[Effect of adaptation to cold on the alpha1- and beta-adrenergic reactions of arterial vessels of the small intestine in rabbits].
Changes in major paraments of alpha 1- and beta-adrenergic responses (EC50 and Pm) were studied in the intestine arterial blood vessels of rabbits adapted to cold for 1-30 days (daily cold exposures for 6 hours at -10 degrees C). It was shown that responses to phenylephrine, noradrenaline, adrenaline (alpha 1-agonists), isopropylnoradrenaline (beta-agonist) corresponded to the equation p = (Pm.An)/(EC50n + An) with n = 1 and n = 2, respectively. Adaptation to cold induced radically different changes in the major parameters of alpha- and beta-adrenergic responses. In the alpha-adrenergic responses, the parameters EC50 and Pm changed reciprocally. In the beta-adrenergic response, only Pm value changed while EC50 did not differ from the control over the entire period of adaptation to cold. The pronounced differences from the control gradually decreased within 1-30 days of adaptation.
Anan'ev
V N
VN
Institute of Developmental Biology, Russian Acad. Sci., 26 Vavilov St., Moscow 119334, Russia.
Anan'eva
O V
OV
Kichikulova
T P
TP
Manukhin
B N
BN
D000222:Adaptation, Physiological / Q000502:physiology*; D000322:Adrenergic Agonists / Q000494:pharmacology; D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000378:metabolism; D003080:Cold Temperature; D007421:Intestine, Small / Q000098:blood supply*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011817:Rabbits; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism / Q000502:physiology*
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D018340:Receptors, Adrenergic, alpha-1; D011943:Receptors, Adrenergic, beta