title: Oxidative stress and hemorheological changes induced by acute treadmill exercise.
abstract: The present investigation was designed to evaluate the acute effect of aerobic exercise on oxidative stress and the flow properties of the blood. Fourteen clinically healthy subjects (7 men and 7 women aged 56+/-19 yr) underwent maximal treadmill exercise with blood samples drawn prior to and immediately after exercise. Post-exercise significant increases were observed in plasma lipid hydroperoxides from 6.5+/-2.0 microM to 7.9+/-1.9 microM (p<0.0001) and the relative concentration of plasma fluorescent products associated with red cell peroxidation from 138+/-28 RF to 220+/-92 RF (p<0.005). After exercise there was a rise in the hematocrit from 41.4+/-3.7% to 44.4+/-4.1% (p<0.0001), increases in whole blood viscosity at shear rates of 22.5/sec to 450/sec (p<0.0005), an increase in plasma viscosity from 1.27+/-0.12 cP to 1.36+/-0.11 cP (p<0.01), an increase in red cell rigidity from 2.44+/-0.48 cP to 2.62+/-0.42 cP (p<0.001) and a decrease in erythrocyte sedimentation rate from 26.9+/-18.6 mm/h to 22.5+/-15.9 mm/h (p<0.01). The findings suggest that acute aerobic exercise induces oxidative damage to red blood cells and adversely affects rheological properties of the peripheral blood.
authors.affiliation: National Institute on Aging, National Institutes of Health, Molecular Dynamics Section and the Laboratory of Cardiovascular Sciences, Baltimore, MD 21224, USA. ranjeet_ajmani@intaspharma.com
authors.forename: Ranjeet S
authors.initials: RS
authors.lastname: Ajmani
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Fleg
authors.forename: A Andrew
authors.initials: AA
authors.lastname: Demehin
authors.forename: Jeanette G
authors.initials: JG
authors.lastname: Wright
authors.forename: Frances
authors.initials: F
authors.lastname: O'Connor
authors.forename: Jane M
authors.initials: JM
authors.lastname: Heim
authors.forename: Edward
authors.initials: E
authors.lastname: Tarien
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Rifkind
mesh_terms: D000328:Adult; D000332:Aerobiosis; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001799:Blood Sedimentation; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation / Q000502:physiology; D005080:Exercise Test; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006339:Heart Rate; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D018056:Hemorheology; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D012016:Reference Values
chemical_list: D006454:Hemoglobins; D008054:Lipid Peroxides; D005340:Fibrinogen; D010100:Oxygen