title: Determination of beam intensity in a single step for IMRT inverse planning.
abstract: In intensity modulated radiotherapy (IMRT), targets are treated by multiple beams at different orientations each with spatially-modulated beam intensities. This approach spreads the normal tissue dose to a greater volume and produces a higher dose conformation to the target. In general, inverse planning is used for IMRT treatment planning. The inverse planning requires iterative calculation of dose distribution in order to optimize the intensity profile for each beam and is very computation intensive. In this paper, we propose a single-step method utilizing a figure of merit (FoM) to estimate the beam intensities for IMRT treatment planning. The FoM of a ray is defined as the ratio between the delivered tumour dose and normal tissue dose and is a good index for the dose efficacy of the ray. To maximize the beam utility, it is natural to irradiate the tumour with intensity of each ray proportional to the value of the FoM. The nonuniform beam intensity profiles are then fixed and the weights of the beam are determined iteratively in order to yield a uniform tumour dose. In this study, beams are employed at equispaced angles around the patient. Each beam with its field size that just covers the tumour is divided into a fixed number of beamlets. The FoM is calculated for each beamlet and this value is assigned to be the beam intensity. Various weighting factors are incorporated in the FoM computation to accommodate different clinical considerations. Two clinical datasets are used to test the feasibility of the algorithm. The resultant dose-volume histograms of this method are presented and compared to that of conformal therapy. Preliminary results indicate that this method reduces the critical organ doses at a small expense of uniformity in tumour dose distribution. This method estimates the beam intensity in one single step and the computation time is extremely fast and can be finished in less than one minute using a regular PC.
authors.affiliation: Department of Nuclear Science, National Tsing-Hua University, Taiwan. kschuang@mx.nthu.edu.tw
authors.forename: Keh-Shih
authors.initials: KS
authors.lastname: Chuang
authors.forename: Tzong-Jer
authors.initials: TJ
authors.lastname: Chen
authors.forename: Shan-Chi
authors.initials: SC
authors.lastname: Kuo
authors.forename: Meei-Ling
authors.initials: ML
authors.lastname: Jan
authors.forename: Ing-Ming
authors.initials: IM
authors.lastname: Hwang
authors.forename: Sharon
authors.initials: S
authors.lastname: Chen
authors.forename: Ying-Chuan
authors.initials: YC
authors.lastname: Lin
authors.forename: Jay
authors.initials: J
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D008954:Models, Biological; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009928:Organ Specificity; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011786:Quality Control; D011832:Radiation Injuries / Q000517:prevention & control; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods*; D012680:Sensitivity and Specificity