Regulation of Expression of Lymphocyte Activation Markers by Neutrophil Factors Secreted during Pregnancy.
The work was outlined to elucidate contribution of soluble factors produced by peripheral neutrophils from healthy pregnant women and those with EPH-gestosis to regulation of expression of surface activation markers by donor lymphocytes. It was found out that in healthy pregnant women neutrophil factors stimulated expression of HLA-DR and CD25 antigens by T lymphocytes. In women with EPH-gestosis neutrophil factors, which comprised soluble antigen of leukocytes 2 (SAL-2), enhanced expression of CD25 antigen in B subset. Presumably, the effects were caused by activation of SAL-2 neutrophil secretion during EPH-gestosis. Impaired neutrophil secretion in women with EPH-gestosis may lead to activation of B lymphocytes through Th2 recruitment and triggering of the autoimmune reactions.
Sotnikova
Nataliya Yu.
NY
V.N. Gorodkov Research Institute for Maternity and Childhood, Ivanovo, Russia.
Antsiferova
Yulia S.
YS
Petrunin
Dmitry D.
DD
Kudryashova
Anna V.
AV
Kroshkina
Nataliya V.
NV
Pavluk
Alexander S.
AS