The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury.
The relationship between the hepatic ischemia/reperfusion (I/R) injury and the balance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretreated with several tool drugs. In the acute phase of hepatic I/R injury, the ratio of plasma NO/ET was reduced from 1.58 +/- 0.20 to 0.29 +/- 0.05 (P < 0.01) and the hepatic damage deteriorated. NO donor L-Arg and ET receptor antagonist TAK-044 could alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibitor L-NAME aggravated the damage. It was concluded that the hepatic I/R injury might be related with the disturbance of the NO/ET balance. Regulation of this balance might have an effect on the I/R injury.
Lü
Ping
P
Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Chen
Daoda
D
Tian
Yuan
Y
Zhang
Jinghui
J
Wu
Yihua
Y
D000818:Animals; D001120:Arginine; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000097:blood*; D005260:Female; D008099:Liver / Q000098:blood supply*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D015427:Reperfusion Injury / Q000097:blood*
D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D009569:Nitric Oxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester