title: Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC.
abstract: Staphylococci are ubiquitous colonizers of the skin and mucous membranes and Staphylococcus aureus is the most pathogenic species. The spread of antibiotic resistance among S. aureus strains is a major concern in the treatment of staphylococcal infections. Acquisition of resistance may involve mutation of a bacterial gene on the chromosome or transfer of a resistance gene from other organisms by some form of genetic exchange (conjugation, transduction, or transformation). Completion of whole genome sequences of three methicillin-resistant S. aureus (MRSA) strains has provided us a bird's-eye view of the distribution of the mobile genetic elements in the bacterial chromosome that encode antibiotic resistance as well as pathogenicity in S. aureus.
authors.affiliation: Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. teruybac@med.juntendo.ac.jp
authors.forename: Teruyo
authors.initials: T
authors.lastname: Ito
authors.forename: Keiko
authors.initials: K
authors.lastname: Okuma
authors.forename: Xiao Xue
authors.initials: XX
authors.lastname: Ma
authors.forename: Harumi
authors.initials: H
authors.lastname: Yuzawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
mesh_terms: D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D016106:Methicillin Resistance / Q000235:genetics; D009154:Mutation; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements