title: [Dynamic variation of serum and stool level of interleukin-2, interleukin-6 and interferon-alpha in children with rotavirus enteritis and its relation to clinical manifestations].
abstract: OBJECTIVE
  This study was conducted to observe dynamically the serum and stool level of IL-2, IL-6 and IFN-alpha with RV enteritis, and to analyse the relation of them and their relation to clinical manifestations.
  
  
  METHODS
  The double-antibody sandwich ELISA technique was applied.
  
  
  RESULTS
  The positive rate of RV in 119 enteritis cases was 63.0% and the peak month was November. These cytokines had different peak phases in the course of disease. The earliest cytokine which had peak phase was IFN-alpha, the last ones were serum and stool IL-2. There was a negative relation between stool IL-2 and IL-6 (P<0.01). There were positive relation between IL-2 and IFN-alpha, stool IL-6 and IFN-alpha, serum IL-2 and IL-6, stool IL-2 and the recovery time of the enteritis (P<0.01 or P<0.05). Serum and stool level of IL-2 and IFN-alpha had positive relation to the number of lymphocyte plus mononuclear cells (P<0.01 or P<0.05).
  
  
  CONCLUSIONS
  IL-2, IL-6 and IFN-alpha play important roles of immunoregulation in RV enteritis, and have close relation to clinical manifestations.
authors.affiliation: Hua Bei Oil Field Hospital, Hebei 062552, China.
authors.forename: Tiexiong
authors.initials: T
authors.lastname: Qi
authors.forename: Lixin
authors.initials: L
authors.lastname: Xie
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Junmin
authors.initials: J
authors.lastname: Wang
authors.forename: Huilan
authors.initials: H
authors.lastname: Chen
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhou
mesh_terms: D004751:Enteritis / Q000097:blood* / Q000821:virology; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D012400:Rotavirus Infections / Q000097:blood*
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D007371:Interferon-gamma