title: Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep.
abstract: An experimental population (1216 lambs from 30 sires) of the Inra401 sheep was created in an Inra flock to allow QTL detection for susceptibility to Salmonella infection, wool and carcass traits. The Inra401 is a sheep composite line developed from two breeds: Berrichon du Cher and Romanov. At 113 days of age on average, the lambs were inoculated intravenously with 10(8) Salmonella abortusovis Rv6 (vaccinal strain). They were slaughtered 10 days after the inoculation. Several traits were measured at inoculation and/or slaughtering to estimate the genetic resistance of the lambs to Salmonella infection: specific IgM and IgG1 antibody titres, body weight loss, spleen and pre-scapular node weights and counts of viable Salmonella persisting in these organs. This paper presents a quantitative analysis of the genetic variability of the traits related to salmonellosis susceptibility. The heritabilities of the traits varied between 0.10 and 0.64 (significantly different from zero). Thus, in sheep as well as in other species, the determinism of resistance to Salmonella infection is under genetic control. Moreover, the correlations between the traits are in agreement with the known immune mechanisms. The genetic variability observed should help QTL detection.
authors.affiliation: Station d'amélioration génétique des animaux, Institut national de la recherche agronomique, BP 27, 31326 Castanet-Tolosan Cedex, France. moreno@toulouse.inra.fr
authors.forename: Carole R
authors.initials: CR
authors.lastname: Moreno
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lantier
authors.forename: Patricia
authors.initials: P
authors.lastname: Berthon
authors.forename: Anne V
authors.initials: AV
authors.lastname: Gautier-Bouchardon
authors.forename: Roger
authors.initials: R
authors.lastname: Boivin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lantier
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Brunel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Weisbecker
authors.forename: Dominique
authors.initials: D
authors.lastname: François
authors.forename: Jacques
authors.initials: J
authors.lastname: Bouix
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Elsen
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001837:Body Weights and Measures; D015169:Colony Count, Microbial; D014644:Genetic Variation / Q000235:genetics; D008957:Models, Genetic; D040641:Quantitative Trait Loci / Q000235:genetics; D012481:Salmonella Infections, Animal / Q000276:immunology*; D022562:Salmonella Vaccines / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022562:Salmonella Vaccines