[Relationship between the heterotopic neurons and intractable epilepsy].
OBJECTIVE
To discuss the relationship between heterotopic neurons and intractable epilepsy.


METHODS
Epileptogenic zones were precisely located with MRI, video-EEG monitoring, intracranial electrical recording and electrocorticography monitoring and then resected in seven patients. The removed tissue was processed for conventional pathological examination with immunohistochemical staining.


RESULTS
Heterotopic neurons were found in the white matter of the specimens. All the seven cases experienced a favorable outcome, with six seizure free.


CONCLUSIONS
The heterotopic neurons scattered or clustered in the white matter contribute to the pathogenesis of intractable epilepsy.
Yu
Tao
T
Department of Functional Neurosurgy, Xuanwu Hospital, The Capital University of Medical Science. Beijing 100053, China. lengyun318@163.net
Wang
Yuping
Y
Zhang
Guojun
G
Li
Yongjie
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D002828:Choristoma / Q000473:pathology*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009474:Neurons / Q000473:pathology*