Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain.
OBJECTIVE
Weight gain, leading to further morbidity and poor treatment adherence, is a common consequence of treatment with antipsychotic drugs. A recent study showed that a polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene is associated with antipsychotic-induced weight gain. The authors determined whether this association held true for weight gain after clozapine treatment.


METHODS
Thirty-two Chinese Han patients with first-episode schizophrenia were genotyped for the -759C/T polymorphism and had weight changes monitored after 6 weeks of clozapine treatment.


RESULTS
The authors found that the 10 patients with the -759T variant allele showed significantly less weight gain than those without this allele. The effect was strongest in the male patients and not apparent in the female patients.


CONCLUSIONS
These findings identify an important genetic factor associated with clozapine-induced weight increases in schizophrenia.
Reynolds
Gavin P
GP
Department of Biomedical Science, University of Sheffield, UK. g.p.reynolds@sheffield.ac.uk
Zhang
ZhiJun
Z
Zhang
XiaoBin
X
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D015992:Body Mass Index; D002681:China / Q000208:ethnology; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D012737:Sex Factors; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*
D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D003024:Clozapine