[Effect of 17beta-estradiol on haloperidol effects in Wistar rats].
It is established that the haloperidol catalepsy is much less pronounced in Wistar females than in males. Estradiol (10 mg/kg, i.p.) decreased intensity of the haloperidol catalepsy, reduced the haloperidol-induced increase in the dopamine turnover, and decreased the level of dopamine metabolites in nucleus accumbens of both female and male test animals. However, these effects are also more pronounced in females.
Andreeva
Iu A
IuA
Neurochemical Pharmacology Laboratory, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Kudrin
V S
VS
Raevskiĭ
K S
KS
D000818:Animals; D001921:Brain / Q000378:metabolism; D002375:Catalepsy / Q000139:chemically induced* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors
D004958:Estradiol; D006220:Haloperidol; D004298:Dopamine