Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3.
OBJECTIVE
Wolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.


METHODS
Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.


RESULTS
Wolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5.


CONCLUSIONS
The gene of Wolff-Parkinson-White syndrome is located at 7q3.
Liu
Wenling
W
Cardiology Division, People's Hospital, Beijing University, Beijing 100044, China.
Liu
Guoshu
G
Hu
Dayi
D
Qi
Yu
Y
Shan
Zhaoliang
Z
Yang
Dayan
D
Liu
Deqiang
D
Wang
Yumei
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D020080:Tandem Repeat Sequences; D014927:Wolff-Parkinson-White Syndrome / Q000235:genetics*
D005819:Genetic Markers