Lamellipodia protrusion: moving interactions of vinculin and Arp2/3.
A direct, transient interaction between vinculin and Arp2/3 is required to promote receptor-stimulated lamellipodial extension and cell spreading. Vinculin selectively recruits Arp2/3 to the leading edge of the lamellipodium, where it may couple the actin polymerization machinery to adhesion complexes to promote membrane protrusion over ruffling.
Craig
Susan W
SW
Department of Biological Chemistry, Johns Hopkins Medical School, 725 N. Wolfe Street, Baltimore, MD 21205, USA. scraig@jhmi.edu
Chen
Hui
H
D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D009068:Movement; D011554:Pseudopodia / Q000502:physiology*; D016596:Vinculin / Q000378:metabolism*
D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D003598:Cytoskeletal Proteins; D016596:Vinculin