Preoperative administration of methylprednisolone attenuates cytokine-induced respiratory failure after esophageal resection.
Proinflammatory cytokines have been implicated in mediating respiratory failure associated with major surgery. We investigated the effect of giving glucocorticoids preoperatively for the prophylaxis of surgical stress and the association of cytokine levels, such as interleukin-6 (IL-6) and interleukin-8 (IL-8), with oxygenation after esophagectomy. We studied 17 patients who underwent subtotal esophagectomy. Seven patients (steroid group) were chosen at random to be given methylprednisolone (10 mg/kg) and 10 patients (control group) to be given saline intravenously before operation. Plasma and bronchoalveolar lavage fluid (BALF) IL-8 levels in the control group were significantly higher than those in the steroid group. In both groups, plasma IL-6 levels were significantly higher than those in BALF, but in contrast, BALF IL-8 levels were significantly higher than plasma levels of IL-8 postoperatively. The PaO(2)/FiO(2) ratio was significantly reduced in the control group. The PaO(2)/FiO(2) ratio of the control group had significantly lower values than that of the steroid group. There was significant correlation between BALF IL-8 levels and the PaO(2)/FiO(2) ratio postoperatively. We conclude that preoperative administration of methylprednisolone may attenuate postoperative reduction of arterial oxygen saturation by suppressing the release of cytokines.
Takeda
Shinhiro
S
Division of Intensive Care Unit and Coronary Care Unit, Nippon Medical School Hospital and Department of Anesthesiology, Nippon Medical School, Tokyo, Japan. shinhiro@nms.ac.jp
Takeda
Shinhiro
S
Kim
Chol
C
Ikezaki
Hiroyuki
H
Nakanishi
Kazuhiro
K
Sakamoto
Atsuhiro
A
Okawa
Kei-ichi
K
Miyashita
Masao
M
Sasajima
Koji
K
Tajiri
Takashi
T
Tanaka
Keiji
K
Ogawa
Ryo
R
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D016209:Interleukin-8 / Q000502:physiology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D012131:Respiratory Insufficiency / Q000209:etiology / Q000517:prevention & control*
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D008775:Methylprednisolone