Unusual hepatic tumor with features of mesenchymal hamartoma and congenital solitary nonparasitic cyst.
We report a hepatic tumor in an adolescent that does not fit into any of the described categories of liver tumors. The patient presented with hepatomegaly, abdominal pain, and normal liver function test; the tumor was cystic in imaging studies. The resected specimen, result of a partial hepatectomy, measured 21 cm and was multicystic with solid areas. Microscopically, the cysts were lined by a mucous-producing or intestinal-type epithelium, associated with smooth muscle and small mucous-producing glands. The solid component contained fibrous and adipose tissue, smooth muscle and thick-walled vessels. Aneuploidy was demonstrated by flow cytometry. We interpreted the tumor as having features of a mesenchymal hamartoma and congenital solitary nonparasitic cyst. It is conceivable that the lesions originated with small peribiliary glands with dilatation and intestinal metaplasia.
Azar
Georgia M
GM
Department of Pathology, New York University Medical Center, New York, NY, USA.
Kutin
N
N
Kahn
Ellen
E
D000293:Adolescent; D000782:Aneuploidy; D015415:Biomarkers / Q000032:analysis; D003560:Cysts / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D005434:Flow Cytometry; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008107:Liver Diseases / Q000151:congenital / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009093:Mucus / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D015415:Biomarkers