title: Quantitation of film coating on Zantac 75 mg tablets and Epivir HBV 100 mg tablets by ICP-AES.
abstract: OBJECTIVE
  To present a selective analytical Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) method developed and validated for the quantitation of tablet film coatings containing titanium.
  
  
  METHODS
  Tablet samples were decomposed by either digestion or dry ashing. The amount of film tablet coating was calculated based on titanium content of the sample.
  
  
  RESULTS
  The reported ICP-AES method was accurate, precise, sensitive and linear for determination of titanium concentrations from 2.9 to 8.6 ppm.
  
  
  CONCLUSIONS
  This method provides an accurate determination of the amount of coating on a tablet and has general applicability for a variety of coating formulations containing different elements.
authors.affiliation: Pharmaceutical Development Department, GlaxoSmithKline Inc., 7333 Mississauga Rd. North, Mississauga, ON, Canada L5N 6L4. chantal.h.incledon@gsk.com
authors.forename: Chantal
authors.initials: C
authors.lastname: Incledon
authors.forename: Chantal
authors.initials: C
authors.lastname: Paquet
authors.forename: Andrea
authors.initials: A
authors.lastname: Johnston
authors.forename: Rick
authors.initials: R
authors.lastname: Jairam
authors.forename: Lenny
authors.initials: L
authors.lastname: Dass
authors.forename: Herman
authors.initials: H
authors.lastname: Lam
mesh_terms: D019380:Anti-HIV Agents / Q000032:analysis*; D000897:Anti-Ulcer Agents / Q000032:analysis*; D007202:Indicators and Reagents; D019259:Lamivudine / Q000032:analysis*; D011899:Ranitidine / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D013052:Spectrometry, X-Ray Emission; D013608:Tablets, Enteric-Coated / Q000032:analysis*; D014025:Titanium
chemical_list: D019380:Anti-HIV Agents; D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D013608:Tablets, Enteric-Coated; C009495:titanium dioxide; D019259:Lamivudine; D011899:Ranitidine; D014025:Titanium