title: Thalidomide in myelofibrosis with myeloid metaplasia: a pooled-analysis of individual patient data from five studies.
abstract: Trials to determine the effect of thalidomide in patients with Myelofibrosis with Myeloid Metaplasia (MMM) have produced inconclusive results due to different criteria for response and heterogeneous study participants. We undertook a pooled-analysis to assess the effects of such treatment on a larger series of cases and with a uniform assessment of response. We used updated data on 62 individual patients from 5 phase II trials that evaluated thalidomide therapy in MMM patients. Responsewas judged on individual disease parameters, on the improvement of the Dupriez risk categories and on the improvement of a 6 point "severity score" based on myeloproliferative and myelodepletive indexes of the disease. Overall, using standard dose of thalidomide, i.e. starting with no less than 100 mg/day, 49 patients (79%) had more than 4 weeks of therapy. Twenty-nine percent of patients with moderate to severe anemia showed an increase in hemoglobin or reduction/abolishment of blood transfusion requirements, 38% with moderate to severe thrombocytopenia had an increase in platelet counts, and 41% with high grade splenomegaly demonstrated a measurable reduction in splenic size. These effects led to an absolute decrease in the "severity" score in 44.9% of the patients. Major disease severity and high degrees of splenomegaly before therapy predicted response with a probability of 61.9%. However, worsening of the "severity" score was observed in 20.4% of the patients, 18% having a "myeloproliferative reaction" with leukocytosis and/or thrombocytosis. Sixty-six percent of the patients discontinued the drug before 6 months of treatment due to intolerance. In conclusion, there is a small but clear improvement of disease severity with thalidomide therapy in MMM. The potential for myeloproliferative reactions and the unfavorable dose-related toxicity profile argue for future studies using lower doses of this drug.
authors.affiliation: Laboratorio di Informatica Medica, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy. barosig@smatteo.pv.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barosi
authors.forename: Barosi
authors.initials: B
authors.lastname: Giovanni
authors.forename: Michelle
authors.initials: M
authors.lastname: Elliott
authors.forename: Elliott
authors.initials: E
authors.lastname: Michelle
authors.forename: Letizia
authors.initials: L
authors.lastname: Canepa
authors.forename: Canepa
authors.initials: C
authors.lastname: Letizia
authors.forename: Filippo
authors.initials: F
authors.lastname: Ballerini
authors.forename: Ballerini
authors.initials: B
authors.lastname: Filippo
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Piccaluga
authors.forename: Piccaluga
authors.initials: P
authors.lastname: Pier Paolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Visani
authors.forename: Visani
authors.initials: V
authors.lastname: Giuseppe
authors.forename: Monia
authors.initials: M
authors.lastname: Marchetti
authors.forename: Marchetti
authors.initials: M
authors.lastname: Monia
authors.forename: Gabriele
authors.initials: G
authors.lastname: Pozzato
authors.forename: Pozzato
authors.initials: P
authors.lastname: Gabriele
authors.forename: Francesca
authors.initials: F
authors.lastname: Zorat
authors.forename: Zorat
authors.initials: Z
authors.lastname: Francesca
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
authors.forename: Tefferi
authors.initials: T
authors.lastname: Ayalew
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D017322:Clinical Trials, Phase II as Topic; D005260:Female; D006454:Hemoglobins / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000139:chemically induced; D010976:Platelet Count; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013163:Splenomegaly / Q000209:etiology; D013792:Thalidomide / Q000627:therapeutic use* / Q000633:toxicity; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D006454:Hemoglobins; D013792:Thalidomide