title: Endocrine tumors of the uterine cervix: incidence, demographics, and survival with comparison to squamous cell carcinoma.
abstract: OBJECTIVE
  The aim was to describe the epidemiology of endocrine tumors of the cervix in comparison with invasive squamous cell carcinomas using population-based data reported to the Surveillance, Epidemiology and End-Results (SEER) program.
  
  
  METHODS
  Retrospective analysis of actively followed cases reported to SEER from 1973 to 1998. Incidence, demographic characteristics, and survival were compared for endocrine and squamous tumors.
  
  
  RESULTS
  There were 239 cases of endocrine tumors and 18,458 cases of invasive squamous cell carcinoma of the cervix included in the study. Mean age at diagnosis was 49 years for endocrine tumors versus 52 years for squamous cell carcinoma (P < 0.01). Endocrine tumors were more likely to present at a later FIGO stage (P < 0.01), and to have lymph node involvement at diagnosis (57 vs 18%, P < 0.01) compared to squamous cell carcinoma. Observed median survival for women with endocrine tumors was 22 months versus 10 years for women with squamous cell carcinoma. Age and FIGO stage-adjusted hazards of death were 1.84 times greater for endocrine tumors than for squamous cell carcinoma (95% CI 1.52-2.23). At all stages of disease, survival was worse for women with endocrine tumors compared to women with squamous cell carcinomas.
  
  
  CONCLUSIONS
  Endocrine tumors of the cervix are extremely aggressive and survival is poor regardless of stage at diagnosis.
authors.affiliation: University of Maryland School of Medicine, Department of Epidemiology and Preventive Medicine, Baltimore, MD, USA. zey3@cdc.gov
authors.forename: Margaret E
authors.initials: ME
authors.lastname: McCusker
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Coté
authors.forename: Limin X
authors.initials: LX
authors.lastname: Clegg
authors.forename: Fattaneh J
authors.initials: FJ
authors.lastname: Tavassoli
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D018426:SEER Program; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology