Long-term benzimidazole treatment of alveolar echinococcosis with hematogenic subcutaneous and bone dissemination.
We report a case of advanced alveolar echinococcosis (AE) that presented like a malignant tumor. It was diagnosed histologically from a subcutaneous nodule with skin inflammation on the right leg. Additionally, the patient showed bone metastases in the lower thoracic spine and the left third toe. This is the first case with proven hematogenic spread of AE to a subcutaneous site. The patient was treated with albendazole and remained stable for 6 years. When progression of AE occurred the therapy was changed to mebendazole, resulting in a stable condition for further 4 years.
Scheuring
Urban J
UJ
Department of Hematology, Oncology, Infectious Diseases and Rheumatology, J. W. Goethe University Hospital, Theodor Stern Kai 7, 60596 Frankfurt, Germany. scheuring@em.uni-frankfurt.de
Seitz
Hanns Martin
HM
Wellmann
Axel
A
Hartlapp
Joachim H
JH
Tappe
Dennis
D
Brehm
Klaus
K
Spengler
Ulrich
U
Sauerbruch
Tilmann
T
Rockstroh
Jürgen K
JK
D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use; D000923:Anticestodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D001850:Bone Diseases, Infectious / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis; D018512:Parasitemia / Q000188:drug therapy; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology
D000923:Anticestodal Agents; D001562:Benzimidazoles; D008463:Mebendazole; D015766:Albendazole