Littoral cell angiomatosis with poorly differentiated adenocarcinoma of the lung.
We report on a 64-year-old male United States Navy Veteran of World War II, one of two identical twins, diagnosed with littoral cell angiomatosis of the spleen, liver, and lymph nodes, later found to have a massive poorly differentiated adenocarcinoma involving the mediastinum, adjoining lung, and sternum with widespread metastases. Herein we include our findings at autopsy, pertinent immunohistochemical studies, and a review of the literature pertaining to littoral cell angiomatosis with comment on its association with visceral malignancies.
Collins
Gary L
GL
Department of Pathology, University of South Florida College of Medicine, Tampa 33612, USA.
Morgan
Michael B
MB
Taylor
Frank M
FM
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary*; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D006391:Hemangioma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D013154:Spleen / Q000737:chemistry / Q000473:pathology; D013160:Splenic Neoplasms / Q000737:chemistry / Q000473:pathology*
D014408:Biomarkers, Tumor