Local immunological markers of different rate of growth of uterine myoma.
The aim of our work was to establish the peculiarities of phenotype profile and functional activity of peritoneal immunocompetent cells of women with different rate of myoma growth. Forty three women with uterine myoma (main group) and 16 healthy women (control group) were recruited for study. According to the growth rate and tumor's size the main group was divided into two clinical subgroups: (1) women with stable small size of uterine myoma (23 patients), (2) women with large size rapidly growing myoma (20 patients). The expression of CD markers on the surface of peritoneal fluid (PF) lymphocytes and bactericidal and adhesive activity of macrophages were studied. It was found that in women with stable small myomas both lymphocytes and macrophages in PF were activated. In women with rapidly growing large myomas cellular reactions seemed to be inhibited and the impairment of maturation and differentiation of lymphocytes was observed. It can be suggested that local immune response is directly connected with the rate of myoma growth.
Malyshkina
Anna I
AI
V.N. Gorodkov Scientific-Research Institute of Maternity and Childhood, Ivanovo, Russia.
Posiseeva
Lubov V
LV
Sotnikova
Natalia Yu
NY
Antsiferova
Julia S
JS
Suvorkina
Elena E
EE
Arevadze
Irina E
IE
D015415:Biomarkers; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007889:Leiomyoma / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D010529:Peritoneal Cavity / Q000473:pathology; D014594:Uterine Neoplasms / Q000276:immunology*
D015415:Biomarkers