title: CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.
abstract: OBJECTIVE
  To investigate the possibility of genetic contribution of CYP1A1, CYP19, GSTM1, and GSTT1 polymorphisms to endometriosis.
  
  
  METHODS
  Genetic polymorphism analysis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  A group of 275 women with sporadic endometriosis was compared with a group of 346 fertile, endometriosis-free women.
  
  
  METHODS
  Surgical, laparoscopic, and histological examination.
  
  
  METHODS
  Blood specimens were obtained from endometriosis cases and controls. Polymerase chain reaction-based assays were performed for the determination of individual's genotype.
  
  
  RESULTS
  The CYP19 VNTR, located in intron 4 (TTTA)(10) allele increases the risk for endometriosis development (odds ratio [OR], 4.99; 95% confidence interval [95% CI], 1.351 to 18.436). The combined genotype CYP1A1 wt/m1 or m1/m1 and GSTM1 null deletion adds to this risk (OR, 1.95; 95% CI, 1.266 to 2.995 and OR, 2.23; 95% CI, 0.631 to 7.906, respectively). In contrast, the CYP1A1 wt/wt genotype exhibits a protective effect, with a 38% reduction in the odds for endometriosis development (OR, 0.62; 95% CI, 0.440 to 0.883).
  
  
  CONCLUSIONS
  Our data suggest that CYP19 VNTR (TTTA)(10) allele as well as the combined genotype CYP1A1 m1 polymorphism and GSTM1 null deletion associate with the endometriosis phenotype, whereas the GSTT1 null deletion does not.
authors.affiliation: Department of Virology, Medical School, University of Crete, Heraklion, Crete, Greece.
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Arvanitis
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Koumantakis
authors.forename: Anastasia G
authors.initials: AG
authors.lastname: Goumenou
authors.forename: Ioannis M
authors.initials: IM
authors.lastname: Matalliotakis
authors.forename: Eugenios E
authors.initials: EE
authors.lastname: Koumantakis
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Spandidos
mesh_terms: D000328:Adult; D001141:Aromatase / Q000737:chemistry / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000737:chemistry / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D004715:Endometriosis / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000737:chemistry / Q000235:genetics*; D006115:Greece; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D001141:Aromatase; D019363:Cytochrome P-450 CYP1A1; D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1