The Southeast Collaboratory for Structural Genomics: a high-throughput gene to structure factory.
The Southeast Collaboratory for Structural Genomics consists of four working groups. The protein production group supplies/develops high-output production of Pyrococcus furiosus, Caenorhabditis elegans, and selected human proteins. The X-ray crystallography group conducts high-throughput structure production in parallel with production-related research/development in nanocrystallization robotics, capillary crystallization cassette, synchrotron/home X-ray instrumentation, sample mounting robotics, data processing and pipelined structure analysis, combined refinement/validation protocols, and direct use of unlabeled native crystals (Direct Crystallography). The NMR group emphasizes/develops sample screening and backbone structure determination from residual dipolar coupling data. The bioinformatics group implements/develops local database interfaces, pipelined sequence/structure information search/updates, and database/bioinformatics toolkits.
Adams
Michael W W
MW
Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA.
Dailey
Harry A
HA
DeLucas
Lawrence J
LJ
Luo
Ming
M
Prestegard
James H
JH
Rose
John P
JP
Wang
Bi-Cheng
BC
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry* / Q000235:genetics; D003299:Cooperative Behavior; D003460:Crystallization; D018360:Crystallography, X-Ray; D001330:Electronic Data Processing; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D020027:Pyrococcus furiosus / Q000235:genetics*; D011994:Recombinant Proteins / Q000737:chemistry* / Q000235:genetics; D012371:Robotics; D015144:Southeastern United States; D014495:Universities
D029742:Caenorhabditis elegans Proteins; D011994:Recombinant Proteins