title: Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions: case report.
abstract: Phenytoin is a highly effective and widely prescribed anticonvulsant agent, but it can be associated with dose-related side effects and hypersensitivity reactions. We present a case of phenytoin-induced cholestatic hepatotoxicity in a 47-year-old woman who had exfoliative dermatitis, an increase in liver enzymes with a cholestatic pattern, and eosinophilia after 25 days of phenytoin therapy. The diagnostic workup showed no other possible causes, and the results of a percutaneous liver biopsy were consistent with drug-induced toxic hepatitis. Within 3 weeks after discontinuing phenytoin therapy, her liver function tests returned to normal values.
authors.affiliation: Internal Medicine and Gastroenterology Clinic, Sisli Etfal Education and Research Hospital, Istanbul, Turkey. yukselaltuntas@yahoo.com
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Altuntaş
authors.forename: Bülent
authors.initials: B
authors.lastname: Oztürk
authors.forename: Levent
authors.initials: L
authors.lastname: Erdem
authors.forename: Gürsel
authors.initials: G
authors.lastname: Günes
authors.forename: Sema
authors.initials: S
authors.lastname: Karul
authors.forename: Sema
authors.initials: S
authors.lastname: Uçak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sengül
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D003873:Dermatitis, Exfoliative / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D012640:Seizures / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin