[Cell apoptosis in closed cerebellar contusion in rat].
OBJECTIVE
To observe the cell apoptosis explore closed cerebellar contusion in rat.


METHODS
SD rats model of contusion was established and apototic cells were detected by TUNEL method at 5, 10, 30, 45, 60 min and 2, 4, 6, 8, 12 h, after injury.


RESULTS
Apototic cells in contusion area appeared at 1 h after closed cerebellar contusion, reached the peak at 4-6 h, then decreased and so as marginal area where the peak was in 6-8 h.


CONCLUSIONS
The apoptotic index of closed contusion of cerebellum in different injury time may provide a new sensitive and objective method for the forensic early injury time estimation.
Li
Xing-biao
XB
Department of Pathology, Wenzhou Medical College, Wenzhou, Zhejiang 325027.
Hu
Yun
Y
Xia
Kang
K
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology*; D002531:Cerebellum / Q000293:injuries / Q000473:pathology*; D005260:Female; D020287:In Situ Nick-End Labeling; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors