[Structural-metabolic characteristics of erythrocyte membrane in patients with paranoid schizophrenia undergoing psychopharmacotherapy].
Structural features of the hydrophobic compartment and external parts of the erythrocyte membrane, Na+ and K+ ATPase activity, intensity of the free-radical oxidation of lipids, and the surface relief of erythrocytes were studied in paranoic schizophrenia patients before and after a course of pharmacotherapy. It was established that the administration of neuroleptics in therapeutic doses does not cause damage of the erythrocyte membrane.
Novitskiĭ
V V
VV
Pathologic Physiology Department, Siberian State Medical University, Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Riazantseva
N V
NV
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D005456:Fluorescent Dyes; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000097:blood* / Q000188:drug therapy; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D014150:Antipsychotic Agents; D005456:Fluorescent Dyes; C030704:magnesium sodium potassium ATPase; D000254:Sodium-Potassium-Exchanging ATPase