Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient.
We describe a patient who developed multi-organ failure with reactive hemophagocytic syndrome secondary to disseminated histoplasmosis 8 months after orthotopic heart transplantation. The patient responded fully to a prolonged course of therapy with amphotericin B and remains free of recurrence. Disseminated histoplasmosis and reactive hemophagocytic syndrome have rarely been described in the setting of cardiac transplantation and never before in combination.
Masri
Kalil
K
Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA.
Mahon
Niall
N
Rosario
Adriana
A
Mirza
Imran
I
Keys
Thomas F
TF
Ratliff
Norman B
NB
Starling
Randall C
RC
D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000601:surgery*; D016027:Heart Transplantation / Q000009:adverse effects*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006660:Histoplasmosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications