title: Epsilon-amino caproic acid additive decreases fibrin bandage performance in a swine arterial bleeding model.
abstract: epsilon -Amino caproic acid (EACA), a lysine analog that inhibits the activity of plasmin, was added to Nycomed (TC-S) fibrin bandages, and the bandages were tested for hemostatic efficacy in a swine femoral artery bleeding model. The blood loss using the bandage with EACA (TC-S+EACA; 728.8+/-132 g, n=5) was much greater as compared to the TC-S bandage alone (TC-S; 237.8+/-47.9 g, n=6, p=.02). The time to "cessation of bleeding" (T(b)) was also increased for animals treated with TC-S+EACA bandages compared to the TC-S controls (33.6+/-10.8 min vs. 9.2+/-2.2 min; p=.05). Although plasma fibrinogen concentration decreased in animals treated with the TC-S+EACA bandage, activated partial thromboplastin times (aPTT) and thrombin times (TT) were decreased. Animals treated with the TC-S control bandage exhibited no changes in fibrinogen, aPTT or TT. Prothrombin times (PT) were unchanged in either group. In conclusion, addition of EACA to the Nycomed product decreased fibrin bandage efficiency.
authors.affiliation: Department of Blood Research, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA. stephen.rothwell@na.amedd.army.mil
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Rothwell
authors.forename: James M
authors.initials: JM
authors.lastname: Fudge
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Reid
authors.forename: Chitra
authors.initials: C
authors.lastname: Krishnamurti
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000293:injuries; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000737:chemistry* / Q000592:standards; D006470:Hemorrhage / Q000517:prevention & control / Q000628:therapy*; D006487:Hemostasis / Q000187:drug effects; D006489:Hemostatic Techniques / Q000592:standards*; D006490:Hemostatics / Q000494:pharmacology; D008297:Male; D009779:Occlusive Dressings / Q000592:standards*; D013552:Swine; D014945:Wound Healing / Q000187:drug effects
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D015119:Aminocaproic Acid