Angiomatosis of the breast in a male child. A case report with immunohistochemical analysis.
Angiomatosis is a benign vascular lesion that has been described rarely in the breast. We describe a case in a seven-year-old boy of African descent who presented with progressively increasing, unilateral breast enlargement, the first such report in a male child. The patient underwent excisional biopsy of the breast mass followed by mastectomy. Pathologic examination revealed a diffuse proliferation of variably-sized, thin-walled vascular channels lined by flattened endothelium that showed negative immunohistochemical staining for von Willebrand factor, factor VIII-related antigen, CD34 and S-100 protein. There is no evidence of recurrence after 24 months of follow-up.
Shirley
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SE
Departments of Pathology and Surgery, Radiology, Anaesthesia and Intensive Care, University of the West Indies, Kingston 7, Jamaica.
Duncan
N D
ND
Escoffery
C T
CT
West
A B
AB
D000798:Angiomatosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001941:Breast Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015414:Mastectomy, Subcutaneous