Urachal adenocarcinoma metastatic to the ovaries: case report and literature review.
We report a urachal adenocarcinoma metastatic to both ovaries in a 50-year-old Japanese woman. Pelvic examination and imaging studies revealed a large cystic tumor occupying the pelvis and another cystic tumor between the umbilicus and the urinary bladder. A laparotomy was performed. Histopathological examination revealed a urachal tumor that was a well-differentiated invasive mucinous adenocarcinoma; the overlying urothelium was intact. The right and left ovarian tumors were well-differentiated mucinous adenocarcinomas. The urachal and ovarian tumors were immunoreactive for cytokeratin 20 and carcinoembryonic antigen, but negative for cytokeratin 7. The patient is alive with lymph node and bone metastases 6 months postoperatively. This is the eighth reported case of an adenocarcinoma of the bladder with ovarian metastasis.
Ohira
Satoshi
S
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
Shiohara
Shigeki
S
Itoh
Kazuko
K
Ashida
Takashi
T
Fukushima
Mana
M
Konishi
Ikuo
I
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000556:secondary*; D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism; D008207:Lymphatic Metastasis / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000556:secondary*; D014497:Urachus / Q000378:metabolism / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins