[Hypofractionated radiation therapy for the treatment of malignant melanoma and squamous cell carcinoma in dogs and cats].
This study describes the experience with hypofractionated radiation therapy of squamous cell carcinoma and melanoma in dogs and cats. A total dose of 32-48 Gray (Gy) was delivered once a week in 8 Gy fractions. 34 animals in which a complete surgical excision was impossible were treated. There was no tumor detectable macroscopically in 14 patients at the beginning of radiation therapy. In 20 animals the median volume of the tumor was 9.9 cm3. The median survival times and the local tumor control of squamous cell carcinoma of the oral and nasal cavities and of the body are comparable to results which were reached with a Monday-Wednesday-Friday scheme. For the treatment of Melanoma the hypofractionated radiation therapy is first choice. There are no significant side effects. Late side effects did not occur. 88% of the owners are satisfied with this kind of treatment and would choose it again.
Kinzel
Sylvia
S
Institut für Versuchstierkunde, Universitätsklinikums Aachen. skinzel@ukaachen.de
Hein
Sven
S
Stopinski
Thaddeus
T
Koch
Johannes
J
Buecker
Arno
A
Treusacher
Hans-Peter
HP
Schmachtenberg
Axel
A
Jansen
Thomas
T
Eble
Michael
M
Küpper
Wernen
W
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000401:mortality / Q000532:radiotherapy*; D002415:Cats; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D016019:Survival Analysis; D016896:Treatment Outcome