title: [The prophylactic effect of BCG polysaccharides nucleic acid on the acute attack of chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To investigate the prophylactic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with chronic obstructive pulmonary disease and inquire about the mechanism thereof.
  
  
  METHODS
  Sixty patients with chronic obstructive pulmonary disease were divided into two groups. In the treatment group, 36 patients received BCG-PSN 0.5 mg intramuscular injection, quaque die alterna, for 18 times. All patients revisited the hospital every 2 weeks and were followed up for 6 months. The number and days of patients with acute attack in 3 and 6 months were assessed. In the treatment group, the blood samples were collected before treatment and 3 and 6 months after treatment for the measurement of the blood IgA, IgG, IgM, CD3, CD4 and CD8.
  
  
  RESULTS
  The number and days of patients with acute attack in the treatment group were significantly lower than those in the control group. After the treatment by BCG-PSN, blood CD4 and CD4/CD8 were significantly increased.
  
  
  CONCLUSIONS
  BCG-PSN increases the patient's cellular immunocompetence and thus serves as a good protection against the acute attack of chronic obstructive pulmonary disease.
authors.affiliation: Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Deyun
authors.initials: D
authors.lastname: Cheng
authors.forename: Bixia
authors.initials: B
authors.lastname: Zheng
authors.forename: Wenbin
authors.initials: W
authors.lastname: Chen
authors.forename: Zhuyuan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000737:chemistry*; D009696:Nucleic Acids / Q000627:therapeutic use*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000517:prevention & control* / Q000628:therapy
chemical_list: D009696:Nucleic Acids; D011135:Polysaccharides, Bacterial