[Seromuscular colocystoplasty lined by urothelium. Experimental study in rats].
OBJECTIVE
To determine what technical of vesical extension in rat can offer the best functional and histological results.


METHODS
Comparative experimental study between pre and postoperative parameters of 60 female Wistar rats. The animals were divided in 5 groups using different techniques of vesical augmentation. Sham, colocystoplasty (CC), demucosalised colocystoplasty (DCC), demucosalised colocystoplasty lined by urothelium (AADCC), autoaugmentation (AA).


METHODS
Preoperative cystometrical study. Microsurgery for vesical augmentation. New cystometric study at the month, previous to the sacrifice of the animal and extraction of bladder for its histological study. Measurement of the volume and pressure of rupture.


RESULTS
The technique of seromuscular enterocistoplasty presents the high mortality in the rat (63.6%). The increase of the vesical volume in both groups that carried seromuscular grafts was little (0.22 +/- 0.5 and 0.47 +/- 0.3 ml) in front of the control group (0.11 +/- 0.4 ml). Only standard colocystoplasty and bladder autoaugmentation produced significant increases on vesical volume (0.78 +/- 0.5 and 0.69 +/- 0.6 ml, respectively) and rupture volume. There were not observed significant differences on vesical rupture pressure.
Blanco Bruned
J L
JL
Servicio de Cirugía Pediátrica, Hospital de Cruces, Baracaldo, Vizcaya.
Alvarez Díaz
J F
JF
Sáez López
A
A
Oliver Llinares
F
F
Prado Fernández
C
C
González Landa
G
G
D000818:Animals; D003106:Colon / Q000473:pathology / Q000637:transplantation*; D005260:Female; D009130:Muscle, Smooth / Q000473:pathology / Q000637:transplantation; D051381:Rats; D017208:Rats, Wistar; D012704:Serous Membrane / Q000473:pathology / Q000637:transplantation; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery*; D019459:Urothelium / Q000473:pathology / Q000637:transplantation*