title: Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines.
abstract: [reaction: see text] An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degrees C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D017605:Bromine Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*
chemical_list: D000588:Amines; D017605:Bromine Compounds; D003300:Copper