Interfacial interactions between amphiphilic cyclodextrins and physiologically relevant cations.
The compression isotherms of a series of amphiphilic cyclodextrins, formed (a) by acylation at the secondary hydroxyl face and (b) by acylation accompanied by varying degrees of sulfatation (DS) at the primary hydroxyl face (DS=0, 4, and 7), have been studied on subphases of pure water and of water containing NaCl, KCl, MgCl(2), and CaCl(2) at inter- and extracellular concentrations. The formation of solid lipid nanoparticles (SLNs) by two of the molecules has been observed, while these do not aggregate at concentrations of monovalent salts up to 150 mM for the sulfated derivative. In the presence of divalent salts one of these with a DS=0 for sulfatation degree flocculates at divalent salt concentrations below 0.1 mM while the other with a DS=4 flocculates at Mg(2+) concentration above 5 mM and a Ca(2+) concentration above 3 mM. AFM noncontact mode imaging has been carried out, in air, for the SLNs deposited on mica.
Dubes
Alix
A
Synthèse, Reconnaissance, Organisation Moléculaire et Biomoléculaire, CNRS UMR 5078, Université Claude Bernard Lyon 1, Bât J. Raulin, 43, Bd. du 11 novembre 1918, 69622 Villeurbanne cedex, France.
Parrot-Lopez
Hélène
H
Shahgaldian
Patrick
P
Coleman
Anthony W
AW
D002412:Cations / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D021241:Spectrometry, Mass, Electrospray Ionization; D013816:Thermodynamics
D002412:Cations; D003505:Cyclodextrins