title: Apolipoprotein D expression in benign and malignant prostate tissues.
abstract: BACKGROUND
  Apolipoprotein D (ApoD), a protein component of the human plasma lipid transport system, is an androgen regulated protein in both breast and prostate cancer cell lines.
  
  
  METHODS
  Here we examined, by immunohistochemical assay, the ApoD expression in normal, benign and malignant prostate tissues.
  
  
  RESULTS
  ApoD was detected in the two analyzed normal prostate tissues, in 16 (94.1%) of 17 benign prostatic hyperplasias, and in 36 (63.1%) of 57 prostate carcinomas. In prostate carcinomas, ApoD immunostaining values did not show significant relationship neither with age of the patients, stage and histologic grade of the tumors, nor with preoperative serum levels of prostatic specific antigen (PSA). However, ApoD-negative immunostaining predicted shorter survival duration in the subgroup of 46 patients with nonresectable prostate cancer (p = 0.02).
  
  
  CONCLUSIONS
  Our results led us to consider that Apo D expression by prostate carcinomas migth be of clinical usefulness for identificating lesions with different evolution.
authors.affiliation: Servicio de Cirugía General Hospital de Jove, Avda. Eduardo Castro s/n 33290 Gijón, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Díaz
authors.forename: L O
authors.initials: LO
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.forename: M T
authors.initials: MT
authors.lastname: Sánchez
authors.forename: A M
authors.initials: AM
authors.lastname: Merino
authors.forename: F
authors.initials: F
authors.lastname: Vizoso
mesh_terms: D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000378:metabolism*; D053399:Apolipoproteins D; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000401:mortality; D013997:Time Factors
chemical_list: D001053:Apolipoproteins; D053399:Apolipoproteins D; D015415:Biomarkers