title: [Mapping studies of type 2 diabetes mellitus gene in one family].
abstract: OBJECTIVE
  To disclose the molecular genetic mechanism of type 2 diabetes mellitus and to determine chromosomal location of type 2 diabetes mellitus gene.
  
  
  METHODS
  Genome-wide screening and genotyping were conducted in a family of type 2 diabetes mellitus, and linkage analysis by LINKAGE and GENEHUNTER package was used to determine the potential chromosomal location of the family of type 2 diabetes mellitus gene.
  
  
  RESULTS
  Evidence of linkage was found at the long arm of chromosome 2. The maximum Lod score is 1.80 and non-parameter Lod score is 5.06.
  
  
  CONCLUSIONS
  The type 2 diabetes mellitus gene of the family is located at 2q.
authors.affiliation: Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200032 P. R. China. liybman@hotmail.com
authors.forename: Yuebin
authors.initials: Y
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chenhui
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xiong
authors.forename: Shijie
authors.initials: S
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree