Aberrant receptor-mediated Cushing's syndrome.
Multiple alterations of G-protein-coupled receptors and G-proteins regulating intracellular transduction signal have been described in endocrine tumours. In Cushing's syndrome, aberrant or 'illicit' expression of membrane receptors (mainly G-protein-coupled receptors) has been observed in adrenal adenomas and adrenocorticotropic hormone (ACTH)-independent macronodular bilateral adrenal hyperplasia. The best characterized example to date is the aberrant expression of the gastric inhibitory polypeptide receptor that causes 'food-dependent hypercortisolism'. Aberrant expression of the luteinizing hormone, 2-adrenergic, interleukin receptors have also been reported. The level of expression of the vasopressin V1a receptor correlates with the direct (ACTH-independent) cortisol response to vasopressin.
Bertagna
Xavier
X
Service des Maladies Endocriniennes et Métaboliques, Hôspital Cochin, Paris, France. xavier.bertagna@cch.ap-hop-paris.fr
Groussin
Lionel
L
Luton
Jean-Pierre
JP
Bertherat
Jérôme
J
D000818:Animals; D003480:Cushing Syndrome / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism; D011974:Receptors, LH / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D044422:Receptors, Serotonin, 5-HT4; D017483:Receptors, Vasopressin / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011964:Receptors, Gastrointestinal Hormone; D011974:Receptors, LH; D011985:Receptors, Serotonin; D017483:Receptors, Vasopressin; D014667:Vasopressins; D044422:Receptors, Serotonin, 5-HT4; D005749:Gastric Inhibitory Polypeptide; C041086:gastric inhibitory polypeptide receptor; D006854:Hydrocortisone