title: Feasibility of sentinel lymph node radiolocalization in neck node-negative oral squamous cell carcinoma patients.
abstract: We examined the reliability of the use of lymphoscintigraphy (LS) and a hand-held gamma probe (GP) to identify the sentinel lymph node (SLN), and sequentially determined the feasibility of SLN radiolocalization in clinical neck node-negative oral squamous cell carcinoma (SCC) patients. A radiolabel with the unfiltered (99m)Tc tin colloid was injected submucosally around the primary site followed by LS at 2-hour intervals. Preoperative localization was performed with GP. After en bloc removal of the regional lymphatics, histopathologic results for the nodes were compared with the SLN radiolocalization. The LS and GP counts were well correlated, and there was concordance between SLN and neck node status in 7 of 8 cases (87.5%). We thus considered that our concept in this study was valid in determining the necessity for neck dissection for those node-negative oral SCC patients.
authors.affiliation: Department of Otolaryngology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. sukohno@kyorin-u.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kohno
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohno
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kihara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitahara
authors.forename: Etsuyo
authors.initials: E
authors.lastname: Tamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanabe
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kosuda
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D014055:Tomography, Emission-Computed / Q000379:methods*