title: Hypertension associated with reduced plasma thrombomodulin levels and a hypercoagulable state in rats.
abstract: The plasma thrombomodulin (TM) level, an indicator of systemic endothelial cell damage, was measured in spontaneously hypertensive rats (SHR), deoxycorticosteron acetate (DOCA)-induced hypertensive rats and normotensive Wistar-Kyoto (WKY) rats to clarify its changes in hypertension. Plasma TM levels, measured by enzyme-linked immuno-sorbent assay, decreased with aging (5-20-weeks-old) in both SHR and WKY, and they were lower in SHR than age-matched WKY in all ages examined. Deoxycorticosteron acetate-induced hypertensive WKY also showed decreased TM levels compared with normotensive WKY. Accelerated coagulation and fibrinolysis shown by the increases in thrombin-antithrombin complex (TAT) and D-dimer levels were observed in both groups of hypertensive rats. These results suggest that hypertension may decrease plasma TM levels and induce a hypercoagulable state in rats.
authors.affiliation: Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., LTD., Kinashi, Yashiro-Cho, Kato-Gun, Hyogo, Japan. k-sawada@nippon-zoki.co.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Sawada
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Naiki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yago
authors.forename: Kohji
authors.initials: K
authors.lastname: Matsushita
authors.forename: Toshiho
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000209:etiology; D003900:Desoxycorticosterone / Q000494:pharmacology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006321:Heart / Q000033:anatomy & histology; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000652:urine; D008297:Male; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D018180:Thrombomodulin / Q000097:blood*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D018180:Thrombomodulin; C036309:fibrin fragment D; D003900:Desoxycorticosterone