title: Limitations of randomized clinical trials in chronic diseases: explanations and recommendations.
authors.affiliation: Division of Rheumatology and Immunology at Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Theodore
authors.initials: T
authors.lastname: Pincus
mesh_terms: D002908:Chronic Disease; D002985:Clinical Protocols; D003625:Data Collection / Q000379:methods / Q000592:standards; D003627:Data Interpretation, Statistical; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards*; D012107:Research Design / Q000592:standards