title: Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
abstract: Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was established by X-ray diffraction analysis, while the structure assignment of trichodermamide A, and determination of the absolute stereochemistry, was accomplished by spectral and chemical methods. Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
authors.forename: Eliane
authors.initials: E
authors.lastname: Garo
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Starks
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: William
authors.initials: W
authors.lastname: Fenical
authors.forename: Emil
authors.initials: E
authors.lastname: Lobkovsky
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010219:Papua New Guinea; D013237:Stereoisomerism; D014242:Trichoderma / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004151:Dipeptides; C476747:trichodermamide A; C476748:trichodermamide B