A family with abdominal aortic aneurysms.
This investigation focused on 7 siblings to 2 brothers with abdominal aortic aneurysm (AAA), with respect to AAA, Chlamydia pneumoniae (CP) serology, serum cholesterol, and smoking habits. Five male and 4 female siblings were included. All siblings underwent ultrasonography, and surgical specimens from the aorta were prepared for immunohistochemical (IHC) analysis. Blood was obtained from all living siblings and serum cholesterol level was analyzed. Serologic analysis was done by microimmunofluorescence (MIF). Smoking habits were recorded. In addition to the 2 known siblings with AAA, 2 other brothers with AAA were found. Four of 8 siblings had IgG 1/512 or greater and 7 of 8 had IgA 1/64 or greater. Two of 3 were positive for CP in IHC obtained from aortic specimens. Two of 8 had hypercholesterolemia; 7 of 9 were smokers. C. pneumoniae as well as smoking seems to be important in the pathogenesis of AAA in this small cohort; however, larger patient cohorts are needed.
Karlsson
Lars
L
Department of Surgery, University Hospital Uppsala, Uppsala, Sweden.
Gnarpe
Judy
J
Olsson
Gunnar
G
Gnarpe
Håkan
H
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology / Q000235:genetics* / Q000601:surgery; D023521:Chlamydophila Infections / Q000150:complications; D016993:Chlamydophila pneumoniae; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects
D007070:Immunoglobulin A; D007074:Immunoglobulin G