Employing the simple monosilylcopper reagent, Li[PhMe2SiCuI], in 1,4-addition reactions.
Conjugate addition reactions using the simple Li[PhMe2SiCuI] reagent to a variety of alpha,beta-unsaturated carbonyl compounds is described; dimethyl sulfide from the purification of CuI plays a key role for very high yields as well as high stereoselectivities in the formation of beta-silyl carbonyl compounds.
Dambacher
Jesse
J
Department of Chemistry, San Diego State University, San Diego, CA 92182-1030, USA.
Bergdahl
Mikael
M