title: [Study on the differentiation of K562 cell-line induced by Tanshinone II A].
abstract: OBJECTIVE
  To investigate the effect of Tanshinone II A on K562 cell-line and its possible mechanism.
  
  
  METHODS
  Cell culture, cytomorphology and cytometrics were used.
  
  
  RESULTS
  The proliferative inhibition of K562 cells induced by Tanshinone II A was dose-independent, and the degrees of erythroid differentiation induced by 30 nmol/L ACM and 0.5 microgram/ml Tanshinone II A were not statistically different (P > 0.05).
  
  
  CONCLUSIONS
  Tanshinone II A has an inhibitive effect on the proliferation of K562 cells and an inductive effect on the differentiation of erythrocyte series. The mechanisms may be related to the changes of cell cycle and gene expressions.
authors.affiliation: Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yang
authors.forename: Wentong
authors.initials: W
authors.lastname: Meng
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Jia
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
mesh_terms: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000473:pathology*; D010616:Phenanthrenes / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D016271:Proto-Oncogene Proteins c-myc; C021751:tanshinone