title: Simvastatin and markers of endothelial function in patients undergoing continuous ambulatory peritoneal dialysis.
abstract: Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are prone to dyslipidemia and have a high risk of cardiovascular death. The aim of this study was to assess the effects of a 6-month treatment with simvastatin (10 mg at bedtime) on markers of endothelial cell injury in 12 hypercholesterolemic CAPD patients. Cholesterol and low-density lipoprotein cholesterol fell significantly after 1 month of therapy. Simvastatin treatment significantly decreased concentrations of vascular cell adhesion molecule and intracellular adhesion molecule after 3 and 6 months of the therapy, respectively. Thrombomodulin decreased significantly after 6 months of the treatment, whereas von Willebrand's factor, P-selectin and E-selectin remained unaltered during simvastatin therapy. Simvastatin, an effective hypolipemic agent, favorably affects endothelial function and may potentially slow the progression of atherosclerosis and confer protection from thrombotic complications in patients with hypercholesterolemia undergoing CAPD.
authors.affiliation: Department of Nephrology and Internal Medicine, Medical Academy, Bialystok, Poland. jolmal@poczta.onet.pl
authors.forename: J
authors.initials: J
authors.lastname: Malyszko
authors.forename: J S
authors.initials: JS
authors.lastname: Malyszko
authors.forename: T
authors.initials: T
authors.lastname: Hryszko
authors.forename: S
authors.initials: S
authors.lastname: Brzosko
authors.forename: M
authors.initials: M
authors.lastname: Mysliwiec
mesh_terms: D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D019821:Simvastatin / Q000627:therapeutic use*; D018180:Thrombomodulin / Q000097:blood; D014280:Triglycerides / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D018180:Thrombomodulin; D014280:Triglycerides; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D002784:Cholesterol; D019821:Simvastatin