title: [INF-gamma and GM-CSF concentrations in serum of patients with Lyme disease].
abstract: Lyme borreliosis is a disease caused by Borrelia burgdorferi spirochete. The purpose of this study was to INF-gamma and GM-CSF concentrations in patients with Lyme borreliosis before and after treatment. The analyzed group consisted of 60 patients diagnosed with tick Spirochetosis. INF-gamma and GM-CSF concentration before treatment was increased when compared with controls. After treatment it was the same as the value of controls. The increase in IFN-gamma and GM-CSF concentration in serum of patients with Lyme disease may be due to T lymphocyte activation caused by Borrelia burgdorferi spirochete.
authors.affiliation: Zakład Immunologii AM, Białymstoku. anetaiz@mp.pl
authors.forename: Aneta
authors.initials: A
authors.lastname: Izycka
authors.forename: Ewa
authors.initials: E
authors.lastname: Jabłońska
authors.forename: Joanna
authors.initials: J
authors.lastname: Zajkowska
authors.forename: Teresa
authors.initials: T
authors.lastname: Hermanowska-Szpakowicz
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D025065:Borrelia burgdorferi / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008193:Lyme Disease / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000907:Antibodies, Bacterial; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor