Do leukotrienes increase cell viability in human intestinal epithelial cells?
In this preliminary report we present data showing that leukotrienes increase the baseline cell viability in human intestinal epithelial cells and that LTB4 partially reverses the morphological hallmarks of non-necrotic cell death induced by the COX-2 specific inhibitor NS-398. The proposed signaling mechanisms regulating these events are summarized in fig. 3. Please view the work on LT signal transduction in these cells by Thodeti et al. in this volume.
Ohd
John F
JF
Department of Laboratory Medicine, Division of Experimental Pathology, Lund University, Malmö General Hospital, Entrance 78, Malmö, SE-205 02 Sweden.
Wikström
Katarina
K
Sjölander
Anita
A
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D015289:Leukotrienes / Q000502:physiology*; D009578:Nitrobenzenes / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide