[Expression of p27 protein and cyclinD1 in laryngeal carcinoma].
OBJECTIVE
To find out whether the expression of p27 and cyclin D1 is different in laryngeal squamous cell carcinoma and the edge tissues, and to study the relationship between the expression of p27 and cyclin D1 with the clinic character in patients with laryngeal squamous cell carcinoma.


METHODS
An immunohistochemistry method was used to study the expression of p27 protein and cyclinD1 in 38 laryngeal squamous cell carcinoma and the edge tissues.


RESULTS
The expression of p27 protein and cyclin D1 was significantly different between the laryngeal carcinoma and the edge tissue. Low expression of p27 and over expression of cyclinD1 was associated with the liability of lymph node metastasis and the poor prognosis for patient with laryngeal squamous cell carcinoma. An interesting observation was that the inverse expression between p27 and cyclinD1 might play an important role in laryngeal squamous cell carcinoma.


CONCLUSIONS
p27 protein and cyclinD1 in laryngeal carcinoma is apparently a significance predictor of survival.
Zhang
Lihong
L
Department of Otorhinolaryngology, People's Hospital of Peking University, Beijing 100044.
Xu
Yi
Y
Ge
Yi
Y
Yu
Youzhi
Y
Yu
Lisheng
L
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009124:Muscle Proteins; D011379:Prognosis
D008840:Microfilament Proteins; D009124:Muscle Proteins; C058992:Tagln protein, mouse; D019938:Cyclin D1