Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO).
The purpose of this study was to determine the carcinogenicity and retention of tritiated water (HTO) in mice. A two-part study was undertaken. In an HTO-incorporation study, both sexes of 12-day old C3H/HeN mice were i.p. injected with 3.70 MBq/pup of HTO and sacrificed 3 hr and 1, 3, 7, 14 days after HTO administration; in a carcinogenicity study, pups were given a single i.p. injection of HTO at doses of 0, 0.23, 0.92 and 3.70 MBq/mouse, and then observed for 14 months. The survival rates of both sexes slightly decreased upon increasing the HTO administered doses. The results indicated that the administration of HTO to infants led to a significant increase of liver tumors in male mice, but not in females. In female mice, ovarian tumors were observed for the high-dose group of injected HTO.
Yin
Hong
H
Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. yindahong@yahoo.co.jp
Bhattacharjee
Dilip
D
Roy
Goutum
G
Fujimoto
Nariaki
N
Nakatani
Tamaki
T
Ito
Akihiro
A
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006106:Granulosa Cell Tumor / Q000209:etiology; D008114:Liver Neoplasms, Experimental / Q000209:etiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010048:Ovarian Cysts / Q000209:etiology; D010051:Ovarian Neoplasms / Q000209:etiology; D015996:Survival Rate; D014018:Tissue Distribution; D014316:Tritium / Q000493:pharmacokinetics / Q000633:toxicity*; D014867:Water
D014867:Water; D014316:Tritium; C033961:tritium oxide