Sib 1893 possesses pro- and anticonvulsant activity in the electroshock seizure threshold test in mice.
SIB 1893, a non-competitive antagonist of group I metabotropic glutamate receptor subtype 5, administered at the doses ranging between 0.5-2 mg/kg markedly lowered the electroconvulsive threshold, whereas if applied at the higher dose of 40 mg/kg, it significantly raised the threshold for electroconvulsions in mice, exhibiting both pro- and anticonvulsive properties in this test.
Luszczki
Jarogniew
J
Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Borowicz
Kinga K
KK
Czuczwar
Stanisław J
SJ
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051379:Mice; D011725:Pyridines / Q000009:adverse effects / Q000494:pharmacology*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control*
D000927:Anticonvulsants; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C120148:SIB 1893