Release of pentoxifylline from xanthan gum matrix tablets.
Pentoxifylline-controlled release tablets were prepared using xanthan gum. The effects of polymer concentration, rotation speed, ionic strength, and pH of the dissolution medium on the release of the water-soluble pentoxifylline were studied. The release rate decreased with increasing polymer concentration in the tablet, which was reflected in the increase in the mean dissolution time. A higher rotation speed and increased ionic strength of the dissolution medium resulted in a higher rate of drug release of xanthan-based tablets. A higher release rate of pentoxifylline was also observed using acidic dissolution medium.
El-Gazayerly
Omaima N
ON
Pharmaceutics Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. gazayerly@hotmail.com
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D010431:Pentoxifylline / Q000008:administration & dosage / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013997:Time Factors; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D010975:Platelet Aggregation Inhibitors; D011108:Polymers; D011135:Polysaccharides, Bacterial; D013607:Tablets; D014867:Water; D012965:Sodium Chloride; D010431:Pentoxifylline; C002563:xanthan gum