Influence of Myelopeptides on IL-1 and IL-2 Activities.
Myelopeptides are immunoregulatory molecules originally isolated from porcine bone marrow cell culture. The influence of synthetic analogous of these peptides on IL-1 and IL-2 activities was studied. Myelopeptide-1 but not myelopeptide-2 replaced IL-1 activity in a test of costimulation of thymocyte proliferation in the presence of mitogen. Conversely, myelopeptide-2, but not myelopeptide-1, stimulated both production of IL-2 by murine splenocytes and IL-2-dependent proliferation of CTLL-2 cell line. The enhancing effect of myelopeptide-2 on IL-2-associated processes was the most pronounced at the early stages of cell activation. The resting T cells stimulated with suboptimum doses of concanavalin A and activated T cells, expressing low level of IL-2R, were sensitive to myelopeptide-2 action. The possible role of myelopeptides in differentiation of T0 helper into T1 helper and T2 helper is discussed.
Svirshchevskaya
E. V.
EV
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.
Belevskaya
R. G.
RG
Roslavtzeva
T. A.
TA
Sapozhnikov
A. M.
AM
Mikhailova
A. A.
AA