Latest development in viral vectors for gene therapy.
Gene therapy includes the application of various viral vectors, which represent most types and families of viruses, suitable for infection of mammalian host cells. Both hereditary diseases and acquired illnesses, such as cancer, can be targeted. Because of the various properties of each viral vector, the definition of their application range depends on factors such as packaging capacity, host range, cell- or tissue-specific targeting, replication competency, genome integration and duration of transgene expression. Recent engineering of modified viral vectors has contributed to improved gene delivery efficacy.
Lundstrom
Kenneth
K
Regulon Inc./BioXtal., Chemin des Croisettes 22, CH-1066 Epalinges, Switzerland. kenneth.lundstrom@mepnet.org
D000256:Adenoviridae / Q000235:genetics; D000524:Alphavirus / Q000235:genetics; D000229:Dependovirus / Q000235:genetics; D018390:Gene Targeting / Q000379:methods* / Q000639:trends*; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods / Q000639:trends; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D005822:Genetic Vectors / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D018139:Simplexvirus / Q000235:genetics; D014780:Viruses / Q000235:genetics*