Target cells in vaginal HIV transmission.
Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.
Miller
Christopher J
CJ
Department of Veterinary Pathology, Microbiology and Immunology, Center for Comparative Medicine, School of Veterinary Medicine, California National Primate Research Center, University of California-Davis, Davis, CA 95616, USA. cjmiller@ucdavis.edu
Shattock
Robin J
RJ
D000818:Animals; D004848:Epithelium / Q000033:anatomy & histology / Q000276:immunology; D005260:Female; D006678:HIV / Q000472:pathogenicity; D015658:HIV Infections / Q000378:metabolism / Q000635:transmission*; D006801:Humans; D007155:Immunologic Factors; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity; D014621:Vagina / Q000166:cytology / Q000276:immunology / Q000821:virology*
D007155:Immunologic Factors