Is there a relationship between HLA type and prognostic factors in breast cancer?
No convincing association exists between HLA type and breast cancer development but certain HLA types have been suggested to be associated with poor risk disease. Here, the HLA type (class I and II) for 141 breast cancer patients was compared to a control population of 100 individuals and to the prognostic indicators for the patients. No association was found between HLA type and breast cancer development. Consideration of individual HLA/prognostic factor relationships previously reported confirmed that HLA-B7 was over-represented in premenopausal oestrogen-receptor (ER)-positive, grade 3 tumours (p = 0.04) and that HLA-A1 correlated positively with Nottingham Prognostic Index (p < 0.05) and with ER-negative disease (p < 0.05). These findings suggest that some previously identified associations between HLA type I and particular prognostic factors may be real, if weak but appear to conflict with the only other sizeable study investigating HLA type II in breast cancer (which negatively correlated HLA-DR 11 with early onset disease).
Gourley
C
C
Department of Clinical Oncology, University of Edinburgh Cancer Research Center, Western General Hospital, Crewe Road, Edinburgh EH4 2XR, Scotland. charles.gourley@cancer.org.uk
Thornton
C
C
Massie
C
C
Prescott
R J
RJ
Turner
M
M
Leonard
R C F
RC
Kilpatrick
D C
DC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D015234:HLA-A Antigens / Q000097:blood* / Q000145:classification; D015235:HLA-B Antigens / Q000097:blood* / Q000145:classification; D006684:HLA-DR Antigens / Q000097:blood* / Q000145:classification; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000096:biosynthesis
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D011960:Receptors, Estrogen