Immunocontraception for population control: will resistance evolve?
The prospect for successful biocontrol using immunocontraception is threatened if there is adaptation to the vaccine through natural selection of individuals that are genetically resistant to the contraceptive agent. To assess this possibility we examined the literature and found that little relevant data are available for any species on the appropriate trait, fertility variation among immunized individuals, or about appropriate population and genetic parameters influencing the likelihood of a selection response. Some data are available on variation in antibody response to immunocontraceptives, but the relationship between antibody response and fertility levels is poorly documented. The antibody response data indicate low heritability for this trait suggesting that fertility levels of contraceptive-resistant individuals will also have a low heritability. Slow evolution of contraception resistance might therefore be anticipated. The absence of information about relevant parameters makes the construction of quantitative models premature. We discuss factors in particular need of investigation if predictions about resistance evolution are to be made. These include: 1. the genetic basis of fertility retention, 2. the proportion of the population resistant to the contraceptive agent and how this is affected by gene flow from refuge populations, 3. the genetically-based fitness tradeoffs of resistant individuals that often accompany selection, 4. cross-generation effects that can thwart the effects of selection, and 5. the efficiency of delivery of the contraceptive agent. An understanding of the above for particular species, and the development of appropriate divergently acting multiple vaccines that can be used in temporal rotation or in mixtures, should facilitate the development of management options to minimize resistance evolution.
Magiafoglou
Andréa
A
Centre for Environmental Stress and Adaptation Research (CESAR), La Trobe University and CESAR, School of Biological Sciences, Monash University, Melbourne, Victoria, Australia.
Schiffer
Michele
M
Hoffmann
Ary A
AA
McKechnie
Stephen W
SW
D000818:Animals; D000917:Antibody Formation; D003269:Contraception, Immunologic / Q000009:adverse effects* / Q000379:methods; D004351:Drug Resistance / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D011155:Population Control / Q000379:methods*; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic