Involvement of the subacromial bursa in impingement syndrome of the shoulder as judged by expression of tenascin-C and histopathology.
Our aim was to evaluate bursal involvement at different stages of the impingement syndrome as judged by conventional histopathological examination and expression of tenascin-C, which is known to reflect active reparative processes in different tissues and disorders. Samples of subacromial bursa were taken from 33 patients with tendinitis, 11 with a partial tear and 18 with a complete tear of the rotator cuff, and from 24 control shoulders. We assessed the expression of tenascin-C, the thickness of the bursa, and the occurrence and degree of fibrosis, vascularity, haemorrhage and inflammatory cells. The expression of tenascin-C was significantly more pronounced in the complete tear group (p < 0.001) than in the partial tear, tendinitis or control groups. It was more pronounced in the tendinitis group than in the control group (p = 0.06), and there was more fibrosis in all the study groups than in the control group. The changes in the other parameters were not equally distinctive. Expression of tenascin-C did not correlate with the conventional histopathological parameters, suggesting that these markers reflect different phases of the bursal reaction. Tenascin-C seems to be a general indicator of bursal reaction, being especially pronounced at the more advanced stages of impingement and this reaction seems to be an essential part of the pathology of impingement at all its stages.
Hyvönen
P
P
Department of Orthopaedic and Trauma Surgery, Oulu University Hospital, Oulu, Finland.
Melkko
J
J
Lehto
V P
VP
Jalovaara
P
P
D000328:Adult; D015415:Biomarkers; D002061:Bursa, Synovial / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D002062:Bursitis / Q000150:complications; D018450:Disease Progression; D005260:Female; D005355:Fibrosis; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D019534:Shoulder Impingement Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D019063:Tenascin / Q000378:metabolism*; D052256:Tendinopathy / Q000150:complications / Q000378:metabolism
D015415:Biomarkers; D019063:Tenascin