Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down's syndrome.
We report a child with Down's syndrome in whom metrorrhagia and precocious puberty revealed primary autoimmune hypothyroidism. The patient had a decreased growth velocity, exaggerated weight gain, bone age delay, and bilaterally enlarged multicystic ovaries. Delays in the diagnosis and treatment of hypothyroidism can lead to this peculiar presentation.
Chemaitilly
W
W
Paediatric Endocrinology Department, Hôpital Necker Enfants Malades, Paris, France. wassimnet@aol.com
Thalassinos
C
C
Emond
S
S
Thibaud
E
E
D002648:Child; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis; D008796:Metrorrhagia / Q000209:etiology*; D011629:Puberty, Precocious / Q000209:etiology*