title: [Effects of xuefuzhuyu decoction on collagen synthesis and proliferation of cardiac fibroblasts].
abstract: OBJECTIVE
  To study the effects of XueFuZhuYu Decoction (XFZYD) on collagen synthesis and proliferation of cardiac fibroblasts and provide academic bases of remedying kinds of heart disease aroused by proliferation of cardiac fibroblasts.
  
  
  METHODS
  By adding medicine directly and serum pharmacological method.
  
  
  RESULTS
  Compared with the control group, 1 g/ml XFZYD(dilution 1:80) and 10 percent serum of rat contained XFZYD could significantly inhibit the collagen synthesis and the proliferation of cardiac fibroblasts. Moreover, 1 g/ml XFZYD(dilution 1:80) could significantly affect collagen secrtion of cardiac fibroblasts (P < 0.05), up to 17.9%.
  
  
  CONCLUSIONS
  XFZYD could inhibit both proliferation and collagen secretion of cardiac fibroblasts. It could resist cardiac muscle fibrosis.
authors.affiliation: Molecular Medical Institute, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053.
authors.forename: Zhishan
authors.initials: Z
authors.lastname: Ding
authors.forename: Chengxian
authors.initials: C
authors.lastname: Gao
authors.forename: Ruirui
authors.initials: R
authors.lastname: Ji
authors.forename: Xingde
authors.initials: X
authors.lastname: Wo
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry*; D027861:Prunus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032267:Rehmannia / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D003094:Collagen