title: Mice, microbes and models of infection.
abstract: We urgently need animal models to study infectious disease. Mice are susceptible to a similar range of microbial infections as humans. Marked differences between inbred strains of mice in their response to pathogen infection can be exploited to analyse the genetic basis of infections. In addition, the genetic tools that are available in the laboratory mouse, and new techniques to monitor the expression of bacterial genes in vivo, make it the principal experimental animal model for studying mechanisms of infection and immunity.
authors.affiliation: German Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany
authors.forename: Jan
authors.initials: J
authors.lastname: Buer
authors.forename: Rudi
authors.initials: R
authors.lastname: Balling
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000235:genetics / Q000276:immunology; D027682:Cation Transport Proteins / Q000235:genetics; D003141:Communicable Diseases / Q000209:etiology* / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000172:deficiency / Q000235:genetics; D004195:Disease Models, Animal; D029721:Drosophila Proteins; D005798:Genes, Bacterial; D005820:Genetic Testing; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D051616:Neuronal Apoptosis-Inhibitory Protein; D020411:Oligonucleotide Array Sequence Analysis; D011956:Receptors, Cell Surface / Q000235:genetics; D051193:Toll-Like Receptors; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D027682:Cation Transport Proteins; D016207:Cytokines; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D000099173:Natural Resistance-associated Macrophage Protein 1; C496801:Naip1 protein, mouse