title: Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use.
abstract: Heparin-induced thrombocytopenia (HIT), a serious complication of heparin therapy, mandates heparin cessation and alternative anticoagulation. We report a patient with a history of HIT who successfully underwent cardiopulmonary bypass (CPB) using short-term reexposure to heparin and perioperative therapy with argatroban. No bleeding complications or HIT-related problems occurred. The pharmacokinetics of argatroban, especially its hepatic rather than renal elimination, makes it the drug of choice for some HIT patients in whom other alternative anticoagulants (eg, danaparoid and hirudin) are less well suited. Because of interference with the international normalized ratio (INR), switching from argatroban to oral anticoagulants is not straightforward.
authors.affiliation: Institute of Immunology and Transfusion Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany. lubenow@uni-greifswald.de
authors.forename: Norbert
authors.initials: N
authors.lastname: Lubenow
authors.forename: Sixten
authors.initials: S
authors.lastname: Selleng
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Wollert
authors.forename: Petra
authors.initials: P
authors.lastname: Eichler
authors.forename: Bernd
authors.initials: B
authors.lastname: Müllejans
authors.forename: Andreas
authors.initials: A
authors.lastname: Greinacher
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D002315:Cardiopulmonary Bypass; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D010875:Pipecolic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban