title: Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.
abstract: The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan. mori@hoku-iryo-u.ac.jp
authors.forename: Yoki
authors.initials: Y
authors.lastname: Mori
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kamata
authors.forename: Noriko
authors.initials: N
authors.lastname: Toda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Koh-ichi
authors.initials: K
authors.lastname: Seki
authors.forename: Shinji
authors.initials: S
authors.lastname: Taneda
authors.forename: Shin
authors.initials: S
authors.lastname: Yoshino
authors.forename: Akiyo
authors.initials: A
authors.lastname: Sakushima
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Sakata
authors.forename: Akira K
authors.initials: AK
authors.lastname: Suzuki
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001158:Arteries / Q000187:drug effects; D007551:Isotonic Contraction / Q000187:drug effects; D009596:Nitrophenols / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D014664:Vasodilation / Q000187:drug effects*; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D009596:Nitrophenols; D001335:Vehicle Emissions