title: Disseminated cutaneous sporotrichosis in a patient with AIDS: report of a case.
abstract: We describe a case report of disseminated cutaneous sporotrichosis as the initial presentation of AIDS in a 24-year-old HIV-positive male patient. He presented multiple ulcerated skin lesions distributed over the face, thorax, legs and arms. Biopsy of one of the cutaneous lesions was suggestive of sporotrichosis and culture isolated Sporothrix schenckii. Itraconazole was started and the lesions progressively resolved after 15 days of medication. The patient was discharged with this medication but he did not return for follow-up. He died three months later in another hospital. Therapy of sporotrichosis in HIV-infected patients remains unclear and the response to therapy is variable. Itraconazole is highly concentrated in the skin and is one of the options for treatment of disseminated sporotrichosis.
authors.affiliation: Infectious Diseases Division, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Miriam Tomoko Mitsuno
authors.initials: MT
authors.lastname: Carvalho
authors.forename: Adriana Pinheiro
authors.initials: AP
authors.lastname: de Castro
authors.forename: Cristiane
authors.initials: C
authors.lastname: Baby
authors.forename: Betina
authors.initials: B
authors.lastname: Werner
authors.forename: José
authors.initials: J
authors.lastname: Filus Neto
authors.forename: Flávio
authors.initials: F
authors.lastname: Queiroz-Telles
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D013175:Sporothrix / Q000302:isolation & purification*; D013174:Sporotrichosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole