title: Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.
abstract: Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.
authors.affiliation: Department of Zoology, M.L.S. University, Udaipur 313 001, India. mbhatnagar@yahoo.com
authors.forename: Maheep
authors.initials: M
authors.lastname: Bhatnagar
authors.forename: Pratima
authors.initials: P
authors.lastname: Rao
authors.forename: Jain
authors.initials: J
authors.lastname: Sushma
authors.forename: Rekha
authors.initials: R
authors.lastname: Bhatnagar
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D005459:Fluorides / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D051379:Mice
chemical_list: D005459:Fluorides