Topiramate in the treatment of severe bulimia nervosa with comorbid mood disorders: a case series.
OBJECTIVE
To report observations on the efficacy and tolerability of topiramate in a sample of five patients with severe symptoms of bulimia nervosa and comorbid mood and/or anxiety disorders.


METHODS
Topiramate was added to other psychotropic medication under open-label conditions up to the maximum tolerated dose or until remission of the eating disorder was achieved.


RESULTS
Topiramate almost completely eliminated binging and purging behavior in three of the five patients. Improvement was maintained throughout the period of follow-up for up to 18 months. One patient showed a partial, temporary response, and the fifth was intolerant of the drug and unable to complete an adequate trial.


CONCLUSIONS
These results suggest strongly that the efficacy of topiramate in patients with bulimia nervosa with and without comorbid mood and anxiety disorders should be investigated more fully.
Barbee
James G
JG
Department of Psychiatry, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. jbarbbe@lsuhsc.edu
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002032:Bulimia / Q000188:drug therapy* / Q000523:psychology; D002908:Chronic Disease; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D000077236:Topiramate; D016896:Treatment Outcome
D000077236:Topiramate; D005632:Fructose