INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia.
Recently, much interest have been focused on the role of INI-1, a partner gene of transfusion protein All-1 for leukemogenesis of acute leukemia cases. We found the presence of a mutation at codon 152 in INI-1 that resulted in a conservative amino acid change in cDNA and genomic DNA from an AML patient. We also found the known polymorphic nucleotide change at the third letter of codon 299 in exon 7 of INI-1 in 3 of 31 ALL cases and in 4 of 30 AML cases. In conclusion, INI-1, a partner gene for ALL-1, is considered to be highly conserved in acute leukemia cases.
Mimori
Koshi
K
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874-0838, Japan.
Inoue
Hiroshi
H
Ishii
Hideshi
H
Mori
Masaki
M
D002868:Chromosomal Proteins, Non-Histone; D003062:Codon; D017124:Conserved Sequence / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D018076:DNA, Complementary; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D000071796:SMARCB1 Protein; D014157:Transcription Factors; D014407:Tumor Cells, Cultured; D016335:Zinc Fingers
D002868:Chromosomal Proteins, Non-Histone; D003062:Codon; D017931:DNA Primers; D018076:DNA, Complementary; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase