title: Treatment of multidrug-resistant tuberculosis during pregnancy: a report of 7 cases.
abstract: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem affecting women of childbearing age. Little is known, however, about the safety of the drugs used to treat MDR-TB during pregnancy. We describe 7 patients who were treated for MDR-TB during pregnancy. These patients had chronic tuberculosis that had caused extensive parenchymal damage and had high-grade resistance to antituberculous drugs. All patients received individualized antituberculous therapy prior to delivery of healthy term infants. Neither obstetrical complications nor perinatal transmission of MDB-TB was observed. One patient experienced treatment failure, and another abandoned therapy. The other 5 patients are currently cured or in treatment and have culture-negative status. In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy.
authors.affiliation: Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. sshin@partners.org
authors.forename: Sonya
authors.initials: S
authors.lastname: Shin
authors.forename: Dalia
authors.initials: D
authors.lastname: Guerra
authors.forename: Michael
authors.initials: M
authors.lastname: Rich
authors.forename: Kwonjune J
authors.initials: KJ
authors.lastname: Seung
authors.forename: Joia
authors.initials: J
authors.lastname: Mukherjee
authors.forename: Keith
authors.initials: K
authors.lastname: Joseph
authors.forename: Rocio
authors.initials: R
authors.lastname: Hurtado
authors.forename: Felix
authors.initials: F
authors.lastname: Alcantara
authors.forename: Jaime
authors.initials: J
authors.lastname: Bayona
authors.forename: Cesar
authors.initials: C
authors.lastname: Bonilla
authors.forename: Paul
authors.initials: P
authors.lastname: Farmer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Furin
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents