[Metabolic interactions between glucose and fructose].
Fructose-1-phosphate, the product of fructose phosphorylation by fructokinase, favours glucose phosphorylation by glucokinase, at the intervention of a regulatory protein. Glucose confers to glucokinase positive cooperativity, towards fructose. These reciprocal effects are operative in hepatocytes and pancreatic islets. They could optimize their glucostatic function.
Malaisse
W J
WJ
D005632:Fructose / Q000378:metabolism*; D005636:Fructosephosphates / Q000378:metabolism; D005941:Glucokinase / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D007700:Kinetics; D010766:Phosphorylation
D005636:Fructosephosphates; C032284:fructose-1-phosphate; D005632:Fructose; D005941:Glucokinase; D005947:Glucose