title: Evidence for asthma susceptibility genes on chromosome 11 in an African-American population.
abstract: Initial genome-wide scan data provided suggestive evidence for linkage of the asthma phenotype in African-American (AA), but not Caucasian, families to chromosome 11q markers (peak at D11S1985; LOD=2). To refine this region, mapping analysis of 91 AA families (51 multiplex families and 40 asthmatic case-parent trios) was performed with an additional 17 markers flanking the initial peak linkage marker. Multipoint analyses of the 51 multiplex families yielded significant evidence of linkage with a peak non-parametric linkage score of 4.38 at marker D11S1337 (map position 68.6 cM). Furthermore, family-based association and transmission disequilibrium tests conducted on all 91 families showed significant evidence of linkage in the presence of disequilibrium for several individual markers in this region. A putative susceptibility locus was estimated to be at map position 70.8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families.
authors.affiliation: Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224-6801, Baltimore, USA, skhuang@jhmi.edu
authors.forename: Shau-Ku
authors.initials: SK
authors.lastname: Huang
authors.forename: Rasika A
authors.initials: RA
authors.lastname: Mathias
authors.forename: Eva
authors.initials: E
authors.lastname: Ehrlich
authors.forename: Beverly
authors.initials: B
authors.lastname: Plunkett
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Garry R
authors.initials: GR
authors.lastname: Cutting
authors.forename: Xin-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Alkis
authors.initials: A
authors.lastname: Togias
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Barnes
authors.forename: Floyd
authors.initials: F
authors.lastname: Malveaux
authors.forename: Stephen
authors.initials: S
authors.lastname: Rich
authors.forename: Beverly
authors.initials: B
authors.lastname: Mellen
authors.forename: Ethan
authors.initials: E
authors.lastname: Lange
authors.forename: Terri H
authors.initials: TH
authors.lastname: Beaty
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D014481:United States; D001741:Black or African American