title: Florence Sabin and the mechanism of blood vessel lumenization during vasculogenesis.
abstract: The notion that blood vessel lumina and primordial blood plasma are linked by a single mechanism, intracellular vacuolation of angioblasts, has, for the most part, been overlooked since it was first described in the early decades of the last century. That vacuolation may play a major role in blood vessel formation during vasculogenesis is revisited from the perspective of Florence Sabin's seminal studies in the nascent mesoderm of living chick blastoderms.
authors.affiliation: Department of Anatomy, University of Wisconsin-Madison Medical School, Madison, WI 53706, USA. kdowns@facstaff.wisc.edu
authors.forename: Karen M
authors.initials: KM
authors.lastname: Downs
mesh_terms: D000818:Animals; D001756:Blastoderm / Q000502:physiology / Q000648:ultrastructure; D002642:Chick Embryo; D004626:Embryology / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D008648:Mesoderm / Q000502:physiology / Q000648:ultrastructure; D009024:Morphogenesis; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014481:United States; D014617:Vacuoles / Q000502:physiology / Q000648:ultrastructure; D015017:Yolk Sac / Q000502:physiology / Q000648:ultrastructure