Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature.
Primary gastric T-cell lymphoma (PGTL) not associated with human T-lymphotropic virus type I (HTLV-I) is extremely rare and such a case is reported herein. The patient was a 58-year-old Japanese male presenting with submucosal tumor of the stomach identified on endoscopic examination. The lesion was diagnosed as non-Hodgkin's lymphoma by endoscopic biopsy and classified as peripheral T-cell lymphoma, unspecified, due to clonal rearrangement of the T-cell receptor beta (TCR) gene and expression of TCR beta protein in the absence of B-cell genotypes and phenotypes. Unlike previously reported cases of HTLV-I-unassociated PGTL, lymphoma in the current case was characterized histologically as "low grade" and phenotypically as CD4+, TIA-1+, granzyme B+, and CD103-. The lymphoma responded well to chemotherapy and radiation, and the patient was well with no detectable disease 10 months after initiation of therapy. A review of patients with PGTL in the literature revealed a few long-term survivors, and the investigation of therapeutic strategies for PGTL is, therefore, necessary.
Niitsu
N
N
Department of Internal Medicine IV, Kitasato University School of Medicine, Kanagawa, Japan. nniitsu@med.kitasato-u.ac.jp
Nakamine
H
H
Kohri
M
M
Hayama
M
M
Tamaru
J
J
Iwabuchi
K
K
Tanabe
S
S
Horie
R
R
Higashihara
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D015139:Blotting, Southern; D001853:Bone Marrow / Q000473:pathology; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011878:Radiotherapy; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy
D016693:Receptors, Antigen, T-Cell, alpha-beta