An evaluation of the multiple dose protocol of cetrorelix in single ovary women.
BACKGROUND
The ovarian response and the pregnancy outcome of women with one ovary have been investigated under various IVF stimulation protocols. Cetrorelix is a novel agent offering important advantages in ovarian stimulation. In this study, the multiple protocol of cetrorelix is evaluated in single ovary women, for the first time.


METHODS
Retrospective comparison of the ovarian response and ICSI/ET outcome between 12 cycles of single ovary women and 39 cycles of women with two ovaries.


RESULTS
Between the two groups, there were no statistically significant differences in any of the analysed parameters. In the group of single ovary, 2 pregnancies were achieved and 4 children were born. In the group of two ovaries, 10 pregnancies were achieved and nine children were born.


CONCLUSIONS
Single ovary women have the same response to ovarian stimulation with cetrorelix/hMG/rFSH as women having both ovaries, but they present a lower, although not statistically significant, pregnancy rate.
Asimakopoulos
Byron
B
Laboratory of Reproductive Physiology-IVF, Faculty of Medicine, Demokritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.
Nikolettos
Nikos
N
al-Hasani
Safaa
S
Diedrich
Klaus
K
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology* / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix