Voluntary discontinuance of seven years successful insulin prophylaxis produced shortly overt diabetes in a first-degree relative of a diabetic child at high risk for type 1 diabetes.
This is the story of a nondiabetic first-degree relative of a child with Type 1 Diabetes who was screened for Type 1 diabetes and was found to be at high risk being positive for genetic, immunologic and metabolic markers. He accepted to be treated with low-dose subcutaneous insulin and for 7 years he has been living in subclinical prediabetes state. At the beginning of eighth year, he voluntary discontinued the preventive insulin therapy and after 18 months clinically overt diabetes appeared.
Vanelli
Maurizio
M
Department of Pediatrics, Chair of Pediatrics, Regional Centre for Children and Adolescents with Diabetes, University of Parma, Parma, Italy. vanelli@unipr.it
Chiari
Giovanni
G
Giacalone
Tommaso
T
Adinolfi
Barbara
B
Ndongko
Angomeh
A
Casadei
Annachiara
A
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D013997:Time Factors
D007004:Hypoglycemic Agents; D007328:Insulin