title: [Effect of the antibodies to gangliosides on the Retzius neuron electrical activity and the functional activity of sodium channels for incoming current in leech].
abstract: In the present study, the effect of antibodies to gangliosides on the Retzius neurons of the leech was investigated to study the spike activity and the functional activity of the Na-channels which generate the spike. A forty-minute incubation of the Retzius neurons in a 20% solution of antiganglioside serum in a Ringer solution provoked appearance of a double spike (a spike with two parts) connected with a decrease of the speed of the activation of the tetrodotoxin (TTX)-sensitive Nachannels. The high frequency synaptic activation of the neuron (10 Hz during 10 minutes) under the plasticity exchange of the gate system of the TTX-sensitive Na-channels. As a result of this, there was a disturbance of the habituation of the Retzius neuron to the high-frequency stimulation.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Sergeeva
authors.forename: E
authors.initials: E
authors.lastname: Zaprianova
authors.forename: O S
authors.initials: OS
authors.lastname: Sotnikov
authors.forename: D
authors.initials: D
authors.lastname: Deleva
authors.forename: A
authors.initials: A
authors.lastname: Fil'chev
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007865:Leeches / Q000276:immunology / Q000502:physiology*; D009474:Neurons / Q000276:immunology / Q000502:physiology*; D011817:Rabbits; D015222:Sodium Channels / Q000187:drug effects / Q000276:immunology / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D005732:Gangliosides; D007106:Immune Sera; D015222:Sodium Channels