title: Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission.
abstract: The present study was designed to assess whether the subtype of human immunodeficiency virus type 1 (HIV-1) could affect the rate of HIV-1 mother-to-child transmission in a cohort of 31 HIV-1-seropositive pregnant Tanzanian women. In order to assign a subtype to the samples analysed, nucleotide sequencing of the HIV-1 long terminal repeat U3 and C2V3C3 envelope regions was performed from the sera of these 31 pregnant women. Except in three cases, amplification of both regions was achieved in all samples. Subtypes A (n=13, 46 %), C (n=6, 21 %) and D (n=2, 7 %), as well as a number (25 %) of A/C, C/A, D/A and C/D recombinant forms (n=3, 2, 1 and 1, respectively), were identified. Of the 31 HIV-1 seropositive pregnant women analysed, eight (26 %) transmitted HIV-1 to their infants. Among the eight transmitter mothers, four (4 of 13, 31 %) were infected with HIV-1 subtype A, one (1 of 6, 17 %) with HIV-1 subtype C, none (0 of 2, 0 %) with HIV-1 subtype D and three (3 of 7, 43 %) with HIV-1 subtype recombinant A/C. These findings show no significant differences in the mother-to-child transmissibility of HIV-1 subtypes A, C and D and detected recombinants forms.
authors.affiliation: Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Natàlia
authors.initials: N
authors.lastname: Tàpia
authors.affiliation: Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Franco
authors.affiliation: Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Puig-Basagoiti
authors.affiliation: Unitat d'Epidemiologia i Bioestadística, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Menéndez
authors.affiliation: Unitat d'Epidemiologia i Bioestadística, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Alonso
authors.affiliation: Ifakara Health Research and Development Centre, Ifakara, Tanzania.
authors.forename: Hassan
authors.initials: H
authors.lastname: Mshinda
authors.affiliation: Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.affiliation: Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pí i Sunyer (IDIBAPS), Hospital Clinic, Facultad de Medicina, Universidad de Barcelona, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Saiz
authors.affiliation: Fundació irsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Martínez
mesh_terms: D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D016325:HIV Long Terminal Repeat; D006679:HIV Seropositivity / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000821:virology*; D012424:Rural Population; D013636:Tanzania; D014759:Viral Envelope Proteins / Q000235:genetics; D019562:Viral Load
chemical_list: D014759:Viral Envelope Proteins