title: Zotepine in Huntington's disease.
abstract: The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS-I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS-I of 34 points on day 7 of treatment. The patient was stable for at least 12 weeks. The improvement includes all seven categories of the UHDRS-I, especially chorea, gait and oral function. This is the first description of zotepine in HD. Our findings suggest that zotepine is useful in the treatment of HD chorea. Controlled trials of its use in HD would be welcome.
authors.affiliation: Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Bergstrasse 27, A-8021 Graz, Austria. rm.bonelli@nextra.at
authors.forename: Raphael M
authors.initials: RM
authors.lastname: Bonelli
authors.forename: Gerald
authors.initials: G
authors.lastname: Niederwieser
authors.forename: Theresa
authors.initials: T
authors.lastname: Lahousen
authors.forename: Peter
authors.initials: P
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002819:Chorea / Q000188:drug therapy; D003988:Dibenzothiepins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003988:Dibenzothiepins; C022172:zotepine