Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica.
New skeletal flavonoids, anastatins A and B, were isolated from the methanolic extract of an Egyptian medicinal herb, the whole plants of Anastatica hierochuntica. Their flavanone structures having a benzofuran moiety were determined on the basis of chemical and physicochemical evidence. Anastatins A and B were found to show hepatoprotective effects on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes and their activities were stronger than those of related flavonoids and commercial silybin.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kyoto-phu.ac.jp
Xu
Fengming
F
Morikawa
Toshio
T
Ninomiya
Kiyofumi
K
Matsuda
Hisashi
H
D000818:Animals; D019607:Brassicaceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004534:Egypt; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry
D005419:Flavonoids; C477951:anastatin A; C477950:anastatin B