The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine.
This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.
Boselli
Emmanuel
E
*†Department of Anesthesiology and Intensive Care, Hôpital de l'Hôtel-Dieu, Lyon; and ‡§Laboratory of Glycobiology, Unité INSERM 346, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Duflo
Frédéric
F
Debon
Richard
R
Allaouchiche
Bernard
B
Chassard
Dominique
D
Thomas
Luc
L
Portoukalian
Jacques
J
D000577:Amides / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005434:Flow Cytometry; D006801:Humans; D019169:Jurkat Cells; D008012:Lidocaine / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000378:metabolism; D000077212:Ropivacaine
D000577:Amides; D000779:Anesthetics, Local; D010718:Phosphatidylserines; D000077212:Ropivacaine; D008012:Lidocaine