A specific chromosome aberration in a keratoacanthoma.
Specific cytogenetic changes observed in various tumors indicate that a chromosomal event may play a key role in malignant transformation. We present a patient with keratoacanthoma with a sole chromosome abnormality. The karyotype found in short-term culture was 46,XY,t(2;8)(p13;p23); a normal male chromosome complement was also found. The finding of t(2;8) as a sole anomaly suggests that this aberration is a primary change in keratoacanthoma and might be important in the pathobiology of this tumor.
Kim
Dae-Kwang
DK
Department of Anatomy, Institute for Medical Genetics, Keimyung University School of Medicine, Dongsan-dong, Jung-gu, Daegu 700-712, South Korea. dkkim@dsmc.or.kr
Kim
Joo-Young
JY
Kim
Hyeung-Tae
HT
Han
Ki-Hwan
KH
Shon
Dae-Gu
DG
D000328:Adult; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D005385:Fingers / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D007636:Keratoacanthoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured