title: Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.
abstract: The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.
authors.affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Sallie R
authors.initials: SR
authors.lastname: Permar
authors.forename: Sherry A
authors.initials: SA
authors.lastname: Klumpp
authors.forename: Keith G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: Woong-Ki
authors.initials: WK
authors.lastname: Kim
authors.forename: Darci A
authors.initials: DA
authors.lastname: Gorgone
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lifton
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Williams
authors.forename: Jörn E
authors.initials: JE
authors.lastname: Schmitz
authors.forename: Keith A
authors.initials: KA
authors.lastname: Reimann
authors.forename: Michael K
authors.initials: MK
authors.lastname: Axthelm
authors.forename: Fernando P
authors.initials: FP
authors.lastname: Polack
authors.forename: Diane E
authors.initials: DE
authors.lastname: Griffin
authors.forename: Norman L
authors.initials: NL
authors.lastname: Letvin
mesh_terms: D000818:Animals; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007111:Immunity, Cellular; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D008457:Measles / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication / Q000276:immunology
chemical_list: D004279:DNA, Viral; D008458:Measles Vaccine; D012367:RNA, Viral