Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus.
Demyelination following infection of mice with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV) is immune-mediated. It has been demonstrated that MHV-specific CD4 and CD8 T cells are capable of causing demyelination independent of the other T cell subset. Recent work has also demonstrated that activated bystander CD8 T cells mediate significant demyelination. The ability of bystander CD4 T cells to mediate demyelination was investigated using CD4 T cell transgenic mice. The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to cause demyelination.
Haring
Jodie S
JS
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Perlman
Stanley
S
D000818:Animals; D024201:Bystander Effect / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017934:Coronavirus / Q000276:immunology*; D018352:Coronavirus Infections / Q000235:genetics / Q000276:immunology*; D003711:Demyelinating Diseases / Q000235:genetics / Q000276:immunology*; D016654:Genes, RAG-1 / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic