Extensive retinal neovascularization as a late finding in human immunodeficiency virus-infected patients with immune recovery uveitis.
Sixteen human immunodeficiency virus (HIV)-infected patients with inactive cytomegalovirus (CMV) retinitis who had discontinued systemic anti-CMV therapy while receiving highly active antiretroviral therapy (HAART) were prospectively observed. Fifteen patients developed immune recovery uveitis (IRU); 3 of the patients developed extensive retinal neovascularization, 1 of whom required vitrectomy for recurrent vitreous hemorrhages. These late complications indicate a need for continued ophthalmologic follow-up of HIV-infected patients who have a history of CMV retinitis, even for individuals who have not required anti-CMV therapy for >4 years.
Wright
Mary E
ME
National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA.
Suzman
Daniel L
DL
Csaky
Karl G
KG
Masur
Henry
H
Polis
Michael A
MA
Robinson
Michael R
MR
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000209:etiology* / Q000276:immunology; D014605:Uveitis / Q000150:complications* / Q000276:immunology