Notch3, another Notch in T cell development.
Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.
Bellavia
Diana
D
Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy.
Campese
Antonio F
AF
Vacca
Alessandra
A
Gulino
Alberto
A
Screpanti
Isabella
I
D000818:Animals; D019070:Cell Lineage; D051379:Mice; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000819:agonists / Q000502:physiology*; D000071656:Receptor, Notch3; D000074562:Receptor, Notch4; D011948:Receptors, Antigen, T-Cell / Q000037:antagonists & inhibitors / Q000276:immunology; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology*
D016328:NF-kappa B; C499374:NOTCH3 protein, human; C499373:Notch3 protein, mouse; D011518:Proto-Oncogene Proteins; D000071656:Receptor, Notch3; D000074562:Receptor, Notch4; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; C073572:Notch4 protein, mouse