[Reproductive toxicity of lindane].
The present paper bears on the main effects of lindane (gamma isomer of hexachlorocyclohexane) on endocrine and reproductive functions in mammals. This pesticide, once widely used to kill lice and a variety of pests that attack agricultural products, livestock and trees, has been progressively eliminated from many applications since the mid-1970s in Europe or USA, but is still used in the rest of the world. Lindane is absorbed through respiratory, digestive or cutaneous routes and accumulates in fat tissues. It damages human liver, kidney, neural and immune systems and induces birth defects, cancer and death. Chronic administration results in endocrine disruption in birds as well as in mammals. Treatment with 1-40 mg of lindane/kg b.w. disrupts testicular morphology, decreases spermatogenesis, inhibits testicular steroidogenesis, reduces plasma androgen concentrations and may adversely affect reproductive performances in males. In females, lindane disrupts the estrous cycle, reduces serum estrogen and progesterone levels, decreases sexual receptivity whereas in pregnant dams it decreases whelping rate and litter size. These effects were also observed in some rats exposed to residual environmental doses. In addition, there is concern that irreversible effects may be induced when animals are exposed to endocrine disrupting chemicals during critically susceptible phases of sexual differentiation or development. These effects would results from (i) alterations of gonade or gamete cell membranes (ii) cell metabolism changes including alterations of ionic exchanges (mainly calcium or potassium), direct or free radical-mediated inhibition of steroidogenesis (iii) or neuroendocrine changes leading to a decrease in sexual performance of either parents or their offsprings exposed in utero or through lactation.
Pagès
Nicole
N
Laboratoire de Toxicologie, Faculté de Pharmacie, Route du Rhin, 67400 Illkirch, France.
Sauviat
Martin-Pierre
MP
Bouvet
Suzanne
S
Goudey-Perrière
Françoise
F
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001715:Bird Diseases / Q000139:chemically induced; D001717:Birds; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D006066:Gonads / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007306:Insecticides / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity*; D008297:Male; D008322:Mammals; D051379:Mice; D010573:Pesticide Residues / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011817:Rabbits; D051381:Rats; D017382:Reactive Oxygen Species; D012098:Reproduction / Q000187:drug effects*; D012756:Sheep; D013091:Spermatogenesis / Q000187:drug effects; D013256:Steroids / Q000378:metabolism; D014018:Tissue Distribution
D007306:Insecticides; D010573:Pesticide Residues; D017382:Reactive Oxygen Species; D013256:Steroids; D001556:Hexachlorocyclohexane