title: Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells--an immuno electron microscopic study.
abstract: Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known: its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.
authors.affiliation: Department of Histology & Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Seftalioglu
authors.forename: Sema
authors.initials: S
authors.lastname: Karakus
authors.forename: Semra
authors.initials: S
authors.lastname: Dundar
authors.forename: Belgin
authors.initials: B
authors.lastname: Can
authors.forename: Esra
authors.initials: E
authors.lastname: Erdemli
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Irmak
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
authors.forename: Cem
authors.initials: C
authors.lastname: Korkmaz
authors.forename: Fatih
authors.initials: F
authors.lastname: Yazar
authors.forename: Ilkin
authors.initials: I
authors.lastname: Cavusoglu
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism*; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans