Therapeutic angiogenesis by gene transfer in critical limb and myocardial ischemia.
Cardiovascular atherosclerotic diseases remain leading causes of morbidity and mortality in the world. Despite the significant progress that has been made in the management of these diseases using medical, surgical and percutaneous therapies over the last three decades, there remains a significant population of patients who are not optimal candidates for surgical or percutaneous revascularization. Substantial research has focused on the administration of angiogenic growth factors, either as recombinant protein or by gene transfer, to promote the development of supplemental collateral blood vessels that will constitute endogenous bypass conduits around occluded native arteries; a strategy termed "therapeutic angiogenesis". While many cytokines have angiogenic activity, the best studied both in animal models and clinical trials are vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). This review will discuss gene transfer strategies for therapeutic angiogenesis in critical limb and myocardial ischemia.
Schratzberger
Peter
P
Department of Internal Medicine, Division of General Internal Medicine, University Hospital Innsbruck, Innsbruck, Austria. peter.schratzberger@uibk.ac.at
Kirchmair
Rudolf
R
Vale
Peter R
PR
Losordo
Douglas W
DW
D020533:Angiogenesis Inhibitors / Q000235:genetics* / Q000627:therapeutic use*; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology* / Q000628:therapy*; D016207:Cytokines / Q000235:genetics* / Q000627:therapeutic use*; D005121:Extremities / Q000098:blood supply*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000009:adverse effects* / Q000706:statistics & numerical data; D006801:Humans; D007511:Ischemia / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D018919:Neovascularization, Physiologic / Q000235:genetics*; D011817:Rabbits; D051381:Rats
D020533:Angiogenesis Inhibitors; D016207:Cytokines