Lipid peroxidation in chronic gastritis; any influence of Helicobacter pylori?
In an attempt to investigate the significance of lipid peroxidation in the pathogenesis of gastritis associated with or without Helicobacter pylori infection, malonodialdehyde (MDA) levels were measured by the thiobarbiturate assay in the gastric juice of 101 patients undergoing upper GI endoscopy and correlated with histopathological findings. Elevated MDA levels were found in all patients with gastritis compared with controls. MDA levels were significantly correlated with the extent of the mucosal inflammation and with disease activity in patients with reactive gastritis. In patients with H. pylori associated gastritis MDA levels were not correlated with disease activity but rather with the degree of atrophy. In this case, MDA levels were equal or even less than in patients with reactive gastritis. MDA levels were not affected by the history of consumption of PPIs, of H(2)-blockers or of NSAIDs over the last month before the endoscopy. It is concluded that lipid peroxidation is a mechanism involved in the pathogenesis of gastritis associated or not to H. pylori infection.
Giamarellos-Bourboulis
Evangelos J
EJ
4th Department of Internal Medicine, Sismanoglion General Hospital, 1 Sismanogliou Street, Maroussi Attikis 151 26, Greece. giamarel@internet.gr
Tzivras
Michalis
M
Kourtesas
Dimitrios
D
Arnaoutis
Theodora P
TP
Delladatsima
Ioanna
I
Dionyssiou-Asteriou
Amalia
A
Davaris
Panayiotis
P
Vafiadis-Zouboulis
Irene
I
Archimandritis
Athanasios
A
D000368:Aged; D002908:Chronic Disease; D005260:Female; D005609:Free Radicals; D005750:Gastric Juice / Q000382:microbiology; D005756:Gastritis / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism / Q000494:pharmacology; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D015999:Multivariate Analysis; D009504:Neutrophils / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances
D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde