The role of interleukin-6 in nociception and pain.
That IL-6 is an interesting target in the study of pain is underscored by its biomolecular properties, its localization after experimental pain, and its modulating effect on pain after administration.
De Jongh
Raf F
RF
*Department of Anesthesia, Intensive Care, and Emergency Care and the Multidisciplinary Pain Centre, Ziekenhuis Oost Limburg, Genk, Belgium; †Johnson & Johnson, Pharmaceutical Research and Development, Beerse, Belgium; and ‡Department of Anesthesia, University Hospital of Nijmegen, Nijmegen, The Netherlands.
Vissers
Kris C
KC
Meert
Theo F
TF
Booij
Leo H D J
LHDJ
De Deyne
Catharina S
CS
Heylen
René J
RJ
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology*; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000378:metabolism / Q000503:physiopathology*
D018836:Inflammation Mediators; D015850:Interleukin-6