Sticky business: orchestrating cellular signals at adherens junctions.
Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.
Perez-Moreno
Mirna
M
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
Jamora
Colin
C
Fuchs
Elaine
E
D000199:Actins / Q000378:metabolism; D022005:Adherens Junctions; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002455:Cell Division; D003599:Cytoskeleton / Q000378:metabolism; D015536:Down-Regulation; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D009154:Mutation; D010766:Phosphorylation; D015398:Signal Transduction; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D000199:Actins; D015820:Cadherins; D005656:Fungal Proteins; D020558:GTP Phosphohydrolases; D020742:rhoA GTP-Binding Protein