Genetics of alcoholism using intermediate phenotypes.
This article represents the proceedings of a symposium at the 2002 meeting of the Research Society on Alcoholism in San Francisco, CA. It was organized by Mary-Anne Enoch and David Goldman and chaired by David Goldman. The presentations were (1) Two functional polymorphisms and their intermediate phenotypes in complex behaviors: COMT/executive cognition and anxiety and HTT/anxiety, by David Goldman; (2) Role of the EEG in determining genetic risk for alcoholism and anxiety disorders, by Mary-Anne Enoch; (3) The response to alcohol as an intermediate phenotype for alcoholism, by Marc A. Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson.
Enoch
Mary-Anne
MA
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892-8110, USA. maenoch@niaaa.nih.gov
Schuckit
Marc A
MA
Johnson
Bankole A
BA
Goldman
David
D
D000428:Alcohol Drinking / Q000235:genetics; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D001008:Anxiety Disorders / Q000235:genetics / Q000503:physiopathology; D002352:Carrier Proteins / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics; D002874:Chromosome Mapping; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C493231:Slc6a4 protein, mouse; D002394:Catechol O-Methyltransferase