Atherothrombosis, inflammation, and diabetes.
Diabetes represents a major cause of cardiovascular morbidity and mortality in developed countries, and atherothrombosis accounts for most deaths among diabetics. Recent evidence has reliably shown the relevant etiopathogenetic role of inflammation in atherothrombotic disease. This review summarizes and discusses the possible synergistic effects of diabetes and inflammation in promoting atherothrombosis and its complications, as well as potential avenues for diagnostic, preventive, and therapeutic benefits in the modulation of inflammatory mechanisms in diabetic atherothrombotic disease.
Biondi-Zoccai
Giuseppe G L
GG
Institute of Cardiology, Catholic University, Rome, Italy.
Abbate
Antonio
A
Liuzzo
Giovanna
G
Biasucci
Luigi M
LM
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology; D014157:Transcription Factors / Q000378:metabolism
D015415:Biomarkers; D014157:Transcription Factors