title: [Laboratory diagnosis of immunoglobulin deficiencies].
abstract: This review deals with the diagnostics of immunoglobulin defects. The development of methods used to detect and quantitate concentrations of immunoglobulins and their subclasses was shortly discussed; following by the role of antibodies in the host defence. Seven out of the ten main immunodeficiencies with the prevalence of antibody defects were then delineated. The diagnostics of humoral immunodeficiencies was illustrated by the example of three boys with hypogammaglobulinemia and three children with common variable immunodeficiency. Percentages of B lymphocytes varied, independent with the very decreased concentrations of immunoglobulin. Concentrations of IgG, IgA, IgM, IgE and IgG subclasses in healthy children of ages from birth to 16 years, were presented in the tables.
authors.affiliation: Zakład Mikrobiologii i Immunologii Klinicznej, Instytutu Pomnika-Centrum Zdrowia Dziecka w Warszawie. kmadalinski@wp.pl
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Madaliński
authors.forename: Hanna
authors.initials: H
authors.lastname: Gregorek
authors.forename: Krystyna
authors.initials: K
authors.lastname: Chrzanowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Michałkiewicz
authors.forename: Ewa
authors.initials: E
authors.lastname: Bernatowska
mesh_terms: D000293:Adolescent; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000145:classification / Q000302:isolation & purification; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D012016:Reference Values
chemical_list: D007136:Immunoglobulins