Sodium molybdate improves the phagocytic function in alloxan-induced diabetic rats.
Diabetes mellitus is a disease, which virtually affects all the systems in the body including the immune system. Bacterial infections are important causes of increased morbidity and mortality in diabetic patients. In the present study, we assessed the effect of molybdate on immune responses of diabetic rats. The phagocytic potency and nitroblue tetrazolium dye reduction capacity were found to be considerably lowered whereas soluble immune complex formation enhanced significantly in diabetic rats when compared with control rats. From our findings, it is suggested that dietary intake of molybdate may have a vital role in enhancing immune functions during diabetic mellitus.
Panneerselvam
Saraswathi
S
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600025, India. panneerselvam@eth.net
Govindasamy
Swaminathan
S
D000496:Alloxan; D000818:Animals; D000936:Antigen-Antibody Complex / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology*; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats
D000936:Antigen-Antibody Complex; D009580:Nitroblue Tetrazolium; D000496:Alloxan; D008982:Molybdenum; C024687:sodium molybdate(VI)