title: Effect of intravenous mannitol upon the resistive index in complete unilateral renal obstruction in dogs.
abstract: Some studies have shown that relative to baseline, the renal resistive index (RI) remains unchanged in nonobstructed kidneys and increases in obstructed kidneys after administration of furosemide. To our knowledge, the effect of mannitol administration on the renal RI of dogs has not been reported. We evaluated the renal RI in 16 kidneys in 8 young adult dogs after administration of mannitol. The mean RI decreased significantly from baseline (P < .01). Additionally, left complete ureteral obstruction wasinduced in 5 dogs. Evaluation by Doppler ultrasonography was performed for 5 days. On the 5th day, Doppler examination was repeated at 30 and 60 minutes after administration of mannitol to obstructed dogs. After induction of left ureteral obstruction, the RI of the left kidney increased significantly over 5 consecutive days. Administration of mannitol decreased the RI in the nonobstructed contralateral kidneys, and thus the RI difference between obstructed and nonobstructed kidneys was increased above normal (P < .001). In conclusion, administration of mannitol may be useful as another diuretic agent to identify unilateral ureteral obstruction on Doppler sonographic examination.
authors.affiliation: College of Veterinary Medicine, Seoul National University, Seoul, Korea.
authors.forename: Hojung
authors.initials: H
authors.lastname: Choi
authors.forename: Sungjun
authors.initials: S
authors.lastname: Won
authors.forename: Woojo
authors.initials: W
authors.lastname: Chung
authors.forename: Kichang
authors.initials: K
authors.lastname: Lee
authors.forename: Dongwoo
authors.initials: D
authors.lastname: Chang
authors.forename: Heechun
authors.initials: H
authors.lastname: Lee
authors.forename: Kidong
authors.initials: K
authors.lastname: Eom
authors.forename: Youngwon
authors.initials: Y
authors.lastname: Lee
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
mesh_terms: D000818:Animals; D004234:Diuretics, Osmotic / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D014463:Ultrasonography; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology* / Q000662:veterinary*
chemical_list: D004234:Diuretics, Osmotic; D008353:Mannitol