title: Neurocognitive deficit following mitral valve surgery.
abstract: OBJECTIVE
  Neurocognitive deficit is an important complication in patients undergoing open heart surgery. The aim of this prospective, contemporary study was to objectively measure neurocognitive brain function following mechanical mitral valve replacement and mitral valve repair.
  
  
  METHODS
  Forty consecutive, unselected patients (mechanical valve replacement n=20, mean age 65+/-14; valve repair n=20, mean age 64+/-7, P=0.896) entered this prospective, contemporary study. Neurocognitive function was objectively measured by means of P300 auditory evoked potentials (peak latencies, ms) and two standard psychometric tests (Mini Mental State Examination, Trailmaking Test A (TTA)), preoperatively, 7 days and 4 months postoperatively.
  
  
  RESULTS
  Before operation, neurocognitive brain function was comparable in both patients groups (mechanical valve replacement versus valve repair: P300 potentials 374+/-25 versus 378+/-46 ms; P=0.791 and TTA 57+/-15 versus 54+/-10 s; P=0.552). Following mechanical valve replacement, neurocognitive function continuously worsened (7 day-follow-up: P300 potentials 392+/-28, P=0.001 versus preop and TTA 65+/-17, P=0.0001; 4-month follow-up: P300 potentials 406+/-39, P=0.0004; TTA 69+/-17, P=0.0001). Interestingly, neurocognitive brain function was unaffected in patients undergoing valve repair (7-day follow-up: P300 potentials 386+/-40, P=0.890 versus preop and TTA: 53+/-10, P=0.644; 4-month follow-up: P300 potentials 374+/-36, P=0.166 and TTA 54+/-11, P=0.147). At 4-month follow-up, patients with mechanical prostheses performed worse as compared to valve repair (P300 potentials: P=0.024; TTA P=0.014).
  
  
  CONCLUSIONS
  As shown by P300 auditory evoked potentials and Trailmaking Test A, there is marked neurocognitive damage related to mechanical valve replacement, whereas mitral valve repair does not affect neurocognitive function. This finding supports the beneficial effect of mitral valve repair over mechanical valve replacement in the decision-making tree of borderline cases, which are suitable for both types of procedure.
authors.affiliation: Department of Cardio-Thoracic Surgery, Vienna General Hospital, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. michael.grimm@akh-wien.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Grimm
authors.forename: Daniel
authors.initials: D
authors.lastname: Zimpfer
authors.forename: Martin
authors.initials: M
authors.lastname: Czerny
authors.forename: Juliane
authors.initials: J
authors.lastname: Kilo
authors.forename: Marie-Theres
authors.initials: MT
authors.lastname: Kasimir
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kramer
authors.forename: Anna
authors.initials: A
authors.lastname: Krokovay
authors.forename: Ernst
authors.initials: E
authors.lastname: Wolner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000209:etiology*; D003657:Decision Making; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000601:surgery; D009483:Neuropsychological Tests; D011183:Postoperative Complications; D011446:Prospective Studies; D011594:Psychometrics; D016896:Treatment Outcome