Organogenesis of lymphoid tissues.
The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.
Mebius
Reina E
RE
Department of Molecular Cell Biology, VU University Medical Center, v.d. Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. r.mebius.cell@med.vu.nl
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D008221:Lymphoid Tissue / Q000196:embryology / Q000254:growth & development* / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D009928:Organ Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015815:Cell Adhesion Molecules; D018925:Chemokines; D008233:Lymphotoxin-alpha