title: [Clinical and epidemiological analysis of patients with botulism hospitalized at the Department of Infectious Disease, Medical University of Lublin in 1990-2000].
abstract: In the paper we presented results of clinical and epidemiological analysis of 32 patients with botulism hospitalized at the Department of Infectious Diseases, Medical University of Lublin in 1990-2000. In the studied group, the relationships between botulism incidence and sex and place of residence were not significant. The incubation period ranged from 7 hours to 5 days (average 36 hrs). The clinical manifestations of botulism were typical in all cases. In one female patient the course of disease was complicated. She developed right-sided bronchopneumonia and left-sided purulent parotitis. The type B botulinum toxin occurred more frequently than the other types and the cases without serological confirmation (Chi 2 = 6.125 p = 0.01). It was found in serum of 23 patients (in 2 cases together with the type A toxin). The type E toxin was found in serum of one patient. The presence of toxin in serum was not detected in 8 patients. In all patients trivalent (types A, B and E) equine antitoxin was administered. The dose ranged from 50 to 150 cm3. Symptomatic treatment was given in all cases. Nobody required mechanical ventilation. The duration of hospitalization ranged from 5 to 28 days (average 16.6 days). A few patients complained of long-lasting blurred vision or dry mouth.
authors.affiliation: Katedra i Klinika Chorób Zakaźnych Akademii Medycznej w Lublinie.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Bielec
authors.forename: Grazyna
authors.initials: G
authors.lastname: Semczuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Lis
authors.forename: Joanna
authors.initials: J
authors.lastname: Firych
authors.forename: Romana
authors.initials: R
authors.lastname: Modrzewska
authors.forename: Rafał
authors.initials: R
authors.lastname: Janowski
mesh_terms: D000328:Adult; D000368:Aged; D001904:Botulinum Antitoxin / Q000008:administration & dosage; D001905:Botulinum Toxins / Q000097:blood*; D001906:Botulism / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001904:Botulinum Antitoxin; D001905:Botulinum Toxins