title: Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population.
abstract: Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young ( approximately 14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and -521 C/T, there was no direct correlation with the personality traits.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Anam Hospital, 126-1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea. kuhj@netsgo.com
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Hong-Seock
authors.initials: HS
authors.lastname: Lee
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
authors.forename: Kwang-Yoon
authors.initials: KY
authors.lastname: Suh
authors.forename: Sangduk
authors.initials: S
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000483:Alleles; D000704:Analysis of Variance; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D007723:Korea; D018598:Minisatellite Repeats / Q000235:genetics; D010551:Personality / Q000235:genetics*; D010552:Personality Assessment; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
chemical_list: C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D004247:DNA