title: Modeling homeorhetic and homeostatic controls of pig growth.
abstract: A dynamic mechanistic model of homeorhetic and homeostatic controls of pig growth was developed. The homeorhetic principles were based on changes in time of fractional rates of anabolism and catabolism of tissues. A minimum number of homeostatic principles integrated current data on plasma kinetics and the partitioning of nutrients between anabolism and catabolism of body tissues, and endogenous losses with integument and into the gut. The major features of the model are two levels of organization (tissue and plasma) and three body tissues (carcass proteins, visceral proteins, and body lipids). The protein tissues and plasma amino acids were subdivided into lysine, methionine and cystine, threonine, tryptophan, other essential AA, and nonessential AA compartments. Plasma glucose and fatty acids were also considered. Adenosine triphosphate and adenosine diphosphate were used to represent energy transformations, although these energy transformations were not included in the homeostatic control of pig growth. The mass variations within each of the 23 basic compartments were described with a specific deterministic, dynamic differential equation. The simulated metabolic rates of the protein and lipid tissues were similar to published data. The principal outputs from the model (protein and lipid gain, body weight, chemical body constituents, plasma parameters) showed that the proposed homeorhetic and homeostatic controls provide a mechanistic approach to modeling growth.
authors.affiliation: UMR INRA-INAPG Physiologie de la Nutrition et Alimentation 75231, Paris, France.
authors.forename: P A
authors.initials: PA
authors.lastname: Lovatto
authors.forename: D
authors.initials: D
authors.lastname: Sauvant
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001823:Body Composition; D004734:Energy Metabolism / Q000502:physiology*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D013552:Swine / Q000254:growth & development*; D015430:Weight Gain / Q000502:physiology
chemical_list: D000596:Amino Acids; D005227:Fatty Acids; D011506:Proteins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate