title: Major vault protein/lung resistance-related protein (MVP/LRP) expression in nervous system tumors.
abstract: Lung resistance-related protein (LRP) was identified as the major vault protein (MVP), the main component of multimeric vault particles. It functions as a transport-associated protein that can be associated with multidrug resistance. In previous studies, expression of MVP/LRP has been documented in tumors of various types. In general, good correlations have been reported for expression of MVP/LRP and decreased sensitivity to chemotherapy and poor prognosis. MVP/LRP expression has been documented in glioblastomas, but its expression in nervous system tumors in general has not been well characterized. Immunohistochemistry using anti-human MVP/LRP antibody (LRP-56) was performed on formalin-fixed, paraffin-embedded archival tissue from 69 primary central nervous system tumors. Expression of MVP/LRP was observed in 81.2% (56/69) of primary nervous system tumors, including astrocytomas (11/13), oligodendrogliomas (1/2), oligoastrocytomas (5/5), ependymoma (1/1), meningiomas (35/45), schwannomas (2/2), and neurofibroma (1/1). Various degrees and distributions of immunoreactivity to MVP/ LRP were observed. Neither the presence nor the degree of immunoreactivity to MVP/LRP showed any correlation with either tumor grade or the presence of brain invasion.
authors.affiliation: Molecular Neurosurgery Laboratory, Department of Neurosurgery, PO Box 800212, University of Virginia, Charlottesville, VA 22908, USA. ts5k@virginia.edu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sasaki
authors.forename: Gerald R
authors.initials: GR
authors.lastname: Hankins
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Helm
mesh_terms: D000818:Animals; D005557:Formaldehyde; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D009423:Nervous System Neoplasms / Q000378:metabolism*; D011817:Rabbits / Q000276:immunology; D016707:Tissue Fixation; D020394:Vault Ribonucleoprotein Particles / Q000096:biosynthesis* / Q000235:genetics; D000099187:Major Vault Protein
chemical_list: D005557:Formaldehyde; D007074:Immunoglobulin G; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein