title: Synthesis and hybridization property of novel 2',5'-isoDNA mimic chiral peptide nucleic acids.
abstract: 2',5'-isoDNA mimic chiral peptide nucleic acid (isoPNA) monomers derived from D- and L-aspartic acids were synthesized. These novel monomers were incorporated in aminoethylglycine peptide nucleic acid (aegPNA) thymine dodecamers, and the hybridization properties to RNA and DNA were demonstrated by UV thermal denaturation.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Aziz
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Masami
authors.initials: M
authors.lastname: Otsuka
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D004151:Dipeptides / Q000737:chemistry; D006358:Hot Temperature; D018716:Molecular Mimicry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000235:genetics; D011489:Protein Denaturation; D018075:RNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014466:Ultraviolet Rays
chemical_list: D018076:DNA, Complementary; D004151:Dipeptides; D020135:Peptide Nucleic Acids; D018075:RNA, Complementary; D001224:Aspartic Acid; C065992:N-glycylalanine