[Reactive changes in circulating neutrophilic granulocytes in physiologic and complicated gestational process].
A comparative study of the morpho-functional characteristics of the circulating neutrophils was carried out by the electron microscopy method on women with physiological pregnancy and pregnancy-induced hypertension or EPH gestosis. Some leukocyte reactions were observed, and their intensity depended on the clinical manifestation of the EPH gestosis. In neutrophils there were detected reformation in the nucleus in the form of redistribution of the ratio between heterochromatin and euchromatin, as well as changes in the ultrastructure of nucleolemma. Both an amount of glycogen and initial or azurophil granules in the cytoplasm decreased very much but solubilization of their enzymes in cytosol did not occur. Such degranulation was due to the features of exocytosis which determined an extraleukocytic release of the content from the primary granules. The data obtained evidence that neutrophils are functionally active in the vascular bed and are likely to take part in the humoral regulation of the whole organism.
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A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005089:Exocytosis / Q000502:physiology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009504:Neutrophils / Q000648:ultrastructure*; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy / Q000097:blood* / Q000502:physiology; D011263:Pregnancy Trimester, Third