[Interactive pathway of ARF-mdm2-p53].
The inhibitor of cyclin-dependent kinase 4-p16INK4 alpha and its alterative reading frame (ARF)-INK4/ARF gene locates at CDKN2A locus of human chromosome 9p21. This locus encodes two overlapped genes: ARF gene and p16INK4 alpha. The amino acid sequences of two genes are completely different because they are encoded by alternative reading frames. ARF participates in the regulation of mdm2-p53 pathway by mdm2. Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene. Here is a review of ARF-mdm2-p53 interacting pathway.
Lin
Jing
J
Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, P.R. China.
Zhu
Ming-Hua
MH
D017398:Alternative Splicing; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D019941:Cyclin-Dependent Kinase Inhibitor p16; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2