title: [Acute normovolemic hemodilution together with aprotinin applied as a scheme of blood saving in cardiac surgery].
abstract: The risk of blood loss in open heart surgery procedures is related to a high level of homologous blood transfusion. Due to numerous possible complications connected with transfusion, as well as the increase in prices of blood preparations, methods of blood saving are of great interest. The aim of the study was to assess acute normovolemic hemo-dilution (ANH) efficacy and aprotinin administration in homologous blood usage limitations. The study was conducted in the group of 265 patients operated on during the period of 12 months. The control group consisted of patients operated on during the period 6 months. The scheme of ANH with the administration of aprotinin was applied in the second half-year period. A statistically significant reduction in the percentage of patients who required blood transfusions was observed (77.2%/53%). The scheme applied enabled to reduce procedure costs in regard to blood preparation purchase. The results have shown that ANH together with antifibrinolytic drug administration is not only an efficient but also profitable strategy of blood saving.
authors.affiliation: Klinika Kardiochirurgii AM 15-276 Białystok ul. M. Skłodowskiej-Curie 24a.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Pawlak
authors.forename: Bronisław
authors.initials: B
authors.lastname: Czech
authors.forename: Ewa
authors.initials: E
authors.lastname: Kucewicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Szapiel
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Juszczyk
authors.forename: Marek
authors.initials: M
authors.lastname: Frank
mesh_terms: D007611:Aprotinin / Q000627:therapeutic use*; D001772:Blood Cell Count; D016913:Blood Component Transfusion / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001810:Blood Volume / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D013997:Time Factors
chemical_list: D006490:Hemostatics; D007611:Aprotinin