Low blood selenium concentrations in schizophrenic patients on clozapine.
OBJECTIVE
To compare plasma and red-cell selenium concentrations of schizophrenic patients treated with clozapine, with healthy controls and patients with mood disorders.


METHODS
Plasma and red-cell selenium concentrations were measured in random venous blood samples from four groups: mood disorder (n = 36), schizophrenics treated with clozapine (n = 54), schizophrenics not treated with clozapine (n = 41) and a healthy control group (n = 56). Assays were performed by an independent laboratory that was blinded to the patient groups and specializes in estimating trace metal concentrations.


RESULTS
Selenium concentrations in plasma and red cells were found to be significantly lower in schizophrenic patients treated with clozapine as compared with all other groups.


CONCLUSIONS
Selenium is an essential antioxidant. Its deficiency has been implicated in myocarditis and cardiomyopathy. Low selenium concentrations in clozapine-treated patients may be important in the pathogenesis of life threatening cardiac side-effects associated with clozapine. Further clinical studies are being conducted to explore this important clinical observation and its therapeutic implications.
Vaddadi
K S
KS
Department of Psychological Medicine (Monash University), Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia. vaddadi@hotmail.com
Soosai
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E
Vaddadi
G
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D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000097:blood / Q000188:drug therapy; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012643:Selenium / Q000097:blood*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D012702:Serotonin Antagonists; D012643:Selenium; D003024:Clozapine