title: Nuclear hormone receptor assays for drug discovery.
abstract: Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that control diverse aspects of growth, development and homeostasis, making them exciting and important targets for drug discovery. In this review, some of the recent advances in our understanding of NRs, and their application to the discovery of new ligands, will be discussed.
authors.affiliation: Department of Molecular & Cell Biology, Ligand Pharmaceuticals Inc, 10275 Science Center Drive, San Diego, CA 92121, USA. jrosen@ligand.com
authors.forename: Jon
authors.initials: J
authors.lastname: Rosen
authors.forename: Keith
authors.initials: K
authors.lastname: Marschke
authors.forename: Deepa
authors.initials: D
authors.lastname: Rungta
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D010600:Pharmacology / Q000379:methods*; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*
chemical_list: D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear