Anxiety induced by repetitive transcranial magnetic stimulation is suppressed by chronic treatment of paroxetine in rats.
Repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on affective disorder and anxiety disorders. However, some reports have linked rTMS to a significant increase in anxiety in normal volunteers. This study investigates the effect of rTMS on anxiety and the use of acute and chronic paroxetine treatment on this animal model of anxiety. In normal rats, rTMS for 10 days induced anxiety, as shown by elevated plus maze, black and white box, and conditioned fear tests. This anxiety was suppressed by chronic, but not acute, paroxetine. These results suggest that rats receiving chronic rTMS treatment can be used as a model of anxiety and that the anxiety induced by rTMS might involve the serotonergic system.
Isogawa
K
K
Department of Neuropsychiatry, Oita Medical University, Hasama-Machi, Japan.
Fujiki
M
M
Akiyoshi
J
J
Tsutsumi
T
T
Horinouchi
Y
Y
Kodama
K
K
Nagayama
H
H
D000208:Acute Disease; D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D004558:Electric Stimulation; D005239:Fear / Q000187:drug effects; D008297:Male; D018782:Maze Learning; D009043:Motor Activity / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D050781:Transcranial Magnetic Stimulation
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors