title: Early hemodynamic changes after renal transplantation: determinants of low central venous pressure in the recipients and correlation with acute renal dysfunction.
abstract: BACKGROUND
  Transplantation of organs leads to several physiologic changes in the recipients who, during their anephric state on chronic hemodialysis, have increased total body water and several electrolyte imbalances. Several abnormal parameters are observed in the physiology of the renal recipient. The central venous pressure (CVP) in the recipient invariably declines despite vigorous fluid resuscitation for reasons that are not clear at the present time.
  
  
  METHODS
  We studied 77 kidney transplants retrospectively, in which we observed a significant decline in central venous pressure (CVP) in the immediate posttransplant period. This phenomenon occurred despite aggressive fluid management and positive fluid balances averaging nearly four liters. Our analysis included the time course of the phenomenon itself as well as a detailed comparison of various parameters in the recipient and the renal graft for possible correlation with this consistent decline in CVP.
  
  
  RESULTS
  Neither the absolute CVP nor the drop in CVP appeared to influence the rate of ATN. Interestingly, we found that the kinetics of the decline in CVP were remarkably similar in recipients of both cadaveric and living-related kidneys.
  
  
  CONCLUSIONS
  This finding suggests that the reperfusion injury or a related effect may be responsible for the clinical phenomenon presented in this study.
authors.affiliation: Department of Surgery, Division of Transplant Surgery, The Johns Hopkins University School of Medicine, New York, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
authors.forename: Dilip S
authors.initials: DS
authors.lastname: Kittur
authors.forename: Chumpon
authors.initials: C
authors.lastname: Wilasrusmee
authors.forename: Gaurang
authors.initials: G
authors.lastname: Shah
authors.forename: Edward
authors.initials: E
authors.lastname: Krause
authors.forename: Lloyd
authors.initials: L
authors.lastname: Ratner
mesh_terms: D000328:Adult; D002496:Central Venous Pressure; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011184:Postoperative Period; D012044:Regression Analysis; D015427:Reperfusion Injury; D012189:Retrospective Studies; D014556:Urine; D014680:Veins / Q000502:physiology; D014882:Water-Electrolyte Balance