title: [Oligoastrocytoma with signet-ring cell differentiation. A morphological, ultrastructural and immunohistochemical study].
abstract: We present a case of a mixed glial tumor (oligoastrocytoma) with signet-ring cells. This cellular feature is a rare differentiation in glial tumors of the central nervous system. Histological, immunohistochemical and ultrastructural findings have been analyzed. Signet-ring cells showed intense expression with GFAP, S-100 and vimentin. A differential diagnosis with other primary brain tumors and cerebral metástases with signet-ring cell differentiation was discussed.
authors.affiliation: Hospital Clínico Universitario. Facultad de Medicina. Universidad de Valencia. Valencia. Spain.
authors.forename: D
authors.initials: D
authors.lastname: Ramos
authors.forename: M
authors.initials: M
authors.lastname: Cerdá-Nicolás
authors.forename: C
authors.initials: C
authors.lastname: López-Ginés
authors.forename: P
authors.initials: P
authors.lastname: Roldán
authors.forename: J
authors.initials: J
authors.lastname: Molla
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Bacete
authors.forename: F
authors.initials: F
authors.lastname: Talamantes
authors.forename: J
authors.initials: J
authors.lastname: Barberá
authors.forename: A
authors.initials: A
authors.lastname: Llombart-Bosch
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000473:pathology* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry