title: Peripheral retinal nonperfusion associated with chronic myeloid leukemia.
abstract: OBJECTIVE
  To report a case of peripheral retinal nonperfusion and chronic myeloid leukemia in a 23-year-old woman.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A complete ophthalmic and systemic evaluation was performed.
  
  
  RESULTS
  Ophthalmic examination revealed peripheral retinal nonperfusion with retinal neovascularization in both eyes. Fluorescein angiography of both eyes showed a marked midperipheral and peripheral avascular retina temporally with arteriovenous anastomosis and seafan neovascularizations. Blood work showed no abnormalities, although marked leucocytosis (up to 750 x 10(9)/l) and thrombocytosis (646 x 10(9)/l) were present in 1998 when the patient was diagnosed with leukemia. Following treatment, the patient has been in remission.
  
  
  CONCLUSIONS
  Peripheral retinal nonperfusion with retinal neovascularization may occur as a complication of chronic myeloid leukemia. In contrast to other studies describing this association, our patient had a bilateral peripheral retinal nonperfusion with seafan neovascularizations without relapse of the myeloid leukemia and without any of the other retinal signs associated with chronic myeloid leukemia, such as tortuosity of veins, intraretinal or preretinal hemorrhages, and cotton-wool exudates.
authors.affiliation: Department of Ophthalmology, University Medical Centre, Nijmegen, The Netherlands. s.nobacht@ohk.azn.nl
authors.forename: Siamak
authors.initials: S
authors.lastname: Nobacht
authors.forename: Kathleen F K
authors.initials: KF
authors.lastname: Vandoninck
authors.forename: August F
authors.initials: AF
authors.lastname: Deutman
authors.forename: B Jeroen
authors.initials: BJ
authors.lastname: Klevering
mesh_terms: D000328:Adult; D001164:Arteriovenous Fistula / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000503:physiopathology; D012039:Regional Blood Flow; D012164:Retinal Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D019572:Retinal Neoplasms / Q000150:complications* / Q000503:physiopathology; D015861:Retinal Neovascularization / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D012171:Retinal Vessels / Q000503:physiopathology*