title: Effects of voluntary resistance exercise on heme biosynthesis in rats given glucocorticoid-injections.
abstract: To identify the effects of a tower-climbing exercise on bone marrow heme biosynthesis and hematological status in rats given glucocorticoid-injections as a model of aging, 29 male Sprague-Dawley rats, 10 weeks of age, were assigned to three groups: a saline control (C, n = 9), a glucocorticoid-sedentary (GS, n = 10) group, and a glucocorticoid-exercise (GE, n = 10) group. The GS and GE groups were given 2 mg/kg prednisolone daily, and the C group was given 2 ml of saline daily, subcutaneously. Each group was meal-fed commercial rat chow isoenergetically and given free access to water for 8 weeks. The GE group were allowed to climb a 200-cm tower to drink water from a bottle set at the top of it. Weight gain during the 8-week experimental period was greater in the C group than in the GS and GE groups. The gastrocnemius and tibialis anterior muscles were heavier in the C group than in other groups. The hematological parameters were not influenced by glucocorticoid administration with or without climbing exercise. Bone marrow delta-aminolevulinic acid dehydratase activity was significantly higher in the GE group than in the C group. These results suggest that 8 weeks of climbing exercise increases heme biosynthesis without alteration of hematological status in rats given glucocorticoid-injections. Resistance exercise may be a preventive therapy for iron-deficiency anemia associated with aging.
authors.affiliation: Graduate School of East-West Medical Science, Kyung-Hee University, Seoul, Korea.
authors.forename: Hyung-Sook
authors.initials: HS
authors.lastname: Kang
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Matsuo
authors.forename: Ryo-Won
authors.initials: RW
authors.lastname: Choue
authors.forename: Masashige
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000375:Aging; D000818:Animals; D001835:Body Weight; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D005938:Glucocorticoids / Q000494:pharmacology; D006418:Heme / Q000096:biosynthesis*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D005938:Glucocorticoids; D017392:Thiobarbituric Acid Reactive Substances; D006418:Heme; D011239:Prednisolone; D000623:Porphobilinogen Synthase