Effect of ginseng radix on c-Fos expression in the hippocampus of streptozotocin-induced diabetic rats.
Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.
Jang
Mi-Hyeon
MH
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
Chang
Hyun-Kyung
HK
Shin
Min-Chul
MC
Lee
Taeck-Hyun
TH
Kim
Young-Pyo
YP
Kim
Ee-Hwa
EH
Kim
Chang-Ju
CJ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts