title: Voluntary discontinuance of seven years successful insulin prophylaxis produced shortly overt diabetes in a first-degree relative of a diabetic child at high risk for type 1 diabetes.
abstract: This is the story of a nondiabetic first-degree relative of a child with Type 1 Diabetes who was screened for Type 1 diabetes and was found to be at high risk being positive for genetic, immunologic and metabolic markers. He accepted to be treated with low-dose subcutaneous insulin and for 7 years he has been living in subclinical prediabetes state. At the beginning of eighth year, he voluntary discontinued the preventive insulin therapy and after 18 months clinically overt diabetes appeared.
authors.affiliation: Department of Pediatrics, Chair of Pediatrics, Regional Centre for Children and Adolescents with Diabetes, University of Parma, Parma, Italy. vanelli@unipr.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vanelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Chiari
authors.forename: Tommaso
authors.initials: T
authors.lastname: Giacalone
authors.forename: Barbara
authors.initials: B
authors.lastname: Adinolfi
authors.forename: Angomeh
authors.initials: A
authors.lastname: Ndongko
authors.forename: Annachiara
authors.initials: A
authors.lastname: Casadei
mesh_terms: D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics* / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin