Discovering nature's diverse pathways to vitamin B12: a 35-year odyssey.
The chronology of the discoveries along the pathway of vitamin B(12) biosynthesis is reviewed from a personal perspective, including discussion of the most recent finding that two pathways to B(12) exist-one aerobic and one anaerobic-which differ mainly in the ring contraction mechanisms that convert porphyrin to corrin.
Scott
A Ian
AI
Center for Biological NMR, Chemistry Department, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA. aiscott@tamu.edu
D000332:Aerobiosis; D000693:Anaerobiosis; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D045728:Corrinoids; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011166:Porphyrins / Q000378:metabolism; D014805:Vitamin B 12 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D045728:Corrinoids; D011166:Porphyrins; D014805:Vitamin B 12