Methicillin resistance among isolates of Staphylococcus aureus: antibiotic sensitivity pattern & phage typing.
Out of 3988 clinical specimens from hospital admitted patients 230 strains of Staphylococcus aureus were isolated, 45 strains (19.56%) were Methicillin resistance Staphylococcus aureus (MRSA). All MRSA strains were beta lactamase producers. Multidrug resistance was observed among MRSA strains more commonly than in methicillin sensitive strains of Staphylococcus aureus (MSSA). Maximum strains were resistant to penicillin (100%), co-trimoxa zole (97%) & chloramphenicol (93.33%). As least resistant to gentamicin & ciprofloxacin shown by MRSA, these drugs can be used in few situations after susceptibility test. All strains of MRSA were sensitive to vancomicin (100%). Majority of strains (34 out of 45) showed MIC values of 4 ug/ml. Twenty eight out of 44 strains were non typable using routine phages. Study revealed that MRSA with associated multidrug resistance is common in this region. There is need to develop local set of MRSA phages for improvement of typability.
Tahnkiwale
Supriya S
SS
Department of Microbiology, Indira Gandhi Medical College, Nagpur-440 018
Roy
Soma
S
Jalgaonkar
S V
SV
D001434:Bacteriophage Typing; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007194:India; D007297:Inpatients; D016106:Methicillin Resistance; D015995:Prevalence; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects*; D013492:Suppuration / Q000382:microbiology; D014947:Wounds and Injuries / Q000382:microbiology