title: Comedolysis by a lipohydroxyacid formulation in acne-prone subjects.
abstract: Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this environmental related disease. This compound is commonly called beta-lipohydroxyacid (LHA). Among a randomized group of 14 acne-prone women, 12 who developed cornified follicular plugs the end of summertime were treated by the LHA formulation twice daily for 2 weeks. Ten of 14 other women who presented the same skin condition remained untreated as controls. The comedolytic effect was assessed using non-invasive ultraviolet-light video recording combined with computerized image analysis. The cornified follicular plugs were progressively cleared in 10/12 LHA-treated women and in 3/10 untreated volunteers. Analytical assessments showed a significant decrease in both the number and total size of microcomedones in the LHA-treated women. By contrast, no quantitative change was disclosed in the untreated group. It is concluded that the tested LHA formulation exerts comedolytic properties that might help in preventing post-summertime acne exacerbations.
authors.affiliation: Department of Dermatopathology, University Medical Center, CHU du Sart Tilman Liège, Belgium.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uhoda
authors.forename: Claudine
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.forename: Gérald E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000328:Adult; D005260:Female; D006801:Humans; D012459:Salicylates / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*
chemical_list: C113468:2-hydroxy-5-octanoylbenzoic acid; D012459:Salicylates