[Phylogenic analysis of the Sox gene family of vertebrate].
Sox genes of vertebrate are highly evolutionarily conserved, which encode different transcriptional factors involved in various developmental processes. Sox family is characterized by a sequence-specific DNA binding HMG-box containing about 79 amino acids. To realize the complexity of genes of the Sox family in the structures, functions and their evolutionary relationships, in the present study by utilizing all available complete nucleotide/protein sequence data of vertebrate Sox genes, we performed multi-sequence comparison and construction of phylogenic tree, and the grouping of Sox family members and the pattern of their molecular evolution was also analyzed.
Wang
Rui
R
Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Cheng
Han-Hua
HH
Guo
Yi-Qing
YQ
Zhou
Rong-Jia
RJ
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D030561:Databases, Nucleic Acid; D019143:Evolution, Molecular; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D010802:Phylogeny; D014157:Transcription Factors / Q000235:genetics; D014714:Vertebrates / Q000235:genetics*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D014157:Transcription Factors