title: Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection.
abstract: Establishing persistent infection and resisting elimination by the host's immune system are key factors contributing to latent infection by Mycobacterium tuberculosis. Recently, bacterial determinants regulating these processes have been identified. Here, we review molecular mechanisms regulating persistent infection and discuss the highly dynamic interaction of M. tuberculosis with the host.
authors.affiliation: Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226-0509, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Zahrt
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002353:Carrier State / Q000276:immunology* / Q000382:microbiology; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D006099:Granuloma / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins