title: Byssochlamysol, a new antitumor steroid against IGF-1-dependent cells from Byssochlamys nivea. I. Taxonomy, fermentation, isolation and biological activity.
abstract: A new antitumor steroid, byssochlamysol, was isolated from the mycelium of Byssochlamys nivea M#5187. Byssochlamysol inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells with an IC50 of 20 ng/ml, whereas serum-dependent cell growth was not inhibited by less than 10 microg/ml of byssochlamysol. This substance induced apoptosis in IGF-1-dependent Colo320DM human colon cancer cells.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Mori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
authors.forename: Maki
authors.initials: M
authors.lastname: Aihara
authors.forename: Kosuke
authors.initials: K
authors.lastname: Takatori
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D032641:Eurotiales / Q000737:chemistry*; D005285:Fermentation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids; C472758:byssochlamysol; D007334:Insulin-Like Growth Factor I