Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates.
The authors report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octreotide, to enhance resolution of the fistula. The authors discuss the mechanism of the occurrence of this complication and recommend caution of its use in high-risk premature neonates.
Arevalo
R P
RP
New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA.
Bullabh
P
P
Krauss
A N
AN
Auld
P A M
PA
Spigland
Nitsana
N
D020345:Enterocolitis, Necrotizing / Q000150:complications; D017809:Fatal Outcome; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D000860:Hypoxia / Q000139:chemically induced*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007412:Intestinal Fistula / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use
D005765:Gastrointestinal Agents; D015282:Octreotide