Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors.
The authors studied 16 consecutive cases of cerebral venous thrombosis (CVT). Clinical outcome was good or excellent in 14 patients. Comprehensive hypercoagulable screening was done at least 3 months after the onset of CVT, including evaluation of genetic coagulation disorders and plasma levels of homocysteine and factor VIII. This screening was positive in 12 patients (75%). An acquired prothrombotic factor was identified in 9 of these 12 patients. Elevation of factor VIII plasma level was the most common coagulation disorder (8 patients).
Cakmak
S
S
Service d'Urgences Neurovasculaires, Hôpital Neurologique, Lyon, France.
Derex
L
L
Berruyer
M
M
Nighoghossian
N
N
Philippeau
F
F
Adeleine
P
P
Hermier
M
M
Froment
J C
JC
Trouillas
P
P
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography; D004185:Disability Evaluation; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008403:Mass Screening; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
D000925:Anticoagulants; D006710:Homocysteine; D005169:Factor VIII; D006493:Heparin