Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection.
Single injection of kainate into the dorsal hippocampus of adult mice induced long-lasting hypertrophy and dispersion of dentate granule cells with dendritic hypertrophy and mossy fiber sprouting that resembled human hippocampal sclerosis. Our previous study indicated that brain derived neurotrophic factor was related to the initiation of these morphological changes. In this study, gene expression of the enlarged hippocampus was examined by differential display to find the gene relating to the progression of the pathological changes. Several genes were identified that were overexpressed in the enlarged dentate gyrus. One of them was highly homologous with mouse Flamingo1/Celsr2, suggesting that mouse Flamingo1/Celsr2 is related to the development of hippocampal sclerosis.
Hirai
Hisao
H
Department of Neurosurgery, Shiga University of Medical Science, Tsukinowa-cho, Ohtsu, Seta, Shiga 520-2192, Japan.
Suzuki
Fumio
F
Kurokawa
Kiyoshi
K
Mitsuya
Koichi
K
Matsuda
Masayuki
M
D000818:Animals; D001483:Base Sequence; D015820:Cadherins / Q000096:biosynthesis*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006984:Hypertrophy / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D012689:Sequence Homology, Nucleic Acid
D015820:Cadherins; C498478:Celsr2 protein, mouse; D011956:Receptors, Cell Surface; D007608:Kainic Acid