title: [Prognostic factors associated with mortality in newborns with congenital diaphragmatic hernia].
abstract: The objective was to identify prognostic factors associated with mortality in newborns with congenital diaphragmatic hernia.
  
  
  METHODS
  Study design was cases and controls nested in a cohort. We studied 65 newborns. Variables analyzed included gestational age, birth weight, Apgar and Silverman scores, surgery timing, presence of pneumothorax, degree of pulmonary hypoplasia, persistent pulmonary hypertension, mean airway pressure, blood gas analysis, ventilatory indexes, and risk of death score at admission.
  
  
  RESULTS
  Median gestational age was 38 weeks and median birth weight was 2,975 g. Lung hypoplasia ranged from 20-95%. Mortality was 40%; its main cause was persistent pulmonary hypertension. In multivariate analysis significant prognostic factors were risk of death > 50% (ORa = 59, 95% Confidence interval [CI] = 9.6-361) and mean airway pressure > 13 (ORa = 6, 95% CI = 1.2-29).
  
  
  CONCLUSIONS
  Factors that influence prognosis of newborns with congenital diaphragmatic hernia are related with ventilation process as well as mortality risk score at admission to neonatal intensive care unit.
authors.affiliation: Unidad de Cuidados Intensivos Neonatales, Hospital de Pediatría, CMN Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, México, D.F. CP. 06725. hely1802@yahoo.com.mx
authors.forename: Heladia
authors.initials: H
authors.lastname: J-García
authors.forename: Silvia
authors.initials: S
authors.lastname: Aparicio-de la Luz
authors.forename: Mario
authors.initials: M
authors.lastname: Franco-Gutiérrez
authors.forename: David
authors.initials: D
authors.lastname: González-Lara
authors.forename: Héctor
authors.initials: H
authors.lastname: González-Cabello
authors.forename: Raúl
authors.initials: R
authors.lastname: Villegas-Silva
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000401:mortality*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis; D011379:Prognosis; D012123:Pulmonary Ventilation; D012307:Risk Factors