title: Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases.
abstract: Negative correlation between serum IgE levels and production of IFN-gamma by lymphocytes and positive correlation between serum IgE levels and production of IL-4 by lymphocytes was detected in 12 children with allergic asthma and recurrent respiratory diseases. Deficiency of reduced glutathione in whole blood and some disorders in phagocytic and oxidative burst activity of monocytes were observed in these children. Use of reduced glutathione, L-cysteine and anthocyane (Recancostat, Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. Positive clinical results were lasted during 6 months.
authors.affiliation: Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev, Ukraine. chernyshov@ukr.net
authors.forename: Viktor P
authors.initials: VP
authors.lastname: Chernyshov
authors.forename: Luydmila I
authors.initials: LI
authors.lastname: Omelchenko
authors.forename: Gernot
authors.initials: G
authors.lastname: Treusch
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Vodyanik
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Pochinok
authors.forename: Marina E
authors.initials: ME
authors.lastname: Gumenyuk
authors.forename: Gennady M
authors.initials: GM
authors.lastname: Zelinsky
mesh_terms: D000276:Adjuvants, Immunologic / Q000378:metabolism / Q000494:pharmacology*; D000293:Adolescent; D000872:Anthocyanins / Q000378:metabolism / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism*; D002648:Child; D003545:Cysteine / Q000378:metabolism / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D012120:Respiration Disorders / Q000188:drug therapy* / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000276:Adjuvants, Immunologic; D000872:Anthocyanins; D004338:Drug Combinations; D008070:Lipopolysaccharides; C121867:Recancostat compositum; D007371:Interferon-gamma; D005978:Glutathione; D003545:Cysteine