title: Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation.
abstract: We measure the tissue oxygen and haemoglobin concentrations in the rat brain during modulation of inhaled oxygen concentration (FiO2), using non-invasive frequency domain near-infrared oximetry. The rise in oxygenated haemoglobin concentration and the decline in deoxygenated haemoglobin concentration are demonstrated in correspondence with the modulation of FiO2, which is changed from 20% to 100% in increments of 20%. Furthermore, the tissue oxygenation saturation also shows the corresponding trend and changes ranging from approximately 70% to 90%. The relative changes in deoxygenated haemoglobin concentration are compared to the blood-oxygenation-level-dependent (BOLD) MRI signal recorded during a similar FiO2 protocol. A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed.
authors.affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. chenyu@mail.med.upenn.edu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Dharmesh R
authors.initials: DR
authors.lastname: Tailor
authors.forename: Xavier
authors.initials: X
authors.lastname: Intes
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism* / Q000502:physiology; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013223:Statistics as Topic; D013382:Subtraction Technique
chemical_list: D006454:Hemoglobins; D010100:Oxygen