title: Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice.
abstract: Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.
authors.affiliation: Department of Applied Chemistry, Osaka Institute of Technology, Japan. tera@chem.oit.ac.jp
authors.forename: Tadamasa
authors.initials: T
authors.lastname: Terai
authors.forename: Kanehiro
authors.initials: K
authors.lastname: Osakabe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Katai
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Isao
authors.initials: I
authors.lastname: Narama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsuura
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Katakawa
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Tetsumi
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008813:Mice, Inbred ICR; D023382:Toxicity Tests, Acute / Q000379:methods*
chemical_list: D004224:Diterpenes; C020750:grayanotoxin II