[Preliminary investigation on the relation between clinical progress and anti-small monomolecular peptides antibody in individual infected with HIV].
OBJECTIVE
To study the quantity of anti-R7V in individuals infected with HIV and AIDS patients and its relation with the progression of disease.


METHODS
ELISA and precipitation and other methods were used to investigate the quantity of anti-R7V in asymptomatic long-term survivors and AIDS patients.


RESULTS
Positive rate and quantity of anti-R7V were higher in the HIV active ones and AIDS. It showed that the quantity and positive rate of anti-R7V were rather high in dissolving test.


CONCLUSIONS
It is strong suggestion for anti-R7V to obstruct the replication of virus by interfering the connection between HIV with CCR5 or CXCR4 and so it impossible HIV entering to CD4+ T cells.
Xu
Xiaoyuan
X
Department of Infectious Diseases, the First Hospital, Beijing University, Beijing 100034,China.
Xing
Huichun
H
Gong
Weibo
W
Chen
Hongmei
H
Si
Chongwen
C
Wang
Yan
Y
Chermann
J C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019713:Receptors, CCR5 / Q000502:physiology; D019718:Receptors, CXCR4 / Q000502:physiology
D015483:HIV Antibodies; D019713:Receptors, CCR5; D019718:Receptors, CXCR4