Human protease-activated receptor 1 expression in malignant epithelia: a role in invasiveness.
While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.
Yin
Yong-Jun
YJ
Department of Oncology, Hadassah-University Hospital, POB 12000, Jerusalem 91120, Israel.
Salah
Zaidoun
Z
Grisaru-Granovsky
Sorina
S
Cohen
Irit
I
Even-Ram
Sharona Cohen
SC
Maoz
Myriam
M
Uziely
Beatrice
B
Peretz
Tamar
T
Bar-Shavit
Rachel
R
D000818:Animals; D001940:Breast / Q000098:blood supply / Q000254:growth & development; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D003599:Cytoskeleton / Q000648:ultrastructure; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D016023:Integrins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D044463:Receptor, PAR-1 / Q000502:physiology*; D019030:Receptors, Vitronectin / Q000502:physiology; D013917:Thrombin / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics
D016023:Integrins; D016376:Oligonucleotides, Antisense; D044463:Receptor, PAR-1; D019030:Receptors, Vitronectin; D042461:Vascular Endothelial Growth Factor A; C064660:integrin alphaVbeta5; D013917:Thrombin