[Amoebic liver abscess. Study of 20 cases with literature review].
OBJECTIVE
The management of amoebic liver abscess includes antiamoebic drugs combined or not with percutaneous puncture or surgical drainage. This study was to suggest a decision tree for the therapeutic approach of such feature.


METHODS
We report a retrospective analysis of 20 imported cases with amoebic liver abscesses admitted at the Department of Tropical Diseases during 1995-1999 at the Bordeaux University Hospital Centre, France, and a review of the literature.


RESULTS
The twenty patients were 14 males and 6 females, mainly 20 to 40 years old. The clinical presentation was mainly accounting a painful liver enlargement with hyperthermia. The echographic picture was mostly represented by a unique liver element located at the liver right lobe. They were numerous in an HIV infected patient. Thirteen patients have been treated using a medical therapeutic approach. A percutaneous puncture has been necessary for 4 cases. A percutaneous drainage has been realised for two patients as regard to the persistence of the hepatalgia occurrence. A surgical drainage has been experienced by two patients after a lack of efficacy of a percutaneous drainage, after rupture of an abscess treated medically, respectively. A review of the literature and the analysis of the 20 cases history have been used to determine a therapeutic algorithm.


CONCLUSIONS
The occurrence of immediate complications at onset must indicate a first line surgical drainage procedure. Beside this situation, risk factors for rupture must be assessed (high size abscess, pejorative localization), as well as poor prognosis feature (liver failure, bacteraemia). If no pejorative condition occurs, a first-line exclusive medical approach can be undertaken with a clinical efficacy evaluation at H72. Otherwise, the indication of the percutaneous drainage must be discussed.
Djossou
F
F
Fédération de médecine interne, maladies infectieuses et tropicales, hôpital Saint-André, 1, rue Jean-Burguet, 33075 cedex, Bordeaux, France. djossou@wanadoo.fr <djossou@wanadoo.fr>
Malvy
D
D
Tamboura
M
M
Beylot
J
J
Lamouliatte
H
H
Longy-Boursier
M
M
Le Bras
M
M
D000328:Adult; D000818:Animals; D000994:Antitrichomonal Agents / Q000627:therapeutic use; D003663:Decision Trees; D004322:Drainage; D005260:Female; D006801:Humans; D008101:Liver Abscess, Amebic / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
D000994:Antitrichomonal Agents; D008795:Metronidazole