Gene duplications: the gradual evolution of functional divergence.
Budding yeast provides a useful resource for studies of gene function. A new analysis of the fitness effects of deletion mutations in budding yeast reveals that genes that have duplicates create lower fitness losses when inactivated than do genes that are singletons.
Brookfield
John F Y
JF
Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK.
D000818:Animals; D019143:Evolution, Molecular; D017353:Gene Deletion; D020440:Gene Duplication; D020131:Genes, Duplicate / Q000235:genetics* / Q000502:physiology*; D016681:Genome, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*