title: Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population.
abstract: Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only approximately 20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.
authors.affiliation: Department of Pathology, University of California, San Diego, California, USA. a.leigh-brown@ed.ac.uk a.leigh-brown@ed.ac.uk
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Leigh Brown
authors.forename: Simon D W
authors.initials: SD
authors.lastname: Frost
authors.forename: W Christopher
authors.initials: WC
authors.lastname: Mathews
authors.forename: Keith
authors.initials: K
authors.lastname: Dawson
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Hellmann
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daar
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Richman
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Little
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D009656:North America / Q000453:epidemiology; D012189:Retrospective Studies; D017211:Treatment Failure; D014505:Urban Population; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents