title: [Hypertrophic cardiomyopathy: a rare cause of vascular dementia. A case report].
abstract: Herein, we report a case of a 51 year old man who experienced three ischemic cerebral infarcts in a time of few months. The patient consulted after the third accident. Neurological presentation included pseudobulbar syndrome with a mild cognitive deficit, aphasia, left hemiparesia, hemiasomatognosia and homonymous lateral hemianopsia. Cerebral tomodensitometry and magnetic resonance imaging evidenced large infarcts images involving right middle cerebral artery territory and bilateral borderline zones in the junction of the territories of the middle and posterior cerebral arteries. Ambulatory 24 hours ECG recording (Holter) revealed two hits of non-sustained ventricular tachycardia. Transoesophageal echocardiography conveyed to the diagnosis of hypertrophic cardiomyopathy and displayed the presence of a left auricular thrombus. Anticoagulant therapy and rehabilitation allowed a substantial recovering of the patient's cognitive functions and wasting of the intracardiac thrombus. The clinical features observed in our patient meet the recommended DSM IV diagnosis criteria of vascular dementia, an exceptional complication of HCM. The clinical findings, neuroimagery investigation results, and the chronological link between cerebral attacks and cognitive function deterioration argue for a demential syndrome of vascular origin resulting from multiple embolic infarcts involving medium sized arteries (multi-infarct dementia). The authors emphasize the rarity of such observation. HCM must be considered as a potential cause of embolic stroke and likewise a multi-infarct dementia.
authors.affiliation: Service de Médecine Interne, Hôpital Razi-Manouba, Tunisie.
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Ben Hamouda
authors.forename: Mohamed Néjib
authors.initials: MN
authors.lastname: Tougourti
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hamza
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002545:Brain Ischemia / Q000209:etiology* / Q000473:pathology; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D003072:Cognition Disorders / Q000209:etiology; D015140:Dementia, Vascular / Q000209:etiology* / Q000473:pathology; D004562:Electrocardiography; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013927:Thrombosis; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants