[Radioprotective and antineoplastic activity of polyene antibiotics combined with dimethyl sulfoxide].
Radioprotective and antineoplastic activity of polyene, its derivatives and combinations with dimethyl sulfoxide (DMSO) was studied. The most potent radioprotective effect was demonstrated by methylated levorin, original levorin and by its isomer--isolevorin. Survival rate of the animals on 12th day after X-ray exposure was 100, 60, 60 per cent, at the control group 33.6, 20 and 0 per cent consequently. Levorin and alkyl derivatives of amphotericin B--methamphocin and buthamphocin inhibited growth of ascites and solid tumors to 46.3-79.0 per cent when compared to control group. Polyen antibiotics combined with DMSO also demonstrated antineoplastic activity at the animals treated with carcinogenic agent--diethyl nitrosoamine (DENA). 5-month survival of the animals was 76 per cent at nystatin and levorin group and 35.7 per cent at the control group (animals treated with DENA only).
Ibragimova
V Kh
VKh
Radiation Research Department of Azerbaijan Academy of Sciences, Baku.
Aliev
D I
DI
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002174:Candicidin / Q000627:therapeutic use; D004052:Diethylnitrosamine; D004121:Dimethyl Sulfoxide; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D011090:Polyenes / Q000737:chemistry / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D012997:Solvents; D015996:Survival Rate; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011090:Polyenes; D012997:Solvents; D002174:Candicidin; D004052:Diethylnitrosamine; C014624:isolevorin; D000666:Amphotericin B; D004121:Dimethyl Sulfoxide