title: [Brain irradiation and phenytoin: a dangerous liaison?].
abstract: Three patients are presented, who developed a severe skin reaction after brain-irradiation and concomitant phenytoin treatment. A fourth patient from the databAse of the Swiss Drug Monitoring Center, showed a Stevens-Johnson-Syndrome after a severe electric shock and phenytoin treatment. Possible pathogenic mechanisms of these life-threatening complications and possible alternatives to the phenytoin treatment in irradiated patients are discussed.
authors.affiliation: Departement Innere Medizin, Kantonsspital Chur.
authors.forename: C
authors.initials: C
authors.lastname: Camartin
authors.forename: W H
authors.initials: WH
authors.lastname: Reinhart
authors.forename: M
authors.initials: M
authors.lastname: Kuhn
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin