Cytotoxic bis-3,4-dihydro-beta-carbolines and bis-beta-carbolines.
Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.
Jiang
Wei-Qun
WQ
UMR 6013 Isolement, Structure, Transformations et Synthèse de Produits Naturels, IFR 53 Biomolécules, Faculté de Pharmacie, 51 rue Cognacq Jay, F-51096 Reims Cédex, France.
Charlet-Fagnère
Catherine
C
Sapi
Janos
J
Laronze
Jean-Yves
JY
Renard
Pierre
P
Pfeiffer
Bruno
B
Léonce
Stéphane
S
D000577:Amides / Q000737:chemistry; D000818:Animals; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000577:Amides; D002243:Carbolines