Breast cancer metastasis suppressor 1: update.
This article reviews information related to the BRMS1 (BReast Metastasis Suppressor 1) metastasis suppressor gene. BRMS1 was identified by differential display comparing metastasis-suppressed chromosome 11 hybrids with metastatic, parental MDA-MB-435 human breast carcinoma cells. BRMS1 has subsequently been shown to suppress metastasis, but not tumorigenicity of human melanoma cells. The murine version, Brms1, also suppresses metastasis and exhibits a high level of homology to the human gene at the structure, nucleotide and amino acid levels. The mechanisms of action remain to be determined; however, BRMS1 transfectant cells have restored gap junctional intercellular communication. Recent data suggest that BRMS1 is part of the mSin3A histone deacetylase complex.
Meehan
William J
WJ
Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Welch
Danny R
DR
D000818:Animals; D002450:Cell Communication; D017629:Gap Junctions / Q000502:physiology; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D008545:Melanoma / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins; D011506:Proteins / Q000235:genetics*; D012097:Repressor Proteins; D056264:Sin3 Histone Deacetylase and Corepressor Complex; D014407:Tumor Cells, Cultured
C410024:BRMS1 protein, human; D009363:Neoplasm Proteins; D011506:Proteins; D012097:Repressor Proteins; D006655:Histone Deacetylases; D056264:Sin3 Histone Deacetylase and Corepressor Complex