title: In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin.
abstract: OBJECTIVE
  To investigate whether poly (oleic/linoleic acid dimer: sebacic acid)-getamicin [Poly(OAD/LOAD:SA)-gentamicin] delivery system was useful to treat chronic osteomyelitis.
  
  
  METHODS
  Drug delivery system consisted of gentamicin sufate dispersed in a copolymer containing oleic/linoleic acid dimer (OAD/LOAD) and sebacic acid (SA) in a 1:1 weight ratio. The gentamicin release from [Poly(OAD/LOAD:SA)-gentamicin] was tested in water, 0.9 % saline, and phosphate buffer 0.1 mol/L.
  
  
  RESULTS
  The gentamicin concentration peak was found on d 2, then slowly decreased, considerable amount of gentamicin was still released on d 50. From d 2 to d 50, the gentamicin concentration in the releasing fluids was from 59 to 42128-fold and 1.8 to 1314-fold of the MIC for Staphylococcus aureus and Escherichia coli, respectively. Staphylococcus aureus and Escherichia coli were strongly inhibited by the releasing fluids for 50 d. The gentamicin release and anti-bacterial activity in the three media were similar, only in 0.1 mol/L phosphate buffer, from d 2 to d 14 it was lower.
  
  
  CONCLUSIONS
  Poly(OAD/LOAD:SA)-gentamicin was useful to treat chronic osteomyelitis.
authors.affiliation: Department of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiufenyang@163.net
authors.forename: Xiu-Fen
authors.initials: XF
authors.lastname: Yang
authors.forename: Fan-Dian
authors.initials: FD
authors.lastname: Zeng
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Zhou
authors.forename: Kai-Xun
authors.initials: KX
authors.lastname: Huang
authors.forename: Hui-Bi
authors.initials: HB
authors.lastname: Xu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D003652:Decanoic Acids / Q000737:chemistry; D003692:Delayed-Action Preparations; D003998:Dicarboxylic Acids / Q000737:chemistry; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects*; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D019787:Linoleic Acid / Q000737:chemistry; D019301:Oleic Acid / Q000737:chemistry; D011108:Polymers; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D003692:Delayed-Action Preparations; D003998:Dicarboxylic Acids; D005839:Gentamicins; D011108:Polymers; D019301:Oleic Acid; C011107:sebacic acid; D019787:Linoleic Acid