title: X-chromosome-linked immune-deficient mice have B-1b cells.
abstract: The B lymphocyte subsets of X-chromosome-linked immune-deficient (XID) mice were examined by flow cytometric analyses of spleen and peritoneal cells. As shown in prior studies, young adult XID mice had reduced representation of the CD5+ (B-1a) subset in their peritoneal cavity. However, the CD11b+ (B-1b) B-cell subset was present and exhibited the IgM(hi) CD45(lo) CD23- phenotype characteristic of most B-1 cells. Although present at a lower frequency than that found in their normal counterparts, B-1b cells were evident in CBA/N and (XD2J)F1 male mice. With increasing age, B-1b cell number increased and in the oldest XID mice were present as B-cell chronic lymphocytic leukaemia. These results show that XID mice do have B-1 cells, particularly the B-1b subset.
authors.affiliation: Department of Biology, Rider University, Lawrenceville, NJ 08648-3099, USA. riggs@rider.edu
authors.forename: J
authors.initials: J
authors.lastname: Riggs
authors.forename: K
authors.initials: K
authors.lastname: Howell
authors.forename: B
authors.initials: B
authors.lastname: Matechin
authors.forename: R
authors.initials: R
authors.lastname: Matlack
authors.forename: A
authors.initials: A
authors.lastname: Pennello
authors.forename: R
authors.initials: R
authors.lastname: Chiasson
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D040181:Genetic Diseases, X-Linked / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010529:Peritoneal Cavity / Q000166:cytology; D013154:Spleen / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M