title: Mild cognitive impairment: experience from a memory clinic.
abstract: Mild cognitive impairment (MCI) is sometimes a transition between normal aging and dementia. We investigated the occurrence of MCI in a population referred to a memory clinic. The criteria used to diagnose the state were similar to those used by Petersen et al. in many previous publications. A clinical evaluation after approximately 3 years was also performed. In a subsample of 43 subjects, we found that, during 1 year, 37% (136/402) of all investigated subjects were patients with MCI. After a mean follow-up time of 3 years, 11% (5/43) showed cognitive improvement, while 53% (23/43) were stable and showed no cognitive decline or improvement. Fifteen out of 42 patients (35%) deteriorated and were diagnosed as demented during the same time. We conclude that MCI is a heterogeneous concept and that the outcome at follow-up is dependent on which population is studied and how MCI has been defined.
authors.affiliation: Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. lars-Olaf.Wahlund@neurotec.ki.se
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Eva
authors.initials: E
authors.lastname: Pihlstrand
authors.forename: Maria Eriksdotter
authors.initials: ME
authors.lastname: Jönhagen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology; D018450:Disease Progression; D005500:Follow-Up Studies; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012075:Remission, Spontaneous; D013548:Sweden / Q000453:epidemiology