Preventing microvascular diabetic complications in children and adolescents: looking beyond glycaemic control.
Type 1 diabetes mellitus is associated with the development of micro- and macrovascular disease, and diabetic angiopathy in children and adolescents. It is represented mainly by microangiopathy, characterised by structural changes in the eye, renal glomeruli and peripheral nerves. The pathogenesis of the vascular complications of diabetes is controversial, but without any doubt, endothelial dysfunction play an important role in the pathogenesis of glomerulosclerosis and atherosclerosis. Preventive strategies for these three major complications are discussed in this review. Appropriate surveillance for the earliest evidence of microvascular disease should begin at the onset of puberty, and after 3 - 5 years of diabetes. Therapeutic interventions, particularly excellent metabolic control, may be almost effective in preventing complication onset, or significantly retarding the rate of progression.
Verrotti
Alberto
A
Department of Pediatrics-Policlinico Colle Dell'Ara, University G. D'Annunzio, Via dei Vestini 5, I-66013 Chieti, Italy.
Trotta
Daniela
D
Salladini
Carmela
C
Laura
Madonna
M
Chiarelli
Francesco
F
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D003928:Diabetic Nephropathies / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans