Pagetoid reticulosis: a case report and review of the literature.
The histologic finding of a pagetoid epidermotropic growth pattern is associated with a variety of conditions that range from reactive to neoplastic in nature. Included among these conditions is the uncommon skin disorder pagetoid reticulosis. Pagetoid reticulosis may present clinically as a solitary, indolent plaque-like lesion. Conversely, it may manifest as a more generalized clinically aggressive disease. The generalized form may develop into systemic lymphoma, leading to severe morbidity and death. We present a case of pagetoid reticulosis of the perioral region, a rare anatomic site for this condition. Histopathologic and immunohistochemical findings were consistent with a diagnosis of isolated pagetoid reticulosis. This review discusses the nature of pagetoid reticulosis and addresses past and current concepts regarding the condition.
Sedghizadeh
Parish P
PP
Department of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Columbus 43218-2537, USA. sedghizadeh.1@osu.edu
Allen
Carl M
CM
Kalmar
John R
JR
Magro
Cynthia M
CM
D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D008206:Lymphatic Diseases / Q000473:pathology* / Q000532:radiotherapy; D008297:Male