title: Quantitative trait loci mapping of functional traits in the German Holstein cattle population.
abstract: A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breedingvalues for maternal and direct effects on dystocia (DYSm, DYSd) and stillbirth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.
authors.affiliation: Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, D-18196 Dummerstorf, Germany. kuehn@fbn-dummerstorf.de
authors.forename: Ch
authors.initials: Ch
authors.lastname: Kühn
authors.forename: J
authors.initials: J
authors.lastname: Bennewitz
authors.forename: N
authors.initials: N
authors.lastname: Reinsch
authors.forename: N
authors.initials: N
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Thomsen
authors.forename: C
authors.initials: C
authors.lastname: Looft
authors.forename: G A
authors.initials: GA
authors.lastname: Brockmann
authors.forename: M
authors.initials: M
authors.lastname: Schwerin
authors.forename: C
authors.initials: C
authors.lastname: Weimann
authors.forename: S
authors.initials: S
authors.lastname: Hiendleder
authors.forename: G
authors.initials: G
authors.lastname: Erhardt
authors.forename: I
authors.initials: I
authors.lastname: Medjugorac
authors.forename: M
authors.initials: M
authors.lastname: Förster
authors.forename: B
authors.initials: B
authors.lastname: Brenig
authors.forename: F
authors.initials: F
authors.lastname: Reinhardt
authors.forename: R
authors.initials: R
authors.lastname: Reents
authors.forename: I
authors.initials: I
authors.lastname: Russ
authors.forename: G
authors.initials: G
authors.lastname: Averdunk
authors.forename: J
authors.initials: J
authors.lastname: Blümel
authors.forename: E
authors.initials: E
authors.lastname: Kalm
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002452:Cell Count / Q000662:veterinary; D002874:Chromosome Mapping; D004420:Dystocia / Q000235:genetics / Q000662:veterinary; D005260:Female; D005313:Fetal Death / Q000235:genetics / Q000662:veterinary; D005819:Genetic Markers; D016678:Genome; D005838:Genotype; D007774:Lactation / Q000235:genetics*; D008297:Male; D008892:Milk / Q000166:cytology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011270:Pregnancy, Animal / Q000235:genetics*; D040641:Quantitative Trait Loci; D012044:Regression Analysis; D012098:Reproduction / Q000235:genetics; D012730:Sex Chromosomes / Q000235:genetics
chemical_list: D005819:Genetic Markers