title: The 'common mole' from the point of view of digital dermoscopy analysis: subjective vs. objective evaluation of easy pigmented skin lesions.
abstract: BACKGROUND
  The term 'common mole', often used to describe a subset of benign pigmented skin lesions, is traditionally defined on the basis of morpho-chromatic features. In recent years, certain research groups have developed equipment and methods, such as digital dermoscopy analysis, that enable objective evaluation of pigmented skin lesions.
  
  
  OBJECTIVE
  In this study we use a digital dermoscopy analyser trained for the recognition of pigmented skin lesions to compare the subjective definition of 'common' and the mathematical concept of 'close to the mean of measurements'.
  
  
  METHODS
  A subset (100) of digital images of flat pigmented lesions, obtained in daily practice, were classified by trained and non-expert clinicians as common moles (60) or clear-cut melanoma (40), and processed with a DB-Mips analyser. The resulting parameters, validated by a classifier, were used to evaluate Hotelling's T2 multivariate distances from the mean.
  
  
  RESULTS
  'Common' moles could not be clearly defined in terms of closeness to the means of objectively evaluated parameters. Their diagnosis indudes many other evaluations and clusters of variables.
  
  
  CONCLUSIONS
  The clinical semantics of the term 'common' does not conform to any unambiguous mathematical definition.
authors.affiliation: Department of Dermatology, University of Siena, Siena, Italy. rubegni@unisi.it
authors.forename: M
authors.initials: M
authors.lastname: Burroni
authors.forename: P
authors.initials: P
authors.lastname: Rubegni
authors.forename: G
authors.initials: G
authors.lastname: Dell'eva
authors.forename: S
authors.initials: S
authors.lastname: Santini
authors.forename: R
authors.initials: R
authors.lastname: Perotti
authors.forename: M
authors.initials: M
authors.lastname: Biagioli
authors.forename: P
authors.initials: P
authors.lastname: Taddeucci
authors.forename: L
authors.initials: L
authors.lastname: Andreassi
mesh_terms: D003936:Diagnosis, Computer-Assisted; D016002:Discriminant Analysis; D006801:Humans; D008163:Luminescent Measurements; D008545:Melanoma / Q000473:pathology*; D009506:Nevus / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*