Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix.
An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as an inhibitor of neural tumor growth. The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats and, when loaded on a slow-delivery polymer disk, caused the destruction of cultured human astroblastoma obtained after surgical biopsy.
Fernández-Mayoralas
Alfonso
A
Instituto de Química Orgánica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. iqofm68@iqog.csic.es
De La Figuera
Natalia
N
Zurita
Mercedes
M
Vaquero
Jesús
J
Abraham
Gustavo A
GA
San Román
Julio
J
Nieto-Sampedro
Manuel
M
D000117:Acetylglucosamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005260:Female; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008297:Male; D009368:Neoplasm Transplantation; D018302:Neoplasms, Neuroepithelial / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D011108:Polymers; D011409:Propylene Glycols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
C473670:2-acetamido-2-deoxy-6-O-(2,2-bis(hydroxymethyl)-3-hydroxypropyl)glucopyranoside; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006027:Glycosides; D011108:Polymers; D011409:Propylene Glycols; D000117:Acetylglucosamine