title: [Case report. Phenprocoumon (Marcumar, Falithrom) as an unusual reason for coumarin poisoning in a dog].
abstract: Coumarin poisoning in dogs is not unusual and is in most cases caused by warfarin, a coumarin derivative which is used as a rodenticide. Competitive inhibition of vitamin K with an incomplete synthesis of the coagulation factors II, VII, IX and X can lead to a significant bleeding tendency. We observed a 3-year old male West Highland White Terrier with a reduced general condition and dyspnoea together with a massive haemothorax. Administration of vitamin K1 (3 mg/kg) led to a rapid improvement of the condition. Coagulation analysis revealed a prolonged activated recalcification time (ARCT), prothrombin time (PT) and aPTT with uncharacteristic thrombin time (TT); factor II, VII and X activities were reduced while factor V activity was normal, all of which are characteristic for coumarin poisoning. HPLC did not reveal the presence of warfarin but of phenoprocoumon, a drug used for thromboembolic prophylaxis in humans. This observation has not been described for dogs to date.
authors.affiliation: Institut für Klinische Chemie und Pathobiochemie, Otto-von-Guericke-Universität Magdeburg.
authors.forename: G
authors.initials: G
authors.lastname: Lutze
authors.forename: W
authors.initials: W
authors.lastname: Römhild
authors.forename: J
authors.initials: J
authors.lastname: Elwert
authors.forename: J
authors.initials: J
authors.lastname: Leppelt
authors.forename: K
authors.initials: K
authors.lastname: Kutschmann
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000506:poisoning*; D001777:Blood Coagulation / Q000187:drug effects; D004283:Dog Diseases / Q000139:chemically induced* / Q000503:physiopathology; D004285:Dogs; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D010644:Phenprocoumon / Q000506:poisoning*; D011517:Prothrombin Time / Q000662:veterinary; D013918:Thrombin Time / Q000662:veterinary; D014813:Vitamin K Deficiency / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D000925:Anticoagulants; D010644:Phenprocoumon