[Effect of traditional Chinese medicine compounds Aining on the expression of apoptosis inducing genes of human gastric cancer cell].
OBJECTIVE
To investigate the effects of Aining on the genes of the human gastric cancer cells.


METHODS
Flow cytometry(FMC) was adopted to detect the gene expression of the gastric cancer cell in the Aining group, the cisplatin(DDP) group and the blank group.


RESULTS
Compared with the blank group, the expression of c-myc and bcl-2 genes was low, while that of the p53, bax genes was high(P < 0.01), and the ratio of bax/bcl-2 significantly increased in both the Aining group and the cisplatin(DDP) group.


CONCLUSIONS
The mechanism of inducing the human gastric cancer cells apoptosis by Aining has some relationship with the changes of the genes.
Su
Miancheng
M
National Engineering Research Center for Mordernization of TCM, Zhuhai 519020.
Dai
Mei
M
Lü
Xiaoying
X
Li
Hongkun
H
Liu
Jilin
J
D017209:Apoptosis / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D008516:Medicine, Chinese Traditional; D013274:Stomach Neoplasms / Q000473:pathology*
D004365:Drugs, Chinese Herbal; D002945:Cisplatin