Do hemoglobin and hemocyanin impair schistosoma killing by no?
Nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa in definitive and intermediate hosts as well as in vectors. Here, we postulate that hemoglobin and hemocyanin may impair Schistosoma killing by NO in the definitive and intermediate hosts. Interestingly, hemoglobin, myoglobin, and neuroglobin may protect Plasmodium and Trypanosoma from the antiparasitic effects of NO.
Ascenzi
Paolo
P
Dipartimento di Biologia, Università Roma Tre, Roma, Italy. ascenzi@bio.uniroma3.it
Fasano
Mauro
M
Gradoni
Luigi
L
D000818:Animals; D006433:Hemocyanins / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000097:blood*; D012547:Schistosoma / Q000378:metabolism*; D012552:Schistosomiasis / Q000097:blood / Q000469:parasitology; D012556:Schistosomicides / Q000097:blood
D006454:Hemoglobins; D012556:Schistosomicides; D009569:Nitric Oxide; D006433:Hemocyanins