Ion-extraction ladder sequencing from bead-based libraries.
Ion-extraction mass spectrometry of ladders of mixtures of isotopically labeled compounds from single beads allows the unambiguous sequencing of bead-based peptides and offers significant advantages over traditional methods of library analysis.
Pastor
Jose J
JJ
Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès, 1-11, 08028 Barcelona, Spain.
Lingard
Iain
I
Bhalay
Gurdip
G
Bradley
Mark
M
D016000:Cluster Analysis; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D019151:Peptide Library; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D007202:Indicators and Reagents; D019151:Peptide Library