title: Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.
abstract: Alteration of mRNA sequence through base modification mRNA editing frequently generates protein diversity. Several proteins have been identified as being similar to C-to-U mRNA editing enzymes based on their structural domains and the occurrence of a catalytic domain characteristic of cytidine deaminases. In light of the hypothesis that these proteins might represent novel mRNA editing systems that could affect proteome diversity, we consider their structure, expression and relevance to biomedically significant processes or pathologies.
authors.affiliation: Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14623, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Wedekind
authors.forename: Geoffrey S C
authors.initials: GS
authors.lastname: Dance
authors.forename: Mark P
authors.initials: MP
authors.lastname: Sowden
authors.forename: Harold C
authors.initials: HC
authors.lastname: Smith
mesh_terms: D000071479:APOBEC-1 Deaminase; D000595:Amino Acid Sequence; D000818:Animals; D001055:Apolipoproteins B / Q000096:biosynthesis / Q000235:genetics*; D003564:Cytidine Deaminase / Q000502:physiology*; D008322:Mammals / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D025542:Neurofibromin 1 / Q000096:biosynthesis / Q000235:genetics; D017393:RNA Editing / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D001055:Apolipoproteins B; D025542:Neurofibromin 1; D012333:RNA, Messenger; D000071479:APOBEC-1 Deaminase; C000605090:Apobec1 protein, mouse; D003564:Cytidine Deaminase