Oral bisphosphonate therapy for vitamin D intoxication of the infant.
Vitamin D intoxication in infancy has serious consequences attributable to acute hypercalcemia and subsequent hypercalcuria/nephrocalcinosis. Current treatments of patients with vitamin D intoxication are unsatisfactory and associated with prolonged hypercalcemia. We now report the use of oral alendronate sodium in a 3-month-old infant with vitamin D intoxication. Short-term oral alendronate sodium treatment effectively corrected hypercalcemia/hypercalciuria, decreased the duration of hospitalization, and appears safe in 15 months of observation.
Bereket
Abdullah
A
Department of Pediatrics, Division of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul 81030, Turkey. abereket@e-kolay.net
Erdogan
Tulay
T
D000284:Administration, Oral; D019386:Alendronate / Q000627:therapeutic use*; D001847:Bone Diseases / Q000139:chemically induced / Q000188:drug therapy; D006225:Hand / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced / Q000188:drug therapy; D007049:Iatrogenic Disease / Q000517:prevention & control; D007223:Infant; D008297:Male; D009397:Nephrocalcinosis / Q000139:chemically induced / Q000188:drug therapy; D012598:Sclerosis / Q000139:chemically induced / Q000188:drug therapy; D014545:Urinary Calculi / Q000139:chemically induced / Q000188:drug therapy; D014807:Vitamin D / Q000009:adverse effects*
D014807:Vitamin D; D019386:Alendronate