title: Molecular characterization and antimicrobial susceptibility of fluoroquinolone-resistant or -susceptible Streptococcus pneumoniae from Hong Kong.
abstract: Fluoroquinolone resistance in Streptococcus pneumoniae isolated from Hong Kong as part of Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin 1999/2000 was found to be due to the spread of the Spain(23F)-1 clone (mainly a Spain(23F)-1-14 variant). All the isolates were multidrug resistant but were susceptible to quinupristin-dalfopristin, linezolid, and telithromycin. The Spain(23F)-1 clone also occurred among antimicrobial-susceptible isolates, which suggests that the primary source of this clone may have been Asia rather than Iberia.
authors.affiliation: GR Micro Ltd., London, United Kingdom. i.morrissey@grmicro.co.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Morrissey
authors.forename: David J
authors.initials: DJ
authors.lastname: Farrell
authors.forename: Sarah
authors.initials: S
authors.lastname: Bakker
authors.forename: Sylvie
authors.initials: S
authors.lastname: Buckridge
authors.forename: David
authors.initials: D
authors.lastname: Felmingham
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones; D006723:Hong Kong; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones