Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives.
In this study, alpha-diazo-beta-oxoaldehyde compounds were condensed with different amines to yield 4-acyl-1H-1,2,3-triazole derivatives. The 1,2,3-triazole compounds were investigated for their inhibition activities against tuberculosis.
Dabak
Kadir
K
Department of Chemistry, Faculty of Sciences, Istanbul Technical University, 80626 Maslak, Istanbul, Turkey. kadird@exzacibasi.com.tr
Sezer
Ozkan
O
Akar
Ahmet
A
Anaç
Olcay
O
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D013830:Thiadiazoles