Antihyperglycemic and hypoglycemic effect of Aporosa lindleyana in normal and alloxan induced diabetic rats.
The hypoglycemic effect of aqueous and alcoholic extracts of root of Aporosa lindleyana was investigated in both normal and alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. The aqueous and alcoholic extracts of A. lindleyana (100 mg/kg) reduced the blood glucose of normal rat from 80.4+/-2.7 to 69.8+/-2.0 mg% and 82.6+/-1.9 to 70.8+/-3.2 mg%, respectively 3 h after oral administration of the extract (P < 0.001) and also significantly lowered blood glucose level in alloxan induced diabetic rat from 306+/-3.37 to 160+/-2.46 and 328+/-4.15 to 152+/-3.86 mg%, respectively 3 h after oral administration of the extract (P < 0.001). The antihyperglycemic activity of A. lindleyana was compared with tolbutamide, an oral hypoglycemic agent.
Jayakar
B
B
Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Yercaud Road, Salem 636 008, Tamil Nadu, India. jayakar61@yahoo.com
Suresh
B
B
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D019665:Euphorbiaceae / Q000737:chemistry*; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012997:Solvents; D014867:Water
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol