Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia.
We describe a case of relapsed pediatric pre-B acute lymphoblastic leukemia (ALL) with a simultaneous presentation of an intracerebral lymphoid mass. Cytogenetic, immunophenotypic and molecular analysis (immunoglobulin heavy chain and T-cell receptor gene rearrangements) revealed that the brain neoplasm was distinct from the relapsed leukemia. We discuss the etiology of this extremely rare event, and raise issues about the clonality of lymphoid neoplasms and the behavior of hematopoietic cells within the central nervous system (CNS).
Mayer
Sharon P
SP
Department of Pediatric Hematology-Oncology, New York Medical College, Munger Pavillion, Rm 110, Valhalla, NY 10595, USA.
Jayabose
Somasundaram
S
Tugal
Oya
O
Ozkaynak
M Fevzi
MF
Rosenblum-Vos
Lynne
L
Sandoval
Claudio
C
D001483:Base Sequence; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D012008:Recurrence; D013997:Time Factors
D007143:Immunoglobulin Heavy Chains