Adenovirus dodecahedron allows large multimeric protein transduction in human cells.
Adenovirus dodecahedron is a virus-like particle composed of only two viral proteins of human adenovirus serotype 3 that are responsible for virus attachment and internalization. We show here that this dodecameric particle, devoid of genetic information, efficiently penetrates human cells and can deliver large multimeric proteins such as immunoglobulins.
Fender
P
P
Institut de Biologie Structurale, 38027 Grenoble, France. fender@ibs.fr
Schoehn
G
G
Foucaud-Gamen
J
J
Gout
E
E
Garcel
A
A
Drouet
E
E
Chroboczek
J
J
D000260:Adenoviruses, Human / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002213:Capsid / Q000378:metabolism*; D036022:Capsid Proteins / Q000235:genetics / Q000378:metabolism*; D019281:Dimerization; D005822:Genetic Vectors; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D014161:Transduction, Genetic; D014771:Virion / Q000235:genetics / Q000378:metabolism
D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus; C043322:penton protein, adenovirus