Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: case report.
A 31-year-old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life-threatening disorder. This is the first case report of acquired haemophilia in OHSS.
Nakauchi-Tanaka
Tomoko
T
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan.
Sohda
Satoshi
S
Someya
Katsumi
K
Kono
Keiko
K
Hamada
Hiromi
H
Yoshikawa
Hiroyuki
H
D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D036861:Delivery, Obstetric; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000378:metabolism*; D011247:Pregnancy
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005169:Factor VIII; C065655:anti-inhibitor coagulant complex