title: Reflux oesophagitis in adult coeliac disease: beneficial effect of a gluten free diet.
abstract: BACKGROUND
  Coeliac disease patients show a number of gastrointestinal motor abnormalities, including a decrease in lower oesophageal sphincter pressure. The prevalence of endoscopic oesophagitis in these subjects however is unknown.
  
  
  OBJECTIVE
  To evaluate whether untreated adult coeliac patients had an increased prevalence of reflux oesophagitis and, if so, to assess whether a gluten free diet exerted any beneficial effect on gastro-oesophageal reflux disease (GORD) symptoms.
  
  
  METHODS
  We retrospectively studied 205 coeliac patients (females/males 153/52, median age 32 years) who underwent endoscopy for duodenal biopsy and 400 non-coeliac subjects (females/males 244/156, median age 37 years) referred for endoscopy for upper gastrointestinal symptoms. Each patient was given a questionnaire for evaluation of GORD symptoms prior to and 4-12 months after endoscopy. Coeliac patients were given a gluten free diet. Oesophagitis patients of both groups, following an eight week course of omeprazole, were re-evaluated for GORD symptoms at four month intervals up to one year. Significance of differences was assessed by Fisher's exact test.
  
  
  RESULTS
  Oesophagitis was present in 39/205 (19%, 95% confidence interval (CI) 13.8-25.0%) coeliac patients and in 32/400 (8%, 95% CI 5.5-11.1%) dyspeptic subjects. At the one year follow up, GORD symptoms relapsed in 10/39 (25.6%, 95% CI 13-42.1%) coeliacs with oesophagitis and in 23/32 (71.8%, 95% CI 53.2-86.2%) non-coeliac subjects with oesophagitis.
  
  
  CONCLUSIONS
  Coeliac patients have a high prevalence of reflux oesophagitis. That a gluten free diet significantly decreased the relapse rate of GORD symptoms suggests that coeliac disease may represent a risk factor for development of reflux oesophagitis.
authors.affiliation: Dipartimento di Internistica Clinica e Sperimentale-Gastroenterologia and CIRANAD, Seconda Università di Napoli, Napoli, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cuomo
authors.forename: M
authors.initials: M
authors.lastname: Romano
authors.forename: A
authors.initials: A
authors.lastname: Rocco
authors.forename: G
authors.initials: G
authors.lastname: Budillon
authors.forename: C
authors.initials: C
authors.lastname: Del Vecchio Blanco
authors.forename: G
authors.initials: G
authors.lastname: Nardone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000209:etiology*; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D005983:Glutens / Q000008:administration & dosage*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D005983:Glutens