Haloperidol challenge in healthy male humans: a functional magnetic resonance imaging study.
Functional magnetic resonance imaging (fMRI) was used to determine the acute blood oxygen level dependent effect (BOLD) of neuroleptic drugs in healthy male subjects. Using a robust simultaneous visuo-acoustic stimulation paradigm fMRI measurements were obtained prior to as well as 1 h and 24 h after intravenous infusion of 5 mg haloperidol to six healthy young men. After the administration, subjects showed significantly reduced BOLD contrast in the middle occipital gyrus while BOLD contrast was increased in the lingual gyrus. This pattern normalised within 24 h. Our results emphasise the necessity to control for interactions through acute medication and confirm fMRI as a non-invasive method for studying cerebral psychopharmacological effects.
Brassen
Stefanie
S
NMR Research in Psychiatry, Central Institute of Mental Health, PO Box 122 120, D-68072 Mannheim, Germany.
Tost
Heike
H
Höhn
Fabian
F
Hoehn
Fabian
F
Weber-Fahr
Wolfgang
W
Klein
Sabine
S
Braus
Dieter F
DF
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D010775:Photic Stimulation / Q000379:methods
D006220:Haloperidol