title: Total synthesis of (+/-)-trachyspic acid and determination of the relative configuration.
abstract: [reaction: see text] The first total synthesis of (+/-)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr(II)/Ni(II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Hirai
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ooi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Esumi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Iwabuchi
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama