Effects of neonatal amygdala lesions on [125I] neurotensin binding in specific brain areas of adult rat.
Neurotensin has been implicated in the pathophysiology of schizophrenia. The neonatal amygdala lesion in rat has been proposed to be a neurodevelopmental model for some aspects of schizophrenia. [125I] Neurotensin binding was assessed in adult rats using in vitro autoradiography following a lesion of the basolateral amygdala at postnatal day 7 (Pd 7) or postnatal day 21 (Pd 21). The Pd 7 and Pd 21 lesions differentially affected neurotensin receptor densities in the hippocampal complex and (less pronounced) in the dopaminergic cell regions, implying a neurodevelopmental cause. These results may be of relevance for the involvement of neurotensin in the pathogenesis of schizophrenia.
Bouwmeester
Hans
H
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, Postbus 85060, 3508 AB Utrecht, The Netherlands.
Snapper
Jolanda
J
Ronken
Eric
E
Kruse
Chris G
CG
van Ree
Jan M
JM
D000679:Amygdala / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D007457:Iodine Radioisotopes; D009496:Neurotensin / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018028:Receptors, Neurotensin / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism
D007457:Iodine Radioisotopes; D018028:Receptors, Neurotensin; D009496:Neurotensin