IgA deficiency with membranous glomerulonephritis: a case report and review.
Selective immunoglobulin A (IgA) deficiency may result in a predisposition to recurrent sinopulmonary infection and allergic diseases. IgA deficiency may also play a role in the development of autoimmune disorders. Selective IgA deficiency associated with glomerulonephritis was rare, while the clinical presentation in IgA deficiency-associated glomerulonephritis was variable. We report an 83 year-old male with selective IgA deficiency associated with membranous glomerulonephritis. He presented with nephrotic syndrome. Percutaneous renal needle biopsy showed diffuse global thickening and rigidity of glomerular capillary walls, mildly diffuse segmental expansion of mesangial matrix, focal and cortical scar with segmental obsolescence of glomeruli. Heavy IgG and moderate C3 deposits were found on immunofluorescence. We also review the previous cases of IgA deficiency with glomerulonephritis. Several clues were rendered to establish the association between IgA deficiency and membranous glomerulonephritis.
Huang
Jeng-Bin
JB
Division of Nephrology, Department of Medicine, Veterans' General Hospital-Taipei and School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Yang
Wu-Chang
WC
Hu
Ching-Chung
CC
Yang
An-Han
AH
Lin
Chih-Ching
CC
D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000473:pathology*; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000175:diagnosis; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index