A first cyclopenta[c]thiophene dimer as a new bivalent potent cytotoxic derivative.
Application of the bivalent approach to the cyclopenta[c]thiophene series led to a potent cytotoxic dimer.
Khanh
Lan Pham
LP
Centre d'Etudes et de Recherche sur le Medicament de Normandie, UFR des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, 1, rue Vaubénard, 14032 Caen cedex, France.
Dallemagne
Patrick
P
Landelle
Henriette
H
Rault
Sylvain
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013876:Thiophenes