Sildenafil does not alter nelfinavir pharmacokinetics.
The objective of this study was to investigate if sildenafil influences the pharmacokinetics of nelfinavir. Five HIV-infected patients on steady-state nelfinavir-containing therapy were subject to pharmacokinetic sampling for nelfinavir concentration twice: without sildenafil and with sildenafil 25 mg as a single dose. There were no differences in the AUC, T(max), or C(max) of nelfinavir. In a similar design, two patients on indinavir and two patients on ritonavir combined with saquinavir were studied. In accordance with the literature, neither of these two treatments was affected. It is concluded that nelfinavir pharmacokinetics were unaffected by concomitant intake of a single dose of sildenafil.
Bratt
Göran
G
Karolinska Institute, Gay Men's Health Clinic (Venhälsan), Stockholm Söder Hospital, Stockholm, Sweden.
Ståhle
Lars
L
D000328:Adult; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D019469:Indinavir / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D019888:Nelfinavir / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011687:Purines; D019438:Ritonavir / Q000493:pharmacokinetics; D019258:Saquinavir / Q000493:pharmacokinetics; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D017320:HIV Protease Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D019469:Indinavir; D000068677:Sildenafil Citrate; D019888:Nelfinavir; D019258:Saquinavir; D019438:Ritonavir