title: [Single factor study of prognosis from 520 cases with chronic severe hepatitis].
abstract: OBJECTIVE
  To further understand chronic severe hepatitis (CSH) and to improve the level of diagnosis and treatment and to explore the methods to reduce the fatality rate of CSH through analysing the factors related to prognosis of CSH.
  
  
  METHODS
  The factors related to prognosis from 520 cases with CSH were analyzed by SPASS and STATA software.
  
  
  RESULTS
  1. The fatality rate in cases with age > or = 40 years was higher than that in cases with age <40 years (P<0.001), there was no significant difference (P>0.05) in sex and pathogenic basis of CSH; 2. The fatality rate rose in cases with WBC > or = 10.0 x 10(9) per liter or platelet <100 x 10(9) per liter; 3. The fatality rate increased gradually with the ratio of aspartic aminotransferase to alanine aminotransferase (AST/ALT) and serum total bilirubin (TBil), appearance of deviation of TBil and ALT, decrease in prothrombin activity (PTA), total cholesterol (TC), cholinesterase and albumin (Alb) (P<0.001). 4. The fatality rate increased with appearance of complications such as ascites, electrolyte disturbance, spontaneous peritonitis and so on (P<0.001).
  
  
  CONCLUSIONS
  The important factors related to prognosis were age, > or = 40 years, WBC 10.0 x 10(9) per liter or platelet <100 x 10(9) per liter; the ratio of AST/ALT, TBil, Tc, cholinesterase, Alb and complication, to monitor dynamically laboratory indexes such as TBil, PTA, Tc, cholinesterase and so on and to prevent and cure various complications are important measures to reduce the fatality rate of CSH.
authors.affiliation: The 302nd Hospital of PLA, Beijing 100039,China.
authors.forename: Zhengsheng
authors.initials: Z
authors.lastname: Zou
authors.forename: Jumei
authors.initials: J
authors.lastname: Chen
authors.forename: Shaojie
authors.initials: S
authors.lastname: Xin
authors.forename: Hanqian
authors.initials: H
authors.lastname: Xing
authors.forename: Baosen
authors.initials: B
authors.lastname: Li
authors.forename: Jianyu
authors.initials: J
authors.lastname: Li
authors.forename: Honghui
authors.initials: H
authors.lastname: Shen
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002648:Child; D002802:Cholinesterases / Q000097:blood; D051263:D-Alanine Transaminase; D005163:Factor Analysis, Statistical; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012709:Serum Albumin / Q000032:analysis; D013917:Thrombin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D051263:D-Alanine Transaminase; D002802:Cholinesterases; D013917:Thrombin; D001663:Bilirubin