title: Brachiocephalic vein thrombosis associated with Crohn's disease.
abstract: An association between macrovascular thrombosis and idiopathic inflammatory bowel disease has been described, although very few well-documented cases have been published. We report on a 39-year-old woman who presented with right hemifacial and upper limb edema that was shown to be due to an extensive right brachiocephalic vein thrombosis, diagnosed by magnetic resonance angiography. Laboratory findings suggested malabsorption, and a diagnosis of Crohn's disease was established. Moreover, elevation of the plasminogen activator inhibitor system was identified. This represents the first description of a spontaneous thrombosis in a patient with Crohn's disease involving the intrathoracic venous system and raises the possibility of impaired fibrinolysis being involved in the etiopathogenesis of this complication.
authors.affiliation: Second Department of Medicine, University Hospital of Santa Maria, Av Prof Egas Moniz, 1600 Lisbon, Portugal.
authors.forename: João M
authors.initials: JM
authors.lastname: Ribeiro
authors.forename: Luísa
authors.initials: L
authors.lastname: Rebocho
authors.forename: Margarida B
authors.initials: MB
authors.lastname: Lucas
authors.forename: Paula
authors.initials: P
authors.lastname: Campos
authors.forename: Rui M M
authors.initials: RM
authors.lastname: Victorino
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016121:Brachiocephalic Veins / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011859:Radiography; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin