title: [Synthesis of hirsutrin and hyperin]
abstract: OBJECTIVE: To investigate an easier method for preparation of hirsutrin and hyperin. METHODS: Rutin was utilized as the starting material. The target compounds were produced via benzoylation, hydrolysis, glycosidation and deproteination. RESULTS: The yield of key intermediate 5,7,3',4'-tetra-O-benzoyl quercetin was improved by reducing the hydrolysis time of 5,7,3',4'-tetra-O-benzoyl rutin in HCl/EtOH. Hirsutrin and hyperin were synthesized. CONCLSION: Hirsutrin can be synthesized and the yield of hyperin improved by this method.
authors.affiliation: College of Pharmacy, Zhejiang University, Hangzhou 310031, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Yong-Zhou
authors.initials: YZ
authors.lastname: Hu