Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n=102) with a group of clinically healthy subjects (n=102), and found that the MI group had a significantly high frequency of 501G/C+501C/C (38.2%) compared with the healthy group (17.6%; p<0.002). The odds ratio for the risk of MI associated with the 501G/C+501C/C genotype was 2.89 (95% CI, 1.51-5.53). These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI. Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.
Tatsuguchi
Mariko
M
The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Furutani
Michiko
M
Hinagata
Jun-ichi
J
Tanaka
Takeshi
T
Furutani
Yoshiyuki
Y
Imamura
Shin-ichiro
S
Kawana
Masatoshi
M
Masaki
Tomoh
T
Kasanuki
Hiroshi
H
Sawamura
Tatsuya
T
Matsuoka
Rumiko
R
D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D009154:Mutation; D020125:Mutation, Missense; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D011973:Receptors, LDL / Q000235:genetics* / Q000378:metabolism*; D051131:Receptors, Oxidized LDL; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D051127:Scavenger Receptors, Class E
C495137:OLR1 protein, human; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E