DOK4 and DOK5: new Dok-related genes expressed in human T cells.
Dok proteins are adapter proteins involved in signal transduction. Several intracellular proteins expressed in lymphocytes meet the criteria of membrane-associated adapter proteins such as members of the Dok family. To understand the role and the formation of multiprotein networks involving Dok proteins in T lymphocytes, we search for potential additional members of this family. Here, we describe the two new human dok-related genes DOK4 and DOK5 and present data showing the expression of DOK4 and DOK5 genes in T cells. These genes are the orthologues of mouse Dok4 and Dok5 genes. Based on analysis of phylogenetic trees and exon/intron structure of Dok family members, DOK4 and DOK5 define a subfamily within dok genes distinct from DOK1, DOK2 and DOK3. So, Dok-4 and Dok-5 molecules constitute a new group of adapter proteins in T cells, requiring further functional analysis.
Favre
C
C
U11 INSERM, Institut de Cancérologie et d'Immunologie de Marseille, Université de la Méditerranée, Marseille, France.
Gérard
A
A
Clauzier
E
E
Pontarotti
P
P
Olive
D
D
Nunès
J A
JA
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D010750:Phosphoproteins; D010802:Phylogeny; D013601:T-Lymphocytes / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C486625:DOK4 protein, human; C432912:DOK5 protein, human; C499010:Dok5 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins