[New inflammation modulator interleukins . Therapeutic implications].
A lot of different leukocyte recruit soluble factors are implicated in both acute and chronic inflammatory processes with a higher expression of the cellular adhesion and chemoattraction molecules. Soluble factors implicated in these processes include: lipid inflammatory metabolites, arachydonic acid derivatives (prostaglandines, leucotrienes, lipoxines, PAF), the three soluble proteases waterfall events/substrates (coagulation, complement, kinines), nitric oxide, as well as cytokines implicated in acute or chronic inflammatory and cellular immune reactions. Recently, new inflammation modulator cytokines were described: IL-20, IL-21, IL-22 and IL-23. The aim of this work was to present some theoretical aspects regarding the biological effects of these new cytokines implicated in inflammation and the pharmacological influence of the processes mediated by them. Particularly IL-20 is implicated in psoriasis pathology. IL-21 and IL-15 are important in NK cells differentiation. IL-22 regulates the IL-4 production from Th2T cells. IL-23 stimulates IFN gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.
Lupuşoru
Catălina Elena
CE
Diciplina de Farmacologie-Toxicologie-Algeziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Tarţău
Liliana
L
Ghiciuc
Cristina
C
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000628:therapy; D053759:Interleukin-23; D053760:Interleukin-23 Subunit p19; D007378:Interleukins / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D011565:Psoriasis / Q000276:immunology / Q000628:therapy; D000097043:Interleukin-22; D000098546:Interleukin-21
D053759:Interleukin-23; D053760:Interleukin-23 Subunit p19; D007378:Interleukins; D000097043:Interleukin-22; D000098546:Interleukin-21; C508840:IL23A protein, human; C508841:Il23a protein, mouse; C422042:interleukin 20