Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp.
Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.
Feng
Yunjiang
Y
Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Blunt
John W
JW
Cole
Anthony L J
AL
Cannon
John F
JF
Robinson
Ward T
WT
Munro
Murray H G
MH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D004578:Electron Spin Resonance Spectroscopy; D007941:Leukemia P388; D051379:Mice; D003904:Mitosporic Fungi / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C476090:T987 A compound; C476091:T987 B compound