Liposome-enabled synergistic interaction of antimicrobial agents.
Antimicrobial agents may interact synergistically when both drugs are present at the infected site for an adequate period of time at sufficient concentrations. Generally speaking, the agents in the combination show different tissue distributions and pharmacokinetics. By co-encapsulation of the drugs in a drug carrier, like liposomes, parallel tissue distributions of both drugs may be ensured and drug concentrations at the site of infection may be increased. In this presentation therapeutic efficacy of liposome-co-encapsulated gentamicin (GN) and ceftazidime (CZ) will be shown in a GN-CZ-susceptible and GN-CZ-resistant Klebsiella pneumoniae-pneumonia in rats.
Schiffelers
Raymond M
RM
Dept of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.
Storm
Gert
G
ten Kate
Marian T
MT
Stearne-Cullen
Lorna E T
LE
den Hollander
Jan G
JG
Verbrugh
Henri A
HA
Bakker-Woudenberg
Irma A J M
IA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002442:Ceftazidime / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding; D005839:Gentamicins / Q000008:administration & dosage; D007711:Klebsiella pneumoniae / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008081:Liposomes; D011092:Polyethylene Glycols; D002442:Ceftazidime