title: The next generation of liposome delivery systems: recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients.
abstract: Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-beta1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.
authors.affiliation: ALZA Corp, Mountain View, California 94025, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Abra
authors.forename: R B
authors.initials: RB
authors.lastname: Bankert
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.forename: N K
authors.initials: NK
authors.lastname: Egilmez
authors.forename: K
authors.initials: K
authors.lastname: Huang
authors.forename: R
authors.initials: R
authors.lastname: Saville
authors.forename: J L
authors.initials: JL
authors.lastname: Slater
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: S J
authors.initials: SJ
authors.lastname: Yokota
mesh_terms: D000645:Ammonium Sulfate / Q000494:pharmacology; D000925:Anticoagulants / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003911:Dextrans / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D008024:Ligands; D008051:Lipid Bilayers / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D003911:Dextrans; D008024:Ligands; D008051:Lipid Bilayers; D008081:Liposomes; D004317:Doxorubicin; D002945:Cisplatin; D000645:Ammonium Sulfate; D002166:Camptothecin