title: [Rickettsiosis: state of the art at the turn of the 21st century].
abstract: Information about changes in the modern taxonomy of intracellular bacteria conditionally united within the nomination of "Rickettsioses" is presented in the paper. Due to a total hobby related with keeping home animals (pets), cats and dogs, apart from the cattle, joined the natural ecological cycles of rickettsioses stimulation. The morbidity of rickettsioses of the acaroid group has been persistently growing; like in case with other pathologies (Lyme's disease) involving the acaroid transfer factor, its obvious "urbanization" is pronounced. Absolute and relative morbidity indices in respect to rickettsioses, which are epidemiologically important for Russia, are presented. The modern knowledge database concerning the rickettsioses makes it possible to control the epidemic process for this infection category. It is noteworthy, that Prowazek's rickettsiosis of its both forms (i.e. the epidemic and relapsing ones), which does not have an independent cycle of circulation of its stimulator in wild nature, and unlike the acaroid group rickettsioses, turned into a socially controllable infection. It will be totally eliminated, during 10-15 years, both in Russia and the CIS countries. The practitioners are well supplied with a variety of drugs of tetracycline and fluorine-quinol groups, which makes it possible to arrest the infection process in patients rapidly and effectively and to prevent the lethal cases. A low incidence rate of rickettsioses, including Q fever, within the general infection morbidity, and taking into consideration the availability of methods for effective therapy and prevention, makes one consider a comprehensive vaccination against the discussed group of infections to be irrational. Obviously, such vaccination must be still applied in respect to a limited number of persons from among high-risk groups and for two or three varieties of rickettsioses only (i.e. Prowazek's rickettsioses, Rocky Mountain spotted fever and Q fever). Live vaccines, obtained on the basis of attenuated and recombined strains (which have a full-scale set of specific antigens), are recommended.
authors.forename: E P
authors.initials: EP
authors.lastname: Lukin
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Nesvizhskiĭ
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002415:Cats; D002417:Cattle; D004285:Dogs; D024841:Fluoroquinolones; D006801:Humans; D007114:Immunization; D011778:Q Fever / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D012281:Rickettsia / Q000276:immunology; D012282:Rickettsia Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D012283:Rickettsia prowazekii; D012373:Rocky Mountain Spotted Fever / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D012426:Russia / Q000453:epidemiology; D013752:Tetracycline / Q000627:therapeutic use; D014438:Typhus, Epidemic Louse-Borne / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001428:Bacterial Vaccines; D024841:Fluoroquinolones; D013752:Tetracycline