title: Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: cross-sectional results from the Canadian Multicentre Osteoporosis Study.
abstract: This cross-sectional cohort study of 5566 women and 2187 men 50 years of age and older in the population-based Canadian Multicentre Osteoporosis Study was conducted to determine whether reported past diseases are associated with bone mineral density or prevalent vertebral deformities. We examined 12 self-reported disease conditions including diabetes mellitus (types 1 or 2), nephrolithiasis, hypertension, heart attack, rheumatoid arthritis, thyroid disease, breast cancer, inflammatory bowel disease, neuromuscular disease, Paget's disease, and chronic obstructive pulmonary disease. Multivariate linear and logistic regression analyses were performed to determine whether there were associations among these disease conditions and bone mineral density of the lumbar spine, femoral neck, and trochanter, as well as prevalent vertebral deformities. Bone mineral density measurements were higher in women and men with type 2 diabetes compared with those without after appropriate adjustments. The differences were most notable at the lumbar spine (+0.053 g/cm2), femoral neck (+0.028 g/cm2), and trochanter (+0.025 g/cm2) in women, and at the femoral neck (+0.025 g/cm2) in men. Hypertension was also associated with higher bone mineral density measurements for both women and men. The differences were most pronounced at the lumbar spine (+0.022 g/cm2) and femoral neck (+0.007 g/cm2) in women and at the lumbar spine (+0.028 g/cm2) in men. Although results were statistically inconclusive, men reporting versus not reporting past nephrolithiasis appeared to have clinically relevant lower bone mineral density values. Bone mineral density differences were -0.022, -0.015, and -0.016 g/cm2 at the lumbar spine, femoral neck, and trochanter, respectively. Disease conditions were not strongly associated with vertebral deformities. In summary, these cross-sectional population-based data show that type 2 diabetes and hypertension are associated with higher bone mineral density in women and men, and nephrolithiasis may be associated with lower bone mineral density in men. The importance of these associations for osteoporosis case finding and management require further and prospective studies.
authors.affiliation: Department of Medicine, University of Calgary. Calgary, Alberta, Canada. dahanley@ucalgary.ca
authors.forename: D A
authors.initials: DA
authors.lastname: Hanley
authors.forename: J P
authors.initials: JP
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Tenenhouse
authors.forename: W P
authors.initials: WP
authors.lastname: Olszynski
authors.forename: G
authors.initials: G
authors.lastname: Ioannidis
authors.forename: C
authors.initials: C
authors.lastname: Berger
authors.forename: J C
authors.initials: JC
authors.lastname: Prior
authors.forename: L
authors.initials: L
authors.lastname: Pickard
authors.forename: T M
authors.initials: TM
authors.lastname: Murray
authors.forename: T
authors.initials: T
authors.lastname: Anastassiades
authors.forename: S
authors.initials: S
authors.lastname: Kirkland
authors.forename: C
authors.initials: C
authors.lastname: Joyce
authors.forename: L
authors.initials: L
authors.lastname: Joseph
authors.forename: A
authors.initials: A
authors.lastname: Papaioannou
authors.forename: S A
authors.initials: SA
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Poliquin
authors.forename: J D
authors.initials: JD
authors.lastname: Adachi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007669:Kidney Calculi / Q000150:complications; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology*; D013131:Spine / Q000002:abnormalities*