title: Florfenicol resistance in Salmonella enterica serovar Newport mediated by a plasmid related to R55 from Klebsiella pneumoniae.
abstract: Florfenicol resistance has emerged over the past few years in multidrug-resistant Salmonella enterica serovars Typhimurium, Agona and Paratyphi B. The floR gene encoding florfenicol resistance is chromosomally located in these serovars within a genomic island of 43 kb called SGI1 (Salmonella genomic island 1). In the present study, we characterized florfenicol resistance in a strain of S. enterica serovar Newport isolated from a turkey in 1990 and that lacked SGI1. Florfenicol resistance was mediated by a conjugative plasmid related to R55 from Klebsiella pneumoniae, which was characterized initially in the 1970s and harbours a gene 95% identical to floR.
authors.affiliation: Unité de Pathologie Aviaire et Parasitologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
authors.forename: Danièle
authors.initials: D
authors.lastname: Meunier
authors.forename: Sylvie
authors.initials: S
authors.lastname: Baucheron
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Chaslus-Dancla
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Martel
authors.forename: Axel
authors.initials: A
authors.lastname: Cloeckaert
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015139:Blotting, Southern; D024901:Drug Resistance, Multiple, Bacterial; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics*; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014422:Turkeys / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol