Binding of an inhibitor of the p53/MDM2 interaction to MDM2.
The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.
Duncan
Sara J
SJ
Dept of Chemistry, Lensfield Rd, Cambridge, UK CB2 1EW.
Cooper
Matthew A
MA
Williams
Dudley H
DH
D005285:Fermentation; D005670:Fusarium / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009687:Nuclear Proteins; D010456:Peptides, Cyclic / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2; D020349:Surface Plasmon Resonance; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D009687:Nuclear Proteins; D010456:Peptides, Cyclic; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C434864:chlorofusin; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2