title: Significant linkage of Parkinson disease to chromosome 2q36-37.
abstract: Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Pankratz
authors.forename: William C
authors.initials: WC
authors.lastname: Nichols
authors.forename: Sean K
authors.initials: SK
authors.lastname: Uniacke
authors.forename: Cheryl
authors.initials: C
authors.lastname: Halter
authors.forename: Alice
authors.initials: A
authors.lastname: Rudolph
authors.forename: Cliff
authors.initials: C
authors.lastname: Shults
authors.forename: P Michael
authors.initials: PM
authors.lastname: Conneally
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005190:Family; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008025:Ligases / Q000235:genetics; D008126:Lod Score; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases
chemical_list: D005819:Genetic Markers; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases