Nuclear hormone receptor assays for drug discovery.
Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that control diverse aspects of growth, development and homeostasis, making them exciting and important targets for drug discovery. In this review, some of the recent advances in our understanding of NRs, and their application to the discovery of new ligands, will be discussed.
Rosen
Jon
J
Department of Molecular & Cell Biology, Ligand Pharmaceuticals Inc, 10275 Science Center Drive, San Diego, CA 92121, USA. jrosen@ligand.com
Marschke
Keith
K
Rungta
Deepa
D
D000818:Animals; D004353:Drug Evaluation, Preclinical; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D010600:Pharmacology / Q000379:methods*; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects*
D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear