title: A new automated method for the quantification of mitral regurgitant volume and dynamic regurgitant orifice area based on a normalized centerline velocity distribution using color M-mode and continuous wave Doppler imaging.
abstract: Previous echocardiographic techniques for quantifying valvular regurgitation (PISA) are limited by factors including uncertainties in orifice location and hemispheric convergence assumption. Using computational fluid dynamics simulations, we developed a new model for the estimation of orifice diameter and regurgitant volume without the aforementioned assumptions of the PISA technique. Using experimental data obtained from the in vitro flow model we successfully validated our new model. The model output (y) and reference (x) values were in close agreement (y = 0.95x + 0.38, r = 0.96, error = 1.68 +/- 7.54% for the orifice diameter and y = 1.18x - 4.72, r = 0.93, error = 6.48 +/- 16.81% for the regurgitant volume).
authors.affiliation: Cleveland Clinic Foundation, Department of Cardiology, Cardiovascular Imaging, 9500 Euclid Ave, Desk F15, Cleveland, OH 44195, USA. deserrd@ccf.org
authors.forename: Dimitri
authors.initials: D
authors.lastname: Deserranno
authors.forename: Neil L
authors.initials: NL
authors.lastname: Greenberg
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Garcia
mesh_terms: D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity