[NO-inhibiting activity of radioprotectors].
The effect of radioprotectors of different structure on the syntheses of nitric oxide induced by endotoxin in mice was studied. Using ESR-spectroscopy and spin trap techniques, it was shown that compounds of different chemical structure, such as aminothiols, isothiuronium derivatives, thiazolines, indolylalkylamines and others, suppressed the nitric oxide production in a whole body. The analysis of the relevant literature has confirmed the phenomenon described by the authors: radioprotectors show NO-inhibiting activity.
Proskuriakov
S Ia
SIa
Medical Radiology Research Centre, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. noo@mrrc.obninsk.ru
Kucherenko
N G
NG
Semenenko
M N
MN
Trishkina
A I
AI
Trofimova
T P
TP
Shteĭn
L V
LV
Verkhovskiĭ
Iu G
IuG
Konopliannikov
A G
AG
Mandrugin
A A
AA
Fedoseev
V M
VM
Skvortsov
V G
VG
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004578:Electron Spin Resonance Spectroscopy; D004731:Endotoxins; D008099:Liver / Q000378:metabolism; D008297:Male; D008624:Mercaptoethylamines / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D063086:Organothiophosphates / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019097:Spin Trapping
D004731:Endotoxins; D008624:Mercaptoethylamines; D063086:Organothiophosphates; D011837:Radiation-Protective Agents; D009569:Nitric Oxide; D003545:Cysteine