title: New approaches to reversal of neuromuscular block.
abstract: Although numerous reversal agents for neuromuscular block (NMB) have been known for some time, investigations on new approaches were initiated only recently. The different approaches used in an attempt to avoid the muscarinic side effects associated with the antagonists of NMB that are currently available are reviewed.
authors.affiliation: Organon Laboratories Ltd, Departments of Pharmacology and Medicinal Chemistry, Newhouse, ML1 5SH, Scotland, UK.
authors.forename: Anton
authors.initials: A
authors.lastname: Bom
authors.forename: John K
authors.initials: JK
authors.lastname: Clark
authors.forename: Ronald
authors.initials: R
authors.lastname: Palin
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D006801:Humans; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D026902:Potassium Channel Blockers; D000109:Acetylcholine