Proposal for a unified CCN nomenclature.
A proposal is put forth to unify the nomenclature of the CCN family of secreted, cysteine rich regulatory proteins. In the order of their description in the literature, CCN1 (CYR61), CCN2 (CTGF), CCN3 (NOV), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3) constitute a family of matricellular proteins that regulate cell adhesion, migration, proliferation, survival, and differentiation, at least in part through integrin mediated mechanisms. This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules.
Brigstock
D R
DR
Department of Surgery, Ohio State University, Colombus, Ohio 43205, USA.
Goldschmeding
R
R
Katsube
K-i
KI
Lam
S C-T
SC
Lau
L F
LF
Lyons
K
K
Naus
C
C
Perbal
B
B
Riser
B
B
Takigawa
M
M
Yeger
H
H
D055513:Connective Tissue Growth Factor; D055515:Cysteine-Rich Protein 61; D006801:Humans; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055514:Nephroblastoma Overexpressed Protein; D012958:Societies, Scientific; D009626:Terminology as Topic
C501848:CCN1 protein, human; C526317:CCN2 protein, human; C526319:CCN3 protein, human; D055515:Cysteine-Rich Protein 61; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055514:Nephroblastoma Overexpressed Protein; D055513:Connective Tissue Growth Factor