title: [Clinical observation of granisetron in preventing postoperative nausea and vomiting following supratentorial craniotomy].
abstract: OBJECTIVE
  To observe the prophylactic effect of granisetron on postoperative nausea and vomiting (PONV) after supratentorial craniotomy.
  
  
  METHODS
  Seventy ASA I-II patients undergoing elective supratentorial craniotomy were randomly and double-bindly divided into two groups: control group (Group C, n = 35) and granisetron group (Group G, n = 35). All the patients received either 0.9% NS (Group C) or granisetron 3 mg (Group G) via intravenous injection. The incidences of postoperative nausea and vomiting were recorded at 24 h, 48 h, 72 h after supratentorial craniotomy.
  
  
  RESULTS
  The incidence of PONV in Group G was lower than that in Group C (25.7% vs 57.1%, P < 0.01). The incidence of server nausea with vomiting or vomiting in Group G was lower than that in Group C (17.2% vs 48.6%, P < 0.01).
  
  
  CONCLUSIONS
  Granisetron can be used effectively and safely to prevent PONV in supratentorial craniotomy.
authors.affiliation: Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Yun-jiao
authors.initials: YJ
authors.lastname: Wang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Cheng
authors.forename: Qu-lain
authors.initials: QL
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000601:surgery; D003399:Craniotomy; D004311:Double-Blind Method; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
chemical_list: D017829:Granisetron; D012702:Serotonin Antagonists