An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women.
Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoproteincholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoproteincholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.
Mutlu-Türkoğlu
U
U
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, 34390 Istanbul, Turkey. umturk@istanbul.edu.tc
Oztezcan
S
S
Telci
A
A
Orhan
Y
Y
Aykaç-Toker
G
G
Sivas
A
A
Uysal
M
M
D000328:Adult; D001161:Arteriosclerosis / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D010084:Oxidation-Reduction; D012307:Risk Factors; D013223:Statistics as Topic
D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D002784:Cholesterol