Emerging paradigms for understanding fatness and diabetes risk.
It is widely accepted that increasing adiposity is associated with insulin resistance and increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the portal/visceral hypothesis. This hypothesis proposes that increased adiposity, particularly in the visceral depots, leads to increased free fatty acid flux and inhibition of insulin action via Randle's effect in insulin-sensitive tissues. Recent data do not entirely support this hypothesis. As such, two new paradigms have emerged that may explain the established links between adiposity and disease.
Smith
Steven R
SR
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA. smithsr@pbrc.edu
Ravussin
Eric
E
D003920:Diabetes Mellitus / Q000209:etiology*; D006801:Humans; D008954:Models, Biological; D009765:Obesity / Q000150:complications*; D012307:Risk Factors