title: Wnt-mediated axon guidance via the Drosophila Derailed receptor.
abstract: In nervous systems with bilateral symmetry, many neurons project axons across the midline to the opposite side. In each segment of the Drosophila embryonic nervous system, axons that display this projection pattern choose one of two distinct tracts: the anterior or posterior commissure. Commissure choice is controlled by Derailed, an atypical receptor tyrosine kinase expressed on axons projecting in the anterior commissure. Here we show that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules. Our results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events.
authors.affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, PO Box 85800, San Diego, California 92186, USA.
authors.forename: Shingo
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Randall D
authors.initials: RD
authors.lastname: McKinnon
authors.forename: Michelle
authors.initials: M
authors.lastname: Kokel
authors.forename: John B
authors.initials: JB
authors.lastname: Thomas
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002465:Cell Movement; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D010641:Phenotype; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C094492:DRL protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases