[Immunoneuroendocrine communication network and homeostasis regulation: the use of hormones and neurohormones as immunotherapy].
The complex communication between the immune and neuroendocrine systems is bi-directional, and involves sharing different ligands and receptors in tissues and organs in vertebrate in general, and mammals in particular. It have been demonstrated that many hormones, neurohormones and neurotransmitters have profound effects on the immune system, and in turn, cytokines produced by cells of the immune system cause important changes in the neuroendocrine function. It has been shown in different animal models with induced and spontaneously occurring autoimmune diseases that alterations of the immunoendocrine interactions are involved in the breakdown of self tolerance, and by extend, the homeostasis. This review discusses the role of the neuroimmunoendocrine interactions in maintaining the homeostasis of mammals, and their role in the development of some autoimmune diseases. The finding that could exist a defective immunoneuroendocrine communication may lead to more specific therapy of several autoimmune human diseases.
Arteaga
Marcala
M
Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana, Iztapalapa, AP 55-535, 09340, México, D.F.
Chavarría
Anahí
A
Morales Montor
Jorge
J
D006706:Homeostasis / Q000502:physiology*; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D015213:Neuroimmunomodulation / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000627:therapeutic use*
D006728:Hormones; D018377:Neurotransmitter Agents