title: Plasma-associated halogenated phenolic contaminants in benthic and pelagic fish species from the Detroit River.
abstract: Halogenated phenolic contaminants (HPCs), polychlorinated biphenyls (PCBs), and other organochlorine (OC) contaminants (DDTs, chlordanes, HCH, and octachlorostyrene (OCS)) were determined (ng/g, wet wt basis) in the blood plasma of 6 piscivorous/pelagic- and 7 benthic-feeding fish species from the Detroit River. Seven to twelve hydroxylated (OH) PCB congeners with pentachloro- to nonachloro-substitution, pentachlorophenol (PCP) and 4-OH-heptachlorostyrene (4-OH-HpCS), as well as a number of other unidentified HPCs, were detected in all the fish species studied. The concentrations of sigma-OH-PCB (0.57-129.5 ng/ g), 4-OH-HpCS (0.02-0.31 ng/g), and PCP (0.05-3.42 ng/ g) in comparison to other major polychlorinated contaminants (sigma-PCB (10.4-909.0 ng/g), sigma-chlordane (0.72-8.68 ng/g), sigma-DDT (2.10-66.57 ng/g), and sigma-HCH (0.04-0.84 ng/g)) demonstrate the importance of HPCs, especially OH-PCBs, as plasma-associated contaminants. OH-PCBs are most likely metabolites of PCBs, and 4-OH-HpCS is a likely metabolite of OCS. Our findings indicate that metabolic biotransformation is a factor in the bioaccumulation, pharmacokinetics, and fate of OCS and highly chlorinated PCB congeners that are generally more recalcitrant in fish. Target tissue exposure to circulating OH-PCBs was variable, and thus potential OH-PCB-mediated toxicological activity and effects (e.g., endocrine-related) and health risks are different among the fish species.
authors.affiliation: Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Li
authors.forename: Ken G
authors.initials: KG
authors.lastname: Drouillard
authors.forename: Erin
authors.initials: E
authors.lastname: Bennett
authors.forename: G Douglas
authors.initials: GD
authors.lastname: Haffner
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Letcher
mesh_terms: D000818:Animals; D001711:Biotransformation; D004784:Environmental Monitoring; D005399:Fishes; D020387:Food Chain; D006114:Great Lakes Region; D006801:Humans; D007306:Insecticides / Q000378:metabolism / Q000493:pharmacokinetics*; D010636:Phenols / Q000378:metabolism / Q000493:pharmacokinetics*; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000493:pharmacokinetics*; D011634:Public Health; D018570:Risk Assessment; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D007306:Insecticides; D010636:Phenols; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls