Atypical antipsychotics in the treatment of schizophrenia.
Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symptoms as well as treatment-refractory patients. The most important side effects as well as their possible interactions are reviewed in detail. Recommendations for the clinical use are given.
Bridler
René
R
Psychiatric University Hospital Zurich, Heliosstrasse 32, Postfach 31, CH-8029 Zurich, Switzerland. rene.bridler@puk.zh.ch
Umbricht
Daniel
D
D000342:Affective Symptoms / Q000188:drug therapy; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D004347:Drug Interactions; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D011388:Prolactin / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy*; D013406:Suicide, Attempted / Q000517:prevention & control; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
D014150:Antipsychotic Agents; D001786:Blood Glucose; D011388:Prolactin