Application of genomics to toxicology research.
Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.
Thomas
Russell S
RS
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin, USA. rthomas@kalypsys.com
Rank
David R
DR
Penn
Sharron G
SG
Zastrow
Gina M
GM
Hayes
Kevin R
KR
Hu
Tianhua
T
Pande
Kalyan
K
Lewis
Mark
M
Jovanovich
Stevan B
SB
Bradfield
Christopher A
CA
D000818:Animals; D004195:Disease Models, Animal; D004785:Environmental Pollutants / Q000009:adverse effects; D005544:Forecasting; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D018675:Toxicity Tests; D014116:Toxicology / Q000639:trends*
D004785:Environmental Pollutants