Neuronal responses in the inferior colliculus of mutant mice (Bronx waltzer) with hereditary inner hair cell loss.
Bronx waltzer mice lose a great proportion of their cochlear inner hair cells during early development. Hair cell counts revealed that these mice lacked on average 86% of their inner hair cells. Outer hair cells were present in a normal number, but appeared disarranged. The effect of this inner hair cell loss on the properties of central auditory neurons was investigated by recording neuronal responses in the inferior colliculus. Neuronal thresholds were on average elevated by 40 dB compared to CBA controls. The frequency tuning curves of the mutants were broad, and in part (18.5%) multi-peaked. The tonotopy found in the inferior colliculus of the Bronx waltzer mice appeared diffuse. Both the driven and spontaneous discharge rates were not statistically significantly different from the controls. However, the average first spike latency was significantly longer in the Bronx waltzer mice.
Sterbing
S J
SJ
Department of Zoology and Neurobiology, Ruhr University, Bochum, Germany. sterbing@neuron.uchc.edu
Schrott-Fischer
A
A
D000818:Animals; D002452:Cell Count; D003051:Cochlea / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology*; D004594:Electrophysiology; D006199:Hair Cells, Auditory, Inner / Q000473:pathology* / Q000648:ultrastructure; D007245:Inferior Colliculi / Q000503:physiopathology*; D051379:Mice; D008817:Mice, Mutant Strains; D009474:Neurons / Q000502:physiology*