title: [Characterisation of microbial growth and role of the foot tendinous-synovial formation in pathogenesis of diabetic gangrene of the lower extremity].
abstract: The paper is based on the analysis of results of treatment of 74 patients with diabetes mellitus complicated by pyo-necrotic injuries of the foot. In all patients, microbiological procedures were done besides general clinical studies. The material for microbiological assays was the purulent exudation taken from the deeper portions of the wound immediately after lancing the pathological focus. The microbial content was studied separately in fragments of the tendon from its distal (adjacent to the wound) and proximal (every other 6 to 7 cm within the confines of the intact common integument) ends. In the wound, it came up to 6.45 +/- 0.16 lg/ml and 5.2 +/- 0.31 lg/ml (P < 0.05), in the distal end it was 5.93 +/- 0.19 lg/ã and 4.81 +/- 0.24 lg/ã (P < 0.005) for aerobs and anaerobs respectively. In the proximal end of tendons 6-7 cm from the primary pathological focus, aerob gradient was 2.8 +/- 0.19 lg/ã, that for representatives of anaerobic microbes being 1.71 +/- 0.161 lg/ã (P < 0.001). In one third of patients the anaerobic microflora gradient was not found out.
authors.forename: A S
authors.initials: AS
authors.lastname: Islamov
authors.forename: B B
authors.initials: BB
authors.lastname: Zhanabaev
authors.forename: A S
authors.initials: AS
authors.lastname: Bobobekov
mesh_terms: D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001420:Bacteria, Aerobic / Q000187:drug effects / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000302:isolation & purification; D048909:Diabetes Complications; D017719:Diabetic Foot / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D005122:Exudates and Transudates / Q000382:microbiology; D005734:Gangrene / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D013583:Synovial Membrane / Q000382:microbiology*; D013710:Tendons / Q000382:microbiology*; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents