Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats.
Cyclooxygenase-2 (COX-2) inhibitors have been shown to block memory retention in rodents following Morris water maze training and in chicks following a passive avoidance task. However, the role of COX-2 in acquisition has not been analyzed. We show that pre-training intrahippocampal infusion of a COX-2 specific inhibitor (celecoxib) attenuated water maze acquisition. These findings, along with previously published reports, implicate COX-2 activity in both memory acquisition and retention.
Rall
Jason M
JM
Department of Neurobiology and Anatomy, Neurosurgery, Vivian L. Smith Center for Neurologic Research, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225, USA.
Mach
Sara A
SA
Dash
Pramod K
PK
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006624:Hippocampus; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000187:drug effects; D013037:Spatial Behavior / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D011720:Pyrazoles; D013449:Sulfonamides; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib