Recent progress in the development of coumarin derivatives as potent anti-HIV agents.
Numerous plant-derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives. A dicamphanoyl-khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively.
Yu
Donglei
D
Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Suzuki
Madoka
M
Xie
Lan
L
Morris-Natschke
Susan L
SL
Lee
Kuo-Hsiung
KH
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006678:HIV / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D012995:Solubility; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D003374:Coumarins; C030123:coumarin