Functional genomic maps in Caenorhabditis elegans.
The completion of the Caenorhabditis elegans genome sequence was the initial step toward the use of whole-genome analysis in this model organism. Advances in C. elegans genomics include transcript profiling, gene-function screens using RNA-mediated interference, and protein-interaction mapping using the yeast two-hybrid system. Recent reports have employed these methods to gain new insights into diverse biological problems such as tissue-specific gene expression, cell-fate specification, genome organization, the DNA damage response, and early embryonic development. These studies combined genomic approaches to probe complex biological pathways on an unprecedented scale.
Grant
Barth D
BD
Rutgers, State University of New Jersey, Department of Molecular Biology and Biochemistry, 604 Allison Road, Nelson Biological Laboratories, room A307, Piscataway, NJ 08854, USA. grant@biology.rutgers.edu
Wilkinson
Hilary A
HA
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology* / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics*; D002874:Chromosome Mapping; D016172:DNA Fingerprinting; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D015698:Genomic Library; D008954:Models, Biological; D034622:RNA Interference; D020798:Two-Hybrid System Techniques