title: Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report.
abstract: The authors report on a case of spinal inflammatory myofibroblastic tumor (IMT) in a 22-year-oldwoman. Neuroradiological features of this intradural extramedullary mass were suggestive of a meningioma or neurinoma. The lesion was easily resected following a T-9 laminectomy. Light microscopy showed a proliferation of spindle cells with prominent nucleoli on a fibrous or edematous background with infiltration of numerous lymphocytes and plasma cells. Some spindle cells immunostained positively for ALK1. This led to the diagnosis of IMT. The patient's postoperative course was complicated by a multifocal local recurrence requiring a second surgery, which was followed by radio- and chemotherapy. The occurrence of IMT in the spinal cord has rarely been reported. In this case, ALK overexpression was associated with early multifocal recurrence. This has been recently reported in this tumor typein other locations.
authors.affiliation: Department of Pathology, CHU Rangueil, Toulouse, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Lacoste-Collin
authors.forename: Franck-Emmanuel
authors.initials: FE
authors.lastname: Roux
authors.forename: Anne
authors.initials: A
authors.lastname: Gomez-Brouchet
authors.forename: Marie-Line
authors.initials: ML
authors.lastname: Despeyroux
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uro-Coste
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009130:Muscle, Smooth / Q000473:pathology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases