title: Do micrometastases detected with cytokeratin immunoperoxidase reactivity affect the treatment approach to neck in supraglottic cancers?
abstract: OBJECTIVE
  The aim of this study was to determine the occult lymph node metastasis rates with immunoperoxidase staining for cytokeratin in supraglottic larynx cancers and to assess our approach to the neck.
  
  
  METHODS
  Twenty-two patients who had squamous cell carcinoma in the supraglottic region and no histopathologic metastasis in the neck who had their cancer detected with the use of hematoxylin-eosin were included in the study. All of the specimens were reevaluated with the use of immunoperoxidase staining for cytokeratin.
  
  
  RESULTS
  Micrometastatic disease (pN1) has been detected in 3 patients (13.61%) in whom no metastasis was detected with routine histopathologic examination.
  
  
  CONCLUSIONS
  Results suggest that the occult metastasis rates are higher than those detected with routine hematoxylin-eosin staining. However, because it is accepted that neck dissection alone has adequate therapeutic efficiency in pN1 patients, the detected 13.61% rate of micrometastases has not changed our treatment plan in the neck.
authors.affiliation: Department of II Otorhinolaryngology-Head and Neck Surgery, Social Security Organization, Ankara Education Hospital, Turkey. sinankocaturk@yahoo.com
authors.forename: Sinan
authors.initials: S
authors.lastname: Kocatürk
authors.forename: Demet
authors.initials: D
authors.lastname: Yilmazer
authors.forename: Binnur
authors.initials: B
authors.lastname: Onal
authors.forename: Unsal
authors.initials: U
authors.lastname: Erkam
authors.forename: Bilge
authors.initials: B
authors.lastname: Urünal
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D004801:Eosine Yellowish-(YS) / Q000378:metabolism; D005456:Fluorescent Dyes / Q000378:metabolism; D005931:Glottis; D006416:Hematoxylin / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*
chemical_list: D005456:Fluorescent Dyes; D007633:Keratins; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin