title: [Drug sensitivity and beta-lactamase producibility of various types of bacteria clinically isolated during the period from December 1999 to February 2000].
abstract: beta-Lactamase activity and drug sensitivity were measured in 744 strains from 8 species of bacteria isolated at medical institutions in Chikugo District of Fukuoka Prefecture during the period from December 1999 to February 2000. Nitrocefin test revealed that beta-lactamase was positive in 48% of S. aureus, 7% of H. influenzae, and 92% of M. catarrhalis, and acidometry revealed that penicillinase/cephalosporinase were positive in 13%/14% of E. coli, 22%/8% of K. pneumoniae, 47%/97% of E. cloacae, 3%/65% of S. marcescens, and 10%/36% of P. aeruginosa. Based on the assessment of the MIC values of various types of antibacterial drugs for beta-lactamase-producing strains, there were 11 strains (1 strain of K. pneumonia, 6 strains of E. cloacae, and 4 strains of P. aeruginosa) of class-B beta-lactamase-producing bacteria out of a total of 496 strains of Enterobacteriaceae and Pseudomonas aeruginosa. The results of PCR analysis suggested that 1 strain of K. pneumonia, 1 strain of E. cloacae, and 4 strains of P. aeruginosa produced metallo-beta-lactamase. There was no strain (E. coli and K. pneumoniae) of ESBL-producing bacteria. BLNAR strains, on the other hand, were found in 9% (9/100) of H. influenzae.
authors.affiliation: Department of Laboratory Medicine, Kurume University Hospital.
authors.forename: Kouji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Chie
authors.initials: C
authors.lastname: Kinosita
authors.forename: Hideko
authors.initials: H
authors.lastname: Yoshinaga
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sonda
authors.forename: Takako
authors.initials: T
authors.lastname: Itoyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oyamada
authors.forename: Katsunari
authors.initials: K
authors.lastname: Kajimura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kondou
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Sagawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ouno
authors.forename: Keiko
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Souda
authors.forename: Kazumi
authors.initials: K
authors.lastname: Hara
authors.forename: Miyako
authors.initials: M
authors.lastname: Kakihara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tanaka
authors.forename: Miwako
authors.initials: M
authors.lastname: Ryutou
authors.forename: Akiko
authors.initials: A
authors.lastname: Shichiji
authors.forename: Kayoko
authors.initials: K
authors.lastname: Nakashima
authors.forename: Kazushige
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Reiko
authors.initials: R
authors.lastname: Tabira
authors.forename: Shigeko
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Tsutsumi
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology*; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006193:Haemophilus influenzae / Q000187:drug effects / Q000201:enzymology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D001936:Moraxella catarrhalis / Q000187:drug effects / Q000201:enzymology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001618:beta-Lactamases