title: Synthesis and biological properties of S-adamantylated heterocyclic compounds.
abstract: A series of new S-adamantylated compounds were prepared by adamanlyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-alpha in genetically modified mouse melanoma cells is presented.
authors.affiliation: Institute of Chemistry, Agricultural University, 159C Nowoursynowska Str., 02-787 Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Górska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Switaj
authors.forename: Izabela
authors.initials: I
authors.lastname: Młynarczukh
authors.forename: Witold
authors.initials: W
authors.lastname: Lasek
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kazimierczuk
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D014409:Tumor Necrosis Factor-alpha; D000218:Adamantane