title: Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity.
abstract: Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten patients with GPP who were treated at the same institution. The severity of this disease and its response to each therapeutic modality vary among patients. In some GPP is life-threatening, but in others it may show a benign, chronic course for a long period of time. Before starting treatment, a knowledge of the therapeutic efficacy and side effects of each drug used in the treatment of GPP is necessary. In our multicenter study, we compared the effectiveness of and adverse reactions to several systemically administered drugs. Following the development of a unique classification of the disease severity based on scoring the clinical symptoms and the laboratory findings, we propose here therapeutic guidelines for the treatment of GPP.
authors.affiliation: Department of Dermatology, Sensorium and Cutaneous Medicine, Tokai University School of Medicine, Isehara, Japan. umeume@is.icc.u-tokai.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Umezawa
authors.forename: A
authors.initials: A
authors.lastname: Ozawa
authors.forename: T
authors.initials: T
authors.lastname: Kawasima
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Terui
authors.forename: H
authors.initials: H
authors.lastname: Tagami
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Kawada
authors.forename: T
authors.initials: T
authors.lastname: Tezuka
authors.forename: A
authors.initials: A
authors.lastname: Igarashi
authors.forename: S
authors.initials: S
authors.lastname: Harada
mesh_terms: D006801:Humans; D017410:Practice Guidelines as Topic; D011565:Psoriasis / Q000503:physiopathology* / Q000628:therapy*; D012720:Severity of Illness Index