title: NF-kappaB dependent activation of human endothelial cells treated with soluble products derived from human lymphomas.
abstract: Nuclear factor of the Immunoglobulin Kappa chain of B cells (NF-kappaB) activation is an early event during cytokine-mediated endothelial activation related to increased adhesion of leucocytes. We report that soluble products secreted by two human lymphomas activate NF-kappaB, and increase the ability of endothelial cells to adhere U937 cells in vitro. Analysis of the tumor-derived products revealed the absence of tumor necrosis factor-alpha and interleukin-1beta. Interference of NF-kappaB activation prevented the increase in U937 cell adhesion, suggesting a potential role for endothelial NF-kappaB activation in the establishment of physical interactions between the vascular endothelium and tumor cells.
authors.affiliation: Departamento de Biología Celular del Instituto de Fisiología Celular UNAM, Copilco Universidad, PO Box 70-243, Mexico DF 04510, Mexico. aestrada@ifisiol.unam.mx
authors.forename: Adriana
authors.initials: A
authors.lastname: Estrada-Bernal
authors.forename: Criselda
authors.initials: C
authors.lastname: Mendoza-Milla
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ventura-Gallegos
authors.forename: Lucia Nikolaia
authors.initials: LN
authors.lastname: López-Bojórquez
authors.forename: Enrique
authors.initials: E
authors.lastname: Miranda-Peralta
authors.forename: Fabián
authors.initials: F
authors.lastname: Arechavaleta-Velasco
authors.forename: Felipe
authors.initials: F
authors.lastname: Vadillo-Ortega
authors.forename: Luis
authors.initials: L
authors.lastname: Sánchez-Sánchez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zentella-Dehesa
mesh_terms: D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D020298:U937 Cells
chemical_list: D007375:Interleukin-1; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha