Antigenotoxic potential of certain dietary constituents.
The human diet contains a variety of compounds that exhibit chemopreventive effects towards an array of xenobiotics. In the present study, the antigenotoxic potential of selected dietary constituents including Diallyl sulfide (DAS), Indole-3-carbinol (I3C), Curcumin (CUR), and Black tea polyphenols (BTP) has been evaluated in the Salmonella typhimurium reverse mutation and mammalian in vivo cytogenetic assays. In addition, the anticlastogenic effect of the above dietary constituents was identified towards Benzo(a)pyrene (BaP) and cyclophosphamide- (CP) induced cytogenetic damage in mouse bone marrow cells. The induction of BaP and CP induced chromosomal aberrations, micronuclei formation, and sister chromatid exchanges (SCEs) were found to be inhibited in a dose-dependent manner by DAS, I3C, CUR, and BTP. Thus the study reveals the antimutagenic potential of these dietary compounds towards BaP- and CP-induced genotoxicity in microbial and mammalian test systems.
Shukla
Yogeshwer
Y
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India. yogeshwershukla@hotmail.com
Arora
Annu
A
Taneja
Pankaj
P
D000498:Allyl Compounds / Q000494:pharmacology; D000818:Animals; D016587:Antimutagenic Agents; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids; D007211:Indoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D010636:Phenols / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013440:Sulfides / Q000494:pharmacology; D013662:Tea / Q000737:chemistry
D000498:Allyl Compounds; D016587:Antimutagenic Agents; D005419:Flavonoids; D007211:Indoles; D010636:Phenols; D011108:Polymers; D013440:Sulfides; D013662:Tea; D001564:Benzo(a)pyrene; C038491:allyl sulfide; D003520:Cyclophosphamide; C016517:indole-3-carbinol; D003474:Curcumin