Arg tyrosine kinase expression in human gastric adenocarcinoma is associated with vessel invasion.
BACKGROUND
Gastric cancer is one of the prevalent cancer types in the Far East region. In order to discover new prognostic and diagnostic biomarkers for gastric cancer progression, we have used degenerated PCR primers designed to amplify all expressed protein tyrosine kinase molecules from human cancer tissues. In previous studies, we have shown the clinical significance of arg tyrosine kinases in a colorectal cancer progression model.


METHODS
We further investigated the protein expression of arg tyrosine kinase by immunohistochemistry and analyzed the clinicopathological association with human cancers.


CONCLUSIONS
Specimens from 79 patients were examined and this demonstrated that the expression of arg kinase showed no statistically significant correlation with the patients' overall survival. However, higher levels of arg kinase immunoreactivity did show a statistically significant association with vessel invasion in gastric cancer tissues examined. This indicates a potential involvement of arg in gastric cancer invasion and progression.
Wu
Chew-Wun
CW
Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Li
Anna F Y
AF
Chi
Chin-Wen
CW
Huang
Cheng-Jien
CJ
Huang
Chen Lung
CL
Lui
Wing-Yiu
WY
Lin
Wen-Chang
WC
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology*; D000368:Aged; D000595:Amino Acid Sequence; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology*
C426236:ARG tyrosine kinase; D011505:Protein-Tyrosine Kinases