Anti-inflammatory activity of 'TAF' an active fraction from the plant Barleria prionitis Linn.
'TAF' fraction from the methanol-water extract of Barleria prionitis Linn. was evaluated for anti-inflammatory and anti-arthritic activities against different acute and chronic animal test models. It exhibited significant anti-inflammatory activity against different inflammagens like carrageenan, histamine and dextran. The anti-inflammatory activity in adrenalectomised rats was maintained showing that the effect of fraction 'TAF' is not activated by the pituitary-adrenal axis. Significant anti-arthritic activity was observed in adjuvant-induced polyarthritis test in rats. 'TAF' also showed inhibition of vascular permeability and leucocytes migration in vivo into the site of inflammatory insult.Ibuprofen (Cadilla India Ltd., Mumbai) was used as a standard reference drug. The oral (p.o.) LD(50) was more than 3000mg/kg, with no signs of abnormalities or any mortality observed for 15 days after single-dose drug administration. The intraperitoneal (i.p.) LD(50) was found to be 2530mg/kg (+/-87mg/kg S.E.) [Proceedings of Society of Experimental Biological Medicine 57 (1944) 261].
Singh
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B
Departments of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, Canal Road, Jammu 180016, India. bsjaggi2001@yahoo.com
Bani
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Gupta
D K
DK
Chandan
B K
BK
Kaul
A
A
D027901:Acanthaceae / Q000737:chemistry*; D000085:Acetates / Q000494:pharmacology; D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D002464:Cell Migration Inhibition; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005122:Exudates and Transudates / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006632:Histamine; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010936:Plant Extracts; D006632:Histamine; D002351:Carrageenan