title: Crossed aphasia with left spatial neglect and visual imperception: a case report.
abstract: A 64-year-old right-handed woman with no left-handers in the family developed aphasia associated with moderate left hemiparesis and dense left homonymous hemianopia following rupture of a right middle cerebral artery aneurysm and subsequent selective surgery confined to the right hemisphere. Severe left spatial neglect and constructional apraxia were also present. The patient was an achondroplasic dwarf whose previous medical and neurological history was otherwise unremarkable. Computed tomography of the brain showed a large right temporo-insulofrontoparietal lesion. Language and nonverbal cognitive functions were assessed after 2 and 6 months, and then four years later. A reportedly overall language disruption in the acute period evolved into Wernicke's aphasia and then into a mild form of conduction aphasia. The associated left spatial neglect eventually shrank to a minimum. The patient never had clinically detectable visual agnosia, but on specific tests of visual recognition and perception some impairment was found four years after onset. The left hemiparesis disappeared in time while the left hemianopia persisted. This case is a convincing example of an entirely righthanded person in whom both linguistic and visuospatial functions are represented in the right hemisphere.
authors.affiliation: Neurological Clinic, University of Brescia, Spedali Civili, I-25125 Brescia, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Paghera
authors.forename: P
authors.initials: P
authors.lastname: Mariën
authors.forename: L A
authors.initials: LA
authors.lastname: Vignolo
mesh_terms: D000130:Achondroplasia / Q000150:complications; D000381:Agraphia / Q000209:etiology / Q000503:physiopathology; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000150:complications / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D011597:Psychomotor Performance; D013028:Space Perception; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000503:physiopathology