title: Efficacy and safety of sequential amoxicillin-clavulanate in the treatment of anaerobic lung infections.
abstract: In order to assess the efficacy and safety of amoxicillin-clavulanate for the treatment of anaerobic lung infection, 40 patients with lung abscess or necrotizing pneumonia were given sequential amoxicillin-clavulanate therapy. All patients received intravenous amoxicillin-clavulanate (2 g/200 mg/8 h), which was switched to oral form (1 g/125 mg/8 h) after clinical improvement. Mean duration of antibiotic therapy was 43.5 days. Microbiological documentation was obtained in 53% of cases. All but 1 of the 48 microorganisms isolated were susceptible to amoxicillin-clavulanate. The drug was well tolerated by the patients and no severe adverse effects were observed. At the end of treatment all patients were considered cured. The 35 patients assessed at long-term follow-up visit remained disease-free.
authors.affiliation: Infectious Disease Service, Hospital de Bellvitge, University of Barcelona, Feixa Llarga sn, 08907, L'Hospitalet, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Fernández-Sabé
authors.forename: J
authors.initials: J
authors.lastname: Carratalà
authors.forename: J
authors.initials: J
authors.lastname: Dorca
authors.forename: B
authors.initials: B
authors.lastname: Rosón
authors.forename: F
authors.initials: F
authors.lastname: Tubau
authors.forename: F
authors.initials: F
authors.lastname: Manresa
authors.forename: F
authors.initials: F
authors.lastname: Gudiol
mesh_terms: D000328:Adult; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects* / Q000627:therapeutic use*; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000382:microbiology; D008171:Lung Diseases / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination