[Biological assessment of sintered titanium alloy for dental crown and bridge by means of slip casting].
OBJECTIVE
To evaluate the biological safety of sintered titanium alloy for dental crown and bridge, and provide a sound scientific basis for dental clinical practice.


METHODS
A series of tests, including acute toxicity test, cytotoxity test (agar overlay), sensitization test, oral mucous membrane irritation test, haemolysis test and micronucleus test were conducted to examine the dental crown/bridge-used titanium alloy which is processed with vacuum-sintered powder metallurgy.


RESULTS
The haemolysis rate of this material was 2.21% (less than 5%), an index of good blood compatibility. Cytotoxic effect was not observed in cell culture, nor was toxic effect observed in mouse toxicity test. Local mucous membrane irritation reaction was not found. No potential mutagenicity of this material was noted.


CONCLUSIONS
Dental crown/bridge-used titanium alloy material is of reliable was noted biological safety in dental clinical application.
Chai
F
F
Department of Prosthodontics, Affiliated Stomatologic Hospital, WCUMS, Chengdu 610041, China.
Liang
X
X
Chao
Y
Y
Liao
Y
Y
Han
X
X
D000818:Animals; D006224:Cricetinae; D003442:Crowns; D003601:Cytotoxicity Tests, Immunologic; D003722:Dental Alloys / Q000633:toxicity*; D003735:Dental Casting Technique; D003776:Dental Porcelain; D003829:Denture, Partial; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D014025:Titanium / Q000633:toxicity*
D003722:Dental Alloys; C023988:beta titanium; D003776:Dental Porcelain; D014025:Titanium