[Telomerase].
Telomerase, an intranuclear enzyme, binds to telomeres at chromosome ends, helps to elongate telomere length and is closely linked to attainment of cellular immortality, a step in carcinogenesis. Since telomerase activity has been detected in several human tumors and hematopoietic malignancies, this enzyme is thought to be a useful marker for cancer diagnosis. Among the components of telomerase, human telomerase catalytic subunit(hTERT) is the most important regulatory factor for telomerase activity. Therefore, quantitation of hTERT mRNA expression may be a new approach to measuring telomerase activity.
Tsuji
Naoki
N
Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine.
Watanabe
Naoki
N
D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D012333:RNA, Messenger / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000032:analysis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D034501:Telomere-Binding Proteins
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D034501:Telomere-Binding Proteins; D019098:Telomerase