[Administration of the omega-3 polyunsaturated fatty acid drug eiferol decreases alcohol motivation in albino rats by elevating the level of antibodies to alcohol dehydrogenase].
The study experimentally assessed the approach proposed by the authors to lower alcohol motivation, which involves enhancement of a specific immunity at the stage of alcoholization when acetaldehydemodified ethanol exchange enzymes [alcohol dehydrogenase (ADH)] and acetaldehyde dehydrogenase may be expected to occur. Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver. At the same time, PUFA drugs can, under certain conditions, produce an anti-alcoholic activity and a positive effect on the psychoemotional status of animals after the ethanol deprivation period.
Isaev
V A
VA
Danilova
R A
RA
Lovat'
M L
ML
Kushnir
E A
EA
Moskvitina
T A
TA
Obukhova
M F
MF
Shmal'gauzen
E V
EV
Ashmarin
I P
IP
D000426:Alcohol Dehydrogenase / Q000187:drug effects* / Q000276:immunology; D000445:Aldehyde Oxidoreductases / Q000187:drug effects / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood* / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D000431:Ethanol / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009042:Motivation; D004364:Pharmaceutical Preparations; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000201:enzymology
D000906:Antibodies; D015525:Fatty Acids, Omega-3; D004364:Pharmaceutical Preparations; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+)