title: Identification and expression of Ima, a novel Ral-interacting Drosophila protein.
abstract: We report the identification of Ima, a novel Drosophila MAGUK-like protein, which contains two WW and four PDZ protein interaction domains and interacts with the small GTPase dRal in the yeast two-hybrid system and pull-down assays. The gene is expressed in distinct spatiotemporal patterns throughout embryonic development. Overexpression of Ima interferes with normal Drosophila development, indicating that the gene functions in a tissue specific manner.
authors.affiliation: Abteilung Molekulare Entwicklungsbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, 37077 Göttingen, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Beller
authors.forename: Stephen
authors.initials: S
authors.lastname: Blanke
authors.forename: Doris
authors.initials: D
authors.lastname: Brentrup
authors.forename: Herbert
authors.initials: H
authors.lastname: Jäckle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D001665:Binding Sites; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D008969:Molecular Sequence Data; D009703:Nucleoside-Phosphate Kinase; D009928:Organ Specificity; D020539:Sequence Analysis, Protein; D019076:Transgenes; D020798:Two-Hybrid System Techniques
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D009703:Nucleoside-Phosphate Kinase; C472856:MAGI protein, Drosophila