[Comparative experimental study of antiemetic action of latranum in radiation-induced vomiting and vomiting caused by apomorphine].
The experiments on dogs showed that Latranum, a selective blocker of serotonin 5-HT3-receptors, has a moderate capacity to modify emetic reaction caused by dophamin-stimulating action of Apomorphinum. These results, taking in account of our preliminary experimental data obtained by a model of early radiation-induced emetic reactions, show that the high antiemetic effect of Latranum may affect another mechanisms of the initiation of early radiation-inducing vomiting which do not connect immediately with the chemoreceptor trigger zone.
Martirosov
K S
KS
State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia.
Grigor'ev
Iu G
IuG
Zorin
V V
VV
Borovkov
M V
MV
D000284:Administration, Oral; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001058:Apomorphine / Q000009:adverse effects*; D002588:Cesium Radioisotopes; D004285:Dogs; D018491:Dopamine Agonists / Q000009:adverse effects*; D005260:Female; D008297:Male; D017294:Ondansetron / Q000008:administration & dosage / Q000627:therapeutic use*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology
D000932:Antiemetics; D002588:Cesium Radioisotopes; D018491:Dopamine Agonists; D017294:Ondansetron; D001058:Apomorphine