[Is a cataract avoidable? Current status with special emphasis on the pathophysiology of oxidative lens damage, nutritional factors, and the ARED study].
The benefit of long-term nutrient intake to reduce the risk of age-related ocular disease such as cataract or macular degeneration is subject to controversy. Conclusions about the benefits and risks of antioxidant supplements can be expected after reviewing the current literature concerning oxidative-induced lens damage and nutritional effects. Identification of influenceable risk factors for senile cataracts could achieve immense economical relevance. In contrast to former longitudinal epidemiological studies, the AREDS report failed to verify protective properties of highly concentrated vitamin supplements on cataract formation. Although there are enough epidemiological indications for reducing the risk of cataracts by the intake of antioxidants, a general recommendation for the use of supplements is untimely or even wrong until stringent evidence of efficacy is provided. The usefulness of cataract prevention is discussed.
Kottler
U B
UB
Augenklinik mit Poliklinik der Johannes Gutenberg-Universität Mainz. kottler@augen.klinik.uni-mainz.de
Dick
H B
HB
Augustin
A J
AJ
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000009:adverse effects; D002386:Cataract / Q000503:physiopathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects* / Q000503:physiopathology; D008134:Long-Term Care; D008268:Macular Degeneration / Q000503:physiopathology / Q000517:prevention & control; D018977:Micronutrients / Q000008:administration & dosage* / Q000009:adverse effects; D015337:Multicenter Studies as Topic; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000975:Antioxidants; D018977:Micronutrients