title: Neurotrophin-4 is required for tolerance to morphine in the mouse.
abstract: Tolerance is an important component of opiate addiction, but the molecular basis for this phenomenon remains obscure. Here, we report that mice lacking neurotrophin-4 (NT4) display substantially reduced tolerance to morphine compared to wild-type. However, there were no deficits in sensitization and withdrawal, other behaviors relevant to drug addiction. Since NT4 knockout mice also show abnormalities in long-term but not short-term memory, our findings suggest common molecular pathways for some of the enduring changes of drug addiction and memory consolidation.
authors.affiliation: Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: Desmond J
authors.initials: DJ
authors.lastname: Smith
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Leil
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D004361:Drug Tolerance / Q000502:physiology*; D007274:Injections, Intraperitoneal; D051379:Mice; D018345:Mice, Knockout; D009020:Morphine / Q000008:administration & dosage*; D009414:Nerve Growth Factors / Q000172:deficiency* / Q000235:genetics; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D013375:Substance Withdrawal Syndrome / Q000235:genetics / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D009020:Morphine; C073922:neurotrophin 4