title: Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues.
abstract: Twenty-one hydrazides were synthesized by treating different esters with hydrazine hydrate. Substituted hydrazides were obtained by treating hydrazides with alkyl/aryl/acyl halides. Some of these compounds exhibit potential in vitro leishmanicidal activity. The structures of all the synthesized compounds were confirmed by spectroscopic analysis.
authors.affiliation: International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammad
authors.initials: KM
authors.lastname: Khan
authors.forename: Maimona
authors.initials: M
authors.lastname: Rasheed
authors.lastname: Zia-Ullah
authors.forename: Safdar
authors.initials: S
authors.lastname: Hayat
authors.forename: Farhana
authors.initials: F
authors.lastname: Kaukab
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
mesh_terms: D000478:Alkylation; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D018320:Leishmania major / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents
chemical_list: D000981:Antiprotozoal Agents; D006834:Hydrazines; D007202:Indicators and Reagents; D012997:Solvents; C029424:hydrazine