[Role of missense mutation (M235T) in the angiotensinogen gene in development of cerebral ischemia].
Possible correlation of M/T polymorphism of angiotensinogen gene with risk of ischemic stroke and basic risk factors of cerebral pathology (levels of arterial pressure and blood cholesterol; presence of diabetes mellitus, coronary heart disease, or myocardial infarction in anamnesis; and stenosis of major cerebral arteries) was studied. It was shown that M/T polymorphic variants of angiotensinogen gene were factors determining neither clinical variant of cerebral ischemia development (acute ischemic stroke or chronic brain ischemia) nor formation of main risk factors of stroke.
Skvortsova
V I
VI
Department of Basic and Clinical Neurology, Russian State Medical University, Moscow.
Slominskiĭ
P A
PA
Kol'tsova
E A
EA
Tupitsyna
T I
TI
Miloserdova
O V
OV
Botsina
A Iu
AIu
Limborskaia
S A
SA
D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D011110:Polymorphism, Genetic
D000808:Angiotensinogen