The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria.
Malaria is a leading cause of morbidity and mortality in developing countries. Selection of mutant Plasmodium falciparum malaria strains under drug pressure has led to the development of drug resistance. There is a pressing need for effective, safe, practicable drug combinations that hve lower selection pressure. A review of the mein drug combinations, which are recently registered or are still under development, was undertaken, with special attention to the atovaquone-proguanil and artemether-lumefantrine combination.
Danis
Martin
M
Service de Parasitologie-Mycologie and Unité INSERM 511, Centre Hospitalier Universitaire Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Paris 6, 47 bd de l'Hôpital, 75651 Paris cedex 13, France.
Bricaire
François
F
D000818:Animals; D000962:Antimalarials / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins / Q000008:administration & dosage / Q000627:therapeutic use; D053626:Atovaquone; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use; D005449:Fluorenes / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy*; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use; D002727:Proguanil / Q000008:administration & dosage / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D009285:Naphthoquinones; D012717:Sesquiterpenes; D000077549:Artemether; D000078102:Lumefantrine; D002727:Proguanil; D053626:Atovaquone