A summary of results of the Dietary Intervention Study in Children (DISC): lessons learned.
Prevention of cardiovascular disease must begin in childhood, preferably before risk factors develop. Elevated low-density lipoprotein cholesterol levels in children are likely to track over time and become high-risk levels in adults. The Dietary Intervention Study in Children (DISC) was a multicenter, collaborative randomized trial in pre-adolescent children designed to test the efficacy and safety of a dietary intervention to lower saturated fat and cholesterol intake among growing children with elevated low-density lipoprotein cholesterol. Numerous DISC results, which include findings on lipids-lipoproteins, genetics, and nutrient adequacy, as well as descriptions of the behavioral intervention strategies, have been reported. A summary of practical findings and their potential clinical applications have not previously been published. Highlights of key lessons learned from DISC and translational applications of potential interest to nurses and other health care providers are presented.
Van Horn
Linda
L
Department of Preventive Medicine, Northwestern University Medical School, 680 North Lake Shore Drive, #1102, Chicago, IL 60611, USA. LVanhorn@Northwestern.edu
Obarzanek
Eva
E
Barton
Bruce A
BA
Stevens
Victor J
VJ
Kwiterovich
Peter O
PO
Lasser
Norman L
NL
Robson
Alan M
AM
Franklin
Frank A
FA
Lauer
Ronald M
RM
Kimm
Sue Y S
SY
Dorgan
Joanne F
JF
Greenlick
Merwyn R
MR
D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism*; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007858:Learning; D008297:Male; D009752:Nutritional Status / Q000502:physiology; D011237:Predictive Value of Tests; D011581:Psychological Tests; D012741:Sexual Maturation / Q000502:physiology; D012959:Socioeconomic Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D014810:Vitamin E / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D014810:Vitamin E; D005293:Ferritins; D015032:Zinc