Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.
We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.
Seoud
Muhieddine
M
Obstetrics and Gynecology, The American University of Beirut Medical Center, New York, New York 10022, USA.
Nassar
Anwar
A
Usta
Ihab
I
Mansour
Mohammad
M
Salti
Ibrahim
I
Younes
Khaled
K
D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D001656:Biliary Atresia / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D004064:Digestive System / Q000187:drug effects; D004065:Digestive System Abnormalities; D004933:Esophageal Atresia / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000188:drug therapy; D007231:Infant, Newborn; D008713:Methimazole / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013997:Time Factors; D014138:Tracheoesophageal Fistula / Q000139:chemically induced / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome
D013956:Antithyroid Agents; D008713:Methimazole