Tetraacyldiborates: selective and efficient acylation reagents suitable for multiple parallel synthetic applications.
Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable.
Gentry
Elmer J
EJ
Department of Medicinal Chemistry, Kansas University, Lawrence, KS 66045-2506, USA.
Telikepalli
Hanumaiah
H
Srinivas
Pusuluri
P
Mitscher
Lester A
LA
D000215:Acylation; D000438:Alcohols / Q000138:chemical synthesis; D000588:Amines / Q000138:chemical synthesis; D001881:Borates / Q000138:chemical synthesis*; D002614:Chelating Agents / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis
D000438:Alcohols; D000588:Amines; D001881:Borates; D002614:Chelating Agents; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds