Hepatosplenic alpha beta T-cell lymphoma: a report of an S100-positive case.
Hepatosplenic T-cell lymphoma is an uncommon neoplasm characterized by a lymphoid infiltrate within the sinusoids of the liver, spleen, and bone marrow, without significant nodal involvement. The majority of cases express the gammadelta T-cell receptor and are associated with an isochromosome 7q cytogenetic abnormality. Recently, a small number of cases have been reported that express the alphabeta T-cell receptor. Here, we report our findings of a case of an S100-positive hepatosplenic alphabeta T-cell lymphoma in a 20-year-old woman who presented with pancytopenia and hepatosplenomegaly. The case adds to the growing literature of hepatosplenic alphabeta T-cell lymphomas.
Dong
Jingyu
J
Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Chong
Yap-Yee
YY
Meyerson
Howard J
HJ
D000328:Adult; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000235:genetics*; D009418:S100 Proteins / Q000096:biosynthesis* / Q000235:genetics; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000235:genetics*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D009418:S100 Proteins