Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors.
Recent evidence indicates that CD8(+) T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8(+) T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection.
Byers
Anthony M
AM
Department of Pathology and Laboratory Medicine, Woodruff Memorial Research Building, Rm. 7307, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
Kemball
Christopher C
CC
Andrews
Nicolas P
NP
Lukacher
Aron E
AE
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D011971:Receptors, Immunologic / Q000378:metabolism*; D054340:Receptors, KIR; D015854:Up-Regulation; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*
D011971:Receptors, Immunologic; D054340:Receptors, KIR