Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry.
ESI mass spectra show that up to five ruthenium molecules can bind non-covalently to double stranded 16mer DNA, and provide information on the relative affinity and DNA sequence selectivity of different ruthenium complexes.
Beck
Jennifer L
JL
Department of Chemistry, University of Wollongong, Northfields Avenue, Wollongong 2522, Australia.
Gupta
Rajesh
R
Urathamakul
Thitima
T
Williamson
Nyree L
NL
Sheil
Margaret M
MM
Aldrich-Wright
Janice R
JR
Ralph
Stephen F
SF
D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism*; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D013379:Substrate Specificity
D007364:Intercalating Agents; D009841:Oligonucleotides; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA