title: 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?
abstract: Recent studies suggest that a common theme links the diverse elements of pineal photoneuroendocrine transduction--regulation via binding to 14-3-3 proteins. The elements include photoreception, neurotransmission, signal transduction and the synthesis of melatonin from tryptophan. We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction.
authors.affiliation: Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development/NIH 49/6A82, Bethesda, MD 20892-4480, USA. klein@helix.nih.gov
authors.forename: D C
authors.initials: DC
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: Ganguly
authors.forename: S L
authors.initials: SL
authors.lastname: Coon
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: P
authors.initials: P
authors.lastname: Gaildrat
authors.forename: F
authors.initials: F
authors.lastname: Morin
authors.forename: J L
authors.initials: JL
authors.lastname: Weller
authors.forename: T
authors.initials: T
authors.lastname: Obsil
authors.forename: A
authors.initials: A
authors.lastname: Hickman
authors.forename: F
authors.initials: F
authors.lastname: Dyda
mesh_terms: D048948:14-3-3 Proteins; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000737:chemistry / Q000378:metabolism; D008027:Light; D055537:Light Signal Transduction / Q000502:physiology*; D008550:Melatonin / Q000378:metabolism; D008958:Models, Molecular; D009490:Neurosecretory Systems / Q000378:metabolism*; D009638:Norepinephrine / Q000502:physiology; D010870:Pineal Gland / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014446:Tyrosine 3-Monooxygenase / Q000737:chemistry / Q000145:classification / Q000378:metabolism / Q000502:physiology* / Q000528:radiation effects
chemical_list: D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin; D009638:Norepinephrine