The importance of in-hospital statin therapy for patients with acute coronary syndromes.
Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with ACS after hospital admission is associated with an increased risk of adverse outcomes. Recent non-ST elevation ACS guidelines recommend beginning statin therapy, along with dietary intervention, in patients whose low-density lipoprotein cholesterol levels exceed 130 mg/dl within 24-96 hours after hospital admission. Various strategies have been developed to aid in the implementation of in-hospital lipid-lowering therapy. Pharmacists can play a valuable role in optimizing drug therapy for dyslipidemia and ensuring long-term adherence.
Paradiso-Hardy
Fran L
FL
Department of Pharmacy, Sunnybrook and Women's College Health Sciences Centre, Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Gordon
Wendy L
WL
Jackevicius
Cynthia A
CA
Kertland
Heather R
HR
Pearson
Glen J
GJ
Pickering
Jennifer L
JL
Poirier
Luc
L
Semchuk
Bill M
BM
Verret
Lucie
L
D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy; D013577:Syndrome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors