Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection.
Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (K(a)) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the K(a) of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pK(a) values obtained through the method were in agreement with the values by typical spectrophotometric method.
Hu
Qin
Q
Department of Physiology and Pharmacology, Nanjing Medical University, Jiangsu 210029, Nanjing, People's Republic of China.
Hu
Gang
G
Zhou
Tianshu
T
Fang
Yuzhi
Y
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods
D000903:Antibiotics, Antineoplastic