title: Non-invasive assessment of coronary flow velocity reserve: a new method using transthoracic Doppler echocardiography.
abstract: Transthoracic Doppler echocardiography (TTDE) allows noninvasive flow measurement in the distal left anterior descending artery (LAD). The feasibility of detecting coronary flow by contrast-enhanced TTDE with second harmonic technique was assessed, the coronary flow velocity reserve (CFVR) was evaluated in comparison to intracoronary Doppler flow (ICD) analysis and the CFVR after PTCA in LAD was investigated. In 77 (96%) of 80 patients, CFVR was successfully determined with intravenous adenosine infusion. Doppler signal quality was evaluated in the first 46 patients by use of intravenous Levovist infusion and second harmonic technique. The Doppler flow was not visible in 1. patient only. CFVR determined from TTDE (2.77 +/- 0.65) was correlated closely with those from ICD (2.88 +/- 0.78) measurements (y = 0.73x + 0.67, r = 0.87, P < 0.001). In conclusion, TTDE is a feasible method and provides reliable data on CFVR which can be used for follow-up after PTCA.
authors.affiliation: Institute of Cardiovascular Disease, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
authors.forename: Thomas
authors.initials: T
authors.lastname: Bartel
authors.forename: Holger
authors.initials: H
authors.lastname: Eggebrecht
authors.forename: Loredana
authors.initials: L
authors.lastname: Latina
authors.forename: Clemems
authors.initials: C
authors.lastname: von Birgelen
authors.forename: Guido
authors.initials: G
authors.lastname: Caspari
authors.forename: Xinfang
authors.initials: X
authors.lastname: Wang
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D003287:Contrast Media; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D011237:Predictive Value of Tests; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; D014665:Vasodilator Agents; C059891:SHU 508; D000241:Adenosine