title: Usefulness of massive oral nicorandil in a patient with variant angina refractory to conventional treatment.
abstract: A 67-year-old man, who was previously diagnosed with vasospastic angina and treated with standard therapy, was admitted to our hospital because of recurrent chest pain refractory to sublingual nitroglycerin. Admission electrocardiography revealed ST segment elevation in II, III and aV(F), and his symptoms were relieved by intravenous bolus administration of nicorandil. He was diagnosed to have active variant angina, and remained symptomatic even after treatment with calcium antagonists and nitrates at optimal doses. Intravenous bolus administration of nicorandil was consistently effective to relieve his symptoms. Anginal attack was finally prevented by massive oral nicorandil in addition to conventional treatment.
authors.affiliation: Division of Cardiology, Hiroshima City Hospital, Hiroshima.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurisu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Inoue
authors.forename: Takuji
authors.initials: T
authors.lastname: Kawagoe
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ishihara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimatani
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishioka
authors.forename: Shuji
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Umemura
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000788:Angina Pectoris, Variant / Q000175:diagnosis* / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D017023:Coronary Angiography; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D020108:Nicorandil / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000627:therapeutic use; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D020108:Nicorandil; D005996:Nitroglycerin