Synthetic RNA-dependent DNA polymerase activity in normal rat liver and hepatomas.
Normal adult rat liver contains a high level of a synthetic RNA-dependent DNA polymerase activity, which is distinct from cellular DNA-dependent polymerases. It uses poly(dT).poly(rA) and poly(rA).poly(rU) as templates but has little or no response to DNA or several single-stranded RNAs.
Ward
D C
DC
Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London WC2.
Humphryes
K C
KC
Weinstein
I B
IB
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D002850:Chromatography, Gel; D007525:Isoelectric Focusing; D008099:Liver / Q000201:enzymology*; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity; D013698:Templates, Genetic
D012194:RNA-Directed DNA Polymerase