Investigations into the uricolytic properties of urate oxidase in a granivorous (Columba livia domestica) and in a carnivorous (Buteo jamaicensis) avian species.
To study the uricolytic properties of urate oxidase in granivorous and carnivorous birds, experiments were conducted in pigeons (Columba livia domestica) and Red-tailed Hawks (Buteo jamaicensis). Plasma concentrations of allantoin and uric acid were determined at various times in experimental groups before and after receiving 100, 200, and 600 U/kg urate oxidase once daily and were compared with controls. All regimens caused a significant decrease in plasma uric acid concentrations within 2 days after the first administration, when compared with controls. Furthermore, both doses used in Red-tailed Hawks (200 and 100 U/kg) caused a significant postprandial suppression of plasma uric acid concentrations. Plasma allantoin concentrations were significantly higher when compared with controls. The ability of urate oxidase to prevent the physiological postprandial hyperuricaemia in Red-tailed Hawks and to reduce plasma uric acid concentrations to undetectable levels, shows the great potential of this drug for treating avian hyperuricaemia.
Poffers
J
J
Division of Avian and Exotic Animal Medicine, Department of Clinical Sciences of Companion Animals, Universiteit Utrecht, Yalelaan 8, 3584 CM Utrecht, The Netherlands.
Lumeij
J T
JT
Redig
P T
PT
D000481:Allantoin / Q000097:blood; D000818:Animals; D010856:Columbidae / Q000097:blood* / Q000378:metabolism*; D005260:Female; D008297:Male; D019518:Postprandial Period / Q000187:drug effects; D020304:Raptors / Q000097:blood* / Q000378:metabolism*; D014503:Urate Oxidase / Q000378:metabolism* / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000481:Allantoin; D014503:Urate Oxidase