title: Osteoporosis: pathogenesis and clinical intervention.
abstract: Osteoporosis is a very common disorder and much has been learnt in recent years about the many pathogenic processes that contribute to bone loss and fragility. Drug treatments are now available to prevent bone loss and reduce fracture, and there are prospects for modifying some of the pathogenic processes themselves. In common with other structures, the tissues of the musculoskeletal system undergo many changes with aging, and some of the commonest skeletal disorders are seen in the elderly. The changes in bone lead to osteoporosis and fractures, whereas muscle changes (sarcopenia) contribute to frailty, and changes in cartilage lead to osteoarthritis.
authors.affiliation: The Botnar Research Centre and Oxford University Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Mueller
authors.forename: R G G
authors.initials: RG
authors.lastname: Russell
mesh_terms: D000375:Aging; D016723:Bone Remodeling; D020022:Genetic Predisposition to Disease; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*