Specialization of tumour vasculature.
Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and their extracellular matrix. These special features of tumour vessels are good targets for cancer therapies.
Ruoslahti
Erkki
E
Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. ruoslahti@burnham.org
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008208:Lymphatic System / Q000473:pathology*; D009369:Neoplasms / Q000098:blood supply* / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D019151:Peptide Library; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism
D014408:Biomarkers, Tumor; D016023:Integrins; D019151:Peptide Library; D040262:Receptors, Vascular Endothelial Growth Factor