A novel method for liver repopulation: Heterografting of micro-liver slices in a rat model.
The field of hepatocyte transplantation is developing, with encouraging results. However, current approaches are still unsuitable for human cell therapy, and safer and more applicable methods need to be developed. We recently successfully transplanted pieces of liver tissue (slices), cut from a wild-type Fischer 344 dipeptidyl peptidase IV (DPP IV)-positive rat and introduced into the liver of a DPP IV-deficient Fischer 344 rat. One month after the procedure, positive DPP IV enzymatic activity was detected in transplanted liver slices. These results suggest that transplantation of tissue slices is feasible and safe and could serve as a promising alternative to hepatocyte transplantation.
Gur
Eyal
E
The Microsurgery Unit, Department of Plastic Surgery, Tel Aviv Sourasky Medical Center, Israel.
Deckel
Roi
R
Zvibel
Isabel
I
Brazovsky
Eli
E
Kariv
Revital
R
Brill
Shlomo
S
Halpern
Zamir
Z
Oren
Ran
R
D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics / Q000378:metabolism; D005240:Feasibility Studies; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics; D011922:Rats, Mutant Strains
D018819:Dipeptidyl Peptidase 4