title: Prognostic factors associated with the clinical outcome of cervical intraepithelial neoplasia: a cohort study in Japan.
abstract: One hundred and eighty-five Japanese women with cervical intraepithelial neoplasia (CIN) were enrolled in this follow-up study. On the basis of the prevalence of human papillomavirus (HPV) DNA in Japanese cervical cancer patients, HPV types were categorized into three groups as follows: (1) high risk (types 16, 18, 33, 52, and 58), (2) intermediate risk (types 31, 35, 39, 51, 56, 59, 68, and 70), (3) low risk (type 6, 30, 42, 53, 54, 55, 66 and unclassified types). High-risk HPV infection was a risk factor for progression of the disease. The regression rate in the HPV negative group was higher (83.3%) than those in the HPV positive groups, but the differences in regression were no longer significant after adjustment for age and CIN grade. It is also noted that a lower cytomegalovirus IgG level and a smaller number of past pregnancies might be associated with the regression of CIN lesions.
authors.affiliation: Department of Obstetrics and Gynecology, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan. yokoyam1@post.saga-med.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Iwasaka
authors.forename: Chisato
authors.initials: C
authors.lastname: Nagata
authors.forename: Shiro
authors.initials: S
authors.lastname: Nozawa
authors.forename: Soei
authors.initials: S
authors.lastname: Sekiya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirai
authors.forename: Koji
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Sato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshiai
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Sugase
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawana
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification; D010298:Parity; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D012725:Sexual Behavior; D012907:Smoking; D016896:Treatment Outcome; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology / Q000821:virology