title: Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes.
abstract: The derivatization of racemic 5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, developed as an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate was performed in chloroform. The reaction led to two pairs of diastereomers, which were separated by RP-HPLC. A kinetic study of the derivatization reaction was achieved in order to establish conditions suitable for experimental drug monitoring.
authors.affiliation: EA 2962-Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Matoga
authors.forename: Isabelle
authors.initials: I
authors.lastname: Forfar
authors.forename: Corinne
authors.initials: C
authors.lastname: Chaimbault
authors.forename: Jean
authors.initials: J
authors.lastname: Guillon
authors.forename: Fabienne
authors.initials: F
authors.lastname: Péhourcq
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bosc
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Rettori
authors.forename: Christian
authors.initials: C
authors.lastname: Jarry
mesh_terms: D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016903:Drug Monitoring / Q000379:methods*; D017953:Isocyanates / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D017953:Isocyanates; D008024:Ligands; D010080:Oxazoles; C060557:alpha-methylbenzyl isocyanate