Highly efficient 1,4-addition of 1,3-diesters to conjugated enones by In/TMSCl.
Organoindium reagents derived from indium and diethyl bromomalonates were added to a wide range of conjugated enones in a 1,4-fashion in the presence of TMSCl under mild conditions, and corresponding oxo-1,3-diesters were obtained in good to excellent yields.
Lee
Phil Ho
PH
Department of Chemistry, Kangwon National University, Chunchon 200-701, Republic of Korea. phlee@kangwon.ac.kr
Seomoon
Dong
D
Lee
Kooyeon
K
Heo
Yunkiu
Y