[Effect of N-oxidized pyridine derivatives on lipid peroxidation in the livers of rats].
Effects of N-oxide 2,6-dimetilpyridine (ivin) on the intensity of lipid peroxidation (in vivo and in vitro), microsomal hydroxylation and secretion of the bile (in vivo) were investigated. It has been shown that the preparation did not act significantly on the rate of lipid peroxidation in the liver homogenates both in vivo (5 mg/100 g, 4 weeks) and in vitro (10(-6)-10(-2) mol, incubation). Ivin did not change the activity of the microsomal hydroxylation (hexenal), but stimulated the excretion of biliary organic and inorganic components. The role of NO as a transmitter for effects of N-oxide 2,6-dimetilpyridine and the possibility of its influence on the processes under exploration via the modification of the structure of a biomembrane have being discussed to be one of the basic mechanisms.
Seredenko
M M
MM
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Rybal'chenko
V K
VK
Hovorukha
T M
TM
Nazarenko
A I
AI
Fil'
H B
HB
Baban
V M
VM
D000818:Animals; D001646:Bile / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D008054:Lipid Peroxides; D011725:Pyridines; D007501:Iron