title: Adrenomedullin concentrations are elevated in plasma of patients with primary hyperparathyroidism.
abstract: The aim of the study was to evaluate plasma adrenomedullin (AM) concentration in primary hyperparathyroidism (PHP) and its effect on the regulation of blood pressure. Forty-one patients with PHP (25 normotensive and 16 hypertensive), and 31 healthy subjects (HS) were included in the study. As expected the total and ionized calcium and i-PTH serum levels were significantly higher in patients with PHP than in HS (P <.001). No significant difference was found in calcium-phosphorus metabolism parameters between normotensive and hypertensive PHP patients. Serum i-PTH levels correlated positively with systolic blood pressure (SBP) (r = 0.510; P <.02), diastolic blood pressure (DBP) (r = 0.586; P <.01) and heart rate (HR) (r = 0.486; P <.043) only in hypertensive PHP patients. Overall, mean plasma AM concentrations were significantly higher in PHP patients (16.1 +/- 7.9 pg/mL) than in HS (11.3 +/- 4.8 pg/mL) (P <.003) and correlated with i-PTH (r = 0.430; P <.005). However, in hypertensive PHP patients plasma AM levels (22.5 +/- 4.7 pg/mL) were higher than in normotensive PHP patients (11.6 +/- 1.8 pg/mL) (P <.001) and correlated with DBP (r = 0.902, P <.0029). In HS no correlation was found between plasma AM values and biohumoral, hormonal, or hemodynamic parameters. In conclusion, we demonstrated that in patients with PHP, plasma AM concentrations are increased and correlate with i-PTH and blood pressure values. We suggest that increased AM levels could be a compensatory factor in the defence mechanism against further blood pressure elevation.
authors.affiliation: Department of Clinical Sciences, Chair of Internal Medicine, University of Rome La Sapienza, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Letizia
authors.forename: C
authors.initials: C
authors.lastname: Caliumi
authors.forename: E
authors.initials: E
authors.lastname: Delfini
authors.forename: M
authors.initials: M
authors.lastname: Celi
authors.forename: S
authors.initials: S
authors.lastname: Subioli
authors.forename: D
authors.initials: D
authors.lastname: Diacinti
authors.forename: S
authors.initials: S
authors.lastname: Minisola
authors.forename: E
authors.initials: E
authors.lastname: D'erasmo
authors.forename: G F
authors.initials: GF
authors.lastname: Mazzuoli
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D005260:Female; D006339:Heart Rate; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood*; D012016:Reference Values
chemical_list: D010281:Parathyroid Hormone; D010455:Peptides; D053607:Adrenomedullin; D002118:Calcium