Reiter's syndrome associated with HLA-B51: a case report.
A 32-year-old Japanese man developed polyarthritis with mild fever and conjunctivitis. Clinical assessment indicated non-specific arthritis, aseptic pyuria induced by infection with Chlamydia, and conjunctivitis. He was diagnosed with reactive arthritis (Reiter's syndrome). Serotyping of human leucocyte antigen (HLA) class I and II revealed positivity for B51(5), A2, A33(19), B44(12), Cw1, DR4 and DR6, but B27 was negative. He was treated with a combination of doxycycline, oral prednisolone, diclofenac sodium and salazosulphapyridine. Fever and arthralgia improved and he became negative for anti-Chlamydia immunoglobulin (Ig) A and IgG antibodies. HLA-B51 may be involved in the pathogenesis of Reiter's syndrome in this Japanese patient.
Taniguchi
Y
Y
Division of Blood Purification, Hiroshima University Hospital, Hiroshima, Japan.
Yorioka
N
N
Kyuden
Y
Y
Asakimori
Y
Y
D000328:Adult; D016918:Arthritis, Reactive / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D004008:Diclofenac / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D015235:HLA-B Antigens / Q000276:immunology*; D059949:HLA-B51 Antigen; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012460:Sulfasalazine / Q000627:therapeutic use
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D004008:Diclofenac; D012460:Sulfasalazine; D011239:Prednisolone; D004318:Doxycycline