title: [Juvenile hyaline fibromatosis: 2 twin brothers affected].
abstract: BACKGROUND
  Juvenile hyaline fibromatosis is a rare hereditary genetic disease characterized by a cutaneous tumoral fibroblastic proliferation with joint involvement.
  
  
  METHODS
  We report the case of 2 homozygous twin brothers both presenting a diffuse and invalidating form of juvenile hyaline fibromatosis. The 2 boys' born of a twin pregnancy' presented at the age of 2 months a clinical picture made up by the classic association: infiltrated papulo-nodules, gingival hyperplasia and joint contracture. The diagnosis of juvenile hyaline fibromatosis suggested clinically was confirmed by the histological study of the skin.
  
  
  CONCLUSIONS
  These observations of juvenile hyaline fibromatosis's are particular in the involvement of 2 twin brothers, which to our knowledge has never been reported, the resemblance of the clinical features, and the severity of the functional handicap.
authors.affiliation: Service de Dermatologie-Vénéréologie, CHU Ibn Rochd, Casablanca, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Habibeddine
authors.forename: K
authors.initials: K
authors.lastname: Khadir
authors.forename: S
authors.initials: S
authors.lastname: Azzouzi
authors.forename: S
authors.initials: S
authors.lastname: Skalli
authors.forename: H
authors.initials: H
authors.lastname: Lakhdar
mesh_terms: D004200:Diseases in Twins / Q000175:diagnosis*; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D006818:Hyalin; D007223:Infant; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*