Cytotoxic activity and quality control determinations on Chelidonium majus.
The quality control determinations on herba and radix Chelidonii prepared from Chelidonium majus L., growing wildly in Bursa, Uludağ surroundings, have been conducted according to DAB 9. Ash, humidity and total alkaloidal content have been carried out. LC(50) value of chelidonine and protopine, the most important alkaloids, and the alcoholic and water extracts of herba Chelidonii were determined using brine shrimp (Artemia salina) lethality bioassay.
Saglam
H
H
Department of Pharmacognosy, Faculty of Pharmacy, University of Ege, Bornova, Izmir 35100, Turkey. saglamh@pharm.ege.edu.tr
Arar
G
G
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001156:Artemia / Q000187:drug effects*; D028281:Chelidonium; D007928:Lethal Dose 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
D000470:Alkaloids; D010936:Plant Extracts