Chain length is the main determinant of the folding rate for proteins with three-state folding kinetics.
We demonstrate that chain length is the main determinant of the folding rate for proteins with the three-state folding kinetics. The logarithm of their folding rate in water (k(f)) strongly anticorrelates with their chain length L (the correlation coefficient being -0.80). At the same time, the chain length has no correlation with the folding rate for two-state folding proteins (the correlation coefficient is -0.07). Another significant difference of these two groups of proteins is a strong anticorrelation between the folding rate and Baker's "relative contact order" for the two-state folders and the complete absence of such correlation for the three-state folders.
Galzitskaya
Oxana V
OV
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. ogalzit@vega.protres.ru
Garbuzynskiy
Sergiy O
SO
Ivankov
Dmitry N
DN
Finkelstein
Alexei V
AV
D007700:Kinetics; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D011506:Proteins