Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders.
OBJECTIVE
Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis.


METHODS
We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases.


RESULTS
The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p = 0.0014).


CONCLUSIONS
Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.
Obana
Nobuya
N
Department of Gastroenterology, Tohoku University Postgraduate School of Medicine, Sendai.
Takagi
Sho
S
Kinouchi
Yoshitaka
Y
Tokita
Yoshihisa
Y
Sekikawa
Akihiro
A
Takahashi
Seiichi
S
Hiwatashi
Nobuo
N
Oikawa
Shinichi
S
Shimosegawa
Tooru
T
D000368:Aged; D015139:Blotting, Southern; D016022:Case-Control Studies; D016922:Cellular Senescence / Q000502:physiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D012016:Reference Values; D012680:Sensitivity and Specificity; D016615:Telomere / Q000235:genetics / Q000648:ultrastructure*