title: Translational regulation of the plant S-adenosylmethionine decarboxylase.
abstract: It is becoming apparent that control of protein synthesis by metabolites is more common than previously thought. Much of that control is exerted at the level of initiation of mRNA translation, orchestrated by upstream open reading frames (uORFs) and RNA secondary structure. S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis and both mammalian and plant AdoMetDCs are translationally regulated by uORFs in response to polyamine levels by distinct mechanisms.
authors.affiliation: Division of Food Safety Science, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K.
authors.forename: C
authors.initials: C
authors.lastname: Hanfrey
authors.forename: M
authors.initials: M
authors.lastname: Franceschetti
authors.forename: M J
authors.initials: MJ
authors.lastname: Mayer
authors.forename: C
authors.initials: C
authors.lastname: Illingworth
authors.forename: K
authors.initials: K
authors.lastname: Elliott
authors.forename: M
authors.initials: M
authors.lastname: Collier
authors.forename: B
authors.initials: B
authors.lastname: Thompson
authors.forename: B
authors.initials: B
authors.lastname: Perry
authors.forename: A J
authors.initials: AJ
authors.lastname: Michael
mesh_terms: D012437:Adenosylmethionine Decarboxylase / Q000096:biosynthesis*; D000818:Animals; D015317:Biogenic Polyamines / Q000096:biosynthesis; D005786:Gene Expression Regulation; D006801:Humans; D016366:Open Reading Frames / Q000502:physiology; D010944:Plants / Q000201:enzymology*; D014176:Protein Biosynthesis
chemical_list: D015317:Biogenic Polyamines; D012437:Adenosylmethionine Decarboxylase