title: The impact of the paper of Edsall and Mehl (1940) on actin and actomyosin research.
abstract: The paper of Edsall and Mehl, 'The effect of denaturing agents on myosin, II. Viscosity and double refraction of flow', J. Biol. Chem. 133 (1940) 409-429, inspired our research on actin and actomyosin. It led to the specific purification of actin with magnesium ions and to the demonstration of the central role of the Mg(2+)-activated actomyosin ATPase in contraction of live muscle.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA. mbarany@uic.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Bárány
authors.forename: Kate
authors.initials: K
authors.lastname: Bárány
mesh_terms: D000199:Actins / Q000266:history* / Q000502:physiology; D000205:Actomyosin / Q000266:history* / Q000502:physiology; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001671:Biochemistry / Q000266:history; D049673:History, 20th Century; D008274:Magnesium / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology
chemical_list: D000199:Actins; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D008274:Magnesium