title: [Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease].
abstract: OBJECTIVE
  To examine the distribution of 3 polymorphisms of lecithin cholesterol acyltransferase gene in Chinese population and the association of these polymorphisms with lipid metabolism in patients with atherosclerotic heart disease (CHD).
  
  
  METHODS
  Genotypes and frequencies of 3 sites were examined by PCR-restriction fragment length polymorphism technique in 209 unrelated normal control individuals and 203 CHD patients.
  
  
  RESULTS
  The observed allele frequencies conform well to Hardy-Weinberg equilibrium. The frequency of 608T allele was significantly higher in controls than that in patients (P=0.034). Compared with the CHD patients without 608T, the CHD patients with 608T exhibited a significant increase in plasma HDL-C concentration (P=0.015). 911T/C and 1188C/T polymorphisms were not found in either group.
  
  
  CONCLUSIONS
  608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in CHD patients, while 911T/C and 1188C/T polymorphisms maybe very rare in Chinese population.
authors.affiliation: Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. szzhang@mcwcums.com
authors.forename: Kelan
authors.initials: K
authors.lastname: Zhang
authors.forename: Sizhong
authors.initials: S
authors.lastname: Zhang
authors.forename: Keqin
authors.initials: K
authors.lastname: Zheng
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jiajun
authors.initials: J
authors.lastname: Shi
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Kong
authors.forename: Yu
authors.initials: Y
authors.lastname: Tong
mesh_terms: D000483:Alleles; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003324:Coronary Artery Disease / Q000201:enzymology / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D014280:Triglycerides; D004247:DNA; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D004262:DNA Restriction Enzymes