[Early recurrent meningioma with malignant transformation: case report].
It has been reported that the incidence of malignant transformation of meningioma is 10 to 38%. However, it is rare for a benign meningioma to recur with malignant transformation shortly after surgery. We reported a case of recurrent meningioma with malignant transformation 4 months after the initial surgery. A 64-year-old female was admitted for meningioma in the right parietal convexity on July 1, 1999. The tumor was totally resected on August 31st. There were no surgically nor histologically detected malignancies. The tumor was diagnosed as a psammomatous meningioma, but there was a co-exsisting transitional meningioma-like area. There were no postoperative neurological deficits, but, left hemiparesis and numbness on the left side of the body appeared around the end of December, and the patient was re-hospitalized on January 11, 2000. The CT scan and MRI showed that a cystic tumor had formed at the site of the previous tumor. Using Gd-DTPA, this new tumor showed ring enhancement. The tumor was extirpated again on February 3, 2000. It was histologically diagnosed as a malignant transformation of the meningioma. The Patient died of tumor recurrence on December 17, 2000. We speculated that the mechanism of recurrence as follows: Tumor cells with the possibility of becoming malignant, remained in the brain after the initial surgery. Postoperatively, these cells underwent malignant transformation and the tumor recurred.
Nakatsuka
Hiroki
H
Department of Neurological Surgery, Ehime University School of Medicine, Japan.
Ohue
Shiro
S
Ohta
Shinsuke
S
Nakagawa
Kou
K
Fukumoto
Shin-ya
SY
Kumon
Yoshiaki
Y
Ohnishi
Takanori
T
D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013997:Time Factors