Neuroepithelial tumor of the retina in a dog.
METHODS
At routine vaccination a tumor in the right eye of a Golden Retriever was diagnosed.


METHODS
The eye was enucleated, fixed in formalin and processed according to routine paraffin technique. Standard histologic, histochemical and immunohistochemical stainings were applied. Formalin-fixed tissue was used for electron microscopic examination.


RESULTS
The tumor originated from the retina and was composed of two different morphologic parts, a retinoblastoma-like part of small neuroepithelial cells and a medulloepithelioma-like part of columnar cells arranged in cords.


CONCLUSIONS
It is discussed whether the tumor had its origin in different clones or in one clone, and it is suggested that the double differentiation might be the result of a transformation of retinal cells, demasking stem cell-like potentials.
Jensen
Ove A
OA
Eye Pathology Institute, Fr V's Vej 11, University of Copenhagen, 2100 Copenhagen Ø, Denmark, Dyrehospitalet, Ringe, Denmark. oaj@eyepath.ku.dk
Kaarsholm
Susanne
S
Prause
Jan U
JU
Heegaard
Steffen
S
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*