title: Traces of human migrations in Helicobacter pylori populations.
abstract: Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive their gene pools from ancestral populations that arose in Africa, Central Asia, and East Asia. Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade.
authors.affiliation: Department of Molecular Biology, Max-Planck Institut für Infektionsbiologie, 10117 Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Falush
authors.forename: Thierry
authors.initials: T
authors.lastname: Wirth
authors.forename: Bodo
authors.initials: B
authors.lastname: Linz
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pritchard
authors.forename: Matthew
authors.initials: M
authors.lastname: Stephens
authors.forename: Mark
authors.initials: M
authors.lastname: Kidd
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Blaser
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.forename: Sylvie
authors.initials: S
authors.lastname: Vacher
authors.forename: Guillermo I
authors.initials: GI
authors.lastname: Perez-Perez
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.forename: Kristina
authors.initials: K
authors.lastname: Otto
authors.forename: Ulrike
authors.initials: U
authors.lastname: Reichard
authors.forename: Elena
authors.initials: E
authors.lastname: Katzowitsch
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Mark
authors.initials: M
authors.lastname: Achtman
authors.forename: Sebastian
authors.initials: S
authors.lastname: Suerbaum
mesh_terms: D000349:Africa; D000383:Agriculture; D000569:Americas; D001208:Asia; D001426:Bacterial Proteins / Q000235:genetics; D001499:Bayes Theorem; D004641:Emigration and Immigration; D005006:Ethnicity; D005060:Europe; D005798:Genes, Bacterial; D014644:Genetic Variation; D005828:Genetics, Population; D005843:Geography; D016481:Helicobacter Infections / Q000382:microbiology* / Q000635:transmission; D016480:Helicobacter pylori / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007198:Indians, North American; D007802:Language; D011110:Polymorphism, Genetic; D011114:Polynesia; D044469:Racial Groups; D011995:Recombination, Genetic; D012940:Social Problems; D012984:Software
chemical_list: D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori