Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
BACKGROUND
Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.


METHODS
A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.


CONCLUSIONS
We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
Biswas
Abhik K
AK
Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA. akbiswas@mar.med.navy.mil
Zabrocki
Luke A
LA
Mayes
Kendra L
KL
Morris-Kukoski
Cynthia L
CL
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000506:poisoning*; D016642:Bupropion / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008133:Long QT Syndrome / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D010879:Piperazines / Q000506:poisoning*; D013406:Suicide, Attempted; D013844:Thiazoles / Q000506:poisoning*
D000889:Anti-Arrhythmia Agents; D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D016642:Bupropion; C092292:ziprasidone