Neurotransmission of cognition, part 2. Selective NRIs are smart drugs: exploiting regionally selective actions on both dopamine and norepinephrine to enhance cognition.
Selective norepinephrine reuptake inhibitors such as atomoxetine increase both dopamine and norepinephrine in frontal cortex and may thereby enhance cognitive functioning in attention-deficit/hyperactivity disorder.
Stahl
Stephen M
SM
Neuroscience Education Institute, Carlsbad, Calif 92009, USA.
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000502:physiology; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011437:Propylamines / Q000494:pharmacology; D027981:Symporters / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D018759:Adrenergic Uptake Inhibitors; D000928:Antidepressive Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011437:Propylamines; C493227:SLC6A2 protein, human; D027981:Symporters; D000069445:Atomoxetine Hydrochloride; D004298:Dopamine; D009638:Norepinephrine