title: Wilson's disease and hepatic transplantation.
abstract: To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson's disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in 18 patients with Wilson's disease were observed, and those changes were followed up in 20 non-operative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than penicillamine in the treatment of Wilson's disease.
authors.affiliation: Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Tang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xue
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D002648:Child; D003300:Copper / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D016896:Treatment Outcome
chemical_list: D003300:Copper; D002570:Ceruloplasmin