Chronic active EB virus infection complicated with IgG3 subclass deficiency: an adult case treated with intravenous immunoglobulin and IFN-alpha.
A 60-year-old man presented with recurrent genital and oral ulcers, necrotic papules on his face and scalp, spiking fever and indurated skin erythema on the trunk. A diagnosis of chronic active Epstein-Barr virus infection and IgG3 subclass deficiency was made, and he was supplemented by intravenous gammaglobulin injection. The spiking fever was resistant to treatment, but the addition of systemic interferon-alpha therapy was partially effective in treating his clinical symptoms, although the patient eventually died from pulmonary effusions and cardiac insufficiency.
Mitsui
Hiroshi
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. mitsuih-der@h.u-tokyo.ac.jp
Komine
Mayumi
M
Shirai
Akira
A
Kanda
Naoko
N
Asahina
Akihiko
A
Okochi
Hitoshi
H
Hitomi
Shigemi
S
Kimura
Satoshi
S
Tamaki
Kunihiko
K
D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000628:therapy*; D006801:Humans; D017099:IgG Deficiency / Q000150:complications* / Q000628:therapy*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D016756:Immunoglobulins, Intravenous; D016898:Interferon-alpha