Hydrolysis of surfactant phospholipids catalyzed by phospholipase A2 and eosinophil lysophospholipases causes surfactant dysfunction: a mechanism for small airway closure in asthma.
Ackerman
Steven J
SJ
University of Illinois at Chicago (Dr. Ackerman, Mr. Kwatia and Ms. Doyle), Chicago, IL 60612-7334, USA. sackerma@uic.edu
Kwatia
Mark A
MA
Doyle
Christine B
CB
Enhorning
Goran
G
D000402:Airway Obstruction / Q000150:complications / Q000201:enzymology*; D000818:Animals; D001249:Asthma / Q000150:complications / Q000201:enzymology*; D002384:Catalysis / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D008245:Lysophospholipase / Q000494:pharmacology*; D051379:Mice; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D010743:Phospholipids / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000494:pharmacology*
D010743:Phospholipids; D011663:Pulmonary Surfactants; D010741:Phospholipases A; D054467:Phospholipases A2; D008245:Lysophospholipase