The adaptive effects of hypoxic preconditioning of brain neurons.
Prophylactic transient hypoxia (preconditioning) increased neuron resistance to subsequent induction of severe hypoxia. Published data and results obtained by the authors on the molecular-cellular mechanisms of hypoxic preconditioning are presented. The roles of intracellular signal transduction, genome function, stress proteins, and neuromodulatory peptides in this process are discussed. The roles of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulatory factors as components of "volume" signal transmission are analyzed in hypoxic preconditioning-associated induction of functional tolerance mechanisms against the acute harmful effects of hypoxia on neurons in olfactory slices.
Samoilov
M O
MO
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
Lazarevich
E V
EV
Semenov
D G
DG
Mokrushin
A A
AA
Tyul'kova
E I
EI
Romanovskii
D Yu
DY
Milyakova
E A
EA
Dudkin
K N
KN
D000220:Adaptation, Biological / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D015687:Cell Hypoxia; D016678:Genome; D006801:Humans; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents; D010100:Oxygen / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D018377:Neurotransmitter Agents; D010100:Oxygen