title: Absorbed dose to very low birth weight infants from 18F-fluorodeoxyglucose.
abstract: The radiation absorbed dose to very low birth weight infants from 18F-fluorodeoxyglucose was investigated. Ten newborns undergoing clinical positron tomography lung imaging were included in this study. Two consecutive 45-min dynamic scans immediately following intravenous injection of fluorodeoxyglucose were acquired; the first was over the head, and the second was over the chest. Time-activity curves were generated for the brain, heart wall, lungs, and, when visible, the kidneys. The cumulated activity measurements obtained were for the entire organ masses; these masses were much smaller than the corresponding organ masses for the newborn mathematical model. Patient-specific dosimetry yielded average doses of 2.5 x 10(-1) mGy MBq(-1) for the brain, 6.8 x 10(-1) mGy MBq(-1) for the heart wall, 2.2 x 10(-1) mGy MBq(-1) for the kidneys, and 4.4 x 10(-1) mGy MBq(-1) for the lungs. The effective dose was estimated to be 2.1 x 10(-1) mSv MBq(-1), which is half that previously published for newborns but still an order of magnitude higher than that for adults.
authors.affiliation: Department of Nuclear Medicine. McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5. nivens@mcmail.cis.mcmaster.ca
authors.forename: E
authors.initials: E
authors.lastname: Niven
authors.forename: C
authors.initials: C
authors.lastname: Nahmias
mesh_terms: D000042:Absorption; D001835:Body Weight; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D019102:Infant, Very Low Birth Weight; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000378:metabolism*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18