Perineural capsaicin treatment attenuates reactive hyperaemia in the rat skin.
The neural mechanisms of reactive cutaneous hyperaemia were studied by using a novel experimental approach: the simultaneous measurement of cutaneous blood flow by laser-Doppler flowmetry in adjacent innervated and chemodenervated skin regions of the rat hindpaw served by the same artery. Transient occlusion of the femoral artery (0.5-6 min) resulted in reactive hyperaemia that was greatly reduced in the chemodenervated region. After 3 min arterial occlusion, peak cutaneous blood flow was 109+/-13% vs. 53+/-7%* (% change from baseline, n=11, *P<0.05), and the total hyperaemic response was 110+/-21 vs. 52+/-12* (arbitrary perfusion units) in intact vs. chemodenervated skin regions, respectively. The findings provide clear evidence for the involvement of peptidergic capsaicin-sensitive afferent nerves in the mechanism of reactive cutaneous hyperaemia.
Domoki
Ferenc
F
Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720, Szeged, Hungary.
Sántha
Péter
P
Bari
Ferenc
F
Jancsó
Gábor
G
D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000187:drug effects*; D005263:Femoral Artery / Q000502:physiology; D006940:Hyperemia / Q000188:drug therapy* / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D002211:Capsaicin