title: Recoverin and rhodopsin kinase.
abstract: The majority of proteins involved in vertebrate phototransduction are expressed specifically in photoreceptors. Recoverin and rhodopsin kinase are expressed primarily in retinal photoreceptors and they interact with each other in a Ca2+-dependent manner. This Ca2+-dependent interaction has been studied extensively in vitro. Experiments utilizing animal models and electrophysiological approaches have started to provide important insight regarding its invivo function. Recoverin can be viewed as a negative regulator of rhodopsin kinase in vertebrate phototransduction. This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery.
authors.affiliation: Department of Ophthalmology, University of Utah, Salt Lake City, UT 84112-5330, USA. jason@hmbg.utah.edu
authors.forename: Ching-Kang Jason
authors.initials: CK
authors.lastname: Chen
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D004594:Electrophysiology; D005136:Eye Proteins; D051606:G-Protein-Coupled Receptor Kinase 1; D051597:Hippocalcin; D006801:Humans; D008027:Light; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology*; D017434:Protein Structure, Tertiary; D051603:Recoverin; D015398:Signal Transduction
chemical_list: D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D011494:Protein Kinases; D051606:G-Protein-Coupled Receptor Kinase 1; C496764:GRK1 protein, human; D002118:Calcium