title: A case of subglottic carcinoma effectively treated with intraluminal irradiation using low dose rate iridium-192 thin wires combined with external beam irradiation.
abstract: Subglottic carcinoma is rare and has a poor prognosis. It is usually treated with surgical resection, external beam irradiation (EBR) and/or a combination of both. Intraluminal irradiation (IR) as a curative treatment for subglottic carcinoma has never been reported. We report a case of subglottic carcinoma in a 66-year-old man, who was effectively treated with IR combined with EBR. IR was conducted using low dose rate iridium-192 thin wires at a subglottic mucosal dose of 5.1-6.0 Gy per fraction, with a total dose of 43.8 Gy in eight fractions. EBR was administered, using cobalt-60 and 6 MV X-rays delivered at 2 Gy per fraction, with a total dose of 66 Gy in 33 fractions. Complete response was obtained without serious complications and no recurrence occurred in the 79-month follow-up period. IR combined with EBR is useful as a potential curative treatment. It should be considered as one of the treatment options for subglottic carcinoma.
authors.affiliation: Department of Oncological Science, Division of Morphological Diagnosis and Less Invasive Therapy, Oita Medical University, Oita, Japan. wakisaka@oita-med.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Wakisaka
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fuwa
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tachibana
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kodaira
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furutani
authors.forename: Minoru
authors.initials: M
authors.lastname: Kamata
authors.forename: Hiromu
authors.initials: H
authors.lastname: Mori
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods*
chemical_list: D007496:Iridium Radioisotopes