title: Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.
abstract: We describe the isolation and spectrometric structure elucidation of eight new xanthones, fuscaxanthone A (1), B (2), C (3), D (4), E (5), F (6), G (7), and H (8), together with eight known xanthones from the stem bark of Garcinia fusca collected in Thailand. All the new xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules. We also present the results of a primary screening of the inhibitory effects of eight xanthones (9-16) isolated as major components of this plant on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
authors.affiliation: Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takakura
authors.forename: Nijisiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Fumio
authors.initials: F
authors.lastname: Enjo
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000956:Antigens, Viral; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013785:Thailand; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D014966:Xanthenes