Protective effect of Rhodiola sachalinensis extract on carbon tetrachloride-induced liver injury in rats.
This study was carried out to investigate the protective effect of an aqueous extract from the root of Rhodiola sachalinensis (RSE) on liver injury induced by repetitive administration of carbon tetrachloride in rats. RSE was given orally to rats at doses of 50, 100 or 200 mg/kg throughout the carbon tetrachloride treatment for 28 days. In rats treated with carbon tetrachloride, the levels of hydroxyproline and malondialdehyde (MDA) in the liver, and serum enzyme activities were significantly increased. RSE treatment significantly reduced the levels of liver hydroxyproline and MDA, and serum enzyme activities, in accordance with improved histological findings. Immunohistological findings indicated RSE treatment inhibited hepatic stellate cell activation, which is a major step for collagen accumulation during liver injury. These data suggest that RSE protects the liver from repetitive injury induced by carbon tetrachloride in rats.
Nan
Ji-Xing
JX
Department of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Jiang
Ying-Zi
YZ
Park
Eun-Jeon
EJ
Ko
Geonil
G
Kim
Youn-Chul
YC
Sohn
Dong Hwan
DH
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D006909:Hydroxyproline / Q000378:metabolism; D007150:Immunohistochemistry; D007202:Indicators and Reagents; D007723:Korea; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola / Q000737:chemistry*
D007202:Indicators and Reagents; D010936:Plant Extracts; D008315:Malondialdehyde; D006909:Hydroxyproline