title: Systemic mycoses in the immunocompromised host: an update in antifungal therapy.
abstract: Despite significant advances in the management of immunosuppressed patients, invasive fungal infections remain an important life-threatening complication. In the last decade several new antifungal agents, including compounds in pre-existing classes (new generation of triazoles, polyenes in lipid formulations) and novel classes of antifungals with a unique mechanism of action (echinocandins), have been introduced in clinical practice. Ongoing and future studies will determine their exact role in the management of different mycoses. The acceleration of antifungal drug discovery offers promise for the management of these difficult to treat opportunistic infections.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA. dkontoyi@mdanderson.org
authors.forename: D P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: E
authors.initials: E
authors.lastname: Mantadakis
authors.forename: G
authors.initials: G
authors.lastname: Samonis
mesh_terms: D000666:Amphotericin B / Q000737:chemistry / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000737:chemistry / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D003840:Deoxycholic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D004338:Drug Combinations; D054714:Echinocandins; D005656:Fungal Proteins; D006801:Humans; D016867:Immunocompromised Host; D009181:Mycoses / Q000188:drug therapy* / Q000276:immunology; D010455:Peptides; D010456:Peptides, Cyclic; D010713:Phosphatidylcholines / Q000737:chemistry / Q000627:therapeutic use; D010715:Phosphatidylglycerols / Q000737:chemistry / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D005656:Fungal Proteins; D010455:Peptides; D010456:Peptides, Cyclic; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D014230:Triazoles; C068538:liposomal amphotericin B; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; C007572:echinocandin B