title: Long-term benzimidazole treatment of alveolar echinococcosis with hematogenic subcutaneous and bone dissemination.
abstract: We report a case of advanced alveolar echinococcosis (AE) that presented like a malignant tumor. It was diagnosed histologically from a subcutaneous nodule with skin inflammation on the right leg. Additionally, the patient showed bone metastases in the lower thoracic spine and the left third toe. This is the first case with proven hematogenic spread of AE to a subcutaneous site. The patient was treated with albendazole and remained stable for 6 years. When progression of AE occurred the therapy was changed to mebendazole, resulting in a stable condition for further 4 years.
authors.affiliation: Department of Hematology, Oncology, Infectious Diseases and Rheumatology, J. W. Goethe University Hospital, Theodor Stern Kai 7, 60596 Frankfurt, Germany. scheuring@em.uni-frankfurt.de
authors.forename: Urban J
authors.initials: UJ
authors.lastname: Scheuring
authors.forename: Hanns Martin
authors.initials: HM
authors.lastname: Seitz
authors.forename: Axel
authors.initials: A
authors.lastname: Wellmann
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Hartlapp
authors.forename: Dennis
authors.initials: D
authors.lastname: Tappe
authors.forename: Klaus
authors.initials: K
authors.lastname: Brehm
authors.forename: Ulrich
authors.initials: U
authors.lastname: Spengler
authors.forename: Tilmann
authors.initials: T
authors.lastname: Sauerbruch
authors.forename: Jürgen K
authors.initials: JK
authors.lastname: Rockstroh
mesh_terms: D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use; D000923:Anticestodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D001850:Bone Diseases, Infectious / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis; D018512:Parasitemia / Q000188:drug therapy; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology
chemical_list: D000923:Anticestodal Agents; D001562:Benzimidazoles; D008463:Mebendazole; D015766:Albendazole