title: Autonomic system activity and 24-hour blood pressure variations in subjects with normal- and high-tension glaucoma.
abstract: OBJECTIVE
  As suggested by findings of abnormal responses to posture in patients with normal-tension glaucoma (NTG), cardiovascular autoregulation may also be defective in primary open-angle glaucoma (POAG).
  
  
  METHODS
  Both 24-hour ambulatory blood pressure monitoring and the head-up tilt test were performed in 17 subjects with NTG and in 13 subjects with high-tension POAG (ht-POAG). These groups were compared with 17 age-matched healthy individuals. Subjects undergoing cardiovascular therapy were excluded.
  
  
  RESULTS
  No significant differences in diurnal and nocturnal blood pressure and heart rate were found between the groups. A significant reduction in diurnal heart rate variability was found in NTG (12.1 +/- 2.8 bpm) compared with the ht-POAG (15.0 +/- 2.4 bpm, P < 0.01) and control groups (15.8 +/- 3.0 bpm, P = 0.01]). Nocturnal diastolic blood pressure variability was also reduced in NTG (6.9 +/- 2.2 mm Hg) compared with controls (8.6 +/- 2.3 mm Hg, P < 0.05]) as was heart rate variability (6.3 +/- 1.4 vs 8.3 +/- 2.6 in ht-POAG, P < 0.05), suggesting blunted blood pressure and heart rate modulation in NTG subjects. Spectral analysis of short-term heart rate variability showed a significant reduction of total power in the supine position (1064 +/- 600 in NTG vs 1688 +/- 889 ms2 in controls, P < 0.05]). This was not accompanied either by a physiological reduction in total power or in a high-frequency component during the passive orthostatic stimulus. These differences tend to become more prominent in the clinically more severe forms of NTG (as identified by scores based on the extent of optic disk excavation, visual field damage, and progression of disease). This would suggest a correlation between the extent of autonomic disorder and severity of glaucoma. The alpha index (root-square of low-frequency heart rate to low-frequency blood pressure ratio) was lower in the supine position in NTG subjects (8.1 +/- 3.1 vs 10.6 +/- 3.3 ms/mm Hg in controls, P < 0.05), confirming the reduced baroreflex sensitivity.
  
  
  CONCLUSIONS
  The results confirm the hypothesis that dysfunction of autonomic control of the cardiovascular response may be a contributing pathogenetic factor in NTG, inducing a chronic ischemia of the optic nerve.
authors.affiliation: Department of Scienze Biomediche e Chirurgiche, Medicina Interna C, OC Mantova, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Riccadonna
authors.forename: Grazia
authors.initials: G
authors.lastname: Covi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pancera
authors.forename: Barbara
authors.initials: B
authors.lastname: Presciuttini
authors.forename: Silvia
authors.initials: S
authors.lastname: Babighian
authors.forename: Sergio
authors.initials: S
authors.lastname: Perfetti
authors.forename: Luciano
authors.initials: L
authors.lastname: Bonomi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lechi
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016683:Supine Position; D018667:Tilt-Table Test