Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages.
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.
Dunn
Kate L R
KL
Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Hospital Campus, London W2 1PG, United Kingdom.
Farrant
Jayne L
JL
Langford
Paul R
PR
Kroll
J Simon
JS
D001426:Bacterial Proteins / Q000502:physiology*; D015638:Cytochalasin D / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009345:Neisseria meningitidis / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis; D013482:Superoxide Dismutase / Q000502:physiology*
D001426:Bacterial Proteins; D015638:Cytochalasin D; D013482:Superoxide Dismutase