Evaluation of wound healing activity of some herbal formulations.
The wound healing activity of two herbal formulations (Himax ointment and lotion) containing Indradaru extract, i.e. Arjuna bark (Terminalia arjuna, Family-Combretaceae), extract was evaluated for its wound healing potential in two types of wound models in rats (i) excision wound model and (ii) incision wound model. Both the formulations responded significantly in both the wound models tested. The results were also comparable to that of the standard drug nitrofurazone used as a standard drug for comparison in this present investigation. The results were also comparable in terms of wound contracting ability, epithelization period, tensile strength and regeneration of tissues at the wound area. Thus, this investigation con fi rms the use of the Himax ointment and lotion containing Terminalia arjuna extract as a wound-healing agent as known from folklore medicine.
Mukherjee
Pulok K
PK
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700032, India.
Mukherjee
Kakali
K
Rajesh Kumar
M
M
Pal
M
M
Saha
B P
BP
D000279:Administration, Cutaneous; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009583:Nitrofurazone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009824:Ointments; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000293:injuries*; D013718:Tensile Strength; D029766:Terminalia; D014945:Wound Healing / Q000187:drug effects; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology
D000891:Anti-Infective Agents, Local; D009824:Ointments; D010936:Plant Extracts; D009583:Nitrofurazone