title: [Renal carcinoma with invasion of the suprahepatic vena cava (Staehler stage III and IV): surgical treatment and results].
abstract: The operative treatment of patients with renal cell carcinoma (RCC) and suprahepatic infradiaphragmatic or supradiaphragmatic vena cava invasion (Staehler stage III and IV) is still an interdisciplinary challenge. The potential high complication rate and the enormous operative-technical efforts have to be brought into line with the individual benefit for the patient. In this study, we have retrospectively analyzed the operative results of 24 patients. We have further compared the patients during follow-up and immunotherapy due to metastasis with a control group of 75 patients without vena cava invasion. Perioperative mortality in the 24 patients was 4%. Four patients had metastasis at presentation and 14 further patients developed metastatic disease during median follow-up of 23.5 months. Median survival was 45 months with a 1-, 3-, and 5-year survival rate of 92, 57, and 33%, respectively. In a multivariate analysis, only the presence of metastasis (p=0.002) and marginal immunotherapy (p=0.1), but not vena cava invasion (p=0.259) or a positive lymph node status (p=0.624) were significant predictors of a poor survival. For patients with RCC and suprahepatic infradiaphragmatic or supradiaphragmatic vena cava invasion (Staehler stage III and IV), the combination of an aggressive surgical treatment combined with subsequent immunotherapy in the presence of metastatic disease offers a realistic therapeutic option with reasonable survival rates.
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Charité, Medizinsche Fakultät, Humbolt-Universität, Berlin. jan.roigas@charite.de
authors.forename: J
authors.initials: J
authors.lastname: Roigas
authors.forename: A
authors.initials: A
authors.lastname: Wille
authors.forename: K
authors.initials: K
authors.lastname: Winter
authors.forename: S
authors.initials: S
authors.lastname: Deger
authors.forename: I
authors.initials: I
authors.lastname: Türk
authors.forename: R I
authors.initials: RI
authors.lastname: Rückert
authors.forename: J
authors.initials: J
authors.lastname: Bohm
authors.forename: D
authors.initials: D
authors.lastname: Schnorr
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008197:Lymph Node Excision / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D009392:Nephrectomy / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D019043:Vascular Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D014683:Vena Cava, Superior / Q000473:pathology / Q000601:surgery*