title: Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis.
abstract: We examined the therapeutic effect of a 1% cream preparation of NND-502, a novel topical antifungal agent, in a guinea pig tinea pedis model produced by infecting the plantar skin of guinea pigs with Trichophyton mentagrophytes. Animals developing tinea pedis were divided into two groups: an untreated control group and a treated group. In the latter group, after confirming infection had been established, the infected animals were topically treated with the NND-502 cream once daily for one week. The animals were reared in a clean environment free from exposure to exogenous dermatophytes. At one week (5 weeks post-infection), 6 weeks (10 weeks post-infection) and 16 weeks (20 weeks post-infection) after completion of the treatment, plantar skin samples were taken from a certain number of both groups of animals. The results demonstrated that all of the animals in the untreated control group and none of those in the treated group were culture-positive in this animal model of tinea pedis. The topical treatment with NND-502 achieved a mycological cure. Thus NND-502 can be considered a promising candidate as a new anti-dermatophytic agent for topical use.
authors.affiliation: Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192-0395, Japan. kuchida@main.teikyo-u.ac.jp
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Uchida
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003470:Culture Media; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000627:therapeutic use*; D012867:Skin / Q000382:microbiology; D014008:Tinea Pedis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; C112528:luliconazole