Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.
Wiltshire
Tim
T
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA. timw@gnf.org
Pletcher
Mathew T
MT
Batalov
Serge
S
Barnes
S Whitney
SW
Tarantino
Lisa M
LM
Cooke
Michael P
MP
Wu
Hua
H
Smylie
Kevin
K
Santrosyan
Andrey
A
Copeland
Neal G
NG
Jenkins
Nancy A
NA
Kalush
Francis
F
Mural
Richard J
RJ
Glynne
Richard J
RJ
Kay
Steve A
SA
Adams
Mark D
MD
Fletcher
Colin F
CF
D000818:Animals; D002874:Chromosome Mapping; D030561:Databases, Nucleic Acid; D016678:Genome; D006239:Haplotypes; D008077:Lipoproteins, LDL / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide
D008077:Lipoproteins, LDL