title: Preparation of potential inhibitors of the mur-pathway enzymes on solid support using an acetal linker.
abstract: Here, we report a novel strategy for the combinatorial or parallel solid-phase synthesis of potential inhibitors of the mur-pathway enzymes. The strategy involves the efficient use of p-alkoxybenzylidene acetal linker for reversible immobilization of sugar scaffolds to solid phase. This methodology was used to synthesize several glycopeptides on solid phase in good yields.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.
authors.forename: Milana
authors.initials: M
authors.lastname: Maletic
authors.forename: Jelena
authors.initials: J
authors.lastname: Antonic
authors.forename: Aaron
authors.initials: A
authors.lastname: Leeman
authors.forename: Gina
authors.initials: G
authors.lastname: Santorelli
authors.forename: Sherman
authors.initials: S
authors.lastname: Waddell
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D009112:Muramic Acids / Q000378:metabolism*; D019151:Peptide Library
chemical_list: D004791:Enzyme Inhibitors; D006020:Glycopeptides; D009112:Muramic Acids; D019151:Peptide Library