Cyclooxygenase-2 expression associated with spreading depression in a primate model.
The authors previously provided evidence that spreading depression (SD) can be evoked in primates. Cyclooxygenase-2 (COX-2) expression has been found to increase in the rodent cortex undergoing SD, and the authors sought to determine whether this association exists in primate brain. In the present study, neuronal COX-2 expression was induced during SD in the primate cortex. The mean expression ratio of COX-2 messenger RNA in animals with SD was significantly higher than that measured in controls (1.69 vs. 0.5; P = 0.02). Induction of COX-2 in these animals was also detected by human microarray analysis. Results show that, as in rodents, neuronal COX-2 is induced in the primate cortex in response to SD.
Yokota
Chiaki
C
Cerebrovascular Laboratory, Department of Pathogenesis, National Cardiovascular Center Research Institute, Osaka, Japan. cyokota@ri.ncvc.go.jp
Inoue
Hiroyasu
H
Kuge
Yuji
Y
Abumiya
Takeo
T
Tagaya
Masafumi
M
Hasegawa
Yasuhiro
Y
Ejima
Norimasa
N
Tamaki
Nagara
N
Minematsu
Kazuo
K
D000818:Animals; D001921:Brain / Q000201:enzymology*; D013181:Cortical Spreading Depression / Q000502:physiology*; D051546:Cyclooxygenase 2; D015971:Gene Expression Regulation, Enzymologic; D007527:Isoenzymes / Q000235:genetics*; D008252:Macaca fascicularis; D008297:Male; D023421:Models, Animal; D020411:Oligonucleotide Array Sequence Analysis; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
D007527:Isoenzymes; D012333:RNA, Messenger; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases