Erysod, erythrocyte superoxide dismutase preparation: effects on LPO processes and morphological changes in the viscera of rats with burns under conditions of delayed antishock infusion therapy.
Biochemical and morphological changes in the kidneys, liver, heart, and lungs were studied in rats with deep burns of 20% body surface. Erysod (0.47 mg/kg/day) added to antishock therapy notably reduced the intensity of LPO processes in tissues both in cases when infusion therapy was started immediately (by 8-20% 12 h and by 5-24% 24 h after the injury) and when this therapy was 6 h delayed (by up about 36% after 12 h). This prevented injuries to visceral organs during the acute period of thermal injury and prevented the development of burn disease.
Paramonov
B A
BA
St. Petersburg-Tekhnologiya Company, St. Petersburg, Russia. elena@tech.spb.ru
Churilova
I V
IV
Zinov'ev
E V
EV
Chebotarev
V Yu
VY
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002056:Burns / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D004912:Erythrocytes / Q000201:enzymology; D005440:Fluid Therapy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012769:Shock / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D014781:Viscera / Q000187:drug effects / Q000378:metabolism*
D000975:Antioxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase