Heparin-induced thrombocytopenia with associated thrombosis in children after the Fontan operation: report of two cases.
Heparin-induced thrombocytopenia is a widely recognized clinical disorder. The spectrum of disease ranges from clinically insignificant to severe thrombosis (heparin-induced thrombocytopenia with associated thrombosis). Overall, thrombosis occurs in approximately 33% of adults diagnosed with heparin-induced thrombocytopenia and has been associated with high morbidity and mortality rates. Diagnostic testing for this disorder is not standard in children with thrombocytopenia who are receiving heparin, despite the fact that children with congenital heart disease may be exposed to heparin frequently. There are few reported cases of heparin-induced thrombocytopenia with associated thrombosis in children; herein, we describe the cases of 2 children who developed this disorder after undergoing a Fontan operation.
Porcelli
Rosalia
R
Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Moskowitz
Bonnie C
BC
Cetta
Frank
F
Graham
Lynn C
LC
Godwin
John E
JE
Eidem
Benjamin W
BW
Prechel
M Margaret
MM
Walenga
Jeanine M
JM
D000925:Anticoagulants / Q000009:adverse effects*; D002675:Child, Preschool; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000601:surgery*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications* / Q000175:diagnosis; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology*
D000925:Anticoagulants; D006493:Heparin