[Effect of combined administration of acetylsalicylic acid and antioxidants on cellular and plasma hemostasis].
It was found that upsovit (acetylsalicylic acid, 330 mg; ascorbic acid, 200 mg), composition 1 (acetylsalicylic acid, 330 mg; ascorbic acid, 200 mg; hypoxen, 50 mg), and composition 2 (acetylsalicylic acid, 330 mg; ascorbic acid, 200 mg; hypoxen, 100 mg) inhibit thrombocyte aggregation in vitro. Hypoxen per se induces the aggregation of thrombocytes, but inhibited the ADP aggregation. Intravenous injections of upsovit in rabbits did not influence the ADP aggregation, but inhibited the collagen aggregation, while composition 2 inhibited the aggregation processes of both types. Besides, the intravenous injections of upsovit decreased the thromboplastin time and the activated partial thromboplastin time (APTT) and reduced the protein C activity, while influencing neither the heparin cofactor activity of antithrombin III nor the level of fibrinogen and its degradation products. In contrast, composition II did not change the thromboplastin time, APTT, and the protein C activity, but increased the heparin cofactor activity.
Makarov
V A
VA
Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167 Russia.
Petrukhina
G N
GN
Remov
M N
MN
Miftakhova
N T
NT
Kuz'mich
M K
MK
Popov
V G
VG
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D001780:Blood Coagulation Tests; D004338:Drug Combinations; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D000975:Antioxidants; D004338:Drug Combinations; D001241:Aspirin