title: Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women.
abstract: A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno-Gu, Seoul, Korea.
authors.forename: K-M
authors.initials: KM
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Abel
authors.forename: Y
authors.initials: Y
authors.lastname: Ko
authors.forename: V
authors.initials: V
authors.lastname: Harth
authors.forename: W-Y
authors.initials: WY
authors.lastname: Park
authors.forename: J-S
authors.initials: JS
authors.lastname: Seo
authors.forename: K-Y
authors.initials: KY
authors.lastname: Yoo
authors.forename: J-Y
authors.initials: JY
authors.lastname: Choi
authors.forename: A
authors.initials: A
authors.lastname: Shin
authors.forename: S-H
authors.initials: SH
authors.lastname: Ahn
authors.forename: D-Y
authors.initials: DY
authors.lastname: Noh
authors.forename: A
authors.initials: A
authors.lastname: Hirvonen
authors.forename: D
authors.initials: D
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D001141:Aromatase / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D001483:Base Sequence; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D017931:DNA Primers; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D017931:DNA Primers; D001141:Aromatase; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1