title: Is there a role for Notch signalling in human breast cancer?
abstract: Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
authors.affiliation: School of Biological Sciences, University of Manchester, UK. keith.brennan@man.ac.uk
authors.forename: Keith
authors.initials: K
authors.lastname: Brennan
authors.forename: Anthony M C
authors.initials: AM
authors.lastname: Brown
mesh_terms: D001943:Breast Neoplasms / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D051880:Receptors, Notch; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch