title: Brief report: incubation and duration of specific symptoms at acute retroviral syndrome as independent predictors of progression to AIDS.
abstract: The incubation and duration of acute retroviral syndrome (ARS) have been associated with progression to AIDS. We assessed the independent effect of specific symptoms at ARS on the rate of progression to AIDS or a CD4+ count of <200 cells/mm3 in 70 ARS patients. The incubation and duration of ARS features were stratified on their medians. The Cox regression model was used to calculate the adjusted relative hazard (ARH) of progression. Short incubations of fever (ARH = 5.8, P = 0.004), fatigue (ARH = 2.7, P = 0.06), and myalgia (ARH = 3.8, P = 0.04) were associated with faster disease progression, as was the long duration of most symptoms (ARH range: 3.1-8.1, P < 0.03 to P < 0.001). Pathogenetic mechanisms involved in the incubation of ARS features may be associated with progression to AIDS.
authors.affiliation: Laboratory of Epidemiology and Public Health, INSERM U271, Université Claude Bernard, Edouard Herriot Hospital, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France. philipva@lyon-sud.univ-lyon1.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanhems
authors.forename: Nicolas
authors.initials: N
authors.lastname: Voirin
authors.forename: Bernard
authors.initials: B
authors.lastname: Hirschel
authors.forename: David A
authors.initials: DA
authors.lastname: Cooper
authors.forename: Jeanette
authors.initials: J
authors.lastname: Vizzard
authors.forename: Andrew
authors.initials: A
authors.lastname: Carr
authors.forename: Luc
authors.initials: L
authors.lastname: Perrin
mesh_terms: D000208:Acute Disease; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D013577:Syndrome; D013997:Time Factors