title: Trypanocidal and leishmanicidal properties of substitution-containing chalcones.
abstract: Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.
authors.affiliation: Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade do Vale do Itajaí Departamento de Microbiologia e Parasitologia, Florianópolis, Santa Catarina, Brazil.
authors.forename: Fabiane
authors.initials: F
authors.lastname: Lunardi
authors.forename: Michel
authors.initials: M
authors.lastname: Guzela
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Rodrigues
authors.forename: Rogério
authors.initials: R
authors.lastname: Corrêa
authors.forename: Iriane
authors.initials: I
authors.lastname: Eger-Mangrich
authors.forename: Mário
authors.initials: M
authors.lastname: Steindel
authors.forename: Edmundo C
authors.initials: EC
authors.lastname: Grisard
authors.forename: Jamil
authors.initials: J
authors.lastname: Assreuy
authors.forename: João B
authors.initials: JB
authors.lastname: Calixto
authors.forename: Adair R S
authors.initials: AR
authors.lastname: Santos
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D002599:Chalcone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007892:Leishmania braziliensis / Q000187:drug effects*; D009593:Nitroimidazoles / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D009593:Nitroimidazoles; D002599:Chalcone; D000666:Amphotericin B; C009999:benzonidazole