title: Apoptotic signaling cascades.
abstract: Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged or unnecessary cells, such as those resulting from DNA damage or during development. There are many factors that contribute to this process, each demonstrating specificity of function, regulation, and pathway involvement. The aim of this brief overview is to provide an introduction to a number of these factors as well as the various apoptotic pathways that have been identified.
authors.affiliation: ALviva Biopharmaceuticals Inc., 218-111 Research Drive, S7N 3R2, Saskatoon, Saskatchewan, Canada. paula.ashe@nrc-cnrc.ga.ca
authors.forename: Paula C
authors.initials: PC
authors.lastname: Ashe
authors.forename: Mark D
authors.initials: MD
authors.lastname: Berry
mesh_terms: D000818:Animals; D053318:Apolipoprotein E3; D001057:Apolipoproteins E / Q000502:physiology; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D053222:Fas Ligand Protein; D019254:Genes, bcl-2 / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D053318:Apolipoprotein E3; D001057:Apolipoproteins E; D051017:Apoptosis Regulatory Proteins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha