Pain on injection of propofol: the effect of granisetron pretreatment.
OBJECTIVE
To assess the effect of granisetron pretreatment in alleviating propofol injection pain.


METHODS
A randomized, controlled, double-blind study, using venous retention with a tourniquet.


METHODS
One hundred fifty adult patients were randomly assigned to one of three groups: group 1 (who received 5 mL of 0.9% saline pretreatment), group 2 (who received 5 mL lidocaine [40 mg in 0.9% saline] pretreatment), and group 3 (who received 5 mL granisetron [2 mg in 0.9% saline] pretreatment). Injections were given in the largest vein on the dorsum of the hand. After 2 minutes, the tourniquet was released and one fourth of the total calculated dose of propofol (2.5 mg/kg body weight) was administered and pain assessment was made.


RESULTS
Lidocaine and granisetron significantly reduced the incidence and severity of propofol injection pain more than placebo (P < 0.001). The efficacy of granisetron in alleviating the pain on injection of propofol was no different from lidocaine.


CONCLUSIONS
Granisetron pretreatment may be used to reduce the incidence of pain on injection of propofol, an advantage added to the useful prevention of postoperative nausea and vomiting.
Dubey
Prakash K
PK
Department of Anesthesiology, Indira Gandhi Institute of Medical Sciences, Patna 800 013, India.
Prasad
Sureshwar S
SS
D000328:Adult; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D017829:Granisetron / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010146:Pain / Q000145:classification / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement / Q000379:methods; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012702:Serotonin Antagonists / Q000008:administration & dosage; D016896:Treatment Outcome
D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D017829:Granisetron; D015742:Propofol; D012702:Serotonin Antagonists