A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report.
OBJECTIVE
The objective was to investigate the presence of Helicobacter pylori with polymerase chain reaction in the sinonasal mucosa of patients with or without chronic rhinosinusitis (CRS).


METHODS
A prospective clinical trial.


METHODS
Mucosal tissue samples were collected from ethmoid cells of 12 patients with CRS and the removed mucosal part of the middle concha of 13 patients with concha bullosa who were treated surgically in our institution. DNA extracted from these samples was used for the amplification of 16S ribosomal RNA gene of H pylori by nested polymerase chain reaction.


RESULTS
Helicobacter pylori DNA was detected in 4 of 12 patients with CRS, but it was not detected in patients with concha bullosa. Three of four patients with positive results for H pylori had gastroesophageal reflux-related complaints.


CONCLUSIONS
It is possible to detect H pylori in the sinus mucosa of some patients with CRS. However, whether H pylori is a causative agent for CRS or a result of CRS is not known.
Ozdek
Ali
A
Department of Otorhinolaryngology, Ankara Research and Training Hospital, Ministry of Health, Ankara, Turkey. Ozdek@ttnet.net.tr
Cirak
Meltem Yalinay
MY
Samim
Erdal
E
Bayiz
Unal
U
Safak
Mustafa Asim
MA
Turet
Sevgi
S
D000328:Adult; D002908:Chronic Disease; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005764:Gastroesophageal Reflux / Q000382:microbiology; D016481:Helicobacter Infections / Q000235:genetics / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000235:genetics / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
D017931:DNA Primers