title: Monoclonal anti-idiotypic antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicits antigen-specific humoral and cellular immune responses in colorectal cancer patients.
abstract: Monoclonal rat anti-idiotypic antibody (Ab2) BR3E4 mimicking the colorectal carcinoma (CRC)-associated epitope CO17-1A induced antigen-specific humoral and cellular immune responses in mice and rabbits. Ab2 BR3E4 was administered in a phase I trial to CRC patients either as intact IgG or as F(ab')(2) coupled to keyhole limpet hemocyanin (KLH). There was a trend for the F(ab')(2)-KLH-immunized patients to show higher immune response rates (18/21 and 5/15 patients with anti-anti-idiotypic antibodies and T cells, respectively) than the IgG-immunized patients (15/23 and 3/15 patients positive). Clinical responses were rare in these patients with liver metastases.
authors.affiliation: The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Birebent
authors.forename: Edith
authors.initials: E
authors.lastname: Mitchell
authors.forename: Nese
authors.initials: N
authors.lastname: Akis
authors.forename: Weiping
authors.initials: W
authors.lastname: Li
authors.forename: Rajasekharan
authors.initials: R
authors.lastname: Somasundaram
authors.forename: Enkhtsetseg
authors.initials: E
authors.lastname: Purev
authors.forename: Diane
authors.initials: D
authors.lastname: Hoey
authors.forename: Michael
authors.initials: M
authors.lastname: Mastrangelo
authors.forename: Henry
authors.initials: H
authors.lastname: Maguire
authors.forename: David T
authors.initials: DT
authors.lastname: Harris
authors.forename: Sridhar
authors.initials: S
authors.lastname: Nair
authors.forename: Dewei
authors.initials: D
authors.lastname: Cai
authors.forename: Tianqian
authors.initials: T
authors.lastname: Zhang
authors.forename: Dorothee M
authors.initials: DM
authors.lastname: Herlyn
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000627:therapeutic use; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000276:immunology*; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G; C050928:carcinoma-associated antigen 17-1A; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin