[Molecular and cellular mechanisms of myocardial remodeling in heart failure].
The apoptosis of smooth muscle cells, the translocation, structural and functional impairments of remaining cardiomyocytes, ventricular dilatation, and the altered extracellular matrix underlie myocardial remodeling in chronic heart failure (CHF). Among the above factors, apoptosis, which is a membrane-dependent process of programmed cell death, and cytokine derangement are of primary importance. To recognize the cytokine concept of the pathogenesis of CHF permits the clinical application of cytokine synthesis inhibitors and their functional activity.
Kremneva
L V
LV
Abaturova
O V
OV
D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology*; D020257:Ventricular Remodeling
D016207:Cytokines