IgD-kappa myeloma: an unusual case.
A rare case of biclonal IgD-kappa and IgG-kappa myeloma is described. The patient initially presented with anemia, renal insufficiency, and proteinuria. The IgD-kappa, initially, was overlooked as a light chain; however, it decreased in serum concentration after treatment by approximately 90%, in contrast to the IgG-kappa that decreased in serum by approximately 40 % over a 9-yr period. Clinically, the patient responded well to treatment and improved greatly during this period. Practical recommendations are suggested in order to detect such cases.
Tharp
Amy M
AM
27157, USA.
Woodruff
Ralph D
RD
Shihabi
Zak K
ZK
D000368:Aged; D001797:Blood Protein Electrophoresis; D003362:Cost-Benefit Analysis; D006801:Humans; D007118:Immunoassay / Q000191:economics / Q000379:methods; D007072:Immunoglobulin D / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology*; D011379:Prognosis
D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains