Increase in plasma fibrinogen and plasminogen activator inhibitor level in diabetic KK and KK-Ay mice.
Coagulation activity in KK mice and KK-Ay mice produced by transferring the yellow obese gene (Ay) into KK mice, was studied to examine whether both mice are useful as a model of diabetic atherosclerosis. Plasma levels of hemoglobin A1c (HbA1c), insulin, fibrinogen, plasminogen activator inhibitor (PAI) and thrombomodulin were significantly high in KK and KK-Ay mice compared with age-matched non-diabetic mice (ddY mice). The changes in the plasma levels of fibrinogen at each time-point correlated with the increases in HbA1c levels. Pathological observation by Oil red O staining of aorta tissue from 4-month-old KK and KK-Ay mice revealed the early stages of atherosclerosis such as lipid deposition. These age-related increases in the plasma level of fibrinogen and PAI suggested that KK-Ay mice may contribute to help elucidate the early stages of diabetic atherosclerosis.
Okazaki
Masako
M
Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. okazakim@med.showa-u.ac.jp
Udaka
Yuko
Y
Saito
Yukako
Y
Koseki
Hirohisa
H
Ohta
Sumiko
S
Kikuchi
Takuya
T
Kamiya
Yhuki
Y
Amagasa
Hidetoshi
H
Oguchi
Katsuji
K
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000473:pathology; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D015849:Plasminogen Inactivators / Q000097:blood*; D018180:Thrombomodulin / Q000378:metabolism*
D005340:Fibrinogen; D006442:Glycated Hemoglobin; D007328:Insulin; D015849:Plasminogen Inactivators; D018180:Thrombomodulin