title: [Lamotrigine in the treatment of pharmaco-resistant epilepsy in children].
abstract: Lamotrigine (LTG) is an antiepileptic drug whose therapeutic effect may be due to inhibition of the excitatory transmitter glutamate release. The aim of this study is to evaluate LTG efficacity and tolerability in the therapy of drug-resistant epilepsy in children. LTG is tested in 27 patients with different forms of epilepsy. Results show a satisfactory response and the low adverse effects of LTG in agreement with literature data. The therapy also improve cognitive function and relationship.
authors.affiliation: Facultatea de Medicină Clinica a III-a Pediatrie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Diaconu
authors.forename: D
authors.initials: D
authors.lastname: Moraru
authors.forename: Ioana
authors.initials: I
authors.lastname: Grigore
authors.forename: Mariana
authors.initials: M
authors.lastname: Frasin
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D003196:Computer Graphics; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine