Interferon-gamma reduces interleukin-4- and interleukin-13-augmented transforming growth factor-beta2 production in human bronchial epithelial cells by targeting Smads.
Wen
Fu-Qiang
FQ
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198-5125, USA.
Liu
Xiangde D
XD
Terasaki
Yusuke
Y
Fang
Qiuhong H
QH
Kobayashi
Tetsu
T
Abe
Shinji
S
Rennard
Stephen I
SI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000187:drug effects*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000032:analysis*; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D018793:Interleukin-13 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D051785:Smad Proteins; D015534:Trans-Activators / Q000187:drug effects*; D016212:Transforming Growth Factor beta / Q000032:analysis*; D053781:Transforming Growth Factor beta2
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D004268:DNA-Binding Proteins; D007166:Immunosuppressive Agents; D018793:Interleukin-13; D051785:Smad Proteins; C509041:TGFB2 protein, human; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2; D015847:Interleukin-4; D007371:Interferon-gamma