The impact of the paper of Edsall and Mehl (1940) on actin and actomyosin research.
The paper of Edsall and Mehl, 'The effect of denaturing agents on myosin, II. Viscosity and double refraction of flow', J. Biol. Chem. 133 (1940) 409-429, inspired our research on actin and actomyosin. It led to the specific purification of actin with magnesium ions and to the demonstration of the central role of the Mg(2+)-activated actomyosin ATPase in contraction of live muscle.
Bárány
Michael
M
Department of Biochemistry and Molecular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA. mbarany@uic.edu
Bárány
Kate
K
D000199:Actins / Q000266:history* / Q000502:physiology; D000205:Actomyosin / Q000266:history* / Q000502:physiology; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001671:Biochemistry / Q000266:history; D049673:History, 20th Century; D008274:Magnesium / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology
D000199:Actins; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D008274:Magnesium