title: [Iron supplementation associated with malaria prevention among pregnant women in Abidjan].
abstract: BACKGROUND
  Despite the demonstrated efficacy of iron supplements and malaria prevention, the effectiveness of antenatal care programs for prevention of anaemia (haemoglobin rate<11 g/dL) in pregnant women is low in West Africa. Apart from the issue of availability and despite low cost, the major reason evoked is the lack of motivation of pregnant women and health care professionals. In this study, iron supplements and malaria prophylactics were provided free of charge during pregnancy. The treatment was proposed at the first antenatal visit, with the objective of not interfering with routine practice of birth attendants and women in latter antenatal visits.
  
  
  METHODS
  Haemoglobin rates were measured and Plasmodium falciparum tested for among pregnant women in four maternity units in Abidjan. The tests were carried out at inclusion during the first antenatal visit and during immediate post-partum in 631 pregnant women who delivered in one of the four wards. Considering the objective of the study, compliance was assessed for the month prior to delivery.
  
  
  RESULTS
  Despite an habitual decrease in iron deficiency at the end of pregnancy, haemoglobin rates in the study population increased from 10.4 g/dL at inclusion to 10.9 g/dL during post-partum. Prevalence of anemia consequently decreased from 62.8% to 49.4% (p<0.01). A similar increase of 0.7 g/dL was observed among women stating a regular (57%) or irregular (36.9%) compliance with the protocol. A decrease of 0.4 g/dL (s.t.: 1.8 g/dL) was observed among women stating a lack of compliance with the protocol (5.6%). The prevalence of anaemia according to compliance was consequently 43.1%, 49.7% and 70.1% (p=0.02). Severe anaemia (<8 g/dL) at inclusion was an independent risk factor for post-partum anaemia although a 2.9 g/dL increase (s.t.: 2.0 g/dL) was observed in the latter (p<0.01). However, the 11 g/dL threshold was not reached.
  
  
  CONCLUSIONS
  It is therefore important to reinforce the availability of treatments to prevent anaemia in pregnant women due to their demonstrated efficiency as a part of routine antenatal activities.
authors.affiliation: Projet PASSI, Service de Coopération et d'Action Culturelle, Ambassade de France, 01 BP 1839, 01 Abidjan, Côte d'Ivoire. n.carre@invs.sante.fr
authors.forename: N
authors.initials: N
authors.lastname: Carré
authors.forename: P
authors.initials: P
authors.lastname: Eono
authors.forename: K
authors.initials: K
authors.lastname: Kouakou
authors.forename: J-L
authors.initials: JL
authors.lastname: Duponchel
authors.forename: M
authors.initials: M
authors.lastname: Marquis
authors.forename: K H
authors.initials: KH
authors.lastname: Zahui
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000517:prevention & control*; D000962:Antimalarials / Q000627:therapeutic use; D001291:Attitude of Health Personnel; D002738:Chloroquine / Q000627:therapeutic use; D007560:Cote d'Ivoire / Q000453:epidemiology; D019587:Dietary Supplements; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D016015:Logistic Models; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000517:prevention & control*; D008427:Maternal Health Services / Q000458:organization & administration; D009042:Motivation; D010349:Patient Compliance; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology / Q000517:prevention & control*; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D000962:Antimalarials; D006454:Hemoglobins; D002738:Chloroquine; D007501:Iron