Synthesis of spiro diphosphines and their application in asymmetric hydrogenation of ketones.
Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.
Xie
Jian-Hua
JH
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Wang
Li-Xin
LX
Fu
Yu
Y
Zhu
Shuo-Fei
SF
Fan
Bao-Min
BM
Duan
Hai-Feng
HF
Zhou
Qi-Lin
QL