Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo).
Extracts from 11 plant species belonging to the Zingiberaceae were tested for antifungal activity using disc diffusion bioassays. Extracts from several members, especially Alpinia galanga, Curcuma zedoaria and Zingiber purpureum, were found to have pronounced inhibitory activities against a wide variety of human pathogenic fungi, including strains resistant to the common antifungals amphotericin B and ketoconazole. As members of the Zingiberaceae are generally regarded as safe for human consumption, these species are excellent candidates for development as novel therapeutics.
Ficker
Christine E
CE
Department of Biology, Carleton University, 1125 Colonel By Drive, Ont., K1S 5B6, Ottawa, Canada.
Smith
Myron L
ML
Susiarti
Siti
S
Leaman
Danna J
DJ
Irawati
C
C
Arnason
John T
JT
D000935:Antifungal Agents / Q000494:pharmacology*; D001893:Borneo; D025141:Drug Resistance, Fungal; D019448:Ethnobotany; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D010936:Plant Extracts / Q000494:pharmacology; D030521:Zingiberaceae / Q000737:chemistry*
D000935:Antifungal Agents; D010936:Plant Extracts