title: A 2,3-butanedione protected chiral glycine equivalent--a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids.
abstract: A new chiral glycine equivalent 7 has been synthesised from glycidol using a chiral memory protocol, and its use in the synthesis of N-Z protected alpha-amino acids was demonstrated in a series of diasteroselective lithium enolate alkylation reactions and subsequent acid hydrolyses.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Harding
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: D Matthew G
authors.initials: DM
authors.lastname: Tilbrook
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis*; D003931:Diacetyl / Q000737:chemistry; D006868:Hydrolysis; D008094:Lithium; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D008094:Lithium; D003931:Diacetyl