Theoretical study concerning the reactivity of imine derivatives of polycyclic aromatic hydrocarbons.
The opening reaction of N-protonated polycyclic aromatic hydrocarbon imines has been computed by means of ab initio, density functional, and semiempirical methods of calculation. Imines are predicted to be more stable than the corresponding O-protonated derivatives, epoxides and diol epoxides. On the other hand, the activated N-methanesulfonylbenzene imine presented more favorable DeltaE( not equal ) and DeltaE(r) for ring opening due to the effect of hydrogen-bond interactions. Anti and syn trans-diol benzene imines did not show a different behavior from the unsubstituted imine. According to these calculations, bay-region, fjord-region, and bay-region methyl-substituted compounds opened more easily among the imine derivatives, following the same reactivity pattern as the oxygen analogs. The exothermicity of the opening process correlated with the charge delocalization in the resulting carbocation.
Borosky
Gabriela L
GL
Unidad de Matemática y Física, INFIQC, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina. gborosky@fcq.unc.edu.ar
D002273:Carcinogens / Q000737:chemistry*; D003500:Cyclization; D004852:Epoxy Compounds / Q000737:chemistry; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D008968:Molecular Conformation; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry*; D014961:X-Ray Diffraction
D002273:Carcinogens; D004852:Epoxy Compounds; D007097:Imines; D011084:Polycyclic Aromatic Hydrocarbons; D009584:Nitrogen