title: Effects of pyrroline and pyrrolidine nitroxides on lipid peroxidation in heart tissue of rats treated with doxorubicin.
abstract: Protection from doxorubicin-induced lipid peroxidation in vivo by two pyrroline and pyrrolidine nitroxides, Pirolin, PL, and Pirolid, PD, was examined in the heart tissue of rats treated with this drug. The level of lipid peroxidation was estimated on the basis of MDA content. A considerable (three-fold) increase in the MDA amount was found in heart homogenates from rats injected with doxorubicin, whereas no significant changes in MDA content compared to control were observed in cardiomyocytes treated with the nitroxides (Pirolin or Pirolid) only. Pirolin injected simultaneously with doxorubicin showed antioxidative effect and markedly attenuated lipid peroxidation in the heart tissue caused by this drug. In contrast to Pirolin, structurally related Pirolid was ineffective in the protection of heart myocytes from DOX-induced lipid peroxidation.
authors.affiliation: Department of Thermobiology, University of Łódź, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Koceva-Chyła
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Gwoździński
authors.forename: Agata
authors.initials: A
authors.lastname: Kochman
authors.forename: Aneta
authors.initials: A
authors.lastname: Stolarska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Jóźwiak
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors / Q000633:toxicity; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009589:Nitrogen Oxides / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000903:Antibiotics, Antineoplastic; D009589:Nitrogen Oxides; D011758:Pyrroles; D011759:Pyrrolidines; C013231:pyrroline; D008315:Malondialdehyde; D004317:Doxorubicin; C032519:pyrrolidine