title: Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.
abstract: A 28-year-old man underwent pterygium excision with a single intraoperative application of mitomycin C (0.02%) for 3 minutes. One week after the surgery, the patient developed a corneoscleral perforation with iris prolapse. To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported. Moreover, the perforation occurred despite using a minimum concentration of the drug, risk factors were absent, and the surgery was performed by an experienced surgeon. Although a single case, this report questions the safety of using an intraoperative application of mitomycin C for preventing a recurrence of pterygium.
authors.affiliation: Guru Nanak Eye Center, Maulana Azad Medical College, New Delhi, India.
authors.forename: Subhash
authors.initials: S
authors.lastname: Dadeya
authors.forename: Shibal
authors.initials: S
authors.lastname: Fatima
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D006801:Humans; D007499:Iris Diseases / Q000139:chemically induced; D008297:Male; D016685:Mitomycin / Q000009:adverse effects*; D011391:Prolapse; D011625:Pterygium / Q000188:drug therapy / Q000601:surgery*; D012590:Sclera / Q000187:drug effects*; D015422:Scleral Diseases / Q000139:chemically induced*
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin