Penetration of levofloxacin into human aqueous humor.
This study was designed to measure the concentration of levofloxacin in aqueous humor after topical and oral administration in patients undergoing cataract extraction. Patients were randomly divided into four groups. Levofloxacin concentration in the aqueous humor was the highest in the group in which 600 mg was given orally plus five topical instillations before surgery. The aqueous humor levels of levofloxacin after topical and oral administration exceeded the minimum inhibitory concentrations for certain bacterial species that frequently cause intraocular infection.
Kobayakawa
Shinichiro
S
First Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan. covanet@aol.com
Tochikubo
Tetsuo
T
Tsuji
Akiyoshi
A
D000368:Aged; D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D015817:Eye Infections / Q000188:drug therapy / Q000821:virology; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011897:Random Allocation
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin