title: [Kinetic modeling during continuous hemodiafiltration in patients with sepsis and multiorgan failure].
abstract: Kinetic simulation in terms of urea and creatinine is the best way of prescribing a dialysis dose and assessing its quality as it considers differences in a patient's body weight, the level of catabolism, the rate of equilibration, including the recirculation phenomenon noticeably observed under shock. A 2-pool model of distribution of urea and creatinine was employed in the study. The latter was carried out in 31 patients (17 males and 14 females) with sepsis and multi-organ failure receiving 50 sessions of continuous hemodiafiltration (CHDF). The mean duration of CHDF was 73.8 +/- 7.0 (4.0-207.0) hours, the daily volumes of a substitute, a dialysate, and an effluent (filtrate + dialysate) were 33 +/- 1.0 (5.0-60.0), 43.9 +/- 0.8 (2.6-62.0), and 80.4 +/- 1.6 (12.0-122.3) liters a day, respectively. An analysis confirmed the high efficiency of CHDF close to that of the daily volume-body weight ratio and showed that such conditions of the procedure are optimal in maintaining azotemia at the subnormal level irrespective of the degree of cababolism.
authors.forename: I I
authors.initials: II
authors.lastname: Iakovleva
authors.forename: V S
authors.initials: VS
authors.lastname: Timokhov
authors.forename: L V
authors.initials: LV
authors.lastname: Molchanova
authors.forename: E V
authors.initials: EV
authors.lastname: Pestriakov
authors.forename: V V
authors.initials: VV
authors.lastname: Moroz
authors.forename: O B
authors.initials: OB
authors.lastname: Murav'ev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sergeev
mesh_terms: D003404:Creatinine / Q000097:blood; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology / Q000628:therapy*; D018805:Sepsis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D014508:Urea / Q000097:blood
chemical_list: D014508:Urea; D003404:Creatinine