Tumoricidal activity of lauryl gallate towards chemically induced skin tumours in mice.
Lauryl gallate (antioxidant food additive E-312) prevents the formation of dimethylbenzanthracene-induced skin tumours in mice, and kills, selectively, tumoral cells on established tumours. This results in total remission, after topical application of the compound on the tumoral mass, without affecting the surrounding tissue.
Ortega
E
E
Servicios de Inmunologia, Hospital Ramón y Cajal, Ctra. Colmenar Km 9, Madrid, Spain.
Sadaba
M C
MC
Ortiz
A I
AI
Cespon
C
C
Rocamora
A
A
Escolano
J M
JM
Roy
G
G
Villar
L M
LM
Gonzalez-Porque
P
P
D000818:Animals; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000662:veterinary
D005503:Food Additives; C008259:lauryl gallate; D005707:Gallic Acid