title: Preliminary results using ultrasound transmission for image-guided thermal therapy.
abstract: The feasibility of using an acoustic camera as a real-time imaging device for thermal surgery was investigated. The study compares camera images of tissue samples taken before, during and after a volume of tissue was thermally coagulated using focused ultrasound (US). This apparatus has analogous acoustic counterparts to an optical charge couple device (CCD) camera. The setup was operated in transmission mode, with a tissue sample placed between the camera and a 10-MHz illuminating transducer. A high-intensity continuous-wave US signal from a therapeutic transducer was focused inside the sample tissue. A reversible, time-dependent variation in image intensity was observed in the region of the therapeutic sonications in all tissues tested: bovine fat and porcine and rabbit livers. Correlations between image intensities and temperatures were shown; rabbit liver resulted in a correlation coefficient (R(2)) of 0.6694 and bovine fat resulted in an R(2) of 0.9455. When temperatures high enough to coagulate tissue were reached, permanent changes in the images were observed. Lesion locations and dimensions from the images were found to be comparable to the sectioned tissue samples. An R(2) of 0.919 resulted when lesion size detected from the camera was compared to the actual lesion size. Preliminary results may indicate that the camera has an application for monitoring thermal surgery.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. rlking@bwh.harvard.edu
authors.forename: R L
authors.initials: RL
authors.lastname: King
authors.forename: G T
authors.initials: GT
authors.lastname: Clement
authors.forename: S
authors.initials: S
authors.lastname: Maruvada
authors.forename: K
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D002417:Cattle; D005240:Feasibility Studies; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D033401:Microscopy, Acoustic / Q000379:methods*; D011817:Rabbits; D013552:Swine; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*