title: Lipid chemistry--a personal view of some developments in the last 60 years.
abstract: This review tracks some of the changes in fatty acid chemistry that have occurred during the past 60 years. Once disparaged, this topic is now recognised as important in biochemistry and nutrition. Among the significant areas that are addressed are fatty acid oxidation and hydrogenation, fatty acid synthesis, and selected reactions of the carboxyl group and of unsaturated centres. Underlying many of the developments that have occurred have been important advances in lipid analysis and a clearer understanding of reaction mechanism and stereochemistry. Developments in the future will include greater use of enzymes in technological processes and will result from environmental pressures to conduct reactions under milder conditions, use less solvent, and produce less waste.
authors.affiliation: University of St. Andrews, St. Andrews, Scotland, UK. fdg1@st-andrews.ac.uk <fdg1@st-andrews.ac.uk>
authors.forename: Frank D
authors.initials: FD
authors.lastname: Gunstone
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry; D005227:Fatty Acids / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000737:chemistry; D006865:Hydrogenation; D008055:Lipids / Q000737:chemistry*; D008968:Molecular Conformation; D010084:Oxidation-Reduction
chemical_list: D004852:Epoxy Compounds; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008055:Lipids