Bridging the synthetic and biopolymer worlds with peptide-drug conjugates.
Roberts and Li break the standard library mold by generating hybrid libraries of small molecules tethered to peptides. Hybrid libraries harness larger chemical and structural diversities and thus represent a new frontier in lead drug discovery.
Weiss
Gregory A
GA
Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Chamberlin
Richard
R
D001704:Biopolymers / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D001704:Biopolymers; D019151:Peptide Library; D010455:Peptides; D004364:Pharmaceutical Preparations