title: Obsessions and compulsions in anorexia nervosa subtypes.
abstract: OBJECTIVE
  Obsession and compulsions in anorexia nervosa (AN) patients are often confused with the preoccupations and rituals that are characteristic of obsessive-compulsive disorder (OCD). We examined the type and frequency of characteristic OCD obsessions and compulsions in a large sample of AN patients.
  
  
  METHODS
  In personal interviews with 324 AN patients, we assessed lifetime histories of eating disorder symptomatology and obsessive-compulsive behaviors with valid semistructured interviews. Checklist category sums on the Yale-Brown Obsessive Compulsive Scale were compared between AN and OCD subjects using generalized estimating equations.
  
  
  RESULTS
  Lifetime obsessions and compulsions occurred in 68% of the AN restricting type and in 79.1% of the AN binge/purge type. The AN subgroups did not differ from OCD controls in frequency of obsessions in the symmetry and somatic categories or in the compulsion categories of ordering and hoarding. In all other categories, the AN subgroups had a significantly lower frequency compared with the OCD controls.
  
  
  CONCLUSIONS
  Some common phenotype characteristics shared by most AN and OCD patients suggest these disorders may share common brain behavioral pathways. However, the lack of complete overlap indicates they most likely have different loci of pathology within those pathways.
authors.affiliation: New York Presbyterian Hospital-Westchester Division, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA. kah29@cornell.edu
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Halmi
authors.forename: Suzanne R
authors.initials: SR
authors.lastname: Sunday
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Klump
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: James F
authors.initials: JF
authors.lastname: Leckman
authors.forename: Manfred
authors.initials: M
authors.lastname: Fichter
authors.forename: Allan
authors.initials: A
authors.lastname: Kaplan
authors.forename: Blake
authors.initials: B
authors.lastname: Woodside
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: Wade H
authors.initials: WH
authors.lastname: Berrettini
authors.forename: Mayadah
authors.initials: M
authors.lastname: Al Shabboat
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000523:psychology*; D003192:Compulsive Behavior / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D009770:Obsessive Behavior / Q000209:etiology / Q000523:psychology*; D010641:Phenotype; D012307:Risk Factors