Three-year prospective randomized study of incidence of posterior capsule opacification in eyes treated with topical diclofenac and betamethasone.
OBJECTIVE
To investigate the incidence of posterior capsule opacification (PCO) in eyes treated with diclofenac sodium (DFNa) and betamethasone phosphate (BMS) ophthalmic solutions.


METHODS
A total of 200 eyes with silicone intraocular lens implantation were treated with topical agents for 3 months postoperatively. Twenty-six cases of the DFNa group and 34 of the BMS group met the criteria, and the severity of PCO was evaluated after 3 years.


RESULTS
The results of axial densitometry by Scheimpflug photography were 27.8 computer-compatible tapes (CCT) in the DFNa-treated group and 32.6 CCT in the BMS-treated group (p = 0.1539). Posterior capsulotomy was performed in 11.5% of the DFNa group and 17.6% of the BMS group (p = 0.8375). The photographic grading of PCO showed no difference.


CONCLUSIONS
The incidence of PCO in eyes treated with DFNa appears to be equal to that after BMS treatment.
Tsuchiya
Tadaharu
T
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Yokohama, Japan.
Ayaki
Masahiko
M
Onishi
Takeo
T
Kageyama
Toshiyuki
T
Yaguchi
Shigeo
S
D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001623:Betamethasone / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular / Q000009:adverse effects / Q000379:methods; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology; D019591:Pseudophakia / Q000150:complications; D012826:Silicone Elastomers / Q000009:adverse effects; D016037:Single-Blind Method; D014792:Visual Acuity / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012826:Silicone Elastomers; D004008:Diclofenac; D001623:Betamethasone