title: Protective immunity against pasteurellosis in cattle, induced by Pasteurella haemolytica ghosts.
abstract: Pasteurella haemolytica is a cattle pathogen of significant economic impact. An effective vaccine against bovine pneumonic pasteurellosis is therefore of high importance. Apart from economic concerns, pasteurellosis caused by P. haemolytica is a serious disease leading to death in cattle if it remains untreated. In this study P. haemolytica-ghosts are presented as a promising vaccine candidate in cattle. To obtain sufficient vaccination material a fermentation protocol for P. haemolytica-ghost production was established. With the obtained experimental P. haemolytica-ghost vaccine, cattle immunization studies were performed based on a Pasteurella cattle challenge model developed specifically for vaccine validation. It was shown that protective immunization of cattle against homologous challenge was induced by adjuvanted P. haemolytica-ghosts. The level of protection was similar to a commercially available vaccine.
authors.affiliation: Institute of Microbiology and Genetics, University of Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Marchart
authors.forename: M
authors.initials: M
authors.lastname: Rehagen
authors.forename: G
authors.initials: G
authors.lastname: Dropmann
authors.forename: M P
authors.initials: MP
authors.lastname: Szostak
authors.forename: S
authors.initials: S
authors.lastname: Alldinger
authors.forename: S
authors.initials: S
authors.lastname: Lechleitner
authors.forename: T
authors.initials: T
authors.lastname: Schlapp
authors.forename: S
authors.initials: S
authors.lastname: Resch
authors.forename: W
authors.initials: W
authors.lastname: Lubitz
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005285:Fermentation; D007114:Immunization; D016978:Mannheimia haemolytica / Q000276:immunology*; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary*; D010957:Plasmids
chemical_list: D001428:Bacterial Vaccines