title: Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications.
abstract: OBJECTIVE
  We report a multigeneration family where colorectal cancer and cancer of multiple diverse anatomic sites, inclusive of transitional cell carcinoma of the upper uroepithelial tract, were manifested in several relatives.
  
  
  METHODS
  A specific pattern of cancer of the colorectum, endometrium, ovary, small bowel, and transitional cell carcinoma, with a vertical distribution of this cancer phenotype through multiple generations, was consonant with a diagnosis of hereditary nonpolyposis colorectal cancer.
  
  
  RESULTS
  Germline mutation testing identified the MSH2 mutation, which segregated with the cancer phenotype. This family study clearly demonstrates the value of genetic testing in the management and treatment decision process.
  
  
  CONCLUSIONS
  We document, perhaps for the first time, how molecular genetic testing in hereditary nonpolyposis colorectal cancer can aid in the identification of a potential renal transplant donor for a relative with the MSH2 mutation who is experiencing renal insufficiency secondary to transitional cell carcinoma.
authors.affiliation: Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
authors.forename: Henry T
authors.initials: HT
authors.lastname: Lynch
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Taylor
authors.forename: Jane F
authors.initials: JF
authors.lastname: Lynch
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Knezetic
authors.forename: Ali
authors.initials: A
authors.lastname: Barrows
authors.forename: Riccardo
authors.initials: R
authors.lastname: Fodde
authors.forename: Juul
authors.initials: J
authors.lastname: Wijnen
authors.forename: Anja
authors.initials: A
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D004268:DNA-Binding Proteins; D005260:Female; D005817:Genetic Counseling; D005838:Genotype; D018095:Germ-Line Mutation; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D051718:MutS Homolog 2 Protein; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D010375:Pedigree; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein