Prediction of Setschenow constants.
The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, K(ow), of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.
Ni
Nina
N
College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA. na@pharmacy.arizona.edu
Yalkowsky
Samuel H
SH
D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002627:Chemistry, Physical; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008956:Models, Chemical; D000442:Octanols / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D012997:Solvents; D014867:Water / Q000737:chemistry
D000442:Octanols; D009930:Organic Chemicals; D012996:Solutions; D012997:Solvents; D014867:Water; D012965:Sodium Chloride