title: Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
abstract: The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.
authors.affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA. timw@gnf.org
authors.forename: Tim
authors.initials: T
authors.lastname: Wiltshire
authors.forename: Mathew T
authors.initials: MT
authors.lastname: Pletcher
authors.forename: Serge
authors.initials: S
authors.lastname: Batalov
authors.forename: S Whitney
authors.initials: SW
authors.lastname: Barnes
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Tarantino
authors.forename: Michael P
authors.initials: MP
authors.lastname: Cooke
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Kevin
authors.initials: K
authors.lastname: Smylie
authors.forename: Andrey
authors.initials: A
authors.lastname: Santrosyan
authors.forename: Neal G
authors.initials: NG
authors.lastname: Copeland
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Jenkins
authors.forename: Francis
authors.initials: F
authors.lastname: Kalush
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Mural
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Glynne
authors.forename: Steve A
authors.initials: SA
authors.lastname: Kay
authors.forename: Mark D
authors.initials: MD
authors.lastname: Adams
authors.forename: Colin F
authors.initials: CF
authors.lastname: Fletcher
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D030561:Databases, Nucleic Acid; D016678:Genome; D006239:Haplotypes; D008077:Lipoproteins, LDL / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide
chemical_list: D008077:Lipoproteins, LDL