Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke.
BACKGROUND
Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of interleukin (IL)-10 and IL-4 in deteriorating ischemic stroke.


METHODS
Two hundred thirty-one patients with ischemic stroke within the first 24 hours from onset were included. Neurological worsening was defined when the Canadian Stroke Scale score fell at least 1 point during the first 48 hours after admission. Anti-inflammatory cytokines were determined in plasma obtained on admission.


RESULTS
Eighty-three patients (35.9%) worsened within the first 48 hours after stroke onset. Significantly lower concentrations of IL-10 were found in patients with neurological worsening (P<0.05), but IL-4 levels were similar in patients with or without deterioration. Lower plasma concentrations of IL-10 (<6 pg/mL) were associated with clinical worsening on multivariate analysis (odds ratio=3.1, 95% CI=1.1 to 8.9) independently of hyperthermia, hyperglycemia, or neurological condition on admission. Further analysis disclosed that early worsening was independently associated with lower IL-10 plasma levels in patients with subcortical infarcts or lacunar stroke but not in patients with cortical lesions.


CONCLUSIONS
Anti-inflammatory cytokine IL-10 is associated with the early clinical course of patients with acute ischemic stroke, especially in patients with small vessel disease or subcortical infarctions.
Vila
Nicolás
N
Hospital Clínic, Clinical Institute of Nervous System Diseases, Instituto Investigaciones Biomédicas August Pi i Sunyer, Villaroel 170, 08036 Barcelona, Spain.
Castillo
José
J
Dávalos
Antonio
A
Esteve
Anna
A
Planas
Anna M
AM
Chamorro
Angel
A
D000208:Acute Disease; D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D025461:Feedback, Physiological; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
D016207:Cytokines; D016753:Interleukin-10; D015847:Interleukin-4