title: Antitumor activity of flavones isolated from Artemisia argyi.
abstract: The flavones 5,6-dihydroxy-7,3',4'-trimethoxyflavone ( 1), 5,6,4'-trihydroxy-7,3'-dimethoxyflavone ( 2), 5-hydroxy-3',4',6,7-tetramethoxyflavone, 5,7,3'-trihydroxy-6,4',5'-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC 50 values of 25 - 200 microg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds 1 and 2 inhibited growth of a colon tumor (SW620) by 44.6 % and 14.6 %, respectively.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Uen-dong, Yoosung-gu, Taejon, Republic of Korea.
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Seo
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Jong Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Soo-Ik
authors.initials: SI
authors.lastname: Chang
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology*; D019306:Artemisia; D002642:Chick Embryo / Q000187:drug effects; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts