title: Respiration-induced attenuation artifact at PET/CT: technical considerations.
abstract: Combined positron emission tomographic (PET)/computed tomographic (CT) scanners allow the use of CT data for attenuation correction of PET images. Eight patients with cancer underwent PET/CT scanning. Transmission scanning was performed with conventional attenuation correction and with CT scanning during maximum inspiration and normal expiration. Image quality was visually compared and fluorine 18 activities were measured in volumes of interest in the lung and myocardium. Analysis of variance for repeated measures revealed a significant decrease (P =.0001) in measured activities between PET images corrected with CT data acquired during maximum inspiration and those corrected with the conventional attenuation correction method or with CT data acquired during normal expiration. Deep inspiration during CT can result in severe deterioration in the final PET image.
authors.affiliation: Division of Nuclear Medicine and Department of Biostatistics, University of Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland. gerhard.goerres@dmr.usz.ch
authors.forename: Gerhard W
authors.initials: GW
authors.lastname: Goerres
authors.forename: Cyrill
authors.initials: C
authors.lastname: Burger
authors.forename: Ehab
authors.initials: E
authors.lastname: Kamel
authors.forename: Burkhardt
authors.initials: B
authors.lastname: Seifert
authors.forename: Achim H
authors.initials: AH
authors.lastname: Kaim
authors.forename: Alfred
authors.initials: A
authors.lastname: Buck
authors.forename: Tobias C
authors.initials: TC
authors.lastname: Buehler
authors.forename: Gustav K
authors.initials: GK
authors.lastname: Von Schulthess
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016477:Artifacts; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012119:Respiration; D014055:Tomography, Emission-Computed / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18