title: Acephate induced oxidative damage in erythrocytes.
abstract: The effect of oral administration of acephate (360 mg/kg body weight), for 15 days, daily, was investigated on the erythrocytes of male rats. Activities of acetyl cholinesterase and glucose-6-phosphate dehydrogenase decreased, while those of glutathione-s-transferase and glutathione reductase increased. Decreased glutathione content and increased lipid peroxidation suggest that there was increased oxidative stress in the erythrocytes of treated animals. Increased cholesterol/phospholipid ratio in the erythrocyte membranes and morphological changes in RBCs (scanning electron microscopy studies) were observed in acephate treated animals. The results clearly suggest that acephate induced oxidative stress in erythrocytes leads to morphological changes.
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh 160014, India.
authors.forename: Aarti
authors.initials: A
authors.lastname: Thapar
authors.forename: Rajat
authors.initials: R
authors.lastname: Sandhir
authors.forename: Ravi
authors.initials: R
authors.lastname: Kiran
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D002784:Cholesterol / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D010743:Phospholipids / Q000378:metabolism; D063088:Phosphoramides; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D010743:Phospholipids; D063088:Phosphoramides; C001969:acephate; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D000110:Acetylcholinesterase; D005978:Glutathione