title: [Crohn's disease in children].
abstract: Crohn's disease is a chronic transmural inflammation that can involve any part of the digestive system, from the oral cavity to the anal canal, being combined with many abenteric manifestations. It can appear at any age. The first description of this disease in a teenager was made in 1834 by B.B. Crohn, and 11 years later a series of observations describing 48 children with this disease was published. The concept of the Crohn's disease as a non-children illness underwent a change with the widening of diagnostic possibilities, wide use of the endoscopic method of diagnostics in pediatric practice, and histological studies of biopsy materials. A steady growth of the frequency of Crohn's disease detections has been recorded since the middle of the 1980s. Morbidity in Great Britain and Sweden doubled reaching 3.1 for 100,000 infants, and in 1993 its spread made up 16.6 for 100,000.
authors.affiliation: Central Scientific Research Institute of Gastroenterology, Moscow.
authors.forename: V G
authors.initials: VG
authors.lastname: Rumiantsev
authors.forename: N E
authors.initials: NE
authors.lastname: Shchigoleva
mesh_terms: D002648:Child; D003424:Crohn Disease; D006801:Humans; D019804:Mesalamine / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use
chemical_list: D012460:Sulfasalazine; D019804:Mesalamine