title: Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects.
abstract: We examined fasting plasma insulin, acylation-stimulating protein (ASP), leptin, adiponectin, ghrelin, and metabolic/cardiovascular risk profile before and 15 +/- 6 months after isolated Roux-en-Y gastric bypass surgery in 50 morbidly obese subjects. Average preoperative plasma lipids were mostly normal, whereas ASP, insulin, and leptin were elevated, and adiponectin and ghrelin were decreased. Postoperatively, body weight decreased significantly (-36.4 +/- 9.6%) and was best predicted by preoperative adiponectin concentration in weight-stable subjects (r = -0.59; P = 0.02). Plasma lipids and insulin resistance improved, leptin and ASP decreased (-76.3 +/- 14.6% and -35.9 +/- 52.2%; P < 0.001), and adiponectin increased (50.1 +/- 47.0%; P < 0.001). The decrease in apolipoprotein B was best predicted by the decrease in ASP (r = 0.55; P = 0.009), whereas the improved postoperative insulin sensitivity was best predicted by the increase in adiponectin (r = 0.70; P = 0.01). Despite bypassing 95% of the stomach and isolating the fundus from contact with ingested nutrients, circulating ghrelin did not decrease after surgery. In fact, plasma ghrelin increased postoperatively in the subset of subjects undergoing active weight loss (+60.5 +/- 23.2%; P < 0.001); ghrelin, however, remained unchanged in weight-stable subjects. In summary, 1) preoperative adiponectin concentrations may be predictive of the extent of weight loss; 2) changes in ASP and adiponectin are predictive of decreased apolipoprotein B and improved insulin action, respectively; and 3) plasma ghrelin increases after gastric bypass surgery in patients experiencing active weight loss.
authors.affiliation: Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montréal, Québec, Canada.
authors.forename: May
authors.initials: M
authors.lastname: Faraj
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.forename: Steve
authors.initials: S
authors.lastname: Phélis
authors.forename: David
authors.initials: D
authors.lastname: Blank
authors.forename: Allan D
authors.initials: AD
authors.lastname: Sniderman
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
mesh_terms: D052242:Adiponectin; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis*; D015926:Complement C3a / Q000031:analogs & derivatives*; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D036361:Peptide Hormones / Q000097:blood*; D011506:Proteins / Q000032:analysis*; D012727:Sex Characteristics
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D001798:Blood Proteins; D054439:Ghrelin; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D036361:Peptide Hormones; D011506:Proteins; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a