[Phenotypic expression of the mutant gene diabetes insipidus in rats and criteria of genotyping by phenotype].
The autosomal semidominant mutant gene di (diabetes insipidus) is manifested in homozygotes in the form of diabetes insipidus with water consumption from 25 to 100% of body weight per day. The heterozygotes di/+ drink water at a rate higher than 5% but lower than 25%. The level of water consumption in rats with +/+ genotype does not exceed 5% of body weight per day. Segregation analysis of F1 animals yielded by various crosses showed that genotyping of di/di homozygotes is absolutely reliable at 30% and higher level of the water consumption per day.
Khegaĭ
I I
II
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia. khegay@bionet.nsc.ru
D000818:Animals; D003433:Crosses, Genetic; D003919:Diabetes Insipidus / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D004326:Drinking; D015870:Gene Expression; D005838:Genotype; D006720:Homozygote; D009154:Mutation; D010641:Phenotype; D051381:Rats; D011910:Rats, Brattleboro; D015203:Reproducibility of Results; D014867:Water / Q000378:metabolism
D014867:Water