title: Capofungin therapy for Aspergillus lung infection in a boy with chronic granulomatous disease.
abstract: Neutrophils of patients with chronic granulomatous disease (CGD) are profoundly defective in killing microorganisms. As in patients with chemotherapy-induced neutropenia, CGD patients are highly susceptible to life-threatening invasive Aspergillus infections, and conventional antimycotic treatment is not always successful. The new drug, caspofungin, was used to treat Aspergillus lung infection in one child with CGD.
authors.affiliation: Department of Pediatrics, University of Dresden, Germany.
authors.forename: Svea
authors.initials: S
authors.lastname: Sallmann
authors.forename: Antje
authors.initials: A
authors.lastname: Heilmann
authors.forename: Frank
authors.initials: F
authors.lastname: Heinke
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Kerkmann
authors.forename: Markus
authors.initials: M
authors.lastname: Schuppler
authors.forename: Gabriele
authors.initials: G
authors.lastname: Hahn
authors.forename: Manfred
authors.initials: M
authors.lastname: Gahr
authors.forename: Angela
authors.initials: A
authors.lastname: Rösen-Wolff
authors.forename: Joachim
authors.initials: J
authors.lastname: Roesler
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D000077336:Caspofungin; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D054714:Echinocandins; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis*; D006801:Humans; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D010455:Peptides; D010456:Peptides, Cyclic; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D000077336:Caspofungin