TMC-264, a novel antiallergic heptaketide produced by the fungus Phoma sp. TC 1674.
[structure: see text] TMC-264 (1), a novel tricyclic heptaketide with a unique chloro-1H-dibenzo[b,d]pyran-4,6-dione skeleton, was discovered from the fungus Phoma sp. TC 1674. The structure was elucidated on the basis of NMR analyses of normal abundance and biosynthetically (13)C-enriched TMC-264. TMC-264 showed potent inhibitory activity against tyrosine phosphorylation of STAT6.
Sakurai
Masaaki
M
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-50 Kawagishi-2-chome, Toda-shi, Saitama 335-8505, Japan.
Nishio
Maki
M
Yamamoto
Kouzou
K
Okuda
Toru
T
Kawano
Kimio
K
Ohnuki
Tetsuo
T
D005658:Fungi / Q000737:chemistry* / Q000145:classification; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010766:Phosphorylation / Q000187:drug effects; D019000:Phosphotyrosine / Q000378:metabolism; D050800:STAT6 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism
D006575:Heterocyclic Compounds, 3-Ring; D050800:STAT6 Transcription Factor; C476504:TMC-264; D015534:Trans-Activators; D019000:Phosphotyrosine