title: Influence of slight to moderate risk for birth hypoxia on acquisition of cognitive and language function in the preterm infant: a cross-sectional comparison with preterm-birth controls.
abstract: The cognitive and language performance of a group of 26 preterm-birth preschool and early school-age children with slight to moderate risk for perinatal hypoxia was compared with the performance of a preterm-birth comparison group of 26 children. Despite the relatively small discrepancy in degree of risk, the cognitive performance of the 2 groups diverged significantly. When data for children with known perinatal arterial pH were combined, a curvilinear (quadratic) regression model provided the best fit. Increasing acidosis was linearly related to decreases in cognitive skills, with the bend in the curve occurring well within the normal range of pH values. Hence, in the preterm infant, even minor risk for birth hypoxia may result in discernible deviation from the expected developmental trajectory.
authors.affiliation: Department of Psychology, University of Memphis, USA.
authors.forename: Tracy
authors.initials: T
authors.lastname: Hopkins-Golightly
authors.forename: Sarah
authors.initials: S
authors.lastname: Raz
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Sander
mesh_terms: D000142:Acidosis, Respiratory / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D001034:Apgar Score; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007805:Language Development Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007859:Learning Disabilities / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D012044:Regression Analysis; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000453:epidemiology; D012306:Risk; D013714:Tennessee / Q000453:epidemiology