title: Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis.
abstract: A beta-cyclodextrin substituted by an imidazole-bound histamine (CDmh) was successfully used to separate underivatised tryptophan racemate in capillary electrophoresis in the presence of copper(II) ion by the ligand exchange mechanism. To the best of our knowledge, this is the first example of a cyclodextrin derivative behaving as the first coordination sphere ligand in the complex added to the background electrolyte (BGE).
authors.affiliation: Department of Chemical Science, University of Catania, viale A. Doria, 6-, 95125 Catania, Italy. ecucinotta@dipchi.unict.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cucinotta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuffrida
authors.forename: Giulia
authors.initials: G
authors.lastname: Grasso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccarrone
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods; D008024:Ligands; D013237:Stereoisomerism; D014364:Tryptophan / Q000032:analysis*
chemical_list: D003505:Cyclodextrins; D008024:Ligands; D014364:Tryptophan