title: Odontoblast function seen as the response of dentinal tissue to dental caries.
abstract: Microbes are responsible for the initiation and maintaining of carious processes. They have an efficient machinery for dissolving crystalline hydroxyapatite. When initiating carious processes, microbial acid formation determines the rate of the process in enamel. When the process reaches dentin, the micro-environment changes. Dential fluid in dentin tubules is the liquid where dissolving products of apatites are destroyed. Inorganic composition of dentinal fluid, however, is not altered much during the carious process, indicating that a functional secretory domain is working to pump the dissolved calcium and phosphate ions out of the fluid. Activation of odontoblast alkaline phosphatase and dentin latent collagenases is the known cellular event during the carious process in dentin. Because the caries lesion is by definition undermining, this suggests that, in this degradation process, the extracellular compartment, crystalline hydroxyapatite is dissolved by microbial acids, and a mixture of proteinases degrades the organic matrix. The degradation products of collagen and other matrix components in dentinal fluid must be transported either through the caries lesion in the enamel to saliva or through the odontoblast to the pulp (active transport). This facilitates further processing of the degradation products intracellularly during the passage through the cell.
authors.affiliation: Institute of Dentistry, University of Oulu, Box 5281, FIN-90401, University Hospital of Oulu, Finland. markku.larmas@oulu.fi
authors.forename: M
authors.initials: M
authors.lastname: Larmas
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000378:metabolism; D003731:Dental Caries / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D003782:Dental Pulp / Q000201:enzymology / Q000378:metabolism; D003804:Dentin / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D019234:Dentinal Fluid / Q000378:metabolism / Q000502:physiology; D004037:Diet, Cariogenic; D019422:Dietary Sucrose / Q000009:adverse effects; D018450:Disease Progression; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009804:Odontoblasts / Q000201:enzymology / Q000502:physiology*; D010710:Phosphates / Q000378:metabolism
chemical_list: D019422:Dietary Sucrose; D010710:Phosphates; D003094:Collagen; D000469:Alkaline Phosphatase; D017364:Collagenases; D002118:Calcium