title: Continuous growth of mean tumor diameter in a subset of grade II gliomas.
abstract: Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.
authors.affiliation: Fédération de Neurologie Mazarin and INSERM U495, and Service de Neurochirurgie, Hôpital de la Salpêtrière (AP-HP), Paris.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mandonnet
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Tanguy
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Swanson
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Carpentier
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Philippe
authors.initials: P
authors.lastname: Cornu
authors.forename: Rémy
authors.initials: R
authors.lastname: Van Effenterre
authors.forename: Ellsworth C
authors.initials: EC
authors.lastname: Alvord
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D002455:Cell Division; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000473:pathology*; D012189:Retrospective Studies