title: Involvement of calcitonin gene-related peptide in the depressor effects of losartan and perindopril in rats.
abstract: Previous investigations have indicated that calcitonin gene-related peptide (CGRP) plays an important role in the regulation of cardiovascular function, and that the development of hypertension may be related to the reduction of sensory vasodilator nerve actions. In the present study, we examined the effect of perindopril, an angiotensin-converting enzyme inhibitor, and losartan, an angiotensin II receptor antagonist, on the plasma level and synthesis of CGRP in 2 kidneys, 1-clip hypertensive rats (2K1C, Goldblatt). In the hypertension group, systolic blood pressure and mean artery pressure were raised, and the level of CGRP in plasma was slightly raised compared with control groups. Chronic treatment with losartan or perindopril significantly increased the plasma concentration of CGRP and the expression of CGRP mRNA in dorsal root ganglia in the 2K1C, Goldblatt hypertensive rats. These results suggest that the 2K1C, Goldblatt hypertensive model has a compensatory increase of sensory nerve actions, and that the depressor effects of perindopril or losartan may be related to stimulation of the synthesis and release of CGRP in the 2K1C, Goldblatt hypertensive rats.
authors.affiliation: Department of Pharmacology, Xiang-Ya School of Medicine, Central South University, Hunan 410078., Changsha, PR China.
authors.forename: Xu-Ping
authors.initials: XP
authors.lastname: Qin
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Duan-Fang
authors.initials: DF
authors.lastname: Liao
authors.forename: Yuan-Jian
authors.initials: YJ
authors.lastname: Li
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood* / Q000235:genetics; D015870:Gene Expression; D006978:Hypertension, Renovascular / Q000235:genetics / Q000503:physiopathology; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D020913:Perindopril / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D012333:RNA, Messenger; D015740:Calcitonin Gene-Related Peptide; D019808:Losartan; D020913:Perindopril