[Inflammation, prelude to renal sclerosis: the importance of NF-kappa B].
NF-kappa B comprises a family of transcription factors. These are thought to have a central role in the expression of genes involved in cell mobilization, cell proliferation and cell differentiation, and, hence, in inflammation, repair and fibrosis processes. In particular, NF-kappa B activation appears to drive a number of inflammatory diseases of the kidney and their progression to end-stage renal failure. Thus, targeting NF-kappa B activation would lead to the development of new pharmaceutical compounds that would provide novel treatment for these diseases.
Baud
Laurent
L
Service d'Explorations Fonctionnelles Multidisciplinaries et Unité INSERM 489, Hôpital Tenon, Paris.
Fouqueray
Bruno
B
Bellocq
Agnès
A
Haymann
Jean-Philippe
JP
Peltier
Julie
J
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D019281:Dimerization; D018450:Disease Progression; D005355:Fibrosis; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism / Q000502:physiology; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000517:prevention & control; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D009393:Nephritis / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D012598:Sclerosis; D014158:Transcription, Genetic / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D000072000:NF-KappaB Inhibitor alpha