title: KU 70/80 lupus autoantigen is the transcription factor induced by interleukins (IL)-13 and -4 leading to induction of 15-lipoxygenase (15-LO) in human cells.
authors.affiliation: Renal Division, Emory University, Center for Glomerulonephritis, Veterans Affairs Medical Center, Atlanta, GA, USA.
authors.forename: Uddhav
authors.initials: U
authors.lastname: Kelavkar
authors.forename: Susheng
authors.initials: S
authors.lastname: Wang
authors.forename: Kamal
authors.initials: K
authors.lastname: Badr
mesh_terms: D034961:Antigens, Nuclear / Q000235:genetics*; D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics*; D001483:Base Sequence; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000276:immunology; D006801:Humans; D018793:Interleukin-13 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D000072200:Ku Autoantigen; D008175:Lung Neoplasms; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D020545:Respiratory Mucosa / Q000187:drug effects / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics*; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D018793:Interleukin-13; D012333:RNA, Messenger; D014157:Transcription Factors; D015847:Interleukin-4; D001093:Arachidonate 15-Lipoxygenase; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen