title: Recent advances in the treatment of leprosy.
abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, was identified by G. H. A. Hansen in 1873. The different clinical presentations of the disease are determined by the quality of the host immune response. The bacteria have affinity for the peripheral nerves and are likely the cause of neuropathy, a cardinal manifestation of the disease. WHO recommends a protocol of multidrug therapy (MDT), which effectively controls the disease, hence contributing to the global elimination program. Early detection of leprosy and treatment by MDT are the most important steps in preventing deformity and disability.
authors.affiliation: Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan. norishii@nih.go.jp
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishii
mesh_terms: D015897:Comorbidity; D003906:Developing Countries; D004334:Drug Administration Schedule; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007918:Leprosy / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D015995:Prevalence
chemical_list: D007917:Leprostatic Agents