title: The seroprevalence of Helicobacter pylori infection in patients with obstructive sleep apnoea: a preliminary study.
abstract: We investigated the seroprevalence of Helicobacter pylori in patients with obstructive sleep apnoea. A prospective clinical study consisting of 19 patients, aged 23-72 years with confirmed obstructive sleep apnoea by overnight polysomnography, and 36 control subjects, aged 25-61 years with no history of obstructive sleep apnoea and gastroesophageal reflux complaints, was conducted. Titres of serum H. pylori IgG antibody were assayed by a serum enzyme-linked immunoabsorbant assay. The difference between the study and control groups was analysed by chi-squared test. Seventeen of the 19 patients (89.5%) were found to be H. pylori positive. However, 21 of the 36 control subjects (58.3%) were H. pylori positive. The seropositivity of H. pylori in obstructive sleep apnoea patients was found to be significantly higher than the control group (P = 0.017). The result of our study shows that there is a high association between H. pylori infection and obstructive sleep apnoea. This data may be important for future treatment strategies of the disease.
authors.affiliation: Mersin University, School of Medicine, Department of Otorhinolaryngology, Mersin, Turkey. muunal@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Unal
authors.forename: L
authors.initials: L
authors.lastname: Oztürk
authors.forename: C
authors.initials: C
authors.lastname: Oztürk
authors.forename: A
authors.initials: A
authors.lastname: Kabal
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000382:microbiology*; D014421:Turkey / Q000453:epidemiology