title: Urinary antibody titers to Helicobacter pylori and an impact of clinical characteristics.
abstract: This study evaluates the clinical usefulness of titers of antibody to Helicobacter pylori (Hp) in a urine-based enzyme-linked immunosorbent assay (URINELISA; Otsuka Pharmaceutical, Tokushima, Japan) by comparing values of serum antibody to Hp in an already commercialized kit in a population of 250 asymptomatic individuals. Influences of physical and laboratory characteristics on the relationship between serum and urinary titers of antibody to Hp were also estimated using simple and multiple regression analyses. Specific urine gravity, urine pH, proteinuria, and age of the subjects were regarded as significant factors relating to urinary titers of the anti-Hp antibody on simple regression analyses. Both the urinary and serum titers strongly correlated on simple regression analysis (r = 0.782, P < 0.0001). On multiple regression analysis, an additional two factors, specific urine gravity and urine pH, were picked up, and the correlation coefficient was improved (r = 0.795, P < 0.0001). The present results indicate that URINELISA had not only qualitative but quantitative accuracy. However, careful attention should be paid to cases with abnormalities in urinalysis when used quantitatively.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, Japan. kuyama@med.teikyo-u.ac.jp
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Mizue
authors.initials: M
authors.lastname: Tamura
authors.forename: Taro
authors.initials: T
authors.lastname: Ishii
authors.forename: Hajime
authors.initials: H
authors.lastname: Anjiki
authors.forename: Kengo
authors.initials: K
authors.lastname: Hattori
authors.forename: Masaki
authors.initials: M
authors.lastname: Saitoh
authors.forename: Masaki
authors.initials: M
authors.lastname: Sanaka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kuyama
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood* / Q000652:urine*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D016482:Urinalysis
chemical_list: D000907:Antibodies, Bacterial