[Influence of placenta on fetal hypoxia in intrahepatic cholestasis of pregnancy].
OBJECTIVE
To determine the influence of placenta on fetal hypoxia in intrahepatic cholestasis of pregnancy (ICP).


METHODS
The transfer of oxygen across the placental membranes in ICP group (n = 7) was compared with that of controls (n = 8) by dual perfusion of the human placental lobule in vitro.


RESULTS
The oxygen consumption and the volume loss of perfusate from the fetal circuit (< 5 ml/h) of placental lobule from women with ICP are similar to controls. The rate of oxygen transfer across the placental membranes in ICP was similar to controls, too (P < 0.05, Power > 0.08). These findings suggest that the transfer of oxygen across the placental membrane in ICP is normal value.


CONCLUSIONS
The placenta in ICP has not direct impact on the fetal oxygenation just leads to insufficiency of placental oxygen reserve resulting from a reduction in the size of the intervilous space.
Wang
Xiaodong
X
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Liu
Shuyun
S
Heng
Zhengchang
Z
D000328:Adult; D002780:Cholestasis, Intrahepatic; D005260:Female; D005311:Fetal Hypoxia / Q000209:etiology*; D006801:Humans; D010101:Oxygen Consumption; D010920:Placenta / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications