[Latest aspects in psoriasis pathogenesis].
During recent years the understanding of psoriasis pathogenesis has changed essentially. Psoriasis is now considered as a T cell mediated inflammation of the skin. Genetic predisposition and microbial environment cooperate in the induction of an antigen-specific T cell mediated immune response which may persist lifelong. The phenotype of the psoriatic inflammation is determined by the particular functional differentiation of the pathogenic T cells. The progress in understanding the pathogenesis of psoriasis has identified T cells and T cell-derived cytokines as targets for causal treatment approaches that in the near future will change psoriasis therapy considerably.
Prinz
J C
JC
Klinik und Poliklinik für Dermatologie und Allergologie der LMU München, Munich. joerg.prinz@lrz.uni-muenchen.de
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D015603:Keratinocytes / Q000276:immunology; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D012867:Skin / Q000276:immunology; D017192:Skin Diseases, Bacterial / Q000235:genetics / Q000276:immunology; D013290:Streptococcal Infections / Q000235:genetics / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology