Abnormal endothelial function in young African-American females: discordance with blood flow.
In this pilot study, we sought to compare the vasodilatory and hemodynamic properties of the peripheral vasculature in the forearms of young, healthy African-American females to similarly matched white females. We used high-resolution ultrasound of the brachial artery to evaluate 11 African-American females and 8 white females. When normalized to nitrate-induced dilation, endothelium-dependent dilation was reduced in young African American females compared to white females (0.6 in African American females compared to 1.0 in white females). These results indicate the need for a larger study to examine this phenomenon.
Bransford
T L
TL
Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA.
St Vrain
J A
JA
Webb
M
M
D000328:Adult; D001741:Black or African American; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D005996:Nitroglycerin / Q000494:pharmacology*; D010865:Pilot Projects; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D034941:Upper Extremity; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014666:Vasomotor System / Q000502:physiology; D044465:White People
D005996:Nitroglycerin