Integrin alpha v, c-erbB2 and DNA ploidy in lung metastases from colorectal cancer.
OBJECTIVE
We analyzed integrin alpha v and c-erbB2 expression and DNA ploidy in primary tumors and pulmonary metastases from colorectal carcinoma.


METHODS
Fifty primary tumors and 21 lung metastases were examined for immunohistochemical detection of integrin alpha v, c-erbB2 and DNA ploidy.


RESULTS
In integrin alpha v-positive tumors, integrin alpha v was strongly recognized in the cytoplasm of colorectal carcinoma. In total cases, in a multivariate model using logistic stepwise regression analysis, venous invasion was significantly and independently related to lung metastasis in patients who underwent curative resection. Integrin alpha v, c-erbB2 and DNA ploidy in primary tumors were not predictable for lung metastasis. On the other hand, in the 21 patients with lung metastases, integrin alpha v overexpression was identified in 52.4% (11/21) of primary tumors and in 85.7% (18/21) of lung metastases, respectively. The positive ratio was significantly higher in lung metastases than in primary tumors (p < 0.05). There was no significant difference between primary tumors and lung metastases in DNA ploidy or c-erbB2 expression.


CONCLUSIONS
Integrin alpha v might be one of the important signals for formation of lung metastases from colorectal cancer as a late event.
Sato
Takahiro
T
Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan. Ytakahiro.sato@jfer.or.jp
Konishi
Koji
K
Maeda
Kiichi
K
Yabushita
Kazuhisa
K
Miwa
Atsuo
A
D000230:Adenocarcinoma / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D039564:Integrin alphaV / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies
D039564:Integrin alphaV