Antioxidant potential in esophageal, stomach and colorectal cancers.
OBJECTIVE
The gastrointestinal tract is particularly susceptible to reactive oxygen species attack which lead to carcinogenesis. An important role in defense strategy against reactive oxygen species is played by antioxidants. The present study aims at examining antioxidant parameters and malondialdehyde--the product of lipid peroxidation as well as the marker of cancer progression--and cancer procoagulant in esophageal, gastric and colorectal cancer patients.


METHODS
The activity of superoxide dismutase, catalase, glutathione peroxidase and reductase and the level of glutathione, vitamin C, malondialdehyde and cancer procoagulant were determined in tumors and normal mucous from 18 patients with esophageal cancer, 18 patients with stomach tumor and 62 patients with colorectal cancer.


RESULTS
In esophageal tumor the activity of all enzymes has been increased compared with normal mucous. Stomach tumor has been also characterized by an increase in antioxidant enzymes activity except glutathione peroxidase and reductase whose activities have been decreased. However in colorectal tumor the activity of enzymes has been increased apart from catalase. In all cases the glutathione level has been increased while the vitamin C content has been significantly decreased. Tumor malondialdehyde level was significantly increased, too. The level of cancer procoagulant also increased in cancer tissues as well as in the serum.


CONCLUSIONS
Antioxidant potential in all cases of gastrointestinal tract cancer has been unbalanced which has lead to increase in reactive oxygen species action and enhancement of lipid peroxidation and cancer procoagulant generation.
Skrzydlewska
Elzbieta
E
Department of Analytical Chemistry Medical Academy, 15-230 Bialystok 8, P.O. Box 14, Poland. skrzydle@amb.ac.bialystok.pl
Kozuszko
Bozena
B
Sulkowska
Mariola
M
Bogdan
Zalewski
Z
Kozlowski
Miroslaw
M
Snarska
Jadwiga
J
Puchalski
Zbigniew
Z
Sulkowski
Stanislaw
S
Skrzydlewski
Zdzislaw
Z
D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000032:analysis; D002374:Catalase / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000378:metabolism* / Q000517:prevention & control; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000378:metabolism* / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D001205:Ascorbic Acid