[Osteoporosis associated with primary hyperparathyroidism].
Primary hyperparathyroidism (pHPT) is cited as one of diseases which cause secondary osteoporosis and predominantly affects cortical bone. This disease occurs frequently during the postmenopausal period. Parathyroidectomy (PTX) is the only option available for the radical cure of pHPT and brings about marked increase in bone mass even in postmenopausal women. On the other hand, this disease is now recognized as a disorder with few overt manifestations, presenting as asymptomatic hypercalcemia. Even in these cases, a considerable increase in bone mass can be obtained by PTX. Bisphosphonate as well as estrogen and raloxifene are also reported to increase bone mass in elderly pHPT. patients. These drugs are considered as alternative therapy for mild pHPT patients who have many complications and/or are unfit for surgery.
Sugimoto
Toshitsugu
T
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
D004164:Diphosphonates; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology*; D016105:Parathyroidectomy
D004164:Diphosphonates