title: Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
abstract: We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway. In a follow-up immunochemical investigation of expression of SOCS-1 in hepatoblastomas (HBLs), the protein was markedly reduced in half of the HBL tumors we examined. CpG-rich regions upstream of the SOCS-1 gene were hypermehylated in 7 of the 15 HBL cases. The results suggest that hypermethylation may play an important role in silencing the SOCS-1 gene, not only in adult HCCs, but also in liver tumors arising in childhood.
authors.affiliation: Department of Molecular Biology and Pathology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan.
authors.forename: Hisaki
authors.initials: H
authors.lastname: Nagai
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Naka
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Terada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Komazaki
authors.forename: Aya
authors.initials: A
authors.lastname: Yabe
authors.forename: Enjing
authors.initials: E
authors.lastname: Jin
authors.forename: Oichi
authors.initials: O
authors.lastname: Kawanami
authors.forename: Tadamitsu
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Noboru
authors.initials: N
authors.lastname: Konishi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Emi
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D002648:Child; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D018197:Hepatoblastoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007223:Infant; D047908:Intracellular Signaling Peptides and Proteins; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D012097:Repressor Proteins; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins