Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.
Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.
Hiwale
A R
AR
Research and Development Division of Hindustan Antibiotics Limited, Pimperi, Pune 411 018, India.
Dhuley
J N
JN
Naik
S R
SR
D000470:Alkaloids; D000658:Amoxicillin / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D052117:Benzodioxoles; D001682:Biological Availability; D002434:Cefadroxil / Q000008:administration & dosage / Q000493:pharmacokinetics; D002439:Cefotaxime / Q000008:administration & dosage / Q000493:pharmacokinetics; D004347:Drug Interactions; D005260:Female; D008297:Male; D051379:Mice; D010880:Piperidines / Q000008:administration & dosage*; D053284:Polyunsaturated Alkamides; D051381:Rats
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D002434:Cefadroxil; D000658:Amoxicillin; D002439:Cefotaxime; C008922:piperine