[A novel whole blood aggregometer].
We examined ADP-induced platelet aggregability in 45 patients by novel whole blood aggregometer based on the screen filtration pressure method. Platelet aggregation could be easily and immediately checked without preparing platelet rich plasma. This aggregometer was useful for determination of anesthetic methods for a patient with an anti-platelet therapy. However, PATI (platelet aggregately threshold index) demonstrated the lowest value 5 minutes after blood collection and the valve was stabilized at higher level for 30 to 120 minutes. Time-dependent change should be considered for assessment of platelet aggregability in a clinical study.
Konishi
Ruriko
R
Department of Anesthesiology, Jichi Medical School, Tochigi 329-0498.
Seo
Norimasa
N
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000758:Anesthesia / Q000379:methods; D005374:Filtration; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors; D010979:Platelet Function Tests / Q000295:instrumentation* / Q000379:methods; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate