Nucleocytoplasmic transport: navigating the channel.
Nucleocytoplasmic transport is mediated by shuttling receptors that recognize specific signals on protein or RNA cargoes and translocate the cargoes through the nuclear pore complex. Transport receptors appear to move through the nuclear pore complex by facilitated diffusion, involving repeated cycles of binding to and dissociation from nucleoporins with phenylalanine-glycine motifs. We discuss recent experimental approaches and results that have begun to provide molecular insight into the mechanisms by which transport complexes traverse the nuclear pore complex, and point out the significant gaps in understanding that remain.
Bednenko
Janna
J
Department of Cell, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Cingolani
Gino
G
Gerace
Larry
L
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D001693:Biological Transport, Active; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000201:enzymology; D007473:Ion Channels / Q000502:physiology*; D008958:Models, Molecular; D011487:Protein Conformation; D028961:beta Karyopherins / Q000737:chemistry / Q000378:metabolism*
D007473:Ion Channels; D028961:beta Karyopherins