Association between adiponectin and mediators of inflammation in obese women.
Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = -0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.
Engeli
Stefan
S
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, Germany. engeli@fvk.charite-buch.de
Feldpausch
Mareike
M
Gorzelniak
Kerstin
K
Hartwig
Frauke
F
Heintze
Ute
U
Janke
Jürgen
J
Möhlig
Matthias
M
Pfeiffer
Andreas F H
AF
Luft
Friedrich C
FC
Sharma
Arya M
AM
D052242:Adiponectin; D000273:Adipose Tissue / Q000737:chemistry; D001794:Blood Pressure; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D015870:Gene Expression; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D017698:Postmenopause; D011506:Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D052242:Adiponectin; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; D008055:Lipids; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein