title: Metal-enhanced fluorescence: potential applications in HTS.
abstract: Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.
authors.affiliation: Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
authors.forename: Chris D
authors.initials: CD
authors.lastname: Geddes
authors.forename: Ignacy
authors.initials: I
authors.lastname: Gryczynski
authors.forename: Joanna
authors.initials: J
authors.lastname: Malicka
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Gryczynski
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Lakowicz
mesh_terms: D000465:Algorithms; D004247:DNA / Q000737:chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005453:Fluorescence; D006801:Humans; D008670:Metals / Q000737:chemistry*; D010600:Pharmacology; D011789:Quantum Theory
chemical_list: D008670:Metals; D004247:DNA