title: Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea pig.
abstract: OBJECTIVE
  To determine the effect of interleukin-1 receptor antagonist (IL-1ra) on allergic rhinitis.
  
  
  METHODS
  Allergic rhinitis was induced by toluene-2,4-diisocyanate (TDI). At the end of the treatment, the pathological changes in the nasal mucosa were observed. The concentrations of histamine in the nasal mucosa and IgE in the blood were determined as well.
  
  
  RESULTS
  Symptoms of allergic rhinitis were remarkably relieved after IL-1ra treatment. Hematoxylin and eosin staining demonstrated that less edema was found in the nasal mucosa and small vessel was normal after IL-1ra application, but edema,vasodilation, and inflammatory cell infiltration were discovered in the model group. The concentrations of histamine in the nasal mucosa and IgE in the blood were less than those in the control group.
  
  
  CONCLUSIONS
  IL-1ra im administration selectively and non-traumatically alleviated nasal congestion, rhinorrhea, and sneezing.
authors.affiliation: The Medical and Pharmaceutical Academy of Yangzhou Univerity, 225001, China.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012795:Sialoglycoproteins / Q000627:therapeutic use*; D014051:Toluene 2,4-Diisocyanate
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E; D006632:Histamine