Neutrality tests using DNA polymorphism from multiple samples.
The polymorphism of a gene or a locus is studied with increasing frequency by multiple laboratories or the same group at different times. Such practice results in polymorphism being revealed by different samples at different regions of the locus. Tests of neutrality have been widely conducted for polymorphism data but commonly used statistical tests cannot be applied directly to such data. This article provides a procedure to conduct a neutrality test and details are given for two commonly used tests. Applying the two new tests to the chemokine-receptor gene (CCR5) in humans, we found that the hypothesis that all mutations are selectively neutral cannot explain the observed pattern of DNA polymorphism.
Li
Haipeng
H
Laboratory of Bioinformatics, Yunnan University, Kunming 650991, People's Republic of China.
Zhang
Yunwu
Y
Zhang
Ya-Ping
YP
Fu
Yun-Xin
YX
D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D015233:Models, Statistical; D011110:Polymorphism, Genetic / Q000235:genetics*; D054399:Receptors, CCR6; D019707:Receptors, Chemokine / Q000235:genetics; D044465:White People / Q000235:genetics
C106311:CCR6 protein, human; D054399:Receptors, CCR6; D019707:Receptors, Chemokine; D004247:DNA