Dax1 is required for testis determination.
The orphan nuclear receptor, Dax1, was originally proposed to act as an 'anti-testis' factor. We find, however, that Nr0b1 (also called Dax1 and Ahch, which encodes Dax1) is in fact required for testis differentiation.
Meeks
Joshua J
JJ
Division of Endocrinology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Weiss
Jeffrey
J
Jameson
J Larry
JL
D000818:Animals; D003433:Crosses, Genetic; D057137:DAX-1 Orphan Nuclear Receptor; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D012734:Disorders of Sex Development; D005260:Female; D024282:Genes, sry; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009115:Muridae; D018168:Receptors, Retinoic Acid / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D012097:Repressor Proteins; D012733:Sex Differentiation / Q000235:genetics* / Q000502:physiology*; D013737:Testis / Q000196:embryology*; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*
D057137:DAX-1 Orphan Nuclear Receptor; D004268:DNA-Binding Proteins; C539966:Nr0b1 protein, mouse; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins; D014157:Transcription Factors