Severe hyperphosphatemia resulting from high-dose liposomal amphotericin in a child with leukemia.
Children with acute lymphoblastic leukemia (ALL) are at risk for serious electrolyte abnormalities. The authors report their experience in managing a child with ALL who developed severe hyperphosphatemia as a consequence of a large exogenous load of phosphorus from high-dose liposomal amphotericin B. Health care providers need to recognize this potentially life-threatening complication of liposomal amphotericin B, since early detection and intervention can prevent significant morbidity.
Jain
Anita
A
Department of Pediatrics, University of California, Davis, California 95817, USA.
Butani
Lavjay
L
D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D002119:Calcium Carbonate / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D002481:Cellulitis / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D004337:Drug Carriers / Q000009:adverse effects; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D008081:Liposomes / Q000009:adverse effects* / Q000737:chemistry; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy*; D009916:Orbital Diseases / Q000188:drug therapy* / Q000382:microbiology; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000009:adverse effects*; D010715:Phosphatidylglycerols / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012008:Recurrence; D012640:Seizures / Q000209:etiology; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology; D014807:Vitamin D / Q000097:blood
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D010281:Parathyroid Hormone; D010710:Phosphates; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D014807:Vitamin D; D017964:Itraconazole; C084352:distearoyl phosphatidylglycerol; D000666:Amphotericin B; D002119:Calcium Carbonate