Effect of fish oil on mitochondrial respiration in isoproterenol induced myocardial infarction in rats.
Following isoproterenol treatment mitochondrial lipid peroxidation, phosphoslipase activity, lactate and calcium increased significantly, while activities of tricarboxylic acid cycle enzymes, enzymes of respiratory chain and ATP production showed decline. Oxidative phosphorylation was also affected on isoproterenol treatment with significant reduction in all the variables. Fish oil pretreatment in isoproterenol treated rats showed improved mitochondrial energy metabolism. The results suggest cardioprotective effect of fish oil.
Padma
V Vijaya
VV
Department of Biochemistry & Molecular Biology, Guindy Campus, University of Madras, Chennai 600 025, India.
Devi
C S Shyamala
CS
D000818:Animals; D005395:Fish Oils / Q000494:pharmacology*; D007545:Isoproterenol / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000178:diet therapy / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D005395:Fish Oils; D007545:Isoproterenol