Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.
Inhibition of human cytomegalovirus (HCMV) by 1263W94 was additive dosewise in combination with ganciclovir, acyclovir, and foscarnet. None of the commonly used anti-human immunodeficiency virus agents antagonized the inhibition of HCMV by 1263W94. The data were analyzed by a modified isobologram procedure that measures the strength and statistical significance of drug interactions.
Selleseth
Dean W
DW
GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. dean.w.selleseth@gsk.com
Talarico
Christine L
CL
Miller
Teresa
T
Lutz
Michael W
MW
Biron
Karen K
KK
Harvey
Robert J
RJ
D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D012263:Ribonucleosides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
D000998:Antiviral Agents; D001562:Benzimidazoles; D012263:Ribonucleosides; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole