Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis.
Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children with AD had significantly higher levels of serum SEB-specific immunoglobulin G (IgG; p = 0.0193), IgM (p = 0.011), and IgE (p = 0.0001) than the nonatopic children. The proportions of IgG, IgM, and IgE seropositivity in children with AD were 52.5% (21/40), 62.5% (25/40), and 67.5% (27/40), respectively. The levels of SEB-specific IgE and the severity of AD (p = 0.0004) were compared, but no correlation was seen for IgG or IgM. SEB may be involved in exacerbation of AD. SEB-specific IgE may be an important index of the clinical severity of AD. The SEB-specific IgG or IgM was produced during the exposure to the SEB antigen but may not be protective against SEB in AD.
Sohn
Myung Hyun
MH
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Kim
Cheol Hong
CH
Kim
Woo Kyung
WK
Jang
Gwang Cheon
GC
Kim
Kyu-Earn
KE
D000293:Adolescent; D000367:Age Factors; D000917:Antibody Formation / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology* / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007223:Infant; D007229:Infant Welfare; D008297:Male; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome
D004768:Enterotoxins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; C031818:enterotoxin B, staphylococcal