[The advance of research on pathogenesis of acquired pure red cell aplastic anemia caused by cellular immune abnormalities].
Pure red cell aplastic anemia (PRCA) is a group of heterogeneous disorders characterized by erythropoiesis failure or disorder of bone marrow function. PRCA can be classified as congenital and acquired types. The recent researches have shown that cellular immune abnormalities are main reasons to cause PRCA. This review will focus on the focus points: T lymphocytes abnormalities, change of T-cell subset phenotypes, abnormality of cellular clonality, and effects of related cytokines in PRCA.
Dai
Yang
Y
Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, China. tingliu@mail.sc.cninfo.net
D006801:Humans; D007154:Immune System Diseases / Q000097:blood* / Q000150:complications; D007111:Immunity, Cellular / Q000276:immunology; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000276:immunology*; D012106:Research / Q000639:trends; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology