Desensitisation of adrenomedullin and CGRP receptors.
Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level. In this article, we discuss the few studies that have been presented on the desensitisation of AM receptors and also present novel data on the desensitisation of endogenous AM receptors in Rat-2 fibroblasts.
Hay
Debbie L
DL
Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK. dl.hay@auckland.ac.nz
Poyner
David R
DR
Smith
David M
DM
D053607:Adrenomedullin; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D054768:G-Protein-Coupled Receptor Kinases; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology; D010455:Peptides / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D051381:Rats; D058261:Receptor Activity-Modifying Proteins; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism* / Q000502:physiology; D018000:Receptors, Peptide / Q000378:metabolism* / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010455:Peptides; D058261:Receptor Activity-Modifying Proteins; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D053607:Adrenomedullin; D000242:Cyclic AMP; D017346:Protein Serine-Threonine Kinases; D054768:G-Protein-Coupled Receptor Kinases; C089176:G-protein-coupled receptor kinase 6