Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice.
Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs increased. In addition, examination of the tumor rejection effect of D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is inhibited completely by activating CD4(+) T cells and CD8(+) T cells.
Harada
Nachi
N
Department of Microbial Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyama-kitamachi, Higashinada-ku, 658-8558, Kobe, Japan.
Kodama
Noriko
N
Nanba
Hiroaki
H
D000363:Agaricales / Q000737:chemistry; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D018417:Th1 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*; D013997:Time Factors
D000951:Antigens, Neoplasm; D010936:Plant Extracts