Rotary protein motors.
Three protein motors have been unambiguously identified as rotary engines: the bacterial flagellar motor and the two motors that constitute ATP synthase (F(0)F(1) ATPase). Of these, the bacterial flagellar motor and F(0) motors derive their energy from a transmembrane ion-motive force, whereas the F(1) motor is driven by ATP hydrolysis. Here, we review the current understanding of how these protein motors convert their energy supply into a rotary torque.
Oster
George
G
Depts Molecular and Cellular Biology and ESPM, College of Natural Resources, University of California, Berkeley, CA 94720, USA. goster@nature.berkely.edu
Wang
Hongyun
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism* / Q000648:ultrastructure; D004734:Energy Metabolism / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D005407:Flagella / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D020409:Molecular Motor Proteins / Q000378:metabolism* / Q000648:ultrastructure; D011387:Prokaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006180:Proton-Translocating ATPases / Q000378:metabolism* / Q000648:ultrastructure; D013816:Thermodynamics; D019415:Torque
D001426:Bacterial Proteins; D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases