Loniceroside C, an antiinflammatory saponin from Lonicera japonica.
A new triterpenoid saponin, loniceroside C was isolated from the aerial parts of Lonicera japonica. Its structure was established to be 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-xylopyranosyl(1-->6)]-beta-D-glucopyranosyl ester by spectroscopic techniques and chemical transformations. Loniceroside C showed in vivo antiinflammatory activity against mouse ear edema provoked by croton oil.
Kwak
Wie Jong
WJ
SK Chemicals Ltd., Suwon, Korea.
Han
Chang Kyun
CK
Chang
Hyeun Wook
HW
Kim
Hyun Pyo
HP
Kang
Sam Sik
SS
Son
Kun Ho
KH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006027:Glycosides; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D031239:Lonicera; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; C420335:loniceracetalide A