Repeated surgical excision for an unusual variant of nephroblastoma: case report and review of the literature.
Bilateral fetal rhabdomyomatous nephroblastoma is a rare variant of Wilms' Tumor. The authors report the evolution over 48 months of a 10-month-old baby with bilateral nephroblastoma for which a left nephrectomy was initially performed. A right kidney tumor was enucleated preserving the kidney. The transformation of the primary tumor into a completely differentiated cystic nephroblastoma or nephromalike tumor and the appearance of a metachronous lesion was seen. This report emphasizes the role of nephron-sparing surgery in bilateral Wilms' Tumor when a benign transformation occurs under chemotherapy.
Joseph
J M
JM
Department of Pediatric Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Suter
O C
OC
Nenadov-Beck
M
M
Gudinchet
F
F
Frey
P
P
Meagher-Villemure
K
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology; D009396:Wilms Tumor / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
D003609:Dactinomycin; D014750:Vincristine