Conversion of the enantiomers of spiro[4.4]nonane-1,6-diol into both epimeric carbaspironucleosides having natural C1' absolute configuration.
[reaction: see text] The enantiomers of spiro[4.4]nonane-1,6-diol have been transformed by different reaction pathways into the two possible carbaspironucleoside epimers with natural C1' absolute stereochemistry.
Paquette
Leo A
LA
Department of Chemistry, Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA. paquette.1@osu.edu
Hartung
Ryan E
RE
France
David J
DJ
D019380:Anti-HIV Agents / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D007202:Indicators and Reagents; D009705:Nucleosides; D013141:Spiro Compounds; C474370:spiro(4.4)nonane-1,6-diol