title: Suppression of mammary gland tumorigenesis in diabetic rats.
abstract: The aim of this study was to compare mammary gland tumorigenesis in diabetic and non-diabetic rats. Streptozotocin and N-nitroso-N-methylurea were used to induce diabetes and mammary tumors, respectively. A suppression of mammary carcinogenesis in diabetic rats was shown by a longer latency period, a lower number of tumors per animal and a smaller final tumor volume. An 84% of the lesions developed in diabetic animals were benign tumors. Eighty day-old diabetic rats had significantly lower plasma levels of total-IGF-I and insulin versus non-diabetic rats. We postulate that the decrease in the total IGF-I and insulin levels during the promotion phase of carcinogenesis in this model plays an important role in retarding the tumor development in diabetic animals and in favoring the development of benign mammary lesions.
authors.affiliation: Radioisotopes Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Junín, Buenos Aires 956-1113, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cocca
authors.forename: Alicia
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: Mariel
authors.initials: M
authors.lastname: Núñez
authors.forename: Máximo
authors.initials: M
authors.lastname: Croci
authors.forename: Gabriela
authors.initials: G
authors.lastname: Martín
authors.forename: Graciela
authors.initials: G
authors.lastname: Cricco
authors.forename: Elena
authors.initials: E
authors.lastname: Rivera
authors.forename: Rosa
authors.initials: R
authors.lastname: Bergoc
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D016762:Genes, fos / Q000502:physiology; D007150:Immunohistochemistry; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D008770:Methylnitrosourea / Q000633:toxicity; D010179:Pancreas / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D051381:Rats; D013997:Time Factors
chemical_list: D000477:Alkylating Agents; D007328:Insulin; D018809:Proliferating Cell Nuclear Antigen; D007334:Insulin-Like Growth Factor I; D008770:Methylnitrosourea