title: Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection.
abstract: Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (K(a)) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the K(a) of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pK(a) values obtained through the method were in agreement with the values by typical spectrophotometric method.
authors.affiliation: Department of Physiology and Pharmacology, Nanjing Medical University, Jiangsu 210029, Nanjing, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.forename: Tianshu
authors.initials: T
authors.lastname: Zhou
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods
chemical_list: D000903:Antibiotics, Antineoplastic