Endobronchial post-transplant lymphoproliferative disorder and its management with photodynamic therapy: a case report.
Post-transplant lymphoproliferative disorder (PTLD) is a recognized complication of solid-organ transplantation. We describe a 56-year-old man with end-stage idiopathic pulmonary fibrosis who underwent right-sided single-lung transplantation and who had biopsy-proven PTLD involving the main bronchi 3 months later. The lesions recurred despite endobronchial electrosurgery and systemic therapy with interferon for 3 months. Interferon was deceased and anti-CD20 therapy and photodynamic therapy were performed concurrently using flexible bronchoscopy. The subsequent follow-up endobronchial biopsy specimen results were negative for PTLD. This case is the first reported use of photodynamic therapy combined with anti-CD20 for treating PTLD. Endobronchial PTLD is a rare complication of lung transplantation and can be managed successfully with photodynamic therapy.
Legere
Brian M
BM
Coastal Pulmonary Medicine, Wilmington, North Carolina, USA.
Saad
Cynthia P
CP
Mehta
Atul C
AC
D001982:Bronchial Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D001999:Bronchoscopy; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011658:Pulmonary Fibrosis / Q000473:pathology / Q000601:surgery*