Biokinetics and radiation dosimetry for patients undergoing a glycerol tri[1-14C]oleate fat malabsorption breath test.
The glycerol tri[1-14C]olein test for fat malabsorption was carried out in two male volunteers and measurements of the loss of 14C in expired air, urine and faeces and the retention of 14C in biopsy samples of abdominal fat were made using accelerator mass spectrometry. Exhalation accounted for 73% and 55% of the administered activity and could be described by three-component exponential functions with halftimes of about 1h, 2 days and 150 days, respectively. Urinary excretion accounted for 24% of the administered activity, almost all during the first 24h after administration; about 2% was excreted in the faeces in 48h. The halftime of retention of 14C in fat ranged from 137 to 620 days. Absorbed dose calculations indicate that for a normal adult the largest dose, 1.5-7.0mGy/MBq is received by the adipose tissue, and that the effective dose is 0.3-0.5mSv/MBq. It is concluded that no restrictions need to be placed on radiation safety grounds on the administration of 0.05-0.1MBq 14C-triolein for the triolein breath test.
Gunnarsson
Mikael
M
Department of Radiation Physics, Lund University, Malmö University Hospital, SE-205 02, Malmö, Sweden. mikael.gunnarsson@rfa.mas.lu.se
Stenström
Kristina
K
Leide-Svegborn
Sigrid
S
Faarinen
Mikko
M
Magnusson
Carl-Erik
CE
Aberg
Magnus
M
Skog
Göran
G
Hellborg
Ragnar
R
Mattsson
Sören
S
D000273:Adipose Tissue / Q000737:chemistry / Q000473:pathology; D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis / Q000737:chemistry*; D002250:Carbon Radioisotopes; D004041:Dietary Fats / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D006801:Humans; D008286:Malabsorption Syndromes / Q000000981:diagnostic imaging* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D014304:Triolein / Q000737:chemistry* / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D004041:Dietary Fats; D014304:Triolein; D002245:Carbon Dioxide