title: Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area.
abstract: Serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels were investigated in 31 children living in an endemic goiter area and 33 healthy subjects living in an nonendemic area. Serum IGF-I and IGFBP-3 levels of iodine- and selenium-deficient children were found to be lower than those of control subjects (p<0.001). There was a positive correlation between the IGF-I with chronological age and body mass index. There was also positive correlation between the IGF-I and IGFBP-3. No significant difference was found between the goitrous and nongoitrous children. These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter.
authors.affiliation: Department of Pediatrics, Selcuk University Medical Faculty, Konya, Turkey.
authors.forename: Kursad
authors.initials: K
authors.lastname: Aydin
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kendirci
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
mesh_terms: D002648:Child; D002851:Chromatography, High Pressure Liquid; D003677:Deficiency Diseases / Q000097:blood / Q000150:complications; D005260:Female; D006043:Goiter, Endemic / Q000097:blood* / Q000150:complications* / Q000473:pathology; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D008297:Male; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D013961:Thyroid Gland / Q000473:pathology; D014421:Turkey
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007455:Iodine; D012643:Selenium