Effects of hypokinesia on cyclic nucleotides and hormonal regulation of calcium metabolism in rats.
OBJECTIVE
To study the dynamic of changes in the level of parathyroid hormone (PTH), calcitonin (CT), cyclic nucleotides (cAMP, cGMP) and calcium in the blood of rats, while in urine--phosphate, calcium and cyclic nucleotides.


METHODS
Laboratory based experiment.


METHODS
Laboratory in the Department of Biochemistry, Faculty of Medicine, University of Nairobi, Nairobi, Kenya and in the Department of Biochemistry, Kharkov State University, Ukrain Republic.


RESULTS
Correlation between the changes in the parameters of study was shown. This supports the theory about the relationship between branches of hormonal systems (cyclic nucleotides-calcium), which perform the central role in the regulation of homeostasis. The results show that daily excretion of calcium and phosphate is age dependent in rats during the pathogenesis of hypokinesia: the values are higher in control groups. Changes in calcium in the blood and phosphaturia in the experimental animals of all ages were attributed to changes in the intensive re-absorption process within the bones during the readaptation period of hypokinesia.


CONCLUSIONS
Old rats have a higher ability to adaptation than younger experimental counterparts during hypokinesia.
Chek
J B L
JB
Department of Biochemistry, College of Biological and Physical Sciences, University of Nairobi, P.O. Box 30197, Nairobi, Kenya.
Laniko
A I
AI
D000375:Aging / Q000378:metabolism; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D018476:Hypokinesia / Q000378:metabolism*; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015290:Second Messenger Systems / Q000502:physiology; D013997:Time Factors
D010281:Parathyroid Hormone; D010710:Phosphates; D002116:Calcitonin; D003404:Creatinine; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium