Pharmacotherapy of postoperative nausea and vomiting.
Postoperative nausea and vomiting (PONV) are two of the most common and unpleasant side effects following anaesthesia and surgery. Despite the development of new anti-emetics and a vast amount of published research, PONV continues to be a problem, especially in high-risk patients. Recent interest has focused on the use of a combination of agents, acting on different receptors and the adoption of a multimodal approach to tackle this problem. The search for the most cost-effective strategy has also been a major goal. This article will discuss the risk factors and physiology of PONV, currently available therapies, the use of a multimodal approach and the cost-effectiveness of PONV management. Finally, recommendations for the prophylaxis and treatment of PONV will be discussed.
Habib
Ashraf S
AS
Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA.
Gan
Tong J
TJ
D000932:Antiemetics / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D004358:Drug Therapy; D005260:Female; D006801:Humans; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use
D000932:Antiemetics; D017366:Serotonin Receptor Agonists