title: A new bioactive steroidal saponin from Sansevieria cylindrica.
abstract: A new steroidal saponin was isolated from the leaves of Sansevieria cylindrica. Its structure was established as (3beta,12beta,15alpha,25S)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl 12-O- (6-deoxy-alpha-L-mannopyranosyl)-15-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside. The structural identification was performed using detailed analyses of (1)H and (13)C NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR, HMBC and HMQC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturiais, Laboratório de Química de Plantas Medicinais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, CEP 21944-970 Rio de Janeiro, RJ, Brasil.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Da Silva Antunes
authors.forename: Bernadete Pereira
authors.initials: BP
authors.lastname: Da Silva
authors.forename: José Paz
authors.initials: JP
authors.lastname: Parente
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Valente
mesh_terms: D019342:Acetic Acid; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D031444:Sansevieria; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013256:Steroids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D019342:Acetic Acid