Induction of kf-1 after repeated electroconvulsive treatment and chronic antidepressant treatment in rat frontal cortex and hippocampus.
It has been proposed that signaling pathways involved in adaptive neural plasticity are long-term targets for the action of electroconvulsive treatment (ECT), which is widely used in the treatment of drug-resistant depression. We have previously performed EST analysis to identify some molecular machinery responsible for antidepressant effect. One of the cDNA fragments identified as antidepressant related genes/ESTs was identified as kf-1 which has a RING-H2 finger motif at the carboxy-terminus. In the present study, we have demonstrated the induction of kf-1 in rat frontal cortex and hippocampus not only after chronic antidepressant treatment, but also after a single and repeated ECT. RING finger proteins are proposed to play some important roles in the ubiquitin-proteasome system. In conclusion, the current investigation has identified kf-1 as a novel molecular target for antidepressants and ECT.
Nishioka
G
G
Department of Psychiatry, School of Medicine, Showa University, Tokyo, Japan.
Yamada
M
M
Kudo
K
K
Takahashi
K
K
Kiuchi
Y
Y
Higuchi
T
T
Momose
K
K
Kamijima
K
K
Yamada
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004597:Electroshock / Q000379:methods*; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D000928:Antidepressive Agents; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C484500:Rnf103 protein, rat