title: S-cone electroretinograms in multiple evanescent white dot syndrome.
abstract: Cone electroretinograms (ERGs), elicited by different color flashes under Ganzfeld conditions, were recorded from 6 patients with multiple evanescent white dot syndrome (MEWDS). All of the patients had normal color vision as determined by the Farnsworth Panel D-15 except for one who showed non-specific errors. The b-waves elicited from short wavelength sensitive (S-) cones were reduced more than the mixed long (L-) and middle (M-) wavelength sensitive cones in the affected eyes. The ratio of the S-cone b-wave amplitude of the affected eyes to that of the normal fellow eyes was significantly lower than the comparable ratio for the L- and M-cone ERG b-waves (p=0.012). The S-cone ERGs recorded from 2 patients recovered to normal levels after their symptoms abated. These ERG results indicate that the S-cone system is more impaired than the L- and M-cone systems in the acute stage of MEWDS, and the changes in the S-cones may be reversible.
authors.affiliation: Department of Ophthalmology, Toho University Sakura Hospital, Sakura, Japan. shuyama@med.toho-u.ac.jp
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Hayashi
authors.forename: Mieko
authors.initials: M
authors.lastname: Tsuruoka
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Itsuro
authors.initials: I
authors.lastname: Tsukahara
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D003118:Color Perception / Q000502:physiology; D004596:Electroretinography; D005260:Female; D006801:Humans; D010775:Photic Stimulation; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D012164:Retinal Diseases / Q000503:physiopathology*; D013577:Syndrome