The levelling effect of solvational imbalances in the reactions of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters.
A study of the reactions of oximate alpha-nucleophiles with diisopropylphosphorofluoridate (DFP) and two model phosphonates, has revealed either a levelling-off in reactivity or a bell-shaped behaviour in accordance with a critical decoupling of desolvation and bond formation (solvational imbalances); the relevance of these results to detoxification is emphasized.
Terrier
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F
Laboratoire SIRCOB, UMR 8086, Institut Lavoisier-Franklin, Université de Versailles, 45 Avenue des Etats-Unis 78035, Versailles Cedex, France
Le Guével
E
E
Chatrousse
A P
AP
Moutiers
G
G
Buncel
E
E
D005583:Fourier Analysis; D016252:Microscopy, Scanning Tunneling / Q000379:methods; D045322:Photosynthetic Reaction Center Complex Proteins / Q000737:chemistry*
D045322:Photosynthetic Reaction Center Complex Proteins