Synthesis and in vitro leishmanicidal activity of some hydrazides and their analogues.
Twenty-one hydrazides were synthesized by treating different esters with hydrazine hydrate. Substituted hydrazides were obtained by treating hydrazides with alkyl/aryl/acyl halides. Some of these compounds exhibit potential in vitro leishmanicidal activity. The structures of all the synthesized compounds were confirmed by spectroscopic analysis.
Khan
Khalid Mohammad
KM
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan. hassaan2@super.net.pk
Rasheed
Maimona
M
Zia-Ullah
Hayat
Safdar
S
Kaukab
Farhana
F
Choudhary
M Iqbal
MI
Atta-ur-Rahman
Perveen
Shahnaz
S
D000478:Alkylation; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D018320:Leishmania major / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents
D000981:Antiprotozoal Agents; D006834:Hydrazines; D007202:Indicators and Reagents; D012997:Solvents; C029424:hydrazine