Current intracerebral haemorrhage management.
Primary intracerebral haemorrhage (ICH) refers to spontaneous bleeding from intraparenchymal vessels. It accounts for 10-20% of all strokes, with higher incidence rates amongst African and Asian populations. The major risk factors are hypertension and age. In addition to focal neurological findings, patients may present with symptoms of elevated intracranial pressure. The diagnosis of ICH can only be made through neuro-imaging. A CT scan is presently standard, although MRI is increasingly important in the evaluation of acute cerebrovascular disease. A significant proportion of intracerebral haematomas expand in the first hours post-ictus and this is often associated with clinical worsening. There is evidence that the peri-haematomal region is compromised in ICH. This tissue is oedematous, although the precise pathogenesis is controversial. An association between elevated arterial pressure and haematoma expansion has been reported. Although current guidelines recommend conservative management of arterial pressure in ICH, an acute blood pressure lowering trial is overdue. ICH is associated with a high early mortality rate, although a significant number of survivors make a functional recovery. Current medical management is primarily aimed at prevention of complications including pneumonia and peripheral venous thromboembolism. Elevated intracranial pressure may be treated medically or surgically. Although the latter definitively lowers elevated intracranial pressure, the optimal patient selection criteria are not clear. Aggressive treatment of hypertension is essential in the primary and secondary prevention of ICH.
Butcher
Kenneth
K
Department of Neurosciences, Royal Melbourne Hospital, Melbourne, Australia. k.butcher@mh.org.au
Laidlaw
John
J
D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods; D006470:Hemorrhage / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D020521:Stroke / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome