title: Positron emission tomographic study of post-ischaemic-hypoxic amnesia.
abstract: BACKGROUND
  Despite extensive research, it still remains controversial as to what the precise location of the critical lesions underlying amnesia actually is. The amnesic syndrome is believed to be heterogeneous and due to several distinct functional deficits.
  
  
  METHODS
  Two patients, a 45-year-old woman and a 56-year-old man, with sudden cardiopulmonary arrest and successful resuscitation, were left with a clear amnesic syndrome as main neurological sequela. During their revalidation period, they underwent a positron emission tomographic (PET) examination, utilizing the (13)NH(3) bolus technique at rest and after intravenous acetazolamide administration.
  
  
  RESULTS
  Both PET studies showed more or less similar features with a decrease in regional cerebral blood flow (rCBF) in the frontal, temporal and parietal lobes. In addition, the rCBF was increased in both thalami of the 45-year-old woman and in the striata of the 56-year-old man. Acetazolamide vasoreactivity was most lost in the frontal lobes.
  
  
  CONCLUSIONS
  In the present PET study, we demonstrated that destruction of the inhibitory pathways to the thalamus and basal ganglia by ischaemic-hypoxic frontal lesions could be one of the mechanisms leading to amnesia.
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium. jacques.dereuck@yucom.be
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.forename: I
authors.initials: I
authors.lastname: Vanwalleghem
authors.forename: D
authors.initials: D
authors.lastname: Hemelsoet
authors.forename: M
authors.initials: M
authors.lastname: De Weweire
authors.forename: K
authors.initials: K
authors.lastname: Strijckmans
authors.forename: I
authors.initials: I
authors.lastname: Lemahieu
mesh_terms: D000086:Acetazolamide; D000647:Amnesia / Q000000981:diagnostic imaging* / Q000209:etiology*; D002545:Brain Ischemia / Q000150:complications*; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000098:blood supply; D013702:Temporal Lobe / Q000098:blood supply; D013788:Thalamus / Q000098:blood supply; D014055:Tomography, Emission-Computed
chemical_list: D000086:Acetazolamide