title: [Preimplantation genetic diagnosis: two successful cases]
abstract: OBJECTIVE: To establish a technology of preimplantation genetic diagnosis. METHODS: Intracytoplasm sperm injection and blastomere biopsy were performed on two women at the advanced age with the fallopian tube obstruction. Normal embryos were selected for embryo transfer after fluorescence in-situ hybridziation in biopsied blastomere. RESULTS: The levels of serum HCG were increased 20 days after embryo transfer and ultrasonography in 16 gestation weeks showed the fetal growth and structure are normal. CONCLUSION: Two successful clinical pregnancies achieved after preimplantation genetic diagnosis.
authors.affiliation: The Affiliated Obstetrics and Gynecology Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
authors.forename: Chen-Ming
authors.initials: CM
authors.lastname: Xu
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Gao
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Qian
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Ye
authors.forename: Fu-Zhen
authors.initials: FZ
authors.lastname: Zhou
authors.forename: He-Feng
authors.initials: HF
authors.lastname: Huang