title: Effect of environmental changes on oxidative deoxyribonucleic acid (DNA) damage in systemic lupus erythematosus.
abstract: In a study conducted in Japan, the authors used urinary 8-hydroxydeoxyguanosine (8-OHdG) to study the effects of high-intensity and low-intensity sunlight on oxidative damage to deoxyribonucleic acid (DNA) in patients who had systemic lupus erythematosus (SLE). During late May through early September (i.e., a period of high-intensity sunlight), the mean urinary 8-OHdG level in SLE patients was significantly higher than in controls (31.0 +/- 20.6 [standard deviation] ng/mg vs. 15.4 +/- 7.2 ng/mg, respectively [p < .05]). During late November through early March (i.e., low-intensity sunlight season), however, no significant differences were noted (15.4 +/- 5.5 ng/mg vs. 16.3 +/- 4.6 ng/mg, respectively). The mean urinary 8-OHdG level in SLE patients during the period of high-intensity sunlight was significantly higher than during the period of low-intensity sunlight (21.3 +/- 20.6 ng/mg vs. 12.6 +/- 6.7 ng/mg, respectively; p < .01), although no such seasonal changes were observed among controls (16.2 +/- 8.0 ng/mg vs. 15.7 +/- 5.1 ng/mg, respectively). The effect of sunlight intensity (i.e., season) may require consideration when oxidative DNA damage occurs in individuals who have SLE.
authors.affiliation: Third Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Maeshima
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Liang
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Otani
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mune
authors.forename: Susumu
authors.initials: S
authors.lastname: Yukawa
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D004249:DNA Damage / Q000528:radiation effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine*; D004784:Environmental Monitoring / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000009:adverse effects; D012621:Seasons; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; D017382:Reactive Oxygen Species; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D003849:Deoxyguanosine