title: Intravenous magnesium sulphate effect on maternal serum and amniotic fluid cytokines levels in preterm labour patients.
abstract: Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations. Thirty-six patients at 24-34 weeks of singleton gestation, who presented with contractions (> or = 8 in 60 min) had amniocentesis to rule out intrauterine infection. The patients received intravenous MgSO4 for tocolysis. Twenty-six patients had amniocentesis performed before initiation of MgSO4 (controls) while 10 others had the procedure during tocolytic therapy (study patients). Magnesium, IL-1beta, IL-6, TNFalpha and IL-10 concentrations were measured. Study and control groups were statistically compared using Student t test. Mean magnesium levels were significantly higher in the study group (P < 0.01). There were no significant differences between the cytokines levels in maternal serum and in amniotic fluid between the groups. Our results suggest that the mechanism of magnesium as a tocolytic agent may not be mediated via the examined cytokines.
authors.affiliation: Department of Obstetrics & Gynecology, Soroka University Medical Center, Faculty of health science, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Daphna
authors.initials: D
authors.lastname: Mezad
authors.forename: Mordechai
authors.initials: M
authors.lastname: Hallak
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Huleihel
authors.forename: Limor
authors.initials: L
authors.lastname: Gortzak-Uzan
authors.forename: Ana
authors.initials: A
authors.lastname: Smolin
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000187:drug effects / Q000378:metabolism*; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D008274:Magnesium