Antitumor activity of flavones isolated from Artemisia argyi.
The flavones 5,6-dihydroxy-7,3',4'-trimethoxyflavone ( 1), 5,6,4'-trihydroxy-7,3'-dimethoxyflavone ( 2), 5-hydroxy-3',4',6,7-tetramethoxyflavone, 5,7,3'-trihydroxy-6,4',5'-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC 50 values of 25 - 200 microg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds 1 and 2 inhibited growth of a colon tumor (SW620) by 44.6 % and 14.6 %, respectively.
Seo
Jeong-Min
JM
Korea Research Institute of Bioscience and Biotechnology, Uen-dong, Yoosung-gu, Taejon, Republic of Korea.
Kang
Hyun-Mi
HM
Son
Kwang-Hee
KH
Kim
Jong Han
JH
Lee
Chang Woo
CW
Kim
Hwan Mook
HM
Chang
Soo-Ik
SI
Kwon
Byoung-Mog
BM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D019306:Artemisia; D002642:Chick Embryo / Q000187:drug effects; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts