Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease.
The paraoxonase (PON1) Gln192-->Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1*R allele frequency significantly lower than the control group (0.225 vs. 0.281, P=0.049). In the CAD patients the *R allele was more frequent than in the controls (0.230 vs. 0.213), though not significantly (P=0.28). The odds ratios (OR) adjusted for age, gender, and APOE polymorphism by logistic regression analysis highlighted that in AD the PON1 RR genotype was significantly protective (OR=0.41, 95% CI=0.19-0.90; P=0.025), whereas in CAD it appeared to be a significant risk factor (OR=5.11, 95% CI=1.09-23.9; P=0.038) limited to younger patients.
Scacchi
Renato
R
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, P.le Aldo Moro 5, 00185, Rome, Italy. renato.scacchi@uniroma1.it
Gambina
Giuseppe
G
Martini
Maria Cristina
MC
Broggio
Elisabetta
E
Vilardo
Teresio
T
Corbo
Rosa Maria
RM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D043303:Aryldialkylphosphatase; D003324:Coronary Artery Disease / Q000235:genetics*; D004950:Esterases / Q000097:blood / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic
D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human