The combined contraceptive ring NuvaRing and spermicide co-medication.
The effects of nonoxynol-9 on etonogestrel and ethinylestradiol release and absorption from NuvaRing were studied in 12 subjects for two cycles: one control and one interaction cycle (nonoxynol-9 was administered on day 8). Nonoxynol-9 had no effect on release or absorption and, consequently, serum levels. Therefore, nonoxynol-9 did not compromise the contraceptive efficacy of NuvaRing.
Haring
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Kendle Clinical Pharmacology Unit, Utrecht, The Netherlands.
Mulders
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TM
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D003271:Contraceptive Agents, Female / Q000493:pharmacokinetics*; D003274:Contraceptive Devices, Female; D018592:Cross-Over Studies; D017135:Desogestrel; D004347:Drug Interactions; D045166:Estradiol Congeners / Q000493:pharmacokinetics*; D004997:Ethinyl Estradiol / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D017137:Nonoxynol / Q000494:pharmacology*; D013089:Spermatocidal Agents / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000097:blood / Q000493:pharmacokinetics*
D003271:Contraceptive Agents, Female; D045166:Estradiol Congeners; D013089:Spermatocidal Agents; D014753:Vinyl Compounds; D017137:Nonoxynol; C044815:etonogestrel; D004997:Ethinyl Estradiol; D017135:Desogestrel