title: Amiodarone-induced torsade de pointes during bladder irrigation: an unusual presentation--a case report.
abstract: The authors present a case of early (within 4 days) development of torsade de pointes (TdP) associated with oral amiodarone therapy. Consistent with other reports this case of TdP occurred in the context of multiple exacerbating factors including hypokalemia and digoxin excess. Transient prolongation of the QT during bladder irrigation prompted the episode of TdP. It is well known that bradycardia exacerbates acquired TdP. The authors speculate that the increased vagal tone during bladder irrigation, a vagal maneuver, in the context of amiodarone therapy resulted in amiodarone-induced proarrhythmia. In the absence of amiodarone therapy, a second bladder irrigation did not induce TdP despite hypokalemia and hypomagnesemia.
authors.affiliation: New York Methodist Hospital, Brooklyn, NY 11215, USA.
authors.forename: Louis
authors.initials: L
authors.lastname: Voigt
authors.forename: James
authors.initials: J
authors.lastname: Coromilas
authors.forename: Barry I
authors.initials: BI
authors.lastname: Saul
authors.forename: John
authors.initials: J
authors.lastname: Kassotis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007507:Therapeutic Irrigation; D016171:Torsades de Pointes / Q000139:chemically induced*; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone