Axonal transport of membranous and nonmembranous cargoes: a unified perspective.
Membranous and nonmembranous cargoes are transported along axons in the fast and slow components of axonal transport, respectively. Recent observations on the movement of cytoskeletal polymers in axons suggest that slow axonal transport is generated by fast motors and that the slow rate is due to rapid movements interrupted by prolonged pauses. This supports a unified perspective for fast and slow axonal transport based on rapid movements of diverse cargo structures that differ in the proportion of the time that they spend moving. A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1) accompanies this Mini-Review.
Brown
Anthony
A
The Ohio State University, Neurobiotechnology Center, Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA. brown.2302@osu.edu
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D020409:Molecular Motor Proteins / Q000502:physiology; D009420:Nervous System / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D011108:Polymers / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology
D046911:Macromolecular Substances; D020409:Molecular Motor Proteins; D011108:Polymers