title: [Ciprofloxacin in the treatment of patients with brucellosis].
abstract: With the aim to estimate the clinical and immunological efficiency of the ciprofloxacin (cifloxinal) 105 patients with acute (51), subacute (19) and chronic (35) brucellosis were studied. Control group (17 patients with acute and 30 patients with chronic brucellosis) have been treated with combination of two antibiotics: doxycycline and rifampicin. Ciprofloxacin in a dose 500 mg bid within 14 days in acute stage and 20 days in chronic stage of disease essentially reduced duration of local inflammatory processes of brucellosis with simultaneous treatment of the chronic infection focus, provides good proximate and distant outcomes of treatment. Ciprofloxacin can be considered as an alternative drug for the treatment of brucellosis, more effective (clinically and immunologically) than a combination of two antibiotics: doxycycline and rifampicin.
authors.affiliation: Scientific Center of Hygiene and Epidemiology, Almaty State Institute of Prolonged Education, Republik of Kazakhstan, Almaty.
authors.forename: A K
authors.initials: AK
authors.lastname: Duĭsenova
authors.forename: K B
authors.initials: KB
authors.lastname: Kurmanova
authors.forename: G M
authors.initials: GM
authors.lastname: Kurmanova
mesh_terms: D000208:Acute Disease; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D017347:Brucella melitensis / Q000187:drug effects* / Q000302:isolation & purification; D002006:Brucellosis / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002939:Ciprofloxacin; D004318:Doxycycline; D012293:Rifampin