Noninvasive identification of myocardial sympathetic and metabolic abnormalities in a patient with restrictive cardiomyopathy--in comparison with perfusion imaging.
A 42-year-old man had the insidious onset of heart failure, and was diagnosed as having restrictive cardiomyopathy. Doppler echocardiography study showed short deceleration time of the E wave and short isovolumic relaxation time on transmitral Doppler flow. He underwent Tl-201, I-123 beta-methyl-iodophenyl pentadecanoic acid (BMIPP) and I-123-metaiodobenzylguanidine (MIBG) cardiac scintigraphy. Tl-201 studies showed normal uptake in the left ventricle indicating normal blood perfusion. I-123 BMIPP and I-123 MIBG showed reduced uptake in the inferior segment of the myocardium, indicating impairment of fatty acid metabolism and sympathetic abnormalities.
Matsuo
Shinro
S
Division of Cardiology, Shiga University of Medical Science, Otsu, Japan. smatsuo@belle.shiga-med.ac.jp
Nakae
Ichiro
I
Takada
Masahiko
M
Murata
Kiyoshi
K
Nakamura
Yasuyuki
Y
D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D000328:Adult; D002313:Cardiomyopathy, Restrictive / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D004417:Dyspnea / Q000209:etiology; D005227:Fatty Acids / Q000493:pharmacokinetics; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000294:innervation; D006801:Humans; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*
D005227:Fatty Acids; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D019797:3-Iodobenzylguanidine