An analysis of ISO intracutaneous reactivity test results to justify a reduction in animal requirements.
The ISO intracutaneous reactivity test is the standard protocol for determining a medical device's potential for causing irritation. The authors present data indicating that the number of animals required per test can be reduced from three rabbits to two.
Upman
Paul J
PJ
NAMSA, 2261 Tracy Road, Northwood, OH 43619, USA. pupman@namsa.com.
Anderson
Jason
J
Tasse
Laura
L
D000827:Animal Welfare; D000818:Animals; D004353:Drug Evaluation, Preclinical; D007271:Injections, Intradermal; D007391:International Cooperation; D007428:Intradermal Tests / Q000379:methods; D007509:Irritants / Q000008:administration & dosage / Q000145:classification / Q000633:toxicity*; D011817:Rabbits; D012867:Skin / Q000187:drug effects*
D007509:Irritants