[Study on effects of scutellarin on scavenging reactive oxygen].
OBJECTIVE
To study the antioxidative effects and its mechanism of scutellarin.


METHODS
Scavenging effects of scutellarin on hydroxyl radical (OH.) produced from 0-phenathroline-ascorbic acid system, super oxide anion radical (O2-.) produced from xanthine-xanthine oxidase-luminol system and hydrogen peroxide was studied by a chemiluminescence assay.


RESULTS
Scutellarin has a significant effect on scavenging hydroxyl radicals, super oxide anion radicals, hydrogen peroxide, their IC50 are 66 micrograms/ml, 1.3 micrograms/ml and 1.6 micrograms/ml respectively.


CONCLUSIONS
Scutellarin is an efficiency antioxidant.
Liu
Hong
H
Institute of Pharmacy, Huazhong University of Science & Technology, Wuhan 430074.
Yang
Xiangliang
X
Zhou
Linzhu
L
Xu
Huibi
H
D047310:Apigenin; D019659:Asteraceae / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005965:Glucuronates; D006861:Hydrogen Peroxide / Q000032:analysis; D017665:Hydroxyl Radical / Q000032:analysis; D008163:Luminescent Measurements; D010946:Plants, Medicinal / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000032:analysis*; D013481:Superoxides / Q000032:analysis
D005419:Flavonoids; D016166:Free Radical Scavengers; D005965:Glucuronates; D017382:Reactive Oxygen Species; D013481:Superoxides; C484876:scutellarin; D017665:Hydroxyl Radical; D047310:Apigenin; D006861:Hydrogen Peroxide; C458179:scutellarein