Error theory and ageing in human diploid fibroblasts.
Immunological and enzymatic assessments of lactate dehydrogenase in human lung fibroblasts strongly suggest that altered proteins accumulate in ageing cells. This supports but does not prove the error catastrophe theory of all death.
Lewis
C M
CM
National Institute for Medical Research, Mill Hill.
Tarrant
G M
GM
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002452:Cell Count; D016923:Cell Death; D016922:Cellular Senescence / Q000502:physiology*; D003851:Deoxyribonucleases / Q000378:metabolism; D004171:Diploidy; D005001:Ethionine / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D008168:Lung; D008715:Methionine / Q000378:metabolism; D008954:Models, Biological; D014176:Protein Biosynthesis; D012260:Ribonucleases / Q000378:metabolism
D000596:Amino Acids; D008715:Methionine; D007770:L-Lactate Dehydrogenase; D003851:Deoxyribonucleases; D012260:Ribonucleases; D005472:Fluorouracil; D005001:Ethionine