title: Distribution of rhodanese in tissues of goat (Capra hircus).
abstract: Rhodanese (thiosulfate: cyanide sulfurtransferase, EC. 2.8.1.1) is a ubiquitous enzyme present in all living organisms, from bacteria to humans and plays a central role in cyanide detoxification. The purpose of this investigation is to determine and compare rhodanese activity in different tissues of adult male and female goats (Capra hircus). The results showed that the specific activity of rhodanese in different tissues was significantly different (P<0.05). The highest activity of rhodanese was in epithelium of rumen, followed by epithelia of reticulum and omasum and liver. No significant difference was observed when tissues of male and female goats were compared. The lowest specific activity of rhodanese was observed in spleen, urinary bladder, lymph node, ovary, skeletal muscle and pyloric muscle of abomasum. The results of this study may indicate the involvement of rhodanese in cyanide detoxification in goat tissues that have greater potential to be exposed to higher levels of cyanide.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran. aminlari@shirazu.ac.ir
authors.forename: Saeed
authors.initials: S
authors.lastname: Nazifi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Aminlari
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Alaibakhsh
mesh_terms: D000818:Animals; D005260:Female; D006041:Goats; D007420:Intestine, Large / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008198:Lymph Nodes / Q000201:enzymology; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology; D009851:Omasum / Q000201:enzymology; D010053:Ovary / Q000201:enzymology; D012159:Reticulum / Q000201:enzymology; D012417:Rumen / Q000201:enzymology; D013154:Spleen / Q000201:enzymology; D013270:Stomach / Q000201:enzymology; D013884:Thiosulfate Sulfurtransferase / Q000378:metabolism*
chemical_list: D013884:Thiosulfate Sulfurtransferase