Gene expression data preprocessing.
We present an interactive web tool for preprocessing microarray gene expression data. It analyses the data, suggests the most appropriate transformations and proceeds with them after user agreement. The normal preprocessing steps include scale transformations, management of missing values, replicate handling, flat pattern filtering and pattern standardization and they are required before performing any pattern analysis. The processed data set can be sent to other pattern analysis tools.
Herrero
J
J
Unidad de Bioinformática, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro, 3 28029 Madrid, Spain.
Díaz-Uriarte
R
R
Dopazo
J
J
D003628:Database Management Systems; D020869:Gene Expression Profiling / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface