New acetylenic acids from the marine sponge Stelletta species.
Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.
Zhao
Qingchun
Q
College of Pharmacy, Pusan National University, Busan 609-735, Korea, Korea.
Lee
Seung-Yeon
SY
Hong
Jongki
J
Lee
Chong-O
CO
Im
Kwang Sik
KS
Sim
Chung Ja
CJ
Lee
Dong Seok
DS
Jung
Jee H
JH
D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000480:Alkynes; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; C031203:2-hexadecynoic acid