[Morphological changes in smooth myocytes of cerebral arteries in experimental hypertension and after its elimination].
Using cytological, histochemical and morphometric methods, the changes of leiomyocytes of cerebral arteries was studied in 55 pups with experimental hypertension induced by coarctation of the aorta and in 15 animals following reversal of coarctation as compared to the normal characteristics of these cells established in 15 control dogs. It was established that hypertension induced hypertrophy and polyploidy of leimoyocytes of the circular muscular layer in the tunica media of the cerebral arteries, that was manifested as the increase in their nuclear DNA content and in the numbers of binuclear cells. After the elimination of hypertension, which was previously established in the cerebral vasculature, the tendency for the reversal of the changes in nuclear and cytoplasmic linear parameters of the cells examined was observed. However, the nuclear DNA content and the number of polyploid leiomyocytes in the cerebral arteries remained practically unchanged. The latter indicates that the polyploidy of leiomyocytes in the cerebral arteries is irreversible.
Ial'tsev
A V
AV
Department of Operative Surgery and Topographical Anatomy, Department of Pathologic Anatomy, Yaroslavl State Medical Academy.
D000818:Animals; D001017:Aortic Coarctation / Q000150:complications / Q000473:pathology; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D003592:Cytophotometry; D004195:Disease Models, Animal; D004285:Dogs; D006973:Hypertension / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D020768:Middle Cerebral Artery / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000473:pathology*