Cancer "photo-chemoprevention" with pulsed dye laser and celecoxib.
OBJECTIVE
Our previous study demonstrated the efficacy of pulsed dye laser (PDL) in inhibiting cancer growth. This study is to determine the synergic effect of PDL and Celecoxib, when they are combined for treatment of oral cancer.


METHODS
Fifteen mice were inoculated with oral cell carcinoma and divided into three groups of five each (30 seeding sites/group): (1) control (no treatment), (2) PDL only, and (3) treatment with combined PDL and Celecoxib (1,500 ppm). The number and volume of tumors were counted and measured for 21 days.


RESULTS
The combined treatment developed tumor at the slowest rate. On day 21, the average tumor volumes were (1) 483.6 mm(3) (control), (2) 312.1 mm(3) (PDL only), and (3) 151.4 mm(3) (combined treatment).


CONCLUSIONS
A synergic effect was found in the combined treatment group. This study provides the first evidence of the efficacy of a new strategy for the treatment of oral cancer, namely, cancer "photo-chemoprevention."
Wang
Zhi
Z
Department of Otolaryngology Head and Neck Surgery, Boston Medical Center/Boston University School of Medicine, Massachusetts 02118, USA. zwang@bu.edu
Fuentes
Cesar F
CF
Shapshay
Stanley M
SM
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D000068579:Celecoxib; D018890:Chemoprevention / Q000379:methods; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D053685:Laser Therapy; D051379:Mice; D008819:Mice, Nude; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D011336:Probability; D011720:Pyrazoles; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D013449:Sulfonamides / Q000494:pharmacology*; D016896:Treatment Outcome
D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib