title: Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen: a human histologic report.
abstract: This study evaluated the clinical, radiographic, and histologic response to Bio-Oss Collagen when used alone or in combination with Bio-Gide bilayer collagen membrane for the treatment of four intrabony defects (5 to 7 mm) around single-rooted teeth. After reflecting a full-thickness flap, thorough degranulation and root planing were accomplished. In all cases, Bio-Oss Collagen was then used to fill the defects, and in two cases, a Bio-Gide membrane was placed over the filled defect. Radiographs, clinical probing depths, and attachment levels were obtained before treatment and immediately preceding en bloc resection of teeth and surrounding tissues 9 months later. Reduction in pocket depth and gain in clinical attachment level were observed for both treatment protocols. The histologic evaluation demonstrated the formation of a complete new attachment apparatus, evidencing periodontal regeneration that varied with defect morphology. This human histologic study demonstrated that Bio-Oss Collagen has the capacity to induce regeneration of the periodontal attachment apparatus when placed in intrabony defects.
authors.affiliation: Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Camelo
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Lynch
authors.forename: Robert K
authors.initials: RK
authors.lastname: Schenk
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D001672:Biocompatible Materials / Q000627:therapeutic use; D001857:Bone Matrix / Q000473:pathology / Q000637:transplantation*; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D003739:Dental Cementum / Q000473:pathology; D004846:Epithelial Attachment / Q000473:pathology; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D010012:Osteogenesis / Q000502:physiology; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D012038:Regeneration / Q000502:physiology; D016745:Root Planing; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen