title: TMC-264, a novel antiallergic heptaketide produced by the fungus Phoma sp. TC 1674.
abstract: [structure: see text] TMC-264 (1), a novel tricyclic heptaketide with a unique chloro-1H-dibenzo[b,d]pyran-4,6-dione skeleton, was discovered from the fungus Phoma sp. TC 1674. The structure was elucidated on the basis of NMR analyses of normal abundance and biosynthetically (13)C-enriched TMC-264. TMC-264 showed potent inhibitory activity against tyrosine phosphorylation of STAT6.
authors.affiliation: Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-50 Kawagishi-2-chome, Toda-shi, Saitama 335-8505, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sakurai
authors.forename: Maki
authors.initials: M
authors.lastname: Nishio
authors.forename: Kouzou
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Okuda
authors.forename: Kimio
authors.initials: K
authors.lastname: Kawano
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohnuki
mesh_terms: D005658:Fungi / Q000737:chemistry* / Q000145:classification; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010766:Phosphorylation / Q000187:drug effects; D019000:Phosphotyrosine / Q000378:metabolism; D050800:STAT6 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D050800:STAT6 Transcription Factor; C476504:TMC-264; D015534:Trans-Activators; D019000:Phosphotyrosine