title: 1,4-dibenzylpiperazines possess anticocaine activity.
abstract: N,N-dibenzylpiperazines have high affinity for sigma receptors, and we aimed to increase their anticocaine activity by introducing substituents known to enhance such activity in other sigma ligands. Ligands with high affinity for sigma-1 receptors resulted, but their activity in attenuating cocaine-induced convulsions did not correlate with sigma-1 binding affinity, and may be more closely related to their sigma-2 binding affinities.
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Pine Street, Baltimore, MD 21201, USA.
authors.forename: Abby
authors.initials: A
authors.lastname: Foster
authors.forename: Huifang
authors.initials: H
authors.lastname: Wu
authors.forename: Weibin
authors.initials: W
authors.lastname: Chen
authors.forename: Wanda
authors.initials: W
authors.lastname: Williams
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Bowen
authors.forename: Rae R
authors.initials: RR
authors.lastname: Matsumoto
authors.forename: Andrew
authors.initials: A
authors.lastname: Coop
mesh_terms: D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors*; D008024:Ligands; D051379:Mice; D010879:Piperazines / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D017480:Receptors, sigma / Q000378:metabolism; D012640:Seizures / Q000188:drug therapy / Q000517:prevention & control; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D010879:Piperazines; D017480:Receptors, sigma; D003042:Cocaine