title: Pericardiocentesis and pancreatic aspiration needle biopsy in coagulopathic and thrombocytopenic cirrhotic patient.
abstract: We report on the case of a 40-year-old patient with coagulopathic alcoholic cirrhosis who underwent ultrasound-directed pericardiocentesis and fine-needle aspiration biopsy of the pancreas after receiving recombinant human factor VIIa (rhFVIIa). The infusion of rhFVIIa rapidly corrected her coagulopathy and made it possible to perform both procedures. The marked changes produced in the prothrombin time and international normalized ratio as a result of the infusion of rhFVIIa are presented. As a result of these changes in coagulation status, both procedures were performed safely, and the patient's clinical management and subsequent care plan were defined.
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL 60153, USA.
authors.forename: Ayse L
authors.initials: AL
authors.lastname: Mindikoglu
authors.forename: Abhinandana
authors.initials: A
authors.lastname: Anantharaju
authors.forename: Jaime
authors.initials: J
authors.lastname: Villanueva
authors.forename: Nikunj
authors.initials: N
authors.lastname: Shah
authors.forename: David H
authors.initials: DH
authors.lastname: Van Thiel
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D010190:Pancreatic Neoplasms / Q000473:pathology; D020519:Pericardiocentesis / Q000379:methods*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa