[Glycopolymers of microorganisms as a source for creation of ecologically-safe antimicrobial media with specific activity].
Current data concerning structure components of the surface of microorganisms which take direct part in manifestation of their adhesive properties--adhesin, on the one hand, and carbohydrate components of cell receptors, on the other hand, are presented and analyzed in the paper. The prevention or decrease of adhesion by means of competitive inhibition by substances, which enclose structure, analogues of adhesins or their receptors, make up promising trend in the system of treatment and prophylaxis of infectious diseases. The use of synthetic substance of directed action will allow ceasing the development of infectious process without additional chemical loading of the organism-host and pollution of the environment, since as to their structure they resemble biomolecules typical of this organism. It is asummed that the data on the microorganism surface components can serve a basis for conducting fundamental investigations concerning relations between the structure and function of natural biopolymers, specification of phylogenetic relations between certain groups of microorganisms as well as for defining the mechanisms of the action and further perfection of probiotics.
Korobkova
K S
KS
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
D018829:Adhesins, Bacterial / Q000187:drug effects; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects / Q000502:physiology; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control; D004463:Ecology; D006003:Glycogen / Q000737:chemistry*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D010802:Phylogeny; D011108:Polymers; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship
D018829:Adhesins, Bacterial; D000890:Anti-Infective Agents; D037102:Lectins; D011108:Polymers; D011956:Receptors, Cell Surface; D006003:Glycogen