title: Debulking prior to stenting--a worthwhile effort?
abstract: The rationale of debulking prior to stenting is to improve acute and long-term results of complex lesion angioplasty by reduction of plaque burden and/or reduction of calcified material prior to stenting, thus, allowing subsequent optimized stent-implantation and expansion. There are several registries analyzing the effect of various debulking-strategies prior to stenting in groups of selected patients and in high-risk subgroups. The majority of these studies performed DCA prior to stenting. In summary, these studies showed a reduction in restenosis rates and need for reintervention at long-term follow-up. The total TLR-rate (PCI, CABG) during a mean follow-up of 6 to 14 months is reported to be 4 to 14%; the rate of restenosis is given as 7 to 14%. However, until now, no large scale randomised "debulking prior to stenting" versus "conventional stenting without debulking" study has been published in detail. Several studies suggest benefit for debulking prior to stenting in complex lesion subsets, e.g., total chronic occlusions, ostial lesions, bifurcation lesions and saphenous vein grafts, but as of now, no convincing strategy has evolved.
authors.affiliation: Heinrich-Heine-Universität Universitätsklinikum Medizinische Klinik und Poliklinik B Moorenstrasse 5 40225 Düsseldorf, Germany. heintzen@uni-duesseldorf.de
authors.forename: Matthias P
authors.initials: MP
authors.lastname: Heintzen
authors.forename: Omer
authors.initials: O
authors.lastname: Aktug
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Michel
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017225:Atherectomy, Coronary; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery / Q000628:therapy*; D023903:Coronary Restenosis / Q000517:prevention & control / Q000601:surgery; D004562:Electrocardiography; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D053685:Laser Therapy; D009203:Myocardial Infarction / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D015607:Stents; D013997:Time Factors