In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species.
The in vitro anti-influenza virus effects of some isoquinoline alkaloids, isolated from Thalictrum species (Ranunculaceae), growing in Mongolia and Sweden have been studied. (-)-thalimonine (Thl) and (-)-thalimonine N-oxide, isolated from the Mongolian plant T. simplex, inhibited markedly the influenza virus reproduction in vitro; thalictuberine N-oxide was less effective. The synthetic analogues of Thl as well as the rest of the tested alkaloids, isolated from T. foetidum and T. flavum, were not active. At a concentration range between 0.1 - 6.4 microM Thl inhibited viral reproduction in a selective and specific way.
Serkedjieva
Julia
J
Velcheva
Maria
M
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009975:Orthomyxoviridae / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031949:Thalictrum
D000470:Alkaloids; D000998:Antiviral Agents; D007546:Isoquinolines; D010936:Plant Extracts