Increase in serum 1,25-dihydroxyvitamin D and hypercalcaemia in a patient with inflammatory myofibroblastic tumour.
Hypercalcaemia complicates the clinical course of a substantial number of patients with advanced cancer. This report describes a patient with an inflammatory myofibroblastic tumour in soft tissue who developed an inflammatory reaction, hypercalcaemia, and a high serum concentration of 1,25 dihydroxyvitamin D. Serum concentrations of 25-hydroxyvitamin D, parathyroid hormone, and parathyroid hormone related protein were normal. Histological examination of the tumour revealed fibrosarcoma with abundant macrophage infiltration. mRNA for 25-hydroxyvitamin D-1alpha-hydroxylase was identified in the tumoral tissue. In view of this case, inflammatory myofibroblastic tumour should be added to the list of diseases that are responsible for vitamin D mediated hypercalcaemia.
Ogose
A
A
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. aogose@med.niigata-u.ac.jp
Kawashima
H
H
Morita
O
O
Hotta
T
T
Umezu
H
H
Endo
N
N
D000368:Aged; D002117:Calcitriol / Q000097:blood*; D005354:Fibrosarcoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002117:Calcitriol