title: Treatment of central nervous system infection by vancomycin-resistant enterococcus faecium.
abstract: Enterococci are uncommon causes of CNS infection. We describe a case of ventriculitis and Ommaya reservoir infection due to vancomycin-resistant Enterococcus faecium successfully treated with the combination of i.v. quinupristin/dalfopristin and i.v. linezolid. The patient deteriorated after receiving three dosages of intraventricular quinupristin/dalfopristin. He recovered after discontinuation of intraventricular quinupristin/dalfopristin.
authors.affiliation: Southern Illinois University School of Medicine, Springfield, Illinois, USA.
authors.forename: Termkiat
authors.initials: T
authors.lastname: Kanchanapoom
authors.forename: Janak
authors.initials: J
authors.lastname: Koirala
authors.forename: James
authors.initials: J
authors.lastname: Goodrich
authors.forename: Edem
authors.initials: E
authors.lastname: Agamah
authors.forename: Nancy
authors.initials: N
authors.lastname: Khardori
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D002494:Central Nervous System Infections / Q000188:drug therapy* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D005500:Follow-Up Studies; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D015552:Injections, Intralesional; D008223:Lymphoma / Q000175:diagnosis / Q000532:radiotherapy; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D018570:Risk Assessment; D016896:Treatment Outcome; D014640:Vancomycin / Q000494:pharmacology*; D014769:Virginiamycin / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014769:Virginiamycin; C113825:quinupristin; D014640:Vancomycin; C113826:dalfopristin