Alternative solvents for elevated-temperature solid-phase parallel synthesis. Application to thionation of amides.
A new class of higher-boiling solvents was investigated for elevated-temperature solid-phase parallel synthesis. Extremely low vapor pressures at high temperature and a broader range of solvent effect tuning make this new class of solvents an ideal choice for high-temperature parallel solid-phase synthesis. Benzyl benzoate is identified as a superior high-boiling solvent for parallel solid-phase Lawesson's thionation reactions.
Coats
Steven J
SJ
Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776, USA. scoats@prdus.jnj.com
Link
Jeffrey S
JS
Hlasta
Dennis J
DJ