[Clinical significance of quantitative antibodies measurement in blood serum by interaction with muscle acetylcholine receptor domain in myasthenia patients].
Diagnostic significance of quantitative measurement of muscle acetylcholine receptor (AChR) antibodies by ELISA in patients with myasthenia was shown. Blood serum analysis of 111 patients (30 in dynamics for various treatment types) was carried out. The most essential elevation of antibodies quantity was observed in patients with generalized myasthenia type. After thymectomy it was significantly reduced. Quantitative antibodies measurement by interaction with AChR domen in ELISA is supposed to be used as additional diagnostic method of autoimmune myasthenia.
Gekht
B M
BM
Lantsova
V B
VB
Sepp
E K
EK
D000293:Adolescent; D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000097:blood* / Q000276:immunology* / Q000601:surgery; D011950:Receptors, Cholinergic / Q000097:blood / Q000276:immunology* / Q000378:metabolism*; D013934:Thymectomy; D013950:Thymus Gland / Q000601:surgery
D007074:Immunoglobulin G; D011950:Receptors, Cholinergic