title: Sclerosing hemangioma with lymph node metastasis.
abstract: Sclerosing hemangioma (SH) of the lung is an uncommon type of tumor, which is composed of polygonal and cuboidal cells. This disease is generally regarded as benign but extremely rare cases with lymph node metastasis have been reported. We report a case of SH with a metastasis to the regional lymph nodes. A 19-year-old girl presented with a 2-year history of coughing. A chest X-ray and a CT scan indicated a large mass in the lower lobe. As a result, a left lower lobectomy with a dissection of the hilar and interlobar lymph nodes was performed. The tumor was a well-defined huge mass with partial adhesion to the mediastinal and parietal pleura. The dissected hilar, interlobar, and intrapulmonary lymph nodes demonstrated metastasis. Histologically, the primary and metastatic tumor consisted of polygonal and cuboidal cells. Both types of tumor cells were uniformly immunoreactive to the epithelial membrane antigen (EMA) and the thyroid transcription factor-1 (TTF-1). However, the cuboidal cells tested positive for pancytokeratin, whereas the polygonal cells tested consistently negative. Postoperatively, the patient received chemotherapy and no recurrence or metastasis 2 years after surgery was noted. Although a pulmonary SH is considered to be benign, this case highlights the need for the evaluation of lymph node metastasis.
authors.affiliation: Department of Pathology, Eulji University Hospital, 24-14 Mok-dong, Jung-gu, Daejeon 301-808, Korea. phone330@emc.eulji.ac.kr
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Hae-Joung
authors.initials: HJ
authors.lastname: Sul
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kang
mesh_terms: D000328:Adult; D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008207:Lymphatic Metastasis; D012598:Sclerosis