High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux.
BACKGROUND
Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan.


METHODS
Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed.


RESULTS
The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps.
Chuanchuen
Rungtip
R
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, USA.
Karkhoff-Schweizer
RoxAnn R
RR
Schweizer
Herbert P
HP
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012680:Sensitivity and Specificity; D014260:Triclosan / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D003470:Culture Media; D014260:Triclosan