title: [Gene mapping of a nonsyndromic hearing impairmint family].
abstract: OBJECTIVE
  To map the gene responsible for nonsyndromic hearing impairment in a consanguineous family.
  
  
  METHODS
  Firstly, X chromosome scanning was used to exclude X chromosome. Secondly, candidate gene analyzing and genome scanning were performed by homozygosity mapping. Then, additional markers flanking the tightly linked marker were tested to confirm linkage and decide the candidate region.
  
  
  RESULTS
  The nonsyndromic hearing impairment of this family was autosomal recessive. Twenty-five known genes were excluded. Autosomal genome scanning indicated that D17S1293 was tightly linked with disease gene. And further study mapped the disease gene to a 5.07 cM interval bounded by D17S1850 and D17S1818.
  
  
  CONCLUSIONS
  The disease gene of the family is mapped to a 5.07 cM interval between D17S1850 and D17S1818, which is a new locus of autosomal recessive nonsyndromic hearing impairment.
authors.affiliation: Department of Medical Genetics, Medical School of Shandong University, Jinan, Shandong, 250012 P. R. China. gongyaoqin@yahoo.com
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.forename: Yaoqin
authors.initials: Y
authors.lastname: Gong
authors.forename: Qiji
authors.initials: Q
authors.lastname: Liu
authors.forename: Bingxi
authors.initials: B
authors.lastname: Chen
authors.forename: Chenhong
authors.initials: C
authors.lastname: Guo
authors.forename: Jiangxia
authors.initials: J
authors.lastname: Li
authors.forename: Xiyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Guimin
authors.initials: G
authors.lastname: Gao
authors.forename: Haibin
authors.initials: H
authors.lastname: Zhou
authors.forename: Yishou
authors.initials: Y
authors.lastname: Guo
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D003241:Consanguinity; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree