What evidence implicates airway smooth muscle in the cause of BHR?
Bronchial hyperresponsiveness (BHR), the occurrence of excessive bronchoconstriction in response to relatively small constrictor stimuli, is a cardinal feature of asthma. Here, we consider the role that airway smooth muscle might play in the generation of BHR. The weight of evidence suggests that smooth muscle isolated from asthmatic tissues exhibits normal sensitivity to constrictor agonists when studied during isometric contraction, but the increased muscle mass within asthmatic airways might generate more total force than the lesser amount of muscle found in normal bronchi. Another salient difference between asthmatic and normal individuals lies in the effect of deep inhalation (DI) on bronchoconstriction. DI often substantially reverses induced bronchoconstriction in normals, while it often has much less effect on spontaneous or induced bronchoconstriction in asthmatics. It has been proposed that abnormal dynamic aspects of airway smooth muscle contraction velocity of contraction or plasticity- elasticity balance might underlie the abnormal DI response in asthma. We suggest a speculative model in which abnormally long actin filaments might account for abnormally increased elasticity of contracted airway smooth muscle.
Dulin
Nickolai O
NO
Department of Medicine, University of Chicago, IL, USA.
Fernandes
Darren J
DJ
Dowell
Maria
M
Bellam
Shashi
S
McConville
John
J
Lakser
Oren
O
Mitchell
Richard
R
Camoretti-Mercado
Blanca
B
Kogut
Paul
P
Solway
Julian
J
D000199:Actins / Q000502:physiology; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004548:Elasticity; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D016210:Methacholine Chloride / Q000494:pharmacology; D009130:Muscle, Smooth / Q000503:physiopathology*; D012119:Respiration
D000199:Actins; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D006632:Histamine