AMPA blockade may be the mechanism underlying the efficacy of topiramate in PTSD.
Zullino
Danielle F
DF
Krenz
Sonia
S
Besson
Jacques
J
D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use*; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors* / Q000187:drug effects; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000523:psychology; D000077236:Topiramate; D016896:Treatment Outcome
D000927:Anticonvulsants; D018091:Receptors, AMPA; D000077236:Topiramate; D005632:Fructose