[Therapeutic drug monitoring in depression--new perspectives].
34 patients with diagnosis of depressive episode (ICD-10) were treated for 8 weeks with tricyclic antidepressants (TCA) 22 patients were treated with clomipramine 75-175 mg daily, 11 with imipramine 75-150 mg and 1 with amitriptyline 150 mg. Following parameters were analysed: plasma concentration (FPIA, HPLC), pharmaco-EEG (spectrum power for delta, theta, alfa1, 2, beta 1, 2, 3 by the use of FFT), clinical improvement (HAMD, HARS, SGI, SERS). 50% reduction in HAMD was regarded as improvement.


RESULTS
No relationship between mental state and plasma concentration of TCA was found, initial results in SERS were prognostic for the course of treatment, pharmaco-EEG was typical for antidepressants after two weeks of treatment and reflects clinical improvement and stabilization of plasma concentration. Comparing the plasma concentration of TCA measured by the use of FPIA and HPLC method may be useful for the implementation of monitoring therapy.
Radziwoń-Zaleska
Maria
M
Katedra i Klinika Psychiatryczna Akademii Medycznej w Warszawie.
Matsumoto
Halina
H
Skalski
Michał
M
Dziklińska
Anna
A
Androsiuk
Wojciech
W
Wakarow
Andrzej
A
Wilkowska
Joanna
J
Matoszko
Daria
D
Kuczyńska
Julita
J
Goluch
Justyna
J
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000008:administration & dosage / Q000097:blood*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000008:administration & dosage / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013997:Time Factors; D016896:Treatment Outcome
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D002997:Clomipramine; D007099:Imipramine