Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia.
BACKGROUND
The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy.


METHODS
Patients were randomly assigned to one of three groups. Induction of anesthesia was performed with thiopentone 5 mg kg(-1) in Group I (n = 30), propofol 2 mg kg(-1) in Group II (n = 30), and propofol 3.5 mg kg(-1) in Group III (n = 30). Then succinylcholine 1 mg kg(-1) was administered to the patients for intubation.


RESULTS
Fasciculation was absent in 20% of Group III patients, and no vigorous fasciculation occurred in this group. Furthermore, the severity of fasciculation in Group III was significantly lower than in the other two groups (P = 0.01). Seventy per cent of patients had no myalgia in Group III, 39.2% in Group II and 37% in Group I (P = 0.007). Severity of myalgia was also significantly lower in Group III compared with the other two groups (P = 0.011). Post-operative creatine kinase levels were significantly higher than their baseline values in Groups I and II (P < 0.0001).


CONCLUSIONS
Administration of propofol 3.5 mg kg-1 is effective in reducing fasciculations and myalgia after succinylcholine.
Kararmaz
A
A
Department of Anesthesiology, Dicle University Hospital, Diyarbakir, Turkey. alper@dicle.edu.tr
Kaya
S
S
Turhanoglu
S
S
Ozyilmaz
M A
MA
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D005207:Fasciculation / Q000139:chemically induced* / Q000188:drug therapy*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D010146:Pain / Q000139:chemically induced* / Q000188:drug therapy*; D010149:Postoperative Pain / Q000139:chemically induced* / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013390:Succinylcholine / Q000009:adverse effects*
D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D003402:Creatine Kinase; D013390:Succinylcholine; D015742:Propofol