Pharmacotherapy of paediatric epilepsy.
Childhood epilepsy is a common condition, with an annual incidence of approximately 40 of 100,000 in the first decade of life. Although childhood epilepsy is more likely to remit than epilepsy in adults, the developmental and social impact of epilepsy during childhood may extend beyond the childhood years, affecting the individual's potential in cognitive, emotional and socio-economic arenas. The goal of medical management of childhood epilepsy is seizure freedom, with minimal or no adverse effects. Achievement of this goal is crucial in the effort to minimise the long-term disabilities associated with childhood epilepsy. Pharmacotherapy is a cornerstone of management of childhood epilepsy. This review addresses some of the challenges in treatment of epilepsy, which are unique to childhood, and reviews the newer anticonvulsants available and what is known about their role in childhood epilepsy.
Bergin
Ann M
AM
Division of Epilepsy & Clinical Neurophysiology, Department of Neurology, Childrens' Hospital, 300 Longwood Ave, Boston, MA 02115, USA. ann.bergin@tch.harvard.edu
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D004358:Drug Therapy; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D012640:Seizures / Q000517:prevention & control*
D000927:Anticonvulsants