Sudden increase of vancomycin-resistant enterococcal infections in a Korean tertiary care hospital: possible consequences of increased use of oral vancomycin.
A sudden increase in vancomycin-resistant enterococci (VRE) infections was noted in 1998 in a tertiary care hospital in Korea. All of the VRE isolated in 1998 in the hospital were VanA type and most were multidrug-resistant Enterococcus faecium. The increase in VRE was probably due to the increased use of oral vancomycin to treat Clostridium difficile infections and clonal as well as horizontal spread. More restricted oral vancomycin use and stricter infection control measures are required to achieve a better control of the spread of VRE.
Shin
Jeong Won
JW
Department of Laboratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Yong
Dongeun
D
Kim
Myung Sook
MS
Chang
Kyung Hee
KH
Lee
Kyungwon
K
Kim
June Myung
JM
Chong
Yunsop
Y
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000187:drug effects; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D016521:Electrophoresis, Gel, Pulsed-Field; D016983:Enterococcus / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006786:Hospitals, Urban; D006801:Humans; D007723:Korea; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids; D016133:Polymerase Chain Reaction; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance / Q000235:genetics
D000900:Anti-Bacterial Agents; D014640:Vancomycin