title: Multicentric occurrence of hepatocellular carcinoma in patients with a somatic mutation of mitochondorial DNA and hepatitis C virus.
abstract: The relationship between the multicentric occurrence of hepatocellular carcinoma (HCC) and the frequency of mutation of mitochondrial DNA (mtDNA) in the noncancerous hepatic tissue in patients infected with hepatitis C virus was investigated. Of the 48 patients, multicentric occurrence of HCC was found in ten of 33 patients with three or more mutations in the mtDNA, whereas no patients had multicentric HCCs in 15 patients with two or fewer mutations in the mtDNA (P=0.0201). A high rate of mtDNA mutation in noncancerous hepatic tissue may be related to multicentric hepatocarcinogenesis and the hypercarcinogenic state in such patients.
authors.affiliation: Department of Gastroenterological and Hepato-biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan
authors.forename: Shoji
authors.initials: S
authors.lastname: Kubo
authors.forename: Manabu
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hirohashi
authors.forename: Hiromu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Taichi
authors.initials: T
authors.lastname: Shuto
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tamori
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Masayasu
authors.initials: M
authors.lastname: Inoue
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nishiguchi