Effect of alcoholic intoxication on water content and activity of Na,K-ATPase and Ca-ATPase in rat brain.
We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition.
Zamai
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TN
Department of Human and Animal Biochemistry and Physiology, Krasnoyarsk State University, Russia. zamay@academ.ru
Titova
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Zamai
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Usol'tseva
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Yulenkova
O V
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Shumkova
D A
DA
D000435:Alcoholic Intoxication / Q000209:etiology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
D014867:Water; D000431:Ethanol; D008315:Malondialdehyde; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase