title: Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey.
abstract: Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNA(Ser(UCN)) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three deaf children with A1555G (1.8%) but no examples of A7445G. One proband with the mitochondrial A1555G mutation has also evidence for right parietal infarct on a brain imaging study, for which common thrombotic mutations were found to be negative.
  
  
  CONCLUSIONS
  This study shows that the mitochondrial A1555G mutation is among the significant causes of prelingual non-syndromic deafness in the Turkish population.
authors.affiliation: Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey. mtekin@medicine.ankara.edu.tr.|Birlik Mah 8. Cadde No 8/3, Çankaya, 06610, Ankara, Turkey. mtekin@medicine.ankara.edu.tr.
authors.forename: M
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Duman
authors.affiliation: Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Boğoçlu
authors.affiliation: Dept. of ENT, Ankara Social Security Hospital, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: İncesulu
authors.affiliation: Dept. of Pediatrics, Suleyman Demirel University School of Medicine, Isparta, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Çomak
authors.affiliation: Dept. of Radiodiagnostics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Fitoz
authors.affiliation: Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yılmaz
authors.affiliation: Dept. of Pediatrics, Suleyman Demirel University School of Medicine, Isparta, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: İlhan
authors.affiliation: Division of Pediatric Molecular Pathology and Genetics, Ankara University School of Medicine, Dikimevi, 06100, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Akar
mesh_terms: D000293:Adolescent; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics*; D003638:Deafness / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial