International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors.
The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic acid. Their diverse and potent actions are associated with specific receptors. Recent molecular techniques have established the nucleotide and amino acid sequences and confirmed the evidence that suggested the existence of different G-protein-coupled receptors for these lipid mediators. The nomenclature for these receptors has now been established for the leukotrienes. BLT receptors are activated by leukotriene B(4) and related hydroxyacids and this class of receptors can be subdivided into BLT(1) and BLT(2). The cysteinyl-leukotrienes (LT) activate another group called CysLT receptors, which are referred to as CysLT(1) and CysLT(2). A provisional nomenclature for the lipoxin receptor has also been proposed. LXA(4) and LXB(4) activate the ALX receptor and LXB(4) may also activate another putative receptor. However this latter receptor has not been cloned. The aim of this review is to provide the molecular evidence as well as the properties and significance of the leukotriene and lipoxin receptors, which has lead to the present nomenclature.
Brink
Charles
C
Centre National de la Recherche Scientifique UMR 7131, Hôpital Broussais, Bâtiment René Leriche, Paris, France. charlesbrink@hotmail.com
Dahlén
Sven-Erik
SE
Drazen
Jeffrey
J
Evans
Jilly F
JF
Hay
Douglas W P
DW
Nicosia
Simonetta
S
Serhan
Charles N
CN
Shimizu
Takao
T
Yokomizo
Takehiko
T
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000737:chemistry / Q000378:metabolism*; D007390:International Agencies; D008024:Ligands; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000145:classification* / Q000378:metabolism; D044042:Receptors, Formyl Peptide; D018077:Receptors, Leukotriene / Q000737:chemistry / Q000145:classification* / Q000378:metabolism; D044067:Receptors, Lipoxin; D016415:Sequence Alignment; D009626:Terminology as Topic
C105101:FPR2 protein, human; D006893:Hydroxyeicosatetraenoic Acids; D008024:Ligands; D011956:Receptors, Cell Surface; D044042:Receptors, Formyl Peptide; D018077:Receptors, Leukotriene; D044067:Receptors, Lipoxin