title: Bone morphogenetic protein 7 ex vivo gene therapy.
abstract: Acquired and congenital skeletal defects arise from trauma and developmental abnormalities as well as ablative cancer surgery. Reconstructive surgery to repair the functional limitations and aesthetic concerns caused by these defects can be complex and extensive, and therapeutic restoration of structure and function is often difficult. Currently, autologous bone grafts are the "gold standard" method for surgical repair. Protein therapy, whereby recombinant or naturally sourced bone morphogenetic proteins are surgically implanted in a defect, has recently been approved for limited clinical use. Yet protein therapy and other methods including allografting, alloplastic implants and cell therapy have significant limitations. Recent advances in bone morphogenetic protein 7 ex vivo gene therapy for localized skeletal regeneration address these limitations.
authors.affiliation: Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, 48109-1078, USA. rbruth@umich.edu
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Rutherford
authors.forename: Brian
authors.initials: B
authors.lastname: Nussenbaum
authors.forename: Paul H
authors.initials: PH
authors.lastname: Krebsbach
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000627:therapeutic use; D001861:Bone Regeneration; D005818:Genetic Engineering; D015316:Genetic Therapy; D006801:Humans; D010012:Osteogenesis; D011994:Recombinant Proteins / Q000627:therapeutic use; D016212:Transforming Growth Factor beta; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta