title: Palpebral edema as a cutaneous manifestation of hyperthyroidism.
abstract: Three cases of palpebral edema associated with Graves' disease are described. These patients had unilateral edema and minimal erythema of the upper eyelid. Notable was that, histologically, dermal edema and dilation of lymphatic vessels were observed, but deposition of mucopolysaccharides was not. In 2 cases, edema of the eyelid was resistant to treatment with an antithyroid drug. Unilateral edema of the upper eyelid is an important cutaneous manifestation that indicates the presence of hyperthyroidism.
authors.affiliation: Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Japan. tetsuya.derm@tmd.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Satoh
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yokozeki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D004487:Edema / Q000150:complications* / Q000473:pathology; D004890:Erythema / Q000150:complications / Q000473:pathology; D005141:Eyelid Diseases / Q000150:complications* / Q000473:pathology; D005143:Eyelids / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D012867:Skin / Q000473:pathology