Dipeptidyl peptidase IV gene family. The DPIV family.
We have identified three novel members of the DPIV gene family using database mining approaches. Recombinant DP8 shares a post-proline dipeptidyl aminopeptidase activity with the closely related enzymes DPIV and FAP. The similarities between DP8, DP9 and DPIV in tissue expression pattern suggest a potential role for DP8 and DP9 in liver disease, T cell activation and immune function. The role of the two novel enzymes DP8 and DP9 and the other non-enzyme member DPL2 in human disease will be the focus of further studies.
Chen
Tong
T
School of Biological Sciences, Flinders University of South Australia, Adelaide, Australia.
Ajami
Katerina
K
McCaughan
Geoffrey W
GW
Gorrell
Mark D
MD
Abbott
Catherine A
CA
D018819:Dipeptidyl Peptidase 4 / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D007438:Introns; D007700:Kinetics; D005810:Multigene Family / Q000235:genetics*
D018819:Dipeptidyl Peptidase 4