title: Severe chronic sensory-motor polyneuropathy: coexistence of 3 unrelated etiologies in a type 1 diabetic patient. A case report and review of the literature.
abstract: We present the case of a 58-year-old man, who has suffered from type 1 diabetes mellitus since he was young. He had monoclonal IgM kappa gammopathy of undetermined significance and high anti-MAG antibody titer. He developed a polyneuropathic picture with the clinical and laboratory features of chronic inflammatory demyelinating polyneuropathy within the span of approximately 2 years. He benefited from IV administration of high doses of immunoglobulins. Investigation of all parameters, but particularly of the clinical phenotype, can lead to a better definition of the polyneuropathic picture, especially for therapeutic and prognostic purposes.
authors.affiliation: Department of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy. Nereo.Bresolin@Unimi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Micco
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nobile-Orazio
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Baron
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Conti
authors.forename: Laura
authors.initials: L
authors.lastname: Napoli
authors.forename: Massimo
authors.initials: M
authors.lastname: Serafini
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Scarlato
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
mesh_terms: D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000473:pathology; D003929:Diabetic Neuropathies / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000209:etiology* / Q000473:pathology