Statin therapy and small fibre neuropathy: a serial electrophysiological study.
We describe three patients who developed small fibre neuropathy after 1 month of statin therapy with clinical resolution upon prompt drug withdrawal. All patients showed abnormal sympathetic skin responses (SSR) in comparison with controls. SSRs returned to normal in tandem with clinical improvement. One patient redeveloped small and large fibre neuropathy when the similar drug was readministered. The SSR is of value in the electrophysiological assessment and follow-up of statin-related small fibre neuropathy.
Lo
Y L
YL
Department of Neurology, Singapore General Hospital, Outram Road, Singapore. gnrlyl@sgh.com.sg
Leoh
T H
TH
Loh
L M
LM
Tan
C E
CE
D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004558:Electric Stimulation; D004594:Electrophysiology; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D035002:Lower Extremity / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D017035:Pravastatin / Q000009:adverse effects* / Q000627:therapeutic use; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D019821:Simvastatin; D017035:Pravastatin