Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus.
Roots of Hemidesmus indicus var. indicus are used for various ailments in Indian traditional medicines. The present study evaluated the antiulcerogenic property of aqueous ethanolic extracts of the roots in animal models. Modified pyloric ligated (Shay) rat model and aspirin-induced ulcerogenesis in pylorus ligated rat models were used for this study and analysed for gastric volume, ulcer score, pH, free and total acidity and sodium and potassium ion output. Bio-chemical estimations like total proteins, total hexoses, hexosamine, fucose, sialic acid and pepsin were also made. Ulcer score was calculated for cysteamine-induced duodenal ulcer model. Roots collected during flowering season were found to be more effective than that collected during vegetative seasons.
Anoop
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A
Research and Development, Pharm Products Pvt Ltd, Vijai Medical College Road, Thanjavur 613007, India. anoop_austin@yahoo.com
Jegadeesan
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M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin; D050260:Carbohydrate Metabolism; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control; D000431:Ethanol; D005260:Female; D005643:Fucose / Q000378:metabolism; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism; D031102:Hemidesmus / Q000737:chemistry*; D006595:Hexosamines / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D007194:India; D008026:Ligation; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D006595:Hexosamines; D006601:Hexoses; D010936:Plant Extracts; D011506:Proteins; D005643:Fucose; D000431:Ethanol; D003543:Cysteamine; D012964:Sodium; D010434:Pepsin A; D001241:Aspirin; D011188:Potassium