title: Dietary lipids alter the effect of steroids on transport of glucose after intestinal resection: Part II. Signalling of the response.
abstract: OBJECTIVE
  Glucocorticosteroids alter the function of the intestine. Budesonide (Bud) increases the jejunal D-glucose uptake, and this effect is prevented through a polyunsaturated fatty acid (PUFA) diet. This study was undertaken to assess the possible signalling effect of budesonide, prednisone (Pred), or dexamethasone (Dex) in animals with a 50% intestinal resection and fed chow or a diet enriched with saturated (SFA) or polyunsaturated fatty acids.
  
  
  METHODS
  Northern blots were performed.
  
  
  RESULTS
  Steroids reduced the jejunal but not the ileal expression of proglucagon. Ornithine decarboxylase (ODC) expression was reduced in the jejunum.
  
  
  CONCLUSIONS
  c-jun, ODC, and proglucagon may be involved in the adaptive response that occurs with steroids and variations in dietary lipids after intestinal resection.
authors.affiliation: Nutrition and Metabolism Research Group, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Aducio L
authors.initials: AL
authors.lastname: Thiesen
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Tappenden
authors.forename: Mike I
authors.initials: MI
authors.lastname: McBurney
authors.forename: M Thomas
authors.initials: MT
authors.lastname: Clandinin
authors.forename: Monika
authors.initials: M
authors.lastname: Keelan
authors.forename: Ben K
authors.initials: BK
authors.lastname: Thomson
authors.forename: Gary E
authors.initials: GE
authors.lastname: Wild
authors.forename: Alan B
authors.initials: AB
authors.lastname: Thomson
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D019819:Budesonide / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D016758:Genes, jun / Q000187:drug effects; D005934:Glucagon / Q000096:biosynthesis / Q000235:genetics; D005938:Glucocorticoids / Q000494:pharmacology*; D005947:Glucose / Q000493:pharmacokinetics*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism / Q000601:surgery*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000187:drug effects; D011241:Prednisone / Q000494:pharmacology; D052336:Proglucagon; D011498:Protein Precursors / Q000096:biosynthesis / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D005938:Glucocorticoids; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D016755:Proto-Oncogene Proteins c-jun; C504581:Stx2 protein, rat; D019819:Budesonide; D052336:Proglucagon; D003907:Dexamethasone; D005934:Glucagon; D009955:Ornithine Decarboxylase; D005947:Glucose; D011241:Prednisone