title: Revisiting ethical guidelines for research with terminal wean and brain-dead participants.
abstract: Some research is too risky to be conducted on anyone with a life expectancy of more than a few hours. Yet under some circumstances, the research can still be carried out by using subjects who are either brain dead or are soon to undergo a terminal wean, and who have articulated values that inclusion in the study can honor. So argues a team of ethicists and researchers at M.D. Anderson Cancer Center, where such research was recently undertaken.
authors.forename: Rebecca D
authors.initials: RD
authors.lastname: Pentz
authors.forename: Anne L
authors.initials: AL
authors.lastname: Flamm
authors.forename: Renata
authors.initials: R
authors.lastname: Pasqualini
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Logothetis
authors.forename: Wadih
authors.initials: W
authors.lastname: Arap
mesh_terms: D001926:Brain Death; D032984:Ethics, Research; D017408:Guidelines as Topic; D006805:Human Experimentation / Q000941:ethics*; D006801:Humans; D019452:Terminally Ill; D009927:Tissue and Organ Procurement / Q000941:ethics; D014481:United States; D015300:Ventilator Weaning