title: Influence of cytokine and mannose binding protein gene polymorphisms on human T-cell leukemia virus type I (hTLV-I) provirus load in HTLV-I asymptomatic carriers.
abstract: Human T-cell leukemia virus type I (HTLV-I) provirus load differs more than 100-fold among carriers and a high provirus load in the peripheral blood mononuclear cells (PBMCs) is regarded as a risk factor for both preleukemic states and inflammatory diseases including HTLV-I-associated myelopathy (HAM). We examined polymorphisms in the genes for tumor necrosis factor (TNF), TNF receptor type 1 and 2, lymphotoxin (LT)-alpha, interleukin (IL)-1beta, IL-6, IL-10, monocyte chemoattractant protein (MCP)-1, and mannose binding protein (ManBP) in 143 HTLV-I carriers whether these polymorphisms affect the provirus load in the PBMCs of carriers. No significant association was observed between these polymorphisms and the provirus load. Homozygotes for a ManBP-variant allele, however, showed a tendency for the decreased number of provirus load. When combined, the data on the alleles of LT-alpha and MCP-1, HTLV-I carriers having high producer alleles of both genes showed a trend for increased provirus load. These data suggest that inflammation or an active immune response may induce an increased amount of HTLV-I-infected T cells, leading to a high provirus load.
authors.affiliation: Department of Clinical Neuroscience, Tokushima University School of Medicine, Tokushima, Japan. m_nishim@clin.med.tokshima-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishimura
authors.forename: Michiyuki
authors.initials: M
authors.lastname: Maeda
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Yasunaga
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Akio
authors.initials: A
authors.lastname: Adachi
authors.forename: Takashi
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
mesh_terms: D000483:Alleles; D044466:Asian People; D002353:Carrier State; D016207:Cytokines / Q000235:genetics*; D015329:Gene Rearrangement, T-Lymphocyte; D015490:HTLV-I Infections / Q000175:diagnosis; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D011110:Polymorphism, Genetic; D011533:Proviruses / Q000302:isolation & purification; D019562:Viral Load
chemical_list: D016207:Cytokines; D037601:Mannose-Binding Lectin