title: [Toxicity and tetramine contents of salivary glands from carnivorous gastropods].
abstract: Salivary glands from 29 species of marine carnivorous gastropods in nine families were examined for lethal activity against mice and tetramine content. Mouse lethality was assayed by intravenous injection of buffer extracts into mice, and was detected in 14 species. Heat-stability tests confirmed that toxins in four species were thermolabile, while those in eight species were thermostable. Based on the tetramine contents determined by the colorimetric method using methanolic extracts, the thermostable toxins in seven species (Neptunea eulimatalamellosa, N. vinosa, N. arthritica, N. bulbacea, N. intersculpta f. pribiloffensis, N. intersculpta f. frater pilsbry and Hemifusus tuba) were considered to be tetramine contained at high levels (more than 900 micrograms/g salivary gland), but that in one species (Buccinum opisthoplectum) appeared to be a low-molecular-weight compound differing from tetramine. It is interesting that one (Hemifusus tuba) of the seven species containing high amounts of tetramine belongs to the family Melongenidae, although the other six Neptunea species are members of the family Buccinidae, as expected from previous studies.
authors.affiliation: Department of Food Science and Technology, Tokyo University of Fisheries: 4-5-7, Konan, Minato-ku, Tokyo 108-8477, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D000818:Animals; D001952:Bridged-Ring Compounds / Q000032:analysis*; D003124:Colorimetry; D008297:Male; D051379:Mice; D012469:Salivary Glands / Q000737:chemistry; D012758:Shellfish / Q000633:toxicity*
chemical_list: D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine