title: Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease.
abstract: The paraoxonase (PON1) Gln192-->Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1*R allele frequency significantly lower than the control group (0.225 vs. 0.281, P=0.049). In the CAD patients the *R allele was more frequent than in the controls (0.230 vs. 0.213), though not significantly (P=0.28). The odds ratios (OR) adjusted for age, gender, and APOE polymorphism by logistic regression analysis highlighted that in AD the PON1 RR genotype was significantly protective (OR=0.41, 95% CI=0.19-0.90; P=0.025), whereas in CAD it appeared to be a significant risk factor (OR=5.11, 95% CI=1.09-23.9; P=0.038) limited to younger patients.
authors.affiliation: CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, P.le Aldo Moro 5, 00185, Rome, Italy. renato.scacchi@uniroma1.it
authors.forename: Renato
authors.initials: R
authors.lastname: Scacchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gambina
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Martini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Broggio
authors.forename: Teresio
authors.initials: T
authors.lastname: Vilardo
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Corbo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D043303:Aryldialkylphosphatase; D003324:Coronary Artery Disease / Q000235:genetics*; D004950:Esterases / Q000097:blood / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human