[Molecular mechanisms of vasculogenesis and angiogenesis. What regulates vascular growth?].
The basic mechanisms governing how endothelial cells, periendothelial cells, matrix molecules and blood constituents interact with each other are discussed. The many insights gained from this basic knowledge are being extended to further understand physiological and pathological features of vascular sprouting and maintenance. Understanding these basic principles that drive angiogenesis and vasculogenesis will lead to a more specific therapy of many disorders in ophthalmology and other fields, such as arteriosclerosis, tumor growth, myocardial ischemia and tissue repair.
Joussen
A M
AM
Abteilung für Netzhaut- und Glaskörperchirurgie und Zentrum für Molekulare Medizin, Universität zu Köln, Cologne. JoussenA@aol.com
Kirchhof
B
B
Gottstein
C
C
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000502:physiology; D020533:Angiogenesis Inhibitors / Q000502:physiology / Q000627:therapeutic use*; D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D001808:Blood Vessels / Q000254:growth & development; D003930:Diabetic Retinopathy / Q000503:physiopathology; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology; D005109:Extracellular Matrix / Q000502:physiology; D005128:Eye Diseases / Q000503:physiopathology*; D005134:Eye Neoplasms / Q000503:physiopathology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009024:Morphogenesis; D009369:Neoplasms / Q000098:blood supply / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D020286:Pericytes; D040262:Receptors, Vascular Endothelial Growth Factor / Q000502:physiology; D015861:Retinal Neovascularization / Q000503:physiopathology; D012178:Retinopathy of Prematurity / Q000503:physiopathology; D013234:Stem Cells; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D016228:Endothelial Growth Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D040262:Receptors, Vascular Endothelial Growth Factor