title: Acute necrotizing encephalopathy: diffusion MR imaging and localized proton MR spectroscopic findings in two infants.
abstract: In this report, we describe the findings of diffusion MR imaging and proton MR spectroscopy in two infants with acute necrotizing encephalopathy in which there was characteristic symmetrical involvement of the thalami. Diffusion MR images of the lesions showed that the observed apparent diffusion coefficient (ADC) decrease was more prominent in the first patient, who had more severe brain damage and a poorer clinical outcome, than in the second. Proton MR spectroscopy detected an increase in the glutamate/glutamine complex and mobile lipids in the first case but only a small increase of lactate in the second. Diffusion MR imaging and proton MR spectroscopy may provide useful information not only for diagnosis but also for estimating the severity and clinical outcome of acute necrotizing encephalopathy.
authors.affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Goo
authors.forename: Choong-Gon
authors.initials: CG
authors.lastname: Choi
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Yoon
authors.forename: Tae-Sung
authors.initials: TS
authors.lastname: Ko
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007223:Infant; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000175:diagnosis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male