[Molecular mechanisms behind the immunological reaction against gluten in patients with celiac disease].
Coeliac disease is a complex inflammatory disorder of the small intestine, induced by dietary gluten in genetically susceptible individuals. Recently, the nature of gluten-derived peptides recognized by gut-derived T cells from patients has been elucidated. It has further been established that the binding of such peptides to HLA-DQ2 and DQ8 molecules is enhanced following the modification of the peptides by the ubiquitous enzyme tissue transglutaminase. This knowledge has allowed the establishment of a molecular basis for the well-known association between coeliac disease and the expression of these HLA-molecules. This article summarizes the latest progress in coeliac disease molecular biology.
Nielsen
Christian
C
Odense Universitetshospital, Klinisk Immunologisk Afdeling, Paediatrisk Afdeling.
Husby
Steffen
S
Lillevang
Søren T
ST
D000818:Animals; D001323:Autoantibodies / Q000235:genetics; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007421:Intestine, Small / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D006683:HLA-DQ Antigens; D005983:Glutens