Usefulness of massive oral nicorandil in a patient with variant angina refractory to conventional treatment.
A 67-year-old man, who was previously diagnosed with vasospastic angina and treated with standard therapy, was admitted to our hospital because of recurrent chest pain refractory to sublingual nitroglycerin. Admission electrocardiography revealed ST segment elevation in II, III and aV(F), and his symptoms were relieved by intravenous bolus administration of nicorandil. He was diagnosed to have active variant angina, and remained symptomatic even after treatment with calcium antagonists and nitrates at optimal doses. Intravenous bolus administration of nicorandil was consistently effective to relieve his symptoms. Anginal attack was finally prevented by massive oral nicorandil in addition to conventional treatment.
Kurisu
Satoshi
S
Division of Cardiology, Hiroshima City Hospital, Hiroshima.
Inoue
Ichiro
I
Kawagoe
Takuji
T
Ishihara
Masaharu
M
Shimatani
Yuji
Y
Nishioka
Kenji
K
Nakamura
Shuji
S
Umemura
Takashi
T
Yoshida
Masashi
M
D000284:Administration, Oral; D000368:Aged; D000788:Angina Pectoris, Variant / Q000175:diagnosis* / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D017023:Coronary Angiography; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D020108:Nicorandil / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000627:therapeutic use; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D020108:Nicorandil; D005996:Nitroglycerin