title: Neuroradiologic and clinical abnormalities in dementia of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease).
abstract: We describe a characteristic dementia patient diagnosed as diffuse neurofibrillary tangles with calcification (DNTC). Neuropsychologically, dementia, including a decline in memory retention and intelligence, and anomic aphasia were recognized. Imaging revealed circumscribed temporal dominant atrophy and calcification of the basal ganglia and cerebellum. SPECT and FDG-PET revealed a remarkable reduction of blood flow and metabolism in the temporal lobes; however, there is no reduction in the basal ganglia and cerebellum, and FDOPA-PET also disclosed no abnormalities. This suggests that calcification and neuronal degeneration occur independently in DNTC.
authors.affiliation: Department of Neurology, Higashinagoya National Hospital, 5-101 Umemorizaka, Meito-ku, Nagoya, 465-8620, Aichi, Japan. yasuhiro.ito@mail.uni_wuerzburg.de
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.forename: Tomomi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yokokawa
authors.forename: Ikuko
authors.initials: I
authors.lastname: Aiba
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Arahata
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ito
authors.forename: Kengo
authors.initials: K
authors.lastname: Ito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D000368:Aged; D000849:Anomia / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D003704:Dementia / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology; D016874:Neurofibrillary Tangles; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed