[Acute aging model induced by gamma-ray irradiation].
In order to develop a quick and convenient model of acute induced-aging, gamma-ray (3.0 Gy/time for 4 min 53 s for 5 days) is used to irradiate a group of rats, and galactose (40 mg.kg-1.d-1 for 40 days) is injected into a group of mice. At the end of the experiment, the activities of superoxide dismutase (SOD) and content of malondiadehycle (MDA) in the serum of experimental animals are assayed, showing that the gamma-ray irradiation leads to the reduction of SOD activity and an increase in MDA content in the serum of the rats, while galactose injection leas to the reduction of SOD activity and an increase in MDA content in the serum of the mice. The results from this investigation indicate that an acute aging model can be induced by gamma-ray irradiating on rats.
Li
Yun
Y
School of Public Health, West China University of Medical Sciences, Chengdu 610041, China.
Yang
Suqing
S
Zhang
Jun
J
D000375:Aging / Q000097:blood / Q000528:radiation effects*; D000818:Animals; D004195:Disease Models, Animal; D005720:Gamma Rays; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood*; D014916:Whole-Body Irradiation
D008315:Malondialdehyde; D013482:Superoxide Dismutase