Preliminary experience with the use of recombinant factor VIIa to treat coagulation disturbances in pediatric patients.
OBJECTIVE
This study evaluates the efficacy of recombinant factor VII (rVIIa) in the treatment of coagulation dysfunction in pediatric patients.


METHODS
We retrospectively reviewed the records of pediatric patients who received rVIIa in the intensive care unit or operating room for treatment of coagulopathy. Case series in the literature were also reviewed.


RESULTS
Ten patients, ranging in age from 3 months to 19 years, received 22 doses of rVIIa. Seven of the 10 patients had received fresh frozen plasma and cryoprecipitate before the administration of rVIIa without effect. All 10 patients had a fibrinogen level above 100 mg/dl and platelet count above 100,000/mm3 at the time of rVIla administration. After rVIIa administration, there were significant decreases in prothrombin time, international normalized ratio, and partial thromboplastin time. No adverse effects were noted.


CONCLUSIONS
Recombinant factor VIIa can be used to effectively reverse coagulation disturbances in the pediatric patient even when treatment with fresh frozen plasma has failed. Given its therapeutic potential, prospective, randomized trials are warranted.
Tobias
Joseph D
JD
Department of Anesthesiology, University of Missouri, Columbia, MO 65212, USA. Tobiasj@health.missouri.edu
Groeper
Kelly
K
Berkenbosch
John W
JW
D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010976:Platelet Count; D011517:Prothrombin Time; D012189:Retrospective Studies; D016896:Treatment Outcome
D015942:Factor VIIa