title: The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats.
abstract: The brain serotonin (5-HT) system and circulating corticosteroids are in close interaction and both implicated in the pathogenesis of affective disorders. We evaluated the effects of adrenalectomy (ADX) on 5-HT(1B) receptors mRNA expression in cerebellum, frontal cortex, striatum and hippocampus in rats, using the RNase protection assay technique. Eight weeks after bilateral adrenalectomy, 5-HT(1B) receptor mRNA levels were decreased in the cerebellum and in the frontal cortex. The expression of 5-HT(1B) receptors mRNA was unchanged in the hippocampus and in the striatum. This data indicates regional differences in the effects of long term adrenalectomy on the expression of 5-HT(1B) receptors.
authors.affiliation: Département de Physiologie, IMASSA-CERMA, BP 73, 91223 Brétigny-sur-Orge, France. mchennaoui@imassa.fr
authors.forename: M
authors.initials: M
authors.lastname: Chennaoui
authors.forename: C
authors.initials: C
authors.lastname: Drogou
authors.forename: D
authors.initials: D
authors.lastname: Gomez-Merino
authors.forename: C Y
authors.initials: CY
authors.lastname: Guezennec
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D013995:Time
chemical_list: D012333:RNA, Messenger; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin