title: Pathogenesis of idiopathic scoliosis revisited.
abstract: Scoliosis, a lateral deviation of the spine frequently associated with rotation, is not a specific disease but a deformity complicating many diseases. Curve progression is the major concern irrespective of the initiating cause. Idiopathic scoliosis is arguably postural in nature and in some subjects develops from intrauterine compression. Analysis of the pathogenesis leads to the conclusion that progression is due to an accelerated premature osteoarthrosis induced by insidious tissue fatigue of biomechanical origin. The chronic cumulative effect of repetitive tensile stresses applied asymmetrically to the postural deformity, manifested by loss of tensile strength and tissue cohesion, leads to fragility and eventual tissue disintegration of vertebrae, intervertebral discs, and laxity of ligaments. Early treatment, prevention, and avoidance of stresses that accentuate progression are of paramount import.
authors.affiliation: Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand. wstehbens@wnmeds.ac.nz
authors.forename: William E
authors.initials: WE
authors.lastname: Stehbens
mesh_terms: D000818:Animals; D006801:Humans; D010003:Osteoarthritis / Q000473:pathology / Q000503:physiopathology; D011187:Posture; D012600:Scoliosis / Q000473:pathology / Q000503:physiopathology*; D013131:Spine / Q000473:pathology*; D013314:Stress, Mechanical