Recurrent cholestasis due to ampicillin.
OBJECTIVE
To present a single case of ampicillin-induced recurrent cholestasis and a literature review.


METHODS
A 23-year-old man was hospitalized due to recurrent and self-limited cholestatic symptoms. He had used ampicillin before each cholestatic attack. He became well clinically and biochemically each time after cessation of the drug. One year after his recovery and discontinuance of ampicillin, the patient has had no recurrence of cholestasis. An objective causality assessment revealed that the adverse drug reaction was probable.


CONCLUSIONS
Ampicillin-related hepatotoxicity is very rare, with injury being mainly hepatocellular. To our knowledge, there is only 1 case report in the literature referring to chronic cholestatic-type hepatotoxicity related to ampicillin.


CONCLUSIONS
Ampicillin, which is one of the most widely used antibiotics, may cause recurrent cholestatic hepatitis. Clinicians should be aware of this adverse effect, and it should be kept in mind during diagnostic workup of liver injury.
Köklü
Seyfettin
S
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. gskoklu@yahoo.com
Yüksel
Osman
O
Filik
Levent
L
Usküdar
Oguz
O
Altundag
Kadri
K
Altiparmak
Emin
E
D000328:Adult; D000667:Ampicillin / Q000009:adverse effects*; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects*; D012008:Recurrence
D010406:Penicillins; D000667:Ampicillin