title: Mammalian fatty acid synthase: closure on a textbook mechanism?
abstract: Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh evidence has upset this view.
authors.affiliation: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Leadlay
authors.forename: Abel
authors.initials: A
authors.lastname: Baerga-Ortiz
mesh_terms: D000818:Animals; D064429:Fatty Acid Synthases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005816:Genetic Complementation Test; D006801:Humans; D007313:Insecta; D008958:Models, Molecular; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D011994:Recombinant Proteins; D064429:Fatty Acid Synthases