[Susceptibility of enterococci to natural and synthetic iron chelators].
A total of 79 strains of enterococci belonging to 10 species were tested for susceptibility to natural and synthetic iron chelators. All strains produced siderophores. These enterococci were susceptible to three synthetic iron chelators only: 8-hydroxyquinoline, disodium versenate (EDTA) and o-phenanthroline. They were resistant to all other synthetic chelators: ethylenediamine-di(o-hydroxyphenylacetic acid) (EDDHA), nitrilotriacetate, 2,2'-bipiridyl, salicylic acid, 8-hydroxy-5-sulphonic acid and to all natural chelators: ovotransferrine, human apotransferrine, horse apoferritine, desferrioxamine B, ferrichrome and rhodotorulic acid. The relations between susceptibility/resistance, iron assimilation and structure and stability constants of iron chelators were discussed.
Lisiecki
Paweł
P
Zakład Mikrobiologii Farmaceutycznej, Katedra Mikrobiologii AM w Łodzi.
Mikucki
Jerzy
J
D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D017262:Siderophores / Q000096:biosynthesis; D013045:Species Specificity
D007502:Iron Chelating Agents; D017262:Siderophores