Molecular mechanisms of renal development.
The biology of renal development has become increasingly complex because technical advances in genetics and cell biology have been used to study this aspect of embryogenesis. The molecular biology and genetics of renal development may seem inconsequential and frustrating to the practicing clinician, but insight into fundamental mechanisms of renal development are necessary to understand clinical breakthroughs that will occur in the future. As a basis for appreciating these concepts, specific paradigms of renal development are illustrated and the investigative strategies used to develop them are summarized in this article.
Kim
Chong Min
CM
Division of Pediatric Urology, State University of New York, Downstate Medical Center, 450 Clarkson Ave (Box 79), Brooklyn, NY 11203, USA. jcmkim@hotmail.com
Glassberg
Kenneth I
KI
D000818:Animals; D029721:Drosophila Proteins; D019476:Insect Proteins / Q000502:physiology; D007668:Kidney / Q000196:embryology*; D008565:Membrane Proteins / Q000235:genetics; D008967:Molecular Biology; D009414:Nerve Growth Factors / Q000502:physiology; D020890:Neuregulin-1 / Q000502:physiology; D007690:Polycystic Kidney Diseases / Q000235:genetics; D011506:Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; D015398:Signal Transduction / Q000502:physiology; D050396:TRPP Cation Channels; D014402:Tuberous Sclerosis / Q000235:genetics; D025721:WT1 Proteins / Q000502:physiology; D006623:von Hippel-Lindau Disease / Q000235:genetics
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009414:Nerve Growth Factors; D020890:Neuregulin-1; D011506:Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; D050396:TRPP Cation Channels; D025721:WT1 Proteins; C416649:Ret protein, Drosophila