Effects of short-term treatment of solasodine on cauda epididymis in dogs.
Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides. The cells became atrophic and the lumen was devoid of spermatozoa. Castration followed by the adminstration of solasodine further reduced the epithelial cell height in comparison to castrated controls. Concurrent treatment of solasodine along with testosterone propionate was unable to restore the normal epithelial lumen parameters. Total protein, sialic acid, glycogen and acid phosphatase activities were significantly reduced in solasodine treated cauda epididymides. These result suggest antiandrogenic potency of solasodine.
Gupta
R S
RS
Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302 004, India.
Dixit
V P
VP
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D004822:Epididymis / Q000187:drug effects*; D004847:Epithelial Cells / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D010936:Plant Extracts; D012991:Solanaceous Alkaloids; D013739:Testosterone; D006003:Glycogen; D000135:Acid Phosphatase; D019158:N-Acetylneuraminic Acid; C012037:solasodine