title: Perioperative infusions in paediatric patients: rationale for using Ringer-lactate solution with low dextrose concentration.
abstract: To assess the usefulness of Ringer-lactate solution with 0.9% dextrose, fluid therapy during surgery in paediatric patients was reviewed. From the literature, the need for intravenous (i.v.) infusion and water could be established. The need for sodium was also evident and use of normonatraemic i.v. solutions should be recommended to avoid hyponatraemia. Little data were found about the value of the other electrolytes. Dextrose requirements have been the subject of debate for the last two decades. The choice of dextrose concentration is a compromise between avoiding hypoglycaemia and hyperglycaemia. Four clinical trials assessing the use of Ringer-lactate solution with 0.9 or 1% dextrose in paediatric patients suggest that it is appropriate for routine infusion in paediatric patients during the perioperative period. However, fluid therapy during surgery has rarely been studied, probably because it is inexpensive, rarely leads to problems and is used in very different clinical settings. Development of consensus clinical guidelines on the use of electrolyte infusions in paediatric surgery would be helpful.
authors.affiliation: Agence générale des équipements et produits de santé, Etablissement pharmaceutique des hôpitaux de Paris, UF Affaires réglementaries, Paris, France. marie-pierre.berleur@eps.ap-hop
authors.forename: M-P
authors.initials: MP
authors.lastname: Berleur
authors.forename: A
authors.initials: A
authors.lastname: Dahan
authors.forename: I
authors.initials: I
authors.lastname: Murat
authors.forename: G
authors.initials: G
authors.lastname: Hazebroucq
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000627:therapeutic use; D005440:Fluid Therapy / Q000379:methods*; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D019990:Perioperative Care; D000077325:Ringer's Lactate; D013514:Surgical Procedures, Operative; D014867:Water
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D014867:Water; D005947:Glucose