Different expression of cytokines in survivors and non-survivors from MODS following cardiovascular surgery.
OBJECTIVE
Cardiopulmonary bypass is often associated with pathophysiological changes in form of systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS). In the present study, we investigated plasma levels of pro- and anti-inflammatory cytokines in survivors and non-survivors from MODS in the early postoperative course following open heart surgery.


METHODS
Prospective clinical study.


METHODS
A University Cardiothoracic Intensive Care Unit.


METHODS
Levels of cytokines (IL-6, IL-8, IL-10, IL-18, and TGF- ) and procalcitonin (PCT) were measured at the first four postoperative days in 16 adult male patients with an Apache II-score >24 and two or more organ dysfunctions after myocardial revascularization.


RESULTS
All pro-inflammatory cytokines, except for IL-6, were significantly elevated in non-survivors from MODS, with peak values at the first two postoperative days. The plasma levels of immunoinhibitory cytokines showed no differences between the groups.


CONCLUSIONS
The results of our study show a different expression of pro-inflammatory cytokines in survivors and non-survivors from MODS following operations with extracorporeal circulation. In addition to Apache-II score, especially IL-8, IL-18, and PCT may be used as parameters for the prognosis of patients with organ dysfunctions after cardiac surgery.
Sablotzki
A
A
Clinic of Cardiothoracic Surgery, University of Halle, Halle, Germany. sablotzki@aol.com
Dehne
M G
MG
Friedrich
I
I
Grond
S
S
Zickmann
B
B
Mühling
J
J
Silber
R E
RE
Czeslick
E G
EG
D018806:APACHE; D000368:Aged; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood*; D006785:Hospitals, University; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood* / Q000150:complications / Q000401:mortality; D009204:Myocardial Revascularization / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications / Q000097:blood* / Q000401:mortality; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology / Q000401:mortality
C000606589:CALCA protein, human; D016207:Cytokines; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide