title: Intrahippocampal histamine delays arousal from hibernation.
abstract: Hibernation is a state of extremely reduced physiological functions and a deep depression of CNS activity, which is thought to be under hippocampal control. Our previous findings indicate increased histamine turnover during hibernation in several brain regions, including the hippocampus. In this study we showed that histamine infused into the hippocampus significantly delayed arousal from hibernation. These findings indicate that histamine may contribute to maintaining the hibernating state, suggesting a novel role for histamine in controlling arousal state.
authors.affiliation: Department of Biology, Abo Akademi University, Artillerigatan 6, BioCity, 20520, Abo/Turku, Finland. tsallmen@abo.fi
authors.forename: Tina
authors.initials: T
authors.lastname: Sallmen
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Lozada
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Beckman
authors.forename: Pertti
authors.initials: P
authors.lastname: Panula
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006605:Hibernation / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D012589:Sciuridae / Q000502:physiology; D013997:Time Factors
chemical_list: D006632:Histamine