title: Increased serum matrix metalloproteinase-1 concentration predicts advanced left ventricular remodeling in patients with acute myocardial infarction.
abstract: The left ventricular ejection fraction (LVEF) is one of the major prognostic factors after acute myocardial infarction (AMI) and matrix metalloproteinase-1 (MMP-1) is an enzyme responsible for extracellular collagen degradation and remodeling. The present study investigated whether the concentration of serum MMP-1 was associated with the LVEF after AMI. Blood was sampled on admission, and at 24 h, 3 days, 7 days, 2 weeks and 4 weeks in 24 patients with their first AMI. Left ventriculography was performed 4 weeks after the onset of AMI and the LVEF was calculated by center line method. MMP-1 concentrations were higher at 7 days and at 2 weeks than on admission (p<0.001), and at 7 days (r=-0.655, p=0.0005) and at 2 weeks (r=-0.636, p=0.0008) were negatively correlated with the LVEF. The patients with AMI were divided into high and low LVEF groups according to the results of left ventriculography. Although there were no differences in the clinical characteristics between the 2 LVEF groups, the MMP-1 concentrations at 24 h (p<0.01), 7 days (p<0.01) and 2 weeks (p<0.05) were lower in the high LVEF group than in low LVEF group. A high concentration of MMP-1 at the subacute phase after AMI predicts advanced left ventricular remodeling.
authors.affiliation: Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan. yuuki@gpo.kumamoto-u.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Shinzo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kajiwara
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Jun
authors.initials: J
authors.lastname: Hokamaki
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Suefuji
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyao
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Hiroo
authors.initials: H
authors.lastname: Miyagi
authors.forename: Hideki
authors.initials: H
authors.lastname: Kishikawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009994:Osmolar Concentration; D011379:Prognosis; D011859:Radiography; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D020781:Matrix Metalloproteinase 1