title: [Immune response in adult immunized with adsorbed DT-M anatoxin with reduced antigen content and Imovax-DT-adulte vaccine].
abstract: The comparative study of immune response after immunization of adults with adsorbed DT toxoid with reduced antigen content and Imovax-DT-adulte vaccine, as well as the safety of these preparations, was made. The study revealed that immunization of adults with adsorbed DT toxoid having reduced antigen content, made in two injections, and the injection of Imovax-DT-dulte vaccine, as well as the successive injection of these preparations, produced the same the levels of antitetanus immunity. Antidiphtheria immunity, evaluated by the number of seroconverted to diphtheria persons following two injections immunization was similar for the two preparations, while the level of antidiphtheria antibodies was higher in persons immunized with adsorbed DT toxoid. The immune stratum index was rather high among persons aged 16-29 years. This age group exhibited the highest number of persons, seropositive to both diphtheria and tetanus. Both vaccine preparations, adsorbed DT toxoid with reduced antigen content and Imovax-DT-adulte vaccine, were found to be equally capable of inducing autoimmune reactions in the vaccinees, detected by laboratory methods.
authors.affiliation: State Medical University, Rostov-on-Don, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Moskalenko
authors.forename: G G
authors.initials: GG
authors.lastname: Kharseeva
authors.forename: O I
authors.initials: OI
authors.lastname: Sylka
authors.forename: S I
authors.initials: SI
authors.lastname: Fedoruk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D015551:Autoimmunity; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004165:Diphtheria / Q000097:blood / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D006801:Humans; D007115:Immunization Schedule; D008875:Middle Aged; D013742:Tetanus / Q000097:blood / Q000276:immunology*; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid