New approaches to immunoprevention and immunotherapy of neoplasms.
The problems in the creation of vaccines for the prevention and treatment of neoplasms and the perspectives of their application are discussed. The positive and negative properties of the conjugates of the chemical carcinogens with proteins, DNA and enterotoxins, as well as the properties of the monoclonal anti-idiotype antibodies to the carcinogens are being analyzed. We are describing here a new technology of the anti-carcinogen vaccine production that we have developed. We suggest using transgenic plants and bacteria carrying the Fv-genes of antibodies for the passive immunoprevention of cancer diseases. We assume that lymphoproliferative neoplasms mainly arise from the clones carrying membrane receptors for the carcinogens. Therefor, here it is proposed to use the xenogenic anticarcinogens antibodies for the active immunotherapy of leukemia and other lymphoproliferative neoplasms.
Glushkov
Andrey N
AN
Kemerovo Scientific Center, Siberian Branch of Russian Academy of Sciences, Kemerovo, Russia. DCI@kemtel.ru
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control* / Q000628:therapy*; D030821:Plants, Genetically Modified / Q000276:immunology; D014611:Vaccination / Q000379:methods
D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines