title: Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.
abstract: We report the case of a 27-year-old woman with hyperthyroidism during pregnancy. Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ). The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring. Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.
authors.affiliation: Second Endocrine Department, Alexandra General Hospital, Athens, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Kontoleon
authors.forename: I
authors.initials: I
authors.lastname: Ilias
authors.forename: D A
authors.initials: DA
authors.lastname: Koutras
authors.forename: D
authors.initials: D
authors.lastname: Kontogiannis
authors.forename: P D
authors.initials: PD
authors.lastname: Papapetrou
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002231:Carbimazole / Q000008:administration & dosage / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011295:Prenatal Care; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil; D002231:Carbimazole