title: Feasibility of radioactive embolization of intracranial aneurysms using 32P-implanted coils.
abstract: OBJECTIVE
  Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of 32P per centimeter.
  
  
  METHODS
  We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 microCi/cm of 32P, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of 32P in cystic craniopharyngiomas.
  
  
  RESULTS
  Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment.
  
  
  CONCLUSIONS
  Radioactive coil embolization of aneurysms is feasible in most patients.
authors.affiliation: Department of Radiology, Research Centre of Centre Hospitalier de l'Université de Montréal, Québec, Canada. dr_jean_raymond@hotmail.com
authors.forename: Jean
authors.initials: J
authors.lastname: Raymond
authors.forename: Philippe
authors.initials: P
authors.lastname: Leblanc
authors.forename: Anick
authors.initials: A
authors.lastname: Lambert
authors.forename: Stavros A
authors.initials: SA
authors.lastname: Georganos
authors.forename: François
authors.initials: F
authors.lastname: Guilbert
authors.forename: Christian
authors.initials: C
authors.lastname: Janicki
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Roorda
mesh_terms: D000328:Adult; D000368:Aged; D001610:Beta Particles; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010761:Phosphorus Radioisotopes; D019736:Prostheses and Implants; D012189:Retrospective Studies
chemical_list: D010761:Phosphorus Radioisotopes