title: [A case of AIDS-associated Haemophilus influenzae pneumonia with diffuse reticulonodular shadows].
abstract: A 32-year-old male was admitted to our hospital complaining of fever and dyspnea on effort. Laboratory data on admission indicated leukocytosis and elevation of C-reactive protein. A chest radiograph showed diffuse reticulonodular shadows in both lower lung fields, and a chest computed tomography showed centrilobular reticulonodular opacity. Bronchoscopic findings revealed a large amount of slightly yellowish secretion in all bronchi. Cells found in the bronchoalveolar lavage fluid (BALF) included 61% neutrophils. Haemophilus influenzae was isolated from cultures of the BALF and sputum. Transtracheal lung biopsy specimens showed focal infiltration of neutrophils in the alveoli, and the pathological findings in the lung were compatible with bronchiolopneumonia. Since the CD4/CD8 ratio was 0.09 and a positive reaction was obtained for anti-human immunodeficiency virus (HIV) antibody, HIV-associated pneumonia due to H. influenzae was diagnosed. Seven days' administration of cefozopran improved the patient's condition. It is interesting that radiological findings are often unusual in HIV-infected patients with H. influenzae pneumonia.
authors.affiliation: Second Department of Internal Medicine, Nara Medical University.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.forename: Takahito
authors.initials: T
authors.lastname: Nakamura
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Yoshimoto
authors.forename: Ken
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kei
authors.initials: K
authors.lastname: Mori
authors.forename: Koichi
authors.initials: K
authors.lastname: Maeda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hamada
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mikasa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Narita
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D006192:Haemophilus Infections / Q000188:drug therapy / Q000209:etiology*; D006193:Haemophilus influenzae; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology*; D000097586:Cefozopran
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097586:Cefozopran