Integrated approaches to therapeutic target gene discovery.
The identification of tractable drug targets is the first critical step in the long process of drug development, and the challenge for scientists in the post-genomic era is to couple gene and protein sequence information with biological insight to identify genes with the greatest therapeutic and commercial potential. An extraordinary array of genomics- and proteomics-based techniques is available for this endeavor, and combining multiple, complementary approaches enhances the informative power of such experimentation.
DeFife
Kristin M
KM
Immusol Inc, 10790 Roselle Street, San Diego, CA 92121, USA.
Wong-Staal
Flossie
F
D000818:Animals; D015870:Gene Expression; D020868:Gene Silencing; D018390:Gene Targeting / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D005826:Genetics, Medical / Q000379:methods*; D023281:Genomics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D040081:Protein Array Analysis; D040901:Proteomics