Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.
Seo
Eun-Kyoung
EK
Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA.
Lee
Dongho
D
Shin
Young Geun
YG
Chai
Hee-Byung
HB
Navarro
Hernán A
HA
Kardono
Leonardus B S
LB
Rahman
Ismail
I
Cordell
Geoffrey A
GA
Farnsworth
Norman R
NR
Pezzuto
John M
JM
Kinghorn
A Douglas
AD
Wani
Mansukh C
MC
Wall
Monroe E
ME
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D005419:Flavonoids; D010936:Plant Extracts; C477220:artobiloxanthone; C066727:artonin E