Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn.
A non-toxic dose of abrin, (1.25 microg/kg body wt) consecutively for five days in normal mice stimulated specific humoral responses. A noticeable increase was observed in total leucocyte count, lymphocytosis, weights of spleen and thymus, circulating antibody titre, antibody forming cells, bone marrow cellularity and alpha-esterase positive bone marrow cells. The results suggest that abrin can potentiate the humoral immune response of the host.
Ramnath
V
V
Department of Physiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680 651, India.
Kuttan
Girija
G
Kuttan
Ramadasan
R
D000036:Abrin / Q000494:pharmacology*; D029912:Abrus / Q000737:chemistry*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D004950:Esterases / Q000378:metabolism; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000139:chemically induced*; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects*; D012639:Seeds / Q000737:chemistry; D013154:Spleen / Q000378:metabolism; D013234:Stem Cells / Q000187:drug effects; D013950:Thymus Gland / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000036:Abrin; D004950:Esterases