Existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries.
Establishing the existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries was the goal of the present study. Functional vascular reactivity of selective alpha(1)- and alpha(2)-adrenoceptor agonists and antagonists was studied, using a cannula inserting technique. Intraluminal administration of norepinephrine (NE), phenylephrine (PE) or BHT-933 caused a vasoconstrictive response in a dose-related manner. The relative potencies of the 3 agonists were almost the same in both arteries. NE-induced vasoconstrictions were significantly antagonized by either prazosin or rauwolscine. PE-induced responses were strongly inhibited by prazosin. BHT-933-induced constrictions were inhibited by rauwolscine. These results indicate that both alpha(1)- and alpha(2)-adrenoceptors exist in the human gastroepiploic and omental arteries.
Fukui
Daisuke
D
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Chiba
Shigetoshi
S
D058646:Adrenergic alpha-1 Receptor Agonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000368:Aged; D001158:Arteries / Q000737:chemistry* / Q000187:drug effects; D001381:Azepines / Q000008:administration & dosage / Q000494:pharmacology; D002404:Catheterization; D004305:Dose-Response Relationship, Drug; D005260:Female; D024405:Gastroepiploic Artery / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D010537:Peritoneum / Q000098:blood supply*; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D018340:Receptors, Adrenergic, alpha-1 / Q000032:analysis; D018341:Receptors, Adrenergic, alpha-2 / Q000032:analysis; D014661:Vasoconstriction / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D058646:Adrenergic alpha-1 Receptor Agonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D001381:Azepines; D011942:Receptors, Adrenergic, alpha; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D010656:Phenylephrine; D015016:Yohimbine; C015603:azepexole; D009638:Norepinephrine; D011224:Prazosin