title: Fibrolamellar hepatocellular carcinoma in children and adolescents.
abstract: BACKGROUND
  Children with hepatocellular carcinoma (HCC) were treated on a prospective, randomized trial and were then analyzed to determine whether children with the fibrolamellar (FL) histologic variant of HCC have a more favorable presentation, increased surgical resectability, greater response to therapy, and improved outcome compared with children who have typical HCC.
  
  
  METHODS
  Forty-six patients were enrolled on Pediatric Intergroup Hepatoma Protocol INT-0098 (Pediatric Oncology Group Study 8945/Children's Cancer Group Study 8881) between August 1989 and December 1992. After undergoing initial surgery or biopsy, children with Stage I HCC (n = 8 patients), Stage III HCC (n = 25 patients), and Stage IV HCC (n = 13 patients) were assigned randomly, regardless of histology, to receive treatment either with cisplatin, vincristine, and fluorouracil (n = 20 patients) or with cisplatin and continuous-infusion doxorubicin (n = 26 patients).
  
  
  RESULTS
  Ten of 46 patients (22%) had the fibrolamellar variant of HCC (FL-HCC). For the entire cohort, the estimated 5-year event free survival (EFS) rate (+/- standard deviation) was 17% +/- 6%. There was no difference in outcome among patients who were treated with either regimen. The 5-year EFS rate for patients with FL-HCC was no different the rate for patients with typical HCC (30% +/- 15% vs. 14% +/- 6%, respectively; P = 0.18), although the median survival was longer in patients with FL-HCC. There was no difference in the number of patients with advanced-stage disease, the incidence of surgical resectability at diagnosis, or the response to treatment between patients with FL-HCC and patients with typical HCC.
  
  
  CONCLUSIONS
  Children with FL-HCC do not have a favorable prognosis and do not respond any differently to current therapeutic regimens than patients with typical HCC. Children with initially resectable HCC have a good prognosis irrespective of histologic subtype, whereas outcomes are poor uniformly for children with advanced-stage disease. The use of novel chemotherapeutic agents and the incorporation of other treatment modalities are indicated to improve the dismal survival of pediatric patients with all histologic variants of advanced-stage HCC.
authors.affiliation: Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia, USA. howard.katzenstein@choa.org
authors.forename: Howard M
authors.initials: HM
authors.lastname: Katzenstein
authors.forename: Mark D
authors.initials: MD
authors.lastname: Krailo
authors.forename: Marcio H
authors.initials: MH
authors.lastname: Malogolowkin
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Ortega
authors.forename: Wenchun
authors.initials: W
authors.lastname: Qu
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Douglass
authors.forename: James H
authors.initials: JH
authors.lastname: Feusner
authors.forename: Marleta
authors.initials: M
authors.lastname: Reynolds
authors.forename: John J
authors.initials: JJ
authors.lastname: Quinn
authors.forename: Kurt
authors.initials: K
authors.lastname: Newman
authors.forename: Milton J
authors.initials: MJ
authors.lastname: Finegold
authors.forename: Joel E
authors.initials: JE
authors.lastname: Haas
authors.forename: Martha G
authors.initials: MG
authors.lastname: Sensel
authors.forename: Robert P
authors.initials: RP
authors.lastname: Castleberry
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bowman
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D015331:Cohort Studies; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D018197:Hepatoblastoma; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins; D014750:Vincristine; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil