title: Purine degradation in the edible mushroom Agaricus bisporus.
abstract: Agaricus bisporus is able to use urate, allantoin, allantoate, urea and alloxanate as nitrogen sources for growth. The presence of urate oxidase, allantoinase, ureidoglycolase and urease activities, both in fruit bodies and mycelia, points to a degradative pathway for urate similar to that found in various microorganisms. So far all efforts to demonstrate the enzyme responsible for allantoate degradation failed. A urease inhibitor appeared to be present in cell-free extracts from fruit bodies.
authors.affiliation: Department of Microbiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands.
authors.forename: F E
authors.initials: FE
authors.lastname: de Windt
authors.forename: M J M
authors.initials: MJ
authors.lastname: Wagemaker
authors.forename: H J M
authors.initials: HJ
authors.lastname: Op den Camp
authors.forename: C
authors.initials: C
authors.lastname: van der Drift
mesh_terms: D000364:Agaricus / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D000481:Allantoin / Q000378:metabolism; D019760:Amidine-Lyases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000581:Amidohydrolases / Q000378:metabolism; D007093:Imidazoles / Q000378:metabolism; D014503:Urate Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014508:Urea / Q000031:analogs & derivatives* / Q000378:metabolism; D014510:Urease / Q000037:antagonists & inhibitors / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D007093:Imidazoles; C024081:allantoic acid; D014527:Uric Acid; D000481:Allantoin; C021286:alloxanic acid; D014508:Urea; D014503:Urate Oxidase; D000581:Amidohydrolases; D014510:Urease; C019659:allantoinase; D019760:Amidine-Lyases; C033757:ureidoglycollate lyase