Increased polymer length of oligopeptide-substituted polynorbornenes with LiCl.
The ring-opening metathesis polymerization (ROMP) reaction is extraordinarily useful for the preparation of a large variety of polymers. We report that the length (n = 25-50) of high-substituent-density oligopeptide polymers synthesized by ROMP is dramatically improved upon addition of LiCl to reduce polymer and oligopeptide aggregation. This methodology should significantly expand the variety of polymers that may be prepared by ROMP and be of general use with norbornyl oligopeptides of any sequence.
Roberts
Kenny S
KS
Department of Chemistry, State University of New York, Stony Brook, New York 11794-3400, USA.
Sampson
Nicole S
NS
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D018021:Lithium Chloride; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009636:Norbornanes / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D009636:Norbornanes; D009842:Oligopeptides; D011108:Polymers; D018021:Lithium Chloride