Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.
Zwijnenburg
Petra J G
PJ
Department of Pediatrics, Vrije Universiteit Medical Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl
van der Poll
Tom
T
Florquin
Sandrine
S
Roord
John J
JJ
van Furth
A Marceline
AM
D000818:Animals; D001769:Blood / Q000382:microbiology; D001921:Brain / Q000276:immunology / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D018925:Chemokines / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005786:Gene Expression Regulation; D016753:Interleukin-10 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D008586:Meningitis, Pneumococcal / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity*
D018925:Chemokines; D016207:Cytokines; D016753:Interleukin-10