The Barbier-Grignard-type carbonyl alkylation using unactivated alkyl halides in water.
The aqueous Barbier-Grignard-type alkylation of aldehydes with unactivated alkyl iodides and bromides was developed. By using a combination of zinc and cuprous iodide, catalyzed by indium(I) chloride, we successfully added tertiary, secondary, and primary alkyl halides to various aromatic aldehydes in 0.07 M aqueous Na2C2O4. A mechanistic rationale for the success of the reaction has been proposed.
Keh
Charlene C K
CC
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Wei
Chunmei
C
Li
Chao-Jun
CJ