New insights into the diversity and function of neuronal immunoglobulin superfamily molecules.
Immunoglobulin superfamily (IgSF) proteins are implicated in diverse steps of brain development, including neuronal migration, axon pathfinding, target recognition and synapse formation, as well as in the maintenance and function of neuronal networks in the adult. We provide here a review of recent findings on the diversity and the role of transmembrane and secreted members of IgSF proteins in the nervous system. We illustrate that the complexity of IgSF protein function results from various different levels of regulation including regulation of gene expression, protein localization, and protein interactions.
Rougon
Genevieve
G
Laboratoire NMDA CNRS UMR 6156, Universite de la Mediterranee, Institut de Biologie du Developpement (IBDM), Marseille Cedex 9, 13288 France. rougon@libdm.univ-mrs.fr
Hobert
Oliver
O
D017398:Alternative Splicing; D000818:Animals; D000916:Antibody Diversity; D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D005803:Genes, Immunoglobulin; D007136:Immunoglobulins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009420:Nervous System / Q000737:chemistry / Q000276:immunology*; D019006:Neural Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D050766:Qb-SNARE Proteins; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D013045:Species Specificity; D013569:Synapses / Q000235:genetics / Q000378:metabolism
D029681:Arabidopsis Proteins; D029721:Drosophila Proteins; D007136:Immunoglobulins; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D050766:Qb-SNARE Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C103224:beat-Ia protein, Drosophila; C120751:vesicle transport v-SNARE 11 protein, Arabidopsis