title: [Effects of ultraviolet irradiation on structural and functional condition of T- and B-lymphocytes of human blood].
abstract: The influence of ultraviolet (UV) radiation on structural and functional condition of membranes T- and B-lymphocytes of human blood is investigated. It is shown, that intergral flow of UV-light (240-390 nm) in doses 151-1359 J/m2 leads to the increase of the expression of some HLA-antigen (DR1, DR2, DR5, DR7) and Fc-receptors on membranes of B-lymphocytes. The level of HLA-antigen was increased by 20-500% from the initial state after exposure to different doses. The growth of the expression of Fc-receprots was registered in 80% of the donors in the range from 20 up to 540%. The minimum dose of UV-light (151 J/m2) caused the maximum effect. The reduction of the level of Fc-receptors by 10-90% relatively to the native condition was registered for T-cells in 80% of the donors. Groups of the donors were revealed, T-lymphocytes of which differed by the sensitivity to UV-radiation. The effect of "strengthening--weakening", resulting to the reduction of the initially high parameters and to increase in the initially low ones was found.
authors.affiliation: Faculty of Biology and Soil Science, Voronezh State University, Voronezh, 394006 Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Artiukhov
authors.forename: O V
authors.initials: OV
authors.lastname: Putintseva
authors.forename: E V
authors.initials: EV
authors.lastname: Dmitriev
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D001782:Blood Donors; D003627:Data Interpretation, Statistical; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D006684:HLA-DR Antigens; D011961:Receptors, Fc