Regulatory T cells in transplantation tolerance.
The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate..
Wood
Kathryn J
KJ
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. kathryn.wood@nds.ox.ac.uk
Sakaguchi
Shimon
S
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology; D013045:Species Specificity; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D023001:Transplantation Tolerance / Q000276:immunology*
D015704:CD4 Antigens; D007519:Isoantigens; D015375:Receptors, Interleukin-2