[Endovascular thrombolysis and stent angioplasty for obliteration in cerebral venous sinuses].
OBJECTIVE
To summarize the experience of treating the obliteration of the cerebral venous sinus in 17 patients by using direct thrombolysis and stent angioplasty.


METHODS
All 17 patients with thrombosis and stenosis of the venous sinus were confirmed by digital subtraction angiography. Of these 3 patients had thrombosis in a single sinus and 14 had thrombosis in multiple sinuses. The circulating time was prolonged for over 13 seconds. The micro-catheter was preserved in the sinus for 5 days, followed by infusion of urokinase 1.5 million units and oral warfarin 3-5 mg each day. Stent angioplasty was done for 4 patients with obvious stenosis of the venous sinus detected by DSA after thrombosis.


RESULTS
After contact thrombosis and stent angioplasty in sinuses of the 17 patients, remarkable recanalization of obliterated sinuses was achieved. After treatment, intracranial hypertension pressure (ICP) returned to normal in 7 patients, and 8 thrombosis relapsed in different degree after 7 days. Anticoagulation was prescribed. Only 2 patients showed the ICP above 280 mm H(2)O. No obvious relapse was found in 15 patients during the follow-up for 3-60 months.


CONCLUSIONS
Our results demonstrated that successive thrombolysis and stent angioplasty for occlusion and thrombosis of the venous sinus are effective in promoting drainage of cerebral venous blood and rapidly decreasing ICP.
Li
Baomin
B
Department of Interventioanl Radiology, General Hospital, People's Liberation Army, Beijing 100853, China.
Guo
Mei
M
Li
Sheng
S
Wang
Maoqiang
M
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000800:Angioplasty, Balloon / Q000379:methods*; D000925:Anticoagulants / Q000008:administration & dosage*; D002648:Child; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage; D012851:Sinus Thrombosis, Intracranial / Q000628:therapy*; D015607:Stents; D015912:Thrombolytic Therapy / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage; D014859:Warfarin / Q000008:administration & dosage
D000925:Anticoagulants; D014859:Warfarin; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator