Early radiation-induced malignant fibrous histiocytoma of the oral cavity.
With an incidence of less than 0.3 per cent, post-radiation sarcomas are rare malignant neoplasms with a very poor prognosis. On average, they occur after a latency period of at least 15 years following radiation therapy with doses ranging from 24 to 80 Gy. We present the case of a post-irradiation malignant fibrous histiocytoma (MFH) on the floor of the mouth in a 79-year-old male patient arising only five and a half years after radiation therapy. The primary tumour was classified as a well differentiated squamous cell carcinoma of the right rim of the tongue. Primary therapy was surgical resection of the tumour and post-operative radiation with 50 Gy. Five and a half years later, the patient developed a rapidly progressing MFH within the field of radiation.
Wiesmiller
Kerstin
K
Department of Otorhinolaryngology, University of Ulm, Ulm, Germany. kerstin.weismiller@medizin.uni-ulm.de
Barth
Thomas F E
TF
Gronau
Silke
S
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000209:etiology / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology*; D014062:Tongue Neoplasms / Q000532:radiotherapy / Q000601:surgery