title: Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems.
abstract: [reaction: see text] Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.
authors.affiliation: Departamento de Química Orgánica II, Facultad de Ciencias, Universidad del País Vasco, Apdo. 644, 48080 Bilbao, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Ruiz
authors.forename: Nuria
authors.initials: N
authors.lastname: Sotomayor
authors.forename: Esther
authors.initials: E
authors.lastname: Lete