title: The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy.
abstract: Vasculogenic mimicry reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature; such has been demonstrated in aggressive ovarian carcinoma. This study measured the clinical significance of tumor cell-lined vasculature in ovarian carcinomas (n=77), which was detected in 23 (29.8%) tumors. The data show that tumor cell-lined vasculature was associated with aggressive tumor features and with shorter overall survival (p<0.001). Cox proportional hazards model revealed that tumor cell-lined vasculature (p=0.002) was independently associated with poor survival. This is the first study demonstrating the clinical implications of tumor cell-lined vasculature in ovarian carcinoma.
authors.affiliation: Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 440, Houston, Texas 77030, USA. asood@mdanderson.org
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.forename: Mavis S
authors.initials: MS
authors.lastname: Fletcher
authors.forename: Chris M
authors.initials: CM
authors.lastname: Zahn
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Gruman
authors.forename: Jeremy E
authors.initials: JE
authors.lastname: Coffin
authors.forename: Elisbeth A
authors.initials: EA
authors.lastname: Seftor
authors.forename: Mary J C
authors.initials: MJ
authors.lastname: Hendrix
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D009336:Necrosis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000473:pathology; D015996:Survival Rate