Insulin and the blood-brain barrier.
Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.
Woods
Stephen C
SC
Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA. steve.woods@psychiatry.uc.edu
Seeley
Randy J
RJ
Baskin
Denis G
DG
Schwartz
Michael W
MW
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology*
D007328:Insulin