Generation of major histocompatibility complex class I antigens.
Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules on the surface of antigen-presenting cells is an effective extracellular representation of the intracellular antigen content. The intracellular proteasome-dependent proteolytic machinery is required for generating MHC class I-presented peptides. These peptides appear to be derived mainly from newly synthesized defective ribosomal products, ensuring a rapid cytotoxic T lymphocyte-mediated immune response against infectious pathogens. Here we discuss the generation of MHC class I antigens on the basis of the currently understood molecular, biochemical and cellular mechanisms.
Yang
Young
Y
Johnson & Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA. yyang@prdus.jnj.com
D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000378:metabolism; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; D014780:Viruses / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity
D015395:Histocompatibility Antigens Class I; D009097:Multienzyme Complexes; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex