Coronary microembolization.
Atherosclerotic plaque rupture is a key event in the pathogenesis of acute coronary syndromes and during coronary interventions. However, it does not always result in complete thrombotic occlusion of the entire epicardial coronary artery with subsequent acute myocardial infarction; in milder forms the result can be embolization of atherosclerotic and thrombotic debris into the coronary microcirculation. This review summarizes the available morphological evidence for coronary microembolization in patients who died from coronary artery disease, most notably from sudden death, and then goes on to address the experimental pathophysiology of coronary microembolization in animal models of acute coronary syndromes and heart failure. Finally, the review presents the available clinical evidence for coronary microembolization in patients, highlights its key features (ie, arrhythmias, contractile dysfunction, infarctlets and reduced coronary reserve) and addresses its prevention by mechanical protection devices and glycoprotein IIb/IIIa antagonism.
Skyschally
Andreas
A
Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Germany.
Erbel
Raimund
R
Heusch
Gerd
G
D000789:Angina, Unstable / Q000503:physiopathology; D000818:Animals; D002303:Cardiac Output, Low / Q000209:etiology; D002908:Chronic Disease; D003326:Coronary Circulation; D003328:Coronary Thrombosis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology* / Q000517:prevention & control; D004195:Disease Models, Animal; D004617:Embolism / Q000150:complications / Q000473:pathology* / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans