Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration.
These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.
Lau
Dana
D
School of Optometry and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
Flannery
John
J
D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics* / Q000378:metabolism; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D007150:Immunohistochemistry; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D012162:Retinal Degeneration / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D016222:Fibroblast Growth Factor 2