title: An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease.
abstract: Recent studies have demonstrated that p53-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls. This polymorphism has been intensively investigated for association with cancer, but so far not with AD and neurodegeneration. We found no association between this locus and the risk for AD. No association was detected also for the age at disease onset and for disease progression, and no interactive effect was found with apolipoprotein E e4. These findings show no evidence for an association between p53 codon 72 polymorphism and AD in our population.
authors.affiliation: Department of Neurology, Hadassah University Hospital, Ein Karem, Jerusalem 91120, Israel. rosenman@hadassah.org.il
authors.forename: Hanna
authors.initials: H
authors.lastname: Rosenmann
authors.forename: Zeev
authors.initials: Z
authors.lastname: Meiner
authors.forename: Esther
authors.initials: E
authors.lastname: Kahana
authors.forename: Zoja
authors.initials: Z
authors.lastname: Aladjem
authors.forename: Gideon
authors.initials: G
authors.lastname: Friedman
authors.forename: Arie
authors.initials: A
authors.lastname: Ben-Yehuda
authors.forename: Tal
authors.initials: T
authors.lastname: Grenader
authors.forename: Eli
authors.initials: E
authors.lastname: Wertman
authors.forename: Oded
authors.initials: O
authors.lastname: Abramsky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D017209:Apoptosis / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D003062:Codon