Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults.
A multicenter prospective study was performed on 160 asthmatic adults suffering from acute episodes of bronchitis and 88 non-asthmatic controls, to investigate potential associations among Chlamydia pneumoniae infection and/or anti-C. pneumoniae heat shock protein 10 antibodies, and asthma. We used micro-immunofluorescence to detect serum anti-C. pneumoniae IgG, IgA and IgM antibodies and enzyme-linked immunosorbent assay to detect serum anti-Chsp10 peptide IgG antibodies. The serological prevalence of C. pneumoniae was 73.1%. An association was observed between the presence of anti-Chsp10 antibodies and adult onset asthma. The humoral immune responses were not confined to any particular region of the Chsp10 protein.
Betsou
Fotini
F
Biobanque de Picardie, 16 rue Fernel, 80000 Amiens, France. fay.betsou@biobanque-picardie.com
Sueur
Jean Marie
JM
Orfila
Jeanne
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000097:blood*; D001249:Asthma / Q000276:immunology*; D018835:Chaperonin 10 / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D011446:Prospective Studies; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D018835:Chaperonin 10