Oral and genital lichenoid reactions associated with circulating autoantibodies to desmoplakins I and II: a novel target antigen or example of epitope spreading?
We describe the first reported case of persistent oral and genital lichenoid reactions associated with circulating antibodies to 250- and 215-kd proteins, compatible with desmoplakin I and II, respectively. We discuss the potential role of epitope spreading, leading to the novel development of specific autoantibodies to desmoplakin.
Oyama
Noritaka
N
Department of Dermatologic Immunopathology, St John's Institute of Dermatology, Guy's King's and St Thomas' School of Medicine, St Thomas Hospital, London, United Kingdom. norider@wine.plala.or.jp
Setterfield
Jane F
JF
Gratian
Matthew J
MJ
Bhogal
Balbir S
BS
Shirlaw
Pepe
P
Challacombe
Stephen J
SJ
Black
Martin M
MM
D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis; D001707:Biopsy, Needle; D003598:Cytoskeletal Proteins / Q000009:adverse effects*; D051180:Desmoplakins; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D019226:Oral Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D014456:Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies; D003598:Cytoskeletal Proteins; C495294:DSP protein, human; D051180:Desmoplakins