title: A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4.
abstract: We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4[29-39]. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4[29-39].
authors.affiliation: Istituto di Biostrutture e Bioimmagini, CNR and Dipartimento di Chimica Biologica, Università Federico II di Napoli, Via Mezzocannone 6, 80134 Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Palladino
authors.forename: Carlo
authors.initials: C
authors.lastname: Pedone
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ragone
authors.forename: Filomena
authors.initials: F
authors.lastname: Rossi
authors.forename: Michele
authors.initials: M
authors.lastname: Saviano
authors.forename: Ettore
authors.initials: E
authors.lastname: Benedetti
mesh_terms: D000818:Animals; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism*; D005453:Fluorescence; D006801:Humans; D010649:Phenylalanine / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism*
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019718:Receptors, CXCR4; D010649:Phenylalanine