Modern approaches to drug discovery and design: setting the scene.
The raison d'ítre for the drug discovery and development process is to provide safe and effective treatments for diseases. Bringing a new drug to market, however, is a time-consuming and expensive process and it remains an imperative for drug companies that they identify ways in which they can accelerate the identification of potential targets and their screening and development in order to maintain a competitive edge. Successful drug discovery efforts include biochemical, biophysical, genetic and immunological approaches, targeting such processes as signal transduction, cell cycle control, apoptosis, gene regulation and metastasis. As the number of these biological targets increases, reliance on bioinformatics and chemoinformatics to improve decision making, by identifying characteristics of successful drugs and sharing knowledge gained within the scientific community, has become a burgeoning area in the post-genomic era of drug discovery.
Kelly
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DE
Wolfson Laboratory of P450 Biodiversity, University of Wales Aberystwyth, Edward Llwyd Building, Penglais, Aberystwyth SY23 3DA, Wales, U.K. dek@aber.ac.uk
Clark
A
A
D015195:Drug Design; D023281:Genomics / Q000379:methods; D006801:Humans; D015394:Molecular Structure; D011485:Protein Binding