[Innate and acquired immunity in angiotensin-induced malignant hypertension].
Participation of the immune system in angiotensin (Ang) II-induced endorgan damage is not a conventionally accepted idea. Nevertheless, we have evidence from a double-transgenic rat model of malignant hypertension that Ang II leads not only to activated innate immunity via NF-kB, but also to activated acquired immunity via dendritic cells. By means of surface markers, we observed dendritic cell maturation, migration, and contact with CD4 and CD8 lymphocytes in hearts and kidneys of double-transgenic rats. Treatment with dexamethasone or etanercept provides protection in this model, independent of arterial blood pressure-related effects. Our preliminary data implicate innate immunity and acquired immunity. Both cell-mediated and antibody-mediated effects are involved in the latter in this model.
Luft
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Franz-Volhard-Klinik am Max-Delbrück-Centrum für molekulare Medizin, Medizinische Fakultät der Charité, Humboldt Universität zu Berlin.
D000804:Angiotensin II / Q000009:adverse effects*; D015415:Biomarkers; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D006974:Hypertension, Malignant / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology*; D007113:Immunity, Innate
D015415:Biomarkers; D000804:Angiotensin II