New roles for old proteins in adult CNS axonal regeneration.
The past year has yielded many insights and a few surprises in the field of axonal regeneration. The identification of oligodendrocyte-myelin glycoprotein as an inhibitor of axonal growth, and the discovery that the three major myelin-associated inhibitors of CNS regeneration share the same functional receptor, has launched a new wave of studies that aim to identify the signaling components of these inhibitory pathways. These findings also offer new avenues of research directed toward blocking possible therapeutic targets that inhibit regeneration and toward encouraging axonal regeneration in the CNS after injury.
Spencer
Timothy
T
Department of Biological Sciences, Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Domeniconi
Marco
M
Cao
Zixuan
Z
Filbin
Marie T
MT
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D002490:Central Nervous System / Q000254:growth & development / Q000293:injuries* / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism / Q000503:physiopathology; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009185:Myelin Proteins / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D009185:Myelin Proteins; D011956:Receptors, Cell Surface