title: Effects of graded load of artificial gravity on cardiovascular functions in humans.
abstract: An artificial gravity and ergometric exercise loading device for human use was manufactured. It has the capacity of a max 2 G-load at the heart level, and a max 150 W of work-load. Eight subjects (six completed) were subjected to four repeated trials with or without 20 W ergometric exercise. Anti-G score, defined as the G-load x running time to the endpoint, was significantly higher in the exercise trials than standing trials. Heart rate (HR), mean arterial pressure (MAP), thoracic fluid index (TFI) were significantly superior during the exercise trials. Artificial gravity by centrifuge at 1.2 or 1.4 G with 40 or 60 W of ergometric workload may be an excellent countermeasure against cardiovascular deconditioning after long exposure to microgravity.
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwase
authors.forename: Qi
authors.initials: Q
authors.lastname: Fu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Narita
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takada
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Mano
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D018493:Cardiovascular Deconditioning / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D002498:Centrifugation; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D018470:Gravity, Altered; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D012143:Respiratory Physiological Phenomena; D018544:Weightlessness Countermeasures