title: HIV-related Hodgkin's disease with central nervous system involvement and association with Epstein-Barr virus.
abstract: Central nervous system (CNS) involvement is a rare occurrence in the course of human immunodeficiency virus (HIV)-related Hodgkin's disease (HD). We report the clinical course of a patient with HIV infection who developed systemic HD, mixed cellularity subtype, later complicated by leptomeningeal involvement. The patient died from his illness, and autopsy was performed. Examining the brain lesion, Epstein-Barr virus (EBV) presence was demonstrated in Reed-Sternberg cells by immunohistochemistry using an EBER probe for EBV RNA. This is the second case report in the English literature of HD involving the CNS in an HIV-positive individual, and the first demonstrating EBV presence. Extranodal presence of Hodgkin's disease in patients with HIV infection is probably related to immunosuppression, and physicians treating this illness should be alert to the potential of unusual sites of involvement.
authors.affiliation: Department of Medicine, Division of Oncology-Hematology, Ben Taub General Hospital, Baylor College of Medicine, Houston, Texas 77030, USA. sam@bcm.tmc.edu
authors.forename: Suleiman
authors.initials: S
authors.lastname: Massarweh
authors.forename: Mark M
authors.initials: MM
authors.lastname: Udden
authors.forename: Imran
authors.initials: I
authors.lastname: Shahab
authors.forename: Michael
authors.initials: M
authors.lastname: Kroll
authors.forename: David A
authors.initials: DA
authors.lastname: Sears
authors.forename: Garrett R
authors.initials: GR
authors.lastname: Lynch
authors.forename: Bin S
authors.initials: BS
authors.lastname: Teh
authors.forename: Hsin H
authors.initials: HH
authors.lastname: Lu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001706:Biopsy; D001761:Bleomycin / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology* / Q000821:virology; D003606:Dacarbazine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology / Q000821:virology; D006716:Homosexuality; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D016539:Reed-Sternberg Cells / Q000821:virology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin