Autoimmunity to glutamate receptors in the central nervous system.
Autoimmunity to glutamate receptors (GluR) of the central nervous system offers an attractive model to begin the experimental dissection of the etiology of immune-related neurodegenerative diseases. Here we discuss the known mechanisms of generating autoimmunity to different members of the GluR neurotransmitter receptor family within the unique environment of the brain and how autoantibody-receptor interactions contribute to abnormal neurotransmission and eventually pathology.
Gahring
Lorise C
LC
Salt Lake City VA-GRECC, University of Utah School of Medicine, Department of Internal Medicine, 84132, USA. Lorise.Gahring@HSC.Utah.edu
Rogers
Scott W
SW
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000276:immunology / Q000473:pathology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D017470:Receptors, Glutamate / Q000235:genetics / Q000276:immunology*; D017386:Sequence Homology, Amino Acid
D017470:Receptors, Glutamate