title: Arrays of mobile tethered vesicles on supported lipid bilayers.
abstract: We report a new system of laterally mobile, arrayed vesicles that are encoded with DNA to control tethering to fluid-supported phospholipid bilayers. The motion of individual fluorescently labeled vesicles, specifically bound, are easily visualized by fluorescence video microscopy and observed to collide reversibly on the surface. This system is an ideal model for studying interactions involving membranes, in particular integral membrane proteins.
authors.affiliation: Department of Chemistry, Stanford University, California 94305-5080, USA.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Yoshina-Ishii
authors.forename: Steven G
authors.initials: SG
authors.lastname: Boxer
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D008051:Lipid Bilayers; D008081:Liposomes; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D010713:Phosphatidylcholines