title: Syndromic incidence of ovarian carcinoma after liver transplantation, with special reference to anteceding breast cancer.
abstract: Ovarian cancer is the gynecologic malignancy with the highest number of deaths in the United States. Previous studies had found a decreased incidence of female gynecological malignancies after liver transplantation. In order to estimate the incidence of ovarian carcinoma after liver transplantation, we evaluated 1708 consecutive liver transplant recipients from 1984 to 2001. Of them, 770 (43%) were female. Routine follow-ups were performed at 1, 2, 5, and 10 years after transplantation. There were two cases of ovarian carcinoma. Both occurred in recipients with a previous history of breast cancer. Based on these data, we conclude that the incidence of ovarian cancer is 1:385 among all female liver transplant recipients, and 1:6.5 among those with a history of pretransplant breast cancer. We recommend that regular check-ups should be undertaken, especially in the population at highest risk.
authors.affiliation: Baylor University Medical Center, Transplant Services, 3500 Gaston Avenue, Dallas, Texas 75246, USA.
authors.forename: Ernesto P
authors.initials: EP
authors.lastname: Molmenti
authors.forename: Hebe
authors.initials: H
authors.lastname: Molmenti
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Weinstein
authors.forename: Eric E
authors.initials: EE
authors.lastname: Elliott
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Fasola
authors.forename: Douglas
authors.initials: D
authors.lastname: Orr
authors.forename: Joann
authors.initials: J
authors.lastname: Blum
authors.forename: Daniel
authors.initials: D
authors.lastname: Savino
authors.forename: W Mark
authors.initials: WM
authors.lastname: Hamilton
authors.forename: Robert M
authors.initials: RM
authors.lastname: Goldstein
authors.forename: Marlon F
authors.initials: MF
authors.lastname: Levy
authors.forename: Goran B
authors.initials: GB
authors.lastname: Klintmalm
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D016031:Liver Transplantation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents