title: GPCR-GRAPA-LIB--a refined library of hidden Markov Models for annotating GPCRs.
abstract: GPCR-GRAPA-LIB is a library of HMMs describing G protein coupled receptor families. These families are initially defined by class of receptor ligand, with divergent families divided into subfamilies using phylogenic analysis and knowledge of GPCR function. Protein sequences are applied to the models with the GRAPA curve-based selection criteria. RefSeq sequences for Homo sapiens, Drosophila melanogaster, and Caenorhabditis elegans have been annotated using this approach.
authors.affiliation: Affymetrix Corporation, Bioinformatics, 6550 Vallejo Street, Suite 100 Emeryville, CA 94608, USA. ron_shigeta@affymetrix.com
authors.forename: Ron
authors.initials: R
authors.lastname: Shigeta
authors.forename: Melissa
authors.initials: M
authors.lastname: Cline
authors.forename: Guoying
authors.initials: G
authors.lastname: Liu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Siani-Rose
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D030562:Databases, Protein; D004282:Documentation; D019143:Evolution, Molecular; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D013329:Structure-Activity Relationship
chemical_list: D019204:GTP-Binding Proteins