title: [Study of ABO blood group secretor type alpha(1,2)-fucosyltransferase gene polymorphism in Chinese].
abstract: Secretor gene (FUT2)-encoded secretor type alpha(1,2)-fucosyltransferase (Se enzyme) that regulates expression and secretion of ABO(H) antigens in epithelial cell of glands and body fluids. It has the extensive polymorphism and race specificity. In the present study, we investigated the distribution of the fusion gene of the FUT2 locus in 191 Manchu individuals from Liaoning Province and 208 Mongolian individuals from Inner Mongolia, and analyzed the polymorphism of the FUT2 gene in 90 unrelated Han Chinese from Shandong Province and 90 Mongolian from Inner Mongolia, respectively. The fusion gene was not found in the two investigated ethnic groups. The frequencies of G849A nonsense mutation in Shandong Han Chinese and Mongolian of Inner Mongolia individuals were the same, 0.0055.
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Xu-Ming
authors.initials: XM
authors.lastname: Jia
authors.forename: Duan-Yang
authors.initials: DY
authors.lastname: Zhang
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Xuan
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
mesh_terms: D002681:China; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015257:DNA-Cytosine Methylases / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005647:Fucosyltransferases / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D004247:DNA; D015257:DNA-Cytosine Methylases; D015252:Deoxyribonucleases, Type II Site-Specific; D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase; C099067:DNA modification methylase AgeI; C027908:endodeoxyribonuclease DdeI; C040158:GTAC-specific type II deoxyribonucleases