[1,1, 1-trichloroethane-induced chronic active hepatitis].
1,1, 1-trichloroéthane is derived from carbon tetrachloride and has been widely used as an industrial solvent since 1954, because of its supposed lack of toxicity. However, several cases of central nervous system toxicity and heart disorders due to intoxication by 1,1, 1-trichloroéthane have been reported. Cases of liver injury are infrequent, with less than 10 cases, unlike 1,1, 2-trichloroéthane that it replaced. We report a case of hepatotoxicity probably due to 1,1, 1-trichloroéthane exposure, characterized by an original pathologic feature of chronic active hepatitis.
Croquet
Vincent
V
Service d'Hépato-Gastroentérologie, CHU, 49033 Angers Cedex 01.
Fort
Joël
J
Oberti
Frédéric
F
Roquelaure
Yves
Y
Ben Bouali
Abdel Kader
AK
Pilette
Christophe
C
Calès
Paul
P
D000328:Adult; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D012997:Solvents / Q000506:poisoning*; D013997:Time Factors; D014240:Trichloroethanes / Q000506:poisoning*
D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane