Palpebral edema as a cutaneous manifestation of hyperthyroidism.
Three cases of palpebral edema associated with Graves' disease are described. These patients had unilateral edema and minimal erythema of the upper eyelid. Notable was that, histologically, dermal edema and dilation of lymphatic vessels were observed, but deposition of mucopolysaccharides was not. In 2 cases, edema of the eyelid was resistant to treatment with an antithyroid drug. Unilateral edema of the upper eyelid is an important cutaneous manifestation that indicates the presence of hyperthyroidism.
Higuchi
Tetsuya
T
Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Japan. tetsuya.derm@tmd.ac.jp
Satoh
Takahiro
T
Yokozeki
Hiroo
H
Katayama
Ichiro
I
Nishioka
Kiyoshi
K
D004487:Edema / Q000150:complications* / Q000473:pathology; D004890:Erythema / Q000150:complications / Q000473:pathology; D005141:Eyelid Diseases / Q000150:complications* / Q000473:pathology; D005143:Eyelids / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D012867:Skin / Q000473:pathology