[Sex factors in effects of aerogenic toxic substances on the duration of hexenal-induced sleep].
Inhalant poisoning with low doses of toxicants during 3 months resulted in slowing the biotransformation of hexenal in male rats, whereas lead acetate and sulphur dioxide were less active. Unlike the male rats, phenol in female ones prolonged hexenal-induced dream. Ammonia did not effect the biotransformation, whereas formaldehyde, lead acetate and sulphur dioxide accelerated it. Sex--linked dimorphism of MOS has been suggested to determine more pronounced hepatotoxicity of the compounds under exploration in male rats.
Inoiatov
F Sh
FSh
Second Medical Institute, Tashkent, Republic of Uzbekistan.
D000280:Administration, Inhalation; D000393:Air Pollutants / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D005260:Female; D006591:Hexobarbital / Q000008:administration & dosage* / Q000378:metabolism; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D012737:Sex Factors; D012890:Sleep / Q000187:drug effects / Q000502:physiology*
D000393:Air Pollutants; D006591:Hexobarbital