title: Immunogenicity and immunological priming of the serogroup a portion of a bivalent meningococcal A/C conjugate vaccine in 2-year-old children.
abstract: Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels.
authors.affiliation: Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, U.K. hjoseph@nw.phls.org.uk
authors.forename: Helen
authors.initials: H
authors.lastname: Joseph
authors.forename: Robert
authors.initials: R
authors.lastname: Ryall
authors.forename: Mike
authors.initials: M
authors.lastname: Bybel
authors.forename: Thomas
authors.initials: T
authors.lastname: Papa
authors.forename: Jenny
authors.initials: J
authors.lastname: MacLennan
authors.forename: Jim
authors.initials: J
authors.lastname: Buttery
authors.forename: Raymond
authors.initials: R
authors.lastname: Borrow
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology* / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000276:immunology*; D009345:Neisseria meningitidis; D013997:Time Factors; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate