A retrospective comparison between lamicel and gemeprost for cervical ripening before surgical interruption of first-trimester pregnancy.
To study the effect and complication rate of lamicel versus gemeprost as pretreatment to vacuum aspiration for the interruption of early pregnancy, the files of 622 medical records of women having a first-trimester abortion at Söder Hospital were studied retrospectively. Group A consisted of 317 women treated with lamicel in 1995 and Group B of 305 women treated with gemeprost in 1996. Complications were more common in Group A than in Group B (55 vs. 22; p < 0.05). Re-admission took place more often in Group A (25) than in Group B (6) (p < 0.05). The complications were more severe in Group A than in Group B. Using multivariate logistic regression analysis, the only impact factor for having a complication was the use of product for cervical priming. Gemeprost for preoperative treatment was found to render a fairly low rate of complications in this study, while complication rate was higher after treatment with lamicel.
Lindelius
Anna
A
Karolinska Institutet, Department of Obstetrics and Gynaecology at Stockholm Söder Hospital, S-118 83, Stockholm, Sweden. anna.lindelius@chello.se
Varli
Ingela Hulthén
IH
Hammarström
Margareta
M
D000028:Abortion, Induced; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D020070:Cervical Ripening / Q000187:drug effects*; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D011142:Polyvinyl Alcohol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011292:Premedication; D012086:Reoperation; D012189:Retrospective Studies; D013548:Sweden; D014595:Uterine Perforation / Q000209:etiology
C034860:Lamicel; C021182:gemeprost; D008278:Magnesium Sulfate; D011142:Polyvinyl Alcohol; D000527:Alprostadil