title: Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation.
abstract: We present the case of a newborn male with D-transposition of the great arteries, ventricular septal defect, and subpulmonary stenosis who experienced two episodes of systemic-to-pulmonary artery shunt thrombosis. Hematologic evaluation revealed heterozygous factor V Leiden mutation. This report emphasizes the importance of evaluation for inherited coagulation disorders in pediatric patients with unexpected thrombotic complications.
authors.affiliation: Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. simsicjm@musc.edu
authors.forename: Janet M
authors.initials: JM
authors.lastname: Simsic
authors.forename: Walter E
authors.initials: WE
authors.lastname: Uber
authors.forename: John
authors.initials: J
authors.lastname: Lazarchick
authors.forename: Scott M
authors.initials: SM
authors.lastname: Bradley
mesh_terms: D000714:Anastomosis, Surgical; D025861:Blood Coagulation Disorders, Inherited / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D011651:Pulmonary Artery / Q000601:surgery*; D013927:Thrombosis / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V