Monoclonal anti-idiotypic antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicits antigen-specific humoral and cellular immune responses in colorectal cancer patients.
Monoclonal rat anti-idiotypic antibody (Ab2) BR3E4 mimicking the colorectal carcinoma (CRC)-associated epitope CO17-1A induced antigen-specific humoral and cellular immune responses in mice and rabbits. Ab2 BR3E4 was administered in a phase I trial to CRC patients either as intact IgG or as F(ab')(2) coupled to keyhole limpet hemocyanin (KLH). There was a trend for the F(ab')(2)-KLH-immunized patients to show higher immune response rates (18/21 and 5/15 patients with anti-anti-idiotypic antibodies and T cells, respectively) than the IgG-immunized patients (15/23 and 3/15 patients positive). Clinical responses were rare in these patients with liver metastases.
Birebent
Brigitte
B
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Mitchell
Edith
E
Akis
Nese
N
Li
Weiping
W
Somasundaram
Rajasekharan
R
Purev
Enkhtsetseg
E
Hoey
Diane
D
Mastrangelo
Michael
M
Maguire
Henry
H
Harris
David T
DT
Nair
Sridhar
S
Cai
Dewei
D
Zhang
Tianqian
T
Herlyn
Dorothee M
DM
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000627:therapeutic use; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000276:immunology*; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G; C050928:carcinoma-associated antigen 17-1A; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin