Nucleoporin p62 antibodies in a case of mixed connective tissue disease.
Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders.
Kraemer
Doris M
DM
Medizinische Poliklinik, University of Wurzburg, 97070 Wurzburg, Germany. d.kraemer@medizin.uni-wuerzburg.de
Kraus
Michael R
MR
Kneitz
Christian
C
Tony
Hans-Peter
HP
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000276:immunology*; D028861:Nuclear Pore Complex Proteins; D011379:Prognosis
D001323:Autoantibodies; D008562:Membrane Glycoproteins; D028861:Nuclear Pore Complex Proteins; C049312:nuclear pore protein p62