Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population.
Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young ( approximately 14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and -521 C/T, there was no direct correlation with the personality traits.
Lee
Heon-Jeong
HJ
Department of Psychiatry, Korea University College of Medicine, Anam Hospital, 126-1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea. kuhj@netsgo.com
Lee
Hong-Seock
HS
Kim
Yong-Ku
YK
Kim
Seung-Hyun
SH
Kim
Leen
L
Lee
Min Soo
MS
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
Suh
Kwang-Yoon
KY
Kim
Sangduk
S
D000293:Adolescent; D000483:Alleles; D000704:Analysis of Variance; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D007723:Korea; D018598:Minisatellite Repeats / Q000235:genetics; D010551:Personality / Q000235:genetics*; D010552:Personality Assessment; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D004247:DNA