Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast.
In the February 21 issue of Cell, demonstrate that asymmetrical loading of Kar9 onto astral microtubules (MTs) emanating from the bud-ward-directed spindle pole ensures delivery of this spindle pole to the bud. Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud.
Paoletti
Anne
A
Institut Curie, UMR144 du CNRS, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Bornens
Michel
M
D017489:CDC28 Protein Kinase, S cerevisiae / Q000235:genetics / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D004718:Saccharomycetales / Q000166:cytology / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
C110443:KAR9 protein, S cerevisiae; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D017489:CDC28 Protein Kinase, S cerevisiae