title: [Association of hypersensitivity to wormwood pollen in patients with allergic rhinitis with HLA alleles polymorphism].
abstract: OBJECTIVE
  Our purpose was to determine whether alleles at one or more HLA loci are associated with hypersensitivity to wormwood pollen in patients with allergic rhinitis.
  
  
  METHODS
  By using PCR-SSP(sequence-specific primer polymerase chain reaction), we tested the frequency distribution of HLA-DQA1, DQB alleles in 41 patients with allergic rhinitis(AR) and 41 healthy controls from Beijing.
  
  
  RESULTS
  The frequency of HLA-DQA1* 0201, DQB1 * 0602 was lower in AR than in controls(24.39%, 4.88% vs 46.34%, 26.83%), and the frequency of DQA1 * 0302 was increased among patients(58.54% vs 14.63%).
  
  
  CONCLUSIONS
  HLA-DQA1 * 0201, DQB1 * 0602 alleles might confer protection against AR, and DQA1 * 0302 may be a susceptibility factor for hypersensitivity to wormwood pollen.
authors.affiliation: ENT Department of People's Hospital, Beijing University, Beijing 100044.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xing
authors.forename: Delin
authors.initials: D
authors.lastname: Yu
authors.forename: Shulan
authors.initials: S
authors.lastname: An
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019306:Artemisia / Q000276:immunology; D002648:Child; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen