title: Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis.
abstract: We describe the case of a 61-year-old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [(123)I]N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane and single photon emission computed tomography ([(123)I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Joong-Seok
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Si-Ryung
authors.initials: SR
authors.lastname: Han
authors.affiliation: Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Yong-An
authors.initials: YA
authors.lastname: Chung
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000628:therapy; D007552:Isotonic Solutions / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008875:Middle Aged; D017590:Myelinolysis, Central Pontine / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D009419:Nerve Tissue Proteins; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011485:Protein Binding; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D014326:Tropanes
chemical_list: D000978:Antiparkinson Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D007552:Isotonic Solutions; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D014326:Tropanes; C087210:N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane; D007980:Levodopa