A simple determination method of the absolute configuration of 1-arylethanthiols by an intramolecular CH/pi shielding effect in 1H-NMR of diastereomeric thiol esters.
A simple method for the determination of the absolute configuration of 1-arylethanthiols was achieved by the observation of an intramolecular CH/pi shielding effect in (1)H-NMR of the corresponding thiol esters. (S)-Isomer of the diastereomers always shows remarkable shielding effect.
Matsugi
Masato
M
Department of Materials Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Japan.
Hagimoto
Yuri
Y
Itoh
Kinuyo
K
Nojima
Masatomo
M
Kita
Yasuyuki
Y
D004952:Esters; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011522:Protons; D013237:Stereoisomerism; D013439:Sulfhydryl Reagents / Q000737:chemistry*
D004952:Esters; D011522:Protons; D013439:Sulfhydryl Reagents