Arylamine N-acetyltransferase-2 genotypes in the Thai population.
OBJECTIVE
To determine the frequencies of the major arylamine- N-acetyltransferase-2 (NAT2) alleles in the Thai population.


METHODS
DNA samples from 235 Thai individuals were analysed by polymerase chain reaction with restriction fragment length polymorphism assays.


RESULTS
The frequency distribution of major NAT2 alleles, including NAT2*4, NAT2*5, NAT2*6 and NAT2*7 were 0.381 (95% CI 0.337, 0.426), 0.038 (0.023, 0.060), 0.326 (0.283, 0.370) and 0.204 (0.169, 0.244), respectively. When converted to phenotypes, the study population comprised 63.8% rapid acetylators and 36.2% slow acetylators.


CONCLUSIONS
The pattern of NAT2 alleles of Thais is similar to those of many Asian populations, although the frequency of NAT2*4 is significantly lower and NAT2*7 is higher than that of Oriental populations.
Kukongviriyapan
Veerapol
V
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Thailand, 40002. veerapol@kku.ac.th
Prawan
Auemduan
A
Tassaneyakul
Wichittra
W
Aiemsa-Ard
Jareerat
J
Warasiha
Benjamart
B
D000107:Acetylation; D000328:Adult; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D013785:Thailand / Q000208:ethnology
D001191:Arylamine N-Acetyltransferase