title: Dystrophin in limb skeletal muscle fibers and creatinkinase leakage after acute +3 Gz acceleration in rhesus monkeys.
abstract: Intensive muscle tension induces significant blood accumulation of enzymes and structural proteins of the muscle origin. Altered macromolecular permeability of the sarcolemma is attributed to integrity of sarcolemmal cytoskeleton, mainly to dystrophin-sarcoglycan (DSG) complex. It is known that intensive tension of the antigravity extensor muscles is observed under conditions of gravitational overloading. We assumed that acute exposure to hypergravity would lead to serum accumulation of creatine phosphokinase (CK) associated with considerably altered integrity of the dystrophin layer in fibers of extensor muscles.
authors.affiliation: State Research Center of the Russian Federation--Institute for Biomedical Problems of the Russian Academy of Sciences, Laboratory of Myology.
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: I N
authors.initials: IN
authors.lastname: Belozerova
authors.forename: T L
authors.initials: TL
authors.lastname: Nemirovskaya
authors.forename: S A
authors.initials: SA
authors.lastname: Goncharova
authors.forename: L B
authors.initials: LB
authors.lastname: Strogonova
mesh_terms: D000054:Acceleration; D000818:Animals; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism*; D016189:Dystrophin / Q000032:analysis / Q000502:physiology*; D018471:Hypergravity; D008253:Macaca mulatta; D018485:Muscle Fibers, Skeletal / Q000737:chemistry / Q000201:enzymology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000201:enzymology / Q000502:physiology*; D013049:Spectrin / Q000032:analysis / Q000502:physiology
chemical_list: D016189:Dystrophin; D013049:Spectrin; D003402:Creatine Kinase