Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-kappa paraprotein.
A case is described of B-cell lymphoma/chronic lymphocytic leukaemia associated with membranous glomerulonephritis in which the subepithelial deposits of immunoglobulin showed kappa light chain restriction by immunofluorescence. Surface IgG-kappa immunoglobulin was demonstrated on the malignant B cells, and a monoclonal protein of the same type was eluted from kidney. The mechanism of membranous glomerulonephritis in this type of lymphoid malignancy is clearly different from that in epithelial malignancies.
Evans
David J
DJ
Renal Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. d.j.evans@ic.ac.uk
Macanovic
Momir
M
Dunn
Michael J
MJ
Pusey
Charles D
CD
D000368:Aged; D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007145:Immunoglobulin kappa-Chains / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000473:pathology*; D010266:Paraproteins / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D011655:Pulmonary Embolism / Q000473:pathology
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D010266:Paraproteins