title: [Assessment of nasopharyngeal carcinoma risk by EB virus antibody profile].
abstract: OBJECTIVE
  To evaluate the risk of nasopharyngeal carcinoma (NPC) through EB virus antibody profile by enzyme linked immunosorbent assay (ELISA).
  
  
  METHODS
  EBNA 1/IgA, EBNA 1/IgG and zta/IgG by ELISA and VCA/IgA by immmunoenzymatic method were detected in 121 NPC patients and 332 healthy subjects (HS) in the Pearl river estuary.
  
  
  RESULTS
  The sensitivity rates were 85%, 83% and 79% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was the highest 92%. The specificity rates were 86%, 86% and 80% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was also the highest 93%. According to the level of odds ratio, nasopharyngeal carcinoma risk could be divided into 3 groups: low, moderate and high-risk groups. 93% of HS had low risk of NPC with the odds ratio 0.0 to 0.3. 0.4% of HS had high risk of NPC with the odds ratio of 137.9%.
  
  
  CONCLUSIONS
  ELISA is more objective than the traditional immunoenzymatic method in the detection and diagnosis of NPC. The combination of EBNA 1/IgA, EBNA 1/IgG and zta/IgG is able to evaluate the risk of NPC.
authors.affiliation: Cancer Institute, Zhong Shan City, Zhongshan 528403, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Cheng
authors.forename: Guoxiong
authors.initials: G
authors.lastname: Chen
authors.forename: Honglin
authors.initials: H
authors.lastname: Chen
authors.forename: Ruixian
authors.initials: R
authors.lastname: Luo
authors.forename: Zibo
authors.initials: Z
authors.lastname: Wu
authors.forename: Yingsi
authors.initials: Y
authors.lastname: Lu
authors.forename: Bojian
authors.initials: B
authors.lastname: Zheng
authors.forename: Mingfang
authors.initials: M
authors.lastname: Ji
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Liang
authors.forename: Xintang
authors.initials: X
authors.lastname: Cen
authors.forename: Dekun
authors.initials: D
authors.lastname: Wang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zong
authors.forename: Wenhan
authors.initials: W
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000821:virology; D012307:Risk Factors
chemical_list: D000914:Antibodies, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; C417029:EBV-encoded nuclear antigen 1