Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.
Hesperidin (HES) is a flavonoid contained in citrus fruit peel. We investigated the effects of long-term administration of HES and its newly developed water soluble analogue, glucosyl hesperidin (GHES), to spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Animals were fed with diets containing HES or GHES (30 mg/d/kg body weight) for 25 wk. While the daily food intake and the body weight of administered rats were not different from those of the non-administered control rats in both SHR and WKY through the experimental period, the blood pressure and heart rate of SHR administered HES or GHES for longer than 15 wk decreased as compared to the control group. The blood pressure and heart rate of WKY were not changed by the long-term administration of HES or GHES. These results suggest that HES and GHES have anti-hypertensive effects on hypertensive animals.
Ohtsuki
Kazumasa
K
Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700-8530, Japan.
Abe
Asaki
A
Mitsuzuwi
Hitoshi
H
Kondo
Masaru
M
Uemura
Kanae
K
Iwasaki
Yumiko
Y
Kondo
Yasuhiro
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006569:Hesperidin / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors
D006569:Hesperidin