Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes.
T cells may recognize glycolipids and lipids of bacterial and self origin associated with the CD1 antigen-presenting molecules. Understanding the mechanisms governing CD1-self glycolipid interaction will provide information on the molecular rules of glycolipid presentation and suggest new approaches to immunotherapy.
De Libero
Gennaro
G
Experimental Immunology, Department of Research, University Hospital, Basel, CH-4031 Basel, Switzerland.
Mori
Lucia
L
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D018949:Antigens, CD1 / Q000235:genetics / Q000276:immunology; D001324:Autoantigens / Q000276:immunology / Q000502:physiology*; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology / Q000502:physiology*; D006028:Glycosphingolipids / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007167:Immunotherapy; D008958:Models, Molecular; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D018949:Antigens, CD1; D001324:Autoantigens; D006028:Glycosphingolipids