title: Stevens-Johnson syndrome with idiopathic thrombocytopenic purpura treated with dexamethasone pulse therapy.
abstract: Stevens-Johnson syndrome (SJS) is a severe, episodic, acute, mucocutaneous hypersensitivity reaction often caused by drugs. We herewith report a case of SJS with idiopathic thrombocytopenic purpura (ITP) that did not respond to daily oral prednisolone therapy. When treated with dexamethasone pulse therapy, the response was found to be very good. Therefore, we concluded that dexamethasone pulse therapy can be a good and an effective alternative therapy for treatment of such patients. However, to establish its role, further trials in more patients are needed.
authors.affiliation: Department of Dermatology and Venereology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
authors.forename: Krishna Deb
authors.initials: KD
authors.lastname: Barman
authors.forename: Kaushal K
authors.initials: KK
authors.lastname: Verma
authors.forename: Sudha
authors.initials: S
authors.lastname: Agrawal
authors.forename: Arun
authors.initials: A
authors.lastname: Agarwalla
authors.forename: Arpana
authors.initials: A
authors.lastname: Rijal
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006801:Humans; D007262:Infusions, Intravenous; D035002:Lower Extremity; D008297:Male; D020551:Pulse Therapy, Drug; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D012611:Scrotum; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone