Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.
Interleukin 10 (IL10) is a powerful Th-2 cell cytokine produced by lymphoid cells that exerts its functions by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFA, TGFB, IL6, IL8 and IL12). Genetic association analysis of a well-characterized HBV cohort revealed that one of IL10 haplotypes, IL10-ht2, was strongly associated with hepatocellular carcinoma (HCC) occurrence in gene dose-dependent manner. The frequency of susceptible IL10-ht2 was much higher in HCC patients and significantly increased in order of susceptibility to HBV progression from chronic hepatitis to liver cirrhosis and HCC among hepatitis B patients. In addition, survival analysis clearly showed that the onset age of HCC was also accelerated among chronic hepatitis B patients who were carrying IL10-ht2. Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-Gu, Seoul 110-834, Korea.
Park
Byung Lae
BL
Kim
Lyoung Hyo
LH
Jung
Ji Hyun
JH
Kim
Jun Yeon
JY
Yoon
Jung Hwan
JH
Kim
Yoon Jun
YJ
Lee
Hyo-Suk
HS
D017668:Age of Onset; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D006239:Haplotypes; D019694:Hepatitis B, Chronic / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D016019:Survival Analysis
D016753:Interleukin-10