title: Topoisomerase II may be linked to the reduction of chromosome number in meiosis.
abstract: A reduction of chromosome number in meiosis is essential for genome transmission in diploid organisms. Reduction depends on a change in kinetochore configuration.1 A recent study2 connects changes in kinetochores with other changes in chromosome structure and raises the intriguing possibility that topoisomerase II, the DNA untangling enzyme, is involved.
authors.affiliation: Departments of Biology and Cell Biology, LSRC Building, Duke University, Box 91000, Durham, NC 27708, USA. LVP@duke.edu
authors.forename: Leocadia V
authors.initials: LV
authors.lastname: Paliulis
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Nicklas
mesh_terms: D000818:Animals; D002875:Chromosomes; D003078:Colchicine / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D018386:Kinetochores / Q000378:metabolism; D008540:Meiosis / Q000502:physiology*; D008954:Models, Biological
chemical_list: D004250:DNA Topoisomerases, Type II; D003078:Colchicine