An introduction to pancreatic adenocarcinoma genetics, pathology and therapy.
Cancer is bad, but pancreatic cancer is especially so. Underlying the aggressive behavior of pancreatic cancer is a highly patterned set of biologic rules for its development. The accumulating discoveries regarding the genetic basis of pancreatic cancer and developments in the clinical management of the disease provide hope for meaningful improvements in the understanding and control of this disease.
Kern
Scott E
SE
Department of Oncology, Surgery, and Pathology, The Sidney Kimmel Comphrehensive Cancer Center, John's Hopkins, Baltimore, MD, USA. sk@jhmi.edu.
Hruban
Ralph H
RH
Hidalgo
Manuel
M
Yeo
Charles J
CJ
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy
D014408:Biomarkers, Tumor