title: Forced oscillation technique in the sleep apnoea/hypopnoea syndrome: identification of respiratory events and nasal continuous positive airway pressure titration.
abstract: Sleep breathing disorders (SBD) are related to obstructions resulting from repetitive narrowing and closure of the pharyngeal airway. Their diagnoses and treatment are critically dependent on an accurate identification of and discrimination between types of respiratory events. However, these disorders have been diagnosed using indirect or invasive measurements, which resulted in serious doubts concerning the correct evaluation of breathing events. The forced oscillation technique (FOT) has recently been suggested as a clinical tool able to accurately and non-invasively quantify respiratory obstruction during sleep. The present study investigates the morphology of the impedance signal during different sleep respiratory events and evaluates the ability of impedance measurements in providing adequate nasal continuous positive airway pressure (nCPAP) titration. The results evidenced characteristic patterns in impedance signal morphology that are useful in the identification and classification of abnormal respiratory events. Moreover, significantly higher impedance values were obtained during apnoea and hypopnoea events when compared with normal values (p < 0.01). Studies using impedance measurements to adjust nCPAP showed a significant reduction (p < 0.01) of abnormal respiratory events, and a consequent normalization of the patients. These findings support the use of the FOT as a versatile clinic diagnostic tool helping SBD diagnosis and treatment.
authors.affiliation: Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, and Microcirculation Research Laboratory, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Lucas N A
authors.initials: LN
authors.lastname: Lemes
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Melo
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D015992:Body Mass Index; D003937:Diagnosis, Differential; D004867:Equipment Design; D006801:Humans; D009991:Oscillometry; D010614:Pharynx / Q000503:physiopathology; D011175:Positive-Pressure Respiration / Q000295:instrumentation; D012016:Reference Values; D015656:Respiratory Mechanics; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D020919:Sleep Disorders, Intrinsic / Q000175:diagnosis* / Q000503:physiopathology