title: Expression of gamma-adducin is associated with regions of morphogenetic cell movement in the chick embryo.
abstract: The adducin family of cytoskeletal proteins are known to mediate actin driven cell movements. Here we describe the cloning and expression pattern of a gene encoding gamma-adducin in the chick embryo. Expression of this gene is strikingly restricted to the epithelial cell layer (with a few exceptions including emerging notochord and lateral mesoderm). Gamma-adducin is detected at particularly high levels in cell populations undergoing important morphogenetic movements, such as epiblast approaching the primitive streak, regressing spinal cord primordia and closing neural tube.
authors.affiliation: Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
authors.forename: Jun
authors.initials: J
authors.lastname: Akai
authors.forename: Kate
authors.initials: K
authors.lastname: Storey
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D002642:Chick Embryo; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D009928:Organ Specificity; D016415:Sequence Alignment; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D000099291:Adducins