title: Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.
abstract: Hesperidin (HES) is a flavonoid contained in citrus fruit peel. We investigated the effects of long-term administration of HES and its newly developed water soluble analogue, glucosyl hesperidin (GHES), to spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Animals were fed with diets containing HES or GHES (30 mg/d/kg body weight) for 25 wk. While the daily food intake and the body weight of administered rats were not different from those of the non-administered control rats in both SHR and WKY through the experimental period, the blood pressure and heart rate of SHR administered HES or GHES for longer than 15 wk decreased as compared to the control group. The blood pressure and heart rate of WKY were not changed by the long-term administration of HES or GHES. These results suggest that HES and GHES have anti-hypertensive effects on hypertensive animals.
authors.affiliation: Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700-8530, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Ohtsuki
authors.forename: Asaki
authors.initials: A
authors.lastname: Abe
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mitsuzuwi
authors.forename: Masaru
authors.initials: M
authors.lastname: Kondo
authors.forename: Kanae
authors.initials: K
authors.lastname: Uemura
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kondo
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006569:Hesperidin / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors
chemical_list: D006569:Hesperidin