title: Children of parents with obsessive-compulsive disorder -- a 2-year follow-up study.
abstract: OBJECTIVE
  To examine the association between parental obsessive-compulsive disorder (OCD) and emotional and behavioural disorders in offspring.
  
  
  METHODS
  Demographic, clinical, and diagnostic data were collected from parents with OCD, control subjects, and their respective offspring. Offspring were reassessed at a 2-year follow-up.
  
  
  RESULTS
  Probands with OCD and controls were relatively well matched for age, gender, race, educational rating, and marital status. Offspring of OCD probands were at greater risk than offspring of controls for dimensionally measured anxiety, depression, somatization, and social problems. OCD offspring were significantly more likely than control offspring to have lifetime overanxious disorder, separation anxiety disorder, OCD, or 'any anxiety disorder'. Female gender in the parent with OCD, evidence of family dysfunction, and high symptom levels in offspring were predictive of broadly defined OCD at follow-up.
  
  
  CONCLUSIONS
  Children having a parent with OCD are more likely than control offspring to have social, emotional, and behavioural disorders.
authors.affiliation: Department of Psychiatry, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242-1000, USA. donald-black@uiowa.edu
authors.forename: D W
authors.initials: DW
authors.lastname: Black
authors.forename: G R
authors.initials: GR
authors.lastname: Gaffney
authors.forename: S
authors.initials: S
authors.lastname: Schlosser
authors.forename: J
authors.initials: J
authors.lastname: Gabel
mesh_terms: D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000209:etiology* / Q000523:psychology; D001008:Anxiety Disorders / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D010287:Parent-Child Relations; D012307:Risk Factors; D012919:Social Behavior