A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat.
OBJECTIVE
This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop.


RESULTS
Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms.


CONCLUSIONS
This sympathetic modulation of leptin expression has potential implications for regulation of body fat.
Mark
A L
AL
Specialized Center of Research in Hypertension Genetics, the Department of Internal Medicine, Lucille A Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA 52242-1101, USA.
Rahmouni
K
K
Correia
M
M
Haynes
W G
WG
D000273:Adipose Tissue / Q000502:physiology*; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage; D007668:Kidney / Q000502:physiology; D020738:Leptin / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D012333:RNA, Messenger / Q000032:analysis; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D054411:Receptors, Leptin; D013564:Sympathetic Nervous System / Q000502:physiology*
D000318:Adrenergic beta-Agonists; C515448:LEPR protein, human; D020738:Leptin; D012333:RNA, Messenger; D011943:Receptors, Adrenergic, beta; D054411:Receptors, Leptin; D007545:Isoproterenol; D004837:Epinephrine