A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides.
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.
Frederick
Michael O
MO
Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Mulder
Jason A
JA
Tracey
Michael R
MR
Hsung
Richard P
RP
Huang
Jian
J
Kurtz
Kimberly C M
KC
Shen
Lichun
L
Douglas
Christopher J
CJ