Improvement in blood lipid levels by dietary sn-1,3-diacylglycerol in young women with variants of lipid transporters 54T-FABP2 and -493g-MTP.
In a double-blind parallel-group study, serum lipids and visceral fat/total fat ratio in young women (n=49) with variants of lipid transporters, i.e., fatty acid binding protein 2 (FABP2) and microsomal triglyceride transfer protein (MTP), were analyzed by substituting dietary triacylglycerol (TAG) with sn-1,3-diacylglycerol (DAG). All subjects, including some with the hyperlipidemia-prone genotypes Ala54Thr of FABP2 and c-493g of MTP, received DAG or TAG (20 g/day) for 8 weeks. Reductions of serum lipids from weeks 4 to 8 in FABP2-Ala54Thr heterozygotes and MTP -493g homozygotes were significantly different between the DAG and TAG groups (p<0.05, p<0.01). Visceral fat/total fat (%), as determined by computed tomography (CT), was lower in FABP2-Ala54Thr heterozygotes (p<0.05) of the DAG group. The apoCII/CIII ratio was higher in the DAG group than in the TAG group (p<0.01). Other variants of lipid metabolism, including peroxisome proliferator activated receptors (PPARs) alpha and gamma and SREBP cleavage-activating protein (SCAP), were only slightly affected by dietary DAG.


CONCLUSIONS
improvement of serum lipid profiles and visceral fat/total fat ratio (CT) was potentiated by DAG intake in subjects with hyperlipidemia-prone genotypes (Ala54Thr heterozygotes of FABP2 and -493g homozygotes of MTP).
Yanagisawa
Yoshiko
Y
Department of Medical Chemistry, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan. yyanagi@eiyo.ac.jp
Kawabata
Terue
T
Tanaka
Osamu
O
Kawakami
Masanobu
M
Hasegawa
Kyoko
K
Kagawa
Yasuo
Y
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004041:Dietary Fats; D004075:Diglycerides / Q000008:administration & dosage*; D004311:Double-Blind Method; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood*; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; D004041:Dietary Fats; D004075:Diglycerides; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D008055:Lipids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; C106092:microsomal triglyceride transfer protein