The rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastases.
Randomized trials have established the efficacy of focal treatment (either stereotactic radiosurgery or conventional surgery) for single brain metastases. In the past, adjuvant whole brain radiation therapy (WBRT) was routinely given with focal therapy. Recently, the utility of adjuvant WBRT has been called into question. This paper examines the scientific evidence and the arguments, pro and con, concerning the use of adjuvant WBRT in association with stereotactic radiosurgery or conventional surgery.
Patchell
Roy A
RA
Neurosurgery Division, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA. Rpatchell@aol.com
Regine
William F
WF
D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003704:Dementia / Q000209:etiology; D006801:Humans; D011878:Radiotherapy / Q000379:methods*; D018714:Radiotherapy, Adjuvant; D011897:Random Allocation; D016879:Salvage Therapy; D013997:Time Factors; D016896:Treatment Outcome