Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate.
Inosine 5'-monophosphate dehydrogenase (IMPDH; EC 1.1.1.205) isolated from Escherichia coli B3 cells was strongly inhibited by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate (2-FVIMP). Inhibition of IMPDH appears to be irreversible with k(inact) and K(i) values of 0.0269 s(-1) and 1.11 microM, respectively.
Nair
Vasu
V
Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602, USA. vnair@rx.uga.edu
Kamboj
Ramesh C
RC
D029968:Escherichia coli Proteins; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007291:Inosine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007700:Kinetics; D011489:Protein Denaturation / Q000187:drug effects; D020673:Protein Renaturation / Q000187:drug effects
C478751:2-(2-fluorovinyl)inosine 5'-monophosphate; D029968:Escherichia coli Proteins; D007291:Inosine Monophosphate; D007168:IMP Dehydrogenase