title: Naphthalimides as anti-cancer agents: synthesis and biological activity.
abstract: Naphthalimides are a class of compounds with high antitumor activity upon a variety of murine and human tumor cells. These compounds bind to DNA by intercalation of the chromophore and two of them, mitonafide and amonafide, were used in clinical trials. The therapeutic properties of these lead drugs were improved by designing bisintercalating agents. One of these, elinafide, showed intense in vitro and in vivo activity and is currently being used in clinical trials against solid tumors. In this paper, the history of elinafide is described.
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Facultad de Ciencias Experimentales, Universidad San Pablo-CEU, Montepríncipe. Boadilla del Monte, 28668-Madrid, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Braña
authors.forename: A
authors.initials: A
authors.lastname: Ramos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes