title: Management of respiratory distress syndrome: an update.
abstract: Respiratory distress syndrome is the most common respiratory disorder in preterm infants. Over the last decade, because of improvements in neonatal care and increased use of antenatal steroids and surfactant replacement therapy, mortality from respiratory distress syndrome has dropped substantially. However, respiratory morbidity, primarily bronchopulmonary dysplasia, remains unacceptably high. The management of respiratory distress syndrome in preterm infants is based on various modalities of respiratory support and the application of fundamental principles of neonatal care. To obtain best results, a multidisciplinary approach is crucial. This review discusses surfactant replacement therapy and some of the current strategies in ventilatory management of preterm infants with respiratory distress syndrome.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Case Western Reserve University, and Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA. rjr8@po.cwru.edu.
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Rodriguez
mesh_terms: D019468:Disease Management; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal / Q000379:methods / Q000639:trends*; D009569:Nitric Oxide / Q000627:therapeutic use; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy / Q000628:therapy*; D012138:Respiratory Therapy / Q000379:methods / Q000639:trends*; D014481:United States
chemical_list: D011663:Pulmonary Surfactants; D009569:Nitric Oxide