[Neurogenic heart injuries and their pharmacological correction by a new taurine derivative].
An antiischemic effect of a new n-phenylalkyl derivative of taurine was shown in experiments with rats. The effect is predetermined by an improvement of energetic metabolism in the myocardium, by the restoration of the activity of energetic exchange enzymes and by a reduction of the lipid peroxidation intensity. Besides, it was found that the drug can inhibit the activity of cytokines (IL-l gamma, and TNF gamma), which can be of significant practical importance in the treatment of myocardial ischemia and chronic heart insufficiency.
Zafodskaia
I S
IS
Khnychenko
L K
LK
Sapronov
N S
NS
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*
D013654:Taurine