Sipatrigine and oligodendrocyte and axonal pathology following transient focal cerebral ischaemia in the rat.
The ability of Sipatrigine (BW619c89), a sodium and calcium channel blocker to protect neuronal perikarya, axons and oligodendrocytes from ischaemia has been evaluated in the rat. Sipatrigine (30 mg/kg) was administered 15 min prior to transient (2 h) occlusion of the middle cerebral artery with animals being sacrificed 24 h after induction of ischaemia. Sipatrigine significantly reduced the volumes of neuronal perikarya damage (by 35%) and oligodendrocyte damage (by 54%). Sipatrigine minimally altered axonal damage (median scores: vehicle approximately 30, Sipatrigine approximately 26). The present report provides evidence that neuronal perikarya, axons and oligodendrocytes may be differentially protected by pharmacological intervention in focal cerebral ischaemia.
McCracken
Eileen
E
Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, UK.
Dewar
Deborah
D
McCulloch
James
J
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009836:Oligodendroglia / Q000187:drug effects / Q000473:pathology*; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D010879:Piperazines; D011743:Pyrimidines; C081980:sipatrigine