title: Novel synthesis of flavonoids of Scutellaria baicalensis Georgi.
abstract: A concise and efficient total synthesis of the flavonoids baicalein, oroxylin A and wogonin was described. Intramolecular oxidative cyclization followed by demethylation of chalcone 1, readily prepared from trimethoxyphenol, afforded, depending upon the controlled conditions, baicalein or oroxylin A in excellent yields. Demethylation of 1 yielded 3, which, by oxidation with I(2)/dimethyl sulfoxide (DMSO), was readily converted to oroxylin A and wogonin after column chromatography.
authors.affiliation: School of Pharmacy, National Defense Medical Center, Taiwan.
authors.forename: Wen-Hsin
authors.initials: WH
authors.lastname: Huang
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chien
authors.forename: Ching-Huey
authors.initials: CH
authors.lastname: Yang
authors.forename: An-Rong
authors.initials: AR
authors.lastname: Lee
mesh_terms: D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry; D031364:Scutellaria baicalensis
chemical_list: D005419:Flavonoids