title: Acquired T-helper 1 lymphocyte anergy following infection with Mycobacterium ulcerans.
abstract: We describe a patient with acquired T-helper lymphocyte anergy to mycobacteria following infection with Mycobacterium ulcerans. Before infection, the patient's peripheral blood mononuclear cells responded to in vitro stimulation with M. ulcerans by producing Th1 cytokines, but, after she developed an ulcer, the response was shifted toward production of Th2 cytokines. Immunomodulatory therapy may be an effective intervention for Buruli ulcer.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Travis M
authors.initials: TM
authors.lastname: Gooding
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Kemp
authors.forename: Roy M
authors.initials: RM
authors.lastname: Robins-Browne
authors.forename: May
authors.initials: M
authors.lastname: Smith
authors.forename: Paul D R
authors.initials: PD
authors.lastname: Johnson
mesh_terms: D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology*; D019911:Mycobacterium ulcerans / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines