[A case of Japanese summer-type hypersensitivity pneumonitis: monitoring with serum KL-6 and examination of the phenotype of HLA].
A 55-year-old woman was admitted with a cough and fever in August. A diagnosis of Japanese summer-type hypersensitivity pneumonitis was made on the basis of radiological, serological and pathological findings, in addition to positive returning home provocation. Serum KL-6 was monitored during the clinical course. Although KL-6 fluctuated slowly in comparison with the clinical symptoms and HRCT findings, it was considered useful for confirming the effects of treatment. Serum anti-Trichosporon antibody and the phenotype of HLA were studied in both the patient and her asymptomatic roommate, with whom she had no blood relationship. Though both were sensitized immunologically, HLA-DQ 3, which was reported to be associated with Japanese summer-type hypersensitivity pneumonitis, was detected in the patient but not in her roommate. It was suggested that HLA plays a role in the development of this disease.
Yoshioka
Hiroshige
H
Department of Respiratory Medicine, Nishi-Kobe Medical Center, 5-1-3 Kohjidai, Nishi-ku, Kobe, Japan.
Tomioka
Hiromi
H
Ohnishi
Hisashi
H
Fujiyama
Riyo
R
Sakurai
Toshiyasu
T
Tada
Kimihide
K
Sakamoto
Hiroko
H
Iwasaki
Hironobu
H
Hashimoto
Kimio
K
Imanaka
Kazufumi
K
D000542:Alveolitis, Extrinsic Allergic / Q000276:immunology*; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D012621:Seasons
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; D006680:HLA Antigens; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins