TCM-1: a nonlinear dynamical computational model to simulate cellular changes in the T cell system; conceptional design and validation.
Based upon a previously developed theory of dysregulative lymphoma pathogenesis, a computer model is designed in order to simulate cell changes occurring in disturbances of the T cell immune system and in lymphoproliferative diseases. The model is based upon the concept that factors identified as proliferation factors, differentiation factors and inhibition factors exert a network regulation upon development and function of the T cell system, and that selective disturbances of these factors may lead to hyperplastic, aplastic or neoplastic diseases. The resulting computer model (TCM-1) was validated by comparing it with data from human diseases such as acute HHV-6 (viral) infection, chronic persistent HHV-6 infection, progressive HIV1 infection and HTLV-1 infection, and comparing the simulation results with the actual cell data in the human patients. All these infections target the same T cell population (i.e. CD4 + T helper cells), yet cause different prototypical reactions (hyperplastic, aplastic, neoplastic). The described computer model, which was successfully used to simulate changes in the benign lymphoproliferative disease, Canale-Smith syndrome, will serve as the basis model for further supplementation to accommodate identified factorial influences such as by cytokines, chemokines and others.
Krueger
Gerhard R F
GR
Department of Internal Medicine, Department of Pathology & Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin St., MSB 2.246, Houston, Texas 77030 USA. Gerhard.Krueger@uth.tmc.edu
Brandt
Michael E
ME
Wang
Guanyu
G
Buja
L Maximilian
LM
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D003198:Computer Simulation; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1; D015490:HTLV-I Infections / Q000276:immunology; D015654:Herpesvirus 6, Human; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D018448:Models, Immunological; D017711:Nonlinear Dynamics; D019349:Roseolovirus Infections / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D014777:Virus Diseases / Q000276:immunology*