Radiation hybrid mapping of the canine type I and type IV collagen gene subfamilies.
We are interested in the collagen gene superfamily and its involvement in hereditary diseases of the human and domestic dog. Presented here is radiation hybrid mapping of the type I and type IV collagen gene subfamilies on the most recent version of the canine map. The col1A1 gene was mapped to chromosome 9, col1A2 was mapped to chromosome 14, col4A1 and col4A2 were mapped to chromosome 22 and col4A3 and col4A4 were mapped to chromosome 25. The col4A5 and col4A6 genes, while linked to one another, are not linked in the present version of the canine map but likely are present on the X chromosome. These data provide an insight into the molecular evolution of these subfamilies and increase the number of mapped genes in discrete regions of the canine genome.
Lowe
Jennifer K
JK
Department of Molecular and Cellular Biology, University of Washington, Seattle, WA 98115, USA.
Guyon
Richard
R
Cox
Melissa L
ML
Mitchell
Dianne C
DC
Lonkar
Amy L
AL
Lingaas
Frode
F
André
Catherine
C
Galibert
Francis
F
Ostrander
Elaine A
EA
Murphy
Keith E
KE
D000818:Animals; D024042:Collagen Type I / Q000235:genetics*; D024141:Collagen Type IV / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D021101:Radiation Hybrid Mapping; D014960:X Chromosome
D024042:Collagen Type I; D024141:Collagen Type IV