Endothelin-1: a multifunctional molecule in cancer.
Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.
Grant
K
K
Department of Surgery, Royal Free and University College London Medical School, UK.
Loizidou
M
M
Taylor
I
I
D017209:Apoptosis; D018450:Disease Progression; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism; D017466:Receptors, Endothelin / Q000502:physiology
D019332:Endothelin-1; D017466:Receptors, Endothelin