title: Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells.
abstract: Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from L-aspartic acid via L-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide.
authors.affiliation: Department of Applied & Bioapplied Chemistry, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Shikata
authors.forename: Hayato
authors.initials: H
authors.lastname: Niiro
authors.forename: Hideki
authors.initials: H
authors.lastname: Azuma
authors.forename: Taro
authors.initials: T
authors.lastname: Tachibana
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogino
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D013110:Sphingosine / Q000031:analogs & derivatives*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; C064769:N-acetylsphingosine; D013110:Sphingosine