title: Somatic mutation: early cancer steps depend on tissue architecture.
abstract: Cells progress from a normal to a cancerous state by accumulating mutations. Recent mathematical studies show how the size of the cellular population in a local patch of tissue influences the spread of cancer-promoting mutations.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA. safrank@uci.edu
authors.forename: Steven A
authors.initials: SA
authors.lastname: Frank
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D014411:Neoplastic Stem Cells