title: Normal mode analysis with simplified models to investigate the global dynamics of biological systems.
abstract: Dynamical properties of macromolecules are increasingly being recognized as significantly contributing to biological functions, including catalysis, regulation of activity, etc. In this review, theoretical approaches to the study of dynamics of biological systems and their application are discussed. In particular, simplified models for the normal mode analysis are described.
authors.affiliation: Department of Molecular Biology (TPC6), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. ftama@scripps.edu
authors.forename: Florence
authors.initials: F
authors.lastname: Tama
mesh_terms: D003627:Data Interpretation, Statistical; D007700:Kinetics; D046911:Macromolecular Substances; D008954:Models, Biological; D008956:Models, Chemical; D020409:Molecular Motor Proteins; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D046911:Macromolecular Substances; D020409:Molecular Motor Proteins