Sensory-perceptual dysfunction in patients with schizophrenia and comorbid alcoholism.
We studied the effects of aging and comorbid alcoholism on sensory-perceptual dysfunction in patients with schizophrenia. Using sensory-perceptual tests from the Halstead-Reitan Neuropsychological Battery included in the Russell, Neuringer, and Goldstein (1970) Perceptual Disorders Index, samples were compared of 54 patients with comorbid schizophrenia and alcoholism, 234 patients with schizophrenia but no history of alcoholism, 132 patients with chronic alcoholism and 171 patient controls. Data were analyzed by one-way analyses of variance followed by Scheffe multiple comparison tests. Numerous significant differences were found among groups, with the comorbid schizophrenia group doing more poorly than the other groups on measures of touch perception and suppression, finger agnosia, and fingertip number writing. Multiple regression analyses using the sensory-perceptual tests as predictor variables and age as the dependent variable indicated that the strength of association between age and the multivariate set of sensory-perceptual test scores was greater in the comorbid schizophrenia group than the noncomorbid schizophrenia, alcoholism and patient control groups. The preponderance of age-related deficits was left-sided, suggesting accelerated decline in right hemispheric function. A comparison of groups across ages on a single Perceptual Disorders Index score showed a substantially larger age effect in the comorbid schizophrenia group relative to the other groups.
Goldstein
Gerald
G
VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA 15206, USA. ggold@nb.net
Allen
Daniel N
DN
Sanders
Richard D
RD
D000367:Age Factors; D000437:Alcoholism / Q000453:epidemiology / Q000503:physiopathology*; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000209:etiology*; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*; D012720:Severity of Illness Index