Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors.
During lymphopoiesis, precursor cells negotiate a complex regulatory space, defined by the levels of several competing and cross-regulating transcription factors, before arriving at stable states of commitment to the B-, T- and NK-specific developmental programs. Recent perturbation experiments provide evidence that this space has three major axes, corresponding to the PU.1 versus GATA-1 balance, the intensity of Notch signaling through the CSL pathway, and the ratio of E-box transcription factors to their Id protein antagonists.
Warren
Luigi A
LA
Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA. luigiw@caltech.edu
Rothenberg
Ellen V
EV
D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D006410:Hematopoiesis / Q000276:immunology / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D008954:Models, Biological; D014157:Transcription Factors / Q000502:physiology*
D014157:Transcription Factors