title: The same endothelial receptor controls lymphocyte traffic both in vascular and lymphatic vessels.
abstract: The mechanisms controlling the exit of lymphocytes from tissues via lymphatics are practically unknown. We have now identified a 270-300-kDa molecule designated common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1) on human lymphatic endothelium and high endothelial venules. We show that it mediates binding of lymphocytes both to high endothelial venules and to lymphatic vessels. Moreover, blocking of the function of CLEVER-1 results in significant reduction of lymphocyte traffic in vivo. Notably, CLEVER-1 is also an inducible vascular adhesion molecule for other classes of leukocytes at sites of inflammation in peripheral tissues. These findings suggest that CLEVER-1 is involved in regulation of lymphocyte recirculation and migration of leukocytes to sites of inflammation and is a potential new target to control inflammation.
authors.affiliation: MediCity Research Laboratory, Department of Medical Microbiology, University of Turku, Tykistökatu 6A, 20520 Turku, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Irjala
authors.forename: Kati
authors.initials: K
authors.lastname: Elima
authors.forename: Eva-Liz
authors.initials: EL
authors.lastname: Johansson
authors.forename: Marika
authors.initials: M
authors.lastname: Merinen
authors.forename: Keiju
authors.initials: K
authors.lastname: Kontula
authors.forename: Kalle
authors.initials: K
authors.lastname: Alanen
authors.forename: Reidar
authors.initials: R
authors.lastname: Grenman
authors.forename: Marko
authors.initials: M
authors.lastname: Salmi
authors.forename: Sirpa
authors.initials: S
authors.lastname: Jalkanen
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D004729:Endothelium, Lymphatic / Q000737:chemistry* / Q000166:cytology; D004730:Endothelium, Vascular / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000032:analysis / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D011817:Rabbits
chemical_list: D008562:Membrane Glycoproteins