Exploiting host microtubule dynamics: a new aspect of bacterial invasion.
During infection, many pathogenic bacteria modulate the actin cytoskeleton of eukaryotic host cells to facilitate various infectious processes such as the attachment to or invasion of epithelial cells. Additionally, some pathogenic bacteria are capable of modulating the dynamics of host microtubule (MTs). Although the molecular basis for this is still poorly understood, a recent study of the Shigella VirA effector protein, which is delivered via a type III secretion system, suggests that MT destabilization plays an important role in Shigella infection.
Yoshida
Sei
S
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-Ku, Tokyo 108-8639, Japan.
Sasakawa
Chihiro
C
D000199:Actins / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology / Q000503:physiopathology; D001426:Bacterial Proteins / Q000378:metabolism; D002460:Cell Line; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D012760:Shigella / Q000472:pathogenicity; D037521:Virulence Factors
D000199:Actins; D001426:Bacterial Proteins; D037521:Virulence Factors