title: Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.
abstract: We present the 4.8-Mb complete genome sequence of Salmonella enterica serovar Typhi strain Ty2, a human-specific pathogen causing typhoid fever. A comparison with the genome sequence of recently isolated S. enterica serovar Typhi strain CT18 showed that 29 of the 4,646 predicted genes in Ty2 are unique to this strain, while 84 genes are unique to CT18. Both genomes contain more than 200 pseudogenes; 9 of these genes in CT18 are intact in Ty2, while 11 intact CT18 genes are pseudogenes in Ty2. A half-genome interreplichore inversion in Ty2 relative to CT18 was confirmed. The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics.
authors.affiliation: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Deng
authors.forename: Shian-Ren
authors.initials: SR
authors.lastname: Liou
authors.forename: Guy
authors.initials: G
authors.lastname: Plunkett
authors.forename: George F
authors.initials: GF
authors.lastname: Mayhew
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Rose
authors.forename: Valerie
authors.initials: V
authors.lastname: Burland
authors.forename: Voula
authors.initials: V
authors.lastname: Kodoyianni
authors.forename: David C
authors.initials: DC
authors.lastname: Schwartz
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Blattner
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002876:Chromosomes, Bacterial; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D023281:Genomics; D008969:Molecular Sequence Data; D051719:MutS DNA Mismatch-Binding Protein; D050901:Nitrate Reductase; D009565:Nitrate Reductases / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D039002:Prophages / Q000235:genetics; D011544:Pseudogenes; D012485:Salmonella typhi / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012808:Sigma Factor / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D009565:Nitrate Reductases; D050901:Nitrate Reductase; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein; C497175:MutS protein, E coli