Variations in affect following amphetamine and placebo: markers of stimulant drug preference.
Variations in affect following d-amphetamine and placebo were examined in healthy young adults who subsequently preferred d-amphetamine (choosers; n = 61) or placebo (nonchoosers; n = 48) in a drug preference procedure. Affect was assessed before and 1, 3, and 6 hr after participants received the placebo and 10 mg d-amphetamine. Following amphetamine as compared with placebo, choosers' ratings increased on scales measuring energy, cognitive efficiency, and well-being, and decreased on scales measuring fatigue and sedation. Nonchoosers reported no effects, sedative effects, and dysphoric effects of amphetamine. Following placebo, ratings of energy, efficiency, and well-being decreased, and ratings of sedation increased in choosers but not in nonchoosers. Variations in affect following placebo and amphetamine may constitute markers of risk for drug use.
Gabbay
Frances H
FH
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. fgabbay@usuhs.mil
D000328:Adult; D000339:Affect / Q000187:drug effects; D000661:Amphetamine / Q000494:pharmacology*; D019969:Amphetamine-Related Disorders / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D004644:Emotions / Q000187:drug effects*; D005221:Fatigue / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D012959:Socioeconomic Factors
D000697:Central Nervous System Stimulants; D000661:Amphetamine