[Effects of xuefuzhuyu decoction on collagen synthesis and proliferation of cardiac fibroblasts].
OBJECTIVE
To study the effects of XueFuZhuYu Decoction (XFZYD) on collagen synthesis and proliferation of cardiac fibroblasts and provide academic bases of remedying kinds of heart disease aroused by proliferation of cardiac fibroblasts.


METHODS
By adding medicine directly and serum pharmacological method.


RESULTS
Compared with the control group, 1 g/ml XFZYD(dilution 1:80) and 10 percent serum of rat contained XFZYD could significantly inhibit the collagen synthesis and the proliferation of cardiac fibroblasts. Moreover, 1 g/ml XFZYD(dilution 1:80) could significantly affect collagen secrtion of cardiac fibroblasts (P < 0.05), up to 17.9%.


CONCLUSIONS
XFZYD could inhibit both proliferation and collagen secretion of cardiac fibroblasts. It could resist cardiac muscle fibrosis.
Ding
Zhishan
Z
Molecular Medical Institute, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053.
Gao
Chengxian
C
Ji
Ruirui
R
Wo
Xingde
X
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry*; D027861:Prunus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032267:Rehmannia / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D003094:Collagen