[The use of L-tryptophan for correction of disbalance of central neurotransmitters in morphine withdrawal syndrome].
The influence of tryptophan on the content of central neurotransmitters (free amino acids and biogenous amines) in various structures of the rat brain under the conditions of morphine withdrawal has been studied. It is established that the chronic morphine intoxication followed by withdrawal lead to activation of the dopaminergic system and to an increase in the content of exciting amino acids in the rat brain. The morphine withdrawal syndrome is accompanied by inhibition of the serotoninergic activity in all rat brain structures studied. The administration of L-tryptophan (100 mg/kg, i.p.) on the morphine withdrawal syndrome activates the central serotoninergic structures and prevents from further increase in the content of exciting amino acids in the brain.
Razvodovskiĭ
Iu E
IuE
Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, 230017 Belarus.
Doroshenko
E M
EM
Selevich
M I
MI
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000378:metabolism*; D014364:Tryptophan / Q000627:therapeutic use*
D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D009020:Morphine; D014364:Tryptophan