title: Do hemoglobin and hemocyanin impair schistosoma killing by no?
abstract: Nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa in definitive and intermediate hosts as well as in vectors. Here, we postulate that hemoglobin and hemocyanin may impair Schistosoma killing by NO in the definitive and intermediate hosts. Interestingly, hemoglobin, myoglobin, and neuroglobin may protect Plasmodium and Trypanosoma from the antiparasitic effects of NO.
authors.affiliation: Dipartimento di Biologia, Università Roma Tre, Roma, Italy. ascenzi@bio.uniroma3.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Ascenzi
authors.forename: Mauro
authors.initials: M
authors.lastname: Fasano
authors.forename: Luigi
authors.initials: L
authors.lastname: Gradoni
mesh_terms: D000818:Animals; D006433:Hemocyanins / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000097:blood*; D012547:Schistosoma / Q000378:metabolism*; D012552:Schistosomiasis / Q000097:blood / Q000469:parasitology; D012556:Schistosomicides / Q000097:blood
chemical_list: D006454:Hemoglobins; D012556:Schistosomicides; D009569:Nitric Oxide; D006433:Hemocyanins