[A comparative study on safety and immunogenicity of an inactivated hepatitis A vaccine in HBsAg carriers and healthy children].
OBJECTIVE
To evaluate safety and immunogenicity of inactivated hepatitis A vaccine in HBsAg carriers and healthy children.


METHODS
One hundred and twenty-one healthy children and ten HBsAg carriers, aged 1-10 years HAV susceptible were enrolled in the study. The inactivated hepatitis A vaccine was produced by Tangshan Biogenetic Company. The dosage of the vaccine was 1000 U/Dosage and 500 U/Dosage. The vaccination schedule was six month apart for two injections. The serum anti-HAV level was detected with EIA at one month after first injection and at one and six month after the booster injection, respectively.


RESULTS
The anti-HAV appeared in all the children. One month after the booster injection, the serum anti-HAV level in children vaccinated 500 U/Dosage was 4684.9 mIU and 4535.6 mIU, respectively and in the children vaccinated 1000 U/Dosage, 5399.8 mIU and 7347.1 mIU, respectively. The anti-HAV level was not statistically different between the two groups of children. There was no adverse reaction after the vaccination. The anti-HAV level was still high one year after first injection.


CONCLUSIONS
The data indicated that the safety and immunogenicity of the domestic inactivated hepatitis A vaccine were excellent in both groups of children.
Chen
Jiangting
J
Pingshan County Health and anti-Epidemic Station, Hebei Province 050400, China.
Ren
Yinhai
Y
Wu
Wenting
W
Ma
Shoudong
S
Li
Shengping
S
Wang
Jianhong
J
Kang
Wenxue
W
Han
Lianjun
L
Gao
Shuanjing
S
Zhang
Yucheng
Y
Liu
Chongbai
C
D002648:Child; D002675:Child, Preschool; D035922:Hepatitis A Antibodies / Q000097:blood; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007114:Immunization; D007223:Infant; D015164:Vaccines, Inactivated / Q000276:immunology
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006514:Hepatitis B Surface Antigens; D015164:Vaccines, Inactivated