[Effects of gliclazide on blood rheology of diabetes Wistar rat].
OBJECTIVE
To assess the effects of Gliclazide on blood rheology of alloxan-induced diabetes Wistar rats.


METHODS
Four weeks after the establishment of the animal models, Gliclazide was given to the rats by gastrogarage for 8 weeks. A comparison was made on the hemorrheologic parameters between the control group and the study group. Also a comparative analysis of the study group befor and after the administration of Gliclazide was performed.


RESULTS
All of the parameters related to the blood rheology of alloxan-induced diabetes Wistar rats showed significance differences in the controlled comparison and the before-and-after comparison (P < 0.05).


CONCLUSIONS
Gliclazide can obviously improve the blood rheology of diabetic Wistar rats.
Jiang
C
C
Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China.
Li
Y
Y
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D005260:Female; D005907:Gliclazide / Q000494:pharmacology*; D018056:Hemorheology / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007004:Hypoglycemic Agents; D005907:Gliclazide