title: Neurotransmission of cognition, part 2. Selective NRIs are smart drugs: exploiting regionally selective actions on both dopamine and norepinephrine to enhance cognition.
abstract: Selective norepinephrine reuptake inhibitors such as atomoxetine increase both dopamine and norepinephrine in frontal cortex and may thereby enhance cognitive functioning in attention-deficit/hyperactivity disorder.
authors.affiliation: Neuroscience Education Institute, Carlsbad, Calif 92009, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000502:physiology; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011437:Propylamines / Q000494:pharmacology; D027981:Symporters / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000928:Antidepressive Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011437:Propylamines; C493227:SLC6A2 protein, human; D027981:Symporters; D000069445:Atomoxetine Hydrochloride; D004298:Dopamine; D009638:Norepinephrine