title: The various and varying roles of specific chaperones in type III secretion systems.
abstract: The type III secretion pathway is used by numerous Gram-negative pathogenic bacteria to deliver proteins within the membrane or the cytoplasm of eukaryotic cells with which these bacteria interact. Secretion is regulated by external signals. This requires that, before being secreted, proteins are stored in the cytoplasm where they need to be stabilised, separated from other interaction partners, and maintained in a secretion-competent state. Specialised, energy-independent chaperones play various roles in these functions by associating in the cytoplasm with proteins before their secretion. Some chaperones are also directly involved in modulating transcription in response to secretion.
authors.affiliation: Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. cparsot@pasteur.fr
authors.forename: Claude
authors.initials: C
authors.lastname: Parsot
authors.forename: Cyril
authors.initials: C
authors.lastname: Hamiaux
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Page
mesh_terms: D001665:Binding Sites; D005407:Flagella / Q000502:physiology; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000378:metabolism*; D018832:Molecular Chaperones / Q000145:classification / Q000502:physiology*; D015394:Molecular Structure; D021381:Protein Transport; D014158:Transcription, Genetic
chemical_list: D018832:Molecular Chaperones