Electrochemical analysis and analgesic behavior of Zn(II)-baclofen complex.
The electroanalytical behavior of Zn(II)-baclofen complex has been described by direct current polarographic (DCP) method. The complex of transition metal Zn(II) with baclofen, [4-amino-3(4-chlorophenyl) butanoic acid, has been prepared and characterized on the basis of elemental analysis, IR-spectral, polarographic and amperometric studies. The metal-ligand interaction in aqueous medium has been studied polarographically at 25 degrees C and at an ionic strength of mu = 1.0 M KCl. The reduction of the complex was found to involve two electrons and of diffusion controlled nature. The analytical results indicated a 1:1 (M:L) stoichiometry for Zn(II)-baclofen complex. The results on the drug and drug-metal complex revealed that the complex is more potent as compared with the parent drug.
Jain
Swati
S
Department of Chemistry, Dr HS Gour University, 55 Gour Nagar, Sagar, MP 470003, India. soonu_1999@yahoo.com
Jain
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D000700:Analgesics / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000032:analysis* / Q000494:pharmacology; D005260:Female; D008297:Male; D011048:Polarography / Q000379:methods; D051381:Rats; D013055:Spectrophotometry, Infrared; D015032:Zinc / Q000032:analysis* / Q000494:pharmacology
D000700:Analgesics; D001418:Baclofen; D015032:Zinc