[Evaluation of treatment efficacy of non-healing wounds and trophic ulcers of the lower extremities].
A method of objective evaluation of treatment efficacy and outcomes prognosis of plastic surgeries in patients with non-healing defects has been developed. The method is based on dynamic study of free serotonin and histamine concentration in blood obtained from the elbow vein and vein of the affected limb. Level of these biogenic amines depends on disease severity and area of affection. In 32 patients phonophoresis with hydrocortisone was used that had positive influence on healing of tissue defect. This procedure is accompanied by reduction of free serotonin and histamine concentration. If their concentrations do not decrease ulcers heal very slowly. Study of biogenic amines concentration before and during treatment permitted the authors to identify favorable and unfavorable group of patients.
Izmaĭlov
S G
SG
Izmaĭlov
G A
GA
Vidmanov
G I
GI
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017719:Diabetic Foot / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015612:Phonophoresis / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods*; D012701:Serotonin / Q000097:blood; D016896:Treatment Outcome; D014945:Wound Healing
D000893:Anti-Inflammatory Agents; D012701:Serotonin; D006632:Histamine; D006854:Hydrocortisone