title: Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions.
abstract: A short personal perspective on the development of an approach to the solution-phase synthesis of combinatorial libraries for modulating cellular signaling by inhibiting, promoting, or mimicking protein-protein or protein-DNA interactions is provided.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550North Torrey Pines Road, La Jolla, CA 92037, USA. boger@scripps.edu
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D008024:Ligands; D061965:Matrix Metalloproteinase Inhibitors; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000819:agonists; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D015815:Cell Adhesion Molecules; D008024:Ligands; D061965:Matrix Metalloproteinase Inhibitors; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc; D017467:Receptors, Erythropoietin; D014157:Transcription Factors; D004247:DNA