Epigenetic mechanisms that regulate antigen receptor gene expression.
Functional immunoglobulin and T-cell receptor genes are generated from germline V, D and J gene segments by a series of site-specific recombination events. This process is regulated by the availability of recombination machinery and by the ordered accessibility of appropriate target gene segments. Recent studies highlight the importance of chromatin remodelling and locus positioning for controlling antigen receptor gene expression and recombination.
Bergman
Yehudit
Y
Department of Experimental Medicine and Cancer Research, PO Box 12272, Hebrew University, Jerusalem 91120, Israel. yberg@md.huji.ac.il
Fisher
Amanda
A
Cedar
Howard
H
D000107:Acetylation; D000818:Animals; D019175:DNA Methylation; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin / Q000235:genetics; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D006657:Histones; D009707:Nucleosomes; D011948:Receptors, Antigen, T-Cell