title: Molecular cytogenetic analysis of a pleuropulmonary blastoma.
abstract: We report a case of pleuropulmonary blastoma with complex cytogenetic abnormalities, including trisomy 2, trisomy 8, dup(7), der(10) t(8; 10)(q13; q22), add(17), and double minutes (dmin). Fluorescence in situ hybridization FISH analysis demonstrated TP53 deletion and amplification of MYCN; the latter has not been reported in PPB.
authors.affiliation: Cytogenetics Laboratory, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Hong
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Coffin
authors.forename: Richard
authors.initials: R
authors.lastname: Lemons
authors.forename: Bonnie
authors.initials: B
authors.lastname: Issa
authors.forename: Arthur
authors.initials: A
authors.lastname: Brothman
authors.forename: Holly
authors.initials: H
authors.lastname: Zhou
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D020732:Cytogenetic Analysis; D005260:Female; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D018202:Pulmonary Blastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014314:Trisomy; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D016159:Tumor Suppressor Protein p53