title: Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists.
abstract: The synthesis and structure-activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B(2) receptor antagonists are described. Several members of this series display nanomolar affinity at the B(2) receptor and show activity in an animal model of antinociception.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, Welsh & McKean Roads, PO Box 776, Spring House, PA 19477-0776, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Youngman
authors.forename: John R
authors.initials: JR
authors.lastname: Carson
authors.forename: Jung S
authors.initials: JS
authors.lastname: Lee
authors.forename: Scott L
authors.initials: SL
authors.lastname: Dax
authors.forename: Sui-Po
authors.initials: SP
authors.lastname: Zhang
authors.forename: Ray W
authors.initials: RW
authors.lastname: Colburn
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Stone
authors.forename: Ellen E
authors.initials: EE
authors.lastname: Codd
authors.forename: Michele C
authors.initials: MC
authors.lastname: Jetter
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D065168:Bradykinin Receptor Antagonists; D007202:Indicators and Reagents; D007509:Irritants / Q000037:antagonists & inhibitors; D007616:Kaolin; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D043782:Receptor, Bradykinin B2; D013329:Structure-Activity Relationship
chemical_list: D000473:Alkanes; D000700:Analgesics; D065168:Bradykinin Receptor Antagonists; D007202:Indicators and Reagents; D007509:Irritants; D011758:Pyrroles; D043782:Receptor, Bradykinin B2; D007616:Kaolin