title: Expression of matrix metalloproteinases 7 and 2 in human renal cell carcinoma.
abstract: Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several malignant tumors in human. Especially so MMP-7, as it is mainly produced by the cancer cell itself. However, the expression of MMP-7 in renal cell carcinoma (RCC) has not been investigated. We examined expressions of MMP-7 and MMP-2 in RCC, and compared them with the clinicopathological characteristics in RCC. Tumor samples from 20 patients with RCC, who had surgery performed at Osaka City University Medical School Hospital, were immunohistochemically stained. Expression of MMP-2 was significantly stronger in advanced stage and in high grade tumors than in low stage and low grade tumors. MMP-7 was also expressed in RCCs, with its expression especially and significantly stronger in high grade than in low grade tumors (p=0.004). However, there was no significant difference of MMP-7 expression between advanced and low stages (p=0.1859). This increased expression of MMP-7 in high grade RCC might be associated with tumor invasion and metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. sumi-toshi@med.osaka-cu.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sumi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yooji
authors.initials: Y
authors.lastname: Hyun
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Yasui
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Eri
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sugimura
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kawashima
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishiko
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000201:enzymology* / Q000556:secondary* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2