[Analysis of characteristics of gene expression in pericancerous stromal cells of nasopharyngeal carcinoma by cDNA array].
OBJECTIVE
The mechanism of how stromal cell play an important role in nasopharyngeal carcinogenesis is now a hotspot. This study was designed to elucidate the possible mechanism of stromal cell in the occurrence and progression of nasopharyngeal carcinoma (NPC) through the analysis of the characteristics of gene expression in pericancerous stromal cells of NPC by cDNA array.


METHODS
The atlas human select tumor arrays were used to compare the expression profiles between NPC tissue and NPC cell lines.


RESULTS
Pericancerous stromal cells in NPC expressed at least 40 genes specifically.


CONCLUSIONS
The specific expression of these genes in pericancerous stromal cells provides energy materials for growth of NPC cells; furthermore, it can accelerate the degradation of extracellular matrix, thus promoting the metastasis of NPC cells.
Li
Hong
H
Laboratory of Molecular Pathology, Cancer Research Institute, Xiangya Medical College, Central Southern University, Changsha, Hunan, 410078, P.R.China.
Han
Wei-Nong
WN
Feng
Xiang-Ling
XL
Zhou
Wen
W
Yao
Kai-Tai
KT
D018076:DNA, Complementary / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D015870:Gene Expression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D017154:Stromal Cells / Q000502:physiology*
D018076:DNA, Complementary; D004273:DNA, Neoplasm