Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides.
Four antimicrobial peptides, protegrin-1, RTD-1, cryptdin-4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In general, protegrin-1 was found to have the strongest anti-chlamydial activity. Overall, of the three serovars tested, L2 was the most susceptible while MoPn was the most resistant to these peptides.
Chong-Cerrillo
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C
Department of Pathology, Medical Sciences, Room D440, University of California, Irvine, CA 92697-4800, USA.
Selsted
M E
ME
Peterson
E M
EM
de la Maza
L M
LM
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D023082:Defensins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D006098:Granulocytes; D006801:Humans; D051379:Mice; D010455:Peptides / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology; D011506:Proteins / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits; D023084:alpha-Defensins
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C429483:DEFA1A3 protein, human; D023082:Defensins; D010455:Peptides; D010456:Peptides, Cyclic; D011506:Proteins; D023084:alpha-Defensins; C401847:cryptdin 4, mouse; C094880:protegrin-1; C073143:indolicidin