Synthesis and hybridization property of novel 2',5'-isoDNA mimic chiral peptide nucleic acids.
2',5'-isoDNA mimic chiral peptide nucleic acid (isoPNA) monomers derived from D- and L-aspartic acids were synthesized. These novel monomers were incorporated in aminoethylglycine peptide nucleic acid (aegPNA) thymine dodecamers, and the hybridization properties to RNA and DNA were demonstrated by UV thermal denaturation.
Abdel-Aziz
Mohamed
M
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan.
Yamasaki
Tetsuo
T
Otsuka
Masami
M
D001224:Aspartic Acid / Q000737:chemistry; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D004151:Dipeptides / Q000737:chemistry; D006358:Hot Temperature; D018716:Molecular Mimicry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000235:genetics; D011489:Protein Denaturation; D018075:RNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014466:Ultraviolet Rays
D018076:DNA, Complementary; D004151:Dipeptides; D020135:Peptide Nucleic Acids; D018075:RNA, Complementary; D001224:Aspartic Acid; C065992:N-glycylalanine