title: Effect of retinoic acid treatment on cytogenetic remission of chronic myeloid leukaemia.
abstract: The cytogenetic responses during the first chronic phase of 11 patients with chronic myeloid leukaemia (CML) treated with all-trans retinoic acid (ATRA) + interferon (IFN) were compared with those of 9 other CML patients treated with IFN alone. Metaphase and interphase cytogenetics and a semi-quantitative polymerase chain reaction were used to evaluate the cytogenetic responses. Two of the 11 patients in the ATRA + IFN group were withdrawn, one of them because of IFN intolerance, and the other because of non-compliance. Of the 9 remaining ATRA + IFN-treated patients 6 exhibited major cytogenetic responses, 3 of which were complete. Of the 9 patients treated with IFN alone, only 2 showed major cytogenetic responses. No severe adverse effects were observed. The preliminary results suggest that the ATRA + IFN combination may be superior in achieving cytogenetic remission in the first chronic phase of CML.
authors.affiliation: Department of Internal Medicine, Kaposi Mór County Hospital, Kaposvár, Hungary. egyedmiklos@yahoo.com
authors.forename: Miklós
authors.initials: M
authors.lastname: Egyed
authors.forename: Balázs
authors.initials: B
authors.lastname: Kollár
authors.forename: György
authors.initials: G
authors.lastname: Rumi
authors.forename: Eva
authors.initials: E
authors.lastname: Keller
authors.forename: János
authors.initials: J
authors.lastname: Vass
authors.forename: Sándorné
authors.initials: S
authors.lastname: Fekete
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012008:Recurrence; D012074:Remission Induction; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014212:Tretinoin