Expression of cycloxygenase-2 in human bladder and renal cell carcinoma.
In summary, we have showed that levels of COX-2 are increased in both TCC and RCC derived from urinary tract epithelium as well as gastrointestinal cancer. These results raised the possibility that selective inhibitors of COX-2 may be useful in the prevention or treatment of these diseases.
Hara
Shuntaro
S
Kitasato University, School of Pharmaceutical Sciences, Tokyo 108-8641, Japan.
Kondo
Yukihiro
Y
Matsuzawa
Ichiro
I
Hashimoto
Yoshitaka
Y
Kimura
Go
G
Akimoto
Masaso
M
Imura
Nobumasa
N
D001483:Base Sequence; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000235:genetics; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000235:genetics; D051546:Cyclooxygenase 2; D017931:DNA Primers; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000235:genetics; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001743:Urinary Bladder / Q000201:enzymology*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000235:genetics
D017931:DNA Primers; D007527:Isoenzymes; D008565:Membrane Proteins; D012333:RNA, Messenger; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases