New insights into the roles of agrin.
The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse, the organization of the cytoskeleton and the amelioration of function in diseased muscle. So the activities of agrin might be of broader significance than previously anticipated.
Bezakova
Gabriela
G
Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Ruegg
Markus A
MA
D018171:Agrin / Q000235:genetics / Q000502:physiology*; D017398:Alternative Splicing; D000818:Animals; D014644:Genetic Variation; D006801:Humans; D009424:Nervous System Physiological Phenomena; D009469:Neuromuscular Junction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D014158:Transcription, Genetic
D018171:Agrin; D020033:Protein Isoforms