[Steroidal vasculitis in patients with bronchial asthma: specific features of platelet function and antithrombogenic vascular activity].
Severe forms of bronchial asthma (BA) are encountered now more and more frequently. Therefore, number of patients treated by course steroids in BA exacerbation and patients on continuous basic therapy with systemic glucocorticosteroids(GCS) grows. Pathogenesis of steroid vasculitis (SV) is though to be related with GCS effect on the skin, hemostasis and directly on the vessels. We studied platelet function and antithrombogenic activity of vascular wall (AAVW) in patients with steroid-dependent BA (SDBA) in development of cutaneous hemorrhagic syndrome (CHS). We examined 30 patients with SDBA and cutaneous vasculitis and 19 SDBA patients free of this vasculitis. A control group consisted of 29 healthy volunteers. Assessment of ADP-induced platelet aggregation, AAVW demonstrates enhanced functional activity of platelets and definite impairment of antithrombogenic endothelial activity in patients with SDBA and CHS. We came to the conclusion that AAVW affection is involved in pathogenesis of SV in SDBA patients.
Pebrov
A P
AP
Karoli
N A
NA
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001808:Blood Vessels / Q000187:drug effects / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013256:Steroids; D014657:Vasculitis / Q000139:chemically induced* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D013256:Steroids