Angiotensin and insulin resistance: conspiracy theory.
Resistance to the metabolic effects of insulin is a contender for the short list of major cardiovascular risk factors. Since the elements of the syndrome of insulin resistance were first articulated together in 1988, numerous epidemiologic investigations and treatment endeavors have established a relationship between the metabolic disarray of impaired insulin action and cardiovascular disease. Angiotensin II, the primary effector of the renin-angiotensin system, has also achieved a place in the chronicles of cardiovascular risk factors. Conspiracy mechanisms by which angiotensin II and insulin resistance interact in the pathogenesis of cardiovascular disease are reviewed, with particular attention to recent developments in this engaging area of human research.
Townsend
Raymond R
RR
University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia 19104, USA. townsend@mail.med.upenn.edu
D057911:Angiotensin Receptor Antagonists; D000809:Angiotensins / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000502:physiology; D015398:Signal Transduction
D057911:Angiotensin Receptor Antagonists; D000809:Angiotensins; D007328:Insulin; D011945:Receptors, Angiotensin