title: [Molecular mechanisms behind the immunological reaction against gluten in patients with celiac disease].
abstract: Coeliac disease is a complex inflammatory disorder of the small intestine, induced by dietary gluten in genetically susceptible individuals. Recently, the nature of gluten-derived peptides recognized by gut-derived T cells from patients has been elucidated. It has further been established that the binding of such peptides to HLA-DQ2 and DQ8 molecules is enhanced following the modification of the peptides by the ubiquitous enzyme tissue transglutaminase. This knowledge has allowed the establishment of a molecular basis for the well-known association between coeliac disease and the expression of these HLA-molecules. This article summarizes the latest progress in coeliac disease molecular biology.
authors.affiliation: Odense Universitetshospital, Klinisk Immunologisk Afdeling, Paediatrisk Afdeling.
authors.forename: Christian
authors.initials: C
authors.lastname: Nielsen
authors.forename: Steffen
authors.initials: S
authors.lastname: Husby
authors.forename: Søren T
authors.initials: ST
authors.lastname: Lillevang
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000235:genetics; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007421:Intestine, Small / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens; D005983:Glutens