title: Emerging viruses: the case 'hantavirus'.
abstract: This review briefly summarises the recent knowledge about hantavirus infections and raises particular problems in hantavirus research that need further investigation. The following questions are addressed: (i) are hantaviruses distributed worldwide and what leads to new outbreaks, (ii) what is known about hantavirus evolution, (iii) how can hantavirus species be defined, (iv) what are the determinants of hantavirus pathogenesis in humans, and (v) what problems are associated with the development of new vaccines and antiviral therapeutics.
authors.affiliation: Institute of Virology, Humboldt University, Charité Medical School, Berlin, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Ulrich
authors.forename: Brian
authors.initials: B
authors.lastname: Hjelle
authors.forename: Christian
authors.initials: C
authors.lastname: Pitra
authors.forename: Detlev H
authors.initials: DH
authors.lastname: Krüger
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D005075:Biological Evolution; D004196:Disease Outbreaks; D006476:Orthohantavirus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D018778:Hantavirus Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines