title: African-American heredity prostate cancer study: a model for genetic research.
abstract: A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.
authors.affiliation: Dept of Urology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
authors.forename: I J
authors.initials: IJ
authors.lastname: Powell
authors.forename: J
authors.initials: J
authors.lastname: Carpten
authors.forename: G
authors.initials: G
authors.lastname: Dunston
authors.forename: R
authors.initials: R
authors.lastname: Kittles
authors.forename: J
authors.initials: J
authors.lastname: Bennett
authors.forename: G
authors.initials: G
authors.lastname: Hoke
authors.forename: C
authors.initials: C
authors.lastname: Pettaway
authors.forename: S
authors.initials: S
authors.lastname: Weinrich
authors.forename: S
authors.initials: S
authors.lastname: Vijayakumar
authors.forename: C A
authors.initials: CA
authors.lastname: Ahaghotu
authors.forename: W
authors.initials: W
authors.lastname: Boykin
authors.forename: T
authors.initials: T
authors.lastname: Mason
authors.forename: C
authors.initials: C
authors.lastname: Royal
authors.forename: A
authors.initials: A
authors.lastname: Baffoe-Bonnie
authors.forename: J
authors.initials: J
authors.lastname: Bailey-Wilson
authors.forename: K
authors.initials: K
authors.lastname: Berg
authors.forename: J
authors.initials: J
authors.lastname: Trent
authors.forename: F
authors.initials: F
authors.lastname: Collins
mesh_terms: D000368:Aged; D000954:Antigens, Surface / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D050827:Syntaxin 1; D014481:United States / Q000453:epidemiology
chemical_list: D000954:Antigens, Surface; D009419:Nerve Tissue Proteins; D050827:Syntaxin 1