title: Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye.
abstract: Tissue polarity in Drosophila is regulated by a number of genes that are thought to function in a complex, many of which interact genetically and/or physically, co-localize, and require other tissue polarity proteins for their localization. We report the enhancement of the strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle. Flamingo is autonomously required for the establishment of ommatidial polarity. Its localization is dynamic throughout ommatidial development and is dependent on Frizzled and Notch. Flamingo and Strabismus co-localize for several rows posterior to the morphogenetic furrow and subsequently diverge. While neither of these proteins is required for the other's localization, Prickle localization is influenced by Strabismus function. Our data suggest that Strabismus, Flamingo and Prickle function together to regulate the establishment of tissue polarity in the Drosophila eye.
authors.affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Rawls
authors.forename: Tanya
authors.initials: T
authors.lastname: Wolff
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D034281:Dynamins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D005123:Eye / Q000196:embryology*; D051157:Frizzled Receptors; D060588:LIM Domain Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D051880:Receptors, Notch; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D015820:Cadherins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D060588:LIM Domain Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D043562:Receptors, G-Protein-Coupled; D051880:Receptors, Notch; C111638:Vang protein, Drosophila; D033921:Vesicular Transport Proteins; C058784:fz protein, Drosophila; C100411:hook protein, Drosophila; C121600:pk protein, Drosophila; C121420:stan protein, Drosophila; D034281:Dynamins; C439628:shi protein, Drosophila