The immunological consequences of photodynamic treatment of cancer, a literature review.
In this review we discuss the effect of photodynamic treatment (PDT) of solid tumors on the immune response. The effect on both the innate and adapted immune response is discussed. We have summarized the evidence that PDT causes or enhances an anti-tumor response. PDT is a local treatment in which the treated tumor remains in situ while the immune system is only locally affected and still functional in contrast with e.g. after systemic chemotherapy. We conclude that PDT of cancer is a way of in situ vaccination to induce a systemic antitumor response. In general, immune cells are found in the tumor stroma, separated from tumor cells by extracellular matrix and basal membrane-like structures. We hypothesize that PDT destroys the structure of a tumor, thereby enabling direct interaction between immune cells and tumor cells resulting in the systemic anti-tumor immune response.
van Duijnhoven
Frederieke H
FH
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Aalbers
Remco I J M
RI
Rovers
Jeroen P
JP
Terpstra
Onno T
OT
Kuppen
Peter J K
PJ
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007167:Immunotherapy; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D010778:Photochemotherapy