title: Neoadjuvant chemotherapy with ifosfamide and cisplatin combination in advanced head and neck cancer: a retrospective analysis of 519 patients: a single institution experience.
abstract: Advanced head and neck cancer is a major therapeutic problem in India. Ifosfamide has shown significant activity as a single agent in head and neck squamous carcinoma. In this study, we present our experience with two cycles of ifosfamide and cisplatin in the neoadjuvant setting given to a total of 519 patients. The complete response rate was 20% and the overall response rate was 80%. The treatment was well tolerated, there was no need for dose reduction, and there were no life-threatening side effects. We feel that this high response rate is sufficient to warrant more studies using ifosfamide-based combinations in a neoadjuvant setting for squamous carcinoma of the head and neck.
authors.affiliation: Department of Medical and Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai, India. drvrpai@rediffmail.com
authors.forename: V R
authors.initials: VR
authors.lastname: Pai
authors.forename: A T
authors.initials: AT
authors.lastname: Mazumdar
authors.forename: C D
authors.initials: CD
authors.lastname: Deshmukh
authors.forename: A V
authors.initials: AV
authors.lastname: Bakshi
authors.forename: D M
authors.initials: DM
authors.lastname: Parikh
authors.forename: P M
authors.initials: PM
authors.lastname: Parikh
authors.forename: R C
authors.initials: RC
authors.lastname: Mistry
authors.forename: K A
authors.initials: KA
authors.lastname: Pathak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage*; D007194:India; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002945:Cisplatin; D007069:Ifosfamide