Cherubism in siblings: a case report.
Cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance. Cherubism may appear in solitary cases or in many members of the same family, often in multiple generations. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathologic evaluation reveals proliferating fibrous connective tissue containing numerous multinucleated giant cells. Since the first description of this condition in 1933, almost 200 cases have been reported. We describe cherubism in 2 siblings and briefly review the literature on this subject.
Ongole
Ravikiran
R
Department of Oral Medicine, Diagnosis and Radiology, College of Dental Surgery, Manipal 576119, India. ravikirano@hotmail.com
Pillai
Rejeev S
RS
Pai
Keerthilatha M
KM
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002636:Cherubism / Q000097:blood / Q000235:genetics* / Q000473:pathology; D002648:Child; D002894:Chromosomes, Human, Pair 4; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood; D008297:Male; D008336:Mandibular Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D010758:Phosphorus / Q000097:blood; D035781:Siblings
D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium