title: Taxol-based eluting stents from theory to human validation: clinical and intravascular ultrasound observations.
abstract: Treatment with antiproliferative drugs via coated stents appears to be a promising approach to both mechanically remodel target lesions and biologically reduce neointimal hyperplasia. Drug-eluting stents can maximize local drug effects and minimize the potential for systemic toxic effects. The purpose of this review is to describe the effects of a lipophilic microtubular inhibitor, paclitaxel, a strong antiproliferative agent under clinical investigation, and to define the vascular response to taxol-based eluting stents by intravascular ultrasound.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University Medical Center, California 94305, USA.
authors.forename: Shinjo
authors.initials: S
authors.lastname: Sonoda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Honda
authors.forename: Toru
authors.initials: T
authors.lastname: Kataoka
authors.forename: Heidi N
authors.initials: HN
authors.lastname: Bonneau
authors.forename: Krishnankutty
authors.initials: K
authors.lastname: Sudhir
authors.forename: Paul G
authors.initials: PG
authors.lastname: Yock
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fitzgerald
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D019917:Blood Vessel Prosthesis Implantation; D006348:Cardiac Surgical Procedures; D002986:Clinical Trials as Topic; D020099:Coated Materials, Biocompatible / Q000494:pharmacology* / Q000627:therapeutic use*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000517:prevention & control; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology* / Q000627:therapeutic use*; D015203:Reproducibility of Results; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D020533:Angiogenesis Inhibitors; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel