The Comparison of Immunoregulatory Properties of Human Alpha2-Macroglobulin and Pregnancy-Associated Alpha2-Glycoprotein.
Human alpha2-macroglobulin (MG) and pregnancy-associated alpha2-glycoprotein (PAG) are able to suppress proliferation of non-fractionated mononuclear blood cells and T- and B-enriched populations in spontaneous and mitogen-stimulated cultures in vitro. Immunosuppressive properties of both proteins are more expressed in mitogen-stimulated cultures than in spontaneous ones, and in T population than in B one. PAG is a more powerful immunosuppressor, because its suppressive effect is more than ten-fold greater than corresponding effect of MG. Female peripheral blood mononuclear cells are more susceptible to immunoregulatory effect of alpha2-glycoprotein than male ones. This fact may confirm the known alpha2-glycoprotein role as an immunoregulator in pregnancy.
Maltseva
N. V.
NV
Central Research Laboratory, Postgraduate Training Physician Institute, Novokuznetsk, Russia.
Zorin
N. A.
NA