title: Effects of breed (Angus vs Simmental) and copper and zinc source on mineral status of steers fed high dietary iron.
abstract: Forty-four Angus (n = 24) and Simmental (n = 20) steers, averaging 301 kg initially, were used to determine the effects of breed and Cu and Zn source (SO4 or proteinate (Prot) form) on Cu and Zn status of steers fed high dietary iron (Fe). Steers were stratified by weight within breed and randomly assigned to treatments. Treatments consisted of: 1) CuSO4 + ZnSO4 ,2) CuSO4 + ZnProt, 3) CuProt + ZnSO4, and 4) CuProt + ZnProt. Copper and Zn sources were added to provide 5 mg Cu and 25 mg supplemental Zn/kg DM. All steers were individually fed a corn silage-based diet supplemented with 1,000 mg Fe (from FeSO4)/kg DM. Liver biopsy samples were obtained at the beginning and end of the 149-d study. Serum samples were collected initially and at 28-d intervals for determination of ceruloplasmin activity and Zn and Cu concentrations. Copper and Zn source did not affect performance, serum or liver Cu and Zn concentrations, or ceruloplasmin activity. Copper status decreased (P < 0.01) in all steers with time, and increasing the level of supplemental Cu from 5 to 10 mg/kg DM on d 84 did not prevent further drops in serum Cu and ceruloplasmin. Simmental steers had lower (P < 0.05) serum and liver Cu concentrations, and serum ceruloplasmin activity throughout the study. These results indicate that neither CuSO4 nor CuProt were effective at the supplemental concentrations evaluated in alleviating the adverse effect of high Fe on Cu status. Simmental steers had lower Cu status than Angus, suggesting a higher Cu requirement.
authors.affiliation: Department of Animal Science and Interdepartmental Nutrition Program, North Carolina State University, Raleigh 27695-7621, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Mullis
authors.forename: J W
authors.initials: JW
authors.lastname: Spears
authors.forename: B L
authors.initials: BL
authors.lastname: McCraw
mesh_terms: D000818:Animals; D001682:Biological Availability; D001947:Breeding; D002417:Cattle / Q000235:genetics* / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D019327:Copper Sulfate / Q000008:administration & dosage; D019266:Iron, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D009751:Nutritional Requirements; D009752:Nutritional Status; D011897:Random Allocation; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D019287:Zinc Sulfate / Q000008:administration & dosage
chemical_list: D019266:Iron, Dietary; D019287:Zinc Sulfate; D003300:Copper; D002570:Ceruloplasmin; D015032:Zinc; D019327:Copper Sulfate