[Genetic monitoring of tuberculous infection severity in mice with complementary inheritance of resistance].
When infected with a high dose of Mycobacterium tuberculosis H37Rv intravenously, 1/St and C57BL/6 inbred mice display a similarly high degree of the severity of progressive disease characterized by short-term survival rates and a rapid body weight loss. Noteworthy, F1 hybrids between these two strains are exceptionally resistant to M. tuberculosis-triggered disease and survive about 4-fold longer than the either parental strain. The results of a segregation genetic analysis performed in this study suggest that mice of either strain carry a homozygous recessive allele at a single genetic locus which determines a high susceptibility to the disease regardless of a locus expressed in the other parental strain. Genetic complementation between these two apparently non-linked loci provides the expression of the resistant phenotype in F1 hybrids. Correspondence between these loci and the previously mapped QTLs in TB control remains to be established. There was a high correlation between the two complex phenotypes that characterize the severity of experimental tuberculosis, that is the rate of postinfection body weight loss and time to death in this experimental model.
Radaeva
T V
TV
Nikonenko
B V
BV
Apt
A S
AS
D000818:Animals; D002100:Cachexia / Q000453:epidemiology; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology*