title: Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice.
abstract: In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.
authors.affiliation: Department of Biology, Georgetown University, Washington, D.C. 20057, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Erqiu
authors.initials: E
authors.lastname: Li
authors.forename: Nannan
authors.initials: N
authors.lastname: Zhu
authors.forename: Jason
authors.initials: J
authors.lastname: Robertson
authors.forename: Theodore
authors.initials: T
authors.lastname: Nash
authors.forename: Steven M
authors.initials: SM
authors.lastname: Singer
mesh_terms: D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D002908:Chronic Disease; D016829:Giardia lamblia / Q000276:immunology; D005873:Giardiasis / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis; D015850:Interleukin-6 / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D015850:Interleukin-6; D012333:RNA, Messenger