title: Microabrasion versus microabrasion followed by 15% trichloroacetic acid for treatment of cutaneous hyperpigmentations in adult females.
abstract: BACKGROUND
  Cutaneous hyperpigmentations are common skin disorders that are often refractory to currently available treatments.
  
  
  OBJECTIVE
  To evaluate the efficacy of microabrasion alone or microabrasion with 15% trichloroacetic acid (TCA) for treatment of cutaneous hyperpigmentations.
  
  
  METHODS
  Twenty female patients were treated with microabrasion alone every 2 weeks (group 1), and 20 female patients were treated with microabrasion and application of 15% TCA every 3 weeks (group 2). All patients underwent up to eight treatments. The overall duration of treatment ranged from 2 to 4 months.
  
  
  RESULTS
  In group 1, a complete remission was observed in 8 of 20 cases (40%), partial remission in 10 of 20 cases (50%), and no remission in 2 of 20 cases (10%). In group 2, a complete remission was observed in 10 of 20 cases (50%), a partial remission in 8 of 20 cases (40%), and no remission in 2 of 20 cases (10%). No unexpected or serious side effects were observed in either group.
  
  
  CONCLUSIONS
  Microabrasion alone or microabrasion with 15% TCA is an effective, well-tolerated treatment for cutaneous hyperpigmentations.
authors.affiliation: Department of Dermatology, University of L'Aquila, L'Aquila, Italy. peris@univaq.it
authors.forename: Claudia
authors.initials: C
authors.lastname: Cotellessa
authors.forename: Ketty
authors.initials: K
authors.lastname: Peris
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Fargnoli
authors.forename: Cristina
authors.initials: C
authors.lastname: Mordenti
authors.forename: Rita Sparacio
authors.initials: RS
authors.lastname: Giacomello
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
mesh_terms: D000293:Adolescent; D000328:Adult; D003869:Dermabrasion / Q000379:methods*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000628:therapy*; D008875:Middle Aged; D016896:Treatment Outcome; D014238:Trichloroacetic Acid / Q000008:administration & dosage*
chemical_list: D014238:Trichloroacetic Acid