[Correction with zaditen of impaired activity of pancreatic digestive enzymes in sensitization and anaphylactic shock].
The effect of the antihistaminic drug zaditen on the activity of pancreatic digestive enzymes was studied in white rats under sensitization and anaphylactic shock conditions. The sensitization and anaphylaxis are accompanied by significant changes in the spectrum and activity of pancreatic enzymes (alpha amylase, protease complex, lipase), leading to disorders in the digestion and assimilation of proteins, fats, and carbohydrates. Zaditen reduced negative changes in the enzyme secretion system of pancreas under conditions of this pathology.
Ismailov
S R
SR
Department of Pharmacology and Clinical Pharmacology, First State Medical Institute, ul. Al-Kharezmi 25, Urgench, 740000 Uzbekistan.
D000707:Anaphylaxis / Q000201:enzymology* / Q000517:prevention & control; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006868:Hydrolysis; D007114:Immunization / Q000009:adverse effects; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D051381:Rats; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D006634:Histamine H1 Antagonists; D000516:alpha-Amylases; D007665:Ketotifen