Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald's protocol: a short route to linezolid and toloxatone.
[reaction: see text] Coupling of a variety of substituted aryl bromides with oxazolidinones has been achieved using the Buchwald protocol for the amidation of aryl halides. This procedure is exemplified by the synthesis of two medicinally important molecules, linezolid and toloxatone.
Mallesham
B
B
Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad-500 050, India.
Rajesh
B M
BM
Reddy
P Rajamohan
PR
Srinivas
D
D
Trehan
Sanjay
S
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D000069349:Linezolid; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000081:Acetamides; D001965:Bromides; D007454:Iodides; D023303:Oxazolidinones; C010798:toloxatone; D003300:Copper; C073870:cuprous iodide; D000069349:Linezolid