title: Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
abstract: Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Sakurai
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Kozuka
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nobukuni
authors.forename: Junko
authors.initials: J
authors.lastname: Takayasu
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Akiko
authors.initials: A
authors.lastname: Kusano
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kusano
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Kuo Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens; D002470:Cell Survival / Q000187:drug effects; D031885:Cimicifuga / Q000737:chemistry; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: C478830:(23R,24S)-16,23-16,24-diepoxy-9,19-cyclolanostan-3beta,15alpha,25-triol; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D007810:Lanosterol; D015127:9,10-Dimethyl-1,2-benzanthracene