The relationship between leptin and lipids in atherosclerosis.
BACKGROUND
This study aimed to examine the extent to which leptin, alone or in combination with other risk factors, may be an independent marker for myocardial infarction in a region with a high incidence of cardiovascular disease.


RESULTS
Leptin levels were measured by the ELISA method, while plasma lipids and lipoproteins were measured by conventional methods. Leptin levels were significantly higher in the patient than in the control group. Serum total cholesterol, low-density lipoprotein, lipoprotein (a) and apolipoprotein B showed a significant correlation with leptin, while high-density lipoprotein showed an inverse relation.


CONCLUSIONS
Our results suggest that leptin may be one factor operating in the metabolic alteration taking place during myocardial infarction, and is a possible risk factor.
Tamer
L
L
Department of Biochemistry, Mersin University, Turkey. lutamer@yahoo.com
Ercan
B
B
Unlü
A
A
Sucu
N
N
Pekdemir
H
H
Eskandari
G
G
Atik
U
U
D001053:Apolipoproteins / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood*; D012307:Risk Factors
D001053:Apolipoproteins; D020738:Leptin; D008055:Lipids; D017270:Lipoprotein(a)