Application of pharmacophore models for the design and synthesis of new anticonvulsant drugs.
The chemical diversity and various mechanisms of action of anticonvulsants make it difficult to identify a common pharmacophore. The present review outlines different pharmacophore models for anticonvulsant activity with emphasis on the development of new drugs. Some of them represent models for structurally different classes of compounds with similar mechanisms of action. Others represent pharmacophore models for similar chemical classes of compounds for which the mechanism of anticonvulsant action is not clear. A pharmacophore model for sodium channel blocking compounds, anticonvulsants with the phthalimide pharmacophore, a model for anticonvulsant semicarbazones, and a model for GABA uptake inhibitors are presented.
Malawska
Barbara
B
Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. mfmalaws@cyf-kr.edu.pl
Scatturin
Angelo
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D018756:GABA Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D010797:Phthalimides / Q000138:chemical synthesis / Q000494:pharmacology; D012664:Semicarbazones / Q000138:chemical synthesis / Q000494:pharmacology; D026941:Sodium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D018756:GABA Antagonists; D010797:Phthalimides; D012664:Semicarbazones; D026941:Sodium Channel Blockers