title: Progression in acute ischemic stroke: frequency, risk factors and prognosis.
abstract: OBJECTIVE
  The aim of this study was to investigate the frequency, possible predictive factors and the prognosis of deteriorating ischemic stroke.
  
  
  METHODS
  A total of 266 stroke patients who presented within 24h of onset were enrolled. Clinical deterioration was defined as a decrease of > or =1 points in the Canadian Neurological Scale (CNS). Rankin Score (RS) was performed at discharge and at six months.
  
  
  RESULTS
  Of the 266 patients studied, 26 (9.8%) worsened. Involvement of posterior circulation (odds ratio (OR) 3.16) and noncardioembolic infarction (OR 4.5) were found to be independently associated with neurological worsening. Death occurred in 19.2% of progressive (P) and in 4.16% of nonprogressive (NP) groups. Functional outcome was worse in the P than in NP patients at discharge and at sixth months.
  
  
  CONCLUSIONS
  Involvement of posterior circulation and noncardioembolic subtypes of infarct independently affect neurological progression in acute ischemic stroke. Clinical deterioration significantly worsens the prognosis.
authors.affiliation: Neurology Department, Zonguldak Karaelmas University Medical Faculty, Neurology Department, 67700 Kozlu Zonguldak, Turkey. mmsumer@ixir.com
authors.forename: Murat
authors.initials: M
authors.lastname: Sumer
authors.forename: Iklim
authors.initials: I
authors.lastname: Ozdemir
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erturk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000209:etiology*; D016009:Chi-Square Distribution; D003710:Demography; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009485:Neuroradiography / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016896:Treatment Outcome