title: Epidermal growth factor receptor: mechanisms of activation and signalling.
abstract: The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
authors.affiliation: Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Jorissen
authors.forename: Francesca
authors.initials: F
authors.lastname: Walker
authors.forename: Normand
authors.initials: N
authors.lastname: Pouliot
authors.forename: Thomas P J
authors.initials: TP
authors.lastname: Garrett
authors.forename: Colin W
authors.initials: CW
authors.lastname: Ward
authors.forename: Antony W
authors.initials: AW
authors.lastname: Burgess
mesh_terms: D000818:Animals; D002465:Cell Movement; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction; D015291:Transforming Growth Factors / Q000378:metabolism
chemical_list: D015291:Transforming Growth Factors; D066246:ErbB Receptors