title: Discrimination of Exner's area and the frontal eye field in humans--functional magnetic resonance imaging during language and saccade tasks.
abstract: In the left frontal lobe, Exner's area (EXA), which is responsible for writing and reading, is located close to the frontal eye field (FEF), which is responsible for eye movements. To discriminate EXA from FEF anatomically and functionally, functional magnetic resonance imaging was conducted in 12 healthy volunteers. The saccadic eye movement experiment activated a region defined as the FEF, whereas three language experiments that included translation between grapheme and phoneme activated another region defined as EXA. EXA was found to be located only 1.5 cm apart from the FEF in the Talairach brain template. By conducting the saccade and language experiments in the same individuals, this study was able to successfully separate EXA from FEF.
authors.affiliation: Medical Vision Laboratory, Life Electronics Research Center, AIST, 1-8-31, Midorigaoka, Ikeda, Osaka, Japan. kayako.matsuo@aist.go.jp
authors.forename: Kayako
authors.initials: K
authors.lastname: Matsuo
authors.forename: Chikako
authors.initials: C
authors.lastname: Kato
authors.forename: Chika
authors.initials: C
authors.lastname: Sumiyoshi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Toma
authors.forename: Dinh Ha
authors.initials: DH
authors.lastname: Duy Thuy
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Moriya
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Nakai
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D012438:Saccades / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*