Spectrophotometric determination of binary mixtures of pseudoephedrine with some histamine H1-receptor antagonists using derivative ratio spectrum method.
A derivative spectrophotometric method is developed for the assay of three binary mixtures of pseudoephedrine with fexofenadine (mix I), cetirizine (mix II) and loratadine (mix III). The method is based on the use of the first derivative of the ratio spectrum. The ratio spectrum was obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other component was determined from its respective calibration graph treated similarly. Moreover, the influence of Deltalambda for obtaining the first derivative of the ratio spectra and the effect of the divisor concentration on the calibration graphs were studied. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
Mahgoub
Hoda
H
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, EL-Messalah, Egypt. pharmacy_alex@hotmail.com
Gazy
Azza A
AA
El-Yazbi
Fawzi A
FA
El-Sayed
Mahmoud A
MA
Youssef
Rasha M
RM
D002626:Chemistry, Pharmaceutical; D004809:Ephedrine / Q000032:analysis*; D006634:Histamine H1 Antagonists / Q000032:analysis*; D019999:Pharmaceutical Solutions / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D006634:Histamine H1 Antagonists; D019999:Pharmaceutical Solutions; D004809:Ephedrine