Renal graft failure due to type 1 primary hyperoxaluria.
Primary hyperoxaluria type 1 (PH1) usually presents with recurrent urolithiasis, nephrocalcinosis and progressive renal failure at a relatively young age. This report describes a patient who, due to the late onset of end-stage renal disease, had been diagnosed with PH1 only after failure of his second kidney graft. Retrospectively, his vascular problems, skeletal abnormalities and cardiac arrhythmias fit the picture of severe systemic oxalosis. Possible therapeutic options are discussed.
Riksen
N P
NP
Department of Nephrology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
Timmers
H J L M
HJ
Assmann
K J M
KJ
Huysmans
F Th M
FT
D003937:Diagnosis, Differential; D018450:Disease Progression; D006084:Graft Rejection / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure