Defenses against peroxynitrite: selenocompounds and flavonoids.
The inflammatory mediator peroxynitrite, when generated in excess, may damage cells by oxidizing and nitrating cellular components. Defense against this reactive species may be at the level of prevention of the formation of peroxynitrite, at the level of interception, or at the level of repair of damage caused by peroxynitrite. Several selenocompounds serve this purpose and include selenoproteins such as glutathione peroxidase (GPx), selenoprotein P and thioredoxin reductase, or low-molecular-weight substances such as ebselen. Further, flavonoids, such as (-)-epicatechin, which occurs in green tea or cocoa as monomer or in the form of oligomers, can contribute to cellular defense against peroxynitrite.
Klotz
Lars-Oliver
LO
Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Postfach 101007, D-40001, Düsseldorf, Germany.
Sies
Helmut
H
D005419:Flavonoids / Q000378:metabolism / Q000494:pharmacology*; D030421:Peroxynitrous Acid / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D051149:Selenoprotein P; D051140:Selenoproteins; D015398:Signal Transduction / Q000187:drug effects*
D005419:Flavonoids; D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D030421:Peroxynitrous Acid