Anchor chain length alters the apparent mechanism of chloride channel function in SCMTR derivatives.
Two membrane-anchored heptapeptides have been prepared and their pore-formation behavior in phospholipid bilayer membranes has been found to differ profoundly as a result only of alkyl chain length.
Schlesinger
Paul H
PH
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Djedovic
Natasha K
NK
Ferdani
Riccardo
R
Pajewska
Jolanta
J
Pajewski
Robert
R
Gokel
George W
GW
D000588:Amines / Q000737:chemistry; D018118:Chloride Channels / Q000138:chemical synthesis* / Q000737:chemistry / Q000502:physiology; D004553:Electric Conductivity; D005452:Fluoresceins; D008081:Liposomes; D008565:Membrane Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000502:physiology; D008567:Membranes, Artificial; D008958:Models, Molecular; D016062:Porosity; D013329:Structure-Activity Relationship
D000588:Amines; D018118:Chloride Channels; D005452:Fluoresceins; D008081:Liposomes; D008565:Membrane Proteins; D008567:Membranes, Artificial; C024098:6-carboxyfluorescein