[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases].
Several studies indicate a possible association between different genes and chronic neurodegenerative diseases including Alzheimer's disease (DTA). To further investigate, we have analyzed association between the apolipoprotein E (apo E) and bleomycin hydrolase (BH) polymorphisms and three groups of elderly patients: control subjects (T) (n = 68), late-onset sporadic DTA patients (DTAst) (n = 65) and other non vascular neurodegerative diseases (MNDA) (n = 52). Apo E-epsilon4 and BH-G alleles frequencies (%) are: 8.2 (T), 31.5 (DTAst), 16.4 (MNDA) and 41.4 (T), 35.6 (DTAst). No association has been observed between carrying the G allele and DTA in epsilon4 negative subjects but, our data have confirmed the earlier reports: carrying the epsilon4 allele is a dose-dependent risk factor for the DTAst (OR: 6.0, IC 95 %: 2.6-13.7) and decrease the age of symptom onset (p < 0.005). They have also suggested that apo E genotyping may be of interest to perform differential diagnosis of neurodegenerative diseases in elderly subjects.
Nivet-Antoine
V
V
Laboratoire de biochimie, Hôpital Charles Foix, Ivry-sur-Seine.
Coulhon
M-P
MP
Le Denmat
C
C
Hamon
B
B
Dulcire
X
X
Lefebvre
M
M
Piette
F
F
Davous
P
P
Durand
D
D
Duchassaing
D
D
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D003546:Cysteine Endopeptidases / Q000235:genetics*; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D015203:Reproducibility of Results
D001057:Apolipoproteins E; D017931:DNA Primers; D003546:Cysteine Endopeptidases; C031262:bleomycin hydrolase