Lower in vivo brain extracellular GABA concentration in diabetic rats during forced swimming.
Diabetic rats are more immobile during the forced-swimming test (FST) and GABAergic drugs reverse this behavior. We investigated if there is in vivo changes of GABA levels of diabetic rats during the FST. In vivo basal striatal GABA levels of streptozotocin diabetic rats are similar to non-diabetic rats. Non-diabetic rats presented a significant increase in GABA levels after the FST while the increase was delayed and lower in diabetic rats. These results suggest that diabetes may change GABA homeostasis and modify behavioral responses in an animal model of depression.
Gomez
Rosane
R
Pharmacology Division, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, R. Sarmento Leite 245, 90050-170 Porto Alegre, Brazil. rgomez@terra.com.br
Vargas
Carmem R
CR
Wajner
Moacir
M
Barros
Helena M T
HM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001522:Behavior, Animal; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D017551:Microdialysis / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005680:gamma-Aminobutyric Acid; D013311:Streptozocin