Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in streptozotocin-induced diabetic rats.
The claim by Nigerian traditional herbal medicine practitioners that the silk cotton tree, Ceiba pentandra L. Gaertn (Bombacaceae) barks extract has antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin and graded doses of the aqueous bark extract were then administered ad libitum in drinking water to the experimentally diabetic rats for 28 days. Administration of the aqueous bark extract caused a statistically significant reduction in plasma glucose level in streptozotocin induced diabetic rats. The extract appeared non-toxic as evidenced by normal serum levels of AST, ALT, ALP and bilirubin. The data appear to support the hypoglycemic effects of C. pentandra.
Ladeji
Olusola
O
Department of Biochemistry, Faculty of Medical Sciences, University of Jos, PMB 2084, Jos, Nigeria. ladejio@unijos.edu.ng
Omekarah
Ikechukwu
I
Solomon
Mariam
M
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D035164:Ceiba / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D006029:Glycosuria / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000633:toxicity; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin