title: Comparison of alpha-stat and pH-stat cardiopulmonary bypass in relation to jugular venous oxygen saturation and cerebral glucose-oxygen utilization.
abstract: Jugular venous oxygen saturation (SJVO(2)) reflects the balance between cerebral blood flow and metabolism. This study was designed to compare the effects of two different acid-base strategies on jugular venous desaturation (SJVO(2) <50%) and cerebral arteriovenous oxygen-glucose use. We performed a prospective, randomized study in 52 patients undergoing cardiopulmonary bypass (CPB) at 27 degrees C with either alpha-stat (n = 26) or pH-stat (n = 26) management. A retrograde internal jugular vein catheter was inserted, and blood samples were obtained at intervals during CPB. There were no differences in preoperative variables between the groups. SJVO(2) was significantly higher in the pH-stat group (at 30 min CPB: 86.2% +/- 6.1% versus 70.6% +/- 9.3%; P < 0.001). The differences in arteriovenous oxygen and glucose were smaller in the pH-stat group (at 30 min CPB: 1.9 +/- 0.82 mL/dL versus 3.98 +/- 1.12 mL/dL; P < 0.001; and 3.67 +/- 2.8 mL/dL versus 10.1 +/- 5.2 mL/dL; P < 0.001, respectively). All episodes of desaturation occurred during rewarming, and the difference in the incidence of desaturation between the two groups was not significant. All patients left the hospital in good condition. Compared with alpha-stat, the pH-stat strategy promotes an increase in SJVO(2) and a decrease in arteriovenous oxygen and arteriovenous glucose differences. These findings indicate an increased cerebral supply with pH-stat; however, this strategy does not eliminate jugular venous desaturation during CPB.
  
  
  CONCLUSIONS
  A prospective, randomized study in 52 patients during cardiopulmonary bypass revealed that pH-stat increased jugular venous oxygen saturation and decreased arteriovenous oxygen-glucose differences. There was no difference in the incidence of jugular venous desaturation. These findings suggest an increased cerebral blood flow with no protection against jugular venous desaturation during pH-stat.
authors.affiliation: Departments of *Cardiothoracic Surgery, †Cardiology, ‡Anesthesiology, §Preventive Medicine and Biostatistics, and ∥Assisted Circulation, Baskent University, Adana Medical Center, Adana, Turkey.
authors.forename: H Tarik
authors.initials: HT
authors.lastname: Kiziltan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Baltal
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilen
authors.forename: Gülşah
authors.initials: G
authors.lastname: Seydaoglu
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Incesoz
authors.forename: Atlay
authors.initials: A
authors.lastname: Tasdelen
authors.forename: Sait
authors.initials: S
authors.lastname: Aslamaci
mesh_terms: D000136:Acid-Base Equilibrium; D000762:Anesthesia Recovery Period; D001784:Blood Gas Analysis; D001923:Brain Chemistry / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007601:Jugular Veins / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies
chemical_list: D002245:Carbon Dioxide; D005947:Glucose; D010100:Oxygen