title: New acetylenic acids from the marine sponge Stelletta species.
abstract: Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea, Korea.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Zhao
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Chung Ja
authors.initials: CJ
authors.lastname: Sim
authors.forename: Dong Seok
authors.initials: DS
authors.lastname: Lee
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; C031203:2-hexadecynoic acid