title: H. influenzae Consortium: integrative study of H. influenzae-human interactions.
abstract: Developments in high-throughput analysis tools coupled with integrative computational techniques have enabled biological studies to reach new levels. The ability to correlate large volumes of diverse data types into cohesive models of organism function has spawned a new systematic approach to biological investigation. The creation of a new consortium has been proposed to investigate a single organism utilizing these comprehensive approaches. The Haemophilus influenzae Consortium (HIC) would be comprised of five laboratories, each providing separate and complementary areas of expertise in the study of Haemophilus influenzae (HI). The 5-year study proposes to develop coherent models of HI, both as a stand-alone organism, and more importantly, as a human pathogen. Studies in growth condition specificity followed by genomic, metabolic, and proteomic experimentation will be combined and integrated through computational and experimental analyses to form dynamic and predictive models of HI and its responses. Data from the HIC will allow greater understanding of cellular behavior, pathogen-host interactions, bacterial infection, and provide future scientific endeavors with a template for studies of other pathogens.
authors.affiliation: BIATECH, 19310 North Creek Parkway, Suite 115, Bothell, WA 98011, USA. ekolker@biatech.org
authors.forename: Eugene
authors.initials: E
authors.lastname: Kolker
authors.forename: Samuel
authors.initials: S
authors.lastname: Purvine
authors.forename: Alex
authors.initials: A
authors.lastname: Picone
authors.forename: Tim
authors.initials: T
authors.lastname: Cherny
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Akerley
authors.forename: Robert S
authors.initials: RS
authors.lastname: Munson
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Palsson
authors.forename: Dayle A
authors.initials: DA
authors.lastname: Daines
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Smith
mesh_terms: D001422:Bacterial Adhesion; D001424:Bacterial Infections; D018407:Bacterial Physiological Phenomena; D016680:Genome, Bacterial; D006193:Haemophilus influenzae / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012106:Research / Q000458:organization & administration*; D012984:Software