The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
Pharmacological studies were conducted with the hexane extract of the dry stem of Diospyros variegata Kruz. (Ebenaceae) on experimental animals for evaluating the analgesic, antipyretic and anti-inflammatory activities. In the analgesic test, the hexane extract elicited inhibitory intensity on acetic acid-induced writhing response and on the late phase of formalin test but possessed only a weak effect on the tail-flick response and on the early phase of formalin test. The hexane extract also elicited antipyretic action when tested in yeast-induced hyperthermia in rats. In addition, the hexane extract showed an anti-inflammatory effect when tested in ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced rat ear edema.
Trongsakul
S
S
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand.
Panthong
A
A
Kanjanapothi
D
D
Taesotikul
T
T
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D029788:Diospyros / Q000737:chemistry*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D005557:Formaldehyde; D006586:Hexanes; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D000432:Methanol; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D012997:Solvents
D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D009020:Morphine; D010653:Phenylbutazone; D019342:Acetic Acid; D001241:Aspirin; D000432:Methanol