title: Negative outcome after neurosurgery for refractory obsessive-compulsive spectrum disorder.
abstract: OBJECTIVE
  The authors sought to determine the long-term outcome of patients with severe and refractory obsessive-compulsive disorder spectrum (OCDS) following neurosurgery.
  
  
  METHODS
  Five patients who underwent neurosurgery as a last-resort treatment for refractory OCDS were evaluated. On all patients, posttest data was obtained from the Yale-Brown Obsessive-Compulsive Scale, The Overvalued Ideas Scale, the Beck Depression Inventory and the Beck Anxiety Inventory. Pretest scores were available on three patients as well.
  
  
  RESULTS
  All patients failed to maintain initial improvements after surgery and relapsed. In addition, they became depressed with suicidal ideation or attempt.
  
  
  CONCLUSIONS
  Complications of neurosurgery are discussed, notably relapse and depression.
authors.affiliation: Bio-Behavioral Institute, Department of Biopsychosocial Research, 935 Northern Blvd, Suite 102, Great Neck, NY 11021, USA. biobehavny@ibbtr.com
authors.forename: J A
authors.initials: JA
authors.lastname: Yaryura-Tobias
authors.forename: K P
authors.initials: KP
authors.lastname: Stevens
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Rivera
authors.forename: O E
authors.initials: OE
authors.lastname: Boullosa
authors.forename: F
authors.initials: F
authors.lastname: Neziroglu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000601:surgery*; D011183:Postoperative Complications; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome