title: Tetraacyldiborates: selective and efficient acylation reagents suitable for multiple parallel synthetic applications.
abstract: Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable.
authors.affiliation: Department of Medicinal Chemistry, Kansas University, Lawrence, KS 66045-2506, USA.
authors.forename: Elmer J
authors.initials: EJ
authors.lastname: Gentry
authors.forename: Hanumaiah
authors.initials: H
authors.lastname: Telikepalli
authors.forename: Pusuluri
authors.initials: P
authors.lastname: Srinivas
authors.forename: Lester A
authors.initials: LA
authors.lastname: Mitscher
mesh_terms: D000215:Acylation; D000438:Alcohols / Q000138:chemical synthesis; D000588:Amines / Q000138:chemical synthesis; D001881:Borates / Q000138:chemical synthesis*; D002614:Chelating Agents / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis
chemical_list: D000438:Alcohols; D000588:Amines; D001881:Borates; D002614:Chelating Agents; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds