[The role of copper in tumor angiogenesis--clinical implications].
This review concerns a brief introduction into the basics of tumor blood vessels development as well as the regulatory mechanisms of this process. The role of copper ions in tumor angiogenesis is discussed. The new antiangiogenic therapies based on a reduction of copper level in tumor microenvironment are reviewed.
Nasulewicz
Anna
A
Zakład Immunologii Nowotworów Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda, Wrocławiu. nasula@wp.pl
Opolski
Adam
A
D000818:Animals; D002216:Captopril / Q000008:administration & dosage; D003300:Copper / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010084:Oxidation-Reduction; D014266:Trientine / Q000008:administration & dosage; D015032:Zinc / Q000378:metabolism
D003300:Copper; D002216:Captopril; D015032:Zinc; D014266:Trientine