title: Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland.
abstract: Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells. No staining was found in the pancreas, which is in contrast to what has been described in the human.
authors.affiliation: Department of Physiology, Division of Comparative Medicine, Uppsala University, BMC Box 570, 75123 Uppsala, Sweden.
authors.forename: G Persdotter
authors.initials: GP
authors.lastname: Hedlund
authors.forename: H E
authors.initials: HE
authors.lastname: Carlsson
authors.forename: E
authors.initials: E
authors.lastname: Shieck
authors.forename: I
authors.initials: I
authors.lastname: Nilsson
authors.forename: C
authors.initials: C
authors.lastname: Lundblad
authors.forename: S
authors.initials: S
authors.lastname: Arons
authors.forename: A K
authors.initials: AK
authors.lastname: Iversen
authors.forename: C
authors.initials: C
authors.lastname: Looman
authors.forename: H E
authors.initials: HE
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Hau
mesh_terms: D000311:Adrenal Glands / Q000737:chemistry* / Q000166:cytology; D000367:Age Factors; D000818:Animals; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D013006:Growth Hormone / Q000494:pharmacology; D015918:Infusion Pumps, Implantable; D010053:Ovary / Q000737:chemistry* / Q000166:cytology; D010902:Pituitary Gland / Q000737:chemistry* / Q000166:cytology; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006023:Glycoproteins; D011388:Prolactin; D013006:Growth Hormone