Fructose diet and VEGF-induced plasma extravasation in hamster cheek pouch.
OBJECTIVE
To determine in the hamster cheek pouch whether or not the changes in plasma extravasation induced by vascular endothelial growth factor (VEGF) could be affected by fructose diet.


METHODS
Hamsters were subjected to control drinking water or to water containing fructose (10 %) for 18 weeks.


RESULTS
The fructose diet induced a small but significant increase in glycemia (0.80+/-0.11 and 1.09+/-0.15, n=8 and 9 for control and fructose- treated animals, respectively, P<0.05). Bradykinin-induced plasma extravasation was not affected by the fructose diet while the effects of VEGF were markedly increased (maximal number of leakage sites: 76+/-20 and 126+/-55, n = 8 and 9 for control and fructose-treated animals, respectively, P<0.01).


CONCLUSIONS
Even moderate changes in glycemic levels can produce profound alteration in the VEGF response.
Félétou
Michel
M
Département Diabète et Maladies Métaboliques Institut de Recherches Servier, 92150 Suresnes, France. michel.feletou@fr.ntgrs.com
Boulanger
Michelle
M
Staczek
Joanna
J
Broux
Olivier
O
Duhault
Jacques
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001920:Bradykinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002610:Cheek / Q000098:blood supply*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005632:Fructose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D042461:Vascular Endothelial Growth Factor A; D005632:Fructose; D001920:Bradykinin