title: Prognostic value of predischarge dobutamine stress echocardiography in chest pain patients with a negative cardiac troponin T.
abstract: OBJECTIVE
  We prospectively studied the prognostic value of predischarge dobutamine stress echocardiography (DSE) in low-risk chest pain patients with a normal or nondiagnostic electrocardiogram (ECG) and a negative serial troponin T.
  
  
  BACKGROUND
  Noninvasive stress testing is recommended before discharge or within 72 h in patients with low-risk chest pain. The prognostic value of immediate DSE has not been studied in a blinded, prospective fashion.
  
  
  METHODS
  Patients presenting at the emergency room within 6 h of symptom onset and a normal or nondiagnostic ECG were eligible. Dobutamine stress echocardiography was performed after unstable coronary artery disease was ruled out by a standard rule-out protocol and a negative serial troponin T; the occurrence of any new wall motion abnormality was considered positive. Results were kept blinded. End points were cardiac death, myocardial infarction, rehospitalization for unstable angina or revascularization.
  
  
  RESULTS
  In total, 377 patients were included. There were 2 deaths, 2 myocardial infarctions, 8 rehospitalization for unstable angina, and 10 revascularizations at six-month follow-up. The end points occurred in 8/26 (30.8%) patients with a positive versus 14/351 (4.0%) patients with a negative DSE (odds ratio, 10.7; 95% confidence interval, 4.0 to 28.8; p < 0.0001). By multivariate analysis, DSE remained a predictor of end points (p < 0.0001).
  
  
  CONCLUSIONS
  A predischarge DSE had important, independent prognostic value in low-risk, troponin negative, chest pain patients.
authors.affiliation: Department of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
authors.forename: Radha
authors.initials: R
authors.lastname: Bholasingh
authors.forename: Jan Hein
authors.initials: JH
authors.lastname: Cornel
authors.forename: Otto
authors.initials: O
authors.lastname: Kamp
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Straalen
authors.forename: Gerard T
authors.initials: GT
authors.lastname: Sanders
authors.forename: Jan G P
authors.initials: JG
authors.lastname: Tijssen
authors.forename: Victor A W M
authors.initials: VA
authors.lastname: Umans
authors.forename: Cees A
authors.initials: CA
authors.lastname: Visser
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Winter
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015331:Cohort Studies; D004311:Double-Blind Method; D025401:Echocardiography, Stress; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T