title: YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.
abstract: A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.
authors.affiliation: Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. nagai@yamanouchi.co.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kamigiri
authors.forename: Hisao
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamaoka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimoi
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001203:Ascomycota / Q000145:classification* / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D002965:Classification; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D017261:Glycosylphosphatidylinositols / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D014871:Water Microbiology
chemical_list: D000475:Alkenes; D000935:Antifungal Agents; D017261:Glycosylphosphatidylinositols; D007783:Lactones; C472172:YM-202204