[Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency].
Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI-1 activity. A 21-year-old male with congenital PAI-1 deficiency underwent wisdom teeth extraction of the mandible under general anesthesia using propofol, nitrous oxide, sevoflurane, fentanyl, and vecuronium. No complications including prolonged bleeding and rebleeding after the operation were observed because hemostatic management was successful by using intravenous tranexamic acid.
Kajihara
Atsuhisa
A
Department of Anesthesiology, Nara Medical University, Kashihara 634-8522.
Kurehara
Hiroyoshi
H
Kitaguchi
Katsuyasu
K
Furuya
Hitoshi
H
Morimoto
Yoshinari
Y
Kirita
Tadaaki
T
Fukuda
Kazuyoshi
K
Takahashi
Yukihiro
Y
D000328:Adult; D000768:Anesthesia, General; D000933:Antifibrinolytic Agents / Q000008:administration & dosage; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D019990:Perioperative Care; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency*; D014081:Tooth Extraction; D014148:Tranexamic Acid / Q000008:administration & dosage; D016896:Treatment Outcome
D000933:Antifibrinolytic Agents; D017395:Plasminogen Activator Inhibitor 1; D014148:Tranexamic Acid