title: Antiplasmodial and antifungal activities of iridal, a plant triterpenoid.
abstract: Iridal, a triterpenoidic compound extracted from Iris germanica L., was previously shown to have an interesting activity on two cultured human tumor cell lines (A2780 and K562). In the present work, this same product was tested in vitro on Plasmodium falciparum chloroquine-resistant and -sensitive strains, in vivo on P. vinckei, and on some Candida albicans and C. parapsilosis strains too. The IC(50) obtained in vitro on human malaria strain ranged from 1.8 to 26.0 microg/ml and the ED(50) in vivo is about 85 mg/kg/day by intraperitoneal route. The minimal inhibitory concentrations were higher than to 50 microg/ml, whatever the strain of yeast tested. This product presents an antiplasmodial activity similar to that obtained with extracts from the plant Azadirachta indica classically taken as reference in malaria phytomedicine. Conversely iridal shows no important antifungal activity. The specific activity of iridal on human malaria parasite and on tumor cell lines is discussed.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, F-31077 Toulouse Cedex 4, France. francoise.vical@toulouse.inserm.fr
authors.forename: Françoise
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: Christine
authors.initials: C
authors.lastname: Imbert
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Bonfils
authors.forename: Yves
authors.initials: Y
authors.lastname: Sauvaire
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D031601:Azadirachta / Q000737:chemistry; D002175:Candida / Q000145:classification / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D002738:Chloroquine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal; D027621:Iridaceae / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D000962:Antimalarials; D014315:Triterpenes; C473636:iridal; D002738:Chloroquine