[Clinical characterization of interleukin-8 in patients with idiopathic pulmonary fibrosis].
The levels of interleukin-8 (IL-8) in the serum, bronchoalveolar fluid (BALF) and epithelial lining fluid (ELF) were measured in patients with idiopathic pulmonary fibrosis. (IPF), in order to evaluate the clinical significance of IL-8. The serum levels were significantly higher in patients with active IPF (34.4 +/- 11.9 pg/ml, n = 8) than in those with stable IPF (mean: 14.6 +/- 10.9 pg/ml, n = 18), but neither correlated with the serum level of KL-6 or of SP-D, or with the intensity of chest Ga67-scintigraphy. There were no significant differences in BALF or ELF IL-8 levels between the active and stable IPF groups. These results suggest that the serum level of IL-8 is a useful marker for evaluating the disease activity in patients with IPF.
Totani
Yoshitaka
Y
Division of Respirology & Allergology, Department of Internal Medicine, School of Medicine, Fujita Health University, Kutsukake-Cho, Toyoake City, Aichi 470-1192, Japan.
Saitoh
Yuji
Y
Sakakibara
Hiroki
H
Miyamori
Isamu
I
Ishizaki
Takeshi
T
D000368:Aged; D001826:Body Fluids / Q000737:chemistry; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology
D016209:Interleukin-8