Anti-infective reconstituted bone xenograft used for primary bone grafting to repair contaminated defect in the radius in dogs.
OBJECTIVE
To investigate the effect of anti-infective reconstituted bone xenograft as a primary graft to repair a segmental with severe contamination.


METHODS
A canine model of contaminated defect of 1.5 cm in size in the radius was used, in which anti-infective reconstituted bone xenograft or reconstituted bone xenograft was implanted as a primary graft followed by internal fixation. The effectiveness of the two grafting materials in repairing a contaminated segmental defect was compared.


RESULTS
The animals which had received implant of anti-infective reconstituted bone xenograft should largely healed defects 6 months after operation while the defects implanted with reconstituted bone xenograft remained unrepaired with bone infection.


CONCLUSIONS
Besides its strong osteoinductive and osteoconductive activity, anti-infective reconstituted bone xenograft is highly antibacterial and can be used as a primary graft to repair the severely contaminated segmental defect.
Yuan
Zhi
Z
Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. orth1@fmmu.edu.cn
Zhao
Li
L
Hu
Yun-Yu
YY
Liu
Jian
J
Sun
Liang
L
Li
Dan
D
Lian
Kai
K
Lu
Rong
R
D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D015169:Colony Count, Microbial; D004285:Dogs; D005839:Gentamicins / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000601:surgery*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D014183:Transplantation, Heterologous
D005839:Gentamicins