title: Treatment of delirium in older adults with quetiapine.
abstract: Delirium is a neuropsychiatric syndrome characterized by impairment of consciousness, changes in cognition, or perceptual disturbances. In addition, delirium is often accompanied by delusions, hallucinations, and agitation. In this study, 12 older patients with delirium were treated for neuropsychiatric symptoms with quetiapine. The mean duration for stabilization was 5.91 +/- 2.22 days, and the mean dose was 93.75 +/- 23.31 mg/day. None of the 12 patients developed extrapyramidal symptoms. There were significant improvements on all measures used in this study. Interestingly, the Delirium Rating Scale scores along with scores of the Mini-Mental State Examination and Clock Drawing Test continued to improve throughout the 3-month study period. In our study, we found that quetiapine was a safe and effective treatment in hospitalized older patients with delirium.
authors.affiliation: Salem Veterans Affairs Medical Center, Department of Psychiatric Medicine, School of Medicine, University of Virginia, 24153, USA. kye.kim@med.va.gov
authors.forename: Kye Y
authors.initials: KY
authors.lastname: Kim
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Bader
authors.forename: Victor
authors.initials: V
authors.lastname: Kotlyar
authors.forename: Debra
authors.initials: D
authors.lastname: Gropper
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003693:Delirium / Q000188:drug therapy*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate