Extent of resection and outcome after curative resection for intrahepatic cholangiocarcinoma.
According to the classification from the Liver Cancer Study Group of Japan, ICC can be classified into three major macroscopic types: MFCC, periductal-infiltrating, and intraductal-growth [19]. Although most ICC cases in the literature seem to be cases of MFCC, they are actually mixtures of MFCC and non-MFCC. Subtypes of ICC should be specified in future studies. Radiologic findings of MFCC are similar to those of secondary liver cancer, and the preoperative diagnosis of MFCC is sometimes difficult. The outcome after surgical treatment for MFCC is slightly worse than that for HCC. Among patients with MFCC, almost all recurrences occur within a year, and most patients with recurrence die within 2 years after hepatic resection. Lymph node metastasis is the most distinctive prognostic factor, and the presence of lymph node metastasis in MFCC may be a sign of disseminated disease.
Kokudo
Norihiro
N
Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-8655.
Makuuchi
Masatoshi
M
D000818:Animals; D001650:Bile Duct Neoplasms / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D017024:Chemotherapy, Adjuvant; D018281:Cholangiocarcinoma / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome