title: Expanding the physiological role of the hexameric DnaB helicase.
abstract: The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.
authors.affiliation: Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch at Galveston, 77555-1053, USA. wbujalow@utmb.edu
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Bujalowski
mesh_terms: D001426:Bacterial Proteins; D004265:DNA Helicases / Q000737:chemistry* / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D053488:DnaB Helicases; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D011995:Recombination, Genetic; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D021122:Protein Subunits; D004265:DNA Helicases; D053488:DnaB Helicases