title: Isolation and characterization of two new antifungal antibiotics from a basidiomycete.
abstract: Two novel antibiotics, Sch 484129 (1) and Sch 484130 (2), were isolated from the fermentation broth of a fungal culture, which was identified as a Basidiomycete. The new antibiotics were obtained by ethyl acetate extraction followed by reversed phase HPLC purification. Structure elucidation of 1 and 2 was accomplished by spectroscopic data analyses. Derivatizations of the major component 1 were performed in order to provide definitive structural information. Both components were identified as glycolipids and displayed antifungal activity against Saccharomyces and Aspergillus strains.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey, USA. min.chu@spcorp.com
authors.forename: Min
authors.initials: M
authors.lastname: Chu
authors.forename: Ronald
authors.initials: R
authors.lastname: Mierzwa
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.forename: Erik
authors.initials: E
authors.lastname: Langsdorf
authors.forename: Martha
authors.initials: M
authors.lastname: Beyazova
authors.forename: Joseph
authors.initials: J
authors.lastname: Terracciano
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Vincent
authors.initials: V
authors.lastname: Gullo
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012440:Saccharomyces / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D006017:Glycolipids; D009005:Monosaccharides; C472759:Sch 484129; C472760:Sch 484130