Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects.
The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. Beta-TCP particles were inserted inside the cylinders and harvested 6 months after placement. The density of the newly formed bone inside the bone-growing chambers measured 27.84% +/- 24.67% in test and 17.90% +/- 4.28% in control subjects, without a statistically significant difference. Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. The present study demonstrates the spontaneous healing of infrabony artificial defects, 2.5 mm diameter, in the jaw. The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation.
Trisi
Paolo
P
Biomaterials Clinical Research Association, Pescara, Italy. paulbioc@tin.it
Rao
Walter
W
Rebaudi
Alberto
A
Fiore
Peter
P
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use*; D015921:Dental Implants; D005500:Follow-Up Studies; D006801:Humans; D008334:Mandible / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology; D013223:Statistics as Topic; D013499:Surface Properties; D014025:Titanium; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; C485817:beta-tricalcium phosphate; D014025:Titanium; C018392:tricalcium phosphate