Pramipexole in comparison to l-dopa: a neuropsychological study.
Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on l-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while l-dopa did not. Moreover, pramipexole opposite to l-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.
Brusa
L
L
IRCCS Fondazione S. Lucia.
Bassi
A
A
Stefani
A
A
Pierantozzi
M
M
Peppe
A
A
Caramia
M D
MD
Boffa
L
L
Ruggieri
S
S
Stanzione
P
P
D000368:Aged; D000704:Analysis of Variance; D052160:Benzothiazoles; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D000077487:Pramipexole; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use*
D052160:Benzothiazoles; D013844:Thiazoles; D007980:Levodopa; D000077487:Pramipexole