title: Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance.
abstract: Pleiotropy refers to a single genetic locus that affects more than one phenotypic trait. Pleiotropic effects of genetic loci are thought to play an important role in evolution, reflecting functional and developmental relationships among phenotypes. In a previous study, we examined pleiotropic effects displayed by quantitative trait loci (QTLs) on murine mandibular morphology in relation to mandibular structure and function. In replicating most of our previous QTLs and increasing our sample size, this study strengthens and extends our earlier results. As in our previous study, we find that QTL effects tend to be restricted to developmentally or functionally related traits. In addition, we examine patterns of differential dominance for pleiotropic QTL effects. Differential dominance occurs when dominance patterns for a single locus vary among traits. We find that multivariate overdominance is a common and substantial phenomenon, and may potentially provide an explanation for the persistence of heterozygosity in natural populations.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA. thehrich@artsci.wustl.edu
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Ehrich
authors.forename: Ty T
authors.initials: TT
authors.lastname: Vaughn
authors.forename: Safina F
authors.initials: SF
authors.lastname: Koreishi
authors.forename: Robin B
authors.initials: RB
authors.lastname: Linsey
authors.forename: L Susan
authors.initials: LS
authors.lastname: Pletscher
authors.forename: James M
authors.initials: JM
authors.lastname: Cheverud
mesh_terms: D000818:Animals; D005260:Female; D005799:Genes, Dominant; D006579:Heterozygote; D008126:Lod Score; D008297:Male; D008334:Mandible / Q000254:growth & development*; D051379:Mice; D009024:Morphogenesis / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D012727:Sex Characteristics