Late thrombosis: a problem solved?
Late thrombosis (angiographic total occlusion associated with an acute coronary syndrome) is a potentially life-threatening complication after intracoronary radiation therapy. This review is intended to explore the preclinical and clinical evidence for late thrombosis, to discuss the etiology, and to provide guidelines for future management. Although we have gained a greater understanding of this complex entity, further research is required in a quest to curtail late thrombosis rates.
Ajani
Andrew E
AE
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA.
Cheneau
Edouard
E
Leborgne
Laurent
L
Wolfram
Roswitha
R
Waksman
Ron
R
D000818:Animals; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology / Q000532:radiotherapy; D023903:Coronary Restenosis / Q000453:epidemiology / Q000517:prevention & control / Q000532:radiotherapy; D019317:Evidence-Based Medicine; D006801:Humans; D011340:Problem Solving; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors