title: Pramipexole in comparison to l-dopa: a neuropsychological study.
abstract: Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on l-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while l-dopa did not. Moreover, pramipexole opposite to l-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.
authors.affiliation: IRCCS Fondazione S. Lucia.
authors.forename: L
authors.initials: L
authors.lastname: Brusa
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: A
authors.initials: A
authors.lastname: Stefani
authors.forename: M
authors.initials: M
authors.lastname: Pierantozzi
authors.forename: A
authors.initials: A
authors.lastname: Peppe
authors.forename: M D
authors.initials: MD
authors.lastname: Caramia
authors.forename: L
authors.initials: L
authors.lastname: Boffa
authors.forename: S
authors.initials: S
authors.lastname: Ruggieri
authors.forename: P
authors.initials: P
authors.lastname: Stanzione
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D052160:Benzothiazoles; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D000077487:Pramipexole; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D052160:Benzothiazoles; D013844:Thiazoles; D007980:Levodopa; D000077487:Pramipexole