title: Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
abstract: Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Reen-Yen
authors.initials: RY
authors.lastname: Kuo
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Jwu-Lai
authors.initials: JL
authors.lastname: Yeh
authors.forename: Ing-Jun
authors.initials: IJ
authors.lastname: Chen
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D018674:Adrenergic Antagonists / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003094:Collagen / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011412:Propanolamines / Q000378:metabolism / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D018674:Adrenergic Antagonists; D001593:Benzyl Compounds; D007546:Isoquinolines; D010975:Platelet Aggregation Inhibitors; D011412:Propanolamines; D011758:Pyrroles; D016718:Arachidonic Acid; D003094:Collagen; D001241:Aspirin; C033394:CGP 12177