[Improvement of learning and memory functions by rice flavoids in mice].
OBJECTIVE
To observe the effects of rice flavoids (RF) on learning and memory functions.


METHODS
The step down test and the step through test in mice were used.


RESULTS
RF could significantly improve the learning and memory ability in many dementia models, such as the impairment of acquisition of memory mice induced by M-anticholinergic agents like anisodine, the impairment of consolidation of memory in mice induced by protein biosynthesis inhibitors like actidione, the impairment of retrieval of memory in mice induced by central neuron system(CNS) depressants like ethanol, mice after cerebral ischemia-reperfusion.


CONCLUSIONS
It is suggested that RF can markedly enhance the learning and memory ability, and that is significant to prevent and cure the senile dementia.
He
Rongfei
R
Department of Pharmacy, Zhongshan University, Guangzhou 510275.
Mei
Xueting
X
Xu
Donghui
D
Xu
Shibo
S
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology; D051379:Mice; D012275:Oryza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D005419:Flavonoids