The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development.
We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.
Reedy
Mark V
MV
Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA. mreedy@creighton.edu
Johnson
Randy L
RL
Erickson
Carol A
CA
D000818:Animals; D002642:Chick Embryo; D005121:Extremities / Q000196:embryology*; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis / Q000235:genetics*; D019170:Somites / Q000378:metabolism*; D019089:Stem Cell Factor / Q000096:biosynthesis / Q000235:genetics*
D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit