Dual kidneys from marginal adult donors as a source for cadaveric renal transplantation in the United States.
The current organ shortage has led to the utilization of double kidney transplants from marginal adult donors, but outcomes data are limited. The United Network for Organ Sharing registry database was used to compare the outcomes of 403 dual adult kidney transplantations (DKT) and 11,033 single kidney transplantations (SKT) from 1997 to 2000. Graft and patient survival and the effect of multiple risk factors were evaluated. It was found that DKT patients were older, less sensitized, and received grafts from older, more mismatched donors with longer cold ischemia times. There was also a greater percentage of donors with a history of diabetes or hypertension and African-American recipients and donors in the DKT group. Graft survival was inferior in the DKT group, with a 7% lower graft survival rate at 1 yr. There was a higher incidence of primary nonfunction in the DKT group, although the incidence of delayed graft function, early rejection treatment, and graft thrombosis did not differ. Multivariate analysis was used to identify African-American recipient ethnicity and retransplant as risk factors for graft loss. Graft survival was comparable in DKT and SKT with donors over 55 yr of age. DKT resulted in inferior graft outcomes compared with SKT. When compared with SKT with donors over 55 yr of age, DKT resulted in similar graft outcomes. These otherwise discarded kidneys should be cautiously considered as a source of marginal donors.
Bunnapradist
Suphamai
S
Center for Kidney and Kidney-Pancreas Transplantation, Burns-Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. mike.bunnapradist@cshs.org
Gritsch
H Albin
HA
Peng
Alice
A
Jordan
Stanley C
SC
Cho
Yong W
YW
D000328:Adult; D000368:Aged; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D019737:Transplants / Q000592:standards* / Q000600:supply & distribution*; D016896:Treatment Outcome; D014481:United States