title: Topiramate and word-finding difficulties in patients with epilepsy.
abstract: OBJECTIVE
  To evaluate the prevalence of word-finding difficulties as a treatment-emergent adverse event in patients with epilepsy taking topiramate and to identify a clinical phenotype at risk.
  
  
  METHODS
  The authors investigated the relationship of word-finding difficulties to topiramate titration schedule, seizure frequency and pattern, and EEG and neuroradiologic findings in 431 consecutively and prospectively collected patients taking topiramate.
  
  
  RESULTS
  Thirty-one patients (7.2%) developed word-finding difficulties. Presence of simple partial seizures (OR = 6.7 p = 0.007) and a left temporal EEG epileptic focus (OR = 5.2 p = 0.021) were significantly associated with word-finding difficulties.
  
  
  CONCLUSIONS
  The presence of word-finding difficulties seems to be a titration schedule independent phenomenon that occurs in a subgroup of patients with a specific biologic vulnerability.
authors.affiliation: Department of Clinical & Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Mula
authors.forename: Michael R
authors.initials: MR
authors.lastname: Trimble
authors.forename: Pamela
authors.initials: P
authors.lastname: Thompson
authors.forename: Josemir W A S
authors.initials: JW
authors.lastname: Sander
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001037:Aphasia / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D015984:Causality; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D000077236:Topiramate; D006113:United Kingdom / Q000453:epidemiology; D014705:Verbal Behavior / Q000187:drug effects*
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose