title: Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp.
abstract: Two new pimarane diterpenes, diaportheins A (1) and B (2), were isolated from a culture broth of the fungus Diaporthe sp. BCC 6140. Diaporthein B (2) strongly inhibited the growth of Mycobacterium tuberculosis with the MIC value of 3.1 microg/mL, while diaporthein A (1) showed only mild activity (MIC value of 200 microg/mL).
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Suppamit
authors.initials: S
authors.lastname: Dettrakul
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Sombat
authors.initials: S
authors.lastname: Nopichai
authors.forename: Chotika
authors.initials: C
authors.lastname: Suyarnsestakorn
authors.forename: Morakot
authors.initials: M
authors.lastname: Tanticharoen
authors.forename: Yodhathai
authors.initials: Y
authors.lastname: Thebtaranonth
mesh_terms: D000818:Animals; D000904:Antibiotics, Antitubercular / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000904:Antibiotics, Antitubercular; D004224:Diterpenes; C478320:diaporthein A; C478319:diaporthein B