title: The case for early detection.
abstract: Early detection represents one of the most promising approaches to reducing the growing cancer burden. It already has a key role in the management of cervical and breast cancer, and is likely to become more important in the control of colorectal, prostate and lung cancer. Early-detection research has recently been revitalized by the advent of novel molecular technologies that can identify cellular changes at the level of the genome or proteome, but how can we harness these new technologies to develop effective and practical screening tests?
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. retzioni@fhcrc.org
authors.forename: Ruth
authors.initials: R
authors.lastname: Etzioni
authors.forename: Nicole
authors.initials: N
authors.lastname: Urban
authors.forename: Scott
authors.initials: S
authors.lastname: Ramsey
authors.forename: Martin
authors.initials: M
authors.lastname: McIntosh
authors.forename: Stephen
authors.initials: S
authors.lastname: Schwartz
authors.forename: Brian
authors.initials: B
authors.lastname: Reid
authors.forename: Jerald
authors.initials: J
authors.lastname: Radich
authors.forename: Garnet
authors.initials: G
authors.lastname: Anderson
authors.forename: Leland
authors.initials: L
authors.lastname: Hartwell
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002986:Clinical Trials as Topic; D005819:Genetic Markers; D006801:Humans; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000517:prevention & control*; D012107:Research Design; D016019:Survival Analysis; D014481:United States
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers