Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae.
Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.
Chen
Adrienne
A
Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada.
Boulton
Ian C
IC
Pongoski
Jodi
J
Cochrane
Alan
A
Gray-Owen
Scott D
SD
D015496:CD4-Positive T-Lymphocytes / Q000382:microbiology / Q000821:virology*; D006069:Gonorrhea / Q000150:complications; D015658:HIV Infections / Q000635:transmission*; D016325:HIV Long Terminal Repeat; D015497:HIV-1; D006801:Humans; D019169:Jurkat Cells / Q000382:microbiology / Q000821:virology; D009344:Neisseria gonorrhoeae / Q000502:physiology*; D014158:Transcription, Genetic