Molecular genetics of renal development.
The understanding of the complex branching morphogenesis of the early kidney is at an early stage; however, a framework is emerging that suggests numerous active genes sequentially switching on and reciprocally influencing each other. Much of our understanding of this process comes from studies of rodents specifically engineered to lack a particular gene responsible for an inductive agent or receptor. This review attempts to place newly discovered genetic programs within an organized framework of sequential renal development.
Levin
Michael E
ME
Pediatric Urology, Mount Sinai School of Medicine, 5 E. 98th Street, Box 1272, New York, NY 10029, USA.
Schlussel
Richard N
RN
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000196:embryology*; D008565:Membrane Proteins / Q000502:physiology; D008967:Molecular Biology; D020890:Neuregulin-1 / Q000502:physiology; D051762:PAX2 Transcription Factor; D011506:Proteins / Q000502:physiology; D050396:TRPP Cation Channels; D014157:Transcription Factors / Q000502:physiology; D014513:Ureter / Q000196:embryology
D000804:Angiotensin II; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D020890:Neuregulin-1; D051762:PAX2 Transcription Factor; D011506:Proteins; D050396:TRPP Cation Channels; D014157:Transcription Factors; C497318:PAX2 protein, human