title: Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity.
abstract: The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity.
authors.affiliation: Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
authors.forename: Veluri
authors.initials: V
authors.lastname: Ravikanth
authors.forename: Vanimireddy
authors.initials: V
authors.lastname: Lakshmi Niranjan Reddy
authors.forename: Adelli
authors.initials: A
authors.lastname: Vijender Reddy
authors.forename: Kodela
authors.initials: K
authors.lastname: Ravinder
authors.forename: Tadikamalla
authors.initials: T
authors.lastname: Prabhakar Rao
authors.forename: Tejomoorty
authors.initials: T
authors.lastname: Siva Ram
authors.forename: Kondapi
authors.initials: K
authors.lastname: Anand Kumar
authors.forename: Diwan
authors.initials: D
authors.lastname: Prakesh Vamanarao
authors.forename: Yenamandra
authors.initials: Y
authors.lastname: Venkateswarlu
mesh_terms: D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D028481:Euphorbia; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D003603:Cytotoxins; D004224:Diterpenes; D010936:Plant Extracts