title: Genetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis.
abstract: Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.
authors.affiliation: Unidad de Genética Bacteriana (Consejo Superior de Investigaciones Científicas), Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. agcampa@isciii.es
authors.forename: Adela G
authors.initials: AG
authors.lastname: de la Campa
authors.forename: María-José
authors.initials: MJ
authors.lastname: Ferrandiz
authors.forename: Fe
authors.initials: F
authors.lastname: Tubau
authors.forename: Román
authors.initials: R
authors.lastname: Pallarés
authors.forename: Federico
authors.initials: F
authors.lastname: Manresa
authors.forename: Josefina
authors.initials: J
authors.lastname: Liñares
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001987:Bronchiectasis / Q000188:drug therapy* / Q000382:microbiology; D002939:Ciprofloxacin / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin