Ergotism associated with HIV antiviral protease inhibitor therapy.
Ergotism is a rare condition of acute vasospasm found classically in young and middle-aged women taking ergot alkaloid agents to treat migraine headache. We report the case of a young man with human immunodeficiency virus (HIV) positivity and describe the drug interaction between protease inhibitors and ergot alkaloid agents, which most likely predisposed to development of ergot toxicity. The HIV-positive population receiving antiviral therapy may be an under-recognized group at risk for ergotism through decreased hepatic metabolism of ergot preparations.
Baldwin
Zachary K
ZK
Department of Surgery, Kaiser Permanente-Oakland, 280 W MacArthur Boulevard, Oakland, CA 94611, USA.
Ceraldi
Chris C
CC
D000328:Adult; D000792:Angiography; D004347:Drug Interactions; D004878:Ergotamine / Q000009:adverse effects*; D004881:Ergotism / Q000209:etiology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
D017320:HIV Protease Inhibitors; D014662:Vasoconstrictor Agents; D004878:Ergotamine