title: Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient.
abstract: We describe a patient who developed multi-organ failure with reactive hemophagocytic syndrome secondary to disseminated histoplasmosis 8 months after orthotopic heart transplantation. The patient responded fully to a prolonged course of therapy with amphotericin B and remains free of recurrence. Disseminated histoplasmosis and reactive hemophagocytic syndrome have rarely been described in the setting of cardiac transplantation and never before in combination.
authors.affiliation: Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA.
authors.forename: Kalil
authors.initials: K
authors.lastname: Masri
authors.forename: Niall
authors.initials: N
authors.lastname: Mahon
authors.forename: Adriana
authors.initials: A
authors.lastname: Rosario
authors.forename: Imran
authors.initials: I
authors.lastname: Mirza
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Keys
authors.forename: Norman B
authors.initials: NB
authors.lastname: Ratliff
authors.forename: Randall C
authors.initials: RC
authors.lastname: Starling
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000601:surgery*; D016027:Heart Transplantation / Q000009:adverse effects*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006660:Histoplasmosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications