title: G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy.
abstract: A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.
authors.affiliation: Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville Tennessee 37232-6602, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Dishy
authors.forename: Simi
authors.initials: S
authors.lastname: Gupta
authors.forename: Ruth
authors.initials: R
authors.lastname: Landau
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Xie
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kim
authors.forename: Richard M
authors.initials: RM
authors.lastname: Smiley
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Byrne
authors.forename: Alastair J J
authors.initials: AJ
authors.lastname: Wood
authors.forename: C Michael
authors.initials: CM
authors.lastname: Stein
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy / Q000235:genetics / Q000502:physiology*; D015430:Weight Gain / Q000235:genetics*
chemical_list: C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins