title: Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease.
abstract: OBJECTIVE
  To directly compare dynamic susceptibility contrast (DSC) and continuous arterial spin labeled (CASL) magnetic resonance (MR) perfusion techniques in patients with known cerebrovascular disease, with the goals of identifying possible pitfalls in interpretation and determining potential for a complementary role in this setting.
  
  
  METHODS
  DSC and CASL MR perfusion studies were performed and compared in 11 patients with acute and/or chronic cerebrovascular disease. Using an automated segmentation technique, Pearson correlation coefficients were generated for CASL perfusion measurements compared to DSC perfusion maps (time-to-peak [TTP], relative cerebral blood volume [rCBV], cerebral blood flow [rCBF], and mean transit time [MTT]) by hemisphere and vascular territory.
  
  
  RESULTS
  TTP maps obtained using DSC perfusion MR correlated best both subjectively and objectively with CASL perfusion MR measurements when all patients studied were considered. If patients with a major transit delay were excluded, DSC rCBF correlated best with CASL CBF measurements.
  
  
  CONCLUSIONS
  There may be a complementary role for CASL and DSC perfusion MR methods in cerebrovascular disease, especially in the setting of a marked transit delay.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. wolf@rad.upenn.edu
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wolf
authors.forename: David C
authors.initials: DC
authors.lastname: Alsop
authors.forename: Michael L
authors.initials: ML
authors.lastname: McGarvey
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Maldjian
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D013113:Spin Labels
chemical_list: D013113:Spin Labels