title: Synthesis and antibacterial study of 10, 15, 20-triphenyl-5-(4-hydroxy-3-(trimethylammonium)methyl)phenylporphyrin as models for combination of porphyrin and alkylating agent.
abstract: 10, 15, 20-Triphenyl-5-(4-hydroxy-3-(trimethylammonium)methyl)phenylporphyrin 4 and its zinc complex 5 have been synthesized and antibacterial activities have been studied for 4 and its derivative. Compound 4 showed stronger inhibition than that of 10, 15, 20-triphenyl-5-(4-hydroxy-3-(dimethylamine)methyl)phenylporphyrin (2) and 10, 15, 20-triphenyl-5-(4-methoxy-3-(trimethylammonium)methyl)phenylporphyrin (6). It is possible that antibacterial activity of compound 4 involved in photoinducing both o-quinone methide intermediate and singlet oxygen formation.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei Wuhan 430072, PR China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiao Lian
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
chemical_list: C478045:10, 15, 20-triphenyl-5-(4-hydroxy-3-(trimethylammonium)methyl)phenylporphyrin; D000477:Alkylating Agents; D000900:Anti-Bacterial Agents; D011166:Porphyrins; D000644:Quaternary Ammonium Compounds