title: The Southeast Collaboratory for Structural Genomics: a high-throughput gene to structure factory.
abstract: The Southeast Collaboratory for Structural Genomics consists of four working groups. The protein production group supplies/develops high-output production of Pyrococcus furiosus, Caenorhabditis elegans, and selected human proteins. The X-ray crystallography group conducts high-throughput structure production in parallel with production-related research/development in nanocrystallization robotics, capillary crystallization cassette, synchrotron/home X-ray instrumentation, sample mounting robotics, data processing and pipelined structure analysis, combined refinement/validation protocols, and direct use of unlabeled native crystals (Direct Crystallography). The NMR group emphasizes/develops sample screening and backbone structure determination from residual dipolar coupling data. The bioinformatics group implements/develops local database interfaces, pipelined sequence/structure information search/updates, and database/bioinformatics toolkits.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA.
authors.forename: Michael W W
authors.initials: MW
authors.lastname: Adams
authors.forename: Harry A
authors.initials: HA
authors.lastname: Dailey
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: DeLucas
authors.forename: Ming
authors.initials: M
authors.lastname: Luo
authors.forename: James H
authors.initials: JH
authors.lastname: Prestegard
authors.forename: John P
authors.initials: JP
authors.lastname: Rose
authors.forename: Bi-Cheng
authors.initials: BC
authors.lastname: Wang
mesh_terms: D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry* / Q000235:genetics; D003299:Cooperative Behavior; D003460:Crystallization; D018360:Crystallography, X-Ray; D001330:Electronic Data Processing; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D020027:Pyrococcus furiosus / Q000235:genetics*; D011994:Recombinant Proteins / Q000737:chemistry* / Q000235:genetics; D012371:Robotics; D015144:Southeastern United States; D014495:Universities
chemical_list: D029742:Caenorhabditis elegans Proteins; D011994:Recombinant Proteins