title: Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment.
abstract: We report a case of a 76-year-old-man who developed spontaneous hemarthrosis of his right knee following clopidogrel-aspirin treatment. Clopidogrel is an ADP receptor antagonist and in combination with aspirin widely used in patients with atherosclerotic vascular disease to reduce the incidence of ischemic events. To date, no case of spontaneous hemarthrosis following clopidogrel-aspirin therapy has been reported. Prompt aspiration after discontinuing the ADP receptor antagonist-aspirin combination therapy can assist early diagnosis and may prevent further damage to the joint. In conclusion, spontaneous hemarthrosis is a possible complication following clopidogrel-aspirin therapy and is recommended to be evaluated when appropriate clinical symptoms (e.g., intraarticular effusion) present.
authors.affiliation: Department of Orthopaedics, University Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. justus_gille@usa.net
authors.forename: J
authors.initials: J
authors.lastname: Gille
authors.forename: J
authors.initials: J
authors.lastname: Bernotat
authors.forename: S
authors.initials: S
authors.lastname: Böhm
authors.forename: P
authors.initials: P
authors.lastname: Behrens
authors.forename: J F
authors.initials: JF
authors.lastname: Löhr
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001780:Blood Coagulation Tests; D000077144:Clopidogrel; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006395:Hemarthrosis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D020370:Osteoarthritis, Knee / Q000175:diagnosis; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D058919:Purinergic P2 Receptor Antagonists; D012307:Risk Factors; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors; D058919:Purinergic P2 Receptor Antagonists; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin