Ecological and immunopathological implications of oral bacteria in Helicobacter pylori-infected disease.
Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C. rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.
Okuda
Katsuji
K
Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba City, Chiba, Japan. kokuda@tdc.ac.jp
Kimizuka
Ryuta
R
Katakura
Akira
A
Nakagawa
Taneaki
T
Ishihara
Kazuyuki
K
D000898:Antibiosis / Q000502:physiology; D000942:Antigens, Bacterial / Q000276:immunology; D018988:Bacterial Translocation / Q000502:physiology; D002167:Campylobacter / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D004463:Ecology; D005756:Gastritis / Q000382:microbiology; D006360:Heat-Shock Proteins / Q000276:immunology; D016481:Helicobacter Infections / Q000276:immunology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009059:Mouth Diseases / Q000382:microbiology; D010437:Peptic Ulcer / Q000382:microbiology; D010510:Periodontal Diseases / Q000276:immunology / Q000382:microbiology
D000942:Antigens, Bacterial; D006360:Heat-Shock Proteins