Preparation and cancer cell invasion inhibitory effects of C16-alkynic fatty acids.
Five C(16)-alkynic fatty acids (2-6) were prepared and examined their inhibitory effects on cancer cell invasion. It has been found that hexadeca-6,8,10-triynoic acid (5) and hexadeca-8,10,12-triynoic acid (6) exhibit similar potent inhibitory activities with that of octadeca-8,10,12-triynoic acid (1) which was isolated from Scurrula atropurpurea (Loranthaceae).
Ohashi
Kazuyoshi
K
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzo, 1 Gakuen-cho, Hiroshima, Japan.
Winarno
Hendig
H
Mukai
Mutsuko
M
Shibuya
Hirotaka
H
D000480:Alkynes / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D028183:Loranthaceae; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D000480:Alkynes; D000970:Antineoplastic Agents; D005227:Fatty Acids; D006131:Growth Inhibitors; D010936:Plant Extracts