Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs.
In two recent clinical trials, a vaccine containing herpes simplex virus (HSV) type 2 glycoprotein D (gD2) and a novel adjuvant AS04 comprising alum (Al) and 3-deactylated monophosphoryl lipid A (3-dMPL) afforded HSV-seronegative women significant protection against HSV-2 genital disease (vaccine efficacy, 73% in study 1 and 74% in study 2) and limited protection against infection (46% in study 1 and 39% in study 2). In the present report, studies in the guinea pig model investigated the protection afforded by gD2/AS04 against HSV-1 and HSV-2 genital herpes and investigated whether immunization could prevent or reduce recurrent disease in guinea pigs that developed mucosal infection. Immunization with gD2/AS04 conveyed nearly complete protection against primary disease with either virus but did not prevent mucosal infection. Guinea pigs immunized with gD2/AS04 were significantly better protected against recurrent disease than were guinea pigs immunized with a gD2/Al vaccine, which suggests that inclusion of 3-dMPL improved protection against latent infection.
Bourne
Nigel
N
Division of Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio, USA. nibourne@utmb.edu
Bravo
Fernando J
FJ
Francotte
Myriam
M
Bernstein
David I
DI
Myers
Martin G
MG
Slaoui
Moncef
M
Stanberry
Lawrence R
LR
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000517:prevention & control* / Q000821:virology; D006561:Herpes Simplex / Q000517:prevention & control*; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage*; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human / Q000276:immunology; D055502:Secondary Prevention; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014759:Viral Envelope Proteins / Q000008:administration & dosage* / Q000276:immunology
D022301:Herpes Simplex Virus Vaccines; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; C040570:glycoprotein D-herpes simplex virus type 2