title: Necrotizing fasciitis caused by dental infection: a retrospective analysis of 9 cases and a review of the literature.
abstract: OBJECTIVE
  Necrotizing fasciitis of the head and neck is an uncommon, potentially fatal soft tissue infection characterized by extensive necrosis and gas formation in the subcutaneous tissue and fascia. The aims of this study were to describe the condition of this rare disease and to find factors affecting the mortality.
  
  
  METHODS
  Nine of our new cases and 125 reported cases in the English-language literature with necrotizing fasciitis of dental origin were reviewed.
  
  
  RESULTS
  Two of our 9 patients had some form of systemic disease such as diabetes, cardiac insufficiency, renal failure, or cerebral infarction, whereas the other 7 had no particular general complications. A computed tomography examination was useful for detecting gas formation in the deep neck. All 9 patients underwent extensive debridement within 24 hours, and good results were obtained. In contrast, 24 of the 125 reviewed patients died despite therapy. Factors affecting the mortality were associated diseases such as diabetes or alcohol abuse, delay of surgery, and the complication mediastinitis.
  
  
  CONCLUSIONS
  Necrotizing fasciitis is still a potentially fatal disease. Early and aggressive debridement may reduce mortality.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kobe University. ume@med.kobe-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umeda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Minamikawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Komatsubara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoo
authors.forename: Takahide
authors.initials: T
authors.lastname: Komori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D005260:Female; D005491:Focal Infection, Dental / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D002097:C-Reactive Protein