[Structure and function of PDGF-R-alpha and its expression in normal kidney and kidney diseases].
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. There is a difference in binding affinity of various forms of PDGF by these receptors. Two different promotors P1 and P2 can be used for PDGF-alpha R gene transcription. There are several different haplotypes of promotor P1 sequence. Transcription of PDGF-alpha R gene is under control of many factors. Interaction between a receptor and its ligand includes receptor dimerisation and autophosphorylation of tyrosine residues. PDGF AA is unique in that it can only be bound by alpha-receptor dimer. PDGF-AA expression has been confirmed in the normal kidney, as well as in several renal diseases. Although the expression of PDGF-alpha R has been found to accompany that of PDGF-AA, its actual relevance for the development of the glomerular pathology is not clear.
Miller-Kasprzak
Ewa
E
Pracownia Nefrologii Molekularnej Katedry i Kliniki Nefrologii Akademii Medyczne w Poznaniu.
Niemir
Zofia I
ZI
Czekalski
Stanisław
S
D005786:Gene Expression Regulation; D005921:Glomerulonephritis / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011110:Polymorphism, Genetic; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*; D015398:Signal Transduction
D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; C411423:platelet-derived growth factor C; D020796:Receptor, Platelet-Derived Growth Factor alpha