[Cytological and biochemical indices of induced sputum in patients with bronchial asthma and chronic obstructive bronchitis].
The aim of our research was to study the apoptotic index and the representativeness of CD95-receptor in the effector cells, in addition to estimation of the content of tumor necrosis factor-alpha in the induced sputum supernatant observed in patients with bronchial asthma and chronic obstructive bronchitis. These indices were evaluated in the disease dynamics and involves various treatment programs. The object of our research was induced sputum. The analysis has proven that apoptotic index of effector cell nuclei, representativeness of CD95-receptor and the content of tumor necrosis factor-alpha in the induced sputum differed, respectively, in patients with bronchial asthma and chronical obstructive bronchitis, and depended on the period of disease and employed treatment. The induced sputum analysis results can be used for the airway inflammation activity monitoring, with regard to these diseases and to treatment efficiency monitoring.
Nevzorova
V A
VA
Pacific Institute of Bioorganic Chemistry, Far East Branch of RAS, Vladivostok. nevzorovavera@hotmail.com
Konovalova
E N
EN
Khomenko
A V
AV
Plekhova
N G
NG
Pazych
S A
SA
D000328:Adult; D017209:Apoptosis / Q000276:immunology*; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D029481:Bronchitis, Chronic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D019084:Fluorescent Antibody Technique, Indirect; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D013183:Sputum / Q000166:cytology* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D019014:fas Receptor / Q000276:immunology
D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor