[Clinical efficacy of citalopram in patients with obsessive-compulsive disorder].
16 patients (9 female, 7 male; mean age 32.69 +/- 10.30) with coexisting obsessive-compulsive disorder (OCD) and depression were treated for 6 weeks with citalopram (10-60 mg; mean dosage after 6 weeks--25.71 +/- 12.83 mg). Their mental state was evaluated in the 7th, 14th, 28th and 42nd of treatment by the use of psychiatric examination and self-assessment clinical scales. After 6 weeks of treatment 5 patients were in full remission, 7 in partial remission (totally 75% of patients were responders) and 4 still suffered from OCD or depressive symptoms. In the 1st week of treatment 5 patients complained on temporary aggravation of symptoms but it turned out to have no prognostic value. It is recommended to find early signs of final clinical response.
Jakitowicz
Janusz
J
Zakład Psychiatrii Biologicznej Katedry Chorób Psychicznych AM w Gdańsku. jjakit@amg.gda.pl
Nowicki
Zbigniew
Z
Wiśniewski
Grzegorz
G
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000627:therapeutic use*; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors