Intravenous glucose infusion decreases intracisternal thyrotropin-releasing hormone induced vagal stimulation of gastric acid secretion in anesthetized rats.
Gastroparesis is a common complication of diabetes attributed to autonomic neuropathy. This study investigated whether acute hyperglycemia influences central thyrotropin-releasing hormone (TRH), a well-established brain medullary vagal stimulus, induced gastric acid secretion in overnight fasted, urethane-anesthetized rats. Intravenous infusion of D-glucose (20%, 30% and 40%) dose dependently reduced intracisternal TRH-induced gastric acid secretion (71+/-28 micromol/90 min) by 39%, 90% and 100% respectively. Pretreatment with cholecystokinin(A) (CCK(A)) receptor antagonist devazepide (1 mg/kg) did not influence the inhibitory effect of intravenous glucose (30%). These results indicate that hyperglycemia may have a central effect to antagonize medullary TRH stimulation of vagal outflow to the stomach.
Doong
Ming-Luen
ML
Department of Medicine, West Los Angeles Campus, Building 115, Room 203, 11301, Wilshire Boulevard, UCLA, Los Angeles, CA 90073, USA.
Yang
Hong
H
D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D002946:Cisterna Magna / Q000187:drug effects / Q000502:physiology; D005744:Gastric Acid / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017207:Rats, Sprague-Dawley; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D018686:Anesthetics, Intravenous; D013973:Thyrotropin-Releasing Hormone; C027979:L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; D005947:Glucose; D011761:Pyrrolidonecarboxylic Acid