Aging: new targets, new functions.
The DAF-16 transcription factor controls aging in C. elegans as part of an insulin-like signaling pathway. Identification of a target of DAF-16 has opened a new window into the aging process.
Patterson
Garth I
GI
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. patterson@waksman.rutgers.edu
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D051858:Forkhead Transcription Factors; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; C478038:SCL-1 protein, C elegans; D014157:Transcription Factors; C108831:daf-16 protein, C elegans