Melanoma metastatic to central neurocytoma: a novel case of tumor-to-tumor metastasis.
We report a case of a 43-year-old man with known metastatic melanoma and two intracranial tumors, one of which was resected and confirmed to be melanoma. At autopsy, the second lesion was found to be a central neurocytoma harboring metastatic melanoma. To our knowledge, this represents the first reported case of tumor-to-tumor metastasis to a central neurocytoma. The most common pattern of tumor-to-tumor metastasis for intracranial neoplasms, in which an aggressive high-grade malignancy serves as the source tumor and a more indolent neoplasm serves as the recipient tumor, is affirmed by the present novel example.
Brown
Heather M
HM
Department of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
McCutcheon
Ian E
IE
Leeds
Norman E
NE
Schomer
Donald S
DS
Luna
Mario A
MA
Fuller
Gregory N
GN
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000556:secondary*; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000556:secondary*; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis; D018306:Neurocytoma / Q000175:diagnosis*; D012688:Septum Pellucidum / Q000473:pathology