drs (Distantly related sic) gene polymorphisms among emm12-type Streptococcus pyogenes isolates.
Twenty-eight emm12-type Streptococcus pyogenes isolates from patients with invasive and noninvasive infections or from asymptomatic carriers were genetically typed. Sequencing of drs (distantly related sic [streptococcal inhibitor of complement]) genes identified two novel alleles and revealed a polymorphism for drs similar to that of sic. No association was observed between the five different drs alleles and the five restriction patterns of the vir regulon for the isolates studied. These data suggest that drs sequencing may be useful for further differentiation of S. pyogenes isolates with emm12 and identical vir regulon restriction patterns.
Brandt
Claudia M
CM
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, 52057 Aachen, Germany. claudia.brandt@em.uni-frankfurt.de
Haase
Gerhard
G
Spellerberg
Barbara
B
Holland
Regina
R
Lütticken
Rudolf
R
D000483:Alleles; D000595:Amino Acid Sequence; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015373:Bacterial Typing Techniques; D001483:Base Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D002353:Carrier State / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019105:Random Amplified Polymorphic DNA Technique; D018085:Regulon; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C097739:SIC protein, Streptococcus; C014689:streptococcal M protein; C068267:mry protein, Streptococcus pyogenes