title: Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats.
abstract: We recently reported the effects of repeated administration of the monoisoamyl ester of dimercaptosuccinic acid (MiADMSA) on a few selected biochemical variables indicative of haematopoietic, liver, kidney and brain toxicity, oxidative stress and essential metal status in male rats. The present investigation studies similar changes in female rats to fi nd out if the changes are independent of gender. The results suggest significant and pronounced toxic effects of MiADMSA on haem biosynthesis, liver and kidneys in female rats exposed to higher doses of orally (p.o.) or intraperitoneally (i.p.) administered MiADMSA, compared with the effects in male rats. No effects on brain tissues were seen. A pronounced depletion of copper was noted in the blood and liver of MiADMSA administered rats, irrespective of route of exposure. It can be concluded that the administration of MiADMSA in female rats is confounded with side-effects and may require caution during its use and further exploration.
authors.affiliation: Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior-474002, India. sjsflora@hotmail.com
authors.forename: Swaran J S
authors.initials: SJ
authors.lastname: Flora
authors.forename: Ashish
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001921:Brain / Q000187:drug effects; D002614:Chelating Agents / Q000008:administration & dosage / Q000633:toxicity*; D003300:Copper / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D004113:Succimer / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D015032:Zinc / Q000032:analysis / Q000097:blood
chemical_list: D002614:Chelating Agents; D017392:Thiobarbituric Acid Reactive Substances; D003300:Copper; C091888:monoisoamyl-2,3-dimercaptosuccinate; D004113:Succimer; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010744:Phosphoric Monoester Hydrolases; D015032:Zinc