[Combined administration of mexidol and anti-arrhythmia agents].
The influence of mexidol on the acute toxicity and electrophysiological effects of nibentan, propranolol, and verapamil was experimentally studied. It was found that mexidol potentiates the ability of propranolol and verapamil to inhibit automatism of the sinus node and suppresses the ability of all the three drugs to increase the refractory period of myocardium. It is suggested that these effects are related to the action of mexidol upon ion channels.
Kotliarov
A A
AA
Department of Clinical Therapy, Mordvinian State University, ul. Ul'yanova 26, Saransk, Mordvinia, 430003 Russia.
Smirnov
L D
LD
Smirnova
L E
LE
Kurkina
N V
NV
Balykova
L A
LA
Kariakina
T N
TN
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D002415:Cats; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010847:Picolines / Q000494:pharmacology*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate