title: New sesterterpene metabolites from the Mediterranean sponge Cacospongia scalaris.
abstract: Two new sesterterpene metabolites, 16-acetoxy-dihydrodeoxoscalarin (1) and astakolactin (2), were isolated from the sponge Cacospongia scalaris, collected from the gulf of Astakos, Greece, along with furoscalarol (3) and deoxoscalarin (4), which have not been reported from C. scalaris in the past. The unpalatability of the sponge to fish was traced by field feeding assays to the fractions containing dihydrofurospongin-2. The structures of the new metabolites were elucidated by interpretation of their NMR data and high-resolution mass spectral measurements.
authors.affiliation: School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, University of Athens, Panepistimioupolis Zografou, Athens 157 71, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Tsoukatou
authors.forename: Helen
authors.initials: H
authors.lastname: Siapi
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D000818:Animals; D006115:Greece; D008522:Mediterranean Sea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C476836:16-acetoxy-dihydrodeoxoscalarin; D013729:Terpenes; C476837:astakolactin