title: [Cerebral amyloid angiopathy revealed by transient ischemic events: contribution of MRI to diagnosis and pathophysiology study].
abstract: We report the case of a 72-year-old left-handed woman presenting with episodes of paresthesias of the left arm and dysarthria consistent with transient ischemic attacks. The diffusion MRI showed hypersignals of the right corona radiata suggesting recent ischemic process whereas gradient-echo MRI revealed multiple small hypointense regions consistent with petechial hemorrhages restricted to the corticosubcortical regions. Gadolinium-enhanced, T1-weighted MRI showed focal meningeal enhancement. The diagnosis of cerebral amyloid angiopathy was supported by leptomeningeal biopsy. The association of ischemic suffering, petechial haemorrhage and meningeal enhancement as demonstrated by multisequence MRI highly suggest a cerebral amyloid angiopathy.
authors.affiliation: Service d'Urgences Neurovasculaires, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Peysson
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
authors.forename: M
authors.initials: M
authors.lastname: Hermier
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D000368:Aged; D016657:Cerebral Amyloid Angiopathy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology; D004401:Dysarthria / Q000209:etiology; D017352:Echo-Planar Imaging; D004562:Electrocardiography; D005260:Female; D005682:Gadolinium; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000473:pathology; D010292:Paresthesia / Q000209:etiology
chemical_list: D005682:Gadolinium