[Changes in indicators of external and internal secretion of the pancreas during treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogs].
OBJECTIVE
To study somatostatin (SS) content in patients with chronic pancreatitis (CP) and effects of sandostatin (a synthetic analogue of SS) on endo- and exocrine pancreatic functions in CP patients.


METHODS
SS plasma levels were measured by radioimmunoassay in basal conditions in 32 CP patients. Sandostatin treatment was given to 20 patients with CP of alcohol etiology (twice a day subcutaneously for 5 days). In the course of the treatment the following indices were measured: serum trypsin, amilase, lipase, alpha 2-macroglobulin, general antitryptic activity, blood immunoreactive insulin in basal conditions and after intravenous injection of glucose.


RESULTS
SS levels in peripheral blood were elevated in patients with complicated alcoholic CP. Sandostatin in CP used for 5 days had no significant impact on insulin secretion, levels of pancreatic enzymes, inhibiting system of blood. 90% patients with alcoholic CP experienced relief of pain which may relate to suppression of stimulated secretion of gastrointestinal hormones as well as to a favourable action of sandostatin on stabilization of membranes of acinar cells.


CONCLUSIONS
Sandostatin administration in CP patients is justified and is especially recommended in the complicated course.
Vinokurova
L V
LV
Astaf'eva
O V
OV
Banifatov
P V
PV
D000328:Adult; D002908:Chronic Disease; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D019512:Pancreatitis, Alcoholic / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use*
D000431:Ethanol; D013004:Somatostatin