title: Modification of urinary secretion of 8-hydroxy-2'-deoxyguanosine and serum ACTH concentration following repetitive parabolic flights.
abstract: It is important to clarify the molecular mechanisms of physiological responses of the human body to changes in gravity. Previous reports demonstrated that gravity-changing stress increases the human urinary concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG). However, it has yet to be clarified whether repetitive parabolic flight modulates the urinary concentration of 8-OHdG after exposure to gravity-changing stress. In the present study, the effects of the number of previous experiences with parabolic flight on urinary excretion of 8-OHdG and concentration of serum ACTH were examined in 12 healthy volunteers.
authors.affiliation: Department of Environmental Biochemistry, Chiba University, Chiba, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Arase
authors.forename: S
authors.initials: S
authors.lastname: Sugaya
authors.forename: T
authors.initials: T
authors.lastname: Moriya
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Kita
authors.forename: K
authors.initials: K
authors.lastname: Kikuno
authors.forename: F
authors.initials: F
authors.lastname: Nomura
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000222:Adaptation, Physiological / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000328:Adult; D003404:Creatinine / Q000378:metabolism / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D013026:Space Flight; D014893:Weightlessness
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000324:Adrenocorticotropic Hormone; D003404:Creatinine; D003849:Deoxyguanosine