title: Medical management of pituitary adenomas: structural and ultrastructural changes.
abstract: The morphology of the various pituitary cell types is highly dynamic and allows recognition of many cellular functions. Most pituitary cells show morphologic changes that reflect stimulation or inhibition by hormones. Drugs have also been shown to alter the morphology of several pituitary tumor types, allowing a measure of therapeutic efficiency and a careful dissection of the mechanisms of action of various medical therapies. In some cases, these morphologic alterations can evoke diagnostic problems.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Ontario, Canada. sylvia.asa@uhn.on.ca
authors.forename: Sylvia L
authors.initials: SL
authors.lastname: Asa
authors.forename: Shereen
authors.initials: S
authors.lastname: Ezzat
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D015175:Prolactinoma / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D006062:Gonadotropins; D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin