title: Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.
abstract: Seizures are an uncommon but serious complication of hyponatremia which can lead to permanent brain damage and even death. It is recommended that patients with hyponatremic-induced seizures be treated with 3% hypertonic saline, however, a rapid rate of correction may result in central pontine myelinolysis (CPM), a severe neurological disorder characterized by mutism, dysarthria, spastic quadriparesis, and pseudobulbar palsy. The patient in this case developed a hyponatremia-induced generalized tonic-clonic seizure which was aborted by rapid therapy with diazepam, followed by hypertonic saline and phenytoin. Subsequent replacement of hypertonic saline with normal saline and salt tabs in combination with phenytoin allowed gradual correction of serum sodium without any subsequent seizures or neurological complications.
authors.forename: Kristi S M
authors.initials: KS
authors.lastname: Youn
authors.forename: Jinichi
authors.initials: J
authors.lastname: Tokeshi
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000188:drug therapy*; D010672:Phenytoin / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D012462:Saline Solution, Hypertonic; D010672:Phenytoin; D003975:Diazepam