title: Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors.
abstract: The structure-activity relationship of a novel series of substituted piperazinone-based factor Xa inhibitors is described. The most potent compound 34 displays IC(50) of 0.9 nM.
authors.affiliation: Department of Medicinal Chemistry, Millennium Pharmaceuticals Inc., 256 East Grand Avenue, South San Francisco, CA 94080, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Su
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Deborah
authors.initials: D
authors.lastname: Volkots
authors.forename: John
authors.initials: J
authors.lastname: Woolfrey
authors.forename: Suiko
authors.initials: S
authors.lastname: Dam
authors.forename: Paul
authors.initials: P
authors.lastname: Wong
authors.forename: Uma
authors.initials: U
authors.lastname: Sinha
authors.forename: Robert M
authors.initials: RM
authors.lastname: Scarborough
authors.forename: Bing-Yan
authors.initials: BY
authors.lastname: Zhu
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis / Q000737:chemistry; D001665:Binding Sites; D015195:Drug Design; D065427:Factor Xa Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D010879:Piperazines; D015842:Serine Proteinase Inhibitors; D013917:Thrombin