title: [Significance of screening by iodine staining of endoscopic examination in the area of high incidence of esophageal carcinoma].
abstract: OBJECTIVE
  In order to improve early detection and visualization of esophageal premalignant lesion and carcinoma, this study was designed to explore significance of the screening by iodine staining of endoscopic examination in the area of high incidence of esophageal carcinoma.
  
  
  METHODS
  Three screenings were completed through endoscopic examination for 3164 persons in high-risk population. Esophageal epithelium was stained with iodine in endoscopic examination. According to mucosal color and pathological result, esophageal carcinoma and premalignant lesion were confirmed.
  
  
  RESULTS
  After staining, the normal epithelium became brown and precancerous or malignant epithelium manifested yellow with sharp margin. (1) 100% early esophageal cancer was iodine staining positive, all lesions were grade I to grade II. The incidence rates of early esophageal carcinoma and advanced esophageal carcinoma were 1.60%-4.59% and 0.29%-1.09%, respectively. Early detection rate of esophageal carcinoma was all over 75%. (2) 95.6% severe dysplasia were staining positive; 91.3% lesion were grade I and grade II in staining. The incidence rate of severe dysplasia was 4.49%-7.68%. (3) 96.6% moderate dysplasia was positive in iodine staining, 73.3% lesion were grade II and grade III. (4) 92.3% mild dysplasia was positive in iodine staining; most of lesions were grade III. (5) 0.9% esophagitis and 0.4% normal esophageal mucosal were grade I and grade II in iodine staining, most of lesion were negative or grade III.
  
  
  CONCLUSIONS
  The results demonstrated that the screening with endoscopic staining examination could improve early detection of esophageal carcinoma and precancerous lesion. Iodine staining showed highly sensitivity and specificity for identifying these precancerous and early squamous cancer lesions; it may be helpful for diagnosis of early esophageal carcinoma and precancerous lesion.
authors.affiliation: Department of Endoscopy, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Beijing 100021, PR China. wangguiq@public.bta.net.cn
authors.forename: Gui-Qi
authors.initials: GQ
authors.lastname: Wang
authors.forename: Wen-Qiang
authors.initials: WQ
authors.lastname: Wei
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Hao
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Lin
authors.forename: Hong-Tu
authors.initials: HT
authors.lastname: Zhang
authors.forename: Yun-Tian
authors.initials: YT
authors.lastname: Sun
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Wang
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Dong
mesh_terms: D004724:Endoscopy / Q000379:methods; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D007455:Iodine; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D013194:Staining and Labeling / Q000379:methods*
chemical_list: D007455:Iodine