title: Early extubation after single-lung transplantation: analysis of the first 106 cases.
abstract: OBJECTIVE
  To determine if a modern anesthetic approach permits extubation immediately after surgery for single-lung transplantation.
  
  
  METHODS
  A retrospective study of all patients undergoing single-lung transplantation from June 1993 to December 1999 in Denmark.
  
  
  METHODS
  Rigshospitalet, Copenhagen University hospital.
  
  
  METHODS
  One hundred six consecutive patients scheduled for single-lung transplantation.
  
  
  METHODS
  From July 1997, the anesthetic approach was changed to facilitate early extubation. The changes included epidural analgesia and short-acting anesthetic drugs.
  
  
  RESULTS
  One hundred six patients were anesthetized for single-lung transplantation. The first 33 patients were moved to the intensive care unit for postoperative mechanical ventilation. After the change of anesthesia technique, 53 of 73 patients were extubated in the operating room. Eleven patients needed reintubation within the first 24 hours because of respiratory insufficiency, pulmonary edema, hemorrhage, or pneumothorax. The need for reintubation increased the length of stay in the intensive care unit by 1 day from 2 to 3 days (NS). The possibility of early extubation or the need for reintubation was not related to age, weight, sex, preoperative condition, mode of transport of the graft, duration of graft ischemia, or side of transplantation.
  
  
  CONCLUSIONS
  This study has shown that it is possible to extubate patients in the operating room immediately after single-lung transplantation in the majority of cases.
authors.affiliation: Department of Cardiothoracic Anesthesia, Copenhagen University Hospital, Rigshospitalet, Denmark. norrekjaer@dadlnet.dk
authors.forename: Lise Nørrekjaer
authors.initials: LN
authors.lastname: Hansen
authors.forename: Jesper B
authors.initials: JB
authors.lastname: Ravn
authors.forename: Stig
authors.initials: S
authors.lastname: Yndgaard
mesh_terms: D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D000701:Analgesics, Opioid / Q000627:therapeutic use; D019162:Anesthetics, Combined; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007442:Intubation, Intratracheal; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use; D015742:Propofol / Q000627:therapeutic use; D000077208:Remifentanil; D012189:Retrospective Studies; D013997:Time Factors; D015300:Ventilator Weaning
chemical_list: D000701:Analgesics, Opioid; D019162:Anesthetics, Combined; D006993:Hypnotics and Sedatives; D010880:Piperidines; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol