title: [The role of copper in tumor angiogenesis--clinical implications].
abstract: This review concerns a brief introduction into the basics of tumor blood vessels development as well as the regulatory mechanisms of this process. The role of copper ions in tumor angiogenesis is discussed. The new antiangiogenic therapies based on a reduction of copper level in tumor microenvironment are reviewed.
authors.affiliation: Zakład Immunologii Nowotworów Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda, Wrocławiu. nasula@wp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Nasulewicz
authors.forename: Adam
authors.initials: A
authors.lastname: Opolski
mesh_terms: D000818:Animals; D002216:Captopril / Q000008:administration & dosage; D003300:Copper / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010084:Oxidation-Reduction; D014266:Trientine / Q000008:administration & dosage; D015032:Zinc / Q000378:metabolism
chemical_list: D003300:Copper; D002216:Captopril; D015032:Zinc; D014266:Trientine