Soluble polymer-supported convergent parallel library synthesis.
Soluble polymer-supported convergent synthesis has for the first time been successfully exploited for parallel library synthesis; sub-libraries of tripeptide iodoarenes and arylboronic acids reacted smoothly in a multipolymer PdII-catalyzed Suzuki coupling reaction to generate a library of bisaryl-linked hexapeptides.
Ahn
Jung-Mo
JM
Department of Chemistry, The Scripps Research Institute and Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Wentworth
Paul
P
Janda
Kim D
KD
D020650:Combinatorial Chemistry Techniques; D009842:Oligopeptides / Q000138:chemical synthesis*; D019151:Peptide Library; D011108:Polymers / Q000737:chemistry; D012995:Solubility
D009842:Oligopeptides; D019151:Peptide Library; D011108:Polymers