Molecular approaches to spinal cord repair.
Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.
David
Samuel
S
Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4. sdavid11@po-box.mcgill.ca
Lacroix
Steve
S
D000818:Animals; D001369:Axons / Q000502:physiology; D002921:Cicatrix / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008967:Molecular Biology; D009185:Myelin Proteins / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009433:Neural Inhibition; D000070798:Nogo Proteins; D015398:Signal Transduction / Q000502:physiology; D013119:Spinal Cord Injuries / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D000070798:Nogo Proteins; C000603199:RTN4 protein, human