Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.
Kuo
Reen-Yen
RY
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Wu
Chin-Chung
CC
Chang
Fang-Rong
FR
Yeh
Jwu-Lai
JL
Chen
Ing-Jun
IJ
Wu
Yang-Chang
YC
D018674:Adrenergic Antagonists / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003094:Collagen / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011412:Propanolamines / Q000378:metabolism / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D018674:Adrenergic Antagonists; D001593:Benzyl Compounds; D007546:Isoquinolines; D010975:Platelet Aggregation Inhibitors; D011412:Propanolamines; D011758:Pyrroles; D016718:Arachidonic Acid; D003094:Collagen; D001241:Aspirin; C033394:CGP 12177