[Clinical development of anti-angiogenic agents in 2002].
In 2002, new developments in anti-angiogenic strategies encompassed two main aspects. Firstly, essential improvements were made in the field of methodology : novel techniques permitted to measure directly on patients the biological effects induced by anti-angiogenic treatments in the course of clinical trials. Secondly, results of the first phase I trials of endostatin, one of the most awaited anti-angiogenic drugs, were published. These studies proved that endostatin was not toxic and that doses equivalent to the one effective in animals could safely be used in man, but efficacy results were not up to expectations. On the other hand, treatment targeting the VEGF pathway, and especially humanised anti-VEGF monoclonal antibody, had promising results. Further clinical trials are needed to gain clear insight into the precise role of those promising strategies for the management of solid tumours.
Bachelot
Thomas
T
Unité Cytokines et Cancers, Inserm U453, Centre Léon-Bérard, 28, rue Laennec, 69373 Lyon cedex 08. bachelot@lyon.fnclcc.fr
Jouanneau
Emmanuel
E
Blay
Jean-Yves
JY
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D017321:Clinical Trials, Phase I as Topic; D003094:Collagen / Q000008:administration & dosage* / Q000009:adverse effects; D043169:Endostatins; D016228:Endothelial Growth Factors / Q000037:antagonists & inhibitors*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines / Q000037:antagonists & inhibitors*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000009:adverse effects; D011758:Pyrroles / Q000008:administration & dosage* / Q000009:adverse effects; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D043169:Endostatins; D016228:Endothelial Growth Factors; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D010446:Peptide Fragments; D011758:Pyrroles; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C116890:Semaxinib; D003094:Collagen