title: Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs.
abstract: Short-term increases in ambient air pollution have been associated with an increased incidence of acute cardiac events. We assessed the effect of inhalation exposure to concentrated ambient particles (CAPs) on myocardial ischemia in a canine model of coronary artery occlusion. Six mongrel dogs underwent thoracotomy for implantation of a vascular occluder around the left anterior descending coronary artery and tracheostomy to facilitate particulate exposure. After recovery (5-13 weeks), pairs of subjects were exposed for 6 hr/day on 3 or 4 consecutive days. Within each pair, one subject was randomly assigned to breathe CAPs on the second exposure day and filtered air at other times. The second subject breathed CAPs on the third exposure day and filtered air at other times. Immediately after each exposure, subjects underwent 5-min coronary artery occlusion. We determined ST-segment elevation, a measure of myocardial ischemia heart rate, and arrhythmia incidence during occlusion from continuous electrocardiograms. Exposure to CAPs (median, 285.7; range, 161.3-957.3 microg/m3) significantly (p = 0.007) enhanced occlusion-induced peak ST-segment elevation in precordial leads V4 (9.4 +/- 1.7 vs. 6.2 +/- 0.9 mm, CAPs vs. filtered air, respectively) and V5 (9.2 +/- 1.3 vs. 7.5 +/- 0.9 mm). ST-segment elevation was significantly correlated with the silicon concentration of the particles and other crustal elements possibly associated with urban street dust (p = 0.003 for Si). No associations were found with CAPs mass or number concentrations. Heart rate was not affected by CAPs exposure. These results suggest that exacerbation of myocardial ischemia during coronary artery occlusion may be an important mechanism of environmentally related acute cardiac events.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA. gwelleni@hsph.harvard.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Wellenius
authors.forename: Brent A
authors.initials: BA
authors.lastname: Coull
authors.forename: John J
authors.initials: JJ
authors.lastname: Godleski
authors.forename: Petros
authors.initials: P
authors.lastname: Koutrakis
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okabe
authors.forename: Sara T
authors.initials: ST
authors.lastname: Savage
authors.forename: Joy E
authors.initials: JE
authors.lastname: Lawrence
authors.forename: G G Krishna
authors.initials: GG
authors.lastname: Murthy
authors.forename: Richard L
authors.initials: RL
authors.lastname: Verrier
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D003324:Coronary Artery Disease / Q000150:complications* / Q000209:etiology*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D019570:Inhalation Exposure; D017202:Myocardial Ischemia / Q000503:physiopathology* / Q000662:veterinary; D010316:Particle Size
chemical_list: D000393:Air Pollutants