CD36 deficiency and absent myocardial iodine-123-(R,S)-15-(p-iodophenyl)-3-methylpentadecanoic acid uptake in a girl with cardiomyopathy.
A 10-year-old girl presented left ventricular failure 1 month after the onset of hemolytic uremic syndrome (HUS) caused by an Escherichia coli O157 infection and was diagnosed as having dilated cardiomyopathy. Thallium myocardial scintigraphy showed normal perfusion, but no myocardial uptake of iodine-123-( R, S)-15-( p-iodophenyl)-3-methylpentadecanoic acid ((123)I-BMIPP) was observed. We analyzed the CD36 expression in platelets and monocytes by using a flowcytometer, and she turned out to have CD36 deficiency type I.


CONCLUSIONS
Some patients may be predisposed to myocardial damage in the presence of CD36 deficiency. It is necessary to clarify the etiological significance of the relationship between cardiac impairment and CD36 deficiency in children.
Teraguchi
Masayuki
M
Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, Moriguchi, 570-8506, Osaka, Japan. teraguch@takii.kmu.ac.jp
Ohkohchi
Hiroyuki
H
Ikemoto
Yumiko
Y
Higashino
Hirohiko
H
Kobayashi
Yohnosuke
Y
D018955:CD36 Antigens / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000378:metabolism*; D002648:Child; D004927:Escherichia coli Infections / Q000150:complications; D019453:Escherichia coli O157; D005227:Fatty Acids; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
D018955:CD36 Antigens; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C049338:iodofiltic acid