title: Chain length is the main determinant of the folding rate for proteins with three-state folding kinetics.
abstract: We demonstrate that chain length is the main determinant of the folding rate for proteins with the three-state folding kinetics. The logarithm of their folding rate in water (k(f)) strongly anticorrelates with their chain length L (the correlation coefficient being -0.80). At the same time, the chain length has no correlation with the folding rate for two-state folding proteins (the correlation coefficient is -0.07). Another significant difference of these two groups of proteins is a strong anticorrelation between the folding rate and Baker's "relative contact order" for the two-state folders and the complete absence of such correlation for the three-state folders.
authors.affiliation: Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. ogalzit@vega.protres.ru
authors.forename: Oxana V
authors.initials: OV
authors.lastname: Galzitskaya
authors.forename: Sergiy O
authors.initials: SO
authors.lastname: Garbuzynskiy
authors.forename: Dmitry N
authors.initials: DN
authors.lastname: Ivankov
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Finkelstein
mesh_terms: D007700:Kinetics; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins