title: Analysis of malignancy-associated DNA changes in the nuclei of buccal epithelium in the pathology of the thyroid and mammary glands.
abstract: The object of the investigation reported in this paper was to study, from the point of view of statistical and geometric theory of pattern recognition, the DNA optical density distribution peculiarities in the interphase nuclei of buccal epithelium present in the pathology of the thyroid and mammary glands. Two new indices to characterize this distribution (ratio of modal class volumes and relief index) are proposed. It is shown that in malignant neoplasms of the thyroid and mammary glands the changes in the nuclei of buccal epithelium are characterized by an increase in the optical density of DNA over a range from 0.15 to 0.30 in conventional units of measure, as compared with its values in benign pathological processes. The sensitivity of the proposed criterion for diseases of the thyroid gland is equal to 76.2% and the specificity is equal to 85.8%. For diseases of the mammary gland (excluding IDLC) we have discovered that the sensitivity of the method is equal to 94.29% and its specificity equal to 90.91%. In diseases of the mammary gland (including IDLC) we have discovered that the sensitivity of the method is equal to 71.42% and its specificity is equal to 90.91%.
authors.affiliation: Department of Cybernetics, Kyiv National Shevchenko University, Ukraine.
authors.forename: D A
authors.initials: DA
authors.lastname: Klyushin
authors.forename: Yu I
authors.initials: YI
authors.lastname: Petunin
authors.forename: R I
authors.initials: RI
authors.lastname: Andrushkiw
authors.forename: N V
authors.initials: NV
authors.lastname: Boroday
authors.forename: K P
authors.initials: KP
authors.lastname: Ganina
mesh_terms: D001699:Biometry / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000235:genetics*; D005260:Female; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology*; D010363:Pattern Recognition, Automated; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D004247:DNA