Evaluation of stability of enalapril maleate in solid phase.
The influence of temperature (from 383 to 348 K) and relative humidity (from 25.0 to 76.4%) on the stability of enalapril maleate in the solid phase was investigated. Changes in the concentration enalapril maleate were followed by a HPLC method with UV detection. The kinetic and thermodynamic parameters [E(a) (kJ mol(-1))=168.5+/-27 for RH=0% and 149.1+/-48 for RH=76.4%; deltaH(not equal ) (kJ mol(-1))=166.1+/-30 for RH=0% and 146.6+/-50 for RH=76.4%; deltaS(not equal) (J (K(-1) mol(-1)))=120.3+/-169 for RH=0% and 82.1+/-110 for RH=76.4%) of the decomposition reaction were calculated.
Stanisz
Beata
B
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka, 60-780 Poznan, Poland. bstanisz@eucalyptus.usoms.poznan.pl
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004656:Enalapril / Q000737:chemistry*; D007700:Kinetics; D012680:Sensitivity and Specificity; D013816:Thermodynamics
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril