[Maxacalcitol, a medicine for secondary hyperparathyroidism (2 degrees HPT)].
Maxacalcitol (Oxarol) is a derivative of vitamin D compounds applied for the secondary hyperparathyroidism (2 degrees HPT) of hemodialysis (HD) patients as an injection and psoriasis as an ointment. 2 degrees HPT is one of the complications in HD patients with hyperplasia of parathyroid glands and elevated serum parathyroid hormone (PTH) levels. On the other hand, vitamin D compounds are known to have multiple actions in many organs (promotion of calcium absorption from the small intestine, induction of differentiation of leukemia cells, differentiation and proliferation of the chondrocyte, muscle cells and epidermal cells, immunosuppressive activities) and their activities on parathyroid glands seem to be mediated by the vitamin D receptor (genomic action). It was reported that both serum PTH and PTH mRNA levels were suppressed by Maxacalcitol with less calcemic action and also Maxacalcitol could ameliorate high-turnover bone and marked osteitis fibrosa in uremic rats. Here I review many reports focused on the effects of Maxacalcitol on the 2 degrees HPT.
Imazeki
Ikuo
I
Product Research Lab., Chugai Pharmaceutical Co., Ltd., 41-8, Takada 3-chome, Toshima-ku, Tokyo 171-8545, Japan. imazekiiko@chugai-pharm.co.jp
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002117:Calcitriol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy; D017326:Clinical Trials, Phase III as Topic; D004304:Dosage Forms; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy* / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D011565:Psoriasis / Q000188:drug therapy; D051381:Rats; D018167:Receptors, Calcitriol / Q000502:physiology
D004304:Dosage Forms; D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; D002117:Calcitriol; C051883:maxacalcitol