title: Inhibitory role of Syzygium cumini on autacoid-induced inflammation in rats.
abstract: The ethanolic extract of Syzygium cumini bark has been reported to possess anti-inflammatory activity in our previous studies. The present study is an attempt to elucidate the anti-inflammatory activity of S. Cumini bark against inflammation induced by individual autacoid insult. Histamine (1 mg/ml), 5-HT (1 mg/ml), bradykinin (0.02 mg/ml) and PGE2 (0.001 mg/ml) were used as inflammogens. One of these agents (0.1 ml) was injected s.c. into the right hind paw of each rat. The ethanolic extract of S. cumini bark was tested at the doses of 100, 300 and 1000 mg/kg, p.o. The results indicated the anti-inflammatory activity of S. cumini bark in histamine, 5-HT and PGE2-induced rat paw oedema. However, there was no such significant inhibition of oedema volume observed in bradykinin-induced rat paw oedema at any dose level. Thus, it is concluded that S. cumini exhibits inhibitory role on inflammatory response to histamine, 5-HT and PGE2.
authors.affiliation: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar-243 122.
authors.forename: S
authors.initials: S
authors.lastname: Muruganandan
authors.forename: S
authors.initials: S
authors.lastname: Pant
authors.forename: K
authors.initials: K
authors.lastname: Srinivasan
authors.forename: S
authors.initials: S
authors.lastname: Chandra
authors.forename: S K
authors.initials: SK
authors.lastname: Tandan
authors.forename: J
authors.initials: J
authors.lastname: Lal
authors.forename: Ravi V
authors.initials: RV
authors.lastname: Prakash
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D012898:Autacoids / Q000633:toxicity*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D027842:Syzygium
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012898:Autacoids; D010936:Plant Extracts