title: CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
abstract: CD148 and CD27 are activation antigens involved in B cell and T cell activation and development. They have been recently proposed as markers of normal human memory B cells corresponding to the presence of somatically hypermutated IgV genes. We undertook an immunohistochemical study of CD148 and CD27 expression on neoplastic B cells in 116 cases of B cell non-Hodgkin's lymphoma. All cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, Burkitt's lymphoma, and the vast majority of cases of marginal zone B cell lymphoma and most cases of plasmacytoma/myeloma expressed CD148 and CD27. Follicular lymphoma and diffuse large B cell lymphoma were also immunoreactive for CD148 and CD27 with some variation and discordance in expression. Cases of precursor B-lymphoblastic lymphoma/leukemia did not express CD148 or CD27. Our findings demonstrate that CD148 and CD27 are expressed in a wide range of B cell non-Hodgkin's lymphomas, and, therefore, do not serve to distinguish between neoplastic cells of naïve and memory B cell derivation.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Henry Y
authors.initials: HY
authors.lastname: Dong
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Shahsafaei
authors.forename: David M
authors.initials: DM
authors.lastname: Dorfman
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism; D005803:Genes, Immunoglobulin; D006801:Humans; D007150:Immunohistochemistry; D007156:Immunologic Memory; D008223:Lymphoma / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis* / Q000235:genetics; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3; D014018:Tissue Distribution; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; C486288:PTPRJ protein, human; D017027:Protein Tyrosine Phosphatases; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3