title: Evaluation of fipronil spot-on in the treatment of flea allergic dermatitis in dogs.
abstract: The purpose of this study was to evaluate the effectiveness of treatment with 10 per cent fipronil solution for controlling signs of flea allergic dermatitis in dogs under field conditions. Thirty-one client-owned dogs with flea allergic dermatitis were treated with three monthly applications of 10 per cent fipronil solution. Flea counts and pruritus were significantly reduced at all post-treatment visits. At the final visit, on day 90, flea counts were reduced by 98 per cent, and pruritus was reduced or eliminated in 84 per cent of the study dogs. Dermatological lesion scores for erythema, crusts, scales and papules were also significantly improved by the final visit. The overall assessment of efficacy on day 90 was 'excellent' to 'good' for 87 per cent of the study dogs. The results demonstrate that treatment with monthly topical applications of 10 per cent fipronil solution is effective in reducing the prevalence and severity of signs of flea allergic dermatitis in dogs.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
authors.forename: L
authors.initials: L
authors.lastname: Medleau
authors.forename: T
authors.initials: T
authors.lastname: Clekis
authors.forename: T R
authors.initials: TR
authors.lastname: McArthur
authors.forename: R
authors.initials: R
authors.lastname: Alva
authors.forename: R A
authors.initials: RA
authors.lastname: Barrick
authors.forename: P
authors.initials: P
authors.lastname: Jeannin
authors.forename: J
authors.initials: J
authors.lastname: Irwin
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D005423:Siphonaptera; D012882:Skin Tests; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D011720:Pyrazoles; C082360:fipronil