In vitro evaluation of combination of terbinafine with itraconazole or amphotericin B against Zygomycota.
The combined activity in vitro of amphotericin B/terbinafine and itraconazole/terbinafine was assessed against 17 clinical isolates of Zygomycota using a checkerboard technique. Itraconazole/terbinafine combination exhibited a potent synergistic effect against the most of strains. Amphotericin B/terbinafine combination showed an indifferent interaction for Rhizopus oryzae, and an additive effect for the other species.
Gómez-López
Alicia
A
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
Cuenca-Estrella
Manuel
M
Mellado
Emilia
E
Rodríguez-Tudela
Juan L
JL
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D005260:Female; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy; D009281:Naphthalenes / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000666:Amphotericin B; D000077291:Terbinafine