Formal radical cyclization onto benzene rings--a general method proceeding via cross-conjugated dienones.
Cross-conjugated dienones of type 5 (X = I), which are readily available from phenols, undergo radical cyclization (5 --> 6 --> 7), and the products are easily aromatized (7 --> 8), giving substances that are formally derived by radical cyclization onto a benzene ring (cf. eqn. (1)).
Clive
Derrick L J
DL
Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
Fletcher
Stephen P
SP
Zhu
Mingzhao
M