title: [A case of "Takotsubo" cardiomyopathy observed with myocardial scintigraphy from the acute phase].
abstract: A 57-year-old woman was emergently admitted to our hospital because of chest oppression. On examination, blood pressure was 174/96 mmHg, pulse rate was 90/min and coarse crackle and third heart sound were audible. On laboratory data, the levels of LDH and CPK-MB were mildly elevated. Electrocardiogram (ECG) demonstrated elevation of the ST segment in leads I, aVL and V2-V5. 99mTc-tetrofosmin myocardial SPECT (TF) showed severely reduced uptake in the apex and anterior wall. Emergent coronary angiography (CAG) did not show any stenotic lesion. Left ventriculography (LVG), however, demonstrated akinesis of the apex, anterior, and inferior walls, and basal hyperkinesis. On the second hospital day, ECG demonstrated inverted T wave in leads I, aVL and V2-V5. 123I-BMIPP myocardial SPECT (BMIPP) and 123I-MIBG myocardial SPECT (MIBG) were performed on the second and fourth hospital days, respectively. These cardiac images showed severely reduced uptake equally. TF, BMIPP, and MIBG were re-examined on the eighth, tenth, and twelfth hospital days, respectively. MIBG, BMIPP, and TF showed reduced uptake in order of severity. On the fourteenth hospital day, CAG and LVG were re-examined. Coronary vasospasm provocation test was negative using ergonovine and acetylcholine, and LVG did not demonstrated any sign of asynergy. We considered that this case was "Takotsubo" cardiomyopathy and might be caused by microvascular spasm.
authors.affiliation: Department of Cardiology, Murakami Memorial Hospital, Asahi University.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Doue
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ito
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yuba
authors.forename: Takuji
authors.initials: T
authors.lastname: Tanabe
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Adachi
authors.forename: Shuji
authors.initials: S
authors.lastname: Katoh
authors.forename: Akihiro
authors.initials: A
authors.lastname: Azuma
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugihara
authors.forename: Masao
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D019797:3-Iodobenzylguanidine; D000210:Acute-Phase Reaction; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology; D003329:Coronary Vasospasm / Q000150:complications; D005227:Fatty Acids; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008833:Microcirculation; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D019797:3-Iodobenzylguanidine; C078700:technetium tc-99m tetrofosmin