[Mapping studies of type 2 diabetes mellitus gene in one family].
OBJECTIVE
To disclose the molecular genetic mechanism of type 2 diabetes mellitus and to determine chromosomal location of type 2 diabetes mellitus gene.


METHODS
Genome-wide screening and genotyping were conducted in a family of type 2 diabetes mellitus, and linkage analysis by LINKAGE and GENEHUNTER package was used to determine the potential chromosomal location of the family of type 2 diabetes mellitus gene.


RESULTS
Evidence of linkage was found at the long arm of chromosome 2. The maximum Lod score is 1.80 and non-parameter Lod score is 5.06.


CONCLUSIONS
The type 2 diabetes mellitus gene of the family is located at 2q.
Li
Yuebin
Y
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200032 P. R. China. liybman@hotmail.com
Lu
Hong
H
Liu
Wei
W
Zhang
Chenhui
C
Xiong
Xiaoyan
X
Xu
Shijie
S
Huang
Wei
W
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree