A role for mitochondrial enzymes in inherited neoplasia and beyond.
Mitochondrial defects have been associated with neurological disorders, as well as cancers. Two ubiquitously expressed mitochondrial enzymes--succinate dehydrogenase (SDH) and fumarate hydratase (FH, fumarase)--catalyse sequential steps in the Krebs tricarboxylic-acid cycle. Inherited heterozygous mutations in the genes encoding these enzymes cause predispositions to two types of inherited neoplasia syndromes that do not share any component tumours. Homozygous mutations in the same genes result in severe neurological impairment. Understanding this link between inherited cancer syndromes and neurological disease could provide further insights into the mechanisms by which mitochondrial deficiencies lead to tumour development.
Eng
Charis
C
Clinical Cancer Genetics Program, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 420 W. 12th Avenue, Ste 690 TMRF, Columbus, Ohio 43210, USA. eng-1@medctr.osu.edu
Kiuru
Maija
M
Fernandez
Magali J
MJ
Aaltonen
Lauri A
LA
D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D002292:Carcinoma, Renal Cell / Q000201:enzymology / Q000235:genetics; D002952:Citric Acid Cycle / Q000235:genetics*; D042963:Electron Transport Complex II; D004734:Energy Metabolism; D005544:Forecasting; D005609:Free Radicals; D005649:Fumarate Hydratase / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology / Q000235:genetics; D018231:Leiomyomatosis / Q000201:enzymology / Q000235:genetics; D008928:Mitochondria / Q000201:enzymology*; D017237:Mitochondrial Encephalomyopathies / Q000201:enzymology* / Q000235:genetics; D009097:Multienzyme Complexes / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary / Q000201:enzymology* / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology; D010088:Oxidoreductases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D010235:Paraganglioma / Q000201:enzymology / Q000235:genetics; D010673:Pheochromocytoma / Q000201:enzymology / Q000235:genetics; D021122:Protein Subunits; D013385:Succinate Dehydrogenase / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D005609:Free Radicals; D009097:Multienzyme Complexes; D021122:Protein Subunits; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D005649:Fumarate Hydratase