title: Prospective clinical evaluation of the serologic tuberculous glycolipid test in combination with the nucleic acid amplification test.
abstract: We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions.
authors.affiliation: Toneyama National Hospital, Osaka, Japan. maekurat@toneyama@toneyama.hosp.go.jp
authors.forename: Ryoji
authors.initials: R
authors.lastname: Maekura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kohno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirotani
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Okuda
authors.forename: Masami
authors.initials: M
authors.lastname: Ito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ogura
authors.forename: Ikuya
authors.initials: I
authors.lastname: Yano
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques; D011446:Prospective Studies; D012698:Serologic Tests; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*
chemical_list: D004269:DNA, Bacterial; D006017:Glycolipids