title: Nineteen-millimeter prosthetic aortic valves allow normalization of left ventricular mass in elderly women.
abstract: BACKGROUND
  Implantation of small aortic valve prostheses has been reported to be associated with impaired left ventricular (LV) mass regression and incomplete resolution of symptoms although these data have been generated largely with male patients. Therefore we sought to determine the clinical and hemodynamic outcomes of female patients who received a 19-mm aortic valve.
  
  
  METHODS
  Between May 1995 and December 2000, 38 female patients (average age 73 years, range 42 to 89) underwent isolated aortic valve replacement (AVR; n = 22) or AVR plus coronary artery bypass graft surgery (CABG; n = 16) with a 19-mm aortic prosthesis. The average New York Heart Association (NYHA) class was 3.08 and of the 26 patients who had angina, 47.2% were in CCS class III or IV. Clinical and echocardiographic follow-up was done an average of 33.4 months (8 to 72) after surgery.
  
  
  RESULTS
  Operative mortality was 10.5%. Overall survival at an average of 33 months was 71.1%. The average NYHA class was 1.52 +/- 0.34 postoperatively (p < 0.001 versus preoperative) and 95% had no anginal symptoms or were in Canadian Cardiovascular Society class I. The LV mass index showed significant regression (114 +/- 11 g/m2 to 89 +/- 9 g/m2, p = 0.001) despite an effective orifice area index (EOAI) of 0.64 +/- 0.09 cm2/m2.
  
  
  CONCLUSIONS
  Despite a very small EOAI, elderly female patients with 19-mm prosthetic aortic valves can experience a satisfactory improvement in symptoms and normalization of LV mass. This finding suggests that small prosthetic aortic valves continue to have an application in contemporary cardiac surgical practice. The current perception of patient-prosthesis mismatch may need to be reconsidered for select populations.
authors.affiliation: Section of Cardiac Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Darren H
authors.initials: DH
authors.lastname: Freed
authors.forename: James W
authors.initials: JW
authors.lastname: Tam
authors.forename: Michael C
authors.initials: MC
authors.lastname: Moon
authors.forename: Gregory E J
authors.initials: GE
authors.lastname: Harding
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmad
authors.forename: Edward A
authors.initials: EA
authors.lastname: Pascoe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D011474:Prosthesis Design