title: Expression of the LIM proteins paxillin and Hic-5 in human tissues.
abstract: The LIM domain is a protein-protein interaction motif critically involved in a variety of fundamental biological processes, including cytoskeletal organization, cell lineage specification, and organ development. In this study we examined the expression of the LIM proteins paxillin and Hic-5 in adult human tissues by immunohistochemistry and immunoblotting. Paxillin expression was widespread and observed both in non-muscle and muscle tissues. Of the latter, paxillin was mainly expressed in multinuclear striated muscle. In contrast, Hic-5 showed restricted expression and was expressed in muscle tissues, mainly in mononuclear smooth muscle. Taken together with previous findings, it appears likely that the counterbalance between paxillin and Hic-5 may be deeply involved in muscle differentiation.
authors.affiliation: Department of Clinical Laboratory, Yamanashi Medical University, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yuminamochi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yatomi
authors.forename: Makoto
authors.initials: M
authors.lastname: Osada
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ohmori
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishii
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Shigemi
authors.initials: S
authors.lastname: Hosogaya
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009928:Organ Specificity; D051419:Paxillin; D010750:Phosphoproteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D016212:Transforming Growth Factor beta