title: Reconstruction with autologous pasteurized whole knee joint II: application for osteosarcoma of the proximal tibia.
abstract: Reconstruction of the knee joint for osteosarcoma of the proximal tibia is a formidable challenge. Here we present two patients whose knees were reconstructed with autologous grafts of whole-knee joint treated by extracorporeal pasteurization. Incorporation at the junction between host and pasteurized bone was evident. On the other hand, direct reattachment of the patellar tendon to the pasteurized tibia was not successful in case 1. In case 2, in contrast, the patella was divided followed by successful reconstruction at the osseous site. Avoiding reattachment of pasteurized ligamentous structure is recommended. The operation protocol is not ideal but so far may be superior to other reconstruction procedures because there are many fundamental complications such as low long-term survival of a massive prosthesis and the lethal risk of transfection (e.g. human immunodeficiency virus); moreover, immunological responses of the allograft can be avoided.
authors.affiliation: Department of Orthopedic Surgery, Gunma University Faculty of Medicine, 3-39-15 Showa, Maebashi 371-8511, Japan.
authors.forename: Hideomi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Adel Refaat
authors.initials: AR
authors.lastname: Ahmed
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shinozaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yanagawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Terauchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Takagishi
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006979:Hyperthermia, Induced; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D012516:Osteosarcoma / Q000473:pathology / Q000601:surgery*; D019651:Plastic Surgery Procedures; D013977:Tibia