Clinical significance of nuclear matrix-estradiol receptor complex in human sperm.
Estrogen receptor levels were determined in nuclear matrix of human spermatozoa of normospermic fertile men and idiopathic infertile men. In noncapacitated sperm cells, the distribution of the estrogen receptor in normospermic fertile men was present in 50% of the cases, whereas in idiopathic infertile men was present in 19% of the cases. In capacitated sperm cells, the distribution of the estrogen receptor in normospermic fertile men was present in 80% of cases, whereas in idiopathic infertile men was present in 31% of the cases. The values of estrogen receptors in capacitated and noncapacitated sperm cells of normospermic fertile men were 91 +/- 21 and 26 +/- 7 fmol/10(8) sperm cells, respectively, whereas in capacitated and noncapacitated sperm cells of idiopathic infertile men, the estrogen receptor values were 50 +/- 17 and 22.5 +/- 9 fmol/10(8) sperm cells, respectively. The diminution of the estrogen receptor levels in the nuclear matrix could be a biochemical indicator of male factor infertility.
Gonzalez-Unzaga
M
M
Coordinación Investigación en Salud, Instituto Mexicano del Seguro Social, México, DF, México.
Téllez
J
J
Calzada
L
L
D005298:Fertility; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D015530:Nuclear Matrix / Q000378:metabolism*; D011959:Receptors, Estradiol; D013075:Sperm Capacitation; D013094:Spermatozoa / Q000378:metabolism*
D011959:Receptors, Estradiol