title: Spontaneous nontraumatic intrasplenic pseudoaneurysm: causes, sonographic diagnosis, and prognosis.
abstract: OBJECTIVE
  The aim of this study was to describe the incidence, causes, sonographic features, therapy, and prognosis of nontraumatic intrasplenic pseudoaneurysms (NTISPs), a rare complication of splenic infarction or infiltration by malignant systemic disorders or infectious diseases.
  
  
  METHODS
  We retrospectively reviewed the medical and sonographic records of all patients seen at our clinic from July 1985 through December 2000 to identify patients with a sonographic diagnosis of spontaneous nontraumatic splenic rupture. We then examined the features of the resulting cases to identify patients in whom NTISPs were revealed by color Doppler sonography.
  
  
  RESULTS
  In total, 41 patients were identified. Among those patients, 5 (12%) had NTISPs. Three of those 5 patients had an underlying malignant disorder (1 case of non-Hodgkin's lymphoma and 2 cases of chronic myelogenous leukemia), and the other 2 had an inflammatory disease (1 case of endocarditis and 1 case of pancreatitis). Three of the patients also had splenic infarctions. Three patients underwent splenectomy; in 2 of them, secondary delayed splenic rupture occurred before or during splenectomy. In 2 other patients, spontaneous thrombosis of the aneurysms occurred (after 16 hours in 1 and 15 days in the other).
  
  
  CONCLUSIONS
  NTISPs may occur in about 12% of patients with sonographically detected nontraumatic spontaneous splenic rupture. NTISPs appear to be associated with an increased risk of secondary delayed splenic rupture, although spontaneous thrombosis may occur. Short-term follow-up sonographic examinations, particularly with color Doppler imaging, are recommended for early recognition of progression of NTISPs, which can guide treatment decisions.
authors.affiliation: Department of Internal Medicine, Philipps University, Baldingerstrasse, 35043 Marburg/Lahn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Görg
authors.forename: Julia
authors.initials: J
authors.lastname: Cölle
authors.forename: Mathias
authors.initials: M
authors.lastname: Wied
authors.forename: Wolf B
authors.initials: WB
authors.lastname: Schwerk
authors.forename: Gerhard
authors.initials: G
authors.lastname: Zugmaier
mesh_terms: D017541:Aneurysm, False / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012422:Rupture, Spontaneous / Q000000981:diagnostic imaging; D013157:Splenic Artery / Q000000981:diagnostic imaging; D013159:Splenic Infarction / Q000150:complications / Q000000981:diagnostic imaging; D013161:Splenic Rupture / Q000150:complications / Q000000981:diagnostic imaging; D018615:Ultrasonography, Doppler, Color