Human herpesvirus-6 has no apparent influence on course of HCV hepatitis, but may complicate HBV hepatitis and alcoholic liver disease. A pilot study.
Human herpesvirus-6 (HHV-6) is a widespread virus with occasional reactivation and a potential hepatotropism. The present study was undertaken to investigate the frequency of HHV-6 reactivation in viral (HCV, HBV) and alcoholic liver diseases and its implication for the course of the primary disease. Serological and immunohistochemical tests were done to document viral activity, hepatocellular apoptosis or proliferation, and autoantibody formation. While the course of HCV remains apparently uninfluenced by HHV-6, HBV hepatitis and alcoholic liver disease show a higher incidence of autoantibody formation if HHV-6 is present. The data of this pilot study warrant more extensive investigations of the clinical pathology of HHV-6 in liver diseases.
Rojo
Julieta
J
Banco de Sangre, Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico, D.F. julietarojomx@yahoo.com.mx
Simoes
Patricia
P
Krueger
Gerhard R F
GR
Humberto
Cruz Ortiz
CO
Ramon
Albert M
AM
D000914:Antibodies, Viral; D017209:Apoptosis; D001323:Autoantibodies; D002455:Cell Division; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000276:immunology / Q000473:pathology / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D010865:Pilot Projects; D019349:Roseolovirus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D001323:Autoantibodies