title: A triangulation approach to historical exposure assessment for the carbon black industry.
abstract: The determination of cumulative exposures for individual workers is necessary for research and practice of occupational health and hygiene. Reconstruction of exposures for a study of respiratory morbidity was needed to study the effects of exposure to carbon black production. Approximately 15,800 exposure estimates were needed. There were 22 plants, a 40-year time span, six job categories, and three types of dust-exposure metrics (respirable, inhalable, and "total" dust). Three information sources were used: 1) Industrial hygiene air level measurements where available (several industry-wide surveys had been conducted). 2) A formal process survey identifying specific dates and types of process and control changes. 3) An Historical Relative Exposure Rating Scale; plant health and safety personnel used this spreadsheet-based rating scheme to quantify exposures before and between years of actual measurement relative to a reference year in which measurements were available. A job-exposure matrix was calculated by integrating these three methods. Linear scaling factors were identified to interconvert geometric to arithmetic means and to interconvert total and inhalable dust. Individual worker cumulative exposures were then calculated based upon job histories linked with the job-exposure matrix. The nine-step process for integrating all available relevant data was effective in estimating the exposures for each of the cells of the job-exposure matrix. Among the 1680 workers participating, the mean cumulative inhalable dust exposure was 48.4 mg-years/m3. Early years contribute disproportionately to the cumulative exposures of individuals since levels have declined significantly over time. The use of multiple sources of information, including a relative exposure rating instrument, significantly facilitates reconstruction of historical exposures. Inadequate adjustment for temporal trends can lead to underestimation of cumulative exposures and significantly affect estimation of dose-effect relationships. These methods are applicable to other situations requiring estimation of cumulative exposure with sparse industrial hygiene data in early years.
authors.affiliation: Division of Occupational and Environmental Medicine, Department of Family Medicine, University of California, Los Angeles, 10940 Wilshire Blvd, Ste #1220, Los Angeles, CA 90024, USA. pharber@mednet.ucla.edu
authors.forename: Philip
authors.initials: P
authors.lastname: Harber
authors.forename: Henry
authors.initials: H
authors.lastname: Muranko
authors.forename: Stephen
authors.initials: S
authors.lastname: Shvartsblat
authors.forename: Sophia
authors.initials: S
authors.lastname: Solis
authors.forename: Ani
authors.initials: A
authors.lastname: Torossian
authors.forename: Tilly
authors.initials: T
authors.lastname: Oren
mesh_terms: D002244:Carbon / Q000009:adverse effects* / Q000266:history; D049673:History, 20th Century; D006801:Humans; D007221:Industry / Q000266:history; D007587:Job Description; D008171:Lung Diseases / Q000209:etiology*; D008487:Medical History Taking / Q000379:methods*; D008962:Models, Theoretical; D009017:Morbidity; D009656:North America; D016273:Occupational Exposure / Q000032:analysis / Q000266:history*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D002244:Carbon