Unilateral absence of the basal ganglia plus epilepsy without motor symptoms.
A patient with absence of the basal ganglia and refractory epilepsy without impairment of pyramidal or extrapyramidal motor function is reported. Imaging findings suggest a vascular insult as etiology. Preserved motor function could be explained by neuronal plasticity involving contralateral corticostriatal and pallidothalamic connections and points to a lesion received in early pregnancy.
Kellinghaus
C
C
Department of Neurology, The Cleveland Clinic Foundation, OH, USA. kellingc@ccf.org
Montgomery
E
E
Neme
S
S
Ruggieri
P
P
Lüders
H O
HO
D000293:Adolescent; D000328:Adult; D001479:Basal Ganglia / Q000002:abnormalities* / Q000473:pathology*; D002421:Caudate Nucleus / Q000002:abnormalities; D004828:Epilepsies, Partial / Q000209:etiology*; D005625:Frontal Lobe / Q000473:pathology; D005917:Globus Pallidus / Q000002:abnormalities; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011699:Putamen / Q000002:abnormalities; D013378:Substantia Nigra / Q000002:abnormalities; D020531:Subthalamic Nucleus / Q000002:abnormalities; D014055:Tomography, Emission-Computed