Plasma-associated halogenated phenolic contaminants in benthic and pelagic fish species from the Detroit River.
Halogenated phenolic contaminants (HPCs), polychlorinated biphenyls (PCBs), and other organochlorine (OC) contaminants (DDTs, chlordanes, HCH, and octachlorostyrene (OCS)) were determined (ng/g, wet wt basis) in the blood plasma of 6 piscivorous/pelagic- and 7 benthic-feeding fish species from the Detroit River. Seven to twelve hydroxylated (OH) PCB congeners with pentachloro- to nonachloro-substitution, pentachlorophenol (PCP) and 4-OH-heptachlorostyrene (4-OH-HpCS), as well as a number of other unidentified HPCs, were detected in all the fish species studied. The concentrations of sigma-OH-PCB (0.57-129.5 ng/ g), 4-OH-HpCS (0.02-0.31 ng/g), and PCP (0.05-3.42 ng/ g) in comparison to other major polychlorinated contaminants (sigma-PCB (10.4-909.0 ng/g), sigma-chlordane (0.72-8.68 ng/g), sigma-DDT (2.10-66.57 ng/g), and sigma-HCH (0.04-0.84 ng/g)) demonstrate the importance of HPCs, especially OH-PCBs, as plasma-associated contaminants. OH-PCBs are most likely metabolites of PCBs, and 4-OH-HpCS is a likely metabolite of OCS. Our findings indicate that metabolic biotransformation is a factor in the bioaccumulation, pharmacokinetics, and fate of OCS and highly chlorinated PCB congeners that are generally more recalcitrant in fish. Target tissue exposure to circulating OH-PCBs was variable, and thus potential OH-PCB-mediated toxicological activity and effects (e.g., endocrine-related) and health risks are different among the fish species.
Li
Hongxia
H
Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada.
Drouillard
Ken G
KG
Bennett
Erin
E
Haffner
G Douglas
GD
Letcher
Robert J
RJ
D000818:Animals; D001711:Biotransformation; D004784:Environmental Monitoring; D005399:Fishes; D020387:Food Chain; D006114:Great Lakes Region; D006801:Humans; D007306:Insecticides / Q000378:metabolism / Q000493:pharmacokinetics*; D010636:Phenols / Q000378:metabolism / Q000493:pharmacokinetics*; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000493:pharmacokinetics*; D011634:Public Health; D018570:Risk Assessment; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics*
D007306:Insecticides; D010636:Phenols; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls