title: Neurofilaments and neurological disease.
abstract: Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post-translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.
authors.affiliation: Departments of Neuroscience and Neurology, Institute of Psychiatry, King's College London, London SE5 8AF, UK. ammar@iop.kcl.ac.uk
authors.forename: Ammar
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: Christopher C J
authors.initials: CC
authors.lastname: Miller
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016900:Neurofilament Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D021122:Protein Subunits / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000235:genetics; D000072105:Superoxide Dismutase-1; D016875:tau Proteins / Q000235:genetics
chemical_list: D016900:Neurofilament Proteins; D021122:Protein Subunits; C000606290:SOD1 protein, human; D016875:tau Proteins; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1