[Dynamics of changes in the heparin-binding activity of rat brain proteins after fractionated exposure to ionizing radiation of low intensity].
In experiment on white rats it was shown that fractionated exposure to 1 sGy/day during 25 days is followed by the directed change in the total heparin-binding activity of proteins in the rat brain (both in males and in females) with maximum deviation from control by the 7th day after accumulation of a total dose of 25 sGy. The diverse in hemisphere cortex and hippocampus were different from those in brain trunk regions and cerebellum. It is supposed that a thin overturning of the intercellular and "cell-matrix" interactions in CNS modulates compensation and adaptation processes under chronic X-ray irradiation with a small dose of low intensity due to regulation of the free/bound heparansulphate correlation.
Belousova
T V
TV
Dnepropetrovsk National University, Dnepropetrovsk Division of International Centre of Molecular Physiology, National Academy of Science of Ukraine, Dnepropetrovsk, 49050 Ukraine.
Ushakova
G A
GA
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects*; D001933:Brain Stem / Q000378:metabolism / Q000528:radiation effects; D002531:Cerebellum / Q000378:metabolism / Q000528:radiation effects; D002540:Cerebral Cortex / Q000378:metabolism / Q000528:radiation effects; D003627:Data Interpretation, Statistical; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006493:Heparin / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011485:Protein Binding; D011829:Radiation Dosage; D051381:Rats; D013997:Time Factors
D006493:Heparin; D006497:Heparan Sulfate; D009419:Nerve Tissue Proteins