New approach to a novel axially chiral ligand showing spontaneous enrichment of axial chirality.
We have synthesized novel axially chiral ligand with two chiral centers, (R)-(R)(2)- and (S)-(S)(2)-2,2'-bis(2,2,2-trifluoro-1-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kinetic and thermodynamic resolution is presented which gave these ligands in a much shorter steps, in a higher yield, and in a higher enantiomeric excess.
Hasegawa
Tomokuni
T
Faculty of Pharmaceutical Sciences, Hirakata, Japan.
Omote
Masaaki
M
Sato
Kazuyuki
K
Ando
Akira
A
Kumadaki
Itsumaro
I
D008024:Ligands; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D008024:Ligands; D004364:Pharmaceutical Preparations