Ongoing right ventricular hemodynamics in heart failure: clinical value of measurements derived from an implantable monitoring system.
OBJECTIVE
This study examined the characteristics of continuously measured right ventricular (RV) hemodynamic information derived from an implantable hemodynamic monitor (IHM) in heart failure patients.


BACKGROUND
Hemodynamic monitoring might improve the day-to-day management of patients with chronic heart failure (CHF). Little is known about the characteristics of long-term hemodynamic information in patients with CHF or how such information relates to meaningful clinical events.


METHODS
Thirty-two patients with CHF received a permanent RV IHM system similar to a single-lead pacemaker. Right ventricular systolic and diastolic pressures, heart rate, and pressure derivatives were continuously measured for nine months without using the data for clinical decision-making or management of patients. Data were then made available to clinical providers, and the patients were followed up for 17 months. Pressure characteristics during optimal volume, clinically determined volume-overload exacerbations, and volume depletion events were examined. The effect of IHM on hospitalizations was examined using the patients' historical controls.


RESULTS
Long-term RV pressure measurements had either marked variability or minimal time-related changes. During 36 volume-overload events, RV systolic pressures increased by 25 +/- 4% (p < 0.05) and heart rate increased by 11 +/- 2% (p < 0.05). Pressure increases occurred in 9 of 12 events 4 +/- 2 days before the exacerbations requiring hospitalization. Hospitalizations before using IHM data for clinical management averaged 1.08 per patient year and decreased to 0.47 per patient-year (57% reduction, p < 0.01) after hemodynamic data were used.


CONCLUSIONS
Long-term ambulatory pressure measurements from an IHM may be helpful in guiding day-to-day clinical management, with a potentially favorable impact on CHF hospitalizations.
Adamson
Philip B
PB
Department of Internal Medicine/Cardiology, University of Oklahoma Health Sciences Center, PO Box 26901, WP3120, Oklahoma City, OK 73190, USA. philip-adamson@ouhsc.edu
Magalski
Anthony
A
Braunschweig
Frieder
F
Böhm
Michael
M
Reynolds
Dwight
D
Steinhaus
David
D
Luby
Allyson
A
Linde
Cecilia
C
Ryden
Lars
L
Cremers
Bodo
B
Takle
Teri
T
Bennett
Tom
T
D000328:Adult; D000368:Aged; D015716:Electrocardiography, Ambulatory / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D018497:Ventricular Dysfunction, Right / Q000209:etiology* / Q000503:physiopathology*