title: Efficacy of ADCON-T/N after primary flexor tendon repair in Zone II: a controlled clinical trial.
abstract: A prospective double-blind, randomized, controlled clinical trial was conducted to assess the use of ADCON-T/N after flexor tendon repair in Zone II. Forty-five patients with 82 flexor tendon repairs in 50 digits completed the study. ADCON-T/N was injected into the tendon sheath after tenorrhaphy in the experimental group while the control group was not treated with ADCON-T/N. ADCON-T/N had no statistically significant effect on total active motion at 3, 6 and 12 months but the time taken to achieve the final range of motion was significantly shorter in treated patients. ADCON-treated patients had a higher rupture rate but this was not significant.
authors.affiliation: Department of Plastic Surgery, Wythenshawe Hospital, Wythenshawe, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Golash
authors.forename: A
authors.initials: A
authors.lastname: Kay
authors.forename: J G
authors.initials: JG
authors.lastname: Warner
authors.forename: F
authors.initials: F
authors.lastname: Peck
authors.forename: J S
authors.initials: JS
authors.lastname: Watson
authors.forename: V C
authors.initials: VC
authors.lastname: Lees
mesh_terms: D000328:Adult; D002241:Carbohydrates / Q000627:therapeutic use*; D004311:Double-Blind Method; D005383:Finger Injuries / Q000601:surgery*; D005782:Gels; D006801:Humans; D011108:Polymers / Q000627:therapeutic use*; D011446:Prospective Studies; D016059:Range of Motion, Articular; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: C101549:ADCON-T-N; D002241:Carbohydrates; D005782:Gels; D011108:Polymers