Diagnosis and management of Graves' disease.
Graves' disease is characterized by hyperthyroidism, diffuse goitre, ophthalmopathy and, rarely, dermopathy. Although diagnostic testing is straightforward once Graves' disease is suspected, physicians need to be aware of heterogeneous and even atypical presentations of the disease, particularly in elderly patients. Because morbidity may be associated with even subtle forms of hyperthyroidism, treatment promoting long-term euthyroidism is necessary. Although all of the available treatments are effective, compliance is best assured by a full discussion of the risks and benefits of each approach. This review focuses on issues of diagnosis and management that will allow the primary care physician to identify patients with Graves' disease and guide them to recovery.
Ginsberg
Jody
J
Division of Endocrinology and Metabolism, Heritage Medical Research Centre, University of Alberta, Edmonton, AB. jody.ginsberg@ualberta.ca
D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008713:Methimazole / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013960:Thyroid Function Tests
D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D008713:Methimazole