Intracerebroventricular administration of NPY stimulates resistin gene expression in mice.
Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY administration. Administered NPY (1 nmol/mouse) significantly increased resistin mRNA expression in WAT by 72% compared with artificial cerebrospinal fluid treated controls. These observations indicate that NPY might have a role in regulating resistin gene expression in WAT and that the novel brain-fat axis might be involved in the pathogenesis of obesity and related diseases.
Yuzuriha
Hideki
H
Division of Diabetes, Digestive and kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan.
Inui
Akio
A
Goto
Kyoko
K
Asakawa
Akihiro
A
Fujimiya
Mineko
M
Kasuga
Masato
M
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002552:Cerebral Ventricles; D005786:Gene Expression Regulation; D006729:Hormones, Ectopic / Q000235:genetics* / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008845:Microinjections; D020932:Nerve Growth Factor; D009478:Neuropeptide Y / Q000008:administration & dosage*; D011506:Proteins; D012333:RNA, Messenger / Q000378:metabolism; D052243:Resistin
D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D009478:Neuropeptide Y; D011506:Proteins; D012333:RNA, Messenger; D052243:Resistin; C499623:Retn protein, mouse; C413576:Retnla protein, mouse; D020932:Nerve Growth Factor