Anterior cingulotomy for refractory obsessive-compulsive disorder.
OBJECTIVE
This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months.


METHODS
Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation.


RESULTS
The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy.


CONCLUSIONS
Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.
Kim
C-H
CH
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
Chang
J W
JW
Koo
M-S
MS
Kim
J W
JW
Suh
H S
HS
Park
I H
IH
Lee
H S
HS
D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006179:Gyrus Cinguli / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000523:psychology* / Q000601:surgery*; D011612:Psychosurgery / Q000009:adverse effects / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome