title: Efficient synthesis of a configurationally stable l-serinal derivative.
abstract: An efficient synthesis of a configurationally stable l-serinal derivative 8 was achieved using an N-hydroxymethyl group in about 50% overall yield in four steps from l-serine. Not more than 1% racemization was observed during the preparation of 8. Its enantiomeric integrity was maintained for at least 15 days at room temperature, and it was stable on silica gel. The orthogonal protective groups of 8 would make it a useful chiral synthon.
authors.affiliation: School of Chemical Engineering, College of Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Yoo
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Oh
authors.forename: Dong-Whal
authors.initials: DW
authors.lastname: Lee
authors.forename: Young Gyu
authors.initials: YG
authors.lastname: Kim