title: Migraine preventive medication reduces resource utilization.
abstract: OBJECTIVE
  To determine if long-term resource utilization is reduced by adding a preventive medication to a migraine management regimen that already includes acute medication.
  
  
  BACKGROUND
  In 2000, new evidence-based guidelines for the treatment of migraine were released by the US Headache Consortium and the American Academy of Neurology. Although these guidelines emphasize the role of preventive medication in achieving significant clinical improvement, little yet is known concerning the impact of such management on medical and pharmaceutical resources. Methods.-Resource utilization information in a large claims database was analyzed retrospectively.
  
  
  RESULTS
  Adding a preventive medication to migraine management reduced the use of other migraine medications, as well as visits to physician offices and emergency departments. In addition, both acute and preventive medications were associated with lower utilization of computed tomography and magnetic resonance imaging scans.
  
  
  CONCLUSIONS
  Migraine preventive drug therapy is effective in reducing resource consumption when added to therapy consisting only of an acute medication.
authors.affiliation: Department of Neurology, Jefferson Headache Center, Thomas Jefferson College of Medicine, Philadelphia, Pa 19107, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Silberstein
authors.forename: Paul K
authors.initials: PK
authors.lastname: Winner
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Chmiel
mesh_terms: D000639:Amitriptyline / Q000191:economics / Q000627:therapeutic use*; D015331:Cohort Studies; D006295:Health Resources / Q000706:statistics & numerical data*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy / Q000191:economics / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D017366:Serotonin Receptor Agonists / Q000191:economics / Q000627:therapeutic use; D018170:Sumatriptan / Q000191:economics / Q000627:therapeutic use; D014481:United States; D014635:Valproic Acid / Q000191:economics / Q000627:therapeutic use*
chemical_list: D017366:Serotonin Receptor Agonists; D000639:Amitriptyline; D014635:Valproic Acid; D018170:Sumatriptan