Effect of experimental diabetes and vagotomy on gastric emptying in rats.
The present study was performed to evaluate the rate of whole stomach emptying (WSE) in streptozotocin (STZ) induced rat model of diabetes mellitus by assessing the effect of bilateral gastric vagotomy in control as well as in experimental animals. Our results revealed that delayed emptying of solid foods by the stomach is demonstrated within 5 days of induction of diabetes in rats. After bilateral vagotomy, the later stages of WSE slowed down because of the diabetic state, most probably due to the direct effect of diabetes on the gastric antrum.
Mehta
Nalin
N
Department of Physiology, JIPMER, Pondicherry-605 006.
Veliath
Susheela
S
Thombre
D P
DP
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014629:Vagotomy, Proximal Gastric / Q000379:methods*; D014630:Vagus Nerve / Q000502:physiology*