title: Steroid control of longevity in Drosophila melanogaster.
abstract: Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.
authors.affiliation: Division of Biology 156-29, California Institute of Technology, 1201 California Boulevard, Pasadena, CA 91125, USA.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Simon
authors.forename: Cindy
authors.initials: C
authors.lastname: Shih
authors.forename: Antha
authors.initials: A
authors.lastname: Mack
authors.forename: Seymour
authors.initials: S
authors.lastname: Benzer
mesh_terms: D000818:Animals; D001835:Body Weight; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D004440:Ecdysone / Q000096:biosynthesis / Q000502:physiology*; D004441:Ecdysterone / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005298:Fertility; D017344:Genes, Insect; D008024:Ligands; D008136:Longevity; D008297:Male; D009154:Mutation; D018384:Oxidative Stress; D018524:Phototropism; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D013217:Starvation; D013696:Temperature
chemical_list: D008024:Ligands; D011987:Receptors, Steroid; C055469:ecdysone receptor; D004440:Ecdysone; D004441:Ecdysterone