[Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice].
OBJECTIVE
To observe the effect of the recombinant human granulocyto colony-stimulating factor (rhG-CSF) on radiation-induced neutropenia models of mice.


METHODS
rhG-CSF in 2 different doses (10 micrograms.kg-1.d-1 and 30 micrograms.kg-1.d-1) was injected respectively to radiation-induced neutropenia models of mice. The effect of rhG-CSF on the weight of the spleen, CFU-S, leukocyte counts, neutrophil counts, and CFU-GM of the marrow cell culture was observed.


RESULTS
Both 30 and 10 micrograms.kg-1.d-1 of rhG-CSF increased CFU-GM of the marrow cell culture and the peripheral leukocyte and neutrophil, showing a significant difference compared with the NS control group (P < 0.05).


CONCLUSIONS
rhG-CSF has a significant therapeutic effect on radiation-induced agranulocytosis models of mice.
Zhu
Hong
H
Department of Radiotherapy, Xiangya Hospital, Central South University, Changsha 410008, China.
Lai
Fu-ying
FY
Sun
Li
L
D000380:Agranulocytosis / Q000209:etiology / Q000628:therapy*; D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor