title: Helper T-cell-regulated B-cell immunity.
abstract: Helper T-cell-regulated B-cell responses constitute a major component of the immune response to many pathogens. Spatially and temporally organized cognate intercellular communication within secondary lymphoid organs is the critical regulating event in this complex adaptive response to antigen. Here, we discuss what is known of these molecular exchanges and their cellular consequences in a serial synapsis model of adaptive immunity.
authors.affiliation: Department of Immunology, Duke University Medical Center, Box 3010, Durham, NC 27705, USA. mcheyzer@scripps.edu
authors.forename: Michael
authors.initials: M
authors.lastname: McHeyzer-Williams
authors.forename: Louise
authors.initials: L
authors.lastname: McHeyzer-Williams
authors.forename: Joanne
authors.initials: J
authors.lastname: Panus
authors.forename: Rebecca
authors.initials: R
authors.lastname: Pogue-Caley
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bikah
authors.forename: David
authors.initials: D
authors.lastname: Driver
authors.forename: Michael
authors.initials: M
authors.lastname: Eisenbraun
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007110:Immunity, Active; D007156:Immunologic Memory; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte