Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam.
OBJECTIVE
Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration > or = 1 g/l) was tested (n = 127) in a controlled randomized open-label study.


RESULTS
Efficacy and safety were not different between groups (total group: delirium, 3.9%; seizure, 0.8%), except for a lack of efficacy in 18% of intoxicated tiapride/carbamazepine patients. A change of medication in this group was necessary only when primarily intoxicated patients had reached the non-intoxicated range.


CONCLUSIONS
Treatment with tiapride/carbamazepine in alcohol-intoxicated patients proved to be safe.
Lucht
M
M
Department of Psychiatry and Psychotherapy, University of Greifswald and Hospital for Addictive Disorders, Stralsund General Hospital, Germany.
Kuehn
K U
KU
Armbruster
J
J
Abraham
G
G
Gaensicke
M
M
Barnow
S
S
Tretzel
H
H
Freyberger
H J
HJ
D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy*; D020270:Alcohol Withdrawal Seizures / Q000188:drug therapy*; D000435:Alcoholic Intoxication / Q000534:rehabilitation*; D000437:Alcoholism / Q000534:rehabilitation*; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002719:Chlormethiazole / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D013976:Tiapamil Hydrochloride / Q000627:therapeutic use*; D016896:Treatment Outcome
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002719:Chlormethiazole; D002220:Carbamazepine; D003975:Diazepam; D013976:Tiapamil Hydrochloride