title: Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.
abstract: The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.
authors.affiliation: Neurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA.
authors.forename: Shirley X
authors.initials: SX
authors.lastname: Guo-Ross
authors.forename: Katherine H
authors.initials: KH
authors.lastname: Jones
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Shetty
authors.forename: Wilkie A
authors.initials: WA
authors.lastname: Wilson
authors.forename: H Scott
authors.initials: HS
authors.lastname: Swartzwelder
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002794:Choline / Q000494:pharmacology*; D002796:Choline Deficiency / Q000196:embryology / Q000378:metabolism; D004032:Diet; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018697:Nootropic Agents; D016291:Dizocilpine Maleate; D002794:Choline