title: Influence of hepatitis C virus coinfection on failure of HIV-infected patients receiving highly active antiretroviral therapy to achieve normal serum beta2microglobulin levels.
abstract: The influence of hepatitis C virus (HCV) coinfection on the kinetics of serum beta2microglobulin levels in HIV-infected patients undergoing highly active antiretroviral therapy was analyzed. After 96 weeks of therapy, beta2microglobulin levels declined significantly both in 24 HCV seronegative and 16 HCV-infected individuals. Throughout the follow-up period, HCV-infected patients showed higher beta2microglobulin values than non-HCV-infected patients. These results show that HCV infection precludes immune deactivation in HIV-infected patients undergoing highly active antiretroviral therapy.
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz s/n, 41014, Sevilla, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: García-García
authors.forename: J A
authors.initials: JA
authors.lastname: Mira
authors.forename: J
authors.initials: J
authors.lastname: Fernández-Rivera
authors.forename: A J
authors.initials: AJ
authors.lastname: Ramos
authors.forename: J
authors.initials: J
authors.lastname: Vargas
authors.forename: J
authors.initials: J
authors.lastname: Macías
authors.forename: J A
authors.initials: JA
authors.lastname: Pineda
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D017211:Treatment Failure; D019562:Viral Load / Q000639:trends; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D012367:RNA, Viral; D001613:beta 2-Microglobulin