Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women.
A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
Lee
K-M
KM
Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno-Gu, Seoul, Korea.
Abel
J
J
Ko
Y
Y
Harth
V
V
Park
W-Y
WY
Seo
J-S
JS
Yoo
K-Y
KY
Choi
J-Y
JY
Shin
A
A
Ahn
S-H
SH
Noh
D-Y
DY
Hirvonen
A
A
Kang
D
D
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D001141:Aromatase / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D001483:Base Sequence; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D017931:DNA Primers; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
D017931:DNA Primers; D001141:Aromatase; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1