title: Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones.
abstract: A new series of 3-benzyl(p-substituted benzyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones (8a-e) were synthesized. These products were prepared by Knoevenagel reaction from 3'-flavone carboxaldehyde and 3-substituted 2,4-thiazolidinediones. In vitro insulinotropic activity was determined for compounds 6a-e, 7a-e, 8b and 8c.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Tunçbilek
authors.forename: Oya
authors.initials: O
authors.lastname: Bozdağ-Dündar
authors.forename: Gülgün
authors.initials: G
authors.lastname: Ayhan-Kilcigil
authors.forename: Meltem
authors.initials: M
authors.lastname: Ceylan
authors.forename: Abdül
authors.initials: A
authors.lastname: Waheed
authors.forename: Eugen J
authors.initials: EJ
authors.lastname: Verspohl
authors.forename: Rahmiye
authors.initials: R
authors.lastname: Ertan
mesh_terms: D000818:Animals; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D047309:Flavones; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D045162:Thiazolidinediones; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D001593:Benzyl Compounds; D047309:Flavones; D005419:Flavonoids; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione; C043562:flavone