Clodronate liposomes: perspectives in research and therapeutics.
Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
van Rooijen
Nico
N
Department of Molecular Cell Biology, Research Institute of Immunology & Inflammation, Faculty of Medicine, Vrije Universiteit Van der Boechorststraat, Amsterdam, The Netherlands.
van Kesteren-Hendrikx
Esther
E
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000628:therapy; D004002:Clodronic Acid / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006801:Humans; D007700:Kinetics; D008081:Liposomes / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D016513:Mice, SCID; D009422:Nervous System Diseases / Q000628:therapy; D010587:Phagocytosis; D013601:T-Lymphocytes / Q000378:metabolism
D008081:Liposomes; D004002:Clodronic Acid