title: Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes.
abstract: Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P= .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.
authors.affiliation: Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute/NIH, Advanced Technology Center, Gaithersburg, MD 20892-4605, USA.
authors.forename: Eun Hwa
authors.initials: EH
authors.lastname: Choi
authors.forename: Charles B
authors.initials: CB
authors.lastname: Foster
authors.forename: James G
authors.initials: JG
authors.lastname: Taylor
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Erichsen
authors.forename: Renee A
authors.initials: RA
authors.lastname: Chen
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Veli-Jukka
authors.initials: VJ
authors.lastname: Anttila
authors.forename: Tapani
authors.initials: T
authors.lastname: Ruutu
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications* / Q000235:genetics*; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D007938:Leukemia / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D015847:Interleukin-4