Preparation of potential inhibitors of the mur-pathway enzymes on solid support using an acetal linker.
Here, we report a novel strategy for the combinatorial or parallel solid-phase synthesis of potential inhibitors of the mur-pathway enzymes. The strategy involves the efficient use of p-alkoxybenzylidene acetal linker for reversible immobilization of sugar scaffolds to solid phase. This methodology was used to synthesize several glycopeptides on solid phase in good yields.
Maletic
Milana
M
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.
Antonic
Jelena
J
Leeman
Aaron
A
Santorelli
Gina
G
Waddell
Sherman
S
D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D009112:Muramic Acids / Q000378:metabolism*; D019151:Peptide Library
D004791:Enzyme Inhibitors; D006020:Glycopeptides; D009112:Muramic Acids; D019151:Peptide Library