title: [Analysis of dot-like hemosiderin spots using brain dock system].
abstract: OBJECTIVE
  Dot-like low intensity spots (a dot-like hemosiderin spot: dotHS) on T2*-weighted MR images (T2*WI), which is regarded as a sensitive method for hemosiderin detection, have been histologically diagnosed as old microbleeds associated with microangiopathies. The clinical significance of the dotHS, however, is still under debate. Therefore, we investigated the factors associated with dotHS.
  
  
  METHODS
  We investigated 209 healthy volunteers in our hospital (sex: 106 males, 103 females; age: 38 to 78 years old, mean age: 56.4 +/- 8.3 years old) using "Brain Dock", a formalized screening system for asymptomatic brain diseases. The Odds ratio (OR) was estimated from multiple logistic regression analyses using the dotHS and variables.
  
  
  RESULTS
  T2*WI demonstrated dotHS in 7.7% of volunteers, and the mean number of dotHS was 0.16 +/- 0.78. The hemosiderin was preferentially deposited in the basal ganglia and thalamus. Age > or = 65 years old (OR: 5.9; 95% confidence interval [CI]: 1.4-25.9; p = 0.02), hypertension (OR: 7.0; 95% CI: 1.4-34.7; p = 0.02), and headache (OR: 5.8; 95% CI: 1.4-24.6; p = 0.02) were all found to be independently associated with dotHS.
  
  
  CONCLUSIONS
  The dotHS was significantly associated with several factors, including age, hypertension and headache.
authors.affiliation: Department of Neurosurgery, Hakodate Municipal Hospital, 1-10-1 Minato-cho, Hakodate, Hokkaido 041-8680, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Horita
authors.forename: Toshio
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Jun
authors.initials: J
authors.lastname: Niwa
authors.forename: Junpei
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: Kei
authors.initials: K
authors.lastname: Miyata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Makabe
authors.forename: Ryo
authors.initials: R
authors.lastname: Moriyama
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Mikami
authors.forename: Manami
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006261:Headache / Q000150:complications; D006485:Hemosiderin / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009098:Multiphasic Screening / Q000379:methods*; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control*
chemical_list: D006485:Hemosiderin