title: Angiosarcoma masquerading as embryonal carcinoma in the metastasis from a mature testicular teratoma.
abstract: Sarcoma can arise within a germ cell tumor (GCT) from a malignant transformation of teratomatous elements or as late sequelae to radiation therapy. Angiosarcoma as a malignant component in testicular GCTs has rarely been reported and is often misdiagnosed as embryonal carcinoma. We report the case of a 23-year-old man with mature teratoma of the testis and retroperitoneal metastasis exhibiting components of mature teratoma intermingled with high-grade angiosarcoma. It is important to recognize the presence of a high-grade sarcomatous component within a GCT because of its aggressive clinical behavior and different response to therapy.
authors.affiliation: Department of Pathology, Section of Hematology and Oncology, The University of Chicago, Chicago, IL, USA. sunati@hotmail.com
authors.forename: Sunati
authors.initials: S
authors.lastname: Sahoo
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Ryan
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Recant
authors.forename: Ximing J
authors.initials: XJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D018236:Carcinoma, Embryonal / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D013724:Teratoma / Q000175:diagnosis* / Q000556:secondary*; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology*