title: [The working classification of antiarrhythmic drugs based on the pathogenetic approach to treatment of cardiac arrhythmias].
abstract: Classification of antiarrhythmic drugs was proposed by E. Williams and updated by D. Harrison in those days when antiarrhythmic activity of activators of the heart's receptors and ionic pumps was studied hardly at all and effect on the sarcolemma's bilipid layer, permiability was not regarded as a method of correction of bioelectrical instability of the myocardium. The authors propose that antiarrhythmic drugs should be considered in four categories: the modulators of ionic channels, the modulators of receptors of the heart, the modulators of ionic pumps, and membrane-protecting agents, with each category subdivided into subclasses and groups of drug preparations.
authors.forename: T N
authors.initials: TN
authors.lastname: Lipnitskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlovskiĭ
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000145:classification* / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors; D016623:Ion Pumps / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism
chemical_list: D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D016623:Ion Pumps; D011941:Receptors, Adrenergic