[Mechanisms of large artery remodeling].
Degenerative changes of elastin, increase of collagen fibres, proliferation of muscle cells and impairment in endothelium function occurs in the vessel wall with ageing, in hypertensive and others diseases. Early changes are potentially reversible. Atherosclerosis is a late stage of pathologies occurring in the arterial wall in response to various factors. The present paper describes current knowledge on mechanisms of arterial wall remodelling. The authors define basic indices of arterial compliance and describe several physiological and pathological factors which occur play the main role in process of arterial wall remodelling. A chapter is devoted to the effects of increased arterial stiffness on heart pathology and clinical implications of measuring these parameters.
Cwynar
Marcin
M
Katedra Chorób Wewnetrznych i Gerontologii Collegium Medicum, Uniwersytetu Jagiellońskiego, 31-531 Kraków, ul. Sniadeckich 10.
Wojciechowska
Wiktoria
W
Kawecka-Jaszcz
Kalina
K
Grodzicki
Tomasz
T
D000367:Age Factors; D000375:Aging; D001158:Arteries / Q000473:pathology* / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D004547:Elastic Tissue / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology*; D020257:Ventricular Remodeling