title: Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease.
abstract: OBJECTIVE
  To investigate whether endolymphatic hydrops in Ménière's Disease could be diagnosed by comparing vestibular evoked myogenic potential (VEMP) before and after furosemide administration (F-VEMP).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Furosemide administration.
  
  
  METHODS
  Twenty-five affected ears of patients with unilateral Ménière's Disease were studied. The patients had received confirmed diagnoses Ménière's Disease; thus, the presence of endolymphatic hydrops was suggested. For the control, 22 ears of 11 normal healthy volunteers who had never had vertigo or hearing disturbance were used.
  
  
  METHODS
  The amplitude of the p13-n23 biphasic wave before and after furosemide administration.
  
  
  RESULTS
  The amplitude of the p13-n23 biphasic wave was significantly enlarged in 7 of 18 cases in which it could be detected before diuretic loading. The biphasic waves appeared after diuretic loading in 3 of 7 cases in which it could not be recorded before loading. Thus, the positive ratio of F-VEMP for unilateral Ménière's Disease was considered to be 40% (10 of 25). The ratio was similar to that of the conventional examinations for endolymphatic hydrops such as the glycerol test, furosemide test, and electrocochleogram.
  
  
  CONCLUSIONS
  The F-VEMP test may be useful in the diagnosis of endolymphatic hydrops.
authors.affiliation: Department of Otolaryngology, Hyogo College of Medicine, Nishiniomiya, Japan. tseo@hyo-med.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Seo
authors.forename: Michiko
authors.initials: M
authors.lastname: Node
authors.forename: Akiko
authors.initials: A
authors.lastname: Yukimasa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sakagami
mesh_terms: D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005665:Furosemide / Q000008:administration & dosage; D005990:Glycerol; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D012720:Severity of Illness Index; D016683:Supine Position; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000503:physiopathology*
chemical_list: D004232:Diuretics; D005665:Furosemide; D005990:Glycerol