Early expression of hypoxia-inducible factor 1alpha in the chicken embryo.
Hypoxia is known to regulate angiogenesis and tissue growth by the induction of the alpha subunit of the heterodimeric transcription factor, hypoxia-inducible factor 1. The expression pattern of HIF1alpha in both epithelial and mesenchymal structures of the chicken embryo through the first 7 days of development is reported here. HIF1alpha transcript is expressed diffusely throughout the neuroepithelium, limb, mesonephritic and cephalic mesenchyme, progressively becoming restricted to known proliferative zones of the central nervous system. Specific, strong expression is unexpectedly found in the endoderm of Sessel's pouch and in the ectoderm of both Rathke's pouch and the first branchial arch before the disappearance of the buccopharyngeal membrane.
Etchevers
Heather C
HC
Institut d'Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, 49 bis avenue de la Belle Gabrielle, 94736 Nogent-sur-Marne Cedex, France. etchever@infobiogen.fr
D000818:Animals; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D020869:Gene Expression Profiling; D051793:Hypoxia-Inducible Factor 1; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D051793:Hypoxia-Inducible Factor 1; D009687:Nuclear Proteins; D014157:Transcription Factors