[Locomotor activity and expression of c-Fos protein in the brain of C57BL and Balb/c mice: effects of D-amphetamine and sydnocarb].
Effects of the psychostimulants D-amphetamine and sydnocarb on the locomotor activity and c-Fos protein expression in the brain of C57BL and BALB/c mice was studied. The drugs significantly increase the locomotor activity and the level of c-Fos protein in the brain structures of both lines. The effect of D-amphetamine with respect to the locomotor activity was more pronounced in C57BL mice, which correlates with a higher level of the c-Fos expression in the secondary motor cortex. At the same time syndocarb more significantly than D-amphetamine induces expression of the c-Fos protein in the nucleus accumbens core of C57BL mice. Injection of an 0.85% NaCl solution led to a moderate increase in the locomotor activity in the mice of both lines, while the c-Fos expression in the secondary motor cortex and septum was more pronounced in C57BL than in BALB/c mice.
Novoselov
I A
IA
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Cherepov
A B
AB
Raevskiĭ
K S
KS
Anokhin
K V
KV
D000818:Animals; D001921:Brain / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013558:Sydnones / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D016760:Proto-Oncogene Proteins c-fos; D013558:Sydnones; D003913:Dextroamphetamine; C009257:sidnocarb