title: [Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency].
abstract: Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI-1 activity. A 21-year-old male with congenital PAI-1 deficiency underwent wisdom teeth extraction of the mandible under general anesthesia using propofol, nitrous oxide, sevoflurane, fentanyl, and vecuronium. No complications including prolonged bleeding and rebleeding after the operation were observed because hemostatic management was successful by using intravenous tranexamic acid.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara 634-8522.
authors.forename: Atsuhisa
authors.initials: A
authors.lastname: Kajihara
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kurehara
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Furuya
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kirita
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Fukuda
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000933:Antifibrinolytic Agents / Q000008:administration & dosage; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D019990:Perioperative Care; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency*; D014081:Tooth Extraction; D014148:Tranexamic Acid / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D017395:Plasminogen Activator Inhibitor 1; D014148:Tranexamic Acid