title: Fenvalerate-induced macromolecular changes in the catfish, Clarias batrachus.
abstract: The effects of sublethal concentration of fenvalerate on DNA, RNA, RNA/DNA ratio and protein contents were estimated in gill and kidney tissues of an air breathing fish, Clarias batrachus. Fenvalerate reduced the DNA content in gill, whereas it did not produce any significant effect on DNA in kidney. This tissue-specific change in DNA content may be due to differential effects of fenvalerate or its metabolite(s) on synthesis and/degradation of DNA in gill and kidney cells of the fish. RNA and protein contents declined substantially in both the tissues in response to fenvalerate treatment. However, RNA/DNA ratio remains unchanged. It indicates that decrease in protein content in response to fenvalerate treatment might have been brought about by reduce rate of translation of messenger (mRNA) without a decrease in concentration of ribosomes.
authors.affiliation: Department of Zoology, J.N.V. University, Jodhpur-342 001, India.
authors.forename: G
authors.initials: G
authors.lastname: Tripathi
authors.forename: S
authors.initials: S
authors.lastname: Harsh
authors.forename: P
authors.initials: P
authors.lastname: Verma
mesh_terms: D000818:Animals; D002397:Catfishes / Q000502:physiology*; D004247:DNA / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D005880:Gills / Q000737:chemistry; D007306:Insecticides / Q000009:adverse effects*; D007668:Kidney / Q000737:chemistry; D009570:Nitriles; D011722:Pyrethrins / Q000009:adverse effects*; D012313:RNA / Q000032:analysis*
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D012313:RNA; D004247:DNA; C017690:fenvalerate