title: Contrast-enhanced MR imaging with fat suppression in adult-onset septic spondylodiscitis.
abstract: Spinal infections typically involve vertebrae as well as discs, and for this reason they are called septic spondylodiscitis. Magnetic resonance imaging is the most sensitive imaging method for the evaluation of this group of spinal diseases. The use of contrast-enhanced T1-weighted sequences with fat suppression, if correctly applied, may increase information provided by MRI. Firstly, this technique allows the primary vertebral focus, which often precedes disc involvement, to be identified at a very early stage. When the disease spreads, T1-weighted fat-suppressed gadolinium dimeglumine (Gd-DTPA) enhanced images provide macroscopic details of the primary vertebral focus, disc involvement patterns, and pathways of infection diffusion. All this information, when correlated with laboratory tests, may be useful in identifying the infectious agents (tuberculous vs piogenic forms), thus enabling a suitable therapy to be started. This technique is also useful in the assessment of the real extension of the disease, providing a clear depiction of paravertebral space involvement and of psoas muscle abscesses. Dangerous complications, such as meningitis, myelitis, and epidural abscesses, may be more promptly diagnosed and fully evaluated with fat-suppressed post-contrast T1-weighted images. Finally, this imaging technique may help to differentiate infectious processes from degenerative disorders, extradural neoplastic processes, and rheumatic diseases.
authors.affiliation: Institute of Radiological Sciences, University of Messina, Piazza Immacolata di Marmo, 4, 98121 Messina, Italy. longomar@tin.it
authors.forename: M
authors.initials: M
authors.lastname: Longo
authors.forename: F
authors.initials: F
authors.lastname: Granata
authors.forename: K
authors.initials: K
authors.lastname: Ricciardi
authors.forename: M
authors.initials: M
authors.lastname: Gaeta
authors.forename: A
authors.initials: A
authors.lastname: Blandino
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001850:Bone Diseases, Infectious / Q000175:diagnosis / Q000382:microbiology; D003287:Contrast Media; D003937:Diagnosis, Differential; D015299:Discitis / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000150:complications*; D012720:Severity of Illness Index; D013166:Spondylitis / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA