title: Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus.
abstract: OBJECTIVE
  The association of bone mineral density (BMD) with diffuse idiopathic skeletal hyperostosis (DISH) related to diabetes mellitus was studied.
  
  
  METHODS
  We measured BMD and elevated known determinants of BMD (bone markers) in 35 patients with DISH-related type 2 diabetes mellitus, 47 type 2 female diabetics, and 52 female controls with no systemic disease and no drug administration. All subjects were matched for age and body mass index (BMI). All subjects were in the postmenopausal period.
  
  
  RESULTS
  Among subjects, BMD values were significantly higher in DISH patients than in diabetics and controls (p < 0.05). In addition, the duration of diabetes mellitus was longer in DISH patients and significantly correlated with total hip BMD in DISH patients (p < 0.05).
  
  
  CONCLUSIONS
  Patients with DISH have higher BMD, and increased BMD probably results from hyperostosis of the axial skeleton, which may cause decreased fracture risk.
authors.affiliation: Mersin University, Faculty of Medicine, Department of PMR, Mersin, Turkey. gunsahsahin@hotmail.com
authors.forename: Günsah
authors.initials: G
authors.lastname: Sahin
authors.forename: Gürbüz
authors.initials: G
authors.lastname: Polat
authors.forename: Selda
authors.initials: S
authors.lastname: Bagis
authors.forename: Abtullah
authors.initials: A
authors.lastname: Milcan
authors.forename: Canan
authors.initials: C
authors.lastname: Erdogan
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000652:urine; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D005269:Femur / Q000502:physiology; D006615:Hip / Q000502:physiology; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000503:physiopathology*; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D002118:Calcium