The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I.
The tetranucleotide repeat locus C2_4_4 situated in the HLA class I region (6p21.3) and the HLA-ABC specificities were investigated in an Austrian population sample of 240 unrelated Caucasoid individuals. The analysis of the linkage disequilibrium between C2_4_4 and HLA class I showed several significant values, especially when factors coded for by so-called "superhaplotypes" were considered; such linkage disequilibria are of importance for the practical use of HLA coded short tandem repeats.
Stadlbacher
Simone
S
University of Vienna, Division of Blood Group Serology, Waehringer Guertel 18-20, A-1090 Wien, Austria.
Dauber
Eva-Maria
EM
Wenda
Sabine
S
Glock
Barbara
B
Hafner
Maria
M
Körmöczi
Günther F
GF
Mayr
Wolfgang R
WR
D001317:Austria; D005787:Gene Frequency; D005805:Genes, MHC Class I; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic