title: Enforced proximity in the function of a famous scaffold.
abstract: Recent studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the fundamental importance of proximity in enzyme regulation and of keeping a proper distance for maintaining signaling specificity.
authors.affiliation: Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Ferrell
authors.forename: Karlene A
authors.initials: KA
authors.lastname: Cimprich
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D005800:Genes, Fungal; D008954:Models, Biological; D009154:Mutation; D015202:Protein Engineering; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C080321:STE5 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins