Fragile sites: breaking up over a slowdown.
Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.
Cimprich
Karlene A
KA
Stanford University, Department of Molecular Pharmacology, Stanford, CA 94305-5174, USA. cimprich@stanford.edu
D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D002873:Chromosome Fragility; D004247:DNA / Q000096:biosynthesis* / Q000378:metabolism*; D004261:DNA Replication; D006801:Humans; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004247:DNA; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases