title: Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data.
authors.affiliation: Cell Therapeutic, Inc., 201 Elliott Avenue West, Suite 400, Seattle, Washington 98119, USA. jsinger@ctiseattle.com
authors.forename: Jack W
authors.initials: JW
authors.lastname: Singer
authors.forename: Brian
authors.initials: B
authors.lastname: Baker
authors.forename: Peter
authors.initials: P
authors.lastname: De Vries
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Scott
authors.initials: S
authors.lastname: Shaffer
authors.forename: Ed
authors.initials: E
authors.lastname: Vawter
authors.forename: Mary
authors.initials: M
authors.lastname: Bolton
authors.forename: Pamela
authors.initials: P
authors.lastname: Garzone
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D002986:Clinical Trials as Topic; D006801:Humans; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011099:Polyglutamic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000031:analogs & derivatives; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D011099:Polyglutamic Acid; D017239:Paclitaxel; C509139:paclitaxel poliglumex