title: Carbazole as fluorescence carrier for preparation of doxycycline sensor.
abstract: Carbazole is a promising pharmaceutical species. A novel optical sensor for determining doxycycline based on the fluorescence quenching of N-allylcarbazole immobilized on an quartz glass plate surface by covalent bonding has been described. The sensor shows satisfactory virtues in reversibility, repeatability, selectivity and sufficient lifetime resulting from its excellent optode membrane. Its response time is less than 60 s. The determination range and detection limit of the sensor are 6.0 x 10(-7)-2.0 x 10(-3) M and 2.0 x 10(-7) M, respectively. The lifetime of each sensor is at least three to four months. The sensor can be used for direct determination of doxycycline in pharmaceutical preparations and urine samples.
authors.affiliation: State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P R. China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Chen
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Niu
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Zeng
authors.forename: Guo-He
authors.initials: GH
authors.lastname: Huang
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Shen
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000652:urine; D002227:Carbazoles / Q000737:chemistry*; D004318:Doxycycline / Q000032:analysis* / Q000652:urine*; D005453:Fluorescence; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis; D011791:Quartz; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
chemical_list: D000900:Anti-Bacterial Agents; D002227:Carbazoles; D004364:Pharmaceutical Preparations; C041514:carbazole; D011791:Quartz; D004318:Doxycycline