title: Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
abstract: Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n=102) with a group of clinically healthy subjects (n=102), and found that the MI group had a significantly high frequency of 501G/C+501C/C (38.2%) compared with the healthy group (17.6%; p<0.002). The odds ratio for the risk of MI associated with the 501G/C+501C/C genotype was 2.89 (95% CI, 1.51-5.53). These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI. Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.
authors.affiliation: The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Tatsuguchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Furutani
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Hinagata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Furutani
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Imamura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kawana
authors.forename: Tomoh
authors.initials: T
authors.lastname: Masaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kasanuki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sawamura
authors.forename: Rumiko
authors.initials: R
authors.lastname: Matsuoka
mesh_terms: D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D009154:Mutation; D020125:Mutation, Missense; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D011973:Receptors, LDL / Q000235:genetics* / Q000378:metabolism*; D051131:Receptors, Oxidized LDL; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D051127:Scavenger Receptors, Class E
chemical_list: C495137:OLR1 protein, human; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E