title: Platelet physiology: in cold blood.
abstract: One of the impediments precluding long-term storage of platelets for blood transfusion is that refrigerated platelets are rapidly cleared from the circulation upon transfusion. New evidence suggests that this clearance is mediated in the liver by the Mac-1 integrin on Kupffer cells recognizing clustered GPIb receptor on platelets, leading to platelet phagocytosis.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Andrews
authors.forename: Michael C
authors.initials: MC
authors.lastname: Berndt
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D001803:Blood Transfusion; D006801:Humans; D007728:Kupffer Cells / Q000502:physiology; D016177:Macrophage-1 Antigen / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology; D010973:Platelet Adhesiveness / Q000502:physiology*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins; D012034:Refrigeration; D013696:Temperature
chemical_list: D016177:Macrophage-1 Antigen; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; C032193:glycoprotein receptor GPIb-IX