Myelin basic protein-reactive T cells induce conduction failure in vivo but not in vitro.
The ability of myelin basic protein (MBP)-reactive T cells to induce conduction failure was investigated and. With the model, somatosensory evoked potentials (SEP) were recorded before and during adoptively transferred experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Maximum amplitude SEP were reached within 15 min of anesthesia. During EAE, the SEP decreased considerably and their onset was delayed. However, the compound action potentials (CAPs) recorded from Lewis rat optic nerves incubated with encephalitogenic T cells were not affected, emphasizing the importance of environmental factors. This study shows that the model described here is an useful means of investigating the neurological disorders associated with EAE.
Devaux
Jérôme
J
Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, FRE 2131, CNRS, 31, Chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France.
Forni
Claude
C
Beeton
Christine
C
Barbaria
Jocelyne
J
Béraud
Evelyne
E
Gola
Maurice
M
Crest
Marcel
M
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D004676:Myelin Basic Protein / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000502:physiology*
D004676:Myelin Basic Protein