title: Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors.
abstract: The authors studied 16 consecutive cases of cerebral venous thrombosis (CVT). Clinical outcome was good or excellent in 14 patients. Comprehensive hypercoagulable screening was done at least 3 months after the onset of CVT, including evaluation of genetic coagulation disorders and plasma levels of homocysteine and factor VIII. This screening was positive in 12 patients (75%). An acquired prothrombotic factor was identified in 9 of these 12 patients. Elevation of factor VIII plasma level was the most common coagulation disorder (8 patients).
authors.affiliation: Service d'Urgences Neurovasculaires, Hôpital Neurologique, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Cakmak
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: M
authors.initials: M
authors.lastname: Berruyer
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: F
authors.initials: F
authors.lastname: Philippeau
authors.forename: P
authors.initials: P
authors.lastname: Adeleine
authors.forename: M
authors.initials: M
authors.lastname: Hermier
authors.forename: J C
authors.initials: JC
authors.lastname: Froment
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography; D004185:Disability Evaluation; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008403:Mass Screening; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006710:Homocysteine; D005169:Factor VIII; D006493:Heparin