Signalling mechanisms in progesterone-neurotransmitter interactions.
The current and expanded view of transcriptional regulation by the steroid/thyroid superfamily of nuclear transcription factors integrates not only the hormone-dependent but also the hormone-independent cellular signaling mechanisms in physiology and reproduction. This effort has vastly been aided by the identification of steroid hormone receptors as transcriptional mediators of a variety of ligands, whose transcriptional response is dependent upon cross-talk with distinct signal transduction pathways, their recruitment of coregulators, alteration of chromatin structure and identification of specific interactive motifs within the receptors themselves. This review will provide a framework for the current concepts in the field of steroid hormone action as exemplified by our studies on progesterone receptor in female sexual behavior.
Mani
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Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. smani@bcm.tmc.edu
D000818:Animals; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D018377:Neurotransmitter Agents; D011980:Receptors, Progesterone; D011374:Progesterone; D004298:Dopamine