[Morphological and functional changes of tissue receptors of an organ plexus under the effect of blockers of cytoskeleton assembly].
Colchicine and cytochalasine C exert modifying action on tissue receptors of urinary bladder of the frog. Under the effect of cytochalasine the period of vital staining of receptors were changed. Latent period of decoloration grew 37-56% longer while the period of staining accumulation grows 18% shorter. The forming of granules was also altered 2 types of terminal plaques were distinguished according to this sign in the course of treatment with colchicine and 3 types in the experiment with cytochalasine. Modifying action of cytochalasine was greater. Cytochalasin caused mass appearance of round intensely stained plaque the appearance of which was obviously connected with microtubules destruction. Mean area of terminals profile field also increased. Spontaneous impulse activity of receptors was significantly suppressed. Specificity of responses to colchicine and cytochalasine was probably conditioned by their effect on different elements of cytoskeleton.
Lukashin
V G
VG
Laboratory of Neuron Functional Morphology and Physiology, I.P. Pavlov Institute of Physiology, RAS, St. Petersburg.
Zamuraev
I N
IN
D000200:Action Potentials; D000818:Animals; D001001:Anura; D003078:Colchicine / Q000494:pharmacology*; D003572:Cytochalasins / Q000494:pharmacology*; D003599:Cytoskeleton / Q000187:drug effects* / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation* / Q000502:physiology / Q000648:ultrastructure
D003572:Cytochalasins; C031582:cytochalasin C; D003078:Colchicine