[Study on the differentiation of K562 cell-line induced by Tanshinone II A].
OBJECTIVE
To investigate the effect of Tanshinone II A on K562 cell-line and its possible mechanism.


METHODS
Cell culture, cytomorphology and cytometrics were used.


RESULTS
The proliferative inhibition of K562 cells induced by Tanshinone II A was dose-independent, and the degrees of erythroid differentiation induced by 30 nmol/L ACM and 0.5 microgram/ml Tanshinone II A were not statistically different (P > 0.05).


CONCLUSIONS
Tanshinone II A has an inhibitive effect on the proliferation of K562 cells and an inductive effect on the differentiation of erythrocyte series. The mechanisms may be related to the changes of cell cycle and gene expressions.
Wu
Yu
Y
Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yang
Yiming
Y
Meng
Wentong
W
Li
Yun
Y
Jia
Yongqian
Y
Liu
Ting
T
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000473:pathology*; D010616:Phenanthrenes / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D016271:Proto-Oncogene Proteins c-myc; C021751:tanshinone