[Conjugated polymer-subunit immunogens and vaccines].
A study of fundamental mechanisms regulating the immune response resulted in producing a theory explaining the mechanism of immunostimulating properties of polyelectrolytes, as well as in working out the principles for creating the synthetic immunomodulators and, on the basis of them, polymer-subunit immunogens and vaccines. The above theory produced a basis for creating polyoxidonium, a new polymer polyelectrolyte, which was used to synthesize the conjugated polymer-subunit "Grippol" vaccine that, after its commissioning into production, has been widely used.
Petrov
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Khaitov
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D000276:Adjuvants, Immunologic; D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D007252:Influenza Vaccines / Q000737:chemistry / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology; D010586:Phagocytes / Q000276:immunology; D011108:Polymers; D014613:Vaccines, Attenuated / Q000276:immunology; D022223:Vaccines, Subunit
D000276:Adjuvants, Immunologic; C408342:Grippol; D007252:Influenza Vaccines; D011108:Polymers; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit