title: Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
abstract: Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.
authors.affiliation: Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA.
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Young Geun
authors.initials: YG
authors.lastname: Shin
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Hernán A
authors.initials: HA
authors.lastname: Navarro
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Ismail
authors.initials: I
authors.lastname: Rahman
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Cordell
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: Mansukh C
authors.initials: MC
authors.lastname: Wani
authors.forename: Monroe E
authors.initials: ME
authors.lastname: Wall
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D005419:Flavonoids; D010936:Plant Extracts; C477220:artobiloxanthone; C066727:artonin E