title: Endogenous granulocyte colony-stimulating factor (G-CSF) levels in chemotherapy-induced neutropenia and in neutropenia related with primary diseases.
abstract: Granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are being administered to patients with neutropenia. However, little is known about the endogenous levels of both factors in these patients. We measured the endogenous G-CSF levels in patients with chemotherapy-induced neutropenia (n=15, study group A), in patients who had not received chemotherapy with neutropenia caused by a number of primary diseases (n=14, study group B) and in healthy volunteers (n=15, control group). Both the study groups and the control group did not show any clinical or laboratory findings of infection. The G-CSF levels were elevated in patients following chemotherapy and in patients who had neutropenia without chemotherapy, but the mean G-CSF levels in patients with chemotherapy-induced neutropenia were significantly higher than in patients with primary diseases. The levels of endogenous G-CSF were also higher in both neutropenic groups, compared to the control group. In conclusion, endogenous G-CSF levels in chemotherapy-induced neutropenia were significantly higher than non-chemotherapy related neutropenia and controls. This may be explained as G-CSF synthesizing bone marrow stromal cells may be more affected in primary disease related neutropenia than in chemotherapy induced neutropenia.
authors.affiliation: Dept. of Medical Oncology, Karadeniz Technical University School of Medicine, Trabzon, Turkey. hkavgaci@meds.ktu.edu.tr
authors.forename: H
authors.initials: H
authors.lastname: Kavgaci
authors.forename: F
authors.initials: F
authors.lastname: Ozdemir
authors.forename: F
authors.initials: F
authors.lastname: Aydin
authors.forename: A
authors.initials: A
authors.lastname: Yavuz
authors.forename: M
authors.initials: M
authors.lastname: Yavuz
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced* / Q000209:etiology; D010976:Platelet Count; D012016:Reference Values
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D016179:Granulocyte Colony-Stimulating Factor