Familial and sporadic Parkinson's disease usually display the same clinical features.
We examined the clinical features of familial (n = 26) and sporadic (n = 52) Parkinson's disease (PD) in patients presenting over the age of 40 years. Familial PD cases were tested for alpha-synuclein or parkin mutations as appropriate. No mutations were found in any of the families investigated. We found no between-group differences in the age at onset of PD, the pattern or severity of parkinsonian features, the dose of antiparkinsonian medications or treatment related complications. Cases of familial and sporadic PD in our cohort of patients display similar clinical features. This may suggest similar etiologies for both familial and sporadic PD.
Carr
J
J
Pacific Parkinson's Research Centre, Vancouver Hospital, University of British Columbia, Room M36, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5.
de la Fuente-Fernández
R
R
Schulzer
M
M
Mak
E
E
Calne
S M
SM
Calne
D B
DB
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000209:etiology; D002524:Cerebellar Ataxia / Q000209:etiology / Q000503:physiopathology; D002819:Chorea / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D016208:Databases, Factual; D003704:Dementia / Q000209:etiology; D018450:Disease Progression; D004421:Dystonia / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008025:Ligases / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D010243:Paralysis / Q000209:etiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology*; D051843:Synucleins; D014202:Tremor / Q000209:etiology / Q000503:physiopathology; D044767:Ubiquitin-Protein Ligases; D051844:alpha-Synuclein
D000978:Antiparkinson Agents; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases