Serotonin depletion enhances the intracerebroventricularly administered MK-801-induced plasma interleukin-6 levels in mice.
To investigate the effect of serotonin depletion on the intracerebroventricularly (i.c.v.) administered MK-801-induced plasma interleukin-6 (IL-6) levels, we pretreated mice with parachlorophenylalanine (PCPA, 300 mg/kg, i.p.) 3 d before an i.c.v. injection of MK-801 (1 microg). The i.c.v. MK-801-induced rise of plasma IL-6 level was markedly enhanced in the PCPA-pretreated mice. However, serotonin depletion by PCPA pretreatment did not affect the i.c.v. MK-801-induced increase in plasma corticosterone level. These results suggest that serotonergic system is involved in the suppressive regulation of MK-801-induced plasma IL-6 level.
Kim
Do-Hoon
DH
Department of Psychiatry, College of Medicine, Hallym University, South Korea.
Jung
Jun-Sub
JS
Moon
Yoo-Sun
YS
Suh
Hong-Won
HW
Song
Dong-Keun
DK
D000818:Animals; D003345:Corticosterone / Q000097:blood; D016291:Dizocilpine Maleate / Q000008:administration & dosage*; D010134:Fenclonine / Q000494:pharmacology; D007276:Injections, Intraventricular; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012701:Serotonin / Q000172:deficiency*
D015850:Interleukin-6; D012701:Serotonin; D016291:Dizocilpine Maleate; D010134:Fenclonine; D003345:Corticosterone