title: Receptor sensitivity: when T cells lose their sense of self.
abstract: The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.
authors.affiliation: University of Minnesota, Center for Immunology, 312 Church Street, S.E., Minneapolis, Minnesota 55455, USA. hogqu001@umn.edu
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Hogquist
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Starr
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Jameson
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008024:Ligands; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
chemical_list: D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D008024:Ligands; D011948:Receptors, Antigen, T-Cell