Bioactive lipids and their receptors.
Recent studies show that several, if not all, degradative products of glycerol- and sphingosine-based lipids are active molecules that play important roles in different signal transduction pathways. The functions and actions of lysophosphatidic acid and sphingosine 1-phosphate, the degradation products of phospholipids and sphingolipids, respectively, have received a great deal of attention during the past few years. These lipid mediators are active through several abundant G protein-coupled receptors that were recently identified and characterized. This review will discuss recent achievements in the area of bioactive lipids.
Angel
Itzchak
I
D-Pharm Ltd, Kiryat Weizmann Science Park, PO Box 2313, Rehovot 76123, Israel. iangel@dpharm.com
Bar
Adina
A
Haring
Rachel
R
D000818:Animals; D006801:Humans; D008055:Lipids / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology; D011955:Receptors, Drug / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D013107:Sphingolipids / Q000494:pharmacology
D008055:Lipids; D011453:Prostaglandins; D011955:Receptors, Drug; D013107:Sphingolipids