Soluble adhesion molecules in coronary surgery and cardiopulmonary bypass with pump prime aprotinin.
OBJECTIVE
The purpose of the present study was to establish whether pump prime aprotinin could influence soluble adhesion molecules in patients undergoing elective coronary artery bypass surgery.


METHODS
Thirty patients admitted for first-time elective coronary artery bypass surgery were randomized into control or aprotinin groups. Patients in the aprotinin group received 280 mg of aprotinin in the pump prime. Plasma levels of soluble adhesion molecules were analyzed perioperatively.


RESULTS
There were no significant changes in plasma sE-selectin after the operation in either group. Plasma sP-selectin increased significantly up to 20 h after reperfusion to the myocardium. Plasma sICAM-1 decreased in the early stage after cardiopulmonary bypass (CPB), then recovered at 4 h after reperfusion and a significant increase in sICAM-1 was observed 20 h later. There were no significant differences between the groups in postoperative changes in sP-selectin (p = 0.21) and sICAM-1 (p = 0.91).


CONCLUSIONS
Pump prime aprotinin did not influence plasma levels of E-selectin, P-selectin and ICAM-1 in the present patients. The present results do not support the concept of an anti-inflammatory effect of pump prime aprotinin.
Wei
Minxin
M
Division of Cardiothoracic Surgery, Tampere University Hospital, FI-33521 Tampere, Finland.
Laurikka
Jari
J
Kuukasjärvi
Pekka
P
Pehkonen
Erkki
E
Kaukinen
Seppo
S
Laine
Seppo
S
Tarkka
Matti
M
D000368:Aged; D000704:Analysis of Variance; D007611:Aprotinin / Q000008:administration & dosage*; D015415:Biomarkers; D002315:Cardiopulmonary Bypass / Q000379:methods; D001026:Coronary Artery Bypass; D019040:E-Selectin / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage*; D018709:Statistics, Nonparametric
D015415:Biomarkers; D019040:E-Selectin; D019007:P-Selectin; D015842:Serine Proteinase Inhibitors; D018799:Intercellular Adhesion Molecule-1; D007611:Aprotinin