The prevention of preterm labour -- corticotropin releasing hormone type 1 receptors as a target for drug design and development.
The role of the corticotropin releasing hormone in the onset of labour and the subsequent medicinal chemistry implications of CRH antagonists for the prevention of premature birth, and identification of the CRH type 1 receptor as the target for this drug design, are reviewed here.
Keller
P A
PA
Department of Chemistry, The University of Wollongong, Wollongong, NSW, Australia 2522. paul_keller@uow.edu.au
Kirkwood
K
K
Morgan
J
J
Westcott
S
S
McCluskey
A
A
D000328:Adult; D000595:Amino Acid Sequence; D003346:Corticotropin-Releasing Hormone / Q000502:physiology / Q000627:therapeutic use*; D015195:Drug Design; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D000099052:CRF Receptor, Type 1
D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1; D003346:Corticotropin-Releasing Hormone