title: Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.
abstract: Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells.
authors.affiliation: Laboratoire de chimie biomoléculaire, UMR 5032, Université Montpellier II-CNRS-laboratoires Mayoly Spindler, ENSCM, 8, rue de l'Ecole Normale, 34296 cedex, Montpellier, France. winumj@univ-montp2.fr
authors.forename: Jean Yves
authors.initials: JY
authors.lastname: Winum
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Bouissière
authors.forename: Isabelle
authors.initials: I
authors.lastname: Passagne
authors.forename: Alexandre
authors.initials: A
authors.lastname: Evrard
authors.forename: Véronique
authors.initials: V
authors.lastname: Montero
authors.forename: Pierre
authors.initials: P
authors.lastname: Cuq
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Montero
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D003114:Colony-Forming Units Assay; D004396:Coloring Agents; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D009499:Neutral Red; D009607:Nitrosourea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D009499:Neutral Red; D019853:O(6)-Methylguanine-DNA Methyltransferase; C054368:fotemustine