Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence.
OBJECTIVE
In a modified case-control association study we tested the assumption that two polymorphisms (A(118)G in exon 1 and IVS2+31 in intron 2) of the human mu-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence.


METHODS
In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany.


RESULTS
For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. CONCLUSIONS ;Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals.
Franke
Petra
P
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. petra.franke@ukb.uni-bonn.de
Wendel
Birgit
B
Knapp
Michael
M
Schwab
Sibylle G
SG
Neef
Daniela
D
Maier
Wolfgang
W
Wildenauer
Dieter B
DB
Hoehe
Margret R
MR
D000328:Adult; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000235:genetics*; D018579:Patient Selection; D011110:Polymorphism, Genetic; D011329:Prisoners; D017450:Receptors, Opioid, mu / Q000235:genetics*
D017450:Receptors, Opioid, mu