Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes.
The derivatization of racemic 5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, developed as an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate was performed in chloroform. The reaction led to two pairs of diastereomers, which were separated by RP-HPLC. A kinetic study of the derivatization reaction was achieved in order to establish conditions suitable for experimental drug monitoring.
Matoga
Myriam
M
EA 2962-Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
Forfar
Isabelle
I
Chaimbault
Corinne
C
Guillon
Jean
J
Péhourcq
Fabienne
F
Bosc
Jean-Jacques
JJ
Rettori
Marie-Claire
MC
Jarry
Christian
C
D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016903:Drug Monitoring / Q000379:methods*; D017953:Isocyanates / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
D017953:Isocyanates; D008024:Ligands; D010080:Oxazoles; C060557:alpha-methylbenzyl isocyanate