[Effect of inhibitors of cyclooxygenase and lypoxygenase pathway of metabolism of arachidonic acid on the development and suppression of the immune response in mice].
The influence of indomethacin (IM) and nordihydroguaiaretic acid (NDGA) as inhibitors of cyclooxygenase and lypoxygenase pathways of arachidonic acid metabolism, accordingly, on the development of the immune response (IR) to sheep red blood cells (SRBC), as well as on the formation and functional activity of the antigen-induced (by the tolerogenous dose of SRBC) T-suppressors (AITs) was studied. Investigation was carried out on mice of line CBA. The IR was estimated by quantity of antibody-forming cells in the mouse spleen. The functional activity of AITs was determined in the transfer adopting system by the intensity of IR suppression in mice--recipients. The data obtained have demonstrated, that both inhibitors mainly stimulated the IR which was more expressed at NDGA application and depended on a phase of the IR. The stimulation of the IR was related with a suppression of AITs and a decrease in their functional activity.
Martynova
T V
TV
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Aleksieieva
I M
IM
Bryzhina
T M
TM
Aleksiuk
L I
LI
Sukhina
V S
VS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D016718:Arachidonic Acid / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D009637:Masoprocol / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D013491:Suppressor Factors, Immunologic / Q000037:antagonists & inhibitors / Q000276:immunology*
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D013491:Suppressor Factors, Immunologic; D016718:Arachidonic Acid; D009637:Masoprocol; D007213:Indomethacin