title: [Effects of exogenous IL-10 on IL-6 and ICAM-1 expression in inflammatory gingival tissue].
abstract: OBJECTIVE
  This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.
  
  
  METHODS
  The expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.
  
  
  RESULTS
  IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.
  
  
  CONCLUSIONS
  The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.
authors.affiliation: College of Stomatology, Shandong University.
authors.forename: Pishan
authors.initials: P
authors.lastname: Yang
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Qi
authors.forename: Shaohua
authors.initials: S
authors.lastname: Ge
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000328:Adult; D015536:Down-Regulation; D005260:Female; D005881:Gingiva / Q000378:metabolism; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D016753:Interleukin-10 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged
chemical_list: D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10