title: [Role of missense mutation (M235T) in the angiotensinogen gene in development of cerebral ischemia].
abstract: Possible correlation of M/T polymorphism of angiotensinogen gene with risk of ischemic stroke and basic risk factors of cerebral pathology (levels of arterial pressure and blood cholesterol; presence of diabetes mellitus, coronary heart disease, or myocardial infarction in anamnesis; and stenosis of major cerebral arteries) was studied. It was shown that M/T polymorphic variants of angiotensinogen gene were factors determining neither clinical variant of cerebral ischemia development (acute ischemic stroke or chronic brain ischemia) nor formation of main risk factors of stroke.
authors.affiliation: Department of Basic and Clinical Neurology, Russian State Medical University, Moscow.
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Kol'tsova
authors.forename: T I
authors.initials: TI
authors.lastname: Tupitsyna
authors.forename: O V
authors.initials: OV
authors.lastname: Miloserdova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Botsina
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D011110:Polymorphism, Genetic
chemical_list: D000808:Angiotensinogen