title: Two-year follow-up study after human parvovirus B19 infection.
abstract: BACKGROUND
  Acute human parvovirus B19 (B19) infection induces systemic lupus erythematosus (SLE)-like symptoms. It has been controversial whether B19 infection causes SLE and rheumatoid arthritis (RA).
  
  
  OBJECTIVE
  This study prospectively investigated whether symptoms of B19 infection persisted for more than 2 years and whether persistent symptoms contributed to the development of SLE and RA.
  
  
  METHODS
  In this prospective study, clinical findings were examined and laboratory examinations were performed in 42 adult patients 1, 2, 6, 12 and 24 months after the first consultation.
  
  
  RESULTS
  Most acute symptoms disappeared within 2 weeks. However, arthralgia continued for 2 months in 2 women, 6 months in 1 woman and more than 2 years in 1 woman with positive antinuclear antibody and hypocomplementemia. The clinical findings of the patient with persistent arthralgia did not fulfill the criteria for SLE and RA.
  
  
  CONCLUSIONS
  The symptoms caused by B19 infection were transient in most cases but persisted in 1 case in our series.
authors.affiliation: Department of Dermatology, Ogaki Municipal Hospital, Ogaki, Japan. tosyo1@omh.ogaki.gifu.jp
authors.forename: Mariko
authors.initials: M
authors.lastname: Seishima
authors.forename: Zuiei
authors.initials: Z
authors.lastname: Oyama
authors.forename: Mahiro
authors.initials: M
authors.lastname: Yamamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D018771:Arthralgia / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000209:etiology; D015941:Complement Hemolytic Activity Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000276:immunology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000974:Antibodies, Antinuclear