Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect.
Whelan
Jay
J
Department of Nutrition, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996-1900, USA.
Petrik
Melissa B Hansen
MB
McEntee
Michael F
MF
Obukowicz
Mark G
MG
D011125:Adenomatous Polyposis Coli / Q000473:pathology / Q000517:prevention & control*; D025601:Adenomatous Polyposis Coli Protein / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000284:Administration, Oral; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D004032:Diet; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D017491:Genes, APC; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010743:Phospholipids / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000494:pharmacology*; D017965:gamma-Linolenic Acid / Q000494:pharmacology*
D025601:Adenomatous Polyposis Coli Protein; D010743:Phospholipids; D011453:Prostaglandins; D017962:alpha-Linolenic Acid; D016718:Arachidonic Acid; D017965:gamma-Linolenic Acid; D015118:Eicosapentaenoic Acid; D015232:Dinoprostone