title: Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark.
abstract: The extracts as well as piperolactum C, goniopedaline, 6beta-hydroxystigmasta-4,22-dien-3-one and a mixture of cis- and trans-4-hydroxymelleins obtained from Uvaria hamiltonii stem bark exhibited mild to moderate in vitro antibacterial activity. The results obtained were compared with a standard antibiotic, kanamycin. In a brine shrimp lethality bioassay the pet-ether, dichloromethane, methanol extracts and a major alkaloid, piperolactum C were found to exhibit mild to moderate cytotoxicity.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Science, University of Dhaka, Dhaka 1000, Bangladesh.
authors.forename: K N
authors.initials: KN
authors.lastname: Asha
authors.forename: R
authors.initials: R
authors.lastname: Chowdhury
authors.forename: C M
authors.initials: CM
authors.lastname: Hasan
authors.forename: M A
authors.initials: MA
authors.lastname: Rashid
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007612:Kanamycin / Q000494:pharmacology; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031046:Uvaria
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D007612:Kanamycin