title: First enantiodivergent Baeyer-Villiger oxidation by recombinant whole-cells expressing two monooxygenases from Brevibacterium.
abstract: Microbial Baeyer-Villiger oxidations of representative mesomeric ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium were investigated. The two enzymes displayed enantiodivergent biotransformations on an array of structurally diverse substrates, allowing access to some key lactone intermediates in natural compound synthesis.
authors.affiliation: Vienna University of Technology, Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163, Austria. mmihovil@pop.tuwien.ac.at
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
authors.forename: Florian
authors.initials: F
authors.lastname: Rudroff
authors.forename: Bernhard
authors.initials: B
authors.lastname: Müller
authors.forename: Peter
authors.initials: P
authors.lastname: Stanetty
mesh_terms: D001711:Biotransformation; D001951:Brevibacterium / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism; D007783:Lactones / Q000138:chemical synthesis* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D007527:Isoenzymes; D007659:Ketones; D007783:Lactones; D011994:Recombinant Proteins; D006899:Mixed Function Oxygenases