Internuclear ophthalmoplegia (INO): an unusual presentation of neuropsychiatric lupus erythematosus.
OBJECTIVE
INO in SLE is uncommon, affecting < 5% of hospitalized SLE patients. A MEDLINE search 1966-2001 revealed only 22 reported cases. INO also rarely presents with diplopia. We report such a case.


METHODS
A 35 year old woman with long standing SLE developed the abrupt onset of diplopia, vertigo and ataxia. Physical examination was remarkable only for the neurologic examination with a left INO and abnormal cerebellar testing. Treatment with corticosteroids and intravenous cyclophosphamide resulted in resolution of her cerebellar and ocular symptoms.
Abel
Michael P
MP
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas, USA.
Murphy
Frederick T
FT
Enzenauer
Raymond J
RJ
Enzenauer
Robert W
RW
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D004172:Diplopia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008775:Methylprednisolone / Q000627:therapeutic use; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone