[Leptin levels during estrogenization phases in pubertal girls].
OBJECTIVE
We searched for associations between leptin levels, basic body composition, primary, secondary and tertiary sex features during pre-menarche without signs of estrogenization, estrogenic crisis and full estrogenization.


METHODS
The study group consisted of 45 healthy girls over the age of 8 years. Height, body mass, BMI, basic body composition and plasma concentration of leptin were determined every three months. In addition, ultrasound of the ovaries, uterus and breasts was done.


RESULTS
The highest levels of leptin were observed in girls without signs of estrogenization. The ratio of leptin/fat (ng/ml/kg) was higher in pubertal girls, particularly those without signs of estrogenization, than in adult women.


CONCLUSIONS
The estrogenic crisis was accompanied by a reduction in body mass, followed by the pubertal acceleration of growth and increase in fatty, lean and total body mass. The correspondence of tertiary sex features with pre-menarche, estrogenic crisis and full estrogenization phases did not exceed 55%. Enlargement of the uterine body was followed by a dynamic growth of ovaries. Individual variation in ovarian size was significant. Changes in leptin levels occurring during estrogenization point to the importance of this protein in metabolic signaling.
Błogowska
Anna
A
Katedry i Kliniki Ginekologii Operacyjnej i Onkologii Ginekologicznej Dorosłych i Dziewczat PAM.
Rzepka-Górska
Izabella
I
D000293:Adolescent; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D001940:Breast / Q000254:growth & development; D002648:Child; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D010053:Ovary / Q000000981:diagnostic imaging / Q000254:growth & development; D011627:Puberty / Q000097:blood*; D012727:Sex Characteristics; D012741:Sexual Maturation / Q000502:physiology*; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging / Q000254:growth & development
D004967:Estrogens; D020738:Leptin