title: Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus.
abstract: The crude extracts of the leaves of Dodonaea viscosa and Rumex nervosus as well as of the root of Rumex abyssinicus were tested for anti-microbial and anti-inflammatory activities. It was observed that the three plants possess antibacterial activity against Streptococcus pyogenes and Staphylococcus aureus and strong activity against Coxsackie virus B3 and influenza A virus. In contrast, none of them exhibited anti-fungal activity. The anti-inflammatory activity test results verified that only R. abyssinicus inhibited the synthesis of prostaglandin (PG) E(2).
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia.
authors.forename: M
authors.initials: M
authors.lastname: Getie
authors.forename: T
authors.initials: T
authors.lastname: Gebre-Mariam
authors.forename: R
authors.initials: R
authors.lastname: Rietz
authors.forename: C
authors.initials: C
authors.lastname: Höhne
authors.forename: C
authors.initials: C
authors.lastname: Huschka
authors.forename: M
authors.initials: M
authors.lastname: Schmidtke
authors.forename: A
authors.initials: A
authors.lastname: Abate
authors.forename: R H H
authors.initials: RH
authors.lastname: Neubert
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018517:Plant Roots; D031804:Rumex; D029631:Sapindaceae
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts