Cyclooxygenase-2 expression and activity are induced by amyloid-beta 1-42 in brain derived cells.
Bilunas
MacKenzie Hilfers
MH
Department of Pathology, University of Iowa, 1046 Medical Laboratories, Iowa City, IA 52242, USA.
Moore
Steven A
SA
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D001921:Brain / Q000201:enzymology*; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D051546:Cyclooxygenase 2; D004790:Enzyme Induction / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D019001:Nitric Oxide Synthase / Q000235:genetics; D052247:Nitric Oxide Synthase Type II; D010446:Peptide Fragments / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*
D016229:Amyloid beta-Peptides; D007527:Isoenzymes; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases