title: Histopathologic score predicts recurrence free survival after radical surgery in patients with stage IA2-IB1-2 cervical carcinoma.
abstract: BACKGROUND
  The authors evaluated clinical and pathologic factors that predicted for recurrence after patients underwent radical surgery for International Federation of Gynecology and Obstetrics (FIGO) Stage IA(2)-IB(1-2) cervical carcinoma and developed a simple method of scoring those predictive factors to quantify outcome.
  
  
  METHODS
  An analysis was conducted of a prospective radical surgery cervical carcinoma data base. A Cox proportional hazards regression analysis was done for each of the individual factors to estimate individual risk ratios using all available data for each factor. Stepwise and best-model options were used to identify the best combinations as predictors and to calculate adjusted risk ratios. Based on the information obtained, each patient was assigned a categorical score to predict recurrence. The variables used for the score were dichotomized. The differences between the scores in time to recurrence were evaluated using the log-rank test to compare the time to recurrence curves that were generated with the Kaplan-Meier method.
  
  
  RESULTS
  Eight hundred seventy-one patients were included in the study, and 66 patients who developed recurrent disease after a median follow-up of 49 months. Tumor size, maximum depth of invasion, pelvic lymph node status, tumor grade, and capillary lymphatic space (CLS) were single predictors for recurrence, and the score, which was based on combinations of these factors, predicted the disease free survival. Maximum depth of invasion, pelvic lymph node status, and CLS were the best combined predictors for recurrence, and they were used to form a second, precise scoring system to predict disease free survival (P < 0.0001; log-rank test).
  
  
  CONCLUSIONS
  The scoring system based on maximal depth of invasion, CLS, and pelvic lymph node metastases identified four strata of patients with distinct recurrence free survival. The incremental presence of each factor decreased recurrence free survival after patients underwent radical surgery. Patients with the presence of all three factors had a 5-year recurrence free survival rate of 65%. These patients would be suitable for studies of postoperative adjuvant therapy to improve outcome.
authors.affiliation: Division of Gynecological Oncology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Dan A
authors.initials: DA
authors.lastname: Grisaru
authors.forename: Allan
authors.initials: A
authors.lastname: Covens
authors.forename: Edmee
authors.initials: E
authors.lastname: Franssen
authors.forename: William
authors.initials: W
authors.lastname: Chapman
authors.forename: Patricia
authors.initials: P
authors.lastname: Shaw
authors.forename: Terence
authors.initials: T
authors.lastname: Colgan
authors.forename: Joan
authors.initials: J
authors.lastname: Murphy
authors.forename: Denny
authors.initials: D
authors.lastname: DePetrillo
authors.forename: Gordon
authors.initials: G
authors.lastname: Lickrish
authors.forename: Stefane
authors.initials: S
authors.lastname: Laframboise
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*