title: Influence of benzodiazepines on auditory perception.
abstract: The aim of this study was to test for an influence of benzodiazepine (BZD) on various perceptual and/or cognitive auditory processes. Loudness, auditory selective attention, and the ability of subjects to form perceptual streams out of alternating tone sequences were tested. Nine subjects were tested before, 1, 3, 7, and 24 h after a single-dose oxazepam vs placebo administration in a crossover design. A sample of blood allows us to measure plasma oxazepam concentration. The results revealed a significant reduction in stream segregation expressed as d' scores 1 h after oxazepam intake in the test subjects. No significant change occurred across time in the same subjects when they were administrated a placebo in another session. Furthermore, oxazepam had no substantial and systematic influence either on auditory selective attention or on loudness perception. Altogether, these results suggest that the perceptual organization of sound sequences involves inhibitory neural mechanisms, which can be affected by BZDs. This outcome is consistent with existing models of auditory stream segregation and may be paralleled with earlier findings on the effect of BZDs on perceptual binding in the visual modality.
authors.affiliation: UMR CNRS 5020, Laboratoire Neurosciences et Systèmes Sensoriels, Lyon, Cedex, France. nadege.morand-villeneuve@univ-fcomte.fr
authors.forename: N
authors.initials: N
authors.lastname: Morand-Villeneuve
authors.forename: C
authors.initials: C
authors.lastname: Micheyl
authors.forename: M C
authors.initials: MC
authors.lastname: Gagnieu
authors.forename: P
authors.initials: P
authors.lastname: Lemoine
authors.forename: P
authors.initials: P
authors.lastname: Sebert
authors.forename: L
authors.initials: L
authors.lastname: Collet
authors.forename: E
authors.initials: E
authors.lastname: Veuillet
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D001569:Benzodiazepines / Q000097:blood / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000097:blood / Q000494:pharmacology
chemical_list: D001569:Benzodiazepines; D010076:Oxazepam