Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22).
We report a t(6;8)(q15;q22) in a patient with myelodysplastic syndrome (MDS) with erythroid hypoplasia. The patient was successfully treated with an immunosuppressive treatment with cyclosporin A, while the translocation was repeatedly detected as the sole anomaly with the percentages of positive cells ranging from 5% to 70%. To our knowledge, the t(6:8) has never been described in MDS.
Takata
Shiro
S
Department of Medicine II, Okayama University Medical School, Okayama 700-8558, Japan.
Kojima
Kensuke
K
Fujii
Nobuharu
N
Kaneda
Kinuyo
K
Yoshida
Chikamasa
C
Hashimoto
Daigo
D
Asakura
Shoji
S
Shinagawa
Katsuji
K
Tanimoto
Mitsune
M
D000368:Aged; D000753:Anemia, Refractory / Q000188:drug therapy* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D020223:Chromosome Painting; D002896:Chromosomes, Human, Pair 6 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D016572:Cyclosporine / Q000627:therapeutic use*; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D014178:Translocation, Genetic
D007166:Immunosuppressive Agents; D016572:Cyclosporine