title: The lipoprotein lipase Ser447Ter mutation and risk of stroke in the Chinese.
abstract: BACKGROUND
  Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism. The Ser447Ter mutation of LPL may be associated with ischemic cerebrovascular diseases. We investigated whether the LPL variants were related to risk of strokes in Chinese Hans.
  
  
  METHODS
  We recruited 160 patients with cerebrovascular diseases (ischemic stroke, n=96; hemorrhagic stroke, n=64) and 117 age-matched controls. All subjects were Chinese Hans. Subjects were analyzed for the Ser447Ter mutation by restriction fragment length polymorphisms of the LPL gene.
  
  
  RESULTS
  As compared with controls, the frequency of LPL genotype CG (heterozygous Ser447Ter mutation) was lower in ischemic stroke patients (10.4% vs. 21.4%, p<0.05), and was not significantly different in hemorrhagic stroke patients (15.6% vs. 21.4%, p>0.05). The LPL G allele frequency was also lower in ischemic stroke patients (5.2%) vs. controls (10.7%, p<0.05). There was no difference between hemorrhagic stroke patients (7.8%) and controls. Serum Lp(a) concentrations were markedly lower in CG carriers than that in CC carriers in both stroke patients and the controls (p<0.05). There was no significant difference in the concentrations of other lipids.
  
  
  CONCLUSIONS
  Patients with ischemic stroke have a lower frequency of the LPL Ser447Ter mutation, which indicates that this mutation may have protective effect on ischemic stroke.
authors.affiliation: Department of Cardiology, Second Xiangya Hospital of Central South University, Changsha 410011, PR China. zhaosp@cs.hn.cn
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: Zhao
authors.forename: Qi-Guang
authors.initials: QG
authors.lastname: Tong
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Xiao
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Cheng
authors.forename: Hong-Nian
authors.initials: HN
authors.lastname: Zhou
authors.forename: Shai
authors.initials: S
authors.lastname: Nie
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology
chemical_list: D008055:Lipids; D008071:Lipoprotein Lipase