title: Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli.
abstract: The response regulator EvgA controls expression of multiple genes conferring antibiotic resistance in Escherichia coli (K. Nishino and A. Yamaguchi, J. Bacteriol. 184:2319-2323, 2002). To understand the whole picture of EvgA regulation, DNA macroarray analysis of the effect of EvgA overproduction was performed. EvgA activated genes related to acid resistance, osmotic adaptation, and drug resistance.
authors.affiliation: Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki-shi, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Nishino
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Inazumi
authors.forename: Akihito
authors.initials: A
authors.lastname: Yamaguchi
mesh_terms: D000143:Acids; D000222:Adaptation, Physiological; D001426:Bacterial Proteins / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D020411:Oligonucleotide Array Sequence Analysis; D009994:Osmolar Concentration; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000143:Acids; D001426:Bacterial Proteins; C065601:BvgA protein, Bacteria; D029968:Escherichia coli Proteins; C489314:EvgA protein, E coli; D014157:Transcription Factors