Biological activity of some monocyclic- and bicyclic beta-lactams with specified functional groups.
This Review contains our recent studies on evaluation of biological activities associated with monocyclic beta-lactams and bicyclic beta-lactam antibiotics containing various heteroatoms. A series of bicyclic beta-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These beta-lactams exhibited enhanced antibacterial activity.
Hwu
Jih Ru
JR
Organosilicon and Synthesis Laboratory, Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan 11529, Republic of China. jrhwu@mx.nthu.edu.tw
Ethiraj
Krishna S
KS
Hakimelahi
Gholam H
GH
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000494:pharmacology; D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology; D007769:Lactams; D010636:Phenols / Q000737:chemistry; D013329:Structure-Activity Relationship; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001643:Bridged Bicyclo Compounds; D002511:Cephalosporins; D007769:Lactams; D010636:Phenols; D047090:beta-Lactams; C027318:nocardicin