title: [Leptospirosis-clinico-biological and therapeutical aspects-study of 256 cases].
abstract: Leptospirosis is a zooantroponosis manifested as an infectious disease with a severe evolution, with liver and renal failure and hemorrhagic manifestation. The aim of this study was to present the clinico-biological investigation and the therapeutical aspects of 256 cases of leptospirosis admitted in the Infectious Diseases Hospital Iasi during 4 years (1998-2001). The diagnosis was based on the study of clinico-biological and therapeutical parameters (risk factors, fever, mialgia, headache, algic, eruptive, meningeal, hepatorenal, hemorrhagic syndromes with the serological evidence of the serotypes of leptospirosis); most of the cases were registered in 1998 (23% cases), in adults (31.2%) and male (75.22%). All the patients were serologic confirmed with leptospirosis (RAL and RFC), and L. icterohaemorhagiae was isolated most frequently. The standard anti-leptospirosis treatment was administered with favorable evolution; 6 deaths were registered from the severe forms of the disease. The leptospirosis is an emergent disease with the possibility of severe evolution in some forms, with liver and renal failure.
authors.affiliation: Facultatea de Medicină Clinica de Boli Infecţioase, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: Mihaela Cătălina
authors.initials: MC
authors.lastname: Luca
authors.forename: Carmen
authors.initials: C
authors.lastname: Dorobăţ
authors.forename: Carmen
authors.initials: C
authors.lastname: Corcaci
authors.forename: Roxana
authors.initials: R
authors.lastname: Scurtu
authors.forename: V
authors.initials: V
authors.lastname: Luca
authors.forename: Doina
authors.initials: D
authors.lastname: Mihalache
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000372:Agglutination Tests; D002648:Child; D003168:Complement Fixation Tests; D005260:Female; D006801:Humans; D007919:Leptospira; D007922:Leptospirosis / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology