title: [Cerebral angiitis and Goodpasture's syndrome].
abstract: Goodpasture's syndrome is a form of rapidly progressive glomerulonephritis with pulmonary hemorrhage in the presence of antiglomerular basement membrane antibodies. Concomittant central nervous system manifestations are exceptionally reported. We report such a case of an 55-year-old woman who developed fluctuant neurobehavioral manifestations over a 9 months period. Angiography showed cerebral arterial distal lesions compatible with the diagnosis of angiitis. The antiglomerular basement membrane antibody titer was elevated. Search for anti-neutrophil cytoplasmic antibody was negative. After the reintroduction of cyclophosphamide agent, clinical evolution was favourable. Clinical cerebral manifestations in our case are probably du to a angiitis. Few cases are reported in the literature. The role of antiglomerular basement membrane antibody in the development of the cerebral angiitis is possible.
authors.affiliation: Service de Neurologie, Fédération Neuro-Vasculaire, CHU, Saint-Etienne. pierre.garnier@univ-st-etienne.fr
authors.forename: P
authors.initials: P
authors.lastname: Garnier
authors.forename: C
authors.initials: C
authors.lastname: Deprele
authors.forename: B
authors.initials: B
authors.lastname: Pilonchéry
authors.forename: D
authors.initials: D
authors.lastname: Michel
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001037:Aphasia / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D001323:Autoantibodies; D003520:Cyclophosphamide