Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis.
We describe the case of a 61-year-old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [(123)I]N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane and single photon emission computed tomography ([(123)I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.
Kim
Joong-Seok
JS
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee
Kwang-Soo
KS
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Han
Si-Ryung
SR
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Chung
Yong-An
YA
Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
D000978:Antiparkinson Agents / Q000627:therapeutic use; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000628:therapy; D007552:Isotonic Solutions / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008875:Middle Aged; D017590:Myelinolysis, Central Pontine / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D009419:Nerve Tissue Proteins; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011485:Protein Binding; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D014326:Tropanes
D000978:Antiparkinson Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D007552:Isotonic Solutions; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D014326:Tropanes; C087210:N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane; D007980:Levodopa