title: Colloid osmotic pressure (COP) can be a good indicator of occurrence of vasospasm following subarachnoid hemorrhage (SAH).
abstract: BACKGROUND
  The aim of this study was to evaluate the value of measurement of colloid osmotic pressure (COP) directly concerned with cerebral vasospasm following subarachnoid hemorrhage (SAH).
  
  
  METHODS
  The subjects were 20 patients who received clipping operation within 48 hours after onset. We conducted a two weeks monitoring of COP measured directly by osmometer and evaluated serum concentrations of albumin at the same time. We divided the patients into Group A (angiographical vasospasm +) and Group B (spasm -) according to the angiographical findings. The differences of the data between the groups were analyzed by ANOVA test (p<0.05). Furthermore, the correlations between the serum concentrations of albumin and COP levels were estimated.
  
  
  RESULTS
  Vasospasm was angiographically confirmed in 10 of the 20 patients. Significant decrease of COP levels was observed from day 7 until day 11 and significant decrease of albumin was observed on day 6 and from day 8 until day 11 in the Group A. We did not observe any significant change of COP and albumin levels in the Group B. A liner analysis was performed and a significant correlation was determined between the COP levels and albumin in the Group A, but we did not observe significant correlation between them in the Group B.
  
  
  CONCLUSIONS
  These results showed that a significant decrease of COP levels indicate the occurrence of cerebral vasospasm. We concluded that COP measurement could be a useful monitor of the occurrence of vasospasm following SAH.
authors.affiliation: Division of Critical Care and Emergency Medicine, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hiramitsu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Taniuchi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nagura
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ooshima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012709:Serum Albumin / Q000378:metabolism; D013223:Statistics as Topic; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery; D020301:Vasospasm, Intracranial / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
chemical_list: D012709:Serum Albumin