title: A retrospective comparison between lamicel and gemeprost for cervical ripening before surgical interruption of first-trimester pregnancy.
abstract: To study the effect and complication rate of lamicel versus gemeprost as pretreatment to vacuum aspiration for the interruption of early pregnancy, the files of 622 medical records of women having a first-trimester abortion at Söder Hospital were studied retrospectively. Group A consisted of 317 women treated with lamicel in 1995 and Group B of 305 women treated with gemeprost in 1996. Complications were more common in Group A than in Group B (55 vs. 22; p < 0.05). Re-admission took place more often in Group A (25) than in Group B (6) (p < 0.05). The complications were more severe in Group A than in Group B. Using multivariate logistic regression analysis, the only impact factor for having a complication was the use of product for cervical priming. Gemeprost for preoperative treatment was found to render a fairly low rate of complications in this study, while complication rate was higher after treatment with lamicel.
authors.affiliation: Karolinska Institutet, Department of Obstetrics and Gynaecology at Stockholm Söder Hospital, S-118 83, Stockholm, Sweden. anna.lindelius@chello.se
authors.forename: Anna
authors.initials: A
authors.lastname: Lindelius
authors.forename: Ingela Hulthén
authors.initials: IH
authors.lastname: Varli
authors.forename: Margareta
authors.initials: M
authors.lastname: Hammarström
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D020070:Cervical Ripening / Q000187:drug effects*; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D011142:Polyvinyl Alcohol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011292:Premedication; D012086:Reoperation; D012189:Retrospective Studies; D013548:Sweden; D014595:Uterine Perforation / Q000209:etiology
chemical_list: C034860:Lamicel; C021182:gemeprost; D008278:Magnesium Sulfate; D011142:Polyvinyl Alcohol; D000527:Alprostadil