title: Clinical outcome, inflammatory response and tissue trauma in total laparoscopic hysterectomy: comparison to laparoscopically-assisted vaginal hysterectomy.
abstract: OBJECTIVE
  Our aim was quantify and compare the clinical outcome and surgical inflammatory response and tissue trauma between the total laparoscopic hysterectomy (TLH) and laparoscopically-assisted vaginal hysterectomy (LAVH).
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  Departments of Gynaecology, Obstetrics and Biochemistry, Hospital Kladno, Department of Biochemistry, Faculty Hospital Motol-Prague.
  
  
  METHODS
  Fifty-eight patients scheduled for laparoscopic hysterectomy were selected according patients or doctor preference to undergo either TLH or LAVH operative technique. Blood samples for assay of markers of tissue trauma (C-reactive protein, interleukin-6, creatine kinase, cortisol, cystatin C, serotonin and white blood cells count) were taken preoperatively, on the first and third postoperative day. One patient with intraoperative complication (ureteral injury) was excluded from tissue analysis.
  
  
  RESULTS
  No differences were present in the demographic characteristics and clinical outcomes (blood loss, complications and hospital stay) in fifty seven laparoscopic hysterectomies. The statistically significant difference was found only in duration of surgery (70 min in TLH group vs. 90 min in LAVH group, P < 0.05). This difference can be related to difference in uterine specimen weight (185 g in TLH group vs. 289 g in LAVH group, P < 0.02). Both the LAVH (n = 37) and TLH (n = 20) resulted in statistically significant changes in the inflammatory and systemic immune response in comparison with preoperative value. No significant differences were observed in the studied inflammatory and tissue markers between the studied operative techniques of laparoscopic hysterectomy.
  
  
  CONCLUSIONS
  The total laparoscopic hysterectomy and laparoscopically-assisted vaginal hysterectomy were equally traumatic in terms of surgical inflammatory response and tissue trauma.
authors.affiliation: Department of Gynaecology and Obstetrics, Endoscopic Training Centre, Hospital Kladno. holubz@seznam.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Holub
authors.forename: A
authors.initials: A
authors.lastname: Jabor
authors.forename: L
authors.initials: L
authors.lastname: Sprongl
authors.forename: D
authors.initials: D
authors.lastname: Fischlová
authors.forename: S
authors.initials: S
authors.lastname: Urbánek
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy; D007958:Leukocyte Count; D008875:Middle Aged; D011446:Prospective Studies; D013312:Stress, Physiological / Q000175:diagnosis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D002097:C-Reactive Protein; D003402:Creatine Kinase