title: MR imaging of ischemic penumbra.
abstract: Cerebral ischemic stroke is one of the most fatal diseases despite current advances in medical science. Recent demonstration of efficacy using intravenous and intra-arterial thrombolysis demands therapeutic intervention tailored to the physiologic state of the individual tissue and stratification of patients according to the potential risks for therapies. In such an era, the role of the neuroimaging becomes increasingly important to evaluate the extent and location of tissues at risk of infarction (ischemic penumbra), to distinguish it from unsalvageable infarcted tissues or doomed hemorrhagic parenchyma. In this review, we present briefly the current role and limitation of computed tomography and conventional magnetic resonance imaging (MRI). We also present the possible applications of advanced MR techniques, such as diffusion and perfusion imaging, concentrating on the delineation or detection of ischemic penumbra.
authors.affiliation: Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. abediag-tky@umin.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shirouzu
authors.forename: Akira
authors.initials: A
authors.lastname: Kunimatsu
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Masumoto
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Yamada
authors.forename: Makoto
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Masutani
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion; D020521:Stroke / Q000175:diagnosis*