Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents.
A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.
Holla
B Shivarama
BS
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, 574 199, Mangalagangothri, India. hollabs@yahoo.com
Malini
K V
KV
Rao
B Sooryanarayana
BS
Sarojini
B K
BK
Kumari
N Suchetha
NS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002351:Carrageenan; D004121:Dimethyl Sulfoxide; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006097:Granulation Tissue / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D051381:Rats; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D013844:Thiazoles; D002351:Carrageenan; D007052:Ibuprofen; D004121:Dimethyl Sulfoxide