title: New roles for old proteins in adult CNS axonal regeneration.
abstract: The past year has yielded many insights and a few surprises in the field of axonal regeneration. The identification of oligodendrocyte-myelin glycoprotein as an inhibitor of axonal growth, and the discovery that the three major myelin-associated inhibitors of CNS regeneration share the same functional receptor, has launched a new wave of studies that aim to identify the signaling components of these inhibitory pathways. These findings also offer new avenues of research directed toward blocking possible therapeutic targets that inhibit regeneration and toward encouraging axonal regeneration in the CNS after injury.
authors.affiliation: Department of Biological Sciences, Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10021, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Spencer
authors.forename: Marco
authors.initials: M
authors.lastname: Domeniconi
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Cao
authors.forename: Marie T
authors.initials: MT
authors.lastname: Filbin
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D002490:Central Nervous System / Q000254:growth & development / Q000293:injuries* / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism / Q000503:physiopathology; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009185:Myelin Proteins / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D009185:Myelin Proteins; D011956:Receptors, Cell Surface