title: Pathogenesis of endometriosis--current research.
abstract: Proliferative, secretory and menstrual endometrial cells of both the stroma and epithelium adhere to intact peritoneal mesothelium and mesothelial monolayers. Endometrial attachment to the mesothelium appears to occur rapidly (within 1 h) and transmesothelial invasion occurs between 1 and 18-24 h. These results demonstrate that the mesothelium is not a 'no-stick' surface and indicates that molecules present at the surface of the mesothelium are involved in the pathogenesis of the early endometriotic lesion. The inhibition of endometrial cell adherence to peritoneal mesothelium by hyaluronidase indicates that CD44-hyaluronan binding is at least one of the mechanisms involved in the pathogenesis of endometriosis. We believe that investigation of mesothelial cell adhesion molecules is central to understanding the pathogenesis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Witz
authors.forename: Karen T
authors.initials: KT
authors.lastname: Allsup
authors.forename: Iris A
authors.initials: IA
authors.lastname: Montoya-Rodriguez
authors.forename: Shelby L
authors.initials: SL
authors.lastname: Vaughan
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Centonze
authors.forename: Robert S
authors.initials: RS
authors.lastname: Schenken
mesh_terms: D002448:Cell Adhesion; D004715:Endometriosis / Q000209:etiology* / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology; D008598:Menstruation; D010537:Peritoneum / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology
chemical_list: D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase