title: Diffusion tensor imaging in normal aging and neuropsychiatric disorders.
abstract: The application of diffusion imaging to the quantitative study of the effects of normal aging and neuropsychiatric diseases on brain tissue microstructure has witnessed its greatest development just over the last few years. Measures derived from diffusion imaging have already been shown to have great utility in identifying age- and disease-related degradation of regional microstructure, particularly of white matter. Investigations comparing diagnoses hold promise for contribution to differential diagnosis. Correlations with cognitive and motor performance provide evidence for functional ramifications of these diffusion measures.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Edith V
authors.initials: EV
authors.lastname: Sullivan
authors.forename: Adolf
authors.initials: A
authors.lastname: Pfefferbaum
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D000437:Alcoholism / Q000175:diagnosis / Q000473:pathology; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D015658:HIV Infections / Q000473:pathology; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis / Q000473:pathology