Antithyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto's encephalopathy.
Antithyroid antibodies and circulating immune complexes (CIC) were found in the CSF of six patients with Hashimoto's encephalopathy (HE) but not in the CSF of 21 controls. The synthesis of autoantibodies and CIC was intrathecal and their titers were independent of the patients' clinical status or therapy. Their presence in the CSF of patients with acute or subacute encephalopathy may be useful in diagnosing HE.
Ferracci
F
F
Department of Neurology, Ospedale S. Martino, Belluno, Italy. franco.ferracci@ulss.belluno.it
Moretto
G
G
Candeago
R M
RM
Cimini
N
N
Conte
F
F
Gentile
M
M
Papa
N
N
Carnevale
A
A
D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood / Q000134:cerebrospinal fluid; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid*; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D003072:Cognition Disorders / Q000209:etiology; D003221:Confusion / Q000209:etiology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000209:etiology; D020521:Stroke / Q000209:etiology; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies