title: Effects of mobile phone radiation on reproduction and development in Drosophila melanogaster.
abstract: In this report we examined the effects of a discontinuous radio frequency (RF) signal produced by a GSM multiband mobile phone (900/1,900 MHz; SAR approximately 1.4 W/kg) on Drosophila melanogaster, during the 10-day developmental period from egg laying through pupation. As found earlier with low frequency exposures, the non-thermal radiation from the GSM mobile phone increased numbers of offspring, elevated hsp70 levels, increased serum response element (SRE) DNA-binding and induced the phosphorylation of the nuclear transcription factor, ELK-1. The rapid induction of hsp70 within minutes, by a non-thermal stress, together with identified components of signal transduction pathways, provide sensitive and reliable biomarkers that could serve as the basis for realistic mobile phone safety guidelines.
authors.affiliation: Department of Pathology, Columbia University Health Sciences, 630 West 168 St. NYC, New York 10032, USA.
authors.forename: David
authors.initials: D
authors.lastname: Weisbrot
authors.forename: Hana
authors.initials: H
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.forename: Martin
authors.initials: M
authors.lastname: Blank
authors.forename: Reba
authors.initials: R
authors.lastname: Goodman
mesh_terms: D000818:Animals; D040421:Cell Phone / Q000592:standards; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology / Q000528:radiation effects*; D005260:Female; D005786:Gene Expression Regulation / Q000528:radiation effects; D017344:Genes, Insect / Q000528:radiation effects; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000528:radiation effects; D008297:Male; D010060:Ovulation / Q000528:radiation effects; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D011846:Radio Waves / Q000009:adverse effects*; D012098:Reproduction / Q000528:radiation effects; D012449:Safety; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018840:HSP70 Heat-Shock Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1