The nitric oxide-endothelin-1 connection.
Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.
Alonso
David
D
Department of Integrative Biology and Pharmacology, University of Texas-Houston, 77030, USA.
Radomski
Marek W
MW
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology* / Q000627:therapeutic use; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin / Q000627:therapeutic use; D014661:Vasoconstriction / Q000502:physiology
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin; D009569:Nitric Oxide