title: Effects of Bauhinia megalandra aqueous leaf extract on intestinal glucose absorption and uptake by enterocyte brush border membrane vesicles.
abstract: Aqueous extract of Bauhinia megalandra leaves was able to inhibit the intestinal glucose absorption in a concentration-dependent way and additive to phlorizine. Moreover, B. megalandra leaf extract drastically reduced the 14C-glucose uptake by enterocyte brush border membrane vesicles. The B. megalandra leaf extract administrated orally, simultaneously with glucose improved the glucose tolerance with a significant reduction of the 30-min peak. The extract did not have an effect on the glucose tolerance when glucose was administrated subcutaneously.
authors.affiliation: Sección de Bioquímica Médica, Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Apartado Postal 50587, Sabana Grande, Caracas, Venezuela. gonzalef@latinmail.com
authors.forename: F
authors.initials: F
authors.lastname: Gonzalez-Mujica
authors.forename: N
authors.initials: N
authors.lastname: Motta
authors.forename: A H
authors.initials: AH
authors.lastname: Márquez
authors.forename: J
authors.initials: J
authors.lastname: Capote-Zulueta
mesh_terms: D000284:Administration, Oral; D000818:Animals; D036481:Bauhinia; D002250:Carbon Radioisotopes / Q000378:metabolism; D003920:Diabetes Mellitus / Q000517:prevention & control; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002250:Carbon Radioisotopes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose