title: [A case of hypothalamic hamartoma with refractory seizures: successful treatment with gamma knife surgery].
abstract: Hypothalamic hamartomas are associated with precocious puberty and gelastic epilepsy. The seizures are often refractory to antiepileptic medications. The treatment of hamartoma is not well established. We report a 3-year-6-month-old boy was admitted because of intractable seizures occurring several times a day. The findings on magnetic resonance imaging and his characteristic seizure led to the diagnosis of hypothalamic hamartoma. The seizures were resistant to multiple antiepileptic drugs, and persisted for about 3 years, during which his cognition deteriorated. Focal radiosurgery by a gamma knife of the hamartoma successfully controlled the seizures with no neurological complications, and his mental function improved.
authors.affiliation: Department of Development and Neurology, Kobe Children's Hospital, Kobe.
authors.forename: Wakako
authors.initials: W
authors.lastname: Ogino
authors.forename: Osamu
authors.initials: O
authors.lastname: Soma
mesh_terms: D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000209:etiology; D006222:Hamartoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000601:surgery*; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology; D016634:Radiosurgery; D016896:Treatment Outcome