Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice.
This study was conducted to evaluate the effect of Dai-kenchu-to on chlorpromazine-induced hypoperistalsis in mice. Oral administration of Dai-kenchu-to (30-300 mg/kg) dose-dependently improved small intestinal and distal colonic propulsion decreased by chlorpromazine (3 mg/kg, p.o.). Although the improvement of small intestinal propulsion due to Dai-kenchu-to was partially inhibited by atropine (1 mg/kg, s.c.), this action was completely inhibited by the concomitant administration of lorglumide (10 mg/kg, i.p.), a CCKA receptor antagonist. The distal colonic propulsion-improving effect of Dai-kenchu-to was abolished by atropine (1 mg/kg, s.c.). When the effects of the respective components of Dai-kenchu-to were evaluated, oral administration of Zanthoxylum Fruit improved both delayed small intestinal and distal colonic propulsion caused by chlorpromazine. On the other hand, Malt Sugar was effective against only delayed small intestinal propulsion. The action of Zanthoxylum Fruit was completely inhibited by atropine (1 mg/kg, s.c.), and the effect of Malt Sugar was inhibited by lorglumide (10 mg/kg, i.p.). These results demonstrated that Dai-kenchu-to improves chlorpromazine-induced hypoperistalsis via cholinergic systems and that Zanthoxylum Fruit is the main contributor to this action of Dai-kenchu-to. In addition, endogenous CCK due to Malt Sugar may also contribute to this effect of Dai-kenchu-to.
Satoh
Kazuko
K
Kampo & Pharmacognosy Laboratory, R&D Division, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.
Kase
Yoshio
Y
Yuzurihara
Mitsutoshi
M
Mizoguchi
Kazushige
K
Kurauchi
Kouji
K
Ishige
Atsushi
A
D000109:Acetylcholine / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002746:Chlorpromazine / Q000037:antagonists & inhibitors*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D005746:Gastric Emptying / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D005894:Panax; D010528:Peristalsis / Q000187:drug effects*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011377:Proglumide / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D032106:Zanthoxylum; D030521:Zingiberaceae
D004364:Pharmaceutical Preparations; D010936:Plant Extracts; C121414:dai-kenchu-to; D011377:Proglumide; C048181:lorglumide; D000109:Acetylcholine; D002746:Chlorpromazine; D004298:Dopamine