title: Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
abstract: The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.
authors.affiliation: Shire BioChem Inc., 275 Armand-Frappier Boulevard, Laval, Quebec H7V 4A7, Canada. lchan@ca.shire.com
authors.forename: Laval
authors.initials: L
authors.lastname: Chan
authors.forename: T Jagadeeswar
authors.initials: TJ
authors.lastname: Reddy
authors.forename: Mélanie
authors.initials: M
authors.lastname: Proulx
authors.forename: Sanjoy K
authors.initials: SK
authors.lastname: Das
authors.forename: Oswy
authors.initials: O
authors.lastname: Pereira
authors.forename: Wuyi
authors.initials: W
authors.lastname: Wang
authors.forename: Arshad
authors.initials: A
authors.lastname: Siddiqui
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Yannopoulos
authors.forename: Carl
authors.initials: C
authors.lastname: Poisson
authors.forename: Nathalie
authors.initials: N
authors.lastname: Turcotte
authors.forename: Alexandre
authors.initials: A
authors.lastname: Drouin
authors.forename: M Hicham
authors.initials: MH
authors.lastname: Alaoui-Ismaili
authors.forename: Richard
authors.initials: R
authors.lastname: Bethell
authors.forename: Martine
authors.initials: M
authors.lastname: Hamel
authors.forename: Lucille
authors.initials: L
authors.lastname: L'Heureux
authors.forename: Darius
authors.initials: D
authors.lastname: Bilimoria
authors.forename: Nghe
authors.initials: N
authors.lastname: Nguyen-Ba
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D016174:Hepacivirus / Q000201:enzymology*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D017361:Viral Nonstructural Proteins; D010649:Phenylalanine; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase