title: Physical stability and enthalpy relaxation of drug-hydroxypropyl methylcellulose phthalate solvent change co-precipitates.
abstract: The poorly water-soluble drug GWX was co-precipitated with hydroxypropyl methylcellulose phthalate (HPMCP) using a solvent change method. The two co-precipitate formulations made, with drug-HPMCP ratios of 2:8 and 5:5, were analysed using modulated temperature differential scanning calorimetry. They were found to consist of completely amorphous solid solution and a mixture of amorphous solid solution, crystalline drug and amorphous drug, respectively. Stability with respect to crystallization of the two co-precipitates and pure amorphous drug made by quench cooling was compared by storing preparations at 25 degrees C and 40 degrees C, under vacuum over P(2)O(5), and at 75% relative humidity (r.h.). Humidity (75% r.h. compared with dry) had a larger influence on crystallization of the amorphous drug than temperature (25 degrees C compared with 40 degrees C). The solid solution phase in co-precipitates had a relatively higher stability than amorphous drug alone, with respect to crystallization, in presence of the plasticizer water, and crystalline drug. These findings were partly explained by evidence of decreased molecular mobility in the amorphous solid solution with respect to amorphous drug alone, using enthalpy relaxation measurements. At an ageing temperature of 65 degrees C, the calculated half-life for enthalpy relaxation of the 2:8 drug-HPMCP ratio coprecipitate was about 6 orders of magnitude greater than that of amorphous drug alone, indicating a large difference in relative molecular mobility.
authors.affiliation: School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand. gabriel.sertsou@stonebow.otago.ac.nz
authors.forename: Gabriel
authors.initials: G
authors.lastname: Sertsou
authors.forename: James
authors.initials: J
authors.lastname: Butler
authors.forename: John
authors.initials: J
authors.lastname: Hempenstall
authors.forename: Thomas
authors.initials: T
authors.lastname: Rades
mesh_terms: D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002627:Chemistry, Physical; D004337:Drug Carriers; D004347:Drug Interactions; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D004364:Pharmaceutical Preparations; D010968:Plasticizers / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D013696:Temperature
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D010968:Plasticizers; D012997:Solvents; D008747:Methylcellulose; C053309:hydroxypropyl methylcellulose phthalate