title: Correlation among retinal thickness, optic disc, and visual field in glaucoma patients and suspects: a pilot study.
abstract: OBJECTIVE
  To correlate losses of retinal thickness in the perifoveal area in glaucoma as measured by the Retinal Thickness Analyzer (Talia Technology Ltd, Israel) with optic nerve and visual field changes in glaucoma patients and suspects.
  
  
  METHODS
  Observational case series of 55 consecutive patients from the Glaucoma Service who either presented with a diagnosis of glaucoma or were referred for evaluation of suspected glaucoma. The Retinal Thickness Analyzer (Talia Technology, Ltd.) was used to obtain retinal thickness maps. Retinal thickness analysis, visual field testing, and stereophotography of the optic nerve head were performed, and a glaucoma specialist who was masked to patient status and identity data randomly graded the level of severity of each parameter. Spearman rank correlations were used to assess the relationships among the three numerical measures.
  
  
  RESULTS
  Retinal thickness losses correlated more strongly with severity of optic nerve head cupping (r = 0.75), whereas both of these measures correlated less strongly with the severity of visual field loss (r = 0.54).
  
  
  CONCLUSIONS
  Retinal thickness measurements at the posterior pole provide another measure of neural loss in glaucoma, and may help in the clinical assessment of optic nerve cupping. However, there are limitations of the technology that must be considered.
authors.affiliation: Glaucoma Service, Duke University Eye Center, Durham, North Carolina 27710, USA. astran002@mc.duke.edu
authors.forename: Sanjay
authors.initials: S
authors.lastname: Asrani
authors.forename: Pratap
authors.initials: P
authors.lastname: Challa
authors.forename: Leon
authors.initials: L
authors.lastname: Herndon
authors.forename: Paul
authors.initials: P
authors.lastname: Lee
authors.forename: Sandra
authors.initials: S
authors.lastname: Stinnett
authors.forename: R Rand
authors.initials: RR
authors.lastname: Allingham
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010781:Photography; D010865:Pilot Projects; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology; D058609:Visual Field Tests; D014794:Visual Fields