Perception of bronchoconstriction in obstructive pulmonary diseases (disease-specific dyspnoea).
The perception of dyspnoea differs between subjects with obstructive pulmonary diseases, partly because the underlying mechanisms for bronchoconstriction are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine. The Borg score was assessed before and after each challenge. The perception score corresponding to a fall in the forced expiratory volume in 1 s (FEV(1)) by 20% (PS(20)) was calculated. The mean values of DeltaBorg/DeltaFEV(1) (the Borg score change divided by the change in FEV(1) as a percentage of the baseline FEV(1)) and PS(20) of subjects with bronchiectasis and chronic bronchitis were significantly lower than in subjects with asthma after histamine challenge. The ratio of non-perceivers was higher in bronchiectasis (25.5%) and in chronic bronchitis (32.3%) than in asthma (4.0%). When all subjects were considered, DeltaBorg/DeltaFEV(1) values were significantly related to female sex ( r (2)=11.5%, P =0.0001), but not to age, duration of the disease, PD(20) or baseline FEV(1)%. The present study indicates that perception of histamine-induced bronchoconstriction is lower in patients with bronchiectasis and chronic bronchitis than in asthmatic patients, and that sex partially contributes to this difference.
Ekici
Aydanur
A
Department of Pulmonary Medicine, Kirikkale University Faculty of Medicine, 71100 Kirikkale, Turkey.
Yilmaz
Sevda
S
Ekici
Mehmet
M
Kalpaklioğlu
Füsun
F
Karadeniz
Yasemin
Y
Arslan
Mesut
M
Iteginli
Ahmet
A
Kara
Turkan
T
Kurtipek
Ercan
E
D000328:Adult; D000368:Aged; D001249:Asthma / Q000503:physiopathology / Q000523:psychology; D001985:Bronchial Provocation Tests / Q000523:psychology; D001987:Bronchiectasis / Q000503:physiopathology / Q000523:psychology; D029481:Bronchitis, Chronic / Q000503:physiopathology / Q000523:psychology; D016084:Bronchoconstriction; D004417:Dyspnea / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010465:Perception; D012720:Severity of Illness Index; D012737:Sex Factors