Occurrence of false positives during testing for antibodies to hepatitis C virus among volunteer blood donors in India.
The hepatitis C virus antibody statuses of only 11 (21.5%) of 51 initially reactive samples from volunteer blood donors could be confirmed by using additional screening and confirmatory assays; 23 (45%) were negative by all subsequent assays. Seventeen samples (33.3%) gave variable results in the different assays. The core and NS5 antigens were most immunogenic. An algorithm for serological screening of volunteer blood donors in blood banks of developing countries is suggested.
Raghuraman
Sukanya
S
Department of Clinical Virology, Christian Medical College, Vellore 632 004, Tamil Nadu, India.
Subramaniam
Thenmozhi
T
Daniel
Dolly
D
Sridharan
Gopalan
G
Abraham
Priya
P
D001782:Blood Donors; D005189:False Positive Reactions; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000175:diagnosis*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D015151:Immunoblotting; D007124:Immunoenzyme Techniques / Q000379:methods
D018937:Hepatitis C Antibodies