title: Structural genomics of membrane proteins.
abstract: A program on the structural genomics of membrane proteins has started at the BIRC, AIST, involving other academic institutions and industrial companies. Emphasis is being put on the development of techniques for the structural determination of membrane proteins of biological importance and ligand-receptor interactions by means of electron microscopy, X-ray diffraction, NMR, and computer simulation. Most efforts at the present stage, however, are being directed to finding suitable expression and purification systems and crystallization conditions for such proteins. The program is expected to be linked with the human full-length cDNA project and should lead to medical and industrial uses.
authors.affiliation: Biological Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-41-6 Aomi, Koto-ku, Tokyo 135-0064, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kyogoku
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiyoshi
authors.forename: Ichio
authors.initials: I
authors.lastname: Shimada
authors.forename: Haruki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tomitake
authors.initials: T
authors.lastname: Tsukihara
authors.forename: Hideo
authors.initials: H
authors.lastname: Akutsu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Odahara
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Okada
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nomura
mesh_terms: D001436:Bacteriorhodopsins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D016045:Human Genome Project; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D008565:Membrane Proteins; D001436:Bacteriorhodopsins