title: Renal, hepatic, and marrow dysfunction in a patient with chronic renal insufficiency.
abstract: Severe illness with acute renal failure, leukopenia, thrombocytopenia, and coagulopathy frequently occurs with hemolytic uremic syndrome/thrombotic thrombocytopenic purpura, hematological malignancies, sepsis, and collagen-vascular diseases. We present a 16-year-old male fast-food worker with underlying chronic renal insufficiency who manifested these abnormalities as a result of Ehrlichia chaffeensis sepsis. Doxycycline therapy and aggressive supportive care led to complete recovery.
authors.affiliation: Department of Pediatrics, Division of Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Brady
authors.forename: John J
authors.initials: JJ
authors.lastname: Bissler
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D018469:Ehrlichia chaffeensis; D016873:Ehrlichiosis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000382:microbiology*; D007970:Leukopenia / Q000382:microbiology*; D008107:Liver Diseases / Q000382:microbiology*; D008297:Male; D018805:Sepsis / Q000382:microbiology; D013921:Thrombocytopenia / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline