First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase.
The anaphase-promoting complex or cyclosome (APC/C) is a cell-cycle-regulated ubiquitin-protein ligase that has been extensively studied in both fungal and animal cells. Many APC/C protein targets have been identified, and their sequential degradation during the cell cycle is essential for chromatid separation and mitotic exit. APC/C-dependent ubiquitylation of proteins not involved in cell-cycle progression has also been documented in animal cells. By contrast, the plant APC/C's structure and functions remained unexplored until recently. Here, we discuss recent developments in this field and explore the Arabidopsis genome sequence to identify plant APC/C components. Details of the APC/C ubiquitylation pathway in Arabidopsis are also available on a website that will be regularly updated.
Capron
Arnaud
A
Institut de Biologie Moléculaire des Plantes du CNRS, 12, rue du Général Zimmer, 67084 Strasbourg Cédex, France.
Okrész
László
L
Genschik
Pascal
P
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D017360:Arabidopsis / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D008025:Ligases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity; D025801:Ubiquitin / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases
D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases; D008025:Ligases