Damage to the erythrocyte membrane caused by chlorophenoxyacetic herbicides.
We studied the damage caused to erythrocyte membranes by chlorophenoxyacetic herbicides. An increase in haemolysis was observed. The compounds investigated caused lipid bilayer damage by lipid peroxidation, as well as an increase in membrane fluidity at the 16th carbon atom of fatty acids was observed. Metabolites caused damage to membrane proteins - the free SH group content was increased. Higher toxicity of metabolites compared to basic compounds was observed.
Duchnowicz
Piotr
P
Department of Biophysics of Environmental Protection, University of Łódź, Banacha 12/16, Poland.
Koter
Maria
M
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity; D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000633:toxicity; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects; D008565:Membrane Proteins / Q000737:chemistry / Q000187:drug effects; D012997:Solvents; D013438:Sulfhydryl Compounds / Q000737:chemistry
D006540:Herbicides; D008565:Membrane Proteins; D012997:Solvents; D013438:Sulfhydryl Compounds; D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D008456:2-Methyl-4-chlorophenoxyacetic Acid