A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units.
OBJECTIVE
To study late onset systemic infections with coagulase negative staphylococci.


METHODS
Prospective longitudinal study of coagulase negative staphylococcal infection in 18 Australasian neonatal nurseries.


RESULTS
From 1991 to 2000 inclusive, there were 1281 cases of coagulase negative staphylococcal (CoNS) sepsis, comprising 57.1% of all late onset infections. The male/female ratio was 1.27:1 (p < 0.05). The incidence of CoNS sepsis was 3.46 episodes per 1000 live births. Most infected babies (71%) were 24-29 weeks gestation at birth (mode 26 weeks). The first positive culture was day 7-14 in 49% of babies (mode 10 days). Five cases of meningitis were reported, an incidence of 0.4% of all CoNS infections. Twenty nine babies (2.3%) had concurrent necrotising enterocolitis and CoNS septicaemia. Four babies (0.3%) died from CoNS infection, but CoNS infection possibly contributed to the death of an additional 20 babies (1.6%). The mortality directly attributable to CoNS infection was significantly lower than that from late onset infections with Staphylococcus aureus (13.1%; relative risk (RR) = 36.1 (95% confidence interval (CI) 13.0 to 100.2) or with Gram negative bacilli (14.2%; RR = 45.5 (95% CI 16.8 to 123.3)).


CONCLUSIONS
CoNS are currently responsible for most late onset neonatal infections. Most infected babies are < 30 weeks gestation at birth, and usually present between 7 and 14 days of age. CoNS infections may be associated with necrotising enterocolitis, although causality is unproven. Neonatal CoNS infections are relatively benign: meningitis is rare and mortality low compared with infection from other organisms. Over-vigorous attempts to reduce the incidence of CoNS infections using prophylactic antibiotics are not advisable.
Isaacs
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Department of Immunology and Infectious Diseases, Children's Hospital Westmead, Westmead, NSW 2145, Australia. davidi@chw.edu.au
D001315:Australia / Q000453:epidemiology; D003030:Coagulase / Q000378:metabolism; D003428:Cross Infection / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology*; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013210:Staphylococcus / Q000201:enzymology
D003030:Coagulase