Depression and HIV infection: impact on immune function and disease progression.
Can psychological factors, such as depression, affect human immunodeficiency virus progression? HIV infection is viewed as a chronic illness in which those infected often confront a number of emotional challenges and physical health and disease-related issues. Over the past 20 years, there has been increasing evidence that depression and other mood-related disturbances are commonly observed among HIV-positive individuals. There is also mounting data showing that depressive symptoms might further impact upon specific elements of immune system functioning and influence quality of life and health status. This paper will highlight studies examining the prevalence of depression during HIV infection and review some of the evidence examining the impact of depressive symptoms on immune function and HIV disease progression.
Cruess
Dean G
DG
Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA. dcruess@psych.upenn.edu
Petitto
John M
JM
Leserman
Jane
J
Douglas
Steven D
SD
Gettes
David R
DR
Ten Have
Thomas R
TR
Evans
Dwight L
DL
D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D003866:Depressive Disorder / Q000276:immunology* / Q000523:psychology; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology / Q000523:psychology*; D006801:Humans; D011598:Psychoneuroimmunology; D012307:Risk Factors; D012803:Sick Role