title: Lipid and protein oxidation and antioxidant function in women with mild and severe preeclampsia.
abstract: OBJECTIVE
  The aim of this study was to evaluate the lipid and protein oxidation and antioxidant function in preeclampsia patients and in normotensive pregnant women, as well as, to assess an association with the severity of the disease.
  
  
  METHODS
  The study was carried out in 30 patients with mild preeclampsia, 30 with severe preeclampsia, and in 50 normotensive pregnant women during the third trimester of pregnancy. Lipid peroxides in serum, placental and decidual tissues and serum protein carbonyls and some of the antioxidants were measured by spectrophotometric methods. One-way analysis of variance, chi-square test and Pearson correlation test were used for the statistical analyses. Logistic regression procedures were used to calculate odds ratios (OR).
  
  
  RESULTS
  Lipid peroxides in serum, placenta and decidua basalis and protein carbonyls in serum were significantly increased, and vitamin E and total carotene levels in serum were significantly decreased especially in women with severe preeclampsia compared with mild preeclampsia and controls. A significant correlation was detected between diastolic blood pressure and lipid peroxides in serum, placental and decidual tissues and serum protein carbonyls. Furthermore, there was significant correlation between antioxidant vitamins and lipid and protein oxidation products in severe preeclamptic patients. Also, logistic regression analysis showed that changes in serum, placental and decidual lipid peroxides and serum protein carbonyls, vitamin E and total carotene concentrations were significantly associated with preeclampsia.
  
  
  CONCLUSIONS
  Our findings suggest that lipid and protein oxidation may be an important factor in the pathogenesis of preeclampsia. Since antioxidant vitamins are significantly decreased in both severe and mild preeclamptic pregnants, early supplementation with antioxidants may be beneficial in preeclamptic patients.
authors.affiliation: Department of Biochemistry, Medical Faculty of Uludaeth University, 16059 Bursa, Turkey. zserdar@uludag.edu.tr
authors.forename: Zehra
authors.initials: Z
authors.lastname: Serdar
authors.forename: Esma
authors.initials: E
authors.lastname: Gür
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Colakoethullarý
authors.forename: Osman
authors.initials: O
authors.lastname: Develioethlu
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandöl
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D011225:Pre-Eclampsia / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D011506:Proteins; D008315:Malondialdehyde