Nitric oxide, inducible nitric oxide synthase and inflammation in veterinary medicine.
Inflammation is a process consisting of a complex of cytological and chemical reactions which occur in and around affected blood vessels and adjacent tissues in response to an injury caused by a physical, chemical or biological insult. Much work has been performed in the past several years investigating inducible nitric oxide synthase (NOS, EC 1.14.13.39) and nitric oxide in inflammation. This has resulted in a rapid increase in knowledge about iNOS and nitric oxide. Nitric oxide formation from inducible NOS is regulated by numerous inflammatory mediators, often with contradictory effects, depending upon the type and duration of the inflammatory insult. Equine medicine appears to have benefited the most from the increased interest in this small, inflammatory mediator. Most of the information on nitric oxide in traditional veterinary species has been produced using models or naturally occurring inflammatory diseases of this species.
Hunter
Robert P
RP
Department of Anatomy and Physiology, Kansas State University, College of Veterinary Medicine, 129 Coles Hall, Manhattan, Kansas 66506-5802, USA. rhunter@vet.k-state.edu
D000818:Animals; D001120:Arginine / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D015232:Dinoprostone / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D009569:Nitric Oxide / Q000276:immunology / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II
D016207:Cytokines; D009569:Nitric Oxide; D006632:Histamine; D003577:Cytochrome P-450 Enzyme System; D001120:Arginine; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D015232:Dinoprostone