ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation.
Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
Aiello
Robert J
RJ
Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Eastern Point Road, Groton, Conn 06340, USA. Robert_J_Aiello@groton.pfizer.com
Brees
Dominique
D
Francone
Omar L
OL
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D007246:Infertility / Q000235:genetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D018345:Mice, Knockout; D010641:Phenotype; D013329:Structure-Activity Relationship; D013631:Tangier Disease / Q000235:genetics / Q000378:metabolism
C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D001055:Apolipoproteins B; D008076:Cholesterol, HDL