Inhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma.
A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS.
Hashimoto
Shigeatsu
S
3rd Department of Internal Medicine, Fukushima Medical University, School of Medicine, Fukushima, Japan. raijinsh@fmu.ac.jp
Yatabe
Jun-ichi
J
Midorikawa
Sanae
S
Sanada
Hironobu
H
Watanabe
Tsuyoshi
T
D000052:Acanthosis Nigricans / Q000150:complications; D000172:Acromegaly / Q000150:complications; D000236:Adenoma / Q000378:metabolism*; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008090:Lisuride / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008597:Menstrual Cycle / Q000187:drug effects; D010053:Ovary / Q000473:pathology / Q000503:physiopathology*; D010186:Pancreatic Function Tests; D010901:Pituitary Function Tests; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D013799:Theca Cells / Q000502:physiology
D015259:Dopamine Agents; D007328:Insulin; D019382:Human Growth Hormone; C006208:dironyl; D001971:Bromocriptine; D007334:Insulin-Like Growth Factor I; D008090:Lisuride