Genetic relationship of Borna disease virus isolates.
The infection of humans with Boma disease virus (BDV) is still a matter of debate. In a recent publication, we described a BDV (RW98) isolated from the blood of a psychiatric patient. The RNA of this virus differed more than 5% from that of the widely used strain He/80, which was supposed to represent our laboratory virus. Here, we show that the virus used in our laboratory was not He/80 and, furthermore, that RW98 has sequence identity to the laboratory strain. We also present data that BDV-specific nucleic acid detected in blood of the donor of the presumed RW98 isolate and one other patient differs from all known BDV-p24 sequences, arguing for the existence of BDV sequences in man.
Planz
Oliver
O
Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen. oliver.planz@tue.bfav.de
Rziha
Hanns-Joachim
HJ
Stitz
Lothar
L
D000818:Animals; D001483:Base Sequence; D001890:Borna Disease / Q000821:virology*; D001891:Borna disease virus / Q000235:genetics* / Q000302:isolation & purification; D002460:Cell Line; D004372:Ducks / Q000821:virology; D015673:Fatigue Syndrome, Chronic / Q000821:virology; D006801:Humans; D008322:Mammals / Q000821:virology; D001523:Mental Disorders / Q000821:virology; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics; D014766:Viremia / Q000821:virology*
D009698:Nucleoproteins; D010750:Phosphoproteins; D012367:RNA, Viral; D014764:Viral Proteins; C084757:p24 protein, Borna disease virus