title: Long-term follow up study of vertical HTLV-I infection in children breast-fed by seropositive mothers.
abstract: Infection of Human T-lymphotropic virus type-I (HTLV-I) was investigated by long-term follow up surveys of mother's milk-fed infants. HTLV-I infections of infants via seropositive mother's milk, that is, anti-HTLV-I antibody-positive infants, increased in number up to the age 2, but no infants became antibody-positive thereafter. Infants who had became antibody positive by age 2 remained so at age 11-12. HTLV-I infection via feeding with mother's milk was established by the age 2. While in epidemiologic surveys an increase of the anti-HTLV-I antibody-positive rate has been reported, this survey revealed that after acquisition of HTLV-I from breast feeding, there was no further horizontal transmission prior to puberty.
authors.affiliation: Wakayama Medical University, Kihoku Hospital, Obstetrics and Gynecology, Myoji 219, Katsuragi, Ito, Wakayama, 649-7113, Japan. yando@wakayama-med.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Kakimoto
authors.forename: T
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ekuni
authors.forename: M
authors.initials: M
authors.lastname: Kawa
authors.forename: T
authors.initials: T
authors.lastname: Toyama
mesh_terms: D001942:Breast Feeding; D015480:Deltaretrovirus Antibodies / Q000097:blood*; D005260:Female; D006679:HIV Seropositivity / Q000097:blood; D015490:HTLV-I Infections / Q000276:immunology / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008137:Longitudinal Studies
chemical_list: D015480:Deltaretrovirus Antibodies