Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis.
In order to analyze the incidence of thrombophilia in southern Taiwan, we studied the prevalence of antithrombin (AT), protein C (PC), and protein S (PS) deficiencies, the prevalence of factor V Leiden mutation, and the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) in 56 patients < or =65 years old with deep venous thrombosis (DVT). Of 56 patients, 30 were male, 26 female, and the mean age of the patients was 43 years (18-65 years). None had factor V mutation or activated PC resistance; 21 patients (37.5%) showed abnormal results: 4 (7.1%) had AT deficiencies, 6 (10.7%) PC deficiencies, 6 (10.7%) PS deficiencies, 2 (3.6%) a combined PC and PS deficiency, and 3 (5.4%) LA and ACA. Only PC and PS deficiencies were significantly associated with increased risk for the development of thrombosis with an odds ratio of 4.2 (95% confidence interval: 1.2-15.0, P=0.018) and 8.1 (95% confidence interval: 1.6-40.6, P=0.003), respectively. We concluded that the prevalence of heritable thrombophilia (34.0%) in Taiwan is higher than that in Western countries, but that it is lower than previously reported in Hong Kong and Taiwan. We attribute this to selection bias.
Chen
T-Y
TY
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng-Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan. teresa@mail.ncku.edu.tw.
Su
W-C
WC
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng-Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan.
Tsao
C-J
CJ
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng-Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan.
D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D020152:Antithrombin III Deficiency / Q000453:epidemiology; D015982:Bias; D016022:Case-Control Studies; D005165:Factor V; D005260:Female; D006801:Humans; D015994:Incidence; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D020151:Protein C Deficiency / Q000453:epidemiology; D018455:Protein S Deficiency / Q000453:epidemiology; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000097:blood* / Q000453:epidemiology
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; C095381:factor V Leiden; D005165:Factor V