title: Recurrent cholestasis due to ampicillin.
abstract: OBJECTIVE
  To present a single case of ampicillin-induced recurrent cholestasis and a literature review.
  
  
  METHODS
  A 23-year-old man was hospitalized due to recurrent and self-limited cholestatic symptoms. He had used ampicillin before each cholestatic attack. He became well clinically and biochemically each time after cessation of the drug. One year after his recovery and discontinuance of ampicillin, the patient has had no recurrence of cholestasis. An objective causality assessment revealed that the adverse drug reaction was probable.
  
  
  CONCLUSIONS
  Ampicillin-related hepatotoxicity is very rare, with injury being mainly hepatocellular. To our knowledge, there is only 1 case report in the literature referring to chronic cholestatic-type hepatotoxicity related to ampicillin.
  
  
  CONCLUSIONS
  Ampicillin, which is one of the most widely used antibiotics, may cause recurrent cholestatic hepatitis. Clinicians should be aware of this adverse effect, and it should be kept in mind during diagnostic workup of liver injury.
authors.affiliation: Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. gskoklu@yahoo.com
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Köklü
authors.forename: Osman
authors.initials: O
authors.lastname: Yüksel
authors.forename: Levent
authors.initials: L
authors.lastname: Filik
authors.forename: Oguz
authors.initials: O
authors.lastname: Usküdar
authors.forename: Kadri
authors.initials: K
authors.lastname: Altundag
authors.forename: Emin
authors.initials: E
authors.lastname: Altiparmak
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000009:adverse effects*; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects*; D012008:Recurrence
chemical_list: D010406:Penicillins; D000667:Ampicillin