Highly regioselective hydrogenolysis of bis(alpha-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring.
[reaction: see text] The highly regioselective hydrogenolysis of bis(alpha-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted alpha-phenylethylamines.
Kanai
Masatomi
M
Chemical Research Center, Central Glass Co., Ltd., Kawagoe, Saitama 350-1151, Japan. mkanai@cgco.co.jp
Yasumoto
Manabu
M
Kuriyama
Yokusu
Y
Inomiya
Kenjin
K
Katsuhara
Yutaka
Y
Higashiyama
Kimio
K
Ishii
Akihiro
A