title: Azalide 3,6-ketals: antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues.
abstract: Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.
authors.affiliation: Veterinary Medicine Research and Development, Pfizer Inc, Groton, CT 06340, USA. sakyas@groton.pfizer.com
authors.forename: Subas M
authors.initials: SM
authors.lastname: Sakya
authors.forename: Peter
authors.initials: P
authors.lastname: Bertinato
authors.forename: Bryan
authors.initials: B
authors.lastname: Pratt
authors.forename: Melani
authors.initials: M
authors.lastname: Suarez-Contreras
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Lundy
authors.forename: Martha L
authors.initials: ML
authors.lastname: Minich
authors.forename: Hengmiao
authors.initials: H
authors.lastname: Cheng
authors.forename: Carl B
authors.initials: CB
authors.lastname: Ziegler
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Kamicker
authors.forename: Shigeru F
authors.initials: SF
authors.lastname: Hayashi
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: Santoro
authors.forename: David M
authors.initials: DM
authors.lastname: George
authors.forename: Camilla D
authors.initials: CD
authors.lastname: Bertsche
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008414:Mastitis, Bovine / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D016979:Pasteurella multocida / Q000187:drug effects; D012766:Pasteurellosis, Pneumonic / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D007987:Gonadotropin-Releasing Hormone