An unusual native tricuspid valve endocarditis caused by Candida colliculosa.
Candida colliculosa, which grew in blood cultures of a 71-year-old retired man with fever of unknown origin that had lasted for 7 months, in conjunction with transthoracic echocardiography, demonstrating a 20-mm vegetation, superior to the tricuspid valve, herniating into the right atrial cavity. The finding led to the diagnosis of fungal endocarditis. Fluconazole, 600 mg daily, was commenced for 8 days; followed by amphotericin B, 1 mg/kg daily. On the fourth day of the amphotericin B treatment, the patient underwent replacement of the infected tricuspid valve. Even though the initial postoperative period was relatively uncomplicated, the patient died after a gross aspiration on the 67th day of his hospital stay, despite aggressive cardiovascular support and antimicrobial therapy. This is the first report of a native tricuspid valve fungal endocarditis due to C. colliculosa or Torulaspora delbrueckii, which is not known to be a human pathogen.
Kaygusuz
I
I
Department of Medicine, Marmara University School of Medicine and Marmara Universitesi Hastanesi, Infeksiyon Hastaliklari ABD, 81090 Altunizade, Istanbul, Turkey.
Mulazimoglu
L
L
Cerikcioglu
N
N
Toprak
A
A
Oktay
A
A
Korten
V
V
D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D004696:Endocarditis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D014261:Tricuspid Valve / Q000382:microbiology*
D000666:Amphotericin B; D015725:Fluconazole