[An observation of repair of burn wound with consanguineous skin pretreated with Tripterygium wilfordii].
OBJECTIVE
To explore new source of skin for burn wound coverage.


METHODS
Split-thickness consanguineous skin was harvested from New Zealand white rabbit and was soaked in 200 g/L of multi-peptides of Tripterygium wilfordii, 50 g/L of dexamethasonel, on 9 g/L of normal saline solution for 15 - 30 mins, respectively. The consanguineous skin was thereafter grafted onto the whole layer skin defects in filial generation of rabbits with non-consanguineous skin as the control. The survival time and rejection of the grafted skin was observed.


RESULTS
The rejection appeared evidently less intense and survived significantly longer (43 +/- 3.5 days) when the consanguineous skin was pretreated by Tripterygium wilfordii. However the grafted consanguineous skin survived for 30 +/- 2.5 days when it was pretreated by dexamethasone. The grafted skin was quickly rejected and survived only for 11 +/- 1.6 days when the skin was pretreated by normal saline or the skin was non-consanguineous.


CONCLUSIONS
Consanguineous skin possessed partial compatibility with the recipient due to similar antigen, which was beneficial to the its survival, especially after the skin was pretreated.
You
Guifang
G
Department of Burns, Yuebei People's Hospital, Shaoguan, 512026 P.R. China.
Liang
Lühua
L
Zheng
Langsheng
L
Luo
Xinzhong
X
Li
Jincai
J
Qiu
Junqi
J
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002056:Burns / Q000601:surgery*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D016038:Skin Transplantation / Q000379:methods*; D014185:Transplantation, Isogeneic; D029757:Tripterygium; D014945:Wound Healing
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D003907:Dexamethasone