title: Combined small cell carcinoma and clear cell carcinoma of the gallbladder: report of a case and review of the literature.
abstract: We report a case of an incidental combined carcinoma of the gallbladder in a 66-year-old woman who underwent cholecistectomy for gallstones. The neoplasm was mainly constituted by a clear cell component and a small cell, chromogranin-positive one; it also showed some areas of conventional adenocarcinoma and foci of vascular invasion. The patient died after 3 years following treatment with combination chemotherapy. The histologic and immunohistochemical profile of the lesion is described, together with a brief review of the pertinent bibliography.
authors.affiliation: Servizio di Anatomia ed Istologia Patologica, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. piana.simanetta@asmn.re.it
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piana
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Stefania
authors.initials: S
authors.lastname: Corrado
authors.forename: Innocenza
authors.initials: I
authors.lastname: Putrino
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gardini
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000150:complications / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D018198:Mixed Tumor, Malignant / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery