[Study on the inclusion compound of qucertin with hydroxypropyl-beta-cyclodextrin].
The inclusion compound of qucertin-HP-beta-CD was manufactured by aqueous solution-stirring method. The inclusion compound of qucertin-HP-beta-CD was confirmed by IR spectroscopy and differential theramal analysis (DTA). The results indicated that the inclusion compound of qucertion-HP-beta-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of qucertin to HP-beta-CD was 1:1. The solubility of qucertin increased when the drug was included by HP-beta-CD, which in water has added from 0.0392 mg/ml to 34.227 mg/ml.
Shao
Wei
W
College of Pharmacy, Shandong University, Jinan 250012.
Xie
Qingchun
Q
Wang
Chunxiang
C
Mi
Guangtai
G
Wang
Daqing
D
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins; D004337:Drug Carriers; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011794:Quercetin