title: The value of the PedsQLTM in assessing quality of life in survivors of childhood cancer.
abstract: OBJECTIVE
  To determine differences in ratings of quality of life (QOL) depending on respondent (mother or child) and implications for the validity of measures of QOL, and interpretation of scores.
  
  
  METHODS
  Forty-five survivors of acute lymphoblastic leukaemia (ALL) and 23 survivors of central nervous system (CNS) tumours and their mothers completed a generic measure of QOL: the Pediatric Quality of Life Inventory Version 4.0 (PedsQL 4.0; Varni et al., 2001).
  
  
  RESULTS
  Although correlations between mother and survivor ratings were largely moderate to good, further analyses showed that mothers reported QOL to be worse than survivors. Both mothers and survivors rated physical health worse than psychological health, and survivors of a CNS tumour had poorer QOL than survivors of ALL. Although survivors of ALL reported reasonably good physical health, their psychosocial health was more adversely affected.
  
  
  CONCLUSIONS
  Implications for further use of the PedsQL 4.0 in the clinical or research context are discussed. Incidental findings highlight some limitations of the PedsQL 4.0 for work with this population.
authors.affiliation: Cancer Research UK Child, University of Sheffield, Sheffield, UK. c.eiser@sheffield.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Eiser
authors.forename: Y H
authors.initials: YH
authors.lastname: Vance
authors.forename: B
authors.initials: B
authors.lastname: Horne
authors.forename: A
authors.initials: A
authors.lastname: Glaser
authors.forename: H
authors.initials: H
authors.lastname: Galvin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016543:Central Nervous System Neoplasms / Q000523:psychology; D002648:Child; D004739:England; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D009035:Mothers; D009369:Neoplasms / Q000523:psychology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000523:psychology; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D012737:Sex Factors; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology*