"The force be with you": ATP in gut mechanosensory transduction.
Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.
Cooke
Helen J
HJ
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA.
Wunderlich
Jacqueline
J
Christofi
Fievos L
FL
D000255:Adenosine Triphosphate / Q000737:chemistry*; D006801:Humans; D008465:Mechanoreceptors / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry; D015398:Signal Transduction / Q000502:physiology*
D009711:Nucleotides; D000255:Adenosine Triphosphate