Random and systematic measurement uncertainties considered in the evaluation of parameters derived from the course of the tabletting process.
The uncertainty of some characteristic parameters describing the course of the tabletting process, namely the area quotient according to Emschermann and Müller, the apparent net work, the slope of the Heckel-plot, and the parameters of the modified Weibull function, was calculated according to the German norm DIN 1319-4 1999. The method allows to consider random and systematic uncertainties in a consistent way as variances of normal and rectangular probability distributions, respectively, or other suitable probability distributions based on Bayesian statistics and the principle of maximum entropy. So, random and systematic uncertainties known from a calibration and validation study of the measurement of force and displacement, and the uncertainty of the true density were included meaningfully into the uncertainty of the resulting tabletting parameters using the propagation of uncertainties according to the Gauss method. The standard uncertainty for the results calculated this way seems to be suitable for a critical evaluation of the tabletting data.
Belda
Petra M
PM
Department of Pharmaceutical Technology, Institute of Pharmacy, University of Hamburg, Hamburg, Germany.
Mielck
Jobst B
JB
D001499:Bayes Theorem; D016001:Confidence Intervals; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D011336:Probability; D015203:Reproducibility of Results; D013607:Tablets; D013678:Technology, Pharmaceutical; D035501:Uncertainty
D013607:Tablets