title: The use of lymecycline in the treatment of moderate to severe acne vulgaris: a comparison of the efficacy and safety of two dosing regimens.
abstract: We compared the efficacy and safety of lymecycline 300 mg od vs lymecycline 150 mg bid or placebo in the treatment of moderate to severe acne. 271 patients received either oral lymecycline 300 mg od + placebo od, lymecycline 150 mg bid, or placebo bid, for 12 weeks. Reduction in inflammatory lesion counts at week 12 was the primary efficacy variable (global improvement was a primary efficacy parameter vs placebo) and safety was assessed by adverse events. Lymecycline 300 mg od was non-inferior to lymecycline 150 mg bid at all time points and superior to placebo throughout the study. Drug-related adverse events were similar for all treatment groups. Lymecycline 300 mg od is as effective and safe as lymecycline 150 mg bid in the treatment of moderate to severe acne. This new, once daily formulation could potentially contribute towards improved compliance rates with oral tetracyclines.
authors.affiliation: Hôpital St Louis, 1 Av. Claude Vellefaux, 75475 Paris, France. elisabeth.treillard@sls.ap-hop-paris.fr
authors.forename: Louis
authors.initials: L
authors.lastname: Dubertret
authors.forename: Mohsen
authors.initials: M
authors.lastname: Alirezai
authors.forename: Gilles
authors.initials: G
authors.lastname: Rostain
authors.forename: Morad
authors.initials: M
authors.lastname: Lahfa
authors.forename: Dan
authors.initials: D
authors.lastname: Forsea
authors.forename: Bogdan Dimitrie
authors.initials: BD
authors.lastname: Niculae
authors.forename: Margit
authors.initials: M
authors.lastname: Simola
authors.forename: Attila
authors.initials: A
authors.lastname: Horvath
authors.forename: Fabienne
authors.initials: F
authors.lastname: Mizzi
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008194:Lymecycline / Q000008:administration & dosage*; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D008194:Lymecycline