title: The impact of Asian descent on the incidence of acquired severe aplastic anaemia in children.
abstract: Previous studies have suggested an increased incidence of acquired severe aplastic anaemia in Asian populations. We evaluated the incidence of aplastic anaemia in people of Asian descent, using a well-defined paediatric (0-14 years) population in British Columbia, Canada to minimize environmental factors. The incidence in children of East/South-east Asian descent (6.9/million/year) and South Asian (East Indian) descent (7.3/million/year) was higher than for those of White/mixed ethnic descent (1.7/million/year). There appeared to be no contribution by environmental factors. This study shows that Asian children have an increased incidence of severe aplastic anaemia possibly as a result of a genetic predisposition.
authors.affiliation: Oncology Department, The Children's Hospital, Westmead, New South Wales, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: McCahon
authors.forename: Keith
authors.initials: K
authors.lastname: Tang
authors.forename: Paul C J
authors.initials: PC
authors.lastname: Rogers
authors.forename: Mary L
authors.initials: ML
authors.lastname: McBride
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Schultz
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000208:ethnology*; D001208:Asia / Q000208:ethnology; D001955:British Columbia; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Tests; D008297:Male; D017678:Sex Distribution