title: Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila.
abstract: Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can affect a variety of cellular processes including apoptosis, proliferation, differentiation and motility. To investigate possible sources of bioactive lipids during development we have searched the Drosophila genome for homologs of genes involved in mammalian S1P and LPA metabolism. Here we report the developmental expression of 31 such genes by in situ hybridization to Drosophila embryos. Most show expression in specific tissues, with expression in the gut and nervous system being recurring patterns.
authors.affiliation: Skirball Institute, Developmental Genetics Program, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Renault
authors.forename: Michelle
authors.initials: M
authors.lastname: Starz-Gaiano
authors.forename: Ruth
authors.initials: R
authors.lastname: Lehmann
mesh_terms: D000446:Aldehyde-Lyases / Q000378:metabolism; D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D055572:Ceramidases; D019852:Diacylglycerol Kinase / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D017403:In Situ Hybridization; D008246:Lysophospholipids / Q000378:metabolism*; D010739:Phospholipase D / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D000099157:Sphingosine Kinase
chemical_list: D000446:Aldehyde-Lyases; D000581:Amidohydrolases; D055572:Ceramidases; D019852:Diacylglycerol Kinase; D008246:Lysophospholipids; D010739:Phospholipase D; D010741:Phospholipases A; D017853:Phosphotransferases (Alcohol Group Acceptor); D013108:Sphingomyelin Phosphodiesterase; D013110:Sphingosine; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate; C066324:ceramide kinase; C022649:sphingosine 1-phosphate lyase (aldolase)