Psoriasis concomitant with chronic opisthorchiasis: ultrastructural changes in cell populations of gastroduodenal mucosa.
Pathological changes based on degeneration of epithelial structures predominantly with preserved typical cell differentiation, but with unstable epithelial secretory function were detected in biopsy specimens of gastroduodenal mucosa from patients with psoriasis associated with chronic opisthorchiasis. The progress of the disease led to atrophy of glandular components and augmented stromal sclerosis. The compensatory adaptive reactions were realized via hyperplasia and hyperfunction of preserved glandulocytes, appearance of mix-cells with polypotent secretory cycle, and high functional activity of capillaries.
Khardikova
S A
SA
Laboratory of Clinical Morphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@cyber.ma.nsc.ru
Aidagulova
S V
SV
Lapii
G A
GA
Nepomnyashchikh
D L
DL
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002454:Cell Differentiation; D002908:Chronic Disease; D004378:Duodenal Diseases / Q000209:etiology / Q000473:pathology; D004386:Duodenum / Q000473:pathology / Q000648:ultrastructure; D004847:Epithelial Cells / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007421:Intestine, Small / Q000469:parasitology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000150:complications* / Q000473:pathology; D011565:Psoriasis / Q000150:complications* / Q000473:pathology; D013272:Stomach Diseases / Q000209:etiology / Q000473:pathology