title: Identification of a novel human angiopoietin-like gene expressed mainly in heart.
abstract: The angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 ( ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Jianliang
authors.initials: J
authors.lastname: Dai
authors.forename: Kang
authors.initials: K
authors.lastname: Ying
authors.forename: Enpeng
authors.initials: E
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Yin
authors.initials: Y
authors.lastname: Ye
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Dai
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Yumin
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000595:Amino Acid Sequence; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D001483:Base Sequence; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity
chemical_list: C473567:ANGPTL5 protein, human; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D036341:Intercellular Signaling Peptides and Proteins