Study of phagocytosis of senescent erythrocytes in young and elderly individuals.
There is a decrease in the percentage contribution of a heavy density fraction of red blood cells to whole blood with increasing age. The aim of this study was to investigate in the young and elderly the interaction between monocytes and different erythrocyte suspensions: senescent red blood cells, erythrocytes stored with or without serum, and desialylated red blood cells. The results obtained with senescent red blood cells and erythrocytes stored with serum show the involvement of autologous IgG in the selective removal of erythrocytes. These values were higher in elderly individuals, indicating that this process increases with age. Our observation suggest that desialylation is not involved in the increased removal of erythrocytes observed in elderly individuals.
Biondi
C
C
Department of Clinical Biochemistry, School of Biochemical Sciences, Rosario National University, Suipacha 531, 2000 Rosario, Argentina. cbiondi@fbioyf.unr.edu.ar
Cotorruelo
C
C
Garcia Borrás
S
S
Rocca
L
L
Ensinck
A
A
Marini
A
A
Racca
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D001793:Blood Preservation; D016922:Cellular Senescence; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*