Vigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles.
The absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8(+)-T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.
Jaye
Assan
A
Medical Research Council Laboratories, Banjul, The Gambia. ajaye@mrc.gm
Herberts
Carla A
CA
Jallow
Sabelle
S
Atabani
Sowsan
S
Klein
Michel R
MR
Hoogerhout
Peter
P
Kidd
Michael
M
van Els
Cécile A C M
CA
Whittle
Hilton C
HC
D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D015234:HLA-A Antigens / Q000378:metabolism*; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism*; D008457:Measles / Q000276:immunology; D008459:Measles virus / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D015234:HLA-A Antigens; D016056:Immunodominant Epitopes; D010455:Peptides; D017361:Viral Nonstructural Proteins; D007371:Interferon-gamma