[Carboxyperitoneum and clinical efficacy of nondepolarizing relaxants with different types of metabolism].
A total of 108 patients operated on the abdominal cavity were examined with laparoscopic equipment or via laparotomic assess. The recovery time of neuromuscular conduction was defined for a myorelaxant with organ-depended metabolism (pipecuronium) and, predominantly, nonorgan-depended metabolism (athracurium and cisathracurium) in relation to the type of surgical technique (laparoscopy and laparotomy). It is concluded that carboxyperitoneum prolongs the recovery of neuromuscular conduction for pipecuronium without affecting this parameter in athracurium and cisathracurium. It is more expedient to use these myorelaxants during laparoscopic operations than pipecuronium, a myorelaxant having organ-dependent metabolism.
Golovkin
A S
AS
Stamov
V I
VI
Mizikov
V M
VM
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001279:Atracurium / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009126:Muscle Relaxation / Q000187:drug effects*; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000378:metabolism* / Q000494:pharmacology; D017300:Pipecuronium / Q000378:metabolism / Q000494:pharmacology
D003473:Neuromuscular Nondepolarizing Agents; D017300:Pipecuronium; D001279:Atracurium; C101584:cisatracurium