Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7- (Cp=eta5-C5H5).
A novel polyoxotungstate [CoW(11)O(39)(CpTi)](7-) (Cp=eta(5)-C(5)H(5)) has been prepared. This complex exhibits the highest antitumor activity in vitro among the cyclopentadienyltitanium substituted polyoxometalates investigated and has a remarkable inhibitory action on three types of human cancer cells, SSMC-7721, HL-60 and HLC, in vivo.
Wang
Xiaohong
X
Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
Liu
Jingfu
J
Li
Jianxin
J
Yang
Yong
Y
Liu
Jutao
J
Li
Bin
B
Pope
Michael T
MT
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004563:Electrochemistry; D006801:Humans; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013057:Spectrum Analysis; D014025:Titanium / Q000737:chemistry; D014407:Tumor Cells, Cultured; D017973:Tungsten Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017973:Tungsten Compounds; D004247:DNA; D014025:Titanium