Factor analysis of treatment response in posttraumatic stress disorder.
Factor analysis is applied to the symptoms of posttraumatic stress disorder (PTSD) to reduce the multidimensional symptom space to 2 dimensions; 1 dimension strongly correlated with depressive symptoms and 1 independent dimension weakly correlated with depressive symptoms. These factors are used to assess whether the effectiveness of an antidepressant medication is due to its antidepressant effect. The treatment is shown to be effective in both dimensions. The factor analysis sheds light on the symptom structure of PTSD, supports PTSD as a distinct psychiatric disorder, and supports the current diagnostic criteria.
Gaffney
Michael
M
Pfizer Inc., 235 East 42nd Street, New York, New York 10017, USA. michael.gaffney@pfizer.com
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D004311:Double-Blind Method; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000628:therapy*; D016896:Treatment Outcome
D000928:Antidepressive Agents; D010919:Placebos