title: Differential responses to acoustic damage and furosemide in auditory brainstem and otoacoustic emission measures.
abstract: Characteristics of distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs) were measured in Mongolian gerbil before and after the introduction of two different auditory dysfunctions: (1) acoustic damage with a high-intensity tone, or (2) furosemide intoxication. The goal was to find emission parameters and measures that best differentiated between the two dysfunctions, e.g., at a given ABR threshold elevation. Emission input-output or "growth" functions were used (frequencies f1 and f2, f2/f1 = 1.21) with equal levels, L1 = L2, and unequal levels, with L1 = L2 + 20 dB. The best parametric choice was found to be unequal stimulus levels, and the best measure was found to be the change in the emission threshold level, delta x. The emission threshold was defined as the stimulus level required to reach a criterion emission amplitude, in this case -10 dB SPL. (The next best measure was the change in emission amplitude at high stimulus levels, specifically that measured at L1 x L2 = 90 x 70 dB SPL.) For an ABR threshold shift of 20 dB or more, there was essentially no overlap in the emission threshold measures for the two conditions, sound damage or furosemide. The dividing line between the two distributions increased slowly with the change in ABR threshold, delta ABR, and was given by delta x(t) = 0.6 delta ABR + 8 dB. For a given delta ABR, if the shift in emission threshold was more than the calculated dividing line value, delta x(t), the auditory dysfunction was due to acoustic damage, if less, it was due to furosemide.
authors.affiliation: V. M. Bloedel Hearing Research Center, Department of Otolaryngology, Head & Neck Surgery, University of Washington, Seattle, Washington 98195, USA. dmmills@u.washington.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Mills
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005665:Furosemide / Q000633:toxicity*; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects / Q000503:physiopathology; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000503:physiopathology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects* / Q000502:physiology; D013018:Sound Spectrography
chemical_list: D005665:Furosemide