Intravascular ultrasound analysis of nonstented adjacent segments in diffuse in-stent restenosis treated with radiation therapy with a rhenium-188-filled balloon.
The effects of beta-radiation therapy on nonstented adjacent segments in in-stent restenosis have not been sufficiently evaluated. beta-radiation therapy for in-stent restenosis was performed with a (188)Re-MAG(3)-filled balloon. We evaluated the effects of beta-radiation therapy on nonstented adjacent segments in in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients who received radiation therapy vs. 9 control patients. The changes (Delta = follow-up - postintervention) of the external elastic membrane (EEM), the lumen, and other IVUS variables were compared between the segments that received radiation therapy and the control segments. The significant differences between the two groups were as follows: Delta EEM area was 0.3 mm(2) in the radiation vs. -1.0 mm(2) in the control (P = 0.005) and Delta lumen area was 0.2 mm(2) vs. -1.3 mm(2), respectively (P < 0.001). In conclusion, compared with the changes of vessel shrinkage in the control group, significant vessel enlargement occurred in the nonstented adjacent segments that received radiation therapy.
Hong
Myeong-Ki
MK
Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Park
Seong-Wook
SW
Moon
Dae-Hyuk
DH
Oh
Seung-Jun
SJ
Lee
Cheol Whan
CW
Kim
Young-Hak
YH
Lee
Jae-Whan
JW
Song
Jong-Min
JM
Kang
Duk-Hyun
DH
Song
Jae-Kwan
JK
Kim
Jae-Joong
JJ
Park
Seung-Jung
SJ
D000704:Analysis of Variance; D000800:Angioplasty, Balloon / Q000379:methods; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D016022:Case-Control Studies; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000628:therapy; D003331:Coronary Vessels / Q000528:radiation effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D011829:Radiation Dosage; D011868:Radioisotopes / Q000627:therapeutic use*; D012016:Reference Values; D012211:Rhenium / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
D011868:Radioisotopes; D012211:Rhenium