Character of Immune Disturbances and Their Correction by Including the Interferon Inductor in Complex Therapy for Turboperitoneal Infertility Associated with Chlamydial Infection.
The character of immune disturbances was studied in women with tuboperitoneal infertility associated with a chlamydial infection. The immunological methods included a study of the population and subpopulation composition of peripheral blood lymphocytes (CD3, CD7, CD22, CD4, CD8, ratio CD4/CD8). The general hemolytic activity of the complement and main components of the complement (C1-C5), the level of IgA, IgM, IgG, the concentration of CIC, the content of IL-2 and its soluble receptor (sIL-2R) were determined in blood serum and in peritoneal fluid before and after treatment. A reduction in the absolute content of lymphocytes, T helpers, the number of B lymphocytes and their functions, the absence of activation of the T cell compartment, is detected. Evidence of this is provided by the low level of sIL-2R and the absence of a reliable rise of IL-2 in the blood serum and peritoneal fluid. The complex therapy of tuboperitoneal infertility associated with a chlamydial infection, with the obligatory inclusion of immunomodulators was effective and was accompanied by normalization of the majority of the immunity indices. Use of the interferon inductor ensured the maximum increase of the absolute content of the lymphocytes in circulation, without any pyrogenic reaction. This made interferon inductors preferable for therapeutic use in the case of this pathology.
Uzlova
Tatyana V.
TV
Chelyabinsk State Medical Academy, Chelyabinsk, Russia.
Teplova
Svetlana N.
SN
Medvedev
Boris I.
BI