Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk.
We conducted a hospital-based case-control study to evaluate the interactive effect of reproductive factors and glutathione S-transferase (GST) M1 and T1 genetic polymorphisms in individual susceptibility to breast cancer. The study population consisted of 189 incident breast cancer cases and 189 age-matched controls with no known malignant diseases. GSTM1/T1 genotypes were determined by a multiplex polymerase chain reaction (PCR) method, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression model. The parity factors were grouped as (1) high-risk status defined as nullipara or para with experience of first full-term pregnancy (FFTP) at or over 30 years, and (2) low-risk status defined as para with experience of FFTP under 30 years. A significant multiplicative interaction was observed between GSTM1 and GSTT1 null genotypes and high-risk status of parity factor in all women and in premenopausal women (P < or = 0.01), but not in postmenopausal women (P > 0.05). The interaction between the combined genotypes of GSTM1 and GSTT1 and status of parity factor was also significant in all women and in premenopausal women (P < 0.01). Our findings suggest that genetic polymorphisms GSTM1/T1 could modify estrogen-related breast cancer risk.
Park
Sue-Kyung
SK
Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea.
Kang
Daehee
D
Noh
Dong-Young
DY
Lee
Kyoung-Mu
KM
Kim
Sook-Un
SU
Choi
Ji-Yeob
JY
Choi
In-Mi
IM
Ahn
Se-Hyun
SH
Choe
Kuk-Jin
KJ
Hirvonen
Ari
A
Strickland
Paul T
PT
Yoo
Keun-Young
KY
D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002979:Climacteric / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D010298:Parity / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012098:Reproduction / Q000235:genetics*; D012306:Risk
D005982:Glutathione Transferase