A practical synthesis of a (1-->6)-linked beta-D-glucosamine nonasaccharide.
A (1-->6)-beta-D-glucosamine nonasaccharide was convergently synthesized using isopropyl thioglycosides as donors. Anomeric acetylated glucosamine derivatives were proved to be good acceptors in the NIS/TMSOTf catalyzed glycosylation. The target nonasaccharide showed a mild antitumor activity against H22 on the preliminary mice tests.
Yang
Feng
F
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Academia Sinica, P.O. Box 2871, 100085, Beijing, PR China.
Du
Yuguo
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002240:Carbohydrate Sequence; D005944:Glucosamine / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D006031:Glycosylation; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry
D000970:Antineoplastic Agents; D009844:Oligosaccharides; D005944:Glucosamine