Components of the intracellular cAMP system supporting the olfactory reception of amyl alcohol.
Experiments on isolated frog olfactory epithelium, using vital luminescent microscopy showed that the olfactory transduction of amyl alcohol is mediated by the intracellular cAMP signaling system. Increases in intracellular cAMP levels resulted from activation of adenylate cyclase type III via odorant-induced stimulation of G protein linked to it.
Bigdai
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EV
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
Samoilov
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VO
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D002751:Chlortetracycline / Q000378:metabolism; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D016048:Dideoxyadenosine / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology; D066298:In Vitro Techniques; D015759:Ionomycin / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D009543:Nifedipine / Q000494:pharmacology; D009831:Olfactory Mucosa / Q000187:drug effects* / Q000502:physiology; D000439:Pentanols / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011896:Rana temporaria; D011930:Reaction Time; D015398:Signal Transduction; D012903:Smell
D017607:Aluminum Compounds; D000963:Antimetabolites; D002121:Calcium Channel Blockers; D002614:Chelating Agents; D007476:Ionophores; D000439:Pentanols; D010726:Phosphodiesterase Inhibitors; D005576:Colforsin; C050992:tetrafluoroaluminate; D002110:Caffeine; D016048:Dideoxyadenosine; D004533:Egtazic Acid; D015759:Ionomycin; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D009543:Nifedipine; D002122:Calcium Chloride; D005459:Fluorides; D002751:Chlortetracycline