title: Effect of epidural infusion of isobaric 2% lidocaine on spinal cord ganglionic neurons.
abstract: We analyzed morphological and histoenzymologic changes in spinal cord ganglionic neurons of mongrel dogs caused by epidural infusion of isobaric 2% lidocaine. Lidocaine produced no pathological structural and metabolic alterations in the nervous tissue. Both epidural infusion of 0.9% NaCl and lidocaine produced some morphofunctional rearrangements in spinal ganglionic neurons. These alterations were within the limits of physiological norm and probably attested to functional response of the examined nerve tissue structures to epidural infusion.
authors.affiliation: Department of Anesthesiology and Reanimatology, I. P. Pavlov State Medical University, St. Petersburg, Russia. zaytcev@spmu.rssi.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Volchkov
authors.forename: N V
authors.initials: NV
authors.lastname: Boikova
authors.forename: A A
authors.initials: AA
authors.lastname: Zaitsev
authors.forename: V I
authors.initials: VI
authors.lastname: Strashnov
authors.forename: V V
authors.initials: VV
authors.lastname: Tomson
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000767:Anesthesia, Epidural; D000818:Animals; D004285:Dogs; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D006651:Histocytochemistry; D007268:Injections, Epidural; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008833:Microcirculation; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
chemical_list: D000700:Analgesics; D008012:Lidocaine