title: Nasal-type NK/T cell lymphoma of the orbit with distant metastases.
abstract: A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is reported. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis. Lymphoma cells were positive for CD56, cytotoxic molecules (granzyme B and TIA-1), and EBV. Despite local radiotherapy, the patient had a highly aggressive clinical course. A postmortem examination revealed distant metastases to the heart and lungs exhibiting angiocentric growth. TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit.
authors.affiliation: Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Motomu
authors.initials: M
authors.lastname: Tsuji
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Yoshii
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Kakuno
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Akioka
authors.forename: Takuya
authors.initials: T
authors.lastname: Kotani
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iwao
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001706:Biopsy; D019002:CD56 Antigen / Q000032:analysis; D017809:Fatal Outcome; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D008175:Lung Neoplasms / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis
chemical_list: D019002:CD56 Antigen; D012367:RNA, Viral