Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice.
Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.
Terai
Tadamasa
T
Department of Applied Chemistry, Osaka Institute of Technology, Japan. tera@chem.oit.ac.jp
Osakabe
Kanehiro
K
Katai
Masaaki
M
Sakaguchi
Ken-Ichi
K
Narama
Isao
I
Matsuura
Tetsuro
T
Katakawa
Jun'ichi
J
Tetsumi
Tadahiro
T
D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008813:Mice, Inbred ICR; D023382:Toxicity Tests, Acute / Q000379:methods*
D004224:Diterpenes; C020750:grayanotoxin II