title: A novel concept to activate enediynes for DNA cleavage.
abstract: A novel concept is presented to activate enediynes via a biscumulenic intermediate using photoinduced electron transfer (PET).
authors.affiliation: FB 8-OC1 (Chemie-Biologie), Universität Siegen, Adolf-Reichwein-Str, D-57068 Siegen, Germany. schmittel@chemie.uni-siegen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Schmittel
authors.forename: Giampietro
authors.initials: G
authors.lastname: Viola
authors.forename: Francesco
authors.initials: F
authors.lastname: Dall'Acqua
authors.forename: Guido
authors.initials: G
authors.lastname: Morbach
mesh_terms: D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D004247:DNA / Q000737:chemistry*; D004278:DNA, Superhelical / Q000737:chemistry*; D004579:Electron Transport; D004587:Electrophoresis, Agar Gel; D005609:Free Radicals / Q000737:chemistry; D010777:Photochemistry; D010957:Plasmids / Q000737:chemistry; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000480:Alkynes; D000903:Antibiotics, Antineoplastic; D004278:DNA, Superhelical; D005609:Free Radicals; D011084:Polycyclic Aromatic Hydrocarbons; D004247:DNA; C427203:calf thymus DNA