title: A Notch so simple influence on T cell development.
abstract: T cell precursors undergo a series of developmental choices that progressively narrow their ability to give rise to different cell lineages. Evidence accumulated in the last few years suggests that Notch occupies a central place among the signal transduction pathways that regulate many of these choices, including the T/B, alphabeta/gammadelta and CD4/CD8 lineage decisions. Nevertheless the mechanisms by which Notch exerts its effects are not well understood, and in some cases the physiologic role is unclear. In this review we try to present succinctly the experiments and highlight the areas of controversy.
authors.affiliation: California Institute of Technology, Division of Biology 156-29, 1200 E California Blvd, Pasadena, CA 91125, USA.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hernández-Hoyos
authors.forename: José
authors.initials: J
authors.lastname: Alberola-Ila
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch