title: Differences in the quantity of elastic fibres and collagen type I and type III in endopelvic fascia between women with stress urinary incontinence and controls.
abstract: The aim of this study was to evaluate whether differences in the quantity of elastic fibres, collagen type I and collagen type III in the endopelvic fascia occur with female stress urinary incontinence (SUI). A total of 54 patients participated in the study. They were divided into two groups (continent and incontinent) that were comparable with respect to age and parity. All patients underwent gynaecologic surgical procedures and biopsies from the endopelvic fascia were obtained. Histological slides were stained with haematoxylin and eosin and Masson trichrome or Weigert's techniques and immunohistochemistry for either collagen type I or type III were performed. The elastic fibres constituted 3.81+/-0.6% and 5.93+/-0.92% of the cross-sectional area of the endopelvic fascia in incontinent and control groups of patients, respectively. Collagen type I and type III were not significantly reduced in patients with SUI. Our results suggest that the quantity of elastic and collagen fibres in the endopelvic fascia does not play a significant role in continence.
authors.affiliation: Institute for Histology and Embryology, Medical Faculty, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. andrej.coer@mf.uni-lj.si
authors.forename: Andrej
authors.initials: A
authors.lastname: Cör
authors.forename: Matija
authors.initials: M
authors.lastname: Barbic
authors.forename: Bozo
authors.initials: B
authors.lastname: Kralj
mesh_terms: D000328:Adult; D024042:Collagen Type I / Q000378:metabolism*; D024061:Collagen Type III / Q000378:metabolism*; D004547:Elastic Tissue / Q000378:metabolism / Q000473:pathology; D005205:Fascia / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010388:Pelvis; D014550:Urinary Incontinence, Stress / Q000378:metabolism* / Q000473:pathology*
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III