title: [Sphincter of Oddi dysfunction--prolonged medical therapy or early endoscopic sphincter ablation].
abstract: BACKGROUND
  Sphincter of Oddi dysfunction is a real challenge from both diagnostic and therapeutic point of view.
  
  
  METHODS
  In the last two years the authors have performed ERCP and EST in 29 patients with positive evocative test results, who had important enzyme elevations and/or did not respond to prolonged medical treatment.
  
  
  RESULTS
  Endoscopic findings were positive in 25/29 patients (86.2%): 8 adenoma of p. Vateri, 17 papillitis were identified, and in 4 cases the papilla was intact. Histopathology obtained in 12 patients supported the diagnosis. In 6 patients, who underwent a postpapillotomy evocative test, after an average of 10 months follow up the results have been converted from positive to negative response in all but two cases. The two patients continued to have abdominal symptoms with persistent positive provocation tests because of restenosis, were treated with repapillotomy.
  
  
  CONCLUSIONS
  The Debray and Nardi tests are useful screening tests for hypertonic biliary or pancreatic dyskinesia. Structural endoscopic and histological findings are frequent already in the functional cases. Early sphincter ablation should be considered in failure of medical therapy for preventing the transformation of this functional disorder into an organic, potentially precancerous state.
authors.affiliation: MAV Kórház, Gasztroenterológiai Osztály, Budapest.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Kovács
authors.forename: Tibor
authors.initials: T
authors.lastname: Gyökeres
authors.forename: Gábor
authors.initials: G
authors.lastname: Elek
authors.forename: Akos
authors.initials: A
authors.lastname: Pap
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D017115:Catheter Ablation; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000601:surgery; D020820:Dyskinesias / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009803:Sphincter of Oddi / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D017211:Treatment Failure; D016896:Treatment Outcome