Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling.
Hematopoiesis is a complex process in which mature myeloid and lymphoid cells are produced from a small population of pluripotent stem cells within the bone marrow. Blood cell formation occurs, in part, by progenitor cell exposure to humoral growth regulators, known as hematopoietic cytokines, as well as by the regulated expression of genes by transcription factors. In this paper, we review two important nuclear proteins, the serum response factor and the cyclic adenosine monophosphate response element-binding protein, as downstream targets of mitogens, with a specific focus on hematopoietic cytokine signaling and the role these proteins play in gene regulation.
Mora-Garcia
Patricia
P
Department of Pediatrics, Division of Hematology-Oncology, Mattel Children's Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Cheng
Jerry
J
Crans-Vargas
Heather N
HN
Countouriotis
Athena
A
Shankar
Deepa
D
Sakamoto
Kathleen M
KM
D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D038042:Myelopoiesis / Q000502:physiology*; D026362:Serum Response Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology
D017362:Cyclic AMP Response Element-Binding Protein; D016207:Cytokines; D026362:Serum Response Factor