title: Innovations in design and delivery of chemotherapy for brain tumors.
abstract: Effectiveness of chemotherapy in patients with brain tumors is hampered by the presence of the blood-brain barrier and drug resistance. In recent years, significant progress has been made in devising innovative methods of design and delivery of chemotherapy for brain tumors. This article has surveyed the issues of blood-brain barrier and drug resistance and explored some of the strategies used to circumvent problems associated with chemotherapy failure in patients with brain tumors.
authors.affiliation: Department of Pediatric Clinical Services, Brain Tumor Center at Duke, Box 3624, Duke University Medical Center, Durham, NC 27710, USA. gurur002@mc.duke.edu
authors.forename: Sridharan
authors.initials: S
authors.lastname: Gururangan
authors.forename: Henry S
authors.initials: HS
authors.lastname: Friedman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D006801:Humans; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents