Behaviour of beta 2-adrenoceptors on lymphocytes under continuous and pulsatile tocolysis with Fenoterol.
The present study investigates the population of beta 2-receptors on lymphocytes in pregnant women with premature labor between the 29th and 34th week of pregnancy. The population of receptors on lymphocytes correlates with that on the myometrium, which is not accessible for study during pregnancy. Fourteen patients received a pulsatile tocolysis, while ten women received a continuous tocolysis with Fenoterol. Assuming an equal population of receptors in both groups before commencement of therapy, the numbers of receptors in the patients with continuous tocolysis fell to about 35% of the initial value after 72 hours. Under pulsatile tocolysis, the numbers of receptors remained unchanged for a period of three days and was still only just below 70% of the initial value by the seventh day. Our data demonstrate that continuous administration of the short-acting beta 2-agonist Fenoterol resulted in a substantial loss of beta 2-adrenoceptors on lymphocytes. In contrast, intermittent administration of the same beta 2-adrenergic agonist prevented the onset of receptor down-regulation in pregnant women with preterm labor. Further studies are required to investigate the impact of the decreased loss of beta 2-adrenoceptor density on the good clinical experience with intermittent tocolysis.
Schmidt-Rhode
Peter
P
Department of Gynecology and Obstetrics, Women's Hospital Barmbek-Finkenau.
Brunke
Björn
B
Schröer
Heinrich
H
Obert
Kirstin
K
Schlegel
Kerstin
K
Sturm
Gerhard
G
Schulz
Klaus-Dieter
KD
von Wichert
Peter
P
D004305:Dose-Response Relationship, Drug; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D007752:Obstetric Labor, Premature / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects* / Q000378:metabolism; D015145:Tocolysis / Q000379:methods; D015149:Tocolytic Agents / Q000008:administration & dosage*
D018343:Receptors, Adrenergic, beta-2; D015149:Tocolytic Agents; D005280:Fenoterol