title: Prognostic value of preoperative immunosuppressive acidic protein levels in patients with gastric carcinoma.
abstract: OBJECTIVE
  Immunosuppressive acidic protein has been found to suppress both phytohemagglutinin-induced lymphocyte blast formation and mixed lymphocyte reaction in vitro. The level of immunosuppressive acidic protein has revealed clear increases with the progression of cancer, and has been reported to be a useful diagnostic and follow-up marker for ovarian and renal cancer. We examined immunosuppressive acidic protein levels in patients with gastric cancer to examine the influence of clinical parameters.
  
  
  METHODS
  The present study was based on a retrospective analyses of data on 107 patients with gastric cancer, all of whom had been surgically treated in the Department of Surgery II, Kyushu University Hospital from 1988 to 1992. All patients were examined for immunosuppressive acidic protein level, based on a peripheral blood sampling done preoperatively.
  
  
  RESULTS
  Significant associations among immunosuppressive acidic protein level and clinicopathological parameters, including lymphatic involvement, vascular involvement, and lymph node metastases were evident. The 5-year survival rates were 75.9% and 92.1% for those with immunosuppressive acidic protein level > or = 355 and < 355, respectively, the value being statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  These data show that immunosuppressive acidic protein levels may be related to lymph node metastases. Measurement of preoperative immunosuppressive acidic protein levels may be pertinent for the prognosis of patients with gastric cancer and for follow-up clinical management.
authors.affiliation: Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Hideya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.forename: Eriko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Koga
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kakeji
authors.forename: Keizo
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate
chemical_list: D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein