Human Herpesvirus 8: Biology and Role in the Pathogenesis of Kaposi's Sarcoma and Other AIDS-related Malignancies.
Human herpesvirus type 8, or Kaposi's sarcoma-associated herpesvirus (KSHV), is the only known human g(2) herpesvirus (rhadinovirus) and the most recently discovered tumor virus. KSHV is associated with Kaposi's sarcoma and two other lymphoproliferative disorders in the AIDS setting: primary effusion lymphoma and the plasma cell variant of multicentric Castleman's disease. This review offers an update on the epidemiology and the role of KSHV genes in the development of disease.
Viejo-Borbolla
Abel
A
*Department of Virology, Hannover Medical School, Carl-Neuberg-Str.1, D-30625 Hannover, Germany. tschulz@virologie.mh-hannover.de
Ottinger
Matthias
M
Schulz
Thomas F.
TF