title: Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis.
abstract: OBJECTIVE
  To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA).
  
  
  METHODS
  Genotyping for these IL-2 variants was performed by a polymerase chain reaction restriction fragment length polymorphism method in 174 RA patients and 153 control individuals.
  
  
  RESULTS
  No statistically significant differences were observed when the -384 and 114 IL-2 genotype distributions between RA patients and healthy controls were compared. In addition, no association was found between the IL-2 genotypes with any demographic and clinical variables tested.
  
  
  CONCLUSIONS
  Our results provide no evidence for genetic association conferred by the -384 and 114 IL-2 SNP with respect to susceptibility and severity of RA.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Fedetz
authors.forename: Fuencisla
authors.initials: F
authors.lastname: Matesanz
authors.forename: Rafael
authors.initials: R
authors.lastname: Cáliz
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Ferrer
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Collado
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcina
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012720:Severity of Illness Index
chemical_list: D007376:Interleukin-2