title: Pleural effusion caused by prostaglandin E1 preparation.
abstract: We encountered a case of bilateral pleural effusion associated with prostaglandin E(1) (PGE(1)) preparation. A 75-year-old man underwent replacement surgery for an amputated hand. PGE(1) was administered at 120 micro g/d to maintain circulation after vascularization. From day 7 of administration, respiratory distress developed. On day 12, pleural effusion was observed bilaterally. By discontinuing PGE(1) and improving hypoalbuminemia, pleural effusion resolved rapidly. This is the first case report of PGE(1)-induced pleural effusion; like other drug-induced pleural effusions, discontinuing the drug resulted in rapid improvement. Although a rare complication, pleural effusion has to be suspected when a patient receiving PGE(1) experiences difficulty with breathing.
authors.affiliation: Department of Orthopedic Surgery, Yamanashi Medical University, Japan. Hiroshiw123@hotmail.com
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Anayama
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sato
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishihara
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000009:adverse effects*; D006801:Humans; D034141:Hypoalbuminemia / Q000209:etiology; D008297:Male; D008866:Microsurgery; D010996:Pleural Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000139:chemically induced / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil