Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement.
Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.
Kohno
S
S
Department of Orthodontics, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Kaku
M
M
Tsutsui
K
K
Motokawa
M
M
Ohtani
J
J
Tenjo
K
K
Tohma
Y
Y
Tokimasa
C
C
Fujita
T
T
Kawata
T
T
Tanne
K
K
D000704:Analysis of Variance; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000235:genetics* / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000494:pharmacology / Q000502:physiology*; D008222:Lymphokines / Q000096:biosynthesis / Q000235:genetics* / Q000494:pharmacology / Q000502:physiology*; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical; D014087:Tooth Movement Techniques; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016173:Macrophage Colony-Stimulating Factor