Hepatotoxic effect of D-galactosamine and protective role of lipid emulsion.
D-galactosamine is a hepatotoxic agent, which induces diffuse injury of liver tissue followed by the regeneration process. Our data showed a high increase of serum aminotransferases after D-galactosamine administration, which indicates a high extent of liver injury. When lipid emulsion was applied immediately after D-galactosamine, the increase of serum aminotransferases was greatly reduced. In addition, the decrease of the cytochrome c oxidase activity induced by D-galactosamine was not observed after lipid emulsion administration and the increase of total liver oxidative capacity in the regeneration period due to activated mitochondrial biogenesis was accelerated. All these findings indicate a protective effect of lipid emulsion administration against D-galactosamine toxicity.
Ferencíková
R
R
Department of Physiology, Medical Faculty, Charles University, Hradec Kralové, Czech Republic.
Cervinková
Z
Z
Drahota
Z
Z
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004338:Drug Combinations; D003576:Electron Transport Complex IV / Q000378:metabolism; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010743:Phospholipids / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013012:Sorbitol / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism / Q000494:pharmacology*
D004338:Drug Combinations; D010743:Phospholipids; D020011:Protective Agents; D014280:Triglycerides; C008288:Lipofundin; C022834:miglyol 812; D013012:Sorbitol; D005688:Galactosamine; D003576:Electron Transport Complex IV; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase