Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain.
The Ca(2+)/calmodulin-dependent protein kinase kinases alpha and beta (CaMKKs alpha and beta) are novel members of the CaM kinase family. The CaMKKbeta was cloned from mouse brain. The deduced amino acid sequence shared 96.43% homology with the rat CaMKKbeta. Both the alpha and beta isoforms were widely distributed throughout the adult mouse brain. Additionally, all peripheral tissues examined displayed CaMKK alpha and beta expression.
Vinet
Jonathan
J
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy.
Carra
Serena
S
Blom
Joan M C
JM
Harvey
Mario
M
Brunello
Nicoletta
N
Barden
Nicholas
N
Tascedda
Fabio
F
D000818:Animals; D001921:Brain / Q000201:enzymology*; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase; D018076:DNA, Complementary / Q000032:analysis / Q000235:genetics; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009474:Neurons / Q000201:enzymology*; D020033:Protein Isoforms / Q000235:genetics / Q000302:isolation & purification; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000302:isolation & purification*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D018076:DNA, Complementary; D020033:Protein Isoforms; D012333:RNA, Messenger; D017346:Protein Serine-Threonine Kinases; C517698:CAMKK2 protein, human; D054737:Calcium-Calmodulin-Dependent Protein Kinase Kinase; C517700:Camkk2 protein, mouse; C517702:Camkk2 protein, rat