title: [High intensity focused ultrasound in the treatment of primary malignant bone tumor].
abstract: OBJECTIVE
  To develop a new noninvasive limb-salvaging method in the treatment of primary malignant bone tumor in the extremities.
  
  
  METHODS
  Forty-four patients with primary malignant bone tumor were treated by extracorporal high intensity focused ultrasound (HIFU) with or without chemotherapy, with a mean follow-up of 17.6 months.
  
  
  RESULTS
  The overall survival and complication rates were 84.1% and 18.2%. In 34 patients with stage II b disease, 30 were disease-free, with 2 died of tumor metastasis to brain and lung and 3 developed local recurrence. In 10 patients with stage III b disease, 5 survived with tumor, with 1 developed local recurrence and 5 died of lung metastasis. Thirty-six of 44 patients were > or = 15 points by Enneking system.
  
  
  CONCLUSIONS
  High intensity focused ultrasound combined with chemotherapy for primary malignant bone tumor in the extremity is proved to be effective and safe, preserving good function in the limbs. HIFU may possibly become a new limb-salvaging treatment for this tumor.
authors.affiliation: Clinical Center for Tumor Therapy, Second Hospital, Institute of Ultrasonic Engineering in Medicine, Chongqing University of Medical Sciences, Chongqing 400010, China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Chen
authors.forename: Zhibiao
authors.initials: Z
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zou
authors.forename: Jin
authors.initials: J
authors.lastname: Bai
authors.forename: Kequan
authors.initials: K
authors.lastname: Li
authors.forename: Fanglin
authors.initials: F
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014464:Ultrasonic Therapy; D036761:Ultrasound, High-Intensity Focused, Transrectal