title: Body mass index is the main risk factor for arterial hypertension in young subjects without major comorbidity.
abstract: BACKGROUND
  Analytical statistics revealed a variety of risk factors for hypertension, but the complex interplay between different factors remains to be determined by more powerful statistical techniques.
  
  
  METHODS
  Analytical as well as new, explorative statistical methods such as natural segmentation (k-means) and predictive modelling algorithms (C4.5) were used to classify the interactions of the individual risk factors for arterial hypertension in a large cohort of subjects. Fifty-five attributes (subject base, sociodemographic, medical history, laboratory data) were obtained from each of the 3547 participants of a community-based health survey. The study subjects, mean age of 41 years, were free of major comorbidity.
  
  
  RESULTS
  Twenty-five percent of the subjects had at least stage 1 hypertension. No clear linear dependency of risk factors with the diagnosis hypertension could be derived by the analytical statistics. In particular, the mutual amplification of different risk factors towards hypertension could not be revealed by these techniques. Explorative analytics however, uncovered body mass index (BMI) as the main single risk factor associated with hypertension. High predictive accuracy was achieved when combinations of certain risk factors including male gender and age were used.
  
  
  CONCLUSIONS
  In summary, the survey of risk factors for hypertension using explorative analytics yielded high increases for the correct prediction of arterial hypertension. In this cohort, BMI was the single strongest parameter associated with arterial hypertension.
authors.affiliation: Institute for Theoretical Chenistry and Molecular Structural Biology, University of Vienna, Vienna, Austria.
authors.forename: Arno
authors.initials: A
authors.lastname: Lukas
authors.forename: Friedrich
authors.initials: F
authors.lastname: Kumbein
authors.forename: Christian
authors.initials: C
authors.lastname: Temml
authors.forename: Bernd
authors.initials: B
authors.lastname: Mayer
authors.forename: Rainer
authors.initials: R
authors.lastname: Oberbauer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D012307:Risk Factors