[Central nervous system vasculitis and of the peripheral nerves in the elderly].
Vasculitis of the nervous system are rare in the elderly. When present, they may constitute an urgent diagnosis and a therapeutic emergency. Clinical expression is rich and without specificity. Atypical signs (unusual course of dementia, systemic signs) or atypical laboratory results (inflammatory syndrome) may suggest the diagnosis of vasculitis. However, as multiple comorbidity is the rule in elderly subjects, searching for intercurrent factors (e.g. atrial fibrilation due to infectious disease causing embolic stroke) may be more contributive than searching for proof of a rare disease (vasculitis) with invasive procedures in this population. Giant cell (temporal) arteritis is the only vasculitis specifically related with age; the vital prognosis of vision may be compromised. Corticosterid therapy must be instituted without delay. Periartritis nodosa begins in 30% of cases after 60 years of age. The clinical features are the same as in younger subjects. Other vasculidis are rare in the elderly. In absence of specific studies in this population, therapeutic protocols are the same as in younger subjects but may have to be adjusted.
Boddaert
Jacques
J
Centre de Gériatrie, Pavillon M.-Bottard, Hôpital de La Pitié-Salpêtrière (AP-HP), 47-83, boulevard de l'Hôpital, 75651 Paris Cedex 13.
Verny
Marc
M
D000368:Aged; D013700:Giant Cell Arteritis / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000209:etiology / Q000628:therapy