The Peculiarities of the Immune Status in Mice with Different Level of Behavioral Reactions.
Within the framework of the problem of neuroimmune interrelationships we studied the peculiarities of the immune status in mice with different level of behavioral reactions. The parameters of humoral and cellular immunity, immunohaematological values and thymus weight in mice were investigated. Using the "open field" we estimated the exploratory behavior, general locomotor activity and emotional state in mice. It was found that (CBA x C57Bl/6)F1 mice may be divided into 3 following groups: with high, medium and low level according to a degree of pronounced signs of behavioral reactions. C57Bl/6 and Balb/c mice appeared to be opposite towards manifestation of studied behavioral reactions. All mice showed direct dependence between the initial level of exploratory behavior, general locomotor activity and pronounced signs of delayed type hypersensitivity as well as indirect dependence of this immunological parameter on the degree of emotional state. Thus, it can be concluded that there is a close link between functional activity of nervous system and expression of cellular immunity. The influence of immune system on the formation of the initial behavioral status in mice is supposed.
Markova
Eugenia V.
EV
Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia.
Gromykhina
Natalia Yu.
NY
Abramov
Valery V.
VV
Kozlov
Vladimir A.
VA