title: [Multivariate analysis of prognosis of patients with clinical stage I and II carcinoma of mobile tongue].
abstract: OBJECTIVE
  There are many factors affecting the prognosis of the patients with clinical stage I and II carcinoma of mobile tongue. This study was designed to analyze the most important factors affecting the prognosis.
  
  
  METHODS
  The data of long period follow-up were analyzed retrospectively for 147 patients with clinical stage I and II squamous cell carcinoma of mobile tongue to evaluate the contribution of every factors influencing on survival. Survival analysis was performed by life table method; comparison among/between groups was performed using log-rank test; multivariate analysis was carried out using Cox proportional hazard model and Logistic regression model.
  
  
  RESULTS
  Univariate analysis showed that pathological grade (G2 and G3), status of cervical lymph node, pathological stage (stage III and IV), history of alcohol consumption, primary location recurrence, regional recurrence, primary location and regional recurrence, and cancer recurrence were risk factors of the prognosis of the patients (P< 0.05). Multivariate analysis showed that locoregional recurrence (P=0.000) and pathological stage (P=0.045) could predict the prognosis. The result of Logistic regression model indicated that status of cervical lymph node (P=0.003) and history of alcohol consumption (P=0.012) were closely associated with locoregional recurrence.
  
  
  CONCLUSIONS
  Locoregional recurrence and pathological stage(stage III and IV) are the most important factors affecting the prognosis of the patients with clinical stage I and II squamous cell carcinoma of mobile tongue. The risk factors affecting locoregional recurrence of the patients are positive cervical lymph node and history of alcohol consumption.
authors.affiliation: Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Hua
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Guang-Pu
authors.initials: GP
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D014062:Tongue Neoplasms / Q000473:pathology*