Acute stent thrombosis after early withdrawal of platelet glycoprotein IIb/IIIa antagonists: potential rebound prothrombotic effect?
We report on two cases of acute coronary stent thrombosis after early withdrawal of different competitive inhibitors of the platelet glycoprotein IIb/IIIa receptor, eptifibatide and tirofiban. Differences in pharmacokinetics between different types of glycoprotein IIb/IIIa receptor blockers and a potential rebound prothrombotic effect with the use of these antiplatelet drugs are reviewed.
Angiolillo
Dominick Joseph
DJ
Servicio de Cardiología Intervencionista, Hospital Clínico Universitario San Carlos, Madrid, Spain.
Sabaté
Manel
M
Fernández-Ortiz
Antonio
A
Macaya
Carlos
C
D000208:Acute Disease; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D002404:Catheterization / Q000379:methods; D003131:Combined Modality Therapy; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000628:therapy; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000628:therapy*; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000628:therapy*; D004562:Electrocardiography; D005500:Follow-Up Studies; D006406:Hematoma / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010532:Peritoneal Diseases / Q000000981:diagnostic imaging / Q000628:therapy; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000627:therapeutic use*; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome
D019039:Platelet Glycoprotein GPIIb-IIIa Complex