title: [Functionalization of oligonucleotides containing internucleotide phosphoamide bonds].
abstract: A new method for functionalization of oligonucleotides by addition of aminoalkyl derivatives to the intermolecular phosphorus atom of the oligonucleotide N3'-P5' phosphoramidate bond in the presence of triphenylphosphine, 4-dimethylaminopyridine, and 2,2'-dipyridyl disulfide was suggested. The reaction proceeded with both low-molecular alkylamines (1,6-diaminohexane or N,N-dimethyl-1,3-diaminopropane) and a ligand in minor groove containing a aminoalkyl group.
authors.forename: A N
authors.initials: AN
authors.lastname: Siniakov
authors.forename: A S
authors.initials: AS
authors.lastname: Butorin
authors.forename: D S
authors.initials: DS
authors.lastname: Novopashina
authors.forename: L
authors.initials: L
authors.lastname: Halby
authors.forename: V A
authors.initials: VA
authors.lastname: Riabinin
mesh_terms: D000577:Amides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D009841:Oligonucleotides; D009943:Organophosphorus Compounds