title: Lymphoma as a model for chronic illness: effects on adrenocortical function testing.
abstract: Many dogs with chronic illness have serum biochemical abnormalities consistent with hyperadrenocorticism (HAC). Lymphoma (LSA) is a chronic disease of dogs. The purpose of this study was to evaluate adrenocortical screening test results in dogs with LSA to evaluate their specificity. Criteria for inclusion in the study included a diagnosis of LSA, an expected survival time of 16-56 weeks, no glucocorticoid treatment beyond 4 weeks after the initiation of chemotherapy, no evidence of HAC, and owner consent. Post-ACTH stimulation plasma cortisol concentrations (PACs), urine cortisol : creatinine (UC : Cr) ratios, and maximal left adrenal width measurements were performed at the time of LSA diagnosis before the initiation of chemotherapy and at 16, 24, 32, 40, and 52 weeks or until the loss of remission or the development of another disease. Ten dogs met the criteria for inclusion. Forty-two PACs were performed; 1 abnormal, 2 borderline, and 39 normal values were detected. Thirty-five maximal left adrenal width measurements were obtained; 0 abnormal, 5 borderline, and 30 normal measurements were detected. Thirty-six UC : Cr ratios were obtained, with 26 abnormal, 4 borderline, and 6 normal values detected and 9 of 10 dogs having at least 1 abnormal value. These data suggest that in dogs with LSA, the UC : Cr ratio frequently is abnormal and may not be a specific test for HAC, or it may be the most sensitive test for increases in cortisol secretion due to chronic illness. Maximal left adrenal width measurements and PACs were almost always normal and may be more specific for HAC or less sensitive for demonstrating chronic increases in cortisol secretion.
authors.affiliation: Veterinary Medical Teaching Hospital, University of California, School of Veterinary Medicine, Davis, CA, USA. tgieger@vet.uga.edu
authors.forename: T L
authors.initials: TL
authors.lastname: Gieger
authors.forename: E C
authors.initials: EC
authors.lastname: Feldman
authors.forename: S T
authors.initials: ST
authors.lastname: Wallack
authors.forename: G
authors.initials: G
authors.lastname: Dank
mesh_terms: D000302:Adrenal Cortex / Q000503:physiopathology*; D000304:Adrenal Cortex Function Tests / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000503:physiopathology / Q000662:veterinary; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D008223:Lymphoma / Q000188:drug therapy / Q000503:physiopathology* / Q000662:veterinary*; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents