Developing experimental models to address traumatic brain injury in children.
Traumatic brain injury (TBI) is the leading cause of injury-related death and disability among children under the age of 15 years in the United States. Epidemiological studies have revealed that even within the pediatric population there are differences in incidence, gender differences, causes, types of injuries sustained, and mortality within age subdivisions. This heterogeneity must be taken into account when developing appropriate models to address TBI in children. This review explores the current developmental TBI models, including fluid percussion, weight drop, and controlled cortical impact. It also addresses unique considerations to modeling pediatric brain injury that require special attention when modeling and designing studies: age appropriateness, injury severity, evaluation of recovery, plasticity, and anesthesia.
Prins
Mayumi L
ML
Division of Neurosurgery, UCLA School of Medicine, Los Angeles, California 90095-7039, USA. mprins@mednet.ucla.edu
Hovda
David A
DA
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D002675:Child, Preschool; D004195:Disease Models, Animal; D006801:Humans; D009473:Neuronal Plasticity; D020127:Recovery of Function; D014949:Wounds, Nonpenetrating / Q000503:physiopathology*