Follicular, papillary, and "hybrid" carcinomas of the thyroid.
The existence of well-differentiated thyroid tumors sharing the clinicopathologic features of follicular and papillary carcinoma is discussed using the so-called diffuse (multinodular) form of the follicular variant of papillary carcinoma as a paradigm. Although the concept of a hybrid carcinoma of the thyroid is intellectually very appealing, we conclude that there is not (yet) enough reliable genotypic or phenotypic evidence to support utilization of such a term.
Castro
Patrícia
P
IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.
Fonseca
Elsa
E
Magalhães
João
J
Sobrinho-Simões
Manuel
M
D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases