title: Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain.
abstract: The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens.
authors.affiliation: Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA. elkins@cber.fda.gov
authors.forename: Karen L
authors.initials: KL
authors.lastname: Elkins
authors.forename: Siobhán C
authors.initials: SC
authors.lastname: Cowley
authors.forename: Catharine M
authors.initials: CM
authors.lastname: Bosio
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005604:Francisella tularensis / Q000276:immunology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D014406:Tularemia / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated