title: Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist.
abstract: The separation and biological evaluation of rotamers as well as interconversion studies on rotamers of our clinical candidate SCH 351125 are described.
authors.affiliation: Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com
authors.forename: Anandan
authors.initials: A
authors.lastname: Palani
authors.forename: Sherry
authors.initials: S
authors.lastname: Shapiro
authors.forename: John W
authors.initials: JW
authors.lastname: Clader
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
authors.forename: David
authors.initials: D
authors.lastname: Blythin
authors.forename: Kathleen
authors.initials: K
authors.lastname: Cox
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Wagner
authors.forename: Julie
authors.initials: J
authors.lastname: Strizki
authors.forename: Bahige M
authors.initials: BM
authors.lastname: Baroudy
authors.forename: Niya
authors.initials: N
authors.lastname: Dan
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D001682:Biological Availability; D065100:CCR5 Receptor Antagonists; D018946:Chemokine CCL5 / Q000037:antagonists & inhibitors; D002851:Chromatography, High Pressure Liquid; D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007536:Isomerism; D010091:Oximes; D010880:Piperidines; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D065100:CCR5 Receptor Antagonists; D018946:Chemokine CCL5; D003497:Cyclic N-Oxides; D010091:Oximes; D010880:Piperidines; D011725:Pyridines; C438583:Ancriviroc