[Endobronchial brachytherapy: technique and indications].
The endobronchial brachytherapy procedure involves the insertion of an afterloading catheter into bronchus in close proximity to an endoluminal lesion, and to perform limited irradiation sparing as much as possible normal health tissues. The catheter is inserted during a classical flexible bronchoscopy. Three types of indications have been discussed: (i) palliative treatment of lung carcinoma, with or without laser desobstruction: an improvement in respiratory symptoms was observed in 60 to 80% of the cases; (ii) curative treatment for localised endobronchial carcinomas, in previously irradiated patients, or in case of contraindication of surgery or external beam irradiation; local control rate range from 60 to 70% at 2 years; (iii) combination of external irradiation and brachytherapy in the first line treatment of lung cancers. Two randomised trials did not show any improvement in survival for this approach; however, they have included advanced diseases. In the opposite, this association seems very effective for early stage lung carcinomas. Two major complications were regularly reported, haemoptysis and radiation bronchitis. Predictive factors for these toxicities are actually better known: haemoptysis could be due to a progressive disease more often than to brachytherapy itself; technical factors (dose, volume, fractionation), however, could explain a number of radiation bronchitis, and their incidence could decrease in the future.
Hennequin
C
C
Services de cancérologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010, Paris, France. christophe.hennequin@sls.ap-hop-paris.fr <christophe.hennequin@sls.ap-hop-paris.fr>
Bleichner
O
O
Trédaniel
J
J
Maylin
C
C
D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D001980:Bronchi; D001983:Bronchial Fistula / Q000209:etiology; D002283:Carcinoma, Bronchogenic / Q000532:radiotherapy; D019583:Dose Fractionation, Radiation; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D010166:Palliative Care; D017564:Radiation Pneumonitis / Q000209:etiology; D014138:Tracheoesophageal Fistula / Q000209:etiology; D016896:Treatment Outcome