Nanotechnological approaches for the delivery of macromolecules.
In this overview, novel approaches are described for the controlled release and/or for the targeted delivery of macromolecules such as proteins and DNA. The building stones of these highly complex systems are (phospho)lipids and/or (biodegradable) polymers. They should be carefully chosen and preparation protocols should be rationally designed to maximize chances for success.
Crommelin
Daan J A
DJ
Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, Utrecht 3508 TB, The Netherlands. d.j.a.crommelin@pharm.uu.nl
Storm
Gert
G
Jiskoot
Wim
W
Stenekes
Robert
R
Mastrobattista
Enrico
E
Hennink
Wim E
WE
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D046911:Macromolecular Substances; D036103:Nanotechnology / Q000379:methods*
D046911:Macromolecular Substances