Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction.
A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87-90% e.e.
Gardiner
John M
JM
Department of Chemistry, UMIST, Sackville Street, Manchester, UK M60 1QD. john.gardiner@umist.ac.uk
Crewe
Philip D
PD
Smith
Gillian E
GE
Veal
Kenneth T
KT