title: Hepatocellular carcinoma in a patient with primary biliary cirrhosis and seronegativity for markers of hepatitis B virus and hepatitis C virus: report of a case.
abstract: We report a case of hepatocellular carcinoma (HCC) arising in a patient with primary biliary cirrhosis (PBC) in whom both hepatitis B virus (HBV) and hepatitis C virus (HCV) serological tests were negative. A 72-year-old woman was found to have HCC 10 years after a diagnosis of PBC. All serological tests for HBV and HCV were negative. Preoperative liver biopsy findings suggested moderately differentiated HCC. Dynamic computed tomography (CT) showed hypervascular tumors in segments IV and VII. At laparotomy, a 30-mm tumor was palpated in segment VII and a wedge resection was performed. The second tumor, which measured 10 mm in diameter, was detected in segment IV by abdominal ultrasound, and microwave coagulation therapy was done. HCC arising in hepatitis virus marker-negative PBC is rare and past reports do not clarify whether HBV or HCV infections are associated with HCC.
authors.affiliation: Department of Surgery, Okinawa Prefectural Northern Hospital, 2-12-3 Oonaka Nago, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sunagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayama
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Yamashiro
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sashida
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuura
authors.forename: Munefumi
authors.initials: M
authors.lastname: Kayou
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis*; D006526:Hepatitis C / Q000175:diagnosis*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis; D012698:Serologic Tests