title: Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity.
abstract: Cholesteryl ester transfer protein (CETP) is one of the key proteins in reverse cholesterol transport (RCT). The role of CETP in atherosclerosis remains controversial. In this study we investigated the associations between polymorphisms of CETP (mutations in intron 14 and exon 15, and Taq1B), hepatic lipase (C-514T), lipoprotein lipase ( PvuII and HindIII), and ATP-binding cassette transporter 1 (R219K) loci and longevity in 256 centenarians and 190 healthy younger controls. Although heterozygous CETP deficiency and the B2 allele of the Taq1B polymorphism was consistently associated with higher HDL-C concentrations both in centenarians and controls, the allelic frequencies of those polymorphisms did not differ between the two groups. The allelic frequencies of other gene polymorphisms in RCT were not different between the two groups. Centenarians with lipoprotein lipase P(-/-) genotype had significantly higher HDL-C concentration than those with P(-/+) or with P(+/+), in contrast, there was no such a relationship among controls. In stepwise multiple regression analysis, serum albumin, CETP deficiency and lipoprotein lipase PvuII genotype were independently associated with HDL-C in centenarians. Sex, CETP deficiency, and the Taq1B genotype were also independently associated with HDL-C; however, lipoprotein lipase PvuII genotype had no significant effect on their HDL-C in controls. In conclusion, we observed that CETP deficiency and other gene polymorphisms in RCT have no impact on longevity for Japanese centenarians.
authors.affiliation: Department of Geriatric Medicine, Keio University School of Medicine, 35, Shinanomachi, Shinjyuku-ku, P.O. Box 160-8582, Tokyo, Japan. yasumich@tka.att.ne.jp
authors.forename: Yasymichi
authors.initials: Y
authors.lastname: Arai
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Hirose
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamura
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Ken-Ichirou
authors.initials: K
authors.lastname: Shimizu
authors.forename: Michiyo
authors.initials: M
authors.lastname: Takayama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ebihara
authors.forename: Satoki
authors.initials: S
authors.lastname: Homma
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Gondo
authors.forename: Yukie
authors.initials: Y
authors.lastname: Masui
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inagaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002352:Carrier Proteins / Q000378:metabolism*; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008136:Longevity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012044:Regression Analysis
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008071:Lipoprotein Lipase