[Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer].
OBJECTIVE
Some research showed that carcinoembryonic antigen(CEA) related to cell adhesion and cyclooxygenesis 2(COX2) may be related to colorectal carcinogenesis. This study was designed to investigate the expression of CEA and COX2 to evaluate their effects on the tumorigenesis and progression in the colorectal cancer.


METHODS
The immunohistochemistry was used to determine the expression of CEA and COX2 in the 34 tissues of colorectal cancer,border of cancer, normal mucosa,and 19 metastatic lymph nodes.


RESULTS
CEA expression level had a correlation with the differentiation of the tumor tissue (P< 0.05), but had no correlation with lymph node metastasis,Dukes' stage,the patients' age,sex,and the location of tumor (P >0.05). The level of COX2 increased in the majority of tumor tissues (31/34) and all of the lymph node metastases, but had no correlation with the tumor differentiation, stage,location,patients' age and sex(P >0.05). There was significant difference of expression of CEA and COX2 between tumor and nontumor tissues (P< 0.01).


CONCLUSIONS
The abnormal expression of CEA and COX2 plays a role in the carcinogenesis and development of colorectal cancer.
Chen
Zhi-Kang
ZK
Department of General Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, PR China. chen_zk74@hotmail.com
Ouyang
Zhi-Ting
ZT
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases