Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1.
The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).
Volpert
Olga V
OV
Department of Urology, RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.
Alani
Rhoda M
RM
D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D019700:Thrombospondin 1 / Q000235:genetics / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D019700:Thrombospondin 1; D018631:ras Proteins