Bone marrow histopathologic and molecular staging in epidermotropic T-cell lymphomas.
This study was undertaken to determine the prognostic value of bone marrow histopathologic and molecular analyses in 53 patients with mycosis fungoides and 7 with Sézary syndrome. Bone marrow was involved in only 1 patient with Sézary syndrome, clinical stage IVA, before bone marrow biopsy. An ambiguous T-cell infiltrate was observed in 8 patients but was not associated with disease progression. The bone marrow specimen was normal in 51 patients. Monoclonality was detected in the skin specimen in 44 cases; an identical T-cell clone in the blood specimen was found in 21 of them and, in 16 of the 21 patients, in bone marrow specimens without histologic correlation. Multivariate analysis confirmed that clinical stage and detection by polymerase chain reaction of an identical T-cell clone in skin and blood specimens had an independent prognostic value. No further prognostic value was observed for the presence of a T-cell clone in bone marrow specimens. Our data do not support the need for bone marrow examination in patients with mycosis fungoides/Sézary syndrome.
Sibaud
Vincent
V
Oncodermatology Unit, Dermatology Department, Saint-André University Hospital of Bordeaux, Bordeaux, France.
Beylot-Barry
Marie
M
Thiébaut
Rodolphe
R
Parrens
Marie
M
Vergier
Béatrice
B
Delaunay
Michèle
M
Beylot
Claire
C
Chêne
Geneviève
G
Ferrer
Jacky
J
de Mascarel
Antoine
A
Dubus
Pierre
P
Merlio
Jean Philippe
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology*; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D011446:Prospective Studies; D012751:Sezary Syndrome / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm