title: Risk factors and prognosis of anterior commissure versus posterior commissure T1-T2 glottic cancer.
abstract: For better understanding of the causation and behavior of T1-T2 commissural glottic laryngeal tumors, we retrospectively analyzed risk factors and outcome related to T class and type of therapy for tumors involving the anterior (184 cases) or the posterior (60 cases) commissure. The patients' smoking habits and alcohol consumption were similar, regardless of involved subsite. The disease-free interval was longer after surgery than after radiotherapy. The survival rates after recovery upon relapse were similar among subsites, T classes, and types of therapy. In anterior commissure tumors, the larynx remained preserved more frequently after partial laryngeal resection than after radiotherapy, and was more frequently preserved the lower the T class. In posterior commissure tumors, larynx preservation was less frequent and apparently independent of type of therapy or T class. In conclusion, smoking and alcohol consumption play similar pathogenetic roles in either subsite; partial laryngeal resection gave a higher rate of laryngeal preservation than did radiotherapy; and anatomic peculiarities of the subsites influence tumor behavior.
authors.affiliation: Department of Otoneuroophthalmology, Florence University, Florence, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Rucci
authors.forename: Corso
authors.initials: C
authors.lastname: Bocciolini
authors.forename: Paolo
authors.initials: P
authors.lastname: Romagnoli
authors.forename: Jan
authors.initials: J
authors.lastname: Olofsson
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013997:Time Factors