ErbB-4: mechanism of action and biology.
The most recently described member of the ErbB receptor tyrosine kinase family is ErbB-4. In general, the structure of this receptor and its mechanism of action is similar to that described for ErbB-1. However, significantly less is known about ErbB-4 and there are several novel aspects to its structure, mechanism of action, and biology. This includes the spectrum of ligands that activate ErbB-4, the presence of functionally distinct isoforms, a proteolytic processing pathway to the nucleus, and the capacity to induce a spectrum of cellular responses such as mitogenesis, differentiation, growth inhibition, and survival.
Carpenter
Graham
G
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA. Graham.Carpenter@mcmail.vanderbilt.edu
D000818:Animals; D066246:ErbB Receptors / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D066247:Receptor, ErbB-4
D008024:Ligands; C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4