title: The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
abstract: Pharmacological studies were conducted with the hexane extract of the dry stem of Diospyros variegata Kruz. (Ebenaceae) on experimental animals for evaluating the analgesic, antipyretic and anti-inflammatory activities. In the analgesic test, the hexane extract elicited inhibitory intensity on acetic acid-induced writhing response and on the late phase of formalin test but possessed only a weak effect on the tail-flick response and on the early phase of formalin test. The hexane extract also elicited antipyretic action when tested in yeast-induced hyperthermia in rats. In addition, the hexane extract showed an anti-inflammatory effect when tested in ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced rat ear edema.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Trongsakul
authors.forename: A
authors.initials: A
authors.lastname: Panthong
authors.forename: D
authors.initials: D
authors.lastname: Kanjanapothi
authors.forename: T
authors.initials: T
authors.lastname: Taesotikul
mesh_terms: D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D029788:Diospyros / Q000737:chemistry*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D005557:Formaldehyde; D006586:Hexanes; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D000432:Methanol; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D012997:Solvents
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D009020:Morphine; D010653:Phenylbutazone; D019342:Acetic Acid; D001241:Aspirin; D000432:Methanol