[Tryptase and fatal anaphylaxic reaction].
OBJECTIVE
To investigate the relationship between tryptase in serum and anaphylaxis.


METHODS
The concentrations of tryptase in the sera of heart blood in three persons died from anaphylaxis shock were detected by ELISA. The first sample was obtained from a man, aged 38, died of injecting Amikacin. The second sample was obtained from a man, aged 42, died of injecting Cephradine. The third sample was from a woman, aged 39, died of injecting Lincomycin. All samples were stored in -20 degrees C.


RESULTS
The concentrations of tryptase in sera were 52 ng/ml, 121 ng/ml and 0.73 ng/ml. It was unknown why the concentration of tryptase in the third sample was normal.


CONCLUSIONS
In fetal anaphylaxia reaction tryptase measurement is a useful indicator, but the diagnosis is not to be based on the test alone.
Shen
Yi-wen
YW
Department of Forensic Medicine, Shanghai Medical School, Fudan University, Shanghai 200032. shenyiwen88@citiz.net
Lu
Chao
C
Zhao
Zi-qin
ZQ
D000328:Adult; D000707:Anaphylaxis / Q000201:enzymology*; D015415:Biomarkers / Q000097:blood; D002423:Cause of Death; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000201:enzymology; D011180:Postmortem Changes; D012189:Retrospective Studies; D012697:Serine Endopeptidases / Q000097:blood*; D053802:Tryptases
D015415:Biomarkers; D012697:Serine Endopeptidases; D053802:Tryptases