Synthesis and biological properties of S-adamantylated heterocyclic compounds.
A series of new S-adamantylated compounds were prepared by adamanlyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-alpha in genetically modified mouse melanoma cells is presented.
Górska
Agata
A
Institute of Chemistry, Agricultural University, 159C Nowoursynowska Str., 02-787 Warsaw, Poland.
Switaj
Tomasz
T
Młynarczukh
Izabela
I
Lasek
Witold
W
Kazimierczuk
Zygmunt
Z
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D014409:Tumor Necrosis Factor-alpha; D000218:Adamantane