Comparison of gallbladder function obtained with regular CCK-8 and pharmacy-compounded CCK-8.
This study was undertaken to test whether the octapeptide of cholecystokinin (regular CCK-8) and pharmacy-compounded CCK-8 produce similar results with regard to gallbladder function.


METHODS
Twenty patients with suspected gallbladder disease were enrolled into quantitative cholescintigraphy. Each patient was infused for 10 min with 3 ng/kg/min of regular CCK-8 and pharmacy-compounded CCK-8, sequentially, with a 30-min interval between the beginning of infusion. The gallbladder ejection fraction, latent period, ejection period, and ejection rate were measured with both agents.


RESULTS
Both regular CCK-8 and pharmacy-compounded CCK-8 produce similar, but not identical, results with close correlation between them with reference to all of the measured functions of the gallbladder. There is neither potentiation nor inhibition of the first dose on the effects of the second dose of CCK-8.


CONCLUSIONS
Pharmacy-compounded CCK-8 functions much similar to that of regular CCK-8 as long as an interval of at least 30 min is allowed between doses.
Krishnamurthy
Shakuntala
S
Nuclear Medicine Department, Tuality Community Hospital/Tuality Healthcare, 335 SE 8th Avenue, Hillsboro, OR 97123, USA. gtkrishna@aol.com
Cerulli-Switzer
Jeri
J
Chapman
Nicholas
N
Krishnamurthy
Gerbail T
GT
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017277:Drug Approval; D004339:Drug Compounding; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000187:drug effects*; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012844:Sincalide / Q000008:administration & dosage / Q000145:classification; D019785:Technetium Tc 99m Disofenin
D019275:Radiopharmaceuticals; D012844:Sincalide; D019785:Technetium Tc 99m Disofenin