title: [Association study of heroin dependence and catechol-O-methyltransferase gene].
abstract: OBJECTIVE
  To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene.
  
  
  METHODS
  Genotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls.
  
  
  RESULTS
  No differences in genotype and allele frequencies of 108 val/met polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=1.67, P=0.43; allele-wise: chi-square=1.23, P=0.27). No differences in genotype and allele frequencies of 900 Ins C/Del C polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=3.73, P=0.16; allele-wise: chi-square=0.76, P=0.38).
  
  
  CONCLUSIONS
  The results suggested that neither 108 val/met polymorphism nor 900 Ins C/Del C polymorphism of COMT gene was associated with heroin dependence.
authors.affiliation: Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P.R. China. caoliping@hotmail.com
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Xiehe
authors.initials: X
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006556:Heroin Dependence / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
chemical_list: D004247:DNA; D002394:Catechol O-Methyltransferase