title: Adrenocortical tumors: results of treatment and study of Weiss's score as a prognostic factor.
abstract: OBJECTIVE
  The differential diagnosis between benign and malignant adrenal cortical tumors circumscribed to the gland is controversial. One hundred and seven patients with adrenal cortex tumors (excluding those with primary hyperaldosteronism) were studied to assess the 5-year survival rate of adults, children, patients stratified by pathological stage, and patients stratified according to Weiss's score of <3 or >3.
  
  
  METHODS
  The patients were evaluated both clinically and biochemically. One hundred and five patients underwent surgery and were classified pathologically as stages I, II, III, or IV. The tumors were weighed, measured, and classified according to Weiss's criteria and divided into 2 groups: <3 and >3.
  
  
  RESULTS
  After 5 years, the survival rate was 77.5% for the whole group, 74.61% for the adults, 84.3% for the children, 100% for stage I, 83.9% for stage II, 33% for stage III, and 11.7% for stage IV groups. Additionally, after 5 years, 100% of the patients with tumors with Weiss's score <3 were alive compared to 61.65% of those with Weiss's score >3. The average weights of the tumors of score <3 and >3 were 23.38 g   41.36 g and 376.3   538.76 g, respectively, which is a statistically significant difference. The average sizes of tumors of Weiss's score <3 and >3 were 3.67   2.2 cm and 9.64   5.8 cm, respectively, which is also a statistically significant difference.
  
  
  CONCLUSIONS
  Weiss's score may be a good prognostic factor for tumors of the adrenal cortex. Additionally, there was a statistically significant difference between the average weight and size of tumors with benign behavior (Weiss's score <3) and those with malignant behavior (Weiss's score >3).
authors.affiliation: Department of Urology, Endocrinology and Pathology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
authors.forename: Antonio Marmo
authors.initials: AM
authors.lastname: Lucon
authors.forename: Maria Adelaide
authors.initials: MA
authors.lastname: Pereira
authors.forename: Berenice B
authors.initials: BB
authors.lastname: Mendonça
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Zerbini
authors.forename: Luiz B
authors.initials: LB
authors.lastname: Saldanha
authors.forename: Sami
authors.initials: S
authors.lastname: Arap
mesh_terms: D000236:Adenoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018268:Adrenocortical Carcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate