title: Synthesis of (+/-)-trans- or cis-(5-aminomethyltetrahydrofuranyl)imidazole by Mitsunobu cyclization: synthetic studies toward novel histamine H3 or H4-ligands.
abstract: The (+/-)-trans- or cis-4(5)-(5-aminomethyltetrahydrofuranyl)imidazole [1 and 2] were synthesized by the Mitsunobu cyclization, starting from L-glutamic acid.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Tatatsuki, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Harusawa
authors.forename: Lisa
authors.initials: L
authors.lastname: Araki
authors.forename: Tomonari
authors.initials: T
authors.lastname: Imazu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohishi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Takushi
authors.initials: T
authors.lastname: Kurihara
mesh_terms: D003500:Cyclization; D017442:Histamine Agonists / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4; D013237:Stereoisomerism
chemical_list: C418607:HRH4 protein, human; D017442:Histamine Agonists; D007093:Imidazoles; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4