title: Dynamical synaptic plasticity: a model and connection to some experiments.
abstract: Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745-755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.
authors.affiliation: Institute for Nonlinear Science, University of California, San Diego 92093-0402, USA.
authors.forename: A
authors.initials: A
authors.lastname: Whitehead
authors.forename: M I
authors.initials: MI
authors.lastname: Rabinovich
authors.forename: R
authors.initials: R
authors.lastname: Huerta
authors.forename: V P
authors.initials: VP
authors.lastname: Zhigulin
authors.forename: Henry D I
authors.initials: HD
authors.lastname: Abarbanel
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology; D008959:Models, Neurological; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D051381:Rats; D015203:Reproducibility of Results; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology