Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride.
Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride in pyridine produced adenosine 5'-phosphoramidates in good yields under mild conditions, it is interesting that nucleophilic attack of amino acid methyl esters only occurred on alpha-phosphorus of ADP.
Fu
Hua
H
Bioorganic Phosphorus Chemistry Lab of Education Ministry, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, P. R. China. fuhua@mail.tsinghua.edu.cn
Han
Bo
B
Zhao
Yu-Fen
YF
D000244:Adenosine Diphosphate / Q000737:chemistry*; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D014297:Trimethylsilyl Compounds; C034515:phenylalanine methyl ester; D000249:Adenosine Monophosphate; D010649:Phenylalanine; C015651:adenosine 5'-phosphoramidate; D000244:Adenosine Diphosphate