Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease.
13 cases of osteomyelitis caused by Aspergillus nidulans have been previously reported in patients with chronic granulomatous disease (CGD). All of them have been associated with simultaneous pulmonary infection and have had an extremely poor outcome. We report an unusual case of femoral osteomyelitis due to A. nidulans in a 16-year-old male with CGD, without pulmonary involvement. Treatment with liposomal amphotericin B and granulocyte colony-stimulating factor as well as extensive surgical debridement followed by prolonged treatment with itraconazole resulted in an excellent clinical response.
Dotis
J
J
Third Dept. of Pediatrics, Aristotle University of Thessaloniki, Hippokration Hospital, Konstantinoupoleos 49, GR-54642 Thessaloniki, Greece.
Panagopoulou
P
P
Filioti
J
J
Winn
R
R
Toptsis
C
C
Panteliadis
C
C
Roilides
E
E
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D001233:Aspergillus nidulans / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D005269:Femur; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
D000666:Amphotericin B