Feasibility of radioactive embolization of intracranial aneurysms using 32P-implanted coils.
OBJECTIVE
Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of 32P per centimeter.


METHODS
We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 microCi/cm of 32P, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of 32P in cystic craniopharyngiomas.


RESULTS
Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment.


CONCLUSIONS
Radioactive coil embolization of aneurysms is feasible in most patients.
Raymond
Jean
J
Department of Radiology, Research Centre of Centre Hospitalier de l'Université de Montréal, Québec, Canada. dr_jean_raymond@hotmail.com
Leblanc
Philippe
P
Lambert
Anick
A
Georganos
Stavros A
SA
Guilbert
François
F
Janicki
Christian
C
Roorda
Sjoerd
S
D000328:Adult; D000368:Aged; D001610:Beta Particles; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010761:Phosphorus Radioisotopes; D019736:Prostheses and Implants; D012189:Retrospective Studies
D010761:Phosphorus Radioisotopes