[The effect of AG490 on NK activity and lymphocyte transformation of PBMC].
OBJECTIVE
To examine the effect of AG490 on NK activity and lymphocyte transformation.


METHODS
Using MTT colorimetry to detect cell survival, NK activity and cell proliferation.


RESULTS
AG490 inhibited IL-2 and PHA induced peripheral blood mononuclear cell proliferation, and it inhibited NK activation.


CONCLUSIONS
As an inhibitor of JAK, AG490 can influence the function of normal cells.
Wang
R
R
Department of Immunology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
Zhang
P
P
Wei
D
D
Zhao
Z
Z
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D020014:K562 Cells / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D020032:Tyrphostins / Q000494:pharmacology*
D007376:Interleukin-2; D020032:Tyrphostins; C095512:alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; D011505:Protein-Tyrosine Kinases