title: The Barbier-Grignard-type carbonyl alkylation using unactivated alkyl halides in water.
abstract: The aqueous Barbier-Grignard-type alkylation of aldehydes with unactivated alkyl iodides and bromides was developed. By using a combination of zinc and cuprous iodide, catalyzed by indium(I) chloride, we successfully added tertiary, secondary, and primary alkyl halides to various aromatic aldehydes in 0.07 M aqueous Na2C2O4. A mechanistic rationale for the success of the reaction has been proposed.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
authors.forename: Charlene C K
authors.initials: CC
authors.lastname: Keh
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wei
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li