title: Three new cytotoxic sesterterpenes from a marine sponge Spongia sp.
abstract: Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan. sachiko@p.kanazawa-u.ac.jp
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Miura
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C476835:12-O-acetyl-16-O-methylhyrtiolide; C476834:12-O-deacetyl-12-epi-scalarin; C476833:12-O-deacetylscalarafuran; D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes