A discrete self-assembled metal array in artificial DNA.
DNA has a structural basis to array functionalized building blocks. Here we report the synthesis of a series of artificial oligonucleotides, d(5'-GH(n)C-3') (n = 1 to 5), with hydroxypyridone nucleobases (H) as flat bidentate ligands. Right-handed double helices of the oligonucleotides, nCu2+.d(5'-GH(n)C-3')2 (n = 1 to 5), were quantitatively formed through copper ion (Cu2+)-mediated alternative base pairing (H-Cu2+-H), where the Cu2+ ions incorporated into each complex were aligned along the helix axes inside the duplexes with the Cu2+-Cu2+ distance of 3.7 +/- 0.1 angstroms. The Cu2+ ions were coupled ferromagnetically with one another through unpaired d electrons to form magnetic chains.
Tanaka
Kentaro
K
Department of Chemistry, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Tengeiji
Atsushi
A
Kato
Tatsuhisa
T
Toyama
Namiki
N
Shionoya
Mitsuhiko
M
D020029:Base Pairing; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D008024:Ligands; D008280:Magnetics; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D008024:Ligands; D009838:Oligodeoxyribonucleotides; D011728:Pyridones; D003300:Copper; D004247:DNA