title: 3He MR imaging of porcine paranasal sinuses.
abstract: OBJECTIVE
  The aim of this study was to test the effectiveness of laser-hyperpolarized helium 3 (3He) as a contrast agent for magnetic resonance (MR) imaging of porcine paranasal sinuses.
  
  
  METHODS
  Imaging experiments were conducted on the heads of four 50-kg Yorkshire pigs after open sinus surgery was performed. Paranasal sinus MR images were obtained with laser-polarized 3He gas produced through the spin-exchange method. The gas was delivered into the sinuses through two 14-gauge plastic catheters inserted in the nostrils. The 3He MR images were then compared with spatially correlated proton MR images.
  
  
  RESULTS
  The porcine paranasal sinuses were adequately depicted by MR imaging with hyperpolarized 3He. The signal intensity of the paranasal sinuses on the 3He MR images was related to the size of the opening joining the sinuses to the nasal cavity and was clearly time dependent.
  
  
  CONCLUSIONS
  Hyperpolarized 3He MR imaging may be particularly useful for identifying the anatomic configuration of the paranasal sinuses, as well as for assessing sinus aeration. Further study of the time-dependence of 3He signal intensity may help increase understanding of gas exchange in the sinuses.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Bayview Medical Center, 3940 Eastern Ave, Bldg A5W, Room 595A, Baltimore, MD 21224, USA.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
authors.forename: David A
authors.initials: DA
authors.lastname: Roberts
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Looby
authors.forename: Johan
authors.initials: J
authors.lastname: Edvinsson
authors.forename: Aman
authors.initials: A
authors.lastname: Jalali
authors.forename: Rahim
authors.initials: R
authors.lastname: Rizi
mesh_terms: D000818:Animals; D003287:Contrast Media; D006371:Helium; D007554:Isotopes; D008279:Magnetic Resonance Imaging; D010256:Paranasal Sinuses / Q000033:anatomy & histology*; D013552:Swine
chemical_list: D003287:Contrast Media; D007554:Isotopes; D006371:Helium