Cerebral blood flow changes induced by subthalamic stimulation in Parkinson's disease.
The authors used PET to show that the abnormal pattern of cerebral blood flow (CBF) activation described in PD is normalized by electrical stimulation of subthalamic nucleus. Improvement in bradykinesia correlated with increase in CBF due to stimulation in the supplementary motor area and anterior cingulate cortex. Compared to unilateral stimulation, bilateral stimulation induced a greater extent of activation in bilateral cortical areas and additional bilateral activation of globus pallidus.
Strafella
Antonio P
AP
Montreal Neurological Institute, McGill University, Montréal, Québec, Canada.
Dagher
Alain
A
Sadikot
Abbas F
AF
D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D011597:Psychomotor Performance; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D014055:Tomography, Emission-Computed