[Platelet adhesion and antioxidant therapy in experimental stress].
We have investigated the platelet activity, by platelet adhesion index and the end products of lipid peroxidation--MDA. Platelet adhesion index was established using Rovatti's method. Determinations were carried out on experimental model consisting of five groups of white male Wistar rats. In the vitamin E supplemented group, the platelet adhesion index was constantly correlated with MDA level. Thus there is a correlation between the intensity of the oxidative stress and vitamin E supplementation. The imbalance between pro- and antioxdants in experimental stress may enhance the platelet adhesion via arachidonic acid metabolism and endoperoxides formation. Steady administration of vitamin E in the experimental stress, due to its antioxidant properties, causes the progressive decrease of peroxidation and of platelet adhesion.
Ciocoiu
Manuela
M
Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Bădescu
Magda
M
Păduraru
Ioana
I
Colev-Luca
Veronica
V
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D003196:Computer Graphics; D004195:Disease Models, Animal; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy*; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde