Leporin B: a novel hexokinase II gene inducing agent from an unidentified fungus.
Leporin B (1), a novel demethylated analogue of leporin A (2), was isolated from a taxonomically unidentified fungal strain as part of an effort to discover compounds with the ability to increase expression levels of the enzyme hexokinase II. The structure was determined by spectral methods, including 1D and 2D NMR, and HRMS. The relative stereochemistry was assigned by NOESY experiments and coupling constants.
Zhang
Chaowei
C
OSI Pharmaceuticals Inc., 1 Bioscience Park Drive, NY 11735, Farmingdale, USA.
Jin
Liang
L
Mondie
Belinda
B
Mitchell
Scott S
SS
Castelhano
Arlindo L
AL
Cai
Weizhong
W
Bergenhem
Nils
N
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D004790:Enzyme Induction / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D006593:Hexokinase / Q000096:biosynthesis* / Q000235:genetics; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D032446:Myoblasts / Q000166:cytology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000187:drug effects; D051381:Rats; D015533:Transcriptional Activation / Q000187:drug effects*
D001578:Benzopyrans; D011728:Pyridones; D012333:RNA, Messenger; C479226:leporin B; D008156:Luciferases; D006593:Hexokinase