Tetracyclic triterpenoids from the leaves of Azadirachta indica and their insecticidal activities.
A new tetranortriterpenoid, meliatetraolenone [24,25,26,27-tetranor-apotirucalla-(apoeupha)-6alpha-O-methyl, 7alpha-senecioyl(7-deacetyl)-11alpha,12alpha,21,23-tetrahydroxy-21,23-epoxy-2,14,20(22)-trien-1,16-dione] (1) was isolated from the methanolic extract of fresh leaves of Azadirachta indica along with the known compound odoratone (3) which was hitherto unreported from this source. Their structures have been elucidated by spectral studies including 2D NMR. The insecticidal activities of 1 as well as those of odoratone (3) are reported. 1 and odoratone both showed mortality on fourth instar larvae of mosquitoes (Anopheles stephensi) with LC(50) values of 16 and 154 ppm, respectively.
Siddiqui
Bina Shaheen
BS
H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan. bina@khi.comsats.net.pk
Afshan
Farhana
F
Gulzar
Tahsin
T
Sultana
Razia
R
Naqvi
Syed Naeemul-Hassan
SN
Tariq
Rajput Mohammad
RM
D000818:Animals; D031601:Azadirachta; D009033:Culicidae / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D007306:Insecticides; D010936:Plant Extracts; D014315:Triterpenes