title: Two new carbazole alkaloids from Murraya koenigii.
abstract: Two new carbazole alkaloids named murrayanine (1) and 8,8' '-biskoenigine (2) were isolated from Murraya koenigii. The structure elucidations for 1 and 2 were carried out on the basis of 1D and 2D NMR experiments. Compound 1 was a novel carbazole alkaloid with a rare phenylpropanyl substitution. Compound 2 was a symmetrical dimer of the carbazole alkaloid koenigine and showed antiosteoporotic activity in the CAT-B model with IC(50) 1.3 microg/mL. The synthesis of 2 from koenigine was carried out through oxidative coupling using a solid state reaction.
authors.affiliation: The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China.
authors.forename: Yun-Song
authors.initials: YS
authors.lastname: Wang
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Yue-Mao
authors.initials: YM
authors.lastname: Shen
authors.forename: Xin
authors.initials: X
authors.lastname: Hong
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002401:Cathepsin B / Q000187:drug effects*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal
chemical_list: C476746:8,8' '-biskoenigine; D000470:Alkaloids; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D002227:Carbazoles; D004365:Drugs, Chinese Herbal; C041514:carbazole; C476745:murrayanine; D002401:Cathepsin B