Disarming the invader.
Type III secretion systems are used by many gram-negative bacterial pathogens of animals and plants to deliver essential virulence factors into targeted host cells. The identification of chemical compounds that block the function of these systems is the first step toward developing chemical attenuation as an effective method for the treatment of infectious disease.
Young
Glenn M
GM
Graduate Groups of Microbiology, Food Science, and Biochemistry and Molecular Biology, University of California, Davis, Davis, CA 95616, USA.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D010935:Plant Diseases / Q000382:microbiology; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C063239:yopE protein, Yersinia