title: Interleukin-10 gene promoter polymorphism is not associated with schizophrenia in the Korean population.
abstract: The present study was aimed at examining the interleukin (IL)-10 gene promoter region polymorphic variants in patients with schizophrenia in the Korean population. Two hundred and thirty-three Korean patients diagnosed to have schizophrenia on the basis of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) and 181 normal healthy controls participated in the present study. The DNA was extracted from whole blood using proteinase K and the IL-10 gene promoter region was amplified by polymerase chain reaction. Gene typing was performed by restriction fragment length polymorphism and single-strand conformation polymorphism. Distribution of the alleles and haplotypes in patients with schizophrenia was not significantly different from those of controls. The present study suggests that IL-10 gene promoter polymorphism is not associated with the development of schizophrenia in the Korean population.
authors.affiliation: Department of Psychiatry, College of Medicine, Catholic University of Korea, St Mary's Hospital, Seoul, Korea.
authors.forename: Tae-Youn
authors.initials: TY
authors.lastname: Jun
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Hoon
authors.initials: H
authors.lastname: Han
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007723:Korea; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology
chemical_list: D016753:Interleukin-10