title: Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber.
abstract: We have developed an ultrahigh-resolution optical coherence tomographic system in which broadband continuum generation from a photonic crystal fiber is used to produce high longitudinal resolution. Longitudinal resolution of 1.3-microm has been achieved in a biological tissue by use of continuum light from 800 to 1400 nm. The system employed a dynamic-focusing tracking method to maintain high lateral resolution over a large imaging depth. Subcellular imaging is demonstrated.
authors.affiliation: Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Wang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Zhao
authors.forename: J S
authors.initials: JS
authors.lastname: Nelson
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.forename: Robert S
authors.initials: RS
authors.lastname: Windeler
mesh_terms: D000818:Animals; D004867:Equipment Design; D005240:Feasibility Studies; D007814:Larva / Q000166:cytology; D008962:Models, Theoretical; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*; D014981:Xenopus / Q000254:growth & development