Highly enantioselective 1,4-addition of diorganozinc reagents to cyclic enones using chiral diphosphite ligands derived from H8-binaphthol.
[formula: see text] High enantioselectivities have been achieved in the 1,4-addition of dialkylzincs to 2-cyclopentenone, 2-cyclohexenone, and 2-cycloheptenone with ee values up to 99% by using chiral aryl diphosphite ligands derived from H8-binaphthol.
Liang
Liang
L
Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
Au-Yeung
Terry T L
TT
Chan
Albert S C
AS