Azalide 3,6-ketals: antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues.
Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.
Sakya
Subas M
SM
Veterinary Medicine Research and Development, Pfizer Inc, Groton, CT 06340, USA. sakyas@groton.pfizer.com
Bertinato
Peter
P
Pratt
Bryan
B
Suarez-Contreras
Melani
M
Lundy
Kristin M
KM
Minich
Martha L
ML
Cheng
Hengmiao
H
Ziegler
Carl B
CB
Kamicker
Barbara J
BJ
Hayashi
Shigeru F
SF
Santoro
Sheryl L
SL
George
David M
DM
Bertsche
Camilla D
CD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008414:Mastitis, Bovine / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D016979:Pasteurella multocida / Q000187:drug effects; D012766:Pasteurellosis, Pneumonic / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D007987:Gonadotropin-Releasing Hormone