Effects of Polyoxidonium on Phagocytic Cell Functions. Experimental and Clinical Estimation of Potential Inclusion of Polyoxidonium in Complex Therapy in Penetrating Eye Injury.
The purpose of present paper is the investigation of polyoxidonium effects on the functions of circulating pool of phagocytic cells and the estimation of its potential inclusion in complex therapy in penetrating eye injuries. On experimental model of eye injuring in rats there has been established that polyoxidonium attenuated some negative glucocorticoid effects on phagocytic cells. Inclusion of polyoxidonium in complex therapy optimized the course of injuring process according to parameters of the least infiltration of damage area with immunocompetent and effector cells, scar structure and other parameters. The stimulation of neutrophil, and in a less degree of eosinophil phagocytosis, was demonstrated at concentration range from 10(-11) to 10 &mgr;g/ml under conditions of 1 h drug preincubation in vitro with blood cells of healthy people. At concentrations 10(-11)-10(-8) &mgr;g/ml polyoxidonium caused a slightly stimulated effect on the parameters of monocyte phagocytosis. As a whole the results obtained show that further studies are promising for potential use of polyoxidonium in complex therapy for penetrating eye injuries.
Chereshnev
Valery A.
VA
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
Shilov
Yuri I.
YI
Chereshneva
Margarita V.
MV
Platova
Ludmila A.
LA
Badanina
Oksana N.
ON
Osotov
Sergey V.
SV
Ponomareva
Tatyana B.
TB