The potential role of bisphosphonates in prostate cancer.
Skeletal morbidity secondary to metastases and osteoporosis is common in patients with advanced prostate cancer. Despite the typically sclerotic nature of prostate cancer metastases, osteoclast mediated osteolysis may play a significant role. This review addresses the newly recognised antitumour effects of bisphosphonates in addition to their role in inhibiting osteoclast mediated bone resorption. Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed.
Oades
G M
GM
Department of Urology, St George's Hospital and Medical School, London, UK. goades@sghms.ac.uk
Coxon
J
J
Colston
K W
KW
D000230:Adenocarcinoma / Q000098:blood supply / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000556:secondary*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001859:Bone Neoplasms / Q000098:blood supply / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000556:secondary*; D001862:Bone Resorption / Q000188:drug therapy*; D002118:Calcium / Q000378:metabolism; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D018450:Disease Progression; D006706:Homeostasis; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D010010:Osteoclasts / Q000187:drug effects; D010014:Osteolysis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000473:pathology*; D016032:Randomized Controlled Trials as Topic; D051381:Rats
D020533:Angiogenesis Inhibitors; D004164:Diphosphonates; D002118:Calcium