Vasorelaxing properties and bio-guided fractionation of Cedrelopsis grevei.
The activity-guided fractionation of the hydroalcoholic extract of trunk bark of Cedrelopsis grevei led to the isolation of five coumarins, norbraylin (1), methyl-O-cedrelopsin (2), cedrecoumarin A (3), scoparone (4) and braylin (5) as a part of the constituents responsible for the vasorelaxing activity observed for the crude extract.
Rakotoarison
Olivier
O
Rabenau
Ingeborg
I
Lobstein
Annelise
A
Um
Byung-Hun
BH
Schott
Christa
C
Anton
Robert
R
Randriantsoa
Adolphe
A
Andriantsitohaina
Ramaoson
R
D000818:Animals; D001011:Aorta / Q000187:drug effects; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D029582:Meliaceae; D009638:Norepinephrine; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D003374:Coumarins; D010936:Plant Extracts; D014665:Vasodilator Agents; D009638:Norepinephrine