Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors.
Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported. Nonemissive indicator 2 reacts with DFP to give a cyclized compound 2+A- that shows a high emission due to its highly planar and rigid structure. Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection.
Zhang
Shi-Wei
SW
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Swager
Timothy M
TM
D002619:Chemical Warfare Agents / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000032:analysis*; D011725:Pyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
D002619:Chemical Warfare Agents; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D011725:Pyridines