title: The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug.
abstract: The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
authors.affiliation: Department of Chemistry, University of Western Australia, Crawley, WA 6009, Australia.
authors.forename: Murray S
authors.initials: MS
authors.lastname: Davies
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Berners-Price
authors.forename: John W
authors.initials: JW
authors.lastname: Cox
authors.forename: Nicholas
authors.initials: N
authors.lastname: Farrell
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004247:DNA / Q000737:chemistry*; D018736:DNA Adducts / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013698:Templates, Genetic
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D018736:DNA Adducts; D004277:DNA, Single-Stranded; D009944:Organoplatinum Compounds; D004247:DNA