title: Dihydroisocoumarins and a tetralone from Cytospora eucalypticola.
abstract: Two dihydroisocoumarins, 3,5-dimethyl-8-hydroxy-7-methoxy-3,4-dihydroisocoumarin and 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin were isolated from a culture filtrate of Cytospora eucalypticola, together with three known dihydroisocoumarins and a tetralone derivative. Their structures were determined by spectroscopic methods. These isocoumarins are mildly antifungal, and antibacterial towards gram positive bacteria. A known compound, 5-hydroxymethylmellein, showed mild antifeedant activity towards Spodoptera littoralis.
authors.affiliation: Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB, UK. t.kokubun@kew.org.uk
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kokubun
authors.forename: Nigel C
authors.initials: NC
authors.lastname: Veitch
authors.forename: Paul D
authors.initials: PD
authors.lastname: Bridge
authors.forename: Monique S J
authors.initials: MS
authors.lastname: Simmonds
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002478:Cells, Cultured; D002963:Cladosporium / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000145:classification; D019906:Nuclear Magnetic Resonance, Biomolecular; D011549:Pseudomonas / Q000187:drug effects; D018411:Spodoptera / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003374:Coumarins; D013764:Tetrahydronaphthalenes