An unusual expression of hyperplastic gastropathy (Menetrier type) in twins.
Menetrier's disease is an uncommon condition of unknown aetiology. We describe two cases of male identical twins with haematemesis aged 29 and 35 years that exhibited a similar and particular form of this hyperplastic gastropathy. Their stomachs showed confluent polypoid mucosal projections affecting mainly the gastric fundus and the antrum. To the best of our knowledge, only four previous cases have been reported in a familial setting, and this is the first documented example of an occurrence in twins. These two cases suggest the possibility of a genetic predisposition for this condition.
Ibarrola
Carolina
C
Department of Pathology, Hospital 12 de Octubre, Madrid, Spain. ibarrola@hdoc.insalud.es
Rodriguez-Pinilla
Maria
M
Valiño
Cristina
C
Gomez-Casado
Eduardo
E
Garcia de la Torre
Juan Pablo
JP
Rodriguez-Cuellar
E
E
Abad
Alfredo
A
Colina
Francisco
F
D000328:Adult; D004200:Diseases in Twins; D005748:Gastric Fundus / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000473:pathology*; D006801:Humans; D008297:Male; D011706:Pyloric Antrum / Q000473:pathology; D013270:Stomach / Q000473:pathology; D014430:Twins, Monozygotic