title: Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia.
abstract: Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6+7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD.
authors.affiliation: Department of Clinical Neuroscience, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. annica.johansson@clinchem.gu.se
authors.forename: A
authors.initials: A
authors.lastname: Johansson
authors.forename: H
authors.initials: H
authors.lastname: Hampel
authors.forename: F
authors.initials: F
authors.lastname: Faltraco
authors.forename: K
authors.initials: K
authors.lastname: Buerger
authors.forename: L
authors.initials: L
authors.lastname: Minthon
authors.forename: N
authors.initials: N
authors.lastname: Bogdanovic
authors.forename: M
authors.initials: M
authors.lastname: Sjögren
authors.forename: H
authors.initials: H
authors.lastname: Zetterberg
authors.forename: L
authors.initials: L
authors.lastname: Forsell
authors.forename: L
authors.initials: L
authors.lastname: Lilius
authors.forename: L O
authors.initials: LO
authors.lastname: Wahlund
authors.forename: L
authors.initials: L
authors.lastname: Rymo
authors.forename: J A
authors.initials: JA
authors.lastname: Prince
authors.forename: K
authors.initials: K
authors.lastname: Blennow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016203:CDC2 Protein Kinase / Q000235:genetics*; D002455:Cell Division / Q000235:genetics; D003704:Dementia / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D016203:CDC2 Protein Kinase