LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.
Human cytomegalovirus infection is a major cause of morbidity after lung transplantation. LIR-1 (leucocyte immunoglobulin-like receptor-1) is an inhibitory cell surface receptor that has high affinity for an MHC class I homologue (UL18) encoded by human cytomegalovirus. We aimed to investigate whether reactivation of human cytomegalovirus affects the expression of LIR-1. We measured LIR-1 expression on peripheral blood lymphocytes from 13 lung-transplant recipients and established human cytomegalovirus load using PCR. Eight patients developed cytomegalovirus disease. The percentage of cells expressing LIR-1 increased in the patients who developed cytomegalovirus disease several weeks before viral DNA was detectable by PCR. Measurement of LIR-1 expression might allow early identification of cytomegalovirus disease in lung-transplant patients.
Berg
Louise
L
Microbiology and Tumourbiology Centre, Karolinska Institutet, Stockholm, Sweden.
Riise
Gerdt C
GC
Cosman
David
D
Bergström
Tomas
T
Olofsson
Sigvard
S
Kärre
Klas
K
Carbone
Ennio
E
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D016040:Lung Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000097:blood*; D012307:Risk Factors
D015703:Antigens, CD; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D011971:Receptors, Immunologic