Association between a promoter variant in the monoamine oxidase A gene and schizophrenia.
Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n=133) and control subjects (n=377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (chi(2)=4.01, df=1, p<0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute and Hospital, R5:00, SE-171 76 Stockholm, Sweden. erikj@ks.se
Norton
Nadine
N
Forslund
Kaj
K
Mattila-Evenden
Marja
M
Rylander
Gunnar
G
Asberg
Marie
M
Owen
Michael J
MJ
Sedvall
Göran C
GC
D000328:Adult; D000483:Alleles; D005260:Female; D005387:Finland / Q000453:epidemiology; D015870:Gene Expression / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*
D008995:Monoamine Oxidase