Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice.
We investigated whether fenofibrate improves lipid metabolism and obesity in female ovariectomized (OVX) or sham-operated (SO) low density lipoprotein receptor-null (LDLR-null) mice. All mice fed a high-fat diet exhibited increases in serum triglycerides and cholesterol as well as in body weight and white adipose tissue (WAT) mass compared to mice fed a low fat control diet. However, fenofibrate prevented high-fat diet-induced increases in body weight and WAT mass in female OVX LDLR-null mice, but not in SO mice. In addition, administration of fenofibrate reduced serum lipids and hepatic apolipoprotein C-III mRNA while increasing the mRNA of acyl-CoA oxidase in both groups of mice, however, these effects were more pronounced in OVX LDLR-null mice. The results of this study provide first evidence that fenofibrate improves both lipid metabolism and obesity, in part through PPARalpha activation, in female OVX LDLR-null mice.
Yoon
Michung
M
Department of Life Sciences, Mokwon University, Taejon 302-729, South Korea. yoon60@mokwon.ac.kr
Jeong
Sunhyo
S
Lee
Hyunghee
H
Han
Miyoung
M
Kang
Joo Hyoung
JH
Kim
Eun Young
EY
Kim
Mina
M
Oh
Goo Taeg
GT
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D011345:Fenofibrate / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000188:drug therapy*; D009929:Organ Size; D010052:Ovariectomy; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics
D018160:Receptors, Cytoplasmic and Nuclear; D011973:Receptors, LDL; D014157:Transcription Factors; D011345:Fenofibrate