How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?
Extracranial stereotactic radiosurgery (ESR) is now undergoing clinical investigation at numerous institutions as a treatment for solitary malignant lesions. Because there is no standard ESR technique, the same minimum dose might be applied through widely variable target dose-volume histograms. For multicenter trials of ESR or interinstitutional comparisons, a reliable index of radiobiological dose equivalency might facilitate the evaluation of dose-response relationships. Equivalent uniform dose (EUD) and tumor control probability (TCP) were considered for this application. While EUD appears more robust for the prospective description of ESR, TCP is expected to remain more valuable for a post hoc estimation of radiosensitivity parameters.
Kavanagh
B D
BD
Department of Radiation Oncology, University of Colorado Health Sciences Centers, Aurora, Colorado 80010-0510, USA. Brian.Kavanagh@uchsc.edu
Timmerman
R D
RD
Benedict
S H
SH
Wu
Q
Q
Schefter
T E
TE
Stuhr
K
K
McCourt
S
S
Newman
F
F
Cardinale
R M
RM
Gaspar
L F
LF
D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D011836:Radiation Tolerance; D011874:Radiometry / Q000379:methods* / Q000592:standards*; D016634:Radiosurgery / Q000379:methods* / Q000592:standards*; D011879:Radiotherapy Dosage / Q000592:standards*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods / Q000592:standards; D012680:Sensitivity and Specificity; D016896:Treatment Outcome