[Regulatory phenomena in tolerance induction].
The implication of regulatory T cells in self-tolerance induction was shown in experimental models based on construction of thymic chimera and peripheric T cell transfers. The role played by the epithelial stroma of the thymus in CD4+ regulatory T cell selection was demonstrated. In the NOD (Non Obese Diabetic) strain, protection again diabetes was obtained by grafting supplementary thymuses injected with allogeneic pancreatic islets. This result suggest that the NOD thymuses are defective in the production of T regulatory cells.
Salaün
Josselyne
J
Laboratoire d'Embryologie cellulaire et moléculaire, 49 bis, av. de la Belle Gabrielle, 94736 Nogent s/Marne. josselyne.salaun@college-de-france.fr
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D016381:Islets of Langerhans Transplantation; D051379:Mice; D016688:Mice, Inbred NOD; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000637:transplantation; D013950:Thymus Gland / Q000276:immunology / Q000637:transplantation; D018183:Transplantation Chimera