Membrane domains in the secretory and endocytic pathways.
Progress in identifying, characterizing, and localizing the constituents of distinct membrane bound compartments has revealed a new level of intracellular subcompartmentation. Proteins and lipids are not uniformly distributed in a given organelle, and subdomains are formed by a combination of hierarchical assembly processes and protein exclusion. Thus, functionally distinct specializations of a given organelle are physically segregated to a greater extent than previously believed.
Pfeffer
Suzanne
S
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA. pfeffer@stanford.edu
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000502:physiology* / Q000648:ultrastructure; D011992:Endosomes / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D021601:trans-Golgi Network / Q000502:physiology
D020691:rab GTP-Binding Proteins