Modeling of prebiotic catalysis with adenylated polymeric templates: crystal structure studies and kinetic characterization of template-assisted phosphate ester hydrolysis.
We have synthesized and characterized novel, copper-metalated, polymeric templates that contain adenine nucleobases. These promote hydrolysis of non-natural and natural phosphate ester substrates in a highly efficient and catalytic fashion. The crystal structure of the cooper-containing adenylated monomer reveals the formation of a polymeric array, through coordination to both N1 and N7 atoms. Possible implications of these studies for prebiotic catalysis, involving synergism between adenine and copper ions, are also discussed.
Srivatsan
S G
SG
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016, UP, India.
Parvez
Masood
M
Verma
Sandeep
S
D000225:Adenine / Q000737:chemistry*; D000227:Adenine Nucleotides / Q000378:metabolism; D001704:Biopolymers / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003300:Copper / Q000378:metabolism; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D013698:Templates, Genetic; D014638:Vanadates / Q000378:metabolism
D000227:Adenine Nucleotides; D001704:Biopolymers; D004952:Esters; D014638:Vanadates; C010565:2',3'-cyclic AMP; D003300:Copper; D000225:Adenine