Absorption of L-lysine diatrizoate from the gastrointestinal tract: the effect of surgery, inflammation, and neoplasia.
OBJECTIVE
To ascertain whether the absorption of L-lysine diatrizoate, a sodium-free salt of the contrast-giving diatrizoic acid from the gastrointestinal tract is increased by surgery, inflammation, and neoplasia.


METHODS
The prospective study comprised 32 patients who were undergoing radiological examination of the upper gastrointestinal tract with a contrast medium containing L-lysine diatrizoate and 52 further patients who were undergoing examination of the lower gastrointestinal tract in the same way. The concentration of diatrizoic acid was determined by high-pressure liquid chromatography in blood samples taken before and immediately after the radiological examinations. The results were examined in terms of sex, age, surgical history, and any evidence of inflammatory or neoplastic diseases.


RESULTS
The serum diatrizoic acid concentration in patients tested after oral administration was 3.62 microg/ml. In patients who had undergone operation the titer was lower than in those who had not been operated on. Serum diatrizoic acid concentration in patients tested after rectal administration was 0.30 microg/ml. In patients suffering from inflammatory conditions or neoplasms the titer was significantly higher than in the other patients.


CONCLUSIONS
The L-lysine salt of diatrizoic acid is absorbed in larger amounts from the upper gastrointestinal tract than from the lower. Absorption is not increased after surgical operations on the viscera. However, inflammatory conditions and neoplasms involving the large bowel increase the uptake of the contrast medium from the intestine.
Golder
Werner
W
Department of Clinical Radiology, DRK Kliniken Berlin Westend, Spandauer Damm 130, 14050 Berlin, Germany. radiologie@drk-kliniken-westend.de
Dietz
Gerhard
G
Rittinghaus
Klaus
K
Weinberg
Peter
P
Jarosch
Michael
M
D000005:Abdomen / Q000601:surgery*; D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D003973:Diatrizoate / Q000008:administration & dosage / Q000378:metabolism*; D004064:Digestive System / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007408:Intestinal Absorption; D007414:Intestinal Neoplasms / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012737:Sex Factors
D003287:Contrast Media; D003973:Diatrizoate; D008239:Lysine