title: Spinal epidermoid tumors: novel approach to aseptic meningitis.
abstract: Intraoperative hydrocortisone irrigation of the cerebrospinal fluid pathways may reduce symptoms attributed to aseptic meningitis, which often follow the resection of epidermoid spinal tumors. Here, 20 patients undergoing surgical resection of epidermoid tumors were randomly assigned to two groups: Group I received intraoperative hydrocortisone irrigation, whereas Group II served as a control. No patient receiving hydrocortisone experienced fevers or meningismus, but nontreated patients experienced fevers (100%) and meningismus (78%). Nausea and vomiting were reduced (9%) in the treated versus untreated groups (22% vs. 11%, respectively), whereas none in the treated group noted dizziness, vertigo, or diabetes insipidus. As steroid irrigation significantly decreased the perioperative morbidity of epidermoid tumor resection, indications for intravenous steroids may become more limited, thereby reducing cost.
authors.affiliation: University of Chicago Medical Center and Pritzker School of Medicine, Chicago Illinois, USA. jkapoor1@aol.com
authors.forename: John R
authors.initials: JR
authors.lastname: Kapoor
authors.forename: Roger
authors.initials: R
authors.lastname: Kapoor
authors.forename: Cynthia
authors.initials: C
authors.lastname: Buzea
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Gropper
mesh_terms: D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D004814:Epidermal Cyst / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007278:Injections, Spinal; D008297:Male; D008582:Meningitis, Aseptic / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D007507:Therapeutic Irrigation
chemical_list: D006854:Hydrocortisone