title: [Application of viable cryopreserved alloderm transplants in the treatment of wound defects of soft tissues].
abstract: An original method is proposed for treatment of long-standing intractable wounds and trophic ulcers using viable cryopreserved allodermotransplants and a distant air-plasma treatment. The main source of the allodermotransplants is the cadaverous skin. It was shown that the cadaverous skin taken during 17 hours after the donor's death was viable. The maximum period for storage of the viable skin when the worked out preservative is used at the temperature regimen -18 degrees C is 10 days, and at -70 degrees C it can be as long as 45 days. The analysis performed included 101 patients with long-standing intractable wounds and trophic ulcers. In 51 of them the new worked out method was used. An analysis of clinical and histomorphological data has proved that the application of the viable cryopreserved allodermotransplants and distant air-plasma treatment favor the better course of reparative processes. By the end of the forth week the wounds were completely closed in 19.7% of patients, the wound areas were considerably less (more than by 50% of the initial size) in 43.1%, less reduction of the wound area (less than 50% of the initial size) in 27.4%, in 9.8% there was no effect. No negative results were noted. It should be noted that closure of the tissue defect can be achieved by stimulation of the physiological regeneration of the patient's tissues. This method of regeneration of the skin is effective in trophic ulcers, long-standing intractable wounds and is also recommended in case of deficit of donor resources or when the severe state of the patient does not allow active surgical treatment.
authors.forename: V I
authors.initials: VI
authors.lastname: Khrupkin
authors.forename: A N
authors.initials: AN
authors.lastname: Ivashkin
authors.forename: L V
authors.initials: LV
authors.lastname: Pisarenko
authors.forename: A V
authors.initials: AV
authors.lastname: Nizovoĭ
authors.forename: E M
authors.initials: EM
authors.lastname: Fominykh
authors.forename: I V
authors.initials: IV
authors.lastname: Kiselev
authors.forename: A N
authors.initials: AN
authors.lastname: Kuzin
authors.forename: D N
authors.initials: DN
authors.lastname: Fedorov
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
authors.forename: V V
authors.initials: VV
authors.lastname: Terskikh
mesh_terms: D002470:Cell Survival / Q000502:physiology; D003094:Collagen; D015925:Cryopreservation; D006801:Humans; D009569:Nitric Oxide / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014665:Vasodilator Agents / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: C440568:Alloderm; D014665:Vasodilator Agents; D009569:Nitric Oxide; D003094:Collagen