title: The levelling effect of solvational imbalances in the reactions of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters.
abstract: A study of the reactions of oximate alpha-nucleophiles with diisopropylphosphorofluoridate (DFP) and two model phosphonates, has revealed either a levelling-off in reactivity or a bell-shaped behaviour in accordance with a critical decoupling of desolvation and bond formation (solvational imbalances); the relevance of these results to detoxification is emphasized.
authors.affiliation: Laboratoire SIRCOB, UMR 8086, Institut Lavoisier-Franklin, Université de Versailles, 45 Avenue des Etats-Unis 78035, Versailles Cedex, France
authors.forename: F
authors.initials: F
authors.lastname: Terrier
authors.forename: E
authors.initials: E
authors.lastname: Le Guével
authors.forename: A P
authors.initials: AP
authors.lastname: Chatrousse
authors.forename: G
authors.initials: G
authors.lastname: Moutiers
authors.forename: E
authors.initials: E
authors.lastname: Buncel
mesh_terms: D005583:Fourier Analysis; D016252:Microscopy, Scanning Tunneling / Q000379:methods; D045322:Photosynthetic Reaction Center Complex Proteins / Q000737:chemistry*
chemical_list: D045322:Photosynthetic Reaction Center Complex Proteins