title: Mechanosensitive channels: stress relief.
abstract: Bacterial responses to decreasing osmolality involve mechanosensitive channels. The crystal structure has been determined of the small conductance mechanosensitive channel (MscS) from Escherichia coli, providing new insights into mechanical and voltage sensing by this and other channel proteins.
authors.affiliation: Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. phil@biop.ox.ac.uk
authors.forename: Philip C
authors.initials: PC
authors.lastname: Biggin
authors.forename: Mark S P
authors.initials: MS
authors.lastname: Sansom
mesh_terms: D004926:Escherichia coli / Q000737:chemistry / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology*; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*
chemical_list: D029968:Escherichia coli Proteins; D007473:Ion Channels; C469542:MscS protein, E coli