title: Fibrin glue as a sealant for high-risk anastomosis in surgery for morbid obesity.
abstract: BACKGROUND
  Fibrin sealants promote hemostasis and wound healing. Complex revisional surgery is performed for morbid obesity, and high-risk patients undergo weight loss surgery routinely. Fibrin sealant, Tisseel, was used by one surgeon on 120 consecutive patients at the gastrojejunal anastomosis in Roux-en-Y gastric bypass (RYGBP). We hypothesized that the application of fibrin sealant would decrease anastomotic leaks.
  
  
  METHODS
  One surgeon (Surgeon A) used fibrin sealant for 120 consecutive patients, while two other surgeons (Surgeons B & C) served as controls and did not use fibrin glue for their last 120 patients. Surgeon A did not use fibrin glue in 120 patients to serve as an internal control. All 480 patients underwent a RYGBP. Fibrin glue was applied at the gastrojejunal anastomosis.
  
  
  RESULTS
  The fibrin sealant group did not have any documented leaks on the previous 120 patients, while 5 patients with Surgeon B, 2 patients with Surgeon C and 1 patient with Surgeon A without fibrin sealant experienced enteric leaks requiring re-operation, drainage, or long-term total parenteral nutrition (N = 480 total patients).
  
  
  CONCLUSIONS
  Fibrin sealant may be useful in preventing leaks and promoting healing of the "high risk" anastomosis during complex gastrointestinal surgery. While the cost of fibrin glue is to be considered, re-operation and management of subsequent enterocutanous fistulas or anastomotic strictures may be more costly than routine use for high-risk morbidly obese patients.
authors.affiliation: University of California, Los Angeles School of Medicine and Greater Los Angeles VA Medical Center, Department of Surgery, Los Angeles, CA 10833, USA. cdliu@mednet.ucla.edu
authors.forename: Carson D
authors.initials: CD
authors.lastname: Liu
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Glantz
authors.forename: Edward H
authors.initials: EH
authors.lastname: Livingston
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery; D012086:Reoperation; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives