title: Risk factors for surgical site infection in spinal surgery.
abstract: OBJECTIVE
  The objective of this study was to identify specific independent risk factors for surgical site infections (SSIs) occurring after laminectomy or spinal fusion.
  
  
  METHODS
  The authors performed a retrospective case-control study of data obtained in patients between 1996 and 1999 who had undergone laminectomy and/or spinal fusion. Forty-one patients with SSI or meningitis were identified, and data were compared with those acquired in 178 uninfected control patients. Risk factors for SSI were determined using univariate analyses and multivariate logistic regression. The spinal surgery-related SSI rate (incisional and organ space) during the 4-year study period was 2.8%. Independent risk factors for SSI identified by multivariate analysis were postoperative incontinence (odds ratio [OR] 8.2, 95% confidence interval [CI] 2.9-22.8), posterior approach (OR 8.2, 95% CI 2-33.5), procedure for tumor resection (OR 6.2, 95% CI 1.7-22.3), and morbid obesity (OR 5.2, 95% CI 1.9-14.2). In patients with SSI the postoperative hospital length of stay was significantly longer than that in uninfected patients (median 6 and 3 days, respectively; p < 0.001) and were readmitted to the hospital for a median additional 6 days for treatment of their infection. Repeated surgery due to the infection was required in the majority (73%) of infected patients.
  
  
  CONCLUSIONS
  Postoperative incontinence, posterior approach, surgery for tumor resection, and morbid obesity were independent risk factors predictive of SSI following spinal surgery. Interventions to reduce the risk for these potentially devastating infections need to be developed.
authors.affiliation: Division of Infectious Diseases and Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA. molsen@im.wustl.edu
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Olsen
authors.forename: Jennie
authors.initials: J
authors.lastname: Mayfield
authors.forename: Carl
authors.initials: C
authors.lastname: Lauryssen
authors.forename: Louis B
authors.initials: LB
authors.lastname: Polish
authors.forename: Marilyn
authors.initials: M
authors.lastname: Jones
authors.forename: Joshua
authors.initials: J
authors.lastname: Vest
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Fraser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007796:Laminectomy / Q000009:adverse effects* / Q000379:methods; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D013123:Spinal Fusion / Q000009:adverse effects* / Q000379:methods; D013131:Spine / Q000601:surgery*; D013530:Surgical Wound Infection / Q000209:etiology*
chemical_list: D001786:Blood Glucose