Anti-angiogenic activity of BIM (bio-immunomodulator).
Angiogenesis and immune suppression are the two important factors responsible for embryo implantation and development of tumor. Therefore, disruption of angiogenesis and upliftment of immune function is essential for control of tumor growth as well as to regulate the activity of post coital contraceptives. BIM is an immunomodulatory cytokine obtained from rodent bone marrow that showed anti-implantation and anti-tumor activities. It also improved T/B cell and monocyte macrophage functions. In this communication the anti-angiogenic property of BIM is demonstrated in pregnant rat model. BIM induced disintegration of uterine myometrium and blood vessels. No implantation was observed compared to control. It is proposed that depending upon the physiological condition of the host BIM could modulate host immune function and exert its anti-angiogenic effect.
Ghoshal
Debasis
D
Department of Chemistry, Bose Institute, 92/1, APC Road, Calcutta 700 009, India. ghosal_deb@yahoo.co.uk
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D016207:Cytokines / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000098:blood supply / Q000187:drug effects
D000276:Adjuvants, Immunologic; D020533:Angiogenesis Inhibitors; D016207:Cytokines