title: Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities.
abstract: Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.
authors.affiliation: Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. ssjew@plaza.snu.ac.kr
authors.forename: Sang-sup
authors.initials: SS
authors.lastname: Jew
authors.forename: Boon-saeng
authors.initials: BS
authors.lastname: Park
authors.forename: Doo-yeon
authors.initials: DY
authors.lastname: Lim
authors.forename: Myoung Goo
authors.initials: MG
authors.lastname: Kim
authors.forename: In Kwon
authors.initials: IK
authors.lastname: Chung
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Chung Il
authors.initials: CI
authors.lastname: Hong
authors.forename: Joon-Kyum
authors.initials: JK
authors.lastname: Kim
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Jun-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyeung-geun
authors.initials: HG
authors.lastname: Park
mesh_terms: D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D019098:Telomerase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D011725:Pyridines; D019098:Telomerase