Effect of oral magnesium supplementation on experimental pre-eclampsia induced by prolonged blockade of nitric oxide synthesis in pregnant rats.
Nitric oxide inhibitor L-NAME when given alone caused a significant rise in both systolic and diastolic pressure, an increase in 24 hr urinary protein excretion and reduction in weight of the litter as compared to control group. Supplementation of MgSO4 at lower dose (250 mg/kg) did not inhibit this pre-eclamptic effect of L-NAME; but in higher doses (500 and 750 mg/kg), it inhibited the pre-eclamptic action of L-NAME. The results suggest that administration of MgSO4 improves the foetal outcome and significantly prevents the development of symptoms of pre-eclampsia like hypertension and proteinuria.
Pandhi
P
P
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India. drpandhi@yahoo.com
Saha
L
L
Malhotra
S
S
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000633:toxicity; D005260:Female; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D011225:Pre-Eclampsia / Q000503:physiopathology / Q000517:prevention & control*; D011247:Pregnancy; D011507:Proteinuria / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D008278:Magnesium Sulfate; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester