Recurrence of lymphangioleiomyomatosis after single lung transplantation: new insights into pathogenesis.
Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of childbearing age. The present study describes a case of recurrent LAM after single lung transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry, and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions originated from the recipient. The data strongly support that metastatic spread of LAM cells or migration of progenitor cells plays an important role in the pathogenesis of LAM.
Bittmann
Iris
I
Institute of Pathology and Institute of Forensic Medicine, Ludwig-Maximilians University, Munich, Germany.
Rolf
Burkhard
B
Amann
Gudrun
G
Löhrs
Udo
U
D000328:Adult; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects*; D018192:Lymphangioleiomyomatosis / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D018598:Minisatellite Repeats / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction
D004273:DNA, Neoplasm