title: The coalescent and infinite-site model of a small multigene family.
abstract: The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.
authors.affiliation: Department of Biological Science, University of Southern California, Los Angeles, California 90089-1340, USA. hinnan@sph.uth.tmc.edu
authors.forename: Hideki
authors.initials: H
authors.lastname: Innan
mesh_terms: D003627:Data Interpretation, Statistical; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D005810:Multigene Family; D011110:Polymorphism, Genetic