[Ultrastructural changes in cells of the antral gastric mucosa in patients with duodenal ulcers treated with melatonin].
OBJECTIVE
To study ultrastructural condition of the cels in antral gastric mucosa in patients with duodenal ulcer on melatonin treatment.


METHODS
Electron microscopy was made of biopsy specimens of antral stomach mucosa obtained from 14 patients with duodenal ulcer (DU) in exacerbation and in clinicoendoscopic remission after therapy with proton pump blockers (group 1) and after this therapy combined mth melatonin (group 2).


RESULTS
In patients of group 2 there was an increased number of differentiated cover and principal cells, moderately differentiated parietal cells predominated.


CONCLUSIONS
Melatonin is one of the drugs potentiating trophic processes in gastric mucosa.
Rapoport
S I
SI
Raĭkhlin
N T
NT
Malinovskaia
N K
NK
Lakshin
A A
AA
D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D008854:Microscopy, Electron; D011706:Pyloric Antrum / Q000473:pathology / Q000648:ultrastructure*
D008550:Melatonin