title: Non-linear dynamic analysis of hemodynamic parameters in an undulation type artificial heart system.
abstract: Undulation pump total artificial heart (UPTAH) is a unique total artificial heart implant (TAH) using an undulation pump that is a continuous blood flow pump. To evaluate the autonomic nerve function mediating the circulation system, we analyzed the hemodynamic parameters during animal experiments with UPTAH using the non-linear mathematical analyzing technique, including chaos and fractal theory. Adult female goats were used for the implantation of UPTAH. The natural heart was replaced with UPTAH under extra-corporal circulation. The conductance- and arterial pressure-based control method (1/R control) was applied on the 5th to 7th post-operative day as the influences of the cardiopulmonary bypass circulation were diagnosed to be terminated. Hemodynamic parameters were recorded on the data recorder, and non-linear mathematical analysis was performed. For the quantitative evaluation of the strange attractor, which was the characteristics of the deterministic chaos, the fractal dimension analysis was carried out. As a result, hemodynamic parameters fluctuated on the time axis and showed fractal characteristics, which were thought to be the characteristics of the deterministic chaos. The reconstructed attractor of the hemodynamics showed various behaviors according to changes in the situation of the goats. These results suggest that non-linear dynamical analysis might be useful in monitoring the circulatory regulatory system in artificial heart circulation.
authors.affiliation: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. yambe@idac.tohoku.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Takashi
authors.initials: T
authors.lastname: Isoyama
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tabayashi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nanka
authors.forename: Kou
authors.initials: K
authors.lastname: Imachi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nitta
mesh_terms: D000818:Animals; D005260:Female; D006041:Goats; D006354:Heart, Artificial / Q000706:statistics & numerical data*; D006439:Hemodynamics / Q000502:physiology*; D017711:Nonlinear Dynamics