title: Neuropsychological manifestations in a case of bilateral thalamic infarction.
abstract: Neuropsychological manifestation has been reported with lesions of the anterior and non-specific thalamic nuclei and mammilothalamic tract (MMT). These have been reported in the setting of arterial infarction and/or haemorrhage. Cerebral venous sinus thrombosis (CVT) is a rare cause of brain infarction. It occurs in the setting of oral contraceptive administration or pregnancy. Inherited thrombophilias are documented risk factors. The most frequent being heterozygous factor V Leiden mutation. We report a single case of bilateral thalamic infarction due to cerebral vein and sinus thrombosis. Clinically the case manifested with memory impairment and dysexecutive symptoms. Predisposing factor for venous thrombosis was a homozygous factor V Leiden mutation. The patient was treated with anticoagulation and made a good recovery.
authors.affiliation: Concord Repatriation and General Hospital, Hospital Road, Concord, Sydney, Australia. vucic2@bigpond.com
authors.forename: S
authors.initials: S
authors.lastname: Vucic
authors.forename: T
authors.initials: T
authors.lastname: Lye
authors.forename: R A
authors.initials: RA
authors.lastname: Mackenzie
mesh_terms: D000328:Adult; D020520:Brain Infarction / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*; D015898:Tomography Scanners, X-Ray Computed; D014705:Verbal Behavior / Q000502:physiology