Antibacterial evaluation of cnicin and some natural and semisynthetic analogues.
Some ester derivatives of salonitenolide have been prepared from cnicin, a germacranolide sesquiterpenoid. The compounds were tested for their antibacterial activity. The 8,15-diesters showed a good activity, comparable with that of cnicin. The 15-monoester compounds were not very active showing that esterification at the C-8 position is an important structural feature for antibacterial properties.
Bruno
Maurizio
M
Rosselli
Sergio
S
Maggio
Antonella
A
Raccuglia
Rosa Angela
RA
Napolitano
Francesco
F
Senatore
Felice
F
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D031179:Centaurea; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D028321:Plant Preparations; D012717:Sesquiterpenes; C012849:cnicin