Medical management of prolactin-secreting pituitary adenomas.
Prolactinomas are a common cause of reproductive/sexual dysfunction. Once other causes of hyperprolactinemia have been excluded with a careful history and physical examination, routine chemistries, a pregnancy test and a TSH, imaging with MRI or CT will delineate the size and extent of the tumor. Medical therapy is the initial treatment of choice. When infertility is the primary indication for treatment, bromocriptine use has an extensive safety experience and is preferred. However, for other indications, cabergoline appears to be more efficacious and better tolerated. Transsphenoidal surgery remains an option, especially for patients with microadenomas, when medical therapy is ineffective.
Molitch
Mark E
ME
Center for Endocrinology, Metabolism and Molecular Medicine, North western University, The Feinberg Medical School, Chicago, IL 60611, USA. molitch@northwestern.edu
D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000473:pathology; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery
D018491:Dopamine Agonists