title: Inhibition of the Low Density Lipoprotein-Induced Vascular Smooth Muscle Cell Growth by PPARgamma Ligands.
abstract: Low density lipoprotein has been shown to induce vascular smooth muscle cell proliferation and, therefore, to directly contribute to the development of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors involved in various cellular processes, such as cell cycle regulation and carcinogenesis. PPARgamma, the best characterized of the PPARs, plays a crucial role in the regulation of cell proliferation, adipocyte differentiation, insulin sensitivity, energy expenditure, development of atherosclerosis and carcinogenesis. In the present review we discuss recent findings showing that a new class of antidiabetic drugs, the PPARgamma ligands thiazolidinediones, might have potential antiatherosclerotic effects. (c) 2002 Prous Science. All rights reserved.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Gouni-Berthold
authors.forename: Agapios
authors.initials: A
authors.lastname: Sachinidis