[Neuromuscular complications after allogeneic bone marrow transplantation].
Neuromuscular syndromes following allogeneic bone marrow transplantation (BMT), although occasionally described,were not the focus of studies concerning neurologic complications following bone marrow transplantation. In this study,we summarize different polyneuropathy syndromes following BMT and report on patients with myasthenia gravis and inflammatory neuromuscular disorders such as myositis or fasciitis. Concerning the etiology of neuropathies, a neurotoxicity of immunosuppressants,a preexisting disorder due to the underlying disease as well as an association with graft-versus-host disease (GVHD) is discussed.GVHD-associated polyneuropathies as well as muscular complications have been found to occur during the early BMT phase, while myasthenia gravis is a late neurologic complication of GVHD.
Padovan
C S
CS
Neurologische Klinik, Ludwig-Maximilians-Universität München, Munich. padovan@nefo.med.uni-muenchen.de
Sostak
P
P
Reich
P
P
Kolb
H-J
HJ
Müller-Felber
W
W
Straube
A
A
D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D009460:Neurologic Examination; D009468:Neuromuscular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D017285:Polymyositis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D011115:Polyneuropathies / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors