title: Neural fibrolipoma of the superficial peroneal nerve in the ankle: a case report with immunohistochemical analysis.
abstract: This report presents a case of neural fibrolipoma arising from the superficial peroneal nerve in the ankle. A 28-year-old woman was referred with a soft tissue mass in the anterior aspect of the right ankle, which had been gradually enlarging for the past 10 years. Magnetic resonance imaging showed a mass lesion, measuring approximately 8 x 3 x 2 cm, with high to partially low signal intensity on both T1- and T2-weighted images. A band of low signal intensity within the lesion, which is indicative of coexistence with the tumor and the superficial peroneal nerve, could be detected on both T1- and T2-weighted images. The patient underwent an excisional biopsy. The specimen microscopically consisted of nerve bundles and fibro-fatty proliferation with abundant collagen fibers. Immunoreactivity for CD34 antigen antibody was detected in fibrous spindle cells. This is the first report to present an immunohistochemical profile of neural fibrolipoma. Neural fibrolipoma should be considered as a differential diagnosis when a lipomatous lesion is encountered in the foot or ankle as well as in the upper extremities.
authors.affiliation: Department of Orthopaedic Surgery, Hyogo Medical Center for Adults, Akashi, Japan. akisue@med.kobe-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akisue
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kizaki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Fujita
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yoshiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurosaka
mesh_terms: D000328:Adult; D000842:Ankle / Q000473:pathology / Q000601:surgery; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008067:Lipoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010543:Peroneal Nerve / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D020427:Peroneal Neuropathies / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor