title: Fine needle aspiration cytology of solid papillary carcinoma of the breast. A report of four cases.
abstract: BACKGROUND
  Solid papillary carcinoma of the breast (SPCB) is a distinctive form of papillary carcinoma that tends to occur in older women and usually has a favorable prognosis.
  
  
  METHODS
  We report the cytologic and histologic findings in four cases of SPCB. All but one of the patients were elderly women (mean age, 66 years). Three patients presented with breast masses, and one patient presented with a breast mass and nipple discharge. Cytology demonstrated moderately to highly cellular smears with irregular groups of predominantly monolayered epithelium composed of small, polygonal or cuboidal cells with eosinophilic cytoplasm and rounded, eccentrically placed nuclei. Papillalike clusters with thin, fibrovascular cores were also observed. Immunocytochemical expression of synaptophysin was present in two cases. The diagnosis of SPBC was subsequently confirmed histologically and immunohistochemically.
  
  
  CONCLUSIONS
  The FNA of SPCB displays some features that may be helpful in its correct identification preoperatively.
authors.affiliation: Departamento de Anatomia Patologica, Hospital Universitario La Paz, Paseo de la Castellana, 261, E-28046 Madrid, Spain. dhardisson@hulp.insalud.es
authors.forename: David
authors.initials: D
authors.lastname: Hardisson
authors.forename: Pilar
authors.initials: P
authors.lastname: González-Peramato
authors.forename: Cristian
authors.initials: C
authors.lastname: Perna
authors.forename: Jesús
authors.initials: J
authors.lastname: Cuevas
authors.forename: Jaime
authors.initials: J
authors.lastname: Sánchez-Fernández de la Vega
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000473:pathology*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008327:Mammography; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor