Pd-catalyzed carbonylative cross-coupling reactions by triorganoindiums: highly efficient transfer of organic groups attached to indium under atmospheric pressure.
[reaction: see text] A highly atom-efficient synthetic method of unsymmetrical ketones was developed by using trialkyl- and triarylindiums, which could be employed as effective cross-coupling partners in Pd-catalyzed carbonylative cross-coupling reactions with a variety of organic electrophiles. The present method produced unsymmetrical ketones and 1,4-diacylbenzenes in good yields with highly efficient transfer of almost all the organic groups attached to the indium under atmospheric pressure of CO gas in THF at 66 degrees C.
Lee
Phil Ho
PH
Department of Chemistry, Kangwon National University, Chunchon 200-701, Republic of Korea. phlee@kangwon.ac.kr
Lee
Sung Wook
SW
Lee
Kooyeon
K