Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation.
We present the case of a newborn male with D-transposition of the great arteries, ventricular septal defect, and subpulmonary stenosis who experienced two episodes of systemic-to-pulmonary artery shunt thrombosis. Hematologic evaluation revealed heterozygous factor V Leiden mutation. This report emphasizes the importance of evaluation for inherited coagulation disorders in pediatric patients with unexpected thrombotic complications.
Simsic
Janet M
JM
Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. simsicjm@musc.edu
Uber
Walter E
WE
Lazarchick
John
J
Bradley
Scott M
SM
D000714:Anastomosis, Surgical; D025861:Blood Coagulation Disorders, Inherited / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D011651:Pulmonary Artery / Q000601:surgery*; D013927:Thrombosis / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V