Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines.
[reaction: see text] An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degrees C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
Kwong
Fuk Yee
FY
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Buchwald
Stephen L
SL
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D017605:Bromine Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*
D000588:Amines; D017605:Bromine Compounds; D003300:Copper