Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell proliferation assay.
Kakeya
Hideaki
H
Antibiotics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Takahashi-Ando
Naoko
N
Kimura
Makoto
M
Onose
Rie
R
Yamaguchi
Isamu
I
Osada
Hiroyuki
H
D001203:Ascomycota / Q000145:classification* / Q000378:metabolism*; D001711:Biotransformation; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007659:Ketones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012118:Resorcinols / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015025:Zearalenone / Q000378:metabolism*
C476266:1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'-undecene-6'-one; D004967:Estrogens; D007659:Ketones; D012118:Resorcinols; D015025:Zearalenone