title: [Initiation of DNA replication in higher eukaryotes].
abstract: In this review, of problems concerning initiation of DNA replication in higher eukaryotes is discussed, with special emphasis on the methods of replication origin mapping and biological tests for the activity of DNA replication origins in higher eukaryotes. Protein factors interacting with replication origins are considered in detail. The main events of replication initiation in higher eukaryotes are briefly analyzed. New data on the control of replication timing of large genomic regions are discussed.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia. sergey.v.razin@usa.net
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D004261:DNA Replication / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D005057:Eukaryotic Cells / Q000502:physiology*; D005656:Fungal Proteins / Q000502:physiology; D064168:Minichromosome Maintenance Complex Component 7; D009687:Nuclear Proteins / Q000502:physiology; D018741:Replication Origin
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; C101624:MCM7 protein, human; D064168:Minichromosome Maintenance Complex Component 7