Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice.
Several studies reported that peripheral administration of bombesin (BN) and gastrin-releasing peptide (GRP) improved some forms of memory performance. In the present study, we examined the role of endogenous BN-like peptide(s) for the acquisition of inhibitory avoidance learning in mice using BN-like peptide receptor antagonists. An administration of [Leu(13)-(psi-CH(2)NH)-Leu(14)]BN (antagonizes GRP-R>neuromedin B receptor (NMB-R)) impaired the performance of inhibitory avoidance learning in all doses (16, 32, 64 nmol/kg). While the effect was somewhat lesser than [Leu(13)-(psi-CH(2)NH)-Leu(14)]BN, BIM23127 (antagonizes NMB-R>GRP-R) also impaired performance in a moderate dose (32 nmol/kg). These results showed that endogenous BN-like peptides have some role(s) for the modulation of learning and memory, and suggest that NMB/NMB-R pathway may also be involved in the memory acquisition and modulation as well as GRP/GRP-R pathway.
Santo-Yamada
Yuko
Y
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira-City, Tokyo 187-8502, Japan.
Yamada
Kazuyuki
K
Wada
Etsuko
E
Goto
Yu-ichi
Y
Wada
Keiji
K
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003624:Darkness; D005260:Female; D008029:Lighting; D051379:Mice; D008810:Mice, Inbred C57BL; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D018004:Receptors, Bombesin / Q000037:antagonists & inhibitors* / Q000502:physiology*
C092829:BIM 23127; D010456:Peptides, Cyclic; D018004:Receptors, Bombesin