Bone marrow transplantation: it's not just about blood anymore!
Bone marrow transplantation is established as effective cell therapy for hematopoietic disorders. With the recognition that bone marrow also contains mesenchymal stem cells, with the potential to differentiate to a wide variety of mesenchymal tissues, bone marrow transplantation, in theory, may be used to treat many nonhematopoietic disorders as well. Here, we present an overview of the developments of clinically oriented marrow mesenchymal stem cell biology and it's early applications as adjunct cell therapy in conventional stem cell transplantation, and most importantly as stem cell therapy for nonhematopoietic disorders.
Horwitz
Edwin M
EM
Division of Stem Cell Transplantation and Experimental Hematology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA. Edwin.horwitz@stjude.org
D016026:Bone Marrow Transplantation; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D033581:Stem Cell Transplantation