title: Study on tooth development, past, present, and future.
abstract: For decades, the understanding of craniofacial development has been a central issue in odontology and developmental biology. As a consequence, a significant number of deformities are being studied for their variety of genotype and phenotype. Although there is little doubt about the essential roles of homeobox genes, transcription factors, and growth factors, we now know at least the fundamental strategy of craniofacial biology. The tooth as an organ performs a whole range of functions, each of which is truly indispensable for the maintenance of life. The possession of teeth is, therefore, obviously coupled with the complication of the natural structure of an individual organism. In the following, we shall focus on a brief history of tooth studies and some suggestions for obtaining a full understanding of teeth in the future.
authors.affiliation: Department of Oral Biology, College of Dentistry, Institute of Life Science and Biotechnology, Brain Korea 21 Project of Medical Sciences, Yonsei University, Seoul, Korea. hsjung@yumc.yonsei.ac.kr
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Jung
authors.forename: Yamamoto
authors.initials: Y
authors.lastname: Hitoshi
authors.forename: Hee-Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009024:Morphogenesis; D009805:Odontogenesis; D012106:Research / Q000639:trends; D014070:Tooth / Q000196:embryology* / Q000254:growth & development*