title: Effect of Ghrelin on catecholamine secretion in rat pheochromocytoma PC12 cells.
abstract: A novel peptide Ghrelin, found to be a ligand to growth hormone (GH) secretagogue receptor (GHS-R), exeterts to stimulates GH release from pituitary gland. Recently, it has been shown that ghrelin and its receptor are existed in a adrenal ground. At concentrations of 10 nM and over (10 nM, 100 nM, and 1 microM), ghrelin significantly inhibited basal dopamine release by 30, 32 and 34%, respectively (P < 0.05) in PC12 cells, suggesting that ghrelin may be involved in the mechanism of catecholamine regulation in chromaffin cells.
authors.affiliation: Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Nanmoku
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takekoshi
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Ishi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Isobe
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Shibuya
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Okuda
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakai
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D054439:Ghrelin; D016716:PC12 Cells / Q000187:drug effects* / Q000378:metabolism*; D036361:Peptide Hormones / Q000494:pharmacology*; D051381:Rats
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones; D004298:Dopamine