In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.
Crowell
Andrea L
AL
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
Sanders-Lewis
Kolby A
KA
Secor
W Evan
WE
D000818:Animals; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D014011:Tinidazole / Q000494:pharmacology*; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects*
D014011:Tinidazole; D008795:Metronidazole