Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.
The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.
Vindurampulle
Christofer J
CJ
Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Attridge
Stephen R
SR
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism*; D005822:Genetic Vectors / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control; D022562:Salmonella Vaccines / Q000276:immunology*; D019779:Salmonella enterica / Q000145:classification / Q000276:immunology / Q000472:pathogenicity*; D014613:Vaccines, Attenuated / Q000276:immunology; D000099173:Natural Resistance-associated Macrophage Protein 1
D000907:Antibodies, Bacterial; D027682:Cation Transport Proteins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated; D000099173:Natural Resistance-associated Macrophage Protein 1