Distribution of neuropeptide Y Y1 and Y2 receptors in the postmortem human heart.
In the present study, we present for the first time the presence and distribution of neuropeptide Y (NPY) receptors Y1 and Y2 in the human postmortem heart using specific antibodies raised against extracellular parts of the receptors. A more intensive staining against the Y2 than against the Y1 receptors was detected on both atrial and ventricular cardiomyocytes. Immunoreactivity against both receptors was identified on both conducting fibers and cardiac nerves. More vessels stained positively for the Y2 than for the Y1 receptor, but the Y1 receptors were more abundant in subendocardial than subepicardial vessels of the left ventricular wall.
Jönsson-Rylander
Ann Cathrine
AC
Department of Cell Biology and Biochemistry, AstraZeneca, 43183, Mölndal, Sweden. arnfinn.ilebekk@ioks.uio.no
Nordlander
Margareta
M
Svindland
Aud
A
Ilebekk
Arnfinn
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001808:Blood Vessels / Q000737:chemistry / Q000473:pathology; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry* / Q000473:pathology; D017476:Receptors, Neuropeptide Y / Q000032:analysis*
D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C095889:neuropeptide Y2 receptor