Significant linkage of Parkinson disease to chromosome 2q36-37.
Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
Pankratz
Nathan
N
Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA.
Nichols
William C
WC
Uniacke
Sean K
SK
Halter
Cheryl
C
Rudolph
Alice
A
Shults
Cliff
C
Conneally
P Michael
PM
Foroud
Tatiana
T
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005190:Family; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008025:Ligases / Q000235:genetics; D008126:Lod Score; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases
D005819:Genetic Markers; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases