title: Indonesian medicinal plants. XXV. Cancer cell invasion inhibitory effects of chemical constituents in the parasitic plant Scurrula atropurpurea (Loranthaceae).
abstract: Six fatty acids (1-6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13-16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-triynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (-)-epicatechin (14), (-)-epicatechin-3-O-gallate (15) and (-)-epigallocatechin-3-O-gallate (16)].
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Hendig
authors.initials: H
authors.lastname: Winarno
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Mukai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Made Sri
authors.initials: MS
authors.lastname: Prana
authors.forename: Partomuan
authors.initials: P
authors.lastname: Simanjuntak
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D028241:Camellia sinensis; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007214:Indonesia; D028183:Loranthaceae; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems; D010946:Plants, Medicinal; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D010936:Plant Extracts