title: Rescue therapy with methylene blue in systemic inflammatory response syndrome after cardiac surgery.
abstract: Severe unresponsive vasoplegia syndrome following cardiopulmonary bypass is rare. The authors report a case of severe vasoplegia, unresponsive to conventional treatment three days following cardiopulmonary bypass. A single intravenous bolus (2 mg/kg) of methylene blue was administered with normalization of the peripheral resistance. The use of methylene blue as rescue therapy in severe vasoplegia syndrome is discussed.
authors.affiliation: Quebec Heart Institute/Laval Hospital, Ste-Foy. dagenaisf@hotmail.com
authors.forename: François
authors.initials: F
authors.lastname: Dagenais
authors.forename: Patrick
authors.initials: P
authors.lastname: Mathieu
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006331:Heart Diseases / Q000601:surgery; D006801:Humans; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D008751:Methylene Blue