title: Androgen-independent prostate cancer: potential role of androgen and ErbB receptor signal transduction crosstalk.
abstract: In prostate cancer (PC), increasing evidence suggests that androgen receptor (AR) signalling is functional under conditions of maximal androgen blockade. PC cells survive and proliferate in the altered hormonal environment possibly by interactions between growth factor-activated pathways and AR signalling. The present review article summarizes the current evidence of this crosstalk and focuses on the interactions among the ErbB receptor network, its downstream pathways, and the AR. The potential role of this crosstalk in the development of androgen independence and in relation to antiandrogen therapy is discussed. Such interactions provide insight into possible complementary or additional strategies in the management of PC.
authors.affiliation: Department of Histopathology, Imperial College, Hammersmith Hospital Campus, London, UK.
authors.forename: Soha Salama
authors.initials: SS
authors.lastname: El Sheikh
authors.forename: Jan
authors.initials: J
authors.lastname: Domin
authors.forename: Paul
authors.initials: P
authors.lastname: Abel
authors.forename: Gordon
authors.initials: G
authors.lastname: Stamp
authors.forename: El-Nasir
authors.initials: el-N
authors.lastname: Lalani
mesh_terms: D000728:Androgens / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D008954:Models, Biological; D018739:Oncogene Proteins v-erbB / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D011471:Prostatic Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000728:Androgens; D018739:Oncogene Proteins v-erbB; D011944:Receptors, Androgen; D019869:Phosphatidylinositol 3-Kinases