title: Experimental studies on multiple-model predictive control for automated regulation of hemodynamic variables.
abstract: A model-based control methodology was developed for automated regulation of mean arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive drugs. The control algorithm used a multiple-model adaptive approach in a model predictive control framework to account for variability and explicitly handle drug rate constraints. The controller was experimentally evaluated on canines that were pharmacologically altered to exhibit symptoms of hypertension and depressed cardiac output. The controller performed better as compared to experiments on manual regulation of the hemodynamic variables. After the model bank was determined, mean arterial pressure was held within +/- 5 mm Hg 88.9% of the time with a standard deviation of 3.9 mm Hg. The cardiac output was held within +/- 1 l/min 96.1% of the time with a standard deviation of 0.5 l/min. The manual runs maintain mean arterial pressure only 82.3% of the time with a standard deviation of 5 mm Hg, and cardiac output 92.2% of the time with a standard deviation of 0.6 l/min.
authors.affiliation: Aspen Technology, Inc., Houston, TX 77077, USA.
authors.forename: Ramesh R
authors.initials: RR
authors.lastname: Rao
authors.forename: Brian
authors.initials: B
authors.lastname: Aufderheide
authors.forename: B Wayne
authors.initials: BW
authors.lastname: Bequette
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D002303:Cardiac Output, Low / Q000188:drug therapy / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005246:Feedback; D006439:Hemodynamics; D006706:Homeostasis; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D007022:Hypotension / Q000188:drug therapy / Q000503:physiopathology; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008955:Models, Cardiovascular; D010656:Phenylephrine / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013813:Therapy, Computer-Assisted
chemical_list: D010656:Phenylephrine; D004298:Dopamine