title: [Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
abstract: OBJECTIVE
  A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population.
  
  
  METHODS
  A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanish population to estimate its prevalence. Two independently collected samples consisting of 486 subjects (sample 1) and 514 subjects (sample 2) were studied. The Leu7Pro polymorphism was determined.
  
  
  RESULTS
  We found only one individual carrying the Leu7Pro variant (0.1%). The allele frequency of the Pro7 allele was extremely low: 0.005 (95% CI,0.0001-0.0015).
  
  
  CONCLUSIONS
  This low prevalence suggests that the Pro7 allele is not one of the genetic determinant factors affecting obesity, plasma lipids or alcoholism in this population.
authors.affiliation: Unidad de Epidemiología Genética y Molecular, Departamento de Medicina Preventiva y Salud Pública, Universitat de València, València, España. olga.portoles@uv.es
authors.forename: Olga
authors.initials: O
authors.lastname: Portolés
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Sorlí
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: González
authors.forename: Salvador
authors.initials: S
authors.lastname: Ruiz de la Fuente
authors.forename: Judith Begoña
authors.initials: JB
authors.lastname: Ramírez
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007930:Leucine; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D009765:Obesity / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D011392:Proline; D011498:Protein Precursors / Q000235:genetics*; D013030:Spain / Q000453:epidemiology
chemical_list: D008055:Lipids; D009478:Neuropeptide Y; D011498:Protein Precursors; C042084:preproneuropeptide Y; D011392:Proline; D007930:Leucine