title: Semianalytical thermal model for subablative laser heating of homogeneous nonperfused biological tissue: application to laser thermokeratoplasty.
abstract: We present a semianalytical technique to calculate the temperature in homogeneous nonperfused tissue during subablative laser heating. Analytical expressions of the temperature distribution in time and space are provided for collimated beams with Gaussian and top-hat intensity distributions perpendicularly incident on a finite tissue slab. The temperature distribution produced with a collimated Gaussian beam is the triple sum of the product of four functions of separate variables. The semianalytical technique can be used to rapidly calculate the temperature in laser-irradiated tissue at any point in time and space. The model was used to estimate the corneal temperature during pulsed holmium:YAG laser thermokeratoplasty with various boundary conditions at the anterior and posterior corneal surface. The model demonstrates that the corneal temperature during laser thermokeratoplasty (LTK) with a pulsed Ho:YAG laser may be sufficient to induce superficial vaporization of epithelial cells and local thermal damage to the endothelium. The calculations show that convection at the anterior corneal surface does not have a significant effect on the corneal temperature distribution, but that a better knowledge of the cooling effect of the aqueous is required to better estimate the corneal temperature distribution during LTK.
authors.affiliation: University of Miami, Department of Biomedical Engineering, Coral Gables, Florida 33124, USA.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Manns
authors.forename: David
authors.initials: D
authors.lastname: Borja
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Parel
authors.forename: William
authors.initials: W
authors.lastname: Smiddy
authors.forename: William
authors.initials: W
authors.lastname: Culbertson
mesh_terms: D003198:Computer Simulation; D003315:Cornea / Q000098:blood supply / Q000502:physiology / Q000528:radiation effects* / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D053685:Laser Therapy; D054018:Lasers, Excimer; D008954:Models, Biological; D018903:Photorefractive Keratectomy / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013814:Thermal Conductivity; D016896:Treatment Outcome