A novel concept to activate enediynes for DNA cleavage.
A novel concept is presented to activate enediynes via a biscumulenic intermediate using photoinduced electron transfer (PET).
Schmittel
Michael
M
FB 8-OC1 (Chemie-Biologie), Universität Siegen, Adolf-Reichwein-Str, D-57068 Siegen, Germany. schmittel@chemie.uni-siegen.de
Viola
Giampietro
G
Dall'Acqua
Francesco
F
Morbach
Guido
G
D000480:Alkynes / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D004247:DNA / Q000737:chemistry*; D004278:DNA, Superhelical / Q000737:chemistry*; D004579:Electron Transport; D004587:Electrophoresis, Agar Gel; D005609:Free Radicals / Q000737:chemistry; D010777:Photochemistry; D010957:Plasmids / Q000737:chemistry; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet
D000480:Alkynes; D000903:Antibiotics, Antineoplastic; D004278:DNA, Superhelical; D005609:Free Radicals; D011084:Polycyclic Aromatic Hydrocarbons; D004247:DNA; C427203:calf thymus DNA