title: [Progress in somatic gene therapy].
abstract: Therapeutic gene transfer may constitute an alternative to current treatments. Despite promising results from animal studies common use of genes as drugs awaits improved vector efficiency and easier large-scale vector production. New developments in the field include high-capacity vectors with low immunogenicity, hybrid vectors, site-specific vector integration, RNA interference, and efficient non-viral gene transfer. In this article, we review the recent progress in somatic gene therapy with focus on vector development and current examples of clinical efficiency.
authors.affiliation: Stanford University School of Medicine, Departments of Pediatrics and Genetics, USA.
authors.forename: Jacob Giehm
authors.initials: JG
authors.lastname: Mikkelsen
authors.forename: Thomas Gryesten
authors.initials: TG
authors.lastname: Jensen
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans