A morphological and immunohistochemical investigation of guinea pig skin after the introduction of substance P and VIP.
The aim of this study was to examine a morphological picture of guinea pig skin that had been injected with neuropeptides (NPS)(2)- substance P (SP) and guinea pig vasoactive intestinal peptide (VIP) - to elucidate their local influence. Routine histological stainings were performed, together with immunohistochemical reactions for T cells and for macrophages. In the deeper layers of the skin, T cell and macrophagic infiltrations were observed. The intensity of these changes was greater 24 hours after injections than that observed at the third hour of the experiment.
Gendek-Kubiak
Hanna
H
Department of Histology and Embryology, Medical University of Łódź, Narutowicza 60, Poland. h_kubiak@hotmail.com
Danowski
Jacek
J
Kmieć
Bogumił L
BL
D000818:Animals; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D015213:Neuroimmunomodulation / Q000187:drug effects; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000276:immunology / Q000294:innervation; D013373:Substance P / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide