Aztreonam treatment of Pasteurella multocida cellulitis and bacteremia.
OBJECTIVE
To report a case of Pasteurella multocida cellulitis and bacteremia treated successfully with aztreonam.


METHODS
An 81-year-old white man with multiple antibiotic allergies was admitted with severe cellulitis of the left arm and bacteremia due to P. multocida. The patient was treated for 14 days with aztreonam and had complete resolution of the infection.


CONCLUSIONS
To our knowledge, this is the first published case describing successful treatment of P. multocida cellulitis and bacteremia with aztreonam. Antimicrobials recommended for use in P. multocida infections include penicillin, ampicillin, amoxicillin, second- and third-generation cephalosporins, tetracyclines, fluoroquinolones, and trimethoprim/sulfamethoxazole. There is very little information in the current literature regarding the activity of aztreonam toward P. multocida.


CONCLUSIONS
This case demonstrates the potential use of aztreonam for P. multocida cellulitis and bacteremia in those instances where antibiotics of choice cannot be given.
Winner
Jamie S
JS
Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Gentry
Chris A
CA
Machado
Linda J
LJ
Cornea
Paul
P
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001398:Aztreonam / Q000494:pharmacology / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D001733:Bites and Stings; D002415:Cats; D002481:Cellulitis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010326:Pasteurella Infections / Q000188:drug therapy* / Q000382:microbiology; D016979:Pasteurella multocida / Q000187:drug effects / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D001398:Aztreonam