title: The need for targeted research into breast cancer in the elderly.
abstract: BACKGROUND
  Breast cancer is a major source of morbidity and mortality in elderly women. Despite this, many trials on which clinical practice is based have under-represented the elderly. Consequently there is little evidence to guide best practice in this age group.
  
  
  METHODS
  A search of the major literature databases was performed using the search terms 'breast cancer' and 'elderly'. Articles relevant to the treatment of breast cancer in the elderly were selected.
  
  
  RESULTS
  The elderly receive less aggressive treatment for breast cancer compared with younger patients. Primary endocrine therapy is sometimes substituted for operation, and axillary surgery, adjuvant chemotherapy and adjuvant radiotherapy are commonly omitted. Evidence for and against such treatment strategies is inadequate, making it difficult to determine what constitutes best practice.
  
  
  CONCLUSIONS
  There is a need for research to be targeted at the older age group of patients with breast cancer to enable the development of specific treatment guidelines.
authors.affiliation: Academic Surgical Oncology Unit, University of Sheffield, K Floor, Royal Hallamshire Hospital, Glossop Road, UK.
authors.forename: L
authors.initials: L
authors.lastname: Wyld
authors.forename: M W R
authors.initials: MW
authors.lastname: Reed
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001365:Axilla; D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D019317:Evidence-Based Medicine; D006801:Humans; D008197:Lymph Node Excision; D016462:Mammaplasty / Q000379:methods; D008408:Mastectomy / Q000379:methods; D009367:Neoplasm Staging; D012106:Research
chemical_list: D018931:Antineoplastic Agents, Hormonal