[Epidemiologic factors and results of treatment in peripheral and peri-hilar cholangiocarcinoma].
OBJECTIVE
Cholangiocarcinoma is a rare malignant tumor that may occur anywhere along intra or extrahepatic biliary tree. Prognosis remains poor with overall 5-year survival rate of 5%. Experience in management of this lesion in Mexico is scarce. Our objective was to report on our experience at the Instituto Nacional de Cancerología in Mexico City with the management of this lesion.


METHODS
A retrospective review of clinical files of patients diagnosed and treated in a period of 10 years was performed. Epidemiologic data, forms of diagnosis, results of management, and survival were analyzed.


RESULTS
From June 1992 to June 2002, 36 patients were diagnosed and treated; 25 patients had perihilar tumor (Klatskin tumor) and 11 had peripheral cholangiocarcinoma. Twenty seven were females (75%) and nine males (25%). Abdominal pain was the main symptom (72%) followed by jaundice (65%) and weight lost (59%). Computed tomography was the most used imaging study (86%); surgery was main form of management (72%). No survivors were observed in patients nor receiving treatment after a follow-up of 3 years. For those resected, an 18%, 5-year survival was observed.


CONCLUSIONS
This lesion was more frequent in females between fifth and seventh decades of life and no relation with ulcerative colitis or primary sclerosing cholangitis was observed in our study. Surgery is still the best form of management but prognosis remains poor.
Martínez-González
María Nancy
MN
Departamento de Gastroenterología, Instituto Nacional de Cancerología, México, D.F.
Mondragón-Sánchez
Ricardo
R
Gómez-Gómez
Elvira
E
Núñez-Nateras
Rafael Alejandro
RA
Bernal-Maldonado
Rigoberto
R
Oñate-Ocaña
Luis F
LF
Ruiz-Molina
Juan Manuel
JM
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000453:epidemiology* / Q000601:surgery*; D017734:Bile Ducts, Extrahepatic; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies