Dosage compensation: an intertwined world of RNA and chromatin remodelling.
Dosage compensation mechanisms in flies and mammals provide an exquisite example of chromatin associated RNAs in chromosome-wide transcription regulation. Recent progress shows that chromatin modifications are also closely linked to these processes. Concerted action of the RNA/chromatin-modifying enzymes may play a crucial role in determining transcriptional output. Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition.
Akhtar
Asifa
A
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany. akhtar@embl-heidelberg.de
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002843:Chromatin / Q000378:metabolism*; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics; D006801:Humans; D012313:RNA / Q000378:metabolism*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics; D014960:X Chromosome / Q000378:metabolism
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002843:Chromatin; C106465:MNT protein, human; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012097:Repressor Proteins; C077885:XIST non-coding RNA; D012313:RNA