title: Effects of neonatal amygdala lesions on [125I] neurotensin binding in specific brain areas of adult rat.
abstract: Neurotensin has been implicated in the pathophysiology of schizophrenia. The neonatal amygdala lesion in rat has been proposed to be a neurodevelopmental model for some aspects of schizophrenia. [125I] Neurotensin binding was assessed in adult rats using in vitro autoradiography following a lesion of the basolateral amygdala at postnatal day 7 (Pd 7) or postnatal day 21 (Pd 21). The Pd 7 and Pd 21 lesions differentially affected neurotensin receptor densities in the hippocampal complex and (less pronounced) in the dopaminergic cell regions, implying a neurodevelopmental cause. These results may be of relevance for the involvement of neurotensin in the pathogenesis of schizophrenia.
authors.affiliation: Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, Postbus 85060, 3508 AB Utrecht, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Bouwmeester
authors.forename: Jolanda
authors.initials: J
authors.lastname: Snapper
authors.forename: Eric
authors.initials: E
authors.lastname: Ronken
authors.forename: Chris G
authors.initials: CG
authors.lastname: Kruse
authors.forename: Jan M
authors.initials: JM
authors.lastname: van Ree
mesh_terms: D000679:Amygdala / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D007457:Iodine Radioisotopes; D009496:Neurotensin / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018028:Receptors, Neurotensin / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism
chemical_list: D007457:Iodine Radioisotopes; D018028:Receptors, Neurotensin; D009496:Neurotensin