title: Urodynamic results of sacral neuromodulation correlate with subjective improvement in patients with an overactive bladder.
abstract: OBJECTIVE
  Standard urodynamic investigations showed no correlation between the efficacy of sacral neuromodulation (SNS) and urodynamic data. Ambulant urodynamic investigations (ACM) are presented as more sensitive and reliable in detecting and quantifying bladder overactivity. In this study we looked at the correlation and results of ambulant urodynamic data and the clinical effects of SNS.
  
  
  METHODS
  Data of patients with bladder overactivity, who underwent an ACM before and during SNS were investigated. Blind analyses of the ACM were performed and the detrusor activity index (DAI) was calculated as the degree of bladder overactivity of the detrusor. The ACM parameters, before and during SNS, were analyzed and correlated to the clinical effect of SNS.
  
  
  RESULTS
  In 22 of the 34 patients a DAI before and during stimulation could be calculated because of quality aspects. In all other patients, the other ambulatory urodynamic parameters could be analyzed and a significant reduction was found in bladder overactivity. A significant correlation (p = 0.03) was found in DAI reduction of the ACM before and during SNS as compared to the clinical improvement in overactive bladder symptoms.
  
  
  CONCLUSIONS
  The objective and subjective results show a decrease in bladder overactivity during SNS. During SNS bladder instabilities are still present, which is in accordance with the published literature. The reduction of the DAI during SNS as compared to before SNS correlates significantly to the clinical effect of SNS.
authors.affiliation: Department of Urology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. wa_scheepens@yahoo.com
authors.forename: W A
authors.initials: WA
authors.lastname: Scheepens
authors.forename: G A
authors.initials: GA
authors.lastname: van Koeveringe
authors.forename: R A
authors.initials: RA
authors.lastname: de Bie
authors.forename: E H J
authors.initials: EH
authors.lastname: Weil
authors.forename: Ph E V
authors.initials: PE
authors.lastname: van Kerrebroeck
mesh_terms: D000328:Adult; D000368:Aged; D004558:Electric Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012447:Sacrum; D014555:Urination Disorders / Q000503:physiopathology* / Q000628:therapy*; D014563:Urodynamics / Q000502:physiology*