title: The relative influence of five variables on the in vitro wear rate of uncrosslinked UHMWPE acetabular cup liners.
abstract: The wear factors, k(exp)(in 10(-6)mm(3)N(-1)m(-1)), of two sets of hemispherical uncrosslinked ultra-high-molecular-weight polyethylene UHMWPE acetabular cup liners, when articulated against 28-mm-diameter Co-Cr alloy femoral heads, were determined in a hip joint wear simulator. All test conditions used were the same for both sets, with the exception that in one set (comprising six liners), the bovine serum concentration in the test lubricant (P) was 25vol%, while it was 90vol% for the other set (comprising seven liners). For each liner in each set, the values of the following independent or explanatory variables were determined: the tensile toughness (U, in MJm(-3)) of the UHMWPE; the degree of crystallinity (%C) of the UHMWPE; the mean surface roughness (R(a), in microm) of the liner; and the radial clearance between the femoral head and the liner (DeltaL, in mm). All the results in both sets were combined and correlational analyses were performed between k(exp), on the one hand, and various combinations of U, %C,R(a),DeltaL, and P, on the other hand. It was found that the strongest correlations were obtained when P was included, but that %C and U are also important variables. Within the range of values of the independent variables used, the recommended relationship isk(exp)=460U(0.72)%C(-5.29)P(-0.66)(adjustedr(2)=0.858). This relationship has many potential uses, such as for screening uncrosslinked UHMWPEs that are being considered as candidates for fabricating acetabular cup liners, and for conducting studies of the sensitivity of k(exp) to a change in a value of a specified independent variable (with the values of all the other independent variables held constant). These uses, as well as the study limitations, are discussed in detail.
authors.affiliation: Department of Mechanical Engineering, The University of Memphis, Memphis, TN 38152-3180, USA. glewis@memphis.edu
authors.forename: Gladius
authors.initials: G
authors.lastname: Lewis
authors.forename: Robert M
authors.initials: RM
authors.lastname: Fencl
authors.forename: Michael
authors.initials: M
authors.lastname: Carroll
authors.forename: Tim
authors.initials: T
authors.lastname: Collins
mesh_terms: D000465:Algorithms; D019544:Equipment Failure Analysis / Q000295:instrumentation / Q000379:methods*; D017276:Friction; D006622:Hip Prosthesis; D006801:Humans; D008422:Materials Testing / Q000295:instrumentation / Q000379:methods*; D015233:Models, Statistical; D011095:Polyethylenes / Q000737:chemistry*; D011475:Prosthesis Failure; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013314:Stress, Mechanical
chemical_list: D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene