title: Five-year angiographic outcome in patients without restenosis following coronary balloon angioplasty: a comparison between non diabetic and diabetic lesions.
abstract: Few studies have investigated the long-term angiographic outcome of successful coronary balloon angioplasty (CBA) among diabetic and nondiabetic dilated lesions. The purpose of this study was to evaluate and compare the long-term (>5 years) outcomes of diabetic and nondiabetic CBA lesions which had remained patent 3-12 months after intervention. Twenty-five patients (45 lesions) with diabetes mellitus and 79 patients (138 lesions) without diabetes mellitus were enrolled as subjects. All patients who underwent CBA without restenosis within 3-12 months of the initial CBA based on follow-up angiographic evaluation were included. Quantitative coronary angiograms performed before, immediately after CBA, during the 3-12-month period (mean 4.1 +/- 1.0 months), and at or after 5 years (mean 6.4 +/- 2.0 years) were compared. There was no significant difference in the reference diameter between nondiabetic and diabetic lesions at any of the four time points studied. The minimum lumen diameter before and immediately after the procedure and at the 3-12-month follow-up did not differ significantly between the two groups. At >5-year follow-up. the minimum lumen diameter was significantly (P = 0.005) decreased in diabetic lesions. Total occlusion occurred in 9% (4/45) of the diabetic lesions compared to only 1%, (1/138) in the nondiabetic lesions (P = 0.007). Diabetic lesions showed significant (P = 0.049) narrowing between the 3-12 month period and >5-year follow-up. Fifty-one percent (18/35) of the nondiseased vessels in the diabetic patients at the time of enrollment had new stenosis during the follow-up periods. In conclusion, compared to nondiabetic lesions, patients with diabetic lesions who underwent CBA were more predisposed to have stenotic progression and total occlusion.
authors.affiliation: Department of Medicine and Molecular Science, Division of Frontier Medical Scicnce, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan.
authors.forename: Sou
authors.initials: S
authors.lastname: Takenaka
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Nakamura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shiode
authors.forename: Kinya
authors.initials: K
authors.lastname: Shirota
authors.forename: Hiromi
authors.initials: H
authors.lastname: Suyama
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Goto
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Hirao
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Katsumi
authors.initials: K
authors.lastname: Inoue
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nagamatsu
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003327:Coronary Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging*; D003925:Diabetic Angiopathies / Q000628:therapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome