title: Trans-dentinal stimulation of tertiary dentinogenesis.
abstract: Trans-dentinal stimulation of tertiary dentinogenesis has long been recognized, and has traditionally been ascribed to diffusion of irritant substances arising during injury and restorative treatment. Identification of bio-active components, especially growth factors including TGF-beta s, sequestered within dentin matrix provides a new explanation for cellular signaling during tertiary dentinogenesis. Both isolated dentin matrix components and pure growth factors (TGF-beta s) have been shown to signal cellular events leading to reactionary and reparative tertiary dentinogenesis. Release of these bio-active components from dentin matrix may arise during carious attack and other injury to the tissue, and also during subsequent surgical intervention and restoration of the tooth. Both cavity-conditioning agents and leaching from restorative materials may contribute to release of these components. Distance of diffusion, as determined by cavity residual dentin thickness, and other restorative parameters may influence the signaling process after release of these components. Careful consideration of the interplay between tissue injury and surgical and restorative material factors is required for optimum exploitation of the exquisite regenerative capacity of dentin-pulp for more biological approaches to clinical treatment of dental disease.
authors.affiliation: School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK. a.j.smith@bham.ac.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Smith
authors.forename: P E
authors.initials: PE
authors.lastname: Murray
authors.forename: A J
authors.initials: AJ
authors.lastname: Sloan
authors.forename: J B
authors.initials: JB
authors.lastname: Matthews
authors.forename: S
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000818:Animals; D003731:Dental Caries / Q000503:physiopathology; D003736:Dental Cavity Lining / Q000009:adverse effects; D003764:Dental Materials / Q000009:adverse effects; D003782:Dental Pulp / Q000502:physiology; D003793:Dental Restoration, Permanent / Q000009:adverse effects; D003804:Dentin / Q000502:physiology* / Q000648:ultrastructure; D003809:Dentin, Secondary / Q000502:physiology* / Q000648:ultrastructure; D003810:Dentinogenesis / Q000502:physiology; D004058:Diffusion; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D009804:Odontoblasts / Q000502:physiology; D012038:Regeneration; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D003764:Dental Materials; D006133:Growth Substances; D007509:Irritants; D016212:Transforming Growth Factor beta