[Clinical efficiency of chemotherapy in primary liver cancer depending on the state of blood coagulation system].
The intraarterial catheter chemotherapy was instituted, its efficiency assessed, in 20 patients with primary carcinoma of the liver. Indices of the coagulogram were studied at admission into hospital and on reaching the end of the treatment. In 6 patients, chemotherapy was combined with anticoagulating therapy. In patients with incipient hypercoagulation, metastasizing was found with higher frequency in a month's time. Chemotherapy proved to aggravate the hyper-coagulation syndrome. Anticoagulant therapy has been shown to lower complication rates, especially where employed with intraarterial chemotherapy.
Pulatov
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DA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000925:Anticoagulants; D004317:Doxorubicin; D005472:Fluorouracil