title: Photochemical protection of amines with Cbz and Fmoc groups.
abstract: The photochemical conversion of amines into carbamates was achieved using N-Cbz-, N-Fmoc-, and N-Boc-5,7-dinitroindolines. This reaction allows the protection of amines in neutral medium. Primary and unhindered secondary amines were protected to yield their benzyloxycarbonyl- and 9-fluorenylmethoxycarbonyl derivatives efficiently, whereas bulky amines or anilines gave low yields or no product. On the other hand, the formation of N-Boc compounds, although possible, proceeded only with low yields.
authors.affiliation: Department of Chemistry, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
authors.forename: Céline
authors.initials: C
authors.lastname: Helgen
authors.forename: Christian G
authors.initials: CG
authors.lastname: Bochet