title: Confirmation of cervical neoplasia using a hand-held, lighted magnification device.
abstract: OBJECTIVE
  The objective of this study was to estimate the sensitivity and specificity of visual inspection with acetic acid and magnification (VIAM) using the AviScope device to confirm high-grade cervical intraepithelial neoplasia or carcinoma.
  
  
  METHODS
  VIAM was performed on 142 women aged 18-50 years referred to three colposcopy clinics because of abnormal cervical cytology. Each woman then had a colposcopic examination with cervical biopsy when indicated.
  
  
  RESULTS
  The AviScope device identified 24 of the 40 women who had CIN 2, 3, or carcinoma, yielding a sensitivity of 60.0% (95% CI 43.4, 74.7). The AviScope correctly identified 60 of 87 women negative for dysplasia or cancer, yielding a specificity of 69.0% (95% CI 58.0, 78.2) compared with colposcopy and cervical histology.
  
  
  CONCLUSIONS
  VIAM using the AviScope device was moderately sensitive and specific for the confirmation of high-grade cervical lesions in women referred with abnormal cervical cytology.
authors.affiliation: Program for Appropriate Technology in Health (PATH), Seattle, WA, USA. jwinkler@path.org
authors.forename: J L
authors.initials: JL
authors.lastname: Winkler
authors.forename: V D
authors.initials: VD
authors.lastname: Tsu
authors.forename: A
authors.initials: A
authors.lastname: Bishop
authors.forename: R
authors.initials: R
authors.lastname: Scott
authors.forename: J W
authors.initials: JW
authors.lastname: Sellors
mesh_terms: D019342:Acetic Acid; D000293:Adolescent; D000328:Adult; D003127:Colposcopy; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D008875:Middle Aged; D010808:Physical Examination; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology
chemical_list: D007202:Indicators and Reagents; D019342:Acetic Acid