Brief report: carotid intima-media thickness in heavily pretreated HIV-infected patients.
The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p <.05) but not different from control group 2 IMT values. Positive independent associations of IMT with the total-to-HDL cholesterol ratio and waist circumference existed for cases (p <.05) but not for controls. Case IMT did not correlate with parameters of HIV infection and antiretroviral treatment. This case-control study suggests that lipid disturbances, mainly hypoHDLemia, may be involved in the early atherosclerotic process in HIV-infected patients.
Chironi
Gilles
G
Centre de Médecine Préventive Cardiovasculaire and Unité CNRS UMR7131, Hôpital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France.
Escaut
Lelia
L
Gariepy
Jerome
J
Cogny
Anne
A
Teicher
Elina
E
Monsuez
Jean-Jacques
JJ
Levenson
Jaime
J
Simon
Alain
A
Vittecoq
Daniel
D
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001786:Blood Glucose; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography
D001786:Blood Glucose; D008055:Lipids