title: Cough reflex sensitivity in cigarette smokers.
abstract: OBJECTIVE
  To evaluate cough reflex sensitivity in a population of young, healthy, male cigarette smokers.
  
  
  METHODS
  Cross-sectional comparison.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Twenty healthy, male current-smokers (mean [+/- SEM] age, 32.2 +/- 1.2 years).
  
  
  METHODS
  Subjects underwent baseline spirometry followed by capsaicin cough challenge testing, which involved the inhalation of capsaicin in ascending, doubling concentrations until the concentrations inducing two or more coughs (C(2)) and those inducing five or more coughs (C(5)) were reached. The data were compared to those from a group of 50 healthy, male nonsmokers who had undergone identical cough challenge testing.
  
  
  RESULTS
  The two groups did not differ in terms of age or baseline pulmonary function. Cough sensitivity was significantly diminished in the current-smokers compared to control subjects. The mean (+/- SEM) log C(2) values in smokers and nonsmokers were 1.26 +/- 0.13 and 0.81 +/- 0.08, respectively (p = 0.004). The mean log C(5) values in smokers and nonsmokers were 2.03 +/- 0.10 and 1.20 +/- 0.08, respectively (p < 0.000001).
  
  
  CONCLUSIONS
  Cough reflex sensitivity is significantly diminished in young, healthy, male current-smokers compared to a similar population of nonsmokers. The mechanism of cough suppression in smokers remains speculative but may involve long-term tobacco smoke-induced desensitization of the cough receptors within the airway epithelium.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. pdicpinigaitis@pol.net
authors.forename: Peter V
authors.initials: PV
authors.lastname: Dicpinigaitis
mesh_terms: D000328:Adult; D002211:Capsaicin; D003371:Cough / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D012021:Reflex, Abnormal; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects*
chemical_list: D002211:Capsaicin