Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice.
We investigated the inhibitory effect of Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus) extract on postprandial hyperlipemia in mice. A single oral administration of C. paliurus extract (250 mg/kg) suppressed an increase in plasma triacylgycerol (TG) levels when fed with 5 ml/kg of lard and olive oil. The inhibition rates were 28.6% and 24.1%, respectively, but free fatty acid (FFA) levels in plasma were not significantly affected as compared with control group mice. In addition, C. paliurus extract showed inhibitory activity toward pancreatic lipase, a key enzyme of dietary TG absorption, with an IC(50) of 9.1 microg/ml in vitro. Our results suggested that the hypolipemic action of C. paliurus extract was probably interrelated with suppression of the activity of digestive lipase, and as a result, the blood lipid level was reduced.
Kurihara
Hiroshi
H
Institute for Health Care Science, Suntory Ltd., Shimamoto-cho, Mishima-gun, Osaka, Japan. Hiroshi_Kurihara@suntory.co.jp
Asami
Sumio
S
Shibata
Hiroshi
H
Fukami
Harukazu
H
Tanaka
Takaharu
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D029525:Juglandaceae / Q000737:chemistry*; D008049:Lipase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D014280:Triglycerides; D008049:Lipase