[Effects of bisphosphonate on trabecular microstructure].
Bisphosphonate is known to be deposited in resorption area. In our small animal study to evaluate the effect of bisphosphonate on trabecular microstructure, micro-CT demonstrated the different trabecular microstructure among the sham, ovariectomized (OVX) rats and the OVX rats which were treated with risedronate (0.1, 0.5, 2.5 mg/kg) or menatetrenone 30 mg/kg, or with the combination of risedronate 0.5 mg/kg and menatetrenone 30 mg/kg. The pattern of change on trabecular microstructure was also different between risedronate and menatetrenone; risedronate maintained trabecular connectivity, whereas menatetrenone thickened the trabeculae. The combination therapy with menatetrenone provided an additional improvement of trabecular microstructure to the single use of risedronate.
Ito
Masako
M
Department of Radiology, Nagasaki University School of Medicine.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000648:ultrastructure*; D012968:Etidronic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D008852:Microradiography; D051381:Rats; D000068296:Risedronic Acid
D000068296:Risedronic Acid; D012968:Etidronic Acid