title: Exposure to soil contaminated with an environmental PCB/PCDD/PCDF mixture modulates ultraviolet radiation-induced non-melanoma skin carcinogenesis in the Crl:SKH1-hrBR hairless mouse.
abstract: Chlorinated aromatic contaminants are active in carcinogenic processes within the skin and may have the potential to modulate ultraviolet radiation (UV)-induced skin carcinogenesis. Exposure to a complex environmental PCB/PCDD/PCDF mixture (polychlorinated biphenyls/polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans) during the irradiation phase of photocarcinogenesis was associated with significant (P < or = 0.001) reductions in papilloma incidence and squamous cell carcinoma multiplicity at irradiated skin sites. This protective effect was associated with significantly (P < 0.0001) reduced chronic epidermal thickening in UV and contaminant-exposed mice compared with mice exposed to UV only. Contaminant exposure was also associated with increased UV absorbance of skin methanol extracts implying a sunscreen-like effect.
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331-4804, USA. rhian.cope@osu.edu
authors.forename: Rhian B
authors.initials: RB
authors.lastname: Cope
authors.forename: Kanjana
authors.initials: K
authors.lastname: Imsilp
authors.forename: Carla K
authors.initials: CK
authors.lastname: Morrow
authors.forename: Jim
authors.initials: J
authors.lastname: Hartman
authors.forename: David J
authors.initials: DJ
authors.lastname: Schaeffer
authors.forename: Larry G
authors.initials: LG
authors.lastname: Hansen
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000627:therapeutic use*; D005260:Female; D000432:Methanol / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D010212:Papilloma / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D011078:Polychlorinated Biphenyls / Q000627:therapeutic use; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D012989:Soil Pollutants / Q000627:therapeutic use*; D014466:Ultraviolet Rays
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls; D000432:Methanol