title: Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults.
abstract: This randomized, double-blind, controlled trial evaluated the influence of low fat, low saturated fat food products that contained free tall oil-based phytosterols (TOP) and oat beta-glucan (from whole oats and bran concentrate) on serum lipid concentrations in adults with mild-to-moderate hypercholesterolemia. After a 5-wk National Cholesterol Education Program Step I diet lead-in period, 112 subjects incorporated one of two treatments into their diets for 6 wk: food products (cereal, snack bar and beverage) that provided 1.8 g TOP and 2.8 g beta-glucan/d and contained < or =3.0 g total fat and < or =1.0 g saturated fat (TOP/beta-glucan treatment) or similar control foods. The serum LDL cholesterol response from baseline to the end of study was significantly larger in the TOP/beta-glucan treated group than in the control group, in which there was no change (-3.7 vs. 0.4%; P = 0.013). Likewise, total cholesterol decreased in the TOP/beta-glucan treatment group and did not change significantly in the controls (-2.3 vs. 0.8%; P = 0.043). Serum HDL cholesterol and triglyceride responses did not differ between the groups. The results of this trial suggest that consumption of a group of low fat, TOP and beta-glucan- containing foods is a useful adjunct in the dietary management of hypercholesterolemia.
authors.affiliation: Chicago Center for Clinical Research, IL, USA. kmaki@protocare.com
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.forename: Fred
authors.initials: F
authors.lastname: Shinnick
authors.forename: Marlyn A
authors.initials: MA
authors.lastname: Seeley
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Veith
authors.forename: Laura C
authors.initials: LC
authors.lastname: Quinn
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Hallissey
authors.forename: Arlene
authors.initials: A
authors.lastname: Temer
authors.forename: Michael H
authors.initials: MH
authors.lastname: Davidson
mesh_terms: D000328:Adult; D000368:Aged; D018554:Avena / Q000737:chemistry; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D004032:Diet; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D005936:Glucans / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000008:administration & dosage* / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D004043:Dietary Fiber; D005936:Glucans; D010840:Phytosterols; D014280:Triglycerides; D002784:Cholesterol