Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis.
We show that treating human trisomic fibroblasts with anthracyclines - aclarubicin, daunorubicin and idarubicin - leads to certain changes in these cells; namely the activation of caspase 3, morphological changes and an increase in the level of intracellular calcium. These results suggest that anthracycline drugs are also able to induce apoptosis in pathological, trisomic cells.
Kania
Katarzyna
K
Department of Thermobiology, University of Łódź, Banacha 12/16, Poland.
Dragojew
Sylwia
S
Jóźwiak
Zofia
Z
D015250:Aclarubicin / Q000494:pharmacology; D018943:Anthracyclines / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D003630:Daunorubicin / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015255:Idarubicin / Q000494:pharmacology; D007424:Intracellular Fluid / Q000187:drug effects / Q000378:metabolism; D014314:Trisomy
D018943:Anthracyclines; D015250:Aclarubicin; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D002118:Calcium; D015255:Idarubicin; D003630:Daunorubicin