Isolation and characterization of two new antifungal antibiotics from a basidiomycete.
Two novel antibiotics, Sch 484129 (1) and Sch 484130 (2), were isolated from the fermentation broth of a fungal culture, which was identified as a Basidiomycete. The new antibiotics were obtained by ethyl acetate extraction followed by reversed phase HPLC purification. Structure elucidation of 1 and 2 was accomplished by spectroscopic data analyses. Derivatizations of the major component 1 were performed in order to provide definitive structural information. Both components were identified as glycolipids and displayed antifungal activity against Saccharomyces and Aspergillus strains.
Chu
Min
M
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey, USA. min.chu@spcorp.com
Mierzwa
Ronald
R
Xu
Ling
L
He
Ling
L
Langsdorf
Erik
E
Beyazova
Martha
M
Terracciano
Joseph
J
Patel
Mahesh
M
Chan
Tze-Ming
TM
Gullo
Vincent
V
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012440:Saccharomyces / Q000187:drug effects
D000935:Antifungal Agents; D006017:Glycolipids; D009005:Monosaccharides; C472759:Sch 484129; C472760:Sch 484130