Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea.
Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED(50)=0.02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively).
Kuo
Yao-Haur
YH
National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C. kuoyh@cma23.nricm.edu.tw
Kuo
Yu-Jen
YJ
Yu
Ang-Su
AS
Wu
Ming-Der
MD
Ong
Chi-Wi
CW
Yang Kuo
Li-Ming
LM
Huang
Jo-Ti
JT
Chen
Chieh-Fu
CF
Li
Shyh-Yuan
SY
D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D035741:Vernonia
D003603:Cytotoxins; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes