Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey.
Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNA(Ser(UCN)) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three deaf children with A1555G (1.8%) but no examples of A7445G. One proband with the mitochondrial A1555G mutation has also evidence for right parietal infarct on a brain imaging study, for which common thrombotic mutations were found to be negative.


CONCLUSIONS
This study shows that the mitochondrial A1555G mutation is among the significant causes of prelingual non-syndromic deafness in the Turkish population.
Tekin
M
M
Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey. mtekin@medicine.ankara.edu.tr.|Birlik Mah 8. Cadde No 8/3, Çankaya, 06610, Ankara, Turkey. mtekin@medicine.ankara.edu.tr.
Duman
T
T
Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
Boğoçlu
G
G
Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
İncesulu
A
A
Dept. of ENT, Ankara Social Security Hospital, Ankara, Turkey.
Çomak
E
E
Dept. of Pediatrics, Suleyman Demirel University School of Medicine, Isparta, Turkey.
Fitoz
S
S
Dept. of Radiodiagnostics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
Yılmaz
E
E
Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
İlhan
I
I
Dept. of Pediatrics, Suleyman Demirel University School of Medicine, Isparta, Turkey.
Akar
N
N
Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
D000293:Adolescent; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics*; D003638:Deafness / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial