Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT.
Novel radiolabeled O(6)-benzylguanine derivatives, 6-O-[(11)C]-[(methoxymethyl)benzyl]guanines ([(11)C]p-O(6)-MMBG, 1a; [(11)C]m-O(6)-MMBG, 1b; ([(11)C]o-O(6)-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (AGT).
Liu
Xuan
X
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Zheng
Qi-Huang
QH
Fei
Xiangshu
X
Wang
Ji-Quan
JQ
Ohannesian
David W
DW
Erickson
Leonard C
LC
Stone
K Lee
KL
Hutchins
Gary D
GD
D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006801:Humans; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014055:Tomography, Emission-Computed / Q000379:methods*
D004791:Enzyme Inhibitors; D006147:Guanine; D019853:O(6)-Methylguanine-DNA Methyltransferase