title: [Daily rhythms of cortisol and serotonin concentrations in children with chronic viral hepatitis].
abstract: The daily rhythms of cortisol (C) and serotonin (S) concentrations were investigated in saliva of children with chronic viral hepatitis HBV and HCV. The changes in chronostructure of C and S rhythms were revealed to depend on the viral type and an intensity of the liver inflammatory process. The circadian rhythms of C and S were found to be desynchronized which was manifested as quantitative (period) and qualitative (mesor value, amplitude of oscillations, daily acro- and miniphase) changes in the rhythm. The daily rhythm of S in children with an active and inactive HBV, as well as in those with an active HCV had the circadian character with a high mesor and an amplitude of oscillations, as compared to the control group. The transformation of the S rhythm was similar to the inactive HCV. Shifts in daily acrophase of the S rhythm were established for each clinic group. Daily C rhythm was not determined in the active HBV and HCV, either. The circadian C rhythm with daily acrophase was revealed for inactive HBV; the tendency to circadian rhythm of such type was marked for inactive HCV. The mesor of the above-mentioned groups didn't differ from the control.
authors.affiliation: Institute of Pediatrics, Obstetrics and Gynecology, AMS of Ukraine, Kiev.
authors.forename: N R
authors.initials: NR
authors.lastname: Kasianchuk
authors.forename: V K
authors.initials: VK
authors.lastname: Tyshchenko
authors.forename: A H
authors.initials: AH
authors.lastname: Tsypkun
mesh_terms: D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000503:physiopathology*; D019698:Hepatitis C, Chronic / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D012463:Saliva / Q000737:chemistry; D012701:Serotonin / Q000032:analysis*
chemical_list: D012701:Serotonin; D006854:Hydrocortisone