title: Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.
abstract: BACKGROUND
  Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.
  
  
  METHODS
  A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.
  
  
  CONCLUSIONS
  We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
authors.affiliation: Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA. akbiswas@mar.med.navy.mil
authors.forename: Abhik K
authors.initials: AK
authors.lastname: Biswas
authors.forename: Luke A
authors.initials: LA
authors.lastname: Zabrocki
authors.forename: Kendra L
authors.initials: KL
authors.lastname: Mayes
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Morris-Kukoski
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000506:poisoning*; D016642:Bupropion / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008133:Long QT Syndrome / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D010879:Piperazines / Q000506:poisoning*; D013406:Suicide, Attempted; D013844:Thiazoles / Q000506:poisoning*
chemical_list: D000889:Anti-Arrhythmia Agents; D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D016642:Bupropion; C092292:ziprasidone