title: Apoptotic cells, including macrophages, are prominent in Theiler's virus-induced inflammatory, demyelinating lesions.
abstract: Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and approximately 17% remained unidentified. In situ hybridization revealed viral RNA in approximately 1% of apoptotic cells.
authors.affiliation: Department of Neurology, Northwestern University, Evanston, Illinois, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Schlitt
authors.forename: Matthew
authors.initials: M
authors.lastname: Felrice
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Jelachich
authors.forename: Howard L
authors.initials: HL
authors.lastname: Lipton
mesh_terms: D000818:Animals; D017209:Apoptosis; D018188:Cardiovirus Infections / Q000473:pathology* / Q000821:virology*; D003711:Demyelinating Diseases / Q000473:pathology* / Q000821:virology*; D016679:Genome, Viral; D017403:In Situ Hybridization; D008264:Macrophages / Q000473:pathology* / Q000821:virology*; D051379:Mice; D010641:Phenotype; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D013116:Spinal Cord / Q000473:pathology / Q000821:virology; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology; D017945:Theilovirus / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D012367:RNA, Viral