Viral coinfections among African children infected with human immunodeficiency virus type 1.
City-dwelling children from Kenya who were infected with human immunodeficiency virus type 1 (HIV-1) were tested for coinfection with cytomegalovirus (CMV), human T cell lymphotropic viruses 1 and 2, Kaposi sarcoma-associated herpesvirus (KSHV), or hepatitis B, C, and G viruses. All children were found to be coinfected with CMV, whereas 5% had hepatitis G virus coinfection and 15% had KSHV coinfection. A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children.
Chakraborty
Rana
R
Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. ranachakraborty@hotmail.com
Rees
Gareth
G
Bourboulia
Dimitra
D
Cross
Alexandra M
AM
Dixon
Jedediah R
JR
D'Agostino
Angelo
A
Musoke
Rachel
R
Boshoff
Chris
C
Rowland-Jones
Sarah L
SL
Klenerman
Paul
P
D000349:Africa / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications*; D018178:Flaviviridae Infections / Q000150:complications*; D029407:GB virus C; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D015497:HIV-1; D015490:HTLV-I Infections / Q000150:complications; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications; D019288:Herpesvirus 8, Human; D015368:Human T-lymphotropic virus 1; D015367:Human T-lymphotropic virus 2; D006801:Humans