Association analysis for dopamine D3 receptor, dopamine D4 receptor and dopamine transporter genetic polymorphisms and P300 event-related potentials for normal young females.
OBJECTIVE
It has been demonstrated that the P300 components, a positive event-related potential, are heritable and are influenced by dopaminergic activity. We tested the genetic effects of the dopaminergic system in P300 components by association study.


METHODS
In a sample population consisting of 120 normal young Han-Chinese females, we explored the association between the P300 components, and, the genetic polymorphisms including the dopamine D3 receptor (serine-to-glycine polymorphism in exon I), the dopamine D4 receptor (variable number tandem repeat polymorphism in exon III), and the dopamine transporter (variable number tandem repeat polymorphism in promoter region).


RESULTS
No associations were demonstrated between the polymorphisms of these three genes and the P300 components.


CONCLUSIONS
Our negative findings suggest that these genetic polymorphisms do not play a major role in the modulation of P300 event-related potentials.
Tsai
Shih-Jen
SJ
Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan.
Yu
Younger W-Y
YW
Chen
Tai-Jui
TJ
Chen
Ming-Chao
MC
Hong
Chen-Jee
CJ
D000328:Adult; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D050483:Dopamine Plasma Membrane Transport Proteins; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D005091:Exons; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4; D012016:Reference Values; D020080:Tandem Repeat Sequences
C493593:DRD3 protein, human; C493599:DRD4 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4; D004247:DNA