The importance of being outer: consequences of the distinction between the outer and inner surfaces of flavivirus glycoprotein E.
Glycoprotein E of West Nile, dengue and other flaviviruses is the principal stimulus for the development of neutralizing antibodies and contains a fusion peptide responsible for inserting the virus into the host cell membrane. This glycoprotein lies flat on the surface of the virion and therefore only epitopes on the outer or lateral surface are important immunogens. Changes in antigen recognition after exposure of the virus to low pH have yielded clues to the fusion process.
Seligman
Stephen J
SJ
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. stephen_seligman@nymc.edu
Bucher
Doris J
DJ
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D005416:Flavivirus / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D008561:Membrane Fusion; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D014759:Viral Envelope Proteins; C065696:glycoprotein E, Flavivirus