Notch signalling in the regulation of peripheral T-cell function.
The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway's role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function.
Mckenzie
Grahame J
GJ
Lorantis Ltd, 307 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK. grahame.mckenzie@lorantis.com
Young
Lesley L
LL
Briend
Emmanuel
E
Lamb
Jonathan R
JR
Dallman
Margaret J
MJ
Champion
Brian R
BR
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch