Fort Chaffee revisited: the epidemiology of tick-borne rickettsial and ehrlichial diseases at a natural focus.
A retrospective cohort study was conducted among troops training at Fort Chaffee, Arkansas, from May through June 1997, to identify infections caused by tick-borne pathogens. Serum samples were tested by IFAs for antibodies to selected Rickettsia and Ehrlichia species and by an investigational EIA for spotted fever group Rickettsia lipopolysaccharide antigens. Of 1,067 guardsmen tested, 162 (15.2%) had antibodies to one or more pathogens. Of 93 guardsmen with paired serum samples, 33 seroconverted to Rickettsia rickettsii or spotted fever group rickettsiae (SFGR) and five to Ehrlichia species. Most (84.8%) of the personnel who seroconverted to SFGR were detected only by EIA, and seropositivity was significantly associated with an illness compatible with a tick-borne disease. In addition, 34 (27%) of 126 subjects with detectable antibody titers reported a compatible illness. The primary risk factor for confirmed or probable disease was finding > 10 ticks on the body. Doxycycline use and rolling up of long sleeves were protective against seropositivity. The risk of transmission of tick-borne pathogens at Fort Chaffee remains high, and use of the broadly reactive EIA suggests that previous investigations may have underestimated the risk for infection by SFGR. Measures to prevent tick bite and associated disease may require reevaluation.
McCall
C L
CL
Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. cmccall@cdc.gov
Curns
A T
AT
Rotz
L D
LD
Singleton
J A
JA
Treadwell
T A
TA
Comer
J A
JA
Nicholson
W L
WL
Olson
J G
JG
Childs
J E
JE
D000293:Adolescent; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000032:analysis; D001096:Arachnid Vectors / Q000382:microbiology; D001131:Arkansas / Q000453:epidemiology; D003020:Clothing; D015331:Cohort Studies; D004318:Doxycycline / Q000627:therapeutic use; D004536:Ehrlichia / Q000276:immunology / Q000302:isolation & purification; D016873:Ehrlichiosis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008887:Military Medicine; D008889:Military Personnel; D012281:Rickettsia / Q000276:immunology / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D012307:Risk Factors; D013983:Tick Control; D017282:Tick-Borne Diseases / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D013987:Ticks / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004318:Doxycycline