title: Safety of FFR-based treatment strategies: the Munich experience.
abstract: Fractional flow reserve (FFR) as a new technique for physiological assessment of coronary stenoses could identify patients with CAD in whom the deferral of an intended PCI was more beneficial than performing the planned procedure. It is up to now unknown whether a FFR-based therapy stratification is also safe in patients with multivessel disease and complex coronary lesions. This study demonstrates in 71 symptomatic patients with predominantly multivessel disease and angiographically intermediate coronary lesions that patients do not benefit from PCI procedures in terms of overall survival, target vessel patency or clinical symptoms during 12 month follow-up if FFR is above 0.75.
authors.affiliation: Medizinische Klinik der Universität München-Innenstadt Ziemssenstr. 1 80336 München, Germany. klauss@medinn.med.uni-muenchen.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Rieber
authors.forename: Philip
authors.initials: P
authors.lastname: Jung
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Schiele
authors.forename: Andreas
authors.initials: A
authors.lastname: Koenig
authors.forename: Isabelle
authors.initials: I
authors.lastname: Erhard
authors.forename: Tobias
authors.initials: T
authors.lastname: Segmiller
authors.forename: Silke
authors.initials: S
authors.lastname: Ebel
authors.forename: Karl
authors.initials: K
authors.lastname: Theisen
authors.forename: Uwe
authors.initials: U
authors.lastname: Siebert
authors.forename: Volker
authors.initials: V
authors.lastname: Klauss
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D015607:Stents; D016019:Survival Analysis; D013997:Time Factors