Expression of multidrug resistance protein 4 and 5 in the porcine coronary and pulmonary arteries.
Guanosine 3',5'-cyclic monophosphate (cGMP) has an important role in regulating vascular smooth muscle tone. We examined whether mRNA for multidrug resistance protein (MRP) 4 and MRP5, which were recently identified as ATP-dependent export pumps for cyclic nucleotides, is expressed in the porcine coronary and pulmonary arteries. The results showed that both arteries express mRNA for MRP4 and MRP5, and thus these proteins may be novel targets for the prevention and/or treatment of various cardiovascular diseases.
Mitani
Akiko
A
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Tokyo 108-8641, Minato-ku, Japan.
Nakahara
Tsutomu
T
Sakamoto
Kenji
K
Ishii
Kunio
K
D000818:Animals; D001692:Biological Transport; D003331:Coronary Vessels / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism; D018432:Drug Resistance, Multiple; D015870:Gene Expression; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis* / Q000235:genetics; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D011651:Pulmonary Artery / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D013552:Swine
D006152:Cyclic GMP; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012333:RNA, Messenger