[Hemostimulating properties of cropanol during cytostatics-induced myelosuppression].
The granulocyte lineage reaction and its mechanism were studied in the bone marrow of patients with breast cancer in stage III-IV treated according to a specific CAF scheme including cropanol, an antitumor drug of the animal origin. It was found that the bone marrow cytopoiesis suppressed by the cytostatics is stimulated by cropanol on the level of committed precursors, morphologically differentiated bone marrow elements, and peripheral blood.
Zhdanov
V V
VV
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Gol'dberg
V E
VE
Khrichkova
T Iu
TIu
Matiash
M G
MG
Gur'iantseva
L A
LA
Simolina
E I
EI
Vysotskaia
V V
VV
Suslov
N I
NI
Popova
N O
NO
Dygaĭ
A M
AM
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001685:Biological Factors / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D023461:Myeloid Progenitor Cells / Q000187:drug effects / Q000473:pathology
D001685:Biological Factors; C404022:pantohematogen; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil