title: Antimicrobial activity of antibiotic-soaked, Resist-coated Bioflex.
abstract: This study investigates whether a hydrophilic coating (Resist), designed to inhibit bacterial adherence, applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of antibiotic-soaked Bioflex (penile prosthetic substrate material) discs with and without Resist was examined by measuring the zone of inhibition following in vivo exposure in four groups of rabbits: 1, 2, 3 and 5 days' duration of disc implantation. Coated and uncoated discs were soaked in an aqueous solution of gentamicin and bacitracin. The implanted antibiotic-soaked discs were extracted, and the zone of inhibition against four microorganisms in vitro demonstrated that the Resist coating was especially effective against Staphylococcus epidermidis, and statistically significant improvements were observed for the coated over the uncoated substrate up to 3 days following implantation. This effect, and the anti-adherence properties of Resist, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection.
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA. whellst@tulane.edu
authors.forename: W J G
authors.initials: WJ
authors.lastname: Hellstrom
authors.forename: J S
authors.initials: JS
authors.lastname: Hyun
authors.forename: L
authors.initials: L
authors.lastname: Human
authors.forename: J A
authors.initials: JA
authors.lastname: Sanabria
authors.forename: T J
authors.initials: TJ
authors.lastname: Bivalacqua
authors.forename: S
authors.initials: S
authors.lastname: Leungwattanakij
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D007172:Erectile Dysfunction / Q000601:surgery*; D008297:Male; D015917:Penile Prosthesis / Q000382:microbiology*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D013212:Staphylococcus epidermidis; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000517:prevention & control