Cholinergic denervation in a pure multi-infarct state: observations on CADASIL.
Circumstantial evidence suggests that vascular dementia (VaD) may be associated with cholinergic denervation. The specificity of this association has been difficult to assess because many of the patients are elderly and have the additional cholinergic lesions of aging and AD. A patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) who died at age 36 showed that pure white matter infarcts, similar to those seen in VaD, can cause cortical cholinergic denervation, but in patterns that vary from those seen in AD.
Mesulam
Marsel
M
Cognitive Neurology and Alzheimer's Disease Center and the Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. mmesulam@northwestern.edu
Siddique
Teepu
T
Cohen
Bruce
B
D000110:Acetylcholinesterase / Q000096:biosynthesis; D000328:Adult; D001921:Brain / Q000473:pathology; D002799:Cholinergic Fibers / Q000473:pathology / Q000502:physiology; D003704:Dementia / Q000209:etiology; D015161:Dementia, Multi-Infarct / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D009483:Neuropsychological Tests; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011956:Receptors, Cell Surface; D012016:Reference Values
D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D000110:Acetylcholinesterase