Effects of carbimazole on morphology of rat adrenals.
OBJECTIVE
Study was conducted to investigate the effects of (i) carbimazole and (ii) simultaneous administration of thyroxine (thyroid hormone analogue) on the morphology of rat adrenals.


METHODS
A prospective case-control study.


METHODS
Department of Anatomy,Basic Medical Sciences Institute (BMSI), JPMC, Karachi, during a period of six weeks.


METHODS
The study was conducted on albino rats originally obtained from Charles River Breeding Laboratories, Brooklyn, Massachusetts, USA, and were cross bred, housed and maintained on balanced diet in the Animal House of BMSI, JPMC, Karachi. Eighteen adult albino rats used in the experiment were divided into three groups, i.e. A, B and C, each comprising 6 animals as control, carbimazole-treated, and carbimazole plus thyroxine-treated animals respectively. At the end of six weeks treatment all the animals were sacrificed and their adrenal glands removed, fixed, sectioned and stained with H&E and Sudan black. The histology of adrenals, width of cortex and its zones, and number of cells in different zones of cortex was studied.


RESULTS
Carbimazole affects the morphology of adult rat adrenals by decreasing the total width of cortex and its zones especially the zona fasciculata with decrease in number of cells. It also showed the increase in fat contents on Sudan black staining.


CONCLUSIONS
Carbimazole causes shrinkage of the adrenal cortex.
Sarwar
Ghulam
G
Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi.
Janjua
Muhammad Zahoor
MZ
D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D002231:Carbimazole / Q000494:pharmacology*; D016022:Case-Control Studies; D002452:Cell Count; D011446:Prospective Studies; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D013956:Antithyroid Agents; D002231:Carbimazole; D013974:Thyroxine