title: A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides.
abstract: A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Frederick
authors.forename: Jason A
authors.initials: JA
authors.lastname: Mulder
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tracey
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Kimberly C M
authors.initials: KC
authors.lastname: Kurtz
authors.forename: Lichun
authors.initials: L
authors.lastname: Shen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Douglas