Death and NF-kappaB in T cell activation: life at the edge.
Nuclear Factor kappa-B appears to be required to prevent p73-induced apoptosis triggered by primary T cell activation. Here we explore what this state of affairs might do for the regulation of the immune system.
Green
Douglas R
DR
La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
D000818:Animals; D017209:Apoptosis; D016923:Cell Death; D004268:DNA-Binding Proteins / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D006801:Humans; D008213:Lymphocyte Activation; D016328:NF-kappa B / Q000378:metabolism / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins