title: Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils.
abstract: Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the seizure prone gerbil hippocampus after treating VGB were investigated to identify the effect of VGB on energy and/or glutamate metabolism via GDH. In the VGB treated group, GDH immunoreactivity and its activity in the hippocampus were significantly decreased, as compared with those of controls. These findings suggest that VGB administration may suppress the development and spread of seizures not only by elevating the level of GABA, but also by affecting the glutamate signaling and energy metabolism in neurons.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea. tckang@hallym.ac.kr
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Oh-Shin
authors.initials: OS
authors.lastname: Kwon
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005849:Gerbillinae; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology; D012640:Seizures / Q000188:drug therapy / Q000201:enzymology*; D020888:Vigabatrin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004791:Enzyme Inhibitors; D005969:Glutamate Dehydrogenase; D020888:Vigabatrin