The use of low dose oral contraceptives for the management of acne.
There is compelling evidence that oral contraceptives (OCs) are effective in the management of mild-moderate acne vulgaris, as well as cumulative evidence that elevated levels of androgens in acne patients, relative to appropriate controls, are an underlying pathophysiological factor in acne. All low dose OCs reduce serum free testosterone (T) to a similar extent, which is contrary to the traditional concept that a patient who has acne should not use an OC containing a progestin with androgenic properties. The efficacy of various OCs to improve acne has been reported in transverse, cohort and comparative studies, and more recently in multicenter, randomized, placebo-controlled trials. Recently, an ultra-low dose OC (Alesse, Wyeth) was shown to effectively reduce non-inflammatory and inflammatory lesions in mild-to-moderate acne, while having a profile of side-effects similar to that of a placebo. Besides its contraceptive efficacy, an ultra-low dose OC represents an attractive alternative as a single or associated medication in the management of acne.
Lemay
A
A
Endocrinologie de la reproduction, Hopital St-Francois d'Assise, Department d'Obstetrique et Gynecologie, Universite Laval, Quebec, Canada.
Langley
R G
RG
D000152:Acne Vulgaris / Q000188:drug therapy*; D000726:Androgen Antagonists / Q000627:therapeutic use*; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D006801:Humans; D016912:Levonorgestrel / Q000627:therapeutic use*
D000726:Androgen Antagonists; D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D016912:Levonorgestrel