Three new quassinoids, ailantinol E, F, and G, from Ailanthus altissima.
Three new quassinoids, ailantinol E (1), ailantinol F (2), and ailantinol G (3), and related compounds were isolated from Ailanthus altissima grown in Taiwan. Their structures were elucidated from spectral evidence. Each new quassinoid was evaluated for its antitumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The new quassinoids were found to show potent activity without showing any cytotoxicity. The screening for inhibitors against nitric oxide donor action was also conducted using the new quassinoids and some standard samples.
Tamura
Sadaaki
S
Faculty of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan.
Fukamiya
Narihiko
N
Okano
Masayoshi
M
Koyama
Junko
J
Koike
Kazuo
K
Tokuda
Harukuni
H
Aoi
Wataru
W
Takayasu
Junko
J
Kuchide
Masashi
M
Nishino
Hoyoku
H
D032268:Ailanthus; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018547:Plant Stems; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010936:Plant Extracts; D036702:Quassins; C478581:ailantinol E; C478580:ailantinol F; C478579:ailantinol G