Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum.
Triethanolamine is an ethanolamine used as counter-ion for fatty acid soaps. Interaction between triethanolamine and free fatty acids is suggested to be useful for cleansing sebaceous follicles in acne prevention. This study describes the preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with stearic acid--a compound of artificial skin sebum. Penetration of triethanolamine into artificial sebum, induced by the above mentioned interaction, was measured using a specific optical method. The values of the penetration depth amounted to 0.07-5.74 mm. pH values were measured. The value of pH is reduced from 10.06 for pure 1.49% (w/w) aqueous triethanolamine solution to 6.61 with the increase of the alginic acid to triethanolamine ratio in the preparations. The data of this in vitro research will support further study on other anionic polymers as factors buffering ethanolamines penetrating artificial skin sebum.
Musiał
Witold
W
Department of Pharmaceutical Technology, Faculty of Pharmacy, The Silesian Piasts Memorial Medical University of Wroclaw, Wroclaw, Poland. witold@bf.uni.wroc.pl
Kubis
Aleksander
A
D000464:Alginates / Q000737:chemistry*; D002021:Buffers; D004339:Drug Compounding; D004983:Ethanolamines / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010539:Permeability; D012629:Sebum / Q000737:chemistry*; D017768:Skin, Artificial; D013997:Time Factors
D000464:Alginates; D002021:Buffers; D004983:Ethanolamines; D006603:Hexuronic Acids; D020723:Glucuronic Acid; C009546:triethanolamine