Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures.
The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 microM) inhibited 50 min OGD-, 20 microM N-methyl-D-aspartate (NMDA)-, and 50 microM kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl(2), and FeCl(2). These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.
Ha
Hyun Joo
HJ
Department of Veterinary Medicine, Cheju National University, South Korea.
Kwon
Yong Soo
YS
Park
Shin Mi
SM
Shin
Taekyun
T
Park
Jun Hong
JH
Kim
Hyoung Chun
HC
Kwon
Myung Sang
MS
Wie
Myung Bok
MB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015687:Cell Hypoxia / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity*; D005947:Glucose / Q000172:deficiency*; D007608:Kainic Acid / Q000633:toxicity; D051379:Mice; D008813:Mice, Inbred ICR; D016202:N-Methylaspartate / Q000633:toxicity; D009457:Neuroglia / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology*
D000975:Antioxidants; D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate; D011794:Quercetin; D005947:Glucose; D010100:Oxygen; D007608:Kainic Acid