Visualizing signals moving in cells.
Cells display a highly complex spatiotemporal organization, required to exert a wide variety of different functions, for example, detection, processing, and propagation of nerve impulses by neurons; contraction and relaxation by muscle cells; movement by leukocytes; and adsorption and secretion of nutrients and metabolites by epithelial cells lining the gut. Successful execution of these complex processes requires highly dynamic information transfer between different regions and compartments within cells. Through the development of fluorescent sensors for intracellular signaling molecules coupled with improved microscopic imaging techniques, it has now become possible to investigate signal propagation in cells with high spatial and temporal resolution.
Weijer
Cornelis J
CJ
School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee DD1 5EH, UK. c.j.weijer@dundee.ac.uk
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D002465:Cell Movement; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D003593:Cytoplasm / Q000378:metabolism* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D003952:Diagnostic Imaging; D004058:Diffusion; D031541:Fluorescence Resonance Energy Transfer; D009249:NADP / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
D009712:Nucleotides, Cyclic; D011506:Proteins; D009249:NADP