title: Cytotoxic triterpenes from Ligulariopsis shichuana.
abstract: Five olean-12-ene triterpenes (1-5) were isolated from the whole plant of Ligulariopsis shichuana. Their structures were elucidated by spectroscopic methods, including IR, EIMS positive HRSIMS, 1DNMR, and 2DNMR. Among them, 16beta,28-dihydroxyolean-12-en-3-one (3), olean-12-en-3beta,6beta,16beta,28-tetraol (4), 6beta,16beta-dihydroxyolean-12-en-3-one (5) are new compounds. In addition, compounds 4 and 5 showed cytotoxic activities on human hepatomacells (SMMC-7721), human ovarian neoplasm cells (HO-8910) and human hepatocytes cells (LO2).
authors.affiliation: National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, PR China.
authors.forename: Wen-Shu
authors.initials: WS
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Wang
authors.forename: Zhong-Jian
authors.initials: ZJ
authors.lastname: Jia
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D019659:Asteraceae / Q000737:chemistry*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes