title: Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene.
abstract: OBJECTIVE
  The molecular basis of neuroleptic malignant syndrome (NMS) is unclear, but clinical studies have noted a genetic predisposition. A recent genetic study suggested an association between NMS and the I A polymorphism in the dopamine D2 receptor (DRD2 ) gene. We further examined the association in a larger number of subjects.
  
  
  METHODS
  We studied 49 Japanese patients previously diagnosed with NMS, and 123 schizophrenic patients treated with neuroleptics without occurrence of NMS. PCR and RFLP analyses were performed to screen the I A polymorphism.
  
  
  RESULTS
  The I A1 allele frequency was 0.408 in NMS patients and 0.415 in patients without NMS. No significant differences in allelic or genotypic frequencies were observed between the two groups.
  
  
  CONCLUSIONS
  We cannot conclude that the I A polymorphism is associated with development of NMS.
authors.affiliation: Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kishida
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kawanishi
authors.forename: Taku
authors.initials: T
authors.lastname: Furuno
authors.forename: Takehiko
authors.initials: T
authors.lastname: Matsumura
authors.forename: Hana
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Naoya
authors.initials: N
authors.lastname: Sugiyama
authors.forename: Kyoko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Yamada
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D044466:Asian People; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D009459:Neuroleptic Malignant Syndrome / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D019914:Taq Polymerase
chemical_list: D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase