Bioactive kaurane diterpenes and coumarins from Fortunella margarita.
Two bioactive pyranocoumarins 1 (sesselin) and 3 (xanthyletin) and one prenylated coumarin 2 (suberosin), beside three rare kaurene diterpenes 5-7 were isolated from the roots of Fortunella margarita. Their structures were determined from their spectroscopic data, including 1H/13C 2D NMR experiments. The kaurene diterpenes 5-7 are reported in Rutaceae for the first time. Diterpene 5 was found to be a potent stimulator of uterine contraction; it also caused stimulation of brain activity.
el-Shafae
A M
AM
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. mahereldomiaty@hotmail.com
Ibrahim
M A
MA
D000818:Animals; D002855:Chromatography, Thin Layer; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D007275:Injections, Intravenous; D007422:Intestines / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D027821:Rutaceae / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014590:Uterine Contraction / Q000187:drug effects
D003374:Coumarins; D004224:Diterpenes; D012997:Solvents