title: Evaluation of health-related quality of life using the MOS 36-Item Short-Form Health Status Survey in patients receiving noninvasive positive pressure ventilation.
abstract: OBJECTIVE
  To collect benchmark data on the MOS 36-Item Short-Form Health Status Survey (SF-36) in patients receiving noninvasive positive pressure ventilation and to examine whether health-related quality of life is influenced by the underlying disease or by physical parameters.
  
  
  METHODS
  Multicentric clinical cross-sectional trial in four general wards specialized in noninvasive positive pressure ventilation.
  
  
  METHODS
  226 patients (78 chronic obstructive pulmonary disease, 57 kyphoscoliosis, 20 posttuberculosis sequelae, 17 Duchenne muscular dystrophy, 13 polyneuropathy, 13 myopathy, 6 amyotrophic lateral sclerosis, 12 obesity-hypoventilation syndrome, 4 poliomyelitis sequelae, 3 phrenic nerve lesion, 3 central hypoventilation syndrome) who used noninvasive positive pressure ventilation for home mechanical ventilation.
  
  
  RESULTS
  Health-related quality of life as assessed by the SF-36 was lower than in the general population. Overall the Physical Component Summary (PCS) was significantly lower than the general population norm; the Mental Component Summary (MCS) was also reduced but less markedly. Patients with chronic obstructive pulmonary disease were more impaired in MCS than those with kyphoscoliosis. PCS was significantly associated with age. Gender, lung function, and arterial blood gas values were not significant predictors of health-related quality of life.
  
  
  CONCLUSIONS
  Benchmark SF-36 data in patients receiving noninvasive positive pressure ventilation are given. Although physical health is significantly impaired in these patients, this does not necessarily lead to mental limitation, and mental health is influenced by the underlying disease, but not by physical parameters.
authors.affiliation: Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106, Freiburg, Germany. windisch@med1.ukl.uni-freiburg.de
authors.forename: Wolfram
authors.initials: W
authors.lastname: Windisch
authors.forename: Klaus
authors.initials: K
authors.lastname: Freidel
authors.forename: Bernd
authors.initials: B
authors.lastname: Schucher
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Baumann
authors.forename: Matthias
authors.initials: M
authors.lastname: Wiebel
authors.forename: Heinrich
authors.initials: H
authors.lastname: Matthys
authors.forename: Franz
authors.initials: F
authors.lastname: Petermann
mesh_terms: D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D006305:Health Status Indicators; D006699:Home Care Services; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life; D011795:Surveys and Questionnaires