IL-10 gene polymorphism and herpesvirus infections.
Genetics has an important role in resistance to various infections and it also may modify the clinical picture of an infectious disease. Here, we briefly review our recent data demonstrating that the polymorphism of the IL-10 gene is associated with resistance to some common herpesviruses and, additionally, that this same gene is involved in the regulation of the severity of the infection and in the reactivation process.
Hurme
M
M
Department of Microbiology and Immunology, University of Tampere Medical School and University Hospital, FIN-33014 Tampere, Finland. mikko.hurme@uta.fi
Haanpää
M
M
Nurmikko
T
T
Wang
X-Y
XY
Virta
M
M
Pessi
T
T
Kilpinen
S
S
Hulkkonen
J
J
Helminen
M
M
D003586:Cytomegalovirus Infections / Q000235:genetics / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000276:immunology; D005838:Genotype; D006239:Haplotypes; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology; D006566:Herpesviridae Infections / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic
D016753:Interleukin-10