title: Radio-tympano-sinu-orthesis with 186Re-colloid: a new treatment modality for chronic otitis media and paranasal mucositis.
abstract: This preliminary treatment trial was performed to evaluate the safety and clinical efficacy of intracavitary therapy with (186)Re-colloid in patients with recurrent otitis media and paranasal sinusitis, resistant to pharmacotherapy and surgical treatment.
  
  
  METHODS
  Thirty-nine applications of 5-35 MBq (186)Re-colloid into the tympanon and the paranasal sinuses were performed in 6 patients. Biodistribution and biokinetics were studied by gamma-camera imaging. Clinical success was documented 6-20 mo after therapy by each patient's self-evaluation and by rhinootologic follow-up, using a 4-step score.
  
  
  RESULTS
  No harmful side effects were seen. There was good-to-excellent clinical improvement with a score of +1.44 +/- 0.5 by each patient's self-evaluation and by physicians scoring of +0.81 +/- 0.9 with only negligible extracranial tracer deposition.
  
  
  CONCLUSIONS
  This novel treatment option using intracavitary application of (186)Re-colloid in chronic otitis media and sinusitis is safe and effective. The term "radio-tympano-sinu-orthesis" might be proposed analogously to the well-known radiosynoviorthesis.
authors.affiliation: Clinic of Nuclear Medicine, Christian-Albrechts-University, Arnold-Heller-Strasse 9, D-24105 Kiel, Germany. ukampen@nuc-med.uni-kiel.de
authors.forename: Willm U
authors.initials: WU
authors.lastname: Kampen
authors.forename: Godber S
authors.initials: GS
authors.lastname: Godbersen
authors.forename: Norbert
authors.initials: N
authors.lastname: Czech
authors.forename: Otto F
authors.initials: OF
authors.lastname: Besch
authors.forename: Winfried
authors.initials: W
authors.lastname: Brenner
authors.forename: Eberhard
authors.initials: E
authors.lastname: Henze
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002908:Chronic Disease; D003102:Colloids; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000378:metabolism / Q000532:radiotherapy*; D010865:Pilot Projects; D011868:Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D012211:Rhenium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012852:Sinusitis / Q000378:metabolism / Q000532:radiotherapy*; D016896:Treatment Outcome; D014915:Whole-Body Counting
chemical_list: D003102:Colloids; D011868:Radioisotopes; D012211:Rhenium