t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia.
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.
Vizmanos
José L
JL
Department of Genetics, School of Science, University of Navarra, C/Irunlarrea s/n, 31080 Pamplona, Spain. jlvismanos@unav.es
Larráyoz
María J
MJ
Lahortiga
Idoya
I
Floristán
Filomena
F
Alvarez
Carmen
C
Odero
María D
MD
Novo
Francisco J
FJ
Calasanz
María J
MJ
D000123:Acetyltransferases / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D050882:CREB-Binding Protein; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D017809:Fatal Outcome; D051548:Histone Acetyltransferases; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics
D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D000123:Acetyltransferases; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; D051548:Histone Acetyltransferases