Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease.
Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure.
Polidori
M Cristina
MC
Institute of Physiological Chemistry I, Heinrich-Heine University, Düsseldorf, Germany. polidori@uni-duesseldorf.de
Mecocci
Patrizia
P
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D012016:Reference Values
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D008315:Malondialdehyde