title: HPFP, a model propellant for pMDIs.
abstract: A novel model propellant for the study of the properties of pMDIs (pressurized metered-dose inhalers) at atmospheric pressure is proposed and extensively characterized. The reasons for the choice of this liquid, with its advantages and drawbacks, are explained and justified. Comparison with existing fluorinated propellants is also documented.
authors.affiliation: Pharmaceutical and Analytical Research & Development, AstraZeneca R&D Charnwood, Loughborough, UK. philippe.rogueda@astrazeneca.com
authors.forename: Philippe G A
authors.initials: PG
authors.lastname: Rogueda
mesh_terms: D000335:Aerosol Propellants / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003720:Densitometry; D005079:Excipients / Q000737:chemistry; D005466:Fluorocarbons / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D036501:Metered Dose Inhalers; D012031:Refractometry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013500:Surface Tension; D014867:Water / Q000737:chemistry; D010420:Pentanes
chemical_list: D000335:Aerosol Propellants; D005079:Excipients; D005466:Fluorocarbons; D006845:Hydrocarbons, Fluorinated; D014867:Water; C008806:perfluoropentane; D010420:Pentanes; C094049:apaflurane