Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice.
Conjugated linoleic acids (CLA) are naturally occurring fatty acids that have been recognized to modify prostaglandin (PG) production in specific tissues. So far, no relationship between PG production and CLA has been reported in the brain. Thus, the effects of CLA on cerebral prostaglandin E(2) (PGE(2)) levels and cyclooxygenase (COX)-1 and COX-2 mRNA expression in mice were determined in the present study. Mice given the diet with or without 3% CLA at the age of 9 weeks were mated, reproduced and lactated. Offspring mice given each diet until 25 days and 8 weeks of age were sacrificed and their brains removed. Production of PGE(2) was reduced while COX mRNA was quantitatively increased by CLA supplementation. These results imply that brain PGE(2) production can be reduced by dietary CLA without inhibition of COX gene expression in mice.
Nakanishi
Tomonori
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources, Kyushu University, 812-8581, Fukuoka, Japan.
Koutoku
Tomoyuki
T
Kawahara
Satoshi
S
Murai
Atsushi
A
Furuse
Mitsuhiro
M
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D015232:Dinoprostone / Q000235:genetics / Q000378:metabolism*; D004435:Eating / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D019787:Linoleic Acid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011451:Prostaglandin-Endoperoxide Synthases / Q000145:classification / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D013997:Time Factors
D004041:Dietary Fats; D012333:RNA, Messenger; D019787:Linoleic Acid; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone