A new bioactive steroidal saponin from Sansevieria cylindrica.
A new steroidal saponin was isolated from the leaves of Sansevieria cylindrica. Its structure was established as (3beta,12beta,15alpha,25S)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl 12-O- (6-deoxy-alpha-L-mannopyranosyl)-15-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside. The structural identification was performed using detailed analyses of (1)H and (13)C NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR, HMBC and HMQC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.
Da Silva Antunes
Alexandra
A
Núcleo de Pesquisas de Produtos Naturiais, Laboratório de Química de Plantas Medicinais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, CEP 21944-970 Rio de Janeiro, RJ, Brasil.
Da Silva
Bernadete Pereira
BP
Parente
José Paz
JP
Valente
Ana Paula
AP
D019342:Acetic Acid; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D031444:Sansevieria; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013256:Steroids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D019342:Acetic Acid