title: Simultaneous surgical treatment of abdominal aortic aneurysm and carcinoma of the bladder.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the short-term and long-term results of simultaneous surgical treatment of coexisting abdominal aortic aneurysm and bladder carcinoma.
  
  
  METHODS
  A prospective study was carried out to compare patients undergoing simultaneous surgical treatment of abdominal aneurysm and bladder carcinoma with control patients undergoing surgery for either one of the two diseases alone. From January 1995 to December 2000, 16 consecutive patients were seen with concomitant abdominal aortic aneurysm and bladder carcinoma at our institutional referral center. All patients underwent a standard operative protocol that included aneurysm graft replacement, radical cystoprostatectomy, and urinary reconstruction. Endovascular treatment of the aneurysm was considered in the last 2 years of the study. After each simultaneous treatment case, two control patients were selected according to the same type of vascular or urinary procedure, respectively, and pathologic staging. The analyzed endpoint was mortality, and confounder variables included common and disease-specific risk factors. Frequencies of vascular, urologic, and systemic complications were carefully considered with special attention to graft infection and tumor recurrence.
  
  
  RESULTS
  Endovascular treatment was not performed for morphologic reasons. No perioperative mortality was observed. A trend toward inferior survival rates in simultaneously treated patients was observed in the early follow-up period, but survival analysis with log-rank test showed no statistical difference among the groups (P =.19). Cox proportional hazard model results proved no influence of the different group treatments on survival (P =.49) and no influence of age and risk factors, except for preoperative renal status (P =.015). The increased mortality rate of the simultaneous treatment group could be ascribed to the presence of preoperative moderate renal insufficiency in two study group patients. Long-term survival of treated patients is mainly dependent on cancer progression. Graft infection and other vascular complications were not observed. Systemic and urologic complications were similar in study and control groups.
  
  
  CONCLUSIONS
  This study shows that the simultaneous surgical approach to coexisting abdominal aortic aneurysm and transitional cell carcinoma of the bladder represents a suitable choice of treatment in highly specialized centers, but patients with preoperative renal insufficiency should be carefully evaluated. Endovascular treatment represents an appealing alternative whenever indicated.
authors.affiliation: Division of Vascular Surgery, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Grego
authors.forename: Sandro
authors.initials: S
authors.lastname: Lepidi
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Bassi
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Tavolini
authors.forename: Franco
authors.initials: F
authors.lastname: Noventa
authors.forename: Francesco
authors.initials: F
authors.lastname: Pagano
authors.forename: Giovanni P
authors.initials: GP
authors.lastname: Deriu
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000601:surgery*; D015653:Cystectomy; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D011468:Prostatectomy; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000601:surgery*; D014547:Urinary Diversion