A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles.
In this note, we report a study of cryoprotectant carbohydrate (glucose, fructose, mannose and maltose) effects on the reconstitution of calixarene based solid lipid nanoparticle (SLN) suspensions after freeze-drying, studied by atomic force microscopy and photon correlation spectroscopy. All carbohydrates tested showed excellent cryoprotection and redispersion properties with the calixarene based SLNs.
Shahgaldian
Patrick
P
Institut de Biologie et Chimie des Protéines, Lyon, France. p.shahgaldian@ibcp.fr
Gualbert
Jérôme
J
Aïssa
Kaïs
K
Coleman
Anthony W
AW
D015502:Absorptiometry, Photon; D047250:Calixarenes; D003451:Cryoprotective Agents / Q000737:chemistry; D004339:Drug Compounding; D005612:Freeze Drying / Q000379:methods; D005632:Fructose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D010316:Particle Size; D011083:Polycyclic Compounds / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D013535:Suspensions
D003451:Cryoprotective Agents; D008055:Lipids; D011083:Polycyclic Compounds; D013535:Suspensions; D047250:Calixarenes; D005632:Fructose; D005947:Glucose; D007785:Lactose; D008358:Mannose