Immunogenicity and immunological priming of the serogroup a portion of a bivalent meningococcal A/C conjugate vaccine in 2-year-old children.
Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels.
Joseph
Helen
H
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, U.K. hjoseph@nw.phls.org.uk
Ryall
Robert
R
Bybel
Mike
M
Papa
Thomas
T
MacLennan
Jenny
J
Buttery
Jim
J
Borrow
Raymond
R
D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology* / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000276:immunology*; D009345:Neisseria meningitidis; D013997:Time Factors; D018074:Vaccines, Conjugate / Q000276:immunology*
D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate