title: Case report: Kinetics of Epstein-Barr virus load in a bone marrow transplant patient with no sign of lymphoproliferative disease.
abstract: The kinetics of Epstein-Barr virus (EBV) load was measured in peripheral blood mononuclear cells of a severely immunocompromised allogeneic bone marrow recipient child, in conditions not associated with lymphoproliferative disease. The viral doubling time was 46.4 hr. The study permitted monitoring EBV clearance from blood, when the anti-rejection therapy was interrupted. Likely, this is the first accurate kinetic assessment of EBV load increasing phase in a clinical context marked by the absence of an overt post-transplant lymphoproliferative disease. According to these data gamma-herpesviruses behave like beta-herpesviruses in being capable of rapid growth.
authors.affiliation: Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padova, Italy.
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Biasolo
authors.forename: Arianna
authors.initials: A
authors.lastname: Calistri
authors.forename: Simone
authors.initials: S
authors.lastname: Cesaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gentile
authors.forename: Carlo
authors.initials: C
authors.lastname: Mengoli
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D004279:DNA, Viral / Q000097:blood; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis*; D019562:Viral Load
chemical_list: D004279:DNA, Viral