[Advances in modulation of mammalian sperm function by fertilization promoting peptide].
Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss by modulation of the adenylyl cyclase (AC)/cAMP signal transduction pathway. This is a review aimed at analyzing the function of fertilization promoting peptide during this process. The possible molecular basis is also discussed.
Ma
Yongxin
Y
Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. szzhang@mcwcums.com
Zhang
Sizhong
S
D000177:Acrosome / Q000187:drug effects; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D008297:Male; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D015398:Signal Transduction / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; C059697:pyroglutamyl-glutamyl-proline amide; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D011761:Pyrrolidonecarboxylic Acid