title: Determination of benzophenones in a cosmetic matrix by supercritical fluid extraction and capillary electrophoresis.
abstract: Benzophenones are common additives in commercial sunscreen products. These UV absorbers were extracted by supercritical fluid extraction (SFE), and then analyzed by capillary zone electrophoresis (CZE) and high-performance liquid chromatography. This study was applied to identify the contents of benzophenones in cosmetic matrix, and simultaneously, to investigate the behavior of migration in CZE. Adding non-ionic surfactant (Tween 20) to optimize the separation in the CZE operation improves resolution. In SFE, we chose carbon dioxide with 2.5% modifier of 10% aqueous phosphoric acid-MeOH (1:1) as the supercritical fluid. Real recoveries of up to 92% with relative standard deviations of less than 4.0% were achieved. These analytical techniques were also applied to assay benzophenones for ten commercial sunscreen cosmetics. We found benzophenone 3 was the most commonly used sunscreen additive in Taiwan.
authors.affiliation: Department of Applied Chemistry, Providence University, 200 Chungchi Road, Shalu, Taichung, Hsien 43301, Taiwan. spwang@pu.edu.tw
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Wen-Tsong
authors.initials: WT
authors.lastname: Lee
mesh_terms: D001577:Benzophenones / Q000032:analysis*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013473:Sunscreening Agents / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D013473:Sunscreening Agents