Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
The CYP2D6 gene codes for human cytochrome P450 2D6 enzyme, which is responsible for the metabolism of many psychiatric drugs. In schizophrenic patients treated with neuroleptics, decreased or loss of function CYP2D6 alleles may contribute to the development of tardive dyskinesia (TD), a movement disorder that frequently occurs with chronic neuroleptic treatment. The goal of this study was to determine whether the occurrence of TD is associated with CYP2D6 genotype in a cohort of Korean schizophrenics by employing a CYP450 GeneChip((R)) oligonucleotide microarray and PCR assays to screen for 19 CYP2D6 alleles. Our results revealed that males with at least one decreased or loss of function allele have a moderately greater chance of developing TD than males with only wild-type alleles. Female schizophrenics did not have a significantly greater chance of developing TD. Our results demonstrate the utility of CYP2D6 microarrays to assess genotype status in this Korean cohort.
Nikoloff
D
D
Roche Molecular Systems, Pharmacogenetics Department, Alameda, CA, USA.
Shim
J C
JC
Fairchild
M
M
Patten
N
N
Fijal
B A
BA
Koch
W H
WH
MacPherson
A
A
Flockhart
D
D
Yoon
Y R
YR
Yoon
J S
JS
Kim
Y H
YH
Shin
J G
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007723:Korea; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D012737:Sex Factors; D018709:Statistics, Nonparametric
D019389:Cytochrome P-450 CYP2D6