title: Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia.
abstract: We describe a case of relapsed pediatric pre-B acute lymphoblastic leukemia (ALL) with a simultaneous presentation of an intracerebral lymphoid mass. Cytogenetic, immunophenotypic and molecular analysis (immunoglobulin heavy chain and T-cell receptor gene rearrangements) revealed that the brain neoplasm was distinct from the relapsed leukemia. We discuss the etiology of this extremely rare event, and raise issues about the clonality of lymphoid neoplasms and the behavior of hematopoietic cells within the central nervous system (CNS).
authors.affiliation: Department of Pediatric Hematology-Oncology, New York Medical College, Munger Pavillion, Rm 110, Valhalla, NY 10595, USA.
authors.forename: Sharon P
authors.initials: SP
authors.lastname: Mayer
authors.forename: Somasundaram
authors.initials: S
authors.lastname: Jayabose
authors.forename: Oya
authors.initials: O
authors.lastname: Tugal
authors.forename: M Fevzi
authors.initials: MF
authors.lastname: Ozkaynak
authors.forename: Lynne
authors.initials: L
authors.lastname: Rosenblum-Vos
authors.forename: Claudio
authors.initials: C
authors.lastname: Sandoval
mesh_terms: D001483:Base Sequence; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D012008:Recurrence; D013997:Time Factors
chemical_list: D007143:Immunoglobulin Heavy Chains