Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice.
Quantitative trait locus (QTL) analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels at 10 weeks of age was performed in 321 F2 offspring from SM/J and A/J mice. Interval mapping revealed a total of 22 suggestive QTLs affecting the four traits: two insulin QTLs on Chromosomes (Chrs) 6 and 8; six triglyceride QTLs on Chrs 4, 8, 9, 11, 12 and 19; six total-cholesterol QTLs on Chrs 1, 3, 4, 14, 17 and 19; and eight phospholipid QTLs on Chrs 2, 3, 4, 6, 8, 10 and 19. Gender influenced the expression of eight of the suggestive QTLs. The total-cholesterol QTLs on Chrs 4, 14 and 17, the triglyceride QTL on Chr 9 and the phospholipid QTL on Chr 4 were specific to females. The phospholipid QTLs on Chrs 2 and 6 and the insulin QTL on Chr 8 were specific to males. In addition, common QTLs involved in the regulation of some of the traits were identified. The female-specific QTL on Chr 4 appeared to be involved in the regulation of total cholesterol and phospholipid levels. The QTL on Chr 8 affected insulin and phospholipid levels, whereas the Chr 19 QTL was common to the three lipid parameters.
Anunciado
Rea Victoria P
RV
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8601, Japan.
Nishimura
Masahiko
M
Mori
Masayuki
M
Ishikawa
Akira
A
Tanaka
Shin
S
Horio
Fumihiko
F
Ohno
Tamio
T
Namikawa
Takao
T
D000818:Animals; D002784:Cholesterol / Q000097:blood* / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D007328:Insulin / Q000097:blood* / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood* / Q000235:genetics*; D010743:Phospholipids / Q000097:blood* / Q000235:genetics*; D040641:Quantitative Trait Loci; D012723:Sex
D007328:Insulin; D010743:Phospholipids; D002784:Cholesterol