Platelet physiology: in cold blood.
One of the impediments precluding long-term storage of platelets for blood transfusion is that refrigerated platelets are rapidly cleared from the circulation upon transfusion. New evidence suggests that this clearance is mediated in the liver by the Mac-1 integrin on Kupffer cells recognizing clustered GPIb receptor on platelets, leading to platelet phagocytosis.
Andrews
Robert K
RK
Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia.
Berndt
Michael C
MC
D001792:Blood Platelets / Q000502:physiology*; D001803:Blood Transfusion; D006801:Humans; D007728:Kupffer Cells / Q000502:physiology; D016177:Macrophage-1 Antigen / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology; D010973:Platelet Adhesiveness / Q000502:physiology*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins; D012034:Refrigeration; D013696:Temperature
D016177:Macrophage-1 Antigen; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; C032193:glycoprotein receptor GPIb-IX