title: [Graves' disease in patients with Down syndrome].
abstract: Three patients showing the rare association of Down syndrome and Graves' disease are reported. While two of the patients were asymptomatic, the third showed goiter, nervousness, weight loss, and tachycardia. In addition to the typical features of hyperthyroidism, this patient showed right heart failure and hypertransaminasemia, which disappeared with antithyroid treatment. Because Graves' disease is rare in children, and the clinical presentation was unusual in one of our patients, we report three patients with Graves' disease and Down syndrome, and emphasize the importance of periodic evaluation of thyroid function in children with Down syndrome not only to detect hypothyroidism.
authors.affiliation: Seccion de Endocrinología. Universidad Autónoma de Madrid. Departamento de Pediatría. Hospital Infantil Universitario del Niño Jesús. Madrid. España.
authors.forename: L
authors.initials: L
authors.lastname: Soriano Guillén
authors.forename: M T
authors.initials: MT
authors.lastname: Muñoz Calvo
authors.forename: J
authors.initials: J
authors.lastname: Pozo Román
authors.forename: J
authors.initials: J
authors.lastname: Martínez Pérez
authors.forename: A
authors.initials: A
authors.lastname: Baño Rodrigo
authors.forename: J
authors.initials: J
authors.lastname: Argente Oliver
mesh_terms: D000293:Adolescent; D002648:Child; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006111:Graves Disease / Q000209:etiology*; D006801:Humans; D008297:Male