Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis.
A beta-cyclodextrin substituted by an imidazole-bound histamine (CDmh) was successfully used to separate underivatised tryptophan racemate in capillary electrophoresis in the presence of copper(II) ion by the ligand exchange mechanism. To the best of our knowledge, this is the first example of a cyclodextrin derivative behaving as the first coordination sphere ligand in the complex added to the background electrolyte (BGE).
Cucinotta
Vincenzo
V
Department of Chemical Science, University of Catania, viale A. Doria, 6-, 95125 Catania, Italy. ecucinotta@dipchi.unict.it
Giuffrida
Alessandro
A
Grasso
Giulia
G
Maccarrone
Giuseppe
G
Vecchio
Graziella
G
D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods; D008024:Ligands; D013237:Stereoisomerism; D014364:Tryptophan / Q000032:analysis*
D003505:Cyclodextrins; D008024:Ligands; D014364:Tryptophan