title: Dynamic three-dimensional MR renography for the measurement of single kidney function: initial experience.
abstract: A three-dimensional magnetic resonance (MR) renographic method to measure single kidney glomerular filtration rate (GFR) and split renal function was developed that is based on renal signal intensity measurements during 2-3 minutes after intravenous injection of a low dose (2 mL or 0.01 mmol/kg) of gadopentetate dimeglumine. In nine subjects, single kidney MR GFR indices correlated well with technetium 99m (99mTc) diethylenetriaminepentaacetic acid (DTPA) clearance (r = 0.7-0.8) for GFR values of 7-48 mL/min. MR right kidney split renal function values (range, 32%-59%) also correlated well with 99mTc-DTPA radionuclide measurements (r = 0.76); differences between the two methods averaged 0.8% +/- 8. MR renography was performed along with contrast material-enhanced MR imaging of the kidneys and renal arteries and added 8 minutes or less to the total examination time.
authors.affiliation: Department of Radiology-MRI, New York University Medical Center, 530 First Ave, HCC Basement, New York, NY 10016, USA. vivian.lee@med.nyu.edu
authors.forename: Vivian S
authors.initials: VS
authors.lastname: Lee
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.forename: Marilyn E
authors.initials: ME
authors.lastname: Noz
authors.forename: Peter
authors.initials: P
authors.lastname: Lee
authors.forename: Meera
authors.initials: M
authors.lastname: Raghavan
authors.forename: Elissa L
authors.initials: EL
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D021621:Imaging, Three-Dimensional; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate