[S100 protein as tumoral marker in melanoma patients. Comparative study with sentinel node biopsy and whole body FDG-PET].
OBJECTIVE
Analyze the significance of serum S100 as tumor marker and study it in the sentinel node biopsy and in the whole body FDG-PET studies.


METHODS
332 melanoma patients diagnosed of cutaneous melanoma were included (41 untreated and 291 previously treated). Serum levels were measured by an immunoradiometric assay. Cut-off value was 0.2 microg/l.


RESULTS
In the 41 untreated patients, the S100 mean values were: mean 0.36 microg/l, median 0.29 microg/l, with 56.1% of positivities. Serum mean values in stage III and IV were significantly higher than stage I and II (0.489 microg/l vs 0.209 microg/l) (p < 0.05). The mean serum value of S100 in treated patients and without evidence of disease was 0.14 microg/l and the median 0.13 microg/l. Sensitivity and specificity for detection of recurrence or metastases in the follow-up were 76.2% and 88.6%, respectively. There is a correlation of 91.3% between S100 and FDG-PET studies (23 patients). S100 does not provide information on the sentinel lymph node biopsy.


CONCLUSIONS
S100 is not useful to diagnose melanoma in its early stages but it is a good tumor marker for the follow-up and monitoring of melanoma patients.
Ortiz
B
B
Sección de Marcadores Tumorales, Servicio de Laboratorio, Instituto Valenciano de Oncología, Valencia.
Vázquez
C
C
Martínez
C
C
Giménez
J
J
Sanmartín
O
O
de los Dolores
V
V
Ortega
F
F
Maíquez
J
J
Fliquete
M V
MV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood*; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology*; D014055:Tomography, Emission-Computed
D014408:Biomarkers, Tumor; D009418:S100 Proteins; D019788:Fluorodeoxyglucose F18