Fibrous dysplasia in the maxilla: possible mechanism of bone remodeling by calcitonin treatment.
The long-term follow-up case of monostotic fibrous dysplasia of the maxilla in a 10-year-old girl is described with her endocrinologic data and therapeutic consequence of calcitonin administration in association with surgical interventions. The fibrous dysplasia tends to become more quiescent or static after skeletal growth ceases, but the causative has been still unknown to date. In this case reported changes of calciotropic hormones in the serum were well corresponding to the ceasing of the tumor growth at the puberty and reflected to the calcitonin administration. Although calcitonin has been applied to the fibrous dysplasia associated with McCune Albright syndrome, no histologic changes have been described after the calcitonin treatment. This report might be the first description of bone remodeling after the calcitonin treatment for the fibrous dysplasia of the maxilla in immature people. Data of this case may provide a clue to the pathogenesis of fibrous dysplasia. Surgical intervention can be performed after the local bone calcification by a calcitonin treatment, because of alleviation of vigorous hemorrhage by the bone remodeling.
Yasuoka
Tadashi
T
Department of Oral and Maxillofacial Surgery, Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500-8705, Japan. yasuoka@cc.gifu-u.ac.jp
Takagi
Norio
N
Hatakeyama
Daijiro
D
Yokoyama
Kyoko
K
D016723:Bone Remodeling / Q000187:drug effects*; D002116:Calcitonin / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005358:Fibrous Dysplasia, Monostotic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008437:Maxilla / Q000503:physiopathology*; D011859:Radiography
D002116:Calcitonin