[Drug effect comparison of Rhubarb extract by the technology free of heating and the extracts form crude Rhubarb and from prepared Rhubarb].
OBJECTIVE
To study the effects of rhubarb extract by the technology free of heating (RETFH) and the extracts from crude rhubarb and from prepared rhubarb on intestine movement and analgesia in mice, and to compare the effects each other.


METHODS
Intestine movement was studied by determining the distance in intestine after administrating the extracts from different technology with ink as indicator. Analgesia effect was studied by hot plate test and torsion test induced by acetic acid for the extracts from different technology.


RESULTS
Diarrhea effect of low dose (0.75 mg/g) RETFH was moderate, and equal to that of high dose (3.00 mg/g) extract from prepared rhubarb. Remarkable analgesia effect of low dose (0.50 mg/g) RETFH was equal to that of middle and high dose (2.00 mg/g, 4.00 mg/g) extracts from prepared rhubarb and high dose (4.00 mg/g) extract from crude rhubarb.


CONCLUSIONS
0.50 mg/g RETFH possessed obvious diarrhea and analgesia effects. To utilize the technology free of heating may decrease dosage of rhubarb and save medicinal resource.
Hu
Yingqing
Y
Medical College of Chinese People's Armed Police Forces, Tianjin, 300162.
Wang
Zhongjun
Z
Song
Yueying
Y
Deng
Changhu
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007422:Intestines / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects*; D010528:Peristalsis / Q000187:drug effects; D012250:Rheum / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal