title: Cosmetic applications for solid lipid nanoparticles (SLN).
abstract: Solid lipid nanoparticles (SLN) are novel delivery systems for pharmaceutical and cosmetic active ingredients. This paper highlights advantages of SLN for cosmetic applications. The dependence of the occlusive effect on the particle size of SLN due to film formation is presented by in vitro data. An in vivo study showed that addition of 4% SLN to a conventional o/w cream lead to an increase of skin hydration of 31% after 4 weeks. The application of SLN as physical sunscreens and as active carriers for molecular sunscreens has also been investigated. The amount of molecular sunscreen could be decreased by 50% while maintaining the protection level compared to a conventional emulsion.
authors.affiliation: Institut für Pharmazie, Pharmazeutische Technologie, Biopharmazie und Biotechnologie, Freie Universität Berlin, Kelchstrasse 31, D-12169 Berlin, Germany.
authors.forename: Sylvia A
authors.initials: SA
authors.lastname: Wissing
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Müller
mesh_terms: D000287:Administration, Topical; D002626:Chemistry, Pharmaceutical; D003358:Cosmetics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry*; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry*; D008863:Microspheres; D036103:Nanotechnology; D010316:Particle Size; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D013473:Sunscreening Agents / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D003358:Cosmetics; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D013473:Sunscreening Agents