title: Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study.
abstract: We investigated the incidence and the number of microbleeds (MBs) on T2*-weighted gradient-echo magnetic resonance imaging in 30 Binswanger's disease (BD) patients with diffuse white matter lesions and a varying degree of lacunar infarction, 51 multiple lacunar stroke (MLS) patients with multiple lacunar infarction and no or mild white matter lesions, and 59 elderly controls. MBs were found in 23 (77%) patients with BD, 26 (51%) patients with MLS, and 5 (8%) controls, and the incidence and the number of MBs were significantly greater in the BD group compared with MLS and control groups. Patients with BD had a more widespread location of MBs. More specifically, MBs were commonly found in areas within or surrounded by white matter lesions of the patients with BD. When 81 patients from both the BD and MLS groups were analyzed, logistic regression analysis showed that number of lacunar infarct, severity of white matter hyperintensity, and use of antiplatelet agents were significantly associated with MBs. Patients with BD exhibited a high frequency and number of MBs, indicating advanced bleeding-prone microangiopathy within the brain, which should be taken into account in treatment and management.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160-0023, Japan. hanyu@mb.kcom.ne.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shimizu
authors.forename: Masaru
authors.initials: M
authors.lastname: Takasaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Fujita
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kaneko
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Harada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology*; D020520:Brain Infarction / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology*; D016009:Chi-Square Distribution; D015140:Dementia, Vascular / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008833:Microcirculation / Q000473:pathology