Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction.
BACKGROUND
The purpose of this study was to examine the comparative effects of propofol and fentanyl on cerebral oxygenation during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction.


METHODS
One hundred eighty patients scheduled for elective coronary artery bypass grafting were randomly divided into two groups: propofol group (n = 90) and fentanyl group (n = 90). After induction of anesthesia, a fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to monitor jugular venous oxygen hemoglobin saturation continuously. Hemodynamic measurements and arterial and jugular venous blood gases were measured at seven time points. All patients underwent a battery of neurologic and neuropsychological tests on the day before the operation and at 6 months after the operation.


RESULTS
Cerebral desaturation (defined as a jugular venous oxygen hemoglobin saturation value less than 50%) during cardiopulmonary bypass was more frequent in the fentanyl group than in the propofol group. Cerebral desaturation time (duration when jugular venous oxygen hemoglobin saturation was less than 50%) and the ratio of cerebral desaturation time to total cardiopulmonary bypass time in the fentanyl group differed significantly from those in the propofol group (fentanyl group: 27 +/- 14 minutes, 20% +/- 9%; propofol group: 18 +/- 11 minutes, 14% +/- 7%, respectively, p < 0.05). There was no significant difference in postoperative cognitive dysfunction at 6 months after operation between the two groups (propofol group: 5 of 77, 6%; fentanyl group: 5 of 75, 7%).


CONCLUSIONS
Propofol preserved cerebral oxygenation state estimated by jugular venous oxygenation during cardiopulmonary bypass compared with the fentanyl group. However, propofol did not affect postoperative cognitive dysfunction.
Kadoi
Yuji
Y
Division of Intensive Care Medicine, Gunma University, School of Medicine, Maebashi, Gunma, Japan. kadoi@med.gunma-u.ac.jp
Saito
Shigeru
S
Kunimoto
Fumio
F
Goto
Fumio
F
Fujita
Nao
N
D000368:Aged; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply*; D002315:Cardiopulmonary Bypass; D003072:Cognition Disorders / Q000139:chemically induced* / Q000175:diagnosis; D001026:Coronary Artery Bypass; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010101:Oxygen Consumption / Q000187:drug effects*; D010108:Oxyhemoglobins / Q000378:metabolism; D011183:Postoperative Complications / Q000139:chemically induced* / Q000175:diagnosis; D015742:Propofol
D010108:Oxyhemoglobins; D005283:Fentanyl; D015742:Propofol