Decrement in area of muscle responses to repetitive nerve stimulation.
Measurement of the decremental muscle response to repetitive nerve stimulation (RNS) has low yields for the diagnosis of neuromuscular transmission defects compared with single fiber electromyography (SFEMG). We compared area and amplitude of muscle responses to RNS in 87 patients and 30 controls, using SFEMG as the reference standard. Decrement of response area provided additional diagnostic yields of 5.3% to 30% depending on the muscle examined and disease severity, and is recommended as a diagnostic adjunct to measurement of amplitude decrement during RNS.
Lo
Y L
YL
Department of Neurology, Singapore General Hospital, Outram Road, Singapore. gnrlyl@sgh.com.sg
Dan
Y F
YF
Leoh
T H
TH
Tan
Y E
YE
Ratnagopal
P
P
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009469:Neuromuscular Junction / Q000503:physiopathology*; D020511:Neuromuscular Junction Diseases / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology; D011446:Prospective Studies; D009435:Synaptic Transmission / Q000502:physiology