title: Vehicle effects on in vitro skin permeation of thiocolchicoside.
abstract: Thiocolchicoside, a semi-synthetic derivative of colchicoside, is used in topical formulations for its anti-inflammatory and muscle-relaxant properties. The objective of this study was to evaluate the effect of a (propylene glycol diperlagonate) DPPG and (propylene glycol) PG mixture present in an innovative foam formulation (Miotens) on the flux of thiocolchicoside through excised human skin. Furthermore, the in vitro permeation behaviour of this new formulation (Miotens foam) was compared to another commercial product (Muscoril ointment) and to a control gel formulation (thiogel), both enhancer free. The best permeation profile was obtained from the foam formulation (Miotens) which was able to increase the thiocolchicoside flux about three fold compared to control formulation (thiogel) and about two fold compared to the commercial formulation Muscoril ointment.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Catania, Catania. boninaf@mbox.unict.it
authors.forename: F
authors.initials: F
authors.lastname: Bonina
authors.forename: C
authors.initials: C
authors.lastname: Puglia
authors.forename: D
authors.initials: D
authors.lastname: Trombetta
authors.forename: M C
authors.initials: MC
authors.lastname: Dragani
authors.forename: M M
authors.initials: MM
authors.lastname: Gentile
authors.forename: G
authors.initials: G
authors.lastname: Clavenna
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003078:Colchicine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D009824:Ointments; D014677:Pharmaceutical Vehicles; D010715:Phosphatidylglycerols; D011409:Propylene Glycols; D012869:Skin Absorption / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D008567:Membranes, Artificial; D009824:Ointments; D014677:Pharmaceutical Vehicles; D010715:Phosphatidylglycerols; D011409:Propylene Glycols; D003078:Colchicine; C004280:thiocolchicoside; C030345:1,2-dipalmitoylphosphatidylglycerol