title: Localization of angiotensin II (AT1)-receptor-immunoreactive fibres in the hypothalamus of rats: angiotensin II-sensitive tanycytes in the ependyma of the third ventricle?
abstract: Scanning the hypothalamus of rats for receptor binding sites of the octapeptide hormone angiotensin II (ANG II), we observed ANG II-sensitive fibres in the ventrolateral hypothalamus. The ANG II (AT(1))-receptor-immunoreactive processes originate from cells-probably tanycytes-embedded in the base and the ventrolateral walls of the third ventricle and reach into the retrochiasmatic area, the ventrolateral hypothalamus and the median eminence.
authors.affiliation: Institute of Pharmacology and Toxicology, Ruprecht-Karls University of Heidelberg, Germany. mthomas@stud.uni-frankfurt.de
authors.forename: Martin Alexander
authors.initials: MA
authors.lastname: Thomas
authors.forename: Stefan
authors.initials: S
authors.lastname: Hauptfleisch
authors.forename: Gerta
authors.initials: G
authors.lastname: Fleissner
authors.forename: Björn
authors.initials: B
authors.lastname: Lemmer
mesh_terms: D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D004805:Ependyma / Q000737:chemistry*; D007031:Hypothalamus / Q000737:chemistry*; D007120:Immunochemistry; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000032:analysis*; D020542:Third Ventricle / Q000737:chemistry*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D000804:Angiotensin II