title: A placebo-controlled pharmacodynamic and pharmacokinetic interaction study between tamsulosin and acenocoumarol.
abstract: OBJECTIVE
  To evaluate pharmacokinetic and pharmacodynamic interactions between tamsulosin and acenocoumarol.
  
  
  METHODS
  Twelve healthy volunteers received tamsulosin 0.4 mg or placebo once daily for 9 days in a double-blind, cross-over study. On day 5 of each study period, a single 10-mg oral dose of racemic acenocoumarol was administered.
  
  
  RESULTS
  The ratios (point estimates (90% confidence intervals)) of values in the presence and absence of tamsulosin were: AUCPT 1.01 (0.98, 1.03); maximum prothrombin time (Ptmax) 0.99 (0.94, 1.05); AUC (R)-acenocoumarol 1.02 (0.90, 1.16), and AUC (S)-acenocoumarol 1.03 (0.89, 1.20). Both combinations, tamsulosin and placebo with acenocoumarol, were well-tolerated.
  
  
  CONCLUSIONS
  Multiple doses of tamsulosin had no effect on the pharmacokinetics or pharmacodynamics of a single high dose of acenocoumarol.
authors.affiliation: Medeval, Skelton House, Manchester, UK. p.rolan@medeval.com
authors.forename: P
authors.initials: P
authors.lastname: Rolan
authors.forename: I J
authors.initials: IJ
authors.lastname: Terpstra
authors.forename: C
authors.initials: C
authors.lastname: Clarke
authors.forename: F
authors.initials: F
authors.lastname: Mullins
authors.forename: J N
authors.initials: JN
authors.lastname: Visser
mesh_terms: D000074:Acenocoumarol / Q000493:pharmacokinetics* / Q000494:pharmacology; D000284:Administration, Oral; D000293:Adolescent; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D000925:Anticoagulants / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D013449:Sulfonamides / Q000494:pharmacology*; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D000925:Anticoagulants; D013449:Sulfonamides; D000077409:Tamsulosin; D000074:Acenocoumarol