title: A model of dengue fever.
abstract: BACKGROUND
  Dengue is a disease which is now endemic in more than 100 countries of Africa, America, Asia and the Western Pacific. It is transmitted to the man by mosquitoes (Aedes) and exists in two forms: Dengue Fever and Dengue Haemorrhagic Fever. The disease can be contracted by one of the four different viruses. Moreover, immunity is acquired only to the serotype contracted and a contact with a second serotype becomes more dangerous.
  
  
  METHODS
  The present paper deals with a succession of two epidemics caused by two different viruses. The dynamics of the disease is studied by a compartmental model involving ordinary differential equations for the human and the mosquito populations.
  
  
  RESULTS
  Stability of the equilibrium points is given and a simulation is carried out with different values of the parameters. The epidemic dynamics is discussed and illustration is given by figures for different values of the parameters.
  
  
  CONCLUSIONS
  The proposed model allows for better understanding of the disease dynamics. Environment and vaccination strategies are discussed especially in the case of the succession of two epidemics with two different viruses.
authors.affiliation: Department of Mathematics, Faculty of Sciences, Mohamed I university, Oujda-Morocco. Derouich@sciences.univ-oujda.ac.ma
authors.forename: M
authors.initials: M
authors.lastname: Derouich
authors.forename: A
authors.initials: A
authors.lastname: Boutayeb
authors.forename: E H
authors.initials: EH
authors.lastname: Twizell
mesh_terms: D000818:Animals; D009033:Culicidae; D003715:Dengue / Q000145:classification / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D003716:Dengue Virus / Q000145:classification; D004196:Disease Outbreaks / Q000517:prevention & control*; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors; D015233:Models, Statistical; D009032:Mosquito Control; D011157:Population Dynamics; D012703:Serotyping; D014611:Vaccination