title: CD36 deficiency and absent myocardial iodine-123-(R,S)-15-(p-iodophenyl)-3-methylpentadecanoic acid uptake in a girl with cardiomyopathy.
abstract: A 10-year-old girl presented left ventricular failure 1 month after the onset of hemolytic uremic syndrome (HUS) caused by an Escherichia coli O157 infection and was diagnosed as having dilated cardiomyopathy. Thallium myocardial scintigraphy showed normal perfusion, but no myocardial uptake of iodine-123-( R, S)-15-( p-iodophenyl)-3-methylpentadecanoic acid ((123)I-BMIPP) was observed. We analyzed the CD36 expression in platelets and monocytes by using a flowcytometer, and she turned out to have CD36 deficiency type I.
  
  
  CONCLUSIONS
  Some patients may be predisposed to myocardial damage in the presence of CD36 deficiency. It is necessary to clarify the etiological significance of the relationship between cardiac impairment and CD36 deficiency in children.
authors.affiliation: Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, Moriguchi, 570-8506, Osaka, Japan. teraguch@takii.kmu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Teraguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohkohchi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ikemoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Higashino
authors.forename: Yohnosuke
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D018955:CD36 Antigens / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000378:metabolism*; D002648:Child; D004927:Escherichia coli Infections / Q000150:complications; D019453:Escherichia coli O157; D005227:Fatty Acids; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
chemical_list: D018955:CD36 Antigens; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C049338:iodofiltic acid