The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia-induced lethality in mice.
The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice. The extracts of garlic showed that the antihypoxic effect was dose-dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R-phenylisopropyladenosine (R-PIA), 1.6 mg/kg (R-PIA) as positive controls increased survival time up to 52.5 +/- 2.9 min and 120.5 +/- 6 min, respectively, compared to normal saline (34.73 +/- 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 +/- 4.9 and 68.41 +/- 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia-induced lethality in mice.
Hosseinzadeh
Hossein
H
Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, I.R. Iran. hosseinzadehh@yahoo.com
Sadati
Nargess
N
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005737:Garlic; D002534:Hypoxia, Brain / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010660:Phenylisopropyladenosine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D018696:Neuroprotective Agents; D010936:Plant Extracts; D010660:Phenylisopropyladenosine; D010672:Phenytoin