title: Antiviral flavonoids from the root bark of Morus alba L.
abstract: A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods.
authors.affiliation: Department of Biology and Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.forename: Zhen-Dan
authors.initials: ZD
authors.lastname: He
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
authors.forename: Paul Pui-Hay
authors.initials: PP
authors.lastname: But
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests / Q000379:methods; D031625:Morus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D000212:Acyclovir