Findings in normal rats following administration of gliadorphin-7 (GD-7).
This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of beta-casomorphin-7 (betaC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow GD-7 400 microgram and betaC-7 30 microgram/kg BW. GD-7 affects only these three regions while betaC-7affects 45. FLI is prevented by Naloxone 2mg/kg BW in all regions except the GN where it is diminished 60%. betaC-7 causes bizarre behavior beginning 60s after infusion is started. GD-7 causes no behavioral change. These findings suggest GD-7 gains access to brain cells by diffusion through circumventricular organs while betaC-7 passes the BBB by carrier facilitation.
Sun
Zhongjie
Z
Departments of Medicine and Physiology, University of Florida, HSC, 32610-0204, Gainesville, FL, USA.
Cade
Robert
R
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005829:Geniculate Bodies / Q000187:drug effects* / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
D010455:Peptides; D016760:Proto-Oncogene Proteins c-fos; D009270:Naloxone; C019178:exorphins