title: Integrated approaches to therapeutic target gene discovery.
abstract: The identification of tractable drug targets is the first critical step in the long process of drug development, and the challenge for scientists in the post-genomic era is to couple gene and protein sequence information with biological insight to identify genes with the greatest therapeutic and commercial potential. An extraordinary array of genomics- and proteomics-based techniques is available for this endeavor, and combining multiple, complementary approaches enhances the informative power of such experimentation.
authors.affiliation: Immusol Inc, 10790 Roselle Street, San Diego, CA 92121, USA.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: DeFife
authors.forename: Flossie
authors.initials: F
authors.lastname: Wong-Staal
mesh_terms: D000818:Animals; D015870:Gene Expression; D020868:Gene Silencing; D018390:Gene Targeting / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D005826:Genetics, Medical / Q000379:methods*; D023281:Genomics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D040081:Protein Array Analysis; D040901:Proteomics