title: Digoxin-like immunoreactive substance in nonoliguric hyperkalemia of the premature infant.
abstract: Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.
authors.affiliation: Department of Pediatrics, Universitätsklinikum Benjamin Franklin, Berlin, Germany. eva.mildenberger@ukbf.fu-berlin.de
authors.forename: Eva
authors.initials: E
authors.lastname: Mildenberger
authors.forename: Kathrin
authors.initials: K
authors.lastname: Oels
authors.forename: Karl
authors.initials: K
authors.lastname: Bauer
authors.forename: Martin
authors.initials: M
authors.lastname: Paul
authors.forename: Hans T
authors.initials: HT
authors.lastname: Versmold
mesh_terms: D002298:Cardenolides; D002940:Circadian Rhythm; D004077:Digoxin / Q000097:blood / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D007231:Infant, Newborn; D007424:Intracellular Fluid / Q000378:metabolism; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D012503:Saponins / Q000097:blood / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium