Perftoran as a means modulating the functional activity of liver macrophages.
Experiments on mice showed that perfluorocarbon emulsion Perftoran modulated phagocytic activity of liver macrophages (evaluated by LD50 for Salmonella typhi endotoxin and the rate of elimination of Chinese ink particles from the bloodflow). Phagocytic activity was suppressed for 3 days after injection of 10 mg/kg emulsion, but then increased above the control. Perftoran had a favorable impact on the course of experimental hepatitis in a model experiment based on hyperactivity of Kupffer cells. Perftoran virtually prevented the development of severe hepatitis after prophylactic injection and notably attenuated hepatocyte cytolysis when used as therapeutic mean.
Kovelenov
A Yu
AY
Department of Infectious Diseases, S. M. Kirov Military Medical Academy, St. Petersburg, Russia.
Mikhal'tsov
A N
AN
Malkov
A N
AN
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology* / Q000627:therapeutic use; D002244:Carbon; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000517:prevention & control; D004396:Coloring Agents / Q000493:pharmacokinetics; D005466:Fluorocarbons / Q000494:pharmacology* / Q000627:therapeutic use; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism*; D007928:Lethal Dose 50; D008099:Liver / Q000166:cytology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects
D001802:Blood Substitutes; D004396:Coloring Agents; D005466:Fluorocarbons; C028433:chinese ink; D002244:Carbon; C063334:perftoran; D000410:Alanine Transaminase