title: Combined effects of dietary conjugated linoleic acid and sesamin triacylglycerol and ketone body production in rat liver.
abstract: The effects of a combination of dietary conjugated linoleic acid (CLA) supplemented with sesamin on hepatic ketogenesis and triacylglycerol secretion were compared using the livers of rats fed diets containing 1% CLA or linoleic acid (LA) in combination with 0.2% sesamin for 14 d, respectively. The feeding of CLA, as compared to LA, caused a significant reduction in the weight of perirenal adipose tissue but not that of epididymal adipose tissue, and affected neither growth parameters nor hepatic lipid concentration. Hepatic production of ketone bodies was consistently higher in rats fed CLA than in those fed LA, while triacylglycerol secretion was reversed. No significant difference was noted in the hepatic secretion of cholesterol among the groups. Although there was no effect of the dietary combination of CLA with sesamin on adipose tissue weight, hepatic lipid parameters and ketone body production were observed: i.e., triacylglycerol secretion tended to be reduced. These results suggest that the dietary combination of CLA with sesamin may be an effective approach for lowering serum triacylglycerol levels. The decreased hepatic secretion of triacylglycerol is, in part, due to enhanced fatty acid oxidation in the liver.
authors.affiliation: Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889-2192, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Sakono
authors.forename: Kumiko
authors.initials: K
authors.lastname: Yuji
authors.forename: Fumiko
authors.initials: F
authors.lastname: Miyanaga
authors.forename: Shizuka
authors.initials: S
authors.lastname: Tamaru
authors.forename: Michiko
authors.initials: M
authors.lastname: Fujita
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fukuda
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Toshio
authors.initials: T
authors.lastname: Iwata
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kasai
authors.forename: Michihiro
authors.initials: M
authors.lastname: Sugano
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D004032:Diet; D004149:Dioxoles / Q000494:pharmacology*; D007657:Ketone Bodies / Q000096:biosynthesis*; D017705:Lignans / Q000494:pharmacology*; D019787:Linoleic Acid / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014280:Triglycerides / Q000096:biosynthesis*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000924:Anticholesteremic Agents; D004149:Dioxoles; D007657:Ketone Bodies; D017705:Lignans; D014280:Triglycerides; D019787:Linoleic Acid; C054125:sesamin