Radio-tympano-sinu-orthesis with 186Re-colloid: a new treatment modality for chronic otitis media and paranasal mucositis.
This preliminary treatment trial was performed to evaluate the safety and clinical efficacy of intracavitary therapy with (186)Re-colloid in patients with recurrent otitis media and paranasal sinusitis, resistant to pharmacotherapy and surgical treatment.


METHODS
Thirty-nine applications of 5-35 MBq (186)Re-colloid into the tympanon and the paranasal sinuses were performed in 6 patients. Biodistribution and biokinetics were studied by gamma-camera imaging. Clinical success was documented 6-20 mo after therapy by each patient's self-evaluation and by rhinootologic follow-up, using a 4-step score.


RESULTS
No harmful side effects were seen. There was good-to-excellent clinical improvement with a score of +1.44 +/- 0.5 by each patient's self-evaluation and by physicians scoring of +0.81 +/- 0.9 with only negligible extracranial tracer deposition.


CONCLUSIONS
This novel treatment option using intracavitary application of (186)Re-colloid in chronic otitis media and sinusitis is safe and effective. The term "radio-tympano-sinu-orthesis" might be proposed analogously to the well-known radiosynoviorthesis.
Kampen
Willm U
WU
Clinic of Nuclear Medicine, Christian-Albrechts-University, Arnold-Heller-Strasse 9, D-24105 Kiel, Germany. ukampen@nuc-med.uni-kiel.de
Godbersen
Godber S
GS
Czech
Norbert
N
Besch
Otto F
OF
Brenner
Winfried
W
Henze
Eberhard
E
D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002908:Chronic Disease; D003102:Colloids; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000378:metabolism / Q000532:radiotherapy*; D010865:Pilot Projects; D011868:Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D012211:Rhenium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012852:Sinusitis / Q000378:metabolism / Q000532:radiotherapy*; D016896:Treatment Outcome; D014915:Whole-Body Counting
D003102:Colloids; D011868:Radioisotopes; D012211:Rhenium