title: Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
abstract: Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.
authors.affiliation: Oxford Centre for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, UK.
authors.forename: Imre
authors.initials: I
authors.lastname: Schlemminger
authors.forename: David R
authors.initials: DR
authors.lastname: Mole
authors.forename: Luke A
authors.initials: LA
authors.lastname: McNeill
authors.forename: Anupma
authors.initials: A
authors.lastname: Dhanda
authors.forename: Kirsty S
authors.initials: KS
authors.lastname: Hewitson
authors.forename: Ya-Min
authors.initials: YM
authors.lastname: Tian
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ratcliffe
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Pugh
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D000613:Aminobutyrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007501:Iron / Q000378:metabolism; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000378:metabolism
chemical_list: D000613:Aminobutyrates; D004791:Enzyme Inhibitors; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007527:Isoenzymes; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C045372:dealanylalahopcin; D007501:Iron; D011393:Procollagen-Proline Dioxygenase