title: Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.
abstract: BACKGROUND
  Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.
  
  
  RESULTS
  A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.
  
  
  CONCLUSIONS
  The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, USA. heckbert@u.washington.edu
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.forename: Lucia A
authors.initials: LA
authors.lastname: Hindorff
authors.forename: Karen L
authors.initials: KL
authors.lastname: Edwards
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.forename: Thomas
authors.initials: T
authors.lastname: Lumley
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Tang
authors.forename: J Peter
authors.initials: JP
authors.lastname: Durda
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kronmal
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
mesh_terms: D000368:Aged; D000483:Alleles; D044383:Black People / Q000235:genetics*; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics; D005500:Follow-Up Studies; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D018570:Risk Assessment; D020521:Stroke / Q000453:epidemiology / Q000235:genetics; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics*; D001741:Black or African American
chemical_list: D018343:Receptors, Adrenergic, beta-2