Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity.
Through its production of cyclic adenosine diphosphate ribose, the ecto-enzyme CD38 regulates calcium mobilization in neutrophils responding to some, but not all, chemoattractants. This signaling defect results in reduced chemotaxis of CD38-deficient neutrophils to bacterial peptides and increased susceptibility of CD38-deficient mice to bacterial infections.
Partida-Sánchez
Santiago
S
Trudeau Institute, PO Box 59, Saranac Lake, NY 12983, USA.
Randall
Troy D
TD
Lund
Frances E
FE
D036541:ADP-ribosyl Cyclase / Q000172:deficiency / Q000378:metabolism* / Q000502:physiology*; D051997:ADP-ribosyl Cyclase 1; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism* / Q000502:physiology*; D001424:Bacterial Infections / Q000201:enzymology / Q000276:immunology*; D001854:Bone Marrow Cells / Q000201:enzymology; D002118:Calcium / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000473:pathology; D008562:Membrane Glycoproteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
D015703:Antigens, CD; D016207:Cytokines; D008562:Membrane Glycoproteins; D036541:ADP-ribosyl Cyclase; C498155:Cd38 protein, mouse; D051997:ADP-ribosyl Cyclase 1; D002118:Calcium