Total synthesis and stereochemistry of (-)-cacospongionolide F.
[reaction: see text] The most recently described member of the cacospongionolide class of marine natural products has been assembled using a diastereochemically divergent total synthesis strategy that independently establishes the complete stereochemistry of cacospongionolide F and provides a new entry toward expansion of this phospholipase A(2) inhibitor chemotype.
Demeke
Damtew
D
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.
Forsyth
Craig J
CJ
D000818:Animals; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism; D011161:Porifera / Q000737:chemistry; D054830:Sesterterpenes; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry*
D007783:Lactones; D054830:Sesterterpenes; D013729:Terpenes; C476500:cacospongionolide F; D010741:Phospholipases A