title: Notch signaling: endocytosis makes delta signal better.
abstract: Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
authors.affiliation: CNRS UMR 8542, Département de Biologie, Ecole Normale Supérieure, 46 rue d'Ulm, 75230, Paris cedex, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Le Borgne
authors.forename: François
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D014981:Xenopus; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D029961:Zebrafish Proteins; C064045:delta protein; D044767:Ubiquitin-Protein Ligases; C471932:mib1 protein, zebrafish