Cytotoxic hydroazulene diterpenes from the brown alga Cystoseira myrica.
Cytotoxicity-guided fractionation of the alcohol extract of the brown alga, Cystoseira myrica, afforded four new cytotoxic hydroazulene diterpenes, dictyone acetate (2), dictyol F monoacetate (4), isodictytriol monoacetate (6), and cystoseirol monoacetate (8), together with two known cytotoxic hydroazulene diterpenes, pachydictyol A (1) and dictyone (3). The constitution of each isolated compound has been determined on the basis of spectroscopic and chemical evidence.
Ayyad
Seif-Eldin N
SE
Department of Chemistry, Faculty of Science, Mansoura University, New Damietta, Egypt. snayyad@mans.edu.eg
Abdel-Halim
Osama B
OB
Shier
W Thomas
WT
Hoye
Thomas R
TR
D016475:3T3 Cells; D000818:Animals; D002470:Cell Survival; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification
D003603:Cytotoxins; D004224:Diterpenes; D010936:Plant Extracts