Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes.
Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P= .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.
Choi
Eun Hwa
EH
Section of Genomic Variation, Pediatric Oncology Branch, National Cancer Institute/NIH, Advanced Technology Center, Gaithersburg, MD 20892-4605, USA.
Foster
Charles B
CB
Taylor
James G
JG
Erichsen
Hans Christian
HC
Chen
Renee A
RA
Walsh
Thomas J
TJ
Anttila
Veli-Jukka
VJ
Ruutu
Tapani
T
Palotie
Aarno
A
Chanock
Stephen J
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications* / Q000235:genetics*; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D007938:Leukemia / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic / Q000235:genetics*
D015847:Interleukin-4