Selenium deficiency in a patient with Crohn's disease receiving long-term total parenteral nutrition.
We report a case of selenium deficiency in a patient with Crohn's disease on long-term total parenteral nutrition (TPN). She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis. Since her plasma selenium level was found to be below the measurable level, we diagnosed this case as selenium deficiency. After intravenous administration of sodium selenite, her symptoms were reversed. Careful attention should be paid to selenium deficiency when a patient receives long-term TPN; supplementary administration of selenium via TPN may be required because selenium is often not routinely added to TPN formulations.
Ishida
Tetsuya
T
Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita.
Himeno
Katsuro
K
Torigoe
Yasuko
Y
Inoue
Megumi
M
Wakisaka
Osamu
O
Tabuki
Takuo
T
Ono
Hidenobu
H
Honda
Koichi
K
Mori
Tetsu
T
Seike
Masataka
M
Yoshimatsu
Hironobu
H
Sakata
Toshiie
T
D000328:Adult; D003082:Colectomy / Q000009:adverse effects / Q000379:methods; D003424:Crohn Disease / Q000175:diagnosis* / Q000601:surgery; D003677:Deficiency Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D010288:Parenteral Nutrition / Q000009:adverse effects* / Q000379:methods; D012086:Reoperation; D018570:Risk Assessment; D012643:Selenium / Q000172:deficiency*; D012720:Severity of Illness Index; D012778:Short Bowel Syndrome / Q000209:etiology / Q000628:therapy*; D018038:Sodium Selenite / Q000627:therapeutic use*; D016896:Treatment Outcome
D012643:Selenium; D018038:Sodium Selenite