TNFB polymorphism may be associated with schizophrenia in the Korean population.
This study was conducted to test the association between the tumor necrosis factor (TNF)-beta gene (B) polymorphism and schizophrenia in the Korean population. 127 patients with schizophrenia according to the DSM-IV criteria and 202 healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex-matched native Koreans. Genotyping for the TNFB polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFB polymorphism in patients with schizophrenia were significantly different from those of the controls. Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population.
Jun
Tae-Youn
TY
Department of Psychiatry, College of Medicine, The Catholic University of Korea, St. Mary's Hospital, 62 Yoido-Dong, Youngdeungpo-Gu, Seoul, 150-713, South Korea.
Pae
Chi-Un
CU
Chae
Jeong-Ho
JH
Bahk
Won-Myong
WM
Kim
Kwang-Soo
KS
Han
Hoon
H
Serretti
Alessandro
A
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D015870:Gene Expression / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D008233:Lymphotoxin-alpha