title: Alternative solvents for elevated-temperature solid-phase parallel synthesis. Application to thionation of amides.
abstract: A new class of higher-boiling solvents was investigated for elevated-temperature solid-phase parallel synthesis. Extremely low vapor pressures at high temperature and a broader range of solvent effect tuning make this new class of solvents an ideal choice for high-temperature parallel solid-phase synthesis. Benzyl benzoate is identified as a superior high-boiling solvent for parallel solid-phase Lawesson's thionation reactions.
authors.affiliation: Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776, USA. scoats@prdus.jnj.com
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Coats
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Link
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Hlasta