title: Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats.
abstract: In the course of anthracyclin administration, melatonin acts as an effective scavenger of oxygen free radicals and exerts cardio- and nephroprotective effects. The present study aimed at corroborating cytostatic effectiveness of daunorubicin, applied in parallel with melatonin, in rats with transplanted Morris hepatoma. The percentage of tumour cells, which manifested traits of necrosis was recorded and extent of apoptosis was evaluated in tumour cells and in cells of myocardium. Daunorubicin administration was followed by a significant increase in necrosis and apoptosis in tumour cells and by intensified apoptosis in myocardium cells. Melatonin administered in parallel with daunorubicin decreased the extent of necrosis in tumour cells and reduced the proportion of apoptotic cardiomyocytes.
authors.affiliation: Department of Histology and Embryology, University School of Medicine, Wrocław. piotr@hist.am.wroc.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
authors.forename: Paweł
authors.initials: P
authors.lastname: Surowiak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Rabczyński
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D003630:Daunorubicin / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D020287:In Situ Nick-End Labeling; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008550:Melatonin / Q000494:pharmacology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D014407:Tumor Cells, Cultured / Q000637:transplantation
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D008550:Melatonin; D003630:Daunorubicin