title: Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures.
abstract: The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 microM) inhibited 50 min OGD-, 20 microM N-methyl-D-aspartate (NMDA)-, and 50 microM kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl(2), and FeCl(2). These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.
authors.affiliation: Department of Veterinary Medicine, Cheju National University, South Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Ha
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kwon
authors.forename: Shin Mi
authors.initials: SM
authors.lastname: Park
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Park
authors.forename: Hyoung Chun
authors.initials: HC
authors.lastname: Kim
authors.forename: Myung Sang
authors.initials: MS
authors.lastname: Kwon
authors.forename: Myung Bok
authors.initials: MB
authors.lastname: Wie
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015687:Cell Hypoxia / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity*; D005947:Glucose / Q000172:deficiency*; D007608:Kainic Acid / Q000633:toxicity; D051379:Mice; D008813:Mice, Inbred ICR; D016202:N-Methylaspartate / Q000633:toxicity; D009457:Neuroglia / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate; D011794:Quercetin; D005947:Glucose; D010100:Oxygen; D007608:Kainic Acid