The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release.
Bäck
Magnus
M
National Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Norel
Xavier
X
Walch
Laurence
L
Gascard
Jean-Pierre
JP
Dahlén
Sven-Erik
SE
Brink
Charles
C
D000328:Adult; D000368:Aged; D003545:Cysteine; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D017997:Leukotriene C4 / Q000494:pharmacology*; D015289:Leukotrienes / Q000502:physiology*; D008175:Lung Neoplasms / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology*
D015289:Leukotrienes; D017997:Leukotriene C4; D003545:Cysteine; D007213:Indomethacin