Relationship between anti-oxidant activities and doxorubicin-induced lipid peroxidation in P388 tumour cells and heart and liver in mice.
1. The present study found that, compared with mouse heart and liver, P388 ascitic tumour had significantly lower superoxide dismutase (SOD) activity and that compared with the mouse liver, the heart had significantly lower SOD and catalase activities, as well as a lower glutathione content. 2. At 7.5 mg/kg, doxorubicin (DOX), a superoxide radical inducer, induced significant lipid peroxidation only in the tumour, whereas 15.0 mg/kg DOX induced lipid peroxidation in both the tumour and heart, but not in the liver. 3. Overall, the results of the present study suggest that the differential anti-oxidant activities in P388 ascitic tumour, heart and liver in mice may explain their differential responses and, hence, susceptibility to DOX-induced lipid peroxidation.
Liu
Qi-Yuan
QY
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore.
Tan
Benny K H
BK
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D007941:Leukemia P388 / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009206:Myocardium / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D000975:Antioxidants; D004317:Doxorubicin