title: Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens root in rodents.
abstract: The effect of methanolic extract of Asparagus pubescens was investigated on chemical, thermal-induced pain as well as fresh egg albumin-induced inflammation and pentylenetetrazol (PTZ)-induced convulsion in rodents. The extract dose-dependently (0.25-1.5 g/kg) inhibited acetic acid-induced writhing, formalin-induced pain licking and hot plate-induced pain in mice. The extract significantly inhibited both the fresh egg albumin-induced inflammation in rats as well as PTZ-induced convulsion in mice. These inhibitions were statistically significant (P < 0.02-0.001). It increased the latencies of both clonic and tonic convulsions and delayed their mortalities. Its ability to reduce both neurogenic and non-neurogenic pains may be related to its active constituents such as tannins, saponins, steroid and flavonoids.
authors.affiliation: Department of Pharmacology, College of Medical Sciences, University of Maiduguri, PMB 1069, Maiduguri, Nigeria. nwaforp@unimaid.edu.ng
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nwafor
authors.forename: F K
authors.initials: FK
authors.lastname: Okwuasaba
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D005557:Formaldehyde; D006358:Hot Temperature; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D019668:Liliaceae / Q000737:chemistry*; D000432:Methanol; D051379:Mice; D009549:Nigeria; D010047:Ovalbumin; D010147:Pain Measurement / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012997:Solvents
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D010047:Ovalbumin; D019342:Acetic Acid; D010433:Pentylenetetrazole; D000432:Methanol