title: The design and synthesis of selective prostaglandin analogs as bone anabolic agents for the potential treatment of osteoporosis.
abstract: A series of prostaglandins selective for the human FP receptor have been synthesized and evaluated as potential therapeutics for the treatment of osteoporosis. The compounds proved to be potent (nanomolar binding affinity) and selective (> 100x) ligands for the human FP receptor in vitro, and increased bone volume in the ovariectomized rat in vivo.
authors.affiliation: Procter and Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040-9317, USA.
authors.forename: David Lindsey
authors.initials: DL
authors.lastname: Soper
authors.forename: Yili
authors.initials: Y
authors.lastname: Wang
authors.forename: Biswanath
authors.initials: B
authors.lastname: De
authors.forename: Mitchell Anthony
authors.initials: MA
authors.lastname: deLong
authors.forename: Michelle Jeanine
authors.initials: MJ
authors.lastname: Dirr
authors.forename: Michele Elaine
authors.initials: ME
authors.lastname: Soehner
authors.forename: Mark Walden
authors.initials: MW
authors.lastname: Lundy
authors.forename: Glen Edward
authors.initials: GE
authors.lastname: Mieling
authors.forename: John August
authors.initials: JA
authors.lastname: Wos
mesh_terms: D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D010024:Osteoporosis / Q000188:drug therapy*; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D011461:Prostaglandins F, Synthetic; D011465:Prostaglandins, Synthetic; C006326:fluprostenol