title: Association of the -1087 IL 10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians.
abstract: BACKGROUND
  Severe forms of periodontitis are suggested to have a genetic basis.
  
  
  OBJECTIVE
  The aim of the present investigation was to study association of an IL10 gene polymorphism (G to A transition at the -1087 position) with severe chronic periodontitis.
  
  
  METHODS
  Two groups of Swedish Caucasian subjects were included. One group consisted of 60 patients (aged 36-74 years; mean 54.5+/-8.5) with severe and generalized chronic periodontitis. The patients exhibited bone loss >50% at all teeth. Thirty-nine periodontally healthy subjects between 35-78 years of age (mean 51.0+/-10.9) were also recruited. DNA was isolated from peripheral blood cells and genotyping was performed by combination of PCR with restriction endonuclease mapping.
  
  
  RESULTS
  The proportion of subjects that exhibited the GG genotype was significantly larger in the group with severe periodontitis than in the periodontally healthy group. The difference regarding the occurrence of the GG genotype between the two groups was more conspicuous in non-smokers and yielded an odds ratio of 6.1. The G allele carriage in non-smokers was >90 % in the periodontitis group and was significantly higher than in the healthy controls.
  
  
  CONCLUSIONS
  It is suggested that the -1087 IL10 polymorphism in Caucasian subjects of a north European origin is associated with severe chronic periodontitis.
authors.affiliation: Department of Periodontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. berglundh@odontologi.gu.se
authors.forename: Tord
authors.initials: T
authors.lastname: Berglundh
authors.forename: Mauro
authors.initials: M
authors.lastname: Donati
authors.forename: Mirjana
authors.initials: M
authors.lastname: Hahn-Zoric
authors.forename: Lars-A
authors.initials: LA
authors.lastname: Hanson
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
mesh_terms: D000225:Adenine; D000328:Adult; D000368:Aged; D000483:Alleles; D016301:Alveolar Bone Loss / Q000235:genetics / Q000276:immunology; D016009:Chi-Square Distribution; D002908:Chronic Disease; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006147:Guanine; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics / Q000276:immunology*; D010519:Periodontium / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012907:Smoking; D013548:Sweden; D044465:White People / Q000235:genetics*
chemical_list: D016753:Interleukin-10; D006147:Guanine; D000225:Adenine