T-cell differentiation: chromatin remodelling in CD4/CD8 regulation.
CD4 and CD8 genes are integral indicators of T-cell lineage commitment. New insights into the control of expression of these genes have come from recent reports implicating chromatin-remodelling factors in their regulation.
Zamoyska
Rose
R
Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK. rzamoys@nimr.mrc.ac.uk
D000818:Animals; D015704:CD4 Antigens / Q000235:genetics / Q000502:physiology*; D016827:CD8 Antigens / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002843:Chromatin / Q000502:physiology*; D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D051379:Mice; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D013601:T-Lymphocytes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D015704:CD4 Antigens; D016827:CD8 Antigens; D002843:Chromatin; D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C493730:Runx3 protein, mouse; D014157:Transcription Factors