Involvement of the raphé pallidus in the suppressive effect of preoptic warming on non-shivering thermogenesis in rats.
Thermogenesis in the brown adipose tissue (BAT) is activated by the stimulation of the ventromedial hypothalamic nucleus (VMH). Local warming of the preoptic area (PO) suppresses this response. Injection of the GABA(A) receptor antagonist bicuculline into the caudal periaqueductal gray (cPAG), where excitatory neurons for BAT thermogenesis are located, did not influence the suppressive effect of PO warming. On the other hand, after bicuculline injection into the raphé pallidus, where excitatory neurons for BAT thermogenesis are also located, VMH stimulation produced BAT thermogenesis even during PO warming. The present results suggest that the inhibitory signal from the PO reaches the raphé pallidus and not the cPAG for the control of BAT thermogenesis.
Taniguchi
Aki
A
Department of Physiology, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan.
Chen
Xiao Ming
XM
Nagashima
Kei
K
Tanaka
Mutsumi
M
Kanosue
Kazuyuki
K
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012768:Shivering / Q000187:drug effects / Q000502:physiology; D022722:Thermogenesis / Q000187:drug effects / Q000502:physiology*; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*
D001640:Bicuculline