title: Marked improvement of left ventricular function after parathyroidectomy in a hemodialysis patient with secondary hyperparathyroidism and left ventricular dysfunction.
abstract: A 52-year-old woman, a hemodialysis patient, was admitted because of exertional dyspnea. Echocardiography showed left ventricular (LV) dilatation and reduced contraction. Coronary angiography showed no fixed stenosis. She had elevated levels of parathyroid hormone (PTH) as a result of secondary hyperparathyroidism with advanced renal failure. After parathyroidectomy, marked improvement of LV function following immediate decrease of blood levels of PTH was observed. It is suggested that PTH might have a significant role in the pathogenesis of LV dysfunction and that parathyroidectomy might be effective as a therapy for heart failure in some patients with secondary hyperparathyroidism and LV dysfunction.
authors.affiliation: Department of Cardiology, Osaka City General Hospital, Japan. douki@sm.rim.or.jp
authors.forename: Michitaka
authors.initials: M
authors.lastname: Nagashima
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Takuro
authors.initials: T
authors.lastname: Shinsato
authors.forename: Kinya
authors.initials: K
authors.lastname: Ashida
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamashita
authors.forename: Masato
authors.initials: M
authors.lastname: Otsuka
authors.forename: Takahiko
authors.initials: T
authors.lastname: Naruko
authors.forename: Akira
authors.initials: A
authors.lastname: Itoh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Haze
mesh_terms: D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000209:etiology / Q000601:surgery; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology; D016105:Parathyroidectomy; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications* / Q000628:therapy; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000628:therapy; D016277:Ventricular Function, Left
chemical_list: D010281:Parathyroid Hormone