title: Intracranial chloroma in hypereosinophilic myelofibrosis.
abstract: BACKGROUND
  Chloroma, also called granulocytic sarcoma, is a localized extramedullary tumor composed of leukemic myeloid cells. It is a rare tumor that can occur in various locations. The association of chloroma with leukemic disease or myeloproliferative disorders is limited to isolated case reports.
  
  
  METHODS
  We report a case of intracranial chloroma in an elderly man with myelofibrosis and progressive hypereosinophilia. The presence of leukemic cells within his pleural aspirate suggested an incipient acute leukemic state.
  
  
  CONCLUSIONS
  We report the first case of intracranial chloroma associated with hypereosinophilia developing in the course of myelofibrosis. The significance of hypereosinophilia in predicting the likelihood of development of central nervous system chloroma and acute leukemia in a patient with myelofibrosis needs further evaluation.
authors.affiliation: Department of Surgery, United Christian Hospital, Room 5C, Block G, Hip Wo Street, Kwun Tong, Hong Kong Special Administrative Region (HKSAR), China.
authors.forename: Sharon W W
authors.initials: SW
authors.lastname: Chan
authors.forename: N N
authors.initials: NN
authors.lastname: Datta
authors.forename: Teresa M M
authors.initials: TM
authors.lastname: Thomas
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
mesh_terms: D000208:Acute Disease; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D007938:Leukemia / Q000150:complications; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology; D013902:Radiography, Thoracic; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed