title: Familial non-rcd1 generalised retinal degeneration in Irish setters.
abstract: Four Irish setters were diagnosed with bilateral retinal degeneration and cataracts at an age ranging from six to 11 years. In three of these dogs, progressive night blindness was reported from an age of eight to 11 years. In the fourth dog, aged six, no signs of visual impairment had been noticed. In all four dogs, the rod-cone dysplasia type 1 (rcd1) mutation was excluded as a cause, using an allele-specific PCR. From their three-generation pedigrees, a familial relationship was detected in three out of four dogs, which were also related to four additional Irish setter dogs with a history and clinical signs suggestive of late-onset progressive retinal degeneration. These results suggest the existence of a possibly hereditary, late-onset, progressive retinal atrophy in the Irish setter breed, that is distinct from rcd1.
authors.affiliation: Department of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, PO Box 80154, 3508 TD Utrecht, The Netherlands.
authors.forename: S C
authors.initials: SC
authors.lastname: Djajadiningrat-Laanen
authors.forename: M H
authors.initials: MH
authors.lastname: Boevé
authors.forename: F C
authors.initials: FC
authors.lastname: Stades
authors.forename: B A
authors.initials: BA
authors.lastname: van Oost
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics; D000818:Animals; D017931:DNA Primers; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D009154:Mutation; D009426:Netherlands; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011996:Records / Q000662:veterinary; D015792:Retinal Dysplasia / Q000235:genetics / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D017931:DNA Primers; D015106:3',5'-Cyclic-GMP Phosphodiesterases