[Participation of a distant cholinergic mechanism in the response of the vascular bed to intoxication by organophosphorus inhibitors of cholinesterase].
Poisoning with phosphacol causes dose--dependent decrease of blood flow speed in small vessels of mesoappendix. Administration of LD50 of phosphacole results in blood stagnation, simultaneous blood pressure fall, which leads to death of part of the animals. Electron microscopic study revealed the presence of acetyl and buthyryl cholinesterase in endotheliocytes of mesoappendicular capillaries, the activity of which was completely suppressed by administration of LD50 of phosphacol. 0,0-dimethyl-0 (2,2-dichlorvinyl) phosphate LD10 caused the damage of endotheliocyte surface. It was suggested that endothelial cholino-receptors that are activated through the rise of redundant acetyl-choline level in blood on the background of cholinesterase inhibition participate in the mechanism of pathological reactions described. Such variant of toxic effect was characterized as distant.
Skopichev
V G
VG
Laboratory of Secretory Processes Physiology, A.A. Ukhtomscky Institute of Physiology, State University of St. Petersburg.
Prozorovskiĭ
V B
VB
Medvedeva
S V
SV
D000109:Acetylcholine / Q000502:physiology*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001065:Appendix / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure; D001783:Blood Flow Velocity / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000378:metabolism; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004006:Dichlorvos / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000648:ultrastructure; D007928:Lethal Dose 50; D010261:Paraoxon / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D004006:Dichlorvos; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D000109:Acetylcholine; D010261:Paraoxon