title: Methotrexate-induced acral erythema with bullous reaction.
abstract: Chemotherapy-induced acral erythema (CIAE), a toxic reaction to a number of different chomotherapeutic agents, causes a symmetrical, painful erythema of both the palms and soles which is self-limiting. The association of this syndrome with methotrexate is unusual; only nine cases have been reported in the literature. We describe the tenth case of this syndrome associated with methotrexate, which is also the third case of the bullous variant of methotrexate-induced acral erythema. Our case is unusual in that the acral erythema was present only on the soles of the feet and in that it was associated with the presence of diffuse maculopapular lesions over the legs and trunk.
authors.affiliation: Dermatology Department of Tehran University of Medical Sciences, Iran.
authors.forename: Vida
authors.initials: V
authors.lastname: Feizy
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Namazi
authors.forename: Behrooz
authors.initials: B
authors.lastname: Barikbin
authors.forename: Amirhoushang
authors.initials: A
authors.lastname: Ehsani
mesh_terms: D000293:Adolescent; D004890:Erythema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009061:Mouth Mucosa / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D008727:Methotrexate