Reproductive semi-cloning respecting biparental origin. Reconstitution of gametes for assisted reproduction.
There are basically two major problems in the genesis of "cloned" gametes in mammals, which have not been addressed in the original debate article. There is no adequate discussion on the mechanisms providing for high fidelity of chromosome segregation in mitosis and meiosis, and for proper imprinting in construction of "reconstituted gametes". The original debate article is uncritical with respect to the currently insufficient database and the incomplete documentation of results.
Eichenlaub-Ritter
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Universitat Bielefeld, Fakultat Biologie, Gentechnologie/Mikrobiologie, Postfach 100131, D-33501 Bielefeld, Germany. eiri@biologie.uni-bielefeld.de
D020090:Chromosome Segregation; D019976:Cloning, Organism; D018392:Genomic Imprinting; D005854:Germ Cells; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D027724:Reproductive Techniques, Assisted