Receptor sensitivity: when T cells lose their sense of self.
The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.
Hogquist
Kristin A
KA
University of Minnesota, Center for Immunology, 312 Church Street, S.E., Minneapolis, Minnesota 55455, USA. hogqu001@umn.edu
Starr
Timothy K
TK
Jameson
Stephen C
SC
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008024:Ligands; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D008024:Ligands; D011948:Receptors, Antigen, T-Cell