Intravenous magnesium sulphate effect on maternal serum and amniotic fluid cytokines levels in preterm labour patients.
Our objective was to evaluate the effect of intravenous magnesium sulphate administration to patients with preterm labour on maternal serum and amniotic fluid IL-1beta, IL-6, IL-10 and TNFalpha concentrations. Thirty-six patients at 24-34 weeks of singleton gestation, who presented with contractions (> or = 8 in 60 min) had amniocentesis to rule out intrauterine infection. The patients received intravenous MgSO4 for tocolysis. Twenty-six patients had amniocentesis performed before initiation of MgSO4 (controls) while 10 others had the procedure during tocolytic therapy (study patients). Magnesium, IL-1beta, IL-6, TNFalpha and IL-10 concentrations were measured. Study and control groups were statistically compared using Student t test. Mean magnesium levels were significantly higher in the study group (P < 0.01). There were no significant differences between the cytokines levels in maternal serum and in amniotic fluid between the groups. Our results suggest that the mechanism of magnesium as a tocolytic agent may not be mediated via the examined cytokines.
Mezad
Daphna
D
Department of Obstetrics & Gynecology, Soroka University Medical Center, Faculty of health science, Ben Gurion University of the Negev, Beer Sheva, Israel.
Hallak
Mordechai
M
Huleihel
Mahmoud
M
Gortzak-Uzan
Limor
L
Smolin
Ana
A
Mazor
Moshe
M
D000328:Adult; D000653:Amniotic Fluid / Q000187:drug effects / Q000378:metabolism*; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000494:pharmacology*
D016207:Cytokines; D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D008274:Magnesium