title: Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.
abstract: The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2'-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p < 0.001) and reached a maximum level after 7 days of exercise (p < 0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemon-gu, Seoul 130-701, South Korea.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Kim
authors.forename: H-B
authors.initials: HB
authors.lastname: Kim
authors.forename: M-H
authors.initials: MH
authors.lastname: Jang
authors.forename: B-V
authors.initials: BV
authors.lastname: Lim
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: S-S
authors.initials: SS
authors.lastname: Kim
authors.forename: E-H
authors.initials: EH
authors.lastname: Kim
authors.forename: C-J
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001973:Bromodeoxyuridine