Apoptosis in hematological disorders.
Apoptosis, the cell's intrinsic death program, plays a critical role in the regulation of tissue homeostasis, especially in cell systems with a high turnover rate such as hematopoietic cells. Imbalances between proliferation and cell death may result in premature death, uncontrolled polyclonal or monoclonal expansion or tumor formation. Also, cytotoxic therapy and immunotherapy of leukemia and lymphoma predominantly mediates cell death through induction of apoptosis. Understanding the molecular events by which tumor cells evade apoptotic deletion and which induce apoptosis by cytotoxic therapies, have provided a paradigm to link normal growth control, malignant transformation and response to therapy.
Debatin
Klaus Michael
KM
University Children's Hospital, Prittwitzstr. 43, 89075 Ulm, Germany. klaus-michael.debatin@medizin.uni-ulm.de
Stahnke
Karsten
K
Fulda
Simone
S
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D006402:Hematologic Diseases / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D019014:fas Receptor / Q000502:physiology
D019014:fas Receptor