title: Antiplatelet activities of aporphine alkaloids isolated from leaves of Magnolia obovata.
abstract: Five aporphine alkaloids, N-acetylanonaine ( 1), N-acetylxylopine ( 2), N-formylanonaine ( 3), liriodenine ( 4), and lanuginosine ( 5) as the antiplatelet constituents, were isolated from the methanol extract of leaves of Magnolia obovata. This is the first reported occurrence of 2 and 3 from genus Magnolia and 5 was isolated from this plant for the first time. Compounds 1, 2 and 3 showed 60 approximately 264-fold stronger inhibitory effects than acetylsalicylic acid (ASA) to rat platelet aggregation induced by collagen, epinephrine, arachidonic acid (AA), or U46619.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Pyo
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Yun-Choi
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Hong
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000494:pharmacology*; D016718:Arachidonic Acid; D003094:Collagen; D004837:Epinephrine; D006801:Humans; D020128:Inhibitory Concentration 50; D031566:Magnolia; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000470:Alkaloids; D001060:Aporphines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C081279:aporphine; D016718:Arachidonic Acid; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D003094:Collagen; D004837:Epinephrine