Propofol 1% versus propofol 2% in children undergoing minor ENT surgery.
BACKGROUND
The induction characteristics of propofol 1% and 2% were compared in children undergoing ENT surgery, in a prospective, randomized, double-blind study.


METHODS
One hundred and eight children received propofol 1% (n=55) or 2% (n=53) for induction and maintenance of anaesthesia. For induction, propofol 4 mg kg(-1) was injected at a constant rate (1200 ml h(-1)), supplemented with alfentanil. Intubating conditions without the use of a neuromuscular blocking agent were scored.


RESULTS
Pain on injection occurred in 9% and 21% of patients after propofol 1% and 2%, respectively (P=0.09). Loss of consciousness was more rapid with propofol 2% compared with propofol 1% (47 s vs 54 s; P=0.02). Spontaneous movements during induction occurred in 22% and 34% (P=0.18), and intubating conditions were satisfactory in 87% and 96% (P=0.19) of children receiving propofol 1% or 2%, respectively. There were no differences between the two groups in respect of haemodynamic changes or adverse events.


CONCLUSIONS
For the end-points tested, propofol 1% and propofol 2% are similar for induction of anaesthesia in children undergoing minor ENT surgery.
Pellégrini
M
M
Division of Anaesthesiology, Department of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland. michel.pellegrini@hcuge.ch
Lysakowski
C
C
Dumont
L
L
Borgeat
A
A
Tassonyi
E
E
D000233:Adenoidectomy / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D006801:Humans; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D010146:Pain / Q000209:etiology; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D013997:Time Factors; D014068:Tonsillectomy / Q000379:methods
D018686:Anesthetics, Intravenous; D015742:Propofol