Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men.
Endothelin-1 plays an important role as a paracrine factor in the regulation of regional blood flow. Plasma levels may represent the net result of spill-over from local stimulation/release and elimination of endothelin-1. In order to compare changes in the concentration of endothelin-1 in the plasma of subjects performing different types of sports exercises we measured immunoreactive endothelin-1 in healthy volunteers ( n=20) performing in random order jogging on a treadmill and cycling on a bicycle ergometer, for 30 min each. Plasma immunoreactive endothelin-1 increased significantly after jogging (2.13+/-0.8 pg/ml versus 2.6+/-0.8 pg/ml, before and after exercise, respectively, P<0.03), whereas it decreased after cycling (2.45+/-0.76 pg/ml versus 2.25+/-0.9 pg/ml, before and after exercise, respectively, P<0.03). We suggest that microtraumatizing effects on the endothelial lining are more pronounced during jogging than during cycling, resulting in a greater increase in plasma endothelin-1, which is too high to be immediately eliminated by the lung despite exercise-induced enhanced pulmonary perfusion. In contrast, similarly enhanced lung perfusion together with a relatively lower stimulation of endothelin-1 compared with jogging, may explain the net decrease in plasma after cycling.
Lewczuk
P
P
Departments of Neurology and Psychiatry, Georg-August-University, and Max-Planck-Institute for Experimental Medicine, Goettingen, Germany.
Söhnchen
N
N
Kele
H
H
Reimers
C D
CD
Ehrenreich
H
H
D000328:Adult; D001642:Bicycling; D019332:Endothelin-1 / Q000097:blood*; D006801:Humans; D007590:Jogging; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology
D019332:Endothelin-1