Demyelination and cortical reorganization: functional MRI data from a case of subacute combined degeneration.
Although it is accepted that functional changes of the cortex can occur in patients with white matter diseases of the brain and might have an adaptive role in limiting the clinical consequences of subcortical injury, the pathological substrates able to elicit such cortical changes are still unknown. This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex.
Filippi
Massimo
M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy. massimo.filippi@hsr.it
Rocca
Maria A
MA
Rossi
Paolo
P
Falini
Andrea
A
Leocani
Letizia
L
Martinelli
Vittorio
V
Comi
Giancarlo
G
D002540:Cerebral Cortex / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D009473:Neuronal Plasticity / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology; D012016:Reference Values; D013003:Somatosensory Cortex / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology