Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography.
Positron emission tomography (PET) provides the oncologist with information on tumour diagnosis, and treatment response monitoring. Mathematical modelling of tissue data, and online plasma radioactive metabolite profiling, enables important tissue kinetic parameters relating to the uptake, distribution and washout as well as arterial input function to be derived. The resultant kinetic data allow for not only diagnosis but also the assessment of therapeutic response endpoints. These endpoints can be used to measure specific therapeutic effects. This novel application of PET can provide information that is often difficult to measure in the intact animal or patient. The pharmacokinetics of radiolabelled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA), temozolomide and 5-fluorouracil (5-FU) are described.
Hutchinson
O Clyde
OC
Cancer Research UK, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Collingridge
David R
DR
Barthel
Henryk
H
Price
Pat M
PM
Aboagye
Eric O
EO
D000166:Acridines / Q000493:pharmacokinetics; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D005472:Fluorouracil / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D015394:Molecular Structure; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*; D000077204:Temozolomide; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D000166:Acridines; D000970:Antineoplastic Agents; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals; D003606:Dacarbazine; C058332:N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide; D005472:Fluorouracil; D000077204:Temozolomide