title: Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents.
abstract: [formula: see text] The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxilliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Bream
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Panayiotis A
authors.initials: PA
authors.lastname: Procopiou