title: Effect of honey on carbamazepine kinetics in rabbits.
abstract: The study was undertaken to determine the effect of honey on carbamazepine kinetics in rabbits. The study was done on three occasions in each animal. Study 1 was carried out after single dose administration of carbamazepine (80 mg/kg, po), along with saline (2.34 ml/kg, po). After a wash out period of one week, the second study was carried out by co-administration of carbamazepine with honey (2.34ml/kg, po). After this, the animals continued to receive honey (2.34ml/kg, po), once daily, for 7 days. On the eighth day of honey treatment, the carbamazepine kinetics was studied again. Pharmacokinetic analysis revealed that single as well as multiple dose honey treatment showed a significant decrease in area under the plasma time concentration curve (AUC) when compared with saline treated control. A significant increase in the clearance (CL/F) rate of carbamazepine was observed only after multiple dose honey treatment. Both single and multiple dose honey treatment did not show any significant effect on other pharmacokinetic parameters like t1/2, Cmax, Tmax and Vd when compared with saline treated group. Data thus obtained suggested that honey decreases the bioavailability of carbamazepine.
authors.affiliation: Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006.
authors.forename: K
authors.initials: K
authors.lastname: Koumaravelou
authors.forename: C
authors.initials: C
authors.lastname: Adithan
authors.forename: C H
authors.initials: CH
authors.lastname: Shashindran
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asad
authors.forename: Benny K
authors.initials: BK
authors.lastname: Abraham
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002220:Carbamazepine / Q000493:pharmacokinetics*; D018565:Food-Drug Interactions; D006207:Half-Life; D006722:Honey; D011817:Rabbits
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine