title: Relationship between plasma insulin and left ventricular mass in normotensive participants of the Gubbio Study.
abstract: BACKGROUND
  There is substantial but not conclusive evidence that insulin resistance is related to left ventricular mass (LVM) in hypertensive individuals. To what extent this association is mediated by the relationship between plasma insulin and body size and build is still debated, and is poorly explored in nonhypertensive people.
  
  
  OBJECTIVE
  To explore the relationship between insulin or insulin resistance and LVM in a population-based sample of nonhypertensive participants of the Gubbio Study.
  
  
  METHODS
  Echocardiographic LVM was determined in 91 nondiabetic, nonhypertensive individuals aged 45-54 years, participating in a population-based screening. LVM normalized for height2.7 was used in the analyses; LV hypertrophy was defined as a value of > or = 50 g/m2.7 in men or > or = 47 g/m2.7 in women. Fasting plasma insulin and glucose were measured and the Homeostasis Model Assessment (HOMA) index was used as a measure of insulin resistance.
  
  
  RESULTS
  LVM was positively and significantly correlated with body mass index (BMI) (P < 0.01), waist circumference (P < 0.01) and HOMA index (P < 0.05), whereas correlations with plasma glucose and triglycerides did not reach statistical significance (P = 0.07 for both); all correlations were offset after adjusting for BMI. Fasting plasma insulin and HOMA index were not significantly different in subjects with or without LV hypertrophy (70.8 +/- 27.8 vs. 77.7 +/- 29.6 pmol/l and 2.2 +/- 1.0 vs. 2.6 +/- 1.4, respectively). Bivariate analysis performed stratifying participants above or below the 75th percentile of the sex-specific distribution for BMI (29.1 and 29.4 kg/m2 for males and females, respectively) and plasma insulin (84 pmol/l for either gender), did not result in appreciable differences in LVM due to insulin levels. Similar results were obtained replacing the HOMA index for insulin in the analysis.
  
  
  CONCLUSIONS
  In nonhypertensive individuals left ventricular mass is not associated with plasma insulin independently of body mass index.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy. ovaccaro@unina.it
authors.forename: Olga
authors.initials: O
authors.lastname: Vaccaro
authors.forename: Ondina
authors.initials: O
authors.lastname: Cardoni
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cuomo
authors.forename: Walter
authors.initials: W
authors.lastname: Panarelli
authors.forename: Martino
authors.initials: M
authors.lastname: Laurenzi
authors.forename: Mario
authors.initials: M
authors.lastname: Mancini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Riccardi
authors.forename: Alberto
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000000981:diagnostic imaging*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides