Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters.
Sakurai
Nobuko
N
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.
Kozuka
Mutsuo
M
Tokuda
Harukuni
H
Nobukuni
Yoshitaka
Y
Takayasu
Junko
J
Nishino
Hoyoku
H
Kusano
Akiko
A
Kusano
Genjiro
G
Nagai
Masahiro
M
Sakurai
Yojiro
Y
Lee
Kuo Hsiung
KH
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens; D002470:Cell Survival / Q000187:drug effects; D031885:Cimicifuga / Q000737:chemistry; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
C478830:(23R,24S)-16,23-16,24-diepoxy-9,19-cyclolanostan-3beta,15alpha,25-triol; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D007810:Lanosterol; D015127:9,10-Dimethyl-1,2-benzanthracene