Endogenous gamma-hydroxybutyric acid is in the rat, mouse and human gastrointestinal tract.
By using Gas Chromatography-Mass Spectrometry high concentrations of endogenous gamma-hydroxybutyric acid (GHB) have been demonstrated in the rat and mouse gastrointestinal tract, including stomach, small intestine and colon-rectum. GHB concentrations were many folds higher than those present in the brain. High GHB concentrations have been also found in the human operatory specimen of sigmoid colon. Since GHB administration has been found to modify gastrointestinal motility via GABA(B) receptors, the present results suggest that endogenous GHB might be involved in the GABA(B) receptor-mediated control of gastrointestinal function.
Tedeschi
Luciano
L
Forensic Toxicology and Antidoping, University Hospital of Padova, Via Falloppio 50, I-35121, Padova, Italy.
Carai
Mauro A M
MA
Frison
Giampietro
G
Favretto
Donata
D
Colombo
Giancarlo
G
Ferrara
Santo Davide
SD
Gessa
Gian Luigi
GL
D020155:3-Hydroxybutyric Acid / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D012809:Colon, Sigmoid / Q000737:chemistry / Q000378:metabolism; D004064:Digestive System / Q000737:chemistry / Q000378:metabolism*; D005215:Fasting / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D051379:Mice; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar
D020155:3-Hydroxybutyric Acid