Oxytocin and prostaglandins F2alpha and E2 do not enhance HIV antigen production in vitro.
Oxytocin and prostaglandins (PGs) are hormones involved in labor and are used clinically for its induction. In this study the effect of oxytocin, PGF(2alpha), and PGE(2) on Humour immunodeficiency virus-1 production in acutely and persistently infected cells was measured. No significant effect on p24 antigen production was found with oxytocin or PGs, except for a transient decrease in persistently infected cells treated with 1 micro M PGF(2alpha). These results showed that oxytocin and PGs could be used clinically for labor induction without any direct enhancement in viral production. Besides, the results with PGF(2alpha) at the highest concentration studied may indicate a pharmacological effect.
Ceballos
A
A
National Reference Center for AIDS, Department of Microbiology, University of Buenos Aires, School of Medicine, Buenos Aires, Argentina. aceballo@fmed.uba.ar
Rabinovich
R D
RD
Marquina
S
S
Fernández Larrosa
P N
PN
Martinez Peralta
L
L
D002460:Cell Line; D002478:Cells, Cultured; D015237:Dinoprost / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D016655:HIV Core Protein p24 / Q000096:biosynthesis* / Q000187:drug effects*; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D010121:Oxytocin / Q000494:pharmacology*
D016655:HIV Core Protein p24; D010121:Oxytocin; D015237:Dinoprost; D015232:Dinoprostone