title: Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate solutions.
abstract: An ethylene-vinyl alcohol copolymer (EVOH) was treated with a silane coupling agent and calcium silicate solutions, and then soaked in a simulated body fluid (SBF) with ion concentrations approximately equal to those of human blood plasma. A smooth and uniform bonelike apatite layer was successfully formed on both the EVOH plate and the EVOH-knitted fibers in SBF within 2 days. Part of the structure of the resulting apatite-EVOH fiber composite was similar to that of natural bone. If this kind of composite can be fabricated into a three-dimensional structure similar to natural bone, the resultant composite is expected to exhibit both mechanical properties analogous to those of natural bone and bone-bonding ability. Hence, it has great potential as a bone substitute.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. a-oyane@aist.go.jp
authors.forename: Ayako
authors.initials: A
authors.lastname: Oyane
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
authors.forename: Masahiko
authors.initials: M
authors.lastname: Minoda
authors.forename: Takeaki
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D001031:Apatites / Q000737:chemistry*; D001826:Body Fluids; D018786:Bone Substitutes / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011145:Polyvinyls / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D017640:Silicates / Q000737:chemistry; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis; D013499:Surface Properties; D014965:X-Rays
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D017610:Calcium Compounds; D011145:Polyvinyls; D012821:Silanes; D017640:Silicates; D012996:Solutions; C020320:ethylene-vinyl alcohol copolymer; C031293:calcium silicate