NADPH-diaphorase-positive neurons in the auditory cortex of young and old rats.
Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young animals, as well as changes in the shape and configuration of nerve cell bodies and dendrites. Quantitative analysis demonstrated an age-related increase in the number of dendritic segments and dendritic branching points. The length of dendrites in NADPH-d-positive neurons and their density increased in very old rats. The total number of NADPH-d-positive neurons within the Te 1 and Te 3 fields was 13% lower in the old rats than in the young.
Ouda
L
L
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague.
Nwabueze-Ogbo
F C
FC
Druga
R
R
Syka
J
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000201:enzymology* / Q000473:pathology; D002452:Cell Count; D003712:Dendrites / Q000648:ultrastructure; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D020318:Rats, Long-Evans; D014018:Tissue Distribution
D009252:NADPH Dehydrogenase