[Effects of flavonoids from semen Cuscutae on changes of beta-EP in hypothalamuses and FSH and LH in anterior pituitaries in female rats exposed to psychologic stress].
OBJECTIVE
To study the mechanism of flavonoids from Semen Cuscutae (FSC) improving the ovarian endocrine functions.


METHODS
(1) FSC were obtained from the semen of Cuscuta chinensis through solvent extraction and polyamide columnar chromatography. (2) Sound, light and electricity were combined into a stressful stimulas to induce psychologic stress in female rats. (3) To observe the effects of FSC on the changes of beta-EP in hypothalamuses, FSH and LH in anterior pituitaries and the changes in pituitary morphology in female rats exposed to psychologic stress.


RESULTS
FSC decreased the content of beta-EP in hypothalamuses, and increased the numbers of basophilic cell and content of LH in anterior pituitaries, didn't change content of FSH in anterior pituitaries in female rats exposed to psychologic stress.


CONCLUSIONS
FSC decreases the contents of beta-EP in hypothalamuses and increases contents of LH in anterior pituitaries in female rats exposed to psychologic stress, which may be one of the mechanism of FSC improving hypothalamus-pituitary-ovary axis.
Wang
Jianhong
J
Jiangxi College of TCM, Nanchang, Jiangxi 330006, China.
Wang
Minzhang
M
Ou
Yangdong
Y
Wu
Qinghua
Q
D000818:Animals; D034182:Cuscuta / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013315:Stress, Psychological / Q000378:metabolism; D001615:beta-Endorphin / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D001615:beta-Endorphin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone