title: Brief report: carotid intima-media thickness in heavily pretreated HIV-infected patients.
abstract: The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p <.05) but not different from control group 2 IMT values. Positive independent associations of IMT with the total-to-HDL cholesterol ratio and waist circumference existed for cases (p <.05) but not for controls. Case IMT did not correlate with parameters of HIV infection and antiretroviral treatment. This case-control study suggests that lipid disturbances, mainly hypoHDLemia, may be involved in the early atherosclerotic process in HIV-infected patients.
authors.affiliation: Centre de Médecine Préventive Cardiovasculaire and Unité CNRS UMR7131, Hôpital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Chironi
authors.forename: Lelia
authors.initials: L
authors.lastname: Escaut
authors.forename: Jerome
authors.initials: J
authors.lastname: Gariepy
authors.forename: Anne
authors.initials: A
authors.lastname: Cogny
authors.forename: Elina
authors.initials: E
authors.lastname: Teicher
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Monsuez
authors.forename: Jaime
authors.initials: J
authors.lastname: Levenson
authors.forename: Alain
authors.initials: A
authors.lastname: Simon
authors.forename: Daniel
authors.initials: D
authors.lastname: Vittecoq
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001786:Blood Glucose; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D008055:Lipids