Preliminary studies on Alzheimer's disease using cDNA microarrays.
Alzheimer's disease (AD) is characterized by a progressive impairment of memory and intellectual functioning. The disease is a complex multi-factorial disease with the involvement of several possible genes. To study AD, a high-density cDNA array was developed to characterize the mRNA expression profile of 14160 genes. The preliminary results support the amyloid cascade hypothesis as the mechanism of the disease.
Wang
Guoqing
G
Department of Biological Science and Biotechnology, Tsinghua University, 100084, Beijing, PR China.
Zhang
Yan
Y
Chen
Biao
B
Cheng
Jing
J
D000429:Alcohol Oxidoreductases; D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D000682:Amyloid / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics; D015536:Down-Regulation; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010750:Phosphoproteins / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics; D015854:Up-Regulation
D000682:Amyloid; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D016212:Transforming Growth Factor beta; D000429:Alcohol Oxidoreductases; C096794:C-terminal binding protein