[Effects of nimodipine on cochlear blood flow with normal and vertebrobasilar insufficiency status].
OBJECTIVE
To study effect of nimodipine (ND) on cochlear blood flow (CBF).


METHODS
CBF was measured in twenty-two guinea pigs by laser Doppler flowmetry(LDF).


RESULTS
Nimodipine decreased CBF following the decrease of systemic BP and present a dose dependent mode, neither the dose of nimodipine is lower, normal and higher, nor the animal is under the status of normal supply of inner ear blood flow and ischemia of inner ear caused by vertebrobasilar insufficiency(VBI).


CONCLUSIONS
It suggested that this compound may be of little clinical use to elevate CBF.
Ma
Furong
F
Department of Otolaryngology, Third Hospital of Beijing University, Beijing 100083.
Li
Xuepei
X
Zhao
Yimin
Y
Zhong
Zhen
Z
Gu
Yalan
Y
Yan
Jinhua
J
D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009553:Nimodipine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014715:Vertebrobasilar Insufficiency / Q000188:drug therapy*
D009553:Nimodipine