Novel consecutive beta- and gamma-turn mimetics composed of alpha-aminooxy tripeptides.
[structure: see text] To develop novel consecutive beta- and gamma-turn mimetics, we designed and characterized alpha-aminooxy tripeptides (trimers) consisting of oxanipecotic acid dimer and alpha-aminooxy acid. According to FT-IR and NMR data, as well as ab initio quantum calculations, the trimers adopted unusual folded structures with consecutive beta- and gamma-turnlike conformations.
Baek
Bong-Hyeon
BH
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lee
Myung-Ryul
MR
Kim
Kwang-Yon
KY
Cho
Ung-In
UI
Boo
Doo Wan
DW
Shin
Injae
I
D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017550:Spectroscopy, Fourier Transform Infrared
D010455:Peptides