Apoptosis and plastic surgery.
Apoptosis, or programmed cell death, is a phenomenon that is integral to development and cellular homeostasis. In the last decade, many of the essential molecules and pathways that control this phenomenon have been elucidated. Because apoptosis is involved in almost all physiologic and pathologic processes, the understanding of its regulation has significant clinical ramifications. This article reviews the basic understanding of programmed cell death in terms of the effector molecules and pathways. Areas of interest to plastic surgeons are reviewed as they pertain to apoptosis. These areas include allotransplantation, craniofacial and limb development, flap survival, wound healing, stem cell science, and physiologic aging. These topics have not yet been studied extensively in the context of cell death. In this review article, other related and more comprehensively studied scientific areas are used to extrapolate their relevance to apoptosis. Apoptosis is an increasingly better understood process. With the knowledge of how programmed cell death is controlled, combined with the improved ability to effectively perform genetic manipulation and to design specific chemical approaches, apoptosis is gaining clinical relevance. In the next few years, practical clinical breakthroughs will help the medical community to understand the phenomenon of apoptosis and how it relates to the needs of patients.
Gastman
Brian R
BR
Department of Otolaryngology, University of Pittsburgh Shool of Medicine, Pa, USA. gastmanb@msx.upmc.edu
Futrell
J William
JW
Manders
Ernest K
EK
D000375:Aging / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D019465:Craniofacial Abnormalities / Q000503:physiopathology; D005121:Extremities / Q000196:embryology / Q000254:growth & development; D006084:Graft Rejection / Q000503:physiopathology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D013234:Stem Cells; D013524:Surgical Flaps / Q000502:physiology; D023822:Tissue Engineering; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000502:physiology