title: Laminin-5 gamma2 chain expression as a possible determinant of tumor aggressiveness in T1 colorectal carcinomas.
abstract: This study was undertaken to clarify the associations between laminin-5 y2 chain expression, and tumor budding and lymph node metastasis or local recurrence (locoregional failure) of 50 T1 colorectal carcinomas immunohistochemically. Fifteen (30%) of 50 lesions were positive for laminin-5 gamma2 chain expression. By univariate analysis, less histological differentiation (P = 0.02), nonpolypoid growth pattern (P = 0.03) and tumorbudding (P < 0.001) were associated with laminin-5 gamma2 chain positivity. By multivariate analysis, tumor budding alone was significantly associated with laminin-5 gamma2 chain positivity (P = 0.006), and correlation between nonpolypoid growth pattern and laminin-5 gamma2 chain positivity lost its significance (P = 0.09). Tumor budding (P = 0.004) and laminin-5 gamma2 chain expression (P = 0.001) were significantly associated with locoregional failure. Laminin-5 gamma2 chain expression may contribute to the formation of budding tumor cells at the invasive front, and immunostaining of this adhesion molecule may be useful in identifying high-risk patients for locoregional failure in T1 colorectal carcinomas.
authors.affiliation: First Department of Surgery, Kyorin University, 6-20-2, Shinkawa, Mitaka city Tokyo 181-8611, Japan.
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Masaki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Masanori
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Nobutsugu
authors.initials: N
authors.lastname: Abe
authors.forename: Yumi
authors.initials: Y
authors.lastname: Izumisato
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Atomi
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000556:secondary; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis / Q000378:metabolism*; D016015:Logistic Models; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C400567:LAMC2 protein, human; D007797:Laminin