The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
The newly synthesized linoleic acid derivative, FR236924, induces a long-lasting facilitation of hippocampal neurotransmission based on a persistent enhancement in the activity of presynaptic nicotinic ACh receptors via a PKC pathway and the ensuing increase in glutamate release, not only in vitro but in vivo at a low dosage (2mg/kg, ip), which suggested the possibility of its use as a promising anti-dementia drug.
Tanaka
Akito
A
Molecular Science, Exploratory Res. Lab., Fujisawa Pharmaceutical Co. Ltd., 5-2-3 Tokodai, Tsukuba, Japan. tanaka-a@reprori.jp
Nishizaki
Tomoyuki
T
D000473:Alkanes / Q000494:pharmacology*; D000818:Animals; D003521:Cyclopropanes / Q000494:pharmacology*; D015195:Drug Design; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008958:Models, Molecular; D018722:Nicotinic Agonists / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011978:Receptors, Nicotinic / Q000096:biosynthesis / Q000187:drug effects*; D017661:Receptors, Presynaptic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D014981:Xenopus
D000473:Alkanes; D003521:Cyclopropanes; C477949:FR236924; D005230:Fatty Acids, Nonesterified; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D017661:Receptors, Presynaptic; D018698:Glutamic Acid; D011493:Protein Kinase C