Anti-inflammatory and antinociceptive activities of Loasa speciosa in rats and mice.
In the range of doses of 250-500 mg/kg (given i.p.) the aqueous extract of Loasa speciosa leaves showed an inhibitory effect on leukocyte migration, and a reduction on the pleural exudate, as well as dose-dependent anti-inflammatory and peripheral antinociceptive activities.
Badilla
B
B
Instituto de Investigación en Ciencias Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José 2060, Costa Rica. bbadilla@cariari.ucr.ac.cr
Arias
A Y
AY
Arias
M
M
Mora
G A
GA
Poveda
L J
LJ
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D029767:Cornaceae; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005557:Formaldehyde; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005557:Formaldehyde; D002351:Carrageenan