[Investigation on administration method of carbapenems].
Seventy-two women diagnosed as parametritis were enrolled in this study and examined on the effective administration method of carbapenems, imipenem/cilastatin (IPM/CS), panipenem/betamipron (PAPM/BP) and meropenem (MEPM). The total dosage of each carbapenem was 1.5 g/day, and administration frequency was twice a day (0.75 g x 2) or three times a day (0.5 g x 3). We reviewed the highest body temperature, white blood cell count and CRP value, before treatment and the fourth day after the start of treatment. Three times a day method was statistically superior to twice a day method in the highest body temperature, and CRP value. When we use carbapenem antimicrobial agents, the basis of PK/PD of time above MIC would lead to the increasing clinical effects.
Mikamo
Hiroshige
H
Department of Obstetrics and Gynecology, Gifu University School of Medicine 40, Tsukasa-machi, Gifu City, Gifu 500-8705, Japan.
Ninomiya
Mochiyoshi
M
Tamaya
Teruhiko
T
D000328:Adult; D000368:Aged; D001831:Body Temperature; D002097:C-Reactive Protein; D015780:Carbapenems / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015377:Cilastatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077728:Cilastatin, Imipenem Drug Combination; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007958:Leukocyte Count; D000077731:Meropenem; D008875:Middle Aged; D010249:Parametritis / Q000188:drug therapy* / Q000503:physiopathology; D013845:Thienamycins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015091:beta-Alanine / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000493:pharmacokinetics
D015780:Carbapenems; D004338:Drug Combinations; D013845:Thienamycins; D015091:beta-Alanine; C075316:panipenem-betamipron; D015377:Cilastatin; D015378:Imipenem; D002097:C-Reactive Protein; D000077728:Cilastatin, Imipenem Drug Combination; D000077731:Meropenem