title: Severe Raynaud's phenomenon with chronic hepatis C disease treated with interferon.
abstract: Severe Raynaud's phenomenon developed in a 5-year-old girl with chronic hepatitis C infection at the fifth month of interferon therapy in the absence of cryoglobulinemia and other conditions commonly associated with secondary Raynaud's phenomenon. Although interferon therapy was promptly discontinued, Raynaud's phenomenon persisted for 4 months with appearance of necrotic-ulcerous lesions at the tips of fingers.
authors.affiliation: Department of Pediatrics, University of Naples Federico II, Italy. riorio@unina.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Iorio
authors.forename: Maria Immacolata
authors.initials: MI
authors.lastname: Spagnuolo
authors.forename: Angela
authors.initials: A
authors.lastname: Sepe
authors.forename: Stefania
authors.initials: S
authors.lastname: Zoccali
authors.forename: Maria
authors.initials: M
authors.lastname: Alessio
authors.forename: Angela
authors.initials: A
authors.lastname: Vegnente
mesh_terms: D001774:Blood Chemical Analysis; D002675:Child, Preschool; D003449:Cryoglobulinemia; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D011928:Raynaud Disease / Q000139:chemically induced* / Q000175:diagnosis*; D011994:Recombinant Proteins; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D018608:Ultrasonography, Doppler
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins