title: [Experimental study of the effect of glucosamine hydrochloride on metabolic and repair processes in connective tissue structures].
abstract: The effects of glucosamine hydrochloride on the metabolic and repair processes were studied on a model of post-traumatic osteoarthrosis in the articular cartilage and on a model of post-traumatic keratitis in the cornea. The administration of glucosamine hydrochloride stimulated repair and favored inhibition of dystrophic post-traumatic processes in the connective-tissue structures. It is suggested that a probable mechanism of the drug action consists in stimulation of the synthesis of glucosaminoglycanes and collagen.
authors.affiliation: Clinical Pharmacy Department, National Pharmaceutical Academy of Ukraine, ul. Pushkinskaya 53, Kharkov 61002, Ukraine.
authors.forename: I A
authors.initials: IA
authors.lastname: Zupanets
authors.forename: N V
authors.initials: NV
authors.lastname: Bezdetko
authors.forename: N V
authors.initials: NV
authors.lastname: Dedukh
authors.forename: I A
authors.initials: IA
authors.lastname: Otrishko
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000293:injuries* / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism; D005944:Glucosamine / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000378:metabolism; D007634:Keratitis / Q000209:etiology / Q000378:metabolism; D015207:Osteoarthritis, Hip / Q000209:etiology / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006025:Glycosaminoglycans; D005944:Glucosamine