title: Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).
abstract: We sought to examine prospectively the association of serum homocysteine and the methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism with risk of venous thromboembolism (VTE). We studied these relationships in a nested case-control study of 303 VTE cases and 635 matched controls from a population-based cohort of 21,680 adults from six U.S. communities. The highest quintile of serum homocysteine carried a non-statistically significant adjusted odds ratio of 1.55 (95% CI, 0.93-2.58) compared to the lowest quintile in the overall cohort but a significant association among adults aged 45-64 years (OR = 2.05, 95% CI, 1.10-3.83) and an inverse association in those > or = 65 years of age. Carriers of the MTHFR C677T polymorphism were not at higher risk for VTE than those with normal genotype (OR = 0.74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA.
authors.forename: Albert W
authors.initials: AW
authors.lastname: Tsai
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Rosamond
authors.forename: Nena
authors.initials: N
authors.lastname: Aleksic
authors.forename: N David
authors.initials: ND
authors.lastname: Yanez
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
mesh_terms: D000368:Aged; D000375:Aging; D000818:Animals; D016022:Case-Control Studies; D015331:Cohort Studies; D005165:Factor V; D005260:Female; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D016017:Odds Ratio; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood* / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)