title: Conversion to multiple sclerosis after a clinically isolated syndrome of the brainstem: cranial magnetic resonance imaging, cerebrospinal fluid and neurophysiological findings.
abstract: OBJECTIVE
  Conversion to multiple sclerosis (MS) after optic neuritis and myelitis has been thoroughly studied; however, limited data are available regarding conversion to MS after a clinically isolated syndrome of the brainstem (CISB). The aim of this study was to investigate conversion to MS in patients with CISB.
  
  
  METHODS
  Fifty-one patients with CISB were prospectively studied. Cranial magnetic resonance imaging (MRI), determination of oligoclonal bands (OBs) in the cerebrospinal fluid (CSF) and evoked potentials (EPs) were performed. Based on conversion to MS at follow-up, the sensitivity, specificity, accuracy and positive and negative predictive values of these tests were calculated.
  
  
  RESULTS
  Clinically definite MS developed in 18 (35%) patients after a mean follow-up of 37 months. Paty's MRI criteria showed a sensitivity of 89%, a specificity of 52% and an accuracy of 65%; Fazekas' criteria showed a sensitivity of 89%, a specificity of 48% and an accuracy of 63%; Barkhof's criteria showed a sensitivity of 78%, a specificity of 61% and an accuracy of 67%. The presence of OBs in the CSF showed a sensitivity of 100%, a specificity of 42% and an accuracy of 63%. No differences for neurophysiological parameters were found between patients who did and those who did not convert to MS.
  
  
  CONCLUSIONS
  Fulfilling Paty's, Fazekas' or Barkhof's MRI criteria and the presence of OBs in the CSF are associated with a higher risk of conversion to MS in patients with CISB. Determination of OBs in the CSF has the greatest sensitivity of all tests. Barkhof's MRI criteria have greater specificity (although less than previously published for mixed cohorts of clinically isolated syndromes) in predicting conversion to MS for CISB than either Paty's or Fazekas' criteria.
authors.affiliation: Unitat de Neuroimmunologia Clínica, Hospital Vall d'Hebron, Escola d'Infermeria, Barcelona, España. jsastre@hg.vhebron.es
authors.forename: J
authors.initials: J
authors.lastname: Sastre-Garriga
authors.forename: M
authors.initials: M
authors.lastname: Tintoré
authors.forename: A
authors.initials: A
authors.lastname: Rovira
authors.forename: E
authors.initials: E
authors.lastname: Grivé
authors.forename: I
authors.initials: I
authors.lastname: Pericot
authors.forename: M
authors.initials: M
authors.lastname: Comabella
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: X
authors.initials: X
authors.lastname: Montalban
mesh_terms: D000293:Adolescent; D000328:Adult; D001933:Brain Stem / Q000473:pathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity