Rhodium-catalyzed asymmetric conjugate additions of boronic acids using monodentate phosphoramidite ligands.
Monodentate phosphoramidites have been used for the first time as chiral ligands in the Rh-catalyzed enantioselective conjugate addition of arylboronic acids to enones, unsaturated esters, lactones, and nitro alkenes. High reaction rates and ee's up to 89% have been obtained.
Boiteau
Jean-Guy
JG
Stratingh Institute, Department of Organic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Imbos
Rosalinde
R
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL