title: Carboxymethylcellulose coated on visceral face of polypropylene mesh prevents adhesion without impairing wound healing in incisional hernia model in rats.
abstract: Adhesions between viscera and mesh may result in intestinal obstruction and fistulae formation. Fewer adhesions with sodium carboxymethylcellulose (SCMC)-coated polypropylene mesh (PM) has been reported, but impaired wound healing was the major concern. We investigated the adhesion-prevention effect of SCMC in different concentrations, as coating only on visceral face of PM and its effects on wound healing. A full-thickness abdominal wall defect was created in 28 rats, which were then divided into three groups. In Group I (control), the defect was repaired with PM only; in Group II and Group III, the defects were repaired with 1% and 1.6% SCMC-coated-PM, respectively. All animals were sacrificed at day 30, and histological evaluation and adhesion scoring were done. Animals in the group in which 1.6% SCMC-coated PM was used developed significantly fewer adhesions compared with other animals (P=0.04). Histological evaluation using a semiquantitative scoring system showed no difference between the groups in fibrosis and inflammation scores (P=0.9 and P=0.3, respectively), and thickness of fibrosis on mesh was also similar (P=0.5). SCMC in 1.6% concentration as coating only on the visceral face of PM reduced the incidence and severity of adhesions without impairing wound healing.
authors.affiliation: Kocaeli Medical School Department of Surgery, University of Kocaeli, Kocaeli Derince Izmit, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Yelimlieş
authors.forename: A
authors.initials: A
authors.lastname: Alponat
authors.forename: A
authors.initials: A
authors.lastname: Cubukçu
authors.forename: M
authors.initials: M
authors.lastname: Kuru
authors.forename: S
authors.initials: S
authors.lastname: Oz
authors.forename: C
authors.initials: C
authors.lastname: Erçin
authors.forename: N
authors.initials: N
authors.lastname: Gönüllü
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D005260:Female; D006555:Hernia, Ventral / Q000601:surgery*; D007813:Laparotomy / Q000379:methods*; D008297:Male; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012680:Sensitivity and Specificity; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014945:Wound Healing / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D011126:Polypropylenes; D002266:Carboxymethylcellulose Sodium