RhoD, Src, and hDia2C in endosome motility.
The positioning of early endosomes is a dynamic process requiring coordinated activity of both actin and microtubules with their associated motors. A recent report from Marino Zerial and colleagues examining RhoD identifies mDia2C, a novel splice variant of mDia2, and Src as components of the regulatory machinery influencing actin-dependent endosome movement.
Randazzo
Paul A
PA
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism*
D002352:Carrier Proteins; D019061:src-Family Kinases; C105243:RHOD protein, human; D020741:rho GTP-Binding Proteins