Prevention of red cell dehydration: a possible new treatment for sickle cell disease.
One of the pathogenetic mechanisms responsible for sickling of erythrocytes in patients with sickle cell disease is the decreased hydration status of the cells. In this brief review, we discuss the pathophysiologic background and explore some new treatment options to prevent vaso-occlusive crises or other problems in this patient population.
Mueller
B U
BU
Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. mueller_b@al.tch.harvard.edu
Brugnara
C
C
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D000818:Animals; D001834:Body Water; D002648:Child; D003022:Clotrimazole / Q000494:pharmacology / Q000627:therapeutic use; D003681:Dehydration; D004195:Disease Models, Animal; D004913:Erythrocytes, Abnormal / Q000737:chemistry* / Q000187:drug effects; D006451:Hemoglobin, Sickle / Q000737:chemistry; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008822:Mice, Transgenic; D018384:Oxidative Stress; D024681:Potassium Channels, Calcium-Activated / Q000097:blood / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000187:drug effects; D012995:Solubility; D027981:Symporters / Q000097:blood / Q000187:drug effects; D000096922:K Cl- Cotransporters
D003022:Clotrimazole; D006451:Hemoglobin, Sickle; D008274:Magnesium; D024681:Potassium Channels, Calcium-Activated; D000254:Sodium-Potassium-Exchanging ATPase; D027981:Symporters; D000096922:K Cl- Cotransporters