title: Notch and cancer: best to avoid the ups and downs.
abstract: The Notch pathway is known for its multiple important roles in development and tissue homeostasis, and it can be subverted during oncogenic transformation. Two recent studies add to our understanding of Notch in cancer biology in contrasting ways, by showing novel mechanisms of Notch pathway activation in cancer cells, and by indicating that in some circumstances, Notch can behave as a tumor suppressor.
authors.affiliation: Division of Hematology-Oncology, Institute for Medicine and Engineering, University of Pennsylvania, 611 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. wpear@mail.med.upenn.edu
authors.forename: Ivan
authors.initials: I
authors.lastname: Maillard
authors.forename: Warren S
authors.initials: WS
authors.lastname: Pear
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch