title: Role of protein tyrosine phosphatases in T cell activation.
abstract: The last decade has seen an exponentially increasing interest in the molecular mechanisms of signal transduction. In T cells, much of the focus has been on protein tyrosine kinase (PTK)-mediated signaling from the T cell receptor (TCR) and cytokine receptors, while the study of protein tyrosine phosphatases (PTPases) has lagged behind. However, recent discoveries have revealed that several PTPases play important roles in many different aspects of T cell physiology. We predict that the phosphatases will become a 'hot topic' in the field within the next few years. This review summarizes the current understanding of the regulation and biology of PTPases in T lymphocyte activation.
authors.affiliation: Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA. tmustelin@burnham-Institute.org
authors.forename: Tomas
authors.initials: T
authors.lastname: Mustelin
authors.forename: Souad
authors.initials: S
authors.lastname: Rahmouni
authors.forename: Nunzio
authors.initials: N
authors.lastname: Bottini
authors.forename: Andres
authors.initials: A
authors.lastname: Alonso
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D006801:Humans; D017493:Leukocyte Common Antigens / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000201:enzymology*
chemical_list: D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases