title: Effect of a single drop of latanoprost on intraocular pressure and blood-aqueous barrier permeability in patients with uveitis.
abstract: The purpose of our study is to evaluate the effect of a single drop of latanoprost on the intraocular pressure and blood-aqueous barrier permeability in 8 patients with uveitis. The degree of inflammation was determined by the intensity of aqueous flare measured with a laser flare cell meter every 2 hours from 11:00 to 17:00 hours for 2 days. Intraocular pressure was measured at 11:00 and 17:00 hours with a Goldmann applanation tonometer on both days. Patients were given one drop of 0.005% latanoprost at 11:00 hours on day 2 and results were compared with day 1 when latanoprost was not administered. There was no significant difference in the intensity of aqueous flare or intraocular pressure between day 1 and day 2. A single drop of latanoprost had little effect on intraocular pressure and aqueous flare intensity in patients with uveitis.
authors.affiliation: Department of Ophthalmology, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan. ykiuchi@onh.go.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: Koji
authors.initials: K
authors.lastname: Okada
authors.forename: Nami
authors.initials: N
authors.lastname: Ito
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Kanae
authors.initials: K
authors.lastname: Fukui
authors.forename: Takako
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ishimoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D018916:Blood-Aqueous Barrier / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012494:Sampling Studies; D012720:Severity of Illness Index; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost