Mechanisms involved in platelet hyperactivation and platelet-endothelium interrelationships in diabetes mellitus.
This article discusses the recent findings about the mechanisms involved in platelet hyperactivation in diabetes mellitus. Particular attention is focused on the advances pertaining to 1) new features of platelet activation; 2) the role of calcium fluxes; 3) the role of glucose, insulin, and insulin resistance; 4) the role of nitric oxide; and 5) the role of endothelium.
Trovati
Mariella
M
Diabetes Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano 10043, Turin, Italy. mariella.trovati@unito.it
Anfossi
Giovanni
G
D001792:Blood Platelets / Q000502:physiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D009569:Nitric Oxide / Q000378:metabolism; D015539:Platelet Activation
D007328:Insulin; D009569:Nitric Oxide