Prognostic factors for chronic active Epstein-Barr virus infection.
Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-morbidity disease. To clarify the prognostic factors, a national survey was performed in Japan, and data for 82 patients who met the criteria for CAEBV were analyzed. Of these 82 patients, 47 were alive and 35 had already died. Multivariate analysis revealed that thromobocytopenia and age at disease onset were correlated with mortality. The probability of 5-year survival was 0.45 for older patients (onset age, > or = 8 years), 0.94 for younger patients (P<.001), 0.38 for patients with thrombocytopenia (platelet count < 12 x 10(4) platelets/microL at diagnosis), and 0.76 for patients without thrombocytopenia (P=.01). Furthermore, patients with T cell infection by EBV had shorter survival times than patients with natural killer cell infection (probability of 5-year survival, 0.59 vs. 0.87; P<.009). Patients with CAEBV with late onset of disease, thrombocytopenia, and T cell infection had significantly poorer outcomes.
Kimura
Hiroshi
H
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkimura@med.nagoya-u.ac.jp
Morishima
Tsuneo
T
Kanegane
Hirokazu
H
Ohga
Shouichi
S
Hoshino
Yo
Y
Maeda
Akihiko
A
Imai
Shosuke
S
Okano
Motohiko
M
Morio
Tomohiro
T
Yokota
Shumpei
S
Tsuchiya
Shigeru
S
Yachie
Akihiro
A
Imashuku
Shinsaku
S
Kawa
Keisei
K
Wakiguchi
Hiroshi
H
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006306:Health Surveys; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D013601:T-Lymphocytes / Q000821:virology; D013921:Thrombocytopenia / Q000175:diagnosis