Photoinduced DNA cleavage by benzenediradical equivalents. 1,3- and 1,4-bis(dicarbonylcyclopentadienyliron)benzene.
Upon photolysis, diiron complexes 1,4- and 1,3-Fp(2)C(6)H(4) (1 and 2) linearize plasmid DNA at ratios as low as 1.5 and 3.0 molecules/bp DNA, respectively. Additionally, single-strand cleavage was observed at ratios higher than 0.05 and 0.19 molecules/bp DNA for 1 and 2, respectively. Radical scavenging studies and metal radical control experiments implicate carbon-centered radicals as participants in the cleavage pathway.
Mohler
Debra L
DL
Department of Chemistry, Emory University, Atlanta, GA 30322, USA. dmohler@emory.edu
Gray Coonce
Janet
J
Predecki
Daniel
D
D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects*; D003720:Densitometry; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D016166:Free Radical Scavengers; D008027:Light; D010782:Photolysis; D010957:Plasmids / Q000737:chemistry
C478340:1,3-bis(dicarbonylcyclopentadienyliron)benzene; C478339:1,4-bis(dicarbonylcyclopentadienyliron)benzene; D003517:Cyclopentanes; D005296:Ferrous Compounds; D016166:Free Radical Scavengers; D004247:DNA