Collapsin response mediator protein-1: a novel invasion-suppressor gene.
Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.
Shih
Jin-Yuan
JY
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Lee
Yuan-Chii G
YC
Yang
Shuenn-Chen
SC
Hong
Tse-Ming
TM
Huang
Chi-Ying F
CY
Yang
Pan-Chyr
PC
D016228:Endothelial Growth Factors / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism; D008938:Mitosis; D009362:Neoplasm Metastasis / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics*; D019913:Nuclear Localization Signals; D010750:Phosphoproteins / Q000737:chemistry / Q000235:genetics*; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D040121:Semaphorin-3A / Q000378:metabolism; D039961:Semaphorins / Q000502:physiology; D015398:Signal Transduction; D020825:T-Box Domain Proteins / Q000378:metabolism; D014158:Transcription, Genetic; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000098855:Collapsin Response Mediator Protein 1
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D009419:Nerve Tissue Proteins; D019913:Nuclear Localization Signals; D010750:Phosphoproteins; D040121:Semaphorin-3A; D039961:Semaphorins; D020825:T-Box Domain Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000098855:Collapsin Response Mediator Protein 1