FluoMar, a fluorous version of the Marshall resin for solution-phase library synthesis.
[structure: see text] The fluorous counterpart of the Marshall resin, 4-(1H,1H,2H,2H-perfluorodecylsulfanyl)phenol (FluoMar), is prepared by S-alkylation of 4-mercaptophenol with C(8)F(17)CH(2)CH(2)I and employed in the synthesis of amide and diamide analogues. The final products are purified by solid-phase extraction (SPE) over FluoroFlash silica cartridges.
Chen
Christine Hiu-Tung
CH
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, Pennsylvania 15238, USA.
Zhang
Wei
W
D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D005465:Fluorocarbon Polymers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry
D000577:Amides; D005465:Fluorocarbon Polymers; D012996:Solutions