title: Radiographic (ILO) readings predict arterial oxygen desaturation during exercise in subjects with asbestosis.
abstract: BACKGROUND
  Exercise impairment is common in subjects with asbestosis. Arterial oxygen desaturation during exercise is an important contributor to exercise limitation. The International Labour Office (ILO) classification of plain chest radiographs correlates with resting pulmonary function, but its value in predicting abnormal ventilatory responses to exercise, including desaturation, has not been explored.
  
  
  OBJECTIVE
  To determine in subjects with asbestosis (1) if radiographic profusion scores and the extent of small irregular shadows on plain chest radiographs correlate with resting lung function and abnormal ventilatory responses to exercise; and (2) if radiographic scores add value to resting lung function tests in predicting abnormal ventilatory responses to exercise.
  
  
  METHODS
  Thirty eight male subjects with asbestosis were included. Plain chest radiographs were read according to the ILO classification independently by three observers. All subjects underwent assessment of lung function and an incremental exercise test.
  
  
  RESULTS
  Profusion scores and number of affected zones correlated significantly with the percentage predicted values of single breath diffusing capacity (DLCO), forced vital capacity (FVC), and total lung capacity (TLC). Arterial oxygen desaturation occurred in 29% of the subjects. The severity of desaturation correlated significantly with profusion and the number of affected zones. The combined use of number of affected zones, FEV(1)/FVC ratio and DLCO predicted desaturation during exercise with an explained variance of 41%. VO(2)max was significantly related only to DLCO but was not predicted by the ILO score.
  
  
  CONCLUSIONS
  Arterial oxygen desaturation correlated with the profusion and extent of parenchymal abnormality on chest radiographs. The addition of morphological indices to physiological measurements is valuable for predicting oxygen desaturation during exercise but not for VO(2)max. Refinement of the radiographic scoring system and the addition of more sophisticated imaging techniques may further improve the predictive power.
authors.affiliation: Respiratory Services, Sir Charles Gairdner Hospital, Perth, Australia. ycgarylee@hotmail.com
authors.forename: Y C G
authors.initials: YC
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: S C
authors.initials: SC
authors.lastname: Pang
authors.forename: N H
authors.initials: NH
authors.lastname: de Klerk
authors.forename: D R
authors.initials: DR
authors.lastname: Hillman
authors.forename: A W
authors.initials: AW
authors.lastname: Musk
mesh_terms: D000368:Aged; D001195:Asbestosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004185:Disability Evaluation; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011859:Radiography; D012044:Regression Analysis; D012129:Respiratory Function Tests
chemical_list: D010100:Oxygen