title: Clinical evaluation of the Elecsys CA 15-3 test in breast cancer patients.
abstract: The aim of the present study was to evaluate the clinical performance of the CA 15-3 assay on Elecsys systems in an international multicenter study (11 centers). A total of 1326 single samples (272 apparently healthy individuals, 34 pregnant women, 308 benign diseases, 273 cancers other than breast, 439 breast cancer) and 538 serial samples of 98 breast cancer patients during follow-up were analyzed. 95% of values in healthy individuals were below 25 kU/L, and 88% in benign breast diseases, respectively. In malignant breast disease at primary diagnosis the value distribution of Elecsys CA 15-3, sensitivity at 95% specificity, as well as the areas under the curve in ROC analysis were clearly correlated to tumor stages: UICC I to IV 88 to 25% of values < 25 kU/L, sensitivity 7 to 78%, areas under the curve 0.53 to 0.94. During follow-up, sensitivity/specificity for detection of recurrences were 90%/71%. In metastatic disease clinical progression/response to therapy were indicated in 91%/78% of patients at a specificity of 92%/78%. The findings indicate that the Elecsys CA 15-3 assay is very suitable in routine work for detection of recurrences as well as for therapy control in metastatic breast cancer.
authors.affiliation: Klinikum der Universität München -Grosshadern-, Institut für Klinische Chemie, Munich, Germany. stieber@klch.med.uni-muenchen.de
authors.forename: Petra
authors.initials: P
authors.lastname: Stieber
authors.forename: Rafael
authors.initials: R
authors.lastname: Molina
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Chan
authors.forename: Herbert A
authors.initials: HA
authors.lastname: Fritsche
authors.forename: Ralf
authors.initials: R
authors.lastname: Beyrau
authors.forename: Jean M G
authors.initials: JM
authors.lastname: Bonfrer
authors.forename: Xavier
authors.initials: X
authors.lastname: Filella
authors.forename: Terrie G
authors.initials: TG
authors.lastname: Gornet
authors.forename: Torsten
authors.initials: T
authors.lastname: Hoff
authors.forename: Wolfram
authors.initials: W
authors.lastname: Jäger
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: van Kamp
authors.forename: Dorothea
authors.initials: D
authors.lastname: Nagel
authors.forename: Klaus
authors.initials: K
authors.lastname: Peisker
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Sokoll
authors.forename: Frédéric
authors.initials: F
authors.lastname: Troalen
authors.forename: Michael
authors.initials: M
authors.lastname: Untch
authors.forename: Ingrid
authors.initials: I
authors.lastname: Domke
mesh_terms: D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood; D012016:Reference Values; D012189:Retrospective Studies; D014481:United States
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018396:Mucin-1