A toxicological evaluation of 2-dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride.
2-Dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride (3) is a novel cytotoxic and anticancer agent. The objective of this study was to obtain information pertaining to possible toxic symptoms detected by in vivo evaluations in mice and an in vitro test for mutagenicity. The data obtained revealed that 3 had no effect on alanine transaminase, aspartate transaminase, HDL cholesterol and protein concentrations in sera nor were variations in the numbers of red and white blood cells detected. Furthermore autopsies of treated mice revealed no pathological symptoms in the heart, kidney, brain, spleen and testes. However elevation of the concentrations of total cholesterol, triglycerides, creatinine and urea were noted in treated mice as well as inflammation of the liver and lungs. Chromosomal aberrations were detected in a micronuclei test. In the Ames test, compound 3 was converted into one or more mutagens in the presence (but not the absence) of a murine liver homogenate. Thus future molecular modifications of 3 should bear in mind approaches to reduce or minimize unwanted side effects.
Dimmock
J R
JR
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Zello
G A
GA
Vashishtha
S C
SC
Hayes
S J
SJ
Mutalik
S
S
Kumar
S
S
Venkatesh
M
M
Udupa
N
N
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D007274:Injections, Intraperitoneal; D008111:Liver Function Tests; D008352:Mannich Bases / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D011427:Propiophenones / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
C472747:2-dimethylaminomethyl-1-phenyl-2-propen-1-one; D000970:Antineoplastic Agents; D008352:Mannich Bases; D011427:Propiophenones; D014280:Triglycerides; D014508:Urea; D002784:Cholesterol; D003404:Creatinine