Colposcopy, cervical cytology and human papillomavirus detection as screening tools for cervical cancer.
A cohort of 77 women referred for routine screening or investigation of Pap test abnormality underwent colposcopic examination. Pap-stained liquid-based preparations were diagnosed and categorized according to the Bethesda system. Residual material on the sampling device was used to detect high-risk oncogenic human papillomavirus DNA. Although the colposcopic failure rate was higher than that of cytology, no lesion was missed when both methods were used together. High-risk types were recorded in 24% of patients with atypical squamous cells of undetermined significance, 45% with low-grade squamous intraepithelial lesions and 79% with high-grade squamous intraepithelial lesions--indicating that the efficacy of cytological screening can be improved by papillomavirus detection.
Al-Alwan
N A
NA
Department of Pathology, College of Medicine, University of Baghdad, Baghdad, Iraq.
D000328:Adult; D000368:Aged; D003127:Colposcopy / Q000592:standards*; D003218:Condylomata Acuminata / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity; D002577:Uterine Cervical Diseases / Q000150:complications* / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology*; D014626:Vaginal Smears / Q000592:standards*; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000175:diagnosis*