Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 beta-lactamase production.
Two multidrug-resistant Salmonella enterica serovar Wien strains (SW468 and SW1107) were isolated in 2001 in Tunis. Both strains produced the beta-lactamases TEM-1, SHV-2a, and CMY-4, whereas strain SW1107 also produced the beta-lactamase CTX-M-3. The imipenem-resistant strain (SW468) was totally devoid of the OmpF-immunorelated porin. Imipenem resistance was shown as being related to porin loss and CMY-4 beta-lactamase production.
Armand-Lefèvre
L
L
Hôpital Ambroise Paré AP-HP, Service de Microbiologie-Hygiène, Boulogne, France.
Leflon-Guibout
V
V
Bredin
J
J
Barguellil
F
F
Amor
A
A
Pagès
J M
JM
Nicolas-Chanoine
M-H
MH
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000737:chemistry; D017931:DNA Primers; D024881:Drug Resistance, Bacterial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007231:Infant, Newborn; D010957:Plasmids / Q000235:genetics; D018272:Porins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics; D013845:Thienamycins / Q000494:pharmacology*; D014169:Transformation, Bacterial; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D017931:DNA Primers; C109237:OmpF protein; D018272:Porins; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; C476341:beta-lactamase CMY-4, Salmonella enterica