Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program.
A combined analysis of genome scans was performed for adult height in the NHLBI Family Blood Pressure Program. Height data were available on 6752 individuals. Linkage analysis was performed first separately for each of the eight ethnic groups in the four networks using the variance component method. To increase the power to detect the common genetic components affecting height for all the individuals, a linkage analysis was performed subsequently for the combined data set by pooling the average allele-sharing IBD () for all groups. By combining the data, we replicated evidence for a QTL influencing adult height on chromosome 7 (7q31) (LOD=2.46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously.
Wu
Xiaodong
X
Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA. xwu@apache.medctr.luhs.org
Cooper
Richard S
RS
Boerwinkle
Eric
E
Turner
Stephen T
ST
Hunt
Steve
S
Myers
Richard
R
Olshen
Richard A
RA
Curb
David
D
Zhu
Xiaofeng
X
Kan
Donghui
D
Luke
Amy
A
D000328:Adult; D001827:Body Height / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D009316:National Institutes of Health (U.S.); D040641:Quantitative Trait Loci / Q000235:genetics*; D014481:United States