title: Is topical nifedipine effective for chronic anal fissures?
abstract: Patients in this study showed remarkable improvement when 1.5% lidocaine and 0.3% nifedipine were applied twice daily for 6 weeks. This extremely safe, well tolerated, and effective treatment should provide family physicians with a reliable nonsurgical method for treating chronic anal fissures.
authors.affiliation: Department of Family Medicine, Georgetown University, Arlington, VA, USA. dmerenstein@yahoo.com
authors.forename: Dan
authors.initials: D
authors.lastname: Merenstein
authors.forename: Dan
authors.initials: D
authors.lastname: Rosenbaum
mesh_terms: D000287:Administration, Topical; D000779:Anesthetics, Local / Q000627:therapeutic use; D002908:Chronic Disease; D004311:Double-Blind Method; D019317:Evidence-Based Medicine; D005401:Fissure in Ano / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D009543:Nifedipine / Q000627:therapeutic use*; D009824:Ointments; D010147:Pain Measurement; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D009824:Ointments; D014665:Vasodilator Agents; D008012:Lidocaine; D009543:Nifedipine