title: Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.
abstract: We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.
authors.affiliation: Obstetrics and Gynecology, The American University of Beirut Medical Center, New York, New York 10022, USA.
authors.forename: Muhieddine
authors.initials: M
authors.lastname: Seoud
authors.forename: Anwar
authors.initials: A
authors.lastname: Nassar
authors.forename: Ihab
authors.initials: I
authors.lastname: Usta
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mansour
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Salti
authors.forename: Khaled
authors.initials: K
authors.lastname: Younes
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D001656:Biliary Atresia / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D004064:Digestive System / Q000187:drug effects; D004065:Digestive System Abnormalities; D004933:Esophageal Atresia / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000188:drug therapy; D007231:Infant, Newborn; D008713:Methimazole / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013997:Time Factors; D014138:Tracheoesophageal Fistula / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole