[Experimental study of the effect of glucosamine hydrochloride on metabolic and repair processes in connective tissue structures].
The effects of glucosamine hydrochloride on the metabolic and repair processes were studied on a model of post-traumatic osteoarthrosis in the articular cartilage and on a model of post-traumatic keratitis in the cornea. The administration of glucosamine hydrochloride stimulated repair and favored inhibition of dystrophic post-traumatic processes in the connective-tissue structures. It is suggested that a probable mechanism of the drug action consists in stimulation of the synthesis of glucosaminoglycanes and collagen.
Zupanets
I A
IA
Clinical Pharmacy Department, National Pharmaceutical Academy of Ukraine, ul. Pushkinskaya 53, Kharkov 61002, Ukraine.
Bezdetko
N V
NV
Dedukh
N V
NV
Otrishko
I A
IA
D000818:Animals; D003238:Connective Tissue / Q000293:injuries* / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism; D005944:Glucosamine / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000378:metabolism; D007634:Keratitis / Q000209:etiology / Q000378:metabolism; D015207:Osteoarthritis, Hip / Q000209:etiology / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D006025:Glycosaminoglycans; D005944:Glucosamine