title: Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice.
abstract: CD4(+) T cells co-expressing CD25 (CD4(+)CD25(+) T cells) have been identified as immunoregulatory suppressors modulating autoimmune response. Beside that, autoimmune response was supposed to be associated with malaria infection. Based on these data, we hypothesised that CD4(+)CD25(+) T cells may influence protective immunity to malaria parasites, while suppressing autoimmune response arising throughout the course of malarial infection. To test this possibility, we evaluated the kinetics of CD4(+)CD25(+) T cells during malaria infection and investigated the influence of CD25 depletion by anti-mouse CD25 monoclonal antibody (PC61) on the infection, using a mouse model of premunition to Plasmodium berghei NK65 malaria. The results showed that, during exacerbation of P. berghei NK65 infection, the proportion of CD4(+)CD25(+) T cells among CD4(+) T cells decreased, although that of CD4(+) T cells increased. CD25 depletion clearly delayed the growth of parasitaemia during parasite challenge, particularly in immunised mice. These findings demonstrated that CD4(+)CD25(+) T cells are able to influence protective immunity underlying premunition to P. berghei NK65 parasites.
authors.affiliation: Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Ton That Ai
authors.initials: TT
authors.lastname: Long
authors.forename: Shusuke
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Shozaburo
authors.initials: S
authors.lastname: Onizuka
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Huaman
authors.forename: Hiroji
authors.initials: H
authors.lastname: Kanbara
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D015551:Autoimmunity; D015704:CD4 Antigens / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D007114:Immunization; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010962:Plasmodium berghei / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D015704:CD4 Antigens; D015375:Receptors, Interleukin-2