Multiple stable periodic solutions in a model for hormonal control of the menstrual cycle.
This study presents a nonlinear system of delay differential equations to model the concentrations of five hormones important for regulation and maintenance of the menstrual cycle. Linear model components for the ovaries and pituitary were previously analyzed and reported separately. Results for the integrated model are now presented here. This model predicts serum levels of ovarian and pituitary hormones which agree with data in the literature for normally cycling women. In addition, the model indicates the existence and stability of an abnormal cycle. Hence, the model may be used to simulate the effects of external hormone therapies on abnormally cycling women as well as the effects of exogenous compounds on normally cycling women. Such simulations may be helpful in understanding the role of xenobiotics in fertility problems, in predicting successful hormone therapies, and for testing hormonal methods of birth control.
Clark
Leona Harris
LH
Department of Mathematics, North Carolina State University, Raleigh, NC 27695-8205, USA. Harris.Leona@epamail.epa.gov
Schlosser
Paul M
PM
Selgrade
James F
JF
D000328:Adult; D003198:Computer Simulation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006801:Humans; D016014:Linear Models; D007986:Luteinizing Hormone / Q000502:physiology; D008598:Menstruation / Q000502:physiology*; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010053:Ovary / Q000502:physiology; D010507:Periodicity
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone