title: Surface-modified silica colloid for diagnostic imaging.
abstract: A method of preparing nanometer-sized oxide colloids suitable as substance carriers for size-sensitive diagnostic imaging and other biomedical applications is described. The nanometer-sized silica particles prepared by the Stober process were reacted with silane to obtain amine-terminated colloidal surfaces under aqueous conditions. The surface-modified colloids can be further treated to combine or conjugate with imaging agents and other diagnostic or therapeutic substances. The water-stable colloidal carriers are spherical and have a narrow size distribution that can be controlled to range from 10 to 200 nm.
authors.forename: Hoon
authors.initials: H
authors.lastname: Choi
authors.forename: I-Wei
authors.initials: IW
authors.lastname: Chen
mesh_terms: D003102:Colloids; D003952:Diagnostic Imaging / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D012822:Silicon Dioxide; D013499:Surface Properties; D014867:Water
chemical_list: D003102:Colloids; D004337:Drug Carriers; D014867:Water; D012822:Silicon Dioxide