Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
van der Walt
J M
JM
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.
Martin
E R
ER
Scott
W K
WK
Zhang
F
F
Nance
M A
MA
Watts
R L
RL
Hubble
J P
JP
Haines
J L
JL
Koller
W C
WC
Lyons
K
K
Pahwa
R
R
Stern
M B
MB
Colcher
A
A
Hiner
B C
BC
Jankovic
J
J
Ondo
W G
WG
Allen
F H
FH
Goetz
C G
CG
Small
G W
GW
Mastaglia
F
F
Roses
A D
AD
Stajich
J M
JM
Booze
M W
MW
Fujiwara
K
K
Gibson
R A
RA
Middleton
L T
LT
Scott
B L
BL
Pericak-Vance
M A
MA
Vance
J M
JM
D000368:Aged; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018570:Risk Assessment
D007527:Isoenzymes; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1; C478900:NAT2 protein, human