title: The active caspase-8 heterotetramer is formed at the CD95 DISC.
authors.forename: I
authors.initials: I
authors.lastname: Lavrik
authors.forename: A
authors.initials: A
authors.lastname: Krueger
authors.forename: I
authors.initials: I
authors.lastname: Schmitz
authors.forename: S
authors.initials: S
authors.lastname: Baumann
authors.forename: H
authors.initials: H
authors.lastname: Weyd
authors.forename: P H
authors.initials: PH
authors.lastname: Krammer
authors.forename: S
authors.initials: S
authors.lastname: Kirchhoff
mesh_terms: D000906:Antibodies; D017209:Apoptosis / Q000502:physiology*; D001402:B-Lymphocytes / Q000201:enzymology*; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004792:Enzyme Precursors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D021122:Protein Subunits / Q000276:immunology / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014407:Tumor Cells, Cultured; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D000906:Antibodies; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004791:Enzyme Inhibitors; D004792:Enzyme Precursors; D046911:Macromolecular Substances; D021122:Protein Subunits; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; C505407:CASP3 protein, human; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases