title: Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration.
abstract: Although it is accepted that functional changes of the cortex can occur in patients with white matter diseases of the brain and might have an adaptive role in limiting the clinical consequences of subcortical injury, the pathological substrates able to elicit such cortical changes are still unknown. This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy. massimo.filippi@hsr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.forename: Maria A
authors.initials: MA
authors.lastname: Rocca
authors.forename: Paolo
authors.initials: P
authors.lastname: Rossi
authors.forename: Andrea
authors.initials: A
authors.lastname: Falini
authors.forename: Letizia
authors.initials: L
authors.lastname: Leocani
authors.forename: Vittorio
authors.initials: V
authors.lastname: Martinelli
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Comi
mesh_terms: D002540:Cerebral Cortex / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D009473:Neuronal Plasticity / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology; D012016:Reference Values; D013003:Somatosensory Cortex / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology