title: Facile synthesis of 7-amino-4-carbamoylmethylcoumarin (ACC)-containing solid supports and their corresponding fluorogenic protease substrates.
abstract: The bifunctional fluorophore, 7-amino-4-carbamoylmethylcoumarin (ACC) without any protection groups, was regioselectively attached to different solid supports functionalized with a primary amino group. The resulting resins were used to synthesize fluorogenic protease substrates with high yield and purity.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Dong B
authors.initials: DB
authors.lastname: Li
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002853:Chromatography, Liquid; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D010450:Endopeptidases / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D013058:Mass Spectrometry
chemical_list: C411664:7-amino-4-carbamoylmethylcoumarin; D000596:Amino Acids; D003374:Coumarins; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D010450:Endopeptidases