[Application of SCID mouse-human leukemia model for leukemia research].
SCID mouse-human leukemia model is an important and useful tool for study on proliferation, differentiation and modulation of leukemic cells. In this article, the establishment of the model, advances in research and application in studies of pathogenesis, cell biology, clinical diagnosis, therapy and assessment of prognosis of leukemia patients are reviewed. The limitations of the model are also commented.
Nie
Xiao-Meng
XM
Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Lou
Jing-Wei
JW
Wang
Jian-Min
JM
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D051379:Mice; D016513:Mice, SCID; D012107:Research Design