title: Evaluation of antibiotic use in a hospital with an antibiotic restriction policy.
abstract: The study was designed to evaluate rational antibiotic use in relation to diagnosis and bacteriological findings. All hospitalized patients who received antibiotics were evaluated by a cross-sectional study. Of the 713 patients hospitalized, 281 (39.4%) patients received 377 antibiotics. Among 30 different antibiotics the most frequently requested were first generation cephalosporins (19.9%), ampicillin-sulbactam (19.1%) and aminoglycosides (11.7%). Antibiotic use was appropriate in 64.2% of antibiotic requests. In analysis of appropriate use, a request after an infectious diseases consultation was a frequent reason (OR=14, P<0.001, CI=0.02-0.24). Antibiotics requested in conjunction with susceptibility results were found to be more appropriate than those ordered empirically (OR=4.5, P=0.017, CI=0.06-0.76). Inappropriate antibiotic use was significantly higher among unrestricted antibiotics than restricted ones (P<0.001). Irrational antibiotic use was high for unrestricted antibiotics. Additional interventions such as postgraduate training programmes and elaboration of local guidelines could be beneficial.
authors.affiliation: Ankara Numune Education and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey. aerbay@superonline.com
authors.forename: Ayşe
authors.initials: A
authors.lastname: Erbay
authors.forename: Aylin
authors.initials: A
authors.lastname: Colpan
authors.forename: Hürrem
authors.initials: H
authors.lastname: Bodur
authors.forename: Mustafa A
authors.initials: MA
authors.lastname: Cevik
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Samore
authors.forename: Onder
authors.initials: O
authors.lastname: Ergönül
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000517:prevention & control; D003430:Cross-Sectional Studies; D004363:Drug Utilization / Q000331:legislation & jurisprudence / Q000592:standards; D005069:Evaluation Studies as Topic; D005260:Female; D019983:Guideline Adherence; D006761:Hospitals; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic
chemical_list: D000900:Anti-Bacterial Agents