title: Immunogenic protein contaminants in pneumococcal vaccines.
abstract: Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both. The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: Jigui
authors.initials: J
authors.lastname: Yu
authors.forename: David E
authors.initials: DE
authors.lastname: Briles
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
authors.forename: Susan K
authors.initials: SK
authors.lastname: Hollingshead
authors.forename: W Paul
authors.initials: WP
authors.lastname: Glezen
authors.forename: Moon H
authors.initials: MH
authors.lastname: Nahm
mesh_terms: D018829:Adhesins, Bacterial; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology; D004340:Drug Contamination; D006801:Humans; D008074:Lipoproteins / Q000276:immunology; D026901:Membrane Transport Proteins; D011008:Pneumococcal Infections / Q000097:blood / Q000276:immunology*; D022242:Pneumococcal Vaccines / Q000276:immunology* / Q000592:standards; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D022242:Pneumococcal Vaccines; C085000:PsaA protein, Streptococcus; C051592:pneumococcal surface protein A