title: Second malignant neoplasms after treatment of childhood cancer.
abstract: The aim of this study was to determine therapy-related risk factors for the development of second malignant neoplasm (SMN) after childhood cancer. The German Childhood Cancer Registry (GCCR) registers all childhood malignancies since 1980 including SMN. A nested case-control study with 238 SMN cases and 450 controls was conducted. A confirmatory, as well as an explorative, analysis was performed. Radiotherapy showed a small effect on the risk of SMN for doses >or=65 Gy. Regarding the chemotherapeutical agents, we saw increased Odds Ratios (OR) for high doses of cyclophosphamide (CP >8000 mg/m(2) OR=6.3 (95% Confidence Interval (CI): 1.3-30.2)), cisplatinum (DDP >435 mg/m(2) OR=2.8 (95% CI: 1.1-6.7)) and mercaptopurine (MP >5000 mg/m(2) OR=4.5 (95% CI: 1.1-18.9)). Patients jointly receiving high doses of MP (>5000 mg/m(2)) and dexamethasone (DEXA >or=1200 mg/m(2)) had an OR=6.9 (95% CI: 1.2-40.3). Our results could be added to those of other investigations to give indications for modifying future therapeutic strategies for childhood cancer.
authors.affiliation: German Childhood Cancer Registry, Institute for Medical Biometrics, Epidemiology and Informatics, University Mainz, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Michaelis
authors.forename: C
authors.initials: C
authors.lastname: Spix
authors.forename: R
authors.initials: R
authors.lastname: Wibbing
authors.forename: G
authors.initials: G
authors.lastname: Eggers
authors.forename: J
authors.initials: J
authors.lastname: Ritter
authors.forename: P
authors.initials: P
authors.lastname: Kaatsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012042:Registries; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents