[Fundamental aspects of extreme aging].
Major developments in molecular biology in invertebrates have recently shown the determining effect of genetics on aging. The first finding was that artificial selection can highlight the genetic aspect of the aging process, demonstrating the polygenetic property of longevity. Another finding showed that certain gene transfers can modulate the lifespan of an organism. Recent progress has been made in three fields: genetic markers of aging, biological basis of cell maintenance, and hereditary factors contributing to late onset genetic disease. These new developments open new avenues of research in clinical biology. In regard to genetic markers of aging, it has been demonstrated that the ends of the chromosomes, telomeres, play a role in cell senescence. Telomeres can be viewed as markers of aging. Shortened telomeres are associated with replicative senescence and antitumor action. DNA anomalies are also more frequent: simple or double breaks, additions and base substitutions. Data on the biological basis of cell maintenance obtained in invertebrates show the polygenetic property of aging involving four significant mechanisms, control of metabolism, resistance to stress, chromatin-dependent gene regulation of genetic homeostasis. Finally, recent studies have shown that late onset hereditary diseases would be linked with particular genes, some of which have been identified. Two non-exclusive mechanisms could be involved: an adaptive mechanism involving gene selection during the evolutionary process, for example in obesity; and non-adaptive accumulation of gene expression during the post-reproductive phase, for example in Alzheimer's disease. These findings open a new era for the biology of aging.
Tréton
J
J
Centre de Recherches Gérontologiques de l'Association Claude Bernard, INSERM U 450, Développement, Vieillissement et pathologie de la rétine, Institut de Recherche Biomédicale des Cordeliers, Bâtiment B, Paris. treton@infobiogen.fr
D000368:Aged; D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D016923:Cell Death; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D004777:Environment; D005260:Female; D005609:Free Radicals / Q000009:adverse effects; D006706:Homeostasis; D006801:Humans; D007448:Invertebrates / Q000235:genetics / Q000502:physiology; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000009:adverse effects; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016615:Telomere / Q000502:physiology; D014898:Werner Syndrome / Q000235:genetics
D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D005609:Free Radicals; D017382:Reactive Oxygen Species