title: Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?
authors.forename: Adrián V
authors.initials: AV
authors.lastname: Hernández
authors.forename: Ewout W
authors.initials: EW
authors.lastname: Steyerberg
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D018579:Patient Selection; D018401:Sample Size