title: Folium mori increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats.
abstract: The possibility has been raised that Folium mori is clinically effective for the treatment and prevention of diabetes. In the present study, the effects of Folium mori on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus of rats with streptozotocin (STZ)-induced diabetes were investigated by 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and NPY immunohistochemistry. In rats with STZ-induced diabetes, cell proliferation and NPY expression in the dentate gyrus were suppressed, and treatment with Folium mori was shown to increase new cell formation and NPY expression in the dentate gyrus in both normal rats and those with STZ-induced diabetes. In light of previous studies, this result appears to indicate that increased expression of NPY in the dentate gyrus induced by treatment with Folium mori is associated with the observed effect of Folium mori extract on cell proliferation. Based on the present results, it is suggested that Folium mori treatment may aid in the recovery from the central nervous system complications of diabetes mellitus.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Chang-Young
authors.initials: CY
authors.lastname: Jung
authors.forename: Choong-Yeol
authors.initials: CY
authors.lastname: Lee
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D018891:Dentate Gyrus / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D008297:Male; D031625:Morus; D009478:Neuropeptide Y / Q000096:biosynthesis* / Q000235:genetics; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013150:Spirostans / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D009478:Neuropeptide Y; D010936:Plant Extracts; D012503:Saponins; D013150:Spirostans; C090266:foliumin