title: [Clinical course of pulmonary eosinophilic granuloma--CT evidence of lesion evolution].
abstract: We reviewed a clinicopathological study of pulmonary eosinophilic granuloma focusing on the evolution of pulmonary lesions in chest CT scans. Between 1990 and 2002, five patients with pulmonary eosinophilic granuloma were admitted to our hospital. Clinical features, chest radiographs, pathological characteristics and treatments were evaluated. The scans were repeated in four patients at intervals of at least eight months. All patients were men who smoked. The age at onset of the pulmonary disorders ranged from 22 to 45 years, with a mean of 33 years. Most of the initial chest CT scans showed nodular lesions and thin-walled cysts, but the nodular lesions disappeared or were transformed into cystic lesions in the later scans. Most of the final scans revealed thin-walled cysts and emphysematous lesions. The histopathological characteristics of the nodular lesions in the chest CT were correlated with cellular granulomas mainly composed of Langerhans cells and eosinophils, and small granulomas were also seen in the thin fibrous walls of the cysts. All patients quitted smoking and three showed improvement of the pulmonary lesions within three months.
authors.affiliation: Division of Respiratory Diseases, Toranomon Hospital.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kishi
authors.forename: Sakae
authors.initials: S
authors.lastname: Homma
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kurosaki
authors.forename: Masateru
authors.initials: M
authors.lastname: Kawabata
authors.forename: Eiyasu
authors.initials: E
authors.lastname: Tsuboi
authors.forename: Koji
authors.initials: K
authors.lastname: Narui
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakatani
authors.forename: Noriko
authors.initials: N
authors.lastname: Motoi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Nakata
mesh_terms: D000328:Adult; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed