title: Role of angiotensin in body fluid homeostasis of mice: fluid intake, plasma hormones, and brain Fos.
abstract: CD1 mice injected peripherally with either ANG I or ANG II failed to drink substantial amounts of water or NaCl, yet showed strong Fos immunoreactivity (ir) in subfornical organ (SFO). Mice injected with furosemide showed modest stimulation of NaCl intake either 3 or 24 h later, were hypovolemic, and showed elevated plasma renin activity (PRA). The pattern of Fos-ir in the brain after furosemide was similar to that seen after peripheral injection of ANG II. Mice became hypovolemic after subcutaneous injection of polyethylene glycol (PEG), showed large increases in PRA, aldosterone, and water intake, but did not show sodium appetite. PEG-treated mice had strong activation of SFO as well as other brain regions previously shown to be related to ANG-associated drinking in rats. ANG II appears to have a modified role in the behavioral response to fluid loss in mice compared with rats.
authors.affiliation: University of Florida, Department of Psychology, Gainesville, Florida 32611-2250, USA. nrowland@ufl.edu
authors.forename: Neil E
authors.initials: NE
authors.lastname: Rowland
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Goldstein
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Robertson
mesh_terms: D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D001826:Body Fluids / Q000187:drug effects*; D001834:Body Water / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006400:Hematocrit; D006706:Homeostasis / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011092:Polyethylene Glycols / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage / Q000378:metabolism; D013356:Subfornical Organ / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D006728:Hormones; D016760:Proto-Oncogene Proteins c-fos; D000804:Angiotensin II; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D000450:Aldosterone; D004656:Enalapril; D005665:Furosemide; D000803:Angiotensin I; D012083:Renin