title: [The effect of AG490 on NK activity and lymphocyte transformation of PBMC].
abstract: OBJECTIVE
  To examine the effect of AG490 on NK activity and lymphocyte transformation.
  
  
  METHODS
  Using MTT colorimetry to detect cell survival, NK activity and cell proliferation.
  
  
  RESULTS
  AG490 inhibited IL-2 and PHA induced peripheral blood mononuclear cell proliferation, and it inhibited NK activation.
  
  
  CONCLUSIONS
  As an inhibitor of JAK, AG490 can influence the function of normal cells.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D020014:K562 Cells / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D020032:Tyrphostins / Q000494:pharmacology*
chemical_list: D007376:Interleukin-2; D020032:Tyrphostins; C095512:alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; D011505:Protein-Tyrosine Kinases