title: Efficacy of micafungin alone or in combination against systemic murine aspergillosis.
abstract: We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.
authors.affiliation: University of Rovira i Virgili, Reus, Spain.
authors.forename: Javier Capilla
authors.initials: JC
authors.lastname: Luque
authors.forename: Karl V
authors.initials: KV
authors.lastname: Clemons
authors.forename: David A
authors.initials: DA
authors.lastname: Stevens
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005260:Female; D017964:Itraconazole / Q000008:administration & dosage; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D000077551:Micafungin; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D017964:Itraconazole; D000666:Amphotericin B; D000077551:Micafungin