[Practical use of taxol-based chemotherapy for poor compliance gynecologic cancers in Japanese woman].
Today, the first line of chemotherapy for ovarian cancer is Taxol-carboplatin (T-J), but there are some problems including severe bone marrow depression and severe neuropathy, so-called poor compliance cases. By changing the method of administering Taxol, the key drug in chemotherapy for ovarian cancer, it is possible to make compliance more better, continue therapies and look after patients' PS and QOL. We have considered weekly Taxol based chemotherapy for early stage recurrence cases and poor compliance cases; For example, weekly Taxol in combination with carboplatin (monthly) for poor compliance cases, severe bone marrow depression and the like, and Taxol by drip infusion for 24 hours in cases of peripheral nerve disorder (severe neuropathy). Especially, weekly Taxol combination with carboplatin (monthly), with takes advantage of the repeated administration of Taxol and one time administration of carboplatin, is a highly beneficial therapy for ovarian cancer. With this protocol we can reduce side effects and continue long-term administration on an outpatient basis.
Mitsui
Mari
M
Dept. of Obstetrics and Gynecology, Yokosuka Municipal Hospital.
Takashi
Kanaeda
K
Imai
Kazuo
K
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003187:Compliance; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage*; D011788:Quality of Life; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
D016190:Carboplatin; D017239:Paclitaxel