Gastrulation: PARtaking of the bottle.
Gastrulation in C. elegans embryos involves ingression of individual cells, but is driven by apical constriction of the kind that promotes migration of epithelial cell sheets. Recent work shows that PAR proteins, known for their role in polarization and unequal cell division, are also associated with the polarization that establishes this apical constriction.
Putzke
Aaron P
AP
Department of MCD Biology, University of California, Santa Barbara, CA 93106, USA.
Rothman
Joel H
JH
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D016764:Cell Polarity; D005775:Gastrula / Q000166:cytology* / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; C409406:PAR-1 protein, C elegans; D017346:Protein Serine-Threonine Kinases