Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss).
The lead (Pb) chelator, meso-2,3-dimercaptosuccinic acid (DMSA) may be effective in reversing some of the adverse effects of Pb exposure. Pb-induced behavioral deficits observed in fish are due to disruptions in the integrative functioning of the medulla, cerebellum, and optic tectum. Pb exposure increased serotonin (5-HT) content in all three brain regions without an effect on 5-hydroxy-3-indoleacetic acid (5-HIAA). Pb exposure followed by no Pb in the diet increased 5-HT and 5-HIAA content in all three brain regions. The replacement of dietary Pb with DMSA had no effect on 5-HT and increased 5-HIAA content. DMSA increased 5-HIAA content in all three brain regions and increased 5-HT content only the optic tectum. Treatment with DMSA may be more effective than removal of Pb from the diet in reversing Pb-induced alterations in 5-HT.
Rademacher
David J
DJ
Department of Psychology, University of Wisconsin-Milwaukee, 224 Garland Hall, 2441 East Hartford Avenue, Milwaukee, WI 53211, USA. drademac@mcw.edu
Steinpreis
Rhea E
RE
Weber
Daniel N
DN
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology*; D004032:Diet; D015386:Hazardous Substances / Q000633:toxicity*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism; D017686:Oncorhynchus mykiss; D012701:Serotonin / Q000378:metabolism*; D004113:Succimer / Q000494:pharmacology*; D013477:Superior Colliculi / Q000187:drug effects / Q000378:metabolism
D000931:Antidotes; D002614:Chelating Agents; D015386:Hazardous Substances; D007854:Lead; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004113:Succimer