Immunoregulatory Properties of alpha(2)-Macroglobulin.
Native and modified with ammonium ions alpha(2)-macroglobulin forms exhibit similar abilities to influence proliferative activity and secretion of immunoglobulins in cultures of human blood mononuclear cells in vitro. Effects of modified with ammonium ions alpha(2)-macroglobulin were more significant than those of native alpha(2)-macroglobulin. Revealed properties of native alpha(2)-macroglobulin could be conditioned by a partial modification of its structure with endogenous proteinases or cytokines, some of which were shown to be common affinants for both forms.
Maltseva
N. V.
NV
Central Research Laboratory, Physician Postgraduate Training Institute, Novokuznetsk, Russia.
Lykova
O. F.
OF
Konysheva
T. V.
TV
Zorina
R. M.
RM
Arhipova
S. V.
SV
Chirikova
T. S.
TS
Zorin
N. A.
NA