title: Reversible posterior leukoencephalopathy syndrome in children with cancers.
abstract: We report three cases of reversible posterior leukoencephalopathy syndrome (RPLS) in children with cancers. All patients presented with sudden confusional state, visual disturbance, and transient mild hypertension under the treatment of childhood cancers. Magnetic resonance imaging of the brain demonstrated cortical and subcortical lesions predominantly in the occipital region, which showed high intensity signal on fluid-attenuated inversion recovery images. All patients completely recovered from their neuropsychologic deficits only with antihypertensive therapy or discontinuation of the possible offending drugs. Early recognition of RPLS as a complication during cancer therapy in childhood may facilitate precise diagnosis and appropriate treatment.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Suminoe
authors.forename: Akinobu
authors.initials: A
authors.lastname: Matsuzaki
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kira
authors.forename: Nami
authors.initials: N
authors.lastname: Fukunaga
authors.forename: Toshinori
authors.initials: T
authors.lastname: Nishio
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hoshina
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents