Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia.
It has been suggested that gene aberrations may contribute to vascular endothelial dysfunction of pre-eclampsia in Caucasian and Japanese women. This study was undertaken to examine the association between pre-eclampsia in Black Zulu speaking South African women and the Factor 5 Leiden mutation. 100 patients with pre-eclampsia comprised the study group. The control group comprised 110 normotensive pregnant women of the same population group. Genotyping was performed to detect the G or A allele at residue 506 of the Factor V gene, and the C or T allele at residue 455 of the thrombomodulin gene. Our findings demonstrate that these particularly genetic loci are of little use in disease association studies for pre-eclampsia in homogenous Zulu speaking Africans.
Hira
B
B
MRC/UN Pregnancy Hypertension Research Unit, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
Pegoraro
R J
RJ
Rom
L
L
Moodley
J
J
D000293:Adolescent; D000328:Adult; D020137:Base Pair Mismatch / Q000235:genetics; D044383:Black People / Q000235:genetics*; D004461:Eclampsia / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005166:Factor V Deficiency / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D005838:Genotype; D006801:Humans; D009154:Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics*; D013019:South Africa / Q000208:ethnology; D018180:Thrombomodulin / Q000235:genetics*
D018180:Thrombomodulin; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin