[Efficacy of anti-inflammatory treatment with benacort in exacerbations of chronic obstructive lung disease].
OBJECTIVE
To determine a course and prognostic effectiveness of corticosteroid therapy of chronic obstructive pulmonary disease (COPD).


METHODS
Long-term therapy with broncholytics (berodual) and benacort was given to 25 patients in non-infectious exacerbation, 20 patients received broncholitics of 45 COPD patients with mild and moderate ventilation disorders. Follow-up lasted for 2.5 years. Treatment effectiveness was judged by clinical indices, external respiration function, parameters of systemic immunity, cytogram of induced sputum and concentration of inflammatory markers in the sputum.


RESULTS
An immediate effect of two-month therapy with benacort of COPD exacerbations manifested with positive clinical dynamics and relief of endobronchial inflammation. Prognostic efficacy--with a significant reduction of the frequency of COPD exacerbations and of their mean duration more than 3-fold.


CONCLUSIONS
The results of long-term follow-up support validity of inhalation corticosteroids use for eradication and prevention of noninfectious exacerbations of COPD.
Kolesnikov
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VV
Korol'chuk
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IS
D000208:Acute Disease; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D013256:Steroids; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D013256:Steroids