title: Transoesophageal ultrasound applicator for sector-based thermal ablation: first in vivo experiments.
abstract: New curative and palliative treatments must be proposed to respond to the bad long-term prognosis of oesophageal cancers. It has been demonstrated that high intensity ultrasound (US) can induce rapid, complete and well-defined coagulation necrosis. For the treatment of this cancer, we designed an applicator that uses an intraductal approach. The active part is an air-backed plane transducer. It has an external water-cooling system and operates at 10 MHz. Ex vivo experiments conducted on pig liver demonstrated the ability of this applicator to generate, by rotating the transducer, circular or sector-based coagulation necroses at predetermined depths up to 13 mm, with an excellent angular precision. The treatment of sector-based oesophageal tumours may be critical, where both malignant and healthy tissues are covered by the US beam. Thus, in vivo trials were conducted on five healthy pig oesophaguses to determine the maximal thermal dose that will not induce a perforation of the oesophagus or surrounding tissues. From the results of previous studies, this dose is high enough to treat pathological tissues. These promising results indicate that this US system represents a safe and effective tool for the clinical treatment of oesophageal tumours.
authors.affiliation: INSERM, Lyon, France. melodemia@lyon.inserm.fr
authors.forename: David
authors.initials: D
authors.lastname: Melodelima
authors.forename: Cyril
authors.initials: C
authors.lastname: Lafon
authors.forename: Frederic
authors.initials: F
authors.lastname: Prat
authors.forename: Yves
authors.initials: Y
authors.lastname: Theillère
authors.forename: Alexei
authors.initials: A
authors.lastname: Arefiev
authors.forename: Dominique
authors.initials: D
authors.lastname: Cathignol
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000295:instrumentation*; D004867:Equipment Design; D004938:Esophageal Neoplasms / Q000628:therapy*; D008297:Male; D010166:Palliative Care / Q000379:methods*; D013552:Swine; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods