Copper-catalyzed regioselective allylic substitution reactions with indium organometallics.
The first nucleophilic allylic substitution reactions of triorganoindium compounds with allylic halides and phosphates are reported. The reactions of trialkyl- and triarylindium reagents with cinnamyl and geranyl halides and phosphates, with the aid of copper catalysis [Cu(OTf)(2)/P(OEt)(3)], are described. In general, the reaction proceeds efficiently to give good yields and regioselectively to afford the S(N)2' product.
Rodríguez
David
D
Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain.
Sestelo
José Pérez
JP
Sarandeses
Luis A
LA