title: Pulmonary carcinosarcoma in a cat.
abstract: A Domestic Shorthaired cat was presented with coughing and severe respiratory distress. Thoracic radiographs revealed a lobar mass and numerous additional cavitated intrapulmonary masses. The cat was euthanized and submitted for necropsy. Histological examination of the large mass revealed 2 distinct neoplastic components consisting of bronchial adenocarcinoma admixed with neoplastic areas composed of highly atypical undifferentiated spindle cells (sarcomatous component). Simultaneous expression of vimentin and cytokeratin by a subpopulation of neoplastic epithelial cells and by rare neoplastic spindle cells was identified. On the basis of histology and immunohistochemical results, a diagnosis of primary pulmonary carcinosarcoma with intrapulmonary epithelial metastases was made. Pulmonary carcinosarcoma is a well-known pathological entity in humans. It is a rare tumor in animals and has not been previously reported in cat.
authors.affiliation: Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Università degli Studi di Milano, via Celoria 10, 20133 Milano, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ghisleni
authors.forename: Valeria
authors.initials: V
authors.lastname: Grieco
authors.forename: Marcello
authors.initials: M
authors.lastname: Mazzotti
authors.forename: Mario
authors.initials: M
authors.lastname: Caniatti
authors.forename: Paola
authors.initials: P
authors.lastname: Roccabianca
authors.forename: Eugenio
authors.initials: E
authors.lastname: Scanziani
mesh_terms: D000818:Animals; D002296:Carcinosarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male