Human papillomavirus types 16, 31, and 58 use different endocytosis pathways to enter cells.
The early steps of the intracellular trafficking of human papillomavirus type 16 (HPV-16), -31, and -58 pseudovirions were studied by investigating the effects of drugs acting at defined points of endocytosis pathways on virus-like particle-mediated pseudoinfection by overexpression of a dominant-negative form of the Eps15 protein to inhibit clathrin-mediated endocytosis and by electron microscopy. The results obtained suggested the involvement of clathrin-mediated endocytosis in HPV-16 and HPV-58 entry and caveola-mediated endocytosis in HPV-31 entry.
Bousarghin
Latifa
L
Laboratoire de Virologie Moléculaire, INSERM EMIU 00-10 et USC INRA, Faculté des Sciences Pharmaceutiques, Tours, France.
Touzé
Antoine
A
Sizaret
Pierre-Yves
PY
Coursaget
Pierre
P
D000818:Animals; D019556:COS Cells; D021941:Caveolae / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008854:Microscopy, Electron; D027383:Papillomaviridae / Q000145:classification / Q000472:pathogenicity*; D014771:Virion / Q000472:pathogenicity
D002966:Clathrin