Fibroblast growth factors as regulators of central nervous system development and function.
Fibroblast growth factors (FGFs) are multifunctional signaling proteins that regulate developmental processes and adult physiology. Over the last few years, important progress has been made in understanding the function of FGFs in the embryonic and adult central nervous system. In this review, I will first discuss studies showing that FGF signaling is already required during formation of the neural plate. Next, I will describe how FGF signaling centers control growth and patterning of specific brain structures. Finally, I will focus on the function of FGF signaling in the adult brain and in regulating maintenance and repair of damaged neural tissues.
Dono
Rosanna
R
Faculty of Biology, Department of Developmental Biology, Utrecht University, NL-3584CH Utrecht, The Netherlands. R.Dono@bio.uu.nl
D000375:Aging; D000818:Animals; D019521:Body Patterning; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism
D005346:Fibroblast Growth Factors