Nitric oxide, platelet function, myocardial infarction and reperfusion therapies.
Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.
Alonso
David
D
Department of Integrative Biology and Pharmacology, University of Texas-Houston, 77030, USA.
Radomski
Marek W
MW
D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000628:therapy; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D015425:Myocardial Reperfusion; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000627:therapeutic use
D020030:Nitric Oxide Donors; D009569:Nitric Oxide