Palladium-catalyzed enantioselective oxidation of alcohols: a dramatic rate acceleration by Cs2CO3/t-BuOH.
[reaction: see text] The addition of Cs(2)CO(3) and t-BuOH provides a dramatic rate acceleration in the palladium-catalyzed aerobic oxidative kinetic resolution of secondary alcohols while maintaining the selectivity of the process.
Bagdanoff
Jeffrey T
JT
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Ferreira
Eric M
EM
Stoltz
Brian M
BM
D000438:Alcohols / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D002586:Cesium / Q000737:chemistry*; D007700:Kinetics; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D020002:tert-Butyl Alcohol / Q000737:chemistry
D000438:Alcohols; D002254:Carbonates; D002586:Cesium; D010165:Palladium; D020002:tert-Butyl Alcohol