title: A role of the Duffy antigen for the maintenance of plasma chemokine concentrations.
abstract: We examined plasma chemokine concentrations and chemokine clearance rates in Duffy antigen knockout mice. The plasma concentrations of eotaxin and MCP-1 in Duffy antigen knockout mice were less than one-third of those in wild-type mice. When eotaxin or hMGSA was intravenously injected, the chemokine disappeared more rapidly from the plasma of Duffy antigen knockout mice than from the plasma of wild-type mice. The half-lives of hIP-10 and interferon-gamma, which do not have an affinity for the Duffy antigen, in plasma were indistinguishable between Duffy antigen knockout mice and wild-type mice. These results suggest that the Duffy antigen delays the disappearance of chemokines from the plasma, resulting in the maintenance of plasma chemokine concentrations.
authors.affiliation: Laboratory of Developmental Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3-1, 7-Chome, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Fukuma
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Akimitsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kusuhara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology*; D054413:Chemokine CCL11; D054360:Chemokine CXCL1; D054357:Chemokine CXCL10; D018925:Chemokines / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D019742:Chemokines, CC / Q000097:blood; D019743:Chemokines, CXC / Q000378:metabolism; D002630:Chemotactic Factors / Q000493:pharmacokinetics; D004375:Duffy Blood-Group System / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000493:pharmacokinetics; D007371:Interferon-gamma / Q000493:pharmacokinetics; D051379:Mice; D018345:Mice, Knockout; D015800:Protozoan Proteins / Q000378:metabolism* / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology*; D013997:Time Factors
chemical_list: D000953:Antigens, Protozoan; D002352:Carrier Proteins; C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D054360:Chemokine CXCL1; D054357:Chemokine CXCL10; D018925:Chemokines; D019742:Chemokines, CC; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C475895:Cxcl1 protein, mouse; D004375:Duffy Blood-Group System; C066001:Duffy antigen binding protein, Plasmodium; D036341:Intercellular Signaling Peptides and Proteins; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; D007371:Interferon-gamma