[Effect of 1,2,4-trimethylbenzene inhalation on energy metabolism in experimental animals].
The authors' investigations show that red cells and tissues of animals exposed to a single 4-h inhalation of vapors of 1,2,4-trimethylbenzene in concentration 10 mg/m3 contained reduced amount of ATP, accumulated amounts of ADP, AMP in active inclusion of 32-P in the structure of these compounds. Activation of ATPase is accompanied with a rise of Na and P concentrations and fall in K, Mg and Ca ions concentrations. In blood plasm there were lower levels of Na and Ca and higher levels of K, Mg and P ions. In exposure to ecotoxicant in concentration 0.01-0.1 and 1.0 mg/m3 the changes were insignificant.
Shakirov
D F
DF
Enikeev
D A
DA
D000227:Adenine Nucleotides / Q000097:blood / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000097:blood / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000097:blood / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000097:blood / Q000378:metabolism; D000280:Administration, Inhalation; D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D004734:Energy Metabolism / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D004912:Erythrocytes / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D001555:Benzene Derivatives; D004785:Environmental Pollutants; C010313:pseudocumene; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate