title: Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors.
abstract: A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5, 6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.
authors.affiliation: Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100 Pavia, Italy. toma@chifis.unipv.it
authors.forename: Lucio
authors.initials: L
authors.lastname: Toma
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Giovannoni
authors.forename: Claudia
authors.initials: C
authors.lastname: Vergelli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Dal Piaz
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Young-Kook
authors.initials: YK
authors.lastname: Kim
authors.forename: Arianna
authors.initials: A
authors.lastname: Gelain
authors.forename: Daniela
authors.initials: D
authors.lastname: Barlocco
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D000097587:Sterol O-Acyltransferase 2
chemical_list: D004791:Enzyme Inhibitors; D011724:Pyridazines; D002785:Sterol O-Acyltransferase; D000097587:Sterol O-Acyltransferase 2