title: Pharmacological evidence for beta3 adrenoceptors in the control of rat gastric acid secretion.
abstract: The effect of the beta3-adrenoceptor agonist BRL37344 on gastric acid secretion evoked by different secretory stimuli was investigated in anaesthetized rats with lumen-perfused stomachs in comparison with the beta2-adrenoceptor agonist clenbuterol. Intravenous injections of BRL37344 (1-10 micromol/kg) and clenbuterol (0.01-1 micromol/kg) dose-dependently reduced 2-deoxy-D-glucose-induced acid secretion, with BRL37344 about forty times less potent than clenbuterol. BRL37344 (0.1-3 micromol/kg) inhibited pentagastrin-induced acid output, whereas clenbuterol was effective only at high doses (10-100 micromol/kg). The inhibitory effect of BRL37344 on pentagastrin-induced acid secretion was not modified by the nonselective beta-adrenoceptor antagonist propranolol, but it was prevented by bupranolol, a beta3-adrenoceptor antagonist. Furthermore, neither BRL37344 (10 micromol/kg) nor clenbuterol (100 micromol/kg) modified the acid secretion induced by histamine. These data suggest that beta3 adrenoceptors have an inhibitory role in the control of rat gastric acid secretion induced by indirect stimuli.
authors.affiliation: Department of Human Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology, University of Parma, Via Volturno 39, 43100 Parma, Italy.
authors.forename: Maristella
authors.initials: M
authors.lastname: Adami
authors.forename: Gabriella
authors.initials: G
authors.lastname: Coruzzi
authors.forename: Emil
authors.initials: E
authors.lastname: Sotirov
authors.forename: Simone
authors.initials: S
authors.lastname: Bertini
authors.forename: Giulio
authors.initials: G
authors.lastname: Soldani
mesh_terms: D058673:Adrenergic beta-3 Receptor Antagonists; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D058673:Adrenergic beta-3 Receptor Antagonists