ARF requiring hemodialysis after accidental perchloroethylene ingestion.
Perchloroethylene (PCE) is an unsaturated chlorinated hydrocarbon in the form of a colorless, volatile liquid that is used as an industrial organic solvent for metal degreasing and for dry cleaning. The majority of cases of PCE intoxication have occurred by chronic inhalation, and PCE has been implicated previously in the development of mild renal dysfunction. However, the acute effects of PCE on the kidney are not well characterized, and the authors know of no reports of renal biopsy findings in the human. Here the case of a 32-year-old man who manifested by semicomatose state and oliguric acute renal failure requiring dialysis after accidental ingestion of 75 g of PCE is presented. A renal biopsy performed on the 19th day after ingestion showed features characteristic of severe acute tubular necrosis: aggregations of triangular or rhomboid crystals in the tubular lumens. A von Kossa stain showed that the crystal deposits were strongly positive for calcium. After 5 hemodialyses and conservative treatment, renal function gradually returned to normal.
Choi
Yong Ho
YH
Department of Internal Medicine, Soonchunghyang University Chonan Hospital, Chonan, Korea.
Kim
Nari
N
Seo
Youn Suk
YS
Choi
Soo Jeong
SJ
Yang
Jong Oh
JO
Lee
Eun-Young
EY
Hong
Sae Yong
SY
Lee
Hyun Soon
HS
D000062:Accidents, Occupational; D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000379:methods*; D013750:Tetrachloroethylene / Q000506:poisoning*
D013750:Tetrachloroethylene