title: Activation of brown adipose tissue thermogenesis increases slow wave sleep in rat.
abstract: Considering the thermoregulatory role of slow wave sleep (SWS), we wondered whether the sole increase of brown adipose tissue (BAT) thermogenesis could enhance this sleep state. We tested this hypothesis by administering to rats an agonist (BRL 37,344) of the beta-3 adrenoceptor subtype that is massively localized in BAT cell membrane and that is known to activate BAT thermogenesis. Sleep was electrographically characterized. The temperature of interscapular BAT (Tibat) and cortex (Tco) were also assessed. Tibat significantly increased 2-3 h after BRL injection (but not Tco), concomitantly with SWS (+56-57%). At the maximum of Tibat, a significant positive correlation was found between their changes and those of SWS. We demonstrated for the first time that sleep (and especially SWS) can be affected by the specific activation of BAT.
authors.affiliation: Faculty of Medicine of Amiens, ETPAPC, 3 rue des louvels, 80036 Amiens Cedex, France. gerard.dewasmes@sa.u-picardie.fr
authors.forename: G
authors.initials: G
authors.lastname: Dewasmes
authors.forename: N
authors.initials: N
authors.lastname: Loos
authors.forename: S
authors.initials: S
authors.lastname: Delanaud
authors.forename: D
authors.initials: D
authors.lastname: Dewasmes
authors.forename: A
authors.initials: A
authors.lastname: Géloën
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D022722:Thermogenesis / Q000187:drug effects / Q000502:physiology*
chemical_list: D004983:Ethanolamines; C057368:BRL 37344