title: Are activation markers (CD25, CD38 and CD103) predictive of sensitivity to purine analogues in patients with T-cell prolymphocytic leukemia and other lymphoproliferative disorders?
abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare lymphoproliferative disorder with distinctive clinical and laboratory features. It is often resistant to conventional chemotherapy, but complete or partial responses have been documented with the use of purine analogues. We report on two cases of T-PLL with a slightly different immunophenotype but a remarkably different response to pentostatin. We discuss the possible therapeutic implications of this finding and establish a comparison between immunophenotype and sensitivity to purine analogues in patients with T-PLL and other chronic lymphoproliferative disorders.
authors.affiliation: Department of Hematology, Hospital Universitario La Paz, Planta 6a Diagonal, Paseo Castellana 261, 28046 Madrid, Spain. jdelgon@terra.es
authors.forename: Julio
authors.initials: J
authors.lastname: Delgado
authors.forename: Jesus G
authors.initials: JG
authors.lastname: Bustos
authors.forename: Ma Carmen
authors.initials: MC
authors.lastname: Jimenez
authors.forename: Evaristo
authors.initials: E
authors.lastname: Quevedo
authors.forename: Fernando
authors.initials: F
authors.lastname: Hernandez-Navarro
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000032:analysis; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD / Q000032:analysis* / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D039001:Integrin alpha Chains / Q000032:analysis; D015463:Leukemia, Prolymphocytic / Q000188:drug therapy* / Q000473:pathology; D015458:Leukemia, T-Cell / Q000188:drug therapy* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D011237:Predictive Value of Tests; D011687:Purines / Q000494:pharmacology / Q000627:therapeutic use*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012074:Remission Induction / Q000379:methods
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D039001:Integrin alpha Chains; D008562:Membrane Glycoproteins; D011687:Purines; D015375:Receptors, Interleukin-2; C091367:alpha E integrins; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1