title: Cholinesterase inhibitory constituents from Onosma hispida.
abstract: Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2'-dihydroxy-7,4',5'-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2'-dihydroxy-7,5'-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.
authors.affiliation: International Centre of Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan.
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000818:Animals; D028082:Boraginaceae; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006736:Horses; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D002091:Butyrylcholinesterase