IP-10, but not RANTES, is upregulated by leptin in monocytic cells.
We and others have previously shown that leptin has direct effects on the function of monocytes and macrophages. Since obesity is associated with an increased cardiovascular risk, as well as with markedly elevated circulating leptin levels, we examined whether leptin has any pro-inflammatory effects on the function of monocytes. Leptin strongly enhanced the expression and secretion of the interferon-gamma-inducible protein (IP-10) in a human monocytic cell line, as well as in peripheral blood mononuclear cells. In contrast, no significant effect on other inflammatory proteins was observed, such as metalloproteinases and other chemokines. In summary, we have demonstrated that leptin selectively induces the expression and secretion of IP-10 in human monocytic cells, potentially contributing to the vascular complications associated with hyperleptinemic obesity in humans.
Meier
Christoph A
CA
Endocrine Unit, Division of Endocrinology, Diabetes and Nutrition, Department of Internal Medicine, University Hospital Geneva, 24, rue Micheli-du-Crest, CH-1211 14 Geneva, Switzerland. christoph.Meier@medecine.unige.ch
Chicheportiche
Rachel
R
Dreyer
Magali
M
Dayer
Jean-Michel
JM
D002319:Cardiovascular System / Q000378:metabolism; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000096:biosynthesis*; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000096:biosynthesis*; D016207:Cytokines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D015854:Up-Regulation
D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D016207:Cytokines; D020738:Leptin; D008070:Lipopolysaccharides; D045726:Metalloproteases