title: [A case of metastatic liver tumor of colorectal cancer responding to low-dose CPT-11 chemotherapy].
abstract: We report a case in which low-dose CPT-11 chemotherapy was effective for metastatic liver tumor of sigmoid colon cancer. A 49-year-old male with metastatic liver tumor, who had undergone sigmoidectomy with D2 lymphadenectomy, was treated by low-dose CPT-11 chemotherapy (CPT-11 30 mg/m2 x 3 days, every 2 weeks). After 7 courses of this chemotherapy, CT and ultrasound examinations showed a reduction of tumor size in the liver. This chemotherapy also showed no high grade toxicities. Therefore, low-dose CPT-11 chemotherapy seems to be effective for metastatic colorectal cancer, and safe in view of toxicities.
authors.affiliation: First Dept. of Surgery, Toho University School of Medicine.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Funahashi
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Miki
authors.forename: Junichi
authors.initials: J
authors.lastname: Koike
authors.forename: Naohiro
authors.initials: N
authors.lastname: Washizawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tokuyama
authors.forename: Masamine
authors.initials: M
authors.lastname: Ryu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shiokawa
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Goto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Teramoto
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin