title: Clinical response of captive common wombats (Vombatus ursinus) infected with Sarcoptes scabiei var. wombati.
abstract: Seven common wombats (Vombatus ursinus) were exposed and two of these were re-exposed to Sarcoptes scabiei var. wombati (Acari: Sarcoptidae). For wombats exposed for the first time, five exposed to 5,000 mites on their shoulder developed moderate to severe parakeratotic mange after 11 wk compared with two given 1,000 mites that developed mild clinical signs of mange after 11 wk. For re-exposed wombats, one of two given 5,000 mites developed mild parakeratotic mange and the other developed severe parakeratotic mange. Initial signs of mange were erythema followed by parakeratosis, alopecia, excoriation and fissuring of parakeratotic crust and skin. Erythema usually became apparent within 14 days after exposure (DAE) or within 24 hrs of re-exposure. Parakeratosis was visible 14-21 DAE and alopecia first occurred 35-77 DAE. Clinical signs increased in severity over time and lesions spread slowly from the site of exposure. Mangy wombats scratched excessively, lost weight, and exhibited a significant neutrophilia compared with control wombats. Treatment of mange with three injections of ivermectin, 300 micrograms/kg, 10 days apart led to complete resolution of clinical signs. However mites were not entirely eliminated until wombats received a second regime of treatment.
authors.affiliation: University of Melbourne, School of Veterinary Science, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia. lskerratt@usgs.gov
authors.forename: Lee F
authors.initials: LF
authors.lastname: Skerratt
mesh_terms: D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D004890:Erythema / Q000209:etiology / Q000662:veterinary; D005260:Female; D007306:Insecticides / Q000494:pharmacology / Q000627:therapeutic use*; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008394:Marsupialia / Q000469:parasitology*; D010865:Pilot Projects; D011897:Random Allocation; D012520:Sarcoptes scabiei / Q000254:growth & development*; D012532:Scabies / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D012867:Skin / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D007559:Ivermectin