title: Axonal transport of membranous and nonmembranous cargoes: a unified perspective.
abstract: Membranous and nonmembranous cargoes are transported along axons in the fast and slow components of axonal transport, respectively. Recent observations on the movement of cytoskeletal polymers in axons suggest that slow axonal transport is generated by fast motors and that the slow rate is due to rapid movements interrupted by prolonged pauses. This supports a unified perspective for fast and slow axonal transport based on rapid movements of diverse cargo structures that differ in the proportion of the time that they spend moving. A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1) accompanies this Mini-Review.
authors.affiliation: The Ohio State University, Neurobiotechnology Center, Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA. brown.2302@osu.edu
authors.forename: Anthony
authors.initials: A
authors.lastname: Brown
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D020409:Molecular Motor Proteins / Q000502:physiology; D009420:Nervous System / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D011108:Polymers / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology
chemical_list: D046911:Macromolecular Substances; D020409:Molecular Motor Proteins; D011108:Polymers