Trypanocidal and leishmanicidal properties of substitution-containing chalcones.
Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.
Lunardi
Fabiane
F
Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade do Vale do Itajaí Departamento de Microbiologia e Parasitologia, Florianópolis, Santa Catarina, Brazil.
Guzela
Michel
M
Rodrigues
Andrea T
AT
Corrêa
Rogério
R
Eger-Mangrich
Iriane
I
Steindel
Mário
M
Grisard
Edmundo C
EC
Assreuy
Jamil
J
Calixto
João B
JB
Santos
Adair R S
AR
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D002599:Chalcone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007892:Leishmania braziliensis / Q000187:drug effects*; D009593:Nitroimidazoles / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014349:Trypanosoma cruzi / Q000187:drug effects*
D009593:Nitroimidazoles; D002599:Chalcone; D000666:Amphotericin B; C009999:benzonidazole