[A study on morphology and distribution of mast cells in oral lichen planus].
OBJECTIVE
The aim of this study was to investigate the features of mast cell subtypes and relationship between mast cells and pathogenesis of oral lichen planus.


METHODS
Mast cells in the tissue of oral lichen planus were stained with Alcian blue/safranine in order to demonstrate mature and immature mast cells, and the constituent ratio of these two subtypes was calculated. Afterwards, LUZEX-F image pattern analysis system was applied to demonstrate the size of these two subtypes and their morphological features.


RESULTS
The constituent ratio of mature and immature types of mast cells in the tissue of oral lichen planus was significantly different from that in the normal tissue (P < 0.01), and such difference was also demonstrated among different types of this malady, including papule-, net- and erosion-type of oral lichen planus (P < 0.05). There was significant difference between the sizes of mature and immature mast cells (P < 0.01) and also the sizes, amount and distribution of the plasma granules within these two mast cells.


CONCLUSIONS
It could be implied that mast cells might play a role in the pathogenesis of oral lichen planus.
Zhang
Ying
Y
College of Stomatology, Medical University of China.
Wang
Zhaoyuan
Z
Yan
Lihua
L
Zhang
Chun
C
D000328:Adult; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D012815:Signal Processing, Computer-Assisted