title: Autologous blood cell transplantation in multiple myeloma: impact of CD34+ cell selection with long follow-up.
abstract: Positive CD34(+) selection to purge blood cell harvests is one way to attempt to reduce the high relapse risk after high-dose chemotherapy (HDT) supported by autologous blood cell transplantation (ABCT) in patients with multiple myeloma (MM). Until recently, however, the impact of CD34(+) selection, if any, on long-term clinical outcome in MM has remained obscure. We have analyzed engraftment kinetics, response to HDT, progression-free survival (PFS), and overall survival (OS) for 64 consecutive MM patients who have been treated with up-front HDT plus ABCT at our institution between 1993 and 1998. Nonrandomized comparisons were made between transplants with unselected (39 patients) and CD34(+)-selected (25 patients) grafts. The engraftment kinetics, need of blood product support, discharge time from hospital, and response to HDT were similar for both unselected and selected transplants. The median PFS was also similar (26 and 30 months, respectively) for the both groups. With a median follow-up time for the survivors of 67.5 months, the median OS (78 and 75 months, respectively) did not differ between transplants with unselected and selected grafts. In conclusion, this nonrandomized study suggests that positive CD34(+) selection has no beneficial impact on long-term outcome of patients with MM.
authors.affiliation: Department of Medicine, Turku University Central Hospital, FIN-20520 Turku, Finland. kari.remes@tyks.fi
authors.forename: K
authors.initials: K
authors.lastname: Remes
authors.forename: M
authors.initials: M
authors.lastname: Itälä
authors.forename: M
authors.initials: M
authors.lastname: Kauppila
authors.forename: T-T
authors.initials: TT
authors.lastname: Pelliniemi
authors.forename: A
authors.initials: A
authors.lastname: Rajamäki
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D003520:Cyclophosphamide / Q000627:therapeutic use; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007700:Kinetics; D007937:Leukapheresis / Q000379:methods; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D011500:Protein Synthesis Inhibitors / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D011500:Protein Synthesis Inhibitors; D003520:Cyclophosphamide