title: Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders.
abstract: OBJECTIVE
  Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis.
  
  
  METHODS
  We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases.
  
  
  RESULTS
  The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p = 0.0014).
  
  
  CONCLUSIONS
  Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.
authors.affiliation: Department of Gastroenterology, Tohoku University Postgraduate School of Medicine, Sendai.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Obana
authors.forename: Sho
authors.initials: S
authors.lastname: Takagi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kinouchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tokita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sekikawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hiwatashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D016022:Case-Control Studies; D016922:Cellular Senescence / Q000502:physiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D012016:Reference Values; D012680:Sensitivity and Specificity; D016615:Telomere / Q000235:genetics / Q000648:ultrastructure*