Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus.
Signaling by the Wnt family of secreted growth factors is involved in numerous different aspects of embryonic development and also for maintenance of cellular function in adult tissues. In addition to regulation at the transcriptional level, Wnt activity is modulated by a number of different Wnt-binding proteins. Here we report the cloning and developmental expression pattern of the Xenopus orthologue of secreted Frizzled-related protein 5 (sFRP5), an endogenous inhibitor of Wnt signaling. At early stages of endodermal differentiation, sFRP5 is expressed in the developing liver. At later stages however, sFRP5 expression is down-regulated in the liver and becomes strongly expressed in the region corresponding to the junction between the posterior portion of the stomach and the anterior intestines.
Pilcher
Karen E
KE
Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, P.O. Box 254044, Tucson, AZ 85724-5044, USA.
Krieg
Paul A
PA
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D004064:Digestive System / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D004707:Endoderm / Q000378:metabolism*; D005136:Eye Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors; D016415:Sequence Alignment; D051153:Wnt Proteins; D014981:Xenopus; D029961:Zebrafish Proteins; D000094742:Secreted Frizzled-Related Proteins
D048868:Adaptor Proteins, Signal Transducing; D005136:Eye Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins