Bronchiolar columnar cell dysplasia--genetic analysis of a novel preneoplastic lesion of peripheral lung.
Atypical adenomatous hyperplasia is the only known precursor lesion of lung adenocarcinomas (ACs) so far. Here, we describe a new dysplastic lesion in the bronchioles of peripheral lung for which we propose the name bronchiolar columnar cell dysplasia (BCCD). Eight of fourteen BCCDs were successfully analyzed by means of comparative genomic hybridization (CGH). The average number of chromosomal aberrations was 2.6 in BCCD and 14.7 in concomitant AC. Among the aberrations were losses of 3p, 9, 13, 14 and gains of 1q, 17, 19q and 20q. Summarizing our data from morphological and genetic analysis, we conclude that BCCD is a preneoplasia of the bronchiolar epithelium and most probably represents an additional precursor lesion of lung adenocarcinomas.
Ullmann
Reinhard
R
Laboratory of Molecular Cytogenetics, Institute of Pathology, Auenbruggerplatz 25, 8036, Graz, Austria.
Bongiovanni
Massimo
M
Halbwedl
Iris
I
Petzmann
Susanna
S
Gogg-Kammerer
Margit
M
Sapino
Anna
A
Papotti
Mauro
M
Bussolati
Gianni
G
Popper
Helmut H
HH
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000473:pathology*; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002869:Chromosome Aberrations; D002875:Chromosomes; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D006824:Hybridization, Genetic; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology