Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate.
A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore.
Alper
Phil B
PB
The Genomics Institute of the Novartis Foundation, 10675 John Jay Hopkins, San Diego, California 92121-1125, USA. palper@gnf.org
Nguyen
KhanhLinh T
KT