Cyclocarbopalladation: formation of bicyclic 1,2-cyclobutanediols through a rare 4-exo-dig cyclization.
[reaction: see text] Several bicyclic compounds bearing a strained 1,2-cyclobutanediol have been prepared from a gamma-bromopropargylic diol under palladium(0) catalysis. The reaction proceeds through a rare unfavored 4-exo-dig cyclocarbopalladation. In some cases, the first reaction is followed by a 6pi-electrocyclization leading to unusual strained tricyclic systems.
Salem
Bahaâ
B
Université Louis Pasteur de Strasbourg (UMR 7081 CNRS/ULP), Faculté de Pharmacie, 74, route du Rhin, 67401 Illkirch-Cedex, France.
Klotz
Philippe
P
Suffert
Jean
J