[Pharmacological correction of emotional stress after exposure to ionizing radiation and treatment with a radioprotector indralin].
A possibility to use tranquilizers (aphobazole, phenazepamum) for reducing symptoms of prolonged emotional stress influencing rats after irradiation under treatment with a radioprotector indralin was investigated. It was found that indralin showed the protective effect and activated regenerative processes in the hemopoietic system of animals exposed to doses of 6.0 and 7.0 Gy. The prolonged emotional stress developing in the early periods after the exposure, essentially reduced the favourable action of the radioprotector on restoration of hemopoiesis. The application of tranquilizers stopped the inhibiting action of the emotional stress on the hemopoietic system of the irradiated animals in conditions of radioprotective administering.
Deshevoĭ
Iu B
IuB
State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia.
Moroz
B B
BB
Seredenin
S B
SB
Lyrshikova
A V
AV
Lebedev
V G
VG
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002588:Cesium Radioisotopes; D003627:Data Interpretation, Statistical; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000503:physiopathology; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D002588:Cesium Radioisotopes; D009025:Morpholines; D010636:Phenols; D011837:Radiation-Protective Agents; D014149:Tranquilizing Agents; C086896:indralin