title: Synthesis of 6'-sulfodisaccharides by beta-N-acetylhexosaminidase-catalyzed transglycosylation.
abstract: Presulfated N-acetylglucosaminyl donor (pNP beta-D-6-SO3-GlcNAc) was applied for the synthesis of sulfosugars using the beta-N-acetylhexosaminidase-catalyzed transglycosylation, to afford the critically stereocontrolled sulfodisaccharides carrying the 6-sulfo GlcNAc residue at the non-reducing sides in one step.
authors.affiliation: Laboratory of Advanced Bioelectronics, National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba 305-8565, Japan. h.uzawa@aist.go.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Uzawa
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Zeng
authors.forename: Norihiko
authors.initials: N
authors.lastname: Minoura
mesh_terms: D001230:Aspergillus / Q000201:enzymology; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013463:Sulfuric Acid Esters / Q000737:chemistry; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism*
chemical_list: D004187:Disaccharides; D013463:Sulfuric Acid Esters; D001619:beta-N-Acetylhexosaminidases