Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.
In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses of melanoma-bearing mice. Orthotopic inoculation with melanoma into the hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) of gabapentin (100-300 mg/kg) inhibited the allodynia and hyperalgesia, without effects on gross behaviors. An intraperitoneal injection (i.p.) of ketamine hydrochloride (30 mg/kg) produced partial inhibition in allodynia and hyperalgesia and prostate posture at 15 min after injection. Diclofenac sodium (10 and 30 mg/kg, i.p), mexiletine hydrochloride (20 mg/kg, i.p.), clonidine hydrochloride (0.1 mg/kg, i.p.) and suramin (100 mg/kg, i.p.) were without effects on allodynia and hyperalgesia. Subcutaneous injections of baclofen (3 mg/kg) and N(G)-nitro-L-arginine methyl ester (100 mg/kg) were also without effects. Repeated administration of gabapentin (150 mg/kg, p.o.) produced constant inhibitions, suggesting no analgesic tolerance. Gabapentin may be useful for the management of cancer pain.
Kuraishi
Yasushi
Y
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan. kuraisiy@ms.toyama-mpu.ac.jp
Iida
Yuko
Y
Zhang
Hong-Wei
HW
Uehara
Saori
S
Nojima
Hiroshi
H
Murata
Jun
J
Saiki
Ikuo
I
Takahata
Hiroki
H
Ouchi
Hidekazu
H
D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use*; D000588:Amines; D000818:Animals; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D006930:Hyperalgesia / Q000188:drug therapy; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000187:drug effects* / Q000502:physiology; D008545:Melanoma / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010812:Physical Stimulation / Q000379:methods; D023041:Xenograft Model Antitumor Assays / Q000379:methods; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin