title: Trypanocidal diarylheptanoids from Aframomum letestuianum.
abstract: Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC(50) values in the range of 1-3 microg/mL were found for compounds 3 and 5.
authors.affiliation: Department of Chemistry, University of Dschang, Box 67, Dschang, Cameroon.
authors.forename: Pierre
authors.initials: P
authors.lastname: Kamnaing
authors.forename: Apollinaire
authors.initials: A
authors.lastname: Tsopmo
authors.forename: Eric A
authors.initials: EA
authors.lastname: Tanifum
authors.forename: Marguerite H K
authors.initials: MH
authors.lastname: Tchuendem
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Johnson F
authors.initials: JF
authors.lastname: Ayafor
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Donna
authors.initials: D
authors.lastname: Rattendi
authors.forename: Maurice M
authors.initials: MM
authors.lastname: Iwu
authors.forename: Brian
authors.initials: B
authors.lastname: Schuster
authors.forename: Cyrus
authors.initials: C
authors.lastname: Bacchi
mesh_terms: D000818:Animals; D002163:Cameroon; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D036381:Diarylheptanoids; D014344:Trypanocidal Agents; C476660:letestuianin A; C476661:letestuianin B; C476662:letestuianin C