title: Proteomic approach to apoptotic thymus maturation.
abstract: Apoptosis is an essential process for selection of T lymphocytes specific for foreign antigen in the process of mammalian thymus maturation. Proteomics, a comprehensive study of proteins expressed in a cell, will facilitate the systematic analysis of protein molecules related to such a complicated biological system. Protein expression profiles including information about protein signatures, localization and their quantitative changes with extracellular stimulations are extremely useful to construct intracellular pathway models resulting in the apoptotic cell death.
authors.affiliation: Chemistry Department, Research Division, GlaxoSmithKline KK, 43 Wadai, Tsukuba-shi, Ibaraki 300-4247, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kawakami
authors.forename: Takuya
authors.initials: T
authors.lastname: Nagata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Muraguchi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D017209:Apoptosis; D002474:Cell-Free System; D006801:Humans; D020543:Proteome; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*
chemical_list: D020543:Proteome