Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery.
Kappa-opioid receptor mediates both immediate and delayed cardioprotection of ischemic/metabolic inhibition preconditioning. Both PKC and mitochondria ATP-sensitive K+ channel, mediate the protective action of kappa-opioid receptor stimulation. In delayed cardioprotection, PKC-epsilon may produce its effect via mitochondria ATP-sensitive K+ channel, and a stress inducible heat stress protein 70 may also be involved. Metabolic inhibition causes cell death which is accompanied by Ca2+ overload and mobilization of Ca2+ from sarcoplasmic reticulum to cytoplasm. The altered Ca2+ homeostasis is restored partially by kappa-opioid receptor or metabolic inhibition preconditioning. The finding indicates that opioids such as morphine may be used in the treatment of ischemic heart diseases and in open heart surgery.
Wong
Tak Ming
TM
Department of Physiology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. wongtakm@hkucc.hku.hk
Wu
Song
S
D000701:Analgesics, Opioid / Q000627:therapeutic use; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D009020:Morphine / Q000627:therapeutic use; D017202:Myocardial Ischemia / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017473:Receptors, Opioid, kappa / Q000502:physiology*
D000701:Analgesics, Opioid; D017473:Receptors, Opioid, kappa; D009020:Morphine; D002118:Calcium