[Estrogen and bone metabolism in man].
In males, androgen can be aromatized into estrogen by aromatase. Estrogen receptors were shown to be present in male-derived human osteoblasts. For males bone is an important target tissue of estrogen. It was demonstrated that deficiency of estrogen or mutation of estrogen receptor gene in males could lead to osteopenia, even osteoporosis. Estrogens are required for the pubertal growth of bone and play important roles in maintenance of bone mass in males.
Gan
Wei-Dong
WD
Department of Urology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu 210008, China.
Dai
Yu-Tian
YT
Sun
Ze-Yu
ZY
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D008297:Male; D011627:Puberty / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*
D000728:Androgens; D004967:Estrogens; D011960:Receptors, Estrogen; D001141:Aromatase