title: Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia.
abstract: We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD.
  
  
  CONCLUSIONS
  We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia.
authors.affiliation: Department of Paediatrics, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 , Berlin, Germany.
authors.forename: Matthias T F
authors.initials: MTF
authors.lastname: Wolf
authors.affiliation: Department of Paediatrics, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 , Berlin, Germany. eva.mildenberger@ukbf.fu-berlin.de.
authors.forename: Eva
authors.initials: E
authors.lastname: Mildenberger
authors.affiliation: Department of Paediatrics, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 , Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lennert
authors.affiliation: Department of Pathology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Berlin, Germany.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anagnostopoulos
authors.affiliation: Department of Paediatrics, Otto-Heubner-Centrum für Kinder- und Jugendmedizin der Charité, Berlin, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Zinn
authors.affiliation: Department of Paediatrics, Otto-Heubner-Centrum für Kinder- und Jugendmedizin der Charité, Berlin, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Paul
authors.affiliation: Department of Paediatrics, Otto-Heubner-Centrum für Kinder- und Jugendmedizin der Charité, Berlin, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Keitzer
authors.affiliation: Department of Paediatrics, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 , Berlin, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Versmold
mesh_terms: D000361:Agammaglobulinemia / Q000209:etiology* / Q000821:virology; D002471:Cell Transformation, Neoplastic; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000821:virology; D008297:Male; D011014:Pneumonia / Q000209:etiology; D012008:Recurrence