title: [Evaluation of oxidoreductive potential of patients with neuroborreliosis].
abstract: OBJECTIVE
  The purpose of the study was to evaluate parameters of oxidoreductive system in serum and cerebrospinal fluid (CSF) of patients with neuroborreliosis.
  
  
  METHODS
  The cases were 25 patients aged 21 to 64 (x = 42.3) hospitalized with diagnosis of neuroborreliosis. Activity of superoxide dismutase (Cu, Zn-SOD), glutathione reductase (GSSG-R), glutathione peroxidase (GSH-Px) and concentration of sulphydryl groups (-SH) and malondialdehyde (MDA) in serum and CSF were tested. The control group consisted of 10 patients with diagnosis of discopathy. An examination was performed twice: before and after treatment.
  
  
  RESULTS
  Results of the study showed lack of stability in an oxidoreductive system during neuroborreliosis both in serum and in CSF. In CSF activity of SOD was increased while activity of GSH-Px and GSSG-R were decreased. Also concentration of -SH and lipid peroxidation products measured as MDA were increased. The increase of SOD, GSH-Px, GSSG-R activity and concentration of -SH and MDA in serum were detected.
  
  
  CONCLUSIONS
  Disorders of an oxidoreductive system in CSF and serum during neuroborreliosis were observed. These changes persisted despite treatment and normalization of inflammatory CSF markers.
authors.affiliation: Klinika Chorób Zakaźnych i Neuroinfekcji AM w Białymstoku.
authors.forename: Sławomir A
authors.initials: SA
authors.lastname: Pancewicz
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Skrzydlewska
authors.forename: Teresa
authors.initials: T
authors.lastname: Hermanowska-Szpakowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Stankiewicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000134:cerebrospinal fluid; D005980:Glutathione Reductase / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000134:cerebrospinal fluid; D008875:Middle Aged; D010088:Oxidoreductases / Q000097:blood* / Q000134:cerebrospinal fluid*; D011044:Poland / Q000453:epidemiology; D013482:Superoxide Dismutase / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase