[Effect of lactoferrin on the development of acute and chronic adjuvant arthritis].
An experiment revealed that the therapeutic administration of lactoferrin exerted no effect on the development of early stages of adjuvant arthritis in albino rats during chronicity. This was accompanied by decreased complement consumption and by the lower blood activity of polymorphonuclear leukocytes. The authors consider that this effect is associated with the capacity of lactoferrin to inhibit the excessive proinflammatory activity of neutrophilic leukocytes, which is characteristic of the chronicity of inflammation.
Mikhaĭlov
V P
VP
Danilov
A V
AV
Danilova
T G
TG
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002908:Chronic Disease; D003165:Complement System Proteins / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005620:Freund's Adjuvant; D007781:Lactoferrin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D051381:Rats
D003165:Complement System Proteins; D005620:Freund's Adjuvant; D007781:Lactoferrin; D010196:Pancreatic Elastase