Intravenous paraquat poisoning-induced multiple organ failure and fatality--a report of two cases.
Paraquat poisoning is the most common cause of fatal herbicide intoxication, mostly through oral ingestion. This work reports two cases of death following intravenous paraquat injection. The clinical courses of the two cases were fulminated and fatal. Toxic symptoms and severe organ function impairment developed soon after paraquat injection. Timely treatment with activated charcoal hemoperfusion with pulse steroid and cyclophosphamide was attempted in both cases; however, both cases died within five days owing to multiple organ failure. In cases of intravenous paraquat intoxication, toxic signs develop more quicker than with oral ingestion. The prognosis of intravenous paraquat intoxication is extremely poor.
Hsu
Hsiang-Hao
HH
Poison Center and Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
Chang
Chiz-Tzung
CT
Lin
Ja-Liang
JL
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006540:Herbicides / Q000008:administration & dosage / Q000506:poisoning*; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D010100:Oxygen / Q000097:blood; D010269:Paraquat / Q000008:administration & dosage / Q000506:poisoning*; D013405:Suicide
D000931:Antidotes; D006540:Herbicides; D002606:Charcoal; D010269:Paraquat; D010100:Oxygen