[Prognostic impact of karyotype in de novo acute myeloid leukemia: study of 139 cases].
A group of 139 patients with de novo acute myeloid leukemia were investigated to determine the prognostic significance of karyotype on early death, complete remission, continuous complete remission and survival. There were 27 children and 112 adults. Mean age was 32 years. t(15;17) was found associated with a high rate of early death and a diploid karyotype with long continuous complete remission. The presence of a structural change was predictive of shorter survivals. The study of the prognostic impact of recurrent anomalies reveals a good prognostic impact for normal karyotype (1 year survival probability: 40%), followed by t(8;21) (1 year survival probability: 24%), and by t(15;17) (1 year survival probability: 9%).
Sennana Sendi
Halima
H
Service de cytogénétique et de biologie de la reproduction, CHU Farhat Hached-Sousse.
Elghezal
Hatem
H
Temmi
Henda
H
Gribaa
Moez
M
Laatiri
Adnène
A
Ben Abid
Héla
H
Ben Abdeladhime
Abdeladhime
A
Elloumi
Moez
M
Hafsia
Aicha
A
Saad
Ali
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013534:Survival