title: [Treatment with lepirudin in heparin-induced thrombocytopenia. A case report].
abstract: We report the case of a 71 old woman presenting a bilateral massive pulmonary embolism with intraventricular right thrombus complicating heparin induced thrombocytopenia (HIT) persistent after one month of conventional anticoagulant processing. We underline the effectiveness of lepirudin (Refludan) in the curative processing of pulmonary embolism allowing here to avoid a complex surgical thromboembolectomy. We evoke the place of this molecule in the curative therapeutic strategy of HIT with thrombotic phenomena.
authors.affiliation: Département des maladies cardiovasculaires.
authors.forename: M
authors.initials: M
authors.lastname: Nippert
authors.forename: E
authors.initials: E
authors.lastname: de Maistre
authors.forename: M
authors.initials: M
authors.lastname: Rodermann
authors.forename: A C
authors.initials: AC
authors.lastname: Vançon
authors.forename: D
authors.initials: D
authors.lastname: Amrein
authors.forename: B
authors.initials: B
authors.lastname: Brembilla-Perrot
authors.forename: T
authors.initials: T
authors.lastname: Lecompte
authors.forename: F
authors.initials: F
authors.lastname: Zannad
authors.forename: E
authors.initials: E
authors.lastname: Aliot
mesh_terms: D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D011655:Pulmonary Embolism / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; C083544:lepirudin