Phylogeography of infectious haematopoietic necrosis virus in North America.
Infectious hematopoietic necrosis virus (IHNV) is a rhabdoviral pathogen that infects wild and cultured salmonid fish throughout the Pacific Northwest of North America. IHNV causes severe epidemics in young fish and can cause disease or occur asymptomatically in adults. In a broad survey of 323 IHNV field isolates, sequence analysis of a 303 nucleotide variable region within the glycoprotein gene revealed a maximum nucleotide diversity of 8.6 %, indicating low genetic diversity overall for this virus. Phylogenetic analysis revealed three major virus genogroups, designated U, M and L, which varied in topography and geographical range. Intragenogroup genetic diversity measures indicated that the M genogroup had three- to fourfold more diversity than the other genogroups and suggested relatively rapid evolution of the M genogroup and stasis within the U genogroup. We speculate that factors influencing IHNV evolution may have included ocean migration ranges of their salmonid host populations and anthropogenic effects associated with fish culture.
Kurath
Gael
G
Western Fisheries Research Center, USGS Biological Resources Division, 6505 NE 65th Street, Seattle, WA 98115, USA.
Garver
Kyle A
KA
University of Washington, Department of Pathobiology, Seattle, WA 98195, USA.|Western Fisheries Research Center, USGS Biological Resources Division, 6505 NE 65th Street, Seattle, WA 98115, USA.
Troyer
Ryan M
RM
University of Washington, Department of Pathobiology, Seattle, WA 98195, USA.|Western Fisheries Research Center, USGS Biological Resources Division, 6505 NE 65th Street, Seattle, WA 98115, USA.
Emmenegger
Eveline J
EJ
Western Fisheries Research Center, USGS Biological Resources Division, 6505 NE 65th Street, Seattle, WA 98115, USA.
Einer-Jensen
Katja
K
Danish Veterinary Laboratory, Hangovej 2, 8200 Aarhus N, Denmark.
Anderson
Eric D
ED
Western Fisheries Research Center, USGS Biological Resources Division, 6505 NE 65th Street, Seattle, WA 98115, USA.
D000818:Animals; D002170:Canada; D005393:Fish Diseases / Q000821:virology*; D005398:Fisheries; D005399:Fishes; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics; D029142:Infectious hematopoietic necrosis virus / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D015205:Northwestern United States; D010802:Phylogeny; D018353:Rhabdoviridae Infections / Q000662:veterinary* / Q000821:virology; D012487:Salmonidae / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
D006023:Glycoproteins; D014764:Viral Proteins