title: Proteomic applications for the early detection of cancer.
abstract: The ability of physicians to effectively treat and cure cancer is directly dependent on their ability to detect cancers at their earliest stages. Proteomic analyses of early-stage cancers have provided new insights into the changes that occur in the early phases of tumorigenesis and represent a new resource of candidate biomarkers for early-stage disease. Studies that profile proteomic patterns in body fluids also present new opportunities for the development of novel, highly sensitive diagnostic tools for the early detection of cancer.
authors.affiliation: NCI/FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
authors.forename: Julia D
authors.initials: JD
authors.lastname: Wulfkuhle
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta
authors.forename: Emanuel F
authors.initials: EF
authors.lastname: Petricoin
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood* / Q000235:genetics; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020543:Proteome