Induced hypothermia in experimental traumatic spinal cord injury: an update.
The use of induced hypothermia in the treatment of traumatic spinal cord injury (SCI) has been studied extensively between the 1960s and 1970s. Although the treatment showed some promise, it became less popular by the 1980s, mainly because of its adverse effects. However, a revival of hypothermia in the treatment of traumatic brain injury (TBI) in the last decade has encouraged neuroscientists to conduct experiments to reevaluate the potential benefits of hypothermia in traumatic SCI. All laboratory investigations studying the mechanisms of action and/or the efficacy of induced hypothermia in treating experimental traumatic SCI published in the last decade were reviewed. Although efficacy of hypothermia in improving functional outcome of mild to moderate traumatic SCI has been demonstrated, hypothermia may not be protective against severe traumatic SCI. At present, induced hypothermia has yet to be recognized or approved as a potential treatment having therapeutic value for traumatic SCI in humans. The continued search for a possible synergistic effect of induced hypothermia and pharmacological therapy may yield some promise. It has also been deduced from these laboratory studies that hyperthermia is deleterious and rigorous measures to prevent hyperthermia should be taken to minimize the propagation of secondary neuronal damage after traumatic SCI.
Inamasu
Joji
J
Department of Neurosurgery, National Tokyo Medical Center, Higashigaoka 2-5-1, Meguro, Tokyo 152-8902, Japan. GInamasu@aol.com
Nakamura
Yoshiki
Y
Ichikizaki
Kiyoshi
K
D000818:Animals; D001831:Body Temperature; D004195:Disease Models, Animal; D006801:Humans; D007036:Hypothermia, Induced; D013119:Spinal Cord Injuries / Q000628:therapy*; D016896:Treatment Outcome