title: Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions.
abstract: Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions was examined to verify the hypothesis [Exp. Anim. 46: 225-229, 1997] that Stapylococcus aureus (S. aureus) infection is causally associated with the dermatitis. Observation of the mice up to 28 weeks of age indicated that obvious dermatitis does occur under S. aureus-free conditions, though the incidence was low (six of 42 females and two of 90 males). Skin lesions in the absence of this bacterium showed histological changes very similar to those that can be observed under conventional conditions. In addition, hyperproduction of serum IgE was demonstrated in the dermatitis-positive mouse. These findings suggested that the dermatitis is triggered by IgE-mediated allergic reactions.
authors.affiliation: Developmental Research Laboratories, Shionogi & Co., Ltd., Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nagata
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakao
authors.forename: Susumu
authors.initials: S
authors.lastname: Makino
authors.forename: Minoru
authors.initials: M
authors.lastname: Harada
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D006969:Hypersensitivity, Immediate / Q000150:complications*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013211:Staphylococcus aureus