[Matrix metalloproteinases MMP-2 and MMP-9 of wound and burn exudates and their effect on extracellular matrix proteins].
The dynamics of matrix metalloproteinases (MMP), as well as of fibronectin concentration in wound and burn fluids was traced. The wound fluid proteolytic activity was studied by gelatin zymography method. The data on degradation of fibronectin and various laminin isoforms by wound fluid proteases show that laminin-1, laminin-2/4 and fibronectin were degraded by wound fluid into small fragments. Remodelling of extracellular matrix proteins occurs. Dynamics of MMP-2 and MMP-9 content in wound or burn fluids as well as that of adhesive protein fibronectin content could be used as a base for development of method of controlling the extracellular matrix remodelling process.
Voronkina
I V
IV
Institute of Cytology RAS, St. Petersburg.voron@mail.cytspb.rssi.ru
Kokorin
K V
KV
Chulikov
O V
OV
Paramonov
B A
BA
Blinova
M I
MI
Pinaev
G P
GP
D002056:Burns / Q000201:enzymology*; D002448:Cell Adhesion / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis* / Q000502:physiology; D005122:Exudates and Transudates / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D005353:Fibronectins / Q000096:biosynthesis / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000096:biosynthesis / Q000502:physiology; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism / Q000502:physiology; D020782:Matrix Metalloproteinases / Q000378:metabolism* / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000201:enzymology*
D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007797:Laminin; D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9