title: Malaria morbidity, treatment-seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso.
abstract: OBJECTIVE
  To describe the pattern of fever-associated morbidity, treatment-seeking behaviour for fever episodes, and cause-specific mortality in young children of a malaria-holoendemic area in rural Burkina Faso.
  
  
  METHODS
  In a longitudinal community-based intervention study, 709 representative children aged 6-31 months were followed daily over 6 months (including the main malaria transmission period) through village-based field staff.
  
  
  RESULTS
  Of 1848 disease episodes, 1640 (89%) were fever episodes, and of those, 894 (55%) were attributed to malaria (fever + > or =5000 parasites/microl). Eighty-five percent of fever episodes were treated, mainly with chloroquine and paracetamol, 69% of treatments took place in households, 16% in local health centres, 13% in villages, and 1% in hospitals. Treatment-seeking in a health centre or hospital was associated with accessibility and disease severity. Cerebral malaria and malnutrition-associated diarrhoea were the most frequently diagnosed causes of death. While most children with a post-mortem diagnosis of diarrhoea had not received any treatment, children who died of malaria had often received insufficient treatment. In particular, there was a lack of an appropriate second-line treatment at formal health services after chloroquine treatment had failed to resolve symptoms.
  
  
  CONCLUSIONS
  These findings call for more effective prevention and treatment of malaria, malnutrition and diarrhoea in rural African communities, as well as for better supervision of existing malaria treatment guidelines in formal health services.
authors.affiliation: Department of Tropical Hygiene and Public Health of the Ruprecht-Karls-University, Heidelberg, Germany. olaf.mueller@urz.uni-heidelberg.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Müller
authors.forename: Corneille
authors.initials: C
authors.lastname: Traoré
authors.forename: Heiko
authors.initials: H
authors.lastname: Becher
authors.forename: Bocar
authors.initials: B
authors.lastname: Kouyaté
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D002050:Burkina Faso / Q000453:epidemiology; D002423:Cause of Death; D002675:Child, Preschool; D003967:Diarrhea / Q000401:mortality; D005260:Female; D006297:Health Services Accessibility / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D016779:Malaria, Cerebral / Q000401:mortality; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D009017:Morbidity; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic; D012423:Rural Health / Q000706:statistics & numerical data
chemical_list: D000962:Antimalarials