Indonesian medicinal plants. XXV. Cancer cell invasion inhibitory effects of chemical constituents in the parasitic plant Scurrula atropurpurea (Loranthaceae).
Six fatty acids (1-6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13-16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-triynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (-)-epicatechin (14), (-)-epicatechin-3-O-gallate (15) and (-)-epigallocatechin-3-O-gallate (16)].
Ohashi
Kazuyoshi
K
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
Winarno
Hendig
H
Mukai
Mutsuko
M
Inoue
Masahiro
M
Prana
Made Sri
MS
Simanjuntak
Partomuan
P
Shibuya
Hirotaka
H
D000818:Animals; D028241:Camellia sinensis; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007214:Indonesia; D028183:Loranthaceae; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems; D010946:Plants, Medicinal; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010936:Plant Extracts