[Oligoastrocytoma with signet-ring cell differentiation. A morphological, ultrastructural and immunohistochemical study].
We present a case of a mixed glial tumor (oligoastrocytoma) with signet-ring cells. This cellular feature is a rare differentiation in glial tumors of the central nervous system. Histological, immunohistochemical and ultrastructural findings have been analyzed. Signet-ring cells showed intense expression with GFAP, S-100 and vimentin. A differential diagnosis with other primary brain tumors and cerebral metástases with signet-ring cell differentiation was discussed.
Ramos
D
D
Hospital Clínico Universitario. Facultad de Medicina. Universidad de Valencia. Valencia. Spain.
Cerdá-Nicolás
M
M
López-Ginés
C
C
Roldán
P
P
Molla
J
J
Pérez-Bacete
M
M
Talamantes
F
F
Barberá
J
J
Llombart-Bosch
A
A
D000328:Adult; D001254:Astrocytoma / Q000473:pathology* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry