Antifungal activities of N-arylbenzenesulfonamides against phytopathogens and control efficacy on wheat leaf rust and cabbage club root diseases.
A set of N-arylbenzenesulfonamides with various substituents at the arylamine and benzenesulfonyl positions were prepared, and their antifungal properties were measured in vitro against such plant pathogenic fungi as Pythium ultimum, Phytophthora capsici, Rhizoctonia solani, and Botrytis cinerea. Compounds 3, 4, 8, 9, 10, 14, 16, 18, 20, 21, 24 and 27 had antifungal activity over a broad spectrum of the phytopathogenic fungi tested, where 50% of inhibition (ED50) was in the range of 3-15 microg/ml. Based on the in vitro activity, six derivatives (3, 4, 10, 18, 21 and 27) were selected and tested further for their fungicidal efficacy in vivo. The fungicidal efficacy of 10, 21 and 27 had a disease control value of over 85% at 50 microg/ml against wheat leaf rust, while that of 4 was selective against cabbage club root disease.
Kang
Jae Gon
JG
Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University, Chinju 660-701, Korea.
Hur
Jong Hyun
JH
Choi
Sung Jun
SJ
Choi
Gyung Ja
GJ
Cho
Kwang Yun
KY
Ten
Leonid N
LN
Park
Ki Hun
KH
Kang
Kyu Young
KY
D000935:Antifungal Agents / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects; D001937:Brassica / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D005659:Fungicides, Industrial / Q000494:pharmacology; D015394:Molecular Structure; D010838:Phytophthora / Q000187:drug effects; D010935:Plant Diseases / Q000382:microbiology*; D018515:Plant Leaves / Q000382:microbiology; D018517:Plant Roots / Q000382:microbiology; D011775:Pythium / Q000187:drug effects; D012232:Rhizoctonia / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology*; D014908:Triticum / Q000382:microbiology*
D000935:Antifungal Agents; D005659:Fungicides, Industrial; D013449:Sulfonamides