Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae.
Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective.
Ngamying
Maeya
M
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.
Sawanpanyalert
Pathom
P
Butraporn
Raywadee
R
Nikasri
Junjira
J
Cho
Sang-Nae
SN
Levy
Louis
L
Brennan
Patrick J
PJ
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D017358:Cell Wall Skeleton / Q000276:immunology; D005260:Female; D007918:Leprosy / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology*; D014611:Vaccination
D001428:Bacterial Vaccines; D017358:Cell Wall Skeleton