title: [Polycystic ovaraian syndrome and hyperinsulinemia].
abstract: OBJECTIVE
  To identify the relationship between polycystic ovarian syndrome and hyperinsulinemia.
  
  
  METHODS
  Age, body height, body weight, serum estradiol, progesterone, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), triiodothyronine (T3), tetraiodothyronine (T4), insulin, oral glucose tolerance test (OGTT), and cortisol were measured in 28 patients with polycystic ovarian syndrome (PCOS).
  
  
  RESULTS
  Sxiteen patients (57.1% of total) had hyperinsulinemia. Among them one patient was found diabetic. No difference was noted in age, height, body weight, body mass index, serum estradiol, progesterone, testosterone, FSH, LH, PRL, T3, T4, cortisol, and glucose of OGTT between hyperinsulinemia and non-hyperinsulinemia patients. However the LH/FSH ratio (2.4 +/- 1.5) in hyperinsulinemia patients was significantly higher than 1.2 +/- 0.6 in non-hyperinsulinemia patients (P = 0.0125). In addition, the results showed that the fasting serum insulin, insulin after OGTT, the insulin/glucose ratio at 30, 120 minutes, 180 minutes, the area under curve of and the insulin, insulin resistant index (IRI) were higher in hyperinsulinemia pateints than in non-hyperinsulinemia patients respectively. Furthermore, the fasting insulin level, insulin/glucose ratio were found to be negatively related to insulin sensitivity index and positively related with beta-cell functioning index.
  
  
  CONCLUSIONS
  Hyperinsulinemia and insulin resistance accompany with some of the PCOS patients in China. Further investigations will be necessary to clarify the relevant mechanisms.
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041, China.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Yue
authors.forename: S
authors.initials: S
authors.lastname: Tan
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Qiu
authors.forename: Y
authors.initials: Y
authors.lastname: Kong
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: R
authors.initials: R
authors.lastname: Hu
authors.forename: L
authors.initials: L
authors.lastname: Deng
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000150:complications*