title: Analysing neuronal correlates of the comparison of two sequentially presented sensory stimuli.
abstract: In a typical sequential sensory discrimination task, subjects are required to make a decision based on comparing a sensory stimulus against the memory trace left by a previous stimulus. What is the neuronal substrate for such comparisons and the resulting decisions? This question was studied by recording neuronal responses in a variety of cortical areas of awake monkeys (Macaca mulatta), trained to carry out a vibrotactile sequential discrimination task. We describe methods to analyse responses obtained during the comparison and decision phases of the task, and describe the resulting findings from recordings in secondary somatosensory cortical area (S2). A subset of neurons in S2 become highly correlated with the monkey's decision in the task.
authors.affiliation: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. brody@cshl.org
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Brody
authors.forename: Adrián
authors.initials: A
authors.lastname: Hernández
authors.forename: Antonio
authors.initials: A
authors.lastname: Zainos
authors.forename: Luis
authors.initials: L
authors.lastname: Lemus
authors.forename: Ranulfo
authors.initials: R
authors.lastname: Romo
mesh_terms: D000818:Animals; D003657:Decision Making / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D008253:Macaca mulatta; D009474:Neurons / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*