Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature.
Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possible after immunohistochemical investigations of the expression of specific tumour markers but electron microscopic observations help to clarify most of these diagnoses.
Marioni
Gino
G
Department of Otolaryngology-Head and Neck Surgery, University of Padua, Padua, Italy. g_marioni@virgilio.it
Bottin
Raffaele
R
Staffieri
Alberto
A
Altavilla
Giuseppe
G
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology; D007890:Leiomyosarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D012086:Reoperation
D014408:Biomarkers, Tumor