Are activation markers (CD25, CD38 and CD103) predictive of sensitivity to purine analogues in patients with T-cell prolymphocytic leukemia and other lymphoproliferative disorders?
T-cell prolymphocytic leukemia (T-PLL) is a rare lymphoproliferative disorder with distinctive clinical and laboratory features. It is often resistant to conventional chemotherapy, but complete or partial responses have been documented with the use of purine analogues. We report on two cases of T-PLL with a slightly different immunophenotype but a remarkably different response to pentostatin. We discuss the possible therapeutic implications of this finding and establish a comparison between immunophenotype and sensitivity to purine analogues in patients with T-PLL and other chronic lymphoproliferative disorders.
Delgado
Julio
J
Department of Hematology, Hospital Universitario La Paz, Planta 6a Diagonal, Paseo Castellana 261, 28046 Madrid, Spain. jdelgon@terra.es
Bustos
Jesus G
JG
Jimenez
Ma Carmen
MC
Quevedo
Evaristo
E
Hernandez-Navarro
Fernando
F
D036541:ADP-ribosyl Cyclase / Q000032:analysis; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD / Q000032:analysis* / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D039001:Integrin alpha Chains / Q000032:analysis; D015463:Leukemia, Prolymphocytic / Q000188:drug therapy* / Q000473:pathology; D015458:Leukemia, T-Cell / Q000188:drug therapy* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D011237:Predictive Value of Tests; D011687:Purines / Q000494:pharmacology / Q000627:therapeutic use*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012074:Remission Induction / Q000379:methods
D015703:Antigens, CD; D015415:Biomarkers; D039001:Integrin alpha Chains; D008562:Membrane Glycoproteins; D011687:Purines; D015375:Receptors, Interleukin-2; C091367:alpha E integrins; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1