title: Topical treatments for onychomycosis: a historical perspective.
abstract: Topical treatment of onychomycosis, in contrast to systemic oral therapy, allows the patient to apply medication directly to the affected area, thereby decreasing the potential for adverse events and drug interactions. Historically, several topical antifungal agents have been used in the treatment of onychomycosis; however, the evidence for their effectiveness is based on very limited data or anecdotal reports. Recently, the development of new, effective topical agents has renewed interest in this form of therapy. As clinical experience with newer topical agents expands, they may be found to be an effective option for the treatment of onychomycosis.
authors.affiliation: Cleveland Foot and Ankle Clinic, Ohio College of Podiatric Medicine, Cleveland 44106, USA.
authors.forename: Myron A
authors.initials: MA
authors.lastname: Bodman
authors.forename: Lisa
authors.initials: L
authors.lastname: Feder
authors.forename: Angela M
authors.initials: AM
authors.lastname: Nace
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000266:history / Q000627:therapeutic use*; D000077768:Ciclopirox; D005533:Foot Dermatoses / Q000188:drug therapy; D049673:History, 20th Century; D006801:Humans; D014009:Onychomycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000266:history; D011728:Pyridones / Q000266:history / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox