title: [Pancreastatin secretion stimulation in healthy volunteers].
abstract: According to animal studies pancreastatin (PST), a peptide that is secreted by numerous neroendocrine cells, inhibits insulin secretion and has a hyperglycaemic and glycogenolytic effect. However, physiologic role of PST in carbohydrate metabolism remains unclear. In order to determine the best stimulus of PST secretion, four different stimulations of GI tract were carried out in 10 healthy volunteers: oral glucose loading test, intravenous glucose loading test, intravenous glucagon infusion and standard meal loading test. Serum PST concentration was measured radioimmunologically at established intervals after each stimulation. It was found that either oral or intravenous glucose loading test do not increase serum PST concentration; intravenous glucagon infusion decreases serum PST concentration and a standard meal increases serum PST concentration.
authors.affiliation: Katedra i Klinika Gastroenterologii i Chorób Przemiany Materii AM w Warszawie.
authors.forename: Edyta
authors.initials: E
authors.lastname: Zagórowicz
authors.forename: Marianna
authors.initials: M
authors.lastname: Bak
authors.forename: Jolanta
authors.initials: J
authors.lastname: Siemińska
authors.forename: Jacek
authors.initials: J
authors.lastname: Muszyński
mesh_terms: D000328:Adult; D015992:Body Mass Index; D053379:Chromogranin A; D002149:Energy Intake; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010187:Pancreatic Hormones / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
chemical_list: D053379:Chromogranin A; D010187:Pancreatic Hormones; C050836:pancreastatin; D005934:Glucagon