Molecular cytogenetic analysis of a pleuropulmonary blastoma.
We report a case of pleuropulmonary blastoma with complex cytogenetic abnormalities, including trisomy 2, trisomy 8, dup(7), der(10) t(8; 10)(q13; q22), add(17), and double minutes (dmin). Fluorescence in situ hybridization FISH analysis demonstrated TP53 deletion and amplification of MYCN; the latter has not been reported in PPB.
Hong
Bo
B
Cytogenetics Laboratory, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
Chen
Zhong
Z
Coffin
Cheryl M
CM
Lemons
Richard
R
Issa
Bonnie
B
Brothman
Arthur
A
Zhou
Holly
H
D002675:Child, Preschool; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D020732:Cytogenetic Analysis; D005260:Female; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D018202:Pulmonary Blastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014314:Trisomy; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D016159:Tumor Suppressor Protein p53