title: A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report.
abstract: OBJECTIVE
  The objective was to investigate the presence of Helicobacter pylori with polymerase chain reaction in the sinonasal mucosa of patients with or without chronic rhinosinusitis (CRS).
  
  
  METHODS
  A prospective clinical trial.
  
  
  METHODS
  Mucosal tissue samples were collected from ethmoid cells of 12 patients with CRS and the removed mucosal part of the middle concha of 13 patients with concha bullosa who were treated surgically in our institution. DNA extracted from these samples was used for the amplification of 16S ribosomal RNA gene of H pylori by nested polymerase chain reaction.
  
  
  RESULTS
  Helicobacter pylori DNA was detected in 4 of 12 patients with CRS, but it was not detected in patients with concha bullosa. Three of four patients with positive results for H pylori had gastroesophageal reflux-related complaints.
  
  
  CONCLUSIONS
  It is possible to detect H pylori in the sinus mucosa of some patients with CRS. However, whether H pylori is a causative agent for CRS or a result of CRS is not known.
authors.affiliation: Department of Otorhinolaryngology, Ankara Research and Training Hospital, Ministry of Health, Ankara, Turkey. Ozdek@ttnet.net.tr
authors.forename: Ali
authors.initials: A
authors.lastname: Ozdek
authors.forename: Meltem Yalinay
authors.initials: MY
authors.lastname: Cirak
authors.forename: Erdal
authors.initials: E
authors.lastname: Samim
authors.forename: Unal
authors.initials: U
authors.lastname: Bayiz
authors.forename: Mustafa Asim
authors.initials: MA
authors.lastname: Safak
authors.forename: Sevgi
authors.initials: S
authors.lastname: Turet
mesh_terms: D000328:Adult; D002908:Chronic Disease; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005764:Gastroesophageal Reflux / Q000382:microbiology; D016481:Helicobacter Infections / Q000235:genetics / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000235:genetics / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D017931:DNA Primers