Residual hippocampal atrophy in asphyxiated term neonates.
OBJECTIVE
Previous studies have shown the hippocampus and basal ganglia to be highly sensitive to hypoxic-ischemic insult. The authors' aim was to evaluate the long-term effects of perinatal asphyxia (PA) on the hippocampus and caudate nucleus in a group of participants born at term and who met the criteria for hypoxic-ischemic encephalopathy (HIE). Additionally, the authors looked for damage in other brain regions using voxel-based morphometry (VBM).


METHODS
The sample consisted of 13 participants (8 boys and 5 girls) with a mean age at study of 16.23 years (+/- 2.89) with antecedents of perinatal asphyxia, diagnosed as moderate hypoxic-ischemic encephalopathy. A group of 13 healthy adolescents matched for age, sex, educational level, and social background were recruited as a comparison group. MR scans were acquired on a 1.5T Signa (General Electric, Milwaukee, WI) to evaluate hippocampal and caudate volumes and to perform VBM analysis. Finally, Rey's Auditory Verbal Learning Test was administered to evaluate verbal long-term memory.


RESULTS
HIE participants were found to have bilateral hippocampal atrophy (P = .015) and gray matter damage in temporal and frontal lobes. The caudate nucleus showed no atrophic changes in PA participants, and VBM analysis did not reveal other consistent brain abnormalities. Verbal long-term memory was slightly worse in HIE participants.


CONCLUSIONS
These findings indicate that PA produces hippocampal and other nonspecific long-term damage, which cannot be compensated for by plasticity mechanisms. However, this damage does not preclude normal development and scholarship.
Mañeru
Cristina
C
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, C/Casanova, 143, 08036 Barcelona, Spain.
Serra-Grabulosa
Josep M
JM
Junqué
Carme
C
Salgado-Pineda
Pilar
P
Bargalló
Núria
N
Olondo
Miren
M
Botet-Mussons
Francesc
F
Tallada
Mercé
M
Mercader
Josep Maria
JM
D000293:Adolescent; D000704:Analysis of Variance; D001238:Asphyxia Neonatorum / Q000150:complications / Q000473:pathology*; D001284:Atrophy / Q000209:etiology; D002421:Caudate Nucleus / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000473:pathology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology; D012494:Sampling Studies; D013997:Time Factors