[Diffuse pulmonary ossifications with mortal consequences. A case report].
Dendriform pulmonary ossification (DPO) represents a relatively frequent form of diffuse pulmonary and mostly clinically inapparent bone formation of unknown etiology. An association with other pulmonary diseases, particularly pulmonary interstitial fibrosis, has been suggested. Here we report a female patient with a 15-year history of DPO whereby at the age of 48 an X-ray of the thorax first revealed findings suggestive of pulmonary fibrosis. For 9 years the patient suffered from chronic progressive ventilation disorder and after a further 3 years open lung biopsy revealed DPO in conjunction with interstitial fibrosis. After a history of progressive respiratory failure the patient suddenly died of cardiac arrhythmia along with deteriorated cor pulmonale at the age of 71. Autopsy revealed an almost complete ossification of the lungs with an increasing gradient from apex to base. In contrast to previous reports, the DPO of our patient was life-limiting.
Reinehr
M
M
Institut für Pathologie, Universität Ulm.
Rittinger
M
M
Müller-Wening
D
D
Wagner
T
T
Gabelmann
A
A
Möller
P
P
Scheil
Stefanie
S
D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000473:pathology*