The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).
The in vitro susceptibility of 20 medical isolates of Scedosporium prolificans to ajoene, allitridium and raw garlic extract derived from cloves of garlic (Allium sativum) was tested using the NCCLS reference method (with minor modifications) for broth microdilution. The results demonstrate that both garlic derivatives and raw garlic extract appear to have in vitro activity against S. prolificans.
Davis
Stephen R
SR
Mycology Unit, Women's and Children's Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia. sdavis@esc.net.au
Perrie
Rosemary
R
Apitz-Castro
Rafael
R
D000498:Allyl Compounds / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004220:Disulfides / Q000494:pharmacology*; D005737:Garlic; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018514:Plant Structures; D021681:Scedosporium / Q000187:drug effects* / Q000302:isolation & purification; D013440:Sulfides / Q000494:pharmacology*; D013454:Sulfoxides
D000498:Allyl Compounds; D000935:Antifungal Agents; D004220:Disulfides; D010936:Plant Extracts; D013440:Sulfides; D013454:Sulfoxides; C042577:diallyl trisulfide; C048980:ajoene