Pharmacological activities of stromata of Cordyceps scarabaecola.
The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2- generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.
Yu
K W
KW
Department of Kimchi and Food Science, Chongju National College of Science and Technology, Jeungpyung 367-701, Korea.
Kim
K M
KM
Suh
H J
HJ
D000110:Acetylcholinesterase / Q000187:drug effects*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000494:pharmacology; D002241:Carbohydrates / Q000032:analysis / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003167:Complement Activation / Q000187:drug effects*; D032661:Cordyceps / Q000737:chemistry*; D005656:Fungal Proteins / Q000032:analysis / Q000494:pharmacology; D006020:Glycopeptides / Q000032:analysis / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology; D008055:Lipids / Q000032:analysis / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D008517:Phytotherapy; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011188:Potassium / Q000032:analysis / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D002241:Carbohydrates; D005656:Fungal Proteins; D006020:Glycopeptides; D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D013481:Superoxides; D000110:Acetylcholinesterase; D011188:Potassium; D002118:Calcium