title: Paracingulate sulcus morphology in men with early-onset schizophrenia.
abstract: BACKGROUND
  Cingulate dysfunction has been reported in schizophrenia. Although the paracingulate sulcus (PCS) is known to be asymmetric in healthy people, little information is available about its morphology in schizophrenia.
  
  
  OBJECTIVE
  To search for morphological anomalies of the PCS in men with early-onset schizophrenia.
  
  
  METHODS
  The PCS was examined in magnetic resonance images of the brains of men with schizophrenia and 100 healthy men.
  
  
  RESULTS
  A significant asymmetry was found in the brains of healthy volunteers, whose sulci were more frequent and more marked in the left hemisphere. In contrast, the sulcus was as frequent in the right as in the left hemisphere in the patient group. Moreover, patients displayed significantly more rightward asymmetry, and overall less-asymmetrical patterns than the comparison group.
  
  
  CONCLUSIONS
  Since the PCS has developed at 36 weeks of gestation, these findings suggest an impaired maturation of the cingulate region during the third trimester.
authors.affiliation: NSERM - CEA, Frédéric Joliot Hospital Department, Orsay, France.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Le Provost
authors.forename: David
authors.initials: D
authors.lastname: Bartres-Faz
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Paillere-Martinot
authors.forename: Eric
authors.initials: E
authors.lastname: Artiges
authors.forename: Sabina
authors.initials: S
authors.lastname: Pappata
authors.forename: Christophe
authors.initials: C
authors.lastname: Recasens
authors.forename: Mercedes
authors.initials: M
authors.lastname: Perez-Gomez
authors.forename: Miquel
authors.initials: M
authors.lastname: Bernardo
authors.forename: Imma
authors.initials: I
authors.lastname: Baeza
authors.forename: Frank
authors.initials: F
authors.lastname: Bayle
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005314:Embryonic and Fetal Development; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000196:embryology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012559:Schizophrenia / Q000473:pathology*