Deleterious genetic influence of CX3CR1 genotypes on HIV-1 disease progression.
We previously reported that patients homozygous for a specific mutation (M280) in the chemokine receptor CX3CR1 progressed to AIDS more rapidly than those with other genotypes. This deleterious effect would predict that a cohort of prevalent patients would be depleted in M280 carriers, because these patients would have disappeared before recruitment. This hypothesis is confirmed in this new study based on the French SEROCO cohort showing that patients homozygous for the M280 allele were rare among the seroprevalent group. These results may explain the conflicting results published on the impact of CX3CR1 polymorphism in seroconverters.
Faure
Sophie
S
INSERM U543, Hôpital Salpêtrière, Paris, France.
Meyer
Laurence
L
Genin
Emmanuelle
E
Pellet
Philippe
P
Debré
Patrice
P
Théodorou
Ioannis
I
Combadière
Christophe
C
D000483:Alleles; D000073883:CX3C Chemokine Receptor 1; D015331:Cohort Studies; D018450:Disease Progression; D005602:France; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000209:etiology; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1; D006720:Homozygote; D006801:Humans; D008565:Membrane Proteins; D009154:Mutation; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics*
D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D008565:Membrane Proteins; D019707:Receptors, Chemokine