Efficient synthesis of a configurationally stable l-serinal derivative.
An efficient synthesis of a configurationally stable l-serinal derivative 8 was achieved using an N-hydroxymethyl group in about 50% overall yield in four steps from l-serine. Not more than 1% racemization was observed during the preparation of 8. Its enantiomeric integrity was maintained for at least 15 days at room temperature, and it was stable on silica gel. The orthogonal protective groups of 8 would make it a useful chiral synthon.
Yoo
Dongwon
D
School of Chemical Engineering, College of Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Oh
Joon Seok
JS
Lee
Dong-Whal
DW
Kim
Young Gyu
YG