Effect of thyroxine on some digestive enzymes of the adult male toad, Bufo melanostictus.
Thyroxine is known to play an important role during the developmental process of amphibians. The present work is designed on the hypothesis that a functional relationship exists between the thyroid gland and digestive physiology in the adult toad. Three doses of thyroxine (25 microg/100 g; 50 microg/100 g; 100 microg/100 microg body weight) were orally administered daily to the adult male toad, Bufo melanostictus and changes in -amylase, pepsin, trypsin, and esterase activities of the different zones of the digestive tract, pancreas and liver were observed. The observations were made on 7, 15, and 30 days of thyroxine treatment. The result shows that the dose of 25 microg increases the enzyme activities in the gastrointestinal tract, liver and pancreas of 7 days treatment. However, prolonged treatment with all the doses shows little effect on these enzymes. The pattern of changes in the enzymatic activities in the digestive tract of the adult male toads show more advanced compartmentalization than that of fishes. It is also found that site-specific enzyme production is not pronounced in this amphibious vertebrate. It is proposed that a positive functional relationship between thyroxine and digestive enzymes exists in the adult male toad.
Bhattacharyya
Sanat K
SK
Department of Physiology, The Calcutta Homoeopathic Medical College, 265-266 A. P. C. Road, Kolkata 700 009, India.
Chaki
Korak K
KK
Misra
Kamales K
KK
D000818:Animals; D002025:Bufonidae; D004064:Digestive System / Q000187:drug effects* / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D004950:Esterases / Q000378:metabolism; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism; D000516:alpha-Amylases / Q000378:metabolism
D004950:Esterases; D000516:alpha-Amylases; D014357:Trypsin; D010434:Pepsin A; D013974:Thyroxine