The effect of food components on the absorption of P-gp substrates: a review.
P-glycoprotein (P-gp), a well characterized efflux mechanism which is functionally expressed in the intestinal epithelium, constitutes, along with intestinal metabolism, an important part of the biochemical barrier function of the intestinal mucosa. This efflux carrier may be responsible for limiting the bioavailability of several drugs after oral intake. Recently, increasing attention is being paid to the interaction of dietary components with the intestinal absorption of drugs. This review focuses on the modulating capacity of food components on the intestinal absorption of P-gp substrates. The possible P-gp inhibitory effects of several dietary constituents are discussed. In addition, this review will also focus on the effect of several bioflavonoids on the P-gp-mediated efflux of drugs. As the role of P-gp (and other efflux carriers, including multidrug resistance-associated proteins and breast cancer resistance protein) in limiting the bioavailability of drugs becomes more clear, more research is required firstly to identify the effect of dietary compounds on these efflux carriers and secondly to reveal the clinical relevance of this interaction.
Deferme
Sven
S
Laboratorium voor Farmacotechnologie en Biofarmacie, Herestraat 49, Gasthuisberg, 3000 Leuven, Belgium.
Augustijns
Patrick
P
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005419:Flavonoids / Q000494:pharmacology*; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship
D018435:ATP Binding Cassette Transporter, Subfamily B; D005419:Flavonoids