title: Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia.
abstract: Common variable immunodeficiency (CVID) is characterized by a severe hypogammaglobulinemia. While the clinical picture is dominated by recurrent respiratory and gastrointestinal infections, a subgroup of up to 30% of the patients develops additional autoimmune phenomena, including thrombocytopenia and autoimmune hemolytic anemia. So far no classification allowed a prediction of the coincidence of immunodeficiency and autoimmunity. Here, we propose the size of the peripheral CD19(hi)CD2(lo/neg) B cell pool as a marker for CVID patients with autoimmune cytopenia and splenomegaly. Interestingly similar B cell populations are also found in patients with SLE and may not only be an epiphenomenon of the disease.
authors.affiliation: Division of Rheumatology and Clinical Immunology, Dept. of Medicine, University Hospital Freiburg, Germany. warnatz@mm61.ukl.uni-freiburg.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Warnatz
authors.forename: Claudia
authors.initials: C
authors.lastname: Wehr
authors.forename: Ruth
authors.initials: R
authors.lastname: Dräger
authors.forename: Sigune
authors.initials: S
authors.lastname: Schmidt
authors.forename: Hermann
authors.initials: H
authors.lastname: Eibel
authors.forename: Michael
authors.initials: M
authors.lastname: Schlesier
authors.forename: Hans-Hartmut
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000328:Adult; D018941:Antigens, CD19 / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002452:Cell Count; D002648:Child; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000145:classification* / Q000150:complications / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007970:Leukopenia / Q000209:etiology / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D017464:Receptors, Complement 3d / Q000276:immunology; D013163:Splenomegaly / Q000209:etiology / Q000276:immunology
chemical_list: D018941:Antigens, CD19; D017464:Receptors, Complement 3d