title: Genetic mapping of variation in spatial learning in the mouse.
abstract: Inbred strains of mice are known to differ in their performance in the Morris water maze task, a test of spatial discrimination and place navigation in rodents, but the genetic basis of individual variation in spatial learning is unknown. We have mapped genetic effects that contribute to the difference between two strains, DBA/2 and C57BL6/J, using an F2 intercross and methods to detect quantitative trait loci (QTL). We found two QTL, one on chromosome 4 and one on chromosome 12, that influence behavior in the probe trial of the water maze (genome-wide significance p = 0.017 and 0.015, respectively). By including tests of avoidance conditioning and behavior in a novel environment, we show that the QTL on chromosomes 4 and 12 specifically influence variation in spatial learning. QTL that influence differences in fearful behavior (on chromosomes 1, 3, 7, 15, and 19) operate while mice are trained in the water maze apparatus.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, United Kingdom.
authors.forename: Daniela
authors.initials: D
authors.lastname: Steinberger
authors.forename: David S
authors.initials: DS
authors.lastname: Reynolds
authors.forename: Pushpindar
authors.initials: P
authors.lastname: Ferris
authors.forename: Rachael
authors.initials: R
authors.lastname: Lincoln
authors.forename: Susmita
authors.initials: S
authors.lastname: Datta
authors.forename: Joanna
authors.initials: J
authors.lastname: Stanley
authors.forename: Andrea
authors.initials: A
authors.lastname: Paterson
authors.forename: Gerard R
authors.initials: GR
authors.lastname: Dawson
authors.forename: Jonathan
authors.initials: J
authors.lastname: Flint
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics; D003213:Conditioning, Psychological; D003433:Crosses, Genetic; D004597:Electroshock; D005239:Fear / Q000502:physiology; D014644:Genetic Variation / Q000235:genetics / Q000502:physiology*; D008126:Lod Score; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D015999:Multivariate Analysis; D040641:Quantitative Trait Loci / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics; D013037:Spatial Behavior / Q000502:physiology*; D013045:Species Specificity