title: An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins.
abstract: CFEM, an eight cysteine-containing domain, has been identified by analyzing over 25 fungal sequences selected from database sequence searches. Features of CFEM suggest that it is a novel domain with characteristics distinct from known cysteine-rich domains. Some CFEM-containing proteins (e.g. Pth11 from Magnaporthe grisea) are proposed to have important roles in fungal pathogenesis.
authors.affiliation: Fungal Genomics Laboratory, Center for Integrated Fungal Research, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Resham D
authors.initials: RD
authors.lastname: Kulkarni
authors.forename: Hemant S
authors.initials: HS
authors.lastname: Kelkar
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Dean
mesh_terms: D000595:Amino Acid Sequence; D003545:Cysteine / Q000737:chemistry* / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry* / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D005656:Fungal Proteins; D008565:Membrane Proteins; D010940:Plant Proteins; D003545:Cysteine