[Effect of haloperidol on development of amnesia in aggressive and submissive mice].
The effect of haloperidol on the passive avoidance habit retrieval upon amnesia was studied in C57BL/6J mice with aggressive and submissive behavioral stereotypes formed under agonist confrontation conditions. In the control (untreated) group, the efficacy of the amnesic action of detention in the dangerous compartment on the learning day was reduced for the aggressive stereotype as compared to the submissive one. In the aggressive mice, the administration of haloperidol (0.5 mg/kg) one hour before learning deteriorated the conditional reaction retrieval between 2nd and 13th days of test. In the submissive mice, the administration of haloperidol produced a prolonged antiamnesic effect. Thus, the effect of haloperidol on the violated memory trace reproduction depends on the individual behavioral state.
Dubrovina
N I
NI
Laboratory of Memory Regulation Mechanisms, Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, ul. Timakova, 4, Novosibirsk, 630117 Russia.
Loskutova
L V
LV
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000633:toxicity; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D014150:Antipsychotic Agents; D006220:Haloperidol