[Molecular cancer biology--from research to clinical practice].
Recent progress in our understanding of the mechanism of transformation has contributed to the development of novel molecular approaches for the detection and classification of cancer. The review focuses on the molecular background of cancer, the role of oncogenic kinases, genetic instability and embryonal signalling pathways. Moreover, examples of novel diagnostic and therapeutic possibilities are described.
Nielsen
Finn Cilius
FC
Klinisk Biokemisk Afdeling, H:S Rigshospitalet, DK-2100 København Ø.
D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020732:Cytogenetic Analysis; D004260:DNA Repair; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D025202:Molecular Diagnostic Techniques; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009857:Oncogenes / Q000502:physiology; D011519:Proto-Oncogenes / Q000502:physiology; D012106:Research; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology