title: Investigation of placental stem villi arteries in fetally growth-restricted pregnancies: a multivariate analysis.
abstract: Thirteen placentas were studied from 5 normal pregnancies and 8 from pregnancies complicated by fetal growth restriction (4 with present, 3 with absent, and 1 with reversed end-diastolic velocities at Doppler interrogation of the umbilical arteries). On immunohistochemically stained slides, the diameter (d) and the wall thickness (t) of the arterial vasculature of the stem villi were measured for a total of approximately 10,000 vessels. A multivariate 'mixed effect model' statistical analysis was performed using d and t as dependent variables and gestational age, delivery mode, fetal and placental weight, the degree of vascular collapse and Doppler blood flow patterns as independent variables. Gestational age, Doppler pattern and the degree of vascular collapse significantly affected both d and t, the mode of delivery influenced d while fetal and placental weights scarcely affected the dependent variables. The above parameters should therefore be taken into account when investigating placental stem vessel morphometry.
authors.affiliation: Department of Neuroscience, University of Turin, Turin, Italy. caterina.guiot@unito.it
authors.forename: C
authors.initials: C
authors.lastname: Guiot
authors.forename: R
authors.initials: R
authors.lastname: Russo
authors.forename: A
authors.initials: A
authors.lastname: Sciarrone
authors.forename: M
authors.initials: M
authors.lastname: Biolcati
authors.forename: E
authors.initials: E
authors.lastname: Piccoli
authors.forename: P
authors.initials: P
authors.lastname: Kaufmann
authors.forename: T
authors.initials: T
authors.lastname: Todros
mesh_terms: D001724:Birth Weight; D001783:Blood Flow Velocity; D002824:Chorionic Villi / Q000098:blood supply* / Q000000981:diagnostic imaging; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015233:Models, Statistical; D015999:Multivariate Analysis; D011247:Pregnancy; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000033:anatomy & histology / Q000000981:diagnostic imaging