title: Enzymatic synthesis of chiral intermediates for pharmaceuticals.
abstract: There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.
authors.affiliation: Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA. Patelr@bms.com
authors.forename: Ramesh
authors.initials: R
authors.lastname: Patel
authors.forename: Ronald
authors.initials: R
authors.lastname: Hanson
authors.forename: Animesh
authors.initials: A
authors.lastname: Goswami
authors.forename: Venkata
authors.initials: V
authors.lastname: Nanduri
authors.forename: Amit
authors.initials: A
authors.lastname: Banerjee
authors.forename: Mary-Jo
authors.initials: MJ
authors.lastname: Donovan
authors.forename: Steven
authors.initials: S
authors.lastname: Goldberg
authors.forename: Robert
authors.initials: R
authors.lastname: Johnston
authors.forename: David
authors.initials: D
authors.lastname: Brzozowski
authors.forename: Thomas
authors.initials: T
authors.lastname: Tully
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Howell
authors.forename: Dana
authors.initials: D
authors.lastname: Cazzulino
authors.forename: Rapheal
authors.initials: R
authors.lastname: Ko
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000378:metabolism*; D000959:Antihypertensive Agents / Q000378:metabolism*; D001711:Biotransformation; D002626:Chemistry, Pharmaceutical; D004798:Enzymes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000819:agonists* / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism*; D044094:Receptors, Melatonin; D013237:Stereoisomerism
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D000959:Antihypertensive Agents; D004798:Enzymes; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin