Ageing-related tissue-specific alterations in mitochondrial composition and function are modulated by dietary fat type in the rat.
This study investigated the way in which feeding rats with two fat sources (olive or sunflower oils) affected electron-transport components and function of mitotic (liver) and postmitotic (heart and skeletal muscle) tissues during ageing. Rats adapted the mitochondrial-membrane-lipid profile to dietary fat throughout the study, suggesting that the benefits to eat either of the two fats might be maintained lifelong. Liver was more resistant to dietary changes and ageing than heart and skeletal muscle, which showed higher levels of coenzyme Q, cytochrome b, and cytochrome a + a3 with ageing and lower cytochrome c oxidase and complex IV turnover. Dietary fat differentially modulated the response of tissues during ageing, with sunflower oil leading to the highest levels of coenzyme Q and cytochromes b and a + a3. Since high levels of cytochrome b have been related to increased age, it could be hypothesized that olive oil could lead to less aged mitochondria.
Quiles
José L
JL
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C/Ramón y Cajal 4, 18071 Granada, Spain. jlquiles@goliat.ugr.es
Martínez
Estrella
E
Ibáñez
Susana
S
Ochoa
Julio J
JJ
Martín
Yolanda
Y
López-Frías
Magdalena
M
Huertas
Jesús R
JR
Mataix
José
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003573:Cytochrome b Group / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D003576:Electron Transport Complex IV / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil; D014451:Ubiquinone / Q000378:metabolism
D003573:Cytochrome b Group; D004042:Dietary Fats, Unsaturated; D008563:Membrane Lipids; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D014451:Ubiquinone; D003576:Electron Transport Complex IV