title: Arylamine N-acetyltransferase-2 genotypes in the Thai population.
abstract: OBJECTIVE
  To determine the frequencies of the major arylamine- N-acetyltransferase-2 (NAT2) alleles in the Thai population.
  
  
  METHODS
  DNA samples from 235 Thai individuals were analysed by polymerase chain reaction with restriction fragment length polymorphism assays.
  
  
  RESULTS
  The frequency distribution of major NAT2 alleles, including NAT2*4, NAT2*5, NAT2*6 and NAT2*7 were 0.381 (95% CI 0.337, 0.426), 0.038 (0.023, 0.060), 0.326 (0.283, 0.370) and 0.204 (0.169, 0.244), respectively. When converted to phenotypes, the study population comprised 63.8% rapid acetylators and 36.2% slow acetylators.
  
  
  CONCLUSIONS
  The pattern of NAT2 alleles of Thais is similar to those of many Asian populations, although the frequency of NAT2*4 is significantly lower and NAT2*7 is higher than that of Oriental populations.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Thailand, 40002. veerapol@kku.ac.th
authors.forename: Veerapol
authors.initials: V
authors.lastname: Kukongviriyapan
authors.forename: Auemduan
authors.initials: A
authors.lastname: Prawan
authors.forename: Wichittra
authors.initials: W
authors.lastname: Tassaneyakul
authors.forename: Jareerat
authors.initials: J
authors.lastname: Aiemsa-Ard
authors.forename: Benjamart
authors.initials: B
authors.lastname: Warasiha
mesh_terms: D000107:Acetylation; D000328:Adult; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D013785:Thailand / Q000208:ethnology
chemical_list: D001191:Arylamine N-Acetyltransferase