title: 192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation.
abstract: Rats with bilateral 192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) were tested on olfactory discrimination learning set (ODLS), olfactory discrimination reversal learning set (DRLS), and open field activity. Control animals demonstrated learning set in both the ODLS and DRLS tasks. The nBM-lesioned animals showed initial acquisition impairment in learning set in the ODLS task but eventually demonstrated learning set in both ODLS and DRLS tasks. There were no group differences in open-field activity. Results suggest that removal of the nBM cholinergic system through 192 IgG-saporin lesions impairs early acquisition of learning set compared to control animals, but does not prevent later use of learning set formation. Implications for the non-cholinergic basal forebrain cells in learning set are discussed.
authors.affiliation: Department of Psychology, St. Mary's College of Maryland, 18952 E. Fisher Road, St. Mary's City, MD 20686-3001, USA. ambailey@smcm.edu
authors.forename: Aileen M
authors.initials: AM
authors.lastname: Bailey
authors.forename: Meghan L
authors.initials: ML
authors.lastname: Rudisill
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Hoof
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Loving
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology*; D020532:Basal Nucleus of Meynert / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000473:pathology; D018678:Cholinergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D000922:Immunotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009699:N-Glycosyl Hydrolases; D051381:Rats; D020318:Rats, Long-Evans; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D012718:Set, Psychology; D012903:Smell / Q000187:drug effects*
chemical_list: C085696:192 IgG-saporin; D000911:Antibodies, Monoclonal; D018678:Cholinergic Agents; D000922:Immunotoxins; D054789:Ribosome Inactivating Proteins, Type 1; D000110:Acetylcholinesterase; D009699:N-Glycosyl Hydrolases; D000076985:Saporins