Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population.
The etiology of type 2 diabetes (DM) is polygenic. We investigated here genes and polymorphisms that associate with DM in the Japanese population. Single-nucleotide polymorphisms (SNPs) of 398 derived from 120 candidate genes were examined for association with DM in a population-based case-control study. The study group consisted of 148 cases and 227 controls recruited from Funagata, Japan. No evident subpopulation structure was detected for the tested population. The association tests were conducted with standard allele positivity tables (chi(2) tests) between SNP genotype frequency and case-control status. The independent association of the SNPs from serum triglyceride levels and body mass index was examined by multiple logistic regression analysis. A value of P<0.01 was accepted as statistically significant. Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM.
Daimon
Makoto
M
The Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. mdaimon@med.id.yamagata-u.ac.jp
Ji
Guijin
G
Saitoh
Tamotsu
T
Oizumi
Toshihide
T
Tominaga
Makoto
M
Nakamura
Takahiro
T
Ishii
Keisuke
K
Matsuura
Tadashi
T
Inageda
Kiyoshi
K
Matsumine
Hiroto
H
Kido
Takashi
T
Htay
Lwin
L
Kamatani
Naoyuki
N
Muramatsu
Masaaki
M
Kato
Takeo
T
D018528:ATP-Binding Cassette Transporters; D000368:Aged; D002352:Carrier Proteins / Q000235:genetics; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D009363:Neoplasm Proteins; D020641:Polymorphism, Single Nucleotide; D015221:Potassium Channels / Q000235:genetics; D024661:Potassium Channels, Inwardly Rectifying; D000090063:Proto-Oncogene Mas; D011955:Receptors, Drug / Q000235:genetics; D064233:Sulfonylurea Receptors; D025521:Tumor Suppressor Proteins
D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D000090063:Proto-Oncogene Mas; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors; D025521:Tumor Suppressor Proteins