title: Lupus-associated toxic epidermal necrolysis: a novel manifestation of lupus?
abstract: BACKGROUND
  Toxic epidermal necrolysis is an acute mucocutaneous reaction characterized by extensive cutaneous and mucosal sloughing and systemic involvement. It is generally associated with drug ingestion.
  
  
  OBJECTIVE
  We describe 2 patients who developed typical clinical and histopathologic features of toxic epidermal necrolysis with unusual subacute progression, absence of systemic involvement or high-risk drug ingestion, and features of lupus erythematosus.
  
  
  CONCLUSIONS
  We propose that this constellation of features represents a new entity not previously described. This entity may represent a more severe variant of Rowell's syndrome or, alternatively, a novel manifestation of lupus erythematosus
authors.affiliation: Division of Dermatology, Department of Medicine, University of Toronto.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Mandelcorn
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology