title: Endocarditis due to glycopeptide-intermediate Staphylococcus aureus: case report and strain characterization.
abstract: We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus (VISA) that did not respond to high doses of vancomycin. Initial vancomycin MIC of the last isolate recovered from blood was 8 micro g/mL, but could be induced up to 32 micro g/mL by consecutive growing with vancomycin. Clinical response was only accomplished when linezolid was included in therapy.
authors.affiliation: Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
authors.forename: Soraya
authors.initials: S
authors.lastname: Andrade-Baiocchi
authors.forename: Maria Cristina B
authors.initials: MC
authors.lastname: Tognim
authors.forename: Otavio C G
authors.initials: OC
authors.lastname: Baiocchi
authors.forename: Helio S
authors.initials: HS
authors.lastname: Sader
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial; D004696:Endocarditis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010068:Oxacillin / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance
chemical_list: D014640:Vancomycin; D010068:Oxacillin