Home-based study of anti-HIV drug regimen adherence among HIV-infected women: feasibility and preliminary results.
Collection of antiretroviral medication adherence data in the homes of HIV-infected people may have methodological advantages that can improve data quality. However, the feasibility of this approach has not been established. In addition, data on adherence, and its predictors, among HIV-infected women have been limited. Sixty-three HIV-positive women who were prescribed at least one antiretroviral drug in the last month were interviewed in their homes. A standard instrument was used to collect data on all antiretroviral medications prescribed and taken in the three days prior to the interview. Data were also collected on factors thought potentially to affect the ability to be adherent. The results of this study suggest that it is feasible to conduct home-based adherence research. Sixty-seven per cent reported taking all prescribed antiretroviral medication doses. One-third took a sub-optimal dose putting themselves at increased risk of treatment failure and the selection of resistant HIV strains. Unintentional reasons for missing doses were most commonly reported. An ability to describe the intended effect of antiretroviral therapy on HIV viral load was the best predictor of adherence. This finding is consistent with other research suggesting that adherence is associated with an understanding and belief in the effectiveness of antiretroviral therapy.
Durante
A J
AJ
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA. adurante@aecom.yu.edu
Bova
C A
CA
Fennie
K P
KP
Danvers
K A
KA
Holness
D R
DR
Burgess
J D
JD
Williams
A B
AB
D000163:Acquired Immunodeficiency Syndrome / Q000523:psychology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015704:CD4 Antigens / Q000032:analysis; D003430:Cross-Sectional Studies; D005240:Feasibility Studies; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy* / Q000523:psychology / Q000821:virology; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance / Q000523:psychology*; D010865:Pilot Projects; D012944:Social Support; D019562:Viral Load
D019380:Anti-HIV Agents; D015704:CD4 Antigens