title: Effect of cigarette smoking on airway responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
abstract: OBJECTIVE
  The objective of this study was to determine differences in airway responsiveness to adenosine 5'-monophosphate (AMP) between smokers and nonsmokers with allergic rhinitis.
  
  
  METHODS
  A total of 41 adults with allergic rhinitis (16 smokers and 25 nonsmokers) were challenged with increasing concentrations of methacholine and AMP. Airflow was assessed after each concentration, and the response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall in FEV(1) (PC(20)).
  
  
  RESULTS
  The geometric mean PC(20) AMP values were significantly lower in smokers than in nonsmokers: 72.4 mg/mL (95% confidence interval [CI], 33.9 to 154.9) vs 204.2 mg/mL (95% CI, 120.2 to 346.7) [p = 0.021]. The proportion of subjects with bronchoconstriction in response to AMP was higher in smokers (12 of 16 subjects) than in nonsmokers (7 of 25 subjects) [p = 0.005].
  
  
  CONCLUSIONS
  We conclude that smokers with allergic rhinitis have a greater AMP sensitivity than nonsmokers.
authors.affiliation: Sección de Alergología and Universidad de Valencia, Spain. prieto_jes@gva.es
authors.forename: Luis
authors.initials: L
authors.lastname: Prieto
authors.forename: Valentina
authors.initials: V
authors.lastname: Gutiérrez
authors.forename: Sonia
authors.initials: S
authors.lastname: Uixera
authors.forename: J Manuel
authors.initials: JM
authors.lastname: Bertó
mesh_terms: D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000328:Adult; D001980:Bronchi / Q000187:drug effects* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D012221:Rhinitis, Allergic, Perennial / Q000503:physiopathology*; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D012907:Smoking / Q000503:physiopathology*; D013147:Spirometry
chemical_list: D000249:Adenosine Monophosphate