title: High-grade maxillofacial osteosarcoma: evolving strategies for a curable cancer.
abstract: Maxillofacial osteosarcoma is a rare tumour. Curative treatment strategies have evolved to include chemotherapy in addition to definitive surgical resection. To review and report our experience in eight patients with maxillofacial osteosarcomas, we retrospectively reviewed eight patients with high-grade maxillofacial osteosarcoma seen over the last decade at our institution. Our results suggest that a combined surgical and chemotherapy approach provides excellent local disease control and high cure rates.
authors.affiliation: Department of Medical Oncology and Clinical Haematology, Royal Melbourne Hospital, Parkville, Victoria, Australia 3050. markRosenthal@mh.org.au
authors.forename: M A
authors.initials: MA
authors.lastname: Rosenthal
authors.forename: S
authors.initials: S
authors.lastname: Mougos
authors.forename: D
authors.initials: D
authors.lastname: Wiesenfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000401:mortality; D012516:Osteosarcoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery