LPO and ethanol biotransformation systems in the liver as markers of predisposition to ethanol hepatotoxicity.
An original experimental model for detecting organ-specific markers of predisposition to ethanol hepatotoxicity is proposed. A relationship between congenital activity of LPO processes in rat liver (before ethanol intoxication) and the type and severity of ethanol-induced damage to the liver was demonstrated using methods of mathematical modeling. It was proven that intact rats with genetically high MDA levels in the liver and more active systems of MDA generation in ascorbate- and NADPH-dependent reactions are prone to ethanol-induced damage to the liver.
Bushma
M I
MI
Medical University, Ministry of Health of Belarus' Republic, Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, Belarus.
Ambrushkevich
Yu G
YG
Zimatkin
S M
SM
Bushma
K M
KM
Omel'yanchik
S N
SN
Slyshenkov
V S
VS
Mel'nichenko
N G
NG
Kuz'mich
A B
AB
El'chaninova
M A
MA
D000079:Acetaldehyde / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D015415:Biomarkers; D001711:Biotransformation / Q000187:drug effects; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity*; D020022:Genetic Predisposition to Disease; D006519:Hepatitis, Alcoholic / Q000235:genetics*; D006520:Hepatitis, Animal / Q000235:genetics; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats
D015415:Biomarkers; D000431:Ethanol; D008315:Malondialdehyde; D009249:NADP; D000410:Alanine Transaminase; D000079:Acetaldehyde; D001205:Ascorbic Acid