title: Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity.
abstract: A novel series of alpha-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.
authors.affiliation: Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Scotland, ML1 5SH, UK. a.cooke@organon.co.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Cooke
authors.forename: Alison
authors.initials: A
authors.lastname: Anderson
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bennett
authors.forename: Kirsteen
authors.initials: K
authors.lastname: Buchanan
authors.forename: David
authors.initials: D
authors.lastname: Gemmell
authors.forename: Niall
authors.initials: N
authors.lastname: Hamilton
authors.forename: Maurice
authors.initials: M
authors.lastname: Maidment
authors.forename: Petula
authors.initials: P
authors.lastname: McPhail
authors.forename: Donald
authors.initials: D
authors.lastname: Stevenson
authors.forename: Hardy
authors.initials: H
authors.lastname: Sundaram
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004952:Esters; D058787:GABA-A Receptor Antagonists; D008297:Male; D051379:Mice; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D018686:Anesthetics, Intravenous; D004952:Esters; D058787:GABA-A Receptor Antagonists; D010636:Phenols; D015742:Propofol