The effects of the formula of amino acids enriched BCAA on nutritional support in traumatic patients.
OBJECTIVE
To investigate the formula of amino acid enriched BCAA on nutritional support in traumatic patients after operation.


METHODS
40 adult patients after moderate or large abdominal operations were enrolled in a prospective, randomly and single-blind-controlled study, and received total parenteral nutrition (TPN) with either formula of amino acid (AA group, 20 cases) or formula of amino acid enriched BCAA (BCAA group, 20 cases). From the second day after operation, total parenteral nutrition was infused to the patients in both groups with equal calorie and equal nitrogen by central or peripheral vein during more than 12 hours per day for 6 days. Meanwhile, nitrogen balance was assayed by collecting 24 hours urine for 6 days. The markers of protein metabolism were investigated such as amino acid patterns, levels of total protein, albumin, prealbumin, transferrin and fibronectin in serum.


RESULTS
The positive nitrogen balance in BCAA group occurred two days earlier than that in AA group. The serum levels of total protein and albumin in BCAA group were increased more obviously than that in AA group. The concentration of valine was notably increased and the concentration of arginine was markedly decreased in BCAA group after the formula of amino acids enriched BCAA transfusion.


CONCLUSIONS
The formula of amino acid enriched BCAA may normalize the levels of serum amino acids, reduce the proteolysis, increase the synthesis of protein, improve the nutritional status of traumatic patients after operation.
Wang
Xin-Ying
XY
Medical School of Nanjing University, Research Institute of General Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. wxinying@263.net
Li
Ning
N
Gu
Jun
J
Li
Wei-Qin
WQ
Li
Jie-Shou
JS
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D016037:Single-Blind Method
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D004338:Drug Combinations