title: Effects of Alzheimer's disease on the recognition of novel versus familiar words: neuropsychological and clinico-metabolic data.
abstract: This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995) procedure. Results showed that both groups exhibited more hits and more false alarms for familiar than for novel words. The groups did not differ in the recognition of familiar words, reflecting preserved familiarity processes in AD. However, AD patients made more false alarms than NCs in the recognition of novel words, reflecting impairment of recollection processes in AD. A positron emission tomography analysis of clinico-metabolic correlations in AD patients showed a correlation between recognition of novel words and right hippocampal activity, whereas recognition of familiar words was more related to metabolic activity in the left posterior orbitofrontal cortex.
authors.affiliation: U Liège.
authors.forename: Françoise
authors.initials: F
authors.lastname: Lekeu
authors.affiliation: U Liège.
authors.forename: Martial
authors.initials: M
authors.lastname: Van der Linden
authors.affiliation: U Liège.
authors.forename: Christian
authors.initials: C
authors.lastname: Degueldre
authors.affiliation: U Liège.
authors.forename: Christian
authors.initials: C
authors.lastname: Lemaire
authors.affiliation: U Liège.
authors.forename: André
authors.initials: A
authors.lastname: Luxen
authors.affiliation: U Hosp of Liège.
authors.forename: Georges
authors.initials: G
authors.lastname: Franck
authors.affiliation: U Liège.
authors.forename: Gustave
authors.initials: G
authors.lastname: Moonen
authors.affiliation: U Liège.
authors.forename: Eric
authors.identifier: 0000-0003-2520-9241
authors.initials: E
authors.lastname: Salmon
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology*; D001931:Brain Mapping; D003210:Concept Formation / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D012153:Retention, Psychology / Q000502:physiology; D014055:Tomography, Emission-Computed; D014706:Verbal Learning / Q000502:physiology*