title: Trisomy X in Philadelphia chromosome-negative cells during the course of Philadelphia chromosome-positive chronic myelocytic leukemia.
abstract: A Philadelphia chromosome-negative (Ph(-)) clone with trisomy X appeared in the bone marrow cells from a patient with Ph(+) chronic myelocytic leukemia in the chronic phase after hydroxyurea and interferon-alpha treatment.
authors.affiliation: First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan. a-hishi@med.nagoya-u.ac.jp
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Saito
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Emi
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D041321:Chromosomes, Human, X; D002999:Clone Cells / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014314:Trisomy
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D006918:Hydroxyurea