title: Acute renal failure in the ICU: assessing the utility of continuous renal replacement.
abstract: Acute renal failure (ARF) in the ICU patient still remains a common problem and is associated with increased morbidity, mortality, and cost. Potential advantages of continuous renal replacement (CRRT), compared with intermittent hemodialysis (IHD) include enhanced hemodynamic stability, increased solute removal, and greater ultrafiltration. Although it was hoped that CRRT would lead to improvement in patient outcomes, there are few prospective, randomized clinical studies comparing this modality with conventional hemodialysis in the treatment of patients with ARF. The difficulties associated with designing such prospective studies are the complex status of the medical patients and the ethical dilemma of randomizing patients to a certain dialysis modality. At this time, there is no evidence to support the assertion that CRRT improves clinical outcomes compared with IHD.
authors.affiliation: Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario.
authors.forename: Garth
authors.initials: G
authors.lastname: Hanson
authors.forename: Louise
authors.initials: L
authors.lastname: Moist
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D006435:Renal Dialysis; D017582:Renal Replacement Therapy; D013673:Technology Assessment, Biomedical