Selecting selective suppressors of selective uptake.
Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that mediates the selective uptake of HDL cholesteryl ester (CE) and the bidirectional flux of free cholesterol (FC). The identification of selective uptake inhibitors holds promise for mechanistic studies of SR-BI and for discovery of pharmaceuticals useful in therapy of atherosclerosis.
Williams
David L
DL
Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, NY 11794, USA.
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000378:metabolism; D001692:Biological Transport; D018955:CD36 Antigens; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018110:Receptors, Lipoprotein / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051116:Receptors, Scavenger
D018955:CD36 Antigens; D002788:Cholesterol Esters; D008076:Cholesterol, HDL; C059714:HDL cholesteryl ester; D008075:Lipoproteins, HDL; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C031616:high density lipoprotein receptors; D002784:Cholesterol