title: Association of peripheral lymphadenopathy with anti-Ro and anti-La antibodies in a family with systemic lupus erythematosus.
abstract: We report here a mother and her two daughters suffering from systemic lupus erythematosus, accompanied by the presence of anti-Ro (SSA-52kD and 60kD) and anti-La (SSB) antibodies, and peripheral lymphadenopathy as the first manifestation of the disease. The expression of DR3 and B8 in all three affected family members suggests familiar predisposition to SLE. The differential diagnosis and clinical course are discussed.
authors.affiliation: Department of Medicine, Institute of Pediatrics Jagiellonian University, School of Medicine, Cracow, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Bukiej
authors.forename: Anetta
authors.initials: A
authors.lastname: Undas
authors.forename: Anna
authors.initials: A
authors.lastname: Pituch-Noworolska
authors.forename: Anna
authors.initials: A
authors.lastname: Chmielewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dyczek
authors.forename: Jacek
authors.initials: J
authors.lastname: Musiał
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D015795:HLA-B8 Antigen / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D010375:Pedigree
chemical_list: D000974:Antibodies, Antinuclear; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; C035356:SS-A antibodies; C035357:SS-B antibodies