Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.
Tsantrizos
Youla S
YS
Department of Chemistry, Boehringer Ingelheim, Canada, Ltd., Research and Development, 2100 Cunard Street, Laval, PQ H7S 2G5, Canada. ytsantrizos@lav.boehringer-ingelheim.com
Bolger
Gordon
G
Bonneau
Pierre
P
Cameron
Dale R
DR
Goudreau
Nathalie
N
Kukolj
George
G
LaPlante
Steven R
SR
Llinàs-Brunet
Montse
M
Nar
Herbert
H
Lamarre
Daniel
D
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D006528:Carcinoma, Hepatocellular; D016174:Hepacivirus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008099:Liver / Q000166:cytology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000998:Antiviral Agents; D010456:Peptides, Cyclic; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases