Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain.
Melanoma inoculation induced marked mechanical allodynia and hyperalgesia in the periphery of the melanoma mass in mice from about day 10 post-inoculation. In the middle of the tumor, there were slight hyperalgesia and response disappearance in the early and late phases, respectively. PGP9.5-like immunoreactivities increased in the epidermis of the periphery of the tumor and disappeared from the dermis of the middle on day 18 post-inoculation, without apparent alterations on day 10. When using this pain model, one should consider the tumor site-dependent responses.
Zhang
Hong-Wei
HW
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama, Japan.
Iida
Yuko
Y
Andoh
Tsugunobu
T
Nojima
Hiroshi
H
Murata
Jun
J
Saiki
Ikuo
I
Kuraishi
Yasushi
Y
D000818:Animals; D006930:Hyperalgesia / Q000503:physiopathology*; D008545:Melanoma / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009412:Nerve Fibers / Q000502:physiology*; D010812:Physical Stimulation; D012867:Skin / Q000294:innervation*; D012878:Skin Neoplasms / Q000503:physiopathology*; D013869:Thiolester Hydrolases / Q000096:biosynthesis / Q000235:genetics; D043222:Ubiquitin Thiolesterase
D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase