title: No evidence of fetal DNA persistence in maternal plasma after pregnancy.
abstract: Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular microchimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.
authors.affiliation: Department of Obstetrics and Gynecology, H. San Raffaele, Milano, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Smid
authors.forename: Silvia
authors.initials: S
authors.lastname: Galbiati
authors.forename: Antonia
authors.initials: A
authors.lastname: Vassallo
authors.forename: Dania
authors.initials: D
authors.lastname: Gambini
authors.forename: Augusto
authors.initials: A
authors.lastname: Ferrari
authors.forename: Elsa
authors.initials: E
authors.lastname: Viora
authors.forename: Marco
authors.initials: M
authors.lastname: Pagliano
authors.forename: Gabriella
authors.initials: G
authors.lastname: Restagno
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ferrari
authors.forename: Laura
authors.initials: L
authors.lastname: Cremonesi
mesh_terms: D004247:DNA / Q000097:blood*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D024282:Genes, sry; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy
chemical_list: D004247:DNA