title: Effect of Eurycoma longifolia Jack on libido in middle-aged male rats.
abstract: The effect of increasing doses of various fractions of Eurycoma longifolia Jack extracts on libido was examined in middle-aged male rats. The results showed that a high dose (800 mg/kg) of all E. longifolia Jack extracts significantly increased mount frequency (MF) (P < 0.05) over that of untreated controls, but had no effect on the frequency of intromission or ejaculation. Methanol, chloroform, water, and butanol fractions exhibited MF of 2.5 +/- 0.1, 2.6 +/- 0.3, 2.5 +/- 0.1 and 2.6 +/- 0.2, respectively, in adult, middle-aged male rats, and retired breeders versus 2.3 +/- 0.1 in untreated controls. This translated to a minor increase in MF of 8.7%, 13.0%, 8.7%, and 13.0% for these fractions, respectively, during the 20-minute observation period. The results of this study show that E. longifolia Jack extracts can increase libido in middle-aged male rats.
authors.affiliation: School of Pharmaceutical Sciences, University Science Malaysia, Minden, Penang, Malaysia. hhang@usm.my
authors.forename: Hooi Hoon
authors.initials: HH
authors.lastname: Ang
authors.forename: Kheng Leng
authors.initials: KL
authors.lastname: Lee
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D035701:Eurycoma / Q000737:chemistry*; D007989:Libido / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents; D013268:Stimulation, Chemical
chemical_list: D010936:Plant Extracts; D012997:Solvents