[Neuropeptide induction of compensatory processes at aphasias].
Dynamic changes of speech function were studied in patients with persistence aphatic disorders after stroke under the conditions of application of V2 vasopressin receptor agonist (1-desamino-8-D-arginin-vasopressin). A course of intranasal administration of the medical drug by using the double blind control showed a reliable reduction of frustration severity of expressive and impressive speech in patients with aphasias of different forms and degrees. A correlation of positive influence of vasopressin on speech, verbal memory and attention was found at efferent motor aphasias. The achieved effects preserved during a two-year catamnestic observation period. A repeated course of therapy resulted in an additional improvement of speech. Neuropeptide restored initially, in patients with aphasias, relatively simple forms of speech and later--complicated ones. This resulted in an improvement of speech functions which are regulated by both cerebral hemispheres. Supposedly, neuropeptide optimized the activity of both the right and left cerebral hemispheres. The stability of the obtained effects is explained by induction, due to vasopressin, of compensatory processes leading to reorganization of intercentral connections.
Belokoskova
S G
SG
Tsikunov
S G
SG
Klement'ev
B I
BI
D000281:Administration, Intranasal; D001037:Aphasia / Q000188:drug therapy* / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002908:Chronic Disease; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D017483:Receptors, Vasopressin / Q000187:drug effects* / Q000378:metabolism*; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*
D006490:Hemostatics; D017483:Receptors, Vasopressin; D014667:Vasopressins