[Relationship of immune imbalance with the development of multiple organ failure in patients with complicated postoperative period after the cardiac surgery].
A relationship of the functional status of the viscera with the immune system was studied in 38 cardiac surgical patients with septic complications and multi-organ failure in the postoperative period. In deceased patients (n = 13), the total functional organ compensation index was lower whereas the total functional decompensation index was higher than those in survivors (n = 25). In the deceased patients, each vital organ was more commonly decompensated than that in the survivors, but a definite discrepancy was ascertained only in the immune system (92% versus 16%, p < 0.0001). The average number of decompensated organs was found to increase with the severity of immunological disorders. Therefore, there is a rather high correlation between the functional status of vital organs and the degree of immunological imbalance. The authors show it necessary to use immunity-corrective drugs (splenopid) to enhance the efficiency of treatment organ failure.
Onishchenko
N A
NA
Maremshanov
A M
AM
Suskov
O I
OI
Tsypin
A B
AB
Rebrova
O Iu
OIu
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D006348:Cardiac Surgical Procedures; D005260:Female; D006331:Heart Diseases / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D011183:Postoperative Complications; D011184:Postoperative Period
D000276:Adjuvants, Immunologic