Cognitive inhibition and thought disorder in schizophrenia.
In schizophrenia, inhibitory control is reported to be disturbed and has been associated with formal thought disorder (TD). The negative priming task (NP) is used as a measure for inhibition; however, controversial results are found in the literature. The aim of this study was to evaluate cognitive inhibition in schizophrenia and TD. Additionally, the influence of the course of disease and of medication were evaluated. The NP was used to compare TD patients (n = 17) with non-TD (n = 19) and healthy controls (n = 21). Results showed similar performance among TD and non-TD patients, and controls. No influence of the course of disease or medication was found. Our results are in line with recent studies, where patients, irrespective of TD, show normal performance in the NP.
Roesch-Ely
Daniela
D
Department of Psychiatry, University of Heidelberg, Heidelberg, Germany. daniela_roesch@med.uni-heidelberg.de
Spitzer
Manfred
M
Weisbrod
Matthias
M
D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D010054:Brief Psychiatric Rating Scale; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D013850:Thinking
D014150:Antipsychotic Agents