title: Optoacoustic tomography using time-resolved interferometric detection of surface displacement.
abstract: We introduce a minimally invasive technique for optoacoustic imaging of turbid media using optical interferometric detection of surface displacement produced by thermoelastic stress transients. The technique exploits endogenous or exogenous optical contrast of heterogeneous tissues and the low attenuation of stress wave propagation to localize and image subsurface absorbers in optically turbid media. We present a system that utilizes a time-resolved high-resolution interferometer capable of angstrom-level displacement resolution and nanosecond temporal resolution to detect subsurface blood vessels within model tissue phantoms and a human forearm in vivo.
authors.affiliation: Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, Massachusetts 02139, USA.
authors.forename: Barry P
authors.initials: BP
authors.lastname: Payne
authors.forename: Vasan
authors.initials: V
authors.lastname: Venugopalan
authors.forename: Bora B
authors.initials: BB
authors.lastname: Mikić
authors.forename: Norman S
authors.initials: NS
authors.lastname: Nishioka
mesh_terms: D000042:Absorption; D000162:Acoustics / Q000295:instrumentation; D001808:Blood Vessels / Q000502:physiology / Q000648:ultrastructure; D003238:Connective Tissue / Q000502:physiology* / Q000648:ultrastructure*; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007834:Lasers; D008857:Microscopy, Interference / Q000295:instrumentation* / Q000379:methods*; D009038:Motion; D019047:Phantoms, Imaging; D010865:Pilot Projects; D012542:Scattering, Radiation; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*