Aminoalkoxide-mediated formation and stabilization of phenylpyridyllithium: straightforward access to phenylpyridine derivatives.
It is shown that lithium aggregates promoted the efficient metalation of phenylpyridines and stabilization of phenylpyridyllithium. The BuLi-LiDMAE superbase prevented dimerization or nucleophilic addition encountered with t-BuLi or n-BuLi. The reported selective pyridine ring lithiation of 2-, 3-, and 4-phenylpyridine alpha to nitrogen opens a straightforward access to their derivatives.
Gros
Philippe
P
Synthèse Organique et Réactivité, UMR CNRS-UHP 7565, Faculté des Sciences, Université Henri Poincaré, BP 239, 54506 Vandoeuvre-Lès-Nancy, France.
Fort
Yves
Y