title: Stage IVB uterine endometrial cancer successfully salvaged by chemoradiotherapy and surgery.
abstract: A case of stage IVB adenoacanthoma of the uterine corpus is described. The patient was admitted with a large amount of atypical genital bleeding. Computed tomography and magnetic resonance imaging revealed a large tumor accompanied by lymph node involvement in the left inguinal, multiple pelvic, and paraaortic regions. She was diagnosed as having stage IVB endometrial adenoacanthoma. Neoadjuvant chemotherapy with carboplatin (CBDCA) and 5-fluorouracil (5-FU) was performed, followed by radiotherapy. The tumor responded very well, but still remained in Douglas' pouch after treatment. The patient therefore underwent a simple hysterectomy, pelvic and paraaortic lymphadenectomy, and partial rectal resection. Histopathologically, viable cancer cells were observed only in the fundus of the uterus. The patient is alive with no evidence of recurrence 4 years after the initiation of chemoradiotherapy.
authors.affiliation: Department of Radiology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. kaneyasu@hiroshima-u.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kaneyasu
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Okawa
authors.forename: Masazumi
authors.initials: M
authors.lastname: Yajima
authors.forename: Rie
authors.initials: R
authors.lastname: Saito
authors.forename: Masao
authors.initials: M
authors.lastname: Nakabayashi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Seshimo
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Aomi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Sawada
authors.forename: Norio
authors.initials: N
authors.lastname: Mitsuhashi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging; D008679:Metaplasia / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D016879:Salvage Therapy; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000628:therapy*; D014599:Uterus / Q000473:pathology*
chemical_list: D016190:Carboplatin; D005472:Fluorouracil