title: Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
abstract: The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
authors.affiliation: Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Lumin
authors.initials: L
authors.lastname: Cao
authors.forename: Zaojao
authors.initials: Z
authors.lastname: Chen
authors.forename: Wan
authors.initials: W
authors.lastname: Li
authors.forename: Qingling
authors.initials: Q
authors.lastname: Du
authors.forename: Guiping
authors.initials: G
authors.lastname: Chen
mesh_terms: D000328:Adult; D004717:Endometrium / Q000201:enzymology*; D005260:Female; D006801:Humans; D007213:Indomethacin; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D007436:Intrauterine Devices, Medicated / Q000009:adverse effects*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008875:Middle Aged; D014592:Uterine Hemorrhage / Q000209:etiology / Q000517:prevention & control
chemical_list: D020782:Matrix Metalloproteinases; D007213:Indomethacin