title: [Colonic stenosis secondary to non-steroid anti-inflammatory agents as a cause of anemia and chronic diarrhea].
abstract: Gastroduodenal mucosal injury is a widely recognized side effect of non-steroidal antiinflammatory agents (NSAID). Distal small bowel and colon are additional organs of the gastrointestinal tract exposed to deleterious effects of these drugs. Inflammation and ulceration have been described as pathologic damage associated with NSAID. Strictures of colon induced by NSAID are a new entity characterized by diaphragm-like strictures. Most patients present with anemia, obstructive symptoms, diarrhea, or weight loss. Endoscopic dilation, surgical resection, symptomatic treatment, and interruption of NSAID ingestion are treatment of choice. Only 23 cases of NSAID-related, colonic, diaphragm-like strictures have been reported. Here we describe a case of concentric colonic stricture related to naproxen and clinical features of this entity are discussed.
authors.affiliation: Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga # 15, Col. Sección XVI, CP 14000, Tlalpan DF. chemaremes@hotmail.com
authors.forename: José María
authors.initials: JM
authors.lastname: Remes-Troche
authors.forename: Karina
authors.initials: K
authors.lastname: Contreras-Zurita
authors.forename: Nina Paola
authors.initials: NP
authors.lastname: Ríos-Luna
authors.forename: Manuel
authors.initials: M
authors.lastname: Sierra-Ascencio
authors.forename: Angel Miguel
authors.initials: AM
authors.lastname: Valdovinos
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002908:Chronic Disease; D003108:Colonic Diseases / Q000139:chemically induced* / Q000150:complications; D003251:Constriction, Pathologic / Q000139:chemically induced; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000150:complications; D009288:Naproxen / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen