title: Serologic evidence of past infection with Chlamydia trachomatis, in relation to ovarian cancer.
abstract: Pelvic inflammatory disease has been inconsistently linked with ovarian cancer. We measured antibodies to Chlamydia trachomatis, to chlamydial heat shock protein (CHSP) 60, and to CHSP10, in 117 women with ovarian cancer and in 171 age- and ethnicity-matched population-based control subjects from Oahu, Hawaii. IgG antibodies to serovar D of chlamydia elementary bodies (EB) and IgG antibodies to CHSP60-1, CHSP60-2, CHSP60-3, and CHSP10 were detected using an ELISA assay. The probability of having ovarian cancer was 90% greater in women with the highest, compared with the lowest (optical density, >or =0.40 vs. <0.10), levels of chlamydia-EB antibodies (P=.05). There was also a monotonic trend (P=.09) in ovarian cancer risk associated with CHSP60-1 but not with CHSP60-2, CHSP60-3, or CHSP10. These data suggest that past or chronic persistent infection with chlamydia may be a risk factor for ovarian cancer.
authors.affiliation: Graduate School of Public Health and Pittsburgh Cancer Institute, University of Pittsburgh, 130 DeSoto Street, 517 Parran Hall, Pittsburgh, PA 15261, USA. repro@pitt.edu
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.forename: Caixia
authors.initials: C
authors.lastname: Shen
authors.forename: Robert C
authors.initials: RC
authors.lastname: Brunham
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000150:complications* / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial