[The effect of unithiol on the changes in immunotoxicity of 2-chloroethenylchloroarsine].
The results of experiments on Wistar rats under conditions of acute intoxication with 2-chloroethenyldichloroarsine (beta-chlorovinyldichloroarsine) (0.75 LD50) showed that unithiol increases antiinfectious nonspecific resistance (NSR) of the organism. This is manifested by improved NSR characteristics: increased activity of the natural killer cells, predominant formation of antibodies to thymus-dependent antigen, and development of delayed-type hypersensitivity. However, no complete recovery of the NSR parameters impaired by 2-chloroethenyldichloroarsine is observed.
Zabrodskiĭ
P F
PF
Toxicology Department, Saratov State Medical University, ul. Il'inskaya 17, Saratov, 410037 Russia.
Germanchuk
V G
VG
Nodel'
M L
ML
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000931:Antidotes / Q000627:therapeutic use*; D020261:Arsenic Poisoning / Q000276:immunology* / Q000517:prevention & control; D001152:Arsenicals; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007928:Lethal Dose 50; D051381:Rats; D017208:Rats, Wistar; D014494:Unithiol / Q000627:therapeutic use*
D000931:Antidotes; D001152:Arsenicals; C035965:lewisite; D014494:Unithiol