title: [Epidemiologic, clinical and therapeutic aspects of chronic lymphoid leukemia: apropos of 120 cases].
abstract: We retrospectively studied 120 cases of chronic lymphocytic leukemia diagnosed between January 1988 and December 1998. The median age of our patients was of 66 years, 75% among them were male. The discovery of the illness was fortuitous in 20% of the cases, the peripheral adenopathy and the splenomegaly were noted respectively in 72 and 48% of the cases. The blood lymphocytosis was on average 51.109/1 with extremes of 5 and 818.109/1. Anemia was noted in 71% of the cases and a thrombopenia in 42%. Fifty patients were classified C stage of BINET and sixty elevated risk according to RAI. The therapeutic attitude was according to patient's age and the CLL stage. Thus, 94 patients received a chemotherapy and a complete or partial response was observed in 58 of the cases. The overall survival at 5 years were 47%. The retained prognostic factors were the stage according to the classifications of BINET and RAI, the thrombopenia and the lymphocytosis blood overhead 100.109/1.
authors.affiliation: Service d'Hématologie Clinique, CHU Farhat Hached, Sousse, Tunisie.
authors.forename: Mabrouk
authors.initials: M
authors.lastname: Khalifa
authors.forename: Sami
authors.initials: S
authors.lastname: Chehata
authors.forename: Mohamed Adnène
authors.initials: MA
authors.lastname: Laatiri
authors.forename: Chiraz
authors.initials: C
authors.lastname: Grira
authors.forename: Olfa
authors.initials: O
authors.lastname: Gharbi
authors.forename: Mondher
authors.initials: M
authors.lastname: Kortas
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Khelif
authors.forename: S
authors.initials: S
authors.lastname: Ennabli
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents