Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life.
In a case control study of genetic and lifestyle risk factors for Alzheimer's disease (AD), we obtained recalled food consumption frequencies translated to nutrients and averaged over 2 age periods of adult life, 20 to 39 and 40 to 59 years. The proportion of controls with the apolipoprotein E epsilon4 (APOE epsilon4) genotype was significantly higher in the lowest tertile of fat consumption (36.3% of energy) compared with controls with epsilon4 in the highest tertile of fat intake (44.6% of energy). Healthy older persons with the epsilon4 allele who survived to be included in this study may be protected with lower dietary fat intake and other healthy behaviors. Diet-genotype interactions may have important influences on disorders of later life.
Petot
Grace J
GJ
Department of Nutrition, The University Memory and Aging Center, Cleveland, OH 44120-1013, USA.
Traore
Fatoumata
F
Debanne
Sara M
SM
Lerner
Alan J
AJ
Smyth
Kathleen A
KA
Friedland
Robert P
RP
D000328:Adult; D000375:Aging; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D004041:Dietary Fats