title: Atypical glandular cells of undetermined significance. Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions.
abstract: OBJECTIVE
  To verify the cytologic predictive value of a diagnosis of atypical glandular cells of undetermined significance (AGUS) in high grade squamous intraepithelial lesions (HSIL) cases.
  
  
  METHODS
  In a retrospective study, 98 cases of HSIL were reviewed. All patients were referred for colposcopy and directed biopsy to confirm the cytologic diagnoses. Loop excision of the transformation zone was performed to treat clinical lesions. Sensitivity, specificity, positive and negative predictive value were evaluated. Kappa statistics and logistic regression analysis were used to evaluate the findings statistically.
  
  
  RESULTS
  By logistic regression analysis, we found that the chance of finding squamous intraepithelial lesions involving glands in AGUS smears was 5.32 times higher than in those with no AGUS. It was 5.74 times higher in cervical intraepithelial neoplasia (CIN) 3 lesions than in CIN 2.
  
  
  CONCLUSIONS
  The cytologic predictive value for HSIL involving glands is statistically significant when specific and objective criteria are used for the AGUS diagnosis.
authors.affiliation: Departments of Gynecology and Pathology, Federal Univesity of São Paulo-Escola Paulista de Medicina, São Paulo, Brazil. gmattosinho@uol.com.br
authors.forename: Maria Da Gloria
authors.initials: Mda G
authors.lastname: Mattośinho de Castro Ferraz
authors.forename: José
authors.initials: J
authors.lastname: Focchi
authors.forename: João Norberto
authors.initials: JN
authors.lastname: Stavale
authors.forename: Sérgio Mancini
authors.initials: SM
authors.lastname: Nicolau
authors.forename: Geraldo
authors.initials: G
authors.lastname: Rodrigues de Lima
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology*; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology*