title: Human herpesvirus-6 has no apparent influence on course of HCV hepatitis, but may complicate HBV hepatitis and alcoholic liver disease. A pilot study.
abstract: Human herpesvirus-6 (HHV-6) is a widespread virus with occasional reactivation and a potential hepatotropism. The present study was undertaken to investigate the frequency of HHV-6 reactivation in viral (HCV, HBV) and alcoholic liver diseases and its implication for the course of the primary disease. Serological and immunohistochemical tests were done to document viral activity, hepatocellular apoptosis or proliferation, and autoantibody formation. While the course of HCV remains apparently uninfluenced by HHV-6, HBV hepatitis and alcoholic liver disease show a higher incidence of autoantibody formation if HHV-6 is present. The data of this pilot study warrant more extensive investigations of the clinical pathology of HHV-6 in liver diseases.
authors.affiliation: Banco de Sangre, Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico, D.F. julietarojomx@yahoo.com.mx
authors.forename: Julieta
authors.initials: J
authors.lastname: Rojo
authors.forename: Patricia
authors.initials: P
authors.lastname: Simoes
authors.forename: Gerhard R F
authors.initials: GR
authors.lastname: Krueger
authors.forename: Cruz Ortiz
authors.initials: CO
authors.lastname: Humberto
authors.forename: Albert M
authors.initials: AM
authors.lastname: Ramon
mesh_terms: D000914:Antibodies, Viral; D017209:Apoptosis; D001323:Autoantibodies; D002455:Cell Division; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000276:immunology / Q000473:pathology / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D010865:Pilot Projects; D019349:Roseolovirus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D001323:Autoantibodies