title: Insulin sensitivity and the diffuseness of coronary artery disease in humans.
abstract: OBJECTIVE
  To study the relationship between insulin sensitivity and diffuse coronary artery disease.
  
  
  METHODS
  Ninety-two consecutive patients underwent coronary angiography were enrolled in the study. Relationships between the results of angiograms and both glucose tolerance and blood lipids were analyzed.
  
  
  RESULTS
  The mean age of the 92 patients (70 males, 22 females) was 65.4 +/- 6.3 y. In the 78 patients diagnosed by angiography as coronary artery disease, diffuse lesion was more common in diabetic patients than in those without a diabetes history (12/13 vs 24/65, P = 0.00026). Fasting glucose [(6.06 +/- 2.43) x 10(-3) mol/L vs (4.80 +/- 1.47) x 10(-3) mol/L, P = 0.009], glucose levels at one hour [(12.37 +/- 4.38) x 10(-3) mol/L vs (9.10 +/- 3.97) x 10(-3) mol/L, P = 0.001], two hours [(11.12 +/- 5.64) x 10(-3) mol/L vs (7.49 +/- 4.29) x 10(-3) mol/L, P = 0.003] and three hours [(8.11 +/- 5.51) x 10(-3) mol/L vs (5.56 +/- 3.46) x 10(-3) mol/L, P = 0.020] after food were higher in patients with diffuse coronary disease than in those with non-diffuse coronary disease. Differences in the insulin sensitivity index (ISI) between the two groups was statistically significant (-4.36 +/- 0.52 vs -3.89 +/- 0.69, P = 0.003). The incidence of multiple-vessel disease in diabetic patients was higher than that in non-diabetic patients (12/13 vs 33/65, P = 0.00565). Glucose levels at two hours [(10.22 +/- 5.57) x 10(-3) mol/L vs (7.67 +/- 4.43) x 10(-3) mol/L, P = 0.034] and three hours [(7.90 +/- 5.47) x 10(-3) mol/L vs (5.22 +/- 2.79) x 10(-3) mol/L, P = 0.007] after food were higher in patients with multiple-vessel disease than in those with single-vessel disease. Impaired insulin sensitivity without a history of diabetes mellitus was commonly seen in patients with coronary artery disease.
  
  
  CONCLUSIONS
  The diffuseness of coronary artery disease is associated with insulin sensitivity and blood glucose levels. Insulin resistance is a common phenomenon in non-diabetic patients.
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing 100034, China. dr-hongtao@yahoo.com.cn
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
authors.forename: Guoan
authors.initials: G
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003326:Coronary Circulation; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D008055:Lipids