title: Antifungal diterpenes from Hypoestes serpens (Acanthaceae).
abstract: Two new diterpenes, fusicoserpenol A and dolabeserpenoic acid A, with antifungal activity, were isolated from leaves of Hypoestes serpens (Acanthaceae). Their structures were elucidated by means of spectrometric methods including 1D and 2D NMR experiments and MS analysis. X-ray crystallographic analysis confirmed the structure of fusicoserpenol A and established the relative configuration.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: Lalao
authors.initials: L
authors.lastname: Rasoamiaranjanahary
authors.forename: Andrew
authors.initials: A
authors.lastname: Marston
authors.forename: David
authors.initials: D
authors.lastname: Guilet
authors.forename: Kurt
authors.initials: K
authors.lastname: Schenk
authors.forename: Fanantenanirainy
authors.initials: F
authors.lastname: Randimbivololona
authors.forename: Kurt
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D002963:Cladosporium / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; C473302:dolabeserpenoic acid A; C473303:fusicoserpenol A