Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells.
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (K(i)>10(6)), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells.
Augustus
Todd M
TM
Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
Anderson
Joel
J
Hess
Suzanne M
SM
Bierbach
Ulrich
U
D000166:Acridines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000166:Acridines; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D009944:Organoplatinum Compounds; D004247:DNA; C427203:calf thymus DNA; D013890:Thiourea