title: Total knee arthroplasty in hemophilic arthropathy.
abstract: Chronic arthropathy causes major functional disability in patients with severe hemophilia.
  
  
  OBJECTIVE
  To evaluate the results of total knee arthroplasty (TKA) and its impact on both quality of life and clotting factor use in patients with severe hemophilia.
  
  
  METHODS
  We evaluated 17 TKAs in 12 patients. The TKAs were performed between 1986 and 1996, and follow-up was 8-132 months (mean, 54 months). Mean age at arthroplasty was 39 years (22-51 years). Quality of life was evaluated using the Short Form 36 (SF-36).
  
  
  RESULTS
  Results were good or excellent in 94% of patients. The improvement was greatest for pain. Recurrent hemarthrosis in six patients and development of an anticoagulant in two patients were the only postoperative complications. Clotting factor use did not decrease significantly after surgery. SF-36 scores showed an increase in physical activity responsible for an improvement in quality-of-life indicators. However, this improvement in functional capabilities seemed to wane over time as a result of arthropathy in other joints and of intercurrent diseases.
  
  
  CONCLUSIONS
  TKA for hemophilic arthropathy provides good results that translate into quality-of-life gains.
authors.affiliation: Rheumatology department, CHRU Lille, Hôpital Roger Salengro, 59037 Lille cedex, France. i-legroux@chru-lille.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Legroux-Gérot
authors.forename: Guillaume
authors.initials: G
authors.lastname: Strouk
authors.forename: Armelle
authors.initials: A
authors.lastname: Parquet
authors.forename: Jenny
authors.initials: J
authors.lastname: Goodemand
authors.forename: François
authors.initials: F
authors.lastname: Gougeon
authors.forename: Bernard
authors.initials: B
authors.lastname: Duquesnoy
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee; D005169:Factor VIII / Q000191:economics / Q000627:therapeutic use; D005500:Follow-Up Studies; D005102:Health Expenditures; D006467:Hemophilia A / Q000150:complications* / Q000191:economics / Q000628:therapy; D006801:Humans; D007592:Joint Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery; D007720:Knee Prosthesis; D008875:Middle Aged; D011788:Quality of Life; D016059:Range of Motion, Articular; D018434:Sickness Impact Profile
chemical_list: D005169:Factor VIII