Mitosis through the microscope: advances in seeing inside live dividing cells.
The most visually spectacular events in the life of a cell occur when it divides. This is especially true in higher eukaryotes, where the size and geometry of cells allow the division process to be followed through a microscope with considerable clarity. In these organisms, the membrane surrounding the nucleus breaks down after the replicated DNA has condensed to form discrete chromosomes. Several new structures are then assembled to separate the chromosomes and partition the cytoplasm into two separate cells.
Rieder
Conly L
CL
Lab of Cell Regulation, Division of Molecular Medicine, Wadsworth Center, Albany, NY 12201-0509, USA. rieder@wadsworth.org
Khodjakov
Alexey
A
D000818:Animals; D002455:Cell Division; D018385:Centrosome / Q000378:metabolism / Q000648:ultrastructure; D002875:Chromosomes / Q000378:metabolism* / Q000648:ultrastructure; D036681:Fluorescence Recovery After Photobleaching; D031541:Fluorescence Resonance Energy Transfer; D018386:Kinetochores / Q000378:metabolism / Q000648:ultrastructure; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D008868:Microtubule Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D008938:Mitosis; D008941:Spindle Apparatus / Q000378:metabolism* / Q000648:ultrastructure
D008868:Microtubule Proteins