Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice.
In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.
Zhou
Ping
P
Department of Biology, Georgetown University, Washington, D.C. 20057, USA.
Li
Erqiu
E
Zhu
Nannan
N
Robertson
Jason
J
Nash
Theodore
T
Singer
Steven M
SM
D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D002908:Chronic Disease; D016829:Giardia lamblia / Q000276:immunology; D005873:Giardiasis / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis; D015850:Interleukin-6 / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000032:analysis
D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D015850:Interleukin-6; D012333:RNA, Messenger