Severe chronic sensory-motor polyneuropathy: coexistence of 3 unrelated etiologies in a type 1 diabetic patient. A case report and review of the literature.
We present the case of a 58-year-old man, who has suffered from type 1 diabetes mellitus since he was young. He had monoclonal IgM kappa gammopathy of undetermined significance and high anti-MAG antibody titer. He developed a polyneuropathic picture with the clinical and laboratory features of chronic inflammatory demyelinating polyneuropathy within the span of approximately 2 years. He benefited from IV administration of high doses of immunoglobulins. Investigation of all parameters, but particularly of the clinical phenotype, can lead to a better definition of the polyneuropathic picture, especially for therapeutic and prognostic purposes.
Micco
Andrea
A
Department of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy. Nereo.Bresolin@Unimi.it
Nobile-Orazio
Eduardo
E
Baron
Pierluigi
P
Conti
Giancarlo
G
Napoli
Laura
L
Serafini
Massimo
M
Scarlato
Guglielmo
G
Scarpini
Elio
E
D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000473:pathology; D003929:Diabetic Neuropathies / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000209:etiology* / Q000473:pathology