[Screening of benzodizepines and their metabolites in urine].
OBJECTIVE
Screen seventeen benzodizepines and their metabolitesin urine by GC/ECD and GC/MS.


METHODS
They were GC (GC/ECD, GC/MS) assay of benzodizepines and GC (GC/ECD, GC/MS) assay of benzophenones of acid-hydrolytic products of 1,4-benzodizepines.


RESULTS
The methods were simple and sensitive. The recoverys were 60% to 90% of most benzodizepines, linear calibration curves were 20 ng/ml-200 ng/ml (r > 0.99), and detection limits were 0.5 ng/ml-10 ng/ml.


CONCLUSIONS
They methods were evaluated with human urine samples.
Shen
Bao-hua
BH
Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063.
Shen
Min
M
Zhuo
Xian-yi
XY
D014151:Anti-Anxiety Agents / Q000378:metabolism / Q000652:urine*; D001569:Benzodiazepines / Q000378:metabolism / Q000652:urine*; D001577:Benzophenones / Q000378:metabolism / Q000652:urine; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
D014151:Anti-Anxiety Agents; D001577:Benzophenones; D001569:Benzodiazepines