title: Synthesis of aminonicotinonitriles and diaminopyridines through base-catalyzed ring transformation of 2H-pyran-2-ones.
abstract: An efficient and convenient synthesis of 2-amino-6-aryl-4-methylsulfanylnicotinonitriles (2), 2-amino-6-aryl-4-substituted-aminonicotinonitriles (4), and 2-amino-6-aryl-4-substituted-aminopyridines (6) has been delineated and illustrated through base-catalyzed ring transformation of 6-aryl-3-cyano-4-methylsulfanyl/substituted-amino-2H-pyran-2-ones (1, 3, and 5) with cyanamide and ammonium carbonate separately.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India.
authors.forename: Farhanullah
authors.initials: F
authors.lastname: Farhanullah
authors.forename: Nidhi
authors.initials: N
authors.lastname: Agarwal
authors.forename: Atul
authors.initials: A
authors.lastname: Goel
authors.forename: Vishnu Ji
authors.initials: VJ
authors.lastname: Ram