title: Neuronal or glial progeny: regional differences in radial glia fate.
abstract: The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical projection neurons but not the interneurons originating in the ventral telencephalon. In contrast to the cerebral cortex, few neurons in the basal ganglia originate from radial glia, and in vitro lineage analysis revealed intrinsic differences in the potential of radial glia from the dorsal and ventral telencephalon. This shows that the progeny of radial glia not only differs profoundly between brain regions but also includes the majority of neurons in some parts of the CNS.
authors.affiliation: Max-Planck Institute of Neurobiology, Am Klopferspitz 18A, D-82152 Planegg-Martinsried, Germany.
authors.forename: Paolo
authors.initials: P
authors.lastname: Malatesta
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hack
authors.forename: Eva
authors.initials: E
authors.lastname: Hartfuss
authors.forename: Helmut
authors.initials: H
authors.lastname: Kettenmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Klinkert
authors.forename: Frank
authors.initials: F
authors.lastname: Kirchhoff
authors.forename: Magdalena
authors.initials: M
authors.lastname: Götz
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000737:chemistry / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000737:chemistry / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D019426:Integrases / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009434:Neural Pathways / Q000737:chemistry / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D009457:Neuroglia / Q000737:chemistry* / Q000502:physiology; D009474:Neurons / Q000737:chemistry* / Q000502:physiology; D014764:Viral Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases