title: Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
abstract: To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.
authors.affiliation: Department of Pediatrics, Vrije Universiteit Medical Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl
authors.forename: Petra J G
authors.initials: PJ
authors.lastname: Zwijnenburg
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: John J
authors.initials: JJ
authors.lastname: Roord
authors.forename: A Marceline
authors.initials: AM
authors.lastname: van Furth
mesh_terms: D000818:Animals; D001769:Blood / Q000382:microbiology; D001921:Brain / Q000276:immunology / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D018925:Chemokines / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005786:Gene Expression Regulation; D016753:Interleukin-10 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D008586:Meningitis, Pneumococcal / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D018925:Chemokines; D016207:Cytokines; D016753:Interleukin-10