Regulation of chromosome condensation and segregation.
Regulated and controlled chromosome condensation and segregation is essential for the transmission of genetic information from one generation to the next. A myriad of techniques has been utilized over the last few decades to identify proteins required for the organized compaction of the massive length of a cell's DNA. A full understanding of the components and processes involved relies on further work, exploiting biochemical, genetic, cytological, and proteomics approaches to complete the picture of how a cell packages and partitions its genome during the cell cycle.
McHugh
Brian
B
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.
Heck
Margarete M S
MM
D000818:Animals; D020090:Chromosome Segregation / Q000502:physiology*; D002875:Chromosomes / Q000378:metabolism*; D006801:Humans