Eudesmane derivatives and other constituents from Saussurea parviflora.
A survey of the whole plant of Saussurea parviflora afforded three compounds 11,12,13-trihydroxy-4(15),8-eudesmadiene-9-one, eudesman-8beta,12-olide-1-O-beta-D-glucoside and 1beta,3beta-dihydroxyursa-9(11),12-diene-3-octadecanoate, as well as 13 known compounds. Their structures were elucidated on the basis of spectral evidence, especially by using NMR spectroscopic techniques. In addition, encelin exhibited effective antitumor activity on L02, SMMC-7721 and HO-8910 cells.
Yang
Zhong-Duo
ZD
National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Gao
Kun
K
Jia
Zhong-Jian
ZJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010946:Plants, Medicinal / Q000737:chemistry; D030441:Saussurea / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane