Membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib.
Both membranous glomerulopathy and acute interstitial nephritis have been reported to occur following treatment with non-steroidal anti-inflammatory drugs. We report the first cases of membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib (Celebrex), a selective COX-2 inhibitor. The rapid and complete resolution of both conditions following discontinuation of Celebrex strongly implicates this agent in disease pathogenesis. These cases enlarge the spectrum of potential renal toxicities of the COX-2-specific non-steroidal anti-inflammatory drugs.
Markowitz
G S
GS
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Falkowitz
D C
DC
Isom
R
R
Zaki
M
M
Imaizumi
S
S
Appel
G B
GB
D'Agati
V D
VD
D000208:Acute Disease; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D000068579:Celecoxib; D005260:Female; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D010003:Osteoarthritis / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib; D011241:Prednisone