[Association study of heroin dependence and catechol-O-methyltransferase gene].
OBJECTIVE
To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene.


METHODS
Genotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls.


RESULTS
No differences in genotype and allele frequencies of 108 val/met polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=1.67, P=0.43; allele-wise: chi-square=1.23, P=0.27). No differences in genotype and allele frequencies of 900 Ins C/Del C polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=3.73, P=0.16; allele-wise: chi-square=0.76, P=0.38).


CONCLUSIONS
The results suggested that neither 108 val/met polymorphism nor 900 Ins C/Del C polymorphism of COMT gene was associated with heroin dependence.
Cao
Liping
L
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P.R. China. caoliping@hotmail.com
Li
Tao
T
Liu
Xiehe
X
D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006556:Heroin Dependence / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
D004247:DNA; D002394:Catechol O-Methyltransferase