title: Erythromycin and clindamycin resistance and telithromycin susceptibility in Streptococcus agalactiae.
abstract: The rates of resistance to erythromycin and clindamycin among Streptococcus agalactiae strains isolated in our hospital increased from 4.2 and 0.8% in 1993 to 17.4 and 12.1%, respectively, in 2001. Erythromycin resistance was mainly due to the presence of an Erm(B) methylase, while the M phenotype was detected in 3.8% of the strains. Telithromycin was very active against erythromycin-resistant strains, irrespective of their mechanisms of macrolide resistance.
authors.affiliation: Department of Clinical Microbiology, Hospital Clínico San Carlos, 28040 Madrid, Spain. cbetriu@efd.net
authors.forename: C
authors.initials: C
authors.lastname: Betriu
authors.forename: E
authors.initials: E
authors.lastname: Culebras
authors.forename: M
authors.initials: M
authors.lastname: Gómez
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.forename: B A
authors.initials: BA
authors.lastname: Sánchez
authors.forename: M C
authors.initials: MC
authors.lastname: Agreda
authors.forename: J J
authors.initials: JJ
authors.lastname: Picazo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013030:Spain / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D013292:Streptococcus agalactiae / Q000187:drug effects*; D013753:Tetracycline Resistance
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin; C106791:telithromycin