title: A comparison of familial and sporadic migraine in a headache clinic population.
abstract: We compared the clinical, psychological and pharmacological characteristics of patients with familial migraine and patients with sporadic migraine. Five hundred and thirty consecutive new patients attending our Headache Center over a two-year period were involved in the study. The patients were divided into two groups: A. Familial migraine (famM)--at least one first-degree relative affected; B. Sporadic migraine (spoM)--no first-degree relative affected. Four hundred and twenty-four patients (80%) fulfilled the criteria for famM and 106 (20%) for spoM. The patients with famM showed a significantly (p<0.01) earlier age at onset of the disease. No significant difference in all the remaining features examined was found. Our data suggest that famM and spoM represent a single disease entity.
authors.affiliation: Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy. irainero@molinette.piemonte.it
authors.forename: Innocenzo
authors.initials: I
authors.lastname: Rainero
authors.forename: Walter
authors.initials: W
authors.lastname: Valfrè
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gentile
authors.forename: Rossana
authors.initials: R
authors.lastname: Lo Giudice
authors.forename: Margherita
authors.initials: M
authors.lastname: Ferrero
authors.forename: Lidia
authors.initials: L
authors.lastname: Savi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pinessi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001007:Anxiety / Q000523:psychology; D002648:Child; D003863:Depression / Q000523:psychology; D005260:Female; D005502:Food; D006261:Headache / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D020325:Migraine with Aura / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D020326:Migraine without Aura / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D023303:Oxazolidinones / Q000627:therapeutic use; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D012727:Sex Characteristics; D018170:Sumatriptan / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D014363:Tryptamines
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D023303:Oxazolidinones; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C089750:zolmitriptan; D018170:Sumatriptan