Endometrial hyperplasia with secretory changes.
OBJECTIVE
Secretory changes in endometrial hyperplasia are uncommon. The aim of this study is to review the morphologic and clinical findings of 24 cases of endometrial hyperplasia with secretory changes.


METHODS
In 24 patients diagnosed with endometrial hyperplasia with secretory changes during 6 years, clinical characteristics such as menopausal status and hormone treatment were correlated with morphological features. A matched age control group of 24 women with conventional endometrial hyperplasia was used to compare the hormonal effect.


RESULTS
Nineteen patients were premenopausal. Nine women showed simple hyperplasia without atypia and 15 complex hyperplasia, 7 of them with atypia. Seventeen women were under hormonal treatment at the time of diagnosis, 10 of them with progestins. In 7 patients endometrial adenocarcinoma could be seen, 5 coexisting with endometrial hyperplasia with secretory changes and in 2 appearing after 1 and 4 months. In control group only 2 patients were undergoing progestin hormonal treatment.


CONCLUSIONS
Secretory changes can be found in hyperplastic endometrium, particularly in premenopausal women under hormonal treatment with progestins, with the risk of misdiagnosis.
Tresserra
Francisco
F
Department of Pathology, Instituto Universitario Dexeus, 08017, Barcelona, Spain. 25865ftc@comb.es
Lopez-Yarto
Maite
M
Grases
Pedro J
PJ
Ubeda
Alicia
A
Pascual
Maria A
MA
Labastida
Ramon
R
D000328:Adult; D004714:Endometrial Hyperplasia / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D004717:Endometrium / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011372:Progestins / Q000627:therapeutic use
D011372:Progestins