title: [A new model of choroidal neovascularization in mice].
abstract: OBJECTIVE
  To investigate the feasibility of inducing choroidal neovascularization (CNV) in mice by diode laser.
  
  
  METHODS
  Two hours, 3 days, 1 week, 2 weeks and 4 weeks after photocoagulation, the effect of diode laser for inducing CNV by fundus fluorescein angiography (FFA), light microscopy and transmission electron microscopy.
  
  
  RESULTS
  Two hours and 3 days after laser treatment, there were no CNV and fluorescent leakage observed in mice. The first signs of leakage in FFA associated with CNV appeared 1 week after the postphotocoagulation, (48/90 lesions, or 53.3%). Four weeks after laser treatment, there were still 33 lesions appearing leakage (36.67%). Histological sections proved the existence of CNV, but the rate of CNV was not in accord with that of fluorescence leakage.
  
  
  CONCLUSIONS
  This animal model is very useful for in vivo studies of angiogenesis and its modulation via various therapy.
authors.affiliation: Ophthalmic Center, the Affiliated Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. lanbowang1972@yahoo.com
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Kangsun
authors.initials: K
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Rongjia
authors.initials: R
authors.lastname: Chen
authors.forename: Haiyun
authors.initials: H
authors.lastname: Shi
mesh_terms: D000818:Animals; D020256:Choroidal Neovascularization / Q000473:pathology*; D004195:Disease Models, Animal; D007834:Lasers / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic