title: [Studies on the safety and immunogenicity of lyophilized live attenuated measles-mumps-rubella combined vaccine].
abstract: OBJECTIVE
  To study the safety and immunogenicity of the measles-mumps-rubella combined vaccine (MMR) produced by Beijing Biological Product Institute.
  
  
  METHODS
  Children aged 10-12 years, 2-2.5 years and 8-12 months were selected to be vaccinated with Beijing MMR vaccine (test vaccine). Other groups of children with similar nature were vaccinated with measles vaccine, mumps vaccine and rubella vaccine while using imported MMR vaccine (control vaccine) as controls.
  
  
  RESULTS
  The safety of the Beijing MMR vaccine was confirmed after vaccinating 32 children above 2 years old. Among 104 children of 8-12 months were vaccinated with Beijing MMR vaccine, only 6.7% of the children had transient fever and 1.9% had signs of rashes but with no other signs observed. The positive seroconversion rates of measles, rubella and mumps anti-HI were 100%, 100% and 85.7% respectively. GMT also showed high lever.
  
  
  CONCLUSIONS
  The MMR vaccine (Beijing) had good safety and immunogenicity which might be used to be the bases enhance immunization of measles.
authors.affiliation: Henan Provincial Epidemic Prevention Station, Zhengzhou 450003, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Liu
authors.forename: Hanhua
authors.initials: H
authors.lastname: Fang
authors.forename: Zijian
authors.initials: Z
authors.lastname: Feng
authors.forename: Wanshen
authors.initials: W
authors.lastname: Guo
authors.forename: Chunming
authors.initials: C
authors.lastname: Dong
authors.forename: Wenping
authors.initials: W
authors.lastname: Zhang
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Ze
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005612:Freeze Drying; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects* / Q000276:immunology; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022542:Measles-Mumps-Rubella Vaccine; D014613:Vaccines, Attenuated