In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis.
Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis.
Tapondjou
L A
LA
Department of Chemistry, Faculty of Science, University of Dschang, box, 183, Dschang, Cameroon.
Lontsi
David
D
Sondengam
Beibam Luc
BL
Choi
Jongwon
J
Lee
Kyung-Tae
KT
Jung
Hyun-Ju
HJ
Park
Hee-Juhn
HJ
D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D027481:Araliaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D007723:Korea; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000097245:Ursolic Acid
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid; C469884:23-hydroxyursolic acid