[Effect of propofol and ketamine on lipid metabolism and lipid peroxidation in rats].
Ketamine (50 mg/kg, i.p.) increases the intensity of lipolysis in Wistar male rats, as manifested by increasing content of nonetherified fatty acids and cholesterol in the blood serum. This drug also enhances the lipid peroxidation (LPO) process, as manifested by the content of LPO products in the blood serum and in the liver and heart tissues. Propofol in the same dose also influences the lipid metabolism and LPO intensity, but to a lower extent.
Abidova
S S
SS
Laboratory of Biochemistry, Center of Chemical Sciences, ul. Farkhadskaya 10, Tashkent, 700115 Uzbekistan.
D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D007274:Injections, Intraperitoneal; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000777:Anesthetics; D008055:Lipids; D007649:Ketamine; D015742:Propofol