title: Osteosarcoma arising from the skull--case report.
abstract: A 20-year-old male presented with an osteosarcoma in the right parieto-occipital bone occurring as a painless occipital lump which had rapidly enlarged in the 6 months prior to admission. The neuroimaging appearance resembled intraosseous meningioma. Gross total resection of the tumor was achieved. The final histological diagnosis was osteosarcoma. Osteosarcomas of craniofacial region have a better prognosis than those of the skeletal bones, and distant metastasis is rare. Local recurrence is the most significant factor contributing to poor outcome. Complete excision with negative margins is the key to a better outcome. Adjuvant therapy may be an option in cases of incomplete excision. Advances in target chemotherapy may diminish the significant morbidity associated with these lesions.
authors.affiliation: Department of Neurosurgery, Nippon Medical School, Tokyo, Japan. ryu@nms.ac.jp
authors.forename: Ryuzaburo
authors.initials: R
authors.lastname: Kanazawa
authors.forename: Daizo
authors.initials: D
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Koshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
mesh_terms: D000328:Adult; D000792:Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008576:Meningeal Arteries / Q000000981:diagnostic imaging; D012516:Osteosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed