title: Preparation and cancer cell invasion inhibitory effects of C16-alkynic fatty acids.
abstract: Five C(16)-alkynic fatty acids (2-6) were prepared and examined their inhibitory effects on cancer cell invasion. It has been found that hexadeca-6,8,10-triynoic acid (5) and hexadeca-8,10,12-triynoic acid (6) exhibit similar potent inhibitory activities with that of octadeca-8,10,12-triynoic acid (1) which was isolated from Scurrula atropurpurea (Loranthaceae).
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzo, 1 Gakuen-cho, Hiroshima, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Hendig
authors.initials: H
authors.lastname: Winarno
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Mukai
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D028183:Loranthaceae; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D005227:Fatty Acids; D006131:Growth Inhibitors; D010936:Plant Extracts