title: Role of radical retropubic prostatectomy in patients with locally advanced prostate cancer: the influence of Gleason score 8-10.
abstract: BACKGROUND
  To define whether in locally advanced prostate cancer submitted to radical retropubic prostatectomy (RRP) the presence of a Gleason score 8-10 represents an index of high risk for progression and cancer-specific death.
  
  
  METHODS
  Finally, a total of 130 men with pathologically confirmed T3 cancer were included in this analysis. On the basis of the histological grade obtained at RRP, patients were divided into two groups: patients with a Gleason score 8-10 (group 1) and patients with a Gleason score <8 (group 2). Postoperative follow-up ranged from 24 to 120 months (median 60). After RRP no patients received additional treatments until a biochemical or clinical disease progression was found. Kaplan-Meier projections were used in each group.
  
  
  RESULTS
  After RRP, 41 patients (31.5%) had a Gleason score 8-10 tumor. The incidence of positive lymph nodes was significantly higher (p = 0.0030) in group 1 (36.6%) when compared with group 2 (12.3%). Significant differences between the two groups were also found with respect to seminal vesicle involvement (p = 0.0045) and positive surgical margins (p = 0.0040). The actuarial cumulative disease-specific survival for group 1 and group 2 was, respectively, 69 and 82% at 10 years. A Kaplan-Meier analysis demonstrated a 100% disease-specific survival, a 92% clinical progression-free survival and a 38% biochemical progression-free survival 10 years postoperatively if patients in group 1 had negative surgical margins and negative lymph nodes (48.8%).
  
  
  CONCLUSIONS
  Our data indicate a significant association between Gleason score 8-10 and disease-specific survival, only if patients in group 1 are stratified on the basis of surgical margins and/or lymph node involvement.
authors.affiliation: Department of Urology U. Bracci, University La Sapienza, V. Policlinico, I-00161 Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sciarra
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Gentile
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Voria
authors.forename: Gianna
authors.initials: G
authors.lastname: Mariotti
authors.forename: Fulvia
authors.initials: F
authors.lastname: Seccareccia
authors.forename: Antonio
authors.initials: A
authors.lastname: Pastore
authors.forename: Franco
authors.initials: F
authors.lastname: Di Silverio
mesh_terms: D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors