Helper T-cell-regulated B-cell immunity.
Helper T-cell-regulated B-cell responses constitute a major component of the immune response to many pathogens. Spatially and temporally organized cognate intercellular communication within secondary lymphoid organs is the critical regulating event in this complex adaptive response to antigen. Here, we discuss what is known of these molecular exchanges and their cellular consequences in a serial synapsis model of adaptive immunity.
McHeyzer-Williams
Michael
M
Department of Immunology, Duke University Medical Center, Box 3010, Durham, NC 27705, USA. mcheyzer@scripps.edu
McHeyzer-Williams
Louise
L
Panus
Joanne
J
Pogue-Caley
Rebecca
R
Bikah
Gabriel
G
Driver
David
D
Eisenbraun
Michael
M
D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007110:Immunity, Active; D007156:Immunologic Memory; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte