title: Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids.
abstract: Eleven homoisoflavonoids and two xanthones were isolated and characterized from the bulbs of Ledebouria graminifolia. Five of the homoisoflavonoids are new compounds and were identified as: 5-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)-4-chromanone, 5-hydroxy-6,7-dimethoxy-3-(4'-hydroxybenzyl)-4-chromanone, 5,7,8-trimethoxy-3-(4'-hydroxybenzyl)-4-chromanone, 5-hydroxy-3',4',7-trimethoxyspiro[2H-1-benzopyran-7'-bicyclo[4.2.0]octa-trien]-4-one, 5,7-dihydroxy-3',4'-dimethoxyspiro[2H-1-benzopyran-7'-bicyclo[4.2.0]octa-trien]-4-one. Structures were elucidated by extensive 1D, and 2D NMR spectroscopy and HRMS. A method for tissue culture was developed and the bulbs of mature plants were found to contain all the compounds isolated from the wild specimens of L. graminifolia.
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag 00704, Gaborone, Botswana.
authors.forename: Joan
authors.initials: J
authors.lastname: Mutanyatta
authors.forename: Bhagali G
authors.initials: BG
authors.lastname: Matapa
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Shushu
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D046508:Culture Techniques / Q000379:methods; D006801:Humans; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry* / Q000145:classification / Q000166:cytology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014966:Xanthenes / Q000737:chemistry* / Q000302:isolation & purification; D044004:Xanthones
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D007529:Isoflavones; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone