Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients.
One hundred forty-six hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients were followed up for 32 +/- 13 months. All six patients with hepatocellular carcinoma had hepatitis B virus (HBV) genotype C. Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion.
Chan
Henry Lik-Yuen
HL
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. hlychan@hotmail.com
Wong
May Ling
ML
Hui
Alex Yui
AY
Hung
Lawrence Cheung-Tsui
LC
Chan
Francis Ka-Leung
FK
Sung
Joseph Jao-Yiu
JJ
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000150:complications / Q000473:pathology*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008297:Male
D000956:Antigens, Viral; D006513:Hepatitis B e Antigens