Effects of the beta1-selective adrenergic antagonist betaxolol on electroretinography in the perfused cat eye.
The effects of the beta1-selective adrenergic antagonist betaxolol on electroretinography (ERG) were studied in the isolated and arterially perfused cat eye. Betaxolol increased the perfusion flow rate, significantly at the administrations of more than 50 microM concentrations and induced a dose-related, reversible increase in the amplitudes of both the a-wave and b-wave of ERG. These results suggest that the calcium-channel blocking mechanism of betaxolol has a beneficial influence on ocular blood flow and retinal electrical activity in response to light. As it is known that ERG is a good indicator of the functional integrity of the retina, this indicates that betaxolol could be an ideal drug for treating glaucoma in which ischemia is involved to some extent.
Uji
Yukitaka
Y
Department of Ophthalmology, Mie University School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan.
Kuze
Manami
M
Matubara
Hisashi
H
Doi
Motoaki
M
Sasoh
Mikio
M
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D015784:Betaxolol / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000187:drug effects*; D010477:Perfusion; D012039:Regional Blood Flow; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D012171:Retinal Vessels / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D015784:Betaxolol