title: Medium chain triglycerides as vehicle for palatable oral liquids.
abstract: Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.
authors.affiliation: Pharmaceutical Research & Development, Bristol-Myers Squibb Company, Wilmington, Delaware, USA.
authors.forename: Surendra M
authors.initials: SM
authors.lastname: Bahal
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Romansky
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Alvarez
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D006801:Humans; D019999:Pharmaceutical Solutions / Q000008:administration & dosage*; D013649:Taste / Q000187:drug effects* / Q000502:physiology; D014280:Triglycerides / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D019999:Pharmaceutical Solutions; D014280:Triglycerides