title: Release kinetics of 5-fluorouracil-loaded microspheres on an experimental rat glioma.
abstract: BACKGROUND
  Biodegradable loaded systems are promising devices for controlled and sustained release of anticancer drugs to brain tumours. We investigated the influence of drug-release profiles of 5-fluorouracil-loaded microspheres designed for the treatment of malignant gliomas.
  
  
  METHODS
  2.5 mg 5-FU delivered by either fast. (1 formulation) or slow-(2 formulations) 5-FU release microspheres (MS) were tested in C6-glioma rat brains. Tumor response was assessed by T2-weighted MRI.
  
  
  RESULTS
  All treated animals, whatever the release profile considered, displayed a comparable 50% increase in life span versus controls. Delays in C6-glioma development appeared to correspond to the in vitro release periods of MS. In terms of curative prospect, complete remission was only observed in 11% of 5-FU-treated animals (4 out of 38).
  
  
  CONCLUSIONS
  Formulation was unambiguously implicated in the response observed after local delivery of 5-FU to glioma.
authors.affiliation: INSERM ERIT-M 0104, 10 rue A. Boquel, F-49100 Angers, France.
authors.forename: Valérie-Gaelle
authors.initials: VG
authors.lastname: Roullin
authors.forename: Laurent
authors.initials: L
authors.lastname: Lemaire
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Venier-Julienne
authors.forename: Nathalie
authors.initials: N
authors.lastname: Faisant
authors.forename: Florence
authors.initials: F
authors.lastname: Franconi
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoit
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008863:Microspheres; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D005472:Fluorouracil