title: The vestibulo-ocular reflex of hypergravity rats.
abstract: The vertebrate vestibular system detects linear (otolith organs) and angular (semicircular canals) acceleration. The function of the otolith system is twofold, 1: perception of linear acceleration of the head, and 2: assessment of the spatial orientation of the head relative to the vector of gravity. Because of the latter function, a change of gravity will affect the vestibular input which, in turn, may have a wide range of serious physiological effects, for instance on ocular reflexes. The function of the vestibulo-ocular reflex (VOR) is to stabilize the visual image on the retina. Measurement of this VOR provides a method to investigate the (processing within the) vestibular system. Discrimination between gravity and linear acceleration, caused by movement of the head, is not possible. Therefore, information from the otolith system must be constantly compared with additional information from other sensory systems in order to solve the inherent ambiguity between tilt and translation. In this processing, cues from the semicircular canals also play a role. During parabolic flight, experiments can be performed at altered gravity levels for brief periods of time. On earth, the only effective possibility to manipulate gravity for longer periods of time is a centrifuge. Together with experiments in weightlessness during orbital flight, these methods form useful tools to investigate the influence of gravity on physiology. In our laboratory, rats have been kept inside a centrifuge at 2.5 g during their entire life-span (i.e. including gestation).
authors.affiliation: Vestibular Department ENT, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wubbels
authors.forename: H A
authors.initials: HA
authors.lastname: de Jong
mesh_terms: D000054:Acceleration; D000818:Animals; D002498:Centrifugation; D005133:Eye Movements / Q000502:physiology*; D018471:Hypergravity; D051381:Rats; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013026:Space Flight; D014722:Vestibule, Labyrinth / Q000196:embryology / Q000254:growth & development* / Q000502:physiology; D014893:Weightlessness