title: Predictive factors and timing for liver recurrence after curative resection of gastric carcinoma.
abstract: BACKGROUND
  Advanced and reliable diagnostic methods in order to identify the site of recurrence of gastric cancer in an early stage are needed.
  
  
  METHODS
  One hundred twenty patients whose recurrence was confirmed after curative resection for gastric cancer were enrolled in this study.
  
  
  RESULTS
  Liver recurrence was evident in 41 patients. Advanced age, tumor invasion into subserosa, intestinal and mixed type of histology, Borrmann type 0 to 2, tumor diameter (<6.5 cm), and tumor marker (carcinoembryonic antigen and alpha-fetoprotein) elevation were related to liver recurrence. By logistic regression analysis, independent risk factors for liver recurrence included Borrmann's classification, histology, and tumor marker elevation. The median time from the primary operation to liver recurrence was shortest in the tumor marker elevation group when compared with other independent predictors.
  
  
  CONCLUSIONS
  This information may help to design a better follow-up program and appropriate treatment strategy for gastric cancer patients with liver metastasis.
authors.affiliation: Department of Complementary and Alternative Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Ishikawa 920-8640, Japan. satoshio@med.kanazawa-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujii
authors.forename: Shuhei
authors.initials: S
authors.lastname: Ueda
authors.forename: Takeru
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Shoichi
authors.initials: S
authors.lastname: Kinugasa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tachibana
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kubota
authors.forename: Dipok
authors.initials: D
authors.lastname: Kumar Dhar
authors.forename: Naofumi
authors.initials: N
authors.lastname: Nagasue
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary*; D016015:Logistic Models; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins