Can CK-MB and cTn-I be detected in the peripheral circulation within the first 10 min of acute coronary ischemia?
There are approximately 4 million patients hospitalized with suspected acute coronary syndromes (ACS) annually. However, the current standard tools for assessing ACS in the Emergency Department are felt to have insufficient sensitivity and specificity. Animal studies have demonstrated that CK-MB and troponin-I are released in a biphasic pattern with an initial transient release which peaks and falls within the first 10 min of ischemia. We hypothesize that transient elevations of CK-MB and troponin-I can be detected in the peripheral circulation within the first 10 min of ischemia in a human model of brief coronary ischemia. We also present results from our pilot study that failed to confirm this hypothesis; however, this pilot studied was insufficiently powered to detect potentially clinically important results.
Smithline
Howard A
HA
Department of Emergency Medicine, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA. gail.kolodziej@bhs.org
Thompson
Michael
M
Moran
Christopher
C
Mader
Timothy J
TJ
D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D005080:Exercise Test; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D017202:Myocardial Ischemia / Q000378:metabolism*; D010865:Pilot Projects; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form