title: Association of histologic chorioamnionitis, increased levels of cord blood cytokines, and intracerebral hemorrhage in preterm neonates.
abstract: The objective of this study was to investigate in a prospective study whether histological chorioamnionitis (ChA) is a risk factor predisposing for intracerebral hemorrhage (ICH), and whether ICH is associated with a systemic fetal inflammation in preterm neonates with a gestational age <32 weeks. 106 neonates were studied; 20 (18.9%) suffered from ICH. ChA occurred significantly more often in neonates with ICH compared to neonates without ICH (70.0 vs. 36.0%, p = 0.006). Neonates with ICH had significantly higher median levels of proinflammatory cytokines (IL-1beta, IL-6 and IL-8) compared to neonates without ICH (p < 0.001 for all comparisons). We conclude that the development of ICH in preterm infants is associated with both ChA and high levels of proinflammatory cytokines at birth.
authors.affiliation: Department of Neonatology, Children's Hospital, Hospitals of the City of Cologne, Germany.
authors.forename: M K
authors.initials: MK
authors.lastname: Tauscher
authors.forename: D
authors.initials: D
authors.lastname: Berg
authors.forename: M
authors.initials: M
authors.lastname: Brockmann
authors.forename: S
authors.initials: S
authors.lastname: Seidenspinner
authors.forename: C P
authors.initials: CP
authors.lastname: Speer
authors.forename: P
authors.initials: P
authors.lastname: Groneck
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications*; D002821:Chorioamnionitis / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators / Q000097:blood*; D011247:Pregnancy
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators