The transformation of the model organism: a decade of developmental genetics.
The past decade has seen the development of powerful techniques to dissect the molecular processes that regulate development. New tools have been used to reveal the basis of cell polarity, morphogen gradients and regulation of signaling in developing animals. Cell biology and developmental biology have become closely intertwined, and many genes that had been thought of as regulators of general cell biological (housekeeping) functions have been shown to act as specific developmental regulators. Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development.
Anderson
Kathryn V
KV
Developmental Biology Program, Sloan-Kettering Institute, New York, New York 10021, USA. k-anderson@ski.mskcc.org
Ingham
Philip W
PW
D000818:Animals; D016764:Cell Polarity; D015509:Developmental Biology / Q000266:history / Q000639:trends; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D005246:Feedback; D005823:Genetics / Q000266:history / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D015398:Signal Transduction; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development