Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.
Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. In a pilot study to investigate the utility of LOI as a marker of CRC risk, we evaluated 172 patients at a colonoscopy clinic. The adjusted odds ratio for LOI in lymphocytes was 5.15 for patients with a positive family history [95% confidence interval (95% CI), 1.70 to 16.96; probability P = 0.002], 3.46 for patients with adenomas (95% CI, 1.14 to 11.37; P = 0.026), and 21.7 for patients with CRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed with a DNA-based blood test, and it may be a valuable predictive marker of an individual's risk for CRC.
Cui
Hengmi
H
Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Cruz-Correa
Marcia
M
Giardiello
Francis M
FM
Hutcheon
David F
DF
Kafonek
David R
DR
Brandenburg
Sheri
S
Wu
Yiqian
Y
He
Xiaobing
X
Powe
Neil R
NR
Feinberg
Andrew P
AP
D000293:Adolescent; D000375:Aging; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003106:Colon / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes; D008297:Male; D016017:Odds Ratio; D010865:Pilot Projects
D014408:Biomarkers, Tumor; D007335:Insulin-Like Growth Factor II