title: Clinical parameters and treatment results in recurrent granulosa cell tumor of the ovary.
abstract: OBJECTIVE
  The objectives of this study were to evaluate the patients' characteristics and treatment results for 11 recurrent granulosa cell tumors (GCT) of the ovary.
  
  
  METHODS
  Tumor registries were screened retrospectively for all patients treated between 1979 and 1999 for ovarian tumors at the University of Istanbul. All information about these patients was obtained from operation, pathology, and follow-up reports. Then the clinical data were extracted. The patients were classified in stages according to FIGO criteria. There were 952 ovarian carcinomas, of which 45 were GCT. Eleven of 45 patients (24%) developed recurrent disease on follow-up.
  
  
  RESULTS
  All patients but one had advanced (III-IV) disease at diagnosis. The median progression-free interval (PFI) was 16 months (range, 5-39 months) with a marked difference in PFI between patients receiving (24 months) and not receiving (8 months) initial chemotherapy. Among patients received chemotherapy (six patients), two complete and two partial responses were observed, for an overall response rate of 67%. The median survival for all patients was 26 (4-73) months with a longer survival (38 versus 8 months) for patients retreated with a platinum-containing regimen.
  
  
  CONCLUSIONS
  Despite the fact that small number of treated cases does not allow an adequate evaluation, retreatment with cis-platinum-containing regimens may be the treatment of choice for patients with recurrent disease.
authors.affiliation: Department of Oncology, University of Trakya, Edirne, Turkey. kzuygun@hotmail.com
authors.forename: Kazim
authors.initials: K
authors.lastname: Uygun
authors.forename: Adnan
authors.initials: A
authors.lastname: Aydiner
authors.forename: Pinar
authors.initials: P
authors.lastname: Saip
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kocak
authors.forename: Mert
authors.initials: M
authors.lastname: Basaran
authors.forename: Maktav
authors.initials: M
authors.lastname: Dincer
authors.forename: Erkan
authors.initials: E
authors.lastname: Topuz
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy*; D012189:Retrospective Studies