Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue.
Colgan
Sean P
SP
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Boston, MA.
Taylor
Cormac T
CT
Narravula
Sailaja
S
Synnestvedt
Kristin
K
Blume
Elizabeth D
ED
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D001483:Base Sequence; D015687:Cell Hypoxia / Q000502:physiology*; D002460:Cell Line; D018920:Coculture Techniques; D051546:Cyclooxygenase 2; D017931:DNA Primers; D004730:Endothelium, Vascular / Q000201:enzymology*; D004790:Enzyme Induction; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics*; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000235:genetics*; D020545:Respiratory Mucosa / Q000502:physiology; D014471:Umbilical Veins; D019459:Urothelium / Q000502:physiology
D017931:DNA Primers; D007527:Isoenzymes; D008565:Membrane Proteins; D015121:6-Ketoprostaglandin F1 alpha; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases