Selective serotonin reuptake inhibitor usage patterns as risk factors for hospitalization.
The authors examined how differences in SSRI utilization affect the risk of hospitalization among persons with depression. In particular, they decompose how different types of drug therapy affect hospitalization and how that effect varies with the usage pattern of the drug. Using retrospective medical and pharmacy claims from a Midwestern health maintenance organization, they employed multiple logistic regression analyses of patients newly treated for depression. Their findings were that (a) paroxetine may be a significant risk factor for early discontinuation compared with fluoxetine; and (b) sertraline initiation among stable-use patients may lower the risk of hospitalization. However, initiation on paroxetine or sertraline rather than fluoxetine may increase the risk of hospitalization among patients not exhibiting a stable usage pattern.
Sheffield
Reinée E
RE
PCS Health Systems, Scottsdale, AZ, USA.
Lo Sasso
Anthony T
AT
Young
Christopher H
CH
Way
Karen
K
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D017723:Drug Utilization Review; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use; D006279:Health Maintenance Organizations; D006760:Hospitalization; D006801:Humans; D008485:Medical Audit; D015146:Midwestern United States; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline