[The influence of transdermal nitroglycerin patches on fetal blood flow parameters in threatened preterm labor].
OBJECTIVE
The aim of our study was the assessment of fetal arterial Doppler parameters (umbilical artery and middle cerebral artery) in threatened preterm labor in the course of transdermal nitroglycerin therapy.


METHODS
16 pregnant women in between 27th and 34th week of gestation with symptoms of threatening preterm labor were brought into our study. Patients were treated with transdermal nitroglycerin (5 mg) patches. Maternal blood pressure. Manning's test score and fetal arterial Doppler blood flow were measured.


RESULTS
Whereas maternal systolic blood pressure does not vary in the course of therapy, significant decrease in diastolic blood pressure was noted. There was no change in the mean umbilical and middle cerebral artery blood flow in the course of treatment.


CONCLUSIONS
Nitroglycerin in the form of transdermal therapeutic system releasing nitric oxide doesn't effect fetal artery Doppler parameters. Nitroglycerin may be used as a safe therapeutic agent in treatment of preterm labor.
Leszczyńska-Gorzelak
Bozena
B
Kliniki Połoznictwa i Perinatologii AM w Lublinie, kierownik Kliniki.
Marciniak
Beata
B
Laskowska
Marzena
M
Sławatyński
Andrzej
A
Oleszczuk
Jan
J
D000279:Administration, Cutaneous; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D005996:Nitroglycerin / Q000008:administration & dosage*; D007752:Obstetric Labor, Premature / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D015149:Tocolytic Agents / Q000008:administration & dosage*; D016896:Treatment Outcome; D014463:Ultrasonography; D014590:Uterine Contraction / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage*
D015149:Tocolytic Agents; D014665:Vasodilator Agents; D005996:Nitroglycerin