title: Evaluation of tumor proliferation using dynamic contrast enhanced-MRI of oral cavity and oropharyngeal squamous cell carcinoma.
abstract: We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochemical staining with the anti-PCNA antibody. The relationship between the dynamic MRI parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with maximum CI and maximum CI gain (P<0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer.
authors.affiliation: Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Konouchi
authors.forename: Jun ichi
authors.initials: Ji
authors.lastname: Asaumi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Yanagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shigehara
authors.forename: Miki
authors.initials: M
authors.lastname: Hisatomi
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Kanji
authors.initials: K
authors.lastname: Kishi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D009959:Oropharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D018809:Proliferating Cell Nuclear Antigen