title: Cellular mechanisms of ischemia-reperfusion injury.
abstract: As of yet, only a few strategies to prevent myocardial reperfusion injury have been tested clinically. In the first minutes of reperfusion, the myocardium can be damaged by contracture development, causing mechanical stiffness, tissue necrosis, and the "stone heart" phenomenon. Reperfusion-induced contracture can have two different causes, namely, Ca2+overload-induced contracture or rigor-type contracture. Ca2+ contracture results from rapid re-energization of contractile cells with a persistent Ca2+ overload. Strategies to prevent this type of injury are directed at cytosolic Ca2+ control or myofibrillar Ca2+ sensitivity. Rigor-contracture occurs when re-energization proceeds very slowly. It does not depend on Ca2+ overload. It may be prevented by strategies improving early mitochondrial reactivation
authors.affiliation: Physiologisches Institut, Justus-Liebig-Universität, Giessen, Germany. michael.piper@physiologie.med.uni-giessen.de
authors.forename: H Michael
authors.initials: HM
authors.lastname: Piper
authors.forename: Karsten
authors.initials: K
authors.lastname: Meuter
authors.forename: Claudia
authors.initials: C
authors.lastname: Schäfer
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D003600:Cytosol / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008929:Mitochondria, Heart / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D012508:Sarcolemma / Q000502:physiology; D019831:Sodium-Calcium Exchanger / Q000502:physiology
chemical_list: D019831:Sodium-Calcium Exchanger; D000255:Adenosine Triphosphate