Circular dichroism and the anomeric configuration of C-glycofuranosyl-2-phenyl-2H-1,2,3-triazoles.
Circular dichroism spectra of a series of 4-(tetra-hydroxy-tetryl-1-yl)2-phenyl-2H-1,2,3-triazoles were measured and the sign of their Cotton effects was correlated to the absolute configuration of the hydroxyl group alpha to the triazole base moiety. Those having the D-glycero-configuration in their Fischer projection formula show positive Cotton effect and those with the L-glycero-configuration show negative Cotton effect. This correlation was extended for the assignment of the anomeric configuration of the corresponding glycofuranosyl-C-nucleosides.
Sallam
Mohammed A E
MA
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.