title: Alpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese.
abstract: Several polymorphisms of genes involved in autonomic nervous system (ANS) function have been reported to affect metabolic regulation. We have investigated the association of an alpha(2B)-adrenergic receptor (alpha(2B)AR) three-amino acid deletion polymorphism with ANS activity in young healthy subjects by means of electrocardiogram R-R interval power spectral analysis. Three hundred eighty-one young healthy Japanese males (mean +/- SE, 20.6 +/- 0.1 yr) were studied. One hundred sixty-eight (44.1%) were homozygotes of Long allele (Long/Long), 162 (42.5%) were heterozygotes (Long/Short), and 51 (13.4%) were homozygotes of Short allele (Short/Short). The allele frequency of Short allele was 0.35. No significant differences were observed in any of the characteristics investigated: body mass index, plasma glucose, plasma insulin, or family history of diabetes and obesity. In R-R spectral analysis of heart rate variability, carriers of Short/Short had significantly greater low frequency and very low frequency than Long/Long, as well as a higher sympathetic nervous system index. These findings suggest that the alpha(2B)AR deletion polymorphism might result in metabolic disorder by altering ANS function.
authors.affiliation: Laboratories of Metabolism, Kyoto University Graduate School of Human and Environmental Studies, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Suzuki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Kae
authors.initials: K
authors.lastname: Nagasumi
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Yamamura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shihara
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ue
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamon
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
authors.forename: Kinsuke
authors.initials: K
authors.lastname: Tsuda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001481:Basal Metabolism; D015992:Body Mass Index; D004562:Electrocardiography; D017353:Gene Deletion; D006801:Humans; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
chemical_list: C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2