title: Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations.
abstract: The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally administered chilled solutions attained body temperature. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 hr. The bioavailabilities of paracetamol from the xyloglucan gels formed in situ in the stomachs of rabbits after oral administration of the liquid formulations were similar to that of a commercially available suspension containing an identical dose of paracetamol.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari-Tohbetsu, Hokkaido, Japan.
authors.forename: Shozo
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Endo
authors.forename: Naoko
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Wataru
authors.initials: W
authors.lastname: Kubo
authors.forename: Hideki
authors.initials: H
authors.lastname: Watanabe
authors.forename: David
authors.initials: D
authors.lastname: Attwood
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism; D005782:Gels; D005936:Glucans; D066298:In Vitro Techniques; D008297:Male; D019999:Pharmaceutical Solutions; D011134:Polysaccharides / Q000737:chemistry*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology; D012995:Solubility; D013535:Suspensions; D014783:Viscosity; D014990:Xylans
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D005782:Gels; D005936:Glucans; D019999:Pharmaceutical Solutions; D011134:Polysaccharides; D013535:Suspensions; D014990:Xylans; D000082:Acetaminophen; C029353:xyloglucan