Dynamics of competitive evolution on a smooth landscape.
We study competitive DNA sequence evolution directed by in vitro protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and eventually reaches equilibrium. We explain this dynamical behavior within a continuum mean-field framework. Analytical results obtained on the motion of the pulse agree with simulations. Furthermore, finite population correction to the mean-field results are found to be insignificant.
Peng
Weiqun
W
Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California 92093-0319, USA.
Gerland
Ulrich
U
Hwa
Terence
T
Levine
Herbert
H
D001667:Binding, Competitive; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D019143:Evolution, Molecular; D006657:Histones / Q000378:metabolism; D007700:Kinetics; D008957:Models, Genetic; D017354:Point Mutation; D011485:Protein Binding; D013816:Thermodynamics
D004268:DNA-Binding Proteins; D006657:Histones; D004247:DNA