Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus.
We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria).
Karras
Alexandre
A
Service de Néphrologie, Hôpital Saint-Louis, 75475 Paris cedex 10, France. alexandre.karras@sls.ap-hop-paris.fr
Lafaurie
Matthieu
M
Furco
André
A
Bourgarit
Anne
A
Droz
Dominique
D
Sereni
Daniel
D
Legendre
Christophe
C
Martinez
Frank
F
Molina
Jean-Michel
JM
D000138:Acidosis / Q000209:etiology; D000225:Adenine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D018500:Diabetes Insipidus, Nephrogenic / Q000209:etiology* / Q000473:pathology; D016903:Drug Monitoring; D005198:Fanconi Syndrome / Q000209:etiology* / Q000473:pathology; D006029:Glycosuria / Q000209:etiology; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects*; D011507:Proteinuria / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology* / Q000473:pathology; D000068698:Tenofovir
D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D000068698:Tenofovir; D003404:Creatinine; D000225:Adenine