title: Synthesis and antimalarial activity of some new 1,2-dioxolane derivatives.
abstract: The synthesis of 1,2-dioxolane derivatives in two different acetophenone series, as simplified models of natural coumarins is described. 2-Acetyl-3-acetoxy-4-(3-hydroperoxy-3-methylbut-1-enyl)phenyl acetate and 2-acetyl-5-acetoxy4-(3-hydroperoxy-3-methylbut-1-enyl) phenyl acetate synthons are used as precursors to these structures. In vitro antimalarial activity of the 1,2-dioxolane derivatives has been investigated.
authors.affiliation: SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Helesbeux
authors.forename: Damien
authors.initials: D
authors.lastname: Peyronnet
authors.forename: Mehdi
authors.initials: M
authors.lastname: Labaïed
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: François
authors.initials: F
authors.lastname: Frappier
authors.forename: Denis
authors.initials: D
authors.lastname: Seraphin
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
authors.forename: Olivier
authors.initials: O
authors.lastname: Duval
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000098:Acetophenones; D000962:Antimalarials; D004148:Dioxolanes