title: A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids.
abstract: A facile and convenient approach to 17-ketosteroids is described. Treatment of steroids containing the C-17-dihydroxy acetone side chain with an excess of sodium methoxide in dry 1,4-dioxane under reflux, affords high yields of the corresponding 17-ketosteroids that are recovered as pure products, without the need of further purification.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi della Calabria, Via P. Bucci, Cubo 15/C, I-87036 Arcavacata di Rende (CS), Italy.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Le Pera
authors.forename: Antonella
authors.initials: A
authors.lastname: Leggio
authors.forename: Carlo
authors.initials: C
authors.lastname: Siciliano
authors.forename: Maria L
authors.initials: ML
authors.lastname: Di Gioia
authors.forename: Anna
authors.initials: A
authors.lastname: Napoli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sindona
authors.forename: Angelo
authors.initials: A
authors.lastname: Liguori
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000737:chemistry*; D015068:17-Ketosteroids / Q000138:chemical synthesis* / Q000737:chemistry; D000096:Acetone / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000096:Acetone