[Microdialysis as a procedure for evaluating intestinal hypoxia--an animal experiment approach].
Usual ICU monitoring of patients with abdominal pathology provides no detailed information about hepatosplanchnic haemodynamics or intestinal metabolism. In our animal experiment, the effects of systemic hypoxia on microdialysis measurements of the peritoneum in comparison with the ischiocrural muscle as reference were investigated in 7 rats. The parameter of interest was the course of glucose metabolism reflecting sympathoadrenergic activity during the experiment. Measurements were obtained at timed intervals at baseline, under hypoxia, and during reoxygenation. After induction of systemic hypoxia, the peritoneal microdialysis showed significantly higher levels of glucose in comparison with the ischiocrural muscle. The results indicate hypermetabolic activity or a hypersympathetic response of the bowel in response to hypoxic stress. In the clinical setting, the bowel has an important role in the development of multiorgan failure. Microdialysis may therefore be an interesting tool for the early detection of hypoxic metabolism during and after abdominal procedures.
Bahlmann
L
L
Klinik für Anästhesiologie, Universitätsklinikum Lübeck.
Markert
U
U
Wirtz
Ch
Ch
Heringlake
M
M
Eichler
W
W
Schmucker
P
P
Klaus
S
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D000860:Hypoxia / Q000175:diagnosis / Q000503:physiopathology*; D007422:Intestines / Q000098:blood supply* / Q000294:innervation; D008297:Male; D017551:Microdialysis; D008991:Monitoring, Physiologic; D018482:Muscle, Skeletal / Q000098:blood supply; D010101:Oxygen Consumption / Q000502:physiology; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology
D001786:Blood Glucose