title: Effects of cyclosporine-A on brain lipids and apolipoprotein E, J gene expression in rats.
abstract: Cyclosporine-A, an immunosuppressive agent, is known to produce complications such as seizures and encephalopathies. It alters peripheral lipid metabolism, but its effect on brain lipid metabolism is unknown. Alterations in brain cholesterol and phosphatidylcholine levels, as well as in apolipoproteine E and J gene expression, are reportedly involved in epilepsy and Alzheimer's disease (AD) and were here evaluated in rats following administration of cyclosporine-A for 3 weeks. Unesterified cholesterol and phospholipid brain levels were decreased by cyclosporine whereas apolipoprotein E and J mRNA levels were not altered in hippocampus or in cortex. These alterations in brain lipid metabolism are not similar to that reported in epilepsy or AD and exclude the involvement of apolipoprotein E and J over-expression in cyclosporine-mediated neurological disorders.
authors.affiliation: CNRS UMR 5094, Faculté de pharmacie, BP 14491, av Charles Flahaut, 34093, Montpellier cedex 5, France. pascale.montpied@ibph.phama.univ-montpl.fr
authors.forename: Pascale
authors.initials: P
authors.lastname: Montpied
authors.forename: Isabelle
authors.initials: I
authors.lastname: Batxelli
authors.forename: Marc
authors.initials: M
authors.lastname: André
authors.forename: Henri
authors.initials: H
authors.lastname: Portugal
authors.forename: Denis
authors.initials: D
authors.lastname: Lairon
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaërt
authors.forename: Françoise
authors.initials: F
authors.lastname: Chanussot
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000096:biosynthesis* / Q000235:genetics; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D051152:Clusterin; D016572:Cyclosporine / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006023:Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood / Q000145:classification; D008297:Male; D018832:Molecular Chaperones / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001057:Apolipoproteins E; D051152:Clusterin; D004791:Enzyme Inhibitors; D006023:Glycoproteins; D008055:Lipids; D018832:Molecular Chaperones; D012333:RNA, Messenger; D016572:Cyclosporine; D002784:Cholesterol