[Expression and significance of Fas and FasL protein in squamous cell carcinoma of larynx].
OBJECTIVE
To investigate the expression of Fas and FasL protein in squamous cell carcinoma of larynx (LSCC) and to evaluate its clinical significance.


METHODS
Using immunohistochemical method SABC, we studied the expression of Fas and FasL protein in 42 cases of paraffin-embedded LSCC tissues and in 10 cases of normal laryngeal tissues. The positive rates of Fas and FasL were compared with the pathological grade, clinical stage and cervical lymph node metastasis of LSCC.


RESULTS
The positive rates of Fas and FasL protein staining were 47.6% and 64.3% in 42 cases with LSCC, while they were 90.0% and 20.0% in the normal laryngeal tissues(P < 0.05) respectively. Fas was not related to the tumor grade and tumor stage (P > 0.05). However, Fas was significantly related to the metastasis(P < 0.05). On the other hand, FasL was positively related to the tumor grade, clinical stage and the metastasis(P < 0.05). No significant correlation has been noted between Fas and FasL.


CONCLUSIONS
The results suggest that the aberrant expression of Fas and FasL is closely related to the genesis and progression of LSCC. Fas and FasL might be a predictor for the prognosis of LSCC.
Shi
Lei
L
Department of Otorhinolaryngology, the 100th Hospital of PLA, Suzhou 215007.
Li
Guize
G
Zhu
Chunsheng
C
D000328:Adult; D000368:Aged; D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D019014:fas Receptor / Q000096:biosynthesis*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor