title: Improving scar quality: a prospective clinical study.
abstract: Following traumatic or surgical injury to the skin, wounds do not heal by tissue regeneration but rather by scar formation. Though healing is definitely a welcomed event, the resultant scar, very often, is not aesthetically pleasing, and not infrequently, may be pathologic causing serious deformities and contractures. Management of problematic scars continues to be a frustrating endeavor with less than optimal results. Prophylactic methods of wound management to minimize serious scarring are being developed. In a previously published study, we have demonstrated improved healing of split thickness skin graft donor sites following treatment with Moist Exposed Burn Ointment (MEBO, Julphar Gulf Pharmaceutical Industries, Ras Al-Khaimah, UAE). At present, we are reporting the results of a comparative clinical prospective study evaluating scar quality following primary healing of elective surgical and traumatic facial wounds with prophylactic MEBO application, topical antibiotic ointment application, and no topical therapy at all. Scars were evaluated according to the Visual Analogue Scale for scar assessment. Statistical analysis of scar assessment scores demonstrated marked prevention of unfavorable scars with improved cosmetic results following MEBO prophylactic therapy.
authors.affiliation: Division of Plastic and Reconstructive Surgery, American University of Beirut, Lebanon. aata@terra.net.lb
authors.forename: Bishara S
authors.initials: BS
authors.lastname: Atiyeh
authors.forename: John
authors.initials: J
authors.lastname: Ioannovich
authors.forename: Christian A
authors.initials: CA
authors.lastname: Al-Amm
authors.forename: Kusai A
authors.initials: KA
authors.lastname: El-Musa
authors.forename: Ruwayda
authors.initials: R
authors.lastname: Dham
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control*; D062109:Dermatologic Surgical Procedures; D005145:Face / Q000601:surgery; D005672:Fusidic Acid / Q000008:administration & dosage; D006801:Humans; D009824:Ointments / Q000627:therapeutic use*; D011446:Prospective Studies; D012855:Sitosterols / Q000627:therapeutic use*; D012867:Skin / Q000503:physiopathology; D013537:Sutures; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D009824:Ointments; D012855:Sitosterols; C472006:moist exposed burn ointment; D005672:Fusidic Acid