Epidermal growth factor receptor: mechanisms of activation and signalling.
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
Jorissen
Robert N
RN
Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.
Walker
Francesca
F
Pouliot
Normand
N
Garrett
Thomas P J
TP
Ward
Colin W
CW
Burgess
Antony W
AW
D000818:Animals; D002465:Cell Movement; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction; D015291:Transforming Growth Factors / Q000378:metabolism
D015291:Transforming Growth Factors; D066246:ErbB Receptors