[Effect of testosterone on protein synthesis of prostate cells in hypo- and hyperprolactinemia].
The influence of testosterone on the concentration and synthesis of nuclear and cytoplasmic prostate proteins were studied in rats with hypo- and hyperprolactinemia. Hyperprolactinemia was induced by "Lactin", and the hypoprolactinemia was modelled by "Parlodel". The rats were injected with 14C-protein hydrolysate i.p. for the investigation of the proteins biosynthesis and concentration of prostate cells. The androgen inhibited catabolism of nonhistone proteins and the proteins of nuclear juice in intact rats organism. Testosterone increased the synthesis of all proteins in rats with prolactin deficiency, but this enlarge was not connected with an elevation of their concentration. Thus, we suggest that in this case the proteins disintegration may be increased. Under hyperprolactinemia the concentration of all proteins, besides nonhistone proteins, was declined that reflected the enhancement their catabolism.
Bondarenko
T V
TV
V. Danilevsky Institute of Endocrine Pathology Problems at AMS of Ukraine, Kharkov.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006966:Hyperprolactinemia / Q000378:metabolism*; D007785:Lactose / Q000494:pharmacology; D008297:Male; D009687:Nuclear Proteins / Q000096:biosynthesis; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000097:blood; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D014176:Protein Biosynthesis; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D009687:Nuclear Proteins; D011500:Protein Synthesis Inhibitors; D013739:Testosterone; D011388:Prolactin; D007785:Lactose