Confirmation of cervical neoplasia using a hand-held, lighted magnification device.
OBJECTIVE
The objective of this study was to estimate the sensitivity and specificity of visual inspection with acetic acid and magnification (VIAM) using the AviScope device to confirm high-grade cervical intraepithelial neoplasia or carcinoma.


METHODS
VIAM was performed on 142 women aged 18-50 years referred to three colposcopy clinics because of abnormal cervical cytology. Each woman then had a colposcopic examination with cervical biopsy when indicated.


RESULTS
The AviScope device identified 24 of the 40 women who had CIN 2, 3, or carcinoma, yielding a sensitivity of 60.0% (95% CI 43.4, 74.7). The AviScope correctly identified 60 of 87 women negative for dysplasia or cancer, yielding a specificity of 69.0% (95% CI 58.0, 78.2) compared with colposcopy and cervical histology.


CONCLUSIONS
VIAM using the AviScope device was moderately sensitive and specific for the confirmation of high-grade cervical lesions in women referred with abnormal cervical cytology.
Winkler
J L
JL
Program for Appropriate Technology in Health (PATH), Seattle, WA, USA. jwinkler@path.org
Tsu
V D
VD
Bishop
A
A
Scott
R
R
Sellors
J W
JW
D019342:Acetic Acid; D000293:Adolescent; D000328:Adult; D003127:Colposcopy; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D008875:Middle Aged; D010808:Physical Examination; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology
D007202:Indicators and Reagents; D019342:Acetic Acid