title: Randomized prospective trial of the effect of induced hypergastrinemia on the prevention of pancreatic atrophy after pancreatoduodenectomy in humans.
abstract: OBJECTIVE
  To investigate whether gastrin has regenerative effect on the pancreas and in particular whether it prevents the atrophy of the distal pancreas after resection of pancreas in humans.
  
  
  BACKGROUND
  Although pancreatic regeneration after resection is well documented in animals, atrophy rather than regeneration of the distal remnant pancreas commonly occurs following pancreatoduodenectomy in humans. Of the many factors involving pancreatic regeneration, gastrin has been shown to have trophic effect on the pancreas in an animal model.
  
  
  METHODS
  Between March 1999 and May 2000, a randomized prospective study was performed in 56 patients who underwent pylorus-preserving pancreatoduodenectomy for periampullary neoplasms. Patients were allocated to either a lansoprazole group or a control group. The lansoprazole members were given oral lansoprazole (30 mg/d) over 12 weeks postoperatively to induce hypergastrinemia. During the study period, 19 patients were excluded for different reasons; in the end a total of 37 patients (lansoprazole, n = 18; control, n = 19) were eligible for study. The volume of the distal pancreas as determined using thin-sectioned spiral CT data, nutritional status, and endocrine (insulin level, glucose tolerance test) and exocrine function (stool elastase) of the pancreas and serum gastrin levels were measured before surgery and 3 months after surgery. The two groups were clinically comparable.
  
  
  RESULTS
  Serum gastrin level was elevated in the lansoprazole group. In this group, the mean volume of the distal pancreas was reduced by 10% after pylorus-preserving pancreatoduodenectomy, whereas severe pancreatic atrophy occurred in the control group. Postoperative insulin and stool elastase levels were higher in the lansoprazole group than in the control group.
  
  
  CONCLUSIONS
  This study is the first prospective randomized trial of induced hypergastrinemia on the regeneration of the pancreas in humans. It may be possible to use induced hypergastrinemia in the treatment or prevention of pancreatic insufficiency following resection or injury.
authors.affiliation: Department of Surgery, Seoul National University School of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Sun-Whe
authors.initials: SW
authors.lastname: Kim
authors.forename: Joon-Koo
authors.initials: JK
authors.lastname: Han
authors.forename: Sang-Jae
authors.initials: SJ
authors.lastname: Park
authors.forename: Youn-Chan
authors.initials: YC
authors.lastname: Park
authors.forename: Young
authors.initials: Y
authors.lastname: Joon Ahn
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000517:prevention & control; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010179:Pancreas / Q000473:pathology* / Q000503:physiopathology; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D005755:Gastrins