title: NADPH-diaphorase-positive neurons in the auditory cortex of young and old rats.
abstract: Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young animals, as well as changes in the shape and configuration of nerve cell bodies and dendrites. Quantitative analysis demonstrated an age-related increase in the number of dendritic segments and dendritic branching points. The length of dendrites in NADPH-d-positive neurons and their density increased in very old rats. The total number of NADPH-d-positive neurons within the Te 1 and Te 3 fields was 13% lower in the old rats than in the young.
authors.affiliation: Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague.
authors.forename: L
authors.initials: L
authors.lastname: Ouda
authors.forename: F C
authors.initials: FC
authors.lastname: Nwabueze-Ogbo
authors.forename: R
authors.initials: R
authors.lastname: Druga
authors.forename: J
authors.initials: J
authors.lastname: Syka
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000201:enzymology* / Q000473:pathology; D002452:Cell Count; D003712:Dendrites / Q000648:ultrastructure; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D020318:Rats, Long-Evans; D014018:Tissue Distribution
chemical_list: D009252:NADPH Dehydrogenase