title: Reactions of immune system to physical exercises.
abstract: The great attention to reactions of immune system to the physical exercises in sportsmen is linked to the growth of training volumes, to the increase of competition numbers and to the elevation of morbidity. Immune deficiency may be considered as the detonator of pathological processes among which acute respiratory diseases (ARD) are investigated most completely in sports medicine. Other pathologies require long-term observations, but it is not so simple to do due to the frequent renewal of sports groups. Besides ARD, there are reports about the growth of cases of poliomyelitis, endotoxemia, allergic and autoimmune disorders. Immune reactions in sportsmen are developed at the background of fever, impaired balance of ergotrophic hormone activity and in a number of cases under conditions of systemic endotoxemia. We have described the extreme type of immune deficiency in sportsmen, in which we could not determine different isotypes of Ig. The phenomenon of Ig disappearance is reproduced under the experimental conditions that opened the way to study its mechanisms. Physical exercises decrease function of immunocompetent cells, their antiviral resistance, antigen presentation and expression of class II MHC molecules. With the involvement of macrophages hyperproduction of IL-6 is developed in muscle tissues. After physical exercises other cytokines also change the state of immunity. Also, neuropeptides getting in touch the links between endocrine and immune systems may make a contribution to immunosuppression. The immunosuppression may be prevented by use of special carbohydrate diets and by administration of complexed preparations. The prophylaxis is capable to control the morbidity, profoundly to increase the training volumes and to enhance the labor efficiency.
authors.affiliation: Center Immunoprophylaxis, Russian Academy of Natural Sciences, Moscow, Russia.
authors.forename: Boris B
authors.initials: BB
authors.lastname: Pershin
authors.forename: Anatoly B
authors.initials: AB
authors.lastname: Geliev
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Tolstov
authors.forename: Leonid V
authors.initials: LV
authors.lastname: Kovalchuk
authors.forename: Vladimir Ya
authors.initials: VY
authors.lastname: Medvedev
mesh_terms: D017074:Common Variable Immunodeficiency / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D016207:Cytokines / Q000276:immunology; D004032:Diet; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000502:physiology*; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D009479:Neuropeptides / Q000276:immunology; D012137:Respiratory System / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D014801:Vitamin A / Q000378:metabolism
chemical_list: D016207:Cytokines; D007136:Immunoglobulins; D009479:Neuropeptides; D014801:Vitamin A