title: Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays.
abstract: Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.
authors.affiliation: Division of Infectious Diseases (7881), Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. gmglez@yahoo.com.mx
authors.forename: Gloria M
authors.initials: GM
authors.lastname: González
authors.forename: Rolando
authors.initials: R
authors.lastname: Tijerina
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: David
authors.initials: D
authors.lastname: Loebenberg
authors.forename: John R
authors.initials: JR
authors.lastname: Graybill
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology; D011541:Pseudallescheria / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole