[Dizocilpine inhibits suppression of c-fos gene by delta-sleep peptide in the rat hypothalamic paraventricular nucleus].
The effects of intracerebroventricular administration of the non-competitive NMDA-receptor blocker Dizocilpine (MK-801) on delta sleep-inducing peptide (DSIP) suppression of c-fos induction, were studied. The data obtained indicate that preliminary i.c.v. MK-801 injection inhibits immediate early gene c-fos suppression by DSIP in the parvocellular paraventricular hypothalamus.
Umriukhin
P E
PE
P. K. Anokhin Research Institute of Normal Physiology, Russian Acad. Med. Sci., Moscow 103009, B. Nikitskaya, 6, Russia.
Anokhin
K V
KV
Raevskiĭ
K S
KS
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D017781:Genes, Immediate-Early / Q000235:genetics; D016762:Genes, fos / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013315:Stress, Psychological / Q000235:genetics
D016760:Proto-Oncogene Proteins c-fos; D016194:Receptors, N-Methyl-D-Aspartate; D003701:Delta Sleep-Inducing Peptide; D016291:Dizocilpine Maleate