title: [Evaluation of multi-modality treatment for the patients with advanced esophageal cancer].
abstract: Hyperthermia has been proved to be intensely cytotoxic to malignant cells when combined with anticancer agents and irradiation. We have applied hyperthermo-chemo-radio-therapy (HCR) using a radiofrequency system with an endotract electrode to the patients with advanced esophageal cancer. In this study, 132 patients with advanced esophageal cancer with invasion to the neighboring structures, who underwent non-curative operation, were analysed. The markedly effective cases was observed in 12.2% in HCR group, while in 2.5% in chemoradiotherapy (CR) group, microscopically. The survival rate of the HCR group was significantly better than that of the CR group (p < 0.05). Pre- and post-operative leukocytopenia caused by preoperative treatment was not found to be a risk factor of postoperative complication. It is important to continue to clarify the factors influencing the effectiveness of preoperative HCR in the future. We hope that HCR will play an even more important role in treatment of esophageal cancer.
authors.affiliation: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saeki
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ohga
authors.forename: Shuhei
authors.initials: S
authors.lastname: Ito
authors.forename: Motonori
authors.initials: M
authors.lastname: Futatsugi
authors.forename: Yasue
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kakeji
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shioyama
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy; D006801:Humans; D006979:Hyperthermia, Induced; D007902:Length of Stay; D007970:Leukopenia / Q000209:etiology; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate