Activities of ABT-773 against Listeria monocytogenes and coryneform bacteria of clinical interest.
The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria isolated from clinical samples. One hundred percent of the L. monocytogenes strains were inhibited by </=0.015 micro g of ABT-773/ml. MICs of ABT-773 ( micro g/ml) at which 50% of the isolates tested were inhibited (MIC(50)s) and MIC(90)s for other organisms were 0.125 and 0.5 (Corynebacterium amycolatum), 1 and >32 (Corynebacterium jeikeium), 0.03 and >32 (Corynebacterium minutissimum), >32 and >32 (Corynebacterium pseudodiphtheriticum and Corynebacterium urealyticum), 0.125 and >32 (Corynebacterium striatum), and 0.03 and 0.5 (Rhodococcus equi), respectively.
Conejo
María del Carmen
Mdel C
Department of Microbiology, School of Medicine, University of Seville, Seville, Spain.
Martínez-Martínez
Luis
L
Pascual
Alvaro
A
Suárez
Ana Isabel
AI
Perea
Evelio J
EJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin; D003352:Corynebacterium / Q000187:drug effects*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D008089:Listeria monocytogenes / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048628:Ketolides; D002981:Clindamycin; D004917:Erythromycin; C405499:cethromycin