title: Long saphenous vein stripping reduces local level of reactive oxygen metabolites in patients with varicose disease of the lower limbs.
abstract: Long saphenous vein (LSV) stripping is the most common surgical procedure in patients affected by varicose disease of the lower limbs. Reactive oxygen metabolites (ROM) generation plays a crucial role in chronic venous insufficiency (CVI). The aim of this study was to investigate whether ROM generation is increased in patients affected by varicose disease versus healthy controls and whether LSV stripping has a positive effect on the local production of ROM. The local production of ROM was assessed measuring hydroperoxides in the blood collected from the leg of 30 patients consecutively undergoing LSV stripping and 30 controls. In both the patient group and the control group, the test was repeated 30 days later. We found that ROM levels before surgery are higher in varicose vein patients than in controls ( p <.0001) and that ROM are significantly reduced 30 days after LSV stripping ( p <.0001). At that time point, no significant differences between patients and controls was found. We also found that sex and age do not affect ROM concentration in patients and controls, either before or after surgery. In conclusion, our data indicate that CVI is characterized by significant oxidative stress and that LSV stripping is able to normalize local production of ROM in patients with varicose disease of the lower limbs. We suggest that measurement of ROM might be useful to test the positive effects of LSV stripping in these patients.
authors.affiliation: Department of Medicine, A. Gemelli University Hospital, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy. angiologia@rm.unicatt.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Flore
authors.forename: Angelo
authors.initials: A
authors.lastname: Santoliquido
authors.forename: Dal Lago
authors.initials: DL
authors.lastname: Antonio
authors.forename: Enrico
authors.initials: E
authors.lastname: Pola
authors.forename: Andrea
authors.initials: A
authors.lastname: Flex
authors.forename: Roberto
authors.initials: R
authors.lastname: Pola
authors.forename: Marco Gallinella
authors.initials: MG
authors.lastname: Muzi
authors.forename: Attilio
authors.initials: A
authors.lastname: Farinon
authors.forename: Francesco
authors.initials: F
authors.lastname: Rulli
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaetani
authors.forename: Paolo
authors.initials: P
authors.lastname: Tondi
authors.forename: Laura
authors.initials: L
authors.lastname: Gerardino
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012501:Saphenous Vein / Q000601:surgery*; D014648:Varicose Veins / Q000378:metabolism* / Q000601:surgery; D014656:Vascular Surgical Procedures / Q000379:methods*; D014689:Venous Insufficiency / Q000378:metabolism* / Q000601:surgery
chemical_list: D017382:Reactive Oxygen Species