title: Prophylactic use of mitomycin-C in the management of a buttonholed LASIK flap.
abstract: We report a case in which prophylactic mitomycin-C (MMC) was used to prevent haze and scarring after photorefractive keratectomy (PRK) in an eye with a previous laser in situ keratomileusis flap buttonhole. During the patient's primary procedure, a 3.5 mm central buttonhole was created during the microkeratome pass. The flap was repositioned without laser application. Follow-up examinations revealed a moderate central buttonhole scar. Twelve months later, the patient had PRK with adjunctive MMC 0.02% application in the eye. At the 1-year examination, the uncorrected visual acuity was 20/20 and the cornea was clear with no evidence of scarring or haze.
authors.affiliation: Cornea Service, Department of Ophthalmology, Rush Medical College, Chicago, Illinois, USA.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Lane
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Swale
authors.forename: Parag A
authors.initials: PA
authors.lastname: Majmudar
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D054018:Lasers, Excimer; D016685:Mitomycin / Q000627:therapeutic use*; D018903:Photorefractive Keratectomy; D011183:Postoperative Complications / Q000517:prevention & control*; D012086:Reoperation; D013524:Surgical Flaps; D014786:Vision Disorders / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin