Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells.
Burk
Robert M
RM
Department of Chemistry, Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92623-9543, USA.
Woodward
David F
DF
Krauss
Achim H P
AH
Chen
June
J
Protzmann
Charles E
CE
Williams
Linda S
LS
Chan
Ming F
MF
D016475:3T3 Cells; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D002415:Cats; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007498:Iris / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009798:Ocular Hypertension / Q000188:drug therapy*
D000959:Antihypertensive Agents; D015237:Dinoprost