[Neutrophils in rheumatoid inflammation].
For many years a secondary role in the pathogenesis of rheumatoid arthritis has been ascribed to neutrophil, relatively to the inflammatory response's evaluation. This cell was considered lacking in a peculiar activity and ever depending on lymphocytes and monocytes. During the recent years the neutrophil has been recognized as a cytokines producing cell, really able to modulate its role in joints inflammation. In the light of the latest information it's possible reconsider the role of this cell, looking at it like a moderate co-protagonist in the expression of rheumatoid damage, regarding both to joint inflammation and the maintenance of the damage itself. On the grounds of these knowledge, polymorphonuclear granulocyte could be also chosen as target of the newest therapies in the treatment of this disease. The aim of this short review is to focus the activity of neutrophils in rheumatoid arthritis, trying to follow them through their migration from blood to sinovial tissue and to understand the dynamic relation with the cytokine network, that from these cells pathway depends.
Biasi
Domenico
D
Dipartimento di Medicina Clinica e Sperimentale, Università, Verona.
Carletto
Antonio
A
Caramaschi
Paola
P
Bonella
Francesco
F
Bambara
Valentina
V
Pacor
Maria Luisa
ML
Bambara
Lisa Maria
LM
D000936:Antigen-Antibody Complex / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D002449:Cell Aggregation; D002465:Cell Movement; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D016023:Integrins / Q000235:genetics / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010587:Phagocytosis; D012217:Rheumatoid Factor / Q000276:immunology / Q000502:physiology
D000936:Antigen-Antibody Complex; D016207:Cytokines; D016023:Integrins; D012217:Rheumatoid Factor