title: Morphological changes of parotid glands following adjuvant arthritis and ibuprofen treatment in rats.
abstract: Drug administration and numerous systemic diseases may cause morphological changes of the parotid gland. The aim of this study was to investigate the possible relationship between experimental adjuvant arthritis following ibuprofen treatment and morphological alterations of the parotid glands in rats. Freud's adjuvant was injected intradermally into the plantar surface of the hind paw of the animals to induce experimental arthritis. Ibuprofen was administrated per os (17 mg/kg/day). Both adrenals and parotid glands were isolated and their absolute and relative weights were evaluated. A full histological examination of parotid glands took place. The diameter of the foot as well as the serum levels of rheumatoid factor was measured. In conclusion, both experimental adjuvant arthritis and ibuprofen treatment induce morphological changes of the parotid tissues, which are related to macro- and micro-structure of the gland.
authors.affiliation: Division of Oral Therapeutics, Department of Pharmacology, Medical School, University of Athens, M. Asias 75, Goudi 11527, Athens, Greece. mourior1@otenet.gr
authors.forename: C
authors.initials: C
authors.lastname: Mourouzis
authors.forename: T
authors.initials: T
authors.lastname: Saranteas
authors.forename: M
authors.initials: M
authors.lastname: Tsamouris
authors.forename: C
authors.initials: C
authors.lastname: Tesseromatis
mesh_terms: D000276:Adjuvants, Immunologic; D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology*; D001284:Atrophy; D005355:Fibrosis; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size; D010306:Parotid Gland / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D010309:Parotitis / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012217:Rheumatoid Factor / Q000097:blood; D018987:Salivary Ducts / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013223:Statistics as Topic
chemical_list: D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012217:Rheumatoid Factor; D007052:Ibuprofen