[Expression of beta-amyloid and tau-protein in mastocytes in Alzheimer disease].
With immunochemical assay, the expression of B-amyloid and tau-protein in the mast cells of the stomach and skin was first detected in patients with Alzheimer's disease (AD), which supports the hypothesis that AD is a systemic disease involving different organs and tissues. Verification of expression of two key peptides that participate in the pathogenesis of AD in the samples of extra-brain tissues allows B-amyloid and tau-protein to be regarded as promising markers and mast cells to be considered to the most suitable object for lifetime diagnosis of neurodegenerative diseases.
Kvetnoĭ
I M
IM
Institute of Bioregulation and Gerontology, North-Western Department, Russian Academy of Medical Sciences, 197110, Saint-Petersburg.
Kvetnaia
T V
TV
Riadnova
I Iu
IIu
Fursov
B B
BB
Ernandes-Jago
H
H
Blesa
J R
JR
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism / Q000648:ultrastructure; D012720:Severity of Illness Index; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure; D013270:Stomach / Q000648:ultrastructure; D016875:tau Proteins / Q000096:biosynthesis*
D016229:Amyloid beta-Peptides; D016875:tau Proteins