title: Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery.
abstract: Heparin is the standard agent used for systemic anticoagulation during cardiopulmonary bypass in cardiac operations. Alternatives are needed when patients with heparin-induced thrombocytopenia type II are encountered. We present a patient with a clinical picture of heparin-induced thrombocytopenia type II who was effectively anticoagulated with bivalirudin, a direct thrombin inhibitor, during cardiopulmonary bypass for a cardiac operation.
authors.affiliation: Department of Cardiothoracic Surgery, Harper University Hospital, Wayne State University, Detroit, Michigan 48201, USA.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Vasquez
authors.forename: Anna
authors.initials: A
authors.lastname: Vichiendilokkul
authors.forename: Syed
authors.initials: S
authors.lastname: Mahmood
authors.forename: Frank A
authors.initials: FA
authors.lastname: Baciewicz
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000379:methods*; D006493:Heparin / Q000009:adverse effects; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D006493:Heparin; C074619:bivalirudin