DNA replication: telling time with microarrays.
A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?
McCune
Heather J
HJ
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Donaldson
Anne D
AD
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013997:Time Factors; D014158:Transcription, Genetic / Q000235:genetics