title: [Mucosal localization of leishmaniasis in Tunisia: 5 cases].
abstract: BACKGROUND
  Three epidemic-clinical forms of leishmaniasis are found in Tunisia: the sporadic cutaneous form due to L. Infantumin in the North, the zoonotic cutaneous form due to L. Major in the Center and South-West, and the chronic cutaneous form due to L. Tropica in the South. We report 5 cases of mucosal leishmaniasis diagnosed in a Dermatology unit in Tunis.
  
  
  METHODS
  Four women and one man, from the North-west of Tunisia, with a mean age of 42.4 years (range: 8-75 years) presented with leishmaniasis. The lesions were localized on the mucosa of the lips in 4 patients and on the endonasal mucosa with infiltration and nasal obstruction in a 75 year-old female patient. Diagnosis of leishmaniasis was established on direct examination in 4 cases and histological examination in 3 cases and by culture in NNN milieu for one patient exhibiting a MON5 L. Major leishmaniasis. All the patients responded well to treatment with intramuscular meglumine antimoniate (Glucantime). In our 5 patients, the mucosal involvement was not as mutilating, nor resistant to treatment, as that described for the cutaneous-mucosal forms in the New World.
  
  
  CONCLUSIONS
  Mucocutaneous leishmaniasis, endemic in Central and South America, are due to L. Braziliensis. They provoke mutilating and disfiguring lesions, resistant to treatment. In Tunisia, the forms of the disease observed are dermotropic, usually responsible for cutaneous leishmaniasis. However, mucosal involvement is not uncommon and is characterized by the absence of mutilating lesions and the excellent response to treatment.
authors.affiliation: Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisie. monia.kharfi@rns.tn
authors.forename: M
authors.initials: M
authors.lastname: Kharfi
authors.forename: B
authors.initials: B
authors.lastname: Fazaa
authors.forename: E
authors.initials: E
authors.lastname: Chaker
authors.forename: M R
authors.initials: MR
authors.lastname: Kamoun
mesh_terms: D000293:Adolescent; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D014416:Tunisia