title: A specific chromosome aberration in a keratoacanthoma.
abstract: Specific cytogenetic changes observed in various tumors indicate that a chromosomal event may play a key role in malignant transformation. We present a patient with keratoacanthoma with a sole chromosome abnormality. The karyotype found in short-term culture was 46,XY,t(2;8)(p13;p23); a normal male chromosome complement was also found. The finding of t(2;8) as a sole anomaly suggests that this aberration is a primary change in keratoacanthoma and might be important in the pathobiology of this tumor.
authors.affiliation: Department of Anatomy, Institute for Medical Genetics, Keimyung University School of Medicine, Dongsan-dong, Jung-gu, Daegu 700-712, South Korea. dkkim@dsmc.or.kr
authors.forename: Dae-Kwang
authors.initials: DK
authors.lastname: Kim
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyeung-Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Han
authors.forename: Dae-Gu
authors.initials: DG
authors.lastname: Shon
mesh_terms: D000328:Adult; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D005385:Fingers / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D007636:Keratoacanthoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured