title: Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.
abstract: This study investigated alleviation of streptomycin-induced vestibulotoxicity by edaravone in guinea pigs. Edaravone, a free radical scavenger, has potent free radical quenching action and is used in clinical practice to treat cerebral infarction. Streptomycin was administered to the inner ear by osmotic pump for 24 h, and edaravone (n=8) or saline (n=6) was intraperitoneally injected once a day for 7 days. We observed horizontal vestibulo-ocular reflex as a marker of postoperative vestibular function. Animals injected with saline showed statistically smaller gains than those injected with edaravone. These results suggest that edaravone suppresses streptomycin-induced vestibulotoxicity.
authors.affiliation: Department of Otolaryngology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Yamaguchi 755-8505, Ube, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Horiike
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimogori
authors.forename: Takuo
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077553:Edaravone; D006168:Guinea Pigs; D008297:Male; D009760:Nystagmus, Physiologic / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects; D013307:Streptomycin / Q000633:toxicity; D015837:Vestibular Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D014724:Vestibular Function Tests / Q000379:methods; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D020011:Protective Agents; D000077553:Edaravone; D000983:Antipyrine; D013307:Streptomycin