[Progress in somatic gene therapy].
Therapeutic gene transfer may constitute an alternative to current treatments. Despite promising results from animal studies common use of genes as drugs awaits improved vector efficiency and easier large-scale vector production. New developments in the field include high-capacity vectors with low immunogenicity, hybrid vectors, site-specific vector integration, RNA interference, and efficient non-viral gene transfer. In this article, we review the recent progress in somatic gene therapy with focus on vector development and current examples of clinical efficiency.
Mikkelsen
Jacob Giehm
JG
Stanford University School of Medicine, Departments of Pediatrics and Genetics, USA.
Jensen
Thomas Gryesten
TG
D000818:Animals; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans