title: Insulin and the blood-brain barrier.
abstract: Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.
authors.affiliation: Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA. steve.woods@psychiatry.uc.edu
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Woods
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
authors.forename: Denis G
authors.initials: DG
authors.lastname: Baskin
authors.forename: Michael W
authors.initials: MW
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology*
chemical_list: D007328:Insulin