title: Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives.
abstract: A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-[4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene]thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.
authors.affiliation: New Drug Research Laboratories, Chong Kun Dang Research Institute, Cheonan, South Korea.
authors.forename: Bok Young
authors.initials: BY
authors.lastname: Kim
authors.forename: Joong Bok
authors.initials: JB
authors.lastname: Ahn
authors.forename: Hong Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Kyoung Sik
authors.initials: KS
authors.lastname: Moon
authors.forename: Tae Bo
authors.initials: TB
authors.lastname: Sim
authors.forename: Jae Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Soon Kil
authors.initials: SK
authors.lastname: Ahn
authors.forename: Chung Il
authors.initials: CI
authors.lastname: Hong
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012266:Ribose / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013780:Tetroses / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D045162:Thiazolidinediones
chemical_list: D007004:Hypoglycemic Agents; D011759:Pyrrolidines; D013780:Tetroses; D013844:Thiazoles; D045162:Thiazolidinediones; D012266:Ribose; C089946:2,4-thiazolidinedione; C032519:pyrrolidine; C073321:erythrose