[Effect of glycyrrhizin on anti-tuberculosis drug-induced hepatitis].
In cases in which hepatotoxicity developed during anti-tuberculosis chemotherapy, the rapid recovery of liver function is essential for the completion of the anti-tuberculosis chemotherapy protocol. Glycyrrhizin (Stronger Neo-Minophagen C: SNMC) is widely used in Japan for the treatment of patients with drug eruption or chronic hepatitis. However, a consensus on the clinical effects of glycyrrhizin for the treatment of anti-tuberculosis drug-induced hepatitis has not yet been reached. We studied 24 cases who showed abnormal liver function test results while undergoing anti-tuberculosis chemotherapy and who were treated with or without glycyrrhizin. We then compared recovery periods of liver function among both groups. The time required for liver function normalization in the patients who received glycyrrhizin (SNMC, 40 ml daily, intravenously) was 15.1 +/- 4.5 days and the time required for normalization in the non-glycyrrhizin group was 15.2 +/- 5.2 days. The difference was not significant and the fact indicated that glycyrrhizin is not useful for the treatment of anti-tuberculosis drug-induced hepatitis.
Miyazawa
Naoki
N
Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomiokahigashi, Kanazawa-ku, Yokohamashi, Kanagawa 236-0051, Japan. nmiyazawa@dream.com
Takahashi
Hiroshi
H
Yoshiike
Yasuhiro
Y
Ogura
Takashi
T
Watanuki
Yuji
Y
Sato
Masamichi
M
Kakemizu
Nobumasa
N
Yamakawa
Yasushi
Y
U
Chol-han
CH
Goto
Hideto
H
Odagiri
Shigeki
S
D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
D000995:Antitubercular Agents; D019695:Glycyrrhizic Acid