title: Crystal nucleation in simple and complex fluids.
abstract: The application of density-functional methods from statistical mechanics to the nucleation of crystals from the melt is described. Simple fluids such as metals, with sizes comparable with the range of their attractive forces, are compared with complex fluids such as colloidal suspensions and proteins dissolved in solution. A different mechanism for crystal nucleation is proposed in the latter case, in which density (concentration) changes before periodic crystalline order appears. This leads to a theoretical foundation for empirical observations on the 'crystallization window' in protein crystallization. Comparisons are made with the results of computer simulation via molecular dynamics.
authors.affiliation: The James Franck Institute, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Oxtoby
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003460:Crystallization; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011506:Proteins