title: Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids.
abstract: [reaction: see text] Polymer-supported O-methyl, O-benzyl, and O-allyl-isoureas were prepared by copper(II)-catalyzed reaction of polymer-supported carbodiimide with the corresponding alcohols. These polymer-supported reagents were successfully employed to convert a series of carboxylic acids to methyl, benzyl, or allyl esters, in good yields. The products were obtained with high purity (>95% by NMR) after a simple resin filtration-solvent evaporation sequence.
authors.affiliation: Combinatorial Centre of Excellence, Chemistry Department, University of Southampton, Southampton, SO17 1BJ, United Kingdom.
authors.forename: Stefano
authors.initials: S
authors.lastname: Crosignani
authors.forename: Peter D
authors.initials: PD
authors.lastname: White
authors.forename: Rene
authors.initials: R
authors.lastname: Steinauer
authors.forename: Bruno
authors.initials: B
authors.lastname: Linclau