title: Dental practice implications of prion diseases.
abstract: This review article discusses dental practice implications of prion diseases, including Creutzfeldt-Jakob disease. The current universal precautions used for infection control in dentistry do not inactivate infectious prions. There is a theoretical, yet real risk of prion disease transmission through dental treatment, although the magnitude of that risk has not yet been determined. Medical, family, and travel histories can demonstrate the need for implementing improved levels of infection control. Best practices include the following: For certain cases, single-use disposable dental instruments should be used. Those instruments that are not disposable, should have a thorough physical cleaning, be soaked in hot 1N sodium hydroxide solution for 1 hour, and then autoclaved in a vacuum or porous-load autoclave at 134 degrees C to 138 degrees C for 18 to 20 minutes. Dental and other health care professionals need to understand prion diseases, and for best practice, consider implementing recommended changes to infection-control measures, since current practices do not destroy infectious prions.
authors.affiliation: Department of Restorative Dentistry and Biomaterials, University of Texas Houston Health Science Center, Dental Branch, Houston, Texas, USA. Richard.D.Bebermeyer@uth.tmc.edu
authors.forename: Richard D
authors.initials: RD
authors.lastname: Bebermeyer
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Powell
authors.forename: Martin H
authors.initials: MH
authors.lastname: Hobdell
authors.forename: Elisa M
authors.initials: EM
authors.lastname: Durban
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology; D003762:Dental Instruments; D004202:Disinfectants / Q000627:therapeutic use; D004209:Disposable Equipment; D006801:Humans; D019552:Infection Control, Dental / Q000379:methods; D017096:Prion Diseases / Q000517:prevention & control* / Q000635:transmission; D011328:Prions / Q000502:physiology; D012307:Risk Factors; D012972:Sodium Hydroxide / Q000627:therapeutic use; D013242:Sterilization / Q000379:methods; D016635:Universal Precautions
chemical_list: D004202:Disinfectants; D011328:Prions; D012972:Sodium Hydroxide