In vitro cytotoxicity activity of Diosquinone, a naphthoquinone epoxide.
Diosquinone [1], a naphthoquinone epoxide previously isolated from the root bark of Diospyros mespiliformis (Hostch) and D. tricolor [Ebenaceae] is been assessed for cytotoxicity activity against ten cancer cell lines by standard NIH method. The ethno-pharmacological claim of this plant and the previously observed good antibacterial activity of this compound among the others isolated from this plant suggest its probable cytotoxicity activity. Diosquinone was observed to be very active against most of the cancer cell lines. It shows very good activity against all the cell lines tested with ED50 value ranging between 0.18 microg/ml. against Human Glioblastoma (U373) to 4.5 microg/ml. against Hormone dependent human prostrate cancer( LNCaP).
Adeniyi
B A
BA
Department of Pharmaceutical Microbiology and Clinical Pharmacy, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Robert
M F
MF
Chai
H
H
Fong
H H S
HH
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D029788:Diospyros; D018432:Drug Resistance, Multiple; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D009285:Naphthoquinones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D009285:Naphthoquinones; D010936:Plant Extracts; C090981:diosquinone