Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.
The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.
Guo-Ross
Shirley X
SX
Neurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA.
Jones
Katherine H
KH
Shetty
Ashok K
AK
Wilson
Wilkie A
WA
Swartzwelder
H Scott
HS
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002794:Choline / Q000494:pharmacology*; D002796:Choline Deficiency / Q000196:embryology / Q000378:metabolism; D004032:Diet; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D018691:Excitatory Amino Acid Antagonists; D018697:Nootropic Agents; D016291:Dizocilpine Maleate; D002794:Choline