title: Characterization and bioavailability of vitamin B12-compounds from edible algae.
abstract: Substantial amounts of vitamin B12 were found in some edible algae (green and purple lavers) and algal health food (chlorella and spirulina tablets) using the Lactobacillus delbrueckii subsp. lactis ATCC7830 microbiological assay method. Corrinoid-compounds were purified and characterized from these algae to clarify the chemical properties and bioavailability of the algal vitamin B12. True vitamin B12 is the predominate cobamide of green and purple lavers and chlorella tablets. Feeding the purple laver to vitamin B12-deficient rats significantly improved the vitamin B12 status. The results suggest that algal vitamin B12 is a bioavailable source for mammals. Pseudovitamin B12 (an inactive corrinoid) predominated in the spirulina tablets, which are not suitable for use as a vitamin B12 source, especially for vegetarians. algal health food, bioavailability, cobalamin, edible algae, vitamin B12
authors.affiliation: Department of Health Science, Kochi Women's University, Kochi 780-8515, Japan. watanabe@cc.kochi-wu.ac.jp
authors.forename: Fumio
authors.initials: F
authors.lastname: Watanabe
authors.forename: Shigeo
authors.initials: S
authors.lastname: Takenaka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kittaka-Katsura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Ebara
authors.forename: Emi
authors.initials: E
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D001682:Biological Availability; D056890:Eukaryota / Q000378:metabolism*; D006801:Humans; D051381:Rats; D014805:Vitamin B 12 / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D014806:Vitamin B 12 Deficiency / Q000178:diet therapy*
chemical_list: D014805:Vitamin B 12