title: Expressions of latent membrane protein 1, p53 and bcl-2 proteins and their significance in Hodgkin's lymphoma.
abstract: OBJECTIVE
  To study the expressions of latent membrane protein 1 (LMP1), p53 and bcl-2 proteins and investigate their significance in the pathogenesis of Hodgkin's lymphoma.
  
  
  METHODS
  Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin's lymphoma.
  
  
  RESULTS
  The positivity rates of LMP1, p53 and bcl-2 proteins were 58.1% (18/31), 61.3% (19/31) and 35.5% (11/31), respectively, showing a statistically significant difference between the expressions of the former 2 proteins.
  
  
  CONCLUSIONS
  p53 may be involved as an important agent in the pathogenesis of Hodgkin's lymphoma induced by LMP1, whereas bcl-2 appears unrelated to the development of this disease.
authors.affiliation: Department of Pathology, First Military Medical University, Guangzhou 510515, China. qizongli@sina.com
authors.forename: Zong-li
authors.initials: ZL
authors.lastname: Qi
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Zhou
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Zhang
authors.forename: Xi-qun
authors.initials: XQ
authors.lastname: Han
authors.forename: Mei-gang
authors.initials: MG
authors.lastname: Zhu
mesh_terms: D000328:Adult; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D014763:Viral Matrix Proteins / Q000096:biosynthesis*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D014763:Viral Matrix Proteins