title: Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: a case successfully treated with melatonin.
abstract: The prognosis of patients with idiopathic thrombocytopenic purpura refractory to corticosteroids and splenectomy (refractory ITP) is poor; these patients present high morbidity from disease and its treatment and have a mortality rate of approximately 16%. A patient is reported with severe bleeding symptoms related to refractory ITP successfully treated with melatonin.
authors.affiliation: Local Health Department of National Health Service, Fermo, Italy. todmau@tin.it
authors.forename: Mauro
authors.initials: M
authors.lastname: Todisco
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Casaccia
authors.forename: Nazzareno
authors.initials: N
authors.lastname: Rossi
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004438:Ecchymosis / Q000209:etiology; D004844:Epistaxis / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008550:Melatonin / Q000627:therapeutic use*; D011693:Purpura / Q000209:etiology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D012720:Severity of Illness Index; D013156:Splenectomy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D008550:Melatonin