Transplantation of embryonic hepatocytes. Experimental substantiation of a new approach to the therapy of liver failure.
The use of embryonic cells for the therapy of insufficiency in vitally important organs is a promising approach of transplantation medicine. Transplantation of fetal cells can restore liver functions during severe failure of various geneses. We review modern notions about histogenesis, structure, and mechanisms of functioning of low differentiated hepatocytes and extrahepatic cells that can be used for transplantation. Methods for ex vivo isolation of fetal cells for transplantation are described.
Sukhikh
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GT
Laboratory of Clinical Immunology, Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Institute of Biological Medicine, Moscow, Russia. immunolab@pregnancy.ru
Shtil'
A A
AA
D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D016332:Fetal Tissue Transplantation / Q000379:methods*; D022781:Hepatocytes / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000196:embryology*; D017114:Liver Failure, Acute / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods