Effect of immune modulation on TT virus (TTV) and TTV-like-mini-virus (TLMV) viremia.
The present study was designed to investigate how two chronically replicating viruses, TT virus (TTV) and TTV-like mini virus (TLMV), interact with host defence systems. Successive serum samples from three groups of subjects, undergoing modifications of their antiviral defence, were tested by real-time PCR to measure changes in viral titers, and by sequence analyses to indicate whether increases in viremia could be attributed to infection with an unfamiliar strain: 1) in patients receiving immunosuppressants subsequent to kidney transplantation, viral titers tended to increase; 2) in soldiers undergoing extreme training known to cause immunosuppression, insignificant increases in titers were observed; and 3) interferon treatment of patients with hepatitis C virus caused a temporary decrease in TTV and TLMV titers. Increases in viremia were associated only occasionally with the appearance of novel strains. The above results add to knowledge on how these viruses are influenced by the host.
Moen
Eva Merethe
EM
Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway.
Sagedal
Solbjørg
S
Bjøro
Kristian
K
Degré
Miklos
M
Opstad
Per Kristian
PK
Grinde
Bjørn
B
D017925:Circovirus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D004266:DNA Virus Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000821:virology; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology; D006801:Humans; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008889:Military Personnel; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D022783:Torque teno virus / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D014766:Viremia / Q000188:drug therapy / Q000821:virology*
D006508:Hepatitis Antibodies; D007372:Interferons