Androgen-independent prostate cancer: potential role of androgen and ErbB receptor signal transduction crosstalk.
In prostate cancer (PC), increasing evidence suggests that androgen receptor (AR) signalling is functional under conditions of maximal androgen blockade. PC cells survive and proliferate in the altered hormonal environment possibly by interactions between growth factor-activated pathways and AR signalling. The present review article summarizes the current evidence of this crosstalk and focuses on the interactions among the ErbB receptor network, its downstream pathways, and the AR. The potential role of this crosstalk in the development of androgen independence and in relation to antiandrogen therapy is discussed. Such interactions provide insight into possible complementary or additional strategies in the management of PC.
El Sheikh
Soha Salama
SS
Department of Histopathology, Imperial College, Hammersmith Hospital Campus, London, UK.
Domin
Jan
J
Abel
Paul
P
Stamp
Gordon
G
Lalani
El-Nasir
el-N
D000728:Androgens / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D008954:Models, Biological; D018739:Oncogene Proteins v-erbB / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D011471:Prostatic Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction
D000728:Androgens; D018739:Oncogene Proteins v-erbB; D011944:Receptors, Androgen; D019869:Phosphatidylinositol 3-Kinases