title: Molecular approaches to spinal cord repair.
abstract: Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.
authors.affiliation: Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4. sdavid11@po-box.mcgill.ca
authors.forename: Samuel
authors.initials: S
authors.lastname: David
authors.forename: Steve
authors.initials: S
authors.lastname: Lacroix
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002921:Cicatrix / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008967:Molecular Biology; D009185:Myelin Proteins / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009433:Neural Inhibition; D000070798:Nogo Proteins; D015398:Signal Transduction / Q000502:physiology; D013119:Spinal Cord Injuries / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
chemical_list: D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D000070798:Nogo Proteins; C000603199:RTN4 protein, human