title: Studies on gastrointestinal hormone and jejunal interdigestive migrating motor complex in patients with or without early dumping syndrome after total gastrectomy with Roux-en-Y reconstruction for early gastric cancer.
abstract: BACKGROUND
  There has been no report concerning fasting Roux limb motilities and gut hormone in patients with early dumping syndrome (EDS) after total gastrectomy with Roux-en-Y reconstruction. The present study investigated interdigestive migrating motor complex, phase III (IMMC-pIII) in the Roux limb, changes in the plasma gut hormone levels, and the relationships among those parameters and EDS.
  
  
  METHODS
  Forty-eight patients (35 men, 13 women; aged 33 to 69 years, mean, 59.8) 1.5 to 2.0 years (mean 1 year, 8 months) after total gastrectomy with Roux-en-Y reconstruction for early gastric cancer were allocated to two groups based on the presence or absence of EDS. The occurrence of IMMC-pIII was compared and changes in the plasma levels of both motilin (MT) and somatostatin (SOM) were monitored.
  
  
  RESULTS
  None of the patients with EDS (n = 8) were recognized as having IMMC-pIII. In the IMMC-pIII positive group, MT and SOM increased sequentially from phase I through IMMC-pIII. In the IMMC-pIII negative group, MT and SOM were significantly lower than in the IMMC-pIII positive group during phases I, II, and IMMC-pIII (P <0.05, P <0.01, P <0.01, respectively).
  
  
  CONCLUSIONS
  There is an absence of IMMC-pIII in patients with EDS, and both MT and SOM might be necessary for IMMC-pIII generation.
authors.affiliation: First Department of Surgery, Nihon University School of Medicine, Tokyo 173-0032, Japan. rtomita-ndus@mvg.biglobe.ne.jp
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Tanjoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukuzawa
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y / Q000009:adverse effects*; D004377:Dumping Syndrome / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005768:Gastrointestinal Hormones / Q000097:blood / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007583:Jejunum / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood / Q000502:physiology; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009367:Neoplasm Staging; D013004:Somatostatin / Q000097:blood / Q000502:physiology; D013274:Stomach Neoplasms / Q000601:surgery*
chemical_list: D005768:Gastrointestinal Hormones; D013004:Somatostatin; D009037:Motilin