Anaphylactic reaction to cinoxacin: report of one case associated with inferior acute myocardial infarction.
Cinoxacin is an oral synthetic antibacterial agent, of the second generation quinolones group, with excellent efficacy in respiratory, intra-abdominal, pelvic, and skin and soft tissue infections. Overall, quinolones are well tolerated drugs, although phototoxicity and photoallergenicity is well demonstrated experimentally. In this report we show you a case of a man who presented a anaphylactic reaction associated with myocardial infarction, after taking a capsule of cinoxacin. We suppose that there is a direct participation of the heart in anaphylactic reactions, because acttivated mast-cells mediators can determine cardiovascular effects. Then performed double-blind placebo controlled challenge test with an alternative drug. We did not observe any adverse immediate or late adverse reaction to this drug.
Quercia
O
O
Unità Operativa di Medicina Interna Ospedale di Faenza, Ravenna, Italy.
Rafanelli
S
S
Emiliani
F
F
Stefanini
G Francesco
GF
D042462:4-Quinolones; D000707:Anaphylaxis / Q000209:etiology*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002937:Cinoxacin / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D010292:Paresthesia / Q000139:chemically induced; D011183:Postoperative Complications / Q000188:drug therapy; D011537:Pruritus / Q000139:chemically induced; D012008:Recurrence; D014060:Tongue Diseases / Q000139:chemically induced; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D014547:Urinary Diversion; D014552:Urinary Tract Infections / Q000188:drug therapy
D042462:4-Quinolones; D000890:Anti-Infective Agents; D018836:Inflammation Mediators; D002937:Cinoxacin