A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids.
A facile and convenient approach to 17-ketosteroids is described. Treatment of steroids containing the C-17-dihydroxy acetone side chain with an excess of sodium methoxide in dry 1,4-dioxane under reflux, affords high yields of the corresponding 17-ketosteroids that are recovered as pure products, without the need of further purification.
Le Pera
Adolfo
A
Dipartimento di Scienze Farmaceutiche, Università degli Studi della Calabria, Via P. Bucci, Cubo 15/C, I-87036 Arcavacata di Rende (CS), Italy.
Leggio
Antonella
A
Siciliano
Carlo
C
Di Gioia
Maria L
ML
Napoli
Anna
A
Sindona
Giovanni
G
Liguori
Angelo
A
D015065:17-Hydroxycorticosteroids / Q000737:chemistry*; D015068:17-Ketosteroids / Q000138:chemical synthesis* / Q000737:chemistry; D000096:Acetone / Q000737:chemistry*; D015394:Molecular Structure
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000096:Acetone