[Ganglionic blockers in abdominal surgery: facts and hypotheses. 2.Clinical, pathophysiological and pharmacological aspects of ganglionic blocker use].
The authors discuss facts and hypotheses on the effects of benzohexonium upon the motor activity of the intestine and the significance of N-cholinolytics for prophylactics and treatment of postoperative pareses of the gastrointestinal tract. The ganglioblockers possess antistress effect, reduce the degree of pathological vegetative reactions and facilitate realization of the mechanisms of selfregulation of functions of the small and large intestine. Using benzohexonium during operation and in the first days after it makes the intestinal pareses less frequent. N-cholinolytics however do not have a considerable stimulating influence on the contracting activity of the gastrointestinal tract that accounts for their not high effectiveness in treatment of early functional motor evacuatory disorders. The points of action of gangliolytics, those at the level of the intestinal wall included, can not be considered to be completely established, as well as the mechanisms of their indirect effect. The ganglionic blockade should be considered as the basic method of prophylactics of the postoperative paresis of the intestine.
Polushin
Iu S
IuS
Maĭstrenko
N A
NA
Kurygin
Al A
AA
Pashchenko
O V
OV
D000005:Abdomen / Q000601:surgery*; D000818:Animals; D002415:Cats; D003112:Colonic Pseudo-Obstruction / Q000517:prevention & control; D004285:Dogs; D005730:Ganglionic Blockers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006584:Hexamethonium Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000517:prevention & control*; D007421:Intestine, Small / Q000187:drug effects; D011183:Postoperative Complications / Q000517:prevention & control*; D013997:Time Factors
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; C021628:benzohexonium