Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection.
A precise and accurate FIA method for the quantification of nabumetone (NAB) in pharmaceuticals is described. The best suitable carrier solvent system consisted of ethanol: water (30:70 v/v). Sample solution (4.7 x 10(-6) M NAB) was prepared in this solvent and injected to the instrumental system at a flow rate of 1.2 ml x min(-1). The signals were detected by a UV detector at 228.8 nm. The calibration curves of NAB was linear in the concentration range of 1.4 x 10(-6) M-2.8 x 10(-5) M. The intra- and inter-assay precision were less than 2.6%. The method exhibited a good linearity with the correlation coefficients. The LOD and LOQ values were found to be 4.4 x 10(-7) and 1.3 x 10(-6) M, respectively. The effects of the tablet excipients were insignificant at the 95% probability level. The calculated tablet content was 99% which is agreement with the ranges stated by pharmacopoeias.
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Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Tuncel
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Aboul-Enein
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HY
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002074:Butanones / Q000032:analysis*; D017022:Flow Injection Analysis; D000077430:Nabumetone; D015203:Reproducibility of Results; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D012996:Solutions; D013607:Tablets; D000077430:Nabumetone