Genetic heterogeneity of autoimmune disorders in the nonobese diabetic mouse.
The nonobese diabetic mouse is highly susceptible not only to diabetes but to several autoimmune diseases, and one might suspect that these are controlled by a shared set of genes. However, based on various gene-segregation experiments, it seems that only a few loci are shared and that each disorder is influenced also by a unique set of genes.
Johansson
A C M
AC
Section for Medical Inflammation Research, Department of Cell and Molecular Biology, University of Lund, Sweden. asa.johansson@inflam.lu.se
Lindqvist
A-K B
AK
Johannesson
M
M
Holmdahl
R
R
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD / Q000235:genetics* / Q000276:immunology; D040641:Quantitative Trait Loci / Q000276:immunology