Structural genomics of membrane proteins.
A program on the structural genomics of membrane proteins has started at the BIRC, AIST, involving other academic institutions and industrial companies. Emphasis is being put on the development of techniques for the structural determination of membrane proteins of biological importance and ligand-receptor interactions by means of electron microscopy, X-ray diffraction, NMR, and computer simulation. Most efforts at the present stage, however, are being directed to finding suitable expression and purification systems and crystallization conditions for such proteins. The program is expected to be linked with the human full-length cDNA project and should lead to medical and industrial uses.
Kyogoku
Yoshimasa
Y
Biological Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-41-6 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Fujiyoshi
Yoshinori
Y
Shimada
Ichio
I
Nakamura
Haruki
H
Tsukihara
Tomitake
T
Akutsu
Hideo
H
Odahara
Takayuki
T
Okada
Tetsuji
T
Nomura
Nobuo
N
D001436:Bacteriorhodopsins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D016045:Human Genome Project; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation
D008565:Membrane Proteins; D001436:Bacteriorhodopsins