[Bone loss in type 2 diabetes mellitus--diabetic osteopenia].
Loss of bone mineral content has been recognized as one of the chronic complications of type 2 diabetes mellitus, although its mechanism is not fully documented. A negative calcium balance due to both enhanced urinary calcium excretion and decreased intestinal calcium absorption has been occurred because of alteration of vitamin D metabolism and/or decreased parathyroid function. From the view point of bone cell metabolism, osteoblastic bone formation is suppressed by alternation of vitamin D metabolism, hypoparathyroidism, chronic hyperglycemia and insufficient insulin action. On the other hand, osteoclastic bone resorption is rather enhanced. The functional bone uncoupling system between osteoblast and osteoclast in type 2 diabetes mellitus could result in loss of bone density.
Takizawa
Makoto
M
Third Department of Internal Medicine, Kyorin University School of Medicine.
Kameyama
Kokoro
K
Maruyama
Masahiro
M
Ishida
Hitoshi
H
D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002128:Calcium Metabolism Disorders / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006801:Humans