title: Adolescents with atopic disorders have an attenuated cortisol response to laboratory stress.
abstract: BACKGROUND
  Patients with allergic disorders have been noted to have variations in cortisol patterns under natural conditions as well as a differential cortisol response to stress.
  
  
  OBJECTIVE
  The main goal of this study was to examine hypothalamic-pituitary-adrenal (HPA) axis differences in atopic adolescents.
  
  
  METHODS
  Subjects were a community sample of 202 adolescents (52% male; mean age, 16.2 years). Atopic status was determined by skin testing and clinical history. Saliva samples for cortisol assay were obtained 4 times during a "typical day" and at 4 time points during laboratory procedures.
  
  
  RESULTS
  One third of the sample (33%) had a clinical atopic disorder, primarily allergic rhinitis; 39% had positive skin test results without clinical symptoms; and 27% had no signs or symptoms of allergic disorders. There were no significant effects of atopic status on home cortisol patterns. Presence of clinical atopy was significantly (P <.05) associated with lower cortisol levels in response to laboratory stressors.
  
  
  CONCLUSIONS
  Adolescents with a history of atopic illnesses had an attenuated cortisol response to the stress of laboratory procedures compared with adolescents with positive skin test results alone or nonatopic adolescents. An attenuated cortisol response to a stressor may help us understand the link between stress and exacerbation of atopic illness.
authors.affiliation: National Jewish Medical and Research Center, Denver, Colo 80206, USA.
authors.forename: Marianne Z
authors.initials: MZ
authors.lastname: Wamboldt
authors.forename: Mark
authors.initials: M
authors.lastname: Laudenslager
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Wamboldt
authors.forename: Kim
authors.initials: K
authors.lastname: Kelsay
authors.forename: John
authors.initials: J
authors.lastname: Hewitt
mesh_terms: D000293:Adolescent; D002648:Child; D019411:Clinical Laboratory Techniques / Q000009:adverse effects*; D005260:Female; D006699:Home Care Services; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006967:Hypersensitivity / Q000175:diagnosis* / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012463:Saliva / Q000378:metabolism*; D012882:Skin Tests; D013048:Specimen Handling; D013312:Stress, Physiological / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D006854:Hydrocortisone