First enantiodivergent Baeyer-Villiger oxidation by recombinant whole-cells expressing two monooxygenases from Brevibacterium.
Microbial Baeyer-Villiger oxidations of representative mesomeric ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium were investigated. The two enzymes displayed enantiodivergent biotransformations on an array of structurally diverse substrates, allowing access to some key lactone intermediates in natural compound synthesis.
Mihovilovic
Marko D
MD
Vienna University of Technology, Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163, Austria. mmihovil@pop.tuwien.ac.at
Rudroff
Florian
F
Müller
Bernhard
B
Stanetty
Peter
P
D001711:Biotransformation; D001951:Brevibacterium / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism; D007783:Lactones / Q000138:chemical synthesis* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
D007527:Isoenzymes; D007659:Ketones; D007783:Lactones; D011994:Recombinant Proteins; D006899:Mixed Function Oxygenases