Asymmetric cell division: Miranda chauffeured by Jaguar?
Drosophila neuroblasts divide to produce daughters of distinct fate by asymmetrically localizing cell fate determinants and segregating them preferentially to one daughter. An intact F-actin cytoskeleton was known to be required, and now a myosin VI (Jaguar) has been shown to be necessary for basal targeting of cell fate determinants in neuroblasts.
Tuxworth
Richard
R
MRC Centre for Developmental Neurobiology, New Hunt's House, Guy's Hospital Campus, King's College London, SE1 1UL, London, United Kingdom
Chia
William
W
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000166:cytology / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D017344:Genes, Insect; D018995:Myosin Heavy Chains / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C107613:Mira protein, Drosophila; C089785:myosin VI; D018995:Myosin Heavy Chains