An evaluation of the suitability of intravenous midazolam as an in vivo marker for hepatic cytochrome P4503A activity.
Rogers
Janyce F
JF
Clinical Pharmacology Research Center and Department of Medicine, Bassett Healthcare, One Atwell Road, Cooperstown, NY 13326-1394, USA.
Rocci
Mario L
ML
Haughey
David B
DB
Bertino
Joseph S
JS
D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008874:Midazolam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008954:Models, Biological
D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System; D008874:Midazolam