The structural biology of type I viral membrane fusion.
The fusion of viral membranes with target-cell membranes is an essential step in the entry of enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins have provided new insights into protein-mediated plasma-membrane fusion. Here, we review our understanding of the structural transitions that are involved in this fusion pathway, compare it to our understanding of influenza virus membrane fusion, and discuss the implications for retroviral membrane fusion.
Colman
Peter M
PM
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. pcolman@wehi.edu.au
Lawrence
Michael C
MC
D015686:Gene Products, env / Q000502:physiology / Q000648:ultrastructure; D006678:HIV / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000235:genetics; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000235:genetics; D008561:Membrane Fusion / Q000502:physiology*; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018406:Virus Physiological Phenomena
D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D014760:Viral Fusion Proteins