Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge.
A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.
Pettit
George R
GR
Cancer Research Institute, Arizona State University, PO Box 872404, Tempe, AZ 85287-2404, USA. bpettit@asu.edu
Tan
Rui
R
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D002849:Chromatography, Gas; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C478752:phakellistatin 12