title: [Platelet adhesion and antioxidant therapy in experimental stress].
abstract: We have investigated the platelet activity, by platelet adhesion index and the end products of lipid peroxidation--MDA. Platelet adhesion index was established using Rovatti's method. Determinations were carried out on experimental model consisting of five groups of white male Wistar rats. In the vitamin E supplemented group, the platelet adhesion index was constantly correlated with MDA level. Thus there is a correlation between the intensity of the oxidative stress and vitamin E supplementation. The imbalance between pro- and antioxdants in experimental stress may enhance the platelet adhesion via arachidonic acid metabolism and endoperoxides formation. Steady administration of vitamin E in the experimental stress, due to its antioxidant properties, causes the progressive decrease of peroxidation and of platelet adhesion.
authors.affiliation: Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: Manuela
authors.initials: M
authors.lastname: Ciocoiu
authors.forename: Magda
authors.initials: M
authors.lastname: Bădescu
authors.forename: Ioana
authors.initials: I
authors.lastname: Păduraru
authors.forename: Veronica
authors.initials: V
authors.lastname: Colev-Luca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D003196:Computer Graphics; D004195:Disease Models, Animal; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy*; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde