title: New cytotoxic furanosesterterpenes from an Okinawan marine sponge, Ircinia sp.
abstract: Five new sesterterpenes have been isolated from a lipophilic extract of a sponge, Ircinia sp., and their structures elucidated by spectroscopic and chemical methods. The absolute configurations of two metabolites (1, 3) were established by chemical degradation. These compounds showed moderate cytotoxicity against KB cells.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Hamad H
authors.initials: HH
authors.lastname: Issa
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Higa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes