title: Nucleoporin p62 antibodies in a case of mixed connective tissue disease.
abstract: Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders.
authors.affiliation: Medizinische Poliklinik, University of Wurzburg, 97070 Wurzburg, Germany. d.kraemer@medizin.uni-wuerzburg.de
authors.forename: Doris M
authors.initials: DM
authors.lastname: Kraemer
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kraus
authors.forename: Christian
authors.initials: C
authors.lastname: Kneitz
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Tony
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D008947:Mixed Connective Tissue Disease / Q000276:immunology*; D028861:Nuclear Pore Complex Proteins; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D008562:Membrane Glycoproteins; D028861:Nuclear Pore Complex Proteins; C049312:nuclear pore protein p62