title: Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients.
abstract: Impaired fibrinolysis is a common finding in obese humans. This condition is now considered as an established risk factor for thromboembolic complications. Furthermore, obesity is characterized by a specific pattern of circulating concentrations of fat-cell products interleukin-6 (IL-6), leptin, and adiponectin. The aim of our study was to investigate the relationship between these proteins and selected variables of the fibrinolytic system in 74 mildly hypertensive, overweight subjects. Circulating IL-6 and leptin levels showed a positive association with BMI (r = 0.24, p = 0.04 and r = 0.70, p < 0.0001), whereas adiponectin was not correlated to BMI. Interestingly, IL-6 was also positively associated with t-PA/PAI-1 complexes after adjustment for BMI and other anthropometric variables. Leptin was positively correlated with PAI-1 activity and antigen (r = 0.32, p = 0.006 and r = 0.37, p < 0.001, respectively) and negatively with t-PA activity (r = -0.27, p = 0.03). However, these associations lost significance after correction for BMI or HOMA, an insulin sensitivity index. In contrast, adiponectin levels were independently and negatively correlated with PAI-1 antigen (r = -0.26, p = 0.04, after correction for BMI). In conclusion, our study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans.
authors.affiliation: German Diabetes Research Institute at the Heinrich-Heine-University, Düsseldorf, Germany. skurk@ddfi.uni-duesselforf.de
authors.forename: T
authors.initials: T
authors.lastname: Skurk
authors.forename: V
authors.initials: V
authors.lastname: van Harmelen
authors.forename: Y-M
authors.initials: YM
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Wirth
authors.forename: H
authors.initials: H
authors.lastname: Hauner
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011506:Proteins / Q000502:physiology*; D013223:Statistics as Topic
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D020738:Leptin; D011506:Proteins