Successful retransplantation using rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome.
Posterior Leukoencephalopathy Syndrome (PLES) is a rare but serious neurological condition with many aetiologies. In the era of organ transplantation there have been sporadic reports of calcineurin-inhibitor associated PLES. We describe a case, with subsequent uneventful retransplantation using sirolimus.
Afzali
B
B
Nephrology and Transplantation, Guy's Hospital, London, UK.
Goldsmith
D J A
DJ
D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000009:adverse effects; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D012086:Reoperation; D020123:Sirolimus / Q000627:therapeutic use*; D013577:Syndrome; D016559:Tacrolimus / Q000009:adverse effects
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus