title: Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature.
abstract: BACKGROUND
  Endometrial stromal sarcomas (ESSs) exhibit varying degrees of malignancy and heterogeneity at the karyotypic level. The biological mechanisms that contribute to tumorigenesis of ESS are still largely unknown.
  
  
  METHODS
  A 33-year-old woman suffering from ESS was treated primarily surgically. Cytogenetic evaluation of the primary uterine nodule and metastatic tumor showed 46,XX,t(X;17)(p11:q23) karyotype in all metaphases analyzed. Normal endometrial cells exhibited 46,XX karyotype. Fluorescence in situ hybridization analysis confirmed the presence of the reciprocal t(X;17) translocation and allowed for the positioning of the chromosome X breakpoint distal to SSX1 gene loci.
  
  
  CONCLUSIONS
  Our report of a previously undescribed sole cytogenetic translocation in an advanced stage of ESS might identify a cytogenetically distinct subgroup of ESS and help to reveal genes involved in ESS tumorigenesis.
authors.affiliation: Division of Gynecological Oncology, Department of Obstetrics & Gynecology, University Hospitals Leuven, 3000, Leuven, Belgium. Frederic.Amant@uz.kuleuven.ac.be
authors.forename: Frédéric
authors.initials: F
authors.lastname: Amant
authors.forename: Philippe
authors.initials: P
authors.lastname: Moerman
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cadron
authors.forename: Anne
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
mesh_terms: D000328:Adult; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D018203:Sarcoma, Endometrial Stromal / Q000235:genetics*; D014178:Translocation, Genetic