title: The complex nature of protein phosphatases.
abstract: Protein phosphatases are integrally associated with the regulation of cellular signaling. The mechanisms underlying the specific regulatory roles are likely to be unique to each cell system. Nevertheless, analysis of phosphatase regulation in a number of systems has identified phosphatase targeting through association with a wide range of binding partners to be a fundamental mechanism of regulation. Using protein phosphatase 2A (PP2A) as an example, this snapshot summarizes these fundamental mechanisms of protein phosphatase regulation.
authors.affiliation: School of Biomedical Sciences. Faculty of Health Sciences, The University of Newcastle, NSW 2308, Australia. Alistair.sim@newcastle.edu.au
authors.forename: Alistair T R
authors.initials: AT
authors.lastname: Sim
authors.forename: Russell I
authors.initials: RI
authors.lastname: Ludowyke
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D054648:Protein Phosphatase 2; D020836:Protein Structure, Quaternary; D015398:Signal Transduction
chemical_list: D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2