Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones.
A new series of 3-benzyl(p-substituted benzyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones (8a-e) were synthesized. These products were prepared by Knoevenagel reaction from 3'-flavone carboxaldehyde and 3-substituted 2,4-thiazolidinediones. In vitro insulinotropic activity was determined for compounds 6a-e, 7a-e, 8b and 8c.
Tunçbilek
Meral
M
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Turkey.
Bozdağ-Dündar
Oya
O
Ayhan-Kilcigil
Gülgün
G
Ceylan
Meltem
M
Waheed
Abdül
A
Verspohl
Eugen J
EJ
Ertan
Rahmiye
R
D000818:Animals; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D047309:Flavones; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D045162:Thiazolidinediones; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001593:Benzyl Compounds; D047309:Flavones; D005419:Flavonoids; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione; C043562:flavone