title: Occupational asthma symptoms and respiratory function among aerial pesticide applicators.
abstract: BACKGROUND
  Pesticide exposure has been suggested as one causal factor for the rise in asthma prevalence. The goal of this investigation was to determine the effect of pesticide exposure on respiratory symptoms and lung function in workers with occupational exposure to pesticides.
  
  
  METHODS
  A prospective, case-controlled study was conducted among pesticide aviators (AV) and community controls (Con). In Phase I, subjects completed an asthma survey and baseline spirometry. In Phase II, subjects reported symptoms, lung function monitoring, and pesticide exposure during two, 14-day periods.
  
  
  RESULTS
  Phase I-Self-reported asthma and symptoms were similar among AV (n = 135) and Con (n = 118) with 4-6% prevalence reported but with higher rates among smokers. Baseline lung function was similar; although, a higher proportion of AV had forced expiratory volume in one second (FEV(1)) <80% predicted (8% vs. 2%, P = 0.02). Phase II-Self-reported symptoms were similar with 80% of AV (n = 50) and 73% of Con (n = 49) reporting no symptoms. Only 4% of AV and 6% of controls reported increased symptoms from baseline to spray season. Serial lung function did not differ between group and mean diurnal variation in peak expiratory flow improved in both groups between sampling times (AV 18% vs. 14%; Con 19% vs. 16%, P < 0.001).
  
  
  CONCLUSIONS
  This study suggests that among workers with occupational pesticide exposure, asthma symptoms and lung function are similar to those of controls with only community-based exposure.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas 72202, USA. JonesStacieM@uams.edu
authors.forename: Stacie M
authors.initials: SM
authors.lastname: Jones
authors.forename: A Wesley
authors.initials: AW
authors.lastname: Burks
authors.forename: Horace J
authors.initials: HJ
authors.lastname: Spencer
authors.forename: Shelly
authors.initials: S
authors.lastname: Lensing
authors.forename: Paula K
authors.initials: PK
authors.lastname: Roberson
authors.forename: Jay
authors.initials: J
authors.lastname: Gandy
authors.forename: Rick M
authors.initials: RM
authors.lastname: Helm
mesh_terms: D000328:Adult; D000382:Agricultural Workers' Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D000401:Aircraft; D001131:Arkansas / Q000453:epidemiology; D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000009:adverse effects*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013147:Spirometry; D011795:Surveys and Questionnaires
chemical_list: D010575:Pesticides