Adjuvant activity of alum in inducing antigen specific IgE antibodies in BALB/c mice: a reevaluation.
The IgE production was compared in the presence and absence of aluminum hydroxide gel (alum). Without alum, the IgE production was induced within a suitable range of the antigen dosage; however, alum enhanced it. Alum did not affect the minimum requirement for the antigen dosage, indicating that alum may not take part in the efficiency of antigen presentation.
Yamanishi
Rintaro
R
Department of Nutrition, School of Medicine, University of Tokushima, Kuramoto-cho 3-18-15, Tokushima-shi, Tokushima 770-8503, Japan. rintaro@nutr.med.tokushima-u.ac.jp
Yusa
Ikuko
I
Bando
Noriko
N
Terao
Junji
J
D000276:Adjuvants, Immunologic; D000534:Alum Compounds / Q000494:pharmacology*; D000818:Animals; D000918:Antibody Specificity; D004797:Enzyme-Linked Immunosorbent Assay; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D007074:Immunoglobulin G; C041524:aluminum sulfate; D007073:Immunoglobulin E; D010047:Ovalbumin