title: Origins and early development of the case-control study: Part 2, The case-control study from Lane-Claypon to 1950.
abstract: The first modern case-control study was Janet Lane-Claypon's study of breast cancer in 1926, but the design was used only sporadically in medicine and the social sciences until 1950, when four published case-control studies linked smoking and lung cancer. These 1950 studies synthesized the essential elements of the case-control comparison, produced a conceptual shift within epidemiology, and laid the foundation for the rapid development of the case-control design in the subsequent half century.
authors.affiliation: Department of Epidemiology and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA. paneth@msu.edu
authors.forename: Nigel
authors.initials: N
authors.lastname: Paneth
authors.forename: Ezra
authors.initials: E
authors.lastname: Susser
authors.forename: Mervyn
authors.initials: M
authors.lastname: Susser
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D002944:Circumcision, Male; D000013:Congenital Abnormalities / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D004813:Epidemiology / Q000266:history*; D005260:Female; D049673:History, 20th Century; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D010412:Penile Neoplasms / Q000453:epidemiology; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D006113:United Kingdom; D014481:United States