Gastrointestinal transit of liquids in unfed cynomolgus monkeys.
In this study, the gastric emptying rate and oro-caecal transit time of two liquid volumes (20 and 60 ml) were compared in unfed cynomolgus monkeys. First, the acetaminophen method was used to determine the gastric half-emptying time (t(50%)). The mean t(50%) from seven monkeys was 21.2 min for the 20-ml volume and 27.8 min for the 60-ml volume. This mean t(50%) in monkeys is similar to that reported previously in fasting humans. Next, the sulfasalazine-sulfapyridine method was used to determine median oro-caecal transit times for the 2 liquid volumes; these times were 2.5 h for the 20-ml volume and 2.3 h for the 60-ml volume, which are about 1.5 h shorter than previously reported transit times in humans. An increase in volume administered did not significantly change either the t(50%) or oro-caecal transit time. The data also show that variability in both t(50%) and oro-caecal transit time within each monkey is not as great as the large variability between monkeys. Consequently, cynomolgus monkeys are good model animals to use for studies on the gastric emptying of drug-containing liquids after fasting; however, analysis of results from bioavailability studies must compensate for differences in the oro-caecal transit time between monkeys and humans.
Kondo
Hiromu
H
Novel Pharmaceutical Laboratories, Institute for Technology Development, Yamanouchi Pharmaceutical Co., Ltd., 180 Ozumi, Yaizu-shi, Shizuoka 425-0072, Japan. kondo@yamanouchi.co.jp
Takahashi
Yutaka
Y
Watanabe
Takashi
T
Yokohama
Shigeharu
S
Watanabe
Jun
J
D000818:Animals; D005508:Food Deprivation / Q000502:physiology*; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology; D005772:Gastrointestinal Transit / Q000187:drug effects* / Q000502:physiology*; D008252:Macaca fascicularis; D008297:Male; D019999:Pharmaceutical Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics
D019999:Pharmaceutical Solutions