[Effects of salicylate on the capillary permeability of inner ear in guinea pigs].
OBJECTIVE
To further understand the mechanism of salicylate ototoxicity.


METHODS
The capillary permeability of inner ear was compared between the normal group and the salicylate ototoxicity group traced with lanthanum by electron microscopy.


RESULTS
The normal inner/outer spiral vessels of basilar membrane, strial blood vessels had no permeability, whereas the capillaries of endolymphatic sac showed a certain permeability. In salicylate ototoxicity group, the permeability of the capillaries mentioned above increased significantly.


CONCLUSIONS
Salicylate may increase the capillary permeability in inner ear, which may participate in the mechanism of the salicylate ototoxicity.
Zhu
Jin
J
Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing 400038.
Liu
Zhaohua
Z
D000818:Animals; D001489:Basilar Membrane / Q000098:blood supply; D002199:Capillary Permeability / Q000187:drug effects*; D003051:Cochlea / Q000098:blood supply*; D006168:Guinea Pigs; D008297:Male; D012980:Sodium Salicylate / Q000633:toxicity*
D012980:Sodium Salicylate