title: [Use of nitric oxide in a newborn child with pulmonary cystic adenomatoid malformation].
abstract: Nitric oxide (NO) inhalation therapy relaxes preconstricted pulmonary blood vessels without causing concomitant systemic hypotension and increases oxygen uptake into the blood. NO inhalation is a new treatment for various disorders of neonates (respiratory distress syndrome, persistent pulmonary hypertension, congenital heart disease and congenital diaphragmatic hernia). There is no references of its use in congenital cystic adenomatoid malformation (CCAM). We report a case of a newborn of 33 week's gestation. The infant underwent resection of the CCAM that had occupied the right middle lobe. At the end of the operation, arterial blood gases at a fractional inspired oxygen concentration (FiO2) of 1.0 reveled acidosis and severe hypoxemia probably due to persistent pulmonary hypertension. NO therapy was used for 16 hours with decreased oxygen need and increase of arterial blood oxygen data. According to the extent of the adenomatoid lesion, likely due to the compression of the surrounding tissue, these patients at times postoperatively develop difficulty in oxygenation and ventilation and the changes are similar to those patients with congenital diaphragmatic hernia. The use of NO in these disorders are successfull.
authors.affiliation: Servicio de Pediatría, Hospital Aránzazu, Donostia, San Sebastián.
authors.forename: P
authors.initials: P
authors.lastname: Gorrotxategi Gorrotxategi
authors.forename: I
authors.initials: I
authors.lastname: Eizaguirre Sexmilo
authors.forename: A
authors.initials: A
authors.lastname: Iturrioz Mata
authors.forename: G
authors.initials: G
authors.lastname: Miranda Abejón
authors.forename: V
authors.initials: V
authors.lastname: Collado Espina
authors.forename: B
authors.initials: B
authors.lastname: Birritxinaga Gaztelurrutia
mesh_terms: D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use*
chemical_list: D009569:Nitric Oxide