Changes in intraocular pressure and pupil size following intramuscular administration of hydromorphone hydrochloride and acepromazine in clinically normal dogs.
OBJECTIVE
To investigate the effects of intramuscularly administered hydromorphone hydrochloride and acepromazine on intraocular pressure (IOP) and pupil size (PS).


METHODS
Seventeen dogs free of clinically relevant ocular abnormalities.


METHODS
Measurements of IOP and PS were obtained and the dogs were injected intramuscularly with hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg). Measurements of IOP and PS were repeated 10 min and 25 min later.


RESULTS
Though a decreasing trend in IOP values was demonstrated, no significant difference was noted in IOP from the initial examination to examination following intramuscular administration of hydromorphone and acepromazine. Significant miosis was present in 16 of 17 dogs at 10 min and 25 min following administration of hydromorphone and acepromazine.


CONCLUSIONS
Hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg) cause significant miosis in dogs at 10 and 25 min following intramuscular administration.
Stephan
Deborah D
DD
Indianapolis Veterinary Specialists, 8250 Bash Street, Indianapolis, IN 46250, USA. jstephan@sprynet.com
Vestre
W A
WA
Stiles
Jean
J
Krohne
Sheryl
S
D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001947:Breeding; D004285:Dogs / Q000502:physiology*; D005260:Female; D004091:Hydromorphone / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular / Q000662:veterinary; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008916:Miotics / Q000008:administration & dosage / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*; D012016:Reference Values
D000701:Analgesics, Opioid; D008916:Miotics; D000075:Acepromazine; D004091:Hydromorphone