Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens.
The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use.
Tabart
Michel
M
Aventis Pharma, Centre de Recherche de Vitry Alfortville, 13 Quai Jules Guesde, 94403, Vitry sur Seine, France. michel.tabart@aventis.com
Picaut
Guy
G
Lavergne
Marc
M
Wentzler
Sylvie
S
Malleron
Jean-Luc
JL
Dutka-Malen
Sylvie
S
Berthaud
Nadine
N
D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D024901:Drug Resistance, Multiple, Bacterial; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
D000891:Anti-Infective Agents, Local; D009287:Naphthyridines; C006029:benzonaphthyridone