Inhibitory effects of Vietnamese medicinal plants on tube-like formation of human umbilical venous cells.
Seven of 58 plant materials from Vietnamese medicinal plants showed strong to moderate inhibitory activity on the tube-like formation induced by human umbilical venous endothelial cells in the in vitro angiogenesis assay. These plant materials include the herb of Ephedra sinica, leaves and stem of Ceiba pentandra, seed of Coix lachryma-jobi, rhizome of Drynaria fortunei, fruits and stem of Illicium verum and stem of Bombax ceiba. Of these, the methanol extracts of the herb of Ephedra sinica and stem of -Ceiba pentandra exhibited the strongest activities with inhibition percentages of 89.3% and 87.5% at 30 and 100 microgram/mL, respectively.
Nam
Nguyen-Hai
NH
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea.
Kim
Hwan-Mook
HM
Bae
Ki-Hwan
KH
Ahn
Byung-Zun
BZ
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D018517:Plant Roots; D018547:Plant Stems; D010946:Plants, Medicinal; D012639:Seeds; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014471:Umbilical Veins / Q000166:cytology* / Q000187:drug effects*; D014744:Vietnam
D020533:Angiogenesis Inhibitors; D010936:Plant Extracts