title: Improving the evaluation of new cancer treatments: challenges and opportunities.
abstract: There are, at present, ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. Many of the new classes of agents, however, are predicted to work in only small subpopulations of patients, target unconventional aspects of tumour development and interact with other agents in an unpredictable manner. How can clinical trials be re-designed to accommodate the new features of targeted anticancer drugs?
authors.affiliation: Vanderbilt-Ingram Cancer Center, 777 Preston Research Building, Nashville, Tennessee 37232-6307, USA. mace.rothenberg@vanderbilt.edu
authors.forename: Mace L
authors.initials: ML
authors.lastname: Rothenberg
authors.forename: David P
authors.initials: DP
authors.lastname: Carbone
authors.forename: David H
authors.initials: DH
authors.lastname: Johnson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000592:standards*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D012107:Research Design / Q000592:standards*
chemical_list: D000970:Antineoplastic Agents