title: MUC-1 mucin protein expression in B-cell lymphomas.
abstract: We have recently shown that MUC1, mapped to the chromosomal band 1q21, is rearranged or amplified in 15% of B-cell lymphomas and that rearrangement led to over-expression of MUC-1 mucin in a case of diffuse large B-cell lymphoma (DLBCL). To determine the incidence of MUC-1 mucin expression and its clinical significance in B-cell lymphomas, we investigated a panel of 113 cases by immunohistochemistry (IHC). MUC-1 mucin expression was detected in the majority of cases (92.9%), with moderate to high levels noted in 50.4% of all histologic subsets comprising DLBCL (82 cases), follicular lymphoma (FL) (15 cases), FL with transformation to DLBCL (4 cases), and other B-cell lymphomas (12 cases). No statistically significant correlation was found between MUC-1 mucin expression and MUC1 genomic status (amplification/rearrangement) evaluated by Southern blot analysis, and 1q21 abnormality by karyotypic analysis. For all cases, MUC-1 mucin expression correlated with a previous history of lymphoma (p=0.003).
authors.affiliation: Department of Pathology, Cell Biology and Immunology Programs, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. feldstej@mskcc.org
authors.forename: Julie
authors.initials: J
authors.lastname: Teruya-Feldstein
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Donnelly
authors.forename: Andre
authors.initials: A
authors.lastname: Goy
authors.forename: Abhijith
authors.initials: A
authors.lastname: Hegde
authors.forename: Gouri
authors.initials: G
authors.lastname: Nanjangud
authors.forename: Jing
authors.initials: J
authors.lastname: Qin
authors.forename: Howard
authors.initials: H
authors.lastname: Thaler
authors.forename: Frederic
authors.initials: F
authors.lastname: Gilles
authors.forename: Vadim G
authors.initials: VG
authors.lastname: Dyomin
authors.forename: Kenneth O
authors.initials: KO
authors.lastname: Lloyd
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Zelenetz
authors.forename: Jane
authors.initials: J
authors.lastname: Houldsworth
authors.forename: R S K
authors.initials: RS
authors.lastname: Chaganti
mesh_terms: D015139:Blotting, Southern; D015331:Cohort Studies; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000378:metabolism*; D018396:Mucin-1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D018396:Mucin-1