Contributions of proteome profiling to the molecular analysis of cancer.
The proteome is the most functional compartment encoded for in the genome. Technologies for protein separation and quantitation, coupled with mass spectrometry for protein identification, have provided the means for proteome profiling of tumor cell lines and tissues that complement genomic and transcriptomic profiling. The application of established and novel proteomic technologies to the molecular analysis of cancer is reviewed.
Wang
Hong
H
University of Michigan, Department of Pediatrics, 1150 W. Medical Center Drive, A520 MSRBI, Ann Arbor, MI 48109, USA.
Hanash
S M
SM
D015180:Electrophoresis, Gel, Two-Dimensional; D016678:Genome; D006801:Humans; D013058:Mass Spectrometry; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D020543:Proteome; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D020543:Proteome