title: Breast cancer detection in gadolinium-enhanced MR images by static region descriptors and neural networks.
abstract: OBJECTIVE
  To automate the diagnosis of malignancy by classifying breast tissues as negative or positive for malignancy in gadolinium-enhanced dynamic magnetic resonance (MR) images, using static region descriptors and a neural network classifier.
  
  
  METHODS
  We propose a novel approach whereby the classifier evaluates a number of parameters that identify important tumor characteristics, as obtained by digital image processing techniques. These parameters include static signal intensity (SI) after contrast enhancement, mass margin descriptors, evaluation of mass shape by calculation of eccentricity, mass size, and mass granularity by texture analysis. Datasets for 14 patients were obtained by use of the 1.5T PMRTOW Clinical Imager.
  
  
  RESULTS
  Statistical performance evaluation of the neural networks indicated 90%-100% sensitivity, 91%-100% specificity, and 91%-100% accuracy.
  
  
  CONCLUSIONS
  Although this work is preliminary, it may reduce overall health-care time and costs, and enable higher accuracy in automated breast cancer detection systems.
authors.affiliation: Computer Science Department, University of North Carolina-Charlotte, Charlotte, North Carolina 28036-1621, USA.
authors.forename: Angelina A
authors.initials: AA
authors.lastname: Tzacheva
authors.forename: Kayvan
authors.initials: K
authors.lastname: Najarian
authors.forename: John P
authors.initials: JP
authors.lastname: Brockway
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D016571:Neural Networks, Computer
chemical_list: D003287:Contrast Media; D005682:Gadolinium