title: Selection events in directing B cell development.
abstract: Homeostasis in the B cell compartment (as well as in T cells) is controlled by tightly regulated selection events. Throughout their life span, B cells are subjected to selection signals determining not only developmental progression, but also maturation and survival. It is now clear that most of these signals require the expression of B cell antigen receptor (or preB receptor) with functional signaling capacity. The administration of numerous mutations into the mouse germline enabled us to identify several checkpoints along the B cell developmental pathway, and provided us with powerful experimental tools to probe for selection events regulating developmental progression. In here, we will discuss recent studies in this field.
authors.affiliation: Department of Immunology, Bruce Rappaport Faculty of Medicine and Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Seagal
authors.forename: D
authors.initials: D
authors.lastname: Melamed
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D006801:Humans; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology
chemical_list: D011947:Receptors, Antigen, B-Cell