title: Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast.
abstract: In the February 21 issue of Cell, demonstrate that asymmetrical loading of Kar9 onto astral microtubules (MTs) emanating from the bud-ward-directed spindle pole ensures delivery of this spindle pole to the bud. Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud.
authors.affiliation: Institut Curie, UMR144 du CNRS, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Paoletti
authors.forename: Michel
authors.initials: M
authors.lastname: Bornens
mesh_terms: D017489:CDC28 Protein Kinase, S cerevisiae / Q000235:genetics / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D004718:Saccharomycetales / Q000166:cytology / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: C110443:KAR9 protein, S cerevisiae; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D017489:CDC28 Protein Kinase, S cerevisiae