Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes.
OBJECTIVE
To investigate whether quantity or quality of dietary fat predicts coronary heart disease (CHD) events in middle-aged type 2 diabetic subjects.


METHODS
The dietary habits of 366 type 2 diabetic men and 295 women, aged 45-64 years and free from CHD, were assessed with a 53-item food frequency questionnaire. They were followed up for 7 years.


RESULTS
Men in the highest tertile of the polyunsaturated/saturated fat (P/S) ratio (>0.28) had a significantly lower risk for CHD death than men in the two lowest tertiles (5.0 vs. 14.2%, P = 0.009). The risk for all CHD events was 14.2 vs. 23.2%, respectively (P = 0.044). P/S ratio did not predict CHD events in women. In Cox multiple regression analyses taking into account other cardiovascular risk factors, the highest P/S ratio tertile was associated with the lowest rate of CHD death in men (P = 0.048).


CONCLUSIONS
Low P/S ratio in men predicted future CHD events in type 2 diabetic subjects independently of conventional CHD risk factors.
Soinio
Minna
M
Department of Medicine, University of Turku, Turku, Finland. minna.soinio@tyks.fi
Laakso
Markku
M
Lehto
Seppo
S
Hakala
Paula
P
Rönnemaa
Tapani
T
D000368:Aged; D000428:Alcohol Drinking / Q000401:mortality; D000818:Animals; D001939:Bread; D003327:Coronary Disease / Q000401:mortality* / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D005399:Fishes; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
D004041:Dietary Fats