Functional consequences of histone modifications.
Covalent modifications of the histone proteins have well-known roles in gene expression. Experiments reported during the past year have extended this paradigm to include roles for histone acetylation and phosphorylation in DNA double-strand break repair. In addition, new results now provide a definitive example of an acetylation histone code, whereas others reveal the workings of a charge patch mechanism. Finally, exciting research has identified new modifications, complex modification cascades, and functional links to DNA methylation and RNA interference pathways.
Iizuka
Masayoshi
M
Department of Microbiology, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA.
Smith
M Mitchell
MM
D000107:Acetylation; D000123:Acetyltransferases / Q000502:physiology; D000818:Animals; D006657:Histones / Q000502:physiology*; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000502:physiology; D010766:Phosphorylation; D010770:Phosphotransferases / Q000502:physiology; D012313:RNA / Q000502:physiology; D012568:Schizosaccharomyces / Q000502:physiology
D006657:Histones; D012313:RNA; D008780:Methyltransferases; D000123:Acetyltransferases; D010770:Phosphotransferases