Hyaline vascular Castleman's disease: a case report and brief review of the literature.
We describe a 27-year-old female with a mesenterial localisation of the hyaline vascular type of Castleman's disease. A review of the literature is given with emphasis on the different pathogenesis of the subtypes. The hyaline vascular type is a disorder of stromal cells, which can be complicated by the development of soft tissue sarcomas. The plasma cell type is a plasma cell disorder with elevated levels of interleukin-6 (IL-6). In the multicentric type, infection with human herpes virus-8 (HHV-8) plays an important role in the pathogenesis. The development of Kaposi's sarcoma and some lymphomas are related to the presence of HHV-8. As the different subtypes have a different pathogenesis they should be regarded as distinct diseases.
van den Berge
M
M
Department of Internal Medicine, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands.
Pauwels
P
P
Jakimowicz
J J
JJ
Creemers
G J
GJ
D000328:Adult; D005871:Castleman Disease / Q000276:immunology / Q000473:pathology* / Q000628:therapy / Q000821:virology; D005260:Female; D019288:Herpesvirus 8, Human; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D012514:Sarcoma, Kaposi / Q000150:complications; D014057:Tomography, X-Ray Computed
D015850:Interleukin-6