title: Modeling of prebiotic catalysis with adenylated polymeric templates: crystal structure studies and kinetic characterization of template-assisted phosphate ester hydrolysis.
abstract: We have synthesized and characterized novel, copper-metalated, polymeric templates that contain adenine nucleobases. These promote hydrolysis of non-natural and natural phosphate ester substrates in a highly efficient and catalytic fashion. The crystal structure of the cooper-containing adenylated monomer reveals the formation of a polymeric array, through coordination to both N1 and N7 atoms. Possible implications of these studies for prebiotic catalysis, involving synergism between adenine and copper ions, are also discussed.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016, UP, India.
authors.forename: S G
authors.initials: SG
authors.lastname: Srivatsan
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
mesh_terms: D000225:Adenine / Q000737:chemistry*; D000227:Adenine Nucleotides / Q000378:metabolism; D001704:Biopolymers / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003300:Copper / Q000378:metabolism; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D013698:Templates, Genetic; D014638:Vanadates / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D001704:Biopolymers; D004952:Esters; D014638:Vanadates; C010565:2',3'-cyclic AMP; D003300:Copper; D000225:Adenine