[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone].
A new drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats with global recurrent brain ischemia and in a model ischemic state under high radial gravitational overload. In the former case, the new drug increases the blood circulation in rats with the global ischemic damage to a greater extent than in the intact control group. Pretreatment with the pyroglutamic acid--pyrrolidone composition produced a 2-2.5-fold increase in the survival of rats in the ischemic state caused by the radial gravitational overload. The data obtained show evidence of a substantial neuroprotector action of the new drug composition.
Lun'shina
E V
EV
Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya Str. 8, Moscow, 125315, Russia.
Gan'shina
T S
TS
Makarova
L M
LM
Pogorelyĭ
V E
VE
Mirzoian
R S
RS
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004338:Drug Combinations; D018471:Hypergravity / Q000009:adverse effects; D002546:Ischemic Attack, Transient / Q000503:physiopathology / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011760:Pyrrolidinones / Q000008:administration & dosage*; D011761:Pyrrolidonecarboxylic Acid / Q000008:administration & dosage*; D051381:Rats
D004338:Drug Combinations; D018696:Neuroprotective Agents; D011760:Pyrrolidinones; D011761:Pyrrolidonecarboxylic Acid