Biochemical evaluation of multiple herbal treatments in alloxan-induced diabetes in Wistar rats.
Alloxan-induced diabetic rats were treated with multiple herbal preparation besides a control group receiving distilled water. The levels of glucose and alkaline phosphatase (ALP) increased abnormally in the alloxan treated group and the same were normalized upon treatment with the herbal preparation. The levels of blood urea nitrogen (BUN), alanine aminotransferase (ALT), protein and albumin in all groups remained unaltered. However, weekly body weight gain which got significantly altered in the alloxan-treated group was normalized by treatment with the herbal preparation. On the whole, a profound hypoglycemic effect was observed by the multiple herbal treatment in the diabetic rats.
Kumar
T
T
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology, Padappai-601 301, India.
Stanley
V Amalan
VA
Lal
A Arun Sam
AA
Balasubramanian
M
M
Pillai
K Sadasivan
KS
D000410:Alanine Transaminase / Q000032:analysis / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000032:analysis / Q000494:pharmacology; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000662:veterinary; D004195:Disease Models, Animal; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D008297:Male; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D028321:Plant Preparations; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005947:Glucose