title: Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.
abstract: Postoperative creatinine increase is associated with adverse outcome after cardiac surgery. Although postoperative stroke and renal dysfunction are associated after cardiac surgery, suggesting a common systemic insult, a similar assessment of atrial fibrillation and renal dysfunction has not been performed. Therefore, we tested the hypothesis that patients with new-onset atrial fibrillation complicating coronary bypass surgery have a greater postoperative creatinine increase. Data were obtained for 453 elective coronary bypass surgery patients with no history of atrial fibrillation. Multivariate regression analyses of factors associated with peak fractional change in creatinine demonstrated a two-way interaction between age and atrial fibrillation (variable estimate, -1.1; P = 0.002). Similar results were obtained in a secondary multivariate model analyzing factors associated with peak postoperative creatinine (variable estimate, -0.01; P = 0.04). We confirmed our hypothesis that patients with new-onset atrial fibrillation are more likely to have acute renal dysfunction after cardiac surgery. The association of atrial fibrillation and creatinine increase diminishes with advancing age. These data are consistent with a common pathophysiology that contributes in an age-dependent fashion to the etiology of both acute renal dysfunction and atrial fibrillation after coronary bypass surgery.
  
  
  CONCLUSIONS
  We found an independent association between new-onset atrial fibrillation and postoperative creatinine increase that is influenced by age. The degree to which atrial fibrillation is associated with postoperative creatinine increase diminishes with advancing age. This interaction suggests that a common etiology for these two complications may be more important in younger patients.
authors.affiliation: Departments of *Anesthesiology and †Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Maher J
authors.initials: MJ
authors.lastname: Albahrani
authors.forename: Madhav
authors.initials: M
authors.lastname: Swaminathan
authors.forename: Barbara
authors.initials: B
authors.lastname: Phillips-Bute
authors.forename: Peter K
authors.initials: PK
authors.lastname: Smith
authors.forename: Mark F
authors.initials: MF
authors.lastname: Newman
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Mathew
authors.forename: Mark
authors.initials: M
authors.lastname: Stafford-Smith
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000453:epidemiology*; D000367:Age Factors; D001281:Atrial Fibrillation / Q000150:complications* / Q000453:epidemiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003404:Creatinine