[The blood level of nitric oxide metabolites in experimental autoimmune disease during immunosuppressive therapy].
Experimental autoimmune disease causes a drastic increase in the production of nitric oxide metabolites. The latter correlate with the indices of autoimmunity expression, with the levels of cyclic nucleotides, with the severity of morphological impairment of the structures of immunocompetent organs. The use of immunosuppressive agents in the pathogenetic therapy of an autoimmune process normalizes both the blood levels of nitrites/nitrates and immunological parameters; this reflects a clear-cut relationship between the synthesis of nitric oxide and the immune response of the body.
Zviagina
T V
TV
Siniachenko
O V
OV
Grin'
V K
VK
D'iakov
I N
IN
Nikolenko
Iu I
IuI
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004247:DNA / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D007166:Immunosuppressive Agents; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP