title: Olfactory neuroblastoma: past, present, and future?
abstract: OBJECTIVE
  To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection.
  
  
  METHODS
  A single-center prospective cohort study.
  
  
  METHODS
  All patients with olfactory neuroblastoma treated in a 23-year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included.
  
  
  RESULTS
  Forty-two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow-up ranged from 2 to 206 months (mean follow-up period, 57 mo). The disease-free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome.
  
  
  CONCLUSIONS
  Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.
authors.affiliation: Institute of Laryngology and Otology, University College London, 330 Gray's Inn Road, London WC1X 8DA, UK. v.lund@ucl.ac.uk
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Lund
authors.forename: David
authors.initials: D
authors.lastname: Howard
authors.forename: William
authors.initials: W
authors.lastname: Wei
authors.forename: Margaret
authors.initials: M
authors.lastname: Spittle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009296:Nasal Cavity / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery*; D009669:Nose Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D011446:Prospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods; D017741:Survivors