title: Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction.
abstract: A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87-90% e.e.
authors.affiliation: Department of Chemistry, UMIST, Sackville Street, Manchester, UK M60 1QD. john.gardiner@umist.ac.uk
authors.forename: John M
authors.initials: JM
authors.lastname: Gardiner
authors.forename: Philip D
authors.initials: PD
authors.lastname: Crewe
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Smith
authors.forename: Kenneth T
authors.initials: KT
authors.lastname: Veal