title: Acute myocardial infarction after bone marrow transplantation: an unsuspected late complication.
abstract: Acute myocardial infarction is a common disease rarely seen as a complication of bone marrow transplantation in young patients. We report on a 25-year-old patient 3.5 years after bone marrow transplantation who suffered an acute anterior wall myocardial infarction complicated by cardiogenic shock. The patient was treated with thrombolysis and emergent coronary angioplasty but died a few hours following admission. We suggest that the combination of low-dose chest irradiation and prolonged immunosuppression with graft-versus-host disease contributed to the development of the coronary artery disease in this patient. Though rarely encountered, physicians caring for young patients after bone marrow transplantation should be aware of potential ischemic complications.
authors.affiliation: Department of Internal Medicine, Hadassah University Hospital Mount Scopus, Hadassah-Hebrew University Medical School, Jerusalem, Israel. mooshie@netvision.net.il.|Hematology Unit, Hadassah University Hospital Mount Scopus, Hadassah-Hebrew University Medical School, POB 24035, 91240, Jerusalem, Israel. mooshie@netvision.net.il.
authors.forename: M E
authors.initials: ME
authors.lastname: Gatt
authors.affiliation: Hematology Unit, Hadassah University Hospital Mount Scopus, Hadassah-Hebrew University Medical School, POB 24035, 91240, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Liebster
authors.affiliation: Department of Internal Medicine, Hadassah University Hospital Mount Scopus, Hadassah-Hebrew University Medical School, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Leibowitz
authors.affiliation: Hematology Unit, Hadassah University Hospital Mount Scopus, Hadassah-Hebrew University Medical School, POB 24035, 91240, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Matzner
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000628:therapy; D009203:Myocardial Infarction / Q000209:etiology*; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects