Galactofuranose metabolism: a potential target for antimicrobial chemotherapy.
Galactofuranose-containing glycoconjugates are present in numerous microbes, many of which are pathogenic for humans. Metabolic aspects of the monosaccharide have proven difficult to elucidate, because galactofuranose metabolites and glycoconjugates are relatively unstable during analyses. Recent advances in biochemical and genetic approaches, however, have facilitated a better understanding of galactofuranose metabolism. This review summarizes our current information on its metabolism and a few selected glycoconjugates containing this furanose.
Pedersen
L L
LL
Department of Biochemistry, University of Kentucky, Medical Center, Lexington, Kentucky 40536, USA.
Turco
S J
SJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015195:Drug Design; D005690:Galactose / Q000235:genetics / Q000378:metabolism*; D006001:Glycoconjugates / Q000235:genetics / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D007891:Leishmania / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D006001:Glycoconjugates; D005690:Galactose