Singlet oxygen-induced signaling effects in mammalian cells.
Singlet oxygen, an electronically excited form of molecular oxygen, may be generated photochemically or in dark reactions in vivo. Singlet oxygen is not only toxic to cells and impairs signaling events but is also capable of eliciting a cellular stress response. The signaling processes initiated in this response include the activation of mitogen-activated protein kinases. Two possible activation mechanisms of signaling pathways by singlet oxygen are the generation of positive regulators as well as the inactivation of negative regulators.
Klotz
Lars-Oliver
LO
Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, D-40225 Düsseldorf, Germany. LarsOliver.Klotz@uni-duesseldorf.de
Kröncke
Klaus-Dietrich
KD
Sies
Helmut
H
D000818:Animals; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000187:drug effects / Q000378:metabolism; D009603:Nitroso Compounds / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction; D010777:Photochemistry; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D026082:Singlet Oxygen / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D016335:Zinc Fingers
D009603:Nitroso Compounds; D011506:Proteins; D026082:Singlet Oxygen; D020928:Mitogen-Activated Protein Kinases