title: Effect of D-amino acids on some mitochondrial functions in rat liver.
abstract: We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (deltapsi) was decreased in the presence of 1 microM Ca(2+). The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.
authors.affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich. México.
authors.forename: J C
authors.initials: JC
authors.lastname: González-Hernández
authors.forename: L
authors.initials: L
authors.lastname: Aguilera-Aguirre
authors.forename: V
authors.initials: V
authors.lastname: Pérez-Vázquez
authors.forename: J
authors.initials: J
authors.lastname: Ramírez
authors.forename: M
authors.initials: M
authors.lastname: Clemente-Guerrero
authors.forename: C
authors.initials: C
authors.lastname: Cortés-Rojo
authors.forename: A
authors.initials: A
authors.lastname: Saavedra-Molina
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids