Molecular communication between androgen receptor and general transcription machinery.
The androgen-androgen receptor (AR) signaling pathway plays a key role in proper development and function of male reproductive organs. Like other transcriptional regulators, AR may communicate with the general transcription machinery on the core promoter to exert its function as a transcriptional modulator. The molecular communication between AR and the general transcription machinery may be achieved either by the direct protein-protein interaction between AR and the general transcription machinery or by the indirect interaction mediated by coregulators. Analyses of AR-mediated transcription suggest that the orchestrated interaction of AR with the transcription factors IIF (TFIIF) and IIH (TFIIH), and positive transcription elongation factor b (P-TEFb), may increase efficiency of transcriptional elongation from the androgen target genes, such as prostate specific antigen (PSA). Based on studies so far, AR may regulate transcription not by enhanced assembly of preinitiation transcription complex but by regulating promoter clearance and elongation stage of transcription.
Lee
Dong Kun
DK
George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, 601 Elmwood Avenue, P.O. Box 626, Rochester 14642, NY, USA.
Chang
Chawnshang
C
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D008297:Male; D008954:Models, Biological; D042925:Positive Transcriptional Elongation Factor B; D011401:Promoter Regions, Genetic; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012319:RNA Polymerase II / Q000378:metabolism; D011944:Receptors, Androgen / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D051758:Transcription Factor TFIIH; D019473:Transcription Factors, TFII / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D011944:Receptors, Androgen; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II; D017430:Prostate-Specific Antigen; C056604:transcription factor TFIIF