title: Cytogenetic and molecular characterization of a de novo 4q24qter duplication and correlation to the associated phenotype.
abstract: We report on a newborn with severe psychomotor retardation, minor anomalies, congenital heart defects, thumb and urogenital abnormalities. Cytogenetic analysis showed a 4q24qter duplication, never described before, as the result of a de novo t(4;14). The extension of the duplicated 4q region was defined by FISH using YAC probes. The breakpoint was localized between 106.3cM (YAC 800f2, D4S1572) and 111 cM (YAC 744e4, D4S1564). Comparing our patient with those previously reported in literature, we observed some features mature frequently reported in these patients: psychomotor retardation, retromicrognathia, low set and/or malformed ears and some more specific traits: congenital cardiac defects, hypoplastic thumb and urogenital abnormalities.
authors.affiliation: Medical Genetic Service, S. Camillo-Forlanini Hospital, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rinaldi
authors.forename: C
authors.initials: C
authors.lastname: De Bernardo
authors.forename: M
authors.initials: M
authors.lastname: Assumma
authors.forename: B
authors.initials: B
authors.lastname: Grammatico
authors.forename: E
authors.initials: E
authors.lastname: Buffone
authors.forename: M
authors.initials: M
authors.lastname: Poscente
authors.forename: P
authors.initials: P
authors.lastname: Grammatico
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D020440:Gene Duplication; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007223:Infant; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D011596:Psychomotor Disorders / Q000473:pathology; D013933:Thumb / Q000002:abnormalities; D014178:Translocation, Genetic; D014564:Urogenital Abnormalities