Isolation of two phenylethanoid glycosides from Eremophila gilesii.
The leaves of Eremophila gilesii have been used traditionally to treat colds, headaches, sores, and chest pains. Our previous screening of Australian native plants showed that the methanol extract of the aerial parts of E. gilesii demonstrated notable inhibition of ADP-induced human platelet aggregation and serotonin release. Subsequent fractionation on the methanol extract led to the isolation of two phenylethanoid glycosides, verbascoside (1) and poliumoside (2). This is the first study reporting the presence of phenylethanoid glycosides in E. gilesii.
Grice
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Centre for Biomolecular Science and Drug Discovery, Gold Coast Campus, Griffith University, PMB 50, GCMC Gold Coast 9726, Qld, Australia. d.grice@mailbox.gu.edu.au
Garhnam
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B
Pierens
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Rogers
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K
Tindal
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Griffiths
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D001315:Australia; D005960:Glucosides / Q000302:isolation & purification* / Q000493:pharmacokinetics; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010636:Phenols / Q000302:isolation & purification* / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D059808:Polyphenols
D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; C058956:acteoside; D059808:Polyphenols