In vivo changes in the intestinal lipid peroxidation and the crypt response to whole-body gamma irradiation in diethylnitrosamine-treated mice.
Studies were carried out to elucidate lipid peroxidation and crypt survival in the small intestinal mucosa of mice pretreated per os with diethylnitrosamine (DENA) and whole-body gamma irradiated. Results show that DENA lowered the total value of mean lethal radiation dose for crypt cells, and the agent was enable to sensitize crypts to gamma-rays. Present data suggest that gamma radiation- and/or DENA-induced pro-oxidant shift(s) is a risk factor for crypt survival.
Grudziński
Ireneusz P
IP
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004847:Epithelial Cells / Q000378:metabolism; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D000477:Alkylating Agents; D011837:Radiation-Protective Agents; D004052:Diethylnitrosamine