title: The potential role of bisphosphonates in prostate cancer.
abstract: Skeletal morbidity secondary to metastases and osteoporosis is common in patients with advanced prostate cancer. Despite the typically sclerotic nature of prostate cancer metastases, osteoclast mediated osteolysis may play a significant role. This review addresses the newly recognised antitumour effects of bisphosphonates in addition to their role in inhibiting osteoclast mediated bone resorption. Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed.
authors.affiliation: Department of Urology, St George's Hospital and Medical School, London, UK. goades@sghms.ac.uk
authors.forename: G M
authors.initials: GM
authors.lastname: Oades
authors.forename: J
authors.initials: J
authors.lastname: Coxon
authors.forename: K W
authors.initials: KW
authors.lastname: Colston
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000556:secondary*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001859:Bone Neoplasms / Q000098:blood supply / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000556:secondary*; D001862:Bone Resorption / Q000188:drug therapy*; D002118:Calcium / Q000378:metabolism; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D018450:Disease Progression; D006706:Homeostasis; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D010010:Osteoclasts / Q000187:drug effects; D010014:Osteolysis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000473:pathology*; D016032:Randomized Controlled Trials as Topic; D051381:Rats
chemical_list: D020533:Angiogenesis Inhibitors; D004164:Diphosphonates; D002118:Calcium