Morphological correlates of immune-mediated peripheral opioid analgesia.
The immune system is a source of opioid peptides and plays an important role in the control of inflammatory pain. Inflammation not only increases the opioid receptor expression in DRG neurons but also enhances transport and accumulation of opioid receptors on the peripheral terminals of sensory neurons. Immune cells containing opioid peptides migrate to the inflamed tissue. This is orchestrated by adhesion molecules up-regulated on vessel endothelia and co-expressed by opioid-containing immunocytes. The peptides are secreted by stressful stimuli, CRF and cytokines and the corresponding receptors are present on opioid-expressing leukocytes. The opioids bind to their receptors localized on peripheral sensory nerves leading to pain inhibion. In the more distant future, these findings might stimulate the development of novel analgesics based on enhancing the transport and release of immune-derived opioid peptides into injured tissue.
Mousa
Shaaban A
SA
Klinik für Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universität Berlin, Germany.
D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D007375:Interleukin-1 / Q000502:physiology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology; D015213:Neuroimmunomodulation / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000187:drug effects / Q000502:physiology; D017472:Receptors, Interleukin-1 / Q000187:drug effects / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology
D000701:Analgesics, Opioid; D015815:Cell Adhesion Molecules; D007375:Interleukin-1; D009419:Nerve Tissue Proteins; D018019:Receptors, Corticotropin-Releasing Hormone; D017472:Receptors, Interleukin-1; D011957:Receptors, Opioid; D011333:Pro-Opiomelanocortin; D003346:Corticotropin-Releasing Hormone