Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity.
The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity.
Ravikanth
Veluri
V
Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Lakshmi Niranjan Reddy
Vanimireddy
V
Vijender Reddy
Adelli
A
Ravinder
Kodela
K
Prabhakar Rao
Tadikamalla
T
Siva Ram
Tejomoorty
T
Anand Kumar
Kondapi
K
Prakesh Vamanarao
Diwan
D
Venkateswarlu
Yenamandra
Y
D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D028481:Euphorbia; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003603:Cytotoxins; D004224:Diterpenes; D010936:Plant Extracts