[Hepatorenal syndrome in view of experimental studies].
Hepatorenal syndrome is still one of the most important challenges of medicine in the 21st century. In spite of many years of experimental and clinical studies, it failed to discover precise pathomechanisms leading from hepatic damage to functional renal failure. Among many directions and types of present scientific researches, experimental studies play a great role. In the paper most often used and most commonly accepted experimental models of hepatorenal syndrome are presented. The technique is described of conducting the experiments and the signs and biochemical and histopathological disorders occurring in experimental animals are discussed. Individual models are compared with respect to their value and usefulness in experimental studies of hepatorenal syndrome and at the same time attempt has been made to answer the question whether we have any ideal experimental model of this important, yet not fully elucidated clinical syndrome.
Saracyn
Marek
M
Klinika Nefrologii ze Stacja Dializ Centralnego Szpitala Klinicznego WAM w Warszawie. msaracyn@cskwam.mil.pl
D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects; D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000098:blood supply; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000209:etiology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced; D017114:Liver Failure, Acute / Q000139:chemically induced; D023421:Models, Animal; D012107:Research Design
D002251:Carbon Tetrachloride