Infection of growing swine with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae--effects on growth, serum metabolites, and insulin-like growth factor-I.
This study evaluated the influence of concomitant infections with porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae on growth performance, serum metabolite concentrations, and serum insulin-like growth factor-I (IGF-I) in growing pigs. Twenty-two barrows (10 weeks of age) were treated with either an intranasal administration of PRRSV and an intratracheal infusion of M. hyopneumoniae (treatment; n = 8) or a sham inoculation with medium (sham; n = 8), or were not treated (control; n = 6). The sham pigs were matched by body weight and pair-wise fed with treatment pigs. Pigs were weighed on the day of inoculation (day 0) and at 4 weeks postinoculation (day 28). Blood samples were collected prior to inoculation and at weekly intervals for 4 weeks. Pigs in the treatment group exhibited clinical signs consistent with PRRSV infection and M. hyopneumoniae pneumonia. Diagnostic procedures confirmed that treatment pigs were inoculated with PRRSV and M. hyopneumoniae and that sham and control pigs remained free of both pathogens. Average daily gain and feed conversion did not differ among the 3 groups. The IGF-I levels differed (P < 0.05) between control and treatment pigs, even after feed intake returned to similar levels among groups. At day 7, IGF-I concentrations were greater in sham pigs compared with treatment pigs, despite similar feed intake. Sham inoculation and decreased feed intake in sham pigs did not alter serum IGF-I concentrations. Evidently, IGF-I status of pigs affected with disease is influenced by nutritional and nonnutritional factors during the disease process.
Roberts
N Elizabeth
NE
Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
Almond
Glen W
GW
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D004435:Eating; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D045729:Pneumonia of Swine, Mycoplasmal / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000662:veterinary*; D019318:Porcine Reproductive and Respiratory Syndrome / Q000097:blood / Q000503:physiopathology*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
D001786:Blood Glucose; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol