title: [A comparative study on safety and immunogenicity of an inactivated hepatitis A vaccine in HBsAg carriers and healthy children].
abstract: OBJECTIVE
  To evaluate safety and immunogenicity of inactivated hepatitis A vaccine in HBsAg carriers and healthy children.
  
  
  METHODS
  One hundred and twenty-one healthy children and ten HBsAg carriers, aged 1-10 years HAV susceptible were enrolled in the study. The inactivated hepatitis A vaccine was produced by Tangshan Biogenetic Company. The dosage of the vaccine was 1000 U/Dosage and 500 U/Dosage. The vaccination schedule was six month apart for two injections. The serum anti-HAV level was detected with EIA at one month after first injection and at one and six month after the booster injection, respectively.
  
  
  RESULTS
  The anti-HAV appeared in all the children. One month after the booster injection, the serum anti-HAV level in children vaccinated 500 U/Dosage was 4684.9 mIU and 4535.6 mIU, respectively and in the children vaccinated 1000 U/Dosage, 5399.8 mIU and 7347.1 mIU, respectively. The anti-HAV level was not statistically different between the two groups of children. There was no adverse reaction after the vaccination. The anti-HAV level was still high one year after first injection.
  
  
  CONCLUSIONS
  The data indicated that the safety and immunogenicity of the domestic inactivated hepatitis A vaccine were excellent in both groups of children.
authors.affiliation: Pingshan County Health and anti-Epidemic Station, Hebei Province 050400, China.
authors.forename: Jiangting
authors.initials: J
authors.lastname: Chen
authors.forename: Yinhai
authors.initials: Y
authors.lastname: Ren
authors.forename: Wenting
authors.initials: W
authors.lastname: Wu
authors.forename: Shoudong
authors.initials: S
authors.lastname: Ma
authors.forename: Shengping
authors.initials: S
authors.lastname: Li
authors.forename: Jianhong
authors.initials: J
authors.lastname: Wang
authors.forename: Wenxue
authors.initials: W
authors.lastname: Kang
authors.forename: Lianjun
authors.initials: L
authors.lastname: Han
authors.forename: Shuanjing
authors.initials: S
authors.lastname: Gao
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chongbai
authors.initials: C
authors.lastname: Liu
mesh_terms: D002648:Child; D002675:Child, Preschool; D035922:Hepatitis A Antibodies / Q000097:blood; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007114:Immunization; D007223:Infant; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006514:Hepatitis B Surface Antigens; D015164:Vaccines, Inactivated