Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch.
In mammals and birds, sex differences in brain function and disease are thought to derive exclusively from sex differences in gonadal hormone secretions. For example, testosterone in male mammals acts during fetal and neonatal life to cause masculine neural development. However, male and female brain cells also differ in genetic sex; thus, sex chromosome genes acting within cells could contribute to sex differences in cell function. We analyzed the sexual phenotype of the brain of a rare gynandromorphic finch in which the right half of the brain was genetically male and the left half genetically female. The neural song circuit on the right had a more masculine phenotype than that on the left. Because both halves of the brain were exposed to a common gonadal hormone environment, the lateral differences indicate that the genetic sex of brain cells contributes to the process of sexual differentiation. Because both sides of the song circuit were more masculine than that of females, diffusible factors such as hormones of gonadal or neural origin also likely played a role in sexual differentiation.
Agate
Robert J
RJ
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA.
Grisham
William
W
Wade
Juli
J
Mann
Suzanne
S
Wingfield
John
J
Schanen
Carolyn
C
Palotie
Aarno
A
Arnold
Arthur P
AP
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology*; D004247:DNA / Q000235:genetics; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D017403:In Situ Hybridization; D008297:Male; D008959:Models, Neurological; D008969:Molecular Sequence Data; D010053:Ovary / Q000033:anatomy & histology; D010641:Phenotype; D012727:Sex Characteristics; D012730:Sex Chromosomes / Q000235:genetics; D012733:Sex Differentiation; D020308:Songbirds / Q000033:anatomy & histology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D013737:Testis / Q000033:anatomy & histology; D014828:Vocalization, Animal / Q000502:physiology
D012739:Gonadal Steroid Hormones; D004247:DNA