Life extension properties of superoxide dismutase mimics arise from "calorie restriction".
Manganese-salen superoxide dismutase mimics interfere with the mitochondrial electron transport chain by acting as antimetabolites and thus effect "calorie restriction," leading to extended lifespan.
Naughton
Declan Patrick
DP
School of Pharmacy and Biomolecular Science, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom. d.p.naughton@bton.ac.uk
Fisher
Anna E
AE
D000818:Animals; D000963:Antimetabolites / Q000737:chemistry / Q000494:pharmacology*; D031204:Caloric Restriction; D004579:Electron Transport; D005029:Ethylenediamines / Q000737:chemistry / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D018716:Molecular Mimicry; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000737:chemistry*
D000963:Antimetabolites; D005029:Ethylenediamines; D009942:Organometallic Compounds; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D013482:Superoxide Dismutase