Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells.
Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infection/vaccination determine the extent and nature of both effector and memory cell development.
Swain
Susan L
SL
Trudeau Institute, PO Box 59, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007156:Immunologic Memory; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*