[Cytokine production during experimental infection of mice with tick-borne encephalitis virus].
An experiment with BALB/c mice, infected with a lethal dosage of the virus of tick-borne encephalitis (TE), strain 205, was accompanied by pronounced growing concentrations of the IL-1 beta, IL-6, IL-10 and TNF alpha cytokines in the blood serum of animals. The maximum values of the above cytokines were determined at the infection terminal stage. A reliably less pronounced growth of concentrations of IL-1 beta, TNF alpha and IL-10 was found in animals infected with a non-lethal TE dosage. The concentration of IL-6 in the blood serum of animals, infected with a non-lethal dosage of the virus, changed during the whole observation period. The dynamics of cytokines in the blood serum of mice, infected with a lethal dosage of the TE virus, suggests the development of SIRS at the infection terminal stage.
Ignat'ev
G M
GM
Otrashevskaia
E V
EV
Vorob'eva
M C
MC
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D004195:Disease Models, Animal; D004669:Encephalitis Viruses, Tick-Borne; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D011933:Reagent Kits, Diagnostic; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D011933:Reagent Kits, Diagnostic; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10