Unusual aberration involving the short arm of chromosome 11 in an 8-month-old patient with a supratentorial primitive neuroectodermal tumor.
An 8-month-old baby girl with a supratentorial primitive neuroectodermal tumor showed an unusual aberration involving the short arm of chromosome 11. Seven abnormal metaphase cells had 49 chromosomes with trisomies of chromosomes 9 and 13, and partial trisomies of 1q and 18p. One homologue chromosome 11 was strikingly abnormal showing a long acrocentric-like form, which was composed of the long arm of chromosome 1 and an addition to the short arm of chromosome 11. This was characterized by fluorescence in situ hybridization using a partial arm chromosome-painting probe.
Batanian
Jacqueline R
JR
Department of Pediatrics, Cardinal Glennon Children's Hospital, St. Louis, MO 63104, USA. batanijr@slu.edu
Havlioglu
Necat
N
Huang
Yufeng
Y
Gadre
Bharti
B
D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D018242:Neuroectodermal Tumors, Primitive / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D015173:Supratentorial Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology