title: A first cyclopenta[c]thiophene dimer as a new bivalent potent cytotoxic derivative.
abstract: Application of the bivalent approach to the cyclopenta[c]thiophene series led to a potent cytotoxic dimer.
authors.affiliation: Centre d'Etudes et de Recherche sur le Medicament de Normandie, UFR des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, 1, rue Vaubénard, 14032 Caen cedex, France.
authors.forename: Lan Pham
authors.initials: LP
authors.lastname: Khanh
authors.forename: Patrick
authors.initials: P
authors.lastname: Dallemagne
authors.forename: Henriette
authors.initials: H
authors.lastname: Landelle
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013876:Thiophenes