The calculus of immunity: quantitating antigen processing.
Peptide ligands destined for binding MHC class I molecules are generated by the proteasome in the cytoplasm and transported to the endoplasmic reticulum for loading onto newly synthesized class I molecules. A new study now provides a quantitative analysis of how total protein turnover in the cell relates to the efficiency of generating peptide epitopes presented by class I molecules.
Lehner
Paul J
PJ
Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, CB2 2XY, Cambridge, United Kingdom. pjl30@cam.ac.uk
D000818:Animals; D017951:Antigen Presentation; D000939:Epitopes / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008024:Ligands; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D008024:Ligands; D010455:Peptides