Iris color and intraocular pressure: the Blue Mountains Eye Study.
OBJECTIVE
To assess the relationship between iris color and intraocular pressure (IOP).


METHODS
Population-based, cross-sectional study.


METHODS
The Blue Mountains Eye Study examined 3,654 largely Caucasian participants, aged 49 to 97 years, from 1992 to 1994. Information was collected about glaucoma risk factors, and Goldmann applanation IOP measurements were taken. Iris color was assessed by comparing the undilated appearance of each eye with three standard photographs. Participants who had previous cataract or glaucoma surgery and those using glaucoma medications were excluded.


RESULTS
Mean IOP measurements increased with increasing grades of iris pigmentation. After simultaneous adjustment for variables associated with IOP, mean measurements were 15.92 mm Hg for blue iris color, 16.04 mm Hg for hazel or green, 16.11 mm Hg for tan-brown, and 16.49 mm Hg for dark brown (P for trend = .001).


CONCLUSIONS
This study demonstrates a modest but statistically significant association between increasing iris color and IOP.
Mitchell
Robert
R
Christchurch School of Medicine, University of Otago, Christchurch, New Zealand.
Rochtchina
Elena
E
Lee
Anne
A
Wang
Jie Jin
JJ
Mitchell
Paul
P
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005127:Eye Color / Q000502:physiology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007498:Iris / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009517:New South Wales; D014065:Tonometry, Ocular