryogen spurt, calculations showed that, for the two cases, large discrepancies in temperatures at the surface and at a 60-micron depth were found at radii greater than 2.5 mm. These results suggest that it is necessary to consider radial temperature gradients during cryogen spray cooling of tissue.
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA. bchoi@laser.bli.uci.edu
authors.forename: Bernard
authors.initials: B
authors.lastname: Choi
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Welch
mesh_terms: D000335:Aerosol Propellants / Q000008:administration & dosage*; D003080:Cold Temperature; D003198:Computer Simulation; D017679:Cryotherapy / Q000379:methods; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D017075:Laser Coagulation / Q000379:methods; D028022:Low-Level Light Therapy / Q000379:methods; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012881:Skin Temperature / Q000502:physiology*; D013696:Temperature; D013817:Thermography / Q000379:methods*
chemical_list: D000335:Aerosol Propellants