Stem cells in the teleost retina: persistent neurogenesis and injury-induced regeneration.
The retina of the adult teleost fish is an important model for studying persistent and injury-induced neurogenesis in the vertebrate central nervous system. All neurons, with the exception of rod photoreceptors, are continually appended to the extant retina from an annulus of progenitors at the margin. Rod photoreceptors, in contrast, are added to differentiated retina only from a lineage of progenitors dedicated to making rods. Further, when the retina is lesioned, the lineage that produces only rods ceases this activity and regenerates retinal neurons of all types. The progenitors that supply neurons at the retinal margin and rod photoreceptors and regenerated neurons in the mature tissue originate from multipotent stem cells. Recent data suggest that the growth-associated neurogenic activity in the retina is regulated as part of the growth hormone/insulin-like growth factor-I axis. This paper reviews recent evidence for the presence of stem cells in the teleost retina and the molecular regulation of neurogenesis and presents a consensus cellular model that describes persistent and injury-induced neurogenesis in the retinas of teleost fish.
Otteson
Deborah C
DC
Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Johns Hopkins University School of Medicine, Wilmer Eye Institute, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Hitchcock
Peter F
PF
D000818:Animals; D005399:Fishes / Q000254:growth & development* / Q000502:physiology; D008959:Models, Neurological; D009416:Nerve Regeneration / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000254:growth & development*; D013234:Stem Cells / Q000166:cytology*