[Study on the anti-carcinogenic effects of three compounds in Kaempferia galanga L].
In order to study the anti-carcinogeneic effect of three compounds isolated from Kaempferia galanga L, EBV assay, ear edema test, ornithine decarboxylase (ODC) activity and two-stage-carcinogenisis test are applied. The results show that both -cis and -trans ethyl-p-methoxycinnamate has inhibitory effect in vitro, and also has inhibitory effects in TPA tests or croton oil-induced ear edema, ODC activity in specimen of mouse epidermis and extent of papilloma, indicating a relatively strong anti-carcinogenic potential of ethyl-p-methoxycinnamate in Kaempferia galanga L.
Xue
Ying
Y
Beijing Center for Disease Control and Prevention, Beijing 100013, China.
Chen
Hang
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010212:Papilloma / Q000517:prevention & control; D012878:Skin Neoplasms / Q000517:prevention & control; D030521:Zingiberaceae / Q000737:chemistry*
D000970:Antineoplastic Agents; D002934:Cinnamates; C118580:octylmethoxycinnamate; D009955:Ornithine Decarboxylase