title: Genome organization and molecular analysis of the temperate bacteriophage MM1 of Streptococcus pneumoniae.
abstract: The genome of MM1 (40,248 bp), a temperate bacteriophage from the Spain(23F)-1 multiresistant epidemic clone of Streptococcus pneumoniae, is organized in 53 open reading frames (ORFs) and in at least five functional clusters. Bioinformatic and N-terminal amino acid sequence analyses enabled the assignment of possible functions to 26 ORFs. Analyses comparing the MM1 genome with those of other bacteriophages revealed similarities, mainly with genomes of phages infecting gram-positive bacteria, which suggest recent exchange of genes between species colonizing the same habitat.
authors.affiliation: Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC, 28006 Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Obregón
authors.forename: José L
authors.initials: JL
authors.lastname: García
authors.forename: Ernesto
authors.initials: E
authors.lastname: García
authors.forename: Rubens
authors.initials: R
authors.lastname: López
authors.forename: Pedro
authors.initials: P
authors.lastname: García
mesh_terms: D023061:Gene Order; D005815:Genetic Code; D016679:Genome, Viral; D008242:Lysogeny / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D017422:Sequence Analysis, DNA; D017108:Streptococcus Phages / Q000235:genetics*; D013296:Streptococcus pneumoniae / Q000821:virology; D014779:Virus Replication / Q000235:genetics