Role of hormonal risk factors in HER2-positive breast carcinomas.
Examination of parity, age at menarche and at menopause by HER2 status in a large series of breast carcinomas showed a statistically significant increased-frequency of HER2-positive tumours in lower risk subgroups. The findings suggest a difference in the protective role of hormone-related risk factors between HER2-positive and -negative tumours.
Balsari
A
A
Istituto Nazionale Tumori, Milano, Italy.
Casalini
P
P
Bufalino
R
R
Berrino
F
F
Ménard
S
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D008572:Menarche; D008593:Menopause; D008875:Middle Aged; D010298:Parity; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D012307:Risk Factors
D018719:Erb-b2 Receptor Tyrosine Kinases