title: Diffuse uterine adenomatoid tumor in an immunosuppressed renal transplant recipient.
abstract: A case of diffuse adenomatoid tumor of the uterus in an immunosuppressed renal transplant recipient is reported and compared with two previously reported, similar cases. The multinodular uterine lesion grossly resembled intramural leiomyomata except for a mucoid cut surface and a cystic serosal component. The predominant patterns of the tumor were adenoid and angiomatoid with less prominent solid and cystic patterns. Immunohistochemical and ultrastructural studies confirmed the mesothelial nature of the tumor cells. Additionally, there was strong diffuse immunoreactivity for proliferating cell nuclear antigen, a low expression of Ki-67, and weak nuclear p53 staining. The relationship between immunosuppression and diffuse adenomatoid tumors is discussed.
authors.affiliation: Department of Pathology, National University Hospital, Singapore, Republic of Singapore.
authors.forename: Chee Leong
authors.initials: CL
authors.lastname: Cheng
authors.forename: Aileen
authors.initials: A
authors.lastname: Wee
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D018254:Adenomatoid Tumor / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology; D008854:Microscopy, Electron; D014594:Uterine Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure