Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays.
Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.
González
Gloria M
GM
Division of Infectious Diseases (7881), Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. gmglez@yahoo.com.mx
Tijerina
Rolando
R
Najvar
Laura K
LK
Bocanegra
Rosie
R
Rinaldi
Michael G
MG
Loebenberg
David
D
Graybill
John R
JR
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology; D011541:Pseudallescheria / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole