title: Plasma cell granuloma--an enigmatic lesion: description of an extensive intracranial case and review of the literature.
abstract: We present an unusual case of intracranial plasma cell granuloma in a 70-year-old man with a 6-month history of progressive visual disturbance. The lesion extensively involved the cranial base, extended into the frontal region, and reached the floor of the third ventricle in the suprasellar area. Microscopic examination of multiple diagnostic transsphenoidal biopsies showed an inflammatory proliferation with a predominance of cells that were immunohistochemically determined to be polyclonal plasma cells. Ultrastructural analysis confirmed the presence of numerous mature plasma cells in a mixed inflammatory proliferation. In situ hybridization for Epstein-Barr viral RNA revealed no evidence of viral expression. The patient was treated with steroid therapy and radiotherapy, without any appreciable reduction of the lesion's size. He is alive with persistent severe visual disturbance 14 months after the diagnosis. We discuss the etiopathogenetic, diagnostic, and therapeutic issues related to this entity, and review the literature.
authors.affiliation: Dipartimento di Patologia Umana e Oncologia, Università degli Studi di Firenze, Firenze, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Buccoliero
authors.forename: Adele
authors.initials: A
authors.lastname: Caldarella
authors.forename: Marco
authors.initials: M
authors.lastname: Santucci
authors.forename: Franco
authors.initials: F
authors.lastname: Ammannati
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mennonna
authors.forename: Antonio
authors.initials: A
authors.lastname: Taddei
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Taddei
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology*; D006104:Granuloma, Plasma Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008297:Male; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D017211:Treatment Failure; D014786:Vision Disorders / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy