Zotepine in Huntington's disease.
The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS-I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS-I of 34 points on day 7 of treatment. The patient was stable for at least 12 weeks. The improvement includes all seven categories of the UHDRS-I, especially chorea, gait and oral function. This is the first description of zotepine in HD. Our findings suggest that zotepine is useful in the treatment of HD chorea. Controlled trials of its use in HD would be welcome.
Bonelli
Raphael M
RM
Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Bergstrasse 27, A-8021 Graz, Austria. rm.bonelli@nextra.at
Niederwieser
Gerald
G
Lahousen
Theresa
T
Hofmann
Peter
P
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002819:Chorea / Q000188:drug therapy; D003988:Dibenzothiepins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; C022172:zotepine