The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug.
The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
Davies
Murray S
MS
Department of Chemistry, University of Western Australia, Crawley, WA 6009, Australia.
Berners-Price
Susan J
SJ
Cox
John W
JW
Farrell
Nicholas
N
D000970:Antineoplastic Agents / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004247:DNA / Q000737:chemistry*; D018736:DNA Adducts / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013698:Templates, Genetic
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D018736:DNA Adducts; D004277:DNA, Single-Stranded; D009944:Organoplatinum Compounds; D004247:DNA