title: In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
abstract: The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.
authors.affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Crowell
authors.forename: Kolby A
authors.initials: KA
authors.lastname: Sanders-Lewis
authors.forename: W Evan
authors.initials: WE
authors.lastname: Secor
mesh_terms: D000818:Animals; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D014011:Tinidazole / Q000494:pharmacology*; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D014011:Tinidazole; D008795:Metronidazole