title: An evaluation of the multiple dose protocol of cetrorelix in single ovary women.
abstract: BACKGROUND
  The ovarian response and the pregnancy outcome of women with one ovary have been investigated under various IVF stimulation protocols. Cetrorelix is a novel agent offering important advantages in ovarian stimulation. In this study, the multiple protocol of cetrorelix is evaluated in single ovary women, for the first time.
  
  
  METHODS
  Retrospective comparison of the ovarian response and ICSI/ET outcome between 12 cycles of single ovary women and 39 cycles of women with two ovaries.
  
  
  RESULTS
  Between the two groups, there were no statistically significant differences in any of the analysed parameters. In the group of single ovary, 2 pregnancies were achieved and 4 children were born. In the group of two ovaries, 10 pregnancies were achieved and nine children were born.
  
  
  CONCLUSIONS
  Single ovary women have the same response to ovarian stimulation with cetrorelix/hMG/rFSH as women having both ovaries, but they present a lower, although not statistically significant, pregnancy rate.
authors.affiliation: Laboratory of Reproductive Physiology-IVF, Faculty of Medicine, Demokritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Byron
authors.initials: B
authors.lastname: Asimakopoulos
authors.forename: Nikos
authors.initials: N
authors.lastname: Nikolettos
authors.forename: Safaa
authors.initials: S
authors.lastname: al-Hasani
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology* / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix