The effect of commonly used drugs on angiogenesis.
BACKGROUND
Within the last decade, there has been much interest in the area of tumor angiogenesis, with the advent of many new anti-angiogenic drugs undergoing testing in cancer clinical Phases II and III. Many of the cancer patients also take multiple medications for a variety of chronic illnesses. Because of possible drug-drug interactions, it is important to investigate the effect that commonly prescribed medications may have on angiogenesis.


METHODS
In this pilot study, we assessed the effect of the following drugs on in vitro angiogenesis: atenolol, diltiazem, enalapril, disopyramide, mexiletine, coumadin, cimetidine and omeprazole.


CONCLUSIONS
We observed that, although some of these drugs at massive doses inhibited endothelial proliferation, they did not affect in vitro angiogenesis at human therapeutic ranges.
Sartippour
Maryam R
MR
University of California, Los Angeles, Department of Surgery, Division of Oncology, Los Angeles, CA 90095, USA.
De Leon
Ernesto
E
Rubio
Rosalio
R
Brooks
Mai N
MN
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002927:Cimetidine / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004206:Disopyramide / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004656:Enalapril / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008801:Mexiletine / Q000494:pharmacology; D009853:Omeprazole / Q000494:pharmacology; D010865:Pilot Projects; D014859:Warfarin / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D008801:Mexiletine; D001262:Atenolol; D014859:Warfarin; D004656:Enalapril; D002927:Cimetidine; D004110:Diltiazem; D004206:Disopyramide; D009853:Omeprazole