Treatment with sildenafil for the healing of refractory skin ulcerations in the antiphospholipid syndrome.
Nonhealing skin ulceration is a cutaneous manifestation of the antiphospholipid syndrome (APS) and is associated with thrombosis of small dermal vessels. Numerous therapies have been described but are either ineffective or require a prolonged course of treatment with potential complications. We describe the efficacy of sildenafil, a phosphodiesterase inhibitor, in the treatments of such ulcers.
Gertner
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University of Minnesota Medical School and Section of Rheumatology, Regions Hospital, St Paul, Minnesota, USA.
D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D012883:Skin Ulcer / Q000150:complications / Q000188:drug therapy*; D013450:Sulfones; D014945:Wound Healing / Q000187:drug effects*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate