Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnel.
On return from duty in North Solomons Province (including Bougainville Island), Papua New Guinea, 586 Australian Defence Force personnel received either primaquine (14-d) or tafenoquine (3-d) post-exposure malaria prophylaxis. Within 12 months, 6 of the 214 volunteers receiving primaquine and 7 of 378 receiving tafenoquine had developed vivax malaria. Overall, volunteers preferred the shorter course of tafenoquine.
Nasveld
Peter
P
Australian Defence Force Combined Health Element, Loloho, North Solomons Province, Papua New Guinea.
Kitchener
Scott
S
Edstein
Michael
M
Rieckmann
Karl
K
D000634:Aminoquinolines / Q000627:therapeutic use*; D000962:Antimalarials / Q000627:therapeutic use*; D001315:Australia; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000517:prevention & control*; D008297:Male; D008889:Military Personnel; D018512:Parasitemia / Q000517:prevention & control; D011319:Primaquine / Q000627:therapeutic use*
D000634:Aminoquinolines; D000962:Antimalarials; C055852:tafenoquine; D011319:Primaquine