Low background, pulsatile, in vitro flow circuit for modeling coronary implant thrombosis.
We have developed an in vitro method for creating pulsatile flows to mimic coronary type flow patterns on a beat-to-beat basis. The flow is created by accelerating fluid loops about an axis, inducing relative wall motion. Using this technique, a variety of oscillating flow patterns can be generated and modulated. Such flow generation offers the potential to monitor sensitive, flow-dependent, biological parameters like thrombosis while minimizing background disturbances from pump action and circuit effects. We examined this potential by measuring the loop occlusion time for loops stented with stainless steel 7-9 NIR stents and stentless control loops.
Kolandaivelu
Kumaran
K
Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bldg 16-343, Cambridge, MA 02139, USA. kkolanda@excite.com
Edelman
Elazer R
ER
D000328:Adult; D001158:Arteries / Q000503:physiopathology / Q000601:surgery; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D003331:Coronary Vessels / Q000503:physiopathology* / Q000601:surgery; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000295:instrumentation / Q000379:methods; D005240:Feasibility Studies; D018056:Hemorheology / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D013193:Stainless Steel; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology*
D013193:Stainless Steel