title: Utility of serosal stamp cytology as an indicator for high-risk peritoneal metastasis in colorectal cancer surgery.
abstract: OBJECTIVE
  Although peritoneal lavage cytology is widely performed during surgery for gastric cancer and the results have been reported to provide an accurate prognostic factor, its value has not been well established in colorectal cancer. In this study, we demonstrated the utility of serosal stamp cytology from the viewpoint of cell adhesion molecules.
  
  
  METHODS
  Between 1997 and 1999, peritoneal lavage cytology and serosal stamp cytology were performed in 34 patients with resectable colorectal cancer. Epithelial cadherin (E-cadherin) was examined as an index of the progress degree of peritoneal metastasis.
  
  
  RESULTS
  Although peritoneal lavage cytology was positive in one case, serosal stamp cytology was positive in 10 cases. E-cadherin expression was lost in all peritoneal lavage cytology and/or serosal stamp cytology positive patients.
  
  
  CONCLUSIONS
  Our data indicate that serosal stamp cytology is more sensitive and simple than peritoneal lavage cytology. Serosal stamp cytology may be useful in identifying patients at high risk for peritoneal recurrence.
authors.affiliation: First Department of Surgery, Gunma University Faculty of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan. hojima@showa.gunma-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ojima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Masuda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010529:Peritoneal Cavity / Q000473:pathology; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012704:Serous Membrane / Q000473:pathology*
chemical_list: D015820:Cadherins