Effect of anticonvulsant dosages of potassium bromide on thyroid function and morphology in dogs.
A placebo-controlled experiment was performed to evaluate the effect of potassium bromide on the canine thyroid gland. Basal total thyroxine, free thyroxine, and basal thyrotropin serum concentrations were evaluated over a 6-month period in potassium bromide-treated and control dogs. A thyrotropin-releasing hormone stimulation test was also performed in all dogs at the beginning and conclusion of the study. Thyroid histopathology was compared between treated and control dogs at the end of the study. No difference was detected in any parameter between the two groups at the end of the study. A decline in thyroid hormone concentrations over the course of the study did occur in both groups of dogs. Potassium bromide does not appear to have a significant effect on canine thyroid function or morphology.
Paull
Lisa C
LC
Department of Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248, USA.
Scott-Moncrieff
J Catharine R
JC
DeNicola
Dennis B
DB
Glickman
Nita
N
Refsal
Kent R
KR
Glickman
Larry T
LT
D000818:Animals; D000906:Antibodies / Q000097:blood; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001965:Bromides / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D016022:Case-Control Studies; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D017680:Potassium Compounds / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012016:Reference Values; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests / Q000662:veterinary; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D000906:Antibodies; D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; D013972:Thyrotropin; D013954:Thyroglobulin; C039004:potassium bromide; D013974:Thyroxine