title: [Features of onset of chronic severe hepatitis in 520 cases].
abstract: OBJECTIVE
  To discuss features of onset of chronic severe viral hepatitis (CSH).
  
  
  METHODS
  The patterns of onset of 520 cases of CSH were analyzed by SPASS and STATA software.
  
  
  RESULTS
  1. Within less than 10 days, less than 2 weeks, 2 to 4 weeks, 4 weeks to 6 months, 10.4%, 18.1%, 17.1% and 64.8% of 520 cases deteriorated into severe hepatitis respectively. 2. There were no definite predisposing factors in more than 40% cases. There were 1 to 3 or more predisposing factors in more than 30% cases. The incidence of concurrent infection was the highest (P<0.01). 3. The pathogenic basis in more than 50% cases was cirrhosis. 4. Hepatic encephalopathy did not occur in more than 50% of the cases. Ascites occurred in more than 75% of cases. Hepatic encephalopathy first occurred in less than 5% cases and ascites in more than 10% of cases. 5. The latest time for occurrence of hepatic encephalopathy was later than the time of deteriorating into severe hepatitis.
  
  
  CONCLUSIONS
  1. Gradual deterioration into CSH was found in all the 520 cases. 2. The predisposing factors, pathogenic bases, incidence and occurring time of hepatic encephalopathy, firstly occurring complication and so on in CSH are not the same as those in acute and subacute severe hepatitis. Therefore, CSH should be independently named and the study of CSH should be strengthened.
authors.affiliation: The 302nd Hospital of PLA, Beijing 100039, China.
authors.forename: Zhengsheng
authors.initials: Z
authors.lastname: Zou
authors.forename: Jumei
authors.initials: J
authors.lastname: Chen
authors.forename: Shaojie
authors.initials: S
authors.lastname: Xin
authors.forename: Hanqian
authors.initials: H
authors.lastname: Xing
authors.forename: Baosen
authors.initials: B
authors.lastname: Li
authors.forename: Jianyu
authors.initials: J
authors.lastname: Li
authors.forename: Honghui
authors.initials: H
authors.lastname: Shen
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology; D002648:Child; D005260:Female; D006501:Hepatic Encephalopathy / Q000209:etiology; D006521:Hepatitis, Chronic / Q000150:complications*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies