title: Chromosomal aberrations of multiple myeloma in Chinese patients at diagnosis: a study by combined G-banding and multicolor spectral karyotyping.
abstract: Cytogenetic investigation of multiple myeloma (MM) has been difficult by conventional methods and most of the data have been derived from western population where incidence of MM is much higher as compared to that of Asians. The current study represents the first report of chromosomal aberrations of multiple myeloma in Chinese. We investigated 25 consecutive Chinese patients with MM for chromosomal aberrations at diagnosis using G-banding and multicolor spectral karyotyping (SKY). Of the 21 patients successfully analyzed by G-banding, 11 patients revealed cytogenetic abnormalities showing complex numerical and structural aberrations, which were further characterized with SKY. An abnormal karyotype significantly associated with blastic MM was observed. Consistent with the western literature, structural rearrangements involving chromosomes 1, 6, 8, 19, numerical abnormalities of gains in chromosomes 9, 3, and 5, and losses in chromosomes 13 and 14 were observed. However, there were notably higher incidences of -22/22q- (4/11) and structural aberrations of chromosome X but a lower incidence of -X. The biological implications of these findings, if confirmed, deserve further evaluation.
authors.affiliation: Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong SAR. margaretng@cuhk.edu.hk
authors.forename: Margaret Heung-Ling
authors.initials: MH
authors.lastname: Ng
authors.forename: Nathalie
authors.initials: N
authors.lastname: Wong
authors.forename: Tai Tap
authors.initials: TT
authors.lastname: Lau
authors.forename: Kam Sze
authors.initials: KS
authors.lastname: Tsang
authors.forename: Suk Hang
authors.initials: SH
authors.lastname: Cheng
authors.forename: Natalie Pui-Ha
authors.initials: NP
authors.lastname: Chan
authors.forename: Sheung Hang
authors.initials: SH
authors.lastname: Tang
authors.forename: Kenny Ieng-Kit
authors.initials: KI
authors.lastname: Lei
authors.forename: Yonna
authors.initials: Y
authors.lastname: Leung
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D002869:Chromosome Aberrations; D002871:Chromosome Banding / Q000379:methods*; D020223:Chromosome Painting / Q000379:methods; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology