Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma.
In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.
Fujii
Keiko
K
Department of Medicine, University of Okayama, Okayama, Japan.
Ishimaru
Fumihiko
F
Nakase
Koichi
K
Tabayashi
Takayuki
T
Kozuka
Teruhiko
T
Naoki
Kyoko
K
Miyahara
Masayuki
M
Toki
Hironobu
H
Kitajima
Koichi
K
Harada
Mine
M
Tanimoto
Mitsune
M
D015139:Blotting, Southern; D002353:Carrier State; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D017353:Gene Deletion; D015490:HTLV-I Infections / Q000235:genetics; D006801:Humans; D051740:Ikaros Transcription Factor; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C111431:IKZF2 protein, human; D020033:Protein Isoforms; D014157:Transcription Factors; D051740:Ikaros Transcription Factor