title: Treatment of lymphocytic hypophysitis by high-dose methylprednisolone pulse therapy.
abstract: A 26-year-old woman 3 months post-partum was admitted to our hospital suffering from gross visual disturbance. Magnetic resonance imaging (MRI) revealed a pituitary mass, extending into the suprasellar cistern, with intense gadolinium enhancement. Lymphocytic hypophysitis (LHy) was suspected, and the patient received high dose methylprednisolone pulse therapy (HDMPT). Her visual disturbance was dramatically ameliorated on the first day following initiation of HDMPT, and MRI revealed marked mass reduction. Her pituitary function recovered 6 months after therapy. This case report suggests that HDMPT proved effective for mass reduction of severe LHy and could obviate the need for a useless surgery.
authors.affiliation: Department of Internal Medicine, Osaka City General Hospital, Miyakojima, Osaka
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamagami
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Haruna
authors.initials: H
authors.lastname: Sakai
authors.forename: Mariko
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamakita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hosoi
authors.forename: Tomofusa
authors.initials: T
authors.lastname: Ishii
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sato
authors.forename: Shiro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujii
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000188:drug therapy; D007262:Infusions, Intravenous; D008218:Lymphocytosis / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage*; D010900:Pituitary Diseases / Q000175:diagnosis / Q000188:drug therapy*; D010901:Pituitary Function Tests; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000473:pathology; D020551:Pulse Therapy, Drug; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D008775:Methylprednisolone