Stevens-Johnson syndrome with idiopathic thrombocytopenic purpura treated with dexamethasone pulse therapy.
Stevens-Johnson syndrome (SJS) is a severe, episodic, acute, mucocutaneous hypersensitivity reaction often caused by drugs. We herewith report a case of SJS with idiopathic thrombocytopenic purpura (ITP) that did not respond to daily oral prednisolone therapy. When treated with dexamethasone pulse therapy, the response was found to be very good. Therefore, we concluded that dexamethasone pulse therapy can be a good and an effective alternative therapy for treatment of such patients. However, to establish its role, further trials in more patients are needed.
Barman
Krishna Deb
KD
Department of Dermatology and Venereology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Verma
Kaushal K
KK
Agrawal
Sudha
S
Agarwalla
Arun
A
Rijal
Arpana
A
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D007262:Infusions, Intravenous; D035002:Lower Extremity; D008297:Male; D020551:Pulse Therapy, Drug; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D012611:Scrotum; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone