[Altered renal function in acute sodium nitrite intoxication experiment].
In experiments on non-inbred albino rats, intoxication was reproduced with 1% aqueous sodium nitrite solution, which was rated by the degree of hemic hypoxia (HH). The findings suggest that changes in renal functions (osmo-regulating, sodium-regulating) occur due to the development of mild HH, by increasing as hypoxia deteriorates. Decreased glomerular filtration and proteinuria, which are concomitantly detected, point to their mixed glomerulotubular pattern of renal lesion in nitrite intoxication.
Gozhenko
A I
AI
Fedoruk
A S
AS
Kotiuzhinskaia
S G
SG
Gozhenko
E A
EA
Kuz'menko
I A
IA
D000818:Animals; D000860:Hypoxia / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D009995:Osmosis / Q000187:drug effects; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D012964:Sodium / Q000378:metabolism; D012977:Sodium Nitrite / Q000633:toxicity*
D012964:Sodium; D012977:Sodium Nitrite