title: [Age-related involution of organs and tissues].
abstract: Contemporary civilization confronts the humankind with the challenge of rapid ageing, which becomes especially relevant for developed countries. This necessitates the elaboration of optimal approaches to the management of ageing, which would enable a radical prolongation of active, full-value, working period of human life and, thus, would reduce the percentage of age-related disability. An essential role in the successful accomplishment of these objectives consists in the search for the mechanisms of age-related involution of organs and tissues. This overview presents and analysis of the modern concepts of these mechanisms.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch, Russian Academy of Medical Sciences.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoĭ
authors.forename: I E
authors.initials: IE
authors.lastname: Ingel'
authors.forename: A T
authors.initials: AT
authors.lastname: Mar'ianovich
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002490:Central Nervous System / Q000502:physiology; D005835:Genitalia / Q000502:physiology; D006801:Humans; D010870:Pineal Gland / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology