Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.
The aim of the study was to explore a possible association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cervical neoplasia. A total of 229 women were subjected to cytologic and colposcopic evaluation. Ninety-one of them were found to be normal, and served as the control group, while the other 138 of them had present or past histologically proven cervical pathology (patients group). All patients and controls were investigated for the MTHFR C677T polymorphism. Statistical analysis between the groups of cases with cervical intraepithelial neoplasia or invasive cervical cancer and the control group did not reveal any statistically significant difference in the frequency of the MTHFR C677T polymorphism.
Lambropoulos
A F
AF
Department of Biology and Genetics, Medical Faculty, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. lambrop@med.auth.gr
Agorastos
T
T
Foka
Z J
ZJ
Chrisafi
S
S
Constantinidis
T C
TC
Bontis
J
J
Kotsis
A
A
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D019175:DNA Methylation; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D018895:Microsatellite Repeats; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D014626:Vaginal Smears
D017931:DNA Primers; D005492:Folic Acid; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)