Lipase catalysis in ionic liquids and supercritical carbon dioxide at 150 degrees C.
Free and immobilized Candida antarctica lipase B dispersed in ionic liquids (1-ethyl-3-methylimidazolium bistriflimide and 1-buthyl-3-methylimidazolium bistriflimide) were used as catalyst for the continuous kinetic resolution of rac-1-phenylethanol in supercritical carbon dioxide at 120 and 150 degrees C and 10 MPa. Excellent activity, stability and enantioselectivity levels were recorded in continuous operation.
Lozano
Pedro
P
Departamento de Bioquímica y Biología Molecular B e Inmunología, Facultad de Química, Universidad de Murcia, P.O. Box 4021, E-30100 Murcia, Spain.
De Diego
Teresa
T
Carrié
Daniel
D
Vaultier
Michel
M
Iborra
José L
JL
D019149:Bioreactors; D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D004789:Enzyme Activation; D004795:Enzyme Stability; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D006358:Hot Temperature; D007093:Imidazoles / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008049:Lipase / Q000737:chemistry*; D010626:Phenylethyl Alcohol / Q000737:chemistry*; D011312:Pressure; D012996:Solutions
D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D007093:Imidazoles; D007094:Imides; D007477:Ions; D012996:Solutions; D002245:Carbon Dioxide; C093667:Novozyme 435; D008049:Lipase; C431349:lipase B, Candida antarctica; D010626:Phenylethyl Alcohol