Effect of Immune Interactions in Mother-Fetus System on Formation of Immune Response to Main Vaccinal Antigens.
Immune disturbances in the mother-fetus system are transformed to the postnatal period in the form of different kinds of immune pathology. Do these disturbances have an effect on the formation of postvaccinal immune response? A study was made in 81 children who were 14 months old. The immune response to diphtheria and measles antigen in those children was studied in the passive hemagglutination reaction. In order to detect immune disturbances in the mother-fetus system, their parents were tested using the methods: a mixed culture of lymphocytes (MLC) of the parents and determination of the blocking activity of the female serum (BAS) in MLC. The conducted study showed that there is a mutual relationship between the weak proliferative response in the MLC of the parents, combined with the absence of BAS, and low immune response to the diphtheria antigen. As regards measles vaccination, a close relationship between the strength of the immune response and immune reproductive disturbances has not been established. The obtained data may be used to predict the efficacy of alum precipitated DTP and DT vaccines.
Shabaldin
Andrey V.
AV
Kemerovo Scientific Center, Siberian Branch of Russian Academy of Sciences, Kemerovo, Russia.
Glushkov
Andrey N.
AN
Raikhel
Viktor V.
VV