IL-10, an inflammatory/inhibitory cytokine, but not always.
IL-10 has been previously called cytokine synthesis inhibiting factor, produced mostly by Th2 cells, macrophages and CD8+ cell clones. IL-10 is capable of inhibiting the synthesis of several cytokines from different cells, antigen or mitogen activated. IL-10 exerts its inhibition at the mRNA transcriptional and translational level. In addition, IL-10 is a co-stimulatory cytokine on activated T cells. For example, IL-10 inhibits NK cell activity, the production of Th1 cytokines, cytokines generated by peripheral blood mononuclear cells, and macrophage activity. On the other hand, IL-10 exerts immunostimulatory effects on B cells, cytotoxic T cell development and thymocytes. In mast cells derived from CD4+/CD133+ cells, IL-10 inhibits IL-6 and TNFalpha, and prostaglandin E(1) and E(2) induced by IL-6. Here, we report for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 (HMC-1) and human umbilical cord blood-derived mast cells.
Conti
Pio
P
Immunology Division, University of Chieti, School of Medicine, Chieti, Italy. pconti@unich.it
Kempuraj
Duraisamy
D
Kandere
Kristiana
K
Di Gioacchino
Mario
M
Barbacane
Renato C
RC
Castellani
Maria L
ML
Felaco
Mario
M
Boucher
William
W
Letourneau
Richard
R
Theoharides
Theoharis C
TC
D006801:Humans; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000502:physiology*; D008407:Mast Cells / Q000276:immunology / Q000648:ultrastructure; D018448:Models, Immunological
D016753:Interleukin-10