Steroid control of longevity in Drosophila melanogaster.
Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.
Simon
Anne F
AF
Division of Biology 156-29, California Institute of Technology, 1201 California Boulevard, Pasadena, CA 91125, USA.
Shih
Cindy
C
Mack
Antha
A
Benzer
Seymour
S
D000818:Animals; D001835:Body Weight; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D004440:Ecdysone / Q000096:biosynthesis / Q000502:physiology*; D004441:Ecdysterone / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005298:Fertility; D017344:Genes, Insect; D008024:Ligands; D008136:Longevity; D008297:Male; D009154:Mutation; D018384:Oxidative Stress; D018524:Phototropism; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D013217:Starvation; D013696:Temperature
D008024:Ligands; D011987:Receptors, Steroid; C055469:ecdysone receptor; D004440:Ecdysone; D004441:Ecdysterone