[Lamotrigine in the treatment of pharmaco-resistant epilepsy in children].
Lamotrigine (LTG) is an antiepileptic drug whose therapeutic effect may be due to inhibition of the excitatory transmitter glutamate release. The aim of this study is to evaluate LTG efficacity and tolerability in the therapy of drug-resistant epilepsy in children. LTG is tested in 27 patients with different forms of epilepsy. Results show a satisfactory response and the low adverse effects of LTG in agreement with literature data. The therapy also improve cognitive function and relationship.
Diaconu
Georgeta
G
Facultatea de Medicină Clinica a III-a Pediatrie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Moraru
D
D
Grigore
Ioana
I
Frasin
Mariana
M
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D003196:Computer Graphics; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine