title: [Changes of element contents and their interrelationship in tibia of osteoporotic rats]
abstract: OBJECTIVE: To observe the changes of bone element contents in osteoporosis and their interrelationship. METHODS: Twelve female SD rats,10-month-old, were bilaterally ovariectomized (OVX group) and another ten rats were received sham-operation under anesthesia (SHAM group).The element contents in tibia, including Ca, P, Mg, Zn, Mn, Fe, Cu, Mo and Cr, were determined by atomic absorption spectrophotometer 7 month later. The data of contents of all elements were analyzed by simple regression. RESULTS: Compared with the SHAM group rats, the contents of Ca, P and Mg were decreased by 6.6 %(P<0.05), 6.3 %(P<0.05) and 14.9 %(P<0.01) respectively. The contents of Zn and Fe were reduced by 15.2 %(P<0.01) and 35.1 %(P<0.01) separately, Mo and Cr were decreased by 12.2 %(P>0.05) and 14.0 %(P>0.05), while the contents of Mn, Cu and Co were shown no change. There was a significant correlation among the contents of Mg, Mn, Zn, Ca and P. CONCLUSION: The contents of Ca, P, Mg, Zn and Fe were matkedly reduced in bone of osteoporotic rats induced by ovariectomy.
authors.affiliation: Callege of Biomedical Engineering and Instrument Scinces, Zhejiang University, Hangzhou 310027, China.
authors.forename: Gao-Li
authors.initials: GL
authors.lastname: ZHeng
authors.forename: Xiao-Xiang
authors.initials: XX
authors.lastname: Zheng
authors.forename: Xin-Yue
authors.initials: XY
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Wei-Gui
authors.initials: WG
authors.lastname: Gong