title: [Study on extraction of active ingredients from Andrographis paniculatal using the orthogonal experiment with supercritical carbon dioxide].
abstract: This paper studied the extraction technology of active ingredients from Andrographis paniculatal using the orthogonal experiment with supercritical CO2. The active ingredients of this extract had higher purity and more stable quality than those came from conventional extract technology. And the target ingredients, dehydrated andrographolidume and andrographolidume, had higher content. Furthermore this method had shorter technology process and saved a great deal of solvent than conventional ethanol extraction, which was exactly suitable for industrialization manufacture. The optimization condition was: extractor pressure 25 MPa, extractor temperature 46 degrees C, separator I pressure 6 MPa, separator I temperature 65 degrees C, separator II pressure 6 MPa, separator II temperature 45 degrees C, CO2 rate of flow 40 kg/h.
authors.affiliation: Guangzhou Jianyuan Traditional Chinese Medicine Science and Technology Industrial Co. Ltd., Guangzhou 510240.
authors.forename: Fahuan
authors.initials: F
authors.lastname: Ge
authors.forename: Xiuxian
authors.initials: X
authors.lastname: Lin
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Huan
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Shi
authors.forename: Baozuan
authors.initials: B
authors.lastname: Liang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Guanghua
authors.initials: G
authors.lastname: Zhong
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D002245:Carbon Dioxide; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D004224:Diterpenes / Q000032:analysis*; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D002245:Carbon Dioxide; C030419:andrographolide