Tissue penetration by ertapenem, a parenteral carbapenem administered once daily, in suction-induced skin blister fluid in healthy young volunteers.
The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 micro g/ml (the MIC at which 90% of the isolates tested are eliminated) for the entire dosing interval. The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration.
Laethem
T
T
Merck & Co., Inc., Brussels, Belgium. tine_laethem@merck.com
De Lepeleire
I
I
McCrea
J
J
Zhang
J
J
Majumdar
A
A
Musson
D
D
Rogers
D
D
Li
S
S
Guillaume
M
M
Parneix-Spake
A
A
Deutsch
P
P
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001768:Blister / Q000378:metabolism*; D004334:Drug Administration Schedule; D000077727:Ertapenem; D005260:Female; D006801:Humans; D007769:Lactams; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D007769:Lactams; D047090:beta-Lactams; D000077727:Ertapenem