Aliphatic acetylenic homocoupling catalyzed by a novel combination of AgOTs-CuCl2-TMEDA and its application for the solid-phase synthesis of bis-benzo[b]furan-linked 1,3-diynes.
[reaction: see text] A novel catalytic system of AgOTs-CuCl(2)-TMEDA is described for the homocoupling of aliphatic acetylenes on solid support. It is the first observation that Ag(I)'s activating triple bond could facilitate Cu(II)-mediated oxidative acetylenic homocoupling. This study provides an efficient way to synthesize a diversified symmetrical bis-benzo[b]furan-linked 1,3-diyne library on solid support.
Liao
Yun
Y
VivoQuest, Inc., 711 Executive Boulevard, Valley Cottage, New York 10989, USA. y.liao@vivoquest.com
Fathi
Reza
R
Yang
Zhen
Z