Role of itraconazole in haematology/oncology.
The antifungal agents most frequently used in prophylaxis and treatment are amphotericin B (and its new lipid forms) and azoles such as fluconazole, itraconazole, and more recently voriconazole. This review assesses the role of itraconazole in paediatric haematology/oncology practice. Its broader spectrum of activity and availability in oral and intravenous forms allow a flexible approach in the management of fungal infections.
Pandya
N A
NA
Department of Paediatric Oncology, The Royal Marsden Hospital NHS Trust, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK.
Atra
A A
AA
Riley
U
U
Pinkerton
C R
CR
D000042:Absorption; D000666:Amphotericin B / Q000009:adverse effects; D000935:Antifungal Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009181:Mycoses / Q000188:drug therapy* / Q000517:prevention & control
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B