Convenient method for determining the absolute configuration of chiral alcohols with racemic 1H NMR anisotropy reagent, M(alpha)NP acid: use of HPLC-CD detector.
A convenient method for determining the absolute configuration of chiral secondary alcohols using the racemic NMR anisotropy reagent, (+/-)-2-methoxy-2-(1-naphthyl)propionic acid [(+/-)-M(alpha)NP acid], and an HPLC-CD detector was developed. The method was successfully applied to some chiral alcohols derived from (-)-alpha-santonin.
Kasai
Yusuke
Y
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Aoba, Sendai, Japan.
Watanabe
Masataka
M
Harada
Nobuyuki
N