title: Asymmetric alpha-alkylation of phenylacetates using 2-alkylamino-2'-hydroxy-1,1'-binaphthyls as chiral auxiliaries.
abstract: alpha-Alkylation of 2-phenylacetate ester of 2-alkylamino-2'-hydroxy-1,1'-binaphthyls with various alkyl iodides proceeded with good stereoselectivities. An intramolecular hydrogen bonding between N-H group and the carbonyl oxygen seemed to play an important role for asymmetric induction. The auxiliary was also applicable to Diels-Alder reaction of an acrylate.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kawamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurahashi
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kudo