[Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women].
OBJECTIVE
To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.


METHODS
The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.


RESULTS
In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14.29% and 0, respectively (P>0.05).


CONCLUSIONS
Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
Chen
Jun
J
Department of Endocrinology, the Second Teaching Hospital of Chongqing Medical University, Chongqing, 400010 P. R. China. Chen_96938@163.com
Zhang
Liping
L
Qiu
Junfeng
J
Peng
Hui
H
Deng
Zhongliang
Z
Wang
Yujun
Y
Yan
Zhongde
Z
D004247:DNA / Q000235:genetics / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; D004247:DNA; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific