The role of platelet receptors and adhesion molecules in coronary artery disease.
Platelets play a significant role in coronary artery disease through interactions with each other and with other cell types. These interactions are mediated by certain receptors on the surface of platelets and other cells which can lead to intra-coronary thrombus formation and occlusion that may result in acute coronary syndromes. The important roles of the currently available anti-platelet therapies have been well established in many clinical outcome trials in cardiovascular patients. An understanding of these different interactions provides the clinician with a background that supports the clinical importance of currently available anti-platelet therapies. Moreover, knowledge of the mechanisms of cellular crosstalk will lead to important advances in the development of better antithrombotic therapies.
Samara
Waiel M
WM
Sinai Center for Thrombosis Research, Baltimore, Maryland 21215, USA.
Gurbel
Paul A
PA
D023201:CD40 Ligand / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D019007:P-Selectin / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D039341:Receptors, Fibrinogen / Q000502:physiology; D017474:Receptors, Laminin / Q000502:physiology; D018179:Receptors, Thrombin / Q000502:physiology; D015912:Thrombolytic Therapy
D016023:Integrins; D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D010980:Platelet Membrane Glycoproteins; D039341:Receptors, Fibrinogen; D017474:Receptors, Laminin; D018179:Receptors, Thrombin; D023201:CD40 Ligand