title: Prevention of progression of interstitial lung lesions by early combination therapy with corticosteroids and cyclosporine/cyclophosphamide in two patients with amyopathic dermatomyositis.
abstract: Two patients with amyopathic dermatomyositis complicated by interstitial lung lesions were effectively treated with a combination of corticosteroids and cyclosporine and/or cyclophosphamide. A 48-year-old female patient was treated with pulse methylprednisolone and cyclosporine 2 months after onset of dermal symptoms. A 45-year-old male patient was treated with oral prednisolone and pulse cyclophosphamide 2 1/2 months after onset of dermal symptoms. Early evaluation of interstitial lung lesions and early extensive therapy may improve prognosis of interstitial lung lesions in patients with amyopathic dermatomyositis.
authors.affiliation: Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama.
authors.forename: Kota
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Isao
authors.initials: I
authors.lastname: Takeda
authors.forename: Haruyo
authors.initials: H
authors.lastname: Iwadate
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanno
authors.forename: Tomoe
authors.initials: T
authors.lastname: Nishimaki
authors.forename: Reiji
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones; D016572:Cyclosporine; D003520:Cyclophosphamide