A comparison of familial and sporadic migraine in a headache clinic population.
We compared the clinical, psychological and pharmacological characteristics of patients with familial migraine and patients with sporadic migraine. Five hundred and thirty consecutive new patients attending our Headache Center over a two-year period were involved in the study. The patients were divided into two groups: A. Familial migraine (famM)--at least one first-degree relative affected; B. Sporadic migraine (spoM)--no first-degree relative affected. Four hundred and twenty-four patients (80%) fulfilled the criteria for famM and 106 (20%) for spoM. The patients with famM showed a significantly (p<0.01) earlier age at onset of the disease. No significant difference in all the remaining features examined was found. Our data suggest that famM and spoM represent a single disease entity.
Rainero
Innocenzo
I
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy. irainero@molinette.piemonte.it
Valfrè
Walter
W
Gentile
Salvatore
S
Lo Giudice
Rossana
R
Ferrero
Margherita
M
Savi
Lidia
L
Pinessi
Lorenzo
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001007:Anxiety / Q000523:psychology; D002648:Child; D003863:Depression / Q000523:psychology; D005260:Female; D005502:Food; D006261:Headache / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D020325:Migraine with Aura / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D020326:Migraine without Aura / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D023303:Oxazolidinones / Q000627:therapeutic use; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D012727:Sex Characteristics; D018170:Sumatriptan / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D014363:Tryptamines
D000894:Anti-Inflammatory Agents, Non-Steroidal; D023303:Oxazolidinones; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C089750:zolmitriptan; D018170:Sumatriptan