Microenvironmental regulation of Notch signalling in T cell development.
T cells develop in the thymus from blood-borne progenitors derived from haematopoietic tissues. Amongst the mechanisms by which stromal cells in thymic and prethymic tissues influence lymphoid progenitors, recent attention has focussed on the importance of Notch signalling in early T cell development. Here, we review evidence that developing T cells and their progenitors receive signals through Notch receptors as a result of interactions with Notch ligands expressed by stromal cells. In particular, we focus on the role of Notch ligand-expressing stromal cells in regulating key control points during pre- and intrathymic phases of T cell development.
Harman
Benjamin C
BC
Department of Anatomy, Division of Immunity and Infection, Medical School, MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Jenkinson
Eric J
EJ
Anderson
Graham
G
D000818:Animals; D002135:Calcium-Binding Proteins; D002450:Cell Communication; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008099:Liver / Q000196:embryology / Q000276:immunology; D008565:Membrane Proteins / Q000819:agonists / Q000502:physiology*; D011506:Proteins / Q000819:agonists; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; D015398:Signal Transduction; D017154:Stromal Cells / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology*
D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; C064045:delta protein