[Toxicogenomics--a new paradigm of toxicology and birth of reverse toxicology].
Toxicogenomics is, similar to other genome science fields, based on DNA microarray and/or DNA chip technologies, which has enabled a large number of gene expressions, thus, have been applied to such functional genomics as pharmacogenomics, oncogenomics, proteomics, metabonomics, etc. Toxicogenomics has advantages such as deducing the number of test animals and the test period, and adopts simpler techniques using new biomarkers. What toxicogenomics can offer to conventional toxicology is given herein.
Hirabayashi
Yoko
Y
Cellular & Molecular Toxicology Division, Center for Biological Safety and Research, National Institute of Health Sciences, 1-18-1 Kamiyohga, Setagayaku, Tokyo, 158-8501, Japan. yokohira@nihs.go.jp
Inoue
Tohru
T
D019295:Computational Biology; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010597:Pharmacogenetics; D040901:Proteomics; D014116:Toxicology / Q000379:methods