title: Porphyria cutanea tarda, C282Y, H63D and S65C HFE gene mutations and hepatitis C infection: a study from southern France.
abstract: BACKGROUND
  To evaluate the role of genetic factors in the pathogenesis of porphyria cutanea tarda (PCT) and their association with chronic hepatitis C.
  
  
  OBJECTIVE
  To investigate the relations between hemochromatosis gene (HFE) mutations and PCT in the south of France and their links with chronic hepatitis C virus (HCV) infection.
  
  
  METHODS
  The genotype for the C282Y, H63D and S65C mutations of HFE was determined in 33 patients with PCT, 46 patients with HCV infection but without PCT and 58 controls. Iron status and HCV, HBV and HIV serologies were studied in all patients.
  
  
  RESULTS
  A statistically significant increase in the C282Y mutation was found in PCT patients. No difference was found for H63D or S65C mutations. The prevalence of HCV infection was higher in PCT patients than controls.
  
  
  CONCLUSIONS
  C282Y mutations and HCV infection but not H63D or S65C mutations are PCT-triggering or associated factors in the south of France.
authors.affiliation: Department of Dermatology, Archet-2 Hospital, Nice, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Chiavérini
authors.forename: Gilles
authors.initials: G
authors.lastname: Halimi
authors.forename: Denis
authors.initials: D
authors.lastname: Ouzan
authors.forename: Philippe
authors.initials: P
authors.lastname: Halfon
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Ortonne
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lacour
mesh_terms: D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D000071020:Hemochromatosis Protein; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D017119:Porphyria Cutanea Tarda / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011446:Prospective Studies
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins