title: MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.
abstract: The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. ctempany@bwh.harvard.edu
authors.forename: Clare M C
authors.initials: CM
authors.lastname: Tempany
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.forename: Nathan
authors.initials: N
authors.lastname: McDannold
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Quade
authors.forename: Ferenc A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000328:Adult; D001833:Body Temperature Regulation / Q000502:physiology; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D011446:Prospective Studies; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation*; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000628:therapy*