title: Use of thermokeratoplasty for treatment of ulcerative keratitis and bullous keratopathy secondary to corneal endothelial disease in dogs: 13 cases (1994-2001).
abstract: OBJECTIVE
  To evaluate the outcome of thermokeratoplasty for treatment of ulcerative keratitis and bullous keratopathy secondary to corneal endothelial disease in dogs.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  13 dogs.
  
  
  METHODS
  Medical records from 1994 to 2001 for dogs evaluated because of ulcerative keratitis and bullous keratopathy and treated with thermokeratoplasty were reviewed.
  
  
  RESULTS
  There were 7 spayed females, 5 castrated males, and 1 sexually intact male, ranging from 6 to 16 years of age. Ten dogs had endothelial degeneration, and 3 dogs had breed-related endothelial dystrophy. All dogs had bullous keratopathy, characterized by microbullae formation that was detected via biomicroscopy. Recurrent or nonhealing corneal ulcers were detected unilaterally in 5 dogs and bilaterally in 8 dogs. Mean +/- SD duration from thermokeratoplasty until ulcerations were healed for all dogs was 2.2 +/- 1.1 weeks. All dogs that underwent thermokeratoplasty for nonhealing corneal ulceration secondary to endothelial disease and corneal edema had epithelial wound healing and resolution of corneal ulceration. Mean duration of treatment (ie, topical treatment required until resolution of ulceration) was significantly less after thermokeratoplasty than duration of treatment (with multiple treatments) prior to referral.
  
  
  CONCLUSIONS
  It may be necessary to perform thermokeratoplasty of the entire cornea to prevent recurrence of ulcerations in areas that have not been treated with thermokeratoplasty.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
authors.forename: Tammy Miller
authors.initials: TM
authors.lastname: Michau
authors.forename: Brian C
authors.initials: BC
authors.lastname: Gilger
authors.forename: Federica
authors.initials: F
authors.lastname: Maggio
authors.forename: Michael G
authors.initials: MG
authors.lastname: Davidson
mesh_terms: D000818:Animals; D003317:Corneal Dystrophies, Hereditary / Q000601:surgery / Q000662:veterinary; D015715:Corneal Edema / Q000601:surgery / Q000662:veterinary; D016039:Corneal Transplantation / Q000379:methods / Q000662:veterinary*; D003320:Corneal Ulcer / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D008297:Male; D011183:Postoperative Complications / Q000662:veterinary; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014945:Wound Healing