Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.
In a further study on the chemical constituents of Garcinia assigu, two new benzophenones corresponding to the 13-O-methyl ethers (1 and 2) of the known isogarcinol and garcinol, respectively, were isolated and characterized, along with known benzophenones (3-6). Inhibitory effects of the benzophenones isolated from this plant on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and their radical-scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were demonstrated. The cyclized polyprenylbenzophenones (1-5) showed comparable or stronger potential cancer chemopreventive activity when compared to glycyrrhetic acid, a known anti-tumor promoter.
Ito
Chihiro
C
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan. itoigawa@tokaigakuen-u.ac.jp
Itoigawa
Masataka
M
Miyamoto
Yoshiaki
Y
Onoda
Saori
S
Rao
K Sundar
KS
Mukainaka
Teruo
T
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Furukawa
Hiroshi
H
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000956:Antigens, Viral / Q000378:metabolism; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D003500:Cyclization; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D006034:Glycyrrhetinic Acid / Q000494:pharmacology; D006801:Humans; D016393:Lymphoma, B-Cell; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D010851:Picrates; D010946:Plants, Medicinal / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate; D014407:Tumor Cells, Cultured / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D001577:Benzophenones; D001713:Biphenyl Compounds; C033305:Epstein-Barr virus early antigen; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D013755:Tetradecanoylphorbol Acetate; D006034:Glycyrrhetinic Acid