title: Pediatric quetiapine overdose: a case report and literature review.
abstract: Quetiapine is a medication approved for the treatment of psychotic disorders in adults. At this time it is not approved for the treatment of children or adolescents. It is an atypical antipsychotic agent that is efficacious in treating both the positive and negative symptoms of schizophrenia. There is currently little information available concerning the safety of quetiapine in overdose, and there are no previous case reports of quetiapine overdose in the pediatric population. We present the case of a 15-year-old girl who ingested 1250 mg of quetiapine (21.6 mg/kg) in a suicide attempt. She developed multiple symptoms including tachycardia, agitation, hypotension, and unconsciousness. We compare her symptoms to previous adult cases of quetiapine overdose and review overdose treatment recommendations. We also examine clinical situations that may lead to a more severe clinical course.
authors.affiliation: Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida 33613, USA. gcatalan@hsc.usf.edu
authors.forename: Glenn
authors.initials: G
authors.lastname: Catalano
authors.forename: Maria C
authors.initials: MC
authors.lastname: Catalano
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Agustines
authors.forename: Erin M
authors.initials: EM
authors.lastname: Dolan
authors.forename: Khatija N
authors.initials: KN
authors.lastname: Paperwalla
mesh_terms: D000293:Adolescent; D017109:Akathisia, Drug-Induced / Q000523:psychology; D014150:Antipsychotic Agents / Q000506:poisoning* / Q000627:therapeutic use; D001519:Behavior / Q000187:drug effects; D003987:Dibenzothiazepines / Q000506:poisoning* / Q000627:therapeutic use; D005260:Female; D015600:Glasgow Coma Scale; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D013406:Suicide, Attempted
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate