title: Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.
abstract: Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionation procedure. The hydrolysate showed inhibition of adjuvant induced arthritis in rats. After further fractionation, the ethyl acetate fraction exhibited antiarthritic activity, which resulted in the isolation of alpha-hederin, alpha-hederin methyl ester, and kalopanaxsaponin I. All compounds showed inhibition of vascular permeability in mice, but only alpha-hederin methyl ester showed anticarrageenan activity in rats and antiarthritic activity in rats and mice.
authors.affiliation: Natural Products Research Institute, Seoul National University, Korea.
authors.forename: Da Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Jin Ee
authors.initials: JE
authors.lastname: Hyun
authors.forename: Choon Sik
authors.initials: CS
authors.lastname: Jeong
authors.forename: Yeong Shik
authors.initials: YS
authors.lastname: Kim
authors.forename: Eun Bang
authors.initials: EB
authors.lastname: Lee
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy; D000440:Butanols / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004952:Esters; D006868:Hydrolysis; D036882:Kalopanax; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000440:Butanols; D004952:Esters; D010936:Plant Extracts; D012503:Saponins; C010177:beta-hederin; D009828:Oleanolic Acid