Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula.
Extensive fractionation of the crude organic extract from a Puerto Rican collection of Lyngbya majuscula led to the discovery of three new secondary metabolites: a quinoline alkaloid (1), malyngamide T (2), and a tryptophan derivative (3). In addition, several previously reported compounds, including the potent neurotoxins antillatoxin, antillatoxin B, and kalkitoxin, were identified. The structures of 1, 2, and 3 were deduced by NMR and mass spectral data interpretation and suggest the existence of a convergent biosynthetic pathway for these new and unusual metabolites.
Nogle
Lisa M
LM
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Gerwick
William H
WH
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000458:Cyanobacteria / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011647:Puerto Rico; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*
D000470:Alkaloids; D011804:Quinolines; D014364:Tryptophan