title: The balance between pleiotropic mutation and selection, when alleles have discrete effects.
abstract: The theory of pleiotropic mutation and selection is investigated and developed for a large population of asexual organisms. Members of the population are subject to stabilising selection on Omega phenotypic characters, which each independently affect fitness. Pleiotropy is incorporated into the model by allowing each mutation to simultaneously affect all characters. To expose differences with continuous-allele models, the characters are taken to originate from discrete-effect alleles and thus have discrete genotypic effects. Each character can take the values nxDelta where n=0,+/-1,+/-2, em leader, and the splitting in character effects, Delta, is a parameter of the model. When the distribution of mutant effects is normally distributed around the parental value, and Delta is large, a "stepwise" model of mutation arises, where only adjacent trait effects are accessible from a single mutation. The present work is primarily concerned with the opposite limit, where Delta is small and many different trait effects are accessible from a single mutation. In contrast to what has been established for continuous-effect models, discrete-effect models do not yield a singular equilibrium distribution of genotypic effects for any value of Omega. Instead, for different values of Omega, the equilibrium frequencies of trait values have very different dependencies on Delta. For Omega=1 and 2, decreasing Delta broadens the width of the frequency distribution and hence increases the equilibrium level of polymorphism. For all sufficiently large values of Omega, however, decreasing Delta decreases the width of the frequency distribution and the equilibrium level of polymorphism. The connection with continuous trait models follows when the limit Delta-->0 is considered, and a singular probability density of trait values is obtained for all sufficiently large Omega.
authors.affiliation: Centre for the Study of Evolution, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, Sussex, UK. d.waxman@sussex.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Waxman
mesh_terms: D000483:Alleles; D000818:Animals; D005828:Genetics, Population; D006238:Haploidy; D008957:Models, Genetic; D009154:Mutation; D012100:Reproduction, Asexual; D012641:Selection, Genetic; D006113:United Kingdom