Cryoanalgesia: electrophysiology at different temperatures.
Somatosensory evoked potentials (SEP) and sensory conduction velocity (SCV) were measured in rabbit sciatic nerves following graded cold lesioning. The SEP disappeared when injury was induced at temperatures below -60 degrees C, but returned on day 41+/-4 (mean+/-SD). SEP returned on day 56+/-11 days when the lesion was induced at 100 to -180 degrees C. The SEP latency was prolonged after creating lesions at -100 to -180 degrees C, compared with both the sham operated and the -20 degrees C groups. These experiments suggest the cryolesions produced at temperatures between -60 and -100 degrees C are most suitable for altering the electrophysiological conduction of the nerve, and may result in suitable post-operative analgesia.
Zhou
Linqiu
L
Department of Physical Medicine and Rehabilitation, University of Pennsylvania, 3400 Spruce Street, 5 West Gate Building, Philadelphia, PA 19104, USA. linqiu.zhou@uphs.upenn.edu
Shao
Zhenhai
Z
Ou
Shihuan
S
D000698:Analgesia / Q000379:methods*; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects; D004594:Electrophysiology; D005073:Evoked Potentials, Somatosensory; D007036:Hypothermia, Induced; D009416:Nerve Regeneration; D009431:Neural Conduction; D011817:Rabbits; D011930:Reaction Time; D012584:Sciatic Nerve / Q000293:injuries* / Q000502:physiology; D013696:Temperature