Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber.
We have developed an ultrahigh-resolution optical coherence tomographic system in which broadband continuum generation from a photonic crystal fiber is used to produce high longitudinal resolution. Longitudinal resolution of 1.3-microm has been achieved in a biological tissue by use of continuum light from 800 to 1400 nm. The system employed a dynamic-focusing tracking method to maintain high lateral resolution over a large imaging depth. Subcellular imaging is demonstrated.
Wang
Yimin
Y
Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA.
Zhao
Yonghua
Y
Nelson
J S
JS
Chen
Zhongping
Z
Windeler
Robert S
RS
D000818:Animals; D004867:Equipment Design; D005240:Feasibility Studies; D007814:Larva / Q000166:cytology; D008962:Models, Theoretical; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*; D014981:Xenopus / Q000254:growth & development