Proteomics: the first decade and beyond.
Proteomics is the systematic study of the many and diverse properties of proteins in a parallel manner with the aim of providing detailed descriptions of the structure, function and control of biological systems in health and disease. Advances in methods and technologies have catalyzed an expansion of the scope of biological studies from the reductionist biochemical analysis of single proteins to proteome-wide measurements. Proteomics and other complementary analysis methods are essential components of the emerging 'systems biology' approach that seeks to comprehensively describe biological systems through integration of diverse types of data and, in the future, to ultimately allow computational simulations of complex biological systems.
Patterson
Scott D
SD
Celera Genomics Corporation, 45 West Gude Drive, Rockville, Maryland 20850, USA. scottp@farmalbiomed.com
Aebersold
Ruedi H
RH
D000595:Amino Acid Sequence; D001483:Base Sequence; D002853:Chromatography, Liquid; D019295:Computational Biology; D004247:DNA / Q000235:genetics; D005821:Genetic Techniques; D049673:History, 20th Century; D049674:History, 21st Century; D013058:Mass Spectrometry / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D040901:Proteomics / Q000266:history / Q000379:methods / Q000639:trends
D011506:Proteins; D004247:DNA