Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea pig.
OBJECTIVE
To determine the effect of interleukin-1 receptor antagonist (IL-1ra) on allergic rhinitis.


METHODS
Allergic rhinitis was induced by toluene-2,4-diisocyanate (TDI). At the end of the treatment, the pathological changes in the nasal mucosa were observed. The concentrations of histamine in the nasal mucosa and IgE in the blood were determined as well.


RESULTS
Symptoms of allergic rhinitis were remarkably relieved after IL-1ra treatment. Hematoxylin and eosin staining demonstrated that less edema was found in the nasal mucosa and small vessel was normal after IL-1ra application, but edema,vasodilation, and inflammatory cell infiltration were discovered in the model group. The concentrations of histamine in the nasal mucosa and IgE in the blood were less than those in the control group.


CONCLUSIONS
IL-1ra im administration selectively and non-traumatically alleviated nasal congestion, rhinorrhea, and sneezing.
Zhang
Hong-Quan
HQ
The Medical and Pharmaceutical Academy of Yangzhou Univerity, 225001, China.
Sun
Yun
Y
Xu
Feng
F
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012795:Sialoglycoproteins / Q000627:therapeutic use*; D014051:Toluene 2,4-Diisocyanate
D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E; D006632:Histamine