title: [NSIP group III treated with the first cadaveric single lung transplantation in Japan].
abstract: A 43-year-old woman developed dyspnea on effort in January 1996. She was treated with various antibiotics but developed dyspnea and pretibial edema. She was referred to our hospital and admitted on February 20, 1996. On the basis of the clinical course and radiological findings, she was diagnosed as having idiopathic pulmonary fibrosis with right-side heart failure. After high-dose steroid therapy (methylprednisolone, 1,000 mg/day for 3 days) and the administration of a diuretic, oral prednisolone therapy was initiated. Her condition gradually recovered. To obtain a definite diagnosis, an open lung biopsy was recommended but the patient refused the procedure. She was discharged from the hospital and placed on home oxygen therapy. After her informed consent was obtained, she became a candidate recipient for the nationwide Central Lung Transplant Evaluation Committee on August 7, 1998. Her name was then listed in the Japan Organ Transplant Network. The patient was admitted to our hospital in October 1998 because of respiratory failure. She underwent left lung transplantation at Osaka University Hospital on March 29, 2000. After the lung transplantation, she was discharged and is presently doing well without the need for supplementary oxygen. A differential diagnosis of the removed lung as nonspecific interstitial pneumonia (NSIP) group III or UIP was required. We finally diagnosed NSIP group III because of the temporal uniformity and diffuse distribution of the fibrosis. In this report, we also describe the background of the clinical diagnosis, the indications for lung transplantation and the clinical course before and after transplantation.
authors.affiliation: Second Department of Internal Medicine, NTT West Osaka Hospital, Tennoji-ku, Osaka, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Masaki
authors.forename: Hitomaru
authors.initials: H
authors.lastname: Masutani
authors.forename: Makiko
authors.initials: M
authors.lastname: Inaba
authors.forename: Masakazu
authors.initials: M
authors.lastname: Aitani
authors.forename: Keiji
authors.initials: K
authors.lastname: Maeda
authors.forename: Taro
authors.initials: T
authors.lastname: Kuritani
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Igarashi
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Masato
authors.initials: M
authors.lastname: Minami
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Hikaru
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D002102:Cadaver; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000601:surgery*; D016040:Lung Transplantation