title: Production of macrosphelide A by the mycoparasite Coniothyrium minitans.
abstract: Coniothyrium minitans, a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum, produced four closely related metabolites inhibitory to fungal growth. The major metabolite, identified as macrosphelide A, had IG(50) values (the concentration of metabolite to inhibit growth by 50%) of 46.6 and 2.9 microgram ml(-1) against S. sclerotiorum and S. cepivorum, respectively. This is the first report of both antifungal activity due to macrosphelide A as well as isolation of macrosphelide A from C. minitans.
authors.affiliation: Department of Plant Biology, Scottish Agricultural College, Ayr Campus, Auchincruive Estate, KA6 5HW, Ayr, UK. m.mcquilken@au.sac.ac.uk
authors.forename: Mark P
authors.initials: MP
authors.lastname: McQuilken
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Gemmell
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hill
authors.forename: John M
authors.initials: JM
authors.lastname: Whipps
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D018533:Biomass; D017077:Culture Media, Conditioned; D006571:Heterocyclic Compounds / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010935:Plant Diseases / Q000382:microbiology; D014675:Vegetables / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017077:Culture Media, Conditioned; D006571:Heterocyclic Compounds; C097798:macrosphelide A