title: Important drug interactions and reactions in dermatology.
abstract: A constantly expanding pharmacological armamentarium increases the concern for serious drug interactions. This article discusses drug metabolism and how the cytochrome P-450 family facilitates drug biotransformation. Clinically significant drug interactions involving antifungal drugs, antibiotics, retinoids, and immunosuppressive agents, as well as topical anesthetics and various foods, are included.
authors.affiliation: Georgetown University Medical Center, 3800 Reservoir Road NW 5-PHC Dermatology, Washington, DC 20007, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Aria
authors.forename: C Lisa
authors.initials: CL
authors.lastname: Kauffman
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003879:Dermatologic Agents / Q000009:adverse effects / Q000378:metabolism; D004347:Drug Interactions / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008012:Lidocaine / Q000009:adverse effects; D000077442:Lidocaine, Prilocaine Drug Combination; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011318:Prilocaine / Q000009:adverse effects
chemical_list: D000890:Anti-Infective Agents; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D000077442:Lidocaine, Prilocaine Drug Combination; D004364:Pharmaceutical Preparations; D011318:Prilocaine; D003577:Cytochrome P-450 Enzyme System; D008012:Lidocaine