Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins.
Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these coumarins on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.
Ito
Chihiro
C
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
Itoigawa
Masataka
M
Mishina
Yoshitaka
Y
Filho
Valdir Cechinel
VC
Enjo
Fumio
F
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Furukawa
Hiroshi
H
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000956:Antigens, Viral / Q000187:drug effects; D001938:Brazil; D029759:Calophyllum / Q000737:chemistry*; D002478:Cells, Cultured / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D016393:Lymphoma, B-Cell; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D003374:Coumarins; C033305:Epstein-Barr virus early antigen; C476664:brasimarin A; C476663:brasimarin B; C476665:brasimarin C; D013755:Tetradecanoylphorbol Acetate