[Brain irradiation and phenytoin: a dangerous liaison?].
Three patients are presented, who developed a severe skin reaction after brain-irradiation and concomitant phenytoin treatment. A fourth patient from the databAse of the Swiss Drug Monitoring Center, showed a Stevens-Johnson-Syndrome after a severe electric shock and phenytoin treatment. Possible pathogenic mechanisms of these life-threatening complications and possible alternatives to the phenytoin treatment in irradiated patients are discussed.
Camartin
C
C
Departement Innere Medizin, Kantonsspital Chur.
Reinhart
W H
WH
Kuhn
M
M
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D000927:Anticonvulsants; D010672:Phenytoin