HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson's disease.
HLA-DR2 haplotype and DQ1 DNA alleles, characterizing 90 to 100% of all narcoleptic patients, were found to be equally distributed in 20 Parkinson's disease (PD) patients with early hallucinations, rapid eye movement (REM) sleep-related behaviour disturbances (RBD), and sleep onset in REM (SOREM), and in 20 PD patients without hallucinations, despite 10 to 15 years of treatment, and no RBD or SOREM.
Onofrj
Marco
M
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Luciano
Anna Lisa
AL
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Iacono
Diego
D
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Thomas
Astrid
A
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Stocchi
Fabrizio
F
Department of Oncology and Neuroscience, Movement Disorders Center, Neurophysiopathology, Università G. D'Annunzio, Chieti-Pescara, Italy.
Papola
Franco
F
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy.
Adorno
Domenico
D
Regional Center for Immunohaematology and Tissue Typing, National Council of Research, L'Aquila, Italy.
Di Mascio
Rocco
R
Institute of Medical Statistics. Università G. D'Annunzio, Chieti-Pescara, Italy.
D000368:Aged; D002352:Carrier Proteins / Q000235:genetics; D005260:Female; D015802:HLA-DR2 Antigen / Q000235:genetics; D006212:Hallucinations / Q000175:diagnosis / Q000235:genetics*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D018832:Molecular Chaperones; D010300:Parkinson Disease / Q000235:genetics*; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis / Q000235:genetics*; D012494:Sampling Studies
D002352:Carrier Proteins; D015802:HLA-DR2 Antigen; D018832:Molecular Chaperones; C108175:TOR1A protein, human; C491547:TOR1B protein, human