Location, location, location.
Increasing evidence documents the co-localization of molecules involved in both the activation and de-activation (desensitization) of signal transduction, especially in G protein-coupled receptor and heterotrimeric G protein-mediated signalling. Of particular note are the recent findings regarding recruitment of cyclic nucleotide phosphodiesterase to beta-arrestin in transfected HEK293 cells and in native cardiac myocytes. Co-localization of G protein pathway signalling molecules probably contribute to both spatial and temporal regulation of signal transduction.
Insel
Paul A
PA
Department of Pharmacology, BSB 3078, University of California, San Diego, La Jolla 92093-0636, USA. pinsel@ucsd.edu
D000818:Animals; D019390:Arrestins / Q000378:metabolism; D002478:Cells, Cultured; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology; D032342:Muscle Cells / Q000378:metabolism; D009206:Myocardium / Q000166:cytology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D020239:Receptor Cross-Talk / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000071557:beta-Arrestins
D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D000071557:beta-Arrestins; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases; D020962:Heterotrimeric GTP-Binding Proteins