Antidepressant-like effect of different estrogenic compounds in the forced swimming test.
The present study evaluated the possible antidepressant-like action of the natural estrogen 17beta-estradiol (E(2), 2.5-10 microg/rat), the synthetic steroidal estrogen ethinyl-estradiol (EE(2), 1.25-10.0 microg/rat), and the nonsteroidal synthetic estrogen, diethyl-stilbestrol (DES, 0.25-1.0 mg/rat) in ovariectomized adult female Wistar rats using the forced swimming test (FST). The behavioral profile induced by the estrogens was compared with that induced by the antidepressants fluoxetine (FLX, 2.5-10 mg/kg) and desipramine (DMI, 2.5-10 mg/kg). In addition, the temporal course of the antidepressant-like action of the estrogenic compounds was analyzed. FLX and DMI induced an antidepressant-like effect characterized by a reduced immobility and increased swimming for FLX and decreased immobility and increased climbing for DMI. Both E(2) and EE(2) produced a decrease in immobility and an increase in swimming, suggesting an antidepressant-like action. DES did not affect the responses in this animal model of depression at any dose tested. The time course analysis of the actions of E(2) (10 microg/rat) and EE(2) (5 microg/rat) showed that both compounds induced an antidepressant-like effect observed 1 h after their injection lasting for 2-3 days.
Estrada-Camarena
Erika
E
Depto de Farmacobiología CINVESTAV-IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, México. estrada@imp.edu.mx
Fernández-Guasti
Alonso
A
López-Rubalcava
Carolina
C
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004054:Diethylstilbestrol / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007103:Immobilization / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
D000928:Antidepressive Agents; D004967:Estrogens; D004997:Ethinyl Estradiol; D004958:Estradiol; D004054:Diethylstilbestrol