Considering nuclear compartmentalization in the light of nuclear dynamics.
Many proteins are concentrated in compartments within the nucleus. Chromatin is also compartmentalized at different nuclear sites. However, nuclear proteins have now been shown to be highly mobile. This review considers the formation and function of nuclear compartments in a situation in which proteins are rapidly moving through the nuclear volume.
Chubb
Jonathan R
JR
MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom.
Bickmore
Wendy A
WA
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D002843:Chromatin / Q000378:metabolism*; D004718:Saccharomycetales / Q000648:ultrastructure; D014158:Transcription, Genetic
D002843:Chromatin