New insights into endothelial diversity.
It has long been appreciated that endothelium from distinct vascular beds manifest diverse structural and functional properties. With current technologies, we have begun to systematically define the unique molecular profiles that orchestrate and sustain this diversity, and to assess the influences of various environmental and developmental stimuli on these processes. This review focuses on recent advances and findings that provide insights into both the extent and causes of endothelial cell diversity.
Tomlinson
James E
JE
Millennium Pharmaceuticals, Inc., 256 East Grand Avenue, South San Francisco, CA 94080, USA. Jamie.Topper@mpi.com
Topper
James N
JN
D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology*; D005821:Genetic Techniques; D014644:Genetic Variation / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D014652:Vascular Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*