[Functionalization of oligonucleotides containing internucleotide phosphoamide bonds].
A new method for functionalization of oligonucleotides by addition of aminoalkyl derivatives to the intermolecular phosphorus atom of the oligonucleotide N3'-P5' phosphoramidate bond in the presence of triphenylphosphine, 4-dimethylaminopyridine, and 2,2'-dipyridyl disulfide was suggested. The reaction proceeded with both low-molecular alkylamines (1,6-diaminohexane or N,N-dimethyl-1,3-diaminopropane) and a ligand in minor groove containing a aminoalkyl group.
Siniakov
A N
AN
Butorin
A S
AS
Novopashina
D S
DS
Halby
L
L
Riabinin
V A
VA
D000577:Amides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D000577:Amides; D009841:Oligonucleotides; D009943:Organophosphorus Compounds