title: A comparison study of early non-psychotic deviant behavior in Afrikaner and US patients with schizophrenia or schizoaffective disorder.
abstract: In a previous study early non-psychotic deviant behaviors in US adult schizophrenic patients recruited for a large-scale genetic study were examined (Psychiatry Research, 101, 101). Early deviance characterized a distinct subgroup of patients at rates that were consistent with earlier reports. In addition, specific early non-psychotic deviant behaviors were meaningfully associated with later disease outcomes. In the present study, we examined the demographic, syndrome course, symptom and early deviant behavior history of 109 Afrikaner probands who met criteria for DSM schizophrenia or schizoaffective disorder, and compared them to 109 age- and gender-matched US probands. Consistent with past findings, 68% of Afrikaner probands, as compared to 67% of age- and gender-matched US probands, reported one or more forms of early non-psychotic deviance, including poor socialization, extreme fears/chronic sadness, and/or attention/learning impairment. The remaining 32 and 33% of probands, respectively, were without behavioral deviance until the onset of schizophrenia or schizoaffective disorder. The frequency and distribution of individual deviant behaviors were strikingly consistent between the samples. However, logistic regression analyses revealed different patterns of associations between the early deviant behaviors manifested and disease outcome. Afrikaner participants with early fears/chronic sadness were 3 times more likely to attempt suicide, while among US participants, this form of early deviance conferred 3.5 times more risk for later schizoaffective disorder, and 3 times greater likelihood of later sensory (tactile and/or olfactory) hallucinations. Afrikaner participants with attention/learning impairment were 2.5 times more likely to experience later auditory hallucinations, while US participants with these early difficulties were 3 times more likely to experience thought disorder. We concluded that early non-psychotic childhood deviance in this independently collected Afrikaner population distinguished a distinct subtype of patients and that the forms of early deviance manifested were meaningfully linked to later disease outcome. Possible reasons for the association pattern differences in these two populations are considered.
authors.affiliation: Laboratory of Human Neurogenetics, Rockefeller University, 1230 York Avenue, Box 313, New York, NY 10021, USA. sobinc@rockvax.rockefeller.edu
authors.forename: Christina
authors.initials: C
authors.lastname: Sobin
authors.forename: J Louw
authors.initials: JL
authors.lastname: Roos
authors.forename: Herman
authors.initials: H
authors.lastname: Pretorius
authors.forename: Laura S
authors.initials: LS
authors.lastname: Lundy
authors.forename: Maria
authors.initials: M
authors.lastname: Karayiorgou
mesh_terms: D000328:Adult; D001288:Attention; D003702:Delusions / Q000208:ethnology / Q000209:etiology; D005239:Fear; D005260:Female; D006212:Hallucinations / Q000208:ethnology / Q000209:etiology; D006801:Humans; D007859:Learning Disabilities / Q000208:ethnology / Q000209:etiology; D008297:Male; D001523:Mental Disorders / Q000208:ethnology* / Q000209:etiology*; D011618:Psychotic Disorders / Q000208:ethnology* / Q000523:psychology*; D012559:Schizophrenia / Q000208:ethnology*; D012565:Schizophrenic Psychology; D017678:Sex Distribution; D012951:Socialization; D013019:South Africa / Q000453:epidemiology; D014481:United States / Q000453:epidemiology