title: The effect of root modification and biomodification on periodontal therapy.
abstract: Root surface biomodification has been used to treat periodontitis and gingival recession. The rationale for this procedure is that removing the smear layer from the root surfaces exposes collagen fibers, which leads to improved healing. Although animal studies have shown promising results, human studies have been disappointing. Some experts claim that the use of low-pH biomodification agents may cause necrotizing effects, and the use of neutral-pH agents does not. However, clinical investigations generally have failed to find any improvement in clinical parameters when using such agents.
authors.affiliation: Department of Periodontics, Forsyth Institute, Boston, Massachusetts, USA.
authors.forename: Moawia
authors.initials: M
authors.lastname: Kassab
authors.forename: Robert E
authors.initials: RE
authors.lastname: Cohen
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002448:Cell Adhesion; D002614:Chelating Agents / Q000627:therapeutic use; D019343:Citric Acid / Q000627:therapeutic use; D003094:Collagen / Q000648:ultrastructure; D012534:Dental Scaling / Q000295:instrumentation / Q000379:methods; D004492:Edetic Acid / Q000627:therapeutic use; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000502:physiology; D005889:Gingival Recession / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009336:Necrosis; D010510:Periodontal Diseases / Q000628:therapy*; D016745:Root Planing / Q000295:instrumentation / Q000379:methods; D016369:Smear Layer; D013752:Tetracycline / Q000627:therapeutic use; D014092:Tooth Root / Q000187:drug effects / Q000648:ultrastructure*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D004731:Endotoxins; D019343:Citric Acid; D003094:Collagen; D004492:Edetic Acid; D013752:Tetracycline