Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin.
The synthesis and characterization of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin is reported. The phototoxicity on C6 cell lines and the pharmacokinetics are also reported as preliminary results showing a very high tumor to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.
Ferrand
Yann
Y
Laboratoire de Chimie Organométallique et Biologique, UMR CNRS 6509, Université de Rennes 1, 35042 Rennes cedex, France.
Bourré
Ludovic
L
Simonneaux
Gérard
G
Thibaut
Sonia
S
Odobel
Fabrice
F
Lajat
Y
Y
Patrice
Thierry
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008652:Mesoporphyrins / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D012015:Reference Standards; D012878:Skin Neoplasms / Q000188:drug therapy; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; D011166:Porphyrins; C072269:temoporfin