title: [Pharmacogenetics--pathway to individualized antihypertensive pharmacotherapy].
abstract: The variations in response to pharmacotherapy can in part be explained by genetic factors. Pharmacogenetics, a term coined in the 1950's, describes these relationships. Great technological advances in molecular biology and computational sciences, crowned by the sequencing of the human genome, have brought forth the current interest in pharmacogenetics. Continued technological developments may lead to the understanding of the molecular mechanisms behind complex diseases like cardiovascular disease, and holds the promise of individualized pharmacotherapy. The article gives a background to the field, with emphasis on antihypertensive therapy, and prospects for the future.
authors.affiliation: Medicincentrum, Akademiska sjukhuset, Uppsala. lisa.kurland@medsci.uu.se
authors.forename: Lisa
authors.initials: L
authors.lastname: Kurland
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.forename: Hans
authors.initials: H
authors.lastname: Lithell
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Syvänen
authors.forename: Håkan
authors.initials: H
authors.lastname: Melhus
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001711:Biotransformation / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
chemical_list: D000959:Antihypertensive Agents; D003577:Cytochrome P-450 Enzyme System