B-cell leukemia in a sheep.
Necropsy examination was performed on an 8.5-year-old Finnish ewe euthanatized because of progressive respiratory distress, cachexia, and weakness. Significant postmortem findings included a diffusely enlarged, dark-red friable liver, mild splenomegaly, and mild mesenteric lymphadenopathy. Examination of multiple tissue sections revealed intravascular atypical mononuclear cells in all tissues examined, with a leukemic pattern of infiltration of mesenteric lymph nodes, liver, lung, and spleen. Neoplastic cells were positive for CD79a and negative for CD-3, BLA.36, and CD68 leukocytic markers. The final diagnosis was B-cell leukemia.
Valentine
B A
BA
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA. beth.valentine@orst.edu
McDonough
S P
SP
D000818:Animals; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D015448:Leukemia, B-Cell / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D013154:Spleen / Q000473:pathology