[On parametric stability of gene networks controlling ontogenetic processes].
The problem of evaluating the parametric stability of three models of pro- and eukaryotic gene networks controlling ontogenetic processes has been defined and solved. Experimental plans of testing gene networks for parametric stability based on the method of generalized threshold models were developed and realized as a software application. We examined the "sensitivity" of the functioning modes to random variations of the parameters in the three model systems: the system of developmental control of phage lambda, the subsystem of morphogenetic control of Arabidopsis thaliana flower, and the gene subnetwork controlling early ontogeny in Drosophila melanogaster. The parametric stability was quantitatively assessed for these models.
Churaev
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RN
Institute of Biology, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054 Russia. tchuraev@anrb.ru
Galimzianov
A V
AV
D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development; D010582:Bacteriophage lambda / Q000235:genetics; D003198:Computer Simulation; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D008957:Models, Genetic