title: Description of an epidemic simulation model for use in evaluating strategies to control an outbreak of foot-and-mouth disease.
abstract: OBJECTIVE
  To develop a spatial epidemic model to simulate intraherd and interherd transmission of foot-and-mouth disease (FMD) virus.
  
  
  METHODS
  2,238 herds, representing beef, dairy, swine, goats, and sheep, and 5 sale yards located in Fresno, Kings, and Tulare counties of California.
  
  
  METHODS
  Using Monte-Carlo simulations, a spatial stochastic epidemic simulation model was developed to identify new herds that would acquire FMD following random selection of an index herd and to assess progression of an epidemic after implementation of mandatory control strategies.
  
  
  RESULTS
  The model included species-specific transition periods for FMD infection, locations of herds, rates of direct and indirect contacts among herds, and probability distributions derived from expert opinions on probabilities of transmission by direct and indirect contact, as well as reduction in contact following implementation of restrictions on movements in designated infected areas and surveillance zones. Models of supplemental control programs included slaughter of all animals within a specified distance of infected herds, slaughter of only high-risk animals identified by use of a model simulation, and vaccination of all animals within a 5- to 50-km radius of infected herds.
  
  
  CONCLUSIONS
  The FMD model represents a tool for use in planning biosecurity and emergency-response programs and in comparing potential benefits of various strategies for control and eradication of FMD appropriate for specific populations.
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Bates
authors.forename: Mark C
authors.initials: MC
authors.lastname: Thurmond
authors.forename: Tim E
authors.initials: TE
authors.lastname: Carpenter
mesh_terms: D000818:Animals; D002140:California / Q000453:epidemiology; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D003140:Communicable Disease Control; D003198:Computer Simulation; D004196:Disease Outbreaks / Q000517:prevention & control* / Q000662:veterinary*; D005536:Foot-and-Mouth Disease / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology; D015511:Goat Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D006041:Goats; D009010:Monte Carlo Method; D012757:Sheep Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D013045:Species Specificity; D013269:Stochastic Processes; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D014765:Viral Vaccines