title: High tumor necrosis factor-alpha levels in the patients with Epstein-Barr virus-associated peripheral T-cell proliferative disease/lymphoma.
abstract: We have attempted to find out any relationships between circulating tumor necrosis factor (TNF)-alpha levels and Epstein-Barr virus (EBV) associated peripheral T-cell and NK-cell proliferative disease/lymphoma (PTPD/L) status. The distribution of TNF-alpha level was significantly higher (P<0.05) in patients than in controls. Patients carrying EBV genome in their peripheral T-cells showed higher TNF-alpha levels than the patients with EBV negative peripheral T-cells (P<0.001). Among patients whose peripheral T-cells were positive for EBV genome, TNF-alpha levels between the wild type LMP-1 gene carriers and the 30-bp deletion type LMP-1 gene carriers were compared and the wild type LMP-1 gene carrier group showed significantly higher TNF-alpha levels (P<0.01). As for the outcome of the patients and TNF-alpha levels, significant differences were observed between dead and alive with disease group (P<0.001), and dead and alive with complete remission group (P<0.01). Since circulating TNF-alpha levels in PTPD/L patients correlate with the disease and EBV infection status, it may be possible that monitoring of the TNF-alpha levels will be a useful prognostic marker.
authors.affiliation: Department of Biological Sciences, School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Atsumi
authors.initials: A
authors.lastname: Mori
authors.forename: Satomi
authors.initials: S
authors.lastname: Takao
authors.forename: Jintana
authors.initials: J
authors.lastname: Pradutkanchana
authors.forename: Suparp
authors.initials: S
authors.lastname: Kietthubthew
authors.forename: Winyou
authors.initials: W
authors.lastname: Mitarnun
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology*; D016411:Lymphoma, T-Cell, Peripheral / Q000097:blood / Q000209:etiology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012074:Remission Induction; D013601:T-Lymphocytes / Q000821:virology*; D013785:Thailand; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014409:Tumor Necrosis Factor-alpha; D014763:Viral Matrix Proteins