Effect of Ghrelin on catecholamine secretion in rat pheochromocytoma PC12 cells.
A novel peptide Ghrelin, found to be a ligand to growth hormone (GH) secretagogue receptor (GHS-R), exeterts to stimulates GH release from pituitary gland. Recently, it has been shown that ghrelin and its receptor are existed in a adrenal ground. At concentrations of 10 nM and over (10 nM, 100 nM, and 1 microM), ghrelin significantly inhibited basal dopamine release by 30, 32 and 34%, respectively (P < 0.05) in PC12 cells, suggesting that ghrelin may be involved in the mechanism of catecholamine regulation in chromaffin cells.
Nanmoku
Toru
T
Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Takekoshi
Kazuhiro
K
Ishi
Kiyoaki
K
Kawakami
Yasushi
Y
Isobe
Kazumasa
K
Shibuya
Shunsuke
S
Okuda
Yukichi
Y
Nakai
Toshiaki
T
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D054439:Ghrelin; D016716:PC12 Cells / Q000187:drug effects* / Q000378:metabolism*; D036361:Peptide Hormones / Q000494:pharmacology*; D051381:Rats
D054439:Ghrelin; D036361:Peptide Hormones; D004298:Dopamine