Design and synthesis of potent N1-substituted indole melatonin receptor agonists.
The design and expeditious synthesis of two new indole analogs with up to 5-fold potency of that of melatonin is described.
Tsotinis
Andrew
A
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis-Zografou, 157 71, Athens, Greece. tsotinis@pharm.uoa.gr
Eleutheriades
Andreas
A
Hough
Katherine
K
Sugden
David
D
D000818:Animals; D015195:Drug Design; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008550:Melatonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011956:Receptors, Cell Surface / Q000819:agonists*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D044094:Receptors, Melatonin; D013329:Structure-Activity Relationship; D014982:Xenopus laevis / Q000378:metabolism
D007211:Indoles; D008024:Ligands; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D008550:Melatonin