Fas/Apo-1 (CD95) Antigen Expression on the Peripheral Blood Lymphocytes in Healthy Donors and Pulmonary Tuberculosis Patients.
As well as the proliferation of antigen-specific T and B cells the programmed cell death (apoptosis) of lymphocytes is one of the key mechanisms of the immune homeostasis regulation. The apoptosis of immunocytes is associated with the expression of Fas/Apo-1 (CD95) glycoprotein. The expression of Fas/Apo-1 (CD95) on the peripheral blood lymphocytes from 45 healthy donors and 45 patients with pulmonary tuberculosis was studied. The percentage of CD95(+) lymphocytes of the healthy donors was 40.1 +/- 10.9, significant correlation of this parameter with the percentage of CD3(+) and CD4(+) lymphocytes was observed. In patients with pulmonary tuberculosis the percentage of CD95(+) lymphocytes was 47.0 +/- 15.9. In this case the correlations between the percentage of CD95(+) lymphocytes, CD72(+) B cells, CD25(+) lymphocytes and HLA DR(+) cells and serum IgA level were observed. Using the procedure of cluster analysis it was shown that extremal number of the CD95(+) lymphocytes is typical for the patients with the prognostically unfavorable immune abnormalities and clinic picture, high levels of serum TNFalpha and hypercortisolemia. It is tempting to speculate that apoptosis of T cells (possibly Th1 cells) is of great importance in the pathogenesis of the immunodeficiency associated with the micobacteriosis.
Sibiryak
Sergey V.
SV
Russian Center of Ocular and Plastic Surgery, Ufa, Russia.
Yusupova
Rina Sh.
RS
Kayumova
Eleonora U.
EU