title: New lignan glycosides from Chinese medicinal plant, Sinopodophillum emodi.
abstract: Two new podophillotoxin glucosides, L-picropodophillotpxin 7'-O-(beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside) (2) and L-picropodophillotpxin 7'-O-beta-D-glucopyranoside (3), were isolated from Chinese medicinal plant, Sinopodophillum emodi, together with 4 known compounds, podophillotoxin (1), podorhizol 4'-O-beta-D-glucopyranoside (4), deoxypodophillotoxin (5), and dehydropodophillotoxin (6). The structures of 2 and 3 were finally determined by the extensive decouping and nuclear Overhauser effect (NOE) experiments in NMR spectra and circular dichroism (CD) spectra. Compound 2 is the second example of podophillotoxin diglucoside, and both the first one and 2 were isolated from S. emodi. X-ray crystal structure analysis of 1, 5, and 6 was carried out. Compounds 1 and 5 showed the different conformations from those reported.
authors.affiliation: Biology Department, Northwest University, Xi'an, P. R. China.
authors.forename: Changqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Akito
authors.initials: A
authors.lastname: Nagatsu
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Hatano
authors.forename: Naohiro
authors.initials: N
authors.lastname: Shirai
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kato
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ogihara
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots; D011035:Podophyllum; D027343:Rhizome
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans