title: Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma.
abstract: OBJECTIVE
  Glaucoma is a disease of the retinal ganglion cells leading to reduction of peripheral vision. It is often associated with an increase in intraocular pressure, leading to mechanical stress of tissues. The oculomedin gene is activated by such stretching and is therefore a candidate for causing glaucoma.
  
  
  METHODS
  The coding sequence and part of the promoter was screened for sequence variants in Swedish cohorts of primary open angle glaucoma, exfoliative glaucoma, and matched controls.
  
  
  RESULTS
  Only rare variants were detected in the patient material.
  
  
  CONCLUSIONS
  There was no evidence that the oculomedin gene participates in the etiology of glaucoma.
authors.affiliation: Department of Genetics and Pathology, Unit of Clinical Genetics, Uppsala University, Uppsala, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Jansson
authors.forename: Lidija
authors.initials: L
authors.lastname: Tomic
authors.forename: Lill-Inger
authors.initials: LI
authors.lastname: Larsson
authors.forename: Claes
authors.initials: C
authors.lastname: Wadelius
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D017931:DNA Primers / Q000737:chemistry; D005069:Evaluation Studies as Topic; D017889:Exfoliation Syndrome / Q000235:genetics*; D005136:Eye Proteins / Q000235:genetics*; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure; D008969:Molecular Sequence Data; D009154:Mutation; D016366:Open Reading Frames / Q000235:genetics; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D017931:DNA Primers; D005136:Eye Proteins; C119566:OCLM protein, human