Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study.
The nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) may play a role in prostate carcinogenesis. We examined the association between the PPAR-gamma Pro12Ala polymorphism and prostate cancer risk in a cohort of Finnish male smokers. In a nested case-control analysis that included 193 prostate cancer cases and 188 matched controls, we found no significant association between this polymorphism and prostate cancer risk (odds ratio, OR=1.27, 95% confidence interval, CI: 0.83-1.94), or significant trend or association with tumor stage (OR=1.28, 95% CI: 0.54-3.04 for metastatic disease) or grade (OR=1.57, 95% CI: 0.63-3.91 for poorly differentiated disease). The Pro12Ala polymorphism does not appear to play a significant role in prostate cancer risk in this cohort of men.
Paltoo
Dina
D
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Suite 705, MSC 8314, Bethesda, MD 20892-7058, USA. paltoodi@mail.nih.gov
Woodson
Karen
K
Taylor
Philip
P
Albanes
Demetrius
D
Virtamo
Jarmo
J
Tangrea
Joseph
J
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D000368:Aged; D019943:Amino Acid Substitution; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002454:Cell Differentiation; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005387:Finland / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000502:physiology; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D024502:alpha-Tocopherol / Q000627:therapeutic use; D019207:beta Carotene / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D019207:beta Carotene; D024502:alpha-Tocopherol