title: Thiolate-bridged nickel-copper complexes: a binuclear model for the catalytic site of acetyl coenzyme a synthase?
abstract: Reaction of the nickel metalloligands [EtN2S2]Ni (EtN2S2, N,N'-diethyl-3,7-diazanonane-1,9-dithiolate) or K2[Ni(phmi)] (phmi, N,N'-1,2-phenylenebis(2-sulfanyl-2-methylpropionamide)) with [Cu(CH3CN)4]BF4 yields polynuclear complexes in which two copper(I) ions are bridged by the nickel metalloligands. Alternatively, reaction with the Cu(I) source, [(PhTttBu)Cu] (PhTttBu, phenyltris((tert-butylthio)methyl)borate), generates discrete binuclear NiCu complexes that may serve as models of the acetyl coenzyme A synthase active site. The binuclear species react reversibly with CO via rupture of the thiolate bridges.
authors.affiliation: Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
authors.forename: Rangan
authors.initials: R
authors.lastname: Krishnan
authors.forename: Janis K
authors.initials: JK
authors.lastname: Voo
authors.forename: Charles G
authors.initials: CG
authors.lastname: Riordan
authors.forename: Lev
authors.initials: L
authors.lastname: Zahkarov
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
mesh_terms: D000106:Acetate-CoA Ligase / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D003300:Copper; D009532:Nickel; D000106:Acetate-CoA Ligase