title: Cyclocarbopalladation: formation of bicyclic 1,2-cyclobutanediols through a rare 4-exo-dig cyclization.
abstract: [reaction: see text] Several bicyclic compounds bearing a strained 1,2-cyclobutanediol have been prepared from a gamma-bromopropargylic diol under palladium(0) catalysis. The reaction proceeds through a rare unfavored 4-exo-dig cyclocarbopalladation. In some cases, the first reaction is followed by a 6pi-electrocyclization leading to unusual strained tricyclic systems.
authors.affiliation: Université Louis Pasteur de Strasbourg (UMR 7081 CNRS/ULP), Faculté de Pharmacie, 74, route du Rhin, 67401 Illkirch-Cedex, France.
authors.forename: Bahaâ
authors.initials: B
authors.lastname: Salem
authors.forename: Philippe
authors.initials: P
authors.lastname: Klotz
authors.forename: Jean
authors.initials: J
authors.lastname: Suffert