[Expression of VEGF and VEGF-C in laryngeal carcinoma and their clinical significance].
OBJECTIVE
To study the gene expression of Vascular Endothelial Growth Factor (VEGF) and Vascular Endothelial Growth Factor C (VEGF-C) in laryngeal carcinoma and their relation with clinic pathologic features.


METHODS
VEGF and VEGF C gene expression in 20 cases of fresh laryngeal carcinoma, cutting edge and normal tissue were examined by reverse transcription polymerase chain reaction (RT-PCR).


RESULTS
The gene expression of VEGF and VEGF-C is different among laryngeal carcinoma, cutting edge and normal tissue in the same patient. In laryngeal carcinoma, the gene expression of VEGF, VEGF-C were not associated with age, sex, site, T stage and histological grade of differentiation. Expression of VEGF, VEGF-C in laryngeal carcinoma was significantly higher in lymph node positive group than in lymph node negative group.


CONCLUSIONS
VEGF, VEGF-C have prognostic significance in laryngeal carcinoma.
Yang
Yan
Y
Department of Otolaryngology, Shanghai Punan Hospital, Shanghai, 200125.
Ge
Rongming
R
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016228:Endothelial Growth Factors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; D042442:Vascular Endothelial Growth Factors