title: Arsenic methylation and skin cancer risk in southwestern Taiwan.
abstract: Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability. We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (< or = 5), CAE > 15 mg/L-year was associated with an increased risk of skin cancer (OR, 7.48; 95% CI, 1.65-33.99) compared to a CAE < or = 2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95% CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.
authors.affiliation: Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
authors.forename: Yen-Ching
authors.initials: YC
authors.lastname: Chen
authors.forename: Yu-Liang Leon
authors.initials: YL
authors.lastname: Guo
authors.forename: Huey-Jen Jenny
authors.initials: HJ
authors.lastname: Su
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Hsueh
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Smith
authors.forename: Louise M
authors.initials: LM
authors.lastname: Ryan
authors.forename: Meei-Shyuan
authors.initials: MS
authors.lastname: Lee
authors.forename: Sheau-Chiou
authors.initials: SC
authors.lastname: Chao
authors.forename: Julia Yu-Yun
authors.initials: JY
authors.lastname: Lee
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001151:Arsenic / Q000378:metabolism*; D016022:Case-Control Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008745:Methylation; D008875:Middle Aged; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000453:epidemiology*; D012907:Smoking; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001151:Arsenic