Two cases of occupational allergic contact dermatitis from a cycloaliphatic epoxy resin in a neat oil: case report.
BACKGROUND
Metal-working fluids contain complex mixtures of chemicals and metal workers constitute a potential risk group for the development of allergic contact dermatitis.


METHODS
Two metal workers developed allergic contact dermatitis on the hands and lower arms from exposure to a neat oil used in metal processing. Patch testing revealed that the relevant contact allergen was a cycloaliphatic epoxy resin, 1,2-cyclohexanedicarboxylic acid, bis(oxiranylmethyl) ester, added to the oil as a stabilizer. None of the patients had positive reactions to the bisphenol A-based epoxy resin in the standard series.


CONCLUSIONS
These cases emphasize that well-known contact allergens may show up from unexpected sources of exposure. Further, it can be a long-lasting, laborious process to detect an occupational contact allergen and cooperation from the patient and the manufacturer of the sensitizing product is essential.
Jensen
Charlotte D
CD
Department of Dermatology, Odense University Hospital, University of Southern Denmark, Odense and National Allergy Research Centre, Gentofte, Denmark. charlotte.devantier.jensen@ouh.fyns-amt.dk
Andersen
Klaus E
KE
D000485:Allergens / Q000633:toxicity*; D001559:Benzhydryl Compounds; D003509:Cyclohexanecarboxylic Acids / Q000633:toxicity*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology*; D004853:Epoxy Resins / Q000737:chemistry / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007219:Industrial Oils / Q000633:toxicity*; D008297:Male; D008669:Metallurgy; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D010328:Patch Tests; D010636:Phenols / Q000633:toxicity; D012306:Risk; D000098826:Bisphenol A Compounds
D000485:Allergens; D001559:Benzhydryl Compounds; D003509:Cyclohexanecarboxylic Acids; D004853:Epoxy Resins; D004988:Ethers, Cyclic; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds