Biologic findings of post-traumatic stress disorder and child maltreatment.
Child maltreatment is a serious problem in US society, affecting approximately three million children. Children and adolescents exposed to child abuse and neglect experience high rates of post-traumatic stress disorder (PTSD). In addition, they are at risk for comorbid mental illness. Biologic stress systems affected in trauma and in PTSD are complex. Findings in cognitive testing, neuroimaging, and affected pathways shed light on the consequences of child maltreatment. What is known about treatment and outcomes for children with history of maltreatment and maltreatment-related PTSD indicates the need for prevention, intervention, and treatment of children exposed to abuse and neglect. The following is a brief review of the most recent neurobiologic findings in child maltreatment and related PTSD.
De Bellis
Michael D
MD
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3613, Durham, NC 27710, USA. debel002@mc.duke.edu
Thomas
Lisa A
LA
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000374:Aggression / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000209:etiology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D002648:Child; D002649:Child Abuse / Q000523:psychology* / Q000706:statistics & numerical data; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology; D003866:Depressive Disorder / Q000453:epidemiology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism*; D013406:Suicide, Attempted / Q000706:statistics & numerical data
D001224:Aspartic Acid; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; C000179:N-acetylaspartate; D006854:Hydrocortisone