[Non-penetrating trabecular surgery with application of mitomycin C].
OBJECTIVE
To evaluate the clinical effect of non-penetrating trabecular surgery (NPTS) with mitomycin C (MMC) in primary open-angle glaucoma (POAG).


METHODS
Twenty-five eyes of 18 patients with POAG underwent NPTS with MMC during the operation. The mean follow-up was 16.6 months (6 - 28 months).


RESULTS
The mean preoperative intraocular pressure (IOP) was (27.93 +/- 7.62) mm Hg (1 mm Hg = 0.133 kPa) which decreased to a mean postoperative IOP of (14.62 +/- 3.53) mm Hg (P < 0.001). After operation, there was an obvious diffuse bleb in each eye, in the 3 months after operation, there were functional blebs in 21 eyes, and the successful filtration was ceased in 4 eyes. The anterior chamber reaction was mild. Hyphema occurred in 1 eye after operation. Intra-operatively, in 4 eyes microperforations occurred in the trabecular meshwork without iris prolapse, and after operation, under the gonioscope, the perforation could be observed in these eyes. In another 2 eyes, there was no intra-operative perforation, but a small fissure was seen by gonioscopy.


CONCLUSIONS
NPTS with application of MMC can lower the IOP effectively in this group of patients. The recovery of vision after operation is quick. A few complications occurred after operation. It is a promising technique to treat POAG.
Yang
Shaowu
S
Department of Ophthalmology, The Second Hospital of Ningxia, Guyuan, Ningxia 756000, China. zhm1235@sina.com
Li
Yun
Y
Ma
Xiang
X
Li
Yusen
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000494:pharmacology; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity
D016685:Mitomycin