title: Two multichannel integrated circuits for neural recording and signal processing.
abstract: We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 microV(rms). Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 microV(rms). Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. io@duke.edu
authors.forename: Iyad
authors.initials: I
authors.lastname: Obeid
authors.forename: James C
authors.initials: JC
authors.lastname: Morizio
authors.forename: Karen A
authors.initials: KA
authors.lastname: Moxon
authors.forename: Miguel A L
authors.initials: MA
authors.lastname: Nicolelis
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Wolf
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D000818:Animals; D016477:Artifacts; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D000882:Haplorhini; D008904:Miniaturization; D009474:Neurons / Q000502:physiology; D010865:Pilot Projects; D011786:Quality Control; D051381:Rats; D012666:Semiconductors; D013003:Somatosensory Cortex / Q000502:physiology*