title: Synthesis and binding affinity of neuropeptide Y at opiate receptors.
abstract: Neuropeptide Y and several metabolic fragments were synthesized and evaluated for binding affinity at non-selective opiate receptors. Neuropeptide Y and several C-terminal fragments were shown to bind to non-selective opiate receptors with an affinity similar to that of Leu-enkephalin.
authors.affiliation: Department of Chemistry, University of North Carolina at Wilmington, 601 South College Road, Wilmington, NC 28403, USA. james.kiddle@wmich.edu
authors.forename: James J
authors.initials: JJ
authors.lastname: Kiddle
authors.forename: Heather J
authors.initials: HJ
authors.lastname: McCreery
authors.forename: Sonia
authors.initials: S
authors.lastname: Soles
mesh_terms: D000595:Amino Acid Sequence; D019167:Appetite Stimulants / Q000138:chemical synthesis / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D011957:Receptors, Opioid / Q000378:metabolism*
chemical_list: D019167:Appetite Stimulants; D009478:Neuropeptide Y; D010446:Peptide Fragments; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine