Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia.
Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.
Albin
Roger L
RL
Geriatrics Research, Education Clinical Center, Ann Arbor VAMC and Department of Neurology, University of Michigan 41809-0585, USA. ralbin@umich.edu
Cross
Donna
D
Cornblath
Wayne T
WT
Wald
John A
JA
Wernette
Kristine
K
Frey
Kirk A
KA
Minoshima
Satoshi
S
D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism; D002799:Cholinergic Fibers / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D010880:Piperidines; D013764:Tetrahydronaphthalenes; D015899:Tomography, Emission-Computed, Single-Photon; D014103:Torticollis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D007457:Iodine Radioisotopes; D026901:Membrane Transport Proteins; D010880:Piperidines; C493459:SLC18A3 protein, human; D013764:Tetrahydronaphthalenes; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins; C065043:5-iodobenzovesamicol