Comparison of serum dexamethasone concentrations in cats after oral or transdermal administration using pluronic lecithin organogel (PLO): a pilot study.
The objective of this study was to measure and compare the serum concentrations of dexamethasone after oral and transdermal administration using pluronic lecithin organogel in six healthy cats. The study was designed as a crossover, in which the cats were randomly assigned to two groups. The cats received a single dose (0.05 mg kg(-1)) of dexamethasone either orally or transdermally on the inner pinna. Blood samples were taken at 0, 5, 15, 30, 60, 90 and 120 min, and 3, 4, 6, 8, 12 and 24, 48 and 72 h post dexamethasone administration. A mean peak serum concentration of 30.1 ng mL(-1) was detected 15 min after oral administration. Serum concentrations were below detection limits by 24 h. In contrast, there was no significant increase in serum concentrations of dexamethasone after transdermal administration. In cats, transdermal administration of a single dose of dexamethasone did not result in significant serum concentrations compared to oral administration.
Willis-Goulet
Heather S
HS
Blanche Saunders Dermatology Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Schmidt
Bill A
BA
Nicklin
Constance F
CF
Marsella
Rosanna
R
Kunkle
Gail A
GA
Tebbett
Ian R
IR
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002415:Cats / Q000378:metabolism*; D018592:Cross-Over Studies; D003907:Dexamethasone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D008081:Liposomes / Q000008:administration & dosage; D010865:Pilot Projects
D000893:Anti-Inflammatory Agents; D008081:Liposomes; D003907:Dexamethasone