title: The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia-induced lethality in mice.
abstract: The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice. The extracts of garlic showed that the antihypoxic effect was dose-dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R-phenylisopropyladenosine (R-PIA), 1.6 mg/kg (R-PIA) as positive controls increased survival time up to 52.5 +/- 2.9 min and 120.5 +/- 6 min, respectively, compared to normal saline (34.73 +/- 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 +/- 4.9 and 68.41 +/- 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia-induced lethality in mice.
authors.affiliation: Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, I.R. Iran. hosseinzadehh@yahoo.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinzadeh
authors.forename: Nargess
authors.initials: N
authors.lastname: Sadati
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005737:Garlic; D002534:Hypoxia, Brain / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010660:Phenylisopropyladenosine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D010660:Phenylisopropyladenosine; D010672:Phenytoin