Intra-cerebral relapse following prolonged remission after autologous stem cell transplantation for multiple myeloma.
Central nervous system (CNS) myeloma is a rare phenomenon, especially so after high-dose therapy (HDT) and stem cell transplantation. We describe a case of isolated CNS relapse of myeloma post autologous transplantation that followed a prolonged progression-free interval. Issues regarding the pathophysiology and management of this unusual complication are discussed.
Seftel
M D
MD
Leukemia/BMT Program of British Columbia (B.C.), Division of Hematology, Vancouver Hospital and Health Sciences Centre, JPP3, 950 West 10th Avenue, B.C. Cancer Agency, University of B.C., Vancouver, B.C., Canada V5Z 4E3. mseftel@bccancer.bc.ca
Maguire
J
J
Voss
N
N
Woodhurst
W B
WB
Dalal
B I
BI
Shepherd
J D
JD
D001932:Brain Neoplasms / Q000209:etiology*; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D012008:Recurrence; D012074:Remission Induction; D014182:Transplantation, Autologous