title: Three new quassinoids, ailantinol E, F, and G, from Ailanthus altissima.
abstract: Three new quassinoids, ailantinol E (1), ailantinol F (2), and ailantinol G (3), and related compounds were isolated from Ailanthus altissima grown in Taiwan. Their structures were elucidated from spectral evidence. Each new quassinoid was evaluated for its antitumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The new quassinoids were found to show potent activity without showing any cytotoxicity. The screening for inhibitors against nitric oxide donor action was also conducted using the new quassinoids and some standard samples.
authors.affiliation: Faculty of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan.
authors.forename: Sadaaki
authors.initials: S
authors.lastname: Tamura
authors.forename: Narihiko
authors.initials: N
authors.lastname: Fukamiya
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Okano
authors.forename: Junko
authors.initials: J
authors.lastname: Koyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Wataru
authors.initials: W
authors.lastname: Aoi
authors.forename: Junko
authors.initials: J
authors.lastname: Takayasu
authors.forename: Masashi
authors.initials: M
authors.lastname: Kuchide
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
mesh_terms: D032268:Ailanthus; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018547:Plant Stems; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D036702:Quassins; C478581:ailantinol E; C478580:ailantinol F; C478579:ailantinol G