title: Is classical Hodgkin's disease indeed a single entity?
abstract: We present a retrospective clinicopathological study on the significance of the histologic type of classical Hodgkin's disease (HD) in a cohort of patients from southern Israel. This was performed to critically evaluate the generally accepted view that classical HD is a single clinicopathological entity and the resultant impression that its segregation into four different histologic types remains essential only for the pathologist in his diagnostic endeavor. We confirmed the existence of a uniform response of nodular sclerosis (NS), and mixed cellularity-lymphocyte depletion (MC-LD)-HD to treatment, consideration being given to other classical prognostic factors. We also accept the fact that histological type is not a significant independent factor in terms of survival. Our findings, however, do suggest that NS-HD, on the one hand, and MC-LD-HD, on the other, are distinct biologic entities. Cases of NS differ significantly from those of MC-LD-HD with regard to sex and age distribution, and in the expression of several antigens and gene products, including sialylated-CD15, CD30, LMP1 and the p53 and mdm-2 gene products.
authors.affiliation: Department of Epidemiology, Faculty of Health Sciences and Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Amalia
authors.initials: A
authors.lastname: Levy
authors.forename: Yaron
authors.initials: Y
authors.lastname: Armon
authors.forename: Jacob
authors.initials: J
authors.lastname: Gopas
authors.forename: Samuel
authors.initials: S
authors.lastname: Ariad
authors.forename: Isebrand
authors.initials: I
authors.lastname: Prinsloo
authors.forename: Ofer
authors.initials: O
authors.lastname: Shpilberg
authors.forename: Joseph
authors.initials: J
authors.lastname: Kapelushnik
authors.forename: Martin
authors.initials: M
authors.lastname: Sacks
authors.forename: Daniel
authors.initials: D
authors.lastname: Benharroch
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D012598:Sclerosis / Q000175:diagnosis; D012737:Sex Factors; D013997:Time Factors