Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis.
Immunization via the oral route with an attenuated Yersinia enterocolitica strain expressing a fragment of the measles virus nucleocapsid protein (aa 79-161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.
Gundel
Iris
I
Institut für Virologie und Immunbiologie, Versbacher Str. 7, 97078 Würzburg, Germany.
Weidinger
Gerald
G
Institut für Virologie und Immunbiologie, Versbacher Str. 7, 97078 Würzburg, Germany.
Ter Meulen
Volker
V
Institut für Virologie und Immunbiologie, Versbacher Str. 7, 97078 Würzburg, Germany.
Heesemann
Jürgen
J
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, München, Germany.
Rüssmann
Holger
H
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, München, Germany.
Niewiesk
Stefan
S
Institut für Virologie und Immunbiologie, Versbacher Str. 7, 97078 Würzburg, Germany.
D000284:Administration, Oral; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D018792:Encephalitis, Viral / Q000517:prevention & control*; D018984:Epitopes, T-Lymphocyte / Q000008:administration & dosage* / Q000096:biosynthesis / Q000235:genetics; D005822:Genetic Vectors; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D018103:Morbillivirus / Q000276:immunology; D019590:Nucleocapsid Proteins / Q000096:biosynthesis / Q000235:genetics; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D015008:Yersinia enterocolitica / Q000378:metabolism*
D000945:Antigens, Differentiation, T-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D008458:Measles Vaccine; D019590:Nucleocapsid Proteins; D014614:Vaccines, Synthetic