Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells.
A set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was tested with the aim to quantify the effect observed on drug efflux. Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents.
Alibert
Sandrine
S
GERCTOP-UMR CNRS 6009, faculté de pharmacie, Université de la Méditerranée, 27, bd Jean Moulin, 13385 cedex 05, Marseille, France.
Santelli-Rouvier
Christiane
C
Castaing
Madeleine
M
Berthelot
Michel
M
Spengler
Gabriella
G
Molnar
Jozsef
J
Barbe
Jacques
J
D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D019295:Computational Biology; D018432:Drug Resistance, Multiple / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005456:Fluorescent Dyes; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D051379:Mice; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011405:Propafenone / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D020112:Rhodamine 123
D000873:Anthracenes; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D020112:Rhodamine 123; D011405:Propafenone