title: Extra-renal erythropoietin secretion after bilateral nephrectomy.
abstract: Serum concentrations of erythropoietin and soluble transferrin receptor were examined immediately after removal of the remaining kidney in a patient with a history of unilateral radical nephrectomy. Unexpectedly, the erythropoietin concentration increased from 18.2 U/L to 42.5 within 6 h after the operation. Soluble transferrin receptor (TfR) concentration rapidly decreased from 2,725 microgram/L to 1,548 during the 12-h postoperative period. Extra-renal erythropoietin secretion could increase to more than twice as much as the renal secretion of erythropoietin immediately after the loss of renal tissue, and the rise in erythropoietin could accelerate the recycling of TfR, thus causing a decrease in its serum concentration.
authors.affiliation: Department of Kidney and Dialysis, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan. t-nkns@hyo-med.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Seizaburo
authors.initials: S
authors.lastname: Horikawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hiraoka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Izumi
authors.forename: Teturo
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takamitsu
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D004921:Erythropoietin / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology* / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods; D011990:Receptors, Transferrin / Q000097:blood; D012083:Renin / Q000097:blood; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D011990:Receptors, Transferrin; D004921:Erythropoietin; D012083:Renin