title: Ten-year echocardiographic and clinical follow-up of aortic Carpentier-Edwards pericardial and supraannular prosthesis: a case-match study.
abstract: BACKGROUND
  There are little comparative data on Carpentier-Edwards supraannular and pericardial second-generation bioprostheses. The aim of this work was to compare their hemodynamic and clinical outcomes in patients with aortic stenosis.
  
  
  METHODS
  We conducted a retrospective study including 150 patients operated on for aortic stenosis between 1989 and 1993. Patients undergoing aortic valve replacement with either a Carpentier-Edwards supraannular or pericardial prosthesis were matched for sex (49% male), age (72 +/- 8 years), body surface area, valve size, associated procedures, and left ventricular ejection fraction.
  
  
  RESULTS
  Mean follow-up was 6.5 +/- 3.3 years, giving a total follow-up of 983 patient-years. Thirty-day mortality and 10-year actuarial survival were, respectively, 8% and 51% in the supraannular group and 6.7% and 43.4% in the pericardial group. At 10 years, freedom from thromboembolism, structural failure, and all valve-related events were, respectively, 88.7%, 88.9%, and 68.7% in the supraannular group and 85%, 100%, and 82.2% in the pericardial group. There were four (5.3%) structural failures, and four (5.3%) reoperations for degeneration (n = 3) and endocarditis (n = 1) in the supraannular group. Freedom from structural dysfunction or reoperation was 87.3% in the supraannular group and 100% (p < 0.05) in the pericardial group. Echocardiographic review of 62 of 76 survivors (81.5%) demonstrated a trend toward a better hemodynamic profile of pericardial valves at the end of follow-up.
  
  
  CONCLUSIONS
  Ten years after aortic valve replacement for aortic stenosis, Carpentier-Edwards pericardial prostheses give comparable and probably better results than Carpentier-Edwards supraannular prostheses.
authors.affiliation: Department of Echocardiography, Hôpital Cardiologique, Centre Hôpitalier Régional et Universitaire de Lille, Lille, France. thletourneau@yahoo.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Le Tourneau
authors.forename: André
authors.initials: A
authors.lastname: Vincentelli
authors.forename: Georges
authors.initials: G
authors.lastname: Fayad
authors.forename: Christine
authors.initials: C
authors.lastname: Savoye
authors.forename: Olivier H
authors.initials: OH
authors.lastname: Fabre
authors.forename: Alain
authors.initials: A
authors.lastname: Prat
authors.forename: Henri
authors.initials: H
authors.lastname: Warembourg
mesh_terms: D000368:Aged; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001705:Bioprosthesis; D001830:Body Surface Area; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D010496:Pericardium; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D013318:Stroke Volume