No evidence of fetal DNA persistence in maternal plasma after pregnancy.
Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular microchimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.
Smid
Maddalena
M
Department of Obstetrics and Gynecology, H. San Raffaele, Milano, Italy.
Galbiati
Silvia
S
Vassallo
Antonia
A
Gambini
Dania
D
Ferrari
Augusto
A
Viora
Elsa
E
Pagliano
Marco
M
Restagno
Gabriella
G
Ferrari
Maurizio
M
Cremonesi
Laura
L
D004247:DNA / Q000097:blood*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D024282:Genes, sry; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy
D004247:DNA