Microbiological exploitation of the chemokine system.
Several viruses encode chemokine elements in their genome. This review focuses on the roles of such elements in the ongoing battle between the virus and the host. The biological and pharmacological characterizations of several of these chemokine elements have highlighted their importance in the mammalian immune system for antiviral responses and suggested future antiviral and anti-inflammatory therapeutic strategies.
Holst
Peter J
PJ
Laboratory for Molecular Pharmacology, Department of Pharmacology, The Panum Institute, University of Copenhagen, Denmark.
Rosenkilde
Mette M
MM
D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000276:immunology; D006801:Humans; D018716:Molecular Mimicry; D019707:Receptors, Chemokine / Q000378:metabolism; D014780:Viruses / Q000276:immunology* / Q000472:pathogenicity*
D018925:Chemokines; D019707:Receptors, Chemokine