Effects of stress on the urinary excretory pattern of niacin catabolites, the most reliable index of niacin status, in humans.
Urinary output of water-soluble vitamins has been used as an indices for vitamin nutrition. It has been pointed out that the coefficient variance of these values is high, especially for niacin catabolites. Thus, we investigated what kinds of stress affect the catabolism using female subjects. The effects of cold exposure (as a typical physical stress), calculation exercise (a typical mental stress) and dark exposure (a typical emotional stress) on the metabolism of niacin were investigated. Of the stresses, cold exposure significantly increased urinary excretory output of the niacin metabolites. The biosynthesis of nicotinamide from Trp seemed to be increased by cold exposure.
Okamoto
Hidemi
H
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan. hokamoto@shc.usp.ac.jp
Ishikawa
Aya
A
Nishimuta
Mamoru
M
Kodama
Naoko
N
Yoshitake
Yutaka
Y
Fukuwatari
Tsutomu
T
Shibata
Katsumi
K
D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects; D018592:Cross-Over Studies; D003624:Darkness / Q000009:adverse effects; D005260:Female; D006801:Humans; D008606:Mental Processes / Q000502:physiology; D009525:Niacin / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors
D009525:Niacin