Sulphotransferases acting on mucin-type oligosaccharides.
This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.
Brockhausen
I
I
Department of Medicine, Human Mobility Research Centre, Queen's University, Kingston, Ontario, Canada. brockhau@post.queensu.ca
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism*; D015238:Sulfotransferases / Q000145:classification / Q000378:metabolism* / Q000502:physiology
D009077:Mucins; D009844:Oligosaccharides; D015238:Sulfotransferases