Cerebral primitive neuroectodermal tumour in a heifer.
A primitive neuroectodermal tumour (PNET) replacing the thalamus was discovered in an 18-month-old Prim'Holstein heifer. Microscopical examination of the tumour showed large sheets of densely packed cells with occasional Homer-Wright and perivascular rosettes. Neoplastic cells were small with ill-defined borders, scant cytoplasm and ovoid, irregularly shaped nuclei. Immunolabelling was positive for vimentin and neuron-specific enolase, in agreement with previous reports of PNETs in human beings and animals. This appears to be the first report of cerebral PNET in cattle.
Lucas
M-N
MN
Unité d'Anatomie Pathologique, Ecole Nationale Vétérinaire de Nantes, Atlanpôle, La Chantrerie, BP 40706 F-44307, Nantes cedex 03, France.
Nguyen
F
F
Abadie
J
J
Kane
Y
Y
Cuillière
P
P
Wyers
M
M
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D007124:Immunoenzyme Techniques / Q000662:veterinary; D017599:Neuroectodermal Tumors / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013788:Thalamus / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D014746:Vimentin; D010751:Phosphopyruvate Hydratase