title: Dengue vaccines: preparing to roll back dengue.
abstract: Dengue is an emerging viral pathogen of growing global importance, infecting up to 100 million people annually. Although there have been many efforts over the last six decades to produce a vaccine to combat this infection, few have been able to meet the challenges posed by the unusual interplay between this virus and its human host. However, recent progress in molecular-based vaccine strategies, as well as a renewed commitment by the World Health Organisation to co-ordinate global efforts on vaccine development, finally provides hope that control of this serious disease may be at hand.
authors.affiliation: Centre for Hepatology, Department of Medicine, Royal Free & University College Medical School, Rowland Hill Street, London, NW3 2PF, UK. michael.jacobs@rfc.ucl.ac.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Jacobs
authors.forename: Paul
authors.initials: P
authors.lastname: Young
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology / Q000502:physiology; D003715:Dengue / Q000276:immunology* / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D012703:Serotyping; D014613:Vaccines, Attenuated / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014765:Viral Vaccines