title: Dynamics of competitive evolution on a smooth landscape.
abstract: We study competitive DNA sequence evolution directed by in vitro protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and eventually reaches equilibrium. We explain this dynamical behavior within a continuum mean-field framework. Analytical results obtained on the motion of the pulse agree with simulations. Furthermore, finite population correction to the mean-field results are found to be insignificant.
authors.affiliation: Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California 92093-0319, USA.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Peng
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gerland
authors.forename: Terence
authors.initials: T
authors.lastname: Hwa
authors.forename: Herbert
authors.initials: H
authors.lastname: Levine
mesh_terms: D001667:Binding, Competitive; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D019143:Evolution, Molecular; D006657:Histones / Q000378:metabolism; D007700:Kinetics; D008957:Models, Genetic; D017354:Point Mutation; D011485:Protein Binding; D013816:Thermodynamics
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; D004247:DNA