How the ubiquitin-proteasome system controls transcription.
Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.
Muratani
Masafumi
M
Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, New York 11724, USA.
Tansey
William P
WP
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*
D002843:Chromatin; D025801:Ubiquitin; D014452:Ubiquitins; D012321:DNA-Directed RNA Polymerases; D010450:Endopeptidases