Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics.
In this review, we summarize three sets of findings that have recently been observed in thalamic astrocytes and neurons, and discuss their significance for thalamocortical loop dynamics. (i) A physiologically relevant 'window' component of the low-voltage-activated, T-type Ca(2+) current (I(Twindow)) plays an essential part in the slow (less than 1 Hz) sleep oscillation in adult thalamocortical (TC) neurons, indicating that the expression of this fundamental sleep rhythm in these neurons is not a simple reflection of cortical network activity. It is also likely that I(Twindow) underlies one of the cellular mechanisms enabling TC neurons to produce burst firing in response to novel sensory stimuli. (ii) Both electrophysiological and dye-injection experiments support the existence of gap junction-mediated coupling among young and adult TC neurons. This finding indicates that electrical coupling-mediated synchronization might be implicated in the high and low frequency oscillatory activities expressed by this type of thalamic neuron. (iii) Spontaneous intracellular Ca(2+) ([Ca(2+)](i)) waves propagating among thalamic astrocytes are able to elicit large and long-lasting N-methyl-D-aspartate-mediated currents in TC neurons. The peculiar developmental profile within the first two postnatal weeks of these astrocytic [Ca(2+)](i) transients and the selective activation of these glutamate receptors point to a role for this astrocyte-to-neuron signalling mechanism in the topographic wiring of the thalamocortical loop. As some of these novel cellular and intracellular properties are not restricted to thalamic astrocytes and neurons, their significance may well apply to (patho)physiological functions of glial and neuronal elements in other brain areas.
Crunelli
Vincenzo
V
School of Biosciences, University of Cardiff, Museum Avenue, Cardiff CF10 3US, UK. crunelli@cardiff.ac.uk
Blethyn
Kate L
KL
Cope
David W
DW
Hughes
Stuart W
SW
Parri
H Rheinallt
HR
Turner
Jonathan P
JP
Tòth
Tibor I
TI
Williams
Stephen R
SR
D000200:Action Potentials; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D020747:Calcium Channels, T-Type / Q000502:physiology; D020013:Calcium Signaling; D002415:Cats; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004569:Electroencephalography; D008564:Membrane Potentials; D016202:N-Methylaspartate / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D012890:Sleep / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000502:physiology*
D020747:Calcium Channels, T-Type; D016202:N-Methylaspartate