title: A convenient stereoselective synthesis of trifluoromethyl-substituted polyfunctionalized cyclopropane: synthesis of (+/-)-trans-trifluoronorcoronamic acid.
abstract: Trifluoromethylated polyfunctionalized cyclopropanes were obtained in high stereoselectivity by reacting 2-bromo-3,3,3-trifluoropropene (BrTFP) with active methylenes. This novel method was further applied to the synthesis of (+/-)-trans-trifluoronorcoronamic acid.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PR China. jiangb@pub.sioc.ac.cn
authors.forename: Biao
authors.initials: B
authors.lastname: Jiang
authors.forename: Fangjiang
authors.initials: F
authors.lastname: Zhang
authors.forename: Wennan
authors.initials: W
authors.lastname: Xiong
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D005617:Chlorofluorocarbons, Methane; D003521:Cyclopropanes; C043950:1-amino-2-ethylcyclopropane-1-carboxylic acid; C009554:fluoroform