Role of vascular factors in osteoporosis.
Osteoporosis is a silent epidemic in the world today. With the increase in the elderly population, there will be an increase in the prevalence of osteoporosis, and so the need for focused preventive strategies should become a public health priority. Prophylactic therapy and risk-factor reduction is important, as this is likely to be cost effective. There are scientific observations that point out that vascular dysfunction seen with aging may be related to the pathogenesis of osteoporosis. Here we review this relationship from a different angle. We think aggressive control of vascular risk factors in addition to the known existing osteoporosis risk factors may help to reduce the morbidity and mortality associated with this disease.
Alagiakrishnan
Kannayiram
K
Division of Geriatric Medicine, University of Alberta, Edmonton, Canada. kalagiak@cha.ab.ca
Juby
Angela
A
Hanley
David
D
Tymchak
Wayne
W
Sclater
Anne
A
D000437:Alcoholism / Q000150:complications; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D001341:Autonomic Nervous System / Q000503:physiopathology; D001842:Bone and Bones / Q000098:blood supply*; D003069:Coffee / Q000009:adverse effects; D048909:Diabetes Complications; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008833:Microcirculation; D009569:Nitric Oxide / Q000502:physiology; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014807:Vitamin D / Q000502:physiology
D001057:Apolipoproteins E; D003069:Coffee; D014807:Vitamin D; D009569:Nitric Oxide