A study of the relationship between ameloblastoma and human papilloma virus.
OBJECTIVE
The purpose of this study was to determine the relation of ameloblastoma with one of its probable etiologic factors, human papilloma virus (HPV).


METHODS
This study was carried out in a retrospective, observational, and blind manner with information forms using an exact polymerize chain reaction. Fifty paraffinated blocks of ameloblastoma tumor were compared with 50 impacted third molar follicles.


RESULTS
The results indicate that statistically the incidence of HPV positivity in the case group is significantly higher than that in the control group (P <.025). Furthermore, in determination of trace HPV type in HPV-positive samples, the incidence of type 6 HPV in the case group is significantly higher than that in the control group (P <.005). None of types 8, 11, 16, 18, 31, and 33 were observed.


CONCLUSIONS
The results of this research conclude that HPV could be regarded as a possible etiologic factor of ameloblastoma.
Namin
Abbas Khodayari
AK
Department of Oral and Maxillofacial Surgery, Taleghani Medical Health Sciences Center, Shahid Beheshti Medical Sciences University, Tehran, Iran.
Azad
Talat Mokhtari
TM
Eslami
Behnam
B
Sarkarat
Farzin
F
Shahrokhi
Mahmood
M
Kashanian
Farzaneh
F
D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000821:virology*; D016022:Case-Control Studies; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000472:pathogenicity*; D012189:Retrospective Studies
D015344:DNA Probes, HPV; D004279:DNA, Viral