title: [Bioclinical correlations in bony metastases. Results of a prospective study. 60 cases].
abstract: Our objective is to compare clinical and biological presentation of patients with bone metastatic disease.
  
  
  METHODS
  We collected prospectively 60 patients (adults and children) with proven bone metastasis. Tumors are mainly breast cancer (25/60) or nasopharyngeal carcinoma (8/60). All 8 children presented all with abdominal neuroblastoma. Bone lesions are lytic in 85% of cases. ALP and LDH seem to be sensitive markers for bone mestatasis with 75% and 80% pathologic rates. The highest rates have been observed in patients with multiple bones lesions (> 8) and painful metastases (more than 7 in the VAS). The median survival was 8 months (3 to 54).
  
  
  CONCLUSIONS
  Even conventional, some biochemical markers as ALP and LDH remain useful in the diagnosis and prognosis in patients with proven bone metastasis.
authors.affiliation: Institut Salah Azaiz Tunis.
authors.forename: Raja
authors.initials: R
authors.lastname: Belhaj
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Abderraouf
authors.initials: A
authors.lastname: Ghanem
authors.forename: Saloua
authors.initials: S
authors.lastname: Essafer
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.forename: Farhat
authors.initials: F
authors.lastname: Ben Ayed
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014416:Tunisia / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase