title: What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.
abstract: The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.
authors.affiliation: Technical University of Munich, Department of Genome Oriented Bioinformatics, Freising-Weihenstephan, Germany.
authors.forename: Gertrud
authors.initials: G
authors.lastname: Mannhaupt
authors.forename: Corinna
authors.initials: C
authors.lastname: Montrone
authors.forename: Dirk
authors.initials: D
authors.lastname: Haase
authors.forename: H Werner
authors.initials: HW
authors.lastname: Mewes
authors.forename: Verena
authors.initials: V
authors.lastname: Aign
authors.forename: Jörg D
authors.initials: JD
authors.lastname: Hoheisel
authors.forename: Berthold
authors.initials: B
authors.lastname: Fartmann
authors.forename: Gerald
authors.initials: G
authors.lastname: Nyakatura
authors.forename: Frank
authors.initials: F
authors.lastname: Kempken
authors.forename: Josef
authors.initials: J
authors.lastname: Maier
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schulte
mesh_terms: D002874:Chromosome Mapping; D015825:Chromosomes, Fungal / Q000235:genetics; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D030561:Databases, Nucleic Acid; D016681:Genome, Fungal; D020407:Internet; D009492:Neurospora crassa / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal