title: Granule cells of the dentate gyrus with basal and recurrent dendrites in schizophrenic patients and controls. A comparative Golgi study.
abstract: We report on structural variability of granule cells in the human dentate gyrus. Granule cells with basal and recurrent dendrites are a normal finding in the human brain. We detect 28.3% granule cells with basal dendrites in non-psychiatrically ill humans compared to rats (2%) and primates (10%). This can be seen as an indication for the higher phylogeny of the human brain. In addition we find a significantly higher incidence of granule cells with basal dendrites (45.7%) in brains of schizophrenic patients. Whereas drug influences during lifetime cannot fully be excluded, we tend to interpret this finding as a plastic reaction to prenatal developmental malformations of the impinging rostral entorhinal region.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Federal Republic of Germany. senitz@mail.uni-wuerzburg.de
authors.forename: D
authors.initials: D
authors.lastname: Senitz
authors.forename: H
authors.initials: H
authors.lastname: Beckmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D003712:Dendrites / Q000473:pathology*; D018891:Dentate Gyrus / Q000166:cytology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*; D016622:Silver Staining / Q000379:methods*