[The effect of novel class III anti-arrhythmia agents cardiocyclide and nibentan during activation of cardiac beta-adrenoreceptors].
The effect of cardiocyclide and nibentan--class III antiarrhythmics--on the heart rate frequencies (HRF) and the EEG intervals (PQ, QRS, QT, and QTc) was experimentally studied on narcotized rats under conditions of the isoproterenol-induced activation of beta-adrenergic structures. It was established that cardiocyclide retains properties of the class III drug, as manifested by decreased HRF and increased QT duration in the absence of changes in the conductivity. In contrast, the activity of nibentan was decreased on the background of activation of the sympathetic system.
Turilova
A I
AI
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Katsitadze
N Sh
NSh
Kaverina
N V
NV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D001549:Benzamides; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; C105049:nibentan