[On the mechanisms of radiobiological events in relation to the regulatory role of p53 gene and protein].
The paper analyzes the topical problems of radiobiology in the light of the present-day data on the molecular biology and biochemistry of p53 protein that is an integrator of stress signals from various damaging exposures and that fulfills the function of genome guard by regulating the checking points of a cellular cycle, DNA reparation, and apoptosis. It also considers the mechanisms of radiation cell death and radiosensitivity/radioresistance in the light of data on p53 protein, as well as the problems of searching for antiradiation agents, the radiation-induced instability of genome, the biological aftereffects of small-dose radiation, as well as radiation-induced carcinogenesis due to the important regulatory role of p53 protein. The lines of further studies of the above problems are outlined to refine the understanding of pathogenetic processes in radiation damages, to extend the therapeutic, diagnostic, predictive capacities of clinical radiobiology and radiation medicine.
Mazurik
V K
VK
Moroz
B B
BB
D000818:Animals; D017209:Apoptosis / Q000502:physiology / Q000528:radiation effects; D002453:Cell Cycle / Q000502:physiology / Q000528:radiation effects; D002477:Cells / Q000528:radiation effects; D004260:DNA Repair / Q000502:physiology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D016678:Genome; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000235:genetics; D011837:Radiation-Protective Agents / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*
D011837:Radiation-Protective Agents; D016159:Tumor Suppressor Protein p53