title: Differentiation of soft tissue haemangioma by 201Tl scintigraphy.
abstract: Radiological diagnosis of deep soft tissue is often difficult. In the present study, thallium-201 ( Tl) uptake into haemangiomas and deep malignant soft tissue tumours was investigated in order to assess its clinical utility. Tl scintigraphy was reviewed in four patients presenting with soft tissue haemangiomas. Early and delayed planar images, obtained at 15 min and 3 h following the intravenous injection of Tl (111 MBq), were examined. The Tl uptake ratio was calculated by dividing the count density of the tumour region of interest (ROI) by that of the background ROI. Results were compared with those of five cases of rhabdomyosarcoma and a single instance of angiosarcoma. All haemangioma lesions demonstrated increased Tl uptake in early images. However, Tl uptake in delayed images was markedly decreased. No significant differences were observed in the early uptake ratio between haemangiomas (1.60-2.72) and reference malignant tumours (1.48-2.45); however, the difference was significant in delayed images (range, 1.01-1.26 vs. 1.43-2.03, respectively) ( P<0.02). Deep soft tissue haemangiomas revealed Tl accumulation in early images; however, a rapid washout was observed in delayed images. This distinctive feature may facilitate the use of Tl scintigraphy in the diagnosis of haemangiomas.
authors.affiliation: Department of Nuclear Medicine, Kanazawa University School of Medicine, Kanazawa Cardiovascular Hospital, Kanazawa, Japan. higuchi@med.kanazawa-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: J
authors.initials: J
authors.lastname: Taki
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Kinuya
authors.forename: A
authors.initials: A
authors.lastname: Nonomura
authors.forename: H
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Bunko
authors.forename: M
authors.initials: M
authors.lastname: Namura
authors.forename: N
authors.initials: N
authors.lastname: Tonami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000378:metabolism; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D013794:Thallium Radioisotopes