Different subtype distributions in two cities in Myanmar: evidence for independent clusters of HIV-1 transmission.
A molecular epidemiological investigation was conducted in two major cities in Myanmar (Yangon and Mandalay). The study revealed a unique predominance of HIV-1 subtype B' (Thailand variant of subtype B) among injecting drug users in Yangon, indicating the strong founder effect of this variant. In contrast, multiple lineages of HIV-1 strains were found in Mandalay, leading to the evolution of various forms of intersubtype recombinants. The results showed independent clusters of HIV-1 transmission in Myanmar.
Motomura
Kazushi
K
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Kusagawa
Shigeru
S
Lwin
Hla Htut
HH
Thwe
Min
M
Kato
Kayoko
K
Oishi
Kazunori
K
Yamamoto
Naoki
N
Zaw
Myint
M
Nagatake
Tsuyoshi
T
Takebe
Yutaka
Y
D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D002052:Myanmar / Q000453:epidemiology; D017423:Sequence Analysis, RNA; D015819:Substance Abuse, Intravenous