[Dose-response effect of a dentifrice formulation with low fluoride concentration - an in vitro study].
The utilization of dentifrices with low fluorine concentration, for children under 6 years of age, has been suggested to reduce the risks of dental fluorosis. However, in order to have anticariogenic potential, the dentifrice should form loosely-bound fluorine (CaF2) on dental enamel. Considering that the formation of CaF2 is a function inversely related to pH, dentifrices with pH 5.5, with 275, 550 and 1,100 ppm F (NaF/silica) were developed in order to assess dose-response effects. A comparison between those dentifrices, a placebo product and the Crest toothpaste (positive control - standard) was carried out. Furthermore, the bioavailability of dentifrices, in terms of formation of total fluorine (TF), CaF2, and fluorapatite (FA) on human dental enamel, was evaluated. An ion-specific electrode was utilized for the determination of the dosage of fluorine. The results revealed that the dentifrice with 550 ppm F was more effective than both the placebo and the dentifrice with 275 ppm, presenting no difference in relation to the positive control (p > 0.05). A dose-effect correlation was observed as to the CaF2 formed. In conclusion, the modified formulation with 550 ppm F can be considered as effective as the standard dentifrice with 1,100 ppm, and its utilization would be safer with regard to dental fluorosis.
Negri
Helena Maria Decico
HM
Faculdade de Odontologia de Araraquara, Brasil.
Cury
Jaime Aparecido
JA
D001031:Apatites / Q000032:analysis / Q000494:pharmacology; D018786:Bone Substitutes / Q000032:analysis / Q000494:pharmacology; D002675:Child, Preschool; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000032:analysis / Q000494:pharmacology; D005461:Fluorine / Q000032:analysis / Q000494:pharmacology*; D009050:Fluorosis, Dental / Q000517:prevention & control*; D006801:Humans; D008964:Molar, Third; D019228:Tooth Crown / Q000737:chemistry / Q000187:drug effects; D014100:Toothpastes / Q000737:chemistry / Q000494:pharmacology*
D001031:Apatites; D018786:Bone Substitutes; D014100:Toothpastes; D005461:Fluorine; C025105:fluorapatite; D005459:Fluorides