[CD4+, CD25+ regulatory T-lymphocytes: current concepts and therapeutic potential].
The subpopulation of CD4 T cells, characterized by a constitutive expression of CD25, plays a critical role in the regulation of multiple auto-immune diseases. These CD4+CD25+ T cells may act by inhibiting the activation of both CD4+ and CD8+ conventional T cells. These cells have a thymic origin and are auto-reactive. They have therapeutic potentials, not only in the control of autoimmune diseases, but also in the control of allograft rejection and graft-versus-host disease.
Salomon
Benoît
B
Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires. CNRS UMR 7087, CERVI, Hôpital de la Pitié-Salpêtrière, Bd de l'hôpital, 75651, Paris.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D015551:Autoimmunity / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D017637:Clonal Deletion; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000637:transplantation; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
D015375:Receptors, Interleukin-2