title: [Predictive elements of malignancy of isolated thyroid nodules].
abstract: The clinically revealed thyroid nodules are very frequent (3 to 5% of the general population), among them, fewer than 10% are malignant. The objective of this retrospective study type witness-case is to determinate the malignity predictive clinical and paraclinical elements for 45 patients presenting a thyroid malignant nodule and 45 others matched by age and sex presenting a thyroid isolated nodule. These patients were treated at the ORL ward of Charles Nicolle Hospital over a period of 10 years from 1989 to 1999. The average age of advent of malignant nodule is 43.2 + 14.4 years old with a clear female predominance (sex ratio = 4). The elements clearly linked to the hazard of thyroid cancer are loss of weight (p = 0.05; OR = 8.11), hard consistency of nodule (p = 0.002), the presence of cervical adenopathies (p = 0.05; OR = 4.22), vocal cords paralysis (p = 0.04), the presence of anemia (p = 0.01; OR = 5.7), a solid structure at sonography (p = 0.05) and the presence of a flux at doppler-sonography (p = 0.02). Personal antecedents of non malignant thyroid pathology, the nodule location and size and hypoechogenic features have not been clearly associated with the hazards of thyroid cancer.
authors.affiliation: Service de médecine interne B-unité d'endocrinologie B.
authors.forename: Meriem
authors.initials: M
authors.lastname: Naouar
authors.forename: Hédia
authors.initials: H
authors.lastname: Slimene
authors.forename: Merfet
authors.initials: M
authors.lastname: Kamoun
authors.forename: Hafaoua
authors.initials: H
authors.lastname: Abid
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ferjaoui
authors.forename: Ali
authors.initials: A
authors.lastname: Haddad
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000473:pathology*; D016606:Thyroid Nodule / Q000150:complications / Q000473:pathology*; D015431:Weight Loss