Looking at mRNA decay pathways through the window of molecular evolution.
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.
Culbertson
Michael R
MR
Robert M Bock Laboratories, 1525 Linden Drive, University of Wisconsin, Madison, Wisconsin 53706, USA. mrculber@facstaff.wisc.edu
Leeds
Peter F
PF
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D010802:Phylogeny; D020365:RNA Helicases / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D015534:Trans-Activators
D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; C074151:NAM7 protein, S cerevisiae; D020365:RNA Helicases; C101828:UPF1 protein, human