Preparation of highly substituted 4-aminopyridones via the reaction of 2-methylene dihydrobenzimidazole with vinyl isocyanates.
[reaction: see text] The rapid construction of highly substituted 4-aminopyridones was achieved employing an efficient cyclization between various vinyl isocyanates and 2-methylene dihydrobenzimidazole.
Rigby
James H
JH
Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA. jhr@chem.wayne.edu
Lee
Chee-Seng
CS