Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice.
Muscle relaxant effect of Elaeagnus angustifolia L. (Elaeagnaceae) fruit seeds was studied in mice using traction test. The aqueous and ethanolic extracts (i.p) induced a muscle relaxant effect in a dose dependent manner as effective as diazepam (1 mg/kg). The aqueous extract was partitioned with methanol-chloroform (MeCh) and n-butanol (Bu.) saturated with water. The MeCh and Bu. fractions did not show activity. Preliminary phytochemical tests showed that the extract contains flavonoid. The results suggested that E. angustifolia fruit seeds exerted muscle relaxant activity via flavonoid component(s).
Hosseinzadeh
Hossein
H
Department of Pharmacodynamy and Toxicology, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad IR, Iran. hosseinzagehh@yahoo.com
Ramezani
Mohammad
M
Namjo
Nazanin
N
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D031263:Elaeagnaceae / Q000737:chemistry*; D000431:Ethanol; D005638:Fruit / Q000737:chemistry*; D006614:Hindlimb / Q000502:physiology; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000494:pharmacology* / Q000633:toxicity; D018482:Muscle, Skeletal / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D012639:Seeds / Q000737:chemistry; D012997:Solvents; D014867:Water
D009125:Muscle Relaxants, Central; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol; D003975:Diazepam