title: Cytologic diagnosis of low-grade papillary urothelial neoplasms (low malignant potential and low-grade carcinoma) in the context of the 1998 WHO/ISUP classification.
abstract: The 1998 World Health Organization/International Society of Urological Pathology (WHO/ISUP) classification of urothelial neoplasms introduced a category called papillary neoplasm of low malignant potential (LMP) and separated it from low-grade papillary urothelial carcinoma (LGPUC), which was thought to yield abnormal cells in cytology specimens. The objective of our study was to evaluate the effectiveness of urine cytology in diagnosing these lesions. Eighty-six paired transurethral surgical biopsy and corresponding urine cytology specimens representing the spectrum of urothelial papillary lesions were examined. Consensus diagnosis on each biopsy was made, and the distribution was as follows: 16 benign urothelium, 27 LMP, 28 LGPUC, and 15 high-grade papillary urothelial carcinoma (HGPUC). This was followed by a blinded independent review of the urine cytology specimens by three observers. Each cytology case was marked as negative, atypical, suspicious, or positive for malignant cells by using previously published cytologic criteria. When the negative and atypical diagnoses were grouped together as "benign" and the suspicious and malignant diagnoses as "malignant," the detection rate of "malignancy" of the lesions was as follows: LMP, 37%; LGPUC, 25%; and HGPUC, 53%. The false positive rate was 6%, and the positive predictive value (PPV) was 94%. Detection rates of cells that were at least "atypical" were as follows: LMP, 74%; LGPUC, 79%; and HGPUC, 100%. While most of the LMP and LGPUC cases yielded cells that were at least "atypical," there was no significant difference in the distribution of cytologic diagnoses for LMP and LGPUC cases (P > 0.05). Urine cytology in the context of the 1998 WHO/ISUP classification appears to be useful as a screening tool but does not appear to discriminate LMP effectively from LGPUC.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine and UPMC-Presbyterian, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Whisnant
authors.forename: Sheldon I
authors.initials: SI
authors.lastname: Bastacky
authors.forename: N Paul
authors.initials: NP
authors.lastname: Ohori
mesh_terms: D002291:Carcinoma, Papillary / Q000145:classification / Q000175:diagnosis / Q000652:urine; D002295:Carcinoma, Transitional Cell / Q000145:classification / Q000175:diagnosis / Q000652:urine; D006801:Humans; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016482:Urinalysis; D001749:Urinary Bladder Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000652:urine*; D014556:Urine / Q000166:cytology*; D019459:Urothelium / Q000473:pathology; D014944:World Health Organization