title: Successful treatment of radiation-induced brain necrosis by hyperbaric oxygen therapy.
abstract: We describe a 68-year-old man who underwent hyperbaric oxygen (HBO) therapy to manage radiation necrosis of the brain, which developed after two treatments with stereotactic radiosurgery (SRS) to the same lesion. The necrosis was subsequently treated with steroids alone for 2 months; however, he progressed clinically and radiographically. Improvement again was noted with the reinstitution of HBO therapy. This case suggests that HBO therapy is an important therapeutic option in the treatment of brain radiation necrosis caused by SRS.
authors.affiliation: Department of Neurosurgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. k-kohshi@clnc.uoeh-u.ac.jp
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kohshi
authors.forename: Hajime
authors.initials: H
authors.lastname: Imada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nomoto
authors.forename: Raizoh
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Abe
authors.forename: Haruaki
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001927:Brain Diseases / Q000209:etiology / Q000628:therapy*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D006931:Hyperbaric Oxygenation; D007680:Kidney Neoplasms / Q000150:complications*; D008297:Male; D009336:Necrosis; D011832:Radiation Injuries / Q000209:etiology / Q000628:therapy*; D016634:Radiosurgery / Q000009:adverse effects*; D016896:Treatment Outcome