title: Severe neutropenia with gelatinous bone marrow transformation in anorexia nervosa: a case report.
abstract: A 28-year-old woman with a history of anorexia nervosa was admitted with excessive weight loss, edema, and amenorrhea. She had lost 34% of her previous body weight within 2 years, and her body mass index was 12.3 kg/m(2). The leukocyte count on admission was 2150/microl and gradually decreased to 980/microl (neutrophils; 276/microl). Bone marrow biopsy disclosed gelatinous transformation with hypocellularity. After the patient was treated with intravenous nutritional support, the severe neutropenia improved to the level on admission. Hematological abnormalities seem to be common in anorexia nervosa, but severe neutropenia with gelatinous bone marrow transformation has rarely been reported.
authors.affiliation: Department of General Internal Medicine, Seirei Hamamatsu General Hospital, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nishio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamada
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamada
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Okabe
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okuya
authors.forename: Osamu
authors.initials: O
authors.lastname: Yonekawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ono
authors.forename: Naohi
authors.initials: N
authors.lastname: Sahara
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Tamashima
authors.forename: Michio
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D001706:Biopsy; D015992:Body Mass Index; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D009503:Neutropenia / Q000209:etiology* / Q000473:pathology; D015431:Weight Loss