title: Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A.
abstract: There is a strong association between serum antibody responses to toxin A and protection against Clostridium difficile diarrhea. A parenteral C. difficile toxoid vaccine induced very-high-level responses to anti-toxin A immunoglobulin G (IgG) in the sera of healthy volunteers. After vaccination, the concentrations of anti-toxin A IgG in the sera of all 30 recipients exceeded the concentrations that were associated with protection in previous clinical studies. Furthermore, the median concentration of serum anti-toxin A IgG in the test group was 50-fold higher than the previous threshold. These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile-associated diarrhea and colitis.
authors.affiliation: Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Samer
authors.initials: S
authors.lastname: Aboudola
authors.forename: Karen L
authors.initials: KL
authors.lastname: Kotloff
authors.forename: Lorraine
authors.initials: L
authors.lastname: Kyne
authors.forename: Michel
authors.initials: M
authors.lastname: Warny
authors.forename: Eoin C
authors.initials: EC
authors.lastname: Kelly
authors.forename: Stavros
authors.initials: S
authors.lastname: Sougioultzis
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Giannasca
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Monath
authors.forename: Ciarán P
authors.initials: CP
authors.lastname: Kelly
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D016360:Clostridioides difficile / Q000276:immunology*; D003967:Diarrhea / Q000517:prevention & control; D004768:Enterotoxins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D014121:Toxoids / Q000276:immunology; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D004768:Enterotoxins; D007074:Immunoglobulin G; D014121:Toxoids; C041348:tcdA protein, Clostridium difficile