[Effect of dietary intoxication by mercury salts on cysteine proteinase activity in rat tissues].
The experiments on dietary intoxication of rats by HgI2 or Hg(NO3)2 show that the activities of lysosomal proteinase cathepsin B and cytosolic Ca(2+)-activated proteinases (calpains I and II) in the liver and kidney depend on the mercury salt solubility and the exposure duration. Mercury iodide and nitrate contribute more to inhibiting cathepsin B and calpains activities in the above tissues, respectively.
Bondareva
L A
LA
Institute of Biology, Karelian Scientific Center, Russian Academy of Science, ul. Pushkinskaya 11, Petrozavodsk, 185610 Russia. bondareva@bio.krc.karelia.ru
Nemova
N N
NN
Kiaĭviariaĭnen
E I
EI
Krupnova
M Iu
MIu
Ostashkova
V V
VV
D000284:Administration, Oral; D000818:Animals; D002154:Calpain / Q000187:drug effects / Q000378:metabolism; D002401:Cathepsin B / Q000187:drug effects / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000187:drug effects* / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004032:Diet; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000633:toxicity; D005260:Female; D007454:Iodides / Q000737:chemistry / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism; D017669:Mercury Compounds / Q000737:chemistry / Q000633:toxicity*; D009566:Nitrates / Q000737:chemistry / Q000633:toxicity; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012492:Salts / Q000633:toxicity; D012995:Solubility
D004791:Enzyme Inhibitors; D007454:Iodides; D017669:Mercury Compounds; D009566:Nitrates; D011506:Proteins; D012492:Salts; C029948:mercury nitrate; D002154:Calpain; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C025718:mercuric iodide, red