title: Tolerance to penicillin in Staphylococcus pyogenes isolated from skin infections.
abstract: The tolerance to penicillin of S. pyogenes has been mentioned in pharyngeal strains and associated by some authors with penicillin treatment failure in streptococcal angina. In this study we followed the presence of tolerance in S. pyogenes strains isolated from children hospitalized in the Clinic of Infantile Surgery and Clinic of Dermatology Iasi for skin infections. From 138 samples of pus examined we isolated 14 strains of S. pyogenes. In 7 strains we pointed out the tolerance to penicillin by both, beta-lactamase disc test and time-killing curve methods. We did not correlate to our cases the tolerance presence with penicillin treatment failure.
authors.affiliation: School of Medicine, University of Medicine and Pharmacy, Gr.T. Popa, Iaşi.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pânzaru
authors.forename: D
authors.initials: D
authors.lastname: Goţia
authors.forename: Tatiana
authors.initials: T
authors.lastname: Tăranu
authors.forename: Vasilica
authors.initials: V
authors.lastname: Ungureanu
authors.forename: Gabriela
authors.initials: G
authors.lastname: Coman
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology* / Q000627:therapeutic use; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D001618:beta-Lactamases
chemical_list: D010406:Penicillins; D001618:beta-Lactamases