title: Reduced-intensity stem cell transplantation in children and adolescents: the Mexican experience.
abstract: A group of 21 consecutive patients aged 4-20 (median 13) years was prospectively allografted using a reduced intensity preparative regimen. The group included both malignant (acute lymphoblastic leukemia, acute myelogenous leukemia, and chronic myelogenous leukemia) and nonmalignant (aplastic anemia, Diamond-Blackfan anemia, thalassemia major and adrenoleukodystrophy) conditions. Follow-up times ranged between 16 and 1038 days. Four of 21 patients (9.5%) developed acute graft-versus-host disease, and 2 of them died, whereas limited chronic graft-versus-host disease was observed in 2 of 15 cases. The 100-day mortality was 19%. Median overall survival was above 1038 days, whereas the 34-month survival was 55%. These data show that reduced intensity stem cell transplantation in children permits rapid engraftment from siblings with little toxicity.
authors.affiliation: Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Almaguer
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.forename: Luz del Carmen
authors.initials: Ldel C
authors.lastname: Tarín-Arzaga
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Llano
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Jaime-Pérez
authors.forename: Briceida
authors.initials: B
authors.lastname: López-Martínez
authors.forename: Olga G
authors.initials: OG
authors.lastname: Cantú-Rodríguez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Herrera-Garza
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease; D006402:Hematologic Diseases / Q000150:complications / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D008297:Male; D008800:Mexico; D016019:Survival Analysis; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous