Breastfeeding does not pose any additional risk of immunoprophylaxis failure on infants of HBV carrier mothers.
Whether babies born to hepatitis B (HB) carrier mothers with HB immunoprophylaxis at birth can be breastfed safely is controversial. A total of 230 such babies were followed up for one year to assess the influence of feeding method on the efficacy of HB immunoprophylaxis. The positive rates of anti-HBs at different ages are not statistically different between the breastfed group and the bottle-fed group. At 1 year, the rate was 80.9% in the breastfed group and 73.2% in the bottle-fed group in infants with HB vaccine alone, and 90.9% in the breastfed group and 90.3% in the bottle-fed group in infants with HBIG plus HB vaccine. There were no significant differences in the incidence of immunoprophylaxis failure between breastfed and bottle-fed babies. The results indicated that breastfeeding does not have a negative influence on the response of anti-HBs and on the failure rates of immunoprophylaxis in the infants born to HB carrier mothers.
Wang
J S
JS
Department of Infectious Disease, Children's Hospital, Fudan University, Shanghai, China.
Zhu
Q R
QR
Wang
X H
XH
D001903:Bottle Feeding; D001942:Breast Feeding; D005260:Female; D005500:Follow-Up Studies; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000151:congenital / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D017211:Treatment Failure
D017325:Hepatitis B Vaccines