Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity.
A novel series of alpha-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.
Cooke
Andrew
A
Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Scotland, ML1 5SH, UK. a.cooke@organon.co.uk
Anderson
Alison
A
Bennett
Jonathan
J
Buchanan
Kirsteen
K
Gemmell
David
D
Hamilton
Niall
N
Maidment
Maurice
M
McPhail
Petula
P
Stevenson
Donald
D
Sundaram
Hardy
H
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004952:Esters; D058787:GABA-A Receptor Antagonists; D008297:Male; D051379:Mice; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects; D013329:Structure-Activity Relationship
D000596:Amino Acids; D018686:Anesthetics, Intravenous; D004952:Esters; D058787:GABA-A Receptor Antagonists; D010636:Phenols; D015742:Propofol