title: Gender-related early immune changes in mice exposed to airborne suspended matter.
abstract: Immunotoxicity of the airborne suspended matter (ASM) from Upper Silesia (Poland) was investigated. The effect of the mixture of toxic components from the air suspended matter on the distribution and expression of several surface markers on lymphoid cells from thymus, spleen and axillary lymph nodes of female and male mice were examined. Corticosterone, a stress related hormone and sex hormones concentration in the plasma of animals were evaluated to discuss the interplay between the immune and endocrine system. The route, dose and length of application of ASM were examined. Thymus was shown to be a very sensitive organ to the effect of airborne suspended matter. Profound changes were shown in the distribution of CD4+ CD8+, CD4+ and CD8+ thymocytes subsets and TCRbeta and CD3 expression on thymic cells in young mice of both sexes exposed to ASM. Gender-related differences between female and male thymuses are rather quantitative than qualitative. Changes observed in the peripheral lymphoid organs were not so dramatic. The decrease of the percentage of CD19+ and Thy-1.2- in female spleens was noted. None changes in the plasma level of corticosterone and testosterone was observed in mice exposed to ASM, while a profound decrease of estradiol in female mice was noted. An interpretation all of these documented changes is attempted.
authors.affiliation: Institute of Zoology, Department of Immunology, Warsaw University, Warszawa, Poland. ndrela@biol.uw.edu.pl
authors.forename: Nadzieja
authors.initials: N
authors.lastname: Drela
authors.forename: Izabela
authors.initials: I
authors.lastname: Ześko
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis / Q000276:immunology*; D000704:Analysis of Variance; D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D000954:Antigens, Surface / Q000276:immunology*; D001365:Axilla / Q000503:physiopathology; D003345:Corticosterone / Q000097:blood; D004391:Dust / Q000032:analysis / Q000276:immunology*; D004958:Estradiol / Q000097:blood; D005260:Female; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology; D013739:Testosterone / Q000097:blood; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology*
chemical_list: D000393:Air Pollutants; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D004391:Dust; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013739:Testosterone; D004958:Estradiol; D003345:Corticosterone