title: Piperazine N-substituted naphthyridines, pyridothienopyrimidines and pyridothienotriazines: new antiprotozoals active against Philasterides dicentrarchi.
abstract: New antiprotozoals active against Philasterides dicentrarchi, the causative agent of scuticociliatosis in farmed turbot and Black Sea bass-bream, have been synthesised and tested. The most active compounds posses a piperazine ring, generally N-bonded to the heterocycle, and are the 1,8-naphthyridines, 2f and 5o, the pyridothienopyrimidine (7), and the pyridothienotriazines, 8, 9, 12d, 12f, 12h, 12m and 12k. Pyridothienotriazine (12k) presents the same activity (Lethal Dose, LD=0.8/1.5 mg L(-1)) as the well-known antiparasitics niclosamide and oxyclozanide.
authors.affiliation: Departamento de Qui;mica Fundamental e Industrial, Facultad de Ciencias, Universidad de La Coruña, 15071, La Coruña, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Quintela
authors.forename: Carlos
authors.initials: C
authors.lastname: Peinador
authors.forename: Liliana
authors.initials: L
authors.lastname: González
authors.forename: Raúl
authors.initials: R
authors.lastname: Iglesias
authors.forename: Anabel
authors.initials: A
authors.lastname: Paramá
authors.forename: Francisca
authors.initials: F
authors.lastname: Alvarez
authors.forename: Manuel L
authors.initials: ML
authors.lastname: Sanmartín
authors.forename: Ricardo
authors.initials: R
authors.lastname: Riguera
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001492:Bass / Q000469:parasitology; D016770:Ciliophora Infections / Q000469:parasitology*; D003470:Culture Media; D005393:Fish Diseases / Q000469:parasitology*; D005412:Flatfishes / Q000469:parasitology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D016802:Oligohymenophorea / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D003470:Culture Media; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D009287:Naphthyridines; D011743:Pyrimidines