title: Oral and genital lichenoid reactions associated with circulating autoantibodies to desmoplakins I and II: a novel target antigen or example of epitope spreading?
abstract: We describe the first reported case of persistent oral and genital lichenoid reactions associated with circulating antibodies to 250- and 215-kd proteins, compatible with desmoplakin I and II, respectively. We discuss the potential role of epitope spreading, leading to the novel development of specific autoantibodies to desmoplakin.
authors.affiliation: Department of Dermatologic Immunopathology, St John's Institute of Dermatology, Guy's King's and St Thomas' School of Medicine, St Thomas Hospital, London, United Kingdom. norider@wine.plala.or.jp
authors.forename: Noritaka
authors.initials: N
authors.lastname: Oyama
authors.forename: Jane F
authors.initials: JF
authors.lastname: Setterfield
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gratian
authors.forename: Balbir S
authors.initials: BS
authors.lastname: Bhogal
authors.forename: Pepe
authors.initials: P
authors.lastname: Shirlaw
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Challacombe
authors.forename: Martin M
authors.initials: MM
authors.lastname: Black
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis; D001707:Biopsy, Needle; D003598:Cytoskeletal Proteins / Q000009:adverse effects*; D051180:Desmoplakins; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D019226:Oral Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D014456:Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D003598:Cytoskeletal Proteins; C495294:DSP protein, human; D051180:Desmoplakins