Antiviral flavonoids from the root bark of Morus alba L.
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods.
Du
Jiang
J
Department of Biology and Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China.
He
Zhen-Dan
ZD
Jiang
Ren-Wang
RW
Ye
Wen-Cai
WC
Xu
Hong-Xi
HX
But
Paul Pui-Hay
PP
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests / Q000379:methods; D031625:Morus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014709:Vero Cells
D000998:Antiviral Agents; D005419:Flavonoids; D000212:Acyclovir