Related factors of meeting National Cholesterol Education Program-recommended goals with atorvastatin.
The aim of this study was to observe the efficacy of atorvastatin and the related factors of meeting the National Cholesterol Education Program (NCEP)-recommended low-density lipoprotein (LDL) cholesterol levels in patients with hypercholesterolemia. A total of 107 patients were treated with atorvastatin 10 mg/day for 12 weeks. Eighty % of the patients achieved the target goals. There was a significant difference in the initial body mass index (BMI) between patients achieving the target goals and those not achieving the target goals (p < 0.05). In multiple stepwise logistic regression analysis, initial BMI and complications correlated with reaching the NCEP-recommended target goals (p < 0.05). A great number of patients treated with atorvastatin, including those previously poorly controlled with other therapies, reached the target goals at the starting dose 10 mg/day. BMI may be a useful index of achieving the NCEP-recommended target goals with atorvastatin.
Yoshitomi
Yuji
Y
Miyauchi Makoto Memorial Clinic, Shizuoka, Japan. ytommy@sage.ocn.jp
Tsujibayashi
Takashi
T
Ishii
Toshikazu
T
Sakurai
Shun-ichiro
S
Nagakura
Chieko
C
Miyauchi
Atsuyoshi
A
D000368:Aged; D000069059:Atorvastatin; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D011758:Pyrroles / Q000627:therapeutic use*; D012307:Risk Factors; D012449:Safety
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D002784:Cholesterol; D000069059:Atorvastatin