title: Anticataract activity of Kohl-Chikni Dawa--a compound ophthalmic formulation of Unani medicine in alloxan-diabetic rats.
abstract: Kohl-Chikni Dawa (KCD), a compound ophthalmic formulation of Unani medicine was studied for anticataract activity in alloxan-diabetic rats. When one drop of 3% KCD solution was applied (once and twice daily) in both eyes for 90 days in alloxan-diabetic rats, a significant reduction of lens opacification was noticed. On the other hand, local application of 3% KCD solution (once and twice daily) did not reduce the blood sugar concentration in normal and alloxan-diabetic rats. Blood sugar in all the rats was estimated by glucometer and the morphological changes of the lenses were examined by slit-lamp biomicroscope before and after therapy at various time intervals for 90 days. These results suggest that the local application of 3% KCD solution possesses anticataract effect in alloxan-induced hyperglycaemic rats.
authors.affiliation: Department of Surgery, Faculty of Medicine (Unani), Hamdard University, Hamdard Nagar, New Delhi-110062, India. shadabzafar@rediffmail.com
authors.forename: T A
authors.initials: TA
authors.lastname: Siddiqui
authors.forename: Z
authors.initials: Z
authors.lastname: Shadab
authors.forename: I
authors.initials: I
authors.lastname: Nishat
authors.forename: N
authors.initials: N
authors.lastname: Ayasha
authors.forename: Z
authors.initials: Z
authors.lastname: Zehra
authors.forename: S H
authors.initials: SH
authors.lastname: Alavi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002386:Cataract / Q000209:etiology / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019367:Medicine, Unani; D009883:Ophthalmic Solutions / Q000138:chemical synthesis / Q000627:therapeutic use*; D051381:Rats
chemical_list: D001786:Blood Glucose; D009883:Ophthalmic Solutions