title: Effects of monensin on Na+/K(+)-ATPase and Ca(++)-AtPase activities in chick skeletal muscle and myocardium after subacute treatment.
abstract: Chicks were treated at 2 weeks of age with 4,15, 40, 100 and 150 mg/kg of monensin, an ionophore used for its anticoccidial and growth-promoting properties. In the present immunohistochemical study, the expressions and distribution of Na+/K(+)-ATPase and Ca(++)-ATPase were studied in myocardium and skeletal muscles (pectoral and quadriceps femoris). We detected an increase of Na+/K(+)-ATPase immunostaining with prominent staining of the sarcolemma and a slight increase of Ca(+)-ATPase with prominent staining of the sarcoplasma.
authors.affiliation: Dipartimento di Patologia, Malattie Infettive e Parassitarie e Ispezione degli Alimenti di Origine Animale, Facoltà di Medicina Veterinaria, University of Messina, Polo S.S. Annunziata, 98168 Messina, Italy. mcalo@unime.it
authors.forename: M
authors.initials: M
authors.lastname: Calò
authors.forename: P
authors.initials: P
authors.lastname: Lo Cascio
authors.forename: P
authors.initials: P
authors.lastname: Licata
authors.forename: A
authors.initials: A
authors.lastname: Richetti
authors.forename: G
authors.initials: G
authors.lastname: Zaccone
authors.forename: F
authors.initials: F
authors.lastname: Naccari
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002645:Chickens / Q000502:physiology*; D006321:Heart / Q000187:drug effects; D007124:Immunoenzyme Techniques; D007476:Ionophores / Q000494:pharmacology*; D008297:Male; D008985:Monensin / Q000494:pharmacology*; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D007476:Ionophores; D008985:Monensin; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase