title: Atherothrombosis, inflammation, and diabetes.
abstract: Diabetes represents a major cause of cardiovascular morbidity and mortality in developed countries, and atherothrombosis accounts for most deaths among diabetics. Recent evidence has reliably shown the relevant etiopathogenetic role of inflammation in atherothrombotic disease. This review summarizes and discusses the possible synergistic effects of diabetes and inflammation in promoting atherothrombosis and its complications, as well as potential avenues for diagnostic, preventive, and therapeutic benefits in the modulation of inflammatory mechanisms in diabetic atherothrombotic disease.
authors.affiliation: Institute of Cardiology, Catholic University, Rome, Italy.
authors.forename: Giuseppe G L
authors.initials: GG
authors.lastname: Biondi-Zoccai
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liuzzo
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Biasucci
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014157:Transcription Factors