CD62 expression during thrombus formation.
A large right atrial mass was discovered in a 16-year-old female patient receiving chemotherapy treatment for Hodgkin disease. The patient was participating in a platelet function research study. During laboratory examination of platelet activation, increasing CD62 and CD63 expression were found to mirror the clot formation. Further investigation of platelet expression of CD62 and CD63 by flow cytometry might reveal it to be a valuable tool in predicting impending thrombus formation.
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Kay L
KL
Children's Hospital of Illinois, Department of Pediatrics, IL 61637, USA. kls@uic.edu
Mankin
Peggy E
PE
D000293:Adolescent; D015703:Antigens, CD / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019007:P-Selectin / Q000097:blood*; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D013927:Thrombosis / Q000097:blood*
D015703:Antigens, CD; C554586:CD63 protein, human; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30