A case of chronic myeloid leukemia complicated with minimal change nephrotic syndrome.
We present a 28-year-old patient with chronic myeloid leukemia (CML) in chronic phase complicated with nephrotic syndrome. The bone marrow cells revealed the presence of Philadelphia chromosome, the cytogenetic hallmark of CML, that results from a balanced, reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11). This reciprocal translocation leads to the formation of the BCR/ABL fusion gene, the presence of which was confirmed using the highly sensitive fluorescence in situ hybridization technique. The renal biopsy was compatible with minimal change nephrotic syndrome. To the best of our knowledge, this is the first case of minimal change nephrotic syndrome associated with CML before the administration of any therapy.
Talwar
Rashmi
R
Department of Anatomy, All-India Institute of Medical Sciences, New Delhi, India.
Dash
S C
SC
Kucheria
Kiran
K
D000328:Adult; D001706:Biopsy; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007668:Kidney / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000175:diagnosis; D011507:Proteinuria; D014178:Translocation, Genetic; D014463:Ultrasonography
D016044:Fusion Proteins, bcr-abl