Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation.
In the present study blood T(1) was determined as a function of hematocrit and oxygen saturation. T(1) showed a significant linear dependency on both of these parameters. In addition, oxygen dissolved in blood plasma in hyperoxygenated blood resulted in relaxation enhancement, comparable in size to that due to the change in oxygenation state of hemoglobin. As blood T(1) is a key factor for quantification of flow with arterial spin labeling methods, the influence of T(1) variation in the physiological range of hematocrit and oxygen saturation to flow determination is discussed.
Silvennoinen
M Johanna
MJ
Department of Biomedical NMR and National Bio NMR Facility, A.I. Virtanen Institute, University of Kuopio, Finland.
Kettunen
Mikko I
MI
Kauppinen
Risto A
RA
D000818:Animals; D002417:Cattle; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012039:Regional Blood Flow / Q000502:physiology; D013113:Spin Labels
D006454:Hemoglobins; D013113:Spin Labels; D010100:Oxygen