title: Life extension properties of superoxide dismutase mimics arise from "calorie restriction".
abstract: Manganese-salen superoxide dismutase mimics interfere with the mitochondrial electron transport chain by acting as antimetabolites and thus effect "calorie restriction," leading to extended lifespan.
authors.affiliation: School of Pharmacy and Biomolecular Science, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom. d.p.naughton@bton.ac.uk
authors.forename: Declan Patrick
authors.initials: DP
authors.lastname: Naughton
authors.forename: Anna E
authors.initials: AE
authors.lastname: Fisher
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000737:chemistry / Q000494:pharmacology*; D031204:Caloric Restriction; D004579:Electron Transport; D005029:Ethylenediamines / Q000737:chemistry / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D018716:Molecular Mimicry; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000737:chemistry*
chemical_list: D000963:Antimetabolites; D005029:Ethylenediamines; D009942:Organometallic Compounds; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D013482:Superoxide Dismutase