title: Treatment with short-term, high-dose cyclosporin A in children with refractory chronic idiopathic thrombocytopenic purpura.
abstract: We report on 14 children (seven boys, seven girls) with chronic idiopathic thrombocytopenic purpura (ITP) refractory to multiple treatments, who were given a short-term therapy (range between 6 and 10 weeks) with high doses of cyclosporin A (CyA) (median, 10 mg/kg/d). Six patients experienced adverse events and one developed severe systemic mycosis during therapy. A complete response (CR) was observed in four patients and a partial response (PR) in three patients. Only the four CR patients, who were all girls, had a sustained response. These data suggest that CyA may be effective in some children with chronic symptomatic ITP.
authors.affiliation: Department of Paediatrics, Second University of Naples, Via S. Andrea delle Dame 4, 80138 Naples, Italy. silverio.perrotta@unina2.it
authors.forename: Silverio
authors.initials: S
authors.lastname: Perrotta
authors.forename: Giovanni
authors.initials: G
authors.lastname: Amendola
authors.forename: Franco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Conte
authors.forename: Francesca
authors.initials: F
authors.lastname: Rossi
authors.forename: Giovanna
authors.initials: G
authors.lastname: d'Urzo
authors.forename: Bruno
authors.initials: B
authors.lastname: Nobili
mesh_terms: D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009181:Mycoses / Q000150:complications; D010976:Platelet Count; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine