title: Antibiotic therapy after acute myocardial infarction: a prospective randomized study.
abstract: BACKGROUND
  Infection with Chlamydia pneumoniae is suspected to contribute to the pathogenesis of human atherosclerosis. We investigated whether treatment with the macrolide antibiotic roxithromycin would reduce mortality or morbidity in patients with an acute myocardial infarction.
  
  
  RESULTS
  Eight hundred seventy-two patients with an acute myocardial infarction (AMI) were randomly assigned to receive double-blind treatment with either 300 mg roxithromycin or placebo daily for 6 weeks. Primary end point was total mortality during 12-month follow-up. Four hundred thirty-three patients were treated with roxithromycin and 439 with placebo. With the exception of a higher proportion of patients suffering an anterior wall AMI (48.1% in the roxithromycin group versus 40.2% in the placebo group; P=0.027) and a lower prevalence of chronic obstructive pulmonary disease in the roxithromycin group (3.5% versus 6.9%, P=0.028), baseline characteristics, reperfusion therapy, and medical treatment were well balanced between the two groups. More patients in the roxithromycin group interrupted their study medication before completion of at least 4 weeks of treatment (78 of 433 [18%] versus 48 of 439 [11%]; P=0.003; odds ratio, 1.8; 95% CI, 1.2 to 2.6). Follow-up at 12 months was achieved in 868 of 872 (99.5%) patients. Total mortality at 12 months was 6.5% (28 of 431) in the roxithromycin group compared with 6.0% (26 of 437) in the placebo group (odds ratio, 1.1; 95% CI, 0.6 to 1.9; P=0.739). There were also no differences in the secondary combined end points at 12 months.
  
  
  CONCLUSIONS
  Treatment of AMI patients with roxithromycin did not reduce event rates during 12 months of follow-up. Therefore, our findings do not support the routine use of antibiotic treatment with a macrolide in patients with AMI.
authors.affiliation: Kardiologie, Herzzentrum Ludwigshafen, Germany. erzahn@aol.com
authors.forename: Ralf
authors.initials: R
authors.lastname: Zahn
authors.forename: Steffen
authors.initials: S
authors.lastname: Schneider
authors.forename: Birgit
authors.initials: B
authors.lastname: Frilling
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Seidl
authors.forename: Ulrich
authors.initials: U
authors.lastname: Tebbe
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.forename: Martin
authors.initials: M
authors.lastname: Gottwik
authors.forename: Ernst
authors.initials: E
authors.lastname: Altmann
authors.forename: Friedrich
authors.initials: F
authors.lastname: Seidel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rox
authors.forename: Ulrich
authors.initials: U
authors.lastname: Höffler
authors.forename: Karl-Ludwig
authors.initials: KL
authors.lastname: Neuhaus
authors.forename: Jochen
authors.initials: J
authors.lastname: Senges
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000382:microbiology / Q000517:prevention & control; D023521:Chlamydophila Infections / Q000517:prevention & control; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D015575:Roxithromycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D015575:Roxithromycin