title: Chordoma: natural history and results in 28 patients treated at a single institution.
abstract: BACKGROUND
  The natural history of chordoma is characterized by a high failure rate and a poor functional outcome. The purpose of this study was to review the long-term outcome of our institutional experience.
  
  
  METHODS
  The clinical features, type of treatment, pathologic assessment, and follow-up of 56 consecutive patients with chordoma were reviewed.
  
  
  RESULTS
  Fifty sacral and six mobile spine chordomas (median size, 13 cm; range, 2-30 cm) were treated at our center between January 1933 and December 2000. Twenty-eight patients affected by sacrococcygeal chordoma and operated on after 1977 form the basis of our study. Surgical margins were rated as wide in 11 cases, marginal in 13 cases, and intralesional in 4 cases. The median follow-up was 71 months (range, 15-200 months). Seventeen patients' disease recurred. Ten patients died as a result of disease. Nine patients remained continuously free of disease. The estimated 5- and 10-year overall survival was, respectively, 87.8% and 48.9%; disease-free survival was 60.6% and 24.2%. Radiotherapy was considered for marginal and intralesional resections.
  
  
  CONCLUSIONS
  High sacral amputation can achieve a good rate of wide-margin resections for sacrococcygeal chordomas. Adjuvant radiotherapy may offset the negative effect in the prognosis of marginal resections.
authors.affiliation: Department of Surgery, National Cancer Institute of Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Baratti
authors.forename: A
authors.initials: A
authors.lastname: Gronchi
authors.forename: E
authors.initials: E
authors.lastname: Pennacchioli
authors.forename: L
authors.initials: L
authors.lastname: Lozza
authors.forename: M
authors.initials: M
authors.lastname: Colecchia
authors.forename: M
authors.initials: M
authors.lastname: Fiore
authors.forename: M
authors.initials: M
authors.lastname: Santinami
mesh_terms: D000328:Adult; D000368:Aged; D002817:Chordoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012445:Sacrococcygeal Region / Q000473:pathology* / Q000601:surgery*; D013120:Spinal Cord Neoplasms / Q000473:pathology* / Q000601:surgery*; D013534:Survival; D016896:Treatment Outcome