title: Anti-factor Xa monitoring of anticoagulation during cardiopulmonary bypass in a patient with antiphospholipid syndrome.
abstract: The activated clotting time (ACT) may be an unreliable monitor of coagulation for patients with the antiphospholipid syndrome. We describe a patient with antiphospholipid syndrome in whom adequate anticoagulation during cardiopulmonary bypass was confirmed by monitoring both the ACT and anti-factor Xa levels. The cardiopulmonary bypass was uneventful, and there were no thrombotic or bleeding complications. The use of anti-factor Xa levels provided confirmation of adequate anticoagulation (and reversal of anticoagulation) that was not possible using the ACT alone.
authors.affiliation: Department of Anaesthesia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, W.A. 6009.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lennon
authors.forename: N M
authors.initials: NM
authors.lastname: Thackray
authors.forename: N M
authors.initials: NM
authors.lastname: Gibbs
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood*; D000990:Antithrombin III / Q000302:isolation & purification*; D001777:Blood Coagulation; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D019934:International Normalized Ratio
chemical_list: D000990:Antithrombin III