title: Tissue penetration by ertapenem, a parenteral carbapenem administered once daily, in suction-induced skin blister fluid in healthy young volunteers.
abstract: The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 micro g/ml (the MIC at which 90% of the isolates tested are eliminated) for the entire dosing interval. The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration.
authors.affiliation: Merck & Co., Inc., Brussels, Belgium. tine_laethem@merck.com
authors.forename: T
authors.initials: T
authors.lastname: Laethem
authors.forename: I
authors.initials: I
authors.lastname: De Lepeleire
authors.forename: J
authors.initials: J
authors.lastname: McCrea
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Majumdar
authors.forename: D
authors.initials: D
authors.lastname: Musson
authors.forename: D
authors.initials: D
authors.lastname: Rogers
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Guillaume
authors.forename: A
authors.initials: A
authors.lastname: Parneix-Spake
authors.forename: P
authors.initials: P
authors.lastname: Deutsch
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001768:Blister / Q000378:metabolism*; D004334:Drug Administration Schedule; D000077727:Ertapenem; D005260:Female; D006801:Humans; D007769:Lactams; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D047090:beta-Lactams; D000077727:Ertapenem