title: Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22).
abstract: We report a t(6;8)(q15;q22) in a patient with myelodysplastic syndrome (MDS) with erythroid hypoplasia. The patient was successfully treated with an immunosuppressive treatment with cyclosporin A, while the translocation was repeatedly detected as the sole anomaly with the percentages of positive cells ranging from 5% to 70%. To our knowledge, the t(6:8) has never been described in MDS.
authors.affiliation: Department of Medicine II, Okayama University Medical School, Okayama 700-8558, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Takata
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Fujii
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Kaneda
authors.forename: Chikamasa
authors.initials: C
authors.lastname: Yoshida
authors.forename: Daigo
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Asakura
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shinagawa
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000368:Aged; D000753:Anemia, Refractory / Q000188:drug therapy* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D020223:Chromosome Painting; D002896:Chromosomes, Human, Pair 6 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D016572:Cyclosporine / Q000627:therapeutic use*; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D014178:Translocation, Genetic
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine