title: Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase.
abstract: Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol. Demannosyl and/or dearabinitoyl roselipins were prepared chemically or enzymatically. Demannnosyl roselipins conserved the DGAT inhibitory activity, but the others lost the activity, indicating that the arabinitoyl fatty acid core is essential for eliciting the activity.
authors.affiliation: Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan. tomoda@lisci.kitasato-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Noriko
authors.initials: N
authors.lastname: Tabata
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D051048:Diacylglycerol O-Acyltransferase; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005227:Fatty Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D020462:Gliocladium / Q000737:chemistry*; D009005:Monosaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D009005:Monosaccharides; C401212:roselipin 1A; C401213:roselipin 2A; C472762:roselipin 3A; C472763:roselipin 3B; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase