Prognostic significance of tumor necrosis factor receptor in colorectal adenocarcinoma.
BACKGROUND
The expression pattern and prognostic impact of tumor necrosis factor receptor type 1 (TNFR1) in colorectal cancers are not known.


METHODS
Immunohistochemical evaluation of TNFR1, Ki-67 and apoptosis was performed on formalin-fixed, paraffin-embedded specimens from 56 curatively-resected Dukes' stage C-colorectal cancer patients.


RESULTS
Thirty-seven (66%) cases had a high expression and 19 (34%) cases had a low expression of TNFR1. Expression of TNFR1 had no significant correlation with any of the clinicopathological factors studied except tumor differentiation status. Patients with a high TNFR1 expression had a significantly better disease-specific survival rate than those with a low TNFR1 expression (77.8% vs. 60.3%, respectively, p = 0.0159, log-rank test). Also in the multivariate analysis, TNFR1 expression was an independent prognostic factor.


CONCLUSIONS
A high TNFR1 expression in Dukes' stage C colorectal cancer could be a favorable indicator of prognosis.
Yoshimura
Hiroshi
H
Second Department of Surgery, Shimane Medical University, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Dhar
Dipok Kumar
DK
Nakamoto
Takeru
T
Kotoh
Tsukasa
T
Takano
Masahiro
M
Soma
Gen-Ichiro
G
Nagasue
Naofumi
N
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis*; D017209:Apoptosis / Q000502:physiology; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis*; D047888:Receptors, Tumor Necrosis Factor, Type I; D013194:Staining and Labeling; D015996:Survival Rate
D015703:Antigens, CD; D019394:Ki-67 Antigen; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I