Enabling parallel protein analysis through mass spectrometry.
The targets of the majority of drugs on the market and in development are proteins, and the efficient analysis of these molecules is critical to defining targets for better therapeutic intervention. Mass spectrometry is currently the key technology for parallel protein analysis (also referred to as proteomics). In this review we will describe recent advances in mass spectrometry instrumentation, methods and applications that are likely to impact drug discovery.
Domon
Bruno
B
Alving
Kim
K
He
Tao
T
Ryan
Terence E
TE
Patterson
Scott D
SD
D000818:Animals; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods* / Q000639:trends; D011506:Proteins / Q000032:analysis* / Q000235:genetics*; D040901:Proteomics / Q000379:methods / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D011506:Proteins