ER-mediated phagocytosis: a new membrane for new functions.
Genomics and other high-throughput approaches, such as proteomics, are changing the way we study complex biological systems. In the past few years, these approaches have contributed markedly to improving our understanding of phagocytosis. Indeed, the ability to study biological systems by monitoring hundreds of proteins provides a level of resolution that is not attainable by the usual 'one protein at a time' approach. In this article, I discuss how proteomic approaches have revealed surprising findings that enable us to revisit established concepts, such as the origin of the phagosome membrane, and to propose new models of cell organization and the link between innate and adaptive immunity.
Desjardins
Michel
M
Département de pathologie et biologie cellulaire, Université de Montréal and Caprion Pharmaceuticals, Montreal, Canada. michel.desjardins@umontreal.ca
D000818:Animals; D017951:Antigen Presentation; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D021962:Membrane Microdomains / Q000276:immunology / Q000648:ultrastructure; D008565:Membrane Proteins / Q000276:immunology; D018448:Models, Immunological; D010587:Phagocytosis / Q000276:immunology*; D010588:Phagosomes / Q000276:immunology / Q000648:ultrastructure; D040901:Proteomics
D008565:Membrane Proteins