title: Malignant melanoma arising in a radiotherapy field: report of two cases and review of the literature.
abstract: We report 2 patients who developed melanoma or melanoma metastases in radiation fields 6 and 43 years after radiation therapy, respectively. One of the patients had received adjuvant hyperfractionated photon therapy for Ewing sarcoma, while the other patient had received X-ray therapy for a hemangioma. While postradiation secondary cancers with a long latency period are not uncommon, the development of melanoma is exceedingly rare.
authors.affiliation: Department of Dermatology and Allergy, Medical Faculty Charité, Humboldt University, Berlin, Germany. uwe.trefzer@charite.de
authors.forename: U
authors.initials: U
authors.lastname: Trefzer
authors.forename: C
authors.initials: C
authors.lastname: Voit
authors.forename: A
authors.initials: A
authors.lastname: Milling
authors.forename: H
authors.initials: H
authors.lastname: Audring
authors.forename: W
authors.initials: W
authors.lastname: Sterry
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy; D005260:Female; D006391:Hemangioma / Q000532:radiotherapy; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000556:secondary; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012512:Sarcoma, Ewing / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000209:etiology* / Q000556:secondary