Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.
Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.
Mori
Yasuko
Y
Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. ymori@micro.med.osaka-u.ac.jp
Yang
Xuwei
X
Akkapaiboon
Pilailuk
P
Okuno
Toshiomi
T
Yamanishi
Koichi
K
D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D016367:Baculoviridae / Q000235:genetics; D002459:Cell Fusion; D002460:Cell Line; D015654:Herpesvirus 6, Human / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008024:Ligands; D051916:Membrane Cofactor Protein; D008561:Membrane Fusion; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism*
D015703:Antigens, CD; C497857:CD46 protein, human; D008024:Ligands; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins; C070917:glycoprotein H, herpesvirus 6