Immunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally.
Rats were intratracheally (i.t.) exposed to 36.5 or 27.5 microg of cadmium (Cd) as soluble cadmium chloride (CdCl2) and insoluble cadmium oxide (CdO) salts. The retention of metal in lungs, liver and kidney was assessed by atomic adsorption spectrophotometer. The animals were intraperitoneally (i.p.) primed with sheep red blood cells (SRBC) and assessed for the number of antibody forming cells in lung associated lymph nodes (LALN) and spleen. Both the compounds had similar retention of metal in lungs but CdO induced more pulmonary inflammatory and degradative changes than CdCl2. The larger influx of polymorphonuclear cells (PMNs) following CdO exposure appears to be due to the absence of protection afforded by Cd induced metallothionein cytoplasmic protein while the Cd metallothionein complex formed in the case of CdCl2 is more protective. However both forms of Cd had similar local immunosuppressive potential but CdO had more prolonged suppressive effect.
Dogra
Shashi
S
Industrial Toxicology Research Centre, Post Box, No. 80, M.G. Marg, Lucknow 226001, India. itrc@sanchar net.com
Waseem
Mohd
M
Khanna
Ashok Kumar
AK
Kaw
Jawahir Lal
JL
D000818:Animals; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D017610:Calcium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D010087:Oxides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D012995:Solubility; D014132:Trachea
D017610:Calcium Compounds; D007166:Immunosuppressive Agents; D010087:Oxides; C016538:lime; D019256:Cadmium Chloride