Neuroradiologic and clinical abnormalities in dementia of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease).
We describe a characteristic dementia patient diagnosed as diffuse neurofibrillary tangles with calcification (DNTC). Neuropsychologically, dementia, including a decline in memory retention and intelligence, and anomic aphasia were recognized. Imaging revealed circumscribed temporal dominant atrophy and calcification of the basal ganglia and cerebellum. SPECT and FDG-PET revealed a remarkable reduction of blood flow and metabolism in the temporal lobes; however, there is no reduction in the basal ganglia and cerebellum, and FDOPA-PET also disclosed no abnormalities. This suggests that calcification and neuronal degeneration occur independently in DNTC.
Ito
Yasuhiro
Y
Department of Neurology, Higashinagoya National Hospital, 5-101 Umemorizaka, Meito-ku, Nagoya, 465-8620, Aichi, Japan. yasuhiro.ito@mail.uni_wuerzburg.de
Kato
Takashi
T
Suzuki
Tomomi
T
Yokokawa
Yuki
Y
Aiba
Ikuko
I
Arahata
Yutaka
Y
Ito
Eiichi
E
Ito
Kengo
K
Yasuda
Takeshi
T
Sobue
Gen
G
D000368:Aged; D000849:Anomia / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D003704:Dementia / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology; D016874:Neurofibrillary Tangles; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed