title: [Expression of beta-amyloid and tau-protein in mastocytes in Alzheimer disease].
abstract: With immunochemical assay, the expression of B-amyloid and tau-protein in the mast cells of the stomach and skin was first detected in patients with Alzheimer's disease (AD), which supports the hypothesis that AD is a systemic disease involving different organs and tissues. Verification of expression of two key peptides that participate in the pathogenesis of AD in the samples of extra-brain tissues allows B-amyloid and tau-protein to be regarded as promising markers and mast cells to be considered to the most suitable object for lifetime diagnosis of neurodegenerative diseases.
authors.affiliation: Institute of Bioregulation and Gerontology, North-Western Department, Russian Academy of Medical Sciences, 197110, Saint-Petersburg.
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Kvetnaia
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Riadnova
authors.forename: B B
authors.initials: BB
authors.lastname: Fursov
authors.forename: H
authors.initials: H
authors.lastname: Ernandes-Jago
authors.forename: J R
authors.initials: JR
authors.lastname: Blesa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism / Q000648:ultrastructure; D012720:Severity of Illness Index; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure; D013270:Stomach / Q000648:ultrastructure; D016875:tau Proteins / Q000096:biosynthesis*
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins