A titanium-catalyzed three-component coupling to generate alpha,beta-unsaturated beta-iminoamines.
The three-component coupling of an amine, alkyne, and isonitrile is facilitated by a titanium complex bearing the N,N-di(pyrrolyl-alpha-methyl)-N-methylamine (dpma) ligand. From this methodology, alpha,beta-unsaturated beta-iminoamines are generated regioselectively with many substrates and are available on multigram scales.
Cao
Changsheng
C
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Shi
Yanhui
Y
Odom
Aaron L
AL