Windows into development: historic, current, and future perspectives on transgenic zebrafish.
The recent explosion of transgenic zebrafish lines in the literature demonstrates the value of this model system for detailed in vivo analysis of gene regulation and morphogenetic movements. The optical clarity and rapid early development of zebrafish provides the ability to follow these events as they occur in live, developing embryos. This article will review the development of transgenic technology in zebrafish as well as the current and future uses of transgenic zebrafish to explore the dynamic environment of the developing vertebrate embryo.
Udvadia
Ava J
AJ
Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA. ajudvad@acpub.duke.edu
Linney
Elwood
E
D000818:Animals; D030801:Animals, Genetically Modified; D015509:Developmental Biology / Q000266:history / Q000639:trends; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018390:Gene Targeting / Q000266:history / Q000639:trends; D005818:Genetic Engineering / Q000266:history / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D008297:Male; D015027:Zebrafish / Q000196:embryology / Q000235:genetics*