[Analyses of EGF and TNF contents in fetal wound healing process].
OBJECTIVE
To investigate the role of EGF and TNF in the fetal wound healing process.


METHODS
On a fetal wound healing model with the maternal rabbit on 22-23 days of pregnancy (term = 31-32 days), the contents of EGF and TNF were analyzed with a RIA kit, compared to the maternal rabbit group and the adult rabbit group.


RESULTS
The EGF and TNF contents in the fetal wound were both increasing 3 days after the operation and maintained in a high level until the 7th day of the wound healing process(P < 0.05). However, the EGF and TNF contents in the maternal and adult rabbit groups were only kept at a high level during the 3 days after the surgery.


CONCLUSIONS
The results are indicated that the EGF and TNF may play an important role in fetal wound healing.
Feng
Guoping
G
Plastic Surgery Hospital of China Academy of Medical Science and Peking Union Medical College, Beijing 100041, China.
Sun
Guangci
G
Guan
Zhengyu
Z
D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism* / Q000601:surgery; D011247:Pregnancy; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014945:Wound Healing
D014409:Tumor Necrosis Factor-alpha; D004815:Epidermal Growth Factor