Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis.
We evaluated the in vitro activity against Mycobacterium tuberculosis of the combination of fluoroquinolones and linezolid with classical drugs. The combination of isoniazid with fluoroquinolones had synergic activity in nine of the ten isoniazid-susceptible strains. We also found synergism between rifampicin and linezolid in five of the 15 strains susceptible to rifampicin. The clinical significance of these findings should be evaluated.
Rodriguez Díaz
Juan Carlos
JC
Sección de Microbiología, Hospital General Universitario de Elche, Universidad Miguel Hernández, Camí de L'Almazara, no 11, 03203 Elche-Alicante, Spain. micro_elx@gva.es
Ruiz
M
M
López
M
M
Royo
G
G
D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D066298:In Vitro Techniques; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology*; D014376:Tuberculosis / Q000382:microbiology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid