Varicella vaccination during early pregnancy: a cause of in utero miliary fetal tissue calcifications and hydrops?
BACKGROUND
It is the purpose of this article to describe a suspected association of inadvertent vaccination with varicella vaccine during early pregnancy with the subsequent development of in utero miliary fetal tissue calcifications and fetal hydrops detected by sonogram at 15 weeks of gestation.


METHODS
This is a case presentation of a pregnant patient who received varicella vaccination during the same menstrual cycle that she became pregnant, and is supplemented by a literary review. The fetus developed miliary fetal tissue calcifications and fetal hydrops detected by a targeted sonogram at 15 weeks gestation.


CONCLUSIONS
Varicella vaccination during early pregnancy may be a cause of miliary fetal tissue calcifications and fetal hydrops.
Apuzzio
Joseph
J
Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, Newark, New Jersey 07103-2714, USA. apuzzijj@umdnj.edu
Ganesh
Vijaya
V
Iffy
Leslie
L
Al-Khan
Anthony
A
D000032:Abortion, Therapeutic; D000328:Adult; D002114:Calcinosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002644:Chickenpox / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D015160:Hydrops Fetalis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D018570:Risk Assessment; D012720:Severity of Illness Index; D016216:Ultrasonography, Prenatal; D014611:Vaccination / Q000009:adverse effects
D019433:Chickenpox Vaccine