SSRIs antidepressant activity is influenced by G beta 3 variants.
The aim of the present study was to test a possible effect of the G-protein beta3-subunit (Gbeta3) C825T gene variant on the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) in a sample of major and bipolar depressives, with or without psychotic features. Four hundred and ninety inpatients were treated with fluvoxamine 300 mg/day (n=362) or paroxetine 40 mg/day (n=128) and either placebo or pindolol in a double-blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. Gbeta3 allelic variants were determined in each subject using a PCR-based technique. Subjects with Gbeta3 T/T variants showed better response to treatment (P=0.009) and this effect was independent from analyzed demographic and clinical variables. These results confirm preliminary reports and shed further light on the genetics of the response to antidepressant treatments.
Serretti
Alessandro
A
Department of Psychiatry, Vita-Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy. serretti.alesandro@hsr.it
Lorenzi
Cristina
C
Cusin
Cristina
C
Zanardi
Raffaella
R
Lattuada
Enrico
E
Rossini
David
D
Lilli
Roberta
R
Pirovano
Adele
A
Catalano
Marco
M
Smeraldi
Enrico
E
D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000187:drug effects / Q000502:physiology*; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
D000928:Antidepressive Agents; D020962:Heterotrimeric GTP-Binding Proteins; D021122:Protein Subunits; D017367:Selective Serotonin Reuptake Inhibitors; C454420:G-protein beta3 subunit