Chirality transfer during alkylation of chiral amides.
Chiral amides derived from O-methyl mandelic acid and achiral amines underwent enantioselective alpha-methylation on treatment with LTMP followed by addition of methyl iodide; chirality transfer from an undeprotonated chiral amide into an achiral enolate in a mixed aggregate is supposed to be responsible for the asymmetric induction.
Kawabata
Takeo
T
Institute for Chemical Research, Kyoto University, Uji, Kyoto-61-0011, Japan. kawabata@scl.kyoto-u.ac.jp
Oztürk
Orhan
O
Chen
Jianyong
J
Fuji
Kaoru
K