Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction.
OBJECTIVE
To evaluate the safety and effect of a home training program on muscle function in 7 patients with sporadic inclusion body myositis.


METHODS
The patients performed exercise 5 days a week over a 12-week period.


METHODS
Safety was assessed by clinical examination, repeated muscle biopsies and serum levels of creatine kinase. Muscle strength was evaluated by clinical examination, dynamic dynamometer and by a functional index in myositis.


RESULTS
Strength was not significantly improved after the exercise, however none of the patients deteriorated concerning muscle function. The histopathology was unchanged and there were no signs of increased muscle inflammation or of expression of cytokines and adhesion molecules in the muscle biopsies. Creatine kinase levels were unchanged. A significant decrease was found in the areas that were positively stained for EN-4 (a marker for endothelial cells) in the muscle biopsies after training.


CONCLUSIONS
The home exercise program was considered as not harmful to the muscles regarding muscle inflammation and function. Exercise may prevent loss of muscle strength due to disease and/or inactivity.
Arnardottir
Snjolaug
S
Department of Clinical Neuroscience Division of Neurology, Karolinska Hospital, SE-171 76 Stockholm, Sweden. snjolaug.arnardottir@ks.se
Alexanderson
Helene
H
Lundberg
Ingrid E
IE
Borg
Kristian
K
D000368:Aged; D015415:Biomarkers / Q000097:blood; D005081:Exercise Therapy / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D018979:Myositis, Inclusion Body / Q000097:blood / Q000503:physiopathology / Q000534:rehabilitation*; D010865:Pilot Projects; D012648:Self Care; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology
D015415:Biomarkers