Merkel cell carcinoma developing after antithymocyte globulin and cyclosporine therapy for aplastic anemia.
We report a patient who developed Merkel cell carcinoma (MCC) after treatment with antithymocyte globulin and cyclosporine for aplastic anemia. The clinical course was progressive and poor prognosis. Although MCC is relatively rare in second cancers arising after immunosuppressive therapy, patients should be closely monitored for the development of this complication as well as other second malignancies.
Takabayashi
Maki
M
Department of Hematology/Immunology, Fujisawa City Hospital, Fujisawa, Japan. t-maki@swim.seaple.icc.ne.jp
Sakai
Rika
R
Sakamoto
Hiroshi
H
Iemoto
Youichi
Y
Kanamori
Heiwa
H
Inayama
Yoshiaki
Y
Ishigatsubo
Yoshiaki
Y
D000368:Aged; D000741:Anemia, Aplastic / Q000188:drug therapy*; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D015266:Carcinoma, Merkel Cell / Q000139:chemically induced*; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine