Cationic transfection lipids.
This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.
Liu
Dexi
D
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA. dliu@pitt.edu
Ren
Tan
T
Gao
Xiang
X
D000818:Animals; D002412:Cations; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry / Q000235:genetics*; D014162:Transfection / Q000379:methods*
D002412:Cations; D008055:Lipids