[Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].
OBJECTIVE
To observe the effects of chlorotriptolide (T4) and triptonide (T7) on the chromosome aberration and micronuclei rates of bone marrow cell in male SD rats.


METHODS
Antifertility doses of T4[80 micrograms/(kg.d)] or T7[317 micrograms/(kg.d)] were given to male rats per OS for 10 weeks. Bone marrow slides were then prepared and compared with the controls.


RESULTS
The chromosome aberration and micronuclei rates were not significantly different from those of the controls (P > 0.05).


CONCLUSIONS
The results were in accordance with our previous reports about the effects of T4 and T7 on the chromosome aberration and micronuclei rates of rat spermatogenic cells. At the antifertility doses, T4 and T7 did not show a mutagenic effect.
Zhang
Jian-Wei
JW
Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China.
Liu
Qi-Lan
QL
Lin
Ning
N
Xu
Ye
Y
Qian
Shao-Zhen
SZ
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004224:Diterpenes / Q000494:pharmacology*; D004852:Epoxy Compounds; D007248:Infertility, Male / Q000139:chemically induced / Q000235:genetics; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D010616:Phenanthrenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D029757:Tripterygium / Q000737:chemistry; D014315:Triterpenes / Q000494:pharmacology*
D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D014315:Triterpenes; C001899:triptolide; C084079:triptonide