The impact of left ventricular dysfunction on cardiac donor transplant rates.
BACKGROUND
Because of the shortage of heart donors in the United States, efforts are necessary to maximize the yield of donor screening. The purpose of this study was to quantify the effects of left ventricular (LV) systolic dysfunction on heart donor use.


METHODS
Using the California Transplant Donor Network database, the records of all potential organ donors screened between January 1997 and June 1998 were reviewed. After excluding subjects for whom family consent could not be obtained and subjects <13 or >or=60 years old, a study group of 223 potential heart donors was analyzed. The number of hearts not used because of LV dysfunction, coronary artery disease (CAD), valvular disease, and LV hypertrophy were quantified. A logistic regression model was developed to quantify the independent effect of LV dysfunction on donor use rates after adjustment for age, weight, and cause of death.


RESULTS
Ninety-nine (44%) of the 223 potential donor hearts were not transplanted. Thirty-six of these hearts were not transplanted because of cardiac causes, primarily LV dysfunction (26 cases) and CAD (8 cases). The multivariable analysis showed that after adjusting for other donor variables, ejection fraction was the most significant predictor of non-use, with an odds ratio of 1.48 per 5-point decrease in ejection fraction.


CONCLUSIONS
Left ventricular dysfunction is an important cause of failure to transplant adult donor hearts. Efforts to improve the yield of heart donor screening should focus on prevention or reversal of LV dysfunction.
Zaroff
Jonathan G
JG
Department of Medicine, University of California, San Francisco California 94143-0124, USA. zaroff@medicine.ucsf.edu
Babcock
Wayne D
WD
Shiboski
Stephen C
SC
D000328:Adult; D016208:Databases, Factual; D016027:Heart Transplantation; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D012189:Retrospective Studies; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D018487:Ventricular Dysfunction, Left