title: Looking at mRNA decay pathways through the window of molecular evolution.
abstract: In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.
authors.affiliation: Robert M Bock Laboratories, 1525 Linden Drive, University of Wisconsin, Madison, Wisconsin 53706, USA. mrculber@facstaff.wisc.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Culbertson
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leeds
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D010802:Phylogeny; D020365:RNA Helicases / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D015534:Trans-Activators
chemical_list: D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; C074151:NAM7 protein, S cerevisiae; D020365:RNA Helicases; C101828:UPF1 protein, human