title: RNA sequences that work as transcriptional activating regions.
abstract: We describe a set of RNA molecules that work as transcriptional activators when tethered to DNA. These RNA activating regions were found amongst a randomized set of molecules bearing variants of a 10 nt loop attached to an RNA stem. The various RNA activating regions all bear an identical five- residue sequence with an interspersed sixth residue. The result shows that although all natural activating regions characterized thus far are peptidic, this function can be served by other kinds of moieties as well.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Shamol
authors.initials: S
authors.lastname: Saha
authors.forename: Aseem Z
authors.initials: AZ
authors.lastname: Ansari
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Jarrell
authors.forename: Mark
authors.initials: M
authors.lastname: Ptashne
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Jarell
mesh_terms: D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000235:genetics; D012313:RNA / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015533:Transcriptional Activation / Q000235:genetics*
chemical_list: D009843:Oligoribonucleotides; D012313:RNA