Trisomy X in Philadelphia chromosome-negative cells during the course of Philadelphia chromosome-positive chronic myelocytic leukemia.
A Philadelphia chromosome-negative (Ph(-)) clone with trisomy X appeared in the bone marrow cells from a patient with Ph(+) chronic myelocytic leukemia in the chronic phase after hydroxyurea and interferon-alpha treatment.
Hishida
Asahi
A
First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. a-hishi@med.nagoya-u.ac.jp
Yamamoto
Kazuhito
K
Matsushita
Tadashi
T
Tanimoto
Mitsune
M
Saito
Hidehiko
H
Emi
Nobuhiko
N
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D041321:Chromosomes, Human, X; D002999:Clone Cells / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014314:Trisomy
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D006918:Hydroxyurea