[Dynamic variation of serum and stool level of interleukin-2, interleukin-6 and interferon-alpha in children with rotavirus enteritis and its relation to clinical manifestations].
OBJECTIVE
This study was conducted to observe dynamically the serum and stool level of IL-2, IL-6 and IFN-alpha with RV enteritis, and to analyse the relation of them and their relation to clinical manifestations.


METHODS
The double-antibody sandwich ELISA technique was applied.


RESULTS
The positive rate of RV in 119 enteritis cases was 63.0% and the peak month was November. These cytokines had different peak phases in the course of disease. The earliest cytokine which had peak phase was IFN-alpha, the last ones were serum and stool IL-2. There was a negative relation between stool IL-2 and IL-6 (P<0.01). There were positive relation between IL-2 and IFN-alpha, stool IL-6 and IFN-alpha, serum IL-2 and IL-6, stool IL-2 and the recovery time of the enteritis (P<0.01 or P<0.05). Serum and stool level of IL-2 and IFN-alpha had positive relation to the number of lymphocyte plus mononuclear cells (P<0.01 or P<0.05).


CONCLUSIONS
IL-2, IL-6 and IFN-alpha play important roles of immunoregulation in RV enteritis, and have close relation to clinical manifestations.
Qi
Tiexiong
T
Hua Bei Oil Field Hospital, Hebei 062552, China.
Xie
Lixin
L
Wang
Yongxiang
Y
Wang
Junmin
J
Chen
Huilan
H
Zhou
Lizhi
L
D004751:Enteritis / Q000097:blood* / Q000821:virology; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D012400:Rotavirus Infections / Q000097:blood*
D007376:Interleukin-2; D015850:Interleukin-6; D007371:Interferon-gamma