title: Effect of the optic size of a single-piece acrylic intraocular lens on posterior capsule opacification.
abstract: OBJECTIVE
  To investigate the effect of the optic size of an intraocular lens (IOL) with sharp optic edges on posterior capsule opacification (PCO).
  
  
  METHODS
  Nishi Eye Hospital, Osaka, Japan.
  
  
  METHODS
  In 5 rabbits, a single-piece 5.5 mm optic AcrySof IOL (Alcon Laboratories) was implanted in 1 eye and a specially fabricated single-piece 7.0 mm optic AcrySof IOL was implanted in the contralateral eye. Histopathological examinations were performed 3 weeks after surgery.
  
  
  RESULTS
  On posterior views, less PCO was noted with the 5.5 mm optic in all rabbits except 1. Histopathological sections demonstrated adhesion of the anterior and posterior capsules between the haptic and optic and the formation of a sharp capsular bend at the posterior optic edge in 3 eyes with the 5.5 mm optic but in no eye with the 7.0 mm optic. Abundant PCO was noted when a sharp capsular bend had not formed.
  
  
  CONCLUSIONS
  Capsular adhesion is a prerequisite of capsular-bend formation. The sharp optic edge alone does not provide a substantial barrier when a capsular bend is not formed. Bulky haptics such as those of the single-piece AcrySof and large optics may hamper capsular adhesion and bend formation.
authors.affiliation: Nishi Eye Hospital, Osaka, Japan. okihiro@nishi-ganka.or.jp
authors.forename: Okihiro
authors.initials: O
authors.lastname: Nishi
authors.forename: Kayo
authors.initials: K
authors.lastname: Nishi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D002386:Cataract / Q000473:pathology* / Q000517:prevention & control; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D011474:Prosthesis Design; D011817:Rabbits; D000267:Tissue Adhesions
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials