title: The multiple tumor syndrome. Personal experience.
abstract: The multiple tumor syndrome is an unusual pathologic condition, which consists in association of multiple malignancies in the same patient. Seven cases are discussed: two women, five men, aged 32-70 years. The period between the two neoplasias was 2-23 years (in 6 cases). In one case the two malignancies appeared concomitantly. The hematological malignancies were: multiple myeloma: 2 cases; chronic granulocytic leukemia: 2 cases; chronic lymphatic leukemia: 3 cases. In four cases, the solid tumor followed the hematological malignancy at variable periods (2 and 4 years). In other two cases, the solid tumors preceded the hematological malignancy with 2 years, 23 years respectively. The solid tumors were genital cancers, malignant melanoma, spino-cellular carcinoma, thyroid cancer, hemangiosarcoma. In a single case the second tumor was a hematological malignancy too (NHL-diffuse lymphocytic lymphoma). Possible implications of previous therapy and environmental factors are discussed.
authors.affiliation: School of Medicine, Department of Clinical Hematology, University Hospital Sf. Spiridon, University of Medicine and Pharmacy, Gr.T. Popa, Iaşi.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Hanganu
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000628:therapy; D005134:Eye Neoplasms / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy