title: Acid infusion enhances duodenal mechanosensitivity in healthy subjects.
abstract: Duodenal acid has been suggested to be of importance for dyspeptic symptoms. We investigated the effects of acid on duodenal mechanosensitivity and antroduodenal motility in 10 healthy subjects before and during duodenal infusion of acid (0.1 N HCl) or water by using a combined barostat-manometry assembly. During acid infusion, increased sensitivity to balloon distension was seen, with reduced perception (P = 0.04) and discomfort thresholds (P = 0.06) and higher intensity of discomfort (P = 0.02) compared with water. Higher balloon volumes were seen during acid infusion, indicating decreased tone (P = 0.05). Large volume waves were more prevalent during acid than water infusion (P = 0.009). The acid infusion suppressed antral contractions (P = 0.04) and increased the number of contractions in the proximal duodenum (P = 0.02) compared with before the infusion. In conclusion, duodenal acid enhances mechanical sensitivity in the duodenum, affects gastroduodenal motor function, and might be of importance for dyspeptic symptoms.
authors.affiliation: Dept. of Internal Medicine, Division of Gastroenterology, Univ. Hospital Gasthuisberg, University of Leuven, Belgium.
authors.forename: Magnus
authors.initials: M
authors.lastname: Simrén
authors.forename: Rita
authors.initials: R
authors.lastname: Vos
authors.forename: Jozef
authors.initials: J
authors.lastname: Janssens
authors.forename: Jan
authors.initials: J
authors.lastname: Tack
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D002404:Catheterization; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage*; D008297:Male; D008365:Manometry; D008465:Mechanoreceptors / Q000502:physiology*; D010465:Perception; D011312:Pressure; D014867:Water / Q000008:administration & dosage
chemical_list: D014867:Water; D006851:Hydrochloric Acid