[Expression of extracellular matrix glycoprotein tenascin in the laryngeal cancer].
OBJECTIVE
Tenascin (TN) is an extracellular matrix glycoprotein upregulated in some pathological processes. In the study, we investigated its expression in the laryngeal epithelial lesions and explored the relation of TN with the laryngeal tumor.


METHODS
Expression of TN were examined by immunohistochemistry SP method in sections of laryngeal lesions from 4 leukoplakia, 8 papilloma, 7 in situ carcinoma and 39 invasive squamous cell cancer patients. An automatic image analyzer was used to analyze the staining results.


RESULTS
No expression, of TN was found in the extracellular matrix of papilloma or leukoplakia. Only a weak stain was found at their epithelialstromal interface in seldom sections. There was a weak extracellular matrix stain of TN in all situ carcinoma and the stain difference between in situ cancer and papilloma or leukoplakia was significant (P < 0.001). There was a much stronger extracellular matrix stain in invasive cancer than that in situ cancer (P < 0.01). The differences of TN expression among different T stage and histological grade of invasive cancer were insignificant (P > 0.05). But there was a significantly stronger TN stain in the cases with lymph node metastasis than those without lymph node metastasis (P < 0.01).


CONCLUSIONS
TN expression may be involved in the oncogenesis and metastasis of laryngeal squamous cell cancer. It was implicated that the risk of pre cancerous lesions progress to cancer.
Zhang
Song
S
Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Liu
Qiurun
Q
Liu
Zheng
Z
Hua
Xiaoyang
X
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D019063:Tenascin / Q000096:biosynthesis*
D019063:Tenascin