Effect of chloroquine on liver weight of developing albino rats.
OBJECTIVE
To see the effect of chloroquine on liver weight of developing albino rats.


METHODS
Twenty four pregnant female albino rats were used and divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700 mg/kg body weight in first second and third weeks of pregnancy.


RESULTS
Chloroquine caused decrease in liver weight in offsprings specially in those which were exposed to drug during second and third week of pregnancy.


CONCLUSIONS
The use of chloroquine should be avoided during pregnancy.
Zahid
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A
Department of Anatomy, Allama Iqbal Medical College and Edward Medical College, Lahore.
Abidi
T S
TS
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D008098:Litter Size; D008099:Liver / Q000187:drug effects* / Q000196:embryology; D023421:Models, Animal; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal; D011336:Probability; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D018570:Risk Assessment
D002738:Chloroquine