Individual fatty acids influence cultured human liver cells differently when compared to plant oils.
Most work to date using fatty acids and cultured cells has concentrated on single fatty acids, yet cells in vivo are exposed to fatty acid combinations in the form of triacylglycerols and phosphoglycerides. We have quantitated the influence of the individual fatty acids that make up three plant oils, as well as the plant oils themselves, on the growth of normal and transformed human liver cell lines. The effects of the individual fatty acids were then combined in proportion to their concentration in each plant oil and compared to the effects of the intact oils. The oils initially induced synergistic effects with low concentrations, but with high concentrations competitive effects were shown, when compared to the combined effects of the individual fatty acids.
Davidson
Bruce C
BC
University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, South Africa.
Girao
Luis A F
LA
Giangregorio
Alfredo
A
D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D005228:Fatty Acids, Essential / Q000494:pharmacology; D006801:Humans; D019787:Linoleic Acid / Q000494:pharmacology; D008041:Linoleic Acids; D008043:Linseed Oil / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008113:Liver Neoplasms / Q000473:pathology; D031665:Oenothera biennis; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D017962:alpha-Linolenic Acid / Q000494:pharmacology; D017965:gamma-Linolenic Acid / Q000494:pharmacology
D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010938:Plant Oils; D017962:alpha-Linolenic Acid; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D008043:Linseed Oil; D019787:Linoleic Acid