title: Effect of iron deficiency anemia on renal tubular function in childhood.
abstract: Little is known about renal function in children with iron deficiency anemia. The purpose of this study was to investigate renal tubular function in these children. We compared renal tubular function in 20 children with iron deficiency anemia with 20 healthy age-matched controls. Blood and urine samples were obtained for hematological and biochemical analysis. Mean fractional excretion of sodium and mean urinary N-acetyl-beta- D-glucosaminidase/creatinine were significantly higher in the children with iron deficiency anemia than in controls (P<0.05). Hemoglobin levels were negatively correlated with urinary N-acetyl-beta- D-glucosaminidase/creatinine (r= -0.44, P=0.015), but were not correlated with fractional excretion of sodium (r= -0.29, P=0.13). There was no correlation between urinary N-acetyl-beta- D-glucosaminidase/creatinine and fractional excretion of sodium (r=0.32, P=0.09). The results suggest that children with iron deficiency anemia have impaired renal tubular function.
authors.affiliation: Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey. fozcay@superonline.com
authors.forename: Figen
authors.initials: F
authors.lastname: Ozçay
authors.forename: Murat
authors.initials: M
authors.lastname: Derbent
authors.forename: Derya
authors.initials: D
authors.lastname: Aldemir
authors.forename: Suna
authors.initials: S
authors.lastname: Türkoğlu
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
authors.forename: Umit
authors.initials: U
authors.lastname: Saatçi
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D018798:Anemia, Iron-Deficiency / Q000150:complications* / Q000503:physiopathology* / Q000652:urine; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D012964:Sodium / Q000652:urine
chemical_list: D012964:Sodium; D003404:Creatinine; D000118:Acetylglucosaminidase