title: Enabling parallel protein analysis through mass spectrometry.
abstract: The targets of the majority of drugs on the market and in development are proteins, and the efficient analysis of these molecules is critical to defining targets for better therapeutic intervention. Mass spectrometry is currently the key technology for parallel protein analysis (also referred to as proteomics). In this review we will describe recent advances in mass spectrometry instrumentation, methods and applications that are likely to impact drug discovery.
authors.forename: Bruno
authors.initials: B
authors.lastname: Domon
authors.forename: Kim
authors.initials: K
authors.lastname: Alving
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Terence E
authors.initials: TE
authors.lastname: Ryan
authors.forename: Scott D
authors.initials: SD
authors.lastname: Patterson
mesh_terms: D000818:Animals; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods* / Q000639:trends; D011506:Proteins / Q000032:analysis* / Q000235:genetics*; D040901:Proteomics / Q000379:methods / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D011506:Proteins