The Y chromosome and male fertility and infertility.
Since 1995, thanks to a large number of studies, Y chromosome microdeletion screening has become part of the routine diagnostic work-up of severe male factor infertility. Many initial contradictory issues such as variability in deletion frequency, markers to be tested, presence of deletions in 'fertile' men, and genotype-phenotype correlation has been resolved. Past and present unresolved issues are discussed in this review.
Krausz
Csilla
C
Department of Clinical Physiopathology, University of Florence, Florence, Italy. c.krausz@dfc.unifi.it
Forti
G
G
McElreavey
Ken
K
D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D005298:Fertility / Q000235:genetics*; D005817:Genetic Counseling; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male