title: Mechanism of inhibition of novel COX-2 inhibitors.
authors.affiliation: Monsanto/Searle Discovery Research, Chesterfield, Missouri 63198, USA.
authors.forename: James
authors.initials: J
authors.lastname: Gierse
authors.forename: Ravi
authors.initials: R
authors.lastname: Kurumbail
authors.forename: Mark
authors.initials: M
authors.lastname: Walker
authors.forename: Bill
authors.initials: B
authors.lastname: Hood
authors.forename: Joe
authors.initials: J
authors.lastname: Monahan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pawlitz
authors.forename: Rick
authors.initials: R
authors.lastname: Stegeman
authors.forename: Anna
authors.initials: A
authors.lastname: Stevens
authors.forename: Jim
authors.initials: J
authors.lastname: Kiefer
authors.forename: Carol
authors.initials: C
authors.lastname: Koboldt
authors.forename: Kirby
authors.initials: K
authors.lastname: Moreland
authors.forename: Scott
authors.initials: S
authors.lastname: Rowlinson
authors.forename: Larry
authors.initials: L
authors.lastname: Marnett
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pierce
authors.forename: Jeff
authors.initials: J
authors.lastname: Carter
authors.forename: John
authors.initials: J
authors.lastname: Talley
authors.forename: Peter
authors.initials: P
authors.lastname: Isakson
authors.forename: Karen
authors.initials: K
authors.lastname: Seibert
mesh_terms: D000068579:Celecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D007555:Isoxazoles / Q000494:pharmacology; D007700:Kinetics; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000494:pharmacology; D013997:Time Factors; D000096926:Benzenesulfonamides
chemical_list: D000068579:Celecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007555:Isoxazoles; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D011994:Recombinant Proteins; D013449:Sulfonamides; C115461:SC 560; C406224:valdecoxib; D000096926:Benzenesulfonamides; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human