Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma.
BACKGROUND
An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation suggested a role of specific IgG (sIgG) in the development of TDI asthma.


METHODS
We observed the changes in the levels of specific IgE and IgG antibodies to TDIHSA conjugate in TDI-induced asthmatic patients during seven years avoidance.


RESULTS
Six subjects with high sIgE and five with high sIgG were enrolled. All of them had taken anti-asthmatic medications with complete avoidance. Serum levels of sIgE and sIgG to TDI-HSA conjugate were detected by ELISA. The level of sIgE continued to decline up to 7 years and the mean half-life was 3.9 years. The mean half-life of sIgG was 4.5 yrs.


CONCLUSIONS
These findings suggest that both sIgE and sIgG to TDI-HSA conjugate may persist for several years after the last exposure to TDI.
Park
Hae Sim
HS
Department of Allergy & Rheumatology, Ajou University School of Medicine, Paldalgu, Wonchondong San-5, Suwon, Korea. hspark@madang.ajou.ac.kr
Lee
Soo Keol
SK
Lee
Young Mok
YM
Kim
Sun Sin
SS
Nahm
Dong Ho
DH
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000276:immunology*; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects / Q000276:immunology*
D015415:Biomarkers; D007074:Immunoglobulin G; D012709:Serum Albumin; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E