title: Cure of metastatic uterine carcinosarcoma to lungs: a case report.
abstract: Most patients with advanced or recurrent uterine sarcoma experience disease progression and ultimately die. We present a case of uterine sarcoma with lung metastasis treated with systemic chemotherapy and with no evidence of disease for more than 5 years. A 77-year-old woman underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for carcinosarcoma of the uterus followed by external pelvic radiotherapy. Ten months later, the tumor recurred in the apex of the vagina and was treated with brachytherapy. After 6 months of remission, she presented with pulmonary metastasis. After four cycles of systemic chemotherapy with cisplatin and ifosfamide, the pulmonary nodules completely disappeared. Currently she is still in complete remission after more than 5 years, but unfortunately she has developed myelodysplastic syndrome. This is the first reported case in the literature of cured metastatic uterine carcinosarcoma to lungs, with long-term survival of 5 years.
authors.affiliation: Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Shamseddine
authors.forename: A
authors.initials: A
authors.lastname: Taher
authors.forename: Y
authors.initials: Y
authors.lastname: Abou-Mourad
authors.forename: M
authors.initials: M
authors.lastname: Seoud
authors.forename: A
authors.initials: A
authors.lastname: Khalil
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002296:Carcinosarcoma / Q000188:drug therapy* / Q000556:secondary* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D014594:Uterine Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D002945:Cisplatin; D007069:Ifosfamide