Syndromic incidence of ovarian carcinoma after liver transplantation, with special reference to anteceding breast cancer.
Ovarian cancer is the gynecologic malignancy with the highest number of deaths in the United States. Previous studies had found a decreased incidence of female gynecological malignancies after liver transplantation. In order to estimate the incidence of ovarian carcinoma after liver transplantation, we evaluated 1708 consecutive liver transplant recipients from 1984 to 2001. Of them, 770 (43%) were female. Routine follow-ups were performed at 1, 2, 5, and 10 years after transplantation. There were two cases of ovarian carcinoma. Both occurred in recipients with a previous history of breast cancer. Based on these data, we conclude that the incidence of ovarian cancer is 1:385 among all female liver transplant recipients, and 1:6.5 among those with a history of pretransplant breast cancer. We recommend that regular check-ups should be undertaken, especially in the population at highest risk.
Molmenti
Ernesto P
EP
Baylor University Medical Center, Transplant Services, 3500 Gaston Avenue, Dallas, Texas 75246, USA.
Molmenti
Hebe
H
Weinstein
Jeffrey
J
Elliott
Eric E
EE
Fasola
Carlos G
CG
Orr
Douglas
D
Blum
Joann
J
Savino
Daniel
D
Hamilton
W Mark
WM
Goldstein
Robert M
RM
Levy
Marlon F
MF
Klintmalm
Goran B
GB
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D016031:Liver Transplantation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D013997:Time Factors
D007166:Immunosuppressive Agents