title: Lead discovery of alpha,beta-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression.
abstract: alpha,beta-Unsaturated sulfones have been discovered from a combinatorial library as leads for a new series of inhibitors of inducible VCAM-1 expression. Although not essential, further conjugation of the sulfonyl group to another vinyl group or a phenyl group increases the potency dramatically.
authors.affiliation: AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, GA 30004, USA.
authors.forename: Liming
authors.initials: L
authors.lastname: Ni
authors.forename: X Sharon
authors.initials: XS
authors.lastname: Zheng
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Somers
authors.forename: Lee K
authors.initials: LK
authors.lastname: Hoong
authors.forename: Russell R
authors.initials: RR
authors.lastname: Hill
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Marino
authors.forename: Ki-Ling
authors.initials: KL
authors.lastname: Suen
authors.forename: Uday
authors.initials: U
authors.lastname: Saxena
authors.forename: Charles Q
authors.initials: CQ
authors.lastname: Meng
mesh_terms: D002478:Cells, Cultured; D020650:Combinatorial Chemistry Techniques; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis / Q000187:drug effects*
chemical_list: D013450:Sulfones; D019010:Vascular Cell Adhesion Molecule-1