Modifiers of risk of hereditary breast and ovarian cancer.
Hereditary breast and ovarian cancer is among the most commonly encountered adult genetic disease, and it is increasingly important that geneticists, oncologists, surgeons and gynaecologists are aware of the issues regarding risk assessment, prevention and management of women with inherited susceptibility to cancer. Genetic risk can be modified by external factors, but what are these factors, and how might our knowledge of them help us to better define the risks for individual women and to develop strategies for cancer prevention?
Narod
Steven A
SA
Centre for Research on Women's Health, Women's College Hospital, 790 Bay Street, Room 750, University of Toronto, Toronto, Canada M5G 1N8. steven.narod@swchsc.on.ca
D000483:Alleles; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism; D024682:BRCA2 Protein / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D019683:Penetrance; D012307:Risk Factors
D019313:BRCA1 Protein; D024682:BRCA2 Protein