Effect of magnesium supplementation containing mineral bishofit (MgCl2 x 6H2O) solution and pyridoxine hydrochloride on erythrocyte magnesium depletion and behaviour of rats after three-month alcoholization.
In therapy it is known that the combination of vitamin B6 and magnesium is beneficial in the treatment of several forms of primary magnesium deficiency. The purpose of the present study was to investigate the effect of complex magnesium supplementation containing mineral bishofit solution (MgCl2 x 6H2O) and pyridoxine hydrochloride on behavioural and biochemical parameters of magnesium-deficient alcoholic rats. A complex magnesium supplementation containing mineral bishofit solution and pyridoxine hydrochloride led both to restoration of magnesium level, and to some correction of behavioural disturbances of animals during chronic alcoholization.
Iezhitsa
Igor N
IN
Medical Academy, Research Institute of Pharmacology, 1 Pavshikh Bortsov sq., Volgograd, 400066 Russia. Farm@interdacom.ru
Onishchenko
Natalia V
NV
Churbakova
Natalia V
NV
Parshev
Valentine V
VV
Petrov
Vladimir I
VI
Spasov
Alexander A
AA
D000428:Alcohol Drinking / Q000378:metabolism / Q000523:psychology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003863:Depression / Q000523:psychology; D019587:Dietary Supplements; D004912:Erythrocytes / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology*; D015636:Magnesium Chloride / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D019999:Pharmaceutical Solutions; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002492:Central Nervous System Depressants; D019999:Pharmaceutical Solutions; D015636:Magnesium Chloride; D000431:Ethanol; D008274:Magnesium; D011736:Pyridoxine