title: Mycaperoxide H, a new cytotoxic norsesterterpene peroxide from a Thai marine sponge Mycale sp.
abstract: Mycaperoxide H, a new cyclic norsesterterpene peroxide, was isolated from a Thai marine sponge Mycalesp. The structure of mycaperoxide H was deduced by spectroscopic and chemical analysis. Mycaperoxide H was cytotoxic against HeLa cells with an IC(50) value of 0.8 microgram/mL.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Preecha
authors.initials: P
authors.lastname: Phuwapraisirisan
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
authors.forename: Nilnaj
authors.initials: N
authors.lastname: Chaitanawisuti
authors.forename: Sirusa
authors.initials: S
authors.lastname: Kritsanapuntu
authors.forename: Piamsak
authors.initials: P
authors.lastname: Menasveta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010545:Peroxides; D013729:Terpenes; C475246:mycaperoxide H