In vitro bactericidal activities of ABT-773 against ermB strains of Streptococcus pneumoniae.
The bactericidal activities of ABT-773, a new ketolide, were compared to those of cefuroxime and amoxicillin-clavulanate against 10 strains of Streptococcus pneumoniae containing the ermB gene. MICs and time-kill curves were determined in duplicate per NCCLS guidelines with cation-adjusted Mueller-Hinton broth with 3% lysed horse blood. Viable counts were done at 0, 2, 6, and 24 h. Antibiotic concentrations tested were two and eight times the MIC. ABT-773 MICs ranged from 0.008 to 1.0 micro g/ml. Bactericidal activity was observed with ABT-773 at eight times the MIC against 4 of 10 strains at 24 h compared to 10 of 10 strains with the beta-lactam antibiotics.
Neuhauser
Melinda M
MM
Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Houston, Texas, USA.
Prause
Jennifer L
JL
Danziger
Larry H
LH
Pendland
Susan L
SL
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D003470:Culture Media; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D007700:Kinetics; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
D002511:Cephalosporins; D003470:Culture Media; D048628:Ketolides; D004917:Erythromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C405499:cethromycin; D002444:Cefuroxime