title: The relationship between central corneal thickness and Goldmann applanation tonometry.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between Goldmann applanation tonometry and central corneal thickness in a large sample of healthy eyes.
  
  
  METHODS
  Five hundred eyes of 500 subjects (253 women, 50.6 per cent and 247 men, 49.4 per cent) were analysed in a prospective healthy population study. Mean age of the sample was 31 +/- 8 years. Goldmann applanation tonometry was carried out by one physician. Tonometric values were the mean of three consecutive readings. Subsequently, another physician carried out ultrasonic pachymetry with the DGH 2000 AP ultrasonic pachymeter (DGH Technology Inc, San Diego, USA). Ten measurements were made at the centre of the cornea of each eye. The lowest value was used for analysis.
  
  
  RESULTS
  Applanation tonometry and central corneal thickness were correlated (r = 0.184, p < 0.001). There was no significant correlation between corneal thickness and age (r = 0.083, p = 0.065), mean spherical equivalent refraction (r = 0.083, p = 0.065) or visual acuity (r = 0.036, p = 0.187).
  
  
  CONCLUSIONS
  In normal eyes, there is no statistically significant correlation between changes of intraocular pressure and changes of central corneal thickness but they suggest a relationship between intraocular pressure and central corneal thickness. Goldmann applanation tonometry has a systematic error in accuracy of intraocular pressure readings of healthy eyes caused by its dependence on central corneal thickness. Measurement of corneal thickness by optometrists should be the first step in diagnosing intraocular pressure pathologies.
authors.affiliation: Rahhal Ophthalmology Clinic, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lleó
authors.forename: Asunción
authors.initials: A
authors.lastname: Marcos
authors.forename: Manuel
authors.initials: M
authors.lastname: Calatayud
authors.forename: Luis
authors.initials: L
authors.lastname: Alonso
authors.forename: Saleh M
authors.initials: SM
authors.lastname: Rahhal
authors.forename: Juan A
authors.initials: JA
authors.lastname: Sanchis-Gimeno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003315:Cornea / Q000033:anatomy & histology*; D019781:Corneal Topography / Q000379:methods; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D014065:Tonometry, Ocular / Q000379:methods*