Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy.
The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20-24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.
Tietze
Lutz F
LF
Institut für Organische Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. ltietze@gwdg.de
Griesbach
Ulrich
U
Schuberth
Ingrid
I
Bothe
Ulrich
U
Marra
Alberto
A
Dondoni
Alessandro
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016754:Boron Neutron Capture Therapy; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents; D006027:Glycosides