Antibiotic treatment of incipient drug-induced gingival overgrowth in adult renal transplant patients.
BACKGROUND
Drug-induced gingival overgrowth (GO) remains a challenge in periodontics. Partial and total regressions of this GO have been reported after a short course of antibiotics.


METHODS
We conducted a double-blinded controlled randomised study to determine the effect of metronidazole (MNZ) or azithromycin (AZM) on the regression of incipient cyclosporin A-induced GO in 40 adult renal transplanted patients. The quantitation of the GO was performed with Image Digital Analysis.


RESULTS
None of the patients with GO showed complete remission after 30 days. The pretreatment GO index was 0.895 +/- 0.16 in the metronidazole treatment group (MNZ group, n = 13), 0.932 +/- 0.11 in the azithromycin treatment group (AZM group, n = 14), and 1.073 +/- 0.32 in the controls (placebo group, n = 13). At the end of the study (30 days), the GO index score was lower in 54.4% and 62.3% of the MNZ and AZM groups, respectively, and the mean score differences were statistically significant between the groups (0.897 +/- 0.28, MNZ group vs. 0.909 +/- 0.15, AZM group vs. 1.130 +/- 0.3, placebo group, P < 0.05 ANOVA).


CONCLUSIONS
A 7-day course of MNZ or AZM does not induce remission of CsA-induced GO, although it acts on concomitant bacterial over-infection and gingival inflammation.
Mesa
F L
FL
Department of Periodontics, School of Dentistry, University of Granada, Granada, Spain.
Osuna
A
A
Aneiros
J
J
Gonzalez-Jaranay
M
M
Bravo
J
J
Junco
P
P
Del Moral
R G
RG
O'Valle
F
F
D000328:Adult; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D016572:Cyclosporine / Q000009:adverse effects; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D019214:Gingival Overgrowth / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D010512:Periodontal Index; D010919:Placebos; D012074:Remission Induction; D018709:Statistics, Nonparametric
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents; D010919:Placebos; D008795:Metronidazole; D017963:Azithromycin; D016572:Cyclosporine