title: Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration.
abstract: Recombinant human TSH (rhTSH) has been proposed as an alternative method to the withdrawal of thyroid hormones in the follow-up of differentiated thyroid cancer. The aim of the present study was to evaluate the influence of several demographic and anthropometric parameters [age, body weight, height, body mass index, and body surface area (BSA)] on serum peak TSH levels after rhTSH administration. rhTSH was administered to 112 patients with differentiated thyroid carcinoma according to the conventional two-dose schedule (0.9 mg/d). Serum TSH levels were measured 24 h before and after the first administration of rhTSH, and then 24, 48, and 72 h after the second administration of rhTSH. In one severely obese patient, serum peak TSH values did not reach a valid stimulation range. Serum peak TSH levels were negatively related to body weight (r = -0.69; P < 0.0001), body mass index (r = -0.51; P < 0.0001), and BSA (r = -0.72; P < 0.0001). In a multivariate regression analysis including demographic and anthropometric variables, only BSA was independently associated to serum peak TSH concentrations (standardized beta coefficient = -0.721; P < 0.0001). In conclusion, body size seems to influence serum peak TSH levels after rhTSH administration. Future studies should evaluate the possibility of using personalized rhTSH doses, adjusted in relation to BSA.
authors.affiliation: Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, 80127 Napoli, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitale
authors.forename: Gelsy Arianna
authors.initials: GA
authors.lastname: Lupoli
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciccarelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Lucariello
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Fittipaldi
authors.forename: Francesco
authors.initials: F
authors.lastname: Fonderico
authors.forename: Annalisa
authors.initials: A
authors.lastname: Panico
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lupoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001830:Body Surface Area; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000097:blood / Q000188:drug therapy*; D013972:Thyrotropin / Q000097:blood* / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D013972:Thyrotropin