An inhibitor of Staphylococcus aureus exfoliative toxin.
We describe here an inhibitor of Staphylococcus aureus exfoliative toxin. The toxin was extracted from an S. aureus strain isolated from a case of staphylococcus scalded skin syndrome. The activity of the toxin was compared in tryptic soy broth and brain heart infusion broth. Both supported growth of S. aureus but the culture filtrate of brain heart infusion broth lacked exfoliative toxin activity. Furthermore it appeared to contain a substance that neutralized the action of exfoliative toxin. This suggests the possibility of a treatment for staphylococcal scalded skin syndrome and bullous impetigo.
Al-Sulami
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Department of Biology, College of Education, University of Basra, Basra, Iraq.
Al-Rubiay
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Affat
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D000818:Animals; D000992:Antitoxins / Q000494:pharmacology*; D001431:Bacteriological Techniques / Q000379:methods*; D001434:Bacteriophage Typing; D001681:Biological Assay; D002364:Caseins; D003470:Culture Media / Q000032:analysis*; D004353:Drug Evaluation, Preclinical; D005083:Exfoliatins / Q000037:antagonists & inhibitors*; D006801:Humans; D007169:Impetigo / Q000188:drug therapy* / Q000382:microbiology*; D051379:Mice; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011492:Protein Hydrolysates; D013206:Staphylococcal Scalded Skin Syndrome / Q000188:drug therapy* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000254:growth & development
D000992:Antitoxins; D002364:Caseins; D003470:Culture Media; D005083:Exfoliatins; D010713:Phosphatidylcholines; D011492:Protein Hydrolysates; C026375:trypticase-soy broth