An array of insights: application of DNA chip technology in the study of cell biology.
The advent of DNA microarray technology has ushered in an era of systems biology whereby researchers can study the transcriptional behavior of thousands of genes in parallel. Advances in manufacturing techniques and informatics, and the availability of several genome sequences have furthered these capabilities to the point where whole-transcriptome studies can be accomplished in yeast, flies and plants, and soon will be possible in mammals. Concomitant with the expanding ability of the technology has been the development of novel techniques and their application towards the study of cellular biology.
Panda
Satchidananda
S
The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
Sato
Trey K
TK
Hampton
Garret M
GM
Hogenesch
John B
JB
D000818:Animals; D004247:DNA / Q000032:analysis*; D005786:Gene Expression Regulation / Q000235:genetics; D015698:Genomic Library; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology / Q000295:instrumentation* / Q000639:trends*; D009369:Neoplasms / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000639:trends*; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D004247:DNA