Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia.
Lucas
Guilherme
G
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.
Hendolin
Panu
P
Harkany
Tibor
T
Agerman
Karin
K
Paratcha
Gustavo
G
Holmgren
Carl
C
Zilberter
Yuri
Y
Sairanen
Mikko
M
Minichiello
Liliana
L
Castren
Eero
E
Ernfors
Patrik
P
D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005799:Genes, Dominant; D066298:In Vitro Techniques; D008125:Locus Coeruleus / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D010147:Pain Measurement / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D020813:Receptor, trkB / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D017450:Receptors, Opioid, mu / Q000378:metabolism; D014279:Trigeminal Nucleus, Spinal / Q000187:drug effects / Q000378:metabolism
D000701:Analgesics, Opioid; D009414:Nerve Growth Factors; D017450:Receptors, Opioid, mu; D009270:Naloxone; D009020:Morphine; D020813:Receptor, trkB; C073922:neurotrophin 4