title: Effects of orthotopic liver transplantation on vasoactive systems and renal function in patients with advanced liver cirrhosis.
abstract: The effects of Orthotopic liver transplantation (OLT) on renal function and major vasoactive factors was assessed in end-stage cirrhotic patients. Renal function, mean arterial pressure, and plasma vasoactive hormones were measured In 22 cirrhotic patients with refractory ascites before and after OLT. Before OLT, mean arterial pressure, glomerular filtration rate, free water clearance, and fractional sodium excretion serum sodium levels were decreased. In addition, serum creatinine and plasma levels of vasoactive factors were increased. Ten of these patients fulfilled criteria of hepatorenal syndrome (HRS). Nine to 12 months after transplantation, renal function had improved and plasma levels of vasoactive factors had decreased significantly in all patients, including those with HRS. However, glomerular filtration rate remained subnormal and plasma endothelin-1 levels and plasma renin activity remained increased in most of them. In conclusion, OLT improves renal function in patients with end-stage liver cirrhosis, including those with HRS. However, renal function remains subnormal in most of these patients.
authors.affiliation: Department of Gastroenterology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
authors.forename: Concepcíon
authors.initials: C
authors.lastname: Cassinello
authors.forename: Enrique
authors.initials: E
authors.lastname: Moreno
authors.forename: Adolfo
authors.initials: A
authors.lastname: Gozalo
authors.forename: Blanca
authors.initials: B
authors.lastname: Ortuño
authors.forename: Beatriz
authors.initials: B
authors.lastname: Cuenca
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Solís-Herruzo
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006530:Hepatorenal Syndrome / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000503:physiopathology* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors; D014661:Vasoconstriction / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*