A new role for Ran in ensuring precise duplication of chromosomal DNA.
To prevent re-replication of DNA, the licensing of replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue of Cell) shows that the small GTPase Ran can directly inhibit licensing inside nuclei once CDKs are active late in the cell cycle.
Blow
J Julian
JJ
Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland.
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D064111:Minichromosome Maintenance Complex Component 2; D009687:Nuclear Proteins / Q000235:genetics; D020931:ran GTP-Binding Protein / Q000235:genetics*
D018076:DNA, Complementary; D009687:Nuclear Proteins; D064111:Minichromosome Maintenance Complex Component 2; D020931:ran GTP-Binding Protein