Leukemic dissemination within a glioblastoma in a patient with chronic lymphoid leukemia.
Metastasis from an extracranial tumor to a primary central nervous system tumor is a rare event, and most reported cases concern metastases to meningiomas. The authors describe the first case of leukemic cell dissemination within a glioblastoma. The patient likely presented a genetic predisposition to multiple neoplasms, and the unusual localization of leukemic cells might be partly related to the characteristic microvascular proliferation in glioblastoma.
Bouillot
S
S
Neuropathology Department, Pellegrin Hospital, Bordeaux, France. sandrine.bouillot@chu-bordeaux.fr
Vignes
J R
JR
Guerin
J
J
Dubus
P
P
Vital
A
A
D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D017809:Fatal Outcome; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D017254:Leukemic Infiltration / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed