[Hypersensitiviy to Trichophyton rubrum antigens in atopic and non-atopic podiatrists].
BACKGROUND
Podiatrists as well as manicurists are exposed to inhale nail dust contaminated with mycotic particles when filing and burring the onychomycotic nails of their patients. As some of them with atopic background suffered worsening of their symptoms we decided to study the immune response to the fungus Trichophyton rubrum (Tr) that was isolated from the nail dust obtained from the podiatrists office.


RESULTS
A detailed clinical record, intracutaneous skin tests with a extract of Tr and the serum levels of total and specific IgE were performed in rhinitis-asthma as well as control patients. As the asthmatic group refused to perform the challenge bronchial test with Tr we developed a guinea pig experimental model with daily aerosolization of Tr during 12 weeks studying the levels of specific IgE and IgG as well as the lung's histopathology. Atopic patients showed positive immediate skin tests with Tr and both groups revealed delayed hypersensitivity to the antigen.RAST-IgE-anti-Tr and RAST-inhibition confirmed the specificity of the antibodies. Guinea pigs also synthetized IgG and IgE anti-Tr and suffered different degrees of lung lesions similar to those of hypersensitivity pneumonitis.


CONCLUSIONS
Atopic podiatrists are exposed to fungal allergens that may participate or aggravate their previous respiratory conditions.
Alonso
A
A
Centro de Alergia, Hospital de Clínicas. Facultad de Medicina. Buenos Aires. Argentina. alehclin@fmed.uba.ar
Pionetti
C H
CH
Mouchián
K
K
Albónico
J F
JF
Irañeta
S G
SG
Potenza
M
M
Iovannitti
C
C
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D000542:Alveolitis, Extrinsic Allergic / Q000209:etiology* / Q000276:immunology; D000818:Animals; D000946:Antigens, Fungal / Q000009:adverse effects* / Q000276:immunology; D001249:Asthma / Q000209:etiology / Q000276:immunology; D004391:Dust; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D009262:Nails / Q000382:microbiology; D009784:Occupational Diseases / Q000209:etiology* / Q000276:immunology; D016273:Occupational Exposure; D010323:Passive Cutaneous Anaphylaxis; D011032:Podiatry; D011863:Radioimmunoassay; D012882:Skin Tests; D014249:Trichophyton / Q000276:immunology*
D000395:Air Pollutants, Occupational; D000946:Antigens, Fungal; D004391:Dust; D007074:Immunoglobulin G; D007073:Immunoglobulin E