title: Multiple organ failure and outcome of critically ill patients with haematological malignancy.
abstract: BACKGROUND
  The number of failing organs systems in ICU patients with haematological malignancy is associated with outcome. The objective of this study was to assess short and long-term survival in these patients with special reference to multiple organ failure reflected by the SOFA (Sequential Organ Failure Assessment) score.
  
  
  METHODS
  Retrospective chart review of haematological patients admitted to the 10-bed intensive care unit (ICU) of a tertiary level academic teaching hospital from 1994 to 1998. Of 31 admitted patients with the diagnosis of haematological malignancy, the charts of 30 were available for analysis.
  
  
  RESULTS
  Univariate logistic regression analysis of factors previously shown to influence survival revealed that only admission SOFA score and untreated status of haematological disease were significantly associated with survival (P < 0.05). ICU, 3-month and one-year survival rates were 57% (17/30), 23% (7/30) and 20% (6/30), respectively. If maximal SOFA score during the ICU stay was included in a multivariate model comprising treatment status and effect, admission day SOFA and APACHE II scores, mechanical ventilation, renal replacement therapy and neutropenia, the maximal SOFA score became the only independent variable. All patients with an admission SOFA score exceeding 11 died in hospital. Leave-one-out method revealed that admission SOFA scores and the status of haematological disease (untreated or not) correctly classified 83% (25 of 30) of patients to survivors or non-survivors.
  
  
  CONCLUSIONS
  Multiple organ failure assessed as SOFA score on admission and status of disease were associated with outcome in critically ill patients with haematological malignancy.
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Meilahti Hospital, Helsinki, Finland. tom.silfvast@hus.fi
authors.forename: T
authors.initials: T
authors.lastname: Silfvast
authors.forename: V
authors.initials: V
authors.lastname: Pettilä
authors.forename: A
authors.initials: A
authors.lastname: Ihalainen
authors.forename: E
authors.initials: E
authors.lastname: Elonen
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D016638:Critical Illness; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology* / Q000503:physiopathology; D015999:Multivariate Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome