[Bacillus anthracis, prions, Coxiella burnetii].
The detection kits for Bacillus anthracis, an isoform of host prion and Coxiella burnetii, using genetic technology are still not generalized. For B. anthracis target genes for detection would be genes of toxins. Although it is difficult to detect prions related to prion diseases before death, some mutants of prion gene in leukocytes and 14-3-3 proteins in cerebrospinal fluid are detectable in living patients suffering from Creutzfeldt-Jakob disease. The gene of superoxide dismutase in Coxiella burnetii is a useful target for detecting this Rickettsiae.
Machida
Katsuhiko
K
Department of Laboratory Medicine, Jikei University School of Medicine.
D000818:Animals; D000881:Anthrax / Q000175:diagnosis; D001408:Bacillus anthracis / Q000235:genetics* / Q000302:isolation & purification*; D016997:Coxiella burnetii / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods; D017096:Prion Diseases / Q000175:diagnosis; D011328:Prions / Q000235:genetics* / Q000302:isolation & purification*; D011778:Q Fever / Q000175:diagnosis
D011328:Prions