title: Excess coronary artery bypass graft mortality among women with hypothyroidism.
abstract: BACKGROUND
  The impact of thyroid disease on patients undergoing coronary artery bypass grafting has been reported in only small series of selected patients.
  
  
  METHODS
  We investigated 30-day mortality of patients on thyroxine replacement therapy undergoing isolated coronary artery bypass grafting from 1993 to 2000 and identified variables of importance for outcome.
  
  
  RESULTS
  A total of 3,631 patients (606 women) had isolated coronary artery bypass grafting of whom 58 patients (30 women) were treated for hypothyroidism. The mortality rate was higher among women with thyroxine replacement (16.7%, 95% confidence interval [CI] 5.6 to 34.7) than those without thyroxine replacement (5.9%, 95% CI 4.1 to 8.2; p = 0.02) and no difference between men with (3.6%, 95% CI 0.1 to 17.8) and without (2.6%, 95% CI 2.0 to 3.2) thyroxine treatment (p = 0.8). Intake of diuretics (p < 0.001) was directly associated with mortality whereas intake of aspirin (p = 0.01), levothyroxine dose (p = 0.03), and serum thyroxine level (p = 0.01) were inversely associated with mortality among women on thyroxine replacement.
  
  
  CONCLUSIONS
  Women on thyroxine replacement therapy undergoing coronary artery bypass grafting had an increased mortality rate. We speculate that insufficient thyroid hormone replacement could partly play a role in this outcome.
authors.affiliation: Cardiothoracic Directorate, Hammersmith Hospital, London, England.
authors.forename: Dlear
authors.initials: D
authors.lastname: Zindrou
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Taylor
authors.forename: Jens Peder
authors.initials: JP
authors.lastname: Bagger
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D001026:Coronary Artery Bypass / Q000401:mortality*; D004232:Diuretics / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use
chemical_list: D004232:Diuretics; D013974:Thyroxine; D001241:Aspirin