title: [Hypofractionated radiation therapy for the treatment of malignant melanoma and squamous cell carcinoma in dogs and cats].
abstract: This study describes the experience with hypofractionated radiation therapy of squamous cell carcinoma and melanoma in dogs and cats. A total dose of 32-48 Gray (Gy) was delivered once a week in 8 Gy fractions. 34 animals in which a complete surgical excision was impossible were treated. There was no tumor detectable macroscopically in 14 patients at the beginning of radiation therapy. In 20 animals the median volume of the tumor was 9.9 cm3. The median survival times and the local tumor control of squamous cell carcinoma of the oral and nasal cavities and of the body are comparable to results which were reached with a Monday-Wednesday-Friday scheme. For the treatment of Melanoma the hypofractionated radiation therapy is first choice. There are no significant side effects. Late side effects did not occur. 88% of the owners are satisfied with this kind of treatment and would choose it again.
authors.affiliation: Institut für Versuchstierkunde, Universitätsklinikums Aachen. skinzel@ukaachen.de
authors.forename: Sylvia
authors.initials: S
authors.lastname: Kinzel
authors.forename: Sven
authors.initials: S
authors.lastname: Hein
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Stopinski
authors.forename: Johannes
authors.initials: J
authors.lastname: Koch
authors.forename: Arno
authors.initials: A
authors.lastname: Buecker
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Treusacher
authors.forename: Axel
authors.initials: A
authors.lastname: Schmachtenberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Jansen
authors.forename: Michael
authors.initials: M
authors.lastname: Eble
authors.forename: Wernen
authors.initials: W
authors.lastname: Küpper
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000401:mortality / Q000532:radiotherapy*; D002415:Cats; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D016019:Survival Analysis; D016896:Treatment Outcome