Effect of estrogen and progestogen on nitric oxide content in rat endometrium.
OBJECTIVE
To observe the effect of estrogen and progestogen on the content of nitric oxide (NO) in the endometrium of SD rats.


METHODS
Fifteen SD rats were divided into control, estrogen and levonorgestrel groups (5 in each group), with corresponding treatment indicated by the designation of the groups. The NO contents in the endometrium were determined by Griess method.


RESULTS
he NO content of estrogen group was significantly higher, while that of levonorgestrel group significantly lower, than that of the control group (P < 0.01 for both comparisons).


CONCLUSIONS
Estrogen and levonorgestrel may regulate NO synthesis in the endometrium.
Zha
Yuan-ping
YP
Department of Obstetrics and Gynecology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
D000818:Animals; D004717:Endometrium / Q000187:drug effects* / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D009569:Nitric Oxide / Q000378:metabolism*; D011372:Progestins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004967:Estrogens; D011372:Progestins; D009569:Nitric Oxide