Yeasts make their mark.
Budding and fission yeast serve as genetic model organisms for the study of the molecular mechanisms of cell polarity in single cells. Similar to other polarized eukaryotic cells, yeast cells have polarity programmes that regulate where they grow and divide. Here, we describe recent advances in defining the proteins that establish cell polarity and the numerous molecular interactions that may link these factors to the actin cytoskeleton. As many of these components are identified, a comprehensive understanding of complex pathways is beginning to emerge.
Chang
Fred
F
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York NY, 10032, USA. fc99@columbia.edu
Peter
Matthias
M
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D003599:Cytoskeleton / Q000235:genetics; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics; D015003:Yeasts / Q000166:cytology / Q000235:genetics / Q000378:metabolism*
D005656:Fungal Proteins