title: Computed tomography-guided salvage brachytherapy of recurrent large nonresectable familial colo-rectal cancer in the pelvis: case report.
abstract: Here we present the first reported case of three-dimensional CT-guided salvage brachytherapy of recurring colorectal cancer in the pelvis after failed radiation therapy, total colectomy, and chemotherapy. Initial CEA was 67.0 ng/mL and tumor volume 93 cm3 with no metastasis outside the pelvis. A total of 333 seeds of Iodine-125 were delivered to the entire target, with dosage of 150 to 200 Gy as calculated by post-implant CT dosimetry with Varian MMS software. CEA 12 months after implant decreased to 5.7 ng/mL. Clinical and biochemical results are encouraging; however long-term data in a greater universe of patients are required.
authors.affiliation: Uro-Radiology Prostate Institute, Vienna, VA 22182, USA. pgk@prostate-ca.com
authors.forename: Panos G
authors.initials: PG
authors.lastname: Koutrouvelis
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000532:radiotherapy*; D000293:Adolescent; D001918:Brachytherapy / Q000379:methods*; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery; D009367:Neoplasm Staging / Q000379:methods; D010388:Pelvis / Q000528:radiation effects; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D016879:Salvage Therapy / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes