title: The new histologic classification of chronic rhinosinusitis.
abstract: Two histologic patterns of disease are found in chronic rhinosinusitis. The first is dominated by eosinophilia and polypoid changes. Glandular hyperplasia and hypertrophy characterize the second. We present the evidence supporting the existence of these two patterns of disease and link these histologic patterns to the larger pathophysiologic processes that drive them. This histologic classification should be acknowledged both in the clinical setting and in laboratory research of chronic rhinosinusitis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Georgetown University, 1st Floor Gorman Building, 3800 Reservoir Road, NW, Washington, DC 20007-2197, USA. malekzas@gunet.georgetown.edu
authors.forename: Sonya
authors.initials: S
authors.lastname: Malekzadeh
authors.forename: John F
authors.initials: JF
authors.lastname: McGuire
mesh_terms: D002908:Chronic Disease; D004802:Eosinophilia / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D009298:Nasal Polyps / Q000473:pathology; D012220:Rhinitis / Q000145:classification* / Q000473:pathology*; D012852:Sinusitis / Q000145:classification* / Q000473:pathology*