title: [Efficacy of cyclines in agammaglobulinemia arthritis].
abstract: Five to 40% of patients with agammaglobulineamia develop joint manifestation consisting of septic arthritis or aseptic arthritis of unclear pathogenesis. Intravenous gamma-globulin therapy seems effective on the better condition but is burden-some and expensive. We report the case of a 31-year old woman, having a common variable immunodeficiency that has a chronic oligoarthritis seronegative and not warping. Substitutive treatment with gamma-globulins resulted in a poor improvement. Blood Lymphocyte immunotyping ans analysis of synovial fluid showed high levels of CD8 with a low CD4/CD8 ratio. Synovial biopsy revealed a non specific synovitis with an lymphoid aggregates with a significant predominance of CD8 cells and suspicion of mycoplasm, only after centrifugation, justifying PCR techniques. Doxycycline therapy was effective in relieving the joint symptoms with six month recession.
authors.affiliation: Service de médecine interne, l'EPS Habib Thameur.
authors.forename: Samir
authors.initials: S
authors.lastname: Kochbati
authors.forename: Fatma
authors.initials: F
authors.lastname: Boussema
authors.forename: Naziha
authors.initials: N
authors.lastname: Khamassi
authors.forename: Fatma
authors.initials: F
authors.lastname: Ben Dahmane
authors.forename: Golsom
authors.initials: G
authors.lastname: Ben Amor
authors.forename: Samir
authors.initials: S
authors.lastname: Ben Rhouma
authors.forename: Ouahida
authors.initials: O
authors.lastname: Cherif
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ben Ayed
authors.forename: R
authors.initials: R
authors.lastname: Kastalli
authors.forename: Lilia
authors.initials: L
authors.lastname: Rokbani
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D003241:Consanguinity; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D016130:Immunophenotyping; D016133:Polymerase Chain Reaction; D013582:Synovial Fluid / Q000166:cytology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous; D004318:Doxycycline