Medium chain triglycerides as vehicle for palatable oral liquids.
Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.
Bahal
Surendra M
SM
Pharmaceutical Research & Development, Bristol-Myers Squibb Company, Wilmington, Delaware, USA.
Romansky
Jamie M
JM
Alvarez
Francisco J
FJ
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D006801:Humans; D019999:Pharmaceutical Solutions / Q000008:administration & dosage*; D013649:Taste / Q000187:drug effects* / Q000502:physiology; D014280:Triglycerides / Q000008:administration & dosage*
D004337:Drug Carriers; D019999:Pharmaceutical Solutions; D014280:Triglycerides