Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation.
We measure the tissue oxygen and haemoglobin concentrations in the rat brain during modulation of inhaled oxygen concentration (FiO2), using non-invasive frequency domain near-infrared oximetry. The rise in oxygenated haemoglobin concentration and the decline in deoxygenated haemoglobin concentration are demonstrated in correspondence with the modulation of FiO2, which is changed from 20% to 100% in increments of 20%. Furthermore, the tissue oxygenation saturation also shows the corresponding trend and changes ranging from approximately 70% to 90%. The relative changes in deoxygenated haemoglobin concentration are compared to the blood-oxygenation-level-dependent (BOLD) MRI signal recorded during a similar FiO2 protocol. A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed.
Chen
Yu
Y
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. chenyu@mail.med.upenn.edu
Tailor
Dharmesh R
DR
Intes
Xavier
X
Chance
Britton
B
D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism* / Q000502:physiology; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013223:Statistics as Topic; D013382:Subtraction Technique
D006454:Hemoglobins; D010100:Oxygen