P. aeruginosa quorum-sensing systems and virulence.
Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.
Smith
Roger S
RS
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Iglewski
Barbara H
BH
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007378:Interleukins / Q000145:classification / Q000378:metabolism; D008954:Models, Biological; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity*; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics
D007378:Interleukins; C088386:homoserine lactone; D015107:4-Butyrolactone