title: Spectrophotometric determination of binary mixtures of pseudoephedrine with some histamine H1-receptor antagonists using derivative ratio spectrum method.
abstract: A derivative spectrophotometric method is developed for the assay of three binary mixtures of pseudoephedrine with fexofenadine (mix I), cetirizine (mix II) and loratadine (mix III). The method is based on the use of the first derivative of the ratio spectrum. The ratio spectrum was obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other component was determined from its respective calibration graph treated similarly. Moreover, the influence of Deltalambda for obtaining the first derivative of the ratio spectra and the effect of the divisor concentration on the calibration graphs were studied. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
authors.affiliation: Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, EL-Messalah, Egypt. pharmacy_alex@hotmail.com
authors.forename: Hoda
authors.initials: H
authors.lastname: Mahgoub
authors.forename: Azza A
authors.initials: AA
authors.lastname: Gazy
authors.forename: Fawzi A
authors.initials: FA
authors.lastname: El-Yazbi
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: El-Sayed
authors.forename: Rasha M
authors.initials: RM
authors.lastname: Youssef
mesh_terms: D002626:Chemistry, Pharmaceutical; D004809:Ephedrine / Q000032:analysis*; D006634:Histamine H1 Antagonists / Q000032:analysis*; D019999:Pharmaceutical Solutions / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D006634:Histamine H1 Antagonists; D019999:Pharmaceutical Solutions; D004809:Ephedrine