Synthesis of functionalized piperidinones.
A versatile, stereoselective synthesis of 5-hydroxypiperidinones with substituents at N1, C3, and C6 has been developed. The sequence involves ring-closing metathesis of a diene amide and epoxidation of the resulting alkene, followed by base-mediated elimination, and finally hydrogenation.
Humphries
Mark E
ME
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Murphy
James
J
Phillips
Andrew J
AJ
Abell
Andrew D
AD