[Effects of resveratrol on Ca2+, Mg(2+)-ATPase activities after spinal cord trauma in rats].
OBJECTIVE
To study the effects of resveratrol on Ca2+, Mg(2+)-ATPase activities after spinal cord trauma in rats.


METHODS
The weight-dropping method was used to produce the experimental spinal cord injury(SCI) in adult rats. 500 mg/kg, 100 mg/kg resveratrol (Res) and 100 mg/kg methylprednisolone (MPSS) were given intraperitoneally respectively, immediately after SCI. And then the effects of Res on Ca2+, Mg(2+)-ATPase activities were observed at 1 h, 24 h, 48 h after SCI and compared with MPSS.


RESULTS
Res could obviously augment Ca(2+)-ATPase, Mg(2+)-ATPase and Ca2+, Mg(2+)-ATPase activities almost all at 1 h after SCI in rats(P < 0.05 [symbol: see text] 0.003) with the greatest improving rates over 71%, 180%, 120%, but at 48 h for Mg(2+)-ATPase. The effects of Res were the same as or greater than those of MPSS.


CONCLUSIONS
Res may effectively protect the spinal cord through improving Ca2+, Mg(2+)-ATPase system in SCI so as to inhibit the Ca2+, Mg2+ ionic micro-environment change in the injured spinal cord. It suggested that Res may be having potent therapeutic effect on SCI.
Yang
Yingbao
Y
First Military Medical University, Guangzhou 510515.
Piao
Yingjie
Y
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000187:drug effects / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013119:Spinal Cord Injuries / Q000201:enzymology*; D013267:Stilbenes / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D013267:Stilbenes; D017301:Ca(2+) Mg(2+)-ATPase; D000077185:Resveratrol; D008775:Methylprednisolone