title: Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats.
abstract: We investigated the cellular distribution of three calcium sensor proteins, visinin-like protein-1 (VILIP-1), VILIP-3, and hippocalcin, in different rat brain areas after repeated administration of the non-competitive N-methyl-D-aspartate receptor antagonist ketamine. In comparison to controls we observed an increase in the density of VILIP-1 immunoreactive (IR) hippocampal interneurons and presubicular nerve cells in ketamine treated rats, whereas the density of VILIP-1 expressing cells was decreased in the Nuc. accumbens of these rats. No alterations were seen in the distribution patterns of VILIP-3. The density of hippocalcin-expressing neurons was increased in the cingulate cortex of drug-treated rats. Our experiments show that repeated injections of subanesthetic doses of ketamine induce subtle changes in the cellular distribution of calcium sensor proteins which in part resemble those recently described in postmortem brains of human schizophrenics [Bernstein, H.-G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396].
authors.affiliation: Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D-39120, Magdeburg, Germany. hans-gert.bernstein@medizin.uni-magdeburg.de
authors.forename: Hans-Gert
authors.initials: HG
authors.lastname: Bernstein
authors.forename: Axel
authors.initials: A
authors.lastname: Becker
authors.forename: Gerburg
authors.initials: G
authors.lastname: Keilhoff
authors.forename: Christina
authors.initials: C
authors.lastname: Spilker
authors.forename: Wojiech A
authors.initials: WA
authors.lastname: Gorczyca
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Braunewell
authors.forename: Gisela
authors.initials: G
authors.lastname: Grecksch
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D018691:Excitatory Amino Acid Antagonists; D051597:Hippocalcin; D007150:Immunohistochemistry; D007649:Ketamine; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051596:Neurocalcin; D009928:Organ Specificity; D051381:Rats; D017207:Rats, Sprague-Dawley; D044169:Receptors, Calcium-Sensing
chemical_list: D002135:Calcium-Binding Proteins; D018691:Excitatory Amino Acid Antagonists; C496693:Hpca protein, rat; C469810:Hpcal1 protein, rat; D009419:Nerve Tissue Proteins; D051596:Neurocalcin; D044169:Receptors, Calcium-Sensing; C496690:Vsnl1 protein, rat; D051597:Hippocalcin; D007649:Ketamine