title: A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.
abstract: A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.
authors.affiliation: Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, USA. tangs@smh.toronto.on.ca
authors.forename: Shou-jiang
authors.initials: SJ
authors.lastname: Tang
authors.forename: Sunil
authors.initials: S
authors.lastname: Geevarghese
authors.forename: Sammy
authors.initials: S
authors.lastname: Saab
authors.forename: Dorothy
authors.initials: D
authors.lastname: Martinez
authors.forename: Andre
authors.initials: A
authors.lastname: Van Herle
authors.forename: William D
authors.initials: WD
authors.lastname: Wallace
authors.forename: Galen R
authors.initials: GR
authors.lastname: Cortina
authors.forename: Sarah
authors.initials: S
authors.lastname: Dry
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Busuttil
mesh_terms: D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000556:secondary*; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000556:secondary*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones / Q000097:blood / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D010758:Phosphorus; D002118:Calcium