The complex nature of protein phosphatases.
Protein phosphatases are integrally associated with the regulation of cellular signaling. The mechanisms underlying the specific regulatory roles are likely to be unique to each cell system. Nevertheless, analysis of phosphatase regulation in a number of systems has identified phosphatase targeting through association with a wide range of binding partners to be a fundamental mechanism of regulation. Using protein phosphatase 2A (PP2A) as an example, this snapshot summarizes these fundamental mechanisms of protein phosphatase regulation.
Sim
Alistair T R
AT
School of Biomedical Sciences. Faculty of Health Sciences, The University of Newcastle, NSW 2308, Australia. Alistair.sim@newcastle.edu.au
Ludowyke
Russell I
RI
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D054648:Protein Phosphatase 2; D020836:Protein Structure, Quaternary; D015398:Signal Transduction
D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2