title: Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures.
abstract: We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.
authors.affiliation: Felsenstein Medical Research Cente, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Yuhas
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004405:Dysentery, Bacillary / Q000150:complications*; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D012640:Seizures / Q000209:etiology* / Q000517:prevention & control*; D012762:Shigella dysenteriae / Q000472:pathogenicity*; D013010:Sonication; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology* / Q000502:physiology*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D010433:Pentylenetetrazole