title: Malignant peripheral nerve sheath tumor with divergent differentiation.
abstract: Right posterior thigh malignant peripheral nerve sheath tumor with malignant glandular and rhabdomyoblastic components was diagnosed in a 24-year-old African American man. Malignant glands and rhabdomyoblastic cells were admixed with the spindle cells. Immunohistochemistry demonstrated spindle cells positive for S100 and vimentin; the glandular component was positive for chromogranin, and rare cells were positive for CK20 but negative for CK7. Rhabdomyoblastic cells were positive for muscle-specific actin and desmin. A single pulmonary metastasis occurred 5 months after surgical resection of the tumor. Death occurred 1 month later and was probably due to a pulmonary embolus.
authors.affiliation: Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112-1393, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Carmen
authors.initials: C
authors.lastname: Espinoza
authors.forename: Ronald
authors.initials: R
authors.lastname: Welsh
mesh_terms: D000328:Adult; D004847:Epithelial Cells / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis*; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000556:secondary