title: Successful treatment of subcutaneously disseminated aspergillosis with caspofungin acetate in an allogeneic peripheral blood stem cell transplantation patient.
abstract: We present a patient with acute myeloid leukaemia who developed subcutaneously disseminated aspergillosis after allogeneic peripheral stem cell transplantation (PSCT). Disseminated aspergillosis after stem cell transplantation has a high mortality despite treatment with amphotericin B or one of the azoles. Aspergillosis in our patient was refractory to amphotericin B and itraconazole but was successfully treated with caspofungin acetate.
authors.affiliation: Department of Haematology, VU University Medical Centre De Boelelaan, Amsterdam, The Netherlands.
authors.forename: M E D
authors.initials: ME
authors.lastname: Chamuleau
authors.forename: W
authors.initials: W
authors.lastname: Deenik
authors.forename: S
authors.initials: S
authors.lastname: Zweegman
authors.forename: A R
authors.initials: AR
authors.lastname: Jonkhoff
authors.forename: H L
authors.initials: HL
authors.lastname: Zaaijer
authors.forename: J J W M
authors.initials: JJ
authors.lastname: Janssen
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology; D000077336:Caspofungin; D004351:Drug Resistance; D054714:Echinocandins; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000628:therapy; D055666:Lipopeptides; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D010456:Peptides, Cyclic; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D000077336:Caspofungin