Radiofrequency ablation extends the scope of surgery in colorectal liver metastases.
OBJECTIVE
To assess outcome in patients treated by a multidisciplinary team, with a combination of liver resection and RF ablation.


METHODS
Sixteen unselected patients (f=9; m=7) with colorectal liver metastases who were not suitable for surgery alone, were treated as follows: six had RF ablation at open laparotomy, three patients had synchronous ablation and resection while seven patients had RF ablation after liver resection. Standard liver resection techniques were used. RF was performed using internally cooled, single or cluster electrodes with a high power (200 W) generator. All patients were followed with regular contrast enhanced CT and survival noted.


RESULTS
A total of 27 tumours with diameters 1.2-10 cm were treated. Two minor complications were recorded. 2/6 (33%) who had intraoperative RF had incomplete ablation due to large tumour size (6 and 10 cm respectively). Further RF ablation sessions were carried out successfully. 11/16 (69%) are alive at 2 years of whom 7 (44%) have no evidence of residual or recurrent liver disease.


CONCLUSIONS
In our study, RF ablation extends the therapeutic envelope, is an effective local treatment of liver metastases and improves life expectancy.
Oshowo
A
A
Department of Surgery, University College, London.
Gillams
A R
AR
Lees
W R
WR
Taylor
I
I
D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome