title: [Usefulness of soluble ICAM-1 measurements for the evaluation of the disease activity and efficiency of therapy in patients with infiltrative Graves' ophthalmopathy].
abstract: The authors studied serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) in patients with progressive Graves' ophthalmopathy (GO), stable GO, hyperthyroid Graves' disease (GD) without GO and in healthy controls. The highest serum concentrations of sICAM-1 were observed in patients with progressive GO. In patients with stable GO and GD mean serum levels of sICAM-1 were elevated to a lesser degree. Mean serum concentrations of sICAM-1 decreased significantly during treatment of patients with the progressive GO parallel to the improvement of the eye changes. In patients with hyperthyroid GD serum levels of sICAM-1 decreased significantly after they had become euthyroid. Mean sICAM-1 level in the euthyroid GD was markedly decreased in comparison to the group of patients with progressive GO and slightly elevated when compared to stable GO. In conclusion, serum levels of sICAM-1 seems to be a good parameter of disease activity in progressive infiltrative GO. The decrease in sICAM-1 concentrations in patients with the progressive GO closely corresponds to the improvement of the clinical picture of the progressive GO.
authors.affiliation: Klinika Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii Pomorskiej AM w Szczecinie.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kulig
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pilarska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kulig
authors.forename: Barbara
authors.initials: B
authors.lastname: Krzyzanowska-Swiniarska
authors.forename: Maciej
authors.initials: M
authors.lastname: Robaczyk
authors.forename: Artur
authors.initials: A
authors.lastname: Baraniak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D000893:Anti-Inflammatory Agents; D018799:Intercellular Adhesion Molecule-1; D008775:Methylprednisolone