Proposal of a haemorheological profile for early detection of hypertensive gestational disorders.
The objective of this study was to emphasise the potential power of simple and inexpensive haemorheological tests as predictors of hypertensive gestational disorders through a retrospective study. Blood samples of 195 primigravids with gestational age 18-23 weeks were studied. For data processing pregnant women were allocated into 3 groups, based on difference of SBP and DBP values measured at first and last consultation, and presence of proteinuria and oedema: Normotensive pregnants (n=149), hypertensive pregnants; n=26 and preeclamptic pregnants; n=20. Whole blood viscosity, plasma viscosity, erythrocyte rigidity and aggregability, haemoglobin, hematocrit, total protein, albumin and fibrinogen were assayed. Increased relative viscosity (eta(r)) (p<0.01), decreased erythrocyte deformability (p<0.05), lower O(2) release (p<0.01) and birth weight (p<0.01), showed a negative correlation with filterability index in preeclamptics. There was a decrease of erythrocyte deformability in hypertensive women. Erythrocyte deformability and blood viscosity could be an early indicator in preeclamptics, and erythrocyte deformability in hypertensive ones, therefore they could be considered alert factors in order to decide a thorough control in these patients to prevent further complications.
Bollini
A
A
Departmento de Ciencias Fisiológicas, Biofísica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina. abollini@hotmail.com
Hernández
G
G
Bravo Luna
M
M
Cinara
L
L
Rasia
M
M
D001724:Birth Weight; D001809:Blood Viscosity; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D020073:Gravidity; D006403:Hematologic Tests; D018056:Hemorheology; D006801:Humans; D006973:Hypertension / Q000097:blood*; D010100:Oxygen / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
D010100:Oxygen