title: Synthesis and cytotoxic evaluation of novel thiazolocarbazoles.
abstract: Novel thiazolocarbazole derivatives 4 and 5 have been synthesized via the corresponding imino-1,2,3-dithiazoles 3. In vitro antitumor activity of these polyheterocyclic compounds was studied and the results show that 2-cyano derivatives exhibit a medium in vitro antiproliferative effect.
authors.affiliation: Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, F-45067 Orleans cedex 2, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Lamazzi
authors.forename: Hadjila
authors.initials: H
authors.lastname: Chabane
authors.forename: Valerie
authors.initials: V
authors.lastname: Thiery
authors.forename: Alain
authors.initials: A
authors.lastname: Pierre
authors.forename: Stephane
authors.initials: S
authors.lastname: Leonce
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: Pierre
authors.initials: P
authors.lastname: Renard
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
authors.forename: Thierry
authors.initials: T
authors.lastname: Besson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007097:Imines / Q000138:chemical synthesis; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D007097:Imines; D013844:Thiazoles