title: Poly(HEMA)--based embolic material in endovascular surgery of liver.
abstract: Physico-chemical and medico-biological methods, including hematology and cytology, were used in an evaluation of properties of poly(2-hydroxyethyl methacrylate) (poly(HEMA))-based embolic material indicated in the occlusion of branches of hepatic artery of patients with focal alterations of the liver. The elastographic method helped in predicting mechanical properties of the hydrogel material. Poly(HEMA) was mechanically stable for endovascular applications, exhibited no significant loss in elasticity and possessed consistency resembling the soft tissue of the organism. Analysis of blood in contact with poly(HEMA) hydrogel provided a control of its biological inertness. Recently, 315 patients with focal alterations of the liver, including hemobilic hemorrhages and both primary and metastatic tumors, underwent endovascular occlusion with poly(HEMA) emboli as a pre-surgical step or as a simple occlusive measure. Compared with a direct operation on hemangiomatous injuries in the liver without endovascular occlusion, embolization with poly(HEMA) allowed to reduce 2.5-3 times bleeding in the operational zone. At the same time, the poly(HEMA) embolic material induced activation of general hemostatic reaction in the postembolization period.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Center for Cell Therapy and Tissue Replacements, Prague, Czech Republic. horak@imc.cas.cz
authors.forename: Daniel
authors.initials: D
authors.lastname: Horák
authors.forename: Alexander
authors.initials: A
authors.lastname: Sitnikov
authors.forename: Eldar
authors.initials: E
authors.lastname: Guseinov
authors.forename: Leonid
authors.initials: L
authors.lastname: Kokov
authors.forename: Mariya
authors.initials: M
authors.lastname: Titova
authors.forename: Arnold
authors.initials: A
authors.lastname: Adamyan
authors.forename: Klara
authors.initials: K
authors.lastname: Gumargalieva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006391:Hemangioma / Q000628:therapy*; D006461:Hemolysis; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects / Q000737:chemistry; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000628:therapy*; D008113:Liver Neoplasms / Q000628:therapy; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D011073:Polyamines / Q000009:adverse effects / Q000737:chemistry*; D011102:Polyhydroxyethyl Methacrylate / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry*; D012074:Remission Induction; D013921:Thrombocytopenia / Q000139:chemically induced; D013927:Thrombosis / Q000209:etiology
chemical_list: D020100:Hydrogels; D011073:Polyamines; C056971:poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer; D011102:Polyhydroxyethyl Methacrylate