title: The effect of treatment with a 1% injectable formulation of moxidectin during the rainy season and at the beginning of the dry season on gastrointestinal nematodes in cattle from communal areas in Zimbabwe.
abstract: The effect of 1% moxidectin/cydectin at 0.2 mg/kg live weight on gastrointestinal nematodes and on the growth of calves, weaners and cows was investigated in five communal areas on the highveld of Zimbabwe. Three field experiments were carried out between March 1996 and June 1997. In experiment 1, treatment was administered in all five areas at the end of the rainy season in March 1996, followed by a further treatment at the beginning of the dry season in May/June 1996. In experiment 2, the treatment was administered in three areas at the end of the rainy season in March 1997. In experiment 3, treatment was administcred in one area at the beginning of the dry season in April 1997. Large numbers of eggs were present in the faeces of calves and weaners at the start of experiments 1 and 2. Epg values were lower in cows and in all age categories in experiment 3. There was a statistically significant reduction in epg values in calves, weaners and cows following treatment with a reduction of 90-99% in all cases except in cows in experiment 3, where no meaningful assessment was possible owing to the low egg counts in both the treated and control cows. The dominating larval types in faecal cultures were Cooperia and Haemonchus. Trichostrongylus, Oesophagostomum and Bunostomum were also found. Following treatment, Haemonchus was suppressed far more than Cooperia. This may be related to a longer residual effect against abomasal parasites like Haemonchus in comparison to small intestinal worms like Cooperia. Anthelmintic treatment conferred significant weight gain advantages (p < 0.05) on treated calves. weaners and cows. The weight gains are discussed in relation to disease and nutrition.
authors.affiliation: Department of Paraclinical Veterinary Studies, University of Zimbabwe, PO Box MP 167, Mt. Pleasant, Harare, Zimbabwe. DZMoyo@Hotmail.com
authors.forename: D Z
authors.initials: DZ
authors.lastname: Moyo
authors.forename: W M L
authors.initials: WM
authors.lastname: Hendrikx
authors.forename: M J
authors.initials: MJ
authors.lastname: Obwolo
authors.forename: M
authors.initials: M
authors.lastname: Eysker
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology*; D002980:Climate; D005243:Feces / Q000469:parasitology; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D007267:Injections / Q000662:veterinary; D007420:Intestine, Large / Q000469:parasitology; D018942:Macrolides; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D012621:Seasons; D014251:Trichostrongyloidea / Q000254:growth & development*; D014252:Trichostrongyloidiasis / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary*; D015030:Zimbabwe
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin