title: Portal vein thrombosis after laparoscopy-assisted splenectomy and cholecystectomy.
abstract: A 12-year-old girl underwent laparoscopy-assisted splenectomy and cholecystectomy with removal of her spleen through a small Pfannenstiel incision. She had an unremarkable postoperative course but returned 16 days later because of increasing right-sided abdominal pain. The pain was constant, sharp, and stabbing without radiation. Abdominal examination showed diffuse right upper quadrant and epigastric tenderness without peritoneal irritation. Laboratory test results included white blood cell count, 14.4 x 10(9)/mm3; hemoglobin, 8.5 g/dL; platelets, 1,483,000; and normal values for lipase, amylase, aspartate transaminase, and alanine transaminase. Evaluation with ultrasonography and vessel Doppler studies showed an occlusive thrombus throughout the portal and splenic veins. The patient underwent intravenous heparin anticoagulation therapy. Her symptoms resolved completely over the next 2 days. The patient is currently receiving warfarin and anagrelide as an outpatient (international normalized ratio, 2). There were no long-term complications caused by portal vein thrombosis. This is the first reported case of portal vein thrombosis after laparoscopic splenectomy in the pediatric population.
authors.affiliation: Division of Pediatric Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Jeromy S
authors.initials: JS
authors.lastname: Brink
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Brown
authors.forename: Brian A
authors.initials: BA
authors.lastname: Palmer
authors.forename: Christopher
authors.initials: C
authors.lastname: Moir
authors.forename: David R
authors.initials: DR
authors.lastname: Rodeberg
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000601:surgery; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000150:complications / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000150:complications / Q000601:surgery; D010535:Laparoscopy; D011169:Portal Vein; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D011799:Quinazolines / Q000627:therapeutic use; D013156:Splenectomy; D013162:Splenic Vein; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D011799:Quinazolines; D014859:Warfarin; C021139:anagrelide