Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
OBJECTIVE
Ebselen, an organoselenium compound is able to modulate the inflammatory response in rodents. In the present study, the anti-inflammatory and antinociceptive activity of diaryl diselenides and ebselen was studied.


METHODS
Adult male Wistar rats and albino mice were treated with diaryl diselenides and ebselen in different doses.


METHODS
Carrageenin-induced paw edema, tail-flick, formalin, acetic acid-induced abdominal writhing and capsaicin models of pain were carried out. Data were analyzed by ANOVA followed by Duncan's multiple range when appropriate.


RESULTS
In all models, the most promising profile was displayed by diphenyl diselenide, which produced anti-inflammatory and antinociceptive activity significantly higher than ebselen. Diphenyl diselenide also produced dose-dependent antinociception when assessed in acetic acid-induced abdominal constriction, tail-flick test or formalin and capsaicin-induced nociception.


CONCLUSIONS
The data presented here provide evidence that administration of diphenyl diselenide produced anti-inflammatory and antinociceptive activity.
Nogueira
C W
CW
Laboratório de Bioquímica Toxicológica, Departamento de Química, CCNE, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Quinhones
E B
EB
Jung
E A C
EA
Zeni
G
G
Rocha
J B T
JB
D000009:Abdominal Muscles / Q000187:drug effects; D019342:Acetic Acid / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology; D001555:Benzene Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000494:pharmacology; D054833:Isoindoles; D008297:Male; D051379:Mice; D009119:Muscle Contraction; D009619:Nociceptors / Q000187:drug effects*; D016566:Organoselenium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D001555:Benzene Derivatives; D054833:Isoindoles; D016566:Organoselenium Compounds; C061132:diphenyldiselenide; D005557:Formaldehyde; C042986:ebselen; D019342:Acetic Acid; D002211:Capsaicin