title: Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines.
abstract: Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an alpha-helical structure is important for their effectiveness against this pathogen.
authors.affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. louise.rollins-smith@vanderbilt.edu
authors.forename: Louise A
authors.initials: LA
authors.lastname: Rollins-Smith
authors.forename: Cynthia
authors.initials: C
authors.lastname: Carey
authors.forename: J Michael
authors.initials: JM
authors.lastname: Conlon
authors.forename: Laura K
authors.initials: LK
authors.lastname: Reinert
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Doersam
authors.forename: Tomas
authors.initials: T
authors.lastname: Bergman
authors.forename: Jerzy
authors.initials: J
authors.lastname: Silberring
authors.forename: Hilkka
authors.initials: H
authors.lastname: Lankinen
authors.forename: David
authors.initials: D
authors.lastname: Wade
mesh_terms: D019943:Amino Acid Substitution; D000663:Amphibians / Q000382:microbiology*; D000820:Animal Diseases / Q000635:transmission*; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000635:transmission / Q000662:veterinary*; D011153:Population; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014862:Wasp Venoms / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D011506:Proteins; D014862:Wasp Venoms; C104501:temporin