title: [Possibility of persistent replication of HBV in patients with serological evidence of virus elimination].
abstract: Hepatitis B virus infection remains a major epidemiological health problem worldwide, due to the high prevalence (350 mln new cases per year) and clinical consequences of this infection including chronic hepatitis, liver cirrhosis and primary liver cancer. Two cases of patients with clinical symptoms of chronic hepatitis B without traditional serological markers, pointing to active hepatitis B viral replication, were presented. The diagnosis has been confirmed by molecular methods, typical histopathology of liver biopsy specimens, and biochemical improvement after lamivudine treatment.
authors.affiliation: Katedra i Klinika Chorób Zakaznych AM, Wrocławiu.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Simon
authors.forename: Paweł
authors.initials: P
authors.lastname: Piszko
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rotter
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zalewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gładysz
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle / Q000379:methods; D005260:Female; D006515:Hepatitis B virus / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008099:Liver / Q000737:chemistry* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D019259:Lamivudine