Cerebral venous sinus thrombosis precipitated by Graves' disease and Factor V Leiden mutation.
We report a case of simultaneous presentation of cerebral venous sinus thrombosis and thyrotoxicosis in a 28 year-old female subsequently found to have the Factor V Leiden mutation. She made an excellent neurological recovery with anticoagulation. The mode of presentation of the case was surprising, as she had no thrombotic episodes in two previous pregnancies. This suggests that thyrotoxicosis may give rise to a hypercoagulable state.
Molloy
E
E
Department of Medicine, Mid-Western Regional Hospital, Limerick, Ireland.
Cahill
M
M
O'Hare
J A
JA
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009154:Mutation; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology*
D000925:Anticoagulants; D013956:Antithyroid Agents; D002231:Carbimazole; D005165:Factor V