title: A case of chronic myeloid leukemia complicated with minimal change nephrotic syndrome.
abstract: We present a 28-year-old patient with chronic myeloid leukemia (CML) in chronic phase complicated with nephrotic syndrome. The bone marrow cells revealed the presence of Philadelphia chromosome, the cytogenetic hallmark of CML, that results from a balanced, reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11). This reciprocal translocation leads to the formation of the BCR/ABL fusion gene, the presence of which was confirmed using the highly sensitive fluorescence in situ hybridization technique. The renal biopsy was compatible with minimal change nephrotic syndrome. To the best of our knowledge, this is the first case of minimal change nephrotic syndrome associated with CML before the administration of any therapy.
authors.affiliation: Department of Anatomy, All-India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Talwar
authors.forename: S C
authors.initials: SC
authors.lastname: Dash
authors.forename: Kiran
authors.initials: K
authors.lastname: Kucheria
mesh_terms: D000328:Adult; D001706:Biopsy; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007668:Kidney / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000175:diagnosis; D011507:Proteinuria; D014178:Translocation, Genetic; D014463:Ultrasonography
chemical_list: D016044:Fusion Proteins, bcr-abl