Antiplatelet activities of aporphine alkaloids isolated from leaves of Magnolia obovata.
Five aporphine alkaloids, N-acetylanonaine ( 1), N-acetylxylopine ( 2), N-formylanonaine ( 3), liriodenine ( 4), and lanuginosine ( 5) as the antiplatelet constituents, were isolated from the methanol extract of leaves of Magnolia obovata. This is the first reported occurrence of 2 and 3 from genus Magnolia and 5 was isolated from this plant for the first time. Compounds 1, 2 and 3 showed 60 approximately 264-fold stronger inhibitory effects than acetylsalicylic acid (ASA) to rat platelet aggregation induced by collagen, epinephrine, arachidonic acid (AA), or U46619.
Pyo
Mi Kyung
MK
Natural Products Research Institute, Seoul National University, Seoul, Korea.
Yun-Choi
Hye Sook
HS
Hong
Young-Jin
YJ
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000494:pharmacology*; D016718:Arachidonic Acid; D003094:Collagen; D004837:Epinephrine; D006801:Humans; D020128:Inhibitory Concentration 50; D031566:Magnolia; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D000470:Alkaloids; D001060:Aporphines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C081279:aporphine; D016718:Arachidonic Acid; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D003094:Collagen; D004837:Epinephrine