Influence of hepatitis C virus coinfection on failure of HIV-infected patients receiving highly active antiretroviral therapy to achieve normal serum beta2microglobulin levels.
The influence of hepatitis C virus (HCV) coinfection on the kinetics of serum beta2microglobulin levels in HIV-infected patients undergoing highly active antiretroviral therapy was analyzed. After 96 weeks of therapy, beta2microglobulin levels declined significantly both in 24 HCV seronegative and 16 HCV-infected individuals. Throughout the follow-up period, HCV-infected patients showed higher beta2microglobulin values than non-HCV-infected patients. These results show that HCV infection precludes immune deactivation in HIV-infected patients undergoing highly active antiretroviral therapy.
García-García
J A
JA
Departamento de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz s/n, 41014, Sevilla, Spain.
Mira
J A
JA
Fernández-Rivera
J
J
Ramos
A J
AJ
Vargas
J
J
Macías
J
J
Pineda
J A
JA
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D017211:Treatment Failure; D019562:Viral Load / Q000639:trends; D001613:beta 2-Microglobulin / Q000097:blood*
D012367:RNA, Viral; D001613:beta 2-Microglobulin