title: Worth continuing doing ex situ liver graft splitting? A single-center analysis.
abstract: Grafts for split liver transplantation can be prepared in situ during the retrieval operation, or ex situ on the back table. The in situ technique has theoretical advantages because it minimizes the cold ischemic time and allows excellent hemostasis at the cut surface. However, in situ liver division prolongs the retrieval procedure, may precipitate hemodynamic instability in the donor, and may cause logistical difficulties for some centers. This report is a single-center analysis comparing results of ex situ liver division (group I: 1992-97; and group II: 1998-2001) before and after a new protocol for liver graft division was introduced in our center. Eighty-nine split liver transplants (SLT) were reviewed retrospectively. Vascular complications were less common in group II (3.3% vs. 20%; p = 0.04), and 1-year graft survival increased from 59% to 78% (p = 0.03). Since 1998, 1-year graft survival of SLT has been similar to that of conventional liver graft transplantation in our center (78% and 74%, respectively). In conclusion, good results can be achieved from splitting livers ex situ and this procedure should be considered when the in situ technique is not feasible.
authors.affiliation: Liver Unit Birmingham Children's Hospital, Birmingham, UK.
authors.forename: Huda M
authors.initials: HM
authors.lastname: Noujaim
authors.forename: Bridget
authors.initials: B
authors.lastname: Gunson
authors.forename: David A
authors.initials: DA
authors.lastname: Mayer
authors.forename: Darius F
authors.initials: DF
authors.lastname: Mirza
authors.forename: John A C
authors.initials: JA
authors.lastname: Buckels
authors.forename: Daniel
authors.initials: D
authors.lastname: Candinas
authors.forename: Paul
authors.initials: P
authors.lastname: McMaster
authors.forename: Jean
authors.initials: J
authors.lastname: de Ville de Goyet
mesh_terms: D000293:Adolescent; D000328:Adult; D001652:Bile Ducts / Q000473:pathology; D002648:Child; D006085:Graft Survival; D006499:Hepatic Artery / Q000473:pathology; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007511:Ischemia; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology; D013997:Time Factors; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome