title: Recurrence after treatment by loop electrosurgical excision procedure (LEEP) of high-grade cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To evaluate the recurrence rate of high-grade CIN treated by loop electrosurgical excision procedure (LEEP) and the optimal follow-up schedule.
  
  
  METHODS
  622 cases of CIN2/3 consecutively treated by LEEP in the Florence screening program, with 66.5 months average follow-up (range, 6-195 months), were evaluated. Recurrence was defined as histological evidence of high-grade CIN.
  
  
  RESULTS
  The average recurrence rate was 9.1% (52 cases). Recurrence was significantly associated to increasing age (chi2 = 12.73, df = 3, P < 001), CIN grade (10.5 vs 6.1%, chi2 = 3.37, df = 1, P = 0.067), and time interval, with the risk of developing a recurrence highest in the first year (7.4%, 95% confidence interval, 5.3-9.5%.), and rare beyond the third year. Multivariate analysis confirmed a significant independent association of age (particularly over age 40) and CIN grade to the risk of recurrence.
  
  
  CONCLUSIONS
  LEEP is an effective procedure for the treatment of high-grade CIN. Most recurrences after LEEP occur in the first 3 years, and non-recurrent cases at that date may stop intensive follow-up and return to current cytological screening every 3 years.
authors.affiliation: Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Cecchini
authors.forename: Carmen Beatriz
authors.initials: CB
authors.lastname: Visioli
authors.forename: Marco
authors.initials: M
authors.lastname: Zappa
authors.forename: Stefano
authors.initials: S
authors.lastname: Ciatto
mesh_terms: D000328:Adult; D003127:Colposcopy; D004598:Electrosurgery / Q000295:instrumentation* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery*