G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy.
A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.
Dishy
Victor
V
Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville Tennessee 37232-6602, USA.
Gupta
Simi
S
Landau
Ruth
R
Xie
Hong-Guang
HG
Kim
Richard B
RB
Smiley
Richard M
RM
Byrne
Daniel W
DW
Wood
Alastair J J
AJ
Stein
C Michael
CM
D000328:Adult; D001724:Birth Weight; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy / Q000235:genetics / Q000502:physiology*; D015430:Weight Gain / Q000235:genetics*
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins