title: Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes.
abstract: Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milan, Italy. daniele.passarella@unimi.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Passarella
authors.forename: Raffaele
authors.initials: R
authors.lastname: Favia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Giardini
authors.forename: Giordano
authors.initials: G
authors.lastname: Lesma
authors.forename: Marisa
authors.initials: M
authors.lastname: Martinelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Silvani
authors.forename: Bruno
authors.initials: B
authors.lastname: Danieli
authors.forename: Simon M N
authors.initials: SM
authors.lastname: Efange
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Mash
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011869:Radioligand Assay; D011955:Receptors, Drug / Q000187:drug effects
chemical_list: D000475:Alkenes; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D011955:Receptors, Drug; D007050:Ibogaine