Effect of beta-endorphin and beta-endorphin-like peptide immunorphin on the growth of human leukemic cells in vitro.
The influence of beta-endorphin and immunorphin on human leukemic cell growth in vitro was studied. It was shown that both peptides increase the growth of T-lymphoblastoid cells in a dose-dependent manner. The effect of these peptides on the 3H-thymidine incorporation into T-lymphoblastoid cell line Jurkat was not reversed by the antagonist of opioid receptor naloxone. Interestingly, these peptides had no effect on B-lymphoblastoid and promyelocyte cell growth, however they enhance 3H-thymidine incorporation into myeloid cell lines.
Malkova
Natalya V
NV
Engelhardt Institute of Molecular Biology, Branch of M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. malkova@fibkh.serpukhov.su
Krasnova
Svetlana B
SB
Navolotskaya
Elena V
EV
Zargarova
Tatyana A
TA
Prasolov
Vladimir S
VS
D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007127:Immunoglobulin Constant Regions; D007142:Immunoglobulin gamma-Chains; D019169:Jurkat Cells; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology*; D008934:Mitogens / Q000378:metabolism / Q000494:pharmacology; D009270:Naloxone / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D001615:beta-Endorphin / Q000378:metabolism / Q000494:pharmacology*
D007127:Immunoglobulin Constant Regions; D007142:Immunoglobulin gamma-Chains; D008934:Mitogens; D009842:Oligopeptides; D010446:Peptide Fragments; C445661:immunorphin; D009270:Naloxone; D001615:beta-Endorphin