title: Synthesis and properties of tetra(hexa)hydropyrazolo [1,2-a]pyrido[3,4-d]pyridazine derivatives.
abstract: The synthesis of tetra(hexa)hydropyrazolo[1,2-a]pyrido[3,4-d]pyridazine derivatives (14-21) and the results of pharmacological screening are described in this paper. All compounds tested were non-toxic and showed a significant analgesic action. The analgesic effects were associated with the suppression of the spontaneous locomotor activity. Furthermore most of the synthesized compounds displayed a weak antimycobacterial action in the preliminary screening.
authors.affiliation: Department of Chemistry of Drugs, Wrocław University of Medicine, Wrocław, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
authors.forename: B
authors.initials: B
authors.lastname: Filipek
authors.forename: J
authors.initials: J
authors.lastname: Sapa
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: M
authors.initials: M
authors.lastname: Szymańska
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: M
authors.initials: M
authors.lastname: Sokołowska
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D009043:Motor Activity / Q000187:drug effects; D009161:Mycobacterium / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D011720:Pyrazoles; D011724:Pyridazines