Synthesis and anticancer activity of 5'-phthaloylnucleosides.
A series of novel 5'-phthaloylnucleosides were synthesized via Mitsunobu reaction starting from AZT or 2'-deoxyadenosine and numerous phthalimides and their sulphur analogues-thioimides. Some of them showed significant anticancer activity.
Orzeszko
A
A
Institute of Chemistry, Agricultural University, Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl
Vilpo
J
J
Vilpo
L
L
Kamińska
B
B
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003838:Deoxyadenine Nucleotides / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010795:Phthalic Acids / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D015215:Zidovudine / Q000737:chemistry
D000970:Antineoplastic Agents; D003838:Deoxyadenine Nucleotides; D007094:Imides; D007202:Indicators and Reagents; D009705:Nucleosides; D010795:Phthalic Acids; D015215:Zidovudine