title: Surgical therapy in Hashimoto's thyroiditis.
abstract: Hashimoto's thyroiditis (HT) is usually considered to be manageable by levothyroxine (L-T4) administration, which can reduce the thyroid volume and supplement the lack of hormone. However, we sometimes encounter a huge goiter that has not shrunk in response to L-T4 therapy. These goiters continue to produce symptoms of compression and an unsightly appearance. Here we discuss the surgical indication and procedure for HT. Thirteen patients with clinically diagnosed Hashimoto's thyroiditis involving a huge diffuse goiter that produced pressure symptoms or nodular lesions were treated with surgery. The gender, age distribution, total dose and period of L-T4 administration prior to the operation, and clinical symptoms caused by the large goiter were evaluated in each case. The titer of antibodies was extremely elevated in 8 HT patients with a diffusely enlarged goiter. The total period of L-T4 medication ranged from 6 to 25 years. A subtotal thyroidectomy in which a small amount of thyroid was left in the posterior area of the bilateral lobes was performed in the 8 cases of diffusely enlarged goiter. Pressure symptoms and the unsightly appearance caused by the goiter were relieved by the surgery in all cases. No surgical complications developed. In conclusion, the surgery is an effective therapy for HT patients who have persistent compression symptoms and/or an unsightly neck appearance due to a large goiter despite long-term L-T4 treatment.
authors.affiliation: Department of Surgery II, Nippon Medical School, Tokyo, Japan. kshimizu@nms.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shimizu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Wataru
authors.initials: W
authors.lastname: Kitagawa
authors.forename: Haruki
authors.initials: H
authors.lastname: Akasu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takatsu
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Ishii
authors.forename: Shigeo
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D013967:Thyroiditis, Autoimmune / Q000601:surgery*; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013974:Thyroxine