title: It is true that, when Langerhans cells migrate from the skin to the lymph node, they are transported via lymph vessels.
abstract: BACKGROUND
  Generally, Langerhans cells deliver antigen information from the skin to the draining lymph nodes via lymph vessels.
  
  
  METHODS
  By immunohistopathology, we investigated the delivery route of Langerhans cells in human skin using CD1a and S-100 protein antibodies.
  
  
  RESULTS
  We noted CD1a- and S-100-positive Langerhans cells in the lymph vessels of the dermis. These were shaped like dendritic cells and presented with some lymphocytes, melanophages, melanin granules and lymph in the same vessels.
  
  
  CONCLUSIONS
  These observations support the concept that Langerhans cells deliver antigen peptides to regional lymph nodes via afferent lymph vessels.
authors.affiliation: Division of Pathological Cytology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan. ksugiura@med.nagoya-u.ac.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Sugiura
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Shamoto
authors.forename: Nao
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Shinzato
authors.forename: Akiko
authors.initials: A
authors.lastname: Osada
authors.forename: Mariko
authors.initials: M
authors.lastname: Sugiura
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Hayakawa
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kato
mesh_terms: D018949:Antigens, CD1 / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*; D012867:Skin / Q000166:cytology / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D009418:S100 Proteins