Nasal-type NK/T cell lymphoma of the orbit with distant metastases.
A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is reported. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis. Lymphoma cells were positive for CD56, cytotoxic molecules (granzyme B and TIA-1), and EBV. Despite local radiotherapy, the patient had a highly aggressive clinical course. A postmortem examination revealed distant metastases to the heart and lungs exhibiting angiocentric growth. TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit.
Kuwabara
Hiroko
H
Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.
Tsuji
Motomu
M
Yoshii
Yasuyoshi
Y
Kakuno
Yoshiteru
Y
Akioka
Toshikazu
T
Kotani
Takuya
T
Iwao
Noriaki
N
Hanafusa
Toshiaki
T
Ikeda
Tsunehiko
T
Mori
Hiroshi
H
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001706:Biopsy; D019002:CD56 Antigen / Q000032:analysis; D017809:Fatal Outcome; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D008175:Lung Neoplasms / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis
D019002:CD56 Antigen; D012367:RNA, Viral