title: Selenium deficiency in a patient with Crohn's disease receiving long-term total parenteral nutrition.
abstract: We report a case of selenium deficiency in a patient with Crohn's disease on long-term total parenteral nutrition (TPN). She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis. Since her plasma selenium level was found to be below the measurable level, we diagnosed this case as selenium deficiency. After intravenous administration of sodium selenite, her symptoms were reversed. Careful attention should be paid to selenium deficiency when a patient receives long-term TPN; supplementary administration of selenium via TPN may be required because selenium is often not routinely added to TPN formulations.
authors.affiliation: Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishida
authors.forename: Katsuro
authors.initials: K
authors.lastname: Himeno
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Torigoe
authors.forename: Megumi
authors.initials: M
authors.lastname: Inoue
authors.forename: Osamu
authors.initials: O
authors.lastname: Wakisaka
authors.forename: Takuo
authors.initials: T
authors.lastname: Tabuki
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Ono
authors.forename: Koichi
authors.initials: K
authors.lastname: Honda
authors.forename: Tetsu
authors.initials: T
authors.lastname: Mori
authors.forename: Masataka
authors.initials: M
authors.lastname: Seike
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
authors.forename: Toshiie
authors.initials: T
authors.lastname: Sakata
mesh_terms: D000328:Adult; D003082:Colectomy / Q000009:adverse effects / Q000379:methods; D003424:Crohn Disease / Q000175:diagnosis* / Q000601:surgery; D003677:Deficiency Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D010288:Parenteral Nutrition / Q000009:adverse effects* / Q000379:methods; D012086:Reoperation; D018570:Risk Assessment; D012643:Selenium / Q000172:deficiency*; D012720:Severity of Illness Index; D012778:Short Bowel Syndrome / Q000209:etiology / Q000628:therapy*; D018038:Sodium Selenite / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012643:Selenium; D018038:Sodium Selenite