title: Plasmid relaxation induced by copper metalated diglycine conjugates under heterogeneous reaction conditions.
abstract: This paper reports synthesis and plasmid modification activities of a new class of insoluble copper-metalated diglycine conjugates, containing aliphatic linkers of varying length. Besides providing significant rate enhancement for model phosphate ester cleavage, these constructs also displayed efficient supercoiled plasmid scission, in the absence of co-oxidants, under heterogeneous catalytic conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016 (UP), India.
authors.forename: C
authors.initials: C
authors.lastname: Madhavaiah
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004278:DNA, Superhelical / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry; D006033:Glycylglycine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D007700:Kinetics; D009596:Nitrophenols / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009943:Organophosphorus Compounds / Q000737:chemistry; D010957:Plasmids / Q000737:chemistry*; D012995:Solubility
chemical_list: D003432:Cross-Linking Reagents; D004278:DNA, Superhelical; D016166:Free Radical Scavengers; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D006033:Glycylglycine; D003300:Copper