Decrease in human immunodeficiency virus type 1 load during acute dengue fever.
Rather than the expected increase in human immunodeficiency virus type 1 (HIV-1) load, there was transient suppression of HIV-1 replication during acute dengue infection in a 29-year-old Thai woman. Acute-phase (but not convalescent-phase) serum samples obtained from an HIV-1-uninfected patient with dengue fever reduced HIV-1 infectivity, as determined by a peripheral blood mononuclear cell assay, suggesting the possibility that HIV-1 replication is suppressed during acute dengue fever, as occurs during some cases of scrub typhus infection and measles.
Watt
George
G
Department of Retrovirology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. wattgh@thai.amedd.army.mil
Kantipong
Pacharee
P
Jongsakul
Krisada
K
D000208:Acute Disease; D000328:Adult; D003715:Dengue / Q000503:physiopathology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D019562:Viral Load