title: Course of Modic 1 six months after lumbar posterior osteosynthesis.
abstract: METHODS
  A prospective study was conducted to investigate the outcome of the Modic Type 1 inflammatory signal in magnetic resonance imaging (MRI) in 17 patients with chronic low back pain 6 months after instrumented posterior lumbar arthrodesis.
  
  
  OBJECTIVE
  To assess the course of the inflammatory signal after stabilization of a painful intervertebral segment by posterior instrumentation alone visualized on MRI systematically performed 6 months after the operation.
  
  
  BACKGROUND
  In 1988, Modic and colleagues described three degenerative stages of vertebral endplates and subchondral bone. The inflammatory stage, or Stage 1, is correlated with substantial functional disability. According to these authors, Stage 1 lesions naturally transform into Stage 2, the fatty stage. In the literature, patients with Modic 1 signal tend to have good results after arthrodesis, better than those with Modic 2 lesions.
  
  
  METHODS
  This study included 17 patients (average age, 46 years) who had experienced chronic low back pain more than 1 year and showed Modic 1 changes in MRI and disc narrowing on plain radiographs. Every patient underwent posterior screw-rod osteosynthesis and posterolateral arthrodesis. Disc disease had occurred subsequently to discectomy (n = 7), rapidly destructive disc disease (n = 5), or spondylolisthesis resulting from spondylolysis (n = 5). Clinical results were assessed according to a visual analog scale for pain, a functional disability score for the evaluation of patients with low back pain (Eiffel), and the validated French version of the self-administered Dallas quality-of-life test (DRAD).
  
  
  RESULTS
  Systematic MRI at 6 months showed transformation from Modic 1 to Modic 0 (normal endplate signal) in 4 patients and transformation from Modic 1 to Modic 2 in the remaining 13 patients. Clinical evaluation was performed at 6 months (at the same time as the MRI) and at 1 year. In every patient, there was improvement in the visual analog score and the functional score, which remained stable at 1 year.
  
  
  CONCLUSIONS
  According to the literature, most Modic 1 lesions change to become Stage 2 lesions in 18 to 24 months. In this study, 17 patients with Modic Type 1 signal had changes after 6 months. It appears that posterior osteosynthesis combined with posterolateral arthrodesis accelerates the course of Modic 1 lesions, probably by correcting mechanical instability.
authors.affiliation: Unité de Pathologie Rachidienne, Hôpital Tripode, Centre Hospitalo-Universitaire, Place Amélie Raba Léon, 33076 Bordeaux Cedex, France. jmvital@aol.com
authors.forename: J M
authors.initials: JM
authors.lastname: Vital
authors.forename: O
authors.initials: O
authors.lastname: Gille
authors.forename: V
authors.initials: V
authors.lastname: Pointillart
authors.forename: M
authors.initials: M
authors.lastname: Pedram
authors.forename: P
authors.initials: P
authors.lastname: Bacon
authors.forename: F
authors.initials: F
authors.lastname: Razanabola
authors.forename: C
authors.initials: C
authors.lastname: Schaelderle
authors.forename: S
authors.initials: S
authors.lastname: Azzouz
mesh_terms: D000328:Adult; D002908:Chronic Disease; D017586:Diskectomy / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D017116:Low Back Pain / Q000175:diagnosis / Q000209:etiology; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology*; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011788:Quality of Life; D011859:Radiography; D013123:Spinal Fusion / Q000009:adverse effects / Q000379:methods; D013168:Spondylolisthesis / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome