title: Synthesis of functionalized piperidinones.
abstract: A versatile, stereoselective synthesis of 5-hydroxypiperidinones with substituents at N1, C3, and C6 has been developed. The sequence involves ring-closing metathesis of a diene amide and epoxidation of the resulting alkene, followed by base-mediated elimination, and finally hydrogenation.
authors.affiliation: Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Humphries
authors.forename: James
authors.initials: J
authors.lastname: Murphy
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Phillips
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Abell