title: [Invasive cerebral aspergillosis in an immunocompetent patient: a case report].
abstract: A 32-year-old immunocompetent female presented with sensory aphasia and psychomotor seizure due to aspergillosis in the left temporal lobe spreaded from the left orbita. In spite of oral administration of itraconazole, the symptoms continued to deteriorate due to extension of the lesion to the left temporoparietal white matter. As a result of the stereotactic biopsy of the lesion, she was histologically diagnosed as intracerebral aspergillosis. Intravenous administration of fluconazole and amphotericin B was apparently effective for the lesion, and the symptoms subsided. Ga-67 scintigram could serve as useful adjuncts to magnetic resonance images for evaluation of the therapy. This case is unusual in that an immunocompetent patient suffered from the intracerebral aspergillosis, which invasively spreaded into the parenchyma. We discussed about her pathology, diagnosis, therapy and the route of invasive aspergillosis to the parenchyma.
authors.affiliation: Department of Neurosurgery, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
authors.forename: Yu-to
authors.initials: YT
authors.lastname: Yasokawa
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yano
authors.forename: Satoru
authors.initials: S
authors.lastname: Murase
authors.forename: Jun
authors.initials: J
authors.lastname: Shinoda
authors.forename: Noboru
authors.initials: N
authors.lastname: Sakai
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology*; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D007121:Immunocompetence
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole