title: Leukocytoclastic vasculitis induced by use of glyburide: a case of possible cross-reaction of a sulfonamide and a sulfonylurea.
abstract: Drug-induced leukocytoclastic vasculitis (LCV) may present as the result of a single offending agent or more uncommonly, from a cross-reaction with a related medication. We describe a patient with sulfonamide allergy who developed LCV after exposure to a sulfonylurea. Sulfur-containing drugs may cross-react to induce LCV in susceptible individuals.
authors.affiliation: Dermatology Residency Program, State University of New York at Buffalo, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bukhalo
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Zeitouni
authors.forename: Richard T
authors.initials: RT
authors.lastname: Cheney
mesh_terms: D000328:Adult; D004232:Diuretics / Q000009:adverse effects* / Q000494:pharmacology*; D004347:Drug Interactions; D005905:Glyburide / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D013449:Sulfonamides / Q000009:adverse effects* / Q000494:pharmacology*; D013453:Sulfonylurea Compounds / Q000009:adverse effects* / Q000494:pharmacology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004232:Diuretics; D007004:Hypoglycemic Agents; D013449:Sulfonamides; D013453:Sulfonylurea Compounds; D005905:Glyburide