title: Method for analysis of polymer-supported organic compounds using mass spectrometry direct insertion.
abstract: A new approach on the use of mass spectrometry direct-insertion and a quadrupole detector for analysis of organic compounds supported in solid phase has been developed. This is a simple and efficient method based on cleavage due to the thermal-instability of the benzylic group of most commercial resins. The cleavage of supported compounds takes place in the spectrometer as a consequence of the high temperature in the instrument's chamber. These compounds are detected using a similar fragmentation pattern and a molecular ion corresponding to the same compound obtained by traditional synthesis. Polymer degradation fragments do not interfere with the spectrum interpretation, because only a few peaks and low intensities are detected. We report here the identification of different types of compounds supported in Merrifield resin, such as bis-o-aminobenzamides and simple aromatic and aliphatic compounds, using this new approach.
authors.affiliation: Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000, Tijuana, B. C. México.
authors.forename: D
authors.initials: D
authors.lastname: Chávez
authors.forename: A
authors.initials: A
authors.lastname: Ochoa
authors.forename: D
authors.initials: D
authors.lastname: Madrigal
authors.forename: M
authors.initials: M
authors.lastname: Castillo
authors.forename: K
authors.initials: K
authors.lastname: Espinoza
authors.forename: T
authors.initials: T
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Vélez
authors.forename: J
authors.initials: J
authors.lastname: Meléndez
authors.forename: J D
authors.initials: JD
authors.lastname: García
authors.forename: I A
authors.initials: IA
authors.lastname: Rivero