title: Increase in plasma fibrinogen and plasminogen activator inhibitor level in diabetic KK and KK-Ay mice.
abstract: Coagulation activity in KK mice and KK-Ay mice produced by transferring the yellow obese gene (Ay) into KK mice, was studied to examine whether both mice are useful as a model of diabetic atherosclerosis. Plasma levels of hemoglobin A1c (HbA1c), insulin, fibrinogen, plasminogen activator inhibitor (PAI) and thrombomodulin were significantly high in KK and KK-Ay mice compared with age-matched non-diabetic mice (ddY mice). The changes in the plasma levels of fibrinogen at each time-point correlated with the increases in HbA1c levels. Pathological observation by Oil red O staining of aorta tissue from 4-month-old KK and KK-Ay mice revealed the early stages of atherosclerosis such as lipid deposition. These age-related increases in the plasma level of fibrinogen and PAI suggested that KK-Ay mice may contribute to help elucidate the early stages of diabetic atherosclerosis.
authors.affiliation: Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. okazakim@med.showa-u.ac.jp
authors.forename: Masako
authors.initials: M
authors.lastname: Okazaki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Udaka
authors.forename: Yukako
authors.initials: Y
authors.lastname: Saito
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Koseki
authors.forename: Sumiko
authors.initials: S
authors.lastname: Ohta
authors.forename: Takuya
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Yhuki
authors.initials: Y
authors.lastname: Kamiya
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Amagasa
authors.forename: Katsuji
authors.initials: K
authors.lastname: Oguchi
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000473:pathology; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D015849:Plasminogen Inactivators / Q000097:blood*; D018180:Thrombomodulin / Q000378:metabolism*
chemical_list: D005340:Fibrinogen; D006442:Glycated Hemoglobin; D007328:Insulin; D015849:Plasminogen Inactivators; D018180:Thrombomodulin