The expression of the apoptosis-suppressive gene bcl-2 in the tissue of colon carcinoma.
The role of bcl-2 in the pathogenesis of colorectal tumor were studied. The expression of bcl-2 in the colorectal carcinoma and incisional edge tissue of tumor was detected by using SABC method. The results showed that the positive rate of bcl-2 was 69.6% in colorectal carcinoma and 47.6% in the incisional edge tissue respectively, with the difference being very significant (P = 0.001). Bcl-2 positive rate was associated with Dukes' stage, but had nothing to do with histological classification. It was concluded that bcl-2 might play a significant role in the development of colorectal carcinoma.
Huang
Wenguang
W
Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Yao
Xuan
X
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D017209:Apoptosis / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics*; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology
D019253:Proto-Oncogene Proteins c-bcl-2