[Gene mapping of a nonsyndromic hearing impairmint family].
OBJECTIVE
To map the gene responsible for nonsyndromic hearing impairment in a consanguineous family.


METHODS
Firstly, X chromosome scanning was used to exclude X chromosome. Secondly, candidate gene analyzing and genome scanning were performed by homozygosity mapping. Then, additional markers flanking the tightly linked marker were tested to confirm linkage and decide the candidate region.


RESULTS
The nonsyndromic hearing impairment of this family was autosomal recessive. Twenty-five known genes were excluded. Autosomal genome scanning indicated that D17S1293 was tightly linked with disease gene. And further study mapped the disease gene to a 5.07 cM interval bounded by D17S1850 and D17S1818.


CONCLUSIONS
The disease gene of the family is mapped to a 5.07 cM interval between D17S1850 and D17S1818, which is a new locus of autosomal recessive nonsyndromic hearing impairment.
Cheng
Lin
L
Department of Medical Genetics, Medical School of Shandong University, Jinan, Shandong, 250012 P. R. China. gongyaoqin@yahoo.com
Gong
Yaoqin
Y
Liu
Qiji
Q
Chen
Bingxi
B
Guo
Chenhong
C
Li
Jiangxia
J
Zhang
Xiyu
X
Lu
Yong
Y
Gao
Guimin
G
Zhou
Haibin
H
Guo
Yishou
Y
D002874:Chromosome Mapping / Q000379:methods; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D003241:Consanguinity; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree