[Xanthine derivative compounds potential activity in inflammatory process].
We studied the potentially anti-inflammatory action of some new xanthine compounds, theophylline derivatives with 7-[2-hydroxy-3-(4-acetamido)-phenoxy-propyl]-8-R-1,3-dimethyl-xanthine and 8-R-1,3-bis-(1,3-dimethyl-xanthin-7yl)-2-hydroxy-propane structure substituted in 7 and 8 position. Almost all studied compounds reduced the inflammatory edema, the effect being comparable or highest theophylline. The antiinflammatory effect of theophylline intensified with the introduction in 7 position the theophylinyl radical and in 8 position the bromo, nitro, pirolidinyl, piperidinyl, morfolinyl, imidazolyl, 3,5-dimethyl-pirazolyl, 3-methyl-5-oxo-pirazolyl radicals.
Dănilă
Gh
G
Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Profire
Lenuţa
L
Costuleanu
M
M
D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D003196:Computer Graphics; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000627:therapeutic use; D019820:Xanthine / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D019820:Xanthine; D013806:Theophylline