[The influence of high frequency partial liquid ventilation on the cardiopulmonary function in dogs with inhalation injury].
OBJECTIVE
To investigate the influence of high frequency partial liquid ventilation (HFJV) on the cardiopulmonary function in dogs with inhalation injury.


METHODS
Sixteen mongrel dogs inflicted by hot steam inhalation were subjected to severe inhalation injury and were randomly divided into control (C) and treatment (T) groups. The dogs in both groups were all given HFJV. In addition, the dogs in T group were simultaneously supplied with perfluorocarbon liquid (3 ml/kg) into the lungs slowly via tracheal intubation for liquid ventilation. The blood gas analysis, pulmonary compliance, airway resistance and hemodynamic parameters were determined at 30, 60 and 90 minutes after ventilation.


RESULTS
The PaO(2) in T group increased progressively, which was significantly higher than the post-injury value at all time points (P < 0.05). While the PaO(2) in C group exhibited no difference to the post-injury value at all time points. The PaCO(2) in T group increased obviously and was higher than the post-injury value at 60 and 90 post-ventilation minutes (P < 0.05). Furthermore, the PaO(2) in all the time points in T group was a little higher than that in C group (P > 0.05) and PaCO(2) in T group was much higher than that in C group at 90 min after ventilation (P < 0.05). But there was no difference between the two groups in terms of dynamic/static pulmonary compliance and airway resistance as well as the hemodynamics.


CONCLUSIONS
Compared with simple HFJV, high frequency partial liquid ventilation seemed to be beneficial to the oxygenation after inhalation injury and to be no influence on the hemodynamics.
Guo
Guanghua
G
Burn Center, The First Affiliated Hospital of Jiangxi Medical College. Nanchang 330006, P.R. China.
Qian
Kejian
K
Zhu
Feng
F
Xiong
Long
L
Wang
Lianqun
L
Li
Guohui
G
Zhao
Weilu
W
Cao
Yong
Y
D000403:Airway Resistance; D000818:Animals; D001784:Blood Gas Analysis; D002059:Burns, Inhalation / Q000503:physiopathology* / Q000628:therapy*; D004285:Dogs; D005260:Female; D006611:High-Frequency Jet Ventilation; D021061:Liquid Ventilation; D008170:Lung Compliance; D008297:Male; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods*; D012129:Respiratory Function Tests; D013997:Time Factors