title: Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia.
abstract: BACKGROUND
  The GRIN1 gene plays a fundamental role in many brain functions, and its involvement in the pathogenesis of the schizophrenia has been widely investigated. Non-synonymous polymorphisms have not been identified in the coding regions. To investigate the potential role of GRIN1 in the susceptibility to schizophrenia, we analyzed the G1001C polymorphism located in the promoter region in a case-control association study.
  
  
  METHODS
  The G1001C polymorphism allele distribution was analyzed in a sample of 139 Italian schizophrenic patients and 145 healthy control subjects by a polymerase chain reaction amplification followed by digestion with a restriction endonuclease.
  
  
  RESULTS
  We found that the C allele may alter a consensus sequence for the transcription factor NF-kappa B and that its frequency was higher in patients than in control subjects (p =.0085). The genotype distribution also was different, with p =.034 (if C allele dominant, p =.0137, odds ratio 2.037, 95% confidence interval 1.1502-3.6076).
  
  
  CONCLUSIONS
  The association reported in this study suggests that the GRIN1 gene is a good candidate for the susceptibility to schizophrenia.
authors.affiliation: Genetics Unit, IRCCS S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy
authors.forename: Silvia
authors.initials: S
authors.lastname: Begni
authors.forename: Stefania
authors.initials: S
authors.lastname: Moraschi
authors.forename: Stefano
authors.initials: S
authors.lastname: Bignotti
authors.forename: Fabio
authors.initials: F
authors.lastname: Fumagalli
authors.forename: Luciana
authors.initials: L
authors.lastname: Rillosi
authors.forename: Jorge
authors.initials: J
authors.lastname: Perez
authors.forename: Massimo
authors.initials: M
authors.lastname: Gennarelli
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016194:Receptors, N-Methyl-D-Aspartate; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C485668:GRIN1 protein, human; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate