title: Immunoregulation in the tissues by gammadelta T cells.
abstract: For a T-cell subset to be classified as immunoregulatory, it might reasonably be predicted that in its absence, animals would experience pathological immune dysregulation. Moreover, reconstitution of the subset should restore normal immune regulation. So far, these criteria have been satisfied by only a few of the candidate regulatory T-cell subsets, but among them is the intraepithelial gammadelta T-cell receptor (TCR)+ subset of mouse skin. In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells.
authors.affiliation: Peter Gorer Department of Immunobiology, Guy's, King's and StThomas' Medical School, King's College, London SE1 9RT, UK. adrian.hayday@kcl.ac.uk
authors.forename: Adrian
authors.initials: A
authors.lastname: Hayday
authors.forename: Robert
authors.initials: R
authors.lastname: Tigelaar
mesh_terms: D000818:Animals; D004848:Epithelium / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000172:deficiency / Q000276:immunology*; D012867:Skin / Q000276:immunology; D037182:T-Cell Antigen Receptor Specificity; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta