title: MUC6 is a marker of seminal vesicle-ejaculatory duct epithelium and is useful for the differential diagnosis with prostate adenocarcinoma.
abstract: The diagnosis of prostate adenocarcinoma is usually made on needle biopsies. Numerous benign lesions may mimic malignancy, especially when the focus of carcinoma is limited. The presence of seminal vesicle-ejaculatory duct epithelium on prostate biopsy is not rare and could cause confusion with adenocarcinoma. Lipochrome pigments are frequently encountered in seminal vesicle-ejaculatory duct but may be also seen in prostate adenocarcinoma. Prostate specific antigen immunostaining in difficult cases is sometimes used, but high-grade adenocarcinomas may be negative. In one previous report, MUC6 was found to be expressed in seminal vesicle but not in normal prostate. MUC6 belongs to the family of human mucin genes. So we investigated herein the immunohistochemical expression of MUC6 in prostate adenocarcinomas and seminal vesicle-ejaculatory duct. We have tested 30 prostate adenocarcinomas of various grade, 10 normal seminal vesicles, and 10 prostate adenocarcinomas invading the seminal vesicles. The tissues were fixed in 10% buffered formalin and embedded in paraffin. Immunohistochemistry was performed using the avidin-biotin-peroxidase complex technique. All adenocarcinomas and normal prostate structures tested were negative. In contrast, all seminal vesicles were diffusely immunostained with MUC6 antibody. We concluded that MUC6 is a valuable marker of seminal vesicle-ejaculatory duct and is useful for the differential diagnosis with prostate adenocarcinoma.
authors.affiliation: Department of Pathology, Faculty of Medicine, Center Hospitalier Régional et Universitaire, 59045 Lille, France. x-leroy@chru-lille.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Charles
authors.initials: C
authors.lastname: Ballereau
authors.forename: Arnauld
authors.initials: A
authors.lastname: Villers
authors.forename: Fabien
authors.initials: F
authors.lastname: Saint
authors.forename: Sebastien
authors.initials: S
authors.lastname: Aubert
authors.forename: Bernard
authors.initials: B
authors.lastname: Gosselin
authors.forename: Nicole
authors.initials: N
authors.lastname: Porchet
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Copin
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D004543:Ejaculatory Ducts; D004848:Epithelium; D005834:Genital Neoplasms, Male / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008297:Male; D055272:Mucin-6; D009077:Mucins / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D012669:Seminal Vesicles
chemical_list: D015415:Biomarkers; C524734:MUC6 protein, human; D055272:Mucin-6; D009077:Mucins