title: Definitive identification of cysteine and glutathione complexes of bismuth by mass spectrometry: assessing the biochemical fate of bismuth pharmaceutical agents.
abstract: Solutions containing BiCl3, bismuth subsalicylate or Bi(NO3)3 with L-cysteine, DL-homocysteine, D-methionine or glutathione have been examined by electrospray mass spectrometry. Prominent peaks are assigned to bismuth complexes of these biomolecules and provide insight towards understanding the bioactivity of bismuth compounds.
authors.affiliation: Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada. neil.burford@dal.ca
authors.forename: Neil
authors.initials: N
authors.lastname: Burford
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Eelman
authors.forename: David E
authors.initials: DE
authors.lastname: Mahony
authors.forename: Michael
authors.initials: M
authors.lastname: Morash
mesh_terms: D001729:Bismuth / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004364:Pharmaceutical Preparations; D005978:Glutathione; D003545:Cysteine; D001729:Bismuth