Genetic control of surface curvature.
Although curvature of biological surfaces has been considered from mathematical and biophysical perspectives, its molecular and developmental basis is unclear. We have studied the cin mutant of Antirrhinum, which has crinkly rather than flat leaves. Leaves of cin display excess growth in marginal regions, resulting in a gradual introduction of negative curvature during development. This reflects a change in the shape and the progression of a cell-cycle arrest front moving from the leaf tip toward the base. CIN encodes a TCP protein and is expressed downstream of the arrest front. We propose that CIN promotes zero curvature (flatness) by making cells more sensitive to an arrest signal, particularly in marginal regions.
Nath
Utpal
U
Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
Crawford
Brian C W
BC
Carpenter
Rosemary
R
Coen
Enrico
E
D000595:Amino Acid Sequence; D032161:Antirrhinum / Q000166:cytology / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D001483:Base Sequence; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D048429:Cell Size; D056743:Cyclin D3; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D017353:Gene Deletion; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D006657:Histones / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009154:Mutation; D018515:Plant Leaves / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013499:Surface Properties; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D056743:Cyclin D3; D016213:Cyclins; D006657:Histones; D010940:Plant Proteins; D014157:Transcription Factors