title: Do obsessive-compulsive patients and abstinent heroin addicts share a common psychophysiological mechanism?
abstract: OBJECTIVE
  Working memory (WM) and attentional deficits have been implicated in the pathophysiology of both obsessive-compulsive disorder (OCD) and opioid addiction. The P300 component of event-related potentials (ERPs) is considered as an index of on-line updating of WM and/or attentional operations involved in this function. The present study aimed at comparing the P300 elicited during a WM test in patients with prolonged heroin abstinence, those with OCD and healthy controls, in order to demonstrate possibly common underlying psychophysiological mechanisms.
  
  
  METHODS
  The P300 component was evaluated during the anticipatory period of a WM test in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 OCD patients, and 20 healthy subjects matched for age, sex and educational level.
  
  
  RESULTS
  The two patient groups showed a considerable reduction of the P300 amplitudes, located at the right frontal area as compared with healthy controls. The abstinent heroin addicts exhibited a significantly lower P300 amplitude at central frontal areas and a significantly higher P300 amplitude at the left occipital region relative to the other two groups. Furthermore, the abstinent group showed a notable delay of P300 latency relative to controls and OCD patients at the right occipital region. Moreover, the OCD patients manifested a significant prolongation of P300 located at the central prefrontal area, relative to addicts and healthy controls.
  
  
  CONCLUSIONS
  These findings point to considerable WM and/or attentional deficits in the long-term abstinent syndrome of heroin misuse and OCD associated with distributed and prefrontal cortical circuits, respectively. Furthermore, the present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.
authors.affiliation: Department of Psychiatry, Eginition Hospital, University of Athens, 74 Vas Sophias Ave., Athens, 11528 Greece. panchris@otenet.gr
authors.forename: Charalabos
authors.initials: C
authors.lastname: Papageorgiou
authors.forename: Andreas
authors.initials: A
authors.lastname: Rabavilas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
authors.forename: Costas
authors.initials: C
authors.lastname: Stefanis
mesh_terms: D000328:Adult; D001288:Attention; D018913:Event-Related Potentials, P300; D005260:Female; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008568:Memory; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D011930:Reaction Time; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
chemical_list: D003932:Heroin