[Pregnancy induced arterial hypertension--an attempt to evaluate hermetic aspects of the blood-brain barrier connected with skull computed tomography].
The aim of the work was to study the influence of pregnancy induced arterial hypertension (PIH) on hermetic aspects of the blood-brain barrier. Neurological consultation was followed by cranial computed tomography which revealed changes within structures of central nervous system. The observations were performed in 6 pregnant women, assigned to control group--C, and study group--G. All women had caesarean section performed in conductive anaesthesia. The method included collection of 15 ml venous blood and 4 ml cerebrospinal fluid (CSF). Albumin and immunoglobulin G (IgG) serum concentrations, micro-albumin and IgG CSF concentrations, and permeability indexes for albumin and IgG--Qalb and QIqG, were estimated. In contrast to group C, increased Qalb and QIgG indexes proved lack of integrity of blood-brain barrier in the group G. Control cranial CT scans revealed partial subsidence of changes after 3-5 days, and complete subsidence after 9-14 days.
Michalska-Krzanowska
Grazyna
G
Oddział Anestezjologii, Reanimacji i Intensywnej Terapii z Pododdziałem Ostrych Zatruć Samodzielny Publiczny Szpital Kliniczny Nr 2 w Szczecinie.
Drobnik
Leon
L
Stasiak-Pikuła
Elzbieta
E
D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000000981:diagnostic imaging / Q000378:metabolism; D012709:Serum Albumin / Q000032:analysis; D019291:Skull Base / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000418:Albumins; D007074:Immunoglobulin G; D012709:Serum Albumin