Bombesin-like peptides: candidates as diagnostic and therapeutic tools.
Bombesin (BBS) is proved to have a wide variety of the pharmacologic effects, including effects on the release of gastrointestinal hormones and control of gastrointestinal motility. More recently, the role of BBS in tumor growth, cellular proliferation and inflammation has attracted attention. There is evidence that increased BBS receptor expression may be considered as a specific marker for small-cell lung cancer, colorectal adenocarcinoma, gastric and pancreatic cancer, prostate, ovarian and breast cancer, neuroblastoma, renal cell carcinoma, malignant melanoma and thyroid carcinoma. BBS expression was found to be correlated with the histological grade of the tumor. Similarly, BBS treatment significantly improves the healing of chronic gastric ulcers and ameliorates the severity of burn- or colitis-induced gut injury. Although there is much complexity still to be elucidated to understand fully the physiologic and pathologic roles of BBS-like peptides several clinical or experimental trials have addressed that circulating or tissue levels of BBS-like peptides or their receptor expression may be used as diagnostic or prognostic markers of neoplastic disease, and incorporation of BBS receptor antagonists in the treatment of human cancer could provide substantial benefit to the cancer patients. Moreover, trophic, anti-ulcerogenic and anti-inflammatory actions of exogenous BBS make this peptide a potential supplement in minimizing or reversing tissue damage against several injurious challenges. In conclusion, based on the evidence summarized herein, related to the mitogenic and anti-inflammatory effects of BBS-like peptides, further investigations are needed to derive the benefit of BBS-like peptides in pharmacologic strategies.
Yeğen
B C
BC
Department of Physiology, Marmara University School of Medicine, Haydarpaşa, Istanbul 34668, Turkey. yegen@superonline.com
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000627:therapeutic use; D001839:Bombesin / Q000378:metabolism* / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008934:Mitogens / Q000378:metabolism / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D008934:Mitogens; D001839:Bombesin