title: Clinical and occupational outcomes in health care workers with natural rubber latex allergy.
abstract: BACKGROUND
  There is limited information pertaining to clinical outcomes and economic consequences of natural rubber latex (NRL) allergy in health care workers (HCWs).
  
  
  OBJECTIVE
  To evaluate retrospectively health and economic outcomes in HCWs identified with NRL allergy and percutaneous reactivity to NRL.
  
  
  METHODS
  Sixty-seven HCWs with NRL allergy, confirmed by percutaneous reactivity to non-ammoniated latex (NAL) extract, were administered a detailed questionnaire to evaluate clinical and economic outcomes of active work and environmental interventions subsequent to recognition of work-related symptoms associated with NRL gloves.
  
  
  RESULTS
  Diagnoses based on predetermined case definitions associated with direct or indirect exposure to NRL gloves included contact urticaria in 67 (100%); work-related rhinitis in 23; work-related asthma symptoms in 25; and work-related anaphylaxis in 4 workers. Work related symptoms reportedly resolved in 44 of 49 (90%) of NAL skin test-positive workers who had reported skin, respiratory, and/or systematic symptoms and remained in their current work area and who switched to non-NRL gloves. Four of 24 (17%) workers with work-related asthma symptoms were compelled to change employment to NRL-safe workplaces, resulting in a mean 24% reduction in annual income.
  
  
  CONCLUSIONS
  Clinical outcomes in this group of HCWs with NRL allergy were favorable after institution of interventions but incurred deleterious consequences in a minority of workers.
authors.affiliation: University of Cincinnati College of Medicine, Division of Immunology, Department of Internal Medicine, Cincinnati, Ohio 45267-0563, USA. bernstdd@email.uc.edu
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
authors.forename: Ravi
authors.initials: R
authors.lastname: Karnani
authors.forename: Ray E
authors.initials: RE
authors.lastname: Biagini
authors.forename: Cheryl K
authors.initials: CK
authors.lastname: Bernstein
authors.forename: Karen
authors.initials: K
authors.lastname: Murphy
authors.forename: Brian
authors.initials: B
authors.lastname: Berendts
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Bernstein
authors.forename: Leonard
authors.initials: L
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D000368:Aged; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000191:economics / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D017575:Gloves, Protective / Q000009:adverse effects*; D006282:Health Personnel; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000191:economics / Q000503:physiopathology / Q000517:prevention & control; D020315:Latex Hypersensitivity / Q000175:diagnosis / Q000191:economics / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000191:economics / Q000503:physiopathology / Q000517:prevention & control; D016273:Occupational Exposure; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012882:Skin Tests; D011795:Surveys and Questionnaires