title: Synthesis of spiro diphosphines and their application in asymmetric hydrogenation of ketones.
abstract: Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Shuo-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Fan
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Duan
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou