Lack of an effect of protease inhibitor use on glucose tolerance during pregnancy.
OBJECTIVE
We hypothesized that HIV-positive women on protease inhibitors (PIs) would be more likely to have an elevated glucola test result than those not on PIs.


METHODS
We reviewed our database of all HIV-positive pregnant women seen at our hospital. Serum glucose was measured 1 hour following a 50-g glucola load, at approximately 26-28 weeks of gestation. Statistical analysis was performed using Student's t-test, Fisher's exact test, and the Mann-Whitney rank sum test.


RESULTS
Forty-one HIV-infected pregnant women with glucola testing were seen between January 1, 1997 and March 1, 2000. Fourteen patients were on PIs at the time of glucola. One patient in each group had an abnormal glucola test result (glucose >/= 140 mg/dl); both had normal 3-hour glucose tolerance tests. The glucola test results were similar between the PI-exposed and unexposed, with a mean difference of 5.8 mg/dl (95% confidence interval 9.2-20.8 mg/dl). Two neonates (both exposed to PI) had hypoglycemia (glucose < 40 mg/dl).


CONCLUSIONS
The use of PIs does not significantly increase the risk of an elevated glucola result, nor is the mean glucola result increased in the women on PIs. The finding of hypoglycemia in neonates exposed to PIs merits further investigation.
Dinsmoor
Mara J
MJ
Department of Obstetrics and Gynecology, Medical College of Virginia Hospitals, Richmond, VA, USA. mdinsmoor@enh.org
Forrest
Scott T
ST
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects*; D002241:Carbohydrates; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011480:Protease Inhibitors / Q000009:adverse effects*; D019562:Viral Load
D001786:Blood Glucose; D002241:Carbohydrates; C007853:Glucola; D011480:Protease Inhibitors