title: Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18.
abstract: A partial genome scan using microsatellite markers was conducted in order to detect quantitative trait loci (QTLs) for 10 fatty acid contents of the backfat in a pig reference population. Two QTLs were found by studying SSC1, SSC13, and SSC18, where QTLs had already been identified for backfat thickness. A QTL was located between marker loci S0113 and SW974 on chromosome 1; this QTL was only significantly detected (P < 0.05) for linoleic acid. The other QTL was discovered between markers S0062 and S0120 on chromosome 18, and its significance only showed (P < 0.05) for myristic acid. The two QTLs mapped to the same location as the backfat thickness QTL. A third of the phenotypic variation was explained for linoleic acid by the QTL on chromosome 1, and a quarter for myristic acid by the QTL on chromosome 18. Further studies on fine mapping and positional comparative candidate gene analyses will be the next step toward a better understanding of the genetic architecture of fatty acid contents.
authors.affiliation: Laboratory of Statistical Genetics, Institute of Environment and Life Science, Hallym University, Chuncheon 200-702, Korea. clee@hallym.ac.kr
authors.forename: Chaeyoung
authors.initials: C
authors.lastname: Lee
authors.forename: Yeonseung
authors.initials: Y
authors.lastname: Chung
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001415:Back; D002874:Chromosome Mapping / Q000662:veterinary*; D003433:Crosses, Genetic; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005544:Forecasting; D008040:Genetic Linkage; D005838:Genotype; D019787:Linoleic Acid / Q000378:metabolism; D008297:Male; D018895:Microsatellite Repeats; D019814:Myristic Acid / Q000378:metabolism; D040641:Quantitative Trait Loci; D013552:Swine / Q000235:genetics*
chemical_list: D005227:Fatty Acids; D019814:Myristic Acid; D019787:Linoleic Acid