Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice.
The role of brain histamine on seizure development of pentylenetetrazol (PTZ)-induced kindling was examined in H(1)-receptor gene knockout (H(1)KO), histidine decarboxylase-deficient (HDC(-/-)) and mast cell-deficient (W/W(v)) mice. All H(1)KO, HDC(-/-) and W/W(v) mice had accelerated seizure development of PTZ-induced kindling when compared to their respective wild-type mice. The daily PTZ-kindling increased histamine content in the cortex and diencephalon of H(1)KO mice, whereas the histamine content in the diencephalon of W/W(v) mice was decreased. The present study indicates that histamine plays a suppressive role in seizure development through H(1)-receptors.
Chen
Zhong
Z
Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, 980-8575, Sendai, Japan.
Li
Zhengyan
Z
Sakurai
Eiko
E
Izadi Mobarakeh
Jalal
J
Ohtsu
Hiroshi
H
Watanabe
Takeshi
T
Watanabe
Takehiko
T
Iinuma
Kazuie
K
Yanai
Kazuhiko
K
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry; D003292:Convulsants / Q000008:administration & dosage / Q000009:adverse effects*; D006632:Histamine / Q000032:analysis; D006640:Histidine Decarboxylase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000009:adverse effects*; D011969:Receptors, Histamine H1 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D018709:Statistics, Nonparametric
D003292:Convulsants; D011969:Receptors, Histamine H1; D006632:Histamine; D006640:Histidine Decarboxylase; D010433:Pentylenetetrazole