[ICE expression in laryngeal carcinoma and it's clinical relationship].
OBJECTIVE
To study the role of ICE in Laryngeal Carcinoma.


METHODS
Using polyclonal antibody for ICE gene protein, 73 cases of laryngeal carcinoma, 30 cases dysplasia and 5 cases normal were stained by SP immunohistochemistry.


RESULTS
ICE protein is situated mainly in the upper of epithelium and a little in the basal layer. Compared with the normal epithelium, the expression of ICE in the dysplasia is decreased significantly (P < 0.01). There is a relationship between expression of ICE in laryngeal carcinoma and the degree of differentiation. The better differentiation, the much expression of ICE (P < 0.05).


CONCLUSIONS
There is an intimate relationship between innormal expression protein of ICE and dysplasia, and that of between laryngeal carcinoma and prognosis. The expression of ICE may be a monitoring marker for prognosis of laryngeal carcinoma.
Wang
Mingfang
M
Department of Otorhinolaryngology, the First Affiliated Hospital, Henan.
Xing
Luqi
L
Lei
Wanjun
W
D000328:Adult; D000368:Aged; D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D020170:Caspase 1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D020170:Caspase 1