The CD95(APO-1/Fas) DISC and beyond.
CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.
Peter
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The Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA. mpeter@uchicago.edu
Krammer
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D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D053418:Death Domain Receptor Signaling Adaptor Proteins; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D019014:fas Receptor / Q000378:metabolism*
D053418:Death Domain Receptor Signaling Adaptor Proteins; D046911:Macromolecular Substances; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; D020169:Caspases