title: [Application of SCID mouse-human leukemia model for leukemia research].
abstract: SCID mouse-human leukemia model is an important and useful tool for study on proliferation, differentiation and modulation of leukemic cells. In this article, the establishment of the model, advances in research and application in studies of pathogenesis, cell biology, clinical diagnosis, therapy and assessment of prognosis of leukemia patients are reviewed. The limitations of the model are also commented.
authors.affiliation: Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiao-Meng
authors.initials: XM
authors.lastname: Nie
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Lou
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D051379:Mice; D016513:Mice, SCID; D012107:Research Design