Expression of gamma-adducin is associated with regions of morphogenetic cell movement in the chick embryo.
The adducin family of cytoskeletal proteins are known to mediate actin driven cell movements. Here we describe the cloning and expression pattern of a gene encoding gamma-adducin in the chick embryo. Expression of this gene is strikingly restricted to the epithelial cell layer (with a few exceptions including emerging notochord and lateral mesoderm). Gamma-adducin is detected at particularly high levels in cell populations undergoing important morphogenetic movements, such as epiblast approaching the primitive streak, regressing spinal cord primordia and closing neural tube.
Akai
Jun
J
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Storey
Kate
K
D000595:Amino Acid Sequence; D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D002642:Chick Embryo; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D009928:Organ Specificity; D016415:Sequence Alignment; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D000099291:Adducins