title: Inhibitory control following perinatal brain injury.
abstract: Evidence from developmental, lesion, and neuroimaging studies indicates that the prefrontal cortex plays a major role in executive abilities, including inhibitory control. Proficient executive performance, however, relies not only on the integrity of the prefrontal cortex but also on its interactions with other brain regions. In the current study, the authors focused on the effect that early damage to the white matter tracts interconnecting prefrontal and other brain regions has on inhibitory control. Data were collected from 13 children with bilateral spastic cerebral palsy and from a control group of 20 children with no history of neurologic compromise. Converging evidence from 3 separate paradigms is presented that strongly suggests these children experience impairments in inhibitory control. Findings are discussed within the context of current cognitive and neuroanatomical models of inhibition.
authors.affiliation: Department of Psychology, Washington University, St. Louis, Missouri 63130-4899, USA. sechrist@artsci.wustl.edu
authors.forename: Shawn E
authors.initials: SE
authors.lastname: Christ
authors.forename: Desirée A
authors.initials: DA
authors.lastname: White
authors.forename: Janice E
authors.initials: JE
authors.lastname: Brunstrom
authors.forename: Richard A
authors.initials: RA
authors.lastname: Abrams
mesh_terms: D000293:Adolescent; D001925:Brain Damage, Chronic / Q000503:physiopathology* / Q000523:psychology; D002547:Cerebral Palsy / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003342:Corpus Striatum / Q000503:physiopathology; D004193:Discrimination Learning / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020644:Midline Thalamic Nuclei / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011594:Psychometrics; D011712:Pyramidal Tracts / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012193:Reversal Learning / Q000502:physiology; D012438:Saccades / Q000502:physiology