Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of Italy.
Oesophageal papillomas are known to occur in cattle infected with bovine papillomavirus type 4 (BPV-4), and BPV-4 papillomas may undergo malignant progression in cattle that feed on bracken fern. In the south of Italy, where bracken fern is common, examination of 1133 slaughterhouse cattle aged 4-12 years revealed oesophageal lesions (single or multiple peduncuolated proliferations, or mucosal thickening) in 147 (13%). These two types of lesion were consistent with exophytic and inverted papilloma, respectively. BPV-4 was detected by polymerase chain reaction (PCR) analysis in >60% of the samples in which oesophageal papilloma was diagnosed histopathologically. Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain.
Borzacchiello
G
G
Department of Pathology and Animal Health, General Pathology and Infectious Diseases Division, Faculty of Veterinary Medicine, Naples University Federico II, Rome, Italy
Ambrosio
V
V
Roperto
S
S
Poggiali
F
F
Tsirimonakis
E
E
Venuti
A
A
Campo
M S
MS
Roperto
F
F
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D052688:Bovine papillomavirus 1 / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D052697:Bovine papillomavirus 4; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D004938:Esophageal Neoplasms / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D010212:Papilloma / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*
D004273:DNA, Neoplasm; D004279:DNA, Viral