Singlet oxygen (1O2)-oxidazable lipids in the HIV membrane, new targets for AIDS therapy?
Human immunodeficiency virus (HIV) is a lipid enveloped virus. The lipid envelope differs significantly from the lipid membrane of normal human cells: it contains high amounts of cholesterol, that is of importance for the virus-cell interaction (for entry and exit of the virus) at so-called lipid rafts. Cholesterol, as a R-C=C-R compound possesses an oxidazable carbenic bond. The present work suggests the inactivation of HIV by oxidation of viral cholesterol and/or unsaturated fatty acids. For oxidation, the relatively mild oxidant singlet oxygen (1O(2)) might be used. 1O(2) is generated by redoxcyclers (e.g., of the quinone type, such as vitamin K) or by chloramines (e.g., taurine-chloramine). At the 1O(2) concentrations necessary to inactivate lipid enveloped virus in human blood the oxidation-sensible critical hemostasis parameters such as thrombocytes and fibrinogen are only partly inactivated. Therefore, it is proposed to consider generators of 1O(2) as a new form of AIDS therapy.
Stief
Thomas W
TW
Institute of Clinical Chemistry, University Hospital, Marburg, Germany. thstief@post.med.uni-marburg.de
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D005227:Fatty Acids / Q000378:metabolism; D006678:HIV / Q000378:metabolism*; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism; D008962:Models, Theoretical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D026082:Singlet Oxygen / Q000378:metabolism*; D013997:Time Factors
D005227:Fatty Acids; D008051:Lipid Bilayers; D026082:Singlet Oxygen; D010100:Oxygen