title: Cytotoxic bis-3,4-dihydro-beta-carbolines and bis-beta-carbolines.
abstract: Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.
authors.affiliation: UMR 6013 Isolement, Structure, Transformations et Synthèse de Produits Naturels, IFR 53 Biomolécules, Faculté de Pharmacie, 51 rue Cognacq Jay, F-51096 Reims Cédex, France.
authors.forename: Wei-Qun
authors.initials: WQ
authors.lastname: Jiang
authors.forename: Catherine
authors.initials: C
authors.lastname: Charlet-Fagnère
authors.forename: Janos
authors.initials: J
authors.lastname: Sapi
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Laronze
authors.forename: Pierre
authors.initials: P
authors.lastname: Renard
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: Stéphane
authors.initials: S
authors.lastname: Léonce
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000577:Amides; D002243:Carbolines