Cardiovascular diseases: new insights from knockout mice.
Knockout (KO) mice models have generated a wealth of new information on the developmental and physiopathological roles of several hormones and their receptors. In these mice, KO of a specific gene can be lethal at embryonic stages or during early adulthood. Furthermore, in conditions of non-lethality, KO mice may compensate for the repression of a particular protein expression. As a result of these two aspects, various phenotypic expressions occur in KO mice models for several peptides and their respective receptors, as well as for the enzymes involved in their processing.
D'Orléans-Juste
Pedro
P
Department of Pharmacology, Medical School Institut de pharmacologie de Sherbrooke Université de Sherbrooke 3001, 12th Avenue, North, Québec J1H 5N4, Sherbrooke, Canada. pedro.dorleans-juste@usherbrooke.ca
Honoré
Jean-Claude
JC
Carrier
Emilie
E
Labonté
Julie
J
D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics* / Q000502:physiology