[Signal function of the reactive oxygen species in regulatory networks of the cell reaction to damaging effects: contribution of radiosensitivity and genome instability].
Reactive oxygen species (ROS) have a few possible effects, such as metabolic (participation in regulation of protein functions), damaging (oxidative damage to proteins, lipids and nucleic acids) and signal; the latter is reviewed in the article. Superoxide anion-radical (O2-.), hydroperoxide (HO2) and nitroxide (NO) are capable to act as signal substances in the cell regulatory network, which determines a mode of cell response to disturbance: proliferation pace, a course of differentiation or a start of the apoptosis program. A role of ROS in the reaction network is reviewed: importance of their content in a cell; ROS-bound signal pathways, which trigger the programs of cell reactions to stimuli; initiations of the regulatory network, which determine a content of ROS in a cell; ROS reactions with network components, which influence its functioning. A significance of the ROS-bound segment of the network, which realizes regulatory signals of the damage, in formation of radiobiological effect is estimated. The data obtained by the authors are submitted; the prospects of studing substances (such as phenozan etc.), which can actively influence redox processes, as means of modification of radiation-induced genome instability and prevention of oncogenic transformation are considered.
Mikhaĭlov
V F
VF
State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia. ibphgen@rcibph.dol.ru
Mazurik
V K
VK
Burlakova
E B
EB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002477:Cells / Q000528:radiation effects*; D004249:DNA Damage; D053938:DNA Fragmentation; D004260:DNA Repair; D003851:Deoxyribonucleases / Q000378:metabolism; D004285:Dogs; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006706:Homeostasis; D006861:Hydrogen Peroxide; D015227:Lipid Peroxidation; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D009569:Nitric Oxide; D010084:Oxidation-Reduction; D010666:Phenylpropionates / Q000494:pharmacology; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011853:Radiobiology; D017382:Reactive Oxygen Species / Q000528:radiation effects*; D015398:Signal Transduction; D013481:Superoxides; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000975:Antioxidants; D010666:Phenylpropionates; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D013481:Superoxides; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D003851:Deoxyribonucleases; C047854:fenozan