Physicochemical properties of stomatological dressings on the basis of biodegradable nonionic polymers.
The properties of polyvinyl alcohol (PVA), such as the ability to form membranes, good relative bioadhesiveness, the ability to mix with other polymers, biodegradability, swelling in water, lead to an assumption that the polymer may be used effectively as a carrier of the active substance onto the mucous membranes, what has led us to undertake present studies [1-4]. They revealed that depending on the degree of polyalcohol hydrolysis, the dressings made on the basis of PVA and methylcellulose (MC) with the addition of hydrophilic substances were characterised by distinct rheological properties and released the active substance in various ways. The studies on the kinetics of the release of a locally applied antiseptic, chlorhexidine digluconate, in biopharmaceutical model provided evidence of close to rectilinear relationship between the amount of released substance and the time of release for selected formulations.
Pluta
Janusz
J
Department of Dispensing Pharmacy, Wrocław Medical Academy.
Karolewicz
Bozena
B
D000269:Adhesives; D000278:Administration, Buccal; D000287:Administration, Topical; D001458:Bandages; D001673:Biodegradation, Environmental; D002626:Chemistry, Pharmaceutical; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004337:Drug Carriers; D006801:Humans; D020100:Hydrogels; D008422:Materials Testing; D009824:Ointments; D010518:Periodontitis / Q000188:drug therapy; D012212:Rheology
D000269:Adhesives; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D009824:Ointments; C010882:chlorhexidine gluconate; D002710:Chlorhexidine