title: Demonstration of acid secretion in the gastric pouch through the pentagastrin stimulation test.
abstract: BACKGROUND
  The aim of this study is to determine the relationship of hydrochloric acid secretion in gastric pouch (GP), an orthotopic neobladder using a stomach segment, to gastrin.
  
  
  METHODS
  Pentagastrin (PG) stimulation test (PGST) was applied in 10 patients who had had GP surgery 5-70 months ago, and their urinary pH changes in the next 2 h were observed.
  
  
  RESULTS
  Significant pH decreases (from 6.6 +/- 0.6 to 2.9 +/- 1.0 in the mean) 30-75 min after injection of PG, demonstrating gastrin-triggered acid secretion in GP were observed in all patients. The pH values were normalized in 2 h (6.6 +/- 1.0 in the mean).
  
  
  CONCLUSIONS
  In PGST, urinary pH decreases, demonstrating the close relationship between gastrin release and acid secretion in the GP. Inhibition of gastrin by any means may be useful in keeping the urinary pH on physiological levels.
authors.affiliation: Department of Urology, Medical Faculty, Kocaeli University, Kocaeli, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Acar
authors.forename: W
authors.initials: W
authors.lastname: Schwizer
authors.forename: D
authors.initials: D
authors.lastname: Hauri
mesh_terms: D000368:Aged; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin; D013270:Stomach / Q000601:surgery*; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D016476:Urinary Reservoirs, Continent
chemical_list: D010418:Pentagastrin