Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells--an immuno electron microscopic study.
Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known: its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.
Seftalioglu
Aysel
A
Department of Histology & Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Karakus
Sema
S
Dundar
Semra
S
Can
Belgin
B
Erdemli
Esra
E
Irmak
M Kemal
MK
Oztas
Emin
E
Korkmaz
Cem
C
Yazar
Fatih
F
Cavusoglu
Ilkin
I
D000328:Adult; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism*; D053668:Syndecan-1; D053667:Syndecans
D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans