[Molecular basis of the t(1;22)(p13;q13) specific for human acute megakaryoblastic leukemia].
The t(1;22)(p13;q13) translocation is specifically associated with infant acute megakaryoblastic leukemia (M7). We have recently characterized the two genes involved in this translocation: OTT (One Two Two) and MAL (Megakaryoblastic Acute Leukemia) respectively located on chromosome 1 and 22. The t(1;22) translocation results in the fusion of these genes in all the cases studied to date. We summarize here present knowledge regarding this translocation.
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Inserm EMI 0210, 27, rue Juliette-Dodu, 75010, Paris, France.
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D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D014178:Translocation, Genetic