title: The role of muscle flaps in pulmonary aspergillosis.
abstract: Pulmonary invades the lung parenchyma and vessels, causing necrotizing pneumonia and massive hemoptysis in immunocompromised patients. Medical treatment alone often fails to clear the organism. Early surgical intervention is advocated in localized disease to remove infection near pulmonary vessels. The resection is limited in an attempt to preserve as much lung function as possible. However, preexisting cavitations and lung disease predispose to postoperative space problems, including prolonged air leak, bronchopleural fistula, and empyema. Muscle flaps provide a solution to these problems by obliterating residual space and providing protective coverage to the bronchial stump. The authors present four cases of pulmonary aspergillosis treated by multimodality therapy and extrathoracic muscle flap transposition. Factors that may contribute to successful treatment include underlying condition of the host and history of cancer, radiation therapy, and great vessel involvement. Despite aggressive medical and surgical therapy, pulmonary aspergillosis has a poor prognosis.
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Colwell
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Mentzer
authors.forename: Sara O
authors.initials: SO
authors.lastname: Vargas
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Orgill
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000601:surgery*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013524:Surgical Flaps