[Bioclinical correlations in bony metastases. Results of a prospective study. 60 cases].
Our objective is to compare clinical and biological presentation of patients with bone metastatic disease.


METHODS
We collected prospectively 60 patients (adults and children) with proven bone metastasis. Tumors are mainly breast cancer (25/60) or nasopharyngeal carcinoma (8/60). All 8 children presented all with abdominal neuroblastoma. Bone lesions are lytic in 85% of cases. ALP and LDH seem to be sensitive markers for bone mestatasis with 75% and 80% pathologic rates. The highest rates have been observed in patients with multiple bones lesions (> 8) and painful metastases (more than 7 in the VAS). The median survival was 8 months (3 to 54).


CONCLUSIONS
Even conventional, some biochemical markers as ALP and LDH remain useful in the diagnosis and prognosis in patients with proven bone metastasis.
Belhaj
Raja
R
Institut Salah Azaiz Tunis.
Boussen
Hamouda
H
Ghanem
Abderraouf
A
Essafer
Saloua
S
Harzallah
Latifa
L
Ben Ayed
Farhat
F
Guemira
Fethi
F
D000008:Abdominal Neoplasms / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014416:Tunisia / Q000453:epidemiology
D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase