title: [A case of multicentric Castleman's disease with multiple pulmonary nodules].
abstract: A 55-year-old woman visited our hospital for further examination of abnormal shadows on chest radiographs. Her routine chest radiograph showed two nodular shadows in the right lower lung field. A chest CT scan revealed other nodules, small patchy shadows in both lung fields, and enlargement of the mediastinal lymphnodes (#2, 3). Laboratory data showed polyclonal hyperimmunoglobulinemia. This case was initially considered on the basis of a transbronchial lung biopsy to be a plasma cell granuloma. However, serum gammaglobulin levels gradually increased, and video-assisted thoracoscopic surgery was performed to aid in making a definite diagnosis. Biopsy specimens revealed lymphoid follicles with plasma cells which were stained with both anti-kappa chain and anti-lambda chain antibodies. The patient was treated with prednisolone (50 mg/day), and the serum gammaglobulin level and the shadows on the chest CT were temporarily slightly improved. During the clinical course, her laboratory data and histological specimens were re-examined, and the final diagnosis was multicentric Castleman's disease.
authors.affiliation: Department of Respiratory Medicine, Kochi Municipal Hospital, Kochi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Doi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Keiko
authors.initials: K
authors.lastname: Satoh
authors.forename: Kenya
authors.initials: K
authors.lastname: Sumitomo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawano
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Tatsumi
mesh_terms: D005871:Castleman Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed