Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors.
In yeast, growth and organelle segregation requires formin-dependent assembly of polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for cell growth, organelles for their segregation, and mRNA for fate determination. Several specific receptors have been identified that interact with the cargo-binding tails of the myosin Vs. A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle.
Bretscher
Anthony
A
Dept. of Molecular Biology and Genetics, Biotechnology Bldg., Cornell University, Ithaca, NY 14853, USA. apb5@cornell.edu
D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D002453:Cell Cycle / Q000502:physiology*; D020409:Molecular Motor Proteins / Q000378:metabolism; D024701:Myosin Type V / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism* / Q000648:ultrastructure; D033921:Vesicular Transport Proteins; D015003:Yeasts / Q000378:metabolism* / Q000648:ultrastructure
D020409:Molecular Motor Proteins; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; C472499:VAC17 protein, S cerevisiae; D033921:Vesicular Transport Proteins; D024701:Myosin Type V