Correlations among behavioral measures of orbitofrontal function.
Orbitofrontal cortex plays an important role in guiding behavior based on emotional input and rewards. It receives multimodal higher order sensory information and mediates reinforcement for primary as well as secondary or conditioned forms of reinforcement (e.g., monetary rewards). Several behavioral measures have demonstrated putative sensitivity to orbitofrontal function: smell identification, delayed alternation, and response inhibition (go/no-go and antisaccades). A correlational study of performances on these tasks by healthy controls demonstrated some interrelationships: go/no-go correlated with antisaccades, left nostril smell correlated with go/no-go, and right nostril smell correlated with delayed alternation. Further analysis showed that certain smells correlated with tasks more strongly than others. Given the diversity of these tasks, it is suggested that these intercorrelations results from at least the partial overlap of the neural substrates for olfactory identification and tasks requiring response modification based on reinforcement contingencies.
Spinella
Marcello
M
Division of Social and Behavioral Sciences, Richard Stockton College of New Jersey, P.O. Box 195, Pomona, NJ 08240-0195, USA. marcello.spinella@stockton.edu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000679:Amygdala / Q000502:physiology; D001479:Basal Ganglia / Q000502:physiology; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D020645:Mediodorsal Thalamic Nucleus / Q000502:physiology; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology*; D011594:Psychometrics; D011897:Random Allocation; D012438:Saccades / Q000502:physiology; D012903:Smell / Q000502:physiology