Clonal dissemination of Yersinia enterocolitica strains with various susceptibilities to nalidixic acid.
Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 microg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalidixic acid.
Sánchez-Céspedes
Javier
J
Servei de Microbiologia, Institut Clínic Infeccions i Immunología, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.
Navia
Margarita M
MM
Martínez
Rocío
R
Orden
Beatriz
B
Millán
Rosario
R
Ruiz
Joaquín
J
Vila
Jordi
J
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001483:Base Sequence; D027081:DNA Gyrase / Q000235:genetics*; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D015009:Yersinia Infections / Q000453:epidemiology / Q000382:microbiology; D015008:Yersinia enterocolitica / Q000187:drug effects / Q000235:genetics*
D000890:Anti-Infective Agents; D009268:Nalidixic Acid; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase