The TCR ADAPts to integrin-mediated cell adhesion.
Adapter proteins regulate leukocyte signal transduction through recruitment of effector molecules to multiprotein complexes. Recent studies in Adhesion and Degranulation promoting Adapter Protein (ADAP)-deficient mice have established that the cytoplasmic phosphoprotein ADAP is required for optimal, mature T-cell proliferation. Furthermore, ADAP plays a key role in T-cell antigen receptor (TCR)-mediated 'inside out' signaling leading to integrin activation and to enhanced cellular adhesion to integrin ligands. ADAP associates physically with molecules known to play roles in the regulation of TCR-stimulated actin polymerization. These associations support the hypothesis that ADAP functions in actin cytoskeletal reorganization leading to cellular adhesion and activation.
Peterson
Erik J
EJ
Division of Rheumatology, Department of Medicine and the Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. peter899@umn.edu
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002448:Cell Adhesion; D003599:Cytoskeleton / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C106957:FYB1 protein, human; C491468:Fyb protein, mouse; D016023:Integrins; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases