title: SSRIs antidepressant activity is influenced by G beta 3 variants.
abstract: The aim of the present study was to test a possible effect of the G-protein beta3-subunit (Gbeta3) C825T gene variant on the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) in a sample of major and bipolar depressives, with or without psychotic features. Four hundred and ninety inpatients were treated with fluvoxamine 300 mg/day (n=362) or paroxetine 40 mg/day (n=128) and either placebo or pindolol in a double-blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. Gbeta3 allelic variants were determined in each subject using a PCR-based technique. Subjects with Gbeta3 T/T variants showed better response to treatment (P=0.009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments.
authors.affiliation: Department of Psychiatry, Vita-Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy. serretti.alesandro@hsr.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Cristina
authors.initials: C
authors.lastname: Lorenzi
authors.forename: Cristina
authors.initials: C
authors.lastname: Cusin
authors.forename: Raffaella
authors.initials: R
authors.lastname: Zanardi
authors.forename: Enrico
authors.initials: E
authors.lastname: Lattuada
authors.forename: David
authors.initials: D
authors.lastname: Rossini
authors.forename: Roberta
authors.initials: R
authors.lastname: Lilli
authors.forename: Adele
authors.initials: A
authors.lastname: Pirovano
authors.forename: Marco
authors.initials: M
authors.lastname: Catalano
authors.forename: Enrico
authors.initials: E
authors.lastname: Smeraldi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000187:drug effects / Q000502:physiology*; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D020962:Heterotrimeric GTP-Binding Proteins; D021122:Protein Subunits; D017367:Selective Serotonin Reuptake Inhibitors; C454420:G-protein beta3 subunit