Cell Interferon Sensitivity in Immunodeficiencies, Autoimmune and Allergic Diseases.
Novel approach is suggested to study interferon (IFN) system state in various immunopathological disorders. It is based upon measurement of IFN-alpha and/or IFN-gamma production by leukocytes primed with IFN-alpha or IFN-gamma respectively. Study of IFN-status parameters revealed a tendency to decrease in the induced IFN-alpha production in patients with secondary immune deficiency (SID), autoimmune syndrome (AIS), allergic diseases, lymphoadenopathy (LAP), chronic bronchitis (CB) and bronchial asthma (BAS). Production of the induced IFN-gamma was significantly depressed in all groups except LAP. In priming conditions production of IFN-alpha by leukocytes of the patients with SID, AIS, allergic diseases and LAP increased 1.27-fold (p < 0.02), 1.31-fold (p < 0.1), 1.31-fold (p < 0.001) and 1.27-fold (p < 0.05), respectively. Under the same conditions production of IFN-gamma by leukocytes of the patients with SID, AIS, allergic diseases, LAP and BAS increased 1.69-fold (p < 0.001), 2.42-fold (p < 0.01), 1.63-fold (p < 0.001), 1.4-fold (p < 0.1) and 1.69-fold (p < 0.05), respectively. The data obtained may be useful for understanding mechanisms of the IFN system deficiency development in immunopathological disorders, as well as for further development and improvement of IFN therapy.
Narovlyansky
Alexander N.
AN
Gamaleya Institute for Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia.
Amchenkova
Alevtina M.
AM
Mezentseva
Marina V.
MV
Sanin
Alexander V.
AV
Ershov
Felix I.
FI