title: Pyothorax-associated T-cell lymphoma: a case report.
abstract: We present a case of pyothorax-associated T-cell lymphoma in which Epstein-Barr virus (EBV) genome is not detected in the tumor cells. An 80-year-old male came to our hospital because of a left chest pain. Chest computed tomography (CT) showed a mass at the lower-dorsal part of the pyothorax wall, which involved the adjacent chest wall. The surgical biopsy specimen showed a predominant infiltration of atypical lymphocytes. Results of immunohistochemical analysis were as follows: CD3+, CD4-, CD8+, CD20-, CD30-, CD45RO+ and CD79a-. We diagnosed this case as a type of peripheral T-cell lymphoma. In situ hybridization using EBV-encoded RNA-1 (EBER-1) did not reveal the positive signals in the nucleus of tumor cells. Polymerase chain reaction (PCR) analysis yielded a negative result for human herpesvirus 8 (HHV8). Radiation therapy at 54 Gy reduced the tumor size by 90%. Visual and hearing disturbances of unknown etiology developed just before the completion of radiotherapy. The symptoms progressively worsened and the patient became bedridden. He died of pneumonia 2 months after the completion of radiotherapy. Autopsy did not reveal abnormalities to which the neurological disturbances were attributable.
authors.affiliation: Department of Internal Medicine, Yokohama Sakaekyosai Hospital, Yokohama, Japan. toshi@yk9.so-net.ne.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hashizume
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Matsushita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016724:Empyema, Pleural / Q000209:etiology* / Q000473:pathology; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D008297:Male