Heterogeneous Epstein-Barr virus latent gene expression in AIDS-associated lymphomas and in type I Burkitt's lymphoma cell lines.
Epstein-Barr virus (EBV) is associated with lymphoma in immunocompromised patients. This study provides evidence that the expression of EBV nuclear antigen-3 genes can be directed from the F promoter in different type I Burkitt's lymphoma cell lines and in some lymphomas from human immunodeficiency virus-infected patients. This expression occurs predominantly after induction of the EBV lytic cycle.
Touitou
R
R
INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France.
Arbach
H
H
INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France.
Cochet
C
C
INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France.
Feuillard
J
J
Hématologie Biologique, Hôpital Avicenne, EA 1625, UFR SMBH, Université Paris 13 Bobigny, France.
Martin
A
A
Hématologie Biologique, Hôpital Avicenne, EA 1625, UFR SMBH, Université Paris 13 Bobigny, France.
Raphaël
M
M
Hématologie Biologique, Hôpital Avicenne, EA 1625, UFR SMBH, Université Paris 13 Bobigny, France.
Joab
I
I
INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France.
D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000821:virology*; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D016483:Lymphoma, AIDS-Related / Q000821:virology*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017735:Virus Latency
D004279:DNA, Viral; C422762:EBNA-3B antigen; D019309:Epstein-Barr Virus Nuclear Antigens; D012333:RNA, Messenger