title: Interactions with aromatic rings in chemical and biological recognition.
abstract: Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different approaches-biological studies, molecular recognition studies with artificial receptors, crystallographic database mining, gas-phase studies, and theoretical calculations-are pursued to generate a profound understanding of the structural and energetic parameters of individual recognition modes involving aromatic rings. This review attempts to combine and summarize the knowledge gained from these investigations. The review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.
authors.affiliation: Laboratorium für Organische Chemie, Departement für Chemie und Angewandte Biowissenschaften, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Meyer
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Castellano
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D002412:Cations / Q000737:chemistry / Q000378:metabolism; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000378:metabolism*; D006860:Hydrogen Bonding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D002412:Cations; D006841:Hydrocarbons, Aromatic; D011506:Proteins; D013455:Sulfur