title: 188Re-labeled hydroxyapatite particles for radiation synovectomy.
abstract: A new procedure for labeling hydroxyapatite (HA) particles with 188Re for radiation synovectomy is described and standardized. The particles were labeled with 188Re in high yields (99%) in acidic medium. HA particle size remained unaffected by reaction conditions as checked by laser diffraction particle analyzer. 188Re-HA was found to be stable retaining 99% radiochemical purity after 4 days when stored in ascorbic acid solution (10mg/ml, pH 5). Intra-articular injection in rats revealed approximately 98% retention of 188Re-HA in the knee after 48-h pi.
authors.affiliation: Radiopharmaceuticals Section, Isotope Division, Bhabha Atomic Research Center, Mumbai, 400 085, India. ambi@magnum.barc.ernet.in
authors.forename: K
authors.initials: K
authors.lastname: Kothari
authors.forename: S
authors.initials: S
authors.lastname: Suresh
authors.forename: H D
authors.initials: HD
authors.lastname: Sarma
authors.forename: V
authors.initials: V
authors.lastname: Meera
authors.forename: M R A
authors.initials: MR
authors.lastname: Pillai
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry; D004355:Drug Stability; D006882:Hydroxyapatites / Q000737:chemistry* / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D007553:Isotope Labeling; D007834:Lasers; D010316:Particle Size; D011835:Radiation Protection / Q000295:instrumentation*; D011868:Radioisotopes / Q000737:chemistry* / Q000627:therapeutic use*; D016634:Radiosurgery / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry* / Q000627:therapeutic use*; D000074402:Synovectomy; D013997:Time Factors
chemical_list: D006882:Hydroxyapatites; D011868:Radioisotopes; D012211:Rhenium; D001205:Ascorbic Acid