Effect of vitamin D3 on the conversion of ethylene glycol to glycolate and oxalate in ethylene glycol-fed rats.
Hypercalciuria and hyperoxaluria are important risk factors in the pathogenesis of kidney stones. Urinary glycolate has also been reported to be elevated in patients with renal stones. 1,25-Dihydroxyvitamin D(3), the active metabolite of vitamin D, has been reported to induce hyperoxaluria after either oral or intravenous administration. 1-alpha-D(3), a synthetic derivative of vitamin D, together with ethylene glycol, has been reported to induce renal stones in experimental rats. We have examined the effect of 1-alpha-vitamin D(3) on urinary oxalate and glycolate excretion. Our results indicate that 1-alpha-D(3), together with ethylene glycol, caused a significant increase in urinary glycolate, without a parallel rise in urinary oxalate excretion, in ethylene glycol-fed rats. This increase in urinary glycolate was due to the synergistic effect of both drugs.
Halabe
A
A
Department of Internal Medicine, Edith Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Holon 58100, Israel.
Shor
R
R
Wong
N L M
NL
Sutton
R A L
RA
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D004357:Drug Synergism; D019855:Ethylene Glycol / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D006016:Glycolates / Q000633:toxicity / Q000652:urine*; D007274:Injections, Intraperitoneal; D007669:Kidney Calculi / Q000139:chemically induced / Q000652:urine; D008297:Male; D010070:Oxalates / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*
D002250:Carbon Radioisotopes; D006016:Glycolates; D010070:Oxalates; C118756:dihydroxy-vitamin D3; C031149:glycolic acid; D014807:Vitamin D; D019855:Ethylene Glycol