title: Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan.
abstract: This study aimed to assess the boundaries of the schizophrenia spectrum and whether inclusion of such phenotypes increases power for linkage analysis of schizophrenia. Participants were 234 first degree relatives (FDRs) of 94 schizophrenia probands in Northern Taiwan who completed a direct interview using the Diagnostic Interview for Genetic Studies (DIGS). Based on best estimate diagnosis, the morbidity risk in the relatives for schizophrenia was 2.5 percent (Weinberg's shorter method) or 3.9 percent (Kaplan-Meier estimate). Depending on the stringency of diagnosis, lifetime prevalence was 2.6 percent to 4.7 percent for schizotypal personality disorder, 3.4 percent to 8.6 percent for paranoid personality disorder, and 1.3 percent to 3.4 percent for schizoid personality disorder. These figures are significantly higher than the corresponding figures in the general population. However, none of the recurrence risk ratio for any spectrum that included both schizophrenia and a personality disorder (3.0 to 5.9) was greater than that of schizophrenia alone (9.3 to 14.4). Thus, including schizophrenia-related personality disorders in the spectrum did not increase power for linkage analysis of schizophrenia.
authors.affiliation: Department of Psychiatry, College of Medicine, National Taiwan University, Taipei.
authors.forename: Ching-Jui
authors.initials: CJ
authors.lastname: Chang
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Shi K
authors.initials: SK
authors.lastname: Liu
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Cheng
authors.forename: Wen-Chen Ou
authors.initials: WC
authors.lastname: Yang
authors.forename: Hung-Jung
authors.initials: HJ
authors.lastname: Chang
authors.forename: Hsien-Yuan
authors.initials: HY
authors.lastname: Lane
authors.forename: Shi-Kwang
authors.initials: SK
authors.lastname: Lin
authors.forename: Tien-Wei
authors.initials: TW
authors.lastname: Yang
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology* / Q000235:genetics*; D008875:Middle Aged; D009017:Morbidity; D010641:Phenotype; D012307:Risk Factors; D012557:Schizoid Personality Disorder / Q000235:genetics* / Q000523:psychology*; D012559:Schizophrenia / Q000150:complications* / Q000235:genetics*; D013624:Taiwan