In vitro susceptibility testing of four antibiotics against Borrelia burgdorferi: a comparison of results for the three genospecies Borrelia afzelii, Borrelia garinii, and Borrelia burgdorferi sensu stricto.
MICs and minimal bactericidal concentrations (MBCs) were evaluated for the four antibiotics azithromycin, amoxicillin, ceftriaxone, and doxycycline against the three main genospecies of Borrelia burgdorferi sensu lato. In MBC testing, statistically significant differences between the genospecies could be found in 7 out of 12 comparative evaluations (P < 0.05).
Sicklinger
Martin
M
Department of Dermatology, Ludwig-Maximilians University of Munich, D-80337 Munich, Germany.
Wienecke
Ralf
R
Neubert
Uwe
U
D000658:Amoxicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D025065:Borrelia burgdorferi / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D015748:Borrelia burgdorferi Group / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D002443:Ceftriaxone / Q000494:pharmacology; D015169:Colony Count, Microbial; D004318:Doxycycline / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D000658:Amoxicillin; D017963:Azithromycin; D004318:Doxycycline