[A quantitative analysis of peptidergic innervation in sinoatrial node in cases of sudden manhood death syndrome].
OBJECTIVE
To study the distribution and proportion of neuropeptide containing nervers in the sinus node in cases of sudden manhood death syndrome (SMDS) and to explore the mechanism of SMDS.


METHODS
Immunohistochemical staining and quantitative analysis of neuropeptide Y (NPY) and vasoactive intestinal peptide(VIP) in the sinus node in 6 cases of SMDS and in 12 cases of non-cardiac death(control group) were achieved by LSAB method and computerized image system.


RESULTS
As for NPY positive materials, VIP positive materials and the ratio of VIP/NPY in the sinus nodes, there were no significant difference between the control group and SMDS group.


CONCLUSIONS
The mechanism of SMDS and the abnormality of autonomic nervous innervation in the sinoatrial nodes maybe incorrelation.
Cheng
Jian-ding
JD
Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
Chen
Yu-chuan
YC
Hu
Bing-jie
BJ
D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology; D003645:Death, Sudden / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D012849:Sinoatrial Node / Q000294:innervation*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009478:Neuropeptide Y; D014660:Vasoactive Intestinal Peptide