Mechanism of inhibition of novel COX-2 inhibitors.
Gierse
James
J
Monsanto/Searle Discovery Research, Chesterfield, Missouri 63198, USA.
Kurumbail
Ravi
R
Walker
Mark
M
Hood
Bill
B
Monahan
Joe
J
Pawlitz
Jennifer
J
Stegeman
Rick
R
Stevens
Anna
A
Kiefer
Jim
J
Koboldt
Carol
C
Moreland
Kirby
K
Rowlinson
Scott
S
Marnett
Larry
L
Pierce
Jennifer
J
Carter
Jeff
J
Talley
John
J
Isakson
Peter
P
Seibert
Karen
K
D000068579:Celecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D007555:Isoxazoles / Q000494:pharmacology; D007700:Kinetics; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000494:pharmacology; D013997:Time Factors; D000096926:Benzenesulfonamides
D000068579:Celecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007555:Isoxazoles; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D011994:Recombinant Proteins; D013449:Sulfonamides; C115461:SC 560; C406224:valdecoxib; D000096926:Benzenesulfonamides; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human