Prevention of progression of interstitial lung lesions by early combination therapy with corticosteroids and cyclosporine/cyclophosphamide in two patients with amyopathic dermatomyositis.
Two patients with amyopathic dermatomyositis complicated by interstitial lung lesions were effectively treated with a combination of corticosteroids and cyclosporine and/or cyclophosphamide. A 48-year-old female patient was treated with pulse methylprednisolone and cyclosporine 2 months after onset of dermal symptoms. A 45-year-old male patient was treated with oral prednisolone and pulse cyclophosphamide 2 1/2 months after onset of dermal symptoms. Early evaluation of interstitial lung lesions and early extensive therapy may improve prognosis of interstitial lung lesions in patients with amyopathic dermatomyositis.
Sugisaki
Kota
K
Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama.
Takeda
Isao
I
Iwadate
Haruyo
H
Kanno
Takashi
T
Nishimaki
Tomoe
T
Kasukawa
Reiji
R
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D016572:Cyclosporine; D003520:Cyclophosphamide