Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures.
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.
Yuhas
Yael
Y
Felsenstein Medical Research Cente, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel.
Weizman
Abraham
A
Ashkenazi
Shai
S
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004405:Dysentery, Bacillary / Q000150:complications*; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D012640:Seizures / Q000209:etiology* / Q000517:prevention & control*; D012762:Shigella dysenteriae / Q000472:pathogenicity*; D013010:Sonication; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology* / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha; D010433:Pentylenetetrazole