Immunogenic protein contaminants in pneumococcal vaccines.
Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both. The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays.
Yu
Jigui
J
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Briles
David E
DE
Englund
Janet A
JA
Hollingshead
Susan K
SK
Glezen
W Paul
WP
Nahm
Moon H
MH
D018829:Adhesins, Bacterial; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology; D004340:Drug Contamination; D006801:Humans; D008074:Lipoproteins / Q000276:immunology; D026901:Membrane Transport Proteins; D011008:Pneumococcal Infections / Q000097:blood / Q000276:immunology*; D022242:Pneumococcal Vaccines / Q000276:immunology* / Q000592:standards; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D022242:Pneumococcal Vaccines; C085000:PsaA protein, Streptococcus; C051592:pneumococcal surface protein A