title: Nonmyeloablative preparative regimens for allogeneic hematopoietic transplantation. Biology and current indications.
abstract: High-dose myeloablative therapy with allogeneic hematopoietic transplantation is an effective treatment for hematologic malignancies, but this approach is associated with a high risk of complications. The use of relatively nontoxic, nonmyeloablative, or reduced-intensity preparative regimens still allows engraftment and the generation of graft-vs-malignancy effects, is potentially curative for susceptible malignancies, and reduces the risk of treatment-related morbidity. Two general strategies along these lines have emerged, based on the use of (1) immunosuppressive chemotherapeutic drugs, usually a purine analog in combination with an alkylating agent, and (2) low-dose total body irradiation, alone or in combination with fludarabine (Fludara).
authors.affiliation: Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. rchampli@mdacc.tmc.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Champlin
authors.forename: Issa
authors.initials: I
authors.lastname: Khouri
authors.forename: Paolo
authors.initials: P
authors.lastname: Anderlini
authors.forename: Marcos
authors.initials: M
authors.lastname: De Lima
authors.forename: Chitra
authors.initials: C
authors.lastname: Hosing
authors.forename: John
authors.initials: J
authors.lastname: McMannis
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Molldrem
authors.forename: Naoto
authors.initials: N
authors.lastname: Ueno
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D020350:Graft vs Tumor Effect; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents