title: Antioxidative properties of coenzyme Q10 and vitamin E in exposure to xylene and gasoline and their mixture with methanol.
abstract: Exposure to a mixture of solvents in industry is still a problem particularly in industrial laboratories. In the paint and laquer industry the employees are exposed to xylene (Rx) and gasoline (Rg). The influence of xylene and gasoline or their mixture with methanol on lipid peroxidation was evaluated in the presented paper. Antioxidative properties of CoQ10 or vitamin E were also tested. It was observed that xylene caused an increase of lipid peroxidation measured as a MDA level in all used concentrations, but gasoline only in very high doses. The mixture of xylene with methanol increased significantly MDA level, whereas gasoline with methanol did not influence lipid peroxidation. The character of interaction depends on hydrocarbons dose. CoQ10 and vitamin E are effective antioxidants lowering the increased MDA level caused by xylene, gasoline or their mixture with methanol, however the dose of CoQ10 should be adjusted to the strength of oxidative stress in order to avoid disadvantageous effect. CoQ10 is a more effective antioxidant in exposure to xylene rather than gasoline, but vitamin E acts better in exposure to gasoline decreasing the MDA level.
authors.affiliation: Department of Toxicology, Wrocław Medical University, 57/59 Traugutta Str., Wrocław, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Piotrowska
authors.forename: A
authors.initials: A
authors.lastname: Długosz
authors.forename: J
authors.initials: J
authors.lastname: Pajak
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D003067:Coenzymes; D005260:Female; D005742:Gasoline / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D016877:Oxidants / Q000633:toxicity*; D011247:Pregnancy; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D014992:Xylenes / Q000037:antagonists & inhibitors* / Q000633:toxicity
chemical_list: D000393:Air Pollutants; D000975:Antioxidants; D003067:Coenzymes; D005742:Gasoline; D016877:Oxidants; D014992:Xylenes; D014451:Ubiquinone; D014810:Vitamin E; D008315:Malondialdehyde; C024989:coenzyme Q10