Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus.
OBJECTIVE
To analyze the frequency of human leukocyte antigens class II-DR in children and adolescents with systemic lupus erythematosus.


METHODS
Fifty-fiveBrazilian systemic lupus erythematosus children and adolescents and 308 healthy individuals were studied. Gender, race, and age of onset of systemic lupus erythematosus were recorded. The human leukocyte antigens typing of class II-DR was carried out by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Data were analyzed statistically using the chi square test with Yates' correction, Fisher's exact test, and Bonferroni's correction.


RESULTS
Human leukocyte antigen-DR 15 was the most frequently detected antigen in this group of children and adolescents, and it also occurred more frequently in the female group, in children with onset of systemic lupus erythematosus between 0 and 9 years and between 10 to 14 years, and in the Black race group, but these associations were not statistically significants.


CONCLUSIONS
In this group of children and adolescents with a high degree of racial admixture, we could not verify a significant association between human leukocyte antigens class II-DR and systemic lupus erythematosus.
Liphaus
Bernadete de L
Bde L
Heart Institute, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
Goldberg
Anna Carla
AC
Kiss
Maria Helena B
MH
Silva
Clovis A A
CA
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015802:HLA-DR2 Antigen / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008297:Male; D017678:Sex Distribution; D044465:White People / Q000235:genetics
D015802:HLA-DR2 Antigen