[The effects of n-butanol fraction of Lysimachia hemsleyana on the activities of lymphocytes in mice].
OBJECTIVE
To study the effects of n-butanol fraction from the whole plants (Lysimachia hemsleyana) on the phagocytic activities of the peritoneal macrophage, production of interleukin-2.


METHODS
We extracted the components with ethanol, acetic ether, n-butanol and chloroform, then studied the n-butanol fraction on the phagocytic activities of the peritoneal macrophage, production of interleukin-2 (IL-2) from splenocytes induced by ConA in mice in vitro.


RESULTS
n-Butanol fraction of an ethanol extract of air-dried herbs bilaterally regulated the IL-2 production from splenocytes induced by ConA, and enhanced the phagocytic activities of activated mouse peritoneal macrophages.


CONCLUSIONS
The results suggest that Lysimachia hemsleyana may has an immunoregulation effect and may be an potential agent in the treatment of the inflammatory pathological process and some autoimmune diseases.
Zhang
Lanling
L
Department of Rheumatology, Changhai Hospital, Second Military Medical University, Shanghai, 200433.
Meng
Jiming
J
Chen
Haisheng
H
Han
Xinghai
X
D020001:1-Butanol / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007376:Interleukin-2 / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects*; D029623:Primulaceae / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D020001:1-Butanol