Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors.
A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5, 6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.
Toma
Lucio
L
Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100 Pavia, Italy. toma@chifis.unipv.it
Giovannoni
Maria Paola
MP
Vergelli
Claudia
C
Dal Piaz
Vittorio
V
Kwon
Byoung-Mog
BM
Kim
Young-Kook
YK
Gelain
Arianna
A
Barlocco
Daniela
D
D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D000097587:Sterol O-Acyltransferase 2
D004791:Enzyme Inhibitors; D011724:Pyridazines; D002785:Sterol O-Acyltransferase; D000097587:Sterol O-Acyltransferase 2