Emergence of ciprofloxacin-resistant pseudomonas in pediatric otitis media.
OBJECTIVE
The widespread use of fluoroquinolone otic drops has resulted in the emergence and subsequent increase of fluoroquinolone resistance, at rates greater than anticipated. To evaluate the patients with recurrent otorrhea that were unresponsive to topical ciprofloxacin.


METHODS
Seventeen pediatric patients who were treated with refractory otorrhea between 2000 and 2001 were reviewed retrospectively.


RESULTS
All patients had ciprofloxacin-resistant pseudomonas on culture and sensitivity test. Ciprofloxacin-resistant pseudomonas from these patients were multidrug resistant. Imipenem was the most sensitive antibiotic agent, followed by amikacin. Most patients were treated with intramuscular amikacin and two patients were treated with intravenous imipenem.


CONCLUSIONS
In our series, resistance to cirpfloxacin in patients with otitis media is increasing recently. Culture and antibiotic sensitivity test may help guide management. Continuous surveillance is necessary to monitor antibiotic resistance and to guide antibacterial therapy.
Jang
Chul Ho
CH
Department of Otolaryngology, Wonkwang Medical School, Iksan 570-711, Republic of Korea. chul@wonkwang.ac.kr
Park
See Young
SY
D000293:Adolescent; D000583:Amikacin / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology / Q000627:therapeutic use; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D015378:Imipenem; D000583:Amikacin