Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia.
Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats.
Ballero
M
M
Dipartimento di Scienze Botaniche, viale San Ignazio 13, Cagliari 09123, Italy. ballero@unica.it
Loi
M C
MC
van Rozendaal
E L M
EL
van Beek
T A
TA
van de Haar
Cees
C
Poli
F
F
Appendino
G
G
D000470:Alkaloids / Q000737:chemistry; D000531:Altitude; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007558:Italy; D017239:Paclitaxel / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves; D012987:Soil; D043823:Taxoids / Q000737:chemistry; D020946:Taxus
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012987:Soil; D043823:Taxoids; C047703:taxine; C073950:baccatin III; D017239:Paclitaxel