Expressions of latent membrane protein 1, p53 and bcl-2 proteins and their significance in Hodgkin's lymphoma.
OBJECTIVE
To study the expressions of latent membrane protein 1 (LMP1), p53 and bcl-2 proteins and investigate their significance in the pathogenesis of Hodgkin's lymphoma.


METHODS
Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin's lymphoma.


RESULTS
The positivity rates of LMP1, p53 and bcl-2 proteins were 58.1% (18/31), 61.3% (19/31) and 35.5% (11/31), respectively, showing a statistically significant difference between the expressions of the former 2 proteins.


CONCLUSIONS
p53 may be involved as an important agent in the pathogenesis of Hodgkin's lymphoma induced by LMP1, whereas bcl-2 appears unrelated to the development of this disease.
Qi
Zong-li
ZL
Department of Pathology, First Military Medical University, Guangzhou 510515, China. qizongli@sina.com
Zhao
Tong
T
Zhou
Xin-hua
XH
Zhang
Jin-hua
JH
Han
Xi-qun
XQ
Zhu
Mei-gang
MG
D000328:Adult; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D014763:Viral Matrix Proteins / Q000096:biosynthesis*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D014763:Viral Matrix Proteins