New approaches to reversal of neuromuscular block.
Although numerous reversal agents for neuromuscular block (NMB) have been known for some time, investigations on new approaches were initiated only recently. The different approaches used in an attempt to avoid the muscarinic side effects associated with the antagonists of NMB that are currently available are reviewed.
Bom
Anton
A
Organon Laboratories Ltd, Departments of Pharmacology and Medicinal Chemistry, Newhouse, ML1 5SH, Scotland, UK.
Clark
John K
JK
Palin
Ronald
R
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D006801:Humans; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D026902:Potassium Channel Blockers; D000109:Acetylcholine