title: Molecular and clinical consequences of in vivo silicones biodegradation.
abstract: The object of the publication is the presentation of data referring to in vivo silicones biodegradation and their potential clinical and molecular consequences. Summing up, one needs to state that the products of silicones biodegradation are not biologically indifferent. In particular, different types of silanols are inhibitors of proteolytic enzymes and regulators of many metabolic processes as well as affect the cell growth and division, which distinctly indicates the potentially strong pharmacological action. The main objective of the molecular consequences of the biodegradation of siloxanes was the verification what impact siloxanes of various molecular weights and of various chain lengths exert on the conformational stability of biological molecules.
authors.affiliation: Department of Physical Chemistry, Instrumental Analysis Laboratory, Medical University of Gdańsk.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Łukasiak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Prokopowicz
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Jamrógiewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Honory
authors.forename: Janusz
authors.initials: J
authors.lastname: Jaśkiewicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Dorosz
authors.forename: Dorota
authors.initials: D
authors.lastname: Jachowska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Falkiewicz
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001673:Biodegradation, Environmental; D018427:Breast Implants; D006801:Humans; D008422:Materials Testing; D008968:Molecular Conformation; D008970:Molecular Weight; D051381:Rats; D012828:Silicones / Q000737:chemistry*
chemical_list: D012828:Silicones