Extracellular matrix and cardiac remodelling.
Cardiac remodelling associated with primitive and secondary cardiomyopathy is generally associated with changes in the expression in extracellular matrix (ECM) proteins as well as their transmembrane receptors, the integrins. It emerges now that the ECM provides a structural, chemical, and mechanical substrate that is essential in cardiac function and responses to pathophysiological signals. This review will describe the various elements of the ECM, its modifications that are associated with cardiac hypertrophy and heart failure, and the molecular basis bringing a better insight into the dynamics of the ECM.
Bendall
J K
JK
UR572 Inserm, IFR J Marey, hôpital Lariboisière, 41, bd de la Chapelle, 75475 Paris.
Heymes
C
C
Ratajczak
P
P
Samuel
J L
JL
D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis* / Q000494:pharmacology; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D016023:Integrins / Q000096:biosynthesis; D020257:Ventricular Remodeling / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D016023:Integrins