[Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis].
Fifteen children with atopic dermatitis who had Bifidobacterium-deficient microflora were selected for this study. Eight subjects in the bifidobacteria-administered group were given oral administration of lyophilized bifidobacteria (Bifidobacterium breve M-16V strain). The changes in fecal microflora and clinical symptoms were compared with the control group. In the bifidobacteria-administered group, the proportion of Bifidobacterium in the fecal microflora was increased (P=0.0173) and the proportion of aerobic bacteria was decreased (P=0.0499) after 1 month of administration. Furthermore, significant improvement of allergic symptoms (P=0.0176 in cutaneous symptom score, P=0.0117 in total allergic score) was also observed in the bifidobacteria-administered group. The tendency of allergic symptom improvement in the bifidobacteria-administered group was remarkable compared with the control group; however there was no correlation between changes in fecal microflora and allergic symptoms.
Hattori
Kazuhiro
K
Department of Pediatrics, Kansai Medical University Kouri Hospital. hattori1127@ybb.ne.jp
Yamamoto
Akemi
A
Sasai
Misa
M
Taniuchi
Shoichiro
S
Kojima
Takatsugu
T
Kobayashi
Yohnosuke
Y
Iwamoto
Hiroshi
H
Namba
Kyoko
K
Yaeshima
Tomoko
T
D001644:Bifidobacterium; D003876:Dermatitis, Atopic / Q000382:microbiology* / Q000503:physiopathology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male