Prospective clinical evaluation of the serologic tuberculous glycolipid test in combination with the nucleic acid amplification test.
We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions.
Maekura
Ryoji
R
Toneyama National Hospital, Osaka, Japan. maekurat@toneyama@toneyama.hosp.go.jp
Kohno
Hiroaki
H
Hirotani
Atsushi
A
Okuda
Yoshinari
Y
Ito
Masami
M
Ogura
Takeshi
T
Yano
Ikuya
I
D004269:DNA, Bacterial / Q000032:analysis; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques; D011446:Prospective Studies; D012698:Serologic Tests; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*
D004269:DNA, Bacterial; D006017:Glycolipids