Investigation of physical and hypoglycaemic properties of rectal suppositories with chosen insulin.
Rectal suppositories with insulin Humulin M3 (30/70) were prepared. Witepsol H15 and a polyoxyethyleneglycol mixture, composed of PEG 400, PEG 1000 and PEG 6000, were used as bases. Tween 60 and sodium salicylate were used as auxiliary substances. Hypoglycaemic properties of the prepared suppositories were tested on rabbits. The obtained results were compared with the data acquired after intravenous administration of insulin and subcutaneous injection of insulin.
Kosior
Anna
A
Department of Pharmacy, School of Medicine, 12 Peowiaków Str., 20-007 Lublin, Poland.
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D013488:Suppositories / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013488:Suppositories