Modulatory effect of fosfomycin on acute inflammation in the rat air pouch model.
We examined the effect of fosfomycin (FOM) on the inflammatory response induced by carrageenan in the rat. Air pouches were induced subcutaneously on the backs of rats and injected with carrageenan. The rats were treated with either vehicle or FOM at a dose of 100 mg/kg 1 h before carrageenan challenge. After carrageenan challenge (48 h), the air pouches were removed and analyzed. The volume, protein amounts and cell counts in the exudate obtained from FOM-treated animals were significantly reduced compared with that from vehicle-treated animals. The contents of PGE(2) and TNF-alpha, and mRNA for cyclooxygenase-2 were also markedly suppressed in FOM-treated rats. Histological examination showed suppression of the inflammatory response in the pouch tissues from FOM-treated rats.
Morikawa
K
K
Department of Nutrition, Division of Clinical Nutrition, Sagami Women's University, 2-1-1 Bunkyo, Sagamihara, Kanagawa 228-8533, Japan. morikawa_keiko@isc.sagami-wu.ac.jp
Nonaka
M
M
Torii
Ikuko
I
Morikawa
S
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D018946:Chemokine CCL5 / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000166:cytology / Q000502:physiology*; D005578:Fosfomycin / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D018946:Chemokine CCL5; D014409:Tumor Necrosis Factor-alpha; D005578:Fosfomycin; D015232:Dinoprostone