D-lactic acidosis secondary to short bowel syndrome.
A 12 year old boy presented with 11 episodes of weakness, ataxia, nausea, slurred speech, dehydration, and sometimes severe lethargy bordering on coma. A year previously the boy had small intestinal resections leaving 20 cm of small bowel remaining. D-lactic acidosis was diagnosed on the basis of a D-lactate level of 5.23 mmol/l. The clinical presentation of the disease is recurrent episodes of unusual neurological manifestations and severe metabolic acidosis. The diagnosis is dependent on the presentations and the plasma D-lactate level. Development of the syndrome seems to be the effect of the accumulation of D-lactic acid.
Zhang
D L
DL
Research Institute of General Surgery, School of Medicine, Nanjing University, Peoples Republic of China. phdzdl@yahoo.com
Jiang
Z W
ZW
Jiang
J
J
Cao
B
B
Li
J S
JS
D000140:Acidosis, Lactic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D002648:Child; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D012778:Short Bowel Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
D019344:Lactic Acid