SET-ting the stage for life and death.
Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
Chakravarti
Debabrata
D
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Hong
Rui
R
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D053804:Granzymes; D024261:HMGB2 Protein / Q000378:metabolism; D056488:Histone Chaperones; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D054778:NM23 Nucleoside Diphosphate Kinases; D009687:Nuclear Proteins / Q000378:metabolism; D009701:Nucleoside-Diphosphate Kinase; D010750:Phosphoproteins / Q000378:metabolism; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D024261:HMGB2 Protein; D056488:Histone Chaperones; D054778:NM23 Nucleoside Diphosphate Kinases; D009687:Nuclear Proteins; D010750:Phosphoproteins; C513473:SET protein, human; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human; D020559:Monomeric GTP-Binding Proteins