Association of HLA-DR and type II collagen autoimmunity with Meniere's disease.
To investigate HLA-associated genetic susceptibility to Meniere's disease in relation to type II collagen (CII) autoimmunity status, HLA-DRB1 genotyping and ELISA measurement of anti-CII antibody were performed in 41 Korean patients with Meniere's disease. In the anti-CII positive subgroup (20%) of patients, the frequency of HLA-DRB1*0405 was significantly increased (uncorrected) compared with both controls (63% vs 16%) and anti-CII negative patients (63% vs 12%). In the anti-CII negative subgroup, HLA-DRB1*1201 was significantly increased (uncorrected) (27% vs 10%) and DRB1*13 was decreased (6% vs 24%) compared with controls; these alleles appeared to confer susceptibility and resistance to the development of the disease. Association of HLA-DRB1*0405 with anti-CII positive Meniere's disease in this study suggests that it shares a specific HLA-DR sequence, QRRAA, as a genetic susceptibility factor with the anti-CII positive rheumatoid arthritis. In conclusion, whilst type II collagen autoimmunity may have a partial role in Meniere's disease, different HLA-DR alleles may also be associated with either susceptibility or resistance to the development of the disease in relation to anti-CII antibody status.
Koo
J-W
JW
Department of Otolaryngology, Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea.
Oh
S H
SH
Chang
S O
SO
Park
M H
MH
Lim
M J
MJ
Yoo
T-J
TJ
Kim
C S
CS
D000328:Adult; D000368:Aged; D000483:Alleles; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D024043:Collagen Type II / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000235:genetics* / Q000276:immunology*; D012698:Serologic Tests
D001323:Autoantibodies; D024043:Collagen Type II; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains