The controlled release study of Vincristine Sulfate.
We prepared microspheres of Vincristine Sulfate (VCR) through drying-from-oil method, then mixed the microspheres into 0.7% collagen swelling solution to prepare emulsion, spread the emulsion on plate to form film by frozen-dry method. The film was cross-linked and sterilized, then planted into the site of tumor and expected to release at steady speed. We measured the release of VCR in vivo and in vitro by HPLC. The results demonstrated that VCR controlled release films release at approximate steady speed in 15 days.
Sun
Yong
Y
National Pharmaceutical Research Center, Lunan Pharmaceutical Corporation, Linyi City, Shandong, China.
Xu
Lisa
L
Zhang
Qiqing
Q
Zhou
Haiying
H
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D003094:Collagen; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods; D008863:Microspheres; D014750:Vincristine / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D014750:Vincristine; D003094:Collagen