title: [NO-inhibiting activity of radioprotectors].
abstract: The effect of radioprotectors of different structure on the syntheses of nitric oxide induced by endotoxin in mice was studied. Using ESR-spectroscopy and spin trap techniques, it was shown that compounds of different chemical structure, such as aminothiols, isothiuronium derivatives, thiazolines, indolylalkylamines and others, suppressed the nitric oxide production in a whole body. The analysis of the relevant literature has confirmed the phenomenon described by the authors: radioprotectors show NO-inhibiting activity.
authors.affiliation: Medical Radiology Research Centre, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. noo@mrrc.obninsk.ru
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Proskuriakov
authors.forename: N G
authors.initials: NG
authors.lastname: Kucherenko
authors.forename: M N
authors.initials: MN
authors.lastname: Semenenko
authors.forename: A I
authors.initials: AI
authors.lastname: Trishkina
authors.forename: T P
authors.initials: TP
authors.lastname: Trofimova
authors.forename: L V
authors.initials: LV
authors.lastname: Shteĭn
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Verkhovskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Konopliannikov
authors.forename: A A
authors.initials: AA
authors.lastname: Mandrugin
authors.forename: V M
authors.initials: VM
authors.lastname: Fedoseev
authors.forename: V G
authors.initials: VG
authors.lastname: Skvortsov
mesh_terms: D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004578:Electron Spin Resonance Spectroscopy; D004731:Endotoxins; D008099:Liver / Q000378:metabolism; D008297:Male; D008624:Mercaptoethylamines / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D063086:Organothiophosphates / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019097:Spin Trapping
chemical_list: D004731:Endotoxins; D008624:Mercaptoethylamines; D063086:Organothiophosphates; D011837:Radiation-Protective Agents; D009569:Nitric Oxide; D003545:Cysteine