In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.
A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride 1, has been investigated for its antitumor properties. In vitro studies demonstrate that 1 is active against HCT-15, AGS, PC-3, and LNCaP tumor cells. Cell cycle analysis of the HCT-15 cells by flow cytometry revealed elongation of the G1 phase of the cell cycle leading to growth inhibition. Administration of 1 to Balb/C mice inoculated with syngenic meth/A cells demonstrated statistically significant dose-dependent survival time.
Pillarsetty
Nagavarakishore
N
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
Katti
Kavita K
KK
Hoffman
Timothy J
TJ
Volkert
Wynn A
WA
Katti
Kattesh V
KV
Kamei
Hideo
H
Koide
Tatsurou
T
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000401:mortality; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D010720:Phosphines / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D050607:Organogold Compounds; D009942:Organometallic Compounds; D010720:Phosphines; C473479:tetrakis((trishydroxymethyl)phosphine)gold(I)