title: Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea.
abstract: Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED(50)=0.02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively).
authors.affiliation: National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C. kuoyh@cma23.nricm.edu.tw
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Kuo
authors.forename: Ang-Su
authors.initials: AS
authors.lastname: Yu
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Chi-Wi
authors.initials: CW
authors.lastname: Ong
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yang Kuo
authors.forename: Jo-Ti
authors.initials: JT
authors.lastname: Huang
authors.forename: Chieh-Fu
authors.initials: CF
authors.lastname: Chen
authors.forename: Shyh-Yuan
authors.initials: SY
authors.lastname: Li
mesh_terms: D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D035741:Vernonia
chemical_list: D003603:Cytotoxins; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes