title: Three-year prospective randomized study of incidence of posterior capsule opacification in eyes treated with topical diclofenac and betamethasone.
abstract: OBJECTIVE
  To investigate the incidence of posterior capsule opacification (PCO) in eyes treated with diclofenac sodium (DFNa) and betamethasone phosphate (BMS) ophthalmic solutions.
  
  
  METHODS
  A total of 200 eyes with silicone intraocular lens implantation were treated with topical agents for 3 months postoperatively. Twenty-six cases of the DFNa group and 34 of the BMS group met the criteria, and the severity of PCO was evaluated after 3 years.
  
  
  RESULTS
  The results of axial densitometry by Scheimpflug photography were 27.8 computer-compatible tapes (CCT) in the DFNa-treated group and 32.6 CCT in the BMS-treated group (p = 0.1539). Posterior capsulotomy was performed in 11.5% of the DFNa group and 17.6% of the BMS group (p = 0.8375). The photographic grading of PCO showed no difference.
  
  
  CONCLUSIONS
  The incidence of PCO in eyes treated with DFNa appears to be equal to that after BMS treatment.
authors.affiliation: Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Yokohama, Japan.
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ayaki
authors.forename: Takeo
authors.initials: T
authors.lastname: Onishi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kageyama
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yaguchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001623:Betamethasone / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular / Q000009:adverse effects / Q000379:methods; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology; D019591:Pseudophakia / Q000150:complications; D012826:Silicone Elastomers / Q000009:adverse effects; D016037:Single-Blind Method; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012826:Silicone Elastomers; D004008:Diclofenac; D001623:Betamethasone