Model of recovery of locomotor ability after sensorimotor cortex injury in rats.
Animal models of locomotor recovery after brain injury provide tools for understanding the basic neurobiological processes that may underlie recovery after stroke in humans. Measurement of the ability of rats to traverse a narrow elevated beam has proven to be a particularly useful test of locomotor function. Repeated measurement of this behavior over time provides a simple method for quantifying the rate and degree of a rat's locomotor recovery after sensorimotor cortex injury and constitutes a tool for studying its mechanisms and possible treatment strategies. The model has proven particularly useful in predicting the effects of drugs on poststroke recovery in humans.
Goldstein
Larry B
LB
Duke Center for Cerebrovascular Disease, Department of Medicine (Neurology), Duke University and Department of Veterans Affairs Medical Center, Durham, NC, USA.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004195:Disease Models, Animal; D008124:Locomotion / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000503:physiopathology*; D020521:Stroke / Q000503:physiopathology*