title: Polymorphism of the codon 129 of the prion protein (PrP) gene and neuropathology of cerebral ageing.
abstract: We studied whether codon 129 polymorphism of the PrP gene modulates the presence of tau- and Abeta-associated lesions among 188 patients over 70 years of age without evidence of dementia. Val allele carriers, either heterozygotes or homozygotes, were more frequently affected by Abeta-associated lesions than non Val allele carriers, whereas there were no differences for tau-positive neurones. Val allele carriers also had more focal and diffuse Abeta deposits. This association was most significant in the highest Braak's stages for neurofibrillary tangles (>/=III). In this group, cases with at least one Val allele had nearly twice as many Abeta-associated lesions. The most affected areas were the entorhinal cortex, TF-TH and the superior temporal cortex, where odds ratios for focal Abeta deposits ranged from 3.5 to 4.6.
authors.affiliation: INSERM U360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière, 75651 Paris Cedex 13, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.forename: Nicole
authors.initials: N
authors.lastname: Helbecque
authors.forename: Véronique
authors.initials: V
authors.lastname: Sazdovitch
authors.forename: Michel
authors.initials: M
authors.lastname: Mohr
authors.forename: Carole
authors.initials: C
authors.lastname: Amant
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Annick
authors.initials: A
authors.lastname: Alpérovitch
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Hauw
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000704:Analysis of Variance; D001921:Brain / Q000378:metabolism / Q000473:pathology; D016009:Chi-Square Distribution; D003062:Codon / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics* / Q000378:metabolism; D014633:Valine / Q000235:genetics; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D003062:Codon; D011328:Prions; D016875:tau Proteins; D008715:Methionine; D014633:Valine