Granulocyte colony-stimulating factor and its receptor in normal hematopoietic cell development and myeloid disease.
Hematopoiesis, the process of blood cell formation, is orchestrated by cytokines and growth factors that stimulate the expansion of different progenitor cell subsets and regulate their survival and differentiation into mature blood cells. Granulocyte colony-stimulating factor (G-CSF) is the major hematopoietic growth factor involved in the control of neutrophil development. G-CSF is now applied on a routine basis in the clinic for treatment of congenital and acquired neutropenias. G-CSF activates a receptor of the hematopoietin receptor superfamily, the G-CSF receptor (G-CSF-R), which subsequently triggers multiple signaling mechanisms. Here we review how these mechanisms contribute to the specific responses of hematopoietic cells to G-CSF and how perturbations in the function of the G-CSF-R are implicated in various types of myeloid disease.
van de Geijn
G J M
GJ
Department of Hematology, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
Aarts
L H J
LH
Erkeland
S J
SJ
Prasher
J M
JM
Touw
I P
IP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004705:Endocytosis; D005246:Feedback; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D006402:Hematologic Diseases / Q000209:etiology*; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins; D015398:Signal Transduction
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D004247:DNA