title: Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
abstract: Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
authors.affiliation: Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: van der Walt
authors.forename: E R
authors.initials: ER
authors.lastname: Martin
authors.forename: W K
authors.initials: WK
authors.lastname: Scott
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: M A
authors.initials: MA
authors.lastname: Nance
authors.forename: R L
authors.initials: RL
authors.lastname: Watts
authors.forename: J P
authors.initials: JP
authors.lastname: Hubble
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: W C
authors.initials: WC
authors.lastname: Koller
authors.forename: K
authors.initials: K
authors.lastname: Lyons
authors.forename: R
authors.initials: R
authors.lastname: Pahwa
authors.forename: M B
authors.initials: MB
authors.lastname: Stern
authors.forename: A
authors.initials: A
authors.lastname: Colcher
authors.forename: B C
authors.initials: BC
authors.lastname: Hiner
authors.forename: J
authors.initials: J
authors.lastname: Jankovic
authors.forename: W G
authors.initials: WG
authors.lastname: Ondo
authors.forename: F H
authors.initials: FH
authors.lastname: Allen
authors.forename: C G
authors.initials: CG
authors.lastname: Goetz
authors.forename: G W
authors.initials: GW
authors.lastname: Small
authors.forename: F
authors.initials: F
authors.lastname: Mastaglia
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: J M
authors.initials: JM
authors.lastname: Stajich
authors.forename: M W
authors.initials: MW
authors.lastname: Booze
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: R A
authors.initials: RA
authors.lastname: Gibson
authors.forename: L T
authors.initials: LT
authors.lastname: Middleton
authors.forename: B L
authors.initials: BL
authors.lastname: Scott
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: J M
authors.initials: JM
authors.lastname: Vance
mesh_terms: D000368:Aged; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018570:Risk Assessment
chemical_list: D007527:Isoenzymes; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1; C478900:NAT2 protein, human