title: [Enatiomeric separation of beta-blocking agents and analogs]
abstract: OBJECTIVE: To evaluate enantiomeric separation methods for beta-blocking agents and analogs. METHODS: Enantiomeric separation of racemates of 11 beta-blocking agents and their analogs was performed using chiral stationary phases and 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate (GITC). RESULTS: These beta -blocker racemates were separated into enantiomers in one or several chormatographic states such as propranolol, bisoprolol, metoprolol, celiprolol, carvedilol, sotalol, propafenone, ephedrine, and zomitriptan. Temperature had a significant effect on the resolution of the drugs when using chiralcel OD. Lower temperatures were associated with higher resolutions. CONCLUSION: When separating beta-blocking agents and their analogs, Chiralcel OD, Chiralpak AD, Chiral stationary phases and GITC chiral derivative reagents have complementary functions.
authors.affiliation: College of Pharmacy, Zhejiang University, Hangzhou 310031, China.
authors.forename: Lu-Shan
authors.initials: LS
authors.lastname: Yu
authors.forename: Tong-Wei
authors.initials: TW
authors.lastname: Yao
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Su
authors.initials: S
authors.lastname: Zeng