title: Comorbidity of schizophrenia and galactosemia: effective clozapine treatment with weight gain.
abstract: Weight gain with atypical antipsychotics such as clozapine has been hypothesized to have a multifactorial genesis. Beside changes in neurotransmitter systems caused by antipsychotic-induced receptor blockade, hormonal changes and other neuroleptic side-effects (sedation, reduced activity, reduced basal metabolic rate, dry mouth) are also discussed. Our unique case report of a patient with comorbid galactosemia and schizophrenia is an interesting example of weight gain being a positive side-effect of clozapine, not necessarily associated with increased appetite and higher caloric intake.
authors.affiliation: Department of Psychiary and Psychotherapy, University-Hospital Eppendorf, Hamburg, Germany. haasen@uke.uni-hamburg.de
authors.forename: Christian
authors.initials: C
authors.lastname: Haasen
authors.forename: Martin
authors.initials: M
authors.lastname: Lambert
authors.forename: Oktay
authors.initials: O
authors.lastname: Yagdiran
authors.forename: Anne
authors.initials: A
authors.lastname: Karow
authors.forename: Michael
authors.initials: M
authors.lastname: Krausz
authors.forename: Dieter
authors.initials: D
authors.lastname: Naber
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D005693:Galactosemias / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine