Characterization and pharmacological actions of tecostanine, an alkaloid of Tecoma stans.
Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.
Costantino
L
L
Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Italy. costantino.luca@unimo.it
Lins
A P
AP
Barlocco
D
D
Celotti
F
F
el-Abady
S A
SA
Brunetti
T
T
Maggi
R
R
Antolini
L
L
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008800:Mexico; D008958:Models, Molecular; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
D000470:Alkaloids; D007004:Hypoglycemic Agents; D011978:Receptors, Nicotinic; D011957:Receptors, Opioid; D013729:Terpenes; C472748:tecostanine