title: [Bone marrow accumulation in gallium scintigraphy in patients with adult Still's disease].
abstract: We investigated the features and the usefulness of gallium scintigraphy in the diagnosis and the assessment of Adult Still's disease (ASD) by retrospective case review. Gallium scintigraphy have been done for 11 cases of ASD (3 males and 8 females) and 4 females were positive. Among these, 67 Ga-citrate was accumulated to the bone marrow in all 4 cases and to the major joints in 2 cases. Positive cases were rather serious and administered more immunosuppressants than negative cases. In order to characterize gallium scintigraphy findings of ASD, i.e. bone marrow accumulation, we analyzed 130 cases of collagen vascular diseases. Although 101 cases (77.7%) were positive, only 7 cases (5.4%) showed the accumulation of 67Ga-citrate to the bone marrow. These include 3 cases with ASD, and 1 case with systemic lupus erythematosus, polyarteritis nodosa, Wegener's granulomatosis and Sjögren's syndrome. We also accumulated 18 patients who exhibited bone marrow accumulation of 67Ga-citrate, and found that 7 patients had collagen vascular and their related diseases. In conclusion, bone marrow accumulation in gallium scintigraphy is a specific feature of collagen vascular diseases, especially ASD, and it is suggested that cases with positive gallium scintigraphy in ASD can be serious and resistant to treatment.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Saga-city.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Kanegae
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tada
authors.forename: Akihide
authors.initials: A
authors.lastname: Ohta
authors.forename: Osamu
authors.initials: O
authors.lastname: Ushiyama
authors.forename: Noriaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Syuichi
authors.initials: S
authors.lastname: Koarada
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Haruta
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yoshikai
authors.forename: Kohei
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002951:Citrates / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D005260:Female; D005708:Gallium / Q000493:pharmacokinetics; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D016706:Still's Disease, Adult-Onset
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D005708:Gallium; C103850:gallium citrate