Apoptosis during lymphoid development.
Recent investigations have provided important insights into how signaling through the antigen receptors determines whether a cell survives or dies. In T cells, Grb2 and MAP kinases play essential roles in differentiating between apoptotic and survival signals. The PTEN phosphatase and Bim, a pro-apoptotic Bcl-2 family member, regulate apoptosis in both T and B cells. In B cells, antigen receptor-mediated death can be rescued by co-stimulation, in which the roles of protein kinase C and BAFF, a TNF family member, have been recently elucidated. In a recently identified mechanism of regulating inflammation, receptors such as c-mer and glycoproteins such as MFG-E8 were found to participate in the clearance of apoptotic cells.
Sohn
Sue J
SJ
Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory 469, Life Science Addition, University of California, Berkeley, CA 94720-3200, USA.
Rajpal
Arvind
A
Winoto
Astar
A
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell