Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats.
Per os administration of Vilon (Lys-Glu) or Epithalon (Ala-Glu-Asp-Gly) to aged Wistar rats for 1 month significantly increased activity of membrane enzymes maltase and alkaline phosphatase in epithelial layer of the small intestine. In addition, Vilon significantly increased activity of cytosolic glycyl-L-leucine dipeptidase in the stromal and seromuscular layers of the small intestine in comparison with the control rats not treated with this agent. These findings suggest improvement of trophic and barrier functions of the small intestine and corroborate the hypothesis on the existence of not only epithelial, but also subepithelial enzymatic barrier supporting the enzyme system in the small intestine, especially in aged animals.
Khavinson
V Kh
VKh
Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
Timofeeva
N M
NM
Malinin
V V
VV
Gordova
L A
LA
Nikitina
A A
AA
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D004151:Dipeptides; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine