title: Lung function interpolation by means of neural-network-supported analysis of respiration sounds.
abstract: Respiration sounds of individual asthmatic patients were analysed in the scope of the development of a method for computerised recognition of the degree of airways obstruction. Respiration sounds were recorded during laboratory sessions of allergen provoked airways obstruction, during several stages of advancing obstruction. The technique of artificial neural networks was applied for relating sound spectra and simultaneously measured lung function values (spirometry parameter FEV(1)). The ability of feedforward neural networks was tested to interpolate obstruction levels of FEV(1)-classes of which no members were included in the set used for training a network. In this way, a situation was simulated of an existing network recognising a new asthmatic attack under the same physiological conditions. It appeared to be possible to interpolate FEV(1) values, and it is concluded that a deterministic relationship exists between sound spectra and lung function parameter FEV(1). Variance optimisation appeared to be important in optimising the neural network configuration.
authors.affiliation: Biomedical Technology Department, Rijksuniversiteit, Groningen, The Netherlands. oud@bcn.rug.nl
authors.forename: M
authors.initials: M
authors.lastname: Oud
mesh_terms: D001249:Asthma / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D001314:Auscultation / Q000379:methods*; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D016571:Neural Networks, Computer; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D012135:Respiratory Sounds / Q000145:classification* / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity