Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil.
The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV), simian type D retrovirus (SRV), cercopithecine herpesvirus type-1 (B virus), rhesus cytomegalovirus (RhCMV), measles virus (MV), and hepatitis A virus (HAV). All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group.
Andrade
Marcia Ribeiro
MR
Oswaldo Cruz Foundation, Centro de Criação de Animais de Loboratório, Rio de Janeiro, Brazil. andrade@cecal.fiocruz.br
Yee
Joann
J
Barry
Peter
P
Spinner
Abigail
A
Roberts
Jeffrey A
JA
Cabello
Pedro H
PH
Leite
Jose Paulo
JP
Lerche
Nicholas W
NW
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D030121:Betaretrovirus / Q000302:isolation & purification; D001938:Brazil / Q000453:epidemiology; D003587:Cytomegalovirus / Q000302:isolation & purification; D005260:Female; D030041:Hepatitis A virus / Q000302:isolation & purification; D006568:Herpesvirus 1, Cercopithecine / Q000302:isolation & purification; D008252:Macaca fascicularis / Q000821:virology*; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology*; D008297:Male; D008459:Measles virus / Q000302:isolation & purification; D008992:Monkey Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D016036:Seroepidemiologic Studies; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification; D015303:Simian T-lymphotropic virus 1 / Q000302:isolation & purification
D000914:Antibodies, Viral