Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine-magnesium exchange reaction.
The successive addition of PhMgCl and i-PrMgCl to functionalised iodoanilines allows their conversion to the corresponding amino-functionalised Grignard reagents, which react smoothly with a range of electrophiles in high yield.
Varchi
Greta
G
National Research Council, Research Area of Bologna (CNR-ISOF), Via Gobetti 101, 40129 Bologna, Italy.
Kofink
Christiane
C
Lindsay
David M
DM
Ricci
Alfredo
A
Knochel
Paul
P