title: Asymmetric protonation of lithium enolates of alpha-amino acid derivatives with alpha-amino acid-based chiral Brønsted acids.
abstract: The reaction of lithium enolates of alpha-amino acid derivatives with chiral amides, easily synthesized from L-tert-leucine, gives corresponding optically active unnatural alpha-amino acid derivatives with up to 87% ee.
authors.affiliation: Graduate School of Engineering, Nagoya University, SORST, Japan Science and Technology Corporation, Chikusa 464-8603, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Futatsugi
authors.forename: Akira
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D007930:Leucine / Q000031:analogs & derivatives / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011522:Protons; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000596:Amino Acids; D004952:Esters; D009942:Organometallic Compounds; D011522:Protons; D008094:Lithium; D007930:Leucine