title: Widespread morphoea following radiotherapy for carcinoma of the breast.
abstract: We report a case of a 60-year-old lady who was treated with radiotherapy for breast cancer of both breasts 8 years apart. Thirteen years after the first dose of radiotherapy she developed localized morphoea in all the irradiated skin of the chest wall and also the gaiter regions of both lower legs. Radiation-induced localized morphoea has been previously reported; however, there is no previous publication of an occurrence at a distant site as in this case. This case demonstrates that morphoea can occur distant to the original breast carcinoma and site of radiotherapy. We postulate that radiotherapy can induce neoantigen formation, which initiates a T cell response and subsequent tissue growth factor alpha release. Tissue growth factor alpha induces fibroblast activation and collagen production may persist due to a positive feedback mechanism within the fibroblast. The reason why the disease did not generalize remains unclear.
authors.affiliation: Department of Dermatology, Royal Berkshire Hospital, Reading, UK. mikeaj@talk21.com
authors.forename: M R
authors.initials: MR
authors.lastname: Ardern-Jones
authors.forename: M M
authors.initials: MM
authors.lastname: Black
mesh_terms: D001940:Breast / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000209:etiology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000532:radiotherapy; D011832:Radiation Injuries / Q000150:complications*; D012594:Scleroderma, Localized / Q000209:etiology*