Pituitary adenomas in adolescent patients with multiple endocrine neoplasia type 1.
Two juvenile patients with multiple endocrine neoplasia type 1 (MEN1) who developed pituitary adenomas are reported. The first case, a 14-year-old girl, developed prolactinoma and manifested delayed puberty and growth arrest. The second case, a 16-year-old boy, was asymptomatic and a pituitary adenoma accompanied by mild elevation of PRL and GH was identified through family screening. His growth and pubertal development was not impaired. Medication with bromocriptine was started for both cases with good therapeutic responses. These cases emphasize relevance of early screening of endocrine disorders for members of families with MEN1.
Oiwa
Ako
A
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Sakurai
Akihiro
A
Sato
Yoshihiko
Y
Sakuma
Takahiro
T
Yamashita
Koh
K
Katai
Miyuki
M
Aizawa
Toru
T
Hashizume
Kiyoshi
K
D000293:Adolescent; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D015175:Prolactinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*
D006727:Hormone Antagonists; D001971:Bromocriptine