title: Early invasive cervical adenocarcinoma: its potential for nodal metastasis or recurrence.
abstract: OBJECTIVE
  To investigate the potential for nodal spread or recurrence in patients with early invasive cervical adenocarcinoma. The possible application of the International Federation of Gynecology and Obstetrics (FIGO) classification (1994) to this variant was also examined.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  Gynaecological oncology division of Cancer Institute Hospital, Japan.
  
  
  METHODS
  302 patients with FIGO Stage 0-IIB cervical adenocarcinoma treated surgically at the Cancer Institute Hospital.
  
  
  METHODS
  Clinicopathological analysis was performed on 47 patients with early invasive cervical adenocarcinoma in whom the depth of stromal invasion was 5 mm or less. All patients underwent radical hysterectomy and pelvic lymphadenectomy.
  
  
  RESULTS
  In 30 patients with a depth of tumour invasion of 3 mm or less, no lymph node metastasis was found, while two patients developed recurrence; one had a depth of invasion of 3 mm and a horizontal tumour spread of 3 mm, and the other had horizontal spread of more than 7 mm. In 17 patients with a depth of invasion from 3 to 5 mm, there was also no lymph node metastasis, but two patients developed recurrence; one had horizontal tumour spread of 7 mm or less, and the other had horizontal spread of more than 7 mm.
  
  
  CONCLUSIONS
  Early invasive cervical adenocarcinoma with a depth of invasion of 3 mm or less and a horizontal spread of 7 mm or less has little potential for nodal metastasis or recurrence. It seems possible that the FIGO definition (1994) of early cervical cancer may be applicable in its present form to early cervical adenocarcinoma.
authors.affiliation: Department of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 1-37-1, Kami-Ikebukuro, Toshima-ku, 170, Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirai
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Takeshima
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tate
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.forename: Reiko
authors.initials: R
authors.lastname: Furuta
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hasumi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*