title: Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives.
abstract: The alkylating properties of two artemisinin derivatives bearing a trifluoromethyl substituent at C10 were evaluated toward manganese(II) tetraphenylporphyrin, considered as a heme model. Chlorin-type covalent adducts were obtained by alkylation of the porphyrin ring by C-centered radicals derived from reductive activation of the peroxide function of the drugs.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, 31077 Toulouse Cedex 4, France.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Danièle
authors.initials: D
authors.lastname: Bonnet-Delpon
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Bégué
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
mesh_terms: D000478:Alkylation; D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins / Q000737:chemistry*; D006418:Heme / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010545:Peroxides / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D008665:Metalloporphyrins; D010545:Peroxides; D012717:Sesquiterpenes; C478042:manganese(II) tetraphenylporphyrin; D006418:Heme; C031327:artemisinin