[Regulation of intracellular processes by fatty acids and end products of lipid peroxidation].
Products of ingested fat metabolism and also products of lipid peroxidation influenced on genes expression being natural ligands for nuclear receptors functioning as a transcription factors. This situation creates possibilities of diet modification by type and amount of fat as an important element of cancer prevention and cancer therapy. Functioning and activity of PPARs indicating the way of controlling their activity by another ligands than that included in the diet. This is a base for pharmacologic synthesis of a new class of specific drugs as an agonists for nuclear receptors of precisely defined histologic type of cancer.
Przybyszewski
Waldemar M
WM
Centrum Onkologii, Instytut im. M. Skłodowskiej-Curie, Oddział Gliwice.
Walichiewicz
Piotr
P
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D009369:Neoplasms / Q000178:diet therapy / Q000517:prevention & control*; D011506:Proteins / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism
D004041:Dietary Fats; D005227:Fatty Acids; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C459904:lipid peroxide-modified protein, human