Parimycin: isolation and structure elucidation of a novel cytotoxic 2,3-dihydroquinizarin analogue of gamma-indomycinone from a marine streptomycete isolate.
In our screening of actinomycetes from the marine environment for bioactive components, a new antibiotic with a novel structure designated as parimycin was obtained from the culture broth of Streptomyces sp. isolate B8652. The structure of the new antibiotic was determined by spectroscopic methods and by comparison of the NMR data with those of the structurally related gamma-indomycinone.
Maskey
Rajendra P
RP
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, Göttingen D-37077, Germany.
Helmke
Elisabeth
E
Fiebig
Heinz-Herbert
HH
Laatsch
Hartmut
H
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002965:Classification; D004353:Drug Evaluation, Preclinical / Q000379:methods; D056890:Eukaryota / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry; D013302:Streptomyces / Q000145:classification / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014871:Water Microbiology
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D011753:Pyrones; C094791:gamma-indomycinone; C472171:parimycin