title: Ocular manifestation of disseminated Mycobacterium simiae infection in a cat.
abstract: Disseminated mycobacterial disease was diagnosed in an eight-year-old domestic shorthaired cat, with involvement of the skin, lungs, lymph nodes and one eye. Mycobacterium simiae was cultured from skin biopsies on solid agar and in liquid media. This organism is known to cause pulmonary, cutaneous or disseminated infection in human patients with acquired immunodeficiency syndrome but has never been encountered as a pathogen in companion animals. Combination treatment with rifampicin, enrofloxacin and clarithromycin resulted in complete clinical remission within six months, with no side effects. No recurrence was observed in a 22-month follow-up period.
authors.affiliation: Department of Small Animal Surgery (Ophthalmology), University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Dietrich
authors.forename: P
authors.initials: P
authors.lastname: Arnold
authors.forename: F
authors.initials: F
authors.lastname: Guscetti
authors.forename: G E
authors.initials: GE
authors.lastname: Pfyffer
authors.forename: B
authors.initials: B
authors.lastname: Spiess
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D002371:Cat Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D002415:Cats; D017291:Clarithromycin / Q000008:administration & dosage; D003937:Diagnosis, Differential; D003941:Diagnostic Techniques, Ophthalmological / Q000662:veterinary; D004359:Drug Therapy, Combination; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D008297:Male; D009161:Mycobacterium / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D015363:Quinolones / Q000008:administration & dosage; D011859:Radiography; D012293:Rifampin / Q000008:administration & dosage; D014392:Tuberculosis, Ocular / Q000209:etiology / Q000662:veterinary
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D017291:Clarithromycin; D012293:Rifampin