title: Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy.
abstract: OBJECTIVE
  To evaluate the relationship between optic nerve head (ONH) measurements generated by optical coherence tomography (OCT; versions 2 and 3) and confocal scanning laser ophthalmoscopy (CSLO) and to compare the association between OCT and CSLO ONH measurements with glaucoma disease status, as determined by clinical evaluation and perimetry.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  In a prospective study in the glaucoma service of an academic department of ophthalmology, 159 eyes (97 subjects) and 77 eyes (44 subjects) were recruited in two separate periods. All subjects were scanned with a CSLO device. Subjects tested within the first period of recruitment were scanned with OCT version 2 and in the second period with OCT version 3. The main outcome measure was the correlation between automatic and manually defined OCT ONH measurements and the correlation of CSLO and OCT ONH measurements between devices and with glaucoma disease status.
  
  
  RESULTS
  A high correlation was found between ONH measurements obtained by the automatic determination of ONH margin and those obtained by manual tracing of the disk margin (r =.93 to.98). Optical coherence tomography and CSLO ONH measurements were highly correlated. Optical coherence tomography-measured mean disk area was significantly larger than that measured by CSLO, as were all other disk size-related parameters. The areas under the receiver operator characteristic (AROC) curves for the associations between CSLO and OCT ONH measurements and clinical diagnosis were found to be similar and in the range of 0.47 to 0.79 for both devices.
  
  
  CONCLUSIONS
  Automated OCT ONH measurements correlate highly with those obtained by manual tracing of disk margin. Optical coherence tomography and CSLO ONH analyses are highly correlated and have similar associations with glaucoma disease status.
authors.affiliation: New England Eye Center, Tufts School of Medicine, Boston, Massachusetts 02111, USA. jss2002@attbi.com
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Taline
authors.initials: T
authors.lastname: Farra
authors.forename: Ellen
authors.initials: E
authors.lastname: Hertzmark
authors.forename: Ali
authors.initials: A
authors.lastname: Aydin
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Lelia A
authors.initials: LA
authors.lastname: Paunescu
mesh_terms: D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007368:Interferometry; D007429:Intraocular Pressure; D007834:Lasers; D008027:Light; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D015203:Reproducibility of Results; D014054:Tomography / Q000379:methods; D014792:Visual Acuity; D058609:Visual Field Tests