Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.
The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.
Mori
Yoki
Y
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan. mori@hoku-iryo-u.ac.jp
Kamata
Kazuyuki
K
Toda
Noriko
N
Hayashi
Hideyuki
H
Seki
Koh-ichi
K
Taneda
Shinji
S
Yoshino
Shin
S
Sakushima
Akiyo
A
Sakata
Masakatsu
M
Suzuki
Akira K
AK
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001158:Arteries / Q000187:drug effects; D007551:Isotonic Contraction / Q000187:drug effects; D009596:Nitrophenols / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D014664:Vasodilation / Q000187:drug effects*; D001335:Vehicle Emissions / Q000633:toxicity*
D000393:Air Pollutants; D009596:Nitrophenols; D001335:Vehicle Emissions