Antikeratin antibodies in sera of patients with connective tissue disease and liver disease.
Sera from 93 patients with connective tissue disease, 36 rheumatoid arthritis, 41 systemic lupus erythematosus, 12 polymyositis/dermatomyositis and 4 systemic sclerosis and sera from 12 patients with liver disease, along with sera of 10 healthy subjects, were tested for antikeratin antibodies using enzyme-linked immunosorbent assay in which the wells were coated with human epidermal keratin. Values above the mean+SD of the 10 healthy subjects were found in 8.3% of rheumatoid arthritis, 29.3% of systemic lupus erythematosus, 33.3% of polymyositis/dermatomyositis, 50% of systemic sclerosis, 16.7% of liver disease patients, and 20% of healthy subjects. The results indicated a character of naturally occurring antibody of antikeratin antibodies in human sera.
Takeda
Isao
I
Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama, Japan.
Iwadate
Haruyo
H
Sugisaki
Kota
K
Kanno
Takashi
T
Shinzawa
Jotaro
J
Kasukawa
Reiji
R
D000906:Antibodies / Q000097:blood*; D003240:Connective Tissue Diseases / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007633:Keratins / Q000276:immunology*; D008107:Liver Diseases / Q000276:immunology*
D000906:Antibodies; D007633:Keratins