Identification of mammalian orthologs associates PYPAF5 with distinct functional roles.
PYRIN- and CARD-containing proteins belong to a recently identified protein family involved in the regulation of apoptosis and inflammatory processes. Variations in the gene products of the family members PYPAF1 and NOD2/CARD15 have been associated with several autoinflammatory diseases. We could identify the mouse orthologs of PYPAF1, PYPAF5, NOD1, NOD2 and the rat ortholog of PYPAF5. Intriguingly, we found that PYPAF5 has been reported previously not only as regulator of NF-kappaB and caspase-1, but also as angiotensin II and vasopressin receptor. In particular, based on a comprehensive sequence analysis, we propose a structural model for this hormone receptor that is different from the model suggested previously.
Albrecht
Mario
M
Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany. mario.albrecht@mpi-sb.mpg.de
Domingues
Francisco S
FS
Schreiber
Stefan
S
Lengauer
Thomas
T
D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C468563:NLRP6 protein, human