Lupus-associated toxic epidermal necrolysis: a novel manifestation of lupus?
BACKGROUND
Toxic epidermal necrolysis is an acute mucocutaneous reaction characterized by extensive cutaneous and mucosal sloughing and systemic involvement. It is generally associated with drug ingestion.


OBJECTIVE
We describe 2 patients who developed typical clinical and histopathologic features of toxic epidermal necrolysis with unusual subacute progression, absence of systemic involvement or high-risk drug ingestion, and features of lupus erythematosus.


CONCLUSIONS
We propose that this constellation of features represents a new entity not previously described. This entity may represent a more severe variant of Rowell's syndrome or, alternatively, a novel manifestation of lupus erythematosus
Mandelcorn
Rochelle
R
Division of Dermatology, Department of Medicine, University of Toronto.
Shear
Neil H
NH
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology