Definitive identification of cysteine and glutathione complexes of bismuth by mass spectrometry: assessing the biochemical fate of bismuth pharmaceutical agents.
Solutions containing BiCl3, bismuth subsalicylate or Bi(NO3)3 with L-cysteine, DL-homocysteine, D-methionine or glutathione have been examined by electrospray mass spectrometry. Prominent peaks are assigned to bismuth complexes of these biomolecules and provide insight towards understanding the bioactivity of bismuth compounds.
Burford
Neil
N
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada. neil.burford@dal.ca
Eelman
Melanie D
MD
Mahony
David E
DE
Morash
Michael
M
D001729:Bismuth / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D004364:Pharmaceutical Preparations; D005978:Glutathione; D003545:Cysteine; D001729:Bismuth