Comparative study of serum lipids and serum lipoprotein spectrum in patients with cerebrovascular diseases.
OBJECTIVE
To investigate the differences of serum lipids and serum lipoprotein spectrum between patients with cerebral hemorrhage (CH) and cerebral infarction (CI), and study their features of expression in the 2 cerebral conditions.


METHODS
Serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very-low-density lipoprotein cholesterol (vLDLC), low-density lipoprotein cholesterol (LDLC) and serum lipoprotein electrophoretogram were determined in 59 CI and 21 CH patients as well as in 30 normal subjects.


RESULTS
CI patients had higher levels of TC, LDLC, alpha-lipoprotein (alpha LP), beta-lipoprotein (beta LP) and intermediate-density beta-lipoprotein (int beta LP) than the normal subjects, and the CH patients had lower LDLC level than the CI patients. The CH patients had also higher levels of beta LP, int beta LP and LDLC than the normal subjects. Progressive regression analysis was performed and resulted in the selection of beta LP, int beta LP and HDLC as the best discriminators for cerebral vascular diseases, which were valid in classifying 71.3% of the cases included in this study.


CONCLUSIONS
beta LP, int beta LP and HDLC are important clinical indicators to predict cerebral vascular diseases.
Zhou
Juan
J
Faculty of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515. jiangzj@fimmu.com
Zhang
Min
M
Li
Xiao-min
XM
D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood*; D002544:Cerebral Infarction / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D017270:Lipoprotein(a); D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides