title: Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of alpha-amino acids.
abstract: A nitrone was used as a synthetically useful radical acceptor in carbon-carbon bond-forming radical reactions; the intermolecular addition of alkyl radicals to chiral glyoxylic nitrone was studied; a high degree of stereocontrol in radical addition to glyoxylic nitrone was achieved to provide a new method for asymmetric synthesis of alpha-amino acids.
authors.affiliation: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyabe
authors.forename: Masako
authors.initials: M
authors.lastname: Teramachi
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
authors.forename: Takeaki
authors.initials: T
authors.lastname: Naito
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis*; D005609:Free Radicals / Q000737:chemistry; D009589:Nitrogen Oxides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D005609:Free Radicals; D009589:Nitrogen Oxides; C015388:nitrones