[Immunomodulatory proteins of orthopoxviruses].
The review considers recent data on the structural-functional organization of the genome of orthopoxviruses pathogenic for humans, including the variola, monkeypox, cowpox, and vaccinia viruses. Emphasis was placed on the structure of molecular virulence factors that suppress the inflammatory reactions, immune response, and interferon effects induced by virus infection.
Shchelkunov
S N
SN
Institute of Molecular Biology, Vector State Research Center of Virology and Biotechnology, Ministry of Health of the Russian Federation, Kol'tsovo, Novosibirsk Oblast, 630559 Russia. snshchel@vector.nsc.ru
D000595:Amino Acid Sequence; D000818:Animals; D016679:Genome, Viral; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors; D008969:Molecular Sequence Data; D018155:Orthopoxvirus / Q000472:pathogenicity / Q000502:physiology*; D011213:Poxviridae Infections / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D014774:Virulence / Q000276:immunology
D014764:Viral Proteins; D007372:Interferons