[Risk factors in women with gestational diabetes mellitus].
OBJECTIVE
To identify risk factors for gestational diabetes mellitus (GDM) in women and to study the contribution of family history of type-2 diabetes to the risk for DDM.


METHODS
A case-control study was performed in 85 women with GDM and 177 cases controls. Univariate and multivariate logistic regression and log-linear model were used to identify risk factors of GDM.


RESULTS
Multivariate logistic regression showed that obesity before pregnancy, family history of type-2 diabetes, birth weight of pregnant women, age, fasting plasma level of triglyceride, physical inactivity, etc. all were risk factors for GDM. Analysis with log-linear model showed that parents' (father's or mother's) history of type-2 diabetes associated with GDM, with P-values of 0.012 and 0.017, respectively. Prevalence of diabetes in the mothers of proband with GDM was 9.41%, as compared with that in the fathers of proband with GDM 8.24%, with no statistical significance.


CONCLUSIONS
Obesity before gestation, family history of type-2 diabetes, low birth weight of mother, age, increased fasting plasma level of triglyceride, as well as parents' history of type-2 diabetes, all were risk factors for GDM. Physical exercise was found to be a protective factor for GDM. Mother's history of type-2 diabetes did not differ from father's in contributing to the onset of GDM in their offspring.
Ouyang
Fengxiu
F
Department of Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China.
Shen
Fumin
F
Jiang
Feng
F
Hu
Haiqin
H
Pan
Mingming
M
D000328:Adult; D001724:Birth Weight; D003920:Diabetes Mellitus / Q000235:genetics; D016640:Diabetes, Gestational / Q000209:etiology*; D015444:Exercise; D005260:Female; D006801:Humans; D016015:Logistic Models; D009765:Obesity / Q000150:complications; D011247:Pregnancy; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides