Protein-protein interactions: lessons learned.
Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.
Sharma
S K
SK
Oncology Department, Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, NJ 07901, USA. sushil.sharma@pharma.novartis.com
Ramsey
T M
TM
Bair
K W
KW
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008968:Molecular Conformation; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D009363:Neoplasm Proteins