Bioactive constituents of Leptadenia arborea.
The aerial part of Leptadenia arborea has been shown to contain pinoresinol (1), syringaresinol (2), leucanthemitol (3) and E-ferulaldehyde (4). These known compounds are being reported for the first time from this plant. Among them, syringaresinol has shown an inhibitory effect against acetylcholinesterase. The IC(50) (the concentration of 50% enzyme inhibition) value of this compound was 200 microg/ml.
El-Hassan
A
A
Aswan-Faculty of Science, South Valley University, Aswan, Egypt.
El-Sayed
M
M
Hamed
A I
AI
Rhee
I K
IK
Ahmed
A A
AA
Zeller
K P
KP
Verpoorte
R
R
D000110:Acetylcholinesterase; D029062:Apocynaceae; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D002800:Cholinesterase Inhibitors; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; C042192:syringaresinol; D000110:Acetylcholinesterase