title: Anti-leukemia activity of 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-one derivatives.
abstract: The synthesis of new 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl+ leukemia cells.
authors.affiliation: EA 2962-Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Guillon
authors.forename: Maria
authors.initials: M
authors.lastname: Mamani-Matsuda
authors.forename: Stephane
authors.initials: S
authors.lastname: Massip
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Leger
authors.forename: Denis
authors.initials: D
authors.lastname: Thiolat
authors.forename: Djavad
authors.initials: D
authors.lastname: Mossalayi
authors.forename: Christian
authors.initials: C
authors.lastname: Jarry
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000494:pharmacology; D000077543:Deferiprone; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007502:Iron Chelating Agents / Q000737:chemistry; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007502:Iron Chelating Agents; D010080:Oxazoles; D011728:Pyridones; D011744:Pyrimidinones; D000077543:Deferiprone