title: Evaluation of geometrically optimized single- and double-plane interstitial high dose rate implants with respect to conformality and homogeneity.
abstract: The use of a stepping source in high dose rate brachytherapy supported with dwell-time optimization makes it possible to deviate from the classical dosimetry systems. Dose distributions of single- and double-plane implants were analysed for conformality and homogeneity at idealized target volumes. The Paris system was used for catheter positioning and target volume determination. Geometric optimization and individual dose prescription were applied. Volumetric indices and dose parameters were calculated at optimal active length, which was found to be equal to target volume length. The mean conformality, homogeneity, external volume and overdose volume indices were 0.78, 0.67, 0.22 and 0.13, respectively. The average minimum target and reference doses were 69% and 86%, respectively. Comparisons between the volumetric indices of geometrical optimized and non-optimized implants were also performed, and a significant difference was found regarding any index. The geometrical optimization resulted in superior conformality and slightly inferior homogeneity. At geometrically optimized implants, the active length can be reduced compared to non-optimized implants. Volumetric parameters and dose-volume histogram-based individual dose prescription are recommended for quantitative assessment of interstitial implants.
authors.affiliation: Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary. major@oncol.hu
authors.forename: Tibor
authors.initials: T
authors.lastname: Major
authors.forename: Csaba
authors.initials: C
authors.lastname: Polgár
authors.forename: János
authors.initials: J
authors.lastname: Fodor
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Takácsi-Nagy
authors.forename: László
authors.initials: L
authors.lastname: Mangel
authors.forename: György
authors.initials: G
authors.lastname: Németh
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted