title: Low incidence of community-acquired pneumonia among human immunodeficiency virus-infected patients after interruption of Pneumocystis carinii pneumonia prophylaxis.
abstract: We compared the incidence of bacterial pneumonia among 336 patients who discontinued trimethoprim-sulfamethoxazole (TMP-SMX) as prophylaxis against Pneumocystis carinii pneumonia (PCP) with that among 75 patients who fulfilled the criteria for discontinuation but continued receiving prophylaxis. The difference in the overall incidence rates for the 2 groups (1.2 events per 100 person-years) was not statistically significant. Discontinuation of TMP-SMX prophylaxis against PCP is not associated with a significant increase in the incidence of bacterial pneumonia among patients with a sustained CD4 cell count increase to >200 cells/microL.
authors.affiliation: Division of Infectious Diseases, University Hospital Berne, Switzerland.
authors.forename: Christina
authors.initials: C
authors.lastname: Eigenmann
authors.forename: Markus
authors.initials: M
authors.lastname: Flepp
authors.forename: Enos
authors.initials: E
authors.lastname: Bernasconi
authors.forename: Veronique
authors.initials: V
authors.lastname: Schiffer
authors.forename: Amalio
authors.initials: A
authors.lastname: Telenti
authors.forename: Heiner
authors.initials: H
authors.lastname: Bucher
authors.forename: Thomas
authors.initials: T
authors.lastname: Wagels
authors.forename: Martin
authors.initials: M
authors.lastname: Egger
authors.forename: Hansjakob
authors.initials: H
authors.lastname: Furrer
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D018890:Chemoprevention; D017714:Community-Acquired Infections / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*