title: Correlation of serum cytokine levels with axial bone mineral density.
abstract: Cytokine has been postulated to play a role in the pathogenesis of post-menopausal osteoporosis. To test this hypothesis we measured circulating levels of IL-1, IL-6,IL-8 and TNF-alpha in 98 post-menopausal women (30 age matched normal and 68 osteoporotic) with no vertebral fractures. Although the cytokine levels of patients were found in normal cut off values, the difference in cytokine levels between patients and controls was statistically significant for IL-1 and IL-8 (p < 0.01). In osteoporotic patients, none of the cytokines correlated with lumbar, femoral (neck) and total hip bone mineral densities and also with body mass index (p > 0.01). In conclusion, we were unable to demonstrate abnormalities of cytokines affecting bone resorption in peripheral serum of women with post-menopausal osteoporosis. However increased production of these cytokines may occur in the local environment of bone.
authors.affiliation: Department of Physical Medicine and Rehabilitation, School of Medicine, University of Mersin, Mersin, Turkey. gunsahsahin@hotmail.com
authors.forename: Gunsah
authors.initials: G
authors.lastname: Sahin
authors.forename: Candan
authors.initials: C
authors.lastname: Ozturk
authors.forename: Selda
authors.initials: S
authors.lastname: Bagis
authors.forename: Ozlem Bolgen
authors.initials: OB
authors.lastname: Cimen
authors.forename: Canan
authors.initials: C
authors.lastname: Erdogan
mesh_terms: D001862:Bone Resorption / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism*; D017698:Postmenopause / Q000502:physiology*
chemical_list: D016207:Cytokines