Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.
Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a mouse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL) controlling TMEVD severity in male and female backcross populations derived from susceptible DBA/2J and resistant BALBc/ByJ mice. We report QTL on chromosomes 1, 5, 15, and 16 affecting male mice. In addition, we identified two QTL in female mice located on chromosome 1. Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice.
Butterfield
Russell J
RJ
Department of Veterinary Pathobiology, University of Illinois, Urbana, Illinois 61802, USA.
Roper
Randall J
RJ
Rhein
Dominic M
DM
Melvold
Roger W
RW
Haynes
Lia
L
Ma
Runlin Z
RZ
Doerge
R W
RW
Teuscher
Cory
C
D000818:Animals; D018188:Cardiovirus Infections / Q000235:genetics*; D003711:Demyelinating Diseases / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D020234:Gait Ataxia / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008297:Male; D051379:Mice; D008957:Models, Genetic; D009103:Multiple Sclerosis / Q000235:genetics; D040641:Quantitative Trait Loci; D012727:Sex Characteristics; D017945:Theilovirus