188Re-labeled hydroxyapatite particles for radiation synovectomy.
A new procedure for labeling hydroxyapatite (HA) particles with 188Re for radiation synovectomy is described and standardized. The particles were labeled with 188Re in high yields (99%) in acidic medium. HA particle size remained unaffected by reaction conditions as checked by laser diffraction particle analyzer. 188Re-HA was found to be stable retaining 99% radiochemical purity after 4 days when stored in ascorbic acid solution (10mg/ml, pH 5). Intra-articular injection in rats revealed approximately 98% retention of 188Re-HA in the knee after 48-h pi.
Kothari
K
K
Radiopharmaceuticals Section, Isotope Division, Bhabha Atomic Research Center, Mumbai, 400 085, India. ambi@magnum.barc.ernet.in
Suresh
S
S
Sarma
H D
HD
Meera
V
V
Pillai
M R A
MR
D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry; D004355:Drug Stability; D006882:Hydroxyapatites / Q000737:chemistry* / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D007553:Isotope Labeling; D007834:Lasers; D010316:Particle Size; D011835:Radiation Protection / Q000295:instrumentation*; D011868:Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use*; D016634:Radiosurgery / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry* / Q000627:therapeutic use*; D000074402:Synovectomy; D013997:Time Factors
D006882:Hydroxyapatites; D011868:Radioisotopes; D012211:Rhenium; D001205:Ascorbic Acid