Parotid gland involvement in advanced AIDS.
OBJECTIVE
This study describes the involvement and the histological alterations found in the parotid glands of 100 patients who died with AIDS.


METHODS
Sex, age, CD4 cell count and clinical history were obtained from the files of 100 patients who died with AIDS. Histological analysis of the parotid glands was performed using H&E, Gomori-Grocott, Ziehl-Neelsen and Mucicarmine. Histological findings were grouped in reactive, infectious, cystic, neoplastic and concomitant lesions.


RESULTS
None of the patients presented complaints or symptoms related to salivary gland alterations prior to death. The mean age of the patients and CD4 cell count were 36.4 years and 76.07 cells microliter-1, respectively. Histological alterations of the parotid glands were found in 51% of the patients. The most common alteration was non-specific chronic sialadenitis (29 cases), followed by infectious conditions (22 cases). Mycobacteriosis was the most common infectious disease (10 cases), followed by cytomegalovirus (nine cases), cryptococcosis (three cases) and histoplasmosis (two cases). Lymphoepithelial cysts occurred in six cases, Warthin's tumor and non-Hodgkin Lymphoma in one case each.


CONCLUSIONS
These results indicate that infection and other lesions in the parotid glands are more frequent than hitherto described in the specialized literature in AIDS patients. Clinicians should consider parotid gland involvement, when evaluating disease extension in advanced AIDS patients.
Vargas
P A
PA
Department of Oral Pathology, Faculty of Odontology of Pieracicaba-University of Campinas, Piracicaba, Sao Paulo, Brazil. pavargas@fop.unicamb.br
Mauad
T
T
Böhm
G M
GM
Saldiva
P H N
PH
Almeida
O P
OP
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003453:Cryptococcosis / Q000150:complications; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006660:Histoplasmosis / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000150:complications; D010305:Parotid Diseases / Q000150:complications* / Q000382:microbiology / Q000473:pathology / Q000821:virology; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000150:complications; D010309:Parotitis / Q000150:complications