Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1).
Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the leaves of Hymenaea palustris Ducké led to the isolation of six cancer cell growth inhibitory flavonoids (1-6). The structures were elucidated by HRMS and 1D and 2D NMR spectral analysis. The new flavonolignan 1 designated palstatin proved to be a methoxy structural modification of 5'-methoxyhydnocarpin-D (2). Flavones 1-4 inhibited growth of the pathogenic bacteria Enterococcus faecalis and/or Neisseria gonorrhoeae.
Pettit
George R
GR
Cancer Research Institute, Department of Chemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. bpettit@asu.edu
Meng
Yanhui
Y
Stevenson
Clare A
CA
Doubek
Dennis L
DL
Knight
John C
JC
Cichacz
Zbigniew
Z
Pettit
Robin K
RK
Chapuis
Jean-Charles
JC
Schmidt
Jean M
JM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D013293:Enterococcus faecalis / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010568:Peru; D018515:Plant Leaves / Q000737:chemistry; D014197:Trees / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C475239:palstatin