[Functioning of opisthorchiasis-tuberculosis parasitocenosis at different stages of invasion (experimental investigation)].
In experiments on golden hamsters the mutual influence of the co-members of opisthorchiasis-tuberculosis parasitocenosis has been established. This mutual influence depends on the stage of invasion and the state of the immune reactivity of the host. After additional immunization of the experimental animals with sheep red blood cells (SRBC) parasitocenosis formed special immune response different from those observed in both opisthorchiasis and tuberculosis. In cases of mixed pathology (opisthorchiasis-tuberculosis), reproduced at the acute stage of invasion, additional body reserves are seemingly switched on, thus leading the immunity system to increased functioning with respect to specific and heterologous antigens. In the chronization of invasion a decreased formation of antibodies to heterologous antigens (SRBC) together with a simultaneous decreased level of specific antiopisthorchiasis and antituberculosis immune response suggest that the reserve capacities of the host immune system, especially of humoral factors, are exhausted.
Kashuba
E A
EA
Research Institute of Territorial Infectious Pathology, State Medical Academy, Tyumen, Russia.
Podkletnova
L F
LF
Stepanova
T F
TF
Chebysheva
E V
EV
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000909:Antibodies, Helminth / Q000097:blood; D006224:Cricetinae; D004195:Disease Models, Animal; D006385:Hemagglutination Inhibition Tests; D006790:Host-Parasite Interactions / Q000276:immunology; D007958:Leukocyte Count; D009169:Mycobacterium tuberculosis / Q000276:immunology; D009889:Opisthorchiasis / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D009891:Opisthorchis / Q000276:immunology / Q000502:physiology*; D013154:Spleen / Q000276:immunology; D014376:Tuberculosis / Q000097:blood / Q000276:immunology*
D000907:Antibodies, Bacterial; D000909:Antibodies, Helminth