Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.
Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells.
Winum
Jean Yves
JY
Laboratoire de chimie biomoléculaire, UMR 5032, Université Montpellier II-CNRS-laboratoires Mayoly Spindler, ENSCM, 8, rue de l'Ecole Normale, 34296 cedex, Montpellier, France. winumj@univ-montp2.fr
Bouissière
Jean Luc
JL
Passagne
Isabelle
I
Evrard
Alexandre
A
Montero
Véronique
V
Cuq
Pierre
P
Montero
Jean Louis
JL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D003114:Colony-Forming Units Assay; D004396:Coloring Agents; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D009499:Neutral Red; D009607:Nitrosourea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D009499:Neutral Red; D019853:O(6)-Methylguanine-DNA Methyltransferase; C054368:fotemustine