title: Differentiating adult hippocampal stem cells into neural crest derivatives.
abstract: To investigate the degree of plasticity of hippocampal neural stem cells from adult mice (mHNSC), we have analyzed their differentiation in co-culture with quail neural crest cells. In mixed culture, mHNSC give rise to several non-neuronal neural crest derivatives, including melanocytes, chondrocytes and smooth muscle cells. The data suggest that neural crest cell-derived short-range cues that are recognized across species can instruct adult mHNSC to differentiate into neural crest phenotypes.
authors.affiliation: Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Alexanian
authors.forename: M
authors.initials: M
authors.lastname: Sieber-Blum
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002478:Cells, Cultured / Q000166:cytology* / Q000378:metabolism; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D018920:Coculture Techniques / Q000379:methods* / Q000639:trends; D003463:Cues; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D051379:Mice; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology* / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D011784:Quail; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism