Metachronous Wilms tumor associated with pulmonary embolism: how can we detect these cases early? A case report and literature review.
A 4-year-old girl developed right metachronous Wilms tumor 2 years after completing treatment for a left-sided stage I Wilms tumor. The original treatment included 7 weeks of chemotherapy, delayed nephrectomy, and another 3 weeks of chemotherapy. The metachronous tumor on the right side extended into the inferior vena cava and right atrium. She developed pulmonary embolism as a result. She received chemotherapy and developed liquifaction of the tumor and toxic shock. She also had surgery. The patient is alive 3 years after the original diagnosis and 10 months after the relapse. The authors report this unusual case and discuss whether these cases can be identified early.
Ahmed
R
R
Department of Paediatric Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom. ahmedri@aol.com
al-Salti
W
W
Raafat
F
F
Morland
B
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D009392:Nephrectomy; D011655:Pulmonary Embolism / Q000209:etiology*; D009396:Wilms Tumor / Q000150:complications* / Q000175:diagnosis / Q000628:therapy