Long-term follow up study of vertical HTLV-I infection in children breast-fed by seropositive mothers.
Infection of Human T-lymphotropic virus type-I (HTLV-I) was investigated by long-term follow up surveys of mother's milk-fed infants. HTLV-I infections of infants via seropositive mother's milk, that is, anti-HTLV-I antibody-positive infants, increased in number up to the age 2, but no infants became antibody-positive thereafter. Infants who had became antibody positive by age 2 remained so at age 11-12. HTLV-I infection via feeding with mother's milk was established by the age 2. While in epidemiologic surveys an increase of the anti-HTLV-I antibody-positive rate has been reported, this survey revealed that after acquisition of HTLV-I from breast feeding, there was no further horizontal transmission prior to puberty.
Ando
Y
Y
Wakayama Medical University, Kihoku Hospital, Obstetrics and Gynecology, Myoji 219, Katsuragi, Ito, Wakayama, 649-7113, Japan. yando@wakayama-med.ac.jp
Matsumoto
Y
Y
Nakano
S
S
Saito
K
K
Kakimoto
K
K
Tanigawa
T
T
Ekuni
Y
Y
Kawa
M
M
Toyama
T
T
D001942:Breast Feeding; D015480:Deltaretrovirus Antibodies / Q000097:blood*; D005260:Female; D006679:HIV Seropositivity / Q000097:blood; D015490:HTLV-I Infections / Q000276:immunology / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008137:Longitudinal Studies
D015480:Deltaretrovirus Antibodies