Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats.
Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and an anti-platelet agent in biological systems with an anti-arrhythmic effect and a myocardial protective effect on ischemia-reperfusion injury. We examined the neuroprotective effect of honokiol in rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle cerebral artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed (treatment groups). The results showed that there was no significant hemodynamic change after intravenous infusion of honokiol at the dosages of 10(-8), 10(-7) and 10(-6) g/kg in both groups. However, honokiol significantly reduced the total volume of infarction at the doses of 10(-7) or 10(-6) g/kg in both pretreatment and treatment groups. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. This beneficial effect may be related to its antioxidant effect and anti-platelet aggregation activity.
Liou
Kuo-Tong
KT
Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
Lin
Su-Man
SM
Huang
Shiang-Suo
SS
Chih
Chun-Lien
CL
Tsai
Shen-Kou
SK
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control*; D007262:Infusions, Intravenous; D017705:Lignans; D031566:Magnolia; D008297:Male; D008517:Phytotherapy; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D000498:Allyl Compounds; D010636:Phenols
D000975:Antioxidants; D001713:Biphenyl Compounds; D017705:Lignans; D010975:Platelet Aggregation Inhibitors; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols