Updating the asymmetric osmium-catalyzed dihydroxylation (AD) mnemonic: Q2MM modeling and new kinetic measurements.
The mnemonic device for predicting stereoselectivities in the Sharp-less asymmetric dihydroxylation (AD) reaction has been updated based on extensive computational studies. Kinetic measurements from competition reactions validate the new proposal. The interactions responsible for the high stereoselectivity in the title reaction are analyzed in detail and mapped onto the mnemonic device.
Fristrup
Peter
P
Department of Chemistry, Organic Chemistry, Technical University of Denmark, Lyngby, Denmark.
Tanner
David
D
Norrby
Per-Ola
PO