title: [Pleiotropic function of phosphoenolpyruvate-dependent phosphotransferase system in bacteria. Report 1].
abstract: Modern data (collected mainly in the 1998-2001 studies) about the transport of carbohydrates in bacteria, about the regulation of utilization of sugars via the glycolytic pathway as well as about the regulation of transformation of pyruvat into the products of secondary metabolism and of tricarboxylic acid cycle are presented in the survey. Issues, related with the regulation of synthesis of enzymes involved in the last mentioned process, are discussed in detail. Besides, the key pathways pertaining to the regulation of synthesis and activity of adenylate cyclase; elimination of the inductor in the gram-negative bacteria and entry of phage lambda DNA into E. coli are described. As for the gram-positive bacteria, properties of their main components (involved in catabolic repression), i.e. HPr, K/P, CcpA, CCpB and CcpC, cre, are presented. The mechanisms of catabolic repressions and of catabolic activation in bacteria are in the focus of attention. Finally, issues related with the structural organization of PTS as well as molecular-and-biological aspects of the interaction of proteins of the mentioned system are considered in the survey.
authors.affiliation: Hamaleya's State Research Institute for Epidemiology and Microbiology, Russian Academy of Medical Sciences.
authors.forename: V N
authors.initials: VN
authors.lastname: Gershanovich
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism*; D017852:Phosphotransferases (Nitrogenous Group Acceptor) / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D000255:Adenosine Triphosphate; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D017852:Phosphotransferases (Nitrogenous Group Acceptor); C022360:phosphoenolpyruvate-protein phosphotransferase