Controling the rate of protein release from polyelectrolyte complexes.
Extended protein release from readily prepared, water-insoluble complexes with oppositely charged polyions is explored. Using hen egg-white lysozyme as a model, its sustained release from such complexes with a number of polyanions under physiological conditions has been demonstrated and rationalized. The rate of release varies orders of magnitude and is controlled by the nature of the polyanion (decreasing upon increase in its linear charge density, length, and hydrophobicity) and the complex particle size (the larger the particles, the slower the release).
Kamiya
Noriho
N
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Klibanov
Alexander M
AM
D000464:Alginates / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D004527:Egg Proteins / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry*; D005240:Feasibility Studies; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008422:Materials Testing; D008863:Microspheres; D009113:Muramidase / Q000008:administration & dosage* / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004527:Egg Proteins; D004573:Electrolytes; D006603:Hexuronic Acids; D014867:Water; D020723:Glucuronic Acid; D009113:Muramidase