title: [Radiofrequency ablation of rabbit liver: correlation between dual CT findings and pathological findings].
abstract: OBJECTIVE
  To present the time-related imaging findings and correlative pathologic findings of radiofrequency pulse-irradiated regions of the liver.
  
  
  METHODS
  Radiofrequency (RF) ablation was performed in 22 rabbit livers with 15-gauge RF probes inserted percutaneously. Regions were imaged with dual-phase CT at 3 days (n = 6), 2 weeks (n = 6), 4 weeks (n = 6), and 12 weeks (n = 4) after RF ablation.
  
  
  RESULTS
  At 3 days, the regions showed a two-zone structure on plain CT and peripheral enhancement. The regions presented a three-zone structure on pathological study. Hepatocytes appeared as acidophilic bodies, and nuclei were pyknotic at the inner necrotic zone. The middle whitish zone showed enlarged sinusoids. The marginal zone was a regenerative band. At 2 weeks, the two-zone structure was obscured on unenhanced CT. The region showed a two-zone structure on pathological study. At the inner zone, acidophilic degeneration had progressed, however, cell structure remained. The marginal zone showed fibrous tissue bundles. At 12 weeks, the region was obscured on plain CT. Nuclei and cell structures had disappeared almost completely at the inner zone. Collagen fiber had replaced the marginal zone.
  
  
  CONCLUSIONS
  Zone structural CT findings reflect the pathological findings and time-related changes after RF ablation. Peripheral enhancement in the arterial phase reflects the granulation tissue layer, and its time-related decrease reflects replacement by fibrous tissue.
authors.affiliation: Department of Radiology, National Sendai Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Yuya
authors.initials: Y
authors.lastname: Rikimaru
authors.forename: Haruo
authors.initials: H
authors.lastname: Saito
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Shyoki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Miyachi
authors.forename: Syogo
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000009:adverse effects; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology; D006097:Granulation Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000473:pathology; D022781:Hepatocytes / Q000000981:diagnostic imaging / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D011817:Rabbits; D013997:Time Factors; D014057:Tomography, X-Ray Computed