[Effect of redox-modified fibrinogen on blood leukocyte functions].
The influence of oxidized fibrinogen on the intensity of luminol-dependent chemilumin escence of blood leukocytes, stimulated by opsonized zymosan was studied. It was shown that the introduction of fibrinogen modified by UV-irradiation in to a suspension of cells resulted in a significant increase in the intensity of the luminol-dependent chemiluminescence of leukocytes. It was suggested that oxidized fibrinogen can influence blood leukocytes, enhancing their functional activity.
Zhambalova
B A
BA
Research Institute of Physicochemical Medicine, Ministry of Health of Russian Federation, Malaya Pirogovskaya ul. 1A, Moscow, 119992 Russia.
Azizova
O A
OA
D005340:Fibrinogen / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D010084:Oxidation-Reduction; D014466:Ultraviolet Rays; D015054:Zymosan
D008165:Luminol; D005340:Fibrinogen; D015054:Zymosan