New perspectives on the role of amine oxidases in physiopathology.
In the paper here presented we summarize some results obtained in our laboratory in the last few years on new structural and functional aspects of some amine oxidases (AOs), which have to be taken into consideration in defining new strategies of controlling the cellular physiopathology. In particular, the ability of Cu-AO purified from vegetal sources or from bovine serum to bind different cellular targets inducing in them conformational as well as chemical modifications are described and the consequences of this interaction on cellular functions are discussed. This is the case of the protective effect of Cu-AO against the damage induced by free radicals, cell enrichment with Cu-AO, induction of cataract and the leukocyte-endothelia interaction. The role of Cu and FAD-amine oxidases related as to the protection or damage of cells is also discussed. In this context the involvement of MAOs in the modulation of the mitochondrial functions and in the induction of apoptosis is described and some aspects of the molecular mechanism of AO inhibition by H(2)O(2) and metronidazole analyzed.
Nocera
S
S
Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, Rome, Italy.
Marcocci
L
L
Pietrangeli
P
P
Mondovì
B
B
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005609:Free Radicals; D006632:Histamine / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D009206:Myocardium / Q000473:pathology*
D004791:Enzyme Inhibitors; D005609:Free Radicals; D008795:Metronidazole; D006632:Histamine; D006861:Hydrogen Peroxide; D006631:Amine Oxidase (Copper-Containing)