title: Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats.
abstract: The present study was carried out to evaluate the antihyperglycaemic effect of Casearia esculenta root extract and to study the activities of liver hexokinase and gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase in liver and kidney of normal and streptozotocin-induced diabetic rats. Oral administration of aqueous extract of root (300 mg/kg body weight) for 45 days resulted in a significant reduction in blood glucose from 250.79 +/- 12.65 to 135.70 +/- 8.90 and in a decrease in the activities of glucose-6-phosphatase and fructose-1,6-bishosphatase and an increase in the activity of liver hexokinase. However, in the case of 200 mg/kg body weight of extract, less activity was observed. The study clearly shows that the root extract of C. esculenta possesses potent antihyperglycaemic activity but weaker than that of glibenclamide.
authors.affiliation: Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu, India.
authors.forename: A
authors.initials: A
authors.lastname: Prakasam
authors.forename: S
authors.initials: S
authors.lastname: Sethupathy
authors.forename: K V
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D037821:Casearia / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D006597:Fructose-Bisphosphatase / Q000097:blood / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000097:blood / Q000378:metabolism; D005905:Glyburide / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism; D006593:Hexokinase / Q000097:blood / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D005905:Glyburide; D006442:Glycated Hemoglobin; D006593:Hexokinase; D007004:Hypoglycemic Agents; D010936:Plant Extracts