[Apoptosis in mouse after tetramine poisoning].
OBJECTIVE
To observe pathological changes and apoptosis in mouse brain, hart, liver and kidney after tetramine poisoning, and to provide some references for forensic identification.


METHODS
An experimental model of mouse tetramine poisoning was found, and the technology of apoptosis detection was used. The staining results were analyzed by computer image analysis competitive system.


RESULTS
(1) Quantities of apoptosis in brain, hart, liver and kidney in chronic poisoning groups are many more than in acute poisoning groups. As in same organs, Quantities of apoptosis are different after different poisoning time. In addition, the peak-time of apoptosis is not same in different organs. (2) Poison analysis showed that, all organic samples from acute poisoning groups were positive, while that from chronic poisoning groups are negative.


CONCLUSIONS
Chronic tetramine poisoning can not be detective by clinic or poison analysis while can be found changes in apoptosis, which indicate that small amount and chronic poisoning still affects the body.
Cheng
Yi-bin
YB
Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063.
Liu
Ning-guo
NG
Zhang
Jian-hua
JH
D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000473:pathology; D001952:Bridged-Ring Compounds / Q000506:poisoning*; D002452:Cell Count; D005260:Female; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D011041:Poisoning / Q000473:pathology*; D013997:Time Factors
D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine