[Adhesive molecules as immunologic markers of activity of multiple sclerosis].
The correlations between concentrations of the adhesive circulating molecules cICAM-1 and cVCAM-1 in the peripheral blood of patients with relapses-remitting multiple sclerosis (RRMS) in different clinical phases and magnetic resonance imaging (MRI) activity are presented. The patients in clinically active phase with Gd-enhancing lesions had elevated blood levels of cICAM-1. However, 5 patients without Gd-enhancing lesions exhibited elevated cICAM-1 and cVCAM-1 levels in active phase comparing to those in remission stage that indicate a high level of sensibility of these immunologic parameters.
Miller
A
A
Eninia
G
G
Metra
M
M
Platkaĭs
A
A
Kukaĭne
R
R
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D003287:Contrast Media; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism*
D003287:Contrast Media; D018799:Intercellular Adhesion Molecule-1; D019786:Gadolinium DTPA