title: Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus.
abstract: Collective transcriptional analysis of heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus was examined by using a targeted cDNA microarray in conjunction with Northern analyses. Differential gene expression suggests that P. furiosus relies on a cooperative strategy of rescue (thermosome [Hsp60], small heat shock protein [Hsp20], and two VAT-related chaperones), proteolysis (proteasome), and stabilization (compatible solute formation) to cope with polypeptide processing during thermal stress.
authors.affiliation: Department of Chemical Engineering, North Carolina State University, Raleigh 27695-7905, USA.
authors.forename: Keith R
authors.initials: KR
authors.lastname: Shockley
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ward
authors.forename: Swapnil R
authors.initials: SR
authors.lastname: Chhabra
authors.forename: Shannon B
authors.initials: SB
authors.lastname: Conners
authors.forename: Clemente I
authors.initials: CI
authors.lastname: Montero
authors.forename: Robert M
authors.initials: RM
authors.lastname: Kelly
mesh_terms: D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism*; D015152:Blotting, Northern; D020869:Gene Expression Profiling; D019848:Gene Expression Regulation, Archaeal; D018869:Heat-Shock Response; D020411:Oligonucleotide Array Sequence Analysis; D017510:Protein Folding; D020027:Pyrococcus furiosus / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D019843:Archaeal Proteins