title: Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution.
abstract: HLA class I molecules can be classified into supertypes associated with overlapping peptide-binding motifs and repertoires. Herein, overlaps in peptide-binding and T-cell recognition repertoires were demonstrated between mouse and human molecules. Since rodent and primate lineages separated before the current allelic variation of mouse and human class I molecules, these data demonstrate that supertypic specificities originated by convergent evolution. Phylogenetic and structural analyses demonstrated that convergent evolution also occurs amongst primates and within the human species, resulting from the selection of different pocket structures having similar specificity or independent repeated selection of the same pocket structure.
authors.affiliation: La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. alex@liai.org
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: John
authors.initials: J
authors.lastname: Sidney
authors.forename: Brian D
authors.initials: BD
authors.lastname: Livingston
authors.forename: John L
authors.initials: JL
authors.lastname: Dzuris
authors.forename: Claire
authors.initials: C
authors.lastname: Crimi
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Walker
authors.forename: Scott
authors.initials: S
authors.lastname: Southwood
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Collins
authors.forename: Austin L
authors.initials: AL
authors.lastname: Hughes
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D019143:Evolution, Molecular; D006183:H-2 Antigens / Q000235:genetics / Q000378:metabolism; D015234:HLA-A Antigens / Q000235:genetics / Q000378:metabolism; D015793:HLA-B7 Antigen / Q000235:genetics / Q000378:metabolism; D064532:Histocompatibility Antigen H-2D; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008958:Models, Molecular; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D010802:Phylogeny; D011485:Protein Binding; D013045:Species Specificity
chemical_list: D006183:H-2 Antigens; C024755:H-2K(K) antigen; D015234:HLA-A Antigens; D015793:HLA-B7 Antigen; D064532:Histocompatibility Antigen H-2D; D015395:Histocompatibility Antigens Class I; D010455:Peptides