Life after transcription--revisiting the fate of messenger RNA.
Recently, several groups have used high-density DNA microarrays to study mRNA turnover. These new data suggest that decay contributes significantly to determining mRNA levels, and they should prompt us to refocus our attention on the regulatory potential of mRNA decay.
Khodursky
Arkady B
AB
Dept of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, MN 55108, USA. khodu001@umn.edu
Bernstein
Jonathan A
JA
D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D012333:RNA, Messenger