[Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
OBJECTIVE
A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population.


METHODS
A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanish population to estimate its prevalence. Two independently collected samples consisting of 486 subjects (sample 1) and 514 subjects (sample 2) were studied. The Leu7Pro polymorphism was determined.


RESULTS
We found only one individual carrying the Leu7Pro variant (0.1%). The allele frequency of the Pro7 allele was extremely low: 0.005 (95% CI,0.0001-0.0015).


CONCLUSIONS
This low prevalence suggests that the Pro7 allele is not one of the genetic determinant factors affecting obesity, plasma lipids or alcoholism in this population.
Portolés
Olga
O
Unidad de Epidemiología Genética y Molecular, Departamento de Medicina Preventiva y Salud Pública, Universitat de València, València, España. olga.portoles@uv.es
Sorlí
José Vicente
JV
González
José Ignacio
JI
Ruiz de la Fuente
Salvador
S
Ramírez
Judith Begoña
JB
Corella
Dolores
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007930:Leucine; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D009765:Obesity / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D011392:Proline; D011498:Protein Precursors / Q000235:genetics*; D013030:Spain / Q000453:epidemiology
D008055:Lipids; D009478:Neuropeptide Y; D011498:Protein Precursors; C042084:preproneuropeptide Y; D011392:Proline; D007930:Leucine