Delayed presentation of calcium channel antagonist overdose.
The calcium channel antagonists are generally safe in therapeutic dosage, but severe side effects with elevated intake are increasingly described. Typical features include confusion, lethargy, hypotension, sinus node depression, and cardiac conduction defects. Even if patients are stable on presentation, this does not preclude the possible late development of adverse events from the long-acting formulations of calcium channel blockers. A case of toxic overdose with 1440 mg of slow-release diltiazem is presented; this patient was stable on presentation, but rapidly became hemodynamically unstable, requiring treatment with intravenous calcium, temporary pacemaker, inotropic support and mechanical ventilation with a successful outcome. A concise review of the therapeutic considerations is provided.
Punukollu
Gopikrishna
G
Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA.
Gowda
Ramesh M
RM
Khan
Ijaz A
IA
Dogan
Ozgen M
OM
D001919:Bradycardia / Q000139:chemically induced / Q000628:therapy; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D002125:Calcium Gluconate / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000628:therapy; D000860:Hypoxia / Q000139:chemically induced / Q000628:therapy; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004110:Diltiazem; D002125:Calcium Gluconate