Cholate feeding counteracts calcium-induced depression of apparent fat digestibility in rats.
This study tested the hypothesis that cholate feeding would counteract the earlier described calcium-induced inhibition of fat digestion. Rats were fed semipurified diets; either low (0.25%, w/w) or high (1.0%) in calcium, the latter diets being without or with 0.5% added sodium cholate. Apparent fat digestibility was 95.6% of intake in the rats fed the low-calcium diet. Calcium feeding significantly lowered apparent fat digestibility to 82.6%, but in the presence of cholate it was 91.2%. It is concluded that the inhibitory effect of calcium on fat digestion is mediated by diminishing the availability of bile acids.
Beynen
A C
AC
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.152, 3508 TD Utrecht, The Netherlands.
De Graaf
M J
MJ
Lemmens
A G
AG
D000818:Animals; D002136:Calcium, Dietary / Q000008:administration & dosage*; D020355:Cholates / Q000008:administration & dosage*; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism*; D004063:Digestion; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002136:Calcium, Dietary; D020355:Cholates; D004041:Dietary Fats