Historical review: an energy reservoir for mitosis, and its productive wake.
The realization that DNA is replicated during only a discrete part of interphase in most cells gave birth to the cell-cycle concept exactly half a century ago. But soon thereafter, a controversy arose as to whether a special reservoir of metabolic energy, built up at the end of interphase, was essential for the entry of cells into mitosis. After a period of intense debate, the 'energy reservoir' concept came to a sudden demise. But the notion that mitotic progression involves the cyclic build-up and consumption of key factors endured and, as we all now know so well, eventually triumphed.
Pederson
Thoru
T
Department of Biochemistry and Molecular Pharmacology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester 01605, USA. thoru.pederson@umassmed.edu
D000818:Animals; D001671:Biochemistry / Q000266:history; D002468:Cell Physiological Phenomena; D004247:DNA / Q000378:metabolism*; D004734:Energy Metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008938:Mitosis
D004247:DNA