title: Successful use of 6 antigen HLA mismatched kidneys for cadaveric renal transplantation.
abstract: OBJECTIVE
  We retrospectively evaluated the outcome of transplantation with kidneys with 6 antigen HLA mismatches.
  
  
  METHODS
  From October 1990 to September 2001, 1,270 cadaveric renal transplants were performed at our center, including 33 (2.59%) involving recipients of kidneys with 6 antigen HLA mismatches. Mean recipient age +/- SD was 40.2 +/- 14.4 years. Of the 33 recipients 19 were male, 14 were female, 31 received an initial transplant, 4 had diabetes and 6 had panel-reactive antibodies of greater than 10%. Mean donor age was 30.3 +/- 13.7 years and mean cold ischemia time was 22.9 +/- 7.8 hours. All recipients had negative current and previous B and T-cell lymphocytotoxicity cross-matching and all received a triple immunosuppression regimen consisting of the calcineurin inhibitor cyclosporine or tacrolimus combined with steroids and azathioprine.
  
  
  RESULTS
  One-year patient and graft survival was 93.3% and 93.7%, respectively. Of the 33 grafts 31 (94%) functioned immediately. During the mean followup of 3.31 years 10 grafts (30%) were lost, including 6 (60%) due to death with a functioning graft and 4 due to chronic rejection. Acute rejection in 8 patients (24%) was reversed in 7 by steroid pulses. No graft was lost to acute rejection. Technical complications included wound infection in 2 patients (6%), transplant-ureteral obstruction in 1 (3%) and a urinary fistula in 1 (3%).
  
  
  CONCLUSIONS
  Kidneys with 6 antigen HLA mismatches can be used effectively.
authors.affiliation: Department of Urology and Transplantation, Beaumont Hospital, Dublin, Ireland.
authors.forename: Khalid Chiad
authors.initials: KC
authors.lastname: Safi
authors.forename: Ponnusamy
authors.initials: P
authors.lastname: Mohan
authors.forename: Ming
authors.initials: M
authors.lastname: Lee
authors.forename: Dilly M
authors.initials: DM
authors.lastname: Little
authors.forename: Mary G
authors.initials: MG
authors.lastname: Donovan
authors.forename: Tom A
authors.initials: TA
authors.lastname: Creagh
authors.forename: Denis M
authors.initials: DM
authors.lastname: Murphy
authors.forename: Patrick
authors.initials: P
authors.lastname: O'Kelly
authors.forename: David P
authors.initials: DP
authors.lastname: Hickey
mesh_terms: D000328:Adult; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D015234:HLA-A Antigens / Q000276:immunology*; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D015234:HLA-A Antigens