title: Familial clustering of hepatitis B infection: study of a family.
abstract: Familial clustering of hepatitis B virus infection has been reported infrequently. We report a family of 27 members, where 13 members were HBsAg-positive. This included 7 of 10 members in one linear family across four generations. Nine subjects who were tested were HBeAg-negative. Of these nine, three subjects had elevated ALT; histology in one of them showed activity index <3. One subject received lamivudine therapy elsewhere; ALT levels returned to normal in two months.
authors.affiliation: Department of Gastroenterology, Seth G S Medical College and K E M Hospital, Mumbai 400 012.
authors.forename: Govind
authors.initials: G
authors.lastname: Verma
authors.forename: Prakash
authors.initials: P
authors.lastname: Dalai
authors.forename: Mukta
authors.initials: M
authors.lastname: Bapat
authors.forename: Pravin
authors.initials: P
authors.lastname: Rathi
authors.forename: Philip
authors.initials: P
authors.lastname: Abraham
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D016000:Cluster Analysis; D005260:Female; D006509:Hepatitis B / Q000235:genetics*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D006514:Hepatitis B Surface Antigens