title: [Osseous defect regeneration using autogenous bone alone or combined with Biogran or Algipore with and without added thrombocytes. A microradiologic evaluation].
abstract: In addition to autogenous bone, a variety of bone substitute materials is used to regenerate bony defects. The aim of the study was to evaluate the reossification of critical size defects in the os frontale of adult pigs ( n=16) with microradiography. The defects were filled randomly with autogenous bone or the bone substitute materials Algipore and Biogran each combined with a defined quantity of autogenous bone. Additionally, platelet-rich plasma (PRP) was added in defined quantities (0.5 ml) in two different concentrations (4-fold and 6.5-fold). At 2, 4, 12, and 26 weeks four animals were sacrificed and the osseous regeneration documented by quantitative evaluation of the microradiographic findings. Microradiographic results in the autogenous bone group showed an earlier PRP concentration-dependent mineralization. Over the whole observation period the peak value of autogenous bone as filler alone could not be reached in both PRP groups. Using Algipore, no accelerated effect of mineralization however could be observed. In our study, Biogran proved to be a defect filler only partially suitable for bony defect healing, no matter whether PRP was added or not.
authors.affiliation: Klinik und Poliklinik für Mund-; Kiefer- und Gesichtschirurgie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstrasse 11, 91054 Erlangen. schlegel@mkg.med.uni-erlangen.de
authors.forename: K A
authors.initials: KA
authors.lastname: Schlegel
authors.forename: F R
authors.initials: FR
authors.lastname: Kloss
authors.forename: S
authors.initials: S
authors.lastname: Schultze-Mosgau
authors.forename: F W
authors.initials: FW
authors.lastname: Neukam
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation; D004338:Drug Combinations; D005898:Glass; D008852:Microradiography; D009583:Nitrofurazone / Q000494:pharmacology*; D010976:Platelet Count; D017713:Platelet Transfusion; D013552:Swine
chemical_list: D000464:Alginates; C073544:Biogran; D018786:Bone Substitutes; D004338:Drug Combinations; C043283:alginic acid, nitrofurazone drug combination; D009583:Nitrofurazone