title: QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA.
abstract: The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q(2) (0.741) and r(2) (0.960) values, gave reliability to the prediction of inhibitory activity of this series.
authors.affiliation: School of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea. hypark@mm.ewha.ac.kr
authors.forename: Hea-Young Park
authors.initials: HY
authors.lastname: Choo
authors.forename: Suyoung
authors.initials: S
authors.lastname: Choi
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Hwa-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: In Young
authors.initials: IY
authors.lastname: Lee
authors.forename: Ae Nim
authors.initials: AN
authors.lastname: Paeb
authors.forename: Hun Yeong
authors.initials: HY
authors.lastname: Koh
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D021281:Quantitative Structure-Activity Relationship; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
chemical_list: D011804:Quinolines