Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis.
OBJECTIVE
To observe the preventive effects of combined therapy of AMD (allantoin, metronidazolem and dexamethasone in combination) on intra-abdominal adhesion in dogs.


METHODS
20 dogs of both sexes were used in this study. After laparotomy under anesthesia, 2 cm section of cecal end was clamped and ligated, then 1 cm cecum section was cut and another 1 cm was kept. The cecum stump was closed with purse-string suture. Both parietal and visceral peritonea were stripped for an area of about 3X4 cm(2). Before the skin closure, the animals were divided into two groups randomly. The abdominal cavities in Group AMD (n=10) were rinsed by 200 ml of AMD solution, and with 50 ml left, whereas the control (n=10) received the equal volume of normal saline. After 7 d, the degree of intra-abdominal adhesions was evaluated by using the score method of ultrasonography and traditional dissection.


RESULTS
Compared with the control, both the ultrasonography and traditional dissection scores in Group AMD were significantly decreased that marked as 2.0+/-1.25 vs 3.3+/-0.82 and 1.91+/-0.83 vs 3.3+/-0.82 respectively (P<0.01).


CONCLUSIONS
The combined therapy of AMD is an effective way to prevent intra-abdominal adhesion, and ultrasonography is an useful tool to diagnose intra-abdominal adhesion.
Wang
Xiao-Chen
XC
Anhui Provincial Center for Drug Clinical Evaluation and Yijishan Hospital of Wanan Medical Collage, 93 TuanJieDong Lu, Wuhu 241001, Anhui Province, China.
Gui
Chang-Qing
CQ
Zheng
Qing-Shan
QS
D000005:Abdomen / Q000473:pathology*; D000481:Allantoin / Q000627:therapeutic use*; D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000517:prevention & control
D005938:Glucocorticoids; D008795:Metronidazole; D000481:Allantoin; D003907:Dexamethasone