title: Effect of microgravity on plasma catecholamine responses to stressors during space flight.
abstract: The effect of microgravity on the sympathicoadrenal system (SAS) activity in humans and animals has not yet been clarified. Our previous studies suggested that the SAS activity, evaluated by circulating and/or urinary catecholamine (CA) levels in astronauts during space flights, was found to be rather unchanged. However, CA levels were measured in astronauts only at rest conditions. The aim of the present study was to investigate effect of microgravity during space flight and post-flight readaptation on responsiveness of the SAS to somatic and psychic stressors evaluated by levels of catecholamines and their metabolite in the blood of the Slovak cosmonaut during his stay on board the space station Mir.
authors.affiliation: Institute of Experimental Endocrinology, SAS, Bratislava, Slovakia.
authors.forename: R
authors.initials: R
authors.lastname: Kvetnansky
authors.forename: L
authors.initials: L
authors.lastname: Macho
authors.forename: J
authors.initials: J
authors.lastname: Koska
authors.forename: K
authors.initials: K
authors.lastname: Pacak
authors.forename: T
authors.initials: T
authors.lastname: Hoff
authors.forename: L
authors.initials: L
authors.lastname: Ksinantova
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: E
authors.initials: E
authors.lastname: Kobzev
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
authors.forename: M
authors.initials: M
authors.lastname: Vigas
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D004837:Epinephrine / Q000097:blood / Q000378:metabolism*; D005080:Exercise Test; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D013026:Space Flight; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism; D014893:Weightlessness
chemical_list: D008734:Methoxyhydroxyphenylglycol; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine; D004837:Epinephrine