Are multiple CT scans required for planning curative radiotherapy in lung tumors of the lower lobe?
OBJECTIVE
Lung tumors located in the lower lobe are the most mobile. Multiple computed tomographic (CT) scans, which had been performed for radiotherapy planning, were analyzed to determine the minimal number of required scans.


METHODS
Six spiral CT scans (3 rapid and 3 slow) from 7 such patients were coregistered. Reproducibility of target volumes was defined as the ratio between the overlapping and encompassing volume (COM/SUM) from scans derived using one technique. Volumetric and dosimetric analyses were performed.


RESULTS
Slow CT scans generated larger and more reproducible target volumes than rapid planning scans, with a mean COM/SUM ratio of 71.9 +/- 8.7% and 58.0 +/- 12.7%, respectively. When only a single slow CT scan was used for planning, the addition of a symmetrical 3D margin of 5 mm ensured 99% coverage of the "optimal" target volume, which was derived from summation of target volumes from all six scans.


CONCLUSIONS
Planning target volumes (PTVs) derived from a single slow CT scan plus a 5-mm margin covered the "optimal" PTVs generated from six scans. Although these "slow PTVs" were larger, the increase in V(20) (the volume of lung tissue receiving a dose > or = 20 Gy) was limited. This indicates that only two CT scans, i.e., a full rapid scan of the entire thorax and a limited slow scan, are necessary for treatment planning in peripheral lung cancers.
de Koste
John R van Sörnsen
JR
Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.
Lagerwaard
Frank J
FJ
de Boer
Hans C J
HC
Nijssen-Visser
Margriet R J
MR
Senan
Suresh
S
D016477:Artifacts; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D009038:Motion; D009200:Myocardial Contraction; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012119:Respiration; D014057:Tomography, X-Ray Computed