Severe neutropenia with gelatinous bone marrow transformation in anorexia nervosa: a case report.
A 28-year-old woman with a history of anorexia nervosa was admitted with excessive weight loss, edema, and amenorrhea. She had lost 34% of her previous body weight within 2 years, and her body mass index was 12.3 kg/m(2). The leukocyte count on admission was 2150/microl and gradually decreased to 980/microl (neutrophils; 276/microl). Bone marrow biopsy disclosed gelatinous transformation with hypocellularity. After the patient was treated with intravenous nutritional support, the severe neutropenia improved to the level on admission. Hematological abnormalities seem to be common in anorexia nervosa, but severe neutropenia with gelatinous bone marrow transformation has rarely been reported.
Nishio
Shinichiro
S
Department of General Internal Medicine, Seirei Hamamatsu General Hospital, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
Yamada
Hiroshi
H
Yamada
Kaoru
K
Okabe
Hirofumi
H
Okuya
Takafumi
T
Yonekawa
Osamu
O
Ono
Takaaki
T
Sahara
Naohi
N
Tamashima
Sadahiro
S
Ihara
Michio
M
D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D001706:Biopsy; D015992:Body Mass Index; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D009503:Neutropenia / Q000209:etiology* / Q000473:pathology; D015431:Weight Loss