title: Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats.
abstract: Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and an anti-platelet agent in biological systems with an anti-arrhythmic effect and a myocardial protective effect on ischemia-reperfusion injury. We examined the neuroprotective effect of honokiol in rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle cerebral artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed (treatment groups). The results showed that there was no significant hemodynamic change after intravenous infusion of honokiol at the dosages of 10(-8), 10(-7) and 10(-6) g/kg in both groups. However, honokiol significantly reduced the total volume of infarction at the doses of 10(-7) or 10(-6) g/kg in both pretreatment and treatment groups. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. This beneficial effect may be related to its antioxidant effect and anti-platelet aggregation activity.
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Kuo-Tong
authors.initials: KT
authors.lastname: Liou
authors.forename: Su-Man
authors.initials: SM
authors.lastname: Lin
authors.forename: Shiang-Suo
authors.initials: SS
authors.lastname: Huang
authors.forename: Chun-Lien
authors.initials: CL
authors.lastname: Chih
authors.forename: Shen-Kou
authors.initials: SK
authors.lastname: Tsai
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control*; D007262:Infusions, Intravenous; D017705:Lignans; D031566:Magnolia; D008297:Male; D008517:Phytotherapy; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D017705:Lignans; D010975:Platelet Aggregation Inhibitors; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols