title: Pyridazinones as selective cyclooxygenase-2 inhibitors.
abstract: Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8. chunsing_li@merck.com
authors.forename: Chun Sing
authors.initials: CS
authors.lastname: Li
authors.forename: Christine
authors.initials: C
authors.lastname: Brideau
authors.forename: Chi Chung
authors.initials: CC
authors.lastname: Chan
authors.forename: Chantal
authors.initials: C
authors.lastname: Savoie
authors.forename: David
authors.initials: D
authors.lastname: Claveau
authors.forename: Stella
authors.initials: S
authors.lastname: Charleson
authors.forename: Robert
authors.initials: R
authors.lastname: Gordon
authors.forename: Gillian
authors.initials: G
authors.lastname: Greig
authors.forename: Jacques Yves
authors.initials: JY
authors.lastname: Gauthier
authors.forename: Cheuk K
authors.initials: CK
authors.lastname: Lau
authors.forename: Denis
authors.initials: D
authors.lastname: Riendeau
authors.forename: Michel
authors.initials: M
authors.lastname: Thérien
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wong
authors.forename: Petpiboon
authors.initials: P
authors.lastname: Prasit
mesh_terms: D000818:Animals; D002460:Cell Line; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D006801:Humans; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008565:Membrane Proteins; D008657:Metabolic Clearance Rate; D011451:Prostaglandin-Endoperoxide Synthases; D011724:Pyridazines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D011724:Pyridazines; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat