Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2.
A Salmonella enterica serotype Cubana isolate exhibiting resistance to most beta-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. beta-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla(KPC-2) with mobile structures.
Miriagou
Vivi
V
Laboratory of Bacteriology, Hellenic Pasteur Institute. Department of Microbiology, Medical School, University of Athens, Athens, Greece.
Tzouvelekis
Leonidas S
LS
Rossiter
Shannon
S
Tzelepi
Eva
E
Angulo
Frederick J
FJ
Whichard
Jean M
JM
D001426:Bacterial Proteins; D001483:Base Sequence; D003001:Cloning, Molecular; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids; D012475:Salmonella / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D015378:Imipenem; D001618:beta-Lactamases; C063912:carbapenemase