title: Effects of hydration on blood rheology.
abstract: This study investigated the impact of oral fluid intake on blood rheology of 17 healthy adults following a 12-14 hour overnight fast from food and drink. An oral fluid load of 500 ml was consumed every 30 minutes for 2 hours. Blood viscosity values at shear rates of 1, 10 and 100 s(-1) were reduced (p<0.05 to p<0.01) at 30 and 120 minutes following hydration; however, these differences were not significant after hematocrit correction. With fluid intake, both uncorrected and corrected viscous component of blood viscoelasticity at oscillatory shear rate of 1 s(-1) and at a constant frequency of 2 Hz were reduced (p<0.05 to p<0.001) at all time points as compared to fasting values. The corrected elastic component of blood viscoelasticity increased 90 minutes after hydration (p<0.05). An overnight fast is accompanied by rheological abnormalities that are altered by fluid intake.
authors.affiliation: Lipoprotein and Hemorheology Research Facility, Department of Medicine and Pathology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA. vlastos@northwestern.edu
authors.forename: George A
authors.initials: GA
authors.lastname: Vlastos
authors.forename: Christine C
authors.initials: CC
authors.lastname: Tangney
authors.forename: Robert S
authors.initials: RS
authors.lastname: Rosenson
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D001809:Blood Viscosity / Q000502:physiology*; D004326:Drinking / Q000502:physiology*; D004548:Elasticity; D005215:Fasting; D005260:Female; D005440:Fluid Therapy; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013997:Time Factors