title: [The association between IL-1 gene polymorphisms and susceptibility to severe periodontitis].
abstract: OBJECTIVE
  The purpose of this study was to investigate the relationship between IL-1 gene polymorphisms and susceptibility to severe periodonitis in Chinese of the Han Nationality.
  
  
  METHODS
  DNA samples with buccal swabs were collected from 30 patients with severe adult periodontitis (AP), 20 patients with rapid progressive periodontitis (RPP) and 94 healthy control (HC) individuals. Polymorphisms in the IL-1 gene cluster were analyzed with PCR-RFLP.
  
  
  RESULTS
  It was found that the frequency of IL-1B + 3953/Taq I allele 2 was significantly higher in severe AP patients (OR = 6.8, P < 0.05) and RPP patients (OR = 9.6, P < 0.05) than in healthy controls, and the frequency of IL-1RN intron II/VNTR allele 2 was significantly higher in the group of severe AP patients (OR = 6.3, P < 0.05) than in the group of healthy controls.
  
  
  CONCLUSIONS
  IL-1B + 3953/Taq I allele 2 and IL-1RN nitrol IL/VNTR allele 2 are genetic indicators of susceptibility to severe AP and RPP, and both AP and RPP are genetic heterogeneous.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Duan
authors.forename: Jincai
authors.initials: J
authors.lastname: Zhang
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007375:Interleukin-1