title: Sphingolipids and the immune system.
abstract: The importance of sphingolipids, not only as components of plasma membranes but also as key players in different physiological and pathophysiological cellular events, is now emerging. This review gathers together what the authors feel are the most relevant data, present in the literature, regarding the roles and the effects of sphingolipids, such as ceramide, ceramide-1-phosphate (C1P), sphingosine (SP) and sphingosine-1-phosphate (S1P), on the development, activation and regulation of the immune system.
authors.affiliation: Department of Experimental Medicine, University of L'Aquila, Via Vetoio 10, Coppito 2, 67100 L'Aquila, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Cinque
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Marzio
authors.forename: Carla
authors.initials: C
authors.lastname: Centi
authors.forename: Cristiana
authors.initials: C
authors.lastname: Di Rocco
authors.forename: Carlo
authors.initials: C
authors.lastname: Riccardi
authors.forename: M
authors.initials: M
authors.lastname: Grazia Cifone
mesh_terms: D000818:Animals; D002518:Ceramides / Q000276:immunology; D007107:Immune System / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D013107:Sphingolipids / Q000276:immunology* / Q000378:metabolism
chemical_list: D002518:Ceramides; D013107:Sphingolipids