[Mechanism of action of ACE-inhibitors and angiotensin receptor antagonists in diabetic nephropathy. Recent insights].
Hyperglycemia predisposes to organ damages, particularly to nephropathy, via various and complex interrelated pathogenetic mechanisms, that is the well reported proteic glycosylation, vasoactive substances production, oxidative stress, and in particular renin-angiotensin system modulation. Genetic variability plays an important role in determining the response of patients with diabetes on these mechanisms. The analysis of physiopathogenic mechanisms underlying diabetic nephropathy brings evidence that ACE-inhibitors and angiotensin II antagonists have a protective effect not limited to the blood pressure-lowering effect.
Martinelli
Lucia
L
Cattedra di Medicina Interna, Università, Udine.
Ceriello
Antonio
A
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents