title: Antidepressant response and fluvoxamine plasma concentrations: a pilot study.
abstract: The objective of this pilot study was to examine the relation between fluvoxamine (FVX) plasma concentrations, therapeutic response and side effects during a four-week treatment period. Twenty-two patients who met the DSM-IV criteria for major depression received 100 mg FVX during the first 2 days of treatment and then 150 or 200 mg/day. No clear relationship between plasma concentrations and side effects was detectable. A relationship between plasma concentrations and clinical efficacy was detectable after 21 days but not after 28 days of treatment. These preliminary results indicate that therapeutic drug monitoring might be useful for patients treated with FVX.
authors.affiliation: Pharmacy, Psychiatric Hospital, F-25150 Novillars, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Schwarzenbach
authors.forename: Christian
authors.initials: C
authors.lastname: Netillard
authors.forename: Patricia
authors.initials: P
authors.lastname: Demoly
authors.forename: Dorothé
authors.initials: D
authors.lastname: Bisschop
authors.forename: Samuel
authors.initials: S
authors.lastname: Limat
authors.forename: Serge
authors.initials: S
authors.lastname: Bouquet
authors.forename: Sylvette
authors.initials: S
authors.lastname: Vandel
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bel
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Woronoff-Lemsi
mesh_terms: D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016666:Fluvoxamine