title: Changes in intraocular pressure and pupil size following intramuscular administration of hydromorphone hydrochloride and acepromazine in clinically normal dogs.
abstract: OBJECTIVE
  To investigate the effects of intramuscularly administered hydromorphone hydrochloride and acepromazine on intraocular pressure (IOP) and pupil size (PS).
  
  
  METHODS
  Seventeen dogs free of clinically relevant ocular abnormalities.
  
  
  METHODS
  Measurements of IOP and PS were obtained and the dogs were injected intramuscularly with hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg). Measurements of IOP and PS were repeated 10 min and 25 min later.
  
  
  RESULTS
  Though a decreasing trend in IOP values was demonstrated, no significant difference was noted in IOP from the initial examination to examination following intramuscular administration of hydromorphone and acepromazine. Significant miosis was present in 16 of 17 dogs at 10 min and 25 min following administration of hydromorphone and acepromazine.
  
  
  CONCLUSIONS
  Hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg) cause significant miosis in dogs at 10 and 25 min following intramuscular administration.
authors.affiliation: Indianapolis Veterinary Specialists, 8250 Bash Street, Indianapolis, IN 46250, USA. jstephan@sprynet.com
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Stephan
authors.forename: W A
authors.initials: WA
authors.lastname: Vestre
authors.forename: Jean
authors.initials: J
authors.lastname: Stiles
authors.forename: Sheryl
authors.initials: S
authors.lastname: Krohne
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001947:Breeding; D004285:Dogs / Q000502:physiology*; D005260:Female; D004091:Hydromorphone / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular / Q000662:veterinary; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008916:Miotics / Q000008:administration & dosage / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*; D012016:Reference Values
chemical_list: D000701:Analgesics, Opioid; D008916:Miotics; D000075:Acepromazine; D004091:Hydromorphone