title: Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells.
authors.affiliation: Department of Chemistry, Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92623-9543, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Burk
authors.forename: David F
authors.initials: DF
authors.lastname: Woodward
authors.forename: Achim H P
authors.initials: AH
authors.lastname: Krauss
authors.forename: June
authors.initials: J
authors.lastname: Chen
authors.forename: Charles E
authors.initials: CE
authors.lastname: Protzmann
authors.forename: Linda S
authors.initials: LS
authors.lastname: Williams
authors.forename: Ming F
authors.initials: MF
authors.lastname: Chan
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D002415:Cats; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007498:Iris / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009798:Ocular Hypertension / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D015237:Dinoprost