Cytokine control of memory T-cell development and survival.
Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family--in particular, interleukin-7 (IL-7) and IL-15--act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.
Schluns
Kimberly S
KS
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1319, USA.
Lefrançois
Leo
L
D000818:Animals; D000941:Antigens; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D006801:Humans; D007156:Immunologic Memory; D019409:Interleukin-15 / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D015851:Interleukin-7 / Q000502:physiology; D008213:Lymphocyte Activation; D018448:Models, Immunological; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000502:physiology; D020395:Receptors, Interleukin-7 / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology
D000941:Antigens; D016207:Cytokines; C508024:IL15RA protein, human; D019409:Interleukin-15; D007376:Interleukin-2; D015851:Interleukin-7; D018121:Receptors, Cytokine; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2; D020395:Receptors, Interleukin-7