title: Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.
abstract: Inhibition of human cytomegalovirus (HCMV) by 1263W94 was additive dosewise in combination with ganciclovir, acyclovir, and foscarnet. None of the commonly used anti-human immunodeficiency virus agents antagonized the inhibition of HCMV by 1263W94. The data were analyzed by a modified isobologram procedure that measures the strength and statistical significance of drug interactions.
authors.affiliation: GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. dean.w.selleseth@gsk.com
authors.forename: Dean W
authors.initials: DW
authors.lastname: Selleseth
authors.forename: Christine L
authors.initials: CL
authors.lastname: Talarico
authors.forename: Teresa
authors.initials: T
authors.lastname: Miller
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lutz
authors.forename: Karen K
authors.initials: KK
authors.lastname: Biron
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Harvey
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D012263:Ribonucleosides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D012263:Ribonucleosides; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole