Alcohol metabolism: role in toxicity and carcinogenesis.
This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz.
Badger
Thomas M
TM
Arkansas Children's Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA. badgerthomasm@uams.edu
Ronis
Martin J J
MJ
Seitz
Helmut K
HK
Albano
Emanuele
E
Ingelman-Sundberg
Magnus
M
Lieber
Charles S
CS
D000426:Alcohol Dehydrogenase / Q000235:genetics / Q000502:physiology*; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000818:Animals; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000502:physiology*; D016207:Cytokines / Q000097:blood; D000431:Ethanol / Q000493:pharmacokinetics* / Q000633:toxicity*; D005770:Gastrointestinal Neoplasms / Q000201:enzymology / Q000209:etiology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors
D016207:Cytokines; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D019392:Cytochrome P-450 CYP2E1