Glutathione peroxidase activity and serum selenium concentration in intrinsic asthmatic patients.
Serum glutathione peroxidase (GSH-Px) activity and selenium concentration were compared in intrinsic asthmatic patients and non-asthmatic control subjects. Serum GSH-Px activity and selenium concentration were assessed in 46 asthmatic patients and 75 age- and sex-matched non-asthmatic subjects by spectrophotometric assay. Mean serum GSH-Px activity was lower in intrinsic asthmatic subjects (9.4 +/- 2.6 pmol NADPH oxidized/min/g of protein) than in non-asthmatic subjects (16.3 +/- 2.9 pmol NADPH oxidized/min/g of protein). Mean serum selenium was lower in intrinsic asthmatic subjects (1.15 +/- 0.23 microM) than in non-asthmatic subjects (1.98 +/- 0.27 microM). Asthmatic patients have significantly lower concentration of selenium and GSH-Px activity measured in serum.
Qujeq
Durdi
D
Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran. dqujeq@hotmail.com
Hidari
Behzad
B
Bijani
Khezroolla
K
Shirdel
Hosein
H
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009249:NADP / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D012643:Selenium / Q000097:blood*; D013053:Spectrophotometry / Q000379:methods
D009249:NADP; D005979:Glutathione Peroxidase; D012643:Selenium; D010100:Oxygen