Search for new non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-1 RT).
The derivatives of dibenzoxazocinone, dibenzoxadiazocine, dibenzoxadiazonine, and benzodiazepine systems were synthesized as potential lead compounds for inhibitors of HIV-1 reverse transcriptase. The suggested structures were derived from analysis of the described spatial and physicochemical requirements for HIV-1 RT inhibitors. All of the evaluated compounds (apart from the oxadiazocine derivatives) showed a week inhibitory activity on recombinant HIV-1 RT from Escherichia coli.
Brzezińska
Elzbieta
E
Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńiskiego Str., 90-151 Lódź, Poland.
Glinka
Ryszard
R
D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase