title: Oral mucosal dysplastic lesions and early squamous cell carcinomas: underdiagnosis from incisional biopsy.
abstract: OBJECTIVE
  To evaluate the degree and causes of underdiagnosis of incisional biopsy in oral potentially malignant lesions (PML).
  
  
  METHODS
  Cross-sectional retrospective study.
  
  
  METHODS
  All pathology slides (incisional biopsy and resection specimen) from 46 patients with oral PML were reviewed and scored blind. The provisional diagnosis was considered in order to provide underdiagnosis or overdiagnosis according to whether this score was lower or higher than the final diagnosis.
  
  
  METHODS
  Concordance between the scores for provisional and final diagnoses was compared for reviewed and unreviewed assessments.
  
  
  RESULTS
  Upon review, underdiagnosis significantly decreased from 23.9% to 4.4% (P=0.016, chi-square with the Yates' correction). As the underdiagnosis ratio was not significantly influenced by intra- or inter-observer variability, it is likely to be related to pathologists' interpretation difficulties when examining incisional biopsy specimens.
  
  
  CONCLUSIONS
  The good quality of incisional biopsy samples was demonstrated, but clinicians should be conscious of the possible underdiagnosis by incisional biopsy when planning therapy in suspected early oral squamous cell carcinoma lesions.
authors.affiliation: Department of Biomedical Sciences, Oral Medicine Section, University of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pentenero
authors.forename: M
authors.initials: M
authors.lastname: Carrozzo
authors.forename: M
authors.initials: M
authors.lastname: Pagano
authors.forename: D
authors.initials: D
authors.lastname: Galliano
authors.forename: R
authors.initials: R
authors.lastname: Broccoletti
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: S
authors.initials: S
authors.lastname: Gandolfo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology*; D012189:Retrospective Studies