Molecular mechanisms of the immunosuppressive effect of erythroid cells.
This review presents data suggesting a new immunoregulatory role of the erythroid nucleus-containing cells. The three main mechanisms of the possible immunosuppressive effect of these cells are described. It has been demonstrated that the erythroid nucleus-containing cells produce a variety of both pro- and anti-inflammatory cytokines. The p15 protein (a product of the env gene) is considered to provide a novel immunosuppressive mechanism. Finally, the existing data suggest that the erythroid nucleus-containing cells are able to produce an immunosuppressive factor, which is different from the known cytokines. It has been proposed that the immunosuppressive effect of the erythroid nucleus-containing cells greatly contributes to the regulation of the immune homeostasis in normal and immunopathological conditions.
Kozlov
Vladimir A
VA
Institute of Clinical Immunology, Siberian Branch of RAMS, Yandritsovskaya str. 14, Novosibirsk-99 630099, Russia. v_kozlov@online.nsk.su
D000276:Adjuvants, Immunologic / Q000502:physiology; D000818:Animals; D015672:Erythroid Precursor Cells / Q000276:immunology* / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice
D000276:Adjuvants, Immunologic