Acquired T-helper 1 lymphocyte anergy following infection with Mycobacterium ulcerans.
We describe a patient with acquired T-helper lymphocyte anergy to mycobacteria following infection with Mycobacterium ulcerans. Before infection, the patient's peripheral blood mononuclear cells responded to in vitro stimulation with M. ulcerans by producing Th1 cytokines, but, after she developed an ulcer, the response was shifted toward production of Th2 cytokines. Immunomodulatory therapy may be an effective intervention for Buruli ulcer.
Gooding
Travis M
TM
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
Kemp
Andrew S
AS
Robins-Browne
Roy M
RM
Smith
May
M
Johnson
Paul D R
PD
D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology*; D019911:Mycobacterium ulcerans / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines