[Gender difference of clinical features in Japanese patients with alcoholic liver cirrhosis].
Gender difference of alcohol intake and laboratory data was investigated in 165 Japanese patients with alcoholic liver cirrhosis. Mean age of first drinking and habitual drinking were higher in female. Duration of drinking was shorter in female. Although cumulative alcohol intake was larger in male, mean daily alcohol intake did not differ in both gender. Moreover, daily alcohol intake adjusted to body weight was significantly larger in female. Body mass index, serum levels of total protein, albumin and cholinesterase were significantly decreased in female. Platelet counts on admission did not differ in both gender. However, it was significantly increased in female after one month abstinence. C reactive protein, ammonia and serum levels of total bilirubin were significantly higher in female as compared to male. In conclusion, female alcoholics seems to progress to liver cirrhosis earlier because of high daily alcohol intake adjusted to body weight, poor nutritional condition and inflammation caused by endotoxin.
Kawashima
Osamu
O
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Ohata
Mitsuru
M
Sakamoto
Kazuhiko
K
Hashimoto
Kenichi
K
Nakajima
Hisato
H
Yamauchi
Masayoshi
M
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000641:Ammonia / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004731:Endotoxins / Q000009:adverse effects; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications; D007564:Japan / Q000453:epidemiology; D008099:Liver / Q000378:metabolism; D008104:Liver Cirrhosis, Alcoholic / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D014176:Protein Biosynthesis; D012737:Sex Factors
D004731:Endotoxins; D000641:Ammonia; D002097:C-Reactive Protein