Acute myocardial infarction and cardiac arrest in a patient receiving paclitaxel.
A 68-year-old man suffered an acute myocardial infarction while receiving an intravenous infusion of paclitaxel. Coronary angiograms revealed only mild plaquing of the infarct-related artery without significant angiographic obstructions. The authors postulate that paclitaxel may have caused coronary vasospasm and myocardial infarction.
Nguyen-Ho
Phong
P
Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, USA. phongnguyenho@yahoo.com
Kleiman
Neal S
NS
Verani
Mario S
MS
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D017023:Coronary Angiography; D004562:Electrocardiography / Q000187:drug effects; D006323:Heart Arrest / Q000209:etiology* / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000150:complications* / Q000503:physiopathology; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel