Muscanone: a 3-O-(1", 8", 14"-trimethylhexadecanyl)naringenin from Commiphora wightii.
A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1", 8",14"-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.
Fatope
Majekodunmi O
MO
Department of Chemistry, College of Science, Sultan Qaboos University, PO Box 36, Al-Khod-123, Muscat, Sultanate of Oman. majek@squ.edu.om
Al-Burtomani
Suad Khamis S
SK
Ochei
John O
JO
Abdulnour
Abdulrahman O
AO
Al-Kindy
Salma M Z
SM
Takeda
Yoshio
Y
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005591:Chemical Fractionation; D029744:Commiphora / Q000737:chemistry*; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D018675:Toxicity Tests / Q000379:methods
D000935:Antifungal Agents; D044950:Flavanones; D005419:Flavonoids; C474271:muscanone; C005273:naringenin; C028610:flavanone