Evaluation of antidiarrhoeal activity Rumex maritimus root.
The partitioned n-hexane, ethylacetate and residual methanol extracts of the root of Rumex maritimus were evaluated for antidiarrhoeal activity in mice using castor oil and serotonin induced diarrhoea and also charcoal motility test at 50, 100 and 200 mg/kg body weight dose. Among these, the methanol extract most significantly prolonged the time for induction of diarrhoea, reduced the frequency of diarrhoeal episodes and also decreased the propulsion of charcoal meal through the gastrointestinal tract.
Rouf
A S S
AS
Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. shamsrouf@yahoo.com
Islam
M S
MS
Rahman
M T
MT
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D002368:Castor Oil; D002606:Charcoal / Q000494:pharmacology; D003967:Diarrhea / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D031804:Rumex / Q000737:chemistry*; D012701:Serotonin
D000930:Antidiarrheals; D010936:Plant Extracts; D002606:Charcoal; D012701:Serotonin; D002368:Castor Oil