title: The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.
abstract: We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)-1 and TREM2, the cluster contains NKp44, a triggering receptor whose expression is limited to NK cells. We identified three new related genes and two gene fragments within a cluster of approximately 200 kb. Two of the three new genes lack charged residues in their transmembrane domain tails. Further, one of the genes contains two potential immunotyrosine Inhibitory motifs in its cytoplasmic tail, suggesting that it delivers inhibitory signals. The human and mouse TREM clusters appear to have diverged such that there are unique sequences in each species. Finally, each gene in the TREM cluster was expressed in a different range of cell types.
authors.affiliation: Cambridge Institute for Medical Research, Wellcome Trust/MRC building, Addenbrookes Hospital, Cambridge, GB.
authors.forename: Richard J N
authors.initials: RJ
authors.lastname: Allcock
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Barrow
authors.forename: Simon
authors.initials: S
authors.lastname: Forbes
authors.forename: Stephan
authors.initials: S
authors.lastname: Beck
authors.forename: John
authors.initials: J
authors.lastname: Trowsdale
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D019143:Evolution, Molecular; D005091:Exons / Q000235:genetics; D020224:Expressed Sequence Tags; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007438:Introns / Q000235:genetics; D020084:Long Interspersed Nucleotide Elements; D008562:Membrane Glycoproteins; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D055629:Natural Cytotoxicity Triggering Receptor 2; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D011544:Pseudogenes / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D020298:U937 Cells / Q000737:chemistry
chemical_list: D007135:Immunoglobulin Variable Region; D008562:Membrane Glycoproteins; C112837:NCR2 protein, human; D055629:Natural Cytotoxicity Triggering Receptor 2; D012333:RNA, Messenger; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; C498715:TREM2 protein, human; C473366:TREML1 protein, human; C473367:TREML2 protein, human; C473368:TREML3P protein, human; C498716:Trem2 protein, mouse; D000073871:Triggering Receptor Expressed on Myeloid Cells-1