Development and regression of non-capillary vessels in the bovine corpus luteum.
The corpus luteum life cycle is accompanied by capillary growth, maturation and degeneration. Arterial blood vessels are thought to undergo hyperplasia and hypertrophy during the stage of regression, as is the case with non-capillary vessels. In this study, we used morphological studies to show that the development of non-capillary vessels occurs at other corpus luteum stages. Non-capillary vessels were present at the developmental stage of the corpus luteum, and increased markedly in number in the subsequent stages. After double-staining for ASM-1 actin and Ki-67 nuclear antigen, the proliferation of smooth muscle cells (SMCs) was only detected during stages of development and secretion. When the capillaries had disappeared at the regression stage, the arterial blood-vessel walls thickened noticeably. This was attributed to the development of fibroelastosis as shown by staining for collagenous and elastic fibres. In conclusion, the bovine corpus luteum represents a physiological model for studying arteriolization at all stages of development and secretion. At the regression stage, arterioregression sets in.
Bauer
M
M
Department of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, Germany. baum@medizin.uni-leipzig.de
Schilling
N
N
Spanel-Borowski
K
K
D000818:Animals; D002196:Capillaries / Q000166:cytology; D002417:Cattle; D003338:Corpus Luteum / Q000098:blood supply / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology; D004971:Estrus / Q000502:physiology*; D005260:Female; D003341:Luteolysis / Q000502:physiology*; D009130:Muscle, Smooth / Q000166:cytology