The effects of Ginkgo biloba extracts on the memory and motor functions of rats with chronic cerebral insufficiency.
The main goal of the current study was to investigate the effects of two Ginkgo leaf extracts, EGb 761 and an extract of local Ginkgo leaf (LGb), on the memory and motor functions of rats with chronic cerebral insufficiency (produced by bilateral common carotid artery ligation). After the operation, spatial memory and motor functions were tested for over 80 days. Tests included (1) radial-arm maze test for testing spatial memory and locomotor activity and (2) muscle force and hind limbs for escape. The results indicate that both EGb 761 and LGb improved spatial memory from the second week after operation, but only EGb 761 delayed deterioration of motor functions from the fifth week after operation.
Lin
Chou-Ching K
CC
Department of Neurology, National Cheng-Kung University Hospital, 138 Sheng-Li Road, Tainan 701, Taiwan, ROC. CXL45@mail.ncku.edu.tw
Cheng
Wen-Ling
WL
Hsu
Shan-Hui
SH
Chang
Chieh-Ming J
CM
D000818:Animals; D002545:Brain Ischemia / Q000523:psychology*; D002908:Chronic Disease; D020441:Ginkgo biloba; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior / Q000187:drug effects; D000096983:Ginkgo Extract
D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract