title: [Cloning techniques for mitochondrial diseases and prenatal diagnosis].
abstract: Disorders caused by mutation in the mitochondrial DNA are uncommon. Due to the special pattern of inheritance and of the variability of penetrance the options to affected couples to have healthy children are few. So far traditional prenatal diagnosis is of limited benefit. The problems may be overcome by oocyte donation. However, if the couple wants their own biological offspring, no good method is available today. We discuss ooplasmic and nuclear transfer as possible future options for these couples to have healthy biological children.
authors.affiliation: Göteborgs Universitet, Institutionen för kvinnors och barns hälsa, Enheten for reproduktionsmedicin, Enheten för klinisk genetik.
authors.forename: Charles
authors.initials: C
authors.lastname: Hanson
authors.forename: Jan
authors.initials: J
authors.lastname: Wahlström
mesh_terms: D002648:Child; D019976:Cloning, Organism / Q000379:methods*; D003593:Cytoplasm / Q000637:transplantation; D004272:DNA, Mitochondrial / Q000235:genetics; D018392:Genomic Imprinting; D006801:Humans; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control; D018587:Oocyte Donation; D011296:Prenatal Diagnosis
chemical_list: D004272:DNA, Mitochondrial