title: Pseudomonas corneal ulcer related to overnight orthokeratology.
abstract: OBJECTIVE
  To report two cases of Pseudomonas aeruginosa corneal ulcers as a complication of overnight orthokeratology lens wear.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  Two 11-year-old girls with acute central corneal ulcers were referred to our hospital. In both cases, the ulcers were about 2 mm in diameter, located centrally, contained dense cellular infiltration, and discharged purulent material. Intensive topical ceftazidime was applied to treat the ulcers. Cultures of the scraped corneal tissues and the contact lens storage solutions in both cases grew P. aeruginosa, which was sensitive to the antibiotic. The presenting best-corrected visual acuity was hand motion at 20 cm in one patient and 6/20 in the other. Both patients had received several months of overnight orthokeratology treatment with rigid gas permeable contact lenses to correct myopia (-4.25 D and -4.75 D in the two affected eyes). The final best-corrected visual acuity was 6/60 in one patient and 6/7.5 in the other.
  
  
  CONCLUSIONS
  Overnight orthokeratology contact lens wear carries a potential risk of corneal ulcer and may cause significant visual impairment in children.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. lilau@ms41.hinet.net
authors.forename: Ling-Ing
authors.initials: LI
authors.lastname: Lau
authors.forename: Chih-Chiau
authors.initials: CC
authors.lastname: Wu
authors.forename: Shui-Mei
authors.initials: SM
authors.lastname: Lee
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Hsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D002648:Child; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000382:microbiology; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D009216:Myopia / Q000628:therapy; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime