Isoform/variant mRNAs for sex steroid hormone receptors in humans.
The open reading frames of human sex steroid hormone receptors (hSSHRs) are composed of eight exons. In addition, the presence of various exons - including 5'-untranslated exons, alternative coding exons and novel 'intronic' exons - has been demonstrated in the genes encoding hSSHRs. The isoform/variant hSSHR mRNAs generated from thes e exons can be tentatively classified into seven types. In type 1, different mRNAs are generated with the use of alternative transcription start sites. In type 2, one or more exons are skipped. In type 3, one or more exons are duplicated. In type 4, distinct mRNAs containing different 5'-untranslated exon(s) are synthesized. In type 5, distinct mRNAs possessing different coding exon(s) are generated. In type 6, mRNA is synthesized by intronic exons and coding exons 4/5-8. In type 7, mRNA with insertion of intronic exon(s) is generated. Here, we review the isoform/variant hSSHR mRNAs and the structure of the genes encoding them.
Hirata
Shuji
S
Dept of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Nakakoma, Yamanashi, Japan. shirata@swallow.res.yamanashi-med.ac.jp
Shoda
Tomoko
T
Kato
Junzo
J
Hoshi
Kazuhiko
K
D017398:Alternative Splicing; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005091:Exons / Q000235:genetics*; D006801:Humans; D016366:Open Reading Frames / Q000235:genetics; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics* / Q000378:metabolism
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D020033:Protein Isoforms; D012333:RNA, Messenger; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone