title: Antigen-specific histamine release in dogs with food hypersensitivity.
abstract: An in vitro evidence of IgE-mediated hypersensitivity to food allergens was detected by positive results of antigen-specific histamine release in dogs with food hypersensitivity. Eight dogs were diagnosed to have food hypersensitivity based on identification of offending food allergens with food elimination followed by oral food provocation. The percentages of histamine release against the stimulation of offending food allergens in the cases ranged from 2.1% to 70.9%. Six of the 8 cases showed histamine release higher than those of healthy control dogs. Four dogs showed relatively high histamine release at the percentage beyond 10% that was compatible with a positive value of histamine release in humans with food hypersensitivity. These findings would suggest that IgE-mediated hypersensitivity against food allergens could be involved in canine food hypersensitivity.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Rinei
authors.initials: R
authors.lastname: Ishida
authors.forename: Kenichi
authors.initials: K
authors.lastname: Masuda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Kurata
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006636:Histamine Release; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male
chemical_list: D000941:Antigens; D007073:Immunoglobulin E