title: Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22.
abstract: A Swiss frontotemporal dementia (FTD) kindred with extrapyramidal-like features and without motor neuron disease shows a brain pathology with ubiquitin-positive but tau-negative inclusions. Tau and neurofilament modifications are now studied here in three recently deceased family members. No major and specific decrease of tau was observed as described by others in, e.g., sporadic cases of FTD with absence of tau-positive inclusions. However, a slight decrease of tau, neurofilament, and synaptic proteins, resulting from frontal atrophy was detected. In parallel, polymorphic markers on chromosome 17q21-22, the centromeric region of chromosome 3 and chromosome 9, were tested. Haplotype analysis showed several recombination events for chromosomes 3 and 17, but patients shared a haplotype on chromosome 9q21-22. However as one of the patients exhibited Alzheimer and vascular dementia pathology with uncertain concomitant FTD, this locus is questionable. Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family.
authors.affiliation: Department of Psychiatry, University of Geneva School of Medicine, 1225 Geneva, Switzerland.
authors.forename: Armand
authors.initials: A
authors.lastname: Savioz
authors.forename: Beat M
authors.initials: BM
authors.lastname: Riederer
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rizzu
authors.forename: Markus
authors.initials: M
authors.lastname: Tolnay
authors.forename: Enikö
authors.initials: E
authors.lastname: Kövari
authors.forename: Alphonse
authors.initials: A
authors.lastname: Probst
authors.forename: I rène M
authors.initials: Ir
authors.lastname: Riederer
authors.forename: Constantin
authors.initials: C
authors.lastname: Bouras
authors.forename: Geneviève
authors.initials: G
authors.lastname: Leuba
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D003704:Dementia / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016900:Neurofilament Proteins / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D010375:Pedigree; D013557:Switzerland; D050825:Synaptosomal-Associated Protein 25; D016875:tau Proteins / Q000172:deficiency* / Q000235:genetics
chemical_list: D005819:Genetic Markers; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25; C044882:neurofilament protein L; D016875:tau Proteins