title: Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
abstract: Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139, USA
authors.forename: Su-Ju
authors.initials: SJ
authors.lastname: Lin
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D005809:Genes, Regulator / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009243:NAD / Q000378:metabolism*; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism
chemical_list: D009243:NAD; D037761:Sirtuins