title: Enteroclysis in adult celiac disease: diagnostic value of specific radiographic features.
abstract: The purpose of this study was to compare the diagnostic accuracy of various radiographic findings at enteroclysis in adult patients with untreated celiac disease. Twenty-seven adult patients underwent enteroclysis because of unspecific intestinal symptoms before definitive biopsy proof of celiac disease. Enteroclysis of 123 subjects with similar clinical presentation, including abdominal pain, diarrhea, occult intestinal bleeding, and weight loss, who had a definitive diagnosis other than celiac disease, served as controls. The radiographic features previously described in the literature as indicative of adult celiac disease (i.e., fold thickening, decrease of jejunal folds, increase of ileal folds, small bowel dilatation, flocculation) were evaluated in blinded fashion in all studies and the subjective likelihood of diagnosis of celiac disease was assessed. Assessing every finding separately, each feature proved to have a high specificity (78-100%) but low sensitivity (19-59%) for celiac disease. Reversal of jejunoileal fold pattern was the single best feature (specificity 100%, 95% CI 97-100%; sensitivity 59%, 95% CI 40-78%); however, combination of criteria enables establishment of the diagnosis of celiac disease quite accurately (specificity 100%, 95% CI 98-100%; sensitivity 78%, 95% CI 58-91%). Reversal of jejunoileal fold pattern as a single finding as well as combination at least three of the following features, i.e., fold thickening, decrease of jejunal folds ("colonization"), increase of ileal folds ("jejunization"), dilatation, and flocculation, make enteroclysis an accurate tool for diagnosis of celiac disease in adult patients with suspected intestinal disease.
authors.affiliation: Department of Radiology and Ludwig Boltzmann Institute for Clinical and Experimental Radiologic Research, University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. friedrich.lomoschitz@univie.ac.at
authors.forename: F
authors.initials: F
authors.lastname: Lomoschitz
authors.forename: W
authors.initials: W
authors.lastname: Schima
authors.forename: E
authors.initials: E
authors.lastname: Schober
authors.forename: K
authors.initials: K
authors.lastname: Turetschek
authors.forename: A
authors.initials: A
authors.lastname: Kaider
authors.forename: H
authors.initials: H
authors.lastname: Vogelsang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002446:Celiac Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging; D007583:Jejunum / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D011859:Radiography; D012680:Sensitivity and Specificity