[Exposure level of total N-nitroso compounds in residents of high-and low-risk areas for esophageal cancer in southern].
OBJECTIVE
To assess the exposure level of total N-nitroso compounds (TNOCs) in the residents of high- and low-risk areas for esophageal cancer in southern China.


METHODS
Samples of duplicate plate diets and 12 hr overnight urine were collected from 120 male adults in each of the 2 areas, a high-risk area (Nanao county) and a low-risk area (Lufeng county) for esophageal cancer. The 240 male healthy subjects (35 - 64 years old) were selected by a 3-stage random cluster sampling procedure. Levels of TNOC, N-nitrosamino acids (NAAs) and volatile N-nitroso compounds (VNOC) in the samples were measured by Thermo Energy Analyzer.


RESULTS
The detectable rate (95%) of diet TNOC, daily dietary TNOC intake (4.25 +/- 0.84) micromol/day, 12-hr urinary TNOC excretion levels (1.76 +/- 0.23 ng/12 h) and daily dietary intake of VNOC (266 +/- 31.2 microg/day) in the high-risk area were all significantly higher than those of the low-risk area. Oesophageal cancer mortality rates were positively and significantly associated with daily dietary TNOC intake and 12-hr urinary TNOC excretion. Urinary NAAs excretion levels were not different in the two areas.


CONCLUSIONS
The results suggest that TNOCs may be implicated in the etiology of esophageal cancer in southern China.
Lin
Kun
K
Shantou University Medical College, Shantou 515031, China.
Shen
Wenying
W
Wu
Yongning
Y
Lu
Shixin
S
D000328:Adult; D002681:China; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009603:Nitroso Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine
D009603:Nitroso Compounds