title: Prognostic factors for chronic active Epstein-Barr virus infection.
abstract: Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-morbidity disease. To clarify the prognostic factors, a national survey was performed in Japan, and data for 82 patients who met the criteria for CAEBV were analyzed. Of these 82 patients, 47 were alive and 35 had already died. Multivariate analysis revealed that thromobocytopenia and age at disease onset were correlated with mortality. The probability of 5-year survival was 0.45 for older patients (onset age, > or = 8 years), 0.94 for younger patients (P<.001), 0.38 for patients with thrombocytopenia (platelet count < 12 x 10(4) platelets/microL at diagnosis), and 0.76 for patients without thrombocytopenia (P=.01). Furthermore, patients with T cell infection by EBV had shorter survival times than patients with natural killer cell infection (probability of 5-year survival, 0.59 vs. 0.87; P<.009). Patients with CAEBV with late onset of disease, thrombocytopenia, and T cell infection had significantly poorer outcomes.
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkimura@med.nagoya-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kanegane
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
authors.forename: Yo
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Akihiko
authors.initials: A
authors.lastname: Maeda
authors.forename: Shosuke
authors.initials: S
authors.lastname: Imai
authors.forename: Motohiko
authors.initials: M
authors.lastname: Okano
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokota
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Imashuku
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wakiguchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006306:Health Surveys; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D013601:T-Lymphocytes / Q000821:virology; D013921:Thrombocytopenia / Q000175:diagnosis