[Griscelli syndrome: a case report].
BACKGROUND
Griscelli syndrome is a rare disorder with poor prognosis. It is characterized by silver-grey hair or strands of silver-grey hair in childhood, and variable cellular immunodeficiency. The course of the untreated disease is fatal. Recurrent episodes of fever and lymphohistocytic infiltration of organs lead to hepatosplenomegaly, lymphadenopathy, pancytopenia, and progressive neurological impairment. Prognosis on morbidity and lethality depends on an early diagnosis.


METHODS
The girl we report on suffers from Griscelli syndrome. She developed normally and only her grey strands of hair, grey eyebrows, and eyelids were conspicuous. With the age of 4 years, she presented with a first episode of illness.


RESULTS
Cytostatic treatment seemed to ameliorate the course of the disease although further accelerated phases could not be prevented. The only therapeutic option is a bone marrow transplantation, which we conferred upon our patient.


CONCLUSIONS
The finding of grey hairs in childhood should alert clinicians to consider Griscelli syndrome since an early diagnosis is life and health saving.
Habermehl
P
P
Kinderklinik, Johannes-Gutenberg-Universität Mainz.
Althoff
S
S
Knuf
M
M
Höpner
J-H
JH
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002609:Chediak-Higashi Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002675:Child, Preschool; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D003937:Diagnosis, Differential; D018450:Disease Progression; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics* / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage; D009460:Neurologic Examination; D016116:Piebaldism / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D005047:Etoposide; D011241:Prednisone; D008727:Methotrexate