title: Non-functional adrenocortical adenoma with extensive degeneration.
abstract: We report a case of non-functional adrenocortical adenoma of 5.5 x 5.5 x 3.2 cm in size that had an unusual histopathological appearance in two respects. First, the tumor contained small adipose foci with osteogenesis and was suspected of being a myelolipoma based on its appearance on computerized tomography (CT) and magnetic resonance imaging. However, pathologically, the fat element was seen focally and was not accompanied by hematopoietic cells, and the diagnosis of myelolipoma was abandoned. Second, the tumor was suspected of being an adrenal carcinoma based on its appearance on CT scans and showed extensive degeneration: fibrosis, hemorrhage, loss of parenchyma and moderate atypism of the tumor cells. However, as the architecture of the tumor cells was non-diffuse and there were no necrotic foci or mitoses, and vascular or capsular invasion were not present, the tumor was concluded to be an adrenocortical adenoma rather than a carcinoma. We diagnosed the tumor as a non-functional adrenocortical adenoma with extensive degeneration as the extensive areas of fibrosis were particularly remarkable. Furthermore, the extensive areas of degeneration might have been caused not only by an ischemic effect but also by low hormone levels.
authors.affiliation: Division of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Masugi
authors.forename: Kaori
authors.initials: K
authors.lastname: Kameyama
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
authors.forename: Makio
authors.initials: M
authors.lastname: Mukai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hara
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohigashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Murai
mesh_terms: D000302:Adrenal Cortex / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018246:Adrenocortical Adenoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018209:Myelolipoma / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed