title: [A clinical and histological study of Bio-Oss in combination with guided bone regeneration membrane technique].
abstract: OBJECTIVE
  To evaluate the reliability of Bio-Oss particles as bone grafts in combination with membrane-technique.
  
  
  METHODS
  6 small biopsy specimens were retrieved without causing iatrogenic damage in 6 patients (implant sites). The Donath's hard tissue section and micro grinding technique was adopted, and Leval Laczko staining method was used.
  
  
  RESULTS
  The histological results showed Bio-Oss particles were easily distinguished from the newly formed bone, but new bone was formed among different particles of Bio-Oss, no connective tissue was found. Intimate contact between newly formed bone and particles of the graft was present.
  
  
  CONCLUSIONS
  Bio-Oss appears to be highly biocompatible and osteoconductive. It can be used success fully as a bone substitute in combination with guided bone regeneration membrane technique.
authors.affiliation: Center of Implantation, Peking University School of Stomatology, Beijing 100081, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Qiu
authors.forename: Ye
authors.initials: Y
authors.lastname: Lin
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.forename: Georg
authors.initials: G
authors.lastname: Watzek
authors.forename: Kaihua
authors.initials: K
authors.lastname: Sun
mesh_terms: D000328:Adult; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D019647:Oral Surgical Procedures / Q000379:methods; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals