Association of peripheral lymphadenopathy with anti-Ro and anti-La antibodies in a family with systemic lupus erythematosus.
We report here a mother and her two daughters suffering from systemic lupus erythematosus, accompanied by the presence of anti-Ro (SSA-52kD and 60kD) and anti-La (SSB) antibodies, and peripheral lymphadenopathy as the first manifestation of the disease. The expression of DR3 and B8 in all three affected family members suggests familiar predisposition to SLE. The differential diagnosis and clinical course are discussed.
Bukiej
Aleksandra
A
Department of Medicine, Institute of Pediatrics Jagiellonian University, School of Medicine, Cracow, Poland.
Undas
Anetta
A
Pituch-Noworolska
Anna
A
Chmielewska
Anna
A
Dyczek
Andrzej
A
Musiał
Jacek
J
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D015795:HLA-B8 Antigen / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D010375:Pedigree
D000974:Antibodies, Antinuclear; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; C035356:SS-A antibodies; C035357:SS-B antibodies