Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion.
OBJECTIVE
To investigate if the presence of factor V Leiden has an influence on the prognosis in central retinal vein occlusion (CRVO).


METHODS
166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event.


RESULTS
56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04).


CONCLUSIONS
The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.
Hvarfner
C
C
Department of Ophthalmology, Lund University Hospital, 211 85 Lund, Sweden. charlotte.hvarfner@oft.lu.se
Hillarp
A
A
Larsson
J
J
D020016:Activated Protein C Resistance / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D005165:Factor V / Q000032:analysis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D015861:Retinal Neovascularization / Q000235:genetics* / Q000378:metabolism; D012170:Retinal Vein Occlusion / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors
C095381:factor V Leiden; D005165:Factor V