Effects of Alzheimer's disease on the recognition of novel versus familiar words: neuropsychological and clinico-metabolic data.
This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995) procedure. Results showed that both groups exhibited more hits and more false alarms for familiar than for novel words. The groups did not differ in the recognition of familiar words, reflecting preserved familiarity processes in AD. However, AD patients made more false alarms than NCs in the recognition of novel words, reflecting impairment of recollection processes in AD. A positron emission tomography analysis of clinico-metabolic correlations in AD patients showed a correlation between recognition of novel words and right hippocampal activity, whereas recognition of familiar words was more related to metabolic activity in the left posterior orbitofrontal cortex.
Lekeu
Françoise
F
U Liège.
Van der Linden
Martial
M
U Liège.
Degueldre
Christian
C
U Liège.
Lemaire
Christian
C
U Liège.
Luxen
André
A
U Liège.
Franck
Georges
G
U Hosp of Liège.
Moonen
Gustave
G
U Liège.
Salmon
Eric
E
0000-0003-2520-9241
U Liège.
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology*; D001931:Brain Mapping; D003210:Concept Formation / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D012153:Retention, Psychology / Q000502:physiology; D014055:Tomography, Emission-Computed; D014706:Verbal Learning / Q000502:physiology*