title: Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: case report.
abstract: A 31-year-old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life-threatening disorder. This is the first case report of acquired haemophilia in OHSS.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakauchi-Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sohda
authors.forename: Katsumi
authors.initials: K
authors.lastname: Someya
authors.forename: Keiko
authors.initials: K
authors.lastname: Kono
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D036861:Delivery, Obstetric; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005169:Factor VIII; C065655:anti-inhibitor coagulant complex