title: A summary of results of the Dietary Intervention Study in Children (DISC): lessons learned.
abstract: Prevention of cardiovascular disease must begin in childhood, preferably before risk factors develop. Elevated low-density lipoprotein cholesterol levels in children are likely to track over time and become high-risk levels in adults. The Dietary Intervention Study in Children (DISC) was a multicenter, collaborative randomized trial in pre-adolescent children designed to test the efficacy and safety of a dietary intervention to lower saturated fat and cholesterol intake among growing children with elevated low-density lipoprotein cholesterol. Numerous DISC results, which include findings on lipids-lipoproteins, genetics, and nutrient adequacy, as well as descriptions of the behavioral intervention strategies, have been reported. A summary of practical findings and their potential clinical applications have not previously been published. Highlights of key lessons learned from DISC and translational applications of potential interest to nurses and other health care providers are presented.
authors.affiliation: Department of Preventive Medicine, Northwestern University Medical School, 680 North Lake Shore Drive, #1102, Chicago, IL 60611, USA. LVanhorn@Northwestern.edu
authors.forename: Linda
authors.initials: L
authors.lastname: Van Horn
authors.forename: Eva
authors.initials: E
authors.lastname: Obarzanek
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Barton
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Stevens
authors.forename: Peter O
authors.initials: PO
authors.lastname: Kwiterovich
authors.forename: Norman L
authors.initials: NL
authors.lastname: Lasser
authors.forename: Alan M
authors.initials: AM
authors.lastname: Robson
authors.forename: Frank A
authors.initials: FA
authors.lastname: Franklin
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lauer
authors.forename: Sue Y S
authors.initials: SY
authors.lastname: Kimm
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Dorgan
authors.forename: Merwyn R
authors.initials: MR
authors.lastname: Greenlick
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism*; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007858:Learning; D008297:Male; D009752:Nutritional Status / Q000502:physiology; D011237:Predictive Value of Tests; D011581:Psychological Tests; D012741:Sexual Maturation / Q000502:physiology; D012959:Socioeconomic Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D014810:Vitamin E / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D014810:Vitamin E; D005293:Ferritins; D015032:Zinc