title: Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity.
abstract: A new methoxylated naphthyl butenone, guieranone A (1), was isolated from the leaves of Guiera senegalensis. Its structure was elucidated as (2E)-1-(1,3,6,8-tetramethoxy-2-naphthyl)but-2-en-1-one, on the basis of spectroscopic data. Also isolated were two known naphthopyrones, 5-methyldihydroflavasperone (2) and 5-methylflavasperone (3). Guieranone (1) exhibited potent antifungal activity against Cladosporium cucumerinum and is the first naphthyl ketone derivative to have been isolated from the family Combretaceae.
authors.affiliation: Centro de Estudos de Ciências Farmacêuticas, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Lisbon, Av. das Forças Armadas, 1649-019 Lisbon, Portugal.
authors.forename: Olga
authors.initials: O
authors.lastname: Silva
authors.forename: Elsa T
authors.initials: ET
authors.lastname: Gomes
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002074:Butanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects*; D029764:Combretaceae / Q000737:chemistry*; D016701:Guinea; D016488:Medicine, African Traditional; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D002074:Butanones; D009281:Naphthalenes; C476838:guieranone A