title: Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-kappa paraprotein.
abstract: A case is described of B-cell lymphoma/chronic lymphocytic leukaemia associated with membranous glomerulonephritis in which the subepithelial deposits of immunoglobulin showed kappa light chain restriction by immunofluorescence. Surface IgG-kappa immunoglobulin was demonstrated on the malignant B cells, and a monoclonal protein of the same type was eluted from kidney. The mechanism of membranous glomerulonephritis in this type of lymphoid malignancy is clearly different from that in epithelial malignancies.
authors.affiliation: Renal Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. d.j.evans@ic.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Evans
authors.forename: Momir
authors.initials: M
authors.lastname: Macanovic
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Dunn
authors.forename: Charles D
authors.initials: CD
authors.lastname: Pusey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007145:Immunoglobulin kappa-Chains / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000473:pathology*; D010266:Paraproteins / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D011655:Pulmonary Embolism / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D010266:Paraproteins