title: Locally advanced breast cancer in the elderly: a major challenge requiring effective and appropriate treatment.
abstract: OBJECTIVE
  Breast cancer is the most common tumor in women. As the population above 65 years increases, breast cancer will be a more substantial problem for elderly patients. This work reports our experience in the management of stage III and IV locally advanced breast cancer.
  
  
  METHODS
  Nineteen patients over 65 years of age (mean, 70.3 years) with stage III and IV breast cancers, treated between 1990 and 2000, are considered. The management and outcome are evaluated.
  
  
  RESULTS
  Nine patients had stage IIIA breast cancer, 7 stage IIIB and 3 stage IV. Sixteen underwent Madden mastectomy and 3 simple mastectomy. Patients at stage IIIB and 1 patient at stage IV with T4 tumor received neo-adjuvant chemotherapy. There were no significant postoperative complications. Sixteen patients were given tamoxifen and 10 patients adjuvant chemotherapy. Patients were followed for a median of 36.7 months (range, 6-72 months). In 8 patients with stage IlIl disease, metastasis developed. Two patients had local recurrence of disease. Of the patients at stage IIIA, 6 were free from disease (one died from unrelated causes) and 3 had recurrent disease (2 died). Of the patients at stage IIIB, 2 are disease free and 5 had recurrent disease and died. Of the patients at stage IV, only one is alive.
  
  
  CONCLUSIONS
  Stage and individual characteristics of elderly women influence management. Patients should be managed adequately since most of them are fit enough to undergo treatment.
authors.affiliation: Chair of General Surgery I, University Polyclinic, Catania, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Brancato
authors.forename: Luigi
authors.initials: L
authors.lastname: Gandolfo
authors.forename: Antonio
authors.initials: A
authors.lastname: Privitera
authors.forename: Marcello
authors.initials: M
authors.lastname: Donati
authors.forename: Corrado
authors.initials: C
authors.lastname: Amodeo
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000379:methods; D009367:Neoplasm Staging; D016896:Treatment Outcome