Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol.
Yamamoto
Kana
K
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.
Garbaccio
Robert M
RM
Stachel
Shawn J
SJ
Solit
David B
DB
Chiosis
Gabriela
G
Rosen
Neal
N
Danishefsky
Samuel J
SJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides; D015394:Molecular Structure; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003521:Cyclopropanes; D018841:HSP90 Heat-Shock Proteins; D007783:Lactones; D018942:Macrolides; C477936:cycloproparadicicol; C035359:monorden