Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies.
Our observations and those from others, give further support to our hypothesis that "autoimmune aPL" may be generated by immunization with products from bacteria or viruses after incidental exposure or infection. We also were able to generate APS-like syndrome in a strain of mice susceptible to autoimmunity, indicating that other factors such as genetics are likely to be involved in the development of APS. Furthermore, not all aPL antibodies generated by immunization with bacterial or viral products are pathogenic. Based on the clinical experience and on the numerous reports indicating presence of aPL in a large number of infectious diseases, it may be expected that not all aPL antibodies produced during infection will be pathogenic. We hypothesize that a limited number aPL antibodies induced by certain viral/bacterial products would be pathogenic in certain groups of predisposed individuals. Identification of these bacterial and/ or viral agents may help to find strategies for the prevention of production of aPL "pathogenic" antibodies. Alternatively, free peptides may be used to induce tolerance against aPL production.
Gharavi
Azzudin E
AE
Dept. of Medicine, Morehouse School of Medicine, University of Atlanta, Atlanta Georgia 30310-1495, USA. aghara@pol.net
Pierangeli
Silvia S
SS
Harris
E Nigel
EN
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D001665:Binding Sites; D003587:Cytomegalovirus / Q000276:immunology*; D004727:Endothelium / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D008297:Male; D051379:Mice; D010455:Peptides / Q000737:chemistry; D013927:Thrombosis / Q000276:immunology*; D014764:Viral Proteins / Q000378:metabolism; D053482:beta 2-Glycoprotein I
D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D010455:Peptides; D014764:Viral Proteins; D053482:beta 2-Glycoprotein I