title: Will triclosan in toothpaste select for resistant oral streptococci?
abstract: The aims of the study were to determine the in vitro sensitivity of triclosan against viridans streptococci and the impact of triclosan on the normal oral microflora. Nine subjects used a triclosan-containing toothpaste for 2 weeks. Saliva samples were collected on days 0 and 14 and were analyzed quantitatively. The minimum inhibitory concentrations of triclosan and of several antimicrobial agents were determined for the streptococci isolated on days 0 and 14. No major changes occurred in the normal oral microflora during the study period. There were no differences in susceptibility between streptococcal strains collected at days 0 and 14 against triclosan or antimicrobial agents. Short-term use of triclosan has no major impact on normal oral microflora or on streptococcal susceptibility of antimicrobial agents. The effects of long-term use should be evaluated.
authors.affiliation: Department of Microbiology, Pathology and Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sullivan
authors.forename: B
authors.initials: B
authors.lastname: Wretlind
authors.forename: C E
authors.initials: CE
authors.lastname: Nord
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001420:Bacteria, Aerobic / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009910:Oral Hygiene; D012463:Saliva / Q000382:microbiology*; D013291:Streptococcus / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D013295:Streptococcus mutans / Q000187:drug effects / Q000254:growth & development; D013298:Streptococcus sanguis / Q000187:drug effects / Q000254:growth & development; D014100:Toothpastes; D014260:Triclosan / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000891:Anti-Infective Agents, Local; D014100:Toothpastes; D014260:Triclosan