title: Visualization of ischaemic penumbra using a computed tomography perfusion method.
abstract: A computed tomography (CT) perfusion imaging and a diffusion/perfusion magnetic resonance imaging (MRI) were performed in a 51-year-old man at 15 and 15.5 h of onset of left middle cerebral artery infarction, respectively. The established infarct, as revealed by the diffusion-weighted MRI, had low values of cerebral blood flow (CBF) and cerebral blood volume (CBV) on the CT perfusion study. The ischaemic penumbra, as reflected by the perfusion-diffusion mismatch on MRI, had reduced CBF, prolonged mean transit time (MTT) and compensated CBV. Spontaneous bleeding occurred in the medial part of the left lentiform nucleus, immediately following decompressive craniectomy. CT measurements of CBF, CBV and MTT may visualize the ischaemic penumbra and explain the site of bleeding after surgical decompression.
authors.affiliation: University Department of Medicine, Queen Mary Hospital, Hong Kong. rtcheung@hkucc.hku.hk
authors.forename: R T F
authors.initials: RT
authors.lastname: Cheung
authors.forename: Pui W
authors.initials: PW
authors.lastname: Cheng
authors.forename: Wai  M
authors.initials: W
authors.lastname: Lui
authors.forename: Gilberto K T
authors.initials: GK
authors.lastname: Leung
authors.forename: Ting-Yim
authors.initials: TY
authors.lastname: Lee
mesh_terms: D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002560:Cerebrovascular Circulation; D003399:Craniotomy; D004058:Diffusion; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010477:Perfusion; D014057:Tomography, X-Ray Computed / Q000379:methods*