An overview of the Notch signalling pathway.
The Notch receptor plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. Four Notch homologues have been identified in the human genome and aberrant Notch function has been associated with a number of human diseases. An intriguing pathway of Notch signalling has been elucidated involving multiple proteolytic steps and this pathway offers several targets for potential therapeutic intervention. While a consensus model has emerged, in the details there is much that is contentious. This review will primarily focus on our current understanding of the proteolytic events involved in generating and regulating Notch signalling.
Baron
Martin
M
School of Biological Sciences, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT, UK. mbaron@man.ac.uk
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D051880:Receptors, Notch; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D008565:Membrane Proteins; D051880:Receptors, Notch