A comparative study of electroporation and iontophoresis for percutaneous penetration of naproxen.
Using side-by-side compartment diffusion cell and rat skin, the in vitro percutaneous penetration of naproxen by electroporation and iontophoresis with different energy was investigated and compared. Both electroporation and iontophoresis could obviously increase the penetration of naproxen through rat skin. The enhancing effect of electroporation was not always better than that of iontophoresis. The enhancing effect was dependent on the energy of the electrical field.
Hu
Q H
QH
Department of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China. Hu_qh@mail.hz.zj.cn
Liang
W Q
WQ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004058:Diffusion; D018274:Electroporation; D066298:In Vitro Techniques; D007478:Iontophoresis; D009288:Naproxen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012869:Skin Absorption / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen