Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.
Permar
Sallie R
SR
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Klumpp
Sherry A
SA
Mansfield
Keith G
KG
Kim
Woong-Ki
WK
Gorgone
Darci A
DA
Lifton
Michelle A
MA
Williams
Kenneth C
KC
Schmitz
Jörn E
JE
Reimann
Keith A
KA
Axthelm
Michael K
MK
Polack
Fernando P
FP
Griffin
Diane E
DE
Letvin
Norman L
NL
D000818:Animals; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007111:Immunity, Cellular; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D008457:Measles / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication / Q000276:immunology
D004279:DNA, Viral; D008458:Measles Vaccine; D012367:RNA, Viral