title: Evaluation of lenticonus in Alport's syndrome: quantitative Scheimpflug analysis.
abstract: Anterior lenticonus is an ocular abnormality that can occur in Alport's syndrome. In this study, Scheimpflug slit imaging analyses were employed for quantitative and objective evaluation of lens changes associated with Alport's syndrome. It was determined that while the apices of the lenticular protrusions are central in the vertical plane, they are nasally displaced in the horizontal meridian. The eccentricity and dimensions of the diameters and thicknesses of the conical aberration are highly correlated in both eyes. Lens thickness and anterior chamber depth do not differ between eyes. Densitometrically similar differences are apparent in the cortex and nuclear regions although evidence of overt opacification may or may not be present. The data strongly suggest that the physical parameters of the lenticonus are consistent with the constraints imposed by the pupil. Changes observed in the cornea and the vitreous may be associated with the syndrome.
authors.affiliation: Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University, New York, NY, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Marc
authors.initials: M
authors.lastname: Hirsch
authors.forename: Anna K
authors.initials: AK
authors.lastname: Junk
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Casper
authors.forename: Richard
authors.initials: R
authors.lastname: Braunstein
authors.forename: Janice
authors.initials: J
authors.lastname: David
authors.forename: Basil V
authors.initials: BV
authors.lastname: Worgul
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D003941:Diagnostic Techniques, Ophthalmological; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007903:Lens Capsule, Crystalline / Q000002:abnormalities*; D007904:Lens Cortex, Crystalline / Q000002:abnormalities*; D008297:Male; D009394:Nephritis, Hereditary / Q000150:complications / Q000175:diagnosis*; D010781:Photography / Q000295:instrumentation / Q000379:methods; D014792:Visual Acuity