title: Discovering risperidone: the LSD model of psychopathology.
abstract: In the 1970s and 1980s, Janssen Pharmaceutica Research, which had a broad interest in central nervous system disorders and nurtured intellectual freedom, developed original, and at times heretical, concepts. It took decades for the scientific community to endorse some of these concepts. Among them were such notions as an elementary particle of behaviour, the introduction of response quality in receptor theory, and the idea that tolerance does not develop to opioids. These concepts enabled the discovery of the antipsychotic risperidone, a unique full antagonist of the interoceptive effects of LSD.
authors.affiliation: Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres Cédex, France. francis.colpaert@pierre-fabre.com
authors.forename: Francis C
authors.initials: FC
authors.lastname: Colpaert
mesh_terms: D014150:Antipsychotic Agents / Q000266:history*; D006213:Hallucinogens / Q000266:history*; D049673:History, 20th Century; D008238:Lysergic Acid Diethylamide / Q000266:history*; D011599:Psychopathology / Q000266:history*; D018967:Risperidone / Q000266:history*
chemical_list: D014150:Antipsychotic Agents; D006213:Hallucinogens; D008238:Lysergic Acid Diethylamide; D018967:Risperidone