title: Clinical applications of proton MR spectroscopy in oncology.
abstract: Proton magnetic resonance spectroscopy (H1-MRS) has been increasingly receiving more attention from radiologists, neurosurgeons, radiation and medical oncologists in the "in situ" clinical evaluation of human tumors. The utilization of H1-MRS, especially in human brain tumors, coupled to both routine magnetic resonance imaging (MRI) and functional MRI techniques provides greater information concerning tumor grading and extension and characterization of the normal surrounding tissue than what is possible with any other imaging technique alone. In this paper, we will review the current status of proton MR spectroscopy with emphasis on its clinical utility to diagnose tumors, its utility in planning surgical and radiation therapy interventions, and in its use in monitoring tumor treatment.
authors.affiliation: Department of Radiology, Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Chapel Hill NC 27599-7515, USA. Kwock@med.unc.edu
authors.forename: Lester
authors.initials: L
authors.lastname: Kwock
authors.forename: J Keith
authors.initials: JK
authors.lastname: Smith
authors.forename: Mauricio
authors.initials: M
authors.lastname: Castillo
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Ewend
authors.forename: Sharon
authors.initials: S
authors.lastname: Cush
authors.forename: Thomas
authors.initials: T
authors.lastname: Hensing
authors.forename: Mahesh
authors.initials: M
authors.lastname: Varia
authors.forename: David
authors.initials: D
authors.lastname: Morris
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Bouldin
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011522:Protons
chemical_list: D011522:Protons