The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
The open field is a very popular animal model of anxiety-like behavior. An overview of the literature on the action elicited by effective or putative anxiolytics in animal subjected to this procedure indicates that classical treatments such as benzodiazepine receptor full agonists or 5-HT(1A) receptor full or partial agonists elicit an anxiolytic-like effect in this procedure in most cases (approximately 2/3). However, compounds (triazolobenzodiazepines such as adinazolam and alprazolam, selective serotonin reuptake inhibitors) that have a different spectrum of therapeutic efficacy in anxiety disorders such as panic attacks, generalized anxiety disorder or obsessive-compulsive disorder were poorly effective as anxiolytics in the open field test, suggesting that this paradigm may not model features of anxiety disorders. The procedure is also relevant for the study of compounds endowed with anxiogenic effects, as such effects were detected after treatments with benzodiazepine receptor inverse agonists or with corticotropin releasing factor (CRF) receptor agonists.
Prut
Laetitia
L
EA3248, Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelias, Parc de Grandmont Avenue Monge, 37200 Tours, France.
Belzung
Catherine
C
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D023421:Models, Animal; D011963:Receptors, GABA-A / Q000187:drug effects; D018013:Receptors, Neuropeptide / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1
D014151:Anti-Anxiety Agents; D008024:Ligands; D011963:Receptors, GABA-A; D018013:Receptors, Neuropeptide; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1