title: Erysod, erythrocyte superoxide dismutase preparation: effects on LPO processes and morphological changes in the viscera of rats with burns under conditions of delayed antishock infusion therapy.
abstract: Biochemical and morphological changes in the kidneys, liver, heart, and lungs were studied in rats with deep burns of 20% body surface. Erysod (0.47 mg/kg/day) added to antishock therapy notably reduced the intensity of LPO processes in tissues both in cases when infusion therapy was started immediately (by 8-20% 12 h and by 5-24% 24 h after the injury) and when this therapy was 6 h delayed (by up about 36% after 12 h). This prevented injuries to visceral organs during the acute period of thermal injury and prevented the development of burn disease.
authors.affiliation: St. Petersburg-Tekhnologiya Company, St. Petersburg, Russia. elena@tech.spb.ru
authors.forename: B A
authors.initials: BA
authors.lastname: Paramonov
authors.forename: I V
authors.initials: IV
authors.lastname: Churilova
authors.forename: E V
authors.initials: EV
authors.lastname: Zinov'ev
authors.forename: V Yu
authors.initials: VY
authors.lastname: Chebotarev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002056:Burns / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D004912:Erythrocytes / Q000201:enzymology; D005440:Fluid Therapy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012769:Shock / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D014781:Viscera / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase