Bacterial siderophores: synthesis and biological activities of novel pyochelin analogues.
The synthesis and biological activities of four pyochelin analogues substituted in different parts of the molecule are reported: 5-NHBoc-pyochelin, 3"N-Boc-pyochelin, 3"-nor-NH-pyochelin and neopyochelin II, the enantiomer of natural pyochelin. All these compounds complex iron(III) and transport it at different rates into the cells of Pseudomonas aeruginosa.
Zamri
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A
Laboratorium Kimia Organik FMIPA-UNRI, Jl Raya Bangkinang Km 12.5, Pekanbaru 28293, Indonesia.
Schalk
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IJ
Pattus
F
F
Abdallah
M A
MA
D007202:Indicators and Reagents; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D017262:Siderophores / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles
D007202:Indicators and Reagents; D007502:Iron Chelating Agents; D010636:Phenols; D017262:Siderophores; D013844:Thiazoles; C025316:pyochelin; D007501:Iron