The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer.
We examined the vascular endothelial growth factor (VEGF) levels in peripheral blood and drainage vein (plasma and serum), and then these were compared with local VEGF expression from gastric cancer. Peripheral blood plasma VEGF levels was increased in the patients with venous invasion, and moderately correlated with the number and ratio of lymph nodes with metastasis. Local VEGF expression was correlated significantly with tumor size, advanced stage and lymph node metastasis, but not correlated with peripheral VEGF levels. The level of plasma VEGF in peripheral veins is one of the sensitive markers of the status of gastric cancer.
Ohta
Manabu
M
2nd Department of Surgery, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu 431-3192, Japan. otam@hama-med.ac.jp
Konno
Hiroyuki
H
Tanaka
Tatsuo
T
Baba
Megumi
M
Kamiya
Kinji
K
Syouji
Tuyoshi
T
Kondoh
Kenji
K
Watanabe
Masaya
M
Terada
Hirofumi
H
Nakamura
Satoshi
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A
D043925:Angiogenesis Inducing Agents; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A