Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle.
Macromolecular transport between the cytoplasm and the nucleus occurs through the nuclear pore complex (NPC) and is mediated by multiple families of soluble transport factors. All these transport factors share the ability to translocate across the NPC through specific interactions with components of the nuclear pore. This review highlights advances in our understanding of the structure and function of the NPC and the shuttling transport receptors involved in nuclear transport. It discusses recently proposed models for the translocation of receptor-cargo complexes through the NPC channel and reviews how the small GTPase Ran functions as a positional marker of the genome to regulate multiple important aspects of the eukaryotic cell cycle.
Weis
Karsten
K
Department of Molecular and Cell Biology, Division of Cell and Developmental Biology, University of California, Berkeley, Berkeley, CA 94720, USA. kweis@uclink4.berkeley.edu
D021581:Active Transport, Cell Nucleus; D020816:Amino Acid Motifs; D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D002843:Chromatin / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism*; D016678:Genome; D016681:Genome, Fungal; D007399:Interphase; D028884:Karyopherins / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship; D028961:beta Karyopherins / Q000378:metabolism; D020931:ran GTP-Binding Protein / Q000378:metabolism
D002843:Chromatin; D028884:Karyopherins; D028961:beta Karyopherins; D020931:ran GTP-Binding Protein