title: P38 mitogen-activated protein kinase influence on the production of IL-10 in human schistosomiasis mansoni.
abstract: Schistosomiasis mansoni remains a significant public health problem in many parts of the tropics and subtropics. Clinical manifestations range from the asymptomatic intestinal form through to the hepatosplenic form of the disease, a potentially lethal clinical condition in a subsection of the exposed population. In this study, we investigated the mechanisms by which interleukin (IL)-10 production could be differentially controlled in patients with the intestinal and hepatosplenic forms of the disease, as IL-10 may play a fundamental role in the development of the hepatosplenic disease state. It is reported that p38 mitogen-activated protein (MAP) kinase signalling, and in particular p38 MAPK activation, is central to IL-10 production of cells from patients with schistosomiasis. Furthermore, the difference in the levels of activated p38 MAPK and the activation transcription factor (ATF-2), may explain the difference in the amount of IL-10 produced by cells from intestinal and hepatosplenic patients. We suggest that the type of immune response triggered in patients with hepatosplenomegaly could be influenced by the levels of phosphorylated p38 MAPK.
authors.affiliation: Division of Infection and Immunity, Joseph Black Building, IBLS, University of Glasgow, Glasgow, UK. pcarneir@udcf.gla.ac.uk
authors.forename: Patricia
authors.initials: P
authors.lastname: Carneiro-Santos
authors.forename: Lucia F
authors.initials: LF
authors.lastname: Alves-Oliveira
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
authors.forename: Paul
authors.initials: P
authors.lastname: Hagan
mesh_terms: D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004789:Enzyme Activation; D006529:Hepatomegaly / Q000276:immunology / Q000469:parasitology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis*; D008875:Middle Aged; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology*; D015398:Signal Transduction; D013163:Splenomegaly / Q000276:immunology / Q000469:parasitology; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D000947:Antigens, Helminth; D016753:Interleukin-10; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases