[Pharmacokinetic and pharmacodynamic effects of isradipine in patients with arterial hypertension].
It was established that a regular administration of isradipine is accompanied by an increase in the mean values of Cmax (by 21.7%) and AUC (by 21.8%), which leads to extension of the pharmacodynamics effects without cumulation (the values of Clt, T1/2, and Tmax remain unchanged). The maximum hemodynamic effect of isradipine upon a single administration in a single dose of 5 mg coincides with the time or reaching the maximum drug concentration in the blood (Tmax). There is a reliable correlation between the hypotensive effect, the peripheral vascular resistance, and the concentration of isradipine.
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Clinical Pharmacology Department, Sechenov Medical Academy, ul. Bol'shaya Pirogovskaya 13, Moscow, 119881 Russia.
Alekhin
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D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D017275:Isradipine / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D002121:Calcium Channel Blockers; D017275:Isradipine