An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii.
We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a variant of the gene cassette ere(A), coding for an erythromycin esterase, whose nucleotide sequence shares 93.7% DNA identity with ere(A) from Escherichia coli BM2195 plasmid pIP1100.
Plante
Isabelle
I
Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, 2705 Boul. Laurier, Québec, Canada.
Centrón
Daniela
D
Roy
Paul H
PH
D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002874:Chromosome Mapping; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D032023:Integrons / Q000235:genetics*; D008969:Molecular Sequence Data; D011532:Providencia / Q000201:enzymology* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D004269:DNA, Bacterial; D002265:Carboxylic Ester Hydrolases; C046388:erythromycin esterase