title: [Effects of silkworm pupa oil on serum lipids level and platelet function in rats].
abstract: To observe the effects of silkworm pupa oil on serum lipids level and platelet function in rats, according to serum TG, TC level, 40 male Wistar rats are divided into four groups (normal control group, high fat control group, silkworm pupa oil group and silkworm pupa oil + VE group). The rats are fed different diets and six weeks later, serum lipids level and platelet function are measured. The results show that (1) Compared with high fat control group, serum TC, TG, LDL-C level, AI value, Platelet aggregability, plasma TXB2 level and T/P ratio decrease significantly while HDL-C level and 6-k-PGF1 level increase in silkworm pupa oil group; (2) Serum TC, LDL-C level, T/P ratio and platelet aggregability are significantly lower in silkworm pupa oil + VE group than in silkworm pupa oil group. It is suggested that silkworm pupa oil rich in alpha-linolenic acid can reduce serum lipids level and inhibit platelet aggregation, which is more effective with the supplementation with VE.
authors.affiliation: Department of Nutrition and Hygiene, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yang
authors.forename: Lianzhen
authors.initials: L
authors.lastname: Huang
authors.forename: Jianping
authors.initials: J
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000818:Animals; D012831:Bombyx / Q000737:chemistry*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009821:Oils / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011679:Pupa / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology; D017962:alpha-Linolenic Acid / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D009821:Oils; D010975:Platelet Aggregation Inhibitors; D017962:alpha-Linolenic Acid; D014810:Vitamin E