title: Practical asymmetric synthesis of 1,2-diamines in the 3-aminoazepane series.
abstract: A simple and versatile method for the enantio- and diastereoselective synthesis of mono- or disubstituted 3-aminoazepanes is described. The key step involves a highly regio- and diastereoselective tandem ring-enlargement/alkylation or reduction process. This novel synthetic route provides enantiomerically pure constrained diamines interesting as scaffolds for medicinal chemistry.
authors.affiliation: Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4, av de l'Observatoire, 75270 Paris Cedex 06, France.
authors.forename: S
authors.initials: S
authors.lastname: Cutri
authors.forename: M
authors.initials: M
authors.lastname: Bonin
authors.forename: L
authors.initials: L
authors.lastname: Micouin
authors.forename: H-P
authors.initials: HP
authors.lastname: Husson
authors.forename: A
authors.initials: A
authors.lastname: Chiaroni