Pro-fibrogenic effects of magnesium deficiency in the cardiovascular system.
Magnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.
Shivakumar
K
K
Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 011, India. shivak@sctimst.ker.nic.in
D009202:Cardiomyopathies / Q000473:pathology; D002318:Cardiovascular Diseases / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism*; D005340:Fibrinogen / Q000096:biosynthesis*; D006801:Humans; D008275:Magnesium Deficiency / Q000378:metabolism* / Q000473:pathology
D005340:Fibrinogen