Familial hyperhomocysteinemia: multiple venous thrombosis in four generations of a family.
We describe a family in which four generations (eight members) had deep vein thrombosis of the lower limb and three of the alive members had documented hyperhomocysteinemia. In addition, one of the family members had evidence of arterial thrombosis in the form of cerebral infarcts. Interestingly, all affected members in the family were males.
Gupta
M
M
Department of Haematology, All India Institute of Medical Sciences, IRCH building 1st floor, Ansari Nagar, 110029 New Delhi, India.
Gupta
S
S
Saxena
R
R
Ahmed
R
R
Choudhry
V P
VP
D000328:Adult; D005492:Folic Acid / Q000627:therapeutic use; D006710:Homocysteine / Q000652:urine; D006801:Humans; D020138:Hyperhomocysteinemia / Q000235:genetics*; D008297:Male; D009599:Nitroprusside; D010375:Pedigree; D020246:Venous Thrombosis / Q000235:genetics*; D014805:Vitamin B 12 / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use
D006710:Homocysteine; D009599:Nitroprusside; D014859:Warfarin; D005492:Folic Acid; D014805:Vitamin B 12