Isolation and X-ray study of an anti-inflammatory active androstene steroid from Acacia nilotica.
3beta-Acetoxy-17beta-hydroxy-androst-5-ene was isolated from aerial parts of Acacia nilotica (L.) Willd (Mimosaceae). The structure of this compound was established by spectral analysis and single crystal X-ray diffraction analysis. The steroid showed dose-dependent anti-inflammatory activity against TPA-induced mouse earedema.
Chaubal
Rohini
R
Mujumdar
A M
AM
Puranik
Vedavati G
VG
Deshpande
V H
VH
Deshpande
N R
NR
D000045:Acacia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D013256:Steroids; D013755:Tetradecanoylphorbol Acetate
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013256:Steroids; D013755:Tetradecanoylphorbol Acetate