title: Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy.
abstract: The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20-24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.
authors.affiliation: Institut für Organische Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. ltietze@gwdg.de
authors.forename: Lutz F
authors.initials: LF
authors.lastname: Tietze
authors.forename: Ulrich
authors.initials: U
authors.lastname: Griesbach
authors.forename: Ingrid
authors.initials: I
authors.lastname: Schuberth
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bothe
authors.forename: Alberto
authors.initials: A
authors.lastname: Marra
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dondoni
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016754:Boron Neutron Capture Therapy; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides