Neuroendocrinological aspects of primary empty sella.
Neuroendocrinological aspects of 42 patients (33 women, 9 men) with primary empty sella confirmed by CT, cysternography and/or MR imaging were analyzed. The prominent symptoms were headache, visual disturbances and hypertension, occurring primarily in obese women (84.5%). Patients underwent dynamic endocrine testing consisting of insulin-induced hypoglycemia and anterior pituitary stimulation tests GnRH and TRH. Variable degree of pituitary dysfunction was observed in 28 (66.6%) patients. In this study 20 (47.6%) patients were presented with latent hypopituitarism, while manifest hypopituitarism, requiring replacement therapy, occurred in 8 (19%) patients. Mild hyperprolactinaemia was found in 3 patients. Even 14 (33.3%) patients had no evidence of endocrine dysfunction. Often mentioned diabetes insipidus and rhinoliquorrhea were not reported in this study.
Becejac
B
B
Department of Neuroendocrinology and Pituitary Diseases, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
Vizner
B
B
Berković
M
M
Gnjidić
Z
Z
Vrkljan
M
M
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007018:Hypopituitarism / Q000150:complications / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012658:Sella Turcica / Q000002:abnormalities*; D013577:Syndrome; D014786:Vision Disorders / Q000209:etiology