Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndrome.
We describe the case of a bilateral parotid mucosa-associated lymphoid tissue (MALT) lymphoma associated with 2 years history of Sjögren's syndrome (SS), which was linked to human herpes virus 8 (HHV-8) infection. Using polymerase chain reaction (PCR) assay HHV-8 sequences were detectable in the lymphoma tissue of both sides. Serologic testing of the patient revealed HHV-8 antibodies in enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA). Immunohistologic staining with two antibodies against open reading frame (ORF) 26 and v-cyclin homologues of HHV-8 revealed positive staining of the salivary acinic cells whereas the lymphoma cells were negative. The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed.
Klussmann
Jens Peter
JP
Department of Otorhinolaryngology, University of Cologne, D-50924 Cologne, Germany. peter.klussmann@uni-koeln.de
Wagner
Mathias
M
Guntinas-Lichius
Orlando
O
Müller
Andreas
A
D000956:Antigens, Viral / Q000032:analysis*; D016213:Cyclins / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D004848:Epithelium / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000821:virology*; D008875:Middle Aged; D016366:Open Reading Frames / Q000235:genetics; D010306:Parotid Gland / Q000821:virology; D010307:Parotid Neoplasms / Q000821:virology*; D012859:Sjogren's Syndrome / Q000150:complications*; D014764:Viral Proteins
D000956:Antigens, Viral; D016213:Cyclins; D004279:DNA, Viral; D014764:Viral Proteins