Anodic voltammetric assay of lansoprazole and omeprazole on a carbon paste electrode.
The electrochemical oxidations of lansoprazole and omeprazole have been studied at a carbon paste electrode by cyclic and differential-pulse voltammetry in Britton-Robinson buffer solutions (0.04 M; pH 6.0-10.0). The drug produced a single oxidation step. By differential-pulse voltammetry, a linear response was obtained in B-R buffer pH 6.0 in a concentration range from 2.0 x 10(-7) to 5.0 x 10(-5) M for lansoprazole or omeprazole. The detection limits were 1.0 x 10(-8) and 2.5 x 10(-8) M for lansoprazole and omeprazole, respectively. The method was successfully applied for the analysis of omeprazole and lansoprazole in capsules. The results were comparable to those obtained by spectrophotometry.
Radi
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Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002214:Capsules; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000032:analysis*; D011048:Polarography / Q000379:methods; D054328:Proton Pump Inhibitors; D012680:Sensitivity and Specificity
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002214:Capsules; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D009853:Omeprazole