The active caspase-8 heterotetramer is formed at the CD95 DISC.
Lavrik
I
I
Krueger
A
A
Schmitz
I
I
Baumann
S
S
Weyd
H
H
Krammer
P H
PH
Kirchhoff
S
S
D000906:Antibodies; D017209:Apoptosis / Q000502:physiology*; D001402:B-Lymphocytes / Q000201:enzymology*; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004792:Enzyme Precursors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D021122:Protein Subunits / Q000276:immunology / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014407:Tumor Cells, Cultured; D019014:fas Receptor / Q000378:metabolism*
D000906:Antibodies; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004791:Enzyme Inhibitors; D004792:Enzyme Precursors; D046911:Macromolecular Substances; D021122:Protein Subunits; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; C505407:CASP3 protein, human; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases