A study of the photo-degradation kinetics of nifedipine by multivariate curve resolution analysis.
A multivariate curve resolution method based on the combination of Kubista approach and iterative target transformation method of Gemperline has been proposed. This method is a soft model and need no information about the spectrum of the product and mechanism of the reaction. The method was used to study the degradation kinetics of nifedipin, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxilic acid dimethyl ester, upon exposure to the light of a 40 W tungsten lamp. The spectra of the nifedipine, collected at different lighting times, were subjected to the factor analysis and two chemical components were detected in the reaction system. Pure spectra of the components involved and their concentration profiles were obtained. The results revealed that the photodecomposition kinetics of nifedipine is zero-order at the beginning of the reaction. However, when the reaction preceded more than 50%, the kinetics of reaction changed to a first-order manner. The rate constants for the zero-order and first order regions were estimated as regions (4.96+/-0.13) x 10(-9) M(-1) s(-1) and (6.22+/-0.10) x 10(-5) s(-1), respectively.
Shamsipur
Mojtaba
M
Department of Chemistry, Razi University, Kermanshah, Iran. mshamsipur@yahoo.com
Hemmateenejad
Bahram
B
Akhond
Morteza
M
Javidnia
Katayoun
K
Miri
Ramin
R
D002121:Calcium Channel Blockers / Q000032:analysis* / Q000528:radiation effects; D004355:Drug Stability; D007700:Kinetics; D008027:Light; D015999:Multivariate Analysis; D009543:Nifedipine / Q000032:analysis* / Q000528:radiation effects; D010084:Oxidation-Reduction; D010777:Photochemistry; D012996:Solutions
D002121:Calcium Channel Blockers; D012996:Solutions; D009543:Nifedipine