title: Changes in tissue factor and activated factor XII following an acute myocardial infarction were uninfluenced by high doses of n-3 polyunsaturated fatty acids.
abstract: Few data exist on the effects of n-3 polyunsaturated fatty acids (PUFAs) on the initiators and endstage products of coagulation following an acute myocardial infarction (MI). We assessed the long-term effects of n-3 PUFAs on postinfarct variations of tissue factor (TF), activated factor XII (FXIIa) and fibrin monomer (FM), and expected additional statin treatment to modify thrombogenicity. Acute MI patients (n = 300) were randomly allocated to a high dose of n-3 PUFAs or corn oil for at least one year. Plasma concentrations of TF, FXIIa and FM were unaffected by n-3 PUFAs as compared to corn oil, and were uninfluenced by additional statin treatment in subgroup analyses. TF decreased (p = 0.0001), while FXIIa increased during the first 6 weeks (p = 0.001). FM remained essentially unchanged during the entire observation period. In conclusion, TF, FXIIa and FM were unaffected by long-term treatment with high- dosed n-3 PUFAs and by additional statin treatment.
authors.affiliation: Department of Medicine, Central Hospital in Rogaland, POB 8100, 4068 Stavanger, Norway. heidi@madlalia.no
authors.forename: Heidi
authors.initials: H
authors.lastname: Grundt
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Hetland
authors.forename: Dennis W T
authors.initials: DW
authors.lastname: Nilsen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D002784:Cholesterol / Q000378:metabolism; D003314:Corn Oil / Q000494:pharmacology; D004311:Double-Blind Method; D015956:Factor XIIa / Q000096:biosynthesis*; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D005337:Fibrin / Q000096:biosynthesis; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000097:blood* / Q000378:metabolism*; D011446:Prospective Studies; D011897:Random Allocation; D013925:Thromboplastin / Q000096:biosynthesis*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C077446:Pikasol; D003314:Corn Oil; D005337:Fibrin; D013925:Thromboplastin; D002784:Cholesterol; D015956:Factor XIIa