Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
We describe a superfamily of eukaryotic and prokaryotic proteins (kleisins) that includes ScpA, Scc1, Rec8, and Barren. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family.
Schleiffer
Alexander
A
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria. schleiffer@imp.univie.ac.at
Kaitna
Susanne
S
Maurer-Stroh
Sebastian
S
Glotzer
Michael
M
Nasmyth
Kim
K
Eisenhaber
Frank
F
D000251:Adenosine Triphosphatases / Q000502:physiology; D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins / Q000502:physiology; D029721:Drosophila Proteins; D010450:Endopeptidases / Q000502:physiology*; D005656:Fungal Proteins; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D046912:Multiprotein Complexes; D009687:Nuclear Proteins / Q000737:chemistry; D010750:Phosphoproteins / Q000502:physiology*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D000097722:Cohesins
D000251:Adenosine Triphosphatases; D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D010450:Endopeptidases; D005656:Fungal Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D000097722:Cohesins; C103227:Barr protein, Drosophila; C490529:MCD1 protein, S cerevisiae; C108312:condensin complexes; C540907:psm1 protein, S pombe; C077081:REC8 protein, S pombe; C053088:C5a peptidase