A novel experimental method to estimate stress-strain behavior of intact coronary arteries using intravascular ultrasound (IVUS).
Most arterial mechanics studies have focused on excised non-coronary vessels, with few studies validating the application of ex-vivo results to in-vivo conditions. A method was developed for testing the mechanical properties of intact left anterior descending coronary arteries under a variety of conditions. Vascular deformation and pressure were simultaneously measured with intravascular ultrasound and a pressure transducer guidewire, respectively. Results suggest the importance of understanding in-vivo factors such as myocardial support, vascular tone and local pressure fluctuations when applying ex-vivo coronary characterization data. With further development, this method can more accurately characterize the true in-vivo constitutive behavior in normal and atherosclerotic coronaries.
Tajaddini
Azita
A
Department of Biomedical Engineering/ND20 Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. tajadda@bme.ri.ccf.org
Kilpatrick
Deborah L
DL
Vince
D Geoffrey
DG
D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004548:Elasticity; D005240:Feasibility Studies; D006801:Humans; D009038:Motion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013552:Swine; D018084:Ultrasonography, Interventional / Q000379:methods*