Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host.
In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 A/B, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.
Kunstmann
Erdmute
E
Department of Human Genetics, Ruhr-University, Bochum, Germany. Erdmute.Kunstmann@ruhr-uni-bochum.de
Hardt
Cornelia
C
Crabtree
Jean E
JE
Suerbaum
Sebastian
S
Epplen
Jörg T
JT
D000483:Alleles; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D005858:Germany; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D010437:Peptic Ulcer / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D011110:Polymorphism, Genetic
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C080866:cagA protein, Helicobacter pylori