title: Is isolated palatal anomaly an indication to screen for 22q11 region deletion?
abstract: OBJECTIVE
  Velocardiofacial syndrome (VCFS) is the most common multiple anomaly disorder associated with palatal clefting. Cytogenetic hemizygous deletion of 22q11 region is found in 80% of patients. The frequency of 22q11 deletion in patients presenting with isolated palatal anomalies has not been fully assessed. Our objective was to determine the frequency of the deletion in patients with isolated palatal anomalies.
  
  
  METHODS
  Patients were referred because of velopharyngeal insufficiency because of isolated congenital palatal anomalies. Diagnosis of palatal anomalies was confirmed by videonasopharyngoscopy, multiview videofluoroscopy and cephalometry. Other clinical findings suggestive of VCFS were sought, and subjects with these characteristics were excluded from the study. Peripheral blood samples from all patients were analyzed cytogenetically utilizing fluorescent in situ hybridization for the 22q11 region.
  
  
  RESULTS
  Thirty-eight patients aged 3 to 31 years were included in the study. Nine had cleft palate, 7 cleft lip and palate, 10 overt and 11 occult submucous cleft palate, and 1 had a deep nasopharynx. No deletion of 22q11 region was detected in any of the evaluated patients.
  
  
  CONCLUSIONS
  A routine screening for the 22q11 deletion in older children and adults presenting with an isolated palatal anomaly may not be required. Because other signs related to VCFS such as facial dysmorphism and behavioral or psychiatric disorders may evolve at an older age, young patients should be followed up and reevaluated for additional relevant symptoms that may lead to deletion evaluation. In light of the fact that the current literature is inconsistent, the relative small size of this study and the significant consequences of missed 22q11.2 deletion, more information is needed before definitive recommendations can be made.
authors.affiliation: Genetic Institute, Assaf Harofeh Medical Center, Zerifin, Israel. oreish@post.tau.ac.il
authors.forename: Orit
authors.initials: O
authors.lastname: Reish
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Finkelstein
authors.forename: Ronit
authors.initials: R
authors.lastname: Mesterman
authors.forename: Ariela
authors.initials: A
authors.lastname: Nachmani
authors.forename: Baruch
authors.initials: B
authors.lastname: Wolach
authors.forename: Moshe
authors.initials: M
authors.lastname: Fejgin
authors.forename: Aliza
authors.initials: A
authors.lastname: Amiel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D005820:Genetic Testing / Q000706:statistics & numerical data; D006330:Heart Defects, Congenital / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D013577:Syndrome