[The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure].
OBJECTIVE
To investigate serum resistin concentration in essential hypertension patients and the relationship between serum resistin level and body fat content, plasma glucose concentration, and blood pressure.


METHODS
Fasting serum resistin concentrations were measured with enzyme immunoassay in 71 cases (including 33 men and 38 women), and oral glucose tolerance test and insulin release test were performed in all cases for calculating glucose area under the curve (AUC(G)), the ratio of change in insulin to change in glucose during the first 30 min after glucose ingestion (Delta I(30)/Delta G(30)) and insulin sensitivity index (ISI) according to Cederholm's formula. Systolic pressure (SBP), diastolic pressure (DBP), height, body weight, waist circumference and hip circumference were measured to calculate body mass index (BMI), body fat percentage (BF%) and waist-hip ratio (WHR).


RESULTS
Pearson analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.380, P < 0.001), BF% (r = 0.353, P < 0.01), ISI (r = -0.242, P < 0.05) and Delta I(30)/Delta G(30) (r = -0.298, P < 0.05), but not correlated with SBP, DBP, BMI and WHR. After adjustment for age and BMI, partial correlation analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.268, P < 0.05), Delta I(30)/Delta G(30) (r = -0.247, P < 0.05) and not correlated with ISI. A stepwise multiple linear regression analysis showed that resisitin was a significant independent predictor of AUC(G).


CONCLUSIONS
The strong correlation between fasting serum resistin levels and AUC(G), and BF% suggests a possibility that resistin link obesity to diabetes in humans.
Zhang
Jianliang
J
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Qin
Yongwen
Y
Zheng
Xing
X
Qiu
Jianli
J
Gong
Li
L
Mao
Hongjuan
H
Jia
Weiping
W
Guo
Jizhen
J
D001786:Blood Glucose; D001794:Blood Pressure; D003920:Diabetes Mellitus / Q000097:blood; D005215:Fasting / Q000378:metabolism; D005260:Female; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009765:Obesity / Q000097:blood; D052243:Resistin
D001786:Blood Glucose; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; C499624:RETN protein, human; C486574:RETNLB protein, human; D052243:Resistin