[Ability of cipramil to correct conditioned passive avoidance in ovariectomized female rats].
The ability of cypramil, a selective inhibitor of serotonin re-uptake, to modify the cognitive performance was studied in ovariectomized female rats with passive avoidance paradigm and in the open-field test. It was found that cypramil in combination with estradiol restored the formation and retention of the passive avoidance performance. In addition, cypramil improved the emotional component of behavior in the open-field test.
Fedotova
Iu O
IuO
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. akademika Pavlova Str, 12, St. Petersburg, 197376 Russia.
Sapronov
N S
NS
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D015283:Citalopram / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D010052:Ovariectomy; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D015283:Citalopram; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D007986:Luteinizing Hormone; D017367:Selective Serotonin Reuptake Inhibitors